PMC:2222968 / 7387-8083 JSONTXT

{"project":"pmc-enju-pas","denotations":[{"id":"T3216","span":{"begin":0,"end":3},"obj":"NN"},{"id":"T3217","span":{"begin":4,"end":9},"obj":"NN"},{"id":"T3218","span":{"begin":580,"end":583},"obj":"VB"},{"id":"T3219","span":{"begin":584,"end":589},"obj":"VB"},{"id":"T3220","span":{"begin":590,"end":592},"obj":"TO"},{"id":"T3221","span":{"begin":593,"end":600},"obj":"VB"},{"id":"T3222","span":{"begin":601,"end":605},"obj":"NN"},{"id":"T3223","span":{"begin":606,"end":610},"obj":"IN"},{"id":"T3224","span":{"begin":611,"end":621},"obj":"NN"},{"id":"T3225","span":{"begin":621,"end":622},"obj":"-COMMA-"},{"id":"T3226","span":{"begin":623,"end":628},"obj":"WDT"},{"id":"T3227","span":{"begin":629,"end":632},"obj":"MD"},{"id":"T3228","span":{"begin":633,"end":641},"obj":"VB"},{"id":"T3229","span":{"begin":642,"end":646},"obj":"IN"},{"id":"T3230","span":{"begin":647,"end":652},"obj":"NN"},{"id":"T3231","span":{"begin":653,"end":662},"obj":"NN"},{"id":"T3232","span":{"begin":663,"end":666},"obj":"CC"},{"id":"T3233","span":{"begin":667,"end":671},"obj":"RB"},{"id":"T3234","span":{"begin":672,"end":679},"obj":"VB"},{"id":"T3235","span":{"begin":680,"end":685},"obj":"NN"},{"id":"T3236","span":{"begin":686,"end":695},"obj":"NN"},{"id":"T23464","span":{"begin":0,"end":3},"obj":"NN"},{"id":"T23465","span":{"begin":4,"end":9},"obj":"NN"},{"id":"T23466","span":{"begin":10,"end":13},"obj":"MD"},{"id":"T23467","span":{"begin":13,"end":16},"obj":"RB"},{"id":"T23468","span":{"begin":17,"end":23},"obj":"VB"},{"id":"T23469","span":{"begin":24,"end":29},"obj":"NN"},{"id":"T23470","span":{"begin":30,"end":40},"obj":"NN"},{"id":"T23471","span":{"begin":41,"end":42},"obj":"-LRB-"},{"id":"T23472","span":{"begin":42,"end":43},"obj":"NN"},{"id":"T23473","span":{"begin":43,"end":44},"obj":"-RRB-"},{"id":"T23474","span":{"begin":45,"end":50},"obj":"JJ"},{"id":"T23475","span":{"begin":51,"end":52},"obj":"NN"},{"id":"T23476","span":{"begin":53,"end":58},"obj":"NN"},{"id":"T23477","span":{"begin":59,"end":63},"obj":"VB"},{"id":"T23478","span":{"begin":64,"end":73},"obj":"VB"},{"id":"T23479","span":{"begin":74,"end":78},"obj":"IN"},{"id":"T23480","span":{"begin":79,"end":90},"obj":"JJ"},{"id":"T23481","span":{"begin":91,"end":104},"obj":"NN"},{"id":"T23482","span":{"begin":105,"end":109},"obj":"IN"},{"id":"T23483","span":{"begin":110,"end":112},"obj":"CC"},{"id":"T23484","span":{"begin":113,"end":120},"obj":"IN"},{"id":"T23485","span":{"begin":121,"end":126},"obj":"NN"},{"id":"T23486","span":{"begin":127,"end":129},"obj":"IN"},{"id":"T23487","span":{"begin":130,"end":139},"obj":"VB"},{"id":"T23488","span":{"begin":140,"end":142},"obj":"IN"},{"id":"T23489","span":{"begin":143,"end":146},"obj":"DT"},{"id":"T23490","span":{"begin":147,"end":153},"obj":"NN"},{"id":"T23491","span":{"begin":154,"end":156},"obj":"IN"},{"id":"T23492","span":{"begin":157,"end":158},"obj":"-LRB-"},{"id":"T23493","span":{"begin":158,"end":159},"obj":"NN"},{"id":"T23494","span":{"begin":159,"end":160},"obj":"-RRB-"},{"id":"T23495","span":{"begin":162,"end":167},"obj":"NN"},{"id":"T23496","span":{"begin":168,"end":172},"obj":"VB"},{"id":"T23497","span":{"begin":173,"end":182},"obj":"VB"},{"id":"T23498","span":{"begin":183,"end":188},"obj":"IN"},{"id":"T23499","span":{"begin":189,"end":190},"obj":"CD"},{"id":"T23500","span":{"begin":191,"end":195},"obj":"NN"},{"id":"T23501","span":{"begin":196,"end":199},"obj":"CC"},{"id":"T23502","span":{"begin":200,"end":205},"obj":"NN"},{"id":"T23503","span":{"begin":206,"end":210},"obj":"NN"},{"id":"T23504","span":{"begin":211,"end":214},"obj":"VB"},{"id":"T23505","span":{"begin":215,"end":225},"obj":"VB"},{"id":"T23506","span":{"begin":226,"end":228},"obj":"IN"},{"id":"T23507","span":{"begin":229,"end":238},"obj":"JJ"},{"id":"T23508","span":{"begin":239,"end":242},"obj":"NN"},{"id":"T23509","span":{"begin":244,"end":248},"obj":"NN"},{"id":"T23510","span":{"begin":249,"end":253},"obj":"VB"},{"id":"T23511","span":{"begin":254,"end":257},"obj":"DT"},{"id":"T23512","span":{"begin":258,"end":262},"obj":"JJ"},{"id":"T23513","span":{"begin":263,"end":264},"obj":"JJ"},{"id":"T23514","span":{"begin":265,"end":267},"obj":"NN"},{"id":"T23515","span":{"begin":268,"end":270},"obj":"IN"},{"id":"T23516","span":{"begin":271,"end":272},"obj":"CD"},{"id":"T23517","span":{"begin":273,"end":284},"obj":"JJ"},{"id":"T23518","span":{"begin":285,"end":296},"obj":"NN"},{"id":"T23519","span":{"begin":298,"end":299},"obj":"-LRB-"},{"id":"T23520","span":{"begin":299,"end":300},"obj":"NN"},{"id":"T23521","span":{"begin":300,"end":301},"obj":"-RRB-"},{"id":"T23522","span":{"begin":302,"end":304},"obj":"FW"},{"id":"T23523","span":{"begin":305,"end":310},"obj":"FW"},{"id":"T23524","span":{"begin":311,"end":325},"obj":"VB"},{"id":"T23525","span":{"begin":326,"end":329},"obj":"NN"},{"id":"T23526","span":{"begin":329,"end":330},"obj":"-COMMA-"},{"id":"T23527","span":{"begin":331,"end":334},"obj":"NN"},{"id":"T23528","span":{"begin":334,"end":335},"obj":"-COMMA-"},{"id":"T23529","span":{"begin":336,"end":338},"obj":"CC"},{"id":"T23530","span":{"begin":339,"end":344},"obj":"NN"},{"id":"T23531","span":{"begin":345,"end":350},"obj":"NN"},{"id":"T23532","span":{"begin":351,"end":355},"obj":"VB"},{"id":"T23533","span":{"begin":356,"end":365},"obj":"VB"},{"id":"T23534","span":{"begin":366,"end":370},"obj":"IN"},{"id":"T23535","span":{"begin":371,"end":384},"obj":"JJ"},{"id":"T23536","span":{"begin":384,"end":385},"obj":"-COMMA-"},{"id":"T23537","span":{"begin":386,"end":391},"obj":"NN"},{"id":"T23538","span":{"begin":391,"end":392},"obj":"-COMMA-"},{"id":"T23539","span":{"begin":393,"end":395},"obj":"CC"},{"id":"T23540","span":{"begin":396,"end":405},"obj":"NN"},{"id":"T23541","span":{"begin":406,"end":408},"obj":"IN"},{"id":"T23542","span":{"begin":409,"end":418},"obj":"VB"},{"id":"T23543","span":{"begin":420,"end":423},"obj":"DT"},{"id":"T23544","span":{"begin":424,"end":433},"obj":"NN"},{"id":"T23545","span":{"begin":434,"end":436},"obj":"IN"},{"id":"T23546","span":{"begin":437,"end":442},"obj":"DT"},{"id":"T23547","span":{"begin":443,"end":448},"obj":"NN"},{"id":"T23548","span":{"begin":449,"end":452},"obj":"VB"},{"id":"T23549","span":{"begin":453,"end":462},"obj":"VB"},{"id":"T23550","span":{"begin":463,"end":465},"obj":"IN"},{"id":"T23551","span":{"begin":466,"end":470},"obj":"NN"},{"id":"T23552","span":{"begin":471,"end":474},"obj":"CC"},{"id":"T23553","span":{"begin":475,"end":488},"obj":"NN"},{"id":"T23554","span":{"begin":489,"end":497},"obj":"NN"},{"id":"T23555","span":{"begin":498,"end":499},"obj":"-LRB-"},{"id":"T23556","span":{"begin":499,"end":505},"obj":"NN"},{"id":"T23557","span":{"begin":506,"end":508},"obj":"NN"},{"id":"T23558","span":{"begin":508,"end":509},"obj":"-RRB-"},{"id":"T23559","span":{"begin":511,"end":515},"obj":"NN"},{"id":"T23560","span":{"begin":516,"end":520},"obj":"VB"},{"id":"T23561","span":{"begin":521,"end":524},"obj":"DT"},{"id":"T23562","span":{"begin":525,"end":529},"obj":"JJ"},{"id":"T23563","span":{"begin":530,"end":531},"obj":"JJ"},{"id":"T23564","span":{"begin":532,"end":534},"obj":"NN"},{"id":"T23565","span":{"begin":535,"end":537},"obj":"IN"},{"id":"T23566","span":{"begin":538,"end":542},"obj":"CD"},{"id":"T23567","span":{"begin":543,"end":554},"obj":"JJ"},{"id":"T23568","span":{"begin":555,"end":566},"obj":"NN"}],"relations":[{"id":"R2576","pred":"arg1Of","subj":"T3217","obj":"T3216"},{"id":"R2577","pred":"arg1Of","subj":"T3217","obj":"T3218"},{"id":"R2578","pred":"arg2Of","subj":"T3217","obj":"T3219"},{"id":"R2579","pred":"arg1Of","subj":"T3217","obj":"T3221"},{"id":"R2580","pred":"arg2Of","subj":"T3219","obj":"T3218"},{"id":"R2581","pred":"arg3Of","subj":"T3221","obj":"T3219"},{"id":"R2582","pred":"arg1Of","subj":"T3221","obj":"T3220"},{"id":"R2583","pred":"arg1Of","subj":"T3221","obj":"T3223"},{"id":"R2584","pred":"arg2Of","subj":"T3222","obj":"T3221"},{"id":"R2585","pred":"arg2Of","subj":"T3224","obj":"T3223"},{"id":"R2586","pred":"arg1Of","subj":"T3224","obj":"T3225"},{"id":"R2587","pred":"arg1Of","subj":"T3224","obj":"T3226"},{"id":"R2588","pred":"arg1Of","subj":"T3224","obj":"T3227"},{"id":"R2589","pred":"arg1Of","subj":"T3224","obj":"T3228"},{"id":"R2590","pred":"arg1Of","subj":"T3224","obj":"T3234"},{"id":"R2591","pred":"arg2Of","subj":"T3228","obj":"T3227"},{"id":"R2592","pred":"arg1Of","subj":"T3228","obj":"T3229"},{"id":"R2593","pred":"arg1Of","subj":"T3228","obj":"T3232"},{"id":"R2594","pred":"arg2Of","subj":"T3231","obj":"T3229"},{"id":"R2595","pred":"arg1Of","subj":"T3231","obj":"T3230"},{"id":"R2596","pred":"arg2Of","subj":"T3234","obj":"T3232"},{"id":"R2597","pred":"arg1Of","subj":"T3234","obj":"T3233"},{"id":"R2598","pred":"arg2Of","subj":"T3236","obj":"T3234"},{"id":"R2599","pred":"arg1Of","subj":"T3236","obj":"T3235"},{"id":"R17595","pred":"arg1Of","subj":"T23465","obj":"T23464"},{"id":"R17596","pred":"arg1Of","subj":"T23465","obj":"T23466"},{"id":"R17597","pred":"arg1Of","subj":"T23465","obj":"T23468"},{"id":"R17598","pred":"arg2Of","subj":"T23468","obj":"T23466"},{"id":"R17599","pred":"arg1Of","subj":"T23468","obj":"T23467"},{"id":"R17600","pred":"arg2Of","subj":"T23470","obj":"T23468"},{"id":"R17601","pred":"arg1Of","subj":"T23470","obj":"T23469"},{"id":"R17602","pred":"arg2Of","subj":"T23472","obj":"T23471"},{"id":"R17603","pred":"arg3Of","subj":"T23473","obj":"T23471"},{"id":"R17604","pred":"arg1Of","subj":"T23476","obj":"T23471"},{"id":"R17605","pred":"arg1Of","subj":"T23476","obj":"T23474"},{"id":"R17606","pred":"arg1Of","subj":"T23476","obj":"T23475"},{"id":"R17607","pred":"arg1Of","subj":"T23476","obj":"T23477"},{"id":"R17608","pred":"arg2Of","subj":"T23476","obj":"T23478"},{"id":"R17609","pred":"arg2Of","subj":"T23478","obj":"T23477"},{"id":"R17610","pred":"arg1Of","subj":"T23478","obj":"T23479"},{"id":"R17611","pred":"arg1Of","subj":"T23478","obj":"T23482"},{"id":"R17612","pred":"arg1Of","subj":"T23478","obj":"T23484"},{"id":"R17613","pred":"arg1Of","subj":"T23478","obj":"T23486"},{"id":"R17614","pred":"arg2Of","subj":"T23481","obj":"T23479"},{"id":"R17615","pred":"arg1Of","subj":"T23481","obj":"T23480"},{"id":"R17616","pred":"arg1Of","subj":"T23482","obj":"T23483"},{"id":"R17617","pred":"arg2Of","subj":"T23484","obj":"T23483"},{"id":"R17618","pred":"arg2Of","subj":"T23485","obj":"T23482"},{"id":"R17619","pred":"arg2Of","subj":"T23485","obj":"T23484"},{"id":"R17620","pred":"arg2Of","subj":"T23487","obj":"T23486"},{"id":"R17621","pred":"arg1Of","subj":"T23487","obj":"T23488"},{"id":"R17622","pred":"arg2Of","subj":"T23490","obj":"T23488"},{"id":"R17623","pred":"arg1Of","subj":"T23490","obj":"T23489"},{"id":"R17624","pred":"arg1Of","subj":"T23490","obj":"T23491"},{"id":"R17625","pred":"arg1Of","subj":"T23490","obj":"T23492"},{"id":"R17626","pred":"arg2Of","subj":"T23493","obj":"T23492"},{"id":"R17627","pred":"arg3Of","subj":"T23494","obj":"T23492"},{"id":"R17628","pred":"arg1Of","subj":"T23495","obj":"T23496"},{"id":"R17629","pred":"arg2Of","subj":"T23495","obj":"T23497"},{"id":"R17630","pred":"arg2Of","subj":"T23497","obj":"T23496"},{"id":"R17631","pred":"arg1Of","subj":"T23497","obj":"T23498"},{"id":"R17632","pred":"arg1Of","subj":"T23497","obj":"T23501"},{"id":"R17633","pred":"arg2Of","subj":"T23500","obj":"T23498"},{"id":"R17634","pred":"arg1Of","subj":"T23500","obj":"T23499"},{"id":"R17635","pred":"arg1Of","subj":"T23503","obj":"T23502"},{"id":"R17636","pred":"arg1Of","subj":"T23503","obj":"T23504"},{"id":"R17637","pred":"arg2Of","subj":"T23503","obj":"T23505"},{"id":"R17638","pred":"arg2Of","subj":"T23505","obj":"T23501"},{"id":"R17639","pred":"arg2Of","subj":"T23505","obj":"T23504"},{"id":"R17640","pred":"arg1Of","subj":"T23508","obj":"T23505"},{"id":"R17641","pred":"arg2Of","subj":"T23508","obj":"T23506"},{"id":"R17642","pred":"arg1Of","subj":"T23508","obj":"T23507"},{"id":"R17643","pred":"arg1Of","subj":"T23509","obj":"T23510"},{"id":"R17644","pred":"arg2Of","subj":"T23514","obj":"T23510"},{"id":"R17645","pred":"arg1Of","subj":"T23514","obj":"T23511"},{"id":"R17646","pred":"arg1Of","subj":"T23514","obj":"T23512"},{"id":"R17647","pred":"arg1Of","subj":"T23514","obj":"T23513"},{"id":"R17648","pred":"arg1Of","subj":"T23514","obj":"T23515"},{"id":"R17649","pred":"arg2Of","subj":"T23518","obj":"T23515"},{"id":"R17650","pred":"arg1Of","subj":"T23518","obj":"T23516"},{"id":"R17651","pred":"arg1Of","subj":"T23518","obj":"T23517"},{"id":"R17652","pred":"arg2Of","subj":"T23520","obj":"T23519"},{"id":"R17653","pred":"arg3Of","subj":"T23521","obj":"T23519"},{"id":"R17654","pred":"arg1Of","subj":"T23523","obj":"T23522"},{"id":"R17655","pred":"arg1Of","subj":"T23524","obj":"T23523"},{"id":"R17656","pred":"arg1Of","subj":"T23525","obj":"T23526"},{"id":"R17657","pred":"arg1Of","subj":"T23526","obj":"T23529"},{"id":"R17658","pred":"arg2Of","subj":"T23527","obj":"T23526"},{"id":"R17659","pred":"arg1Of","subj":"T23529","obj":"T23528"},{"id":"R17660","pred":"arg2Of","subj":"T23530","obj":"T23529"},{"id":"R17661","pred":"arg1Of","subj":"T23531","obj":"T23519"},{"id":"R17662","pred":"arg1Of","subj":"T23531","obj":"T23524"},{"id":"R17663","pred":"arg1Of","subj":"T23531","obj":"T23525"},{"id":"R17664","pred":"arg1Of","subj":"T23531","obj":"T23527"},{"id":"R17665","pred":"arg1Of","subj":"T23531","obj":"T23530"},{"id":"R17666","pred":"arg1Of","subj":"T23531","obj":"T23532"},{"id":"R17667","pred":"arg2Of","subj":"T23531","obj":"T23533"},{"id":"R17668","pred":"arg2Of","subj":"T23533","obj":"T23532"},{"id":"R17669","pred":"arg1Of","subj":"T23533","obj":"T23534"},{"id":"R17670","pred":"arg1Of","subj":"T23533","obj":"T23541"},{"id":"R17671","pred":"arg1Of","subj":"T23535","obj":"T23536"},{"id":"R17672","pred":"arg1Of","subj":"T23536","obj":"T23539"},{"id":"R17673","pred":"arg2Of","subj":"T23537","obj":"T23536"},{"id":"R17674","pred":"arg2Of","subj":"T23539","obj":"T23534"},{"id":"R17675","pred":"arg1Of","subj":"T23539","obj":"T23538"},{"id":"R17676","pred":"arg2Of","subj":"T23540","obj":"T23539"},{"id":"R17677","pred":"arg2Of","subj":"T23542","obj":"T23541"},{"id":"R17678","pred":"arg1Of","subj":"T23544","obj":"T23543"},{"id":"R17679","pred":"arg1Of","subj":"T23544","obj":"T23545"},{"id":"R17680","pred":"arg1Of","subj":"T23544","obj":"T23548"},{"id":"R17681","pred":"arg2Of","subj":"T23544","obj":"T23549"},{"id":"R17682","pred":"arg2Of","subj":"T23547","obj":"T23545"},{"id":"R17683","pred":"arg1Of","subj":"T23547","obj":"T23546"},{"id":"R17684","pred":"arg2Of","subj":"T23549","obj":"T23548"},{"id":"R17685","pred":"arg1Of","subj":"T23551","obj":"T23552"},{"id":"R17686","pred":"arg2Of","subj":"T23553","obj":"T23552"},{"id":"R17687","pred":"arg1Of","subj":"T23554","obj":"T23549"},{"id":"R17688","pred":"arg2Of","subj":"T23554","obj":"T23550"},{"id":"R17689","pred":"arg1Of","subj":"T23554","obj":"T23551"},{"id":"R17690","pred":"arg1Of","subj":"T23554","obj":"T23553"},{"id":"R17691","pred":"arg1Of","subj":"T23554","obj":"T23555"},{"id":"R17692","pred":"arg2Of","subj":"T23557","obj":"T23555"},{"id":"R17693","pred":"arg1Of","subj":"T23557","obj":"T23556"},{"id":"R17694","pred":"arg3Of","subj":"T23558","obj":"T23555"},{"id":"R17695","pred":"arg1Of","subj":"T23559","obj":"T23560"},{"id":"R17696","pred":"arg2Of","subj":"T23564","obj":"T23560"},{"id":"R17697","pred":"arg1Of","subj":"T23564","obj":"T23561"},{"id":"R17698","pred":"arg1Of","subj":"T23564","obj":"T23562"},{"id":"R17699","pred":"arg1Of","subj":"T23564","obj":"T23563"},{"id":"R17700","pred":"arg1Of","subj":"T23564","obj":"T23565"},{"id":"R17701","pred":"arg2Of","subj":"T23568","obj":"T23565"},{"id":"R17702","pred":"arg1Of","subj":"T23568","obj":"T23566"},{"id":"R17703","pred":"arg1Of","subj":"T23568","obj":"T23567"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T3907","span":{"begin":0,"end":3},"obj":"CD"},{"id":"T3908","span":{"begin":4,"end":9},"obj":"NNS"},{"id":"T3909","span":{"begin":580,"end":583},"obj":"VBP"},{"id":"T3910","span":{"begin":584,"end":589},"obj":"VBN"},{"id":"T3911","span":{"begin":590,"end":592},"obj":"TO"},{"id":"T3912","span":{"begin":593,"end":600},"obj":"VB"},{"id":"T3913","span":{"begin":601,"end":605},"obj":"NN"},{"id":"T3914","span":{"begin":606,"end":610},"obj":"IN"},{"id":"T3915","span":{"begin":611,"end":621},"obj":"NN"},{"id":"T3916","span":{"begin":621,"end":622},"obj":","},{"id":"T3917","span":{"begin":623,"end":628},"obj":"WDT"},{"id":"T3918","span":{"begin":629,"end":632},"obj":"MD"},{"id":"T3919","span":{"begin":633,"end":641},"obj":"VB"},{"id":"T3920","span":{"begin":642,"end":646},"obj":"IN"},{"id":"T3921","span":{"begin":647,"end":652},"obj":"JJ"},{"id":"T3922","span":{"begin":653,"end":662},"obj":"VBG"},{"id":"T3923","span":{"begin":663,"end":666},"obj":"CC"},{"id":"T3924","span":{"begin":667,"end":671},"obj":"RB"},{"id":"T3925","span":{"begin":672,"end":679},"obj":"VB"},{"id":"T3926","span":{"begin":680,"end":685},"obj":"CD"},{"id":"T3927","span":{"begin":686,"end":695},"obj":"NN"},{"id":"T3928","span":{"begin":695,"end":696},"obj":"."},{"id":"T23591","span":{"begin":0,"end":3},"obj":"CD"},{"id":"T23592","span":{"begin":4,"end":9},"obj":"NNP"},{"id":"T23593","span":{"begin":10,"end":13},"obj":"MD"},{"id":"T23594","span":{"begin":13,"end":16},"obj":"RB"},{"id":"T23595","span":{"begin":17,"end":23},"obj":"VB"},{"id":"T23596","span":{"begin":24,"end":29},"obj":"NNP"},{"id":"T23597","span":{"begin":30,"end":40},"obj":"NNP"},{"id":"T23598","span":{"begin":41,"end":42},"obj":"-LRB-"},{"id":"T23599","span":{"begin":42,"end":43},"obj":"NNP"},{"id":"T23600","span":{"begin":43,"end":44},"obj":"-RRB-"},{"id":"T23601","span":{"begin":45,"end":50},"obj":"NNP"},{"id":"T23602","span":{"begin":51,"end":52},"obj":"NNP"},{"id":"T23603","span":{"begin":53,"end":58},"obj":"NNS"},{"id":"T23604","span":{"begin":59,"end":63},"obj":"VBD"},{"id":"T23605","span":{"begin":64,"end":73},"obj":"VBN"},{"id":"T23606","span":{"begin":74,"end":78},"obj":"IN"},{"id":"T23607","span":{"begin":79,"end":90},"obj":"JJ"},{"id":"T23608","span":{"begin":91,"end":99},"obj":"JJ"},{"id":"T23609","span":{"begin":99,"end":100},"obj":"NN"},{"id":"T23610","span":{"begin":100,"end":104},"obj":"CD"},{"id":"T23611","span":{"begin":105,"end":109},"obj":"IN"},{"id":"T23612","span":{"begin":110,"end":112},"obj":"CC"},{"id":"T23613","span":{"begin":113,"end":120},"obj":"IN"},{"id":"T23614","span":{"begin":121,"end":126},"obj":"NNP"},{"id":"T23615","span":{"begin":127,"end":129},"obj":"IN"},{"id":"T23616","span":{"begin":130,"end":139},"obj":"VBN"},{"id":"T23617","span":{"begin":140,"end":142},"obj":"IN"},{"id":"T23618","span":{"begin":143,"end":146},"obj":"DT"},{"id":"T23619","span":{"begin":147,"end":153},"obj":"NNS"},{"id":"T23620","span":{"begin":154,"end":156},"obj":"IN"},{"id":"T23621","span":{"begin":157,"end":158},"obj":"-LRB-"},{"id":"T23622","span":{"begin":158,"end":159},"obj":"NNP"},{"id":"T23623","span":{"begin":159,"end":160},"obj":"-RRB-"},{"id":"T23624","span":{"begin":160,"end":161},"obj":"."},{"id":"T23625","span":{"begin":162,"end":167},"obj":"NNS"},{"id":"T23626","span":{"begin":168,"end":172},"obj":"VBD"},{"id":"T23627","span":{"begin":173,"end":182},"obj":"VBN"},{"id":"T23628","span":{"begin":183,"end":188},"obj":"IN"},{"id":"T23629","span":{"begin":189,"end":190},"obj":"CD"},{"id":"T23630","span":{"begin":191,"end":195},"obj":"NNS"},{"id":"T23631","span":{"begin":196,"end":199},"obj":"CC"},{"id":"T23632","span":{"begin":200,"end":205},"obj":"CD"},{"id":"T23633","span":{"begin":206,"end":210},"obj":"NNP"},{"id":"T23634","span":{"begin":211,"end":214},"obj":"VBD"},{"id":"T23635","span":{"begin":215,"end":225},"obj":"VBN"},{"id":"T23636","span":{"begin":226,"end":228},"obj":"IN"},{"id":"T23637","span":{"begin":229,"end":238},"obj":"JJ"},{"id":"T23638","span":{"begin":239,"end":242},"obj":"NNP"},{"id":"T23639","span":{"begin":242,"end":243},"obj":"."},{"id":"T23640","span":{"begin":244,"end":248},"obj":"NNS"},{"id":"T23641","span":{"begin":249,"end":253},"obj":"VBP"},{"id":"T23642","span":{"begin":254,"end":257},"obj":"DT"},{"id":"T23643","span":{"begin":258,"end":262},"obj":"JJ"},{"id":"T23644","span":{"begin":263,"end":264},"obj":"NN"},{"id":"T23645","span":{"begin":265,"end":267},"obj":"NNP"},{"id":"T23646","span":{"begin":268,"end":270},"obj":"IN"},{"id":"T23647","span":{"begin":271,"end":272},"obj":"CD"},{"id":"T23648","span":{"begin":273,"end":284},"obj":"JJ"},{"id":"T23649","span":{"begin":285,"end":296},"obj":"NNS"},{"id":"T23650","span":{"begin":296,"end":297},"obj":"."},{"id":"T23651","span":{"begin":298,"end":299},"obj":"-LRB-"},{"id":"T23652","span":{"begin":299,"end":300},"obj":"NNP"},{"id":"T23653","span":{"begin":300,"end":301},"obj":"-RRB-"},{"id":"T23654","span":{"begin":302,"end":304},"obj":"IN"},{"id":"T23655","span":{"begin":305,"end":310},"obj":"NN"},{"id":"T23656","span":{"begin":311,"end":325},"obj":"VBN"},{"id":"T23657","span":{"begin":326,"end":329},"obj":"NNP"},{"id":"T23658","span":{"begin":329,"end":330},"obj":","},{"id":"T23659","span":{"begin":331,"end":334},"obj":"NNP"},{"id":"T23660","span":{"begin":334,"end":335},"obj":","},{"id":"T23661","span":{"begin":336,"end":338},"obj":"CC"},{"id":"T23662","span":{"begin":339,"end":344},"obj":"NNP"},{"id":"T23663","span":{"begin":345,"end":350},"obj":"NNS"},{"id":"T23664","span":{"begin":351,"end":355},"obj":"VBD"},{"id":"T23665","span":{"begin":356,"end":365},"obj":"VBN"},{"id":"T23666","span":{"begin":366,"end":370},"obj":"IN"},{"id":"T23667","span":{"begin":371,"end":379},"obj":"JJ"},{"id":"T23668","span":{"begin":379,"end":380},"obj":"NN"},{"id":"T23669","span":{"begin":380,"end":384},"obj":"NNP"},{"id":"T23670","span":{"begin":384,"end":385},"obj":","},{"id":"T23671","span":{"begin":386,"end":391},"obj":"NNP"},{"id":"T23672","span":{"begin":391,"end":392},"obj":","},{"id":"T23673","span":{"begin":393,"end":395},"obj":"CC"},{"id":"T23674","span":{"begin":396,"end":405},"obj":"JJ"},{"id":"T23675","span":{"begin":406,"end":408},"obj":"IN"},{"id":"T23676","span":{"begin":409,"end":418},"obj":"VBN"},{"id":"T23677","span":{"begin":418,"end":419},"obj":"."},{"id":"T23678","span":{"begin":420,"end":423},"obj":"DT"},{"id":"T23679","span":{"begin":424,"end":433},"obj":"NN"},{"id":"T23680","span":{"begin":434,"end":436},"obj":"IN"},{"id":"T23681","span":{"begin":437,"end":442},"obj":"DT"},{"id":"T23682","span":{"begin":443,"end":448},"obj":"NNS"},{"id":"T23683","span":{"begin":449,"end":452},"obj":"VBD"},{"id":"T23684","span":{"begin":453,"end":462},"obj":"VBN"},{"id":"T23685","span":{"begin":463,"end":465},"obj":"IN"},{"id":"T23686","span":{"begin":466,"end":470},"obj":"NNP"},{"id":"T23687","span":{"begin":471,"end":474},"obj":"CC"},{"id":"T23688","span":{"begin":475,"end":488},"obj":"NN"},{"id":"T23689","span":{"begin":489,"end":497},"obj":"NN"},{"id":"T23690","span":{"begin":498,"end":499},"obj":"-LRB-"},{"id":"T23691","span":{"begin":499,"end":505},"obj":"NN"},{"id":"T23692","span":{"begin":506,"end":508},"obj":"CD"},{"id":"T23693","span":{"begin":508,"end":509},"obj":"-RRB-"},{"id":"T23694","span":{"begin":509,"end":510},"obj":"."},{"id":"T23695","span":{"begin":511,"end":515},"obj":"NNS"},{"id":"T23696","span":{"begin":516,"end":520},"obj":"VBP"},{"id":"T23697","span":{"begin":521,"end":524},"obj":"DT"},{"id":"T23698","span":{"begin":525,"end":529},"obj":"JJ"},{"id":"T23699","span":{"begin":530,"end":531},"obj":"NN"},{"id":"T23700","span":{"begin":532,"end":534},"obj":"NNP"},{"id":"T23701","span":{"begin":535,"end":537},"obj":"IN"},{"id":"T23702","span":{"begin":538,"end":542},"obj":"CD"},{"id":"T23703","span":{"begin":543,"end":554},"obj":"JJ"},{"id":"T23704","span":{"begin":555,"end":566},"obj":"NNS"},{"id":"T23705","span":{"begin":566,"end":567},"obj":"."}],"relations":[{"id":"R3164","pred":"nummod","subj":"T3907","obj":"T3908"},{"id":"R3169","pred":"nsubjpass","subj":"T3908","obj":"T3910"},{"id":"R3174","pred":"auxpass","subj":"T3909","obj":"T3910"},{"id":"R3177","pred":"ROOT","subj":"T3910","obj":"T3910"},{"id":"R3181","pred":"aux","subj":"T3911","obj":"T3912"},{"id":"R3184","pred":"xcomp","subj":"T3912","obj":"T3910"},{"id":"R3185","pred":"dobj","subj":"T3913","obj":"T3912"},{"id":"R3186","pred":"prep","subj":"T3914","obj":"T3912"},{"id":"R3187","pred":"pobj","subj":"T3915","obj":"T3914"},{"id":"R3188","pred":"punct","subj":"T3916","obj":"T3915"},{"id":"R3189","pred":"nsubj","subj":"T3917","obj":"T3919"},{"id":"R3190","pred":"aux","subj":"T3918","obj":"T3919"},{"id":"R3192","pred":"relcl","subj":"T3919","obj":"T3915"},{"id":"R3195","pred":"prep","subj":"T3920","obj":"T3919"},{"id":"R3199","pred":"amod","subj":"T3921","obj":"T3922"},{"id":"R3202","pred":"pobj","subj":"T3922","obj":"T3920"},{"id":"R3206","pred":"cc","subj":"T3923","obj":"T3922"},{"id":"R3211","pred":"advmod","subj":"T3924","obj":"T3925"},{"id":"R3215","pred":"conj","subj":"T3925","obj":"T3919"},{"id":"R3221","pred":"nummod","subj":"T3926","obj":"T3927"},{"id":"R3225","pred":"dobj","subj":"T3927","obj":"T3925"},{"id":"R3228","pred":"punct","subj":"T3928","obj":"T3910"},{"id":"R17704","pred":"npadvmod","subj":"T23591","obj":"T23595"},{"id":"R17705","pred":"nsubj","subj":"T23592","obj":"T23595"},{"id":"R17706","pred":"aux","subj":"T23593","obj":"T23595"},{"id":"R17707","pred":"neg","subj":"T23594","obj":"T23595"},{"id":"R17708","pred":"ROOT","subj":"T23595","obj":"T23595"},{"id":"R17709","pred":"compound","subj":"T23596","obj":"T23597"},{"id":"R17710","pred":"dobj","subj":"T23597","obj":"T23595"},{"id":"R17711","pred":"punct","subj":"T23598","obj":"T23597"},{"id":"R17712","pred":"appos","subj":"T23599","obj":"T23597"},{"id":"R17713","pred":"punct","subj":"T23600","obj":"T23599"},{"id":"R17714","pred":"compound","subj":"T23601","obj":"T23602"},{"id":"R17715","pred":"compound","subj":"T23602","obj":"T23603"},{"id":"R17716","pred":"nsubjpass","subj":"T23603","obj":"T23605"},{"id":"R17717","pred":"auxpass","subj":"T23604","obj":"T23605"},{"id":"R17718","pred":"ccomp","subj":"T23605","obj":"T23595"},{"id":"R17719","pred":"prep","subj":"T23606","obj":"T23605"},{"id":"R17720","pred":"nmod","subj":"T23607","obj":"T23609"},{"id":"R17721","pred":"amod","subj":"T23608","obj":"T23609"},{"id":"R17722","pred":"pobj","subj":"T23609","obj":"T23606"},{"id":"R17723","pred":"nummod","subj":"T23610","obj":"T23609"},{"id":"R17724","pred":"conj","subj":"T23611","obj":"T23606"},{"id":"R17725","pred":"cc","subj":"T23612","obj":"T23611"},{"id":"R17726","pred":"conj","subj":"T23613","obj":"T23611"},{"id":"R17727","pred":"pobj","subj":"T23614","obj":"T23613"},{"id":"R17728","pred":"mark","subj":"T23615","obj":"T23616"},{"id":"R17729","pred":"advcl","subj":"T23616","obj":"T23605"},{"id":"R17730","pred":"prep","subj":"T23617","obj":"T23616"},{"id":"R17731","pred":"det","subj":"T23618","obj":"T23619"},{"id":"R17732","pred":"pobj","subj":"T23619","obj":"T23617"},{"id":"R17733","pred":"prep","subj":"T23620","obj":"T23619"},{"id":"R17734","pred":"punct","subj":"T23621","obj":"T23622"},{"id":"R17735","pred":"pobj","subj":"T23622","obj":"T23620"},{"id":"R17736","pred":"punct","subj":"T23623","obj":"T23622"},{"id":"R17737","pred":"punct","subj":"T23624","obj":"T23595"},{"id":"R17738","pred":"nsubjpass","subj":"T23625","obj":"T23627"},{"id":"R17739","pred":"auxpass","subj":"T23626","obj":"T23627"},{"id":"R17740","pred":"ROOT","subj":"T23627","obj":"T23627"},{"id":"R17741","pred":"prep","subj":"T23628","obj":"T23627"},{"id":"R17742","pred":"nummod","subj":"T23629","obj":"T23630"},{"id":"R17743","pred":"pobj","subj":"T23630","obj":"T23628"},{"id":"R17744","pred":"cc","subj":"T23631","obj":"T23630"},{"id":"R17745","pred":"nummod","subj":"T23632","obj":"T23633"},{"id":"R17746","pred":"conj","subj":"T23633","obj":"T23630"},{"id":"R17747","pred":"auxpass","subj":"T23634","obj":"T23635"},{"id":"R17748","pred":"conj","subj":"T23635","obj":"T23627"},{"id":"R17749","pred":"agent","subj":"T23636","obj":"T23635"},{"id":"R17750","pred":"amod","subj":"T23637","obj":"T23638"},{"id":"R17751","pred":"pobj","subj":"T23638","obj":"T23636"},{"id":"R17752","pred":"punct","subj":"T23639","obj":"T23627"},{"id":"R17753","pred":"nsubj","subj":"T23640","obj":"T23641"},{"id":"R17754","pred":"ROOT","subj":"T23641","obj":"T23641"},{"id":"R17755","pred":"det","subj":"T23642","obj":"T23645"},{"id":"R17756","pred":"amod","subj":"T23643","obj":"T23645"},{"id":"R17757","pred":"compound","subj":"T23644","obj":"T23645"},{"id":"R17758","pred":"dobj","subj":"T23645","obj":"T23641"},{"id":"R17759","pred":"prep","subj":"T23646","obj":"T23645"},{"id":"R17760","pred":"nummod","subj":"T23647","obj":"T23649"},{"id":"R17761","pred":"amod","subj":"T23648","obj":"T23649"},{"id":"R17762","pred":"pobj","subj":"T23649","obj":"T23646"},{"id":"R17763","pred":"punct","subj":"T23650","obj":"T23641"},{"id":"R17764","pred":"punct","subj":"T23651","obj":"T23652"},{"id":"R17765","pred":"ROOT","subj":"T23652","obj":"T23652"},{"id":"R17766","pred":"punct","subj":"T23653","obj":"T23652"},{"id":"R17767","pred":"prep","subj":"T23654","obj":"T23665"},{"id":"R17768","pred":"pobj","subj":"T23655","obj":"T23654"},{"id":"R17769","pred":"amod","subj":"T23656","obj":"T23657"},{"id":"R17770","pred":"nmod","subj":"T23657","obj":"T23663"},{"id":"R17771","pred":"punct","subj":"T23658","obj":"T23659"},{"id":"R17772","pred":"conj","subj":"T23659","obj":"T23657"},{"id":"R17773","pred":"punct","subj":"T23660","obj":"T23659"},{"id":"R17774","pred":"cc","subj":"T23661","obj":"T23659"},{"id":"R17775","pred":"conj","subj":"T23662","obj":"T23659"},{"id":"R17776","pred":"nsubjpass","subj":"T23663","obj":"T23665"},{"id":"R17777","pred":"auxpass","subj":"T23664","obj":"T23665"},{"id":"R17778","pred":"ROOT","subj":"T23665","obj":"T23665"},{"id":"R17779","pred":"prep","subj":"T23666","obj":"T23665"},{"id":"R17780","pred":"amod","subj":"T23667","obj":"T23669"},{"id":"R17781","pred":"compound","subj":"T23668","obj":"T23669"},{"id":"R17782","pred":"pobj","subj":"T23669","obj":"T23666"},{"id":"R17783","pred":"punct","subj":"T23670","obj":"T23669"},{"id":"R17784","pred":"conj","subj":"T23671","obj":"T23669"},{"id":"R17785","pred":"punct","subj":"T23672","obj":"T23671"},{"id":"R17786","pred":"cc","subj":"T23673","obj":"T23671"},{"id":"R17787","pred":"conj","subj":"T23674","obj":"T23671"},{"id":"R17788","pred":"mark","subj":"T23675","obj":"T23676"},{"id":"R17789","pred":"advcl","subj":"T23676","obj":"T23665"},{"id":"R17790","pred":"punct","subj":"T23677","obj":"T23665"},{"id":"R17791","pred":"det","subj":"T23678","obj":"T23679"},{"id":"R17792","pred":"nsubjpass","subj":"T23679","obj":"T23684"},{"id":"R17793","pred":"prep","subj":"T23680","obj":"T23679"},{"id":"R17794","pred":"det","subj":"T23681","obj":"T23682"},{"id":"R17795","pred":"pobj","subj":"T23682","obj":"T23680"},{"id":"R17796","pred":"auxpass","subj":"T23683","obj":"T23684"},{"id":"R17797","pred":"ROOT","subj":"T23684","obj":"T23684"},{"id":"R17798","pred":"agent","subj":"T23685","obj":"T23684"},{"id":"R17799","pred":"pobj","subj":"T23686","obj":"T23685"},{"id":"R17800","pred":"cc","subj":"T23687","obj":"T23686"},{"id":"R17801","pred":"compound","subj":"T23688","obj":"T23689"},{"id":"R17802","pred":"conj","subj":"T23689","obj":"T23686"},{"id":"R17803","pred":"punct","subj":"T23690","obj":"T23691"},{"id":"R17804","pred":"appos","subj":"T23691","obj":"T23689"},{"id":"R17805","pred":"nummod","subj":"T23692","obj":"T23691"},{"id":"R17806","pred":"punct","subj":"T23693","obj":"T23691"},{"id":"R17807","pred":"punct","subj":"T23694","obj":"T23684"},{"id":"R17808","pred":"nsubj","subj":"T23695","obj":"T23696"},{"id":"R17809","pred":"ROOT","subj":"T23696","obj":"T23696"},{"id":"R17810","pred":"det","subj":"T23697","obj":"T23700"},{"id":"R17811","pred":"amod","subj":"T23698","obj":"T23700"},{"id":"R17812","pred":"compound","subj":"T23699","obj":"T23700"},{"id":"R17813","pred":"dobj","subj":"T23700","obj":"T23696"},{"id":"R17814","pred":"prep","subj":"T23701","obj":"T23700"},{"id":"R17815","pred":"nummod","subj":"T23702","obj":"T23704"},{"id":"R17816","pred":"amod","subj":"T23703","obj":"T23704"},{"id":"R17817","pred":"pobj","subj":"T23704","obj":"T23701"},{"id":"R17818","pred":"punct","subj":"T23705","obj":"T23696"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}

{"project":"GO-BP","denotations":[{"id":"T2893","span":{"begin":653,"end":662},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}

{"project":"GO-MF","denotations":[{"id":"T23717","span":{"begin":401,"end":405},"obj":"http://purl.obolibrary.org/obo/GO_0005136"},{"id":"T4442","span":{"begin":601,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0005136"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}

{"project":"GO-CC","denotations":[{"id":"T4464","span":{"begin":4,"end":9},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T23718","span":{"begin":53,"end":58},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T23719","span":{"begin":345,"end":350},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T23720","span":{"begin":443,"end":448},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}

{"project":"sentences","denotations":[{"id":"T2873","span":{"begin":0,"end":696},"obj":"Sentence"},{"id":"T23457","span":{"begin":0,"end":40},"obj":"Sentence"},{"id":"T23458","span":{"begin":41,"end":161},"obj":"Sentence"},{"id":"T23459","span":{"begin":162,"end":243},"obj":"Sentence"},{"id":"T23460","span":{"begin":244,"end":297},"obj":"Sentence"},{"id":"T23461","span":{"begin":298,"end":419},"obj":"Sentence"},{"id":"T23462","span":{"begin":420,"end":510},"obj":"Sentence"},{"id":"T23463","span":{"begin":511,"end":567},"obj":"Sentence"},{"id":"T52","span":{"begin":41,"end":161},"obj":"Sentence"},{"id":"T53","span":{"begin":162,"end":243},"obj":"Sentence"},{"id":"T54","span":{"begin":244,"end":297},"obj":"Sentence"},{"id":"T55","span":{"begin":298,"end":419},"obj":"Sentence"},{"id":"T56","span":{"begin":420,"end":510},"obj":"Sentence"},{"id":"T57","span":{"begin":511,"end":567},"obj":"Sentence"},{"id":"T58","span":{"begin":570,"end":696},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}

{"project":"events-check-again","denotations":[{"id":"T4871","span":{"begin":593,"end":600},"obj":"Gene_expression"},{"id":"T4872","span":{"begin":601,"end":605},"obj":"Protein"},{"id":"T4873","span":{"begin":647,"end":652},"obj":"Protein"},{"id":"T4874","span":{"begin":672,"end":679},"obj":"Negative_regulation"},{"id":"T4875","span":{"begin":680,"end":685},"obj":"Protein"},{"id":"T4876","span":{"begin":686,"end":695},"obj":"Positive_regulation"},{"id":"T23765","span":{"begin":17,"end":23},"obj":"Positive_regulation"},{"id":"T23766","span":{"begin":24,"end":29},"obj":"Protein"},{"id":"T23767","span":{"begin":30,"end":40},"obj":"Gene_expression"},{"id":"T23768","span":{"begin":96,"end":99},"obj":"Protein"},{"id":"T23769","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T23770","span":{"begin":121,"end":126},"obj":"Protein"},{"id":"T23771","span":{"begin":200,"end":205},"obj":"Protein"},{"id":"T23772","span":{"begin":376,"end":379},"obj":"Protein"},{"id":"T23773","span":{"begin":380,"end":384},"obj":"Protein"},{"id":"T23774","span":{"begin":386,"end":391},"obj":"Protein"},{"id":"T23775","span":{"begin":401,"end":405},"obj":"Protein"}],"relations":[{"id":"R3856","pred":"themeOf","subj":"T4872","obj":"T4871"},{"id":"R3857","pred":"causeOf","subj":"T4872","obj":"T4874"},{"id":"R3859","pred":"themeOf","subj":"T4875","obj":"T4876"},{"id":"R3862","pred":"themeOf","subj":"T4876","obj":"T4874"},{"id":"R17831","pred":"themeOf","subj":"T23766","obj":"T23767"},{"id":"R17832","pred":"themeOf","subj":"T23767","obj":"T23765"}],"attributes":[{"id":"M497","pred":"Negation","subj":"T23765","obj":"true"},{"id":"M87","pred":"Speculation","subj":"T4874","obj":"true"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T23721","span":{"begin":91,"end":99},"obj":"Protein"},{"id":"T23722","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T23723","span":{"begin":121,"end":126},"obj":"Protein"},{"id":"T23724","span":{"begin":200,"end":210},"obj":"Protein"},{"id":"T23725","span":{"begin":371,"end":379},"obj":"Protein"},{"id":"T23726","span":{"begin":380,"end":384},"obj":"Protein"},{"id":"T23727","span":{"begin":386,"end":391},"obj":"Protein"},{"id":"T23728","span":{"begin":396,"end":405},"obj":"Protein"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T2903","span":{"begin":593,"end":600},"obj":"Gene_expression"},{"id":"T2904","span":{"begin":672,"end":679},"obj":"Negative_regulation"},{"id":"T2905","span":{"begin":686,"end":695},"obj":"Positive_regulation"},{"id":"T2961","span":{"begin":601,"end":605},"obj":"Protein"},{"id":"T2962","span":{"begin":647,"end":652},"obj":"Protein"},{"id":"T2963","span":{"begin":680,"end":685},"obj":"Protein"},{"id":"T23452","span":{"begin":200,"end":205},"obj":"Protein"},{"id":"T23453","span":{"begin":376,"end":379},"obj":"Protein"},{"id":"T23454","span":{"begin":380,"end":384},"obj":"Protein"},{"id":"T23455","span":{"begin":386,"end":391},"obj":"Protein"},{"id":"T23456","span":{"begin":401,"end":405},"obj":"Protein"},{"id":"T23446","span":{"begin":17,"end":23},"obj":"Positive_regulation"},{"id":"T23447","span":{"begin":24,"end":29},"obj":"Protein"},{"id":"T23448","span":{"begin":30,"end":40},"obj":"Gene_expression"},{"id":"T23449","span":{"begin":96,"end":99},"obj":"Protein"},{"id":"T23450","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T23451","span":{"begin":121,"end":126},"obj":"Protein"}],"relations":[{"id":"R17593","pred":"themeOf","subj":"T23447","obj":"T23448"},{"id":"R17594","pred":"themeOf","subj":"T23448","obj":"T23446"},{"id":"R2313","pred":"themeOf","subj":"T2905","obj":"T2904"},{"id":"R2331","pred":"themeOf","subj":"T2961","obj":"T2903"},{"id":"R2332","pred":"causeOf","subj":"T2961","obj":"T2904"},{"id":"R2333","pred":"themeOf","subj":"T2963","obj":"T2905"}],"attributes":[{"id":"M492","pred":"Negation","subj":"T23446","obj":"true"},{"id":"M38","pred":"Speculation","subj":"T2904","obj":"true"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T3617","span":{"begin":601,"end":605},"obj":"P05112"},{"id":"T3618","span":{"begin":647,"end":652},"obj":"P01137"},{"id":"T3619","span":{"begin":680,"end":685},"obj":"Q9BZS1"},{"id":"T23569","span":{"begin":24,"end":29},"obj":"Q9BZS1"},{"id":"T23570","span":{"begin":96,"end":99},"obj":"P04234"},{"id":"T23571","span":{"begin":96,"end":99},"obj":"P20963"},{"id":"T23572","span":{"begin":96,"end":99},"obj":"P09693"},{"id":"T23573","span":{"begin":96,"end":99},"obj":"P07766"},{"id":"T23574","span":{"begin":100,"end":104},"obj":"P10747"},{"id":"T23575","span":{"begin":121,"end":126},"obj":"P01137"},{"id":"T23576","span":{"begin":200,"end":205},"obj":"Q9BZS1"},{"id":"T23577","span":{"begin":376,"end":379},"obj":"P09693"},{"id":"T23578","span":{"begin":376,"end":379},"obj":"P20963"},{"id":"T23579","span":{"begin":376,"end":379},"obj":"P07766"},{"id":"T23580","span":{"begin":376,"end":379},"obj":"P04234"},{"id":"T23581","span":{"begin":380,"end":384},"obj":"P10747"},{"id":"T23582","span":{"begin":386,"end":391},"obj":"P01137"},{"id":"T23583","span":{"begin":401,"end":405},"obj":"P05112"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}

{"project":"test2","denotations":[{"id":"T2777","span":{"begin":593,"end":600},"obj":"Gene_expression"},{"id":"T2778","span":{"begin":601,"end":605},"obj":"Protein"},{"id":"T2779","span":{"begin":611,"end":621},"obj":"Positive_regulation"},{"id":"T2780","span":{"begin":633,"end":641},"obj":"Binding"},{"id":"T2781","span":{"begin":647,"end":652},"obj":"Protein"},{"id":"T2782","span":{"begin":672,"end":679},"obj":"Negative_regulation"},{"id":"T2783","span":{"begin":680,"end":685},"obj":"Protein"},{"id":"T2784","span":{"begin":686,"end":695},"obj":"Positive_regulation"},{"id":"T23439","span":{"begin":17,"end":23},"obj":"Positive_regulation"},{"id":"T23440","span":{"begin":24,"end":29},"obj":"Protein"},{"id":"T23441","span":{"begin":30,"end":40},"obj":"Gene_expression"},{"id":"T23442","span":{"begin":96,"end":99},"obj":"Protein"},{"id":"T23443","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T23444","span":{"begin":121,"end":126},"obj":"Protein"},{"id":"T23445","span":{"begin":200,"end":205},"obj":"Protein"}],"relations":[{"id":"R2267","pred":"causeOf","subj":"T2778","obj":"T2782"},{"id":"R2268","pred":"themeOf","subj":"T2778","obj":"T2777"},{"id":"R2269","pred":"themeOf","subj":"T2778","obj":"T2780"},{"id":"R2270","pred":"causeOf","subj":"T2780","obj":"T2782"},{"id":"R2271","pred":"themeOf","subj":"T2783","obj":"T2784"},{"id":"R2272","pred":"themeOf","subj":"T2784","obj":"T2782"},{"id":"R17591","pred":"themeOf","subj":"T23440","obj":"T23441"},{"id":"R17592","pred":"themeOf","subj":"T23441","obj":"T23439"}],"attributes":[{"id":"M33","pred":"Speculation","subj":"T2782","obj":"true"},{"id":"M491","pred":"Negation","subj":"T23439","obj":"true"},{"id":"M34","pred":"Negation","subj":"T2784","obj":"true"},{"id":"M32","pred":"Speculation","subj":"T2781","obj":"true"}],"text":"Th2 Cells Cannot Induce FOXP3 Expression\n(A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments.\n(B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction."}