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PMC:2222968 / 6284-11404 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T3016 0-5 NN denotes FOXP3
T3017 6-15 NN denotes Induction
T3018 16-18 IN denotes in
T3019 19-20 NN denotes T
T3020 21-25 NN denotes Cell
T3021 26-33 NN denotes Subsets
T3022 34-36 PRP denotes It
T3023 37-39 VB denotes is
T3024 40-47 VB denotes assumed
T3025 48-52 IN denotes that
T3026 53-58 NN denotes FOXP3
T3027 59-69 NN denotes expression
T3028 70-73 MD denotes can
T3029 74-76 VB denotes be
T3030 77-84 VB denotes induced
T3031 85-87 IN denotes in
T3032 88-101 JJ denotes nonregulatory
T3033 102-103 NN denotes T
T3034 104-109 NN denotes cells
T3035 109-110 -COMMA- denotes ,
T3036 111-116 WDT denotes which
T3037 117-119 VB denotes is
T3038 120-122 DT denotes an
T3039 123-132 JJ denotes important
T3040 133-137 NN denotes step
T3041 138-140 IN denotes in
T3042 141-146 NN denotes iTreg
T3043 147-151 NN denotes cell
T3044 152-167 NN denotes differentiation
T3045 169-176 RB denotes However
T3046 176-177 -COMMA- denotes ,
T3047 178-180 PRP denotes it
T3048 181-183 VB denotes is
T3049 184-187 RB denotes not
T3050 188-193 VB denotes known
T3051 194-196 IN denotes if
T3052 197-200 DT denotes all
T3053 201-205 JJ denotes CD4+
T3054 206-207 NN denotes T
T3055 208-213 NN denotes cells
T3056 214-218 VB denotes have
T3057 219-222 DT denotes the
T3058 223-227 JJ denotes same
T3059 228-236 NN denotes capacity
T3060 237-239 TO denotes to
T3061 240-247 VB denotes express
T3062 248-253 NN denotes FOXP3
T3063 255-257 TO denotes To
T3064 258-269 VB denotes investigate
T3065 270-277 IN denotes whether
T3066 278-283 NN denotes FOXP3
T3067 284-287 MD denotes can
T3068 288-290 VB denotes be
T3069 291-300 VB denotes expressed
T3070 301-303 IN denotes by
T3071 304-307 DT denotes any
T3072 308-309 NN denotes T
T3073 310-314 NN denotes cell
T3074 315-321 NN denotes subset
T3075 322-324 CC denotes or
T3076 325-327 IN denotes if
T3077 328-338 NN denotes expression
T3078 339-341 VB denotes is
T3079 342-352 JJ denotes restricted
T3080 353-355 TO denotes to
T3081 356-357 DT denotes a
T3082 358-366 JJ denotes distinct
T3083 367-374 NN denotes lineage
T3084 374-375 -COMMA- denotes ,
T3085 376-381 NN denotes FOXP3
T3086 382-386 NN denotes mRNA
T3087 387-397 NN denotes expression
T3088 398-401 VB denotes was
T3089 402-410 VB denotes analyzed
T3090 411-413 IN denotes in
T3091 414-421 RB denotes freshly
T3092 422-430 VB denotes isolated
T3093 431-432 NN denotes T
T3094 433-438 NN denotes cells
T3095 439-443 JJ denotes such
T3096 444-446 IN denotes as
T3097 447-460 JJ denotes CD25-depleted
T3098 461-465 JJ denotes CD4+
T3099 466-471 NN denotes cells
T3100 471-472 -COMMA- denotes ,
T3101 473-480 JJ denotes CD45RA+
T3102 481-486 JJ denotes naive
T3103 487-489 CC denotes or
T3104 490-497 JJ denotes CD45RO+
T3105 498-504 NN denotes memory
T3106 505-506 NN denotes T
T3107 507-512 NN denotes cells
T3108 513-514 -LRB- denotes (
T3109 514-520 NN denotes Figure
T3110 521-523 NN denotes 1A
T3111 523-524 -RRB- denotes )
T3112 524-525 -COMMA- denotes ,
T3113 526-528 RB denotes as
T3114 529-533 RB denotes well
T3115 534-536 IN denotes as
T3116 537-538 NN denotes T
T3117 539-544 NN denotes cells
T3118 545-551 VB denotes driven
T3119 552-554 FW denotes in
T3120 555-560 FW denotes vitro
T3121 561-567 IN denotes toward
T3122 568-571 NN denotes Th1
T3123 571-572 -COMMA- denotes ,
T3124 573-576 NN denotes Th2
T3125 576-577 -COMMA- denotes ,
T3126 578-580 CC denotes or
T3127 581-586 NN denotes iTreg
T3128 587-597 NN denotes phenotypes
T3129 598-599 -LRB- denotes (
T3130 599-605 NN denotes Figure
T3131 606-608 NN denotes 1B
T3132 608-609 -COLON- denotes ;
T3133 610-619 NN denotes phenotype
T3134 620-622 IN denotes on
T3135 623-629 NN denotes Figure
T3136 630-632 NN denotes S1
T3137 632-633 -RRB- denotes )
T3138 635-638 DT denotes The
T3139 639-648 NN denotes CD4+CD25–
T3140 648-649 -COMMA- denotes ,
T3141 650-657 JJ denotes CD45RA+
T3142 657-658 -COMMA- denotes ,
T3143 659-666 JJ denotes CD45RO+
T3144 666-667 -COMMA- denotes ,
T3145 668-671 CC denotes and
T3146 672-688 NN denotes CD4+CD45RO+CD25–
T3147 689-693 VB denotes were
T3148 694-698 JJ denotes able
T3149 699-701 TO denotes to
T3150 702-715 RB denotes significantly
T3151 716-722 VB denotes induce
T3152 723-728 NN denotes FOXP3
T3153 729-733 NN denotes mRNA
T3154 734-736 IN denotes up
T3155 737-739 TO denotes to
T3156 740-747 RB denotes 30-fold
T3157 748-752 IN denotes upon
T3158 753-756 NN denotes TCR
T3159 757-767 NN denotes activation
T3160 768-771 CC denotes and
T3161 772-780 NN denotes addition
T3162 781-783 IN denotes of
T3163 784-789 NN denotes TGF-β
T3164 791-794 NN denotes Th1
T3165 795-800 NN denotes cells
T3166 801-807 VB denotes showed
T3167 808-812 RB denotes only
T3168 813-814 DT denotes a
T3169 815-822 JJ denotes 10-fold
T3170 823-831 NN denotes increase
T3171 833-835 IN denotes In
T3172 836-844 NN denotes contrast
T3173 844-845 -COMMA- denotes ,
T3174 846-849 NN denotes Th2
T3175 850-855 NN denotes cells
T3176 856-866 VB denotes stimulated
T3177 867-872 IN denotes under
T3178 873-876 DT denotes the
T3179 877-881 JJ denotes same
T3180 882-892 NN denotes conditions
T3181 893-896 VB denotes did
T3182 897-900 RB denotes not
T3183 901-909 VB denotes increase
T3184 910-915 NN denotes FOXP3
T3185 916-926 NN denotes expression
T3186 928-931 DT denotes The
T3187 932-934 FW denotes in
T3188 935-940 FW denotes vitro
T3189 941-950 VB denotes generated
T3190 951-956 NN denotes iTreg
T3191 957-962 NN denotes cells
T3192 963-967 VB denotes were
T3193 968-974 JJ denotes unable
T3194 975-977 TO denotes to
T3195 978-985 RB denotes further
T3196 986-997 VB denotes up-regulate
T3197 998-1003 NN denotes FOXP3
T3198 1003-1004 -COMMA- denotes ,
T3199 1005-1010 WDT denotes which
T3200 1011-1014 VB denotes was
T3201 1015-1022 RB denotes already
T3202 1023-1025 IN denotes at
T3203 1026-1030 JJ denotes high
T3204 1031-1037 NN denotes levels
T3205 1038-1043 IN denotes under
T3206 1044-1047 DT denotes the
T3207 1048-1055 JJ denotes resting
T3208 1056-1066 NN denotes conditions
T3209 1067-1068 -LRB- denotes (
T3210 1068-1074 NN denotes Figure
T3211 1075-1077 NN denotes 1B
T3212 1077-1078 -COMMA- denotes ,
T3213 1079-1084 JJ denotes right
T3214 1085-1090 NN denotes panel
T3215 1090-1091 -RRB- denotes )
T3216 1103-1106 NN denotes Th2
T3217 1107-1112 NN denotes Cells
T3218 1683-1686 VB denotes are
T3219 1687-1692 VB denotes known
T3220 1693-1695 TO denotes to
T3221 1696-1703 VB denotes produce
T3222 1704-1708 NN denotes IL-4
T3223 1709-1713 IN denotes upon
T3224 1714-1724 NN denotes activation
T3225 1724-1725 -COMMA- denotes ,
T3226 1726-1731 WDT denotes which
T3227 1732-1735 MD denotes may
T3228 1736-1744 VB denotes interact
T3229 1745-1749 IN denotes with
T3230 1750-1755 NN denotes TGF-β
T3231 1756-1765 NN denotes signaling
T3232 1766-1769 CC denotes and
T3233 1770-1774 RB denotes thus
T3234 1775-1782 VB denotes prevent
T3235 1783-1788 NN denotes FOXP3
T3236 1789-1798 NN denotes induction
T3237 1800-1807 RB denotes However
T3238 1807-1808 -COMMA- denotes ,
T3239 1809-1812 DT denotes the
T3240 1813-1827 NN denotes neutralization
T3241 1828-1830 IN denotes of
T3242 1831-1835 NN denotes IL-4
T3243 1836-1840 IN denotes with
T3244 1841-1842 DT denotes a
T3245 1843-1851 VB denotes blocking
T3246 1852-1856 NN denotes IL-4
T3247 1857-1865 NN denotes antibody
T3248 1866-1869 VB denotes did
T3249 1870-1873 RB denotes not
T3250 1874-1880 VB denotes rescue
T3251 1881-1886 NN denotes FOXP3
T3252 1887-1897 NN denotes expression
T3253 1898-1900 IN denotes in
T3254 1901-1904 DT denotes the
T3255 1905-1919 VB denotes differentiated
T3256 1920-1923 NN denotes Th2
T3257 1924-1929 NN denotes cells
T3258 1930-1931 -LRB- denotes (
T3259 1931-1942 JJ denotes unpublished
T3260 1943-1947 NN denotes data
T3261 1947-1948 -RRB- denotes )
T3262 1950-1955 DT denotes These
T3263 1956-1960 NN denotes data
T3264 1961-1973 VB denotes demonstrated
T3265 1974-1978 IN denotes that
T3266 1979-1982 NN denotes Th2
T3267 1983-1988 NN denotes cells
T3268 1989-1993 VB denotes have
T3269 1994-1995 DT denotes a
T3270 1996-2003 VB denotes limited
T3271 2004-2012 NN denotes capacity
T3272 2013-2015 TO denotes to
T3273 2016-2023 VB denotes express
T3274 2024-2029 NN denotes FOXP3
T3275 2030-2031 -LRB- denotes (
T3276 2031-2037 NN denotes Figure
T3277 2038-2040 NN denotes 1B
T3278 2040-2041 -RRB- denotes )
T3279 2043-2046 DT denotes The
T3280 2047-2056 NN denotes inability
T3281 2057-2059 IN denotes of
T3282 2060-2063 NN denotes Th2
T3283 2064-2069 NN denotes cells
T3284 2070-2072 TO denotes to
T3285 2073-2080 VB denotes express
T3286 2081-2086 NN denotes FOXP3
T3287 2087-2090 VB denotes was
T3288 2091-2095 RB denotes also
T3289 2096-2106 VB denotes documented
T3290 2107-2109 IN denotes at
T3291 2110-2113 DT denotes the
T3292 2114-2125 JJ denotes single-cell
T3293 2126-2131 NN denotes level
T3294 2131-2132 -COMMA- denotes ,
T3295 2133-2143 VB denotes confirming
T3296 2144-2148 IN denotes that
T3297 2149-2152 NN denotes Th2
T3298 2153-2158 NN denotes cells
T3299 2159-2163 VB denotes lack
T3300 2164-2169 NN denotes FOXP3
T3301 2170-2180 NN denotes expression
T3302 2181-2182 -LRB- denotes (
T3303 2182-2188 NN denotes Figure
T3304 2189-2191 NN denotes 2A
T3305 2191-2192 -RRB- denotes )
T3306 2194-2198 RB denotes Only
T3307 2199-2204 NN denotes iTreg
T3308 2205-2210 NN denotes cells
T3309 2211-2220 VB denotes expressed
T3310 2221-2226 NN denotes FOXP3
T3311 2227-2229 IN denotes in
T3312 2230-2237 VB denotes resting
T3313 2238-2248 NN denotes conditions
T3314 2250-2263 RB denotes Interestingly
T3315 2263-2264 -COMMA- denotes ,
T3316 2265-2267 PRP denotes we
T3317 2268-2276 VB denotes observed
T3318 2277-2281 IN denotes that
T3319 2282-2289 VB denotes resting
T3320 2290-2295 NN denotes iTreg
T3321 2296-2301 NN denotes cells
T3322 2302-2309 VB denotes express
T3323 2310-2315 NN denotes FOXP3
T3324 2316-2319 CC denotes but
T3325 2320-2324 VB denotes show
T3326 2325-2328 JJ denotes low
T3327 2329-2333 NN denotes CD25
T3328 2334-2341 NN denotes surface
T3329 2342-2352 NN denotes expression
T3330 2354-2362 VB denotes Repeated
T3331 2363-2371 NN denotes exposure
T3332 2372-2374 TO denotes to
T3333 2375-2380 NN denotes TGF-β
T3334 2381-2384 VB denotes did
T3335 2385-2388 RB denotes not
T3336 2389-2396 RB denotes further
T3337 2397-2405 VB denotes increase
T3338 2406-2409 DT denotes the
T3339 2410-2415 NN denotes FOXP3
T3340 2416-2426 NN denotes expression
T3341 2427-2429 IN denotes in
T3342 2430-2433 DT denotes the
T3343 2434-2439 NN denotes iTreg
T3344 2440-2447 NN denotes lineage
T3345 2448-2451 CC denotes but
T3346 2452-2463 RB denotes transiently
T3347 2464-2471 VB denotes induced
T3348 2472-2477 NN denotes FOXP3
T3349 2478-2488 NN denotes expression
T3350 2489-2491 IN denotes in
T3351 2492-2495 NN denotes Th1
T3352 2496-2501 NN denotes cells
T3353 2503-2512 RB denotes Naturally
T3354 2513-2522 VB denotes occurring
T3355 2523-2526 NN denotes Th2
T3356 2527-2532 NN denotes cells
T3357 2533-2537 JJ denotes such
T3358 2538-2540 IN denotes as
T3359 2541-2547 JJ denotes CRTH2+
T3360 2548-2549 NN denotes T
T3361 2550-2555 NN denotes cells
T3362 2555-2556 -COMMA- denotes ,
T3363 2557-2558 NN denotes T
T3364 2559-2564 NN denotes cells
T3365 2565-2573 VB denotes isolated
T3366 2574-2583 VB denotes according
T3367 2584-2586 TO denotes to
T3368 2587-2592 PRP-DOLLAR- denotes their
T3369 2593-2597 NN denotes IL-4
T3370 2598-2607 NN denotes secretion
T3371 2607-2608 -COMMA- denotes ,
T3372 2609-2611 CC denotes or
T3373 2612-2614 DT denotes an
T3374 2615-2629 JJ denotes IL-4–producing
T3375 2630-2631 NN denotes T
T3376 2632-2636 NN denotes cell
T3377 2637-2642 NN denotes clone
T3378 2643-2644 -LRB- denotes (
T3379 2644-2647 NN denotes BR8
T3380 2647-2648 -RRB- denotes )
T3381 2649-2653 VB denotes were
T3382 2654-2658 RB denotes also
T3383 2659-2666 VB denotes lacking
T3384 2667-2672 NN denotes FOXP3
T3385 2673-2683 NN denotes expression
T3386 2684-2685 -LRB- denotes (
T3387 2685-2691 NN denotes Figure
T3388 2692-2694 NN denotes 2B
T3389 2694-2695 -RRB- denotes )
T3390 2697-2708 RB denotes Furthermore
T3391 2709-2723 JJ denotes TGF-β–mediated
T3392 2724-2729 NN denotes FOXP3
T3393 2730-2739 NN denotes induction
T3394 2740-2746 VB denotes failed
T3395 2747-2749 IN denotes in
T3396 2750-2755 DT denotes these
T3397 2756-2761 NN denotes cells
T3398 2762-2764 IN denotes in
T3399 2765-2773 NN denotes contrast
T3400 2774-2776 TO denotes to
T3401 2777-2780 DT denotes the
T3402 2781-2786 JJ denotes naive
T3403 2787-2788 NN denotes T
T3404 2789-2794 NN denotes cells
T3405 2795-2796 -LRB- denotes (
T3406 2796-2802 NN denotes Figure
T3407 2803-2805 NN denotes 2B
T3408 2805-2806 -RRB- denotes )
T3409 2808-2815 IN denotes Because
T3410 2816-2820 NN denotes IL-4
T3411 2821-2823 VB denotes is
T3412 2824-2827 DT denotes the
T3413 2828-2831 JJ denotes key
T3414 2832-2835 NN denotes Th2
T3415 2836-2844 NN denotes cytokine
T3416 2844-2845 -COMMA- denotes ,
T3417 2846-2849 DT denotes the
T3418 2850-2860 NN denotes expression
T3419 2861-2863 IN denotes of
T3420 2864-2868 NN denotes IL-4
T3421 2869-2872 CC denotes and
T3422 2873-2878 NN denotes FOXP3
T3423 2879-2881 IN denotes in
T3424 2882-2889 RB denotes freshly
T3425 2890-2898 VB denotes isolated
T3426 2899-2903 JJ denotes CD4+
T3427 2904-2905 NN denotes T
T3428 2906-2911 NN denotes cells
T3429 2912-2915 VB denotes was
T3430 2916-2924 VB denotes analyzed
T3431 2925-2927 IN denotes by
T3432 2928-2940 NN denotes fluorescence
T3433 2941-2950 VB denotes activated
T3434 2951-2955 NN denotes cell
T3435 2956-2963 NN denotes sorting
T3436 2964-2965 -LRB- denotes (
T3437 2965-2969 NN denotes FACS
T3438 2969-2970 -RRB- denotes )
T3439 2972-2987 JJ denotes IL-4–expressing
T3440 2988-2993 NN denotes cells
T3441 2994-2998 VB denotes were
T3442 2999-3003 RB denotes most
T3443 3004-3012 JJ denotes abundant
T3444 3013-3018 IN denotes among
T3445 3019-3031 NN denotes CD45RO+CD25–
T3446 3032-3037 NN denotes cells
T3447 3037-3038 -COMMA- denotes ,
T3448 3039-3044 WDT denotes which
T3449 3045-3048 VB denotes did
T3450 3049-3052 RB denotes not
T3451 3053-3063 VB denotes co-express
T3452 3064-3069 NN denotes FOXP3
T3453 3070-3071 -LRB- denotes (
T3454 3071-3077 NN denotes Figure
T3455 3078-3080 NN denotes 3A
T3456 3080-3081 -COMMA- denotes ,
T3457 3082-3086 JJ denotes left
T3458 3087-3092 NN denotes panel
T3459 3092-3093 -RRB- denotes )
T3460 3095-3097 IN denotes In
T3461 3098-3106 NN denotes contrast
T3462 3106-3107 -COMMA- denotes ,
T3463 3108-3120 JJ denotes CD45RO+CD25+
T3464 3121-3126 NN denotes cells
T3465 3127-3137 RB denotes abundantly
T3466 3138-3147 VB denotes expressed
T3467 3148-3153 NN denotes FOXP3
T3468 3153-3154 -COMMA- denotes ,
T3469 3155-3160 IN denotes while
T3470 3161-3168 VB denotes lacking
T3471 3169-3173 NN denotes IL-4
T3472 3174-3175 -LRB- denotes (
T3473 3175-3181 NN denotes Figure
T3474 3182-3184 NN denotes 3A
T3475 3184-3185 -COMMA- denotes ,
T3476 3186-3191 JJ denotes right
T3477 3192-3197 NN denotes panel
T3478 3197-3198 -RRB- denotes )
T3479 3200-3202 IN denotes As
T3480 3203-3208 VB denotes shown
T3481 3209-3211 IN denotes in
T3482 3212-3218 NN denotes Figure
T3483 3219-3221 NN denotes 3B
T3484 3221-3222 -COMMA- denotes ,
T3485 3223-3226 DT denotes the
T3486 3227-3236 NN denotes frequency
T3487 3237-3239 IN denotes of
T3488 3240-3243 DT denotes the
T3489 3244-3249 JJ denotes IL-4+
T3490 3250-3255 NN denotes cells
T3491 3256-3259 VB denotes was
T3492 3260-3266 RB denotes always
T3493 3267-3272 IN denotes below
T3494 3273-3274 CD denotes 1
T3495 3274-3275 NN denotes %
T3496 3276-3278 IN denotes in
T3497 3279-3282 DT denotes the
T3498 3283-3289 JJ denotes FOXP3+
T3499 3290-3295 NN denotes cells
T3500 3296-3301 RB denotes close
T3501 3302-3304 TO denotes to
T3502 3305-3308 DT denotes the
T3503 3309-3319 NN denotes background
T3504 3321-3324 DT denotes The
T3505 3325-3330 JJ denotes IL-4+
T3506 3331-3336 NN denotes cells
T3507 3337-3341 VB denotes were
T3508 3342-3350 VB denotes confined
T3509 3351-3353 TO denotes to
T3510 3354-3357 DT denotes the
T3511 3358-3364 NN denotes FOXP3–
T3512 3365-3370 NN denotes cells
T3513 3370-3371 -COMMA- denotes ,
T3514 3372-3374 IN denotes as
T3515 3375-3380 VB denotes shown
T3516 3381-3384 IN denotes for
T3517 3385-3388 DT denotes the
T3518 3389-3401 NN denotes CD45RO+CD25–
T3519 3401-3402 -COMMA- denotes ,
T3520 3403-3415 JJ denotes CD45RO+CD25+
T3521 3415-3416 -COMMA- denotes ,
T3522 3417-3420 CC denotes and
T3523 3421-3437 JJ denotes CD45RO+CD25+high
T3524 3438-3443 NN denotes cells
T3525 3444-3445 -LRB- denotes (
T3526 3445-3451 NN denotes Figure
T3527 3452-3454 NN denotes 3B
T3528 3454-3455 -RRB- denotes )
T3529 3457-3459 IN denotes In
T3530 3460-3468 NN denotes addition
T3531 3468-3469 -COMMA- denotes ,
T3532 3470-3477 CC denotes neither
T3533 3478-3481 DT denotes the
T3534 3482-3485 NN denotes Th2
T3535 3486-3491 NN denotes clone
T3536 3492-3493 -LRB- denotes (
T3537 3493-3496 NN denotes BR8
T3538 3496-3497 -RRB- denotes )
T3539 3498-3501 CC denotes nor
T3540 3502-3507 NN denotes CRTH2
T3541 3508-3513 NN denotes cells
T3542 3514-3527 RB denotes significantly
T3543 3528-3537 VB denotes expressed
T3544 3538-3543 NN denotes FOXP3
T3545 3544-3545 -LRB- denotes (
T3546 3545-3551 NN denotes Figure
T3547 3552-3554 NN denotes 3C
T3548 3554-3555 -RRB- denotes )
T3549 3557-3562 NN denotes Cells
T3550 3563-3571 VB denotes enriched
T3551 3572-3575 IN denotes for
T3552 3576-3581 PRP-DOLLAR- denotes their
T3553 3582-3586 NN denotes IL-4
T3554 3587-3596 NN denotes secretion
T3555 3597-3602 VB denotes using
T3556 3603-3606 DT denotes the
T3557 3607-3615 JJ denotes magnetic
T3558 3616-3620 NN denotes cell
T3559 3621-3630 NN denotes isolation
T3560 3631-3641 NN denotes technology
T3561 3642-3651 VB denotes contained
T3562 3652-3656 DT denotes some
T3563 3657-3673 JJ denotes FOXP3-expressing
T3564 3674-3679 NN denotes cells
T3565 3679-3680 -COMMA- denotes ,
T3566 3681-3684 CC denotes but
T3567 3685-3696 RB denotes importantly
T3568 3696-3697 -COMMA- denotes ,
T3569 3698-3701 DT denotes the
T3570 3702-3712 NN denotes expression
T3571 3713-3716 VB denotes did
T3572 3717-3720 RB denotes not
T3573 3721-3728 VB denotes overlap
T3574 3730-3735 VB denotes Taken
T3575 3736-3744 RB denotes together
T3576 3744-3745 -COMMA- denotes ,
T3577 3746-3751 DT denotes these
T3578 3752-3756 NN denotes data
T3579 3757-3765 VB denotes indicate
T3580 3766-3770 IN denotes that
T3581 3771-3776 NN denotes FOXP3
T3582 3777-3780 VB denotes was
T3583 3781-3784 RB denotes not
T3584 3785-3794 VB denotes expressed
T3585 3795-3797 IN denotes by
T3586 3798-3801 NN denotes Th2
T3587 3802-3807 NN denotes cells
T3588 3808-3811 CC denotes and
T3589 3812-3815 VB denotes was
T3590 3816-3819 RB denotes not
T3591 3820-3829 JJ denotes inducible
T3592 3830-3832 IN denotes in
T3593 3833-3838 DT denotes those
T3594 3839-3844 NN denotes cells
T23464 1103-1106 NN denotes Th2
T23465 1107-1112 NN denotes Cells
T23466 1113-1116 MD denotes Can
T23467 1116-1119 RB denotes not
T23468 1120-1126 VB denotes Induce
T23469 1127-1132 NN denotes FOXP3
T23470 1133-1143 NN denotes Expression
T23471 1144-1145 -LRB- denotes (
T23472 1145-1146 NN denotes A
T23473 1146-1147 -RRB- denotes )
T23474 1148-1153 JJ denotes Human
T23475 1154-1155 NN denotes T
T23476 1156-1161 NN denotes cells
T23477 1162-1166 VB denotes were
T23478 1167-1176 VB denotes activated
T23479 1177-1181 IN denotes with
T23480 1182-1193 JJ denotes plate-bound
T23481 1194-1207 NN denotes anti-CD3/CD28
T23482 1208-1212 IN denotes with
T23483 1213-1215 CC denotes or
T23484 1216-1223 IN denotes without
T23485 1224-1229 NN denotes TGF-β
T23486 1230-1232 IN denotes as
T23487 1233-1242 VB denotes indicated
T23488 1243-1245 IN denotes on
T23489 1246-1249 DT denotes the
T23490 1250-1256 NN denotes x-axis
T23491 1257-1259 IN denotes of
T23492 1260-1261 -LRB- denotes (
T23493 1261-1262 NN denotes B
T23494 1262-1263 -RRB- denotes )
T23495 1265-1270 NN denotes Cells
T23496 1271-1275 VB denotes were
T23497 1276-1285 VB denotes harvested
T23498 1286-1291 IN denotes after
T23499 1292-1293 CD denotes 5
T23500 1294-1298 NN denotes days
T23501 1299-1302 CC denotes and
T23502 1303-1308 NN denotes FOXP3
T23503 1309-1313 NN denotes mRNA
T23504 1314-1317 VB denotes was
T23505 1318-1328 VB denotes quantified
T23506 1329-1331 IN denotes by
T23507 1332-1341 JJ denotes real-time
T23508 1342-1345 NN denotes PCR
T23509 1347-1351 NN denotes Bars
T23510 1352-1356 VB denotes show
T23511 1357-1360 DT denotes the
T23512 1361-1365 JJ denotes mean
T23513 1366-1367 JJ denotes ±
T23514 1368-1370 NN denotes SD
T23515 1371-1373 IN denotes of
T23516 1374-1375 CD denotes 4
T23517 1376-1387 JJ denotes independent
T23518 1388-1399 NN denotes experiments
T23519 1401-1402 -LRB- denotes (
T23520 1402-1403 NN denotes B
T23521 1403-1404 -RRB- denotes )
T23522 1405-1407 FW denotes In
T23523 1408-1413 FW denotes vitro
T23524 1414-1428 VB denotes differentiated
T23525 1429-1432 NN denotes Th1
T23526 1432-1433 -COMMA- denotes ,
T23527 1434-1437 NN denotes Th2
T23528 1437-1438 -COMMA- denotes ,
T23529 1439-1441 CC denotes or
T23530 1442-1447 NN denotes iTreg
T23531 1448-1453 NN denotes cells
T23532 1454-1458 VB denotes were
T23533 1459-1468 VB denotes activated
T23534 1469-1473 IN denotes with
T23535 1474-1487 JJ denotes anti-CD3/CD28
T23536 1487-1488 -COMMA- denotes ,
T23537 1489-1494 NN denotes TGF-β
T23538 1494-1495 -COMMA- denotes ,
T23539 1496-1498 CC denotes or
T23540 1499-1508 NN denotes anti-IL-4
T23541 1509-1511 IN denotes as
T23542 1512-1521 VB denotes indicated
T23543 1523-1526 DT denotes The
T23544 1527-1536 NN denotes phenotype
T23545 1537-1539 IN denotes of
T23546 1540-1545 DT denotes these
T23547 1546-1551 NN denotes cells
T23548 1552-1555 VB denotes was
T23549 1556-1565 VB denotes confirmed
T23550 1566-1568 IN denotes by
T23551 1569-1573 NN denotes FACS
T23552 1574-1577 CC denotes and
T23553 1578-1591 NN denotes proliferation
T23554 1592-1600 NN denotes analysis
T23555 1601-1602 -LRB- denotes (
T23556 1602-1608 NN denotes Figure
T23557 1609-1611 NN denotes S1
T23558 1611-1612 -RRB- denotes )
T23559 1614-1618 NN denotes Bars
T23560 1619-1623 VB denotes show
T23561 1624-1627 DT denotes the
T23562 1628-1632 JJ denotes mean
T23563 1633-1634 JJ denotes ±
T23564 1635-1637 NN denotes SD
T23565 1638-1640 IN denotes of
T23566 1641-1645 CD denotes four
T23567 1646-1657 JJ denotes independent
T23568 1658-1669 NN denotes experiments
T23815 3856-3859 NN denotes Th2
T23816 3860-3865 NN denotes Cells
T23817 3866-3868 VB denotes Do
T23818 3869-3872 NNP denotes Not
T23819 3873-3880 NNP denotes Express
T23820 3881-3886 NN denotes FOXP3
T23821 3887-3888 -LRB- denotes (
T23822 3888-3889 NN denotes A
T23823 3889-3890 -RRB- denotes )
T23824 3891-3904 JJ denotes Intracellular
T23825 3905-3909 NN denotes FACS
T23826 3910-3918 NN denotes analysis
T23827 3919-3921 IN denotes of
T23828 3922-3927 NN denotes FOXP3
T23829 3928-3938 NN denotes expression
T23830 3939-3941 IN denotes in
T23831 3942-3945 NN denotes Th1
T23832 3945-3946 -COMMA- denotes ,
T23833 3947-3950 NN denotes Th2
T23834 3950-3951 -COMMA- denotes ,
T23835 3952-3954 CC denotes or
T23836 3955-3975 JJ denotes iTreg-differentiated
T23837 3976-3981 NN denotes cells
T23838 3982-3983 -LRB- denotes (
T23839 3983-3986 CD denotes two
T23840 3987-3993 NN denotes rounds
T23841 3993-3994 -COMMA- denotes ,
T23842 3995-4004 NN denotes phenotype
T23843 4005-4008 VB denotes see
T23844 4009-4015 NN denotes Figure
T23845 4016-4018 NN denotes S1
T23846 4018-4019 -RRB- denotes )
T23847 4019-4020 -COMMA- denotes ,
T23848 4021-4027 VB denotes rested
T23849 4028-4030 CC denotes or
T23850 4031-4040 VB denotes activated
T23851 4040-4041 -COMMA- denotes ,
T23852 4042-4046 IN denotes with
T23853 4047-4049 CC denotes or
T23854 4050-4057 IN denotes without
T23855 4058-4063 NN denotes TGF-β
T23856 4065-4070 NN denotes FOXP3
T23857 4071-4081 NN denotes expression
T23858 4082-4085 VB denotes was
T23859 4086-4094 VB denotes measured
T23860 4095-4100 IN denotes after
T23861 4101-4102 CD denotes 5
T23862 4103-4104 NN denotes d
T23863 4105-4107 IN denotes in
T23864 4108-4115 NN denotes culture
T23865 4117-4120 DT denotes The
T23866 4121-4124 NN denotes dot
T23867 4125-4130 NN denotes blots
T23868 4131-4134 VB denotes are
T23869 4135-4149 JJ denotes representative
T23870 4150-4152 IN denotes of
T23871 4153-4158 CD denotes three
T23872 4159-4170 JJ denotes independent
T23873 4171-4182 NN denotes experiments
T23874 4184-4185 -LRB- denotes (
T23875 4185-4186 NN denotes B
T23876 4186-4187 -RRB- denotes )
T23877 4188-4193 VB denotes Shows
T23878 4194-4197 DT denotes the
T23879 4198-4202 JJ denotes same
T23880 4203-4215 JJ denotes experimental
T23881 4216-4221 NN denotes setup
T23882 4221-4222 -COMMA- denotes ,
T23883 4223-4226 CC denotes but
T23884 4227-4236 RB denotes naturally
T23885 4237-4246 VB denotes occurring
T23886 4247-4250 NN denotes Th2
T23887 4251-4256 NN denotes cells
T23888 4257-4261 VB denotes were
T23889 4262-4270 VB denotes analyzed
T23890 4272-4276 NN denotes Data
T23891 4277-4280 VB denotes are
T23892 4281-4295 JJ denotes representative
T23893 4296-4298 IN denotes of
T23894 4299-4304 CD denotes three
T23895 4305-4316 JJ denotes independent
T23896 4317-4328 NN denotes experiments
T24133 4340-4344 NN denotes Th2-
T24134 4345-4347 CC denotes or
T24135 4348-4362 JJ denotes IL-4–Producing
T24136 4363-4368 NNP denotes Cells
T24137 4369-4373 NN denotes Lack
T24138 4374-4379 NN denotes FOXP3
T24139 4380-4381 -LRB- denotes (
T24140 4381-4382 NN denotes A
T24141 4382-4383 -RRB- denotes )
T24142 4384-4388 NN denotes FACS
T24143 4389-4397 NN denotes analysis
T24144 4398-4400 IN denotes of
T24145 4401-4414 JJ denotes intracellular
T24146 4415-4420 NN denotes FOXP3
T24147 4421-4424 CC denotes and
T24148 4425-4429 NN denotes IL-4
T24149 4430-4440 NN denotes expression
T24150 4441-4450 VB denotes following
T24151 4451-4464 NN denotes PMA/Ionomycin
T24152 4465-4476 NN denotes stimulation
T24153 4478-4482 JJ denotes CD4+
T24154 4483-4484 NN denotes T
T24155 4485-4490 NN denotes cells
T24156 4491-4495 VB denotes were
T24157 4496-4501 VB denotes gated
T24158 4502-4504 IN denotes on
T24159 4505-4508 DT denotes the
T24160 4509-4514 NN denotes basis
T24161 4515-4517 IN denotes of
T24162 4518-4524 NN denotes CD45RO
T24163 4525-4528 CC denotes and
T24164 4529-4533 NN denotes CD25
T24165 4534-4541 NN denotes surface
T24166 4542-4552 NN denotes expression
T24167 4553-4554 -LRB- denotes (
T24168 4554-4559 JJ denotes upper
T24169 4560-4565 NN denotes panel
T24170 4565-4566 -RRB- denotes )
T24171 4566-4567 -COMMA- denotes ,
T24172 4568-4571 CC denotes and
T24173 4572-4577 VB denotes gated
T24174 4578-4583 NN denotes cells
T24175 4584-4587 VB denotes are
T24176 4588-4593 VB denotes shown
T24177 4594-4599 IN denotes below
T24178 4600-4603 IN denotes for
T24179 4604-4607 DT denotes the
T24180 4608-4620 NN denotes CD45RO+CD25−
T24181 4621-4622 -LRB- denotes (
T24182 4622-4623 NN denotes A
T24183 4623-4624 -COMMA- denotes ,
T24184 4625-4629 JJ denotes left
T24185 4630-4635 NN denotes panel
T24186 4635-4636 -RRB- denotes )
T24187 4636-4637 -COMMA- denotes ,
T24188 4638-4641 DT denotes the
T24189 4642-4654 JJ denotes CD45RO+CD25+
T24190 4655-4656 -LRB- denotes (
T24191 4656-4661 JJ denotes right
T24192 4662-4667 NN denotes panel
T24193 4667-4668 -RRB- denotes )
T24194 4668-4669 -COMMA- denotes ,
T24195 4670-4673 CC denotes and
T24196 4674-4677 DT denotes the
T24197 4678-4690 NN denotes CD45RO−CD25−
T24198 4691-4698 NN denotes subsets
T24199 4699-4700 -LRB- denotes (
T24200 4700-4707 JJ denotes central
T24201 4708-4713 NN denotes panel
T24202 4713-4714 -RRB- denotes )
T24203 4716-4717 DT denotes A
T24204 4718-4729 JJ denotes statistical
T24205 4730-4738 NN denotes analysis
T24206 4739-4741 IN denotes of
T24207 4742-4747 CD denotes eight
T24208 4748-4759 JJ denotes independent
T24209 4760-4766 NN denotes donors
T24210 4767-4772 IN denotes after
T24211 4773-4784 NN denotes subtraction
T24212 4785-4787 IN denotes of
T24213 4788-4791 DT denotes the
T24214 4792-4799 NN denotes isotype
T24215 4800-4807 NN denotes control
T24216 4808-4811 VB denotes are
T24217 4812-4817 VB denotes shown
T24218 4818-4820 IN denotes in
T24219 4821-4822 -LRB- denotes (
T24220 4822-4823 NN denotes B
T24221 4823-4824 -RRB- denotes )
T24222 4826-4829 DT denotes The
T24223 4830-4836 VB denotes dotted
T24224 4837-4841 JJ denotes gray
T24225 4842-4846 NN denotes line
T24226 4847-4856 VB denotes indicates
T24227 4857-4860 DT denotes the
T24228 4861-4863 NN denotes IC
T24229 4864-4874 NN denotes background
T24230 4875-4880 NN denotes level
T24231 4882-4885 DT denotes The
T24232 4886-4891 NN denotes error
T24233 4892-4896 NN denotes bars
T24234 4897-4901 VB denotes show
T24235 4902-4905 DT denotes the
T24236 4906-4911 NN denotes error
T24237 4912-4914 IN denotes of
T24238 4915-4918 DT denotes the
T24239 4919-4924 NN denotes mean.
T24240 4925-4926 -LRB- denotes (
T24241 4926-4927 NN denotes C
T24242 4927-4928 -RRB- denotes )
T24243 4929-4938 RB denotes Similarly
T24244 4938-4939 -COMMA- denotes ,
T24245 4940-4941 DT denotes a
T24246 4942-4945 NN denotes Th2
T24247 4946-4951 NN denotes clone
T24248 4952-4953 -LRB- denotes (
T24249 4953-4956 NN denotes BR8
T24250 4956-4957 -RRB- denotes )
T24251 4957-4958 -COMMA- denotes ,
T24252 4959-4965 JJ denotes CRTH2+
T24253 4966-4969 NN denotes Th2
T24254 4970-4975 NN denotes cells
T24255 4975-4976 -COMMA- denotes ,
T24256 4977-4991 NN denotes IL-4-secreting
T24257 4992-4997 NN denotes cells
T24258 4997-4998 -COMMA- denotes ,
T24259 4999-5002 CC denotes and
T24260 5003-5009 NN denotes memory
T24261 5010-5011 NN denotes T
T24262 5012-5017 NN denotes cells
T24263 5018-5019 -LRB- denotes (
T24264 5019-5025 NN denotes CD45RO
T24265 5025-5026 -RRB- denotes )
T24266 5027-5031 VB denotes were
T24267 5032-5039 VB denotes stained
T24268 5040-5043 IN denotes for
T24269 5044-5049 NN denotes FOXP3
T24270 5050-5053 CC denotes and
T24271 5054-5058 NN denotes IL-4
T24272 5060-5064 NN denotes Data
T24273 5065-5068 VB denotes are
T24274 5069-5083 JJ denotes representative
T24275 5084-5086 IN denotes of
T24276 5087-5092 CD denotes three
T24277 5093-5104 JJ denotes independent
T24278 5105-5116 NN denotes experiments
R2365 T3017 T3016 arg1Of Induction,FOXP3
R2366 T3017 T3018 arg1Of Induction,in
R2367 T3021 T3018 arg2Of Subsets,in
R2368 T3021 T3019 arg1Of Subsets,T
R2369 T3021 T3020 arg1Of Subsets,Cell
R2370 T3022 T3023 arg1Of It,is
R2371 T3022 T3024 arg2Of It,assumed
R2372 T3024 T3023 arg2Of assumed,is
R2373 T3027 T3026 arg1Of expression,FOXP3
R2374 T3027 T3028 arg1Of expression,can
R2375 T3027 T3029 arg1Of expression,be
R2376 T3027 T3030 arg2Of expression,induced
R2377 T3030 T3024 arg3Of induced,assumed
R2378 T3030 T3025 arg1Of induced,that
R2379 T3030 T3028 arg2Of induced,can
R2380 T3030 T3029 arg2Of induced,be
R2381 T3030 T3031 arg1Of induced,in
R2382 T3034 T3031 arg2Of cells,in
R2383 T3034 T3032 arg1Of cells,nonregulatory
R2384 T3034 T3033 arg1Of cells,T
R2385 T3034 T3035 arg1Of cells,","
R2386 T3034 T3036 arg1Of cells,which
R2387 T3034 T3037 arg1Of cells,is
R2388 T3040 T3037 arg2Of step,is
R2389 T3040 T3038 arg1Of step,an
R2390 T3040 T3039 arg1Of step,important
R2391 T3040 T3041 arg1Of step,in
R2392 T3044 T3041 arg2Of differentiation,in
R2393 T3044 T3042 arg1Of differentiation,iTreg
R2394 T3044 T3043 arg1Of differentiation,cell
R2395 T3047 T3048 arg1Of it,is
R2396 T3047 T3050 arg2Of it,known
R2397 T3050 T3045 arg1Of known,However
R2398 T3050 T3046 arg1Of known,","
R2399 T3050 T3048 arg2Of known,is
R2400 T3050 T3049 arg1Of known,not
R2401 T3050 T3051 arg1Of known,if
R2402 T3055 T3052 arg1Of cells,all
R2403 T3055 T3053 arg1Of cells,CD4+
R2404 T3055 T3054 arg1Of cells,T
R2405 T3055 T3056 arg1Of cells,have
R2406 T3056 T3051 arg2Of have,if
R2407 T3059 T3056 arg2Of capacity,have
R2408 T3059 T3057 arg1Of capacity,the
R2409 T3059 T3058 arg1Of capacity,same
R2410 T3059 T3060 modOf capacity,to
R2411 T3061 T3060 arg1Of express,to
R2412 T3062 T3061 arg2Of FOXP3,express
R2413 T3064 T3063 arg1Of investigate,To
R2414 T3066 T3067 arg1Of FOXP3,can
R2415 T3066 T3068 arg1Of FOXP3,be
R2416 T3066 T3069 arg2Of FOXP3,expressed
R2417 T3069 T3064 arg2Of expressed,investigate
R2418 T3069 T3065 arg1Of expressed,whether
R2419 T3069 T3067 arg2Of expressed,can
R2420 T3069 T3068 arg2Of expressed,be
R2421 T3069 T3070 arg1Of expressed,by
R2422 T3069 T3076 arg1Of expressed,if
R2423 T3070 T3075 arg1Of by,or
R2424 T3074 T3070 arg2Of subset,by
R2425 T3074 T3071 arg1Of subset,any
R2426 T3074 T3072 arg1Of subset,T
R2427 T3074 T3073 arg1Of subset,cell
R2428 T3076 T3075 arg2Of if,or
R2429 T3077 T3078 arg1Of expression,is
R2430 T3077 T3079 arg1Of expression,restricted
R2431 T3078 T3076 arg2Of is,if
R2432 T3079 T3078 arg2Of restricted,is
R2433 T3079 T3080 arg1Of restricted,to
R2434 T3083 T3080 arg2Of lineage,to
R2435 T3083 T3081 arg1Of lineage,a
R2436 T3083 T3082 arg1Of lineage,distinct
R2437 T3087 T3064 arg1Of expression,investigate
R2438 T3087 T3085 arg1Of expression,FOXP3
R2439 T3087 T3086 arg1Of expression,mRNA
R2440 T3087 T3088 arg1Of expression,was
R2441 T3087 T3089 arg2Of expression,analyzed
R2442 T3089 T3063 modOf analyzed,To
R2443 T3089 T3084 arg1Of analyzed,","
R2444 T3089 T3088 arg2Of analyzed,was
R2445 T3089 T3090 arg1Of analyzed,in
R2446 T3094 T3091 arg1Of cells,freshly
R2447 T3094 T3092 arg2Of cells,isolated
R2448 T3094 T3093 arg1Of cells,T
R2449 T3094 T3096 arg1Of cells,as
R2450 T3094 T3100 arg1Of cells,","
R2451 T3096 T3095 arg1Of as,such
R2452 T3099 T3096 arg2Of cells,as
R2453 T3099 T3097 arg1Of cells,CD25-depleted
R2454 T3099 T3098 arg1Of cells,CD4+
R2455 T3100 T3115 arg1Of ",",as
R2456 T3102 T3103 arg1Of naive,or
R2457 T3104 T3103 arg2Of CD45RO+,or
R2458 T3107 T3100 arg2Of cells,","
R2459 T3107 T3101 arg1Of cells,CD45RA+
R2460 T3107 T3102 arg1Of cells,naive
R2461 T3107 T3104 arg1Of cells,CD45RO+
R2462 T3107 T3105 arg1Of cells,memory
R2463 T3107 T3106 arg1Of cells,T
R2464 T3107 T3108 arg1Of cells,(
R2465 T3110 T3108 arg2Of 1A,(
R2466 T3110 T3109 arg1Of 1A,Figure
R2467 T3111 T3108 arg3Of ),(
R2468 T3115 T3090 arg2Of as,in
R2469 T3115 T3112 arg1Of as,","
R2470 T3115 T3113 arg1Of as,as
R2471 T3115 T3114 arg1Of as,well
R2472 T3117 T3115 arg2Of cells,as
R2473 T3117 T3116 arg1Of cells,T
R2474 T3117 T3118 arg2Of cells,driven
R2475 T3118 T3120 arg1Of driven,vitro
R2476 T3118 T3121 arg1Of driven,toward
R2477 T3120 T3119 arg1Of vitro,in
R2478 T3122 T3123 arg1Of Th1,","
R2479 T3123 T3126 arg1Of ",",or
R2480 T3124 T3123 arg2Of Th2,","
R2481 T3126 T3125 arg1Of or,","
R2482 T3127 T3126 arg2Of iTreg,or
R2483 T3128 T3121 arg2Of phenotypes,toward
R2484 T3128 T3122 arg1Of phenotypes,Th1
R2485 T3128 T3124 arg1Of phenotypes,Th2
R2486 T3128 T3127 arg1Of phenotypes,iTreg
R2487 T3128 T3129 arg1Of phenotypes,(
R2488 T3131 T3130 arg1Of 1B,Figure
R2489 T3131 T3132 arg1Of 1B,;
R2490 T3132 T3129 arg2Of ;,(
R2491 T3132 T3134 arg1Of ;,on
R2492 T3133 T3132 arg2Of phenotype,;
R2493 T3136 T3134 arg2Of S1,on
R2494 T3136 T3135 arg1Of S1,Figure
R2495 T3137 T3129 arg3Of ),(
R2496 T3139 T3138 arg1Of CD4+CD25–,The
R2497 T3139 T3140 arg1Of CD4+CD25–,","
R2498 T3139 T3142 arg1Of CD4+CD25–,","
R2499 T3141 T3140 arg2Of CD45RA+,","
R2500 T3142 T3145 arg1Of ",",and
R2501 T3143 T3142 arg2Of CD45RO+,","
R2502 T3145 T3144 arg1Of and,","
R2503 T3145 T3147 arg1Of and,were
R2504 T3145 T3148 arg1Of and,able
R2505 T3145 T3151 arg1Of and,induce
R2506 T3146 T3145 arg2Of CD4+CD45RO+CD25–,and
R2507 T3148 T3147 arg2Of able,were
R2508 T3151 T3148 arg2Of induce,able
R2509 T3151 T3149 arg1Of induce,to
R2510 T3151 T3150 arg1Of induce,significantly
R2511 T3151 T3157 arg1Of induce,upon
R2512 T3153 T3151 arg2Of mRNA,induce
R2513 T3153 T3152 arg1Of mRNA,FOXP3
R2514 T3154 T3155 arg1Of up,to
R2515 T3157 T3154 arg1Of upon,up
R2516 T3157 T3156 arg1Of upon,30-fold
R2517 T3159 T3158 arg1Of activation,TCR
R2518 T3159 T3160 arg1Of activation,and
R2519 T3160 T3157 arg2Of and,upon
R2520 T3161 T3160 arg2Of addition,and
R2521 T3161 T3162 arg1Of addition,of
R2522 T3163 T3162 arg2Of TGF-β,of
R2523 T3165 T3164 arg1Of cells,Th1
R2524 T3165 T3166 arg1Of cells,showed
R2525 T3170 T3166 arg2Of increase,showed
R2526 T3170 T3167 arg1Of increase,only
R2527 T3170 T3168 arg1Of increase,a
R2528 T3170 T3169 arg1Of increase,10-fold
R2529 T3172 T3171 arg2Of contrast,In
R2530 T3175 T3174 arg1Of cells,Th2
R2531 T3175 T3176 arg2Of cells,stimulated
R2532 T3175 T3181 arg1Of cells,did
R2533 T3175 T3183 arg1Of cells,increase
R2534 T3176 T3177 arg1Of stimulated,under
R2535 T3180 T3177 arg2Of conditions,under
R2536 T3180 T3178 arg1Of conditions,the
R2537 T3180 T3179 arg1Of conditions,same
R2538 T3183 T3171 arg1Of increase,In
R2539 T3183 T3173 arg1Of increase,","
R2540 T3183 T3181 arg2Of increase,did
R2541 T3183 T3182 arg1Of increase,not
R2542 T3185 T3183 arg2Of expression,increase
R2543 T3185 T3184 arg1Of expression,FOXP3
R2544 T3188 T3187 arg1Of vitro,in
R2545 T3189 T3188 arg1Of generated,vitro
R2546 T3191 T3186 arg1Of cells,The
R2547 T3191 T3189 arg1Of cells,generated
R2548 T3191 T3190 arg1Of cells,iTreg
R2549 T3191 T3192 arg1Of cells,were
R2550 T3191 T3193 arg1Of cells,unable
R2551 T3191 T3196 arg1Of cells,up-regulate
R2552 T3193 T3192 arg2Of unable,were
R2553 T3196 T3193 arg2Of up-regulate,unable
R2554 T3196 T3194 arg1Of up-regulate,to
R2555 T3196 T3195 arg1Of up-regulate,further
R2556 T3197 T3196 arg2Of FOXP3,up-regulate
R2557 T3197 T3198 arg1Of FOXP3,","
R2558 T3197 T3199 arg1Of FOXP3,which
R2559 T3197 T3200 arg1Of FOXP3,was
R2560 T3197 T3202 arg1Of FOXP3,at
R2561 T3200 T3201 arg1Of was,already
R2562 T3200 T3205 arg1Of was,under
R2563 T3202 T3200 arg2Of at,was
R2564 T3204 T3202 arg2Of levels,at
R2565 T3204 T3203 arg1Of levels,high
R2566 T3208 T3205 arg2Of conditions,under
R2567 T3208 T3206 arg1Of conditions,the
R2568 T3208 T3207 arg1Of conditions,resting
R2569 T3208 T3209 arg1Of conditions,(
R2570 T3211 T3209 arg2Of 1B,(
R2571 T3211 T3210 arg1Of 1B,Figure
R2572 T3211 T3212 arg1Of 1B,","
R2573 T3214 T3212 arg2Of panel,","
R2574 T3214 T3213 arg1Of panel,right
R2575 T3215 T3209 arg3Of ),(
R2576 T3217 T3216 arg1Of Cells,Th2
R2577 T3217 T3218 arg1Of Cells,are
R2578 T3217 T3219 arg2Of Cells,known
R2579 T3217 T3221 arg1Of Cells,produce
R2580 T3219 T3218 arg2Of known,are
R2581 T3221 T3219 arg3Of produce,known
R2582 T3221 T3220 arg1Of produce,to
R2583 T3221 T3223 arg1Of produce,upon
R2584 T3222 T3221 arg2Of IL-4,produce
R2585 T3224 T3223 arg2Of activation,upon
R2586 T3224 T3225 arg1Of activation,","
R2587 T3224 T3226 arg1Of activation,which
R2588 T3224 T3227 arg1Of activation,may
R2589 T3224 T3228 arg1Of activation,interact
R2590 T3224 T3234 arg1Of activation,prevent
R2591 T3228 T3227 arg2Of interact,may
R2592 T3228 T3229 arg1Of interact,with
R2593 T3228 T3232 arg1Of interact,and
R2594 T3231 T3229 arg2Of signaling,with
R2595 T3231 T3230 arg1Of signaling,TGF-β
R2596 T3234 T3232 arg2Of prevent,and
R2597 T3234 T3233 arg1Of prevent,thus
R2598 T3236 T3234 arg2Of induction,prevent
R2599 T3236 T3235 arg1Of induction,FOXP3
R2600 T3240 T3239 arg1Of neutralization,the
R2601 T3240 T3241 arg1Of neutralization,of
R2602 T3240 T3248 arg1Of neutralization,did
R2603 T3240 T3250 arg1Of neutralization,rescue
R2604 T3242 T3241 arg2Of IL-4,of
R2605 T3242 T3243 arg1Of IL-4,with
R2606 T3247 T3243 arg2Of antibody,with
R2607 T3247 T3244 arg1Of antibody,a
R2608 T3247 T3245 arg1Of antibody,blocking
R2609 T3247 T3246 arg1Of antibody,IL-4
R2610 T3250 T3237 arg1Of rescue,However
R2611 T3250 T3238 arg1Of rescue,","
R2612 T3250 T3248 arg2Of rescue,did
R2613 T3250 T3249 arg1Of rescue,not
R2614 T3250 T3253 arg1Of rescue,in
R2615 T3252 T3250 arg2Of expression,rescue
R2616 T3252 T3251 arg1Of expression,FOXP3
R2617 T3257 T3253 arg2Of cells,in
R2618 T3257 T3254 arg1Of cells,the
R2619 T3257 T3255 arg2Of cells,differentiated
R2620 T3257 T3256 arg1Of cells,Th2
R2621 T3257 T3258 arg1Of cells,(
R2622 T3260 T3258 arg2Of data,(
R2623 T3260 T3259 arg1Of data,unpublished
R2624 T3261 T3258 arg3Of ),(
R2625 T3263 T3262 arg1Of data,These
R2626 T3263 T3264 arg1Of data,demonstrated
R2627 T3267 T3266 arg1Of cells,Th2
R2628 T3267 T3268 arg1Of cells,have
R2629 T3268 T3264 arg2Of have,demonstrated
R2630 T3268 T3265 arg1Of have,that
R2631 T3271 T3268 arg2Of capacity,have
R2632 T3271 T3269 arg1Of capacity,a
R2633 T3271 T3270 arg2Of capacity,limited
R2634 T3271 T3272 modOf capacity,to
R2635 T3273 T3272 arg1Of express,to
R2636 T3274 T3273 arg2Of FOXP3,express
R2637 T3274 T3275 arg1Of FOXP3,(
R2638 T3277 T3275 arg2Of 1B,(
R2639 T3277 T3276 arg1Of 1B,Figure
R2640 T3278 T3275 arg3Of ),(
R2641 T3280 T3279 arg1Of inability,The
R2642 T3280 T3281 arg1Of inability,of
R2643 T3280 T3284 modOf inability,to
R2644 T3280 T3287 arg1Of inability,was
R2645 T3280 T3289 arg2Of inability,documented
R2646 T3283 T3281 arg2Of cells,of
R2647 T3283 T3282 arg1Of cells,Th2
R2648 T3285 T3284 arg1Of express,to
R2649 T3286 T3285 arg2Of FOXP3,express
R2650 T3289 T3287 arg2Of documented,was
R2651 T3289 T3288 arg1Of documented,also
R2652 T3289 T3290 arg1Of documented,at
R2653 T3289 T3294 arg1Of documented,","
R2654 T3289 T3295 modOf documented,confirming
R2655 T3293 T3290 arg2Of level,at
R2656 T3293 T3291 arg1Of level,the
R2657 T3293 T3292 arg1Of level,single-cell
R2658 T3298 T3297 arg1Of cells,Th2
R2659 T3298 T3299 arg1Of cells,lack
R2660 T3299 T3295 arg2Of lack,confirming
R2661 T3299 T3296 arg1Of lack,that
R2662 T3301 T3299 arg2Of expression,lack
R2663 T3301 T3300 arg1Of expression,FOXP3
R2664 T3301 T3302 arg1Of expression,(
R2665 T3304 T3302 arg2Of 2A,(
R2666 T3304 T3303 arg1Of 2A,Figure
R2667 T3305 T3302 arg3Of ),(
R2668 T3308 T3306 arg1Of cells,Only
R2669 T3308 T3307 arg1Of cells,iTreg
R2670 T3308 T3309 arg1Of cells,expressed
R2671 T3309 T3311 arg1Of expressed,in
R2672 T3310 T3309 arg2Of FOXP3,expressed
R2673 T3313 T3311 arg2Of conditions,in
R2674 T3313 T3312 arg1Of conditions,resting
R2675 T3316 T3317 arg1Of we,observed
R2676 T3317 T3314 arg1Of observed,Interestingly
R2677 T3317 T3315 arg1Of observed,","
R2678 T3321 T3319 arg1Of cells,resting
R2679 T3321 T3320 arg1Of cells,iTreg
R2680 T3321 T3322 arg1Of cells,express
R2681 T3321 T3325 arg1Of cells,show
R2682 T3322 T3324 arg1Of express,but
R2683 T3323 T3322 arg2Of FOXP3,express
R2684 T3324 T3317 arg2Of but,observed
R2685 T3324 T3318 arg1Of but,that
R2686 T3325 T3324 arg2Of show,but
R2687 T3329 T3325 arg2Of expression,show
R2688 T3329 T3326 arg1Of expression,low
R2689 T3329 T3327 arg1Of expression,CD25
R2690 T3329 T3328 arg1Of expression,surface
R2691 T3331 T3330 arg2Of exposure,Repeated
R2692 T3331 T3332 arg1Of exposure,to
R2693 T3331 T3334 arg1Of exposure,did
R2694 T3331 T3337 arg1Of exposure,increase
R2695 T3331 T3347 arg1Of exposure,induced
R2696 T3333 T3332 arg2Of TGF-β,to
R2697 T3337 T3334 arg2Of increase,did
R2698 T3337 T3335 arg1Of increase,not
R2699 T3337 T3336 arg1Of increase,further
R2700 T3337 T3345 arg1Of increase,but
R2701 T3340 T3337 arg2Of expression,increase
R2702 T3340 T3338 arg1Of expression,the
R2703 T3340 T3339 arg1Of expression,FOXP3
R2704 T3340 T3341 arg1Of expression,in
R2705 T3344 T3341 arg2Of lineage,in
R2706 T3344 T3342 arg1Of lineage,the
R2707 T3344 T3343 arg1Of lineage,iTreg
R2708 T3347 T3345 arg2Of induced,but
R2709 T3347 T3346 arg1Of induced,transiently
R2710 T3349 T3347 arg2Of expression,induced
R2711 T3349 T3348 arg1Of expression,FOXP3
R2712 T3349 T3350 arg1Of expression,in
R2713 T3352 T3350 arg2Of cells,in
R2714 T3352 T3351 arg1Of cells,Th1
R2715 T3354 T3353 arg1Of occurring,Naturally
R2716 T3356 T3354 arg1Of cells,occurring
R2717 T3356 T3355 arg1Of cells,Th2
R2718 T3356 T3358 arg1Of cells,as
R2719 T3356 T3372 arg1Of cells,or
R2720 T3358 T3357 arg1Of as,such
R2721 T3361 T3358 arg2Of cells,as
R2722 T3361 T3359 arg1Of cells,CRTH2+
R2723 T3361 T3360 arg1Of cells,T
R2724 T3361 T3362 arg1Of cells,","
R2725 T3364 T3362 arg2Of cells,","
R2726 T3364 T3363 arg1Of cells,T
R2727 T3364 T3365 arg2Of cells,isolated
R2728 T3365 T3366 arg1Of isolated,according
R2729 T3367 T3366 arg2Of to,according
R2730 T3370 T3367 arg2Of secretion,to
R2731 T3370 T3368 arg1Of secretion,their
R2732 T3370 T3369 arg1Of secretion,IL-4
R2733 T3372 T3371 arg1Of or,","
R2734 T3372 T3381 arg1Of or,were
R2735 T3372 T3383 arg1Of or,lacking
R2736 T3377 T3372 arg2Of clone,or
R2737 T3377 T3373 arg1Of clone,an
R2738 T3377 T3374 arg1Of clone,IL-4–producing
R2739 T3377 T3375 arg1Of clone,T
R2740 T3377 T3376 arg1Of clone,cell
R2741 T3377 T3378 arg1Of clone,(
R2742 T3379 T3378 arg2Of BR8,(
R2743 T3380 T3378 arg3Of ),(
R2744 T3383 T3381 arg2Of lacking,were
R2745 T3383 T3382 arg1Of lacking,also
R2746 T3385 T3383 arg2Of expression,lacking
R2747 T3385 T3384 arg1Of expression,FOXP3
R2748 T3385 T3386 arg1Of expression,(
R2749 T3388 T3386 arg2Of 2B,(
R2750 T3388 T3387 arg1Of 2B,Figure
R2751 T3389 T3386 arg3Of ),(
R2752 T3393 T3390 arg1Of induction,Furthermore
R2753 T3393 T3391 arg1Of induction,TGF-β–mediated
R2754 T3393 T3392 arg1Of induction,FOXP3
R2755 T3393 T3394 arg1Of induction,failed
R2756 T3394 T3395 arg1Of failed,in
R2757 T3394 T3398 arg1Of failed,in
R2758 T3397 T3395 arg2Of cells,in
R2759 T3397 T3396 arg1Of cells,these
R2760 T3398 T3400 arg1Of in,to
R2761 T3399 T3398 arg2Of contrast,in
R2762 T3404 T3398 arg3Of cells,in
R2763 T3404 T3401 arg1Of cells,the
R2764 T3404 T3402 arg1Of cells,naive
R2765 T3404 T3403 arg1Of cells,T
R2766 T3404 T3405 arg1Of cells,(
R2767 T3407 T3405 arg2Of 2B,(
R2768 T3407 T3406 arg1Of 2B,Figure
R2769 T3408 T3405 arg3Of ),(
R2770 T3410 T3411 arg1Of IL-4,is
R2771 T3411 T3409 arg2Of is,Because
R2772 T3415 T3411 arg2Of cytokine,is
R2773 T3415 T3412 arg1Of cytokine,the
R2774 T3415 T3413 arg1Of cytokine,key
R2775 T3415 T3414 arg1Of cytokine,Th2
R2776 T3418 T3417 arg1Of expression,the
R2777 T3418 T3419 arg1Of expression,of
R2778 T3418 T3423 arg1Of expression,in
R2779 T3418 T3429 arg1Of expression,was
R2780 T3418 T3430 arg2Of expression,analyzed
R2781 T3420 T3421 arg1Of IL-4,and
R2782 T3421 T3419 arg2Of and,of
R2783 T3422 T3421 arg2Of FOXP3,and
R2784 T3428 T3423 arg2Of cells,in
R2785 T3428 T3424 arg1Of cells,freshly
R2786 T3428 T3425 arg2Of cells,isolated
R2787 T3428 T3426 arg1Of cells,CD4+
R2788 T3428 T3427 arg1Of cells,T
R2789 T3430 T3409 arg1Of analyzed,Because
R2790 T3430 T3416 arg1Of analyzed,","
R2791 T3430 T3429 arg2Of analyzed,was
R2792 T3435 T3430 arg1Of sorting,analyzed
R2793 T3435 T3431 arg2Of sorting,by
R2794 T3435 T3432 arg1Of sorting,fluorescence
R2795 T3435 T3433 arg2Of sorting,activated
R2796 T3435 T3434 arg1Of sorting,cell
R2797 T3435 T3436 arg1Of sorting,(
R2798 T3437 T3436 arg2Of FACS,(
R2799 T3438 T3436 arg3Of ),(
R2800 T3440 T3439 arg1Of cells,IL-4–expressing
R2801 T3440 T3441 arg1Of cells,were
R2802 T3440 T3443 arg1Of cells,abundant
R2803 T3443 T3441 arg2Of abundant,were
R2804 T3443 T3442 arg1Of abundant,most
R2805 T3443 T3444 arg1Of abundant,among
R2806 T3446 T3444 arg2Of cells,among
R2807 T3446 T3445 arg1Of cells,CD45RO+CD25–
R2808 T3446 T3447 arg1Of cells,","
R2809 T3446 T3448 arg1Of cells,which
R2810 T3446 T3449 arg1Of cells,did
R2811 T3446 T3451 arg1Of cells,co-express
R2812 T3451 T3449 arg2Of co-express,did
R2813 T3451 T3450 arg1Of co-express,not
R2814 T3452 T3451 arg2Of FOXP3,co-express
R2815 T3452 T3453 arg1Of FOXP3,(
R2816 T3455 T3453 arg2Of 3A,(
R2817 T3455 T3454 arg1Of 3A,Figure
R2818 T3455 T3456 arg1Of 3A,","
R2819 T3458 T3456 arg2Of panel,","
R2820 T3458 T3457 arg1Of panel,left
R2821 T3459 T3453 arg3Of ),(
R2822 T3461 T3460 arg2Of contrast,In
R2823 T3464 T3463 arg1Of cells,CD45RO+CD25+
R2824 T3464 T3466 arg1Of cells,expressed
R2825 T3464 T3470 arg1Of cells,lacking
R2826 T3466 T3460 arg1Of expressed,In
R2827 T3466 T3462 arg1Of expressed,","
R2828 T3466 T3465 arg1Of expressed,abundantly
R2829 T3466 T3468 arg1Of expressed,","
R2830 T3466 T3469 arg1Of expressed,while
R2831 T3467 T3466 arg2Of FOXP3,expressed
R2832 T3470 T3469 arg2Of lacking,while
R2833 T3471 T3470 arg2Of IL-4,lacking
R2834 T3471 T3472 arg1Of IL-4,(
R2835 T3474 T3472 arg2Of 3A,(
R2836 T3474 T3473 arg1Of 3A,Figure
R2837 T3474 T3475 arg1Of 3A,","
R2838 T3477 T3475 arg2Of panel,","
R2839 T3477 T3476 arg1Of panel,right
R2840 T3478 T3472 arg3Of ),(
R2841 T3480 T3479 arg2Of shown,As
R2842 T3480 T3481 arg1Of shown,in
R2843 T3483 T3481 arg2Of 3B,in
R2844 T3483 T3482 arg1Of 3B,Figure
R2845 T3486 T3485 arg1Of frequency,the
R2846 T3486 T3487 arg1Of frequency,of
R2847 T3486 T3491 arg1Of frequency,was
R2848 T3486 T3493 arg1Of frequency,below
R2849 T3490 T3487 arg2Of cells,of
R2850 T3490 T3488 arg1Of cells,the
R2851 T3490 T3489 arg1Of cells,IL-4+
R2852 T3491 T3479 arg1Of was,As
R2853 T3491 T3484 arg1Of was,","
R2854 T3491 T3492 arg1Of was,always
R2855 T3491 T3496 arg1Of was,in
R2856 T3493 T3491 arg2Of below,was
R2857 T3495 T3493 arg2Of %,below
R2858 T3495 T3494 arg1Of %,1
R2859 T3499 T3496 arg2Of cells,in
R2860 T3499 T3497 arg1Of cells,the
R2861 T3499 T3498 arg1Of cells,FOXP3+
R2862 T3499 T3500 arg1Of cells,close
R2863 T3500 T3501 arg1Of close,to
R2864 T3503 T3501 arg2Of background,to
R2865 T3503 T3502 arg1Of background,the
R2866 T3506 T3504 arg1Of cells,The
R2867 T3506 T3505 arg1Of cells,IL-4+
R2868 T3506 T3507 arg1Of cells,were
R2869 T3506 T3508 arg2Of cells,confined
R2870 T3508 T3507 arg2Of confined,were
R2871 T3508 T3509 arg1Of confined,to
R2872 T3508 T3513 arg1Of confined,","
R2873 T3508 T3514 arg1Of confined,as
R2874 T3512 T3509 arg2Of cells,to
R2875 T3512 T3510 arg1Of cells,the
R2876 T3512 T3511 arg1Of cells,FOXP3–
R2877 T3515 T3514 arg2Of shown,as
R2878 T3515 T3516 arg1Of shown,for
R2879 T3518 T3519 arg1Of CD45RO+CD25–,","
R2880 T3520 T3522 arg1Of CD45RO+CD25+,and
R2881 T3522 T3519 arg2Of and,","
R2882 T3522 T3521 arg1Of and,","
R2883 T3523 T3522 arg2Of CD45RO+CD25+high,and
R2884 T3524 T3516 arg2Of cells,for
R2885 T3524 T3517 arg1Of cells,the
R2886 T3524 T3518 arg1Of cells,CD45RO+CD25–
R2887 T3524 T3520 arg1Of cells,CD45RO+CD25+
R2888 T3524 T3523 arg1Of cells,CD45RO+CD25+high
R2889 T3524 T3525 arg1Of cells,(
R2890 T3527 T3525 arg2Of 3B,(
R2891 T3527 T3526 arg1Of 3B,Figure
R2892 T3528 T3525 arg3Of ),(
R2893 T3530 T3529 arg2Of addition,In
R2894 T3535 T3534 arg1Of clone,Th2
R2895 T3535 T3536 arg1Of clone,(
R2896 T3535 T3539 arg1Of clone,nor
R2897 T3537 T3536 arg2Of BR8,(
R2898 T3538 T3536 arg3Of ),(
R2899 T3539 T3532 arg1Of nor,neither
R2900 T3539 T3533 arg1Of nor,the
R2901 T3539 T3543 arg1Of nor,expressed
R2902 T3541 T3539 arg2Of cells,nor
R2903 T3541 T3540 arg1Of cells,CRTH2
R2904 T3543 T3529 arg1Of expressed,In
R2905 T3543 T3531 arg1Of expressed,","
R2906 T3543 T3542 arg1Of expressed,significantly
R2907 T3544 T3543 arg2Of FOXP3,expressed
R2908 T3544 T3545 arg1Of FOXP3,(
R2909 T3547 T3545 arg2Of 3C,(
R2910 T3547 T3546 arg1Of 3C,Figure
R2911 T3548 T3545 arg3Of ),(
R2912 T3549 T3550 arg2Of Cells,enriched
R2913 T3549 T3561 arg1Of Cells,contained
R2914 T3550 T3551 arg1Of enriched,for
R2915 T3554 T3551 arg2Of secretion,for
R2916 T3554 T3552 arg1Of secretion,their
R2917 T3554 T3553 arg1Of secretion,IL-4
R2918 T3554 T3555 arg1Of secretion,using
R2919 T3560 T3555 arg2Of technology,using
R2920 T3560 T3556 arg1Of technology,the
R2921 T3560 T3557 arg1Of technology,magnetic
R2922 T3560 T3558 arg1Of technology,cell
R2923 T3560 T3559 arg1Of technology,isolation
R2924 T3561 T3566 arg1Of contained,but
R2925 T3564 T3561 arg2Of cells,contained
R2926 T3564 T3562 arg1Of cells,some
R2927 T3564 T3563 arg1Of cells,FOXP3-expressing
R2928 T3566 T3565 arg1Of but,","
R2929 T3570 T3569 arg1Of expression,the
R2930 T3570 T3571 arg1Of expression,did
R2931 T3570 T3573 arg1Of expression,overlap
R2932 T3573 T3566 arg2Of overlap,but
R2933 T3573 T3567 arg1Of overlap,importantly
R2934 T3573 T3568 arg1Of overlap,","
R2935 T3573 T3571 arg2Of overlap,did
R2936 T3573 T3572 arg1Of overlap,not
R2937 T3574 T3575 arg1Of Taken,together
R2938 T3578 T3577 arg1Of data,these
R2939 T3578 T3579 arg1Of data,indicate
R2940 T3579 T3574 modOf indicate,Taken
R2941 T3579 T3576 arg1Of indicate,","
R2942 T3581 T3582 arg1Of FOXP3,was
R2943 T3581 T3584 arg2Of FOXP3,expressed
R2944 T3581 T3589 arg1Of FOXP3,was
R2945 T3581 T3591 arg1Of FOXP3,inducible
R2946 T3584 T3582 arg2Of expressed,was
R2947 T3584 T3583 arg1Of expressed,not
R2948 T3584 T3588 arg1Of expressed,and
R2949 T3587 T3584 arg1Of cells,expressed
R2950 T3587 T3585 arg2Of cells,by
R2951 T3587 T3586 arg1Of cells,Th2
R2952 T3588 T3579 arg2Of and,indicate
R2953 T3588 T3580 arg1Of and,that
R2954 T3589 T3588 arg2Of was,and
R2955 T3589 T3590 arg1Of was,not
R2956 T3589 T3592 arg1Of was,in
R2957 T3591 T3589 arg2Of inducible,was
R2958 T3594 T3592 arg2Of cells,in
R2959 T3594 T3593 arg1Of cells,those
R17595 T23465 T23464 arg1Of Cells,Th2
R17596 T23465 T23466 arg1Of Cells,Can
R17597 T23465 T23468 arg1Of Cells,Induce
R17598 T23468 T23466 arg2Of Induce,Can
R17599 T23468 T23467 arg1Of Induce,not
R17600 T23470 T23468 arg2Of Expression,Induce
R17601 T23470 T23469 arg1Of Expression,FOXP3
R17602 T23472 T23471 arg2Of A,(
R17603 T23473 T23471 arg3Of ),(
R17604 T23476 T23471 arg1Of cells,(
R17605 T23476 T23474 arg1Of cells,Human
R17606 T23476 T23475 arg1Of cells,T
R17607 T23476 T23477 arg1Of cells,were
R17608 T23476 T23478 arg2Of cells,activated
R17609 T23478 T23477 arg2Of activated,were
R17610 T23478 T23479 arg1Of activated,with
R17611 T23478 T23482 arg1Of activated,with
R17612 T23478 T23484 arg1Of activated,without
R17613 T23478 T23486 arg1Of activated,as
R17614 T23481 T23479 arg2Of anti-CD3/CD28,with
R17615 T23481 T23480 arg1Of anti-CD3/CD28,plate-bound
R17616 T23482 T23483 arg1Of with,or
R17617 T23484 T23483 arg2Of without,or
R17618 T23485 T23482 arg2Of TGF-β,with
R17619 T23485 T23484 arg2Of TGF-β,without
R17620 T23487 T23486 arg2Of indicated,as
R17621 T23487 T23488 arg1Of indicated,on
R17622 T23490 T23488 arg2Of x-axis,on
R17623 T23490 T23489 arg1Of x-axis,the
R17624 T23490 T23491 arg1Of x-axis,of
R17625 T23490 T23492 arg1Of x-axis,(
R17626 T23493 T23492 arg2Of B,(
R17627 T23494 T23492 arg3Of ),(
R17628 T23495 T23496 arg1Of Cells,were
R17629 T23495 T23497 arg2Of Cells,harvested
R17630 T23497 T23496 arg2Of harvested,were
R17631 T23497 T23498 arg1Of harvested,after
R17632 T23497 T23501 arg1Of harvested,and
R17633 T23500 T23498 arg2Of days,after
R17634 T23500 T23499 arg1Of days,5
R17635 T23503 T23502 arg1Of mRNA,FOXP3
R17636 T23503 T23504 arg1Of mRNA,was
R17637 T23503 T23505 arg2Of mRNA,quantified
R17638 T23505 T23501 arg2Of quantified,and
R17639 T23505 T23504 arg2Of quantified,was
R17640 T23508 T23505 arg1Of PCR,quantified
R17641 T23508 T23506 arg2Of PCR,by
R17642 T23508 T23507 arg1Of PCR,real-time
R17643 T23509 T23510 arg1Of Bars,show
R17644 T23514 T23510 arg2Of SD,show
R17645 T23514 T23511 arg1Of SD,the
R17646 T23514 T23512 arg1Of SD,mean
R17647 T23514 T23513 arg1Of SD,±
R17648 T23514 T23515 arg1Of SD,of
R17649 T23518 T23515 arg2Of experiments,of
R17650 T23518 T23516 arg1Of experiments,4
R17651 T23518 T23517 arg1Of experiments,independent
R17652 T23520 T23519 arg2Of B,(
R17653 T23521 T23519 arg3Of ),(
R17654 T23523 T23522 arg1Of vitro,In
R17655 T23524 T23523 arg1Of differentiated,vitro
R17656 T23525 T23526 arg1Of Th1,","
R17657 T23526 T23529 arg1Of ",",or
R17658 T23527 T23526 arg2Of Th2,","
R17659 T23529 T23528 arg1Of or,","
R17660 T23530 T23529 arg2Of iTreg,or
R17661 T23531 T23519 arg1Of cells,(
R17662 T23531 T23524 arg1Of cells,differentiated
R17663 T23531 T23525 arg1Of cells,Th1
R17664 T23531 T23527 arg1Of cells,Th2
R17665 T23531 T23530 arg1Of cells,iTreg
R17666 T23531 T23532 arg1Of cells,were
R17667 T23531 T23533 arg2Of cells,activated
R17668 T23533 T23532 arg2Of activated,were
R17669 T23533 T23534 arg1Of activated,with
R17670 T23533 T23541 arg1Of activated,as
R17671 T23535 T23536 arg1Of anti-CD3/CD28,","
R17672 T23536 T23539 arg1Of ",",or
R17673 T23537 T23536 arg2Of TGF-β,","
R17674 T23539 T23534 arg2Of or,with
R17675 T23539 T23538 arg1Of or,","
R17676 T23540 T23539 arg2Of anti-IL-4,or
R17677 T23542 T23541 arg2Of indicated,as
R17678 T23544 T23543 arg1Of phenotype,The
R17679 T23544 T23545 arg1Of phenotype,of
R17680 T23544 T23548 arg1Of phenotype,was
R17681 T23544 T23549 arg2Of phenotype,confirmed
R17682 T23547 T23545 arg2Of cells,of
R17683 T23547 T23546 arg1Of cells,these
R17684 T23549 T23548 arg2Of confirmed,was
R17685 T23551 T23552 arg1Of FACS,and
R17686 T23553 T23552 arg2Of proliferation,and
R17687 T23554 T23549 arg1Of analysis,confirmed
R17688 T23554 T23550 arg2Of analysis,by
R17689 T23554 T23551 arg1Of analysis,FACS
R17690 T23554 T23553 arg1Of analysis,proliferation
R17691 T23554 T23555 arg1Of analysis,(
R17692 T23557 T23555 arg2Of S1,(
R17693 T23557 T23556 arg1Of S1,Figure
R17694 T23558 T23555 arg3Of ),(
R17695 T23559 T23560 arg1Of Bars,show
R17696 T23564 T23560 arg2Of SD,show
R17697 T23564 T23561 arg1Of SD,the
R17698 T23564 T23562 arg1Of SD,mean
R17699 T23564 T23563 arg1Of SD,±
R17700 T23564 T23565 arg1Of SD,of
R17701 T23568 T23565 arg2Of experiments,of
R17702 T23568 T23566 arg1Of experiments,four
R17703 T23568 T23567 arg1Of experiments,independent
R17844 T23816 T23815 arg1Of Cells,Th2
R17845 T23816 T23817 arg1Of Cells,Do
R17846 T23819 T23818 arg1Of Express,Not
R17847 T23820 T23817 arg2Of FOXP3,Do
R17848 T23820 T23819 arg1Of FOXP3,Express
R17849 T23822 T23821 arg2Of A,(
R17850 T23823 T23821 arg3Of ),(
R17851 T23826 T23821 arg1Of analysis,(
R17852 T23826 T23824 arg1Of analysis,Intracellular
R17853 T23826 T23825 arg1Of analysis,FACS
R17854 T23826 T23827 arg1Of analysis,of
R17855 T23826 T23830 arg1Of analysis,in
R17856 T23826 T23838 arg1Of analysis,(
R17857 T23826 T23847 arg1Of analysis,","
R17858 T23826 T23848 arg2Of analysis,rested
R17859 T23826 T23850 arg2Of analysis,activated
R17860 T23829 T23827 arg2Of expression,of
R17861 T23829 T23828 arg1Of expression,FOXP3
R17862 T23831 T23832 arg1Of Th1,","
R17863 T23832 T23835 arg1Of ",",or
R17864 T23833 T23832 arg2Of Th2,","
R17865 T23835 T23834 arg1Of or,","
R17866 T23836 T23835 arg2Of iTreg-differentiated,or
R17867 T23837 T23830 arg2Of cells,in
R17868 T23837 T23831 arg1Of cells,Th1
R17869 T23837 T23833 arg1Of cells,Th2
R17870 T23837 T23836 arg1Of cells,iTreg-differentiated
R17871 T23840 T23839 arg1Of rounds,two
R17872 T23840 T23841 arg1Of rounds,","
R17873 T23840 T23843 arg1Of rounds,see
R17874 T23842 T23841 arg2Of phenotype,","
R17875 T23843 T23838 arg2Of see,(
R17876 T23845 T23843 arg2Of S1,see
R17877 T23845 T23844 arg1Of S1,Figure
R17878 T23846 T23838 arg3Of ),(
R17879 T23848 T23849 arg1Of rested,or
R17880 T23849 T23851 arg1Of or,","
R17881 T23849 T23852 arg1Of or,with
R17882 T23849 T23854 arg1Of or,without
R17883 T23850 T23849 arg2Of activated,or
R17884 T23852 T23853 arg1Of with,or
R17885 T23854 T23853 arg2Of without,or
R17886 T23855 T23852 arg2Of TGF-β,with
R17887 T23855 T23854 arg2Of TGF-β,without
R17888 T23857 T23856 arg1Of expression,FOXP3
R17889 T23857 T23858 arg1Of expression,was
R17890 T23857 T23859 arg2Of expression,measured
R17891 T23859 T23858 arg2Of measured,was
R17892 T23859 T23860 arg1Of measured,after
R17893 T23862 T23860 arg2Of d,after
R17894 T23862 T23861 arg1Of d,5
R17895 T23862 T23863 arg1Of d,in
R17896 T23864 T23863 arg2Of culture,in
R17897 T23867 T23865 arg1Of blots,The
R17898 T23867 T23866 arg1Of blots,dot
R17899 T23867 T23868 arg1Of blots,are
R17900 T23867 T23869 arg1Of blots,representative
R17901 T23869 T23868 arg2Of representative,are
R17902 T23869 T23870 arg1Of representative,of
R17903 T23873 T23870 arg2Of experiments,of
R17904 T23873 T23871 arg1Of experiments,three
R17905 T23873 T23872 arg1Of experiments,independent
R17906 T23875 T23874 arg2Of B,(
R17907 T23875 T23877 arg1Of B,Shows
R17908 T23876 T23874 arg3Of ),(
R17909 T23877 T23883 arg1Of Shows,but
R17910 T23881 T23877 arg2Of setup,Shows
R17911 T23881 T23878 arg1Of setup,the
R17912 T23881 T23879 arg1Of setup,same
R17913 T23881 T23880 arg1Of setup,experimental
R17914 T23883 T23882 arg1Of but,","
R17915 T23885 T23884 arg1Of occurring,naturally
R17916 T23887 T23885 arg1Of cells,occurring
R17917 T23887 T23886 arg1Of cells,Th2
R17918 T23887 T23888 arg1Of cells,were
R17919 T23887 T23889 arg2Of cells,analyzed
R17920 T23889 T23883 arg2Of analyzed,but
R17921 T23889 T23888 arg2Of analyzed,were
R17922 T23890 T23891 arg1Of Data,are
R17923 T23890 T23892 arg1Of Data,representative
R17924 T23892 T23891 arg2Of representative,are
R17925 T23892 T23893 arg1Of representative,of
R17926 T23896 T23893 arg2Of experiments,of
R17927 T23896 T23894 arg1Of experiments,three
R17928 T23896 T23895 arg1Of experiments,independent
R18062 T24133 T24134 arg1Of Th2-,or
R18063 T24138 T24134 arg2Of FOXP3,or
R18064 T24138 T24135 arg1Of FOXP3,IL-4–Producing
R18065 T24138 T24136 arg1Of FOXP3,Cells
R18066 T24138 T24137 arg1Of FOXP3,Lack
R18067 T24140 T24139 arg2Of A,(
R18068 T24141 T24139 arg3Of ),(
R18069 T24143 T24139 arg1Of analysis,(
R18070 T24143 T24142 arg1Of analysis,FACS
R18071 T24143 T24144 arg1Of analysis,of
R18072 T24143 T24150 arg1Of analysis,following
R18073 T24146 T24147 arg1Of FOXP3,and
R18074 T24148 T24147 arg2Of IL-4,and
R18075 T24149 T24144 arg2Of expression,of
R18076 T24149 T24145 arg1Of expression,intracellular
R18077 T24149 T24146 arg1Of expression,FOXP3
R18078 T24149 T24148 arg1Of expression,IL-4
R18079 T24152 T24150 arg2Of stimulation,following
R18080 T24152 T24151 arg1Of stimulation,PMA/Ionomycin
R18081 T24155 T24153 arg1Of cells,CD4+
R18082 T24155 T24154 arg1Of cells,T
R18083 T24155 T24156 arg1Of cells,were
R18084 T24155 T24157 arg2Of cells,gated
R18085 T24157 T24156 arg2Of gated,were
R18086 T24157 T24158 arg1Of gated,on
R18087 T24157 T24172 arg1Of gated,and
R18088 T24160 T24158 arg2Of basis,on
R18089 T24160 T24159 arg1Of basis,the
R18090 T24160 T24161 arg1Of basis,of
R18091 T24162 T24163 arg1Of CD45RO,and
R18092 T24164 T24163 arg2Of CD25,and
R18093 T24166 T24161 arg2Of expression,of
R18094 T24166 T24162 arg1Of expression,CD45RO
R18095 T24166 T24164 arg1Of expression,CD25
R18096 T24166 T24165 arg1Of expression,surface
R18097 T24166 T24167 arg1Of expression,(
R18098 T24169 T24167 arg2Of panel,(
R18099 T24169 T24168 arg1Of panel,upper
R18100 T24170 T24167 arg3Of ),(
R18101 T24172 T24171 arg1Of and,","
R18102 T24174 T24173 arg2Of cells,gated
R18103 T24174 T24175 arg1Of cells,are
R18104 T24174 T24176 arg2Of cells,shown
R18105 T24176 T24172 arg2Of shown,and
R18106 T24176 T24175 arg2Of shown,are
R18107 T24176 T24177 arg1Of shown,below
R18108 T24176 T24178 arg1Of shown,for
R18109 T24180 T24179 arg1Of CD45RO+CD25−,the
R18110 T24180 T24181 arg1Of CD45RO+CD25−,(
R18111 T24180 T24187 arg1Of CD45RO+CD25−,","
R18112 T24180 T24195 arg1Of CD45RO+CD25−,and
R18113 T24182 T24181 arg2Of A,(
R18114 T24182 T24183 arg1Of A,","
R18115 T24185 T24183 arg2Of panel,","
R18116 T24185 T24184 arg1Of panel,left
R18117 T24186 T24181 arg3Of ),(
R18118 T24189 T24187 arg2Of CD45RO+CD25+,","
R18119 T24189 T24188 arg1Of CD45RO+CD25+,the
R18120 T24189 T24190 arg1Of CD45RO+CD25+,(
R18121 T24192 T24190 arg2Of panel,(
R18122 T24192 T24191 arg1Of panel,right
R18123 T24193 T24190 arg3Of ),(
R18124 T24195 T24178 arg2Of and,for
R18125 T24195 T24194 arg1Of and,","
R18126 T24198 T24195 arg2Of subsets,and
R18127 T24198 T24196 arg1Of subsets,the
R18128 T24198 T24197 arg1Of subsets,CD45RO−CD25−
R18129 T24198 T24199 arg1Of subsets,(
R18130 T24201 T24199 arg2Of panel,(
R18131 T24201 T24200 arg1Of panel,central
R18132 T24202 T24199 arg3Of ),(
R18133 T24205 T24203 arg1Of analysis,A
R18134 T24205 T24204 arg1Of analysis,statistical
R18135 T24205 T24206 arg1Of analysis,of
R18136 T24205 T24210 arg1Of analysis,after
R18137 T24205 T24216 arg1Of analysis,are
R18138 T24205 T24217 arg2Of analysis,shown
R18139 T24209 T24206 arg2Of donors,of
R18140 T24209 T24207 arg1Of donors,eight
R18141 T24209 T24208 arg1Of donors,independent
R18142 T24211 T24210 arg2Of subtraction,after
R18143 T24211 T24212 arg1Of subtraction,of
R18144 T24215 T24212 arg2Of control,of
R18145 T24215 T24213 arg1Of control,the
R18146 T24215 T24214 arg1Of control,isotype
R18147 T24217 T24216 arg2Of shown,are
R18148 T24217 T24218 arg1Of shown,in
R18149 T24220 T24218 arg2Of B,in
R18150 T24220 T24219 arg2Of B,(
R18151 T24221 T24219 arg3Of ),(
R18152 T24225 T24222 arg1Of line,The
R18153 T24225 T24223 arg2Of line,dotted
R18154 T24225 T24224 arg1Of line,gray
R18155 T24225 T24226 arg1Of line,indicates
R18156 T24230 T24226 arg2Of level,indicates
R18157 T24230 T24227 arg1Of level,the
R18158 T24230 T24228 arg1Of level,IC
R18159 T24230 T24229 arg1Of level,background
R18160 T24233 T24231 arg1Of bars,The
R18161 T24233 T24232 arg1Of bars,error
R18162 T24233 T24234 arg1Of bars,show
R18163 T24234 T24243 arg1Of show,Similarly
R18164 T24234 T24244 arg1Of show,","
R18165 T24234 T24259 arg1Of show,and
R18166 T24236 T24234 arg2Of error,show
R18167 T24236 T24235 arg1Of error,the
R18168 T24236 T24237 arg1Of error,of
R18169 T24239 T24237 arg2Of mean.,of
R18170 T24239 T24238 arg1Of mean.,the
R18171 T24239 T24240 arg1Of mean.,(
R18172 T24241 T24240 arg2Of C,(
R18173 T24242 T24240 arg3Of ),(
R18174 T24247 T24234 arg3Of clone,show
R18175 T24247 T24245 arg1Of clone,a
R18176 T24247 T24246 arg1Of clone,Th2
R18177 T24247 T24248 arg1Of clone,(
R18178 T24247 T24251 arg1Of clone,","
R18179 T24247 T24255 arg1Of clone,","
R18180 T24249 T24248 arg2Of BR8,(
R18181 T24250 T24248 arg3Of ),(
R18182 T24254 T24251 arg2Of cells,","
R18183 T24254 T24252 arg1Of cells,CRTH2+
R18184 T24254 T24253 arg1Of cells,Th2
R18185 T24257 T24255 arg2Of cells,","
R18186 T24257 T24256 arg1Of cells,IL-4-secreting
R18187 T24259 T24258 arg1Of and,","
R18188 T24262 T24260 arg1Of cells,memory
R18189 T24262 T24261 arg1Of cells,T
R18190 T24262 T24263 arg1Of cells,(
R18191 T24262 T24266 arg1Of cells,were
R18192 T24262 T24267 arg2Of cells,stained
R18193 T24264 T24263 arg2Of CD45RO,(
R18194 T24265 T24263 arg3Of ),(
R18195 T24267 T24259 arg2Of stained,and
R18196 T24267 T24266 arg2Of stained,were
R18197 T24267 T24268 arg1Of stained,for
R18198 T24269 T24270 arg1Of FOXP3,and
R18199 T24270 T24268 arg2Of and,for
R18200 T24271 T24270 arg2Of IL-4,and
R18201 T24272 T24273 arg1Of Data,are
R18202 T24272 T24274 arg1Of Data,representative
R18203 T24274 T24273 arg2Of representative,are
R18204 T24274 T24275 arg1Of representative,of
R18205 T24278 T24275 arg2Of experiments,of
R18206 T24278 T24276 arg1Of experiments,three
R18207 T24278 T24277 arg1Of experiments,independent

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T3688 0-5 CD denotes FOXP3
T3689 6-15 NNP denotes Induction
T3690 16-18 IN denotes in
T3691 19-20 NNP denotes T
T3692 21-25 NNP denotes Cell
T3693 26-33 NNPS denotes Subsets
T3694 34-36 PRP denotes It
T3695 37-39 VBZ denotes is
T3696 40-47 VBN denotes assumed
T3697 48-52 IN denotes that
T3698 53-58 CD denotes FOXP3
T3699 59-69 NN denotes expression
T3700 70-73 MD denotes can
T3701 74-76 VB denotes be
T3702 77-84 VBN denotes induced
T3703 85-87 IN denotes in
T3704 88-101 JJ denotes nonregulatory
T3705 102-103 NNP denotes T
T3706 104-109 NNS denotes cells
T3707 109-110 , denotes ,
T3708 111-116 WDT denotes which
T3709 117-119 VBZ denotes is
T3710 120-122 DT denotes an
T3711 123-132 JJ denotes important
T3712 133-137 NN denotes step
T3713 138-140 IN denotes in
T3714 141-146 NNP denotes iTreg
T3715 147-151 NN denotes cell
T3716 152-167 NN denotes differentiation
T3717 167-168 . denotes .
T3718 169-176 RB denotes However
T3719 176-177 , denotes ,
T3720 178-180 PRP denotes it
T3721 181-183 VBZ denotes is
T3722 184-187 RB denotes not
T3723 188-193 VBN denotes known
T3724 194-196 IN denotes if
T3725 197-200 DT denotes all
T3726 201-204 CD denotes CD4
T3727 204-205 NN denotes +
T3728 206-207 NNP denotes T
T3729 208-213 NNS denotes cells
T3730 214-218 VBP denotes have
T3731 219-222 DT denotes the
T3732 223-227 JJ denotes same
T3733 228-236 NN denotes capacity
T3734 237-239 TO denotes to
T3735 240-247 VB denotes express
T3736 248-253 NNP denotes FOXP3
T3737 253-254 . denotes .
T3738 255-257 TO denotes To
T3739 258-269 VB denotes investigate
T3740 270-277 IN denotes whether
T3741 278-283 NNP denotes FOXP3
T3742 284-287 MD denotes can
T3743 288-290 VB denotes be
T3744 291-300 VBN denotes expressed
T3745 301-303 IN denotes by
T3746 304-307 DT denotes any
T3747 308-309 NNP denotes T
T3748 310-314 NN denotes cell
T3749 315-321 NN denotes subset
T3750 322-324 CC denotes or
T3751 325-327 IN denotes if
T3752 328-338 NN denotes expression
T3753 339-341 VBZ denotes is
T3754 342-352 VBN denotes restricted
T3755 353-355 TO denotes to
T3756 356-357 DT denotes a
T3757 358-366 JJ denotes distinct
T3758 367-374 NN denotes lineage
T3759 374-375 , denotes ,
T3760 376-381 CD denotes FOXP3
T3761 382-386 NNP denotes mRNA
T3762 387-397 NN denotes expression
T3763 398-401 VBD denotes was
T3764 402-410 VBN denotes analyzed
T3765 411-413 IN denotes in
T3766 414-421 RB denotes freshly
T3767 422-430 VBN denotes isolated
T3768 431-432 NNP denotes T
T3769 433-438 NNS denotes cells
T3770 439-443 JJ denotes such
T3771 444-446 IN denotes as
T3772 447-460 JJ denotes CD25-depleted
T3773 461-464 NNP denotes CD4
T3774 464-465 NN denotes +
T3775 466-471 NNS denotes cells
T3776 471-472 , denotes ,
T3777 473-479 NNP denotes CD45RA
T3778 479-480 NNP denotes +
T3779 481-486 JJ denotes naive
T3780 487-489 CC denotes or
T3781 490-496 CD denotes CD45RO
T3782 496-497 JJ denotes +
T3783 498-504 NN denotes memory
T3784 505-506 NNP denotes T
T3785 507-512 NNS denotes cells
T3786 513-514 -LRB- denotes (
T3787 514-520 NN denotes Figure
T3788 521-523 CD denotes 1A
T3789 523-524 -RRB- denotes )
T3790 524-525 , denotes ,
T3791 526-528 RB denotes as
T3792 529-533 RB denotes well
T3793 534-536 IN denotes as
T3794 537-538 NNP denotes T
T3795 539-544 NNS denotes cells
T3796 545-551 VBN denotes driven
T3797 552-554 IN denotes in
T3798 555-560 NN denotes vitro
T3799 561-567 IN denotes toward
T3800 568-571 NNP denotes Th1
T3801 571-572 , denotes ,
T3802 573-576 NNP denotes Th2
T3803 576-577 , denotes ,
T3804 578-580 CC denotes or
T3805 581-586 NNP denotes iTreg
T3806 587-597 NNS denotes phenotypes
T3807 598-599 -LRB- denotes (
T3808 599-605 NN denotes Figure
T3809 606-608 CD denotes 1B
T3810 608-609 : denotes ;
T3811 610-619 NN denotes phenotype
T3812 620-622 IN denotes on
T3813 623-629 NN denotes Figure
T3814 630-632 CD denotes S1
T3815 632-633 -RRB- denotes )
T3816 633-634 . denotes .
T3817 635-638 DT denotes The
T3818 639-642 NNP denotes CD4
T3819 642-643 NNP denotes +
T3820 643-647 NNP denotes CD25
T3821 648-649 , denotes ,
T3822 650-656 NNP denotes CD45RA
T3823 656-657 NNP denotes +
T3824 657-658 , denotes ,
T3825 659-665 NNP denotes CD45RO
T3826 665-666 NNP denotes +
T3827 666-667 , denotes ,
T3828 668-671 CC denotes and
T3829 672-675 NNP denotes CD4
T3830 675-676 NNP denotes +
T3831 676-682 NNP denotes CD45RO
T3832 682-683 NNP denotes +
T3833 683-687 NNP denotes CD25
T3834 689-693 VBD denotes were
T3835 694-698 JJ denotes able
T3836 699-701 TO denotes to
T3837 702-715 RB denotes significantly
T3838 716-722 VB denotes induce
T3839 723-728 CD denotes FOXP3
T3840 729-733 NNP denotes mRNA
T3841 734-736 IN denotes up
T3842 737-739 TO denotes to
T3843 740-747 JJ denotes 30-fold
T3844 748-752 IN denotes upon
T3845 753-756 NNP denotes TCR
T3846 757-767 NN denotes activation
T3847 768-771 CC denotes and
T3848 772-780 NN denotes addition
T3849 781-783 IN denotes of
T3850 784-789 NNP denotes TGF-β
T3851 789-790 . denotes .
T3852 791-794 CD denotes Th1
T3853 795-800 NNS denotes cells
T3854 801-807 VBD denotes showed
T3855 808-812 RB denotes only
T3856 813-814 DT denotes a
T3857 815-822 JJ denotes 10-fold
T3858 823-831 NN denotes increase
T3859 831-832 . denotes .
T3860 833-835 IN denotes In
T3861 836-844 NN denotes contrast
T3862 844-845 , denotes ,
T3863 846-849 JJ denotes Th2
T3864 850-855 NNS denotes cells
T3865 856-866 VBN denotes stimulated
T3866 867-872 IN denotes under
T3867 873-876 DT denotes the
T3868 877-881 JJ denotes same
T3869 882-892 NNS denotes conditions
T3870 893-896 VBD denotes did
T3871 897-900 RB denotes not
T3872 901-909 VB denotes increase
T3873 910-915 CD denotes FOXP3
T3874 916-926 NN denotes expression
T3875 926-927 . denotes .
T3876 928-931 DT denotes The
T3877 932-934 IN denotes in
T3878 935-940 NN denotes vitro
T3879 941-950 VBD denotes generated
T3880 951-956 NNP denotes iTreg
T3881 957-962 NNS denotes cells
T3882 963-967 VBD denotes were
T3883 968-974 JJ denotes unable
T3884 975-977 TO denotes to
T3885 978-985 JJ denotes further
T3886 986-997 JJ denotes up-regulate
T3887 998-1003 NNP denotes FOXP3
T3888 1003-1004 , denotes ,
T3889 1005-1010 WDT denotes which
T3890 1011-1014 VBD denotes was
T3891 1015-1022 RB denotes already
T3892 1023-1025 IN denotes at
T3893 1026-1030 JJ denotes high
T3894 1031-1037 NNS denotes levels
T3895 1038-1043 IN denotes under
T3896 1044-1047 DT denotes the
T3897 1048-1055 NN denotes resting
T3898 1056-1066 NNS denotes conditions
T3899 1067-1068 -LRB- denotes (
T3900 1068-1074 NN denotes Figure
T3901 1075-1077 NN denotes 1B
T3902 1077-1078 , denotes ,
T3903 1079-1084 JJ denotes right
T3904 1085-1090 NN denotes panel
T3905 1090-1091 -RRB- denotes )
T3906 1091-1092 . denotes .
T3907 1103-1106 CD denotes Th2
T3908 1107-1112 NNS denotes Cells
T3909 1683-1686 VBP denotes are
T3910 1687-1692 VBN denotes known
T3911 1693-1695 TO denotes to
T3912 1696-1703 VB denotes produce
T3913 1704-1708 NN denotes IL-4
T3914 1709-1713 IN denotes upon
T3915 1714-1724 NN denotes activation
T3916 1724-1725 , denotes ,
T3917 1726-1731 WDT denotes which
T3918 1732-1735 MD denotes may
T3919 1736-1744 VB denotes interact
T3920 1745-1749 IN denotes with
T3921 1750-1755 JJ denotes TGF-β
T3922 1756-1765 VBG denotes signaling
T3923 1766-1769 CC denotes and
T3924 1770-1774 RB denotes thus
T3925 1775-1782 VB denotes prevent
T3926 1783-1788 CD denotes FOXP3
T3927 1789-1798 NN denotes induction
T3928 1798-1799 . denotes .
T3929 1800-1807 RB denotes However
T3930 1807-1808 , denotes ,
T3931 1809-1812 DT denotes the
T3932 1813-1827 NN denotes neutralization
T3933 1828-1830 IN denotes of
T3934 1831-1835 NN denotes IL-4
T3935 1836-1840 IN denotes with
T3936 1841-1842 DT denotes a
T3937 1843-1851 VBG denotes blocking
T3938 1852-1856 NN denotes IL-4
T3939 1857-1865 NN denotes antibody
T3940 1866-1869 VBD denotes did
T3941 1870-1873 RB denotes not
T3942 1874-1880 NN denotes rescue
T3943 1881-1886 CD denotes FOXP3
T3944 1887-1897 NN denotes expression
T3945 1898-1900 IN denotes in
T3946 1901-1904 DT denotes the
T3947 1905-1919 JJ denotes differentiated
T3948 1920-1923 JJ denotes Th2
T3949 1924-1929 NNS denotes cells
T3950 1930-1931 -LRB- denotes (
T3951 1931-1942 JJ denotes unpublished
T3952 1943-1947 NNS denotes data
T3953 1947-1948 -RRB- denotes )
T3954 1948-1949 . denotes .
T3955 1950-1955 DT denotes These
T3956 1956-1960 NNS denotes data
T3957 1961-1973 VBD denotes demonstrated
T3958 1974-1978 IN denotes that
T3959 1979-1982 JJ denotes Th2
T3960 1983-1988 NNS denotes cells
T3961 1989-1993 VBP denotes have
T3962 1994-1995 DT denotes a
T3963 1996-2003 JJ denotes limited
T3964 2004-2012 NN denotes capacity
T3965 2013-2015 TO denotes to
T3966 2016-2023 VB denotes express
T3967 2024-2029 NNP denotes FOXP3
T3968 2030-2031 -LRB- denotes (
T3969 2031-2037 NNP denotes Figure
T3970 2038-2040 NNP denotes 1B
T3971 2040-2041 -RRB- denotes )
T3972 2041-2042 . denotes .
T3973 2043-2046 DT denotes The
T3974 2047-2056 NN denotes inability
T3975 2057-2059 IN denotes of
T3976 2060-2063 JJ denotes Th2
T3977 2064-2069 NNS denotes cells
T3978 2070-2072 TO denotes to
T3979 2073-2080 VB denotes express
T3980 2081-2086 CD denotes FOXP3
T3981 2087-2090 VBD denotes was
T3982 2091-2095 RB denotes also
T3983 2096-2106 VBN denotes documented
T3984 2107-2109 IN denotes at
T3985 2110-2113 DT denotes the
T3986 2114-2125 JJ denotes single-cell
T3987 2126-2131 NN denotes level
T3988 2131-2132 , denotes ,
T3989 2133-2143 VBG denotes confirming
T3990 2144-2148 IN denotes that
T3991 2149-2152 JJ denotes Th2
T3992 2153-2158 NNS denotes cells
T3993 2159-2163 VBP denotes lack
T3994 2164-2169 CD denotes FOXP3
T3995 2170-2180 NN denotes expression
T3996 2181-2182 -LRB- denotes (
T3997 2182-2188 NN denotes Figure
T3998 2189-2191 NN denotes 2A
T3999 2191-2192 -RRB- denotes )
T4000 2192-2193 . denotes .
T4001 2194-2198 RB denotes Only
T4002 2199-2204 JJ denotes iTreg
T4003 2205-2210 NNS denotes cells
T4004 2211-2220 VBD denotes expressed
T4005 2221-2226 CD denotes FOXP3
T4006 2227-2229 IN denotes in
T4007 2230-2237 VBG denotes resting
T4008 2238-2248 NNS denotes conditions
T4009 2248-2249 . denotes .
T4010 2250-2263 RB denotes Interestingly
T4011 2263-2264 , denotes ,
T4012 2265-2267 PRP denotes we
T4013 2268-2276 VBD denotes observed
T4014 2277-2281 IN denotes that
T4015 2282-2289 VBG denotes resting
T4016 2290-2295 NNP denotes iTreg
T4017 2296-2301 NNS denotes cells
T4018 2302-2309 VBP denotes express
T4019 2310-2315 CD denotes FOXP3
T4020 2316-2319 CC denotes but
T4021 2320-2324 VB denotes show
T4022 2325-2328 JJ denotes low
T4023 2329-2333 NNS denotes CD25
T4024 2334-2341 VBP denotes surface
T4025 2342-2352 NN denotes expression
T4026 2352-2353 . denotes .
T4027 2354-2362 VBN denotes Repeated
T4028 2363-2371 NN denotes exposure
T4029 2372-2374 TO denotes to
T4030 2375-2380 NNP denotes TGF-β
T4031 2381-2384 VBD denotes did
T4032 2385-2388 RB denotes not
T4033 2389-2396 JJ denotes further
T4034 2397-2405 NN denotes increase
T4035 2406-2409 DT denotes the
T4036 2410-2415 CD denotes FOXP3
T4037 2416-2426 NN denotes expression
T4038 2427-2429 IN denotes in
T4039 2430-2433 DT denotes the
T4040 2434-2439 NNP denotes iTreg
T4041 2440-2447 NN denotes lineage
T4042 2448-2451 CC denotes but
T4043 2452-2463 RB denotes transiently
T4044 2464-2471 VBD denotes induced
T4045 2472-2477 CD denotes FOXP3
T4046 2478-2488 NN denotes expression
T4047 2489-2491 IN denotes in
T4048 2492-2495 JJ denotes Th1
T4049 2496-2501 NNS denotes cells
T4050 2501-2502 . denotes .
T4051 2503-2512 RB denotes Naturally
T4052 2513-2522 VBG denotes occurring
T4053 2523-2526 JJ denotes Th2
T4054 2527-2532 NNS denotes cells
T4055 2533-2537 JJ denotes such
T4056 2538-2540 IN denotes as
T4057 2541-2546 NNP denotes CRTH2
T4058 2546-2547 NNP denotes +
T4059 2548-2549 NNP denotes T
T4060 2550-2555 NNS denotes cells
T4061 2555-2556 , denotes ,
T4062 2557-2558 NNP denotes T
T4063 2559-2564 NNS denotes cells
T4064 2565-2573 VBD denotes isolated
T4065 2574-2583 VBG denotes according
T4066 2584-2586 TO denotes to
T4067 2587-2592 PRP$ denotes their
T4068 2593-2597 NN denotes IL-4
T4069 2598-2607 NN denotes secretion
T4070 2607-2608 , denotes ,
T4071 2609-2611 CC denotes or
T4072 2612-2614 DT denotes an
T4073 2615-2619 NN denotes IL-4
T4074 2620-2629 VBG denotes producing
T4075 2630-2631 NNP denotes T
T4076 2632-2636 NN denotes cell
T4077 2637-2642 NN denotes clone
T4078 2643-2644 -LRB- denotes (
T4079 2644-2647 CD denotes BR8
T4080 2647-2648 -RRB- denotes )
T4081 2649-2653 VBD denotes were
T4082 2654-2658 RB denotes also
T4083 2659-2666 VBG denotes lacking
T4084 2667-2672 CD denotes FOXP3
T4085 2673-2683 NN denotes expression
T4086 2684-2685 -LRB- denotes (
T4087 2685-2691 NN denotes Figure
T4088 2692-2694 NN denotes 2B
T4089 2694-2695 -RRB- denotes )
T4090 2695-2696 . denotes .
T4091 2697-2708 RB denotes Furthermore
T4092 2709-2714 JJ denotes TGF-β
T4093 2715-2723 VBD denotes mediated
T4094 2724-2729 CD denotes FOXP3
T4095 2730-2739 NN denotes induction
T4096 2740-2746 VBD denotes failed
T4097 2747-2749 IN denotes in
T4098 2750-2755 DT denotes these
T4099 2756-2761 NNS denotes cells
T4100 2762-2764 IN denotes in
T4101 2765-2773 NN denotes contrast
T4102 2774-2776 TO denotes to
T4103 2777-2780 DT denotes the
T4104 2781-2786 JJ denotes naive
T4105 2787-2788 NNP denotes T
T4106 2789-2794 NNS denotes cells
T4107 2795-2796 -LRB- denotes (
T4108 2796-2802 NN denotes Figure
T4109 2803-2805 NN denotes 2B
T4110 2805-2806 -RRB- denotes )
T4111 2806-2807 . denotes .
T4112 2808-2815 IN denotes Because
T4113 2816-2820 NN denotes IL-4
T4114 2821-2823 VBZ denotes is
T4115 2824-2827 DT denotes the
T4116 2828-2831 JJ denotes key
T4117 2832-2835 JJ denotes Th2
T4118 2836-2844 NN denotes cytokine
T4119 2844-2845 , denotes ,
T4120 2846-2849 DT denotes the
T4121 2850-2860 NN denotes expression
T4122 2861-2863 IN denotes of
T4123 2864-2868 NN denotes IL-4
T4124 2869-2872 CC denotes and
T4125 2873-2878 CD denotes FOXP3
T4126 2879-2881 IN denotes in
T4127 2882-2889 RB denotes freshly
T4128 2890-2898 VBN denotes isolated
T4129 2899-2902 NNP denotes CD4
T4130 2902-2903 CD denotes +
T4131 2904-2905 NNP denotes T
T4132 2906-2911 NNS denotes cells
T4133 2912-2915 VBD denotes was
T4134 2916-2924 VBN denotes analyzed
T4135 2925-2927 IN denotes by
T4136 2928-2940 NN denotes fluorescence
T4137 2941-2950 VBN denotes activated
T4138 2951-2955 NN denotes cell
T4139 2956-2963 VBG denotes sorting
T4140 2964-2965 -LRB- denotes (
T4141 2965-2969 NNP denotes FACS
T4142 2969-2970 -RRB- denotes )
T4143 2970-2971 . denotes .
T4144 2972-2976 NN denotes IL-4
T4145 2977-2987 VBG denotes expressing
T4146 2988-2993 NNS denotes cells
T4147 2994-2998 VBD denotes were
T4148 2999-3003 RBS denotes most
T4149 3004-3012 JJ denotes abundant
T4150 3013-3018 IN denotes among
T4151 3019-3025 CD denotes CD45RO
T4152 3025-3026 CD denotes +
T4153 3026-3030 NNS denotes CD25
T4154 3032-3037 NNS denotes cells
T4155 3037-3038 , denotes ,
T4156 3039-3044 WDT denotes which
T4157 3045-3048 VBD denotes did
T4158 3049-3052 RB denotes not
T4159 3053-3063 JJ denotes co-express
T4160 3064-3069 NNP denotes FOXP3
T4161 3070-3071 -LRB- denotes (
T4162 3071-3077 NNP denotes Figure
T4163 3078-3080 NNP denotes 3A
T4164 3080-3081 , denotes ,
T4165 3082-3086 VBD denotes left
T4166 3087-3092 NN denotes panel
T4167 3092-3093 -RRB- denotes )
T4168 3093-3094 . denotes .
T4169 3095-3097 IN denotes In
T4170 3098-3106 NN denotes contrast
T4171 3106-3107 , denotes ,
T4172 3108-3114 NNP denotes CD45RO
T4173 3114-3115 NNP denotes +
T4174 3115-3119 NNP denotes CD25
T4175 3119-3120 VBD denotes +
T4176 3121-3126 NNS denotes cells
T4177 3127-3137 RB denotes abundantly
T4178 3138-3147 VBD denotes expressed
T4179 3148-3153 CD denotes FOXP3
T4180 3153-3154 , denotes ,
T4181 3155-3160 IN denotes while
T4182 3161-3168 VBG denotes lacking
T4183 3169-3173 NN denotes IL-4
T4184 3174-3175 -LRB- denotes (
T4185 3175-3181 NNP denotes Figure
T4186 3182-3184 NNP denotes 3A
T4187 3184-3185 , denotes ,
T4188 3186-3191 JJ denotes right
T4189 3192-3197 NN denotes panel
T4190 3197-3198 -RRB- denotes )
T4191 3198-3199 . denotes .
T4192 3200-3202 IN denotes As
T4193 3203-3208 VBN denotes shown
T4194 3209-3211 IN denotes in
T4195 3212-3218 NN denotes Figure
T4196 3219-3221 NN denotes 3B
T4197 3221-3222 , denotes ,
T4198 3223-3226 DT denotes the
T4199 3227-3236 NN denotes frequency
T4200 3237-3239 IN denotes of
T4201 3240-3243 DT denotes the
T4202 3244-3248 NN denotes IL-4
T4203 3248-3249 NN denotes +
T4204 3250-3255 NNS denotes cells
T4205 3256-3259 VBD denotes was
T4206 3260-3266 RB denotes always
T4207 3267-3272 IN denotes below
T4208 3273-3274 CD denotes 1
T4209 3274-3275 NN denotes %
T4210 3276-3278 IN denotes in
T4211 3279-3282 DT denotes the
T4212 3283-3288 CD denotes FOXP3
T4213 3288-3289 NN denotes +
T4214 3290-3295 NNS denotes cells
T4215 3296-3301 RB denotes close
T4216 3302-3304 TO denotes to
T4217 3305-3308 DT denotes the
T4218 3309-3319 NN denotes background
T4219 3319-3320 . denotes .
T4220 3321-3324 DT denotes The
T4221 3325-3329 NN denotes IL-4
T4222 3329-3330 NN denotes +
T4223 3331-3336 NNS denotes cells
T4224 3337-3341 VBD denotes were
T4225 3342-3350 VBN denotes confined
T4226 3351-3353 TO denotes to
T4227 3354-3357 DT denotes the
T4228 3358-3363 CD denotes FOXP3
T4229 3365-3370 NNS denotes cells
T4230 3370-3371 , denotes ,
T4231 3372-3374 IN denotes as
T4232 3375-3380 VBN denotes shown
T4233 3381-3384 IN denotes for
T4234 3385-3388 DT denotes the
T4235 3389-3395 NNP denotes CD45RO
T4236 3395-3396 NNP denotes +
T4237 3396-3400 NNP denotes CD25
T4238 3401-3402 , denotes ,
T4239 3403-3409 NNP denotes CD45RO
T4240 3409-3410 NNP denotes +
T4241 3410-3414 NNP denotes CD25
T4242 3414-3415 NNP denotes +
T4243 3415-3416 , denotes ,
T4244 3417-3420 CC denotes and
T4245 3421-3427 NNP denotes CD45RO
T4246 3427-3428 NNP denotes +
T4247 3428-3432 NNP denotes CD25
T4248 3432-3433 RB denotes +
T4249 3433-3437 JJ denotes high
T4250 3438-3443 NNS denotes cells
T4251 3444-3445 -LRB- denotes (
T4252 3445-3451 NN denotes Figure
T4253 3452-3454 NN denotes 3B
T4254 3454-3455 -RRB- denotes )
T4255 3455-3456 . denotes .
T4256 3457-3459 IN denotes In
T4257 3460-3468 NN denotes addition
T4258 3468-3469 , denotes ,
T4259 3470-3477 CC denotes neither
T4260 3478-3481 DT denotes the
T4261 3482-3485 JJ denotes Th2
T4262 3486-3491 NN denotes clone
T4263 3492-3493 -LRB- denotes (
T4264 3493-3496 CD denotes BR8
T4265 3496-3497 -RRB- denotes )
T4266 3498-3501 CC denotes nor
T4267 3502-3507 JJ denotes CRTH2
T4268 3508-3513 NNS denotes cells
T4269 3514-3527 RB denotes significantly
T4270 3528-3537 VBD denotes expressed
T4271 3538-3543 NNP denotes FOXP3
T4272 3544-3545 -LRB- denotes (
T4273 3545-3551 NNP denotes Figure
T4274 3552-3554 NNP denotes 3C
T4275 3554-3555 -RRB- denotes )
T4276 3555-3556 . denotes .
T4277 3557-3562 NNS denotes Cells
T4278 3563-3571 VBD denotes enriched
T4279 3572-3575 IN denotes for
T4280 3576-3581 PRP$ denotes their
T4281 3582-3586 NN denotes IL-4
T4282 3587-3596 NN denotes secretion
T4283 3597-3602 VBG denotes using
T4284 3603-3606 DT denotes the
T4285 3607-3615 JJ denotes magnetic
T4286 3616-3620 NN denotes cell
T4287 3621-3630 NN denotes isolation
T4288 3631-3641 NN denotes technology
T4289 3642-3651 VBD denotes contained
T4290 3652-3656 DT denotes some
T4291 3657-3673 JJ denotes FOXP3-expressing
T4292 3674-3679 NNS denotes cells
T4293 3679-3680 , denotes ,
T4294 3681-3684 CC denotes but
T4295 3685-3696 RB denotes importantly
T4296 3696-3697 , denotes ,
T4297 3698-3701 DT denotes the
T4298 3702-3712 NN denotes expression
T4299 3713-3716 VBD denotes did
T4300 3717-3720 RB denotes not
T4301 3721-3728 VB denotes overlap
T4302 3728-3729 . denotes .
T4303 3730-3735 VBN denotes Taken
T4304 3736-3744 RB denotes together
T4305 3744-3745 , denotes ,
T4306 3746-3751 DT denotes these
T4307 3752-3756 NNS denotes data
T4308 3757-3765 VBP denotes indicate
T4309 3766-3770 IN denotes that
T4310 3771-3776 CD denotes FOXP3
T4311 3777-3780 VBD denotes was
T4312 3781-3784 RB denotes not
T4313 3785-3794 VBN denotes expressed
T4314 3795-3797 IN denotes by
T4315 3798-3801 JJ denotes Th2
T4316 3802-3807 NNS denotes cells
T4317 3808-3811 CC denotes and
T4318 3812-3815 VBD denotes was
T4319 3816-3819 RB denotes not
T4320 3820-3829 JJ denotes inducible
T4321 3830-3832 IN denotes in
T4322 3833-3838 DT denotes those
T4323 3839-3844 NNS denotes cells
T4324 3844-3845 . denotes .
T23591 1103-1106 CD denotes Th2
T23592 1107-1112 NNP denotes Cells
T23593 1113-1116 MD denotes Can
T23594 1116-1119 RB denotes not
T23595 1120-1126 VB denotes Induce
T23596 1127-1132 NNP denotes FOXP3
T23597 1133-1143 NNP denotes Expression
T23598 1144-1145 -LRB- denotes (
T23599 1145-1146 NNP denotes A
T23600 1146-1147 -RRB- denotes )
T23601 1148-1153 NNP denotes Human
T23602 1154-1155 NNP denotes T
T23603 1156-1161 NNS denotes cells
T23604 1162-1166 VBD denotes were
T23605 1167-1176 VBN denotes activated
T23606 1177-1181 IN denotes with
T23607 1182-1193 JJ denotes plate-bound
T23608 1194-1202 JJ denotes anti-CD3
T23609 1202-1203 NN denotes /
T23610 1203-1207 CD denotes CD28
T23611 1208-1212 IN denotes with
T23612 1213-1215 CC denotes or
T23613 1216-1223 IN denotes without
T23614 1224-1229 NNP denotes TGF-β
T23615 1230-1232 IN denotes as
T23616 1233-1242 VBN denotes indicated
T23617 1243-1245 IN denotes on
T23618 1246-1249 DT denotes the
T23619 1250-1256 NNS denotes x-axis
T23620 1257-1259 IN denotes of
T23621 1260-1261 -LRB- denotes (
T23622 1261-1262 NNP denotes B
T23623 1262-1263 -RRB- denotes )
T23624 1263-1264 . denotes .
T23625 1265-1270 NNS denotes Cells
T23626 1271-1275 VBD denotes were
T23627 1276-1285 VBN denotes harvested
T23628 1286-1291 IN denotes after
T23629 1292-1293 CD denotes 5
T23630 1294-1298 NNS denotes days
T23631 1299-1302 CC denotes and
T23632 1303-1308 CD denotes FOXP3
T23633 1309-1313 NNP denotes mRNA
T23634 1314-1317 VBD denotes was
T23635 1318-1328 VBN denotes quantified
T23636 1329-1331 IN denotes by
T23637 1332-1341 JJ denotes real-time
T23638 1342-1345 NNP denotes PCR
T23639 1345-1346 . denotes .
T23640 1347-1351 NNS denotes Bars
T23641 1352-1356 VBP denotes show
T23642 1357-1360 DT denotes the
T23643 1361-1365 JJ denotes mean
T23644 1366-1367 NN denotes ±
T23645 1368-1370 NNP denotes SD
T23646 1371-1373 IN denotes of
T23647 1374-1375 CD denotes 4
T23648 1376-1387 JJ denotes independent
T23649 1388-1399 NNS denotes experiments
T23650 1399-1400 . denotes .
T23651 1401-1402 -LRB- denotes (
T23652 1402-1403 NNP denotes B
T23653 1403-1404 -RRB- denotes )
T23654 1405-1407 IN denotes In
T23655 1408-1413 NN denotes vitro
T23656 1414-1428 VBN denotes differentiated
T23657 1429-1432 NNP denotes Th1
T23658 1432-1433 , denotes ,
T23659 1434-1437 NNP denotes Th2
T23660 1437-1438 , denotes ,
T23661 1439-1441 CC denotes or
T23662 1442-1447 NNP denotes iTreg
T23663 1448-1453 NNS denotes cells
T23664 1454-1458 VBD denotes were
T23665 1459-1468 VBN denotes activated
T23666 1469-1473 IN denotes with
T23667 1474-1482 JJ denotes anti-CD3
T23668 1482-1483 NN denotes /
T23669 1483-1487 NNP denotes CD28
T23670 1487-1488 , denotes ,
T23671 1489-1494 NNP denotes TGF-β
T23672 1494-1495 , denotes ,
T23673 1496-1498 CC denotes or
T23674 1499-1508 JJ denotes anti-IL-4
T23675 1509-1511 IN denotes as
T23676 1512-1521 VBN denotes indicated
T23677 1521-1522 . denotes .
T23678 1523-1526 DT denotes The
T23679 1527-1536 NN denotes phenotype
T23680 1537-1539 IN denotes of
T23681 1540-1545 DT denotes these
T23682 1546-1551 NNS denotes cells
T23683 1552-1555 VBD denotes was
T23684 1556-1565 VBN denotes confirmed
T23685 1566-1568 IN denotes by
T23686 1569-1573 NNP denotes FACS
T23687 1574-1577 CC denotes and
T23688 1578-1591 NN denotes proliferation
T23689 1592-1600 NN denotes analysis
T23690 1601-1602 -LRB- denotes (
T23691 1602-1608 NN denotes Figure
T23692 1609-1611 CD denotes S1
T23693 1611-1612 -RRB- denotes )
T23694 1612-1613 . denotes .
T23695 1614-1618 NNS denotes Bars
T23696 1619-1623 VBP denotes show
T23697 1624-1627 DT denotes the
T23698 1628-1632 JJ denotes mean
T23699 1633-1634 NN denotes ±
T23700 1635-1637 NNP denotes SD
T23701 1638-1640 IN denotes of
T23702 1641-1645 CD denotes four
T23703 1646-1657 JJ denotes independent
T23704 1658-1669 NNS denotes experiments
T23705 1669-1670 . denotes .
T23907 3856-3859 CD denotes Th2
T23908 3860-3865 NNS denotes Cells
T23909 3866-3868 VBP denotes Do
T23910 3869-3872 RB denotes Not
T23911 3873-3880 NNP denotes Express
T23912 3881-3886 NNP denotes FOXP3
T23913 3887-3888 -LRB- denotes (
T23914 3888-3889 NNP denotes A
T23915 3889-3890 -RRB- denotes )
T23916 3891-3904 NNP denotes Intracellular
T23917 3905-3909 NNP denotes FACS
T23918 3910-3918 NN denotes analysis
T23919 3919-3921 IN denotes of
T23920 3922-3927 CD denotes FOXP3
T23921 3928-3938 NN denotes expression
T23922 3939-3941 IN denotes in
T23923 3942-3945 NNP denotes Th1
T23924 3945-3946 , denotes ,
T23925 3947-3950 NNP denotes Th2
T23926 3950-3951 , denotes ,
T23927 3952-3954 CC denotes or
T23928 3955-3975 JJ denotes iTreg-differentiated
T23929 3976-3981 NNS denotes cells
T23930 3982-3983 -LRB- denotes (
T23931 3983-3986 CD denotes two
T23932 3987-3993 NNS denotes rounds
T23933 3993-3994 , denotes ,
T23934 3995-4004 NN denotes phenotype
T23935 4005-4008 VBP denotes see
T23936 4009-4015 NN denotes Figure
T23937 4016-4018 CD denotes S1
T23938 4018-4019 -RRB- denotes )
T23939 4019-4020 , denotes ,
T23940 4021-4027 VBD denotes rested
T23941 4028-4030 CC denotes or
T23942 4031-4040 VBD denotes activated
T23943 4040-4041 , denotes ,
T23944 4042-4046 IN denotes with
T23945 4047-4049 CC denotes or
T23946 4050-4057 IN denotes without
T23947 4058-4063 NNP denotes TGF-β
T23948 4063-4064 . denotes .
T23949 4065-4070 CD denotes FOXP3
T23950 4071-4081 NN denotes expression
T23951 4082-4085 VBD denotes was
T23952 4086-4094 VBN denotes measured
T23953 4095-4100 IN denotes after
T23954 4101-4102 CD denotes 5
T23955 4103-4104 LS denotes d
T23956 4105-4107 IN denotes in
T23957 4108-4115 NN denotes culture
T23958 4115-4116 . denotes .
T23959 4117-4120 DT denotes The
T23960 4121-4124 VBP denotes dot
T23961 4125-4130 NNS denotes blots
T23962 4131-4134 VBP denotes are
T23963 4135-4149 NN denotes representative
T23964 4150-4152 IN denotes of
T23965 4153-4158 CD denotes three
T23966 4159-4170 JJ denotes independent
T23967 4171-4182 NNS denotes experiments
T23968 4182-4183 . denotes .
T23969 4184-4185 -LRB- denotes (
T23970 4185-4186 NNP denotes B
T23971 4186-4187 -RRB- denotes )
T23972 4188-4193 VBZ denotes Shows
T23973 4194-4197 DT denotes the
T23974 4198-4202 JJ denotes same
T23975 4203-4215 JJ denotes experimental
T23976 4216-4221 NN denotes setup
T23977 4221-4222 , denotes ,
T23978 4223-4226 CC denotes but
T23979 4227-4236 RB denotes naturally
T23980 4237-4246 VBG denotes occurring
T23981 4247-4250 JJ denotes Th2
T23982 4251-4256 NNS denotes cells
T23983 4257-4261 VBD denotes were
T23984 4262-4270 VBN denotes analyzed
T23985 4270-4271 . denotes .
T23986 4272-4276 NNS denotes Data
T23987 4277-4280 VBP denotes are
T23988 4281-4295 NN denotes representative
T23989 4296-4298 IN denotes of
T23990 4299-4304 CD denotes three
T23991 4305-4316 JJ denotes independent
T23992 4317-4328 NNS denotes experiments
T23993 4328-4329 . denotes .
T24303 4340-4343 SYM denotes Th2
T24304 4343-4344 : denotes -
T24305 4345-4347 CC denotes or
T24306 4348-4352 NN denotes IL-4
T24307 4353-4362 NNP denotes Producing
T24308 4363-4368 NNP denotes Cells
T24309 4369-4373 NNP denotes Lack
T24310 4374-4379 NNP denotes FOXP3
T24311 4380-4381 -LRB- denotes (
T24312 4381-4382 NNP denotes A
T24313 4382-4383 -RRB- denotes )
T24314 4384-4388 NNP denotes FACS
T24315 4389-4397 NN denotes analysis
T24316 4398-4400 IN denotes of
T24317 4401-4414 JJ denotes intracellular
T24318 4415-4420 CD denotes FOXP3
T24319 4421-4424 CC denotes and
T24320 4425-4429 NN denotes IL-4
T24321 4430-4440 NN denotes expression
T24322 4441-4450 VBG denotes following
T24323 4451-4464 NNP denotes PMA/Ionomycin
T24324 4465-4476 NN denotes stimulation
T24325 4476-4477 . denotes .
T24326 4478-4481 CD denotes CD4
T24327 4481-4482 CD denotes +
T24328 4483-4484 NNP denotes T
T24329 4485-4490 NNS denotes cells
T24330 4491-4495 VBD denotes were
T24331 4496-4501 VBN denotes gated
T24332 4502-4504 IN denotes on
T24333 4505-4508 DT denotes the
T24334 4509-4514 NN denotes basis
T24335 4515-4517 IN denotes of
T24336 4518-4524 CD denotes CD45RO
T24337 4525-4528 CC denotes and
T24338 4529-4533 CD denotes CD25
T24339 4534-4541 NN denotes surface
T24340 4542-4552 NN denotes expression
T24341 4553-4554 -LRB- denotes (
T24342 4554-4559 JJ denotes upper
T24343 4560-4565 NN denotes panel
T24344 4565-4566 -RRB- denotes )
T24345 4566-4567 , denotes ,
T24346 4568-4571 CC denotes and
T24347 4572-4577 VBD denotes gated
T24348 4578-4583 NNS denotes cells
T24349 4584-4587 VBP denotes are
T24350 4588-4593 VBN denotes shown
T24351 4594-4599 IN denotes below
T24352 4600-4603 IN denotes for
T24353 4604-4607 DT denotes the
T24354 4608-4614 NNP denotes CD45RO
T24355 4614-4615 NNP denotes +
T24356 4615-4619 NNP denotes CD25
T24357 4619-4620 NNP denotes
T24358 4621-4622 -LRB- denotes (
T24359 4622-4623 NNP denotes A
T24360 4623-4624 , denotes ,
T24361 4625-4629 VBD denotes left
T24362 4630-4635 NN denotes panel
T24363 4635-4636 -RRB- denotes )
T24364 4636-4637 , denotes ,
T24365 4638-4641 DT denotes the
T24366 4642-4648 NNP denotes CD45RO
T24367 4648-4649 NNP denotes +
T24368 4649-4653 NNP denotes CD25
T24369 4653-4654 NNP denotes +
T24370 4655-4656 -LRB- denotes (
T24371 4656-4661 JJ denotes right
T24372 4662-4667 NN denotes panel
T24373 4667-4668 -RRB- denotes )
T24374 4668-4669 , denotes ,
T24375 4670-4673 CC denotes and
T24376 4674-4677 DT denotes the
T24377 4678-4684 NNP denotes CD45RO
T24378 4684-4685 NNP denotes
T24379 4685-4689 NNP denotes CD25
T24380 4689-4690 VBD denotes
T24381 4691-4698 NNS denotes subsets
T24382 4699-4700 -LRB- denotes (
T24383 4700-4707 JJ denotes central
T24384 4708-4713 NN denotes panel
T24385 4713-4714 -RRB- denotes )
T24386 4714-4715 . denotes .
T24387 4716-4717 DT denotes A
T24388 4718-4729 JJ denotes statistical
T24389 4730-4738 NN denotes analysis
T24390 4739-4741 IN denotes of
T24391 4742-4747 CD denotes eight
T24392 4748-4759 JJ denotes independent
T24393 4760-4766 NNS denotes donors
T24394 4767-4772 IN denotes after
T24395 4773-4784 NN denotes subtraction
T24396 4785-4787 IN denotes of
T24397 4788-4791 DT denotes the
T24398 4792-4799 NN denotes isotype
T24399 4800-4807 NN denotes control
T24400 4808-4811 VBP denotes are
T24401 4812-4817 VBN denotes shown
T24402 4818-4820 IN denotes in
T24403 4821-4822 -LRB- denotes (
T24404 4822-4823 NNP denotes B
T24405 4823-4824 -RRB- denotes )
T24406 4824-4825 . denotes .
T24407 4826-4829 DT denotes The
T24408 4830-4836 JJ denotes dotted
T24409 4837-4841 JJ denotes gray
T24410 4842-4846 NN denotes line
T24411 4847-4856 VBZ denotes indicates
T24412 4857-4860 DT denotes the
T24413 4861-4863 NNP denotes IC
T24414 4864-4874 NN denotes background
T24415 4875-4880 NN denotes level
T24416 4880-4881 . denotes .
T24417 4882-4885 DT denotes The
T24418 4886-4891 NN denotes error
T24419 4892-4896 NNS denotes bars
T24420 4897-4901 VBP denotes show
T24421 4902-4905 DT denotes the
T24422 4906-4911 NN denotes error
T24423 4912-4914 IN denotes of
T24424 4915-4918 DT denotes the
T24425 4919-4923 NN denotes mean
T24426 4923-4924 . denotes .
T24427 4925-4926 -LRB- denotes (
T24428 4926-4927 $ denotes C
T24429 4927-4928 -RRB- denotes )
T24430 4929-4938 RB denotes Similarly
T24431 4938-4939 , denotes ,
T24432 4940-4941 DT denotes a
T24433 4942-4945 JJ denotes Th2
T24434 4946-4951 NN denotes clone
T24435 4952-4953 -LRB- denotes (
T24436 4953-4956 CD denotes BR8
T24437 4956-4957 -RRB- denotes )
T24438 4957-4958 , denotes ,
T24439 4959-4964 NNP denotes CRTH2
T24440 4964-4965 NNP denotes +
T24441 4966-4969 NNP denotes Th2
T24442 4970-4975 NNS denotes cells
T24443 4975-4976 , denotes ,
T24444 4977-4991 JJ denotes IL-4-secreting
T24445 4992-4997 NNS denotes cells
T24446 4997-4998 , denotes ,
T24447 4999-5002 CC denotes and
T24448 5003-5009 NN denotes memory
T24449 5010-5011 NNP denotes T
T24450 5012-5017 NNS denotes cells
T24451 5018-5019 -LRB- denotes (
T24452 5019-5025 CD denotes CD45RO
T24453 5025-5026 -RRB- denotes )
T24454 5027-5031 VBD denotes were
T24455 5032-5039 VBN denotes stained
T24456 5040-5043 IN denotes for
T24457 5044-5049 CD denotes FOXP3
T24458 5050-5053 CC denotes and
T24459 5054-5058 NN denotes IL-4
T24460 5058-5059 . denotes .
T24461 5060-5064 NNS denotes Data
T24462 5065-5068 VBP denotes are
T24463 5069-5083 NN denotes representative
T24464 5084-5086 IN denotes of
T24465 5087-5092 CD denotes three
T24466 5093-5104 JJ denotes independent
T24467 5105-5116 NNS denotes experiments
T24468 5116-5117 . denotes .
R2960 T3688 T3689 nummod FOXP3,Induction
R2961 T3689 T3696 npadvmod Induction,assumed
R2962 T3690 T3689 prep in,Induction
R2963 T3691 T3693 compound T,Subsets
R2964 T3692 T3693 compound Cell,Subsets
R2965 T3693 T3690 pobj Subsets,in
R2966 T3694 T3696 nsubjpass It,assumed
R2967 T3695 T3696 auxpass is,assumed
R2968 T3696 T3696 ROOT assumed,assumed
R2969 T3697 T3702 mark that,induced
R2970 T3698 T3699 nummod FOXP3,expression
R2971 T3699 T3702 nsubjpass expression,induced
R2972 T3700 T3702 aux can,induced
R2973 T3701 T3702 auxpass be,induced
R2974 T3702 T3696 ccomp induced,assumed
R2975 T3703 T3702 prep in,induced
R2976 T3704 T3706 amod nonregulatory,cells
R2977 T3705 T3706 compound T,cells
R2978 T3706 T3703 pobj cells,in
R2979 T3707 T3706 punct ",",cells
R2980 T3708 T3709 nsubj which,is
R2981 T3709 T3702 advcl is,induced
R2982 T3710 T3712 det an,step
R2983 T3711 T3712 amod important,step
R2984 T3712 T3709 attr step,is
R2985 T3713 T3712 prep in,step
R2986 T3714 T3716 compound iTreg,differentiation
R2987 T3715 T3716 compound cell,differentiation
R2988 T3716 T3713 pobj differentiation,in
R2989 T3717 T3696 punct .,assumed
R2990 T3718 T3723 advmod However,known
R2991 T3719 T3723 punct ",",known
R2992 T3720 T3723 nsubjpass it,known
R2993 T3721 T3723 auxpass is,known
R2994 T3722 T3723 neg not,known
R2995 T3723 T3723 ROOT known,known
R2996 T3724 T3730 mark if,have
R2997 T3725 T3729 det all,cells
R2998 T3726 T3729 nummod CD4,cells
R2999 T3727 T3729 compound +,cells
R3000 T3728 T3729 compound T,cells
R3001 T3729 T3730 nsubj cells,have
R3002 T3730 T3723 advcl have,known
R3003 T3731 T3733 det the,capacity
R3004 T3732 T3733 amod same,capacity
R3005 T3733 T3730 dobj capacity,have
R3006 T3734 T3735 aux to,express
R3007 T3735 T3733 acl express,capacity
R3008 T3736 T3735 dobj FOXP3,express
R3009 T3737 T3723 punct .,known
R3010 T3738 T3739 aux To,investigate
R3011 T3739 T3764 advcl investigate,analyzed
R3012 T3740 T3744 mark whether,expressed
R3013 T3741 T3744 nsubjpass FOXP3,expressed
R3014 T3742 T3744 aux can,expressed
R3015 T3743 T3744 auxpass be,expressed
R3016 T3744 T3739 ccomp expressed,investigate
R3017 T3745 T3744 agent by,expressed
R3018 T3746 T3749 det any,subset
R3019 T3747 T3748 compound T,cell
R3020 T3748 T3749 compound cell,subset
R3021 T3749 T3745 pobj subset,by
R3022 T3750 T3744 cc or,expressed
R3023 T3751 T3754 mark if,restricted
R3024 T3752 T3754 nsubjpass expression,restricted
R3025 T3753 T3754 auxpass is,restricted
R3026 T3754 T3744 conj restricted,expressed
R3027 T3755 T3754 prep to,restricted
R3028 T3756 T3758 det a,lineage
R3029 T3757 T3758 amod distinct,lineage
R3030 T3758 T3755 pobj lineage,to
R3031 T3759 T3764 punct ",",analyzed
R3032 T3760 T3762 nummod FOXP3,expression
R3033 T3761 T3762 compound mRNA,expression
R3034 T3762 T3764 nsubjpass expression,analyzed
R3035 T3763 T3764 auxpass was,analyzed
R3036 T3764 T3811 ccomp analyzed,phenotype
R3037 T3765 T3764 prep in,analyzed
R3038 T3766 T3767 advmod freshly,isolated
R3039 T3767 T3769 amod isolated,cells
R3040 T3768 T3769 compound T,cells
R3041 T3769 T3765 pobj cells,in
R3042 T3770 T3771 amod such,as
R3043 T3771 T3769 prep as,cells
R3044 T3772 T3775 amod CD25-depleted,cells
R3045 T3773 T3775 compound CD4,cells
R3046 T3774 T3775 compound +,cells
R3047 T3775 T3771 pobj cells,as
R3048 T3776 T3764 punct ",",analyzed
R3049 T3777 T3778 compound CD45RA,+
R3050 T3778 T3779 nsubj +,naive
R3051 T3779 T3795 amod naive,cells
R3052 T3780 T3779 cc or,naive
R3053 T3781 T3785 nummod CD45RO,cells
R3054 T3782 T3785 amod +,cells
R3055 T3783 T3785 compound memory,cells
R3056 T3784 T3785 compound T,cells
R3057 T3785 T3779 conj cells,naive
R3058 T3786 T3787 punct (,Figure
R3059 T3787 T3785 appos Figure,cells
R3060 T3788 T3787 nummod 1A,Figure
R3061 T3789 T3787 punct ),Figure
R3062 T3790 T3787 punct ",",Figure
R3063 T3791 T3793 advmod as,as
R3064 T3792 T3793 advmod well,as
R3065 T3793 T3787 cc as,Figure
R3066 T3794 T3795 compound T,cells
R3067 T3795 T3811 dep cells,phenotype
R3068 T3796 T3795 acl driven,cells
R3069 T3797 T3796 prep in,driven
R3070 T3798 T3797 pobj vitro,in
R3071 T3799 T3798 prep toward,vitro
R3072 T3800 T3799 pobj Th1,toward
R3073 T3801 T3800 punct ",",Th1
R3074 T3802 T3800 conj Th2,Th1
R3075 T3803 T3802 punct ",",Th2
R3076 T3804 T3802 cc or,Th2
R3077 T3805 T3802 conj iTreg,Th2
R3078 T3806 T3802 conj phenotypes,Th2
R3079 T3807 T3808 punct (,Figure
R3080 T3808 T3795 appos Figure,cells
R3081 T3809 T3808 nummod 1B,Figure
R3082 T3810 T3811 punct ;,phenotype
R3083 T3811 T3811 ROOT phenotype,phenotype
R3084 T3812 T3811 prep on,phenotype
R3085 T3813 T3812 pobj Figure,on
R3086 T3814 T3813 nummod S1,Figure
R3087 T3815 T3811 punct ),phenotype
R3088 T3816 T3811 punct .,phenotype
R3089 T3817 T3820 det The,CD25
R3090 T3818 T3820 compound CD4,CD25
R3091 T3819 T3820 compound +,CD25
R3092 T3820 T3834 nsubj CD25,were
R3093 T3821 T3820 punct ",",CD25
R3094 T3822 T3823 compound CD45RA,+
R3095 T3823 T3820 appos +,CD25
R3096 T3824 T3823 punct ",",+
R3097 T3825 T3826 compound CD45RO,+
R3098 T3826 T3820 appos +,CD25
R3099 T3827 T3826 punct ",",+
R3100 T3828 T3826 cc and,+
R3101 T3829 T3833 compound CD4,CD25
R3102 T3830 T3833 compound +,CD25
R3103 T3831 T3833 compound CD45RO,CD25
R3104 T3832 T3833 compound +,CD25
R3105 T3833 T3826 conj CD25,+
R3106 T3834 T3834 ROOT were,were
R3107 T3835 T3834 acomp able,were
R3108 T3836 T3838 aux to,induce
R3109 T3837 T3838 advmod significantly,induce
R3110 T3838 T3835 xcomp induce,able
R3111 T3839 T3840 nummod FOXP3,mRNA
R3112 T3840 T3838 dobj mRNA,induce
R3113 T3841 T3838 cc up,induce
R3114 T3842 T3843 aux to,30-fold
R3115 T3843 T3838 xcomp 30-fold,induce
R3116 T3844 T3843 prep upon,30-fold
R3117 T3845 T3846 compound TCR,activation
R3118 T3846 T3844 pobj activation,upon
R3119 T3847 T3846 cc and,activation
R3120 T3848 T3846 conj addition,activation
R3121 T3849 T3848 prep of,addition
R3122 T3850 T3849 pobj TGF-β,of
R3123 T3851 T3834 punct .,were
R3124 T3852 T3853 nummod Th1,cells
R3125 T3853 T3854 nsubj cells,showed
R3126 T3854 T3854 ROOT showed,showed
R3127 T3855 T3858 advmod only,increase
R3128 T3856 T3858 det a,increase
R3129 T3858 T3854 dobj increase,showed
R3130 T3857 T3858 amod 10-fold,increase
R3131 T3859 T3854 punct .,showed
R3132 T3860 T3872 prep In,increase
R3133 T3898 T3895 pobj conditions,under
R3134 T3861 T3860 pobj contrast,In
R3135 T3862 T3872 punct ",",increase
R3136 T3863 T3864 amod Th2,cells
R3137 T3899 T3901 punct (,1B
R3138 T3864 T3872 nsubj cells,increase
R3139 T3865 T3864 acl stimulated,cells
R3140 T3866 T3865 prep under,stimulated
R3141 T3900 T3901 compound Figure,1B
R3142 T3867 T3869 det the,conditions
R3143 T3868 T3869 amod same,conditions
R3144 T3901 T3898 appos 1B,conditions
R3145 T3869 T3866 pobj conditions,under
R3146 T3870 T3872 aux did,increase
R3147 T3871 T3872 neg not,increase
R3148 T3872 T3872 ROOT increase,increase
R3149 T3902 T3904 punct ",",panel
R3150 T3873 T3874 nummod FOXP3,expression
R3151 T3874 T3872 dobj expression,increase
R3152 T3903 T3904 amod right,panel
R3153 T3875 T3872 punct .,increase
R3154 T3876 T3881 det The,cells
R3155 T3877 T3879 prep in,generated
R3156 T3904 T3901 appos panel,1B
R3157 T3878 T3877 pobj vitro,in
R3158 T3879 T3881 amod generated,cells
R3159 T3880 T3881 compound iTreg,cells
R3160 T3905 T3901 punct ),1B
R3161 T3881 T3882 nsubj cells,were
R3162 T3882 T3882 ROOT were,were
R3163 T3906 T3882 punct .,were
R3164 T3907 T3908 nummod Th2,Cells
R3165 T3883 T3882 acomp unable,were
R3166 T3884 T3885 aux to,further
R3167 T3885 T3883 xcomp further,unable
R3168 T3886 T3887 compound up-regulate,FOXP3
R3169 T3908 T3910 nsubjpass Cells,known
R3170 T3887 T3885 dobj FOXP3,further
R3171 T3888 T3887 punct ",",FOXP3
R3172 T3889 T3890 nsubj which,was
R3173 T3890 T3887 relcl was,FOXP3
R3174 T3909 T3910 auxpass are,known
R3175 T3891 T3890 advmod already,was
R3176 T3892 T3890 prep at,was
R3177 T3910 T3910 ROOT known,known
R3178 T3893 T3894 amod high,levels
R3179 T3894 T3892 pobj levels,at
R3180 T3895 T3890 prep under,was
R3181 T3911 T3912 aux to,produce
R3182 T3896 T3898 det the,conditions
R3183 T3897 T3898 amod resting,conditions
R3184 T3912 T3910 xcomp produce,known
R3185 T3913 T3912 dobj IL-4,produce
R3186 T3914 T3912 prep upon,produce
R3187 T3915 T3914 pobj activation,upon
R3188 T3916 T3915 punct ",",activation
R3189 T3917 T3919 nsubj which,interact
R3190 T3918 T3919 aux may,interact
R3191 T3995 T3993 dobj expression,lack
R3192 T3919 T3915 relcl interact,activation
R3193 T3996 T3998 punct (,2A
R3194 T3997 T3998 nmod Figure,2A
R3195 T3920 T3919 prep with,interact
R3196 T3998 T3995 appos 2A,expression
R3197 T3999 T3998 punct ),2A
R3198 T4000 T3983 punct .,documented
R3199 T3921 T3922 amod TGF-β,signaling
R3200 T4001 T4003 advmod Only,cells
R3201 T4002 T4003 amod iTreg,cells
R3202 T3922 T3920 pobj signaling,with
R3203 T4003 T4004 nsubj cells,expressed
R3204 T4004 T4004 ROOT expressed,expressed
R3205 T4005 T4004 dobj FOXP3,expressed
R3206 T3923 T3922 cc and,signaling
R3207 T4006 T4004 prep in,expressed
R3208 T4007 T4008 compound resting,conditions
R3209 T4008 T4006 pobj conditions,in
R3210 T4009 T4004 punct .,expressed
R3211 T3924 T3925 advmod thus,prevent
R3212 T4010 T4013 advmod Interestingly,observed
R3213 T4011 T4013 punct ",",observed
R3214 T4012 T4013 nsubj we,observed
R3215 T3925 T3919 conj prevent,interact
R3216 T4013 T4013 ROOT observed,observed
R3217 T4014 T4018 mark that,express
R3218 T4015 T4017 amod resting,cells
R3219 T4016 T4017 compound iTreg,cells
R3220 T4017 T4018 nsubj cells,express
R3221 T3926 T3927 nummod FOXP3,induction
R3222 T4018 T4013 ccomp express,observed
R3223 T4019 T4018 dobj FOXP3,express
R3224 T4020 T4018 cc but,express
R3225 T3927 T3925 dobj induction,prevent
R3226 T4021 T4018 conj show,express
R3227 T4022 T4023 amod low,CD25
R3228 T3928 T3910 punct .,known
R3229 T4023 T4024 compound CD25,surface
R3230 T4024 T4025 compound surface,expression
R3231 T4025 T4021 dobj expression,show
R3232 T4026 T4013 punct .,observed
R3233 T3929 T3942 advmod However,rescue
R3234 T4027 T4028 amod Repeated,exposure
R3235 T4028 T4034 nsubj exposure,increase
R3236 T4029 T4028 prep to,exposure
R3237 T3930 T3942 punct ",",rescue
R3238 T4030 T4029 pobj TGF-β,to
R3239 T4031 T4034 aux did,increase
R3240 T4032 T4033 neg not,further
R3241 T3931 T3932 det the,neutralization
R3242 T4033 T4034 advmod further,increase
R3243 T4034 T4034 ROOT increase,increase
R3244 T4035 T4037 det the,expression
R3245 T3932 T3942 nsubj neutralization,rescue
R3246 T4036 T4037 nummod FOXP3,expression
R3247 T4037 T4034 dobj expression,increase
R3248 T4038 T4037 prep in,expression
R3249 T4039 T4041 det the,lineage
R3250 T3933 T3932 prep of,neutralization
R3251 T4040 T4041 compound iTreg,lineage
R3252 T3934 T3933 pobj IL-4,of
R3253 T3935 T3932 prep with,neutralization
R3254 T4041 T4038 pobj lineage,in
R3255 T3936 T3939 det a,antibody
R3256 T4042 T4034 cc but,increase
R3257 T3937 T3939 amod blocking,antibody
R3258 T4043 T4044 advmod transiently,induced
R3259 T4044 T4034 conj induced,increase
R3260 T4045 T4046 nummod FOXP3,expression
R3261 T3938 T3939 compound IL-4,antibody
R3262 T4046 T4044 dobj expression,induced
R3263 T4047 T4044 prep in,induced
R3264 T4048 T4049 amod Th1,cells
R3265 T3939 T3935 pobj antibody,with
R3266 T4049 T4047 pobj cells,in
R3267 T4050 T4044 punct .,induced
R3268 T4051 T4052 advmod Naturally,occurring
R3269 T4052 T4064 advcl occurring,isolated
R3270 T4053 T4054 amod Th2,cells
R3271 T3940 T3942 aux did,rescue
R3272 T4054 T4052 dobj cells,occurring
R3273 T4055 T4056 amod such,as
R3274 T4056 T4054 prep as,cells
R3275 T3941 T3942 neg not,rescue
R3276 T4057 T4060 compound CRTH2,cells
R3277 T4058 T4060 compound +,cells
R3278 T4059 T4060 compound T,cells
R3279 T3942 T3942 ROOT rescue,rescue
R3280 T4060 T4056 pobj cells,as
R3281 T3943 T3944 nummod FOXP3,expression
R3282 T4061 T4064 punct ",",isolated
R3283 T4062 T4063 compound T,cells
R3284 T4063 T4064 nsubj cells,isolated
R3285 T4064 T4064 ROOT isolated,isolated
R3286 T3944 T3942 dobj expression,rescue
R3287 T4065 T4064 prep according,isolated
R3288 T4066 T4065 prep to,according
R3289 T4067 T4069 poss their,secretion
R3290 T3945 T3944 prep in,expression
R3291 T3946 T3949 det the,cells
R3292 T3947 T3949 amod differentiated,cells
R3293 T4068 T4069 compound IL-4,secretion
R3294 T3948 T3949 amod Th2,cells
R3295 T4069 T4066 pobj secretion,to
R3296 T3949 T3945 pobj cells,in
R3297 T4070 T4069 punct ",",secretion
R3298 T4071 T4069 cc or,secretion
R3299 T4072 T4073 det an,IL-4
R3300 T3950 T3952 punct (,data
R3301 T4073 T4069 conj IL-4,secretion
R3302 T4074 T4065 conj producing,according
R3303 T4075 T4077 compound T,clone
R3304 T3951 T3952 amod unpublished,data
R3305 T4076 T4077 compound cell,clone
R3306 T4077 T4074 dobj clone,producing
R3307 T4078 T4077 punct (,clone
R3308 T3952 T3949 appos data,cells
R3309 T4079 T4077 appos BR8,clone
R3310 T4080 T4077 punct ),clone
R3311 T4081 T4083 aux were,lacking
R3312 T3953 T3949 punct ),cells
R3313 T4082 T4083 advmod also,lacking
R3314 T4083 T4064 ccomp lacking,isolated
R3315 T4084 T4085 nummod FOXP3,expression
R3316 T4085 T4083 dobj expression,lacking
R3317 T4086 T4088 punct (,2B
R3318 T4087 T4088 compound Figure,2B
R3319 T4088 T4085 appos 2B,expression
R3320 T3954 T3942 punct .,rescue
R3321 T4089 T4064 punct ),isolated
R3322 T4090 T4064 punct .,isolated
R3323 T4091 T4092 advmod Furthermore,TGF-β
R3324 T3955 T3956 det These,data
R3325 T3956 T3957 nsubj data,demonstrated
R3326 T3957 T3957 ROOT demonstrated,demonstrated
R3327 T3958 T3961 mark that,have
R3328 T4092 T4093 nsubj TGF-β,mediated
R3329 T4093 T4093 ROOT mediated,mediated
R3330 T4094 T4095 nummod FOXP3,induction
R3331 T3959 T3960 amod Th2,cells
R3332 T4095 T4096 nsubj induction,failed
R3333 T4096 T4093 ccomp failed,mediated
R3334 T4097 T4096 prep in,failed
R3335 T3960 T3961 nsubj cells,have
R3336 T4098 T4099 det these,cells
R3337 T4099 T4097 pobj cells,in
R3338 T4100 T4096 prep in,failed
R3339 T3961 T3957 ccomp have,demonstrated
R3340 T4101 T4100 pobj contrast,in
R3341 T4102 T4101 prep to,contrast
R3342 T4103 T4106 det the,cells
R3343 T3962 T3964 det a,capacity
R3344 T4104 T4106 amod naive,cells
R3345 T4105 T4106 compound T,cells
R3346 T4106 T4102 pobj cells,to
R3347 T4107 T4109 punct (,2B
R3348 T4108 T4109 compound Figure,2B
R3349 T3963 T3964 amod limited,capacity
R3350 T4109 T4106 appos 2B,cells
R3351 T4110 T4106 punct ),cells
R3352 T4111 T4093 punct .,mediated
R3353 T3964 T3961 dobj capacity,have
R3354 T4112 T4114 mark Because,is
R3355 T4113 T4114 nsubj IL-4,is
R3356 T4114 T4134 advcl is,analyzed
R3357 T3965 T3966 aux to,express
R3358 T4115 T4118 det the,cytokine
R3359 T4116 T4118 amod key,cytokine
R3360 T4117 T4118 amod Th2,cytokine
R3361 T3966 T3964 acl express,capacity
R3362 T4118 T4114 attr cytokine,is
R3363 T3967 T3966 dobj FOXP3,express
R3364 T3968 T3970 punct (,1B
R3365 T4119 T4118 punct ",",cytokine
R3366 T3969 T3970 compound Figure,1B
R3367 T4120 T4121 det the,expression
R3368 T4121 T4134 nsubjpass expression,analyzed
R3369 T4122 T4121 prep of,expression
R3370 T4123 T4122 pobj IL-4,of
R3371 T4124 T4121 cc and,expression
R3372 T4125 T4121 conj FOXP3,expression
R3373 T3970 T3967 appos 1B,FOXP3
R3374 T4126 T4125 prep in,FOXP3
R3375 T4127 T4128 advmod freshly,isolated
R3376 T4128 T4129 amod isolated,CD4
R3377 T3971 T3970 punct ),1B
R3378 T4129 T4132 compound CD4,cells
R3379 T4130 T4132 nummod +,cells
R3380 T4131 T4132 compound T,cells
R3381 T3972 T3957 punct .,demonstrated
R3382 T4132 T4126 pobj cells,in
R3383 T4133 T4134 auxpass was,analyzed
R3384 T4134 T4134 ROOT analyzed,analyzed
R3385 T3973 T3974 det The,inability
R3386 T4135 T4134 agent by,analyzed
R3387 T4136 T4138 amod fluorescence,cell
R3388 T4137 T4138 amod activated,cell
R3389 T3974 T3983 nsubjpass inability,documented
R3390 T4138 T4135 pobj cell,by
R3391 T4139 T4138 acl sorting,cell
R3392 T4140 T4139 punct (,sorting
R3393 T3975 T3974 prep of,inability
R3394 T4141 T4139 appos FACS,sorting
R3395 T4142 T4134 punct ),analyzed
R3396 T4143 T4134 punct .,analyzed
R3397 T3976 T3977 amod Th2,cells
R3398 T4144 T4144 ROOT IL-4,IL-4
R3399 T4145 T4146 amod expressing,cells
R3400 T4146 T4147 nsubj cells,were
R3401 T3977 T3975 pobj cells,of
R3402 T4147 T4147 ROOT were,were
R3403 T4148 T4149 advmod most,abundant
R3404 T4149 T4147 acomp abundant,were
R3405 T4150 T4147 prep among,were
R3406 T3978 T3979 aux to,express
R3407 T4151 T4153 nummod CD45RO,CD25
R3408 T4152 T4153 nummod +,CD25
R3409 T3979 T3974 acl express,inability
R3410 T4153 T4150 pobj CD25,among
R3411 T4154 T4153 appos cells,CD25
R3412 T4155 T4153 punct ",",CD25
R3413 T4156 T4159 nsubj which,co-express
R3414 T3980 T3979 dobj FOXP3,express
R3415 T4157 T4159 aux did,co-express
R3416 T4158 T4159 neg not,co-express
R3417 T4159 T4153 relcl co-express,CD25
R3418 T4160 T4163 nmod FOXP3,3A
R3419 T4161 T4163 punct (,3A
R3420 T4162 T4163 compound Figure,3A
R3421 T3981 T3983 auxpass was,documented
R3422 T4163 T4159 oprd 3A,co-express
R3423 T4164 T4147 punct ",",were
R3424 T4165 T4147 dep left,were
R3425 T4166 T4165 dobj panel,left
R3426 T4167 T4147 punct ),were
R3427 T4168 T4147 punct .,were
R3428 T4169 T4178 prep In,expressed
R3429 T3982 T3983 advmod also,documented
R3430 T4170 T4169 pobj contrast,In
R3431 T4171 T4178 punct ",",expressed
R3432 T4172 T4174 compound CD45RO,CD25
R3433 T3983 T3983 ROOT documented,documented
R3434 T4173 T4174 compound +,CD25
R3435 T4174 T4178 nsubj CD25,expressed
R3436 T4175 T4176 amod +,cells
R3437 T3984 T3983 prep at,documented
R3438 T4176 T4178 nsubj cells,expressed
R3439 T4177 T4178 advmod abundantly,expressed
R3440 T4178 T4178 ROOT expressed,expressed
R3441 T3985 T3987 det the,level
R3442 T3986 T3987 amod single-cell,level
R3443 T3987 T3984 pobj level,at
R3444 T4179 T4178 dobj FOXP3,expressed
R3445 T3988 T3983 punct ",",documented
R3446 T4180 T4178 punct ",",expressed
R3447 T4181 T4182 mark while,lacking
R3448 T3989 T3983 advcl confirming,documented
R3449 T4182 T4178 advcl lacking,expressed
R3450 T4183 T4182 dobj IL-4,lacking
R3451 T3990 T3993 mark that,lack
R3452 T4184 T4186 punct (,3A
R3453 T4185 T4186 compound Figure,3A
R3454 T4186 T4183 parataxis 3A,IL-4
R3455 T4187 T4189 punct ",",panel
R3456 T4188 T4189 amod right,panel
R3457 T3991 T3992 amod Th2,cells
R3458 T3992 T3993 nsubj cells,lack
R3459 T3993 T3989 ccomp lack,confirming
R3460 T3994 T3995 nummod FOXP3,expression
R3461 T4189 T4186 appos panel,3A
R3462 T4190 T4186 punct ),3A
R3463 T4286 T4287 compound cell,isolation
R3464 T4191 T4178 punct .,expressed
R3465 T4192 T4193 mark As,shown
R3466 T4193 T4205 advcl shown,was
R3467 T4194 T4193 prep in,shown
R3468 T4195 T4196 compound Figure,3B
R3469 T4196 T4194 pobj 3B,in
R3470 T4287 T4288 compound isolation,technology
R3471 T4288 T4283 dobj technology,using
R3472 T4197 T4205 punct ",",was
R3473 T4198 T4199 det the,frequency
R3474 T4289 T4278 conj contained,enriched
R3475 T4199 T4205 nsubj frequency,was
R3476 T4200 T4199 prep of,frequency
R3477 T4201 T4204 det the,cells
R3478 T4290 T4292 det some,cells
R3479 T4202 T4204 compound IL-4,cells
R3480 T4203 T4204 compound +,cells
R3481 T4204 T4200 pobj cells,of
R3482 T4291 T4292 amod FOXP3-expressing,cells
R3483 T4205 T4205 ROOT was,was
R3484 T4206 T4207 advmod always,below
R3485 T4292 T4289 dobj cells,contained
R3486 T4207 T4205 prep below,was
R3487 T4208 T4209 nummod 1,%
R3488 T4209 T4207 pobj %,below
R3489 T4293 T4289 punct ",",contained
R3490 T4210 T4209 prep in,%
R3491 T4211 T4214 det the,cells
R3492 T4294 T4289 cc but,contained
R3493 T4212 T4214 nummod FOXP3,cells
R3494 T4213 T4214 compound +,cells
R3495 T4214 T4210 pobj cells,in
R3496 T4215 T4209 amod close,%
R3497 T4216 T4215 prep to,close
R3498 T4295 T4301 advmod importantly,overlap
R3499 T4217 T4218 det the,background
R3500 T4218 T4216 pobj background,to
R3501 T4296 T4301 punct ",",overlap
R3502 T4219 T4205 punct .,was
R3503 T4220 T4223 det The,cells
R3504 T4221 T4223 compound IL-4,cells
R3505 T4222 T4223 compound +,cells
R3506 T4297 T4298 det the,expression
R3507 T4223 T4225 nsubjpass cells,confined
R3508 T4224 T4225 auxpass were,confined
R3509 T4225 T4225 ROOT confined,confined
R3510 T4298 T4301 nsubj expression,overlap
R3511 T4226 T4225 prep to,confined
R3512 T4227 T4228 det the,FOXP3
R3513 T4228 T4226 pobj FOXP3,to
R3514 T4299 T4301 aux did,overlap
R3515 T4229 T4228 appos cells,FOXP3
R3516 T4230 T4225 punct ",",confined
R3517 T4231 T4232 mark as,shown
R3518 T4300 T4301 neg not,overlap
R3519 T4232 T4225 advcl shown,confined
R3520 T4233 T4232 prep for,shown
R3521 T4234 T4237 det the,CD25
R3522 T4235 T4237 compound CD45RO,CD25
R3523 T4236 T4237 compound +,CD25
R3524 T4237 T4233 pobj CD25,for
R3525 T4301 T4278 advcl overlap,enriched
R3526 T4238 T4232 punct ",",shown
R3527 T4239 T4242 compound CD45RO,+
R3528 T4240 T4242 compound +,+
R3529 T4241 T4242 compound CD25,+
R3530 T4302 T4278 punct .,enriched
R3531 T4242 T4242 ROOT +,+
R3532 T4243 T4242 punct ",",+
R3533 T4244 T4242 cc and,+
R3534 T4303 T4308 advcl Taken,indicate
R3535 T4245 T4247 compound CD45RO,CD25
R3536 T4246 T4247 compound +,CD25
R3537 T4247 T4242 conj CD25,+
R3538 T4304 T4303 advmod together,Taken
R3539 T4248 T4250 advmod +,cells
R3540 T4249 T4250 amod high,cells
R3541 T4305 T4308 punct ",",indicate
R3542 T4250 T4242 appos cells,+
R3543 T4251 T4253 punct (,3B
R3544 T4252 T4253 compound Figure,3B
R3545 T4253 T4250 appos 3B,cells
R3546 T4306 T4307 det these,data
R3547 T4254 T4250 punct ),cells
R3548 T4255 T4225 punct .,confined
R3549 T4256 T4270 prep In,expressed
R3550 T4307 T4308 nsubj data,indicate
R3551 T4257 T4256 pobj addition,In
R3552 T4258 T4270 punct ",",expressed
R3553 T4308 T4308 ROOT indicate,indicate
R3554 T4259 T4262 preconj neither,clone
R3555 T4260 T4262 det the,clone
R3556 T4261 T4262 amod Th2,clone
R3557 T4309 T4313 mark that,expressed
R3558 T4262 T4270 nsubj clone,expressed
R3559 T4263 T4262 punct (,clone
R3560 T4264 T4262 appos BR8,clone
R3561 T4310 T4313 nsubjpass FOXP3,expressed
R3562 T4265 T4262 punct ),clone
R3563 T4266 T4262 cc nor,clone
R3564 T4311 T4313 auxpass was,expressed
R3565 T4267 T4268 amod CRTH2,cells
R3566 T4268 T4262 conj cells,clone
R3567 T4269 T4270 advmod significantly,expressed
R3568 T4312 T4313 neg not,expressed
R3569 T4270 T4270 ROOT expressed,expressed
R3570 T4271 T4270 dobj FOXP3,expressed
R3571 T4272 T4274 punct (,3C
R3572 T4273 T4274 compound Figure,3C
R3573 T4313 T4308 ccomp expressed,indicate
R3574 T4274 T4271 appos 3C,FOXP3
R3575 T4314 T4313 agent by,expressed
R3576 T4275 T4274 punct ),3C
R3577 T4276 T4270 punct .,expressed
R3578 T4315 T4316 amod Th2,cells
R3579 T4277 T4278 nsubj Cells,enriched
R3580 T4278 T4278 ROOT enriched,enriched
R3581 T4316 T4314 pobj cells,by
R3582 T4279 T4278 prep for,enriched
R3583 T4280 T4282 poss their,secretion
R3584 T4281 T4282 compound IL-4,secretion
R3585 T4317 T4313 cc and,expressed
R3586 T4282 T4279 pobj secretion,for
R3587 T4283 T4278 advcl using,enriched
R3588 T4318 T4313 conj was,expressed
R3589 T4284 T4288 det the,technology
R3590 T4285 T4287 amod magnetic,isolation
R3591 T4319 T4318 neg not,was
R3592 T4320 T4318 acomp inducible,was
R3593 T4321 T4320 prep in,inducible
R3594 T4322 T4323 det those,cells
R3595 T4323 T4321 pobj cells,in
R3596 T4324 T4308 punct .,indicate
R17704 T23591 T23595 npadvmod Th2,Induce
R17705 T23592 T23595 nsubj Cells,Induce
R17706 T23593 T23595 aux Can,Induce
R17707 T23594 T23595 neg not,Induce
R17708 T23595 T23595 ROOT Induce,Induce
R17709 T23596 T23597 compound FOXP3,Expression
R17710 T23597 T23595 dobj Expression,Induce
R17711 T23598 T23597 punct (,Expression
R17712 T23599 T23597 appos A,Expression
R17713 T23600 T23599 punct ),A
R17714 T23601 T23602 compound Human,T
R17715 T23602 T23603 compound T,cells
R17716 T23603 T23605 nsubjpass cells,activated
R17717 T23604 T23605 auxpass were,activated
R17718 T23605 T23595 ccomp activated,Induce
R17719 T23606 T23605 prep with,activated
R17720 T23607 T23609 nmod plate-bound,/
R17721 T23608 T23609 amod anti-CD3,/
R17722 T23609 T23606 pobj /,with
R17723 T23610 T23609 nummod CD28,/
R17724 T23611 T23606 conj with,with
R17725 T23612 T23611 cc or,with
R17726 T23613 T23611 conj without,with
R17727 T23614 T23613 pobj TGF-β,without
R17728 T23615 T23616 mark as,indicated
R17729 T23616 T23605 advcl indicated,activated
R17730 T23617 T23616 prep on,indicated
R17731 T23618 T23619 det the,x-axis
R17732 T23619 T23617 pobj x-axis,on
R17733 T23620 T23619 prep of,x-axis
R17734 T23621 T23622 punct (,B
R17735 T23622 T23620 pobj B,of
R17736 T23623 T23622 punct ),B
R17737 T23624 T23595 punct .,Induce
R17738 T23625 T23627 nsubjpass Cells,harvested
R17739 T23626 T23627 auxpass were,harvested
R17740 T23627 T23627 ROOT harvested,harvested
R17741 T23628 T23627 prep after,harvested
R17742 T23629 T23630 nummod 5,days
R17743 T23630 T23628 pobj days,after
R17744 T23631 T23630 cc and,days
R17745 T23632 T23633 nummod FOXP3,mRNA
R17746 T23633 T23630 conj mRNA,days
R17747 T23634 T23635 auxpass was,quantified
R17748 T23635 T23627 conj quantified,harvested
R17749 T23636 T23635 agent by,quantified
R17750 T23637 T23638 amod real-time,PCR
R17751 T23638 T23636 pobj PCR,by
R17752 T23639 T23627 punct .,harvested
R17753 T23640 T23641 nsubj Bars,show
R17754 T23641 T23641 ROOT show,show
R17755 T23642 T23645 det the,SD
R17756 T23643 T23645 amod mean,SD
R17757 T23644 T23645 compound ±,SD
R17758 T23645 T23641 dobj SD,show
R17759 T23646 T23645 prep of,SD
R17760 T23647 T23649 nummod 4,experiments
R17761 T23648 T23649 amod independent,experiments
R17762 T23649 T23646 pobj experiments,of
R17763 T23650 T23641 punct .,show
R17764 T23651 T23652 punct (,B
R17765 T23652 T23652 ROOT B,B
R17766 T23653 T23652 punct ),B
R17767 T23654 T23665 prep In,activated
R17768 T23655 T23654 pobj vitro,In
R17769 T23656 T23657 amod differentiated,Th1
R17770 T23657 T23663 nmod Th1,cells
R17771 T23658 T23659 punct ",",Th2
R17772 T23659 T23657 conj Th2,Th1
R17773 T23660 T23659 punct ",",Th2
R17774 T23661 T23659 cc or,Th2
R17775 T23662 T23659 conj iTreg,Th2
R17776 T23663 T23665 nsubjpass cells,activated
R17777 T23664 T23665 auxpass were,activated
R17778 T23665 T23665 ROOT activated,activated
R17779 T23666 T23665 prep with,activated
R17780 T23667 T23669 amod anti-CD3,CD28
R17781 T23668 T23669 compound /,CD28
R17782 T23669 T23666 pobj CD28,with
R17783 T23670 T23669 punct ",",CD28
R17784 T23671 T23669 conj TGF-β,CD28
R17785 T23672 T23671 punct ",",TGF-β
R17786 T23673 T23671 cc or,TGF-β
R17787 T23674 T23671 conj anti-IL-4,TGF-β
R17788 T23675 T23676 mark as,indicated
R17789 T23676 T23665 advcl indicated,activated
R17790 T23677 T23665 punct .,activated
R17791 T23678 T23679 det The,phenotype
R17792 T23679 T23684 nsubjpass phenotype,confirmed
R17793 T23680 T23679 prep of,phenotype
R17794 T23681 T23682 det these,cells
R17795 T23682 T23680 pobj cells,of
R17796 T23683 T23684 auxpass was,confirmed
R17797 T23684 T23684 ROOT confirmed,confirmed
R17798 T23685 T23684 agent by,confirmed
R17799 T23686 T23685 pobj FACS,by
R17800 T23687 T23686 cc and,FACS
R17801 T23688 T23689 compound proliferation,analysis
R17802 T23689 T23686 conj analysis,FACS
R17803 T23690 T23691 punct (,Figure
R17804 T23691 T23689 appos Figure,analysis
R17805 T23692 T23691 nummod S1,Figure
R17806 T23693 T23691 punct ),Figure
R17807 T23694 T23684 punct .,confirmed
R17808 T23695 T23696 nsubj Bars,show
R17809 T23696 T23696 ROOT show,show
R17810 T23697 T23700 det the,SD
R17811 T23698 T23700 amod mean,SD
R17812 T23699 T23700 compound ±,SD
R17813 T23700 T23696 dobj SD,show
R17814 T23701 T23700 prep of,SD
R17815 T23702 T23704 nummod four,experiments
R17816 T23703 T23704 amod independent,experiments
R17817 T23704 T23701 pobj experiments,of
R17818 T23705 T23696 punct .,show
R17929 T23907 T23908 nummod Th2,Cells
R17930 T23908 T23908 ROOT Cells,Cells
R17931 T23909 T23912 nmod Do,FOXP3
R17932 T23910 T23912 neg Not,FOXP3
R17933 T23911 T23912 compound Express,FOXP3
R17934 T23912 T23908 appos FOXP3,Cells
R17935 T23913 T23914 punct (,A
R17936 T23914 T23912 appos A,FOXP3
R17937 T23915 T23912 punct ),FOXP3
R17938 T23916 T23917 compound Intracellular,FACS
R17939 T23917 T23918 compound FACS,analysis
R17940 T23918 T23935 nsubj analysis,see
R17941 T23919 T23918 prep of,analysis
R17942 T23920 T23921 nummod FOXP3,expression
R17943 T23921 T23919 pobj expression,of
R17944 T23922 T23921 prep in,expression
R17945 T23923 T23922 pobj Th1,in
R17946 T23924 T23923 punct ",",Th1
R17947 T23925 T23923 conj Th2,Th1
R17948 T23926 T23925 punct ",",Th2
R17949 T23927 T23925 cc or,Th2
R17950 T23928 T23929 amod iTreg-differentiated,cells
R17951 T23929 T23925 conj cells,Th2
R17952 T23930 T23929 punct (,cells
R17953 T23931 T23932 nummod two,rounds
R17954 T23932 T23929 conj rounds,cells
R17955 T23933 T23932 punct ",",rounds
R17956 T23934 T23935 nsubj phenotype,see
R17957 T23935 T23935 ROOT see,see
R17958 T23936 T23935 dobj Figure,see
R17959 T23937 T23936 nummod S1,Figure
R17960 T23938 T23936 punct ),Figure
R17961 T23939 T23935 punct ",",see
R17962 T23940 T23935 dep rested,see
R17963 T23941 T23940 cc or,rested
R17964 T23942 T23940 conj activated,rested
R17965 T23943 T23942 punct ",",activated
R17966 T23944 T23942 prep with,activated
R17967 T23945 T23944 cc or,with
R17968 T23946 T23944 conj without,with
R17969 T23947 T23946 pobj TGF-β,without
R17970 T23948 T23935 punct .,see
R17971 T23949 T23950 nummod FOXP3,expression
R17972 T23950 T23952 nsubjpass expression,measured
R17973 T23951 T23952 auxpass was,measured
R17974 T23952 T23952 ROOT measured,measured
R17975 T23953 T23952 prep after,measured
R17976 T23954 T23955 nummod 5,d
R17977 T23955 T23953 pobj d,after
R17978 T23956 T23955 prep in,d
R17979 T23957 T23956 pobj culture,in
R17980 T23958 T23952 punct .,measured
R17981 T23959 T23961 det The,blots
R17982 T23960 T23961 amod dot,blots
R17983 T23961 T23962 nsubj blots,are
R17984 T23962 T23962 ROOT are,are
R17985 T23963 T23962 attr representative,are
R17986 T23964 T23963 prep of,representative
R17987 T23965 T23967 nummod three,experiments
R17988 T23966 T23967 amod independent,experiments
R17989 T23967 T23964 pobj experiments,of
R17990 T23968 T23962 punct .,are
R17991 T23969 T23970 punct (,B
R17992 T23970 T23972 nsubj B,Shows
R17993 T23971 T23970 punct ),B
R17994 T23972 T23972 ROOT Shows,Shows
R17995 T23973 T23976 det the,setup
R17996 T23974 T23976 amod same,setup
R17997 T23975 T23976 amod experimental,setup
R17998 T23976 T23972 dobj setup,Shows
R17999 T23977 T23972 punct ",",Shows
R18000 T23978 T23972 cc but,Shows
R18001 T23979 T23980 advmod naturally,occurring
R18002 T23980 T23972 conj occurring,Shows
R18003 T23981 T23982 amod Th2,cells
R18004 T23982 T23984 nsubjpass cells,analyzed
R18005 T23983 T23984 auxpass were,analyzed
R18006 T23984 T23980 advcl analyzed,occurring
R18007 T23985 T23972 punct .,Shows
R18008 T23986 T23987 nsubj Data,are
R18009 T23987 T23987 ROOT are,are
R18010 T23988 T23987 attr representative,are
R18011 T23989 T23988 prep of,representative
R18012 T23990 T23992 nummod three,experiments
R18013 T23991 T23992 amod independent,experiments
R18014 T23992 T23989 pobj experiments,of
R18015 T23993 T23987 punct .,are
R18208 T24303 T24303 ROOT Th2,Th2
R18209 T24304 T24303 punct -,Th2
R18210 T24305 T24303 cc or,Th2
R18211 T24306 T24315 nmod IL-4,analysis
R18212 T24307 T24308 compound Producing,Cells
R18213 T24308 T24310 compound Cells,FOXP3
R18214 T24309 T24310 compound Lack,FOXP3
R18215 T24310 T24306 appos FOXP3,IL-4
R18216 T24311 T24312 punct (,A
R18217 T24312 T24310 appos A,FOXP3
R18218 T24313 T24310 punct ),FOXP3
R18219 T24314 T24315 compound FACS,analysis
R18220 T24315 T24303 conj analysis,Th2
R18221 T24316 T24315 prep of,analysis
R18222 T24317 T24318 amod intracellular,FOXP3
R18223 T24318 T24316 pobj FOXP3,of
R18224 T24319 T24318 cc and,FOXP3
R18225 T24320 T24321 compound IL-4,expression
R18226 T24321 T24315 conj expression,analysis
R18227 T24322 T24303 prep following,Th2
R18228 T24323 T24324 compound PMA/Ionomycin,stimulation
R18229 T24324 T24322 pobj stimulation,following
R18230 T24325 T24322 punct .,following
R18231 T24326 T24329 nummod CD4,cells
R18232 T24327 T24329 nummod +,cells
R18233 T24328 T24329 compound T,cells
R18234 T24329 T24331 nsubjpass cells,gated
R18235 T24330 T24331 auxpass were,gated
R18236 T24331 T24331 ROOT gated,gated
R18237 T24332 T24331 prep on,gated
R18238 T24333 T24334 det the,basis
R18239 T24334 T24332 pobj basis,on
R18240 T24335 T24334 prep of,basis
R18241 T24336 T24335 pobj CD45RO,of
R18242 T24337 T24336 cc and,CD45RO
R18243 T24338 T24340 nummod CD25,expression
R18244 T24339 T24340 compound surface,expression
R18245 T24340 T24336 conj expression,CD45RO
R18246 T24341 T24340 punct (,expression
R18247 T24342 T24343 amod upper,panel
R18248 T24343 T24340 appos panel,expression
R18249 T24344 T24340 punct ),expression
R18250 T24345 T24331 punct ",",gated
R18251 T24346 T24331 cc and,gated
R18252 T24347 T24348 amod gated,cells
R18253 T24348 T24350 nsubjpass cells,shown
R18254 T24349 T24350 auxpass are,shown
R18255 T24350 T24331 conj shown,gated
R18256 T24351 T24350 prep below,shown
R18257 T24352 T24350 prep for,shown
R18258 T24353 T24357 det the,−
R18259 T24354 T24357 compound CD45RO,−
R18260 T24355 T24357 compound +,−
R18261 T24356 T24357 compound CD25,−
R18262 T24357 T24352 pobj −,for
R18263 T24358 T24359 punct (,A
R18264 T24359 T24357 appos A,−
R18265 T24360 T24361 punct ",",left
R18266 T24361 T24350 advcl left,shown
R18267 T24362 T24361 dobj panel,left
R18268 T24363 T24350 punct ),shown
R18269 T24364 T24381 punct ",",subsets
R18270 T24365 T24369 det the,+
R18271 T24366 T24369 compound CD45RO,+
R18272 T24367 T24369 compound +,+
R18273 T24368 T24369 compound CD25,+
R18274 T24369 T24381 nmod +,subsets
R18275 T24370 T24372 punct (,panel
R18276 T24371 T24372 amod right,panel
R18277 T24372 T24369 appos panel,+
R18278 T24373 T24372 punct ),panel
R18279 T24374 T24369 punct ",",+
R18280 T24375 T24369 cc and,+
R18281 T24376 T24379 det the,CD25
R18282 T24377 T24379 compound CD45RO,CD25
R18283 T24378 T24379 compound −,CD25
R18284 T24379 T24369 conj CD25,+
R18285 T24380 T24381 compound −,subsets
R18286 T24381 T24331 conj subsets,gated
R18287 T24382 T24381 punct (,subsets
R18288 T24383 T24384 amod central,panel
R18289 T24384 T24381 appos panel,subsets
R18290 T24385 T24381 punct ),subsets
R18291 T24386 T24381 punct .,subsets
R18292 T24387 T24389 det A,analysis
R18293 T24388 T24389 amod statistical,analysis
R18294 T24389 T24401 nsubjpass analysis,shown
R18295 T24390 T24389 prep of,analysis
R18296 T24391 T24393 nummod eight,donors
R18297 T24392 T24393 amod independent,donors
R18298 T24393 T24390 pobj donors,of
R18299 T24394 T24389 prep after,analysis
R18300 T24395 T24394 pobj subtraction,after
R18301 T24396 T24395 prep of,subtraction
R18302 T24397 T24399 det the,control
R18303 T24398 T24399 compound isotype,control
R18304 T24399 T24396 pobj control,of
R18305 T24400 T24401 auxpass are,shown
R18306 T24401 T24401 ROOT shown,shown
R18307 T24402 T24401 prep in,shown
R18308 T24403 T24404 punct (,B
R18309 T24404 T24402 pobj B,in
R18310 T24405 T24404 punct ),B
R18311 T24406 T24401 punct .,shown
R18312 T24407 T24410 det The,line
R18313 T24408 T24410 amod dotted,line
R18314 T24409 T24410 amod gray,line
R18315 T24410 T24411 nsubj line,indicates
R18316 T24411 T24411 ROOT indicates,indicates
R18317 T24412 T24415 det the,level
R18318 T24413 T24415 compound IC,level
R18319 T24414 T24415 compound background,level
R18320 T24415 T24411 dobj level,indicates
R18321 T24416 T24411 punct .,indicates
R18322 T24417 T24419 det The,bars
R18323 T24418 T24419 compound error,bars
R18324 T24419 T24420 nsubj bars,show
R18325 T24420 T24420 ROOT show,show
R18326 T24421 T24422 det the,error
R18327 T24422 T24420 dobj error,show
R18328 T24423 T24422 prep of,error
R18329 T24424 T24425 det the,mean
R18330 T24425 T24423 pobj mean,of
R18331 T24426 T24420 punct .,show
R18332 T24427 T24428 punct (,C
R18333 T24428 T24428 ROOT C,C
R18334 T24429 T24428 punct ),C
R18335 T24430 T24455 advmod Similarly,stained
R18336 T24431 T24455 punct ",",stained
R18337 T24432 T24434 det a,clone
R18338 T24433 T24434 amod Th2,clone
R18339 T24434 T24455 nsubjpass clone,stained
R18340 T24435 T24434 punct (,clone
R18341 T24436 T24434 appos BR8,clone
R18342 T24437 T24434 punct ),clone
R18343 T24438 T24434 punct ",",clone
R18344 T24439 T24442 compound CRTH2,cells
R18345 T24440 T24442 compound +,cells
R18346 T24441 T24442 compound Th2,cells
R18347 T24442 T24434 conj cells,clone
R18348 T24443 T24442 punct ",",cells
R18349 T24444 T24445 amod IL-4-secreting,cells
R18350 T24445 T24442 conj cells,cells
R18351 T24446 T24445 punct ",",cells
R18352 T24447 T24445 cc and,cells
R18353 T24448 T24450 compound memory,cells
R18354 T24449 T24450 compound T,cells
R18355 T24450 T24445 conj cells,cells
R18356 T24451 T24450 punct (,cells
R18357 T24452 T24450 appos CD45RO,cells
R18358 T24453 T24450 punct ),cells
R18359 T24454 T24455 auxpass were,stained
R18360 T24455 T24455 ROOT stained,stained
R18361 T24456 T24455 prep for,stained
R18362 T24457 T24456 pobj FOXP3,for
R18363 T24458 T24457 cc and,FOXP3
R18364 T24459 T24457 conj IL-4,FOXP3
R18365 T24460 T24455 punct .,stained
R18366 T24461 T24462 nsubj Data,are
R18367 T24462 T24462 ROOT are,are
R18368 T24463 T24462 attr representative,are
R18369 T24464 T24463 prep of,representative
R18370 T24465 T24467 nummod three,experiments
R18371 T24466 T24467 amod independent,experiments
R18372 T24467 T24464 pobj experiments,of
R18373 T24468 T24462 punct .,are

UBERON-AE

Id Subject Object Predicate Lexical cue
T24097 4700-4707 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central

GO-BP

Id Subject Object Predicate Lexical cue
T2890 147-167 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T2891 498-504 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T2892 753-756 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T2893 1756-1765 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2894 2593-2607 http://purl.obolibrary.org/obo/GO_0072602 denotes IL-4 secretion
T2895 3582-3596 http://purl.obolibrary.org/obo/GO_0072602 denotes IL-4 secretion
T2896 2598-2607 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T2897 3587-3596 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T2898 2941-2955 http://purl.obolibrary.org/obo/GO_0001775 denotes activated cell
T23814 3961-3981 http://purl.obolibrary.org/obo/GO_0030154 denotes differentiated cells
T24132 5003-5009 http://purl.obolibrary.org/obo/GO_0007613 denotes memory

GO-MF

Id Subject Object Predicate Lexical cue
T4454 1857-1865 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T23717 1504-1508 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T24496 4348-4352 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T24497 4425-4429 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T24498 4977-4981 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T24499 5054-5058 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4442 1704-1708 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4443 1831-1835 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4444 1852-1856 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4445 2593-2597 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4446 2615-2619 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4447 2816-2820 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4448 2864-2868 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4449 2972-2976 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4450 3169-3173 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4451 3244-3248 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4452 3325-3329 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4453 3582-3586 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4

GO-CC

Id Subject Object Predicate Lexical cue
T4459 507-512 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4460 539-544 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4461 795-800 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4462 850-855 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4463 957-962 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4464 1107-1112 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T4465 1924-1929 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4466 1983-1988 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4467 2064-2069 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4468 2153-2158 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4469 2205-2210 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4470 2296-2301 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4471 2496-2501 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4472 2527-2532 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4473 2550-2555 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4474 2559-2564 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4475 2756-2761 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4476 2789-2794 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4477 2906-2911 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4478 2988-2993 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4479 3032-3037 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4480 3121-3126 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4481 3250-3255 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4482 3290-3295 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4483 3331-3336 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4484 3365-3370 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4485 3438-3443 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4486 3508-3513 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4487 3674-3679 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4488 3802-3807 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4489 3839-3844 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4490 753-756 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T4491 1857-1865 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T4492 1857-1865 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T23718 1156-1161 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23719 1448-1453 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23720 1546-1551 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24001 3891-3904 http://purl.obolibrary.org/obo/GO_0005622 denotes Intracellular
T24002 3976-3981 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24003 4251-4256 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24500 4401-4414 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T24501 4485-4490 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24502 4578-4583 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24503 4970-4975 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24504 4992-4997 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24505 5012-5017 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4455 104-109 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4456 208-213 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4457 433-438 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4458 466-471 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T2865 0-33 Sentence denotes FOXP3 Induction in T Cell Subsets
T2866 34-168 Sentence denotes It is assumed that FOXP3 expression can be induced in nonregulatory T cells, which is an important step in iTreg cell differentiation.
T2867 169-254 Sentence denotes However, it is not known if all CD4+ T cells have the same capacity to express FOXP3.
T2868 255-634 Sentence denotes To investigate whether FOXP3 can be expressed by any T cell subset or if expression is restricted to a distinct lineage, FOXP3 mRNA expression was analyzed in freshly isolated T cells such as CD25-depleted CD4+ cells, CD45RA+ naive or CD45RO+ memory T cells (Figure 1A), as well as T cells driven in vitro toward Th1, Th2, or iTreg phenotypes (Figure 1B; phenotype on Figure S1).
T2869 635-790 Sentence denotes The CD4+CD25–, CD45RA+, CD45RO+, and CD4+CD45RO+CD25– were able to significantly induce FOXP3 mRNA up to 30-fold upon TCR activation and addition of TGF-β.
T2870 791-832 Sentence denotes Th1 cells showed only a 10-fold increase.
T2871 833-927 Sentence denotes In contrast, Th2 cells stimulated under the same conditions did not increase FOXP3 expression.
T2872 928-1092 Sentence denotes The in vitro generated iTreg cells were unable to further up-regulate FOXP3, which was already at high levels under the resting conditions (Figure 1B, right panel).
T2873 1103-1799 Sentence denotes Th2 Cells Cannot Induce FOXP3 Expression (A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B). Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR. Bars show the mean ± SD of 4 independent experiments. (B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated. The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1). Bars show the mean ± SD of four independent experiments. Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction.
T2874 1800-1949 Sentence denotes However, the neutralization of IL-4 with a blocking IL-4 antibody did not rescue FOXP3 expression in the differentiated Th2 cells (unpublished data).
T2875 1950-2042 Sentence denotes These data demonstrated that Th2 cells have a limited capacity to express FOXP3 (Figure 1B).
T2876 2043-2193 Sentence denotes The inability of Th2 cells to express FOXP3 was also documented at the single-cell level, confirming that Th2 cells lack FOXP3 expression (Figure 2A).
T2877 2194-2249 Sentence denotes Only iTreg cells expressed FOXP3 in resting conditions.
T2878 2250-2353 Sentence denotes Interestingly, we observed that resting iTreg cells express FOXP3 but show low CD25 surface expression.
T2879 2354-2502 Sentence denotes Repeated exposure to TGF-β did not further increase the FOXP3 expression in the iTreg lineage but transiently induced FOXP3 expression in Th1 cells.
T2880 2503-2696 Sentence denotes Naturally occurring Th2 cells such as CRTH2+ T cells, T cells isolated according to their IL-4 secretion, or an IL-4–producing T cell clone (BR8) were also lacking FOXP3 expression (Figure 2B).
T2881 2697-2807 Sentence denotes Furthermore TGF-β–mediated FOXP3 induction failed in these cells in contrast to the naive T cells (Figure 2B).
T2882 2808-2971 Sentence denotes Because IL-4 is the key Th2 cytokine, the expression of IL-4 and FOXP3 in freshly isolated CD4+ T cells was analyzed by fluorescence activated cell sorting (FACS).
T2883 2972-3094 Sentence denotes IL-4–expressing cells were most abundant among CD45RO+CD25– cells, which did not co-express FOXP3 (Figure 3A, left panel).
T2884 3095-3199 Sentence denotes In contrast, CD45RO+CD25+ cells abundantly expressed FOXP3, while lacking IL-4 (Figure 3A, right panel).
T2885 3200-3320 Sentence denotes As shown in Figure 3B, the frequency of the IL-4+ cells was always below 1% in the FOXP3+ cells close to the background.
T2886 3321-3456 Sentence denotes The IL-4+ cells were confined to the FOXP3– cells, as shown for the CD45RO+CD25–, CD45RO+CD25+, and CD45RO+CD25+high cells (Figure 3B).
T2887 3457-3556 Sentence denotes In addition, neither the Th2 clone (BR8) nor CRTH2 cells significantly expressed FOXP3 (Figure 3C).
T2888 3557-3729 Sentence denotes Cells enriched for their IL-4 secretion using the magnetic cell isolation technology contained some FOXP3-expressing cells, but importantly, the expression did not overlap.
T2889 3730-3845 Sentence denotes Taken together, these data indicate that FOXP3 was not expressed by Th2 cells and was not inducible in those cells.
T23457 1103-1143 Sentence denotes Th2 Cells Cannot Induce FOXP3 Expression
T23458 1144-1264 Sentence denotes (A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B).
T23459 1265-1346 Sentence denotes Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR.
T23460 1347-1400 Sentence denotes Bars show the mean ± SD of 4 independent experiments.
T23461 1401-1522 Sentence denotes (B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated.
T23462 1523-1613 Sentence denotes The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1).
T23463 1614-1670 Sentence denotes Bars show the mean ± SD of four independent experiments.
T23808 3856-3886 Sentence denotes Th2 Cells Do Not Express FOXP3
T23809 3887-4064 Sentence denotes (A) Intracellular FACS analysis of FOXP3 expression in Th1, Th2, or iTreg-differentiated cells (two rounds, phenotype see Figure S1), rested or activated, with or without TGF-β.
T23810 4065-4116 Sentence denotes FOXP3 expression was measured after 5 d in culture.
T23811 4117-4183 Sentence denotes The dot blots are representative of three independent experiments.
T23812 4184-4271 Sentence denotes (B) Shows the same experimental setup, but naturally occurring Th2 cells were analyzed.
T23813 4272-4329 Sentence denotes Data are representative of three independent experiments.
T24125 4340-4379 Sentence denotes Th2- or IL-4–Producing Cells Lack FOXP3
T24126 4380-4477 Sentence denotes (A) FACS analysis of intracellular FOXP3 and IL-4 expression following PMA/Ionomycin stimulation.
T24127 4478-4715 Sentence denotes CD4+ T cells were gated on the basis of CD45RO and CD25 surface expression (upper panel), and gated cells are shown below for the CD45RO+CD25− (A, left panel), the CD45RO+CD25+ (right panel), and the CD45RO−CD25− subsets (central panel).
T24128 4716-4825 Sentence denotes A statistical analysis of eight independent donors after subtraction of the isotype control are shown in (B).
T24129 4826-4881 Sentence denotes The dotted gray line indicates the IC background level.
T24130 4882-5059 Sentence denotes The error bars show the error of the mean. (C) Similarly, a Th2 clone (BR8), CRTH2+ Th2 cells, IL-4-secreting cells, and memory T cells (CD45RO) were stained for FOXP3 and IL-4.
T24131 5060-5117 Sentence denotes Data are representative of three independent experiments.
T43 0-33 Sentence denotes FOXP3 Induction in T Cell Subsets
T44 34-168 Sentence denotes It is assumed that FOXP3 expression can be induced in nonregulatory T cells, which is an important step in iTreg cell differentiation.
T45 169-254 Sentence denotes However, it is not known if all CD4+ T cells have the same capacity to express FOXP3.
T46 255-634 Sentence denotes To investigate whether FOXP3 can be expressed by any T cell subset or if expression is restricted to a distinct lineage, FOXP3 mRNA expression was analyzed in freshly isolated T cells such as CD25-depleted CD4+ cells, CD45RA+ naive or CD45RO+ memory T cells (Figure 1A), as well as T cells driven in vitro toward Th1, Th2, or iTreg phenotypes (Figure 1B; phenotype on Figure S1).
T47 635-790 Sentence denotes The CD4+CD25–, CD45RA+, CD45RO+, and CD4+CD45RO+CD25– were able to significantly induce FOXP3 mRNA up to 30-fold upon TCR activation and addition of TGF-β.
T48 791-832 Sentence denotes Th1 cells showed only a 10-fold increase.
T49 833-927 Sentence denotes In contrast, Th2 cells stimulated under the same conditions did not increase FOXP3 expression.
T50 928-1092 Sentence denotes The in vitro generated iTreg cells were unable to further up-regulate FOXP3, which was already at high levels under the resting conditions (Figure 1B, right panel).
T51 1093-1143 Sentence denotes Figure 1 Th2 Cells Cannot Induce FOXP3 Expression
T52 1144-1264 Sentence denotes (A) Human T cells were activated with plate-bound anti-CD3/CD28 with or without TGF-β as indicated on the x-axis of (B).
T53 1265-1346 Sentence denotes Cells were harvested after 5 days and FOXP3 mRNA was quantified by real-time PCR.
T54 1347-1400 Sentence denotes Bars show the mean ± SD of 4 independent experiments.
T55 1401-1522 Sentence denotes (B) In vitro differentiated Th1, Th2, or iTreg cells were activated with anti-CD3/CD28, TGF-β, or anti-IL-4 as indicated.
T56 1523-1613 Sentence denotes The phenotype of these cells was confirmed by FACS and proliferation analysis (Figure S1).
T57 1614-1670 Sentence denotes Bars show the mean ± SD of four independent experiments.
T58 1673-1799 Sentence denotes Th2 cells are known to produce IL-4 upon activation, which may interact with TGF-β signaling and thus prevent FOXP3 induction.
T59 1800-1949 Sentence denotes However, the neutralization of IL-4 with a blocking IL-4 antibody did not rescue FOXP3 expression in the differentiated Th2 cells (unpublished data).
T60 1950-2042 Sentence denotes These data demonstrated that Th2 cells have a limited capacity to express FOXP3 (Figure 1B).
T61 2043-2193 Sentence denotes The inability of Th2 cells to express FOXP3 was also documented at the single-cell level, confirming that Th2 cells lack FOXP3 expression (Figure 2A).
T62 2194-2249 Sentence denotes Only iTreg cells expressed FOXP3 in resting conditions.
T63 2250-2353 Sentence denotes Interestingly, we observed that resting iTreg cells express FOXP3 but show low CD25 surface expression.
T64 2354-2502 Sentence denotes Repeated exposure to TGF-β did not further increase the FOXP3 expression in the iTreg lineage but transiently induced FOXP3 expression in Th1 cells.
T65 2503-2696 Sentence denotes Naturally occurring Th2 cells such as CRTH2+ T cells, T cells isolated according to their IL-4 secretion, or an IL-4–producing T cell clone (BR8) were also lacking FOXP3 expression (Figure 2B).
T66 2697-2807 Sentence denotes Furthermore TGF-β–mediated FOXP3 induction failed in these cells in contrast to the naive T cells (Figure 2B).
T67 2808-2971 Sentence denotes Because IL-4 is the key Th2 cytokine, the expression of IL-4 and FOXP3 in freshly isolated CD4+ T cells was analyzed by fluorescence activated cell sorting (FACS).
T68 2972-3094 Sentence denotes IL-4–expressing cells were most abundant among CD45RO+CD25– cells, which did not co-express FOXP3 (Figure 3A, left panel).
T69 3095-3199 Sentence denotes In contrast, CD45RO+CD25+ cells abundantly expressed FOXP3, while lacking IL-4 (Figure 3A, right panel).
T70 3200-3320 Sentence denotes As shown in Figure 3B, the frequency of the IL-4+ cells was always below 1% in the FOXP3+ cells close to the background.
T71 3321-3456 Sentence denotes The IL-4+ cells were confined to the FOXP3– cells, as shown for the CD45RO+CD25–, CD45RO+CD25+, and CD45RO+CD25+high cells (Figure 3B).
T72 3457-3556 Sentence denotes In addition, neither the Th2 clone (BR8) nor CRTH2 cells significantly expressed FOXP3 (Figure 3C).
T73 3557-3729 Sentence denotes Cells enriched for their IL-4 secretion using the magnetic cell isolation technology contained some FOXP3-expressing cells, but importantly, the expression did not overlap.
T74 3730-3845 Sentence denotes Taken together, these data indicate that FOXP3 was not expressed by Th2 cells and was not inducible in those cells.
T75 3846-3886 Sentence denotes Figure 2 Th2 Cells Do Not Express FOXP3
T76 3887-4064 Sentence denotes (A) Intracellular FACS analysis of FOXP3 expression in Th1, Th2, or iTreg-differentiated cells (two rounds, phenotype see Figure S1), rested or activated, with or without TGF-β.
T77 4065-4116 Sentence denotes FOXP3 expression was measured after 5 d in culture.
T78 4117-4183 Sentence denotes The dot blots are representative of three independent experiments.
T79 4184-4271 Sentence denotes (B) Shows the same experimental setup, but naturally occurring Th2 cells were analyzed.
T80 4272-4329 Sentence denotes Data are representative of three independent experiments.
T81 4330-4379 Sentence denotes Figure 3 Th2- or IL-4–Producing Cells Lack FOXP3
T82 4380-4477 Sentence denotes (A) FACS analysis of intracellular FOXP3 and IL-4 expression following PMA/Ionomycin stimulation.
T83 4478-4715 Sentence denotes CD4+ T cells were gated on the basis of CD45RO and CD25 surface expression (upper panel), and gated cells are shown below for the CD45RO+CD25− (A, left panel), the CD45RO+CD25+ (right panel), and the CD45RO−CD25− subsets (central panel).
T84 4716-4825 Sentence denotes A statistical analysis of eight independent donors after subtraction of the isotype control are shown in (B).
T85 4826-4881 Sentence denotes The dotted gray line indicates the IC background level.
T86 4882-5059 Sentence denotes The error bars show the error of the mean. (C) Similarly, a Th2 clone (BR8), CRTH2+ Th2 cells, IL-4-secreting cells, and memory T cells (CD45RO) were stained for FOXP3 and IL-4.
T87 5060-5117 Sentence denotes Data are representative of three independent experiments.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T4838 0-5 Protein denotes FOXP3
T4839 6-15 Positive_regulation denotes Induction
T4840 53-58 Protein denotes FOXP3
T4841 59-69 Gene_expression denotes expression
T4842 77-84 Positive_regulation denotes induced
T4843 201-204 Protein denotes CD4
T4844 240-247 Gene_expression denotes express
T4845 248-253 Protein denotes FOXP3
T4846 278-283 Protein denotes FOXP3
T4847 291-300 Gene_expression denotes expressed true
T4848 328-338 Gene_expression denotes expression
T4849 342-352 Regulation denotes restricted true
T4850 376-381 Protein denotes FOXP3
T4851 382-397 Transcription denotes mRNA expression true
T4852 447-451 Protein denotes CD25
T4853 461-464 Protein denotes CD4
T4854 473-479 Protein denotes CD45RA
T4855 490-496 Protein denotes CD45RO
T4856 639-642 Protein denotes CD4
T4857 643-647 Protein denotes CD25
T4858 650-656 Protein denotes CD45RA
T4859 659-665 Protein denotes CD45RO
T4860 672-675 Protein denotes CD4
T4861 676-682 Protein denotes CD45RO
T4862 683-687 Protein denotes CD25
T4863 716-722 Positive_regulation denotes induce
T4864 723-728 Protein denotes FOXP3
T4865 784-789 Protein denotes TGF-β
T4866 901-909 Positive_regulation denotes increase true
T4867 910-915 Protein denotes FOXP3
T4868 916-926 Gene_expression denotes expression
T4869 986-997 Positive_regulation denotes up-regulate
T4870 998-1003 Protein denotes FOXP3
T4871 1696-1703 Gene_expression denotes produce
T4872 1704-1708 Protein denotes IL-4
T4873 1750-1755 Protein denotes TGF-β
T4874 1775-1782 Negative_regulation denotes prevent true
T4875 1783-1788 Protein denotes FOXP3
T4876 1789-1798 Positive_regulation denotes induction
T4877 1813-1827 Negative_regulation denotes neutralization
T4878 1831-1835 Protein denotes IL-4
T4879 1852-1856 Protein denotes IL-4
T4880 1874-1880 Positive_regulation denotes rescue true
T4881 1881-1886 Protein denotes FOXP3
T4882 1887-1897 Gene_expression denotes expression
T4883 2016-2023 Gene_expression denotes express
T4884 2024-2029 Protein denotes FOXP3
T4885 2047-2056 Negative_regulation denotes inability
T4886 2073-2080 Gene_expression denotes express
T4887 2081-2086 Protein denotes FOXP3
T4888 2159-2163 Negative_regulation denotes lack
T4889 2164-2169 Protein denotes FOXP3
T4890 2170-2180 Gene_expression denotes expression
T4891 2211-2220 Gene_expression denotes expressed
T4892 2221-2226 Protein denotes FOXP3
T4893 2302-2309 Gene_expression denotes express
T4894 2310-2315 Protein denotes FOXP3
T4895 2325-2328 Positive_regulation denotes low true
T4896 2329-2333 Protein denotes CD25
T4897 2342-2352 Gene_expression denotes expression
T4898 2375-2380 Protein denotes TGF-β
T4899 2397-2405 Positive_regulation denotes increase true
T4900 2410-2415 Protein denotes FOXP3
T4901 2416-2426 Gene_expression denotes expression
T4902 2464-2471 Positive_regulation denotes induced
T4903 2472-2477 Protein denotes FOXP3
T4904 2478-2488 Gene_expression denotes expression
T4905 2541-2546 Protein denotes CRTH2
T4906 2593-2597 Protein denotes IL-4
T4907 2598-2607 Gene_expression denotes secretion
T4908 2615-2619 Protein denotes IL-4
T4909 2620-2629 Gene_expression denotes producing
T4910 2659-2666 Negative_regulation denotes lacking
T4911 2667-2672 Protein denotes FOXP3
T4912 2673-2683 Gene_expression denotes expression
T4913 2709-2714 Protein denotes TGF-β
T4914 2724-2729 Protein denotes FOXP3
T4915 2730-2739 Positive_regulation denotes induction
T4916 2740-2746 Negative_regulation denotes failed
T4917 2816-2820 Protein denotes IL-4
T4918 2850-2860 Gene_expression denotes expression true
T4919 2850-2860 Gene_expression denotes expression true
T4920 2864-2868 Protein denotes IL-4
T4921 2873-2878 Protein denotes FOXP3
T4922 2899-2902 Protein denotes CD4
T4923 2972-2976 Protein denotes IL-4
T4924 2977-2987 Gene_expression denotes expressing
T4925 3019-3025 Protein denotes CD45RO
T4926 3026-3030 Protein denotes CD25
T4927 3053-3063 Gene_expression denotes co-express true
T4928 3064-3069 Protein denotes FOXP3
T4929 3108-3114 Protein denotes CD45RO
T4930 3115-3119 Protein denotes CD25
T4931 3138-3147 Gene_expression denotes expressed
T4932 3148-3153 Protein denotes FOXP3
T4933 3161-3168 Negative_regulation denotes lacking
T4934 3169-3173 Protein denotes IL-4
T4935 3244-3248 Protein denotes IL-4
T4936 3283-3288 Protein denotes FOXP3
T4937 3325-3329 Protein denotes IL-4
T4938 3358-3363 Protein denotes FOXP3
T4939 3389-3395 Protein denotes CD45RO
T4940 3396-3400 Protein denotes CD25
T4941 3403-3409 Protein denotes CD45RO
T4942 3410-3414 Protein denotes CD25
T4943 3421-3427 Protein denotes CD45RO
T4944 3428-3432 Protein denotes CD25
T4945 3502-3507 Protein denotes CRTH2
T4946 3528-3537 Gene_expression denotes expressed
T4947 3538-3543 Protein denotes FOXP3
T4948 3582-3586 Protein denotes IL-4
T4949 3587-3596 Gene_expression denotes secretion
T4950 3657-3662 Protein denotes FOXP3
T4951 3663-3673 Gene_expression denotes expressing
T4952 3771-3776 Protein denotes FOXP3
T4953 3785-3794 Gene_expression denotes expressed true
T4954 3820-3829 Positive_regulation denotes inducible true
T23765 1120-1126 Positive_regulation denotes Induce true
T23766 1127-1132 Protein denotes FOXP3
T23767 1133-1143 Gene_expression denotes Expression
T23768 1199-1202 Protein denotes CD3
T23769 1203-1207 Protein denotes CD28
T23770 1224-1229 Protein denotes TGF-β
T23771 1303-1308 Protein denotes FOXP3
T23772 1479-1482 Protein denotes CD3
T23773 1483-1487 Protein denotes CD28
T23774 1489-1494 Protein denotes TGF-β
T23775 1504-1508 Protein denotes IL-4
T24033 3873-3880 Gene_expression denotes Express true
T24034 3881-3886 Protein denotes FOXP3
T24035 3922-3927 Protein denotes FOXP3
T24036 3928-3938 Gene_expression denotes expression true
T24037 4058-4063 Protein denotes TGF-β
T24038 4065-4070 Protein denotes FOXP3
T24039 4071-4081 Gene_expression denotes expression true
T24593 4348-4352 Protein denotes IL-4
T24594 4353-4362 Gene_expression denotes Producing
T24595 4369-4373 Negative_regulation denotes Lack
T24596 4374-4379 Protein denotes FOXP3
T24597 4415-4420 Protein denotes FOXP3
T24598 4425-4429 Protein denotes IL-4
T24599 4430-4440 Gene_expression denotes expression true
T24600 4430-4440 Gene_expression denotes expression true
T24601 4478-4481 Protein denotes CD4
T24602 4518-4524 Protein denotes CD45RO
T24603 4529-4533 Protein denotes CD25
T24604 4542-4552 Gene_expression denotes expression
T24605 4542-4552 Gene_expression denotes expression
T24606 4608-4614 Protein denotes CD45RO
T24607 4615-4619 Protein denotes CD25
T24608 4642-4648 Protein denotes CD45RO
T24609 4649-4653 Protein denotes CD25
T24610 4678-4684 Protein denotes CD45RO
T24611 4685-4689 Protein denotes CD25
T24612 4959-4964 Protein denotes CRTH2
T24613 4977-4981 Protein denotes IL-4
T24614 4982-4991 Gene_expression denotes secreting
T24615 5019-5025 Protein denotes CD45RO
T24616 5032-5039 Gene_expression denotes stained
T24617 5032-5039 Gene_expression denotes stained
T24618 5044-5049 Protein denotes FOXP3
T24619 5054-5058 Protein denotes IL-4
R3817 T4838 T4839 themeOf FOXP3,Induction
R3822 T4840 T4841 themeOf FOXP3,expression
R3824 T4841 T4842 themeOf expression,induced
R3825 T4845 T4844 themeOf FOXP3,express
R3826 T4846 T4847 themeOf FOXP3,expressed
R3827 T4846 T4848 themeOf FOXP3,expression
R3828 T4848 T4849 themeOf expression,restricted
R3829 T4889 T4890 themeOf FOXP3,expression
R3830 T4850 T4851 themeOf FOXP3,mRNA expression
R3831 T4890 T4888 themeOf expression,lack
R3832 T4892 T4891 themeOf FOXP3,expressed
R3833 T4864 T4863 themeOf FOXP3,induce
R3834 T4894 T4893 themeOf FOXP3,express
R3835 T4896 T4897 themeOf CD25,expression
R3836 T4897 T4895 themeOf expression,low
R3837 T4898 T4899 causeOf TGF-β,increase
R3838 T4900 T4901 themeOf FOXP3,expression
R3839 T4901 T4899 themeOf expression,increase
R3840 T4903 T4904 themeOf FOXP3,expression
R3841 T4904 T4902 themeOf expression,induced
R3842 T4906 T4907 themeOf IL-4,secretion
R3843 T4908 T4909 themeOf IL-4,producing
R3844 T4865 T4863 causeOf TGF-β,induce
R3845 T4911 T4912 themeOf FOXP3,expression
R3846 T4912 T4910 themeOf expression,lacking
R3847 T4913 T4915 causeOf TGF-β,induction
R3848 T4867 T4868 themeOf FOXP3,expression
R3849 T4914 T4915 themeOf FOXP3,induction
R3850 T4915 T4916 themeOf induction,failed
R3851 T4868 T4866 themeOf expression,increase
R3852 T4920 T4918 themeOf IL-4,expression
R3853 T4870 T4869 themeOf FOXP3,up-regulate
R3854 T4921 T4919 themeOf FOXP3,expression
R3855 T4923 T4924 themeOf IL-4,expressing
R3856 T4872 T4871 themeOf IL-4,produce
R3857 T4872 T4874 causeOf IL-4,prevent
R3858 T4928 T4927 themeOf FOXP3,co-express
R3859 T4875 T4876 themeOf FOXP3,induction
R3860 T4932 T4931 themeOf FOXP3,expressed
R3861 T4934 T4933 themeOf IL-4,lacking
R3862 T4876 T4874 themeOf induction,prevent
R3863 T4877 T4880 causeOf neutralization,rescue
R3864 T4878 T4877 themeOf IL-4,neutralization
R3865 T4881 T4882 themeOf FOXP3,expression
R3866 T4947 T4946 themeOf FOXP3,expressed
R3867 T4882 T4880 themeOf expression,rescue
R3868 T4884 T4883 themeOf FOXP3,express
R3869 T4948 T4949 themeOf IL-4,secretion
R3870 T4886 T4885 themeOf express,inability
R3871 T4950 T4951 themeOf FOXP3,expressing
R3872 T4952 T4953 themeOf FOXP3,expressed
R3873 T4952 T4954 themeOf FOXP3,inducible
R3874 T4887 T4886 themeOf FOXP3,express
R17831 T23766 T23767 themeOf FOXP3,Expression
R17832 T23767 T23765 themeOf Expression,Induce
R18032 T24034 T24033 themeOf FOXP3,Express
R18033 T24035 T24036 themeOf FOXP3,expression
R18034 T24038 T24039 themeOf FOXP3,expression
R18410 T24593 T24594 themeOf IL-4,Producing
R18411 T24596 T24595 themeOf FOXP3,Lack
R18412 T24597 T24599 themeOf FOXP3,expression
R18413 T24598 T24600 themeOf IL-4,expression
R18414 T24602 T24604 themeOf CD45RO,expression
R18415 T24603 T24605 themeOf CD25,expression
R18416 T24613 T24614 themeOf IL-4,secreting
R18417 T24618 T24616 themeOf FOXP3,stained
R18418 T24619 T24617 themeOf IL-4,stained

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T23721 1194-1202 Protein denotes anti-CD3
T23722 1203-1207 Protein denotes CD28
T23723 1224-1229 Protein denotes TGF-β
T23724 1303-1313 Protein denotes FOXP3 mRNA
T23725 1474-1482 Protein denotes anti-CD3
T23726 1483-1487 Protein denotes CD28
T23727 1489-1494 Protein denotes TGF-β
T23728 1499-1508 Protein denotes anti-IL-4
T24006 3947-3950 Protein denotes Th2
T24007 4058-4063 Protein denotes TGF-β
T24008 3928-3938 Gene_expression denotes expression
T24009 3928-3938 Gene_expression denotes expression
T24010 3928-3938 Gene_expression denotes expression
T24011 4065-4070 Protein denotes FOXP3
T24012 4071-4081 Gene_expression denotes expression
T24506 4415-4420 Protein denotes FOXP3
T24507 4425-4429 Protein denotes IL-4
T24508 4430-4440 Gene_expression denotes expression
T24509 4430-4440 Gene_expression denotes expression
T24510 4478-4482 Protein denotes CD4+
T24511 4518-4524 Protein denotes CD45RO
T24512 4529-4541 Protein denotes CD25 surface
T24513 4608-4614 Protein denotes CD45RO
T24514 4615-4619 Protein denotes CD25
T24515 4678-4684 Protein denotes CD45RO
T24516 4685-4689 Protein denotes CD25
T24517 4542-4552 Gene_expression denotes expression
T24518 4542-4552 Gene_expression denotes expression
T24519 5044-5049 Protein denotes FOXP3
T24520 5054-5058 Protein denotes IL-4
T24521 5032-5039 Gene_expression denotes stained
T24522 5032-5039 Gene_expression denotes stained
T24004 3922-3927 Protein denotes FOXP3
T24005 3942-3945 Protein denotes Th1
R18019 T24004 T24008 themeOf FOXP3,expression
R18020 T24005 T24009 themeOf Th1,expression
R18021 T24006 T24010 themeOf Th2,expression
R18022 T24011 T24012 themeOf FOXP3,expression
R18383 T24506 T24508 themeOf FOXP3,expression
R18384 T24507 T24509 themeOf IL-4,expression
R18385 T24511 T24517 themeOf CD45RO,expression
R18386 T24512 T24518 themeOf CD25 surface,expression
R18387 T24519 T24521 themeOf FOXP3,stained
R18388 T24520 T24522 themeOf IL-4,stained

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T2899 6-15 Positive_regulation denotes Induction
T2900 901-909 Positive_regulation denotes increase true
T2901 916-926 Gene_expression denotes expression
T2902 986-997 Positive_regulation denotes up-regulate
T2903 1696-1703 Gene_expression denotes produce
T2904 1775-1782 Negative_regulation denotes prevent true
T2905 1789-1798 Positive_regulation denotes induction
T2906 1813-1827 Negative_regulation denotes neutralization
T2907 1874-1880 Positive_regulation denotes rescue true
T2908 1887-1897 Gene_expression denotes expression
T2909 2016-2023 Gene_expression denotes express
T2910 59-69 Gene_expression denotes expression
T2911 2047-2056 Negative_regulation denotes inability
T2912 2073-2080 Gene_expression denotes express
T2913 2159-2163 Negative_regulation denotes lack
T2914 2170-2180 Gene_expression denotes expression
T2915 2211-2220 Gene_expression denotes expressed
T2916 2302-2309 Gene_expression denotes express
T2917 2325-2328 Positive_regulation denotes low true
T2918 2342-2352 Gene_expression denotes expression
T2919 2397-2405 Positive_regulation denotes increase true
T2920 2416-2426 Gene_expression denotes expression
T2921 77-84 Positive_regulation denotes induced
T2922 2464-2471 Positive_regulation denotes induced
T2923 2478-2488 Gene_expression denotes expression
T2924 2598-2607 Gene_expression denotes secretion
T2925 2620-2629 Gene_expression denotes producing
T2926 2659-2666 Negative_regulation denotes lacking
T2927 2673-2683 Gene_expression denotes expression
T2928 2730-2739 Positive_regulation denotes induction
T2929 2740-2746 Negative_regulation denotes failed
T2930 2850-2860 Gene_expression denotes expression true
T2931 2850-2860 Gene_expression denotes expression true
T2932 240-247 Gene_expression denotes express
T2933 2977-2987 Gene_expression denotes expressing
T2934 3053-3063 Gene_expression denotes co-express true
T2935 3138-3147 Gene_expression denotes expressed
T2936 3161-3168 Negative_regulation denotes lacking
T2937 3528-3537 Gene_expression denotes expressed
T2938 3587-3596 Gene_expression denotes secretion
T2939 3663-3673 Gene_expression denotes expressing
T2940 3785-3794 Gene_expression denotes expressed true
T2941 3820-3829 Positive_regulation denotes inducible true
T2942 291-300 Gene_expression denotes expressed true
T2943 328-338 Gene_expression denotes expression
T2944 342-352 Regulation denotes restricted true
T2945 382-397 Transcription denotes mRNA expression true
T2946 716-722 Positive_regulation denotes induce
T2947 0-5 Protein denotes FOXP3
T2948 490-496 Protein denotes CD45RO
T2949 639-642 Protein denotes CD4
T2950 643-647 Protein denotes CD25
T2951 650-656 Protein denotes CD45RA
T2952 659-665 Protein denotes CD45RO
T2953 672-675 Protein denotes CD4
T2954 676-682 Protein denotes CD45RO
T2955 683-687 Protein denotes CD25
T2956 723-728 Protein denotes FOXP3
T2957 784-789 Protein denotes TGF-β
T2958 53-58 Protein denotes FOXP3
T2959 910-915 Protein denotes FOXP3
T2960 998-1003 Protein denotes FOXP3
T2961 1704-1708 Protein denotes IL-4
T2962 1750-1755 Protein denotes TGF-β
T2963 1783-1788 Protein denotes FOXP3
T2964 1831-1835 Protein denotes IL-4
T2965 1852-1856 Protein denotes IL-4
T2966 1881-1886 Protein denotes FOXP3
T2967 2024-2029 Protein denotes FOXP3
T2968 2081-2086 Protein denotes FOXP3
T2969 201-204 Protein denotes CD4
T2970 2164-2169 Protein denotes FOXP3
T2971 2221-2226 Protein denotes FOXP3
T2972 2310-2315 Protein denotes FOXP3
T2973 2329-2333 Protein denotes CD25
T2974 2375-2380 Protein denotes TGF-β
T2975 2410-2415 Protein denotes FOXP3
T2976 2472-2477 Protein denotes FOXP3
T2977 2541-2546 Protein denotes CRTH2
T2978 2593-2597 Protein denotes IL-4
T2979 2615-2619 Protein denotes IL-4
T2980 248-253 Protein denotes FOXP3
T2981 2667-2672 Protein denotes FOXP3
T2982 2724-2729 Protein denotes FOXP3
T2983 2816-2820 Protein denotes IL-4
T2984 2864-2868 Protein denotes IL-4
T2985 2873-2878 Protein denotes FOXP3
T2986 2899-2902 Protein denotes CD4
T2987 2972-2976 Protein denotes IL-4
T2988 3019-3025 Protein denotes CD45RO
T2989 3026-3030 Protein denotes CD25
T2990 278-283 Protein denotes FOXP3
T2991 3064-3069 Protein denotes FOXP3
T2992 3108-3114 Protein denotes CD45RO
T2993 3115-3119 Protein denotes CD25
T2994 3148-3153 Protein denotes FOXP3
T2995 3169-3173 Protein denotes IL-4
T2996 3244-3248 Protein denotes IL-4
T2997 3283-3288 Protein denotes FOXP3
T2998 3325-3329 Protein denotes IL-4
T2999 3358-3363 Protein denotes FOXP3
T3000 3389-3395 Protein denotes CD45RO
T3001 376-381 Protein denotes FOXP3
T3002 3396-3400 Protein denotes CD25
T3003 3403-3409 Protein denotes CD45RO
T3004 3410-3414 Protein denotes CD25
T3005 3421-3427 Protein denotes CD45RO
T3006 3428-3432 Protein denotes CD25
T3007 3502-3507 Protein denotes CRTH2
T3008 3538-3543 Protein denotes FOXP3
T3009 3582-3586 Protein denotes IL-4
T3010 3657-3662 Protein denotes FOXP3
T3011 3771-3776 Protein denotes FOXP3
T3012 447-451 Protein denotes CD25
T3013 461-464 Protein denotes CD4
T3014 473-479 Protein denotes CD45RA
T3015 2709-2714 Protein denotes TGF-β
T23452 1303-1308 Protein denotes FOXP3
T23453 1479-1482 Protein denotes CD3
T23454 1483-1487 Protein denotes CD28
T23455 1489-1494 Protein denotes TGF-β
T23456 1504-1508 Protein denotes IL-4
T24110 4542-4552 Gene_expression denotes expression
T24111 4608-4614 Protein denotes CD45RO
T24112 4615-4619 Protein denotes CD25
T24113 4642-4648 Protein denotes CD45RO
T24114 4649-4653 Protein denotes CD25
T24115 4678-4684 Protein denotes CD45RO
T24116 4685-4689 Protein denotes CD25
T24117 4959-4964 Protein denotes CRTH2
T24118 4977-4981 Protein denotes IL-4
T24119 4982-4991 Gene_expression denotes secreting
T24120 5019-5025 Protein denotes CD45RO
T24121 5032-5039 Gene_expression denotes stained
T24122 5032-5039 Gene_expression denotes stained
T24123 5044-5049 Protein denotes FOXP3
T24124 5054-5058 Protein denotes IL-4
T23801 3873-3880 Gene_expression denotes Express true
T23802 3881-3886 Protein denotes FOXP3
T23803 3922-3927 Protein denotes FOXP3
T23804 3928-3938 Gene_expression denotes expression true
T23805 4058-4063 Protein denotes TGF-β
T23806 4065-4070 Protein denotes FOXP3
T23807 4071-4081 Gene_expression denotes expression true
T23446 1120-1126 Positive_regulation denotes Induce true
T23447 1127-1132 Protein denotes FOXP3
T23448 1133-1143 Gene_expression denotes Expression
T23449 1199-1202 Protein denotes CD3
T23450 1203-1207 Protein denotes CD28
T23451 1224-1229 Protein denotes TGF-β
T24098 4348-4352 Protein denotes IL-4
T24099 4353-4362 Gene_expression denotes Producing
T24100 4369-4373 Negative_regulation denotes Lack
T24101 4374-4379 Protein denotes FOXP3
T24102 4415-4420 Protein denotes FOXP3
T24103 4425-4429 Protein denotes IL-4
T24104 4430-4440 Gene_expression denotes expression true
T24105 4430-4440 Gene_expression denotes expression true
T24106 4478-4481 Protein denotes CD4
T24107 4518-4524 Protein denotes CD45RO
T24108 4529-4533 Protein denotes CD25
T24109 4542-4552 Gene_expression denotes expression
R2316 T2910 T2921 themeOf expression,induced
R2317 T2912 T2911 themeOf express,inability
R2318 T2914 T2913 themeOf expression,lack
R2319 T2918 T2917 themeOf expression,low
R2320 T2920 T2919 themeOf expression,increase
R2321 T2923 T2922 themeOf expression,induced
R2322 T2927 T2926 themeOf expression,lacking
R2323 T2928 T2929 themeOf induction,failed
R2324 T2943 T2944 themeOf expression,restricted
R2326 T2956 T2946 themeOf FOXP3,induce
R2335 T2966 T2908 themeOf FOXP3,expression
R2336 T2967 T2909 themeOf FOXP3,express
R2337 T2968 T2912 themeOf FOXP3,express
R2338 T2970 T2914 themeOf FOXP3,expression
R2339 T2971 T2915 themeOf FOXP3,expressed
R2340 T2972 T2916 themeOf FOXP3,express
R2341 T2973 T2918 themeOf CD25,expression
R2342 T2974 T2919 causeOf TGF-β,increase
R2343 T2975 T2920 themeOf FOXP3,expression
R2344 T2976 T2923 themeOf FOXP3,expression
R2345 T2978 T2924 themeOf IL-4,secretion
R2346 T2979 T2925 themeOf IL-4,producing
R2347 T2980 T2932 themeOf FOXP3,express
R2348 T2981 T2927 themeOf FOXP3,expression
R2349 T2982 T2928 themeOf FOXP3,induction
R2350 T2984 T2930 themeOf IL-4,expression
R2351 T2985 T2931 themeOf FOXP3,expression
R2352 T2987 T2933 themeOf IL-4,expressing
R2353 T2990 T2942 themeOf FOXP3,expressed
R2354 T2990 T2943 themeOf FOXP3,expression
R2355 T2991 T2934 themeOf FOXP3,co-express
R2356 T2994 T2935 themeOf FOXP3,expressed
R2357 T2995 T2936 themeOf IL-4,lacking
R2358 T3001 T2945 themeOf FOXP3,mRNA expression
R2359 T3008 T2937 themeOf FOXP3,expressed
R2360 T3009 T2938 themeOf IL-4,secretion
R2361 T3010 T2939 themeOf FOXP3,expressing
R2362 T3011 T2940 themeOf FOXP3,expressed
R2363 T3011 T2941 themeOf FOXP3,inducible
R2364 T3015 T2928 causeOf TGF-β,induction
R17841 T23802 T23801 themeOf FOXP3,Express
R17842 T23803 T23804 themeOf FOXP3,expression
R17843 T23806 T23807 themeOf FOXP3,expression
R17593 T23447 T23448 themeOf FOXP3,Expression
R17594 T23448 T23446 themeOf Expression,Induce
R18053 T24098 T24099 themeOf IL-4,Producing
R18054 T24101 T24100 themeOf FOXP3,Lack
R18055 T24102 T24104 themeOf FOXP3,expression
R18056 T24103 T24105 themeOf IL-4,expression
R18057 T24107 T24109 themeOf CD45RO,expression
R18058 T24108 T24110 themeOf CD25,expression
R18059 T24118 T24119 themeOf IL-4,secreting
R18060 T24123 T24121 themeOf FOXP3,stained
R18061 T24124 T24122 themeOf IL-4,stained
R2312 T2901 T2900 themeOf expression,increase
R2313 T2905 T2904 themeOf induction,prevent
R2314 T2906 T2907 causeOf neutralization,rescue
R2315 T2908 T2907 themeOf expression,rescue
R2325 T2947 T2899 themeOf FOXP3,Induction
R2327 T2957 T2946 causeOf TGF-β,induce
R2328 T2958 T2910 themeOf FOXP3,expression
R2329 T2959 T2901 themeOf FOXP3,expression
R2330 T2960 T2902 themeOf FOXP3,up-regulate
R2331 T2961 T2903 themeOf IL-4,produce
R2332 T2961 T2904 causeOf IL-4,prevent
R2333 T2963 T2905 themeOf FOXP3,induction
R2334 T2964 T2906 themeOf IL-4,neutralization

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T3595 0-5 Q9BZS1 denotes FOXP3
T3596 53-58 Q9BZS1 denotes FOXP3
T3597 201-204 P01730 denotes CD4
T3598 248-253 Q9BZS1 denotes FOXP3
T3599 278-283 Q9BZS1 denotes FOXP3
T3600 376-381 Q9BZS1 denotes FOXP3
T3601 447-451 P01589 denotes CD25
T3602 461-464 P01730 denotes CD4
T3603 473-479 P08575 denotes CD45RA
T3604 490-496 P08575 denotes CD45RO
T3605 639-642 P01730 denotes CD4
T3606 643-647 P01589 denotes CD25
T3607 650-656 P08575 denotes CD45RA
T3608 659-665 P08575 denotes CD45RO
T3609 672-675 P01730 denotes CD4
T3610 676-682 P08575 denotes CD45RO
T3611 683-687 P01589 denotes CD25
T3612 694-698 P00519 denotes able
T3613 723-728 Q9BZS1 denotes FOXP3
T3614 784-789 P01137 denotes TGF-β
T3615 910-915 Q9BZS1 denotes FOXP3
T3616 998-1003 Q9BZS1 denotes FOXP3
T3617 1704-1708 P05112 denotes IL-4
T3618 1750-1755 P01137 denotes TGF-β
T3619 1783-1788 Q9BZS1 denotes FOXP3
T3620 1831-1835 P05112 denotes IL-4
T3621 1852-1856 P05112 denotes IL-4
T3622 1881-1886 Q9BZS1 denotes FOXP3
T3623 2024-2029 Q9BZS1 denotes FOXP3
T3624 2081-2086 Q9BZS1 denotes FOXP3
T3625 2164-2169 Q9BZS1 denotes FOXP3
T3626 2221-2226 Q9BZS1 denotes FOXP3
T3627 2310-2315 Q9BZS1 denotes FOXP3
T3628 2329-2333 P01589 denotes CD25
T3629 2375-2380 P01137 denotes TGF-β
T3630 2410-2415 Q9BZS1 denotes FOXP3
T3631 2472-2477 Q9BZS1 denotes FOXP3
T3632 2593-2597 P05112 denotes IL-4
T3633 2615-2619 P05112 denotes IL-4
T3634 2667-2672 Q9BZS1 denotes FOXP3
T3635 2709-2714 P01137 denotes TGF-β
T3636 2724-2729 Q9BZS1 denotes FOXP3
T3637 2816-2820 P05112 denotes IL-4
T3638 2864-2868 P05112 denotes IL-4
T3639 2873-2878 Q9BZS1 denotes FOXP3
T3640 2899-2902 P01730 denotes CD4
T3641 2972-2976 P05112 denotes IL-4
T3642 3019-3025 P08575 denotes CD45RO
T3643 3026-3030 P01589 denotes CD25
T3644 3064-3069 Q9BZS1 denotes FOXP3
T3645 3108-3114 P08575 denotes CD45RO
T3646 3115-3119 P01589 denotes CD25
T3647 3148-3153 Q9BZS1 denotes FOXP3
T3648 3169-3173 P05112 denotes IL-4
T3649 3244-3248 P05112 denotes IL-4
T3650 3283-3288 Q9BZS1 denotes FOXP3
T3651 3325-3329 P05112 denotes IL-4
T3652 3358-3363 Q9BZS1 denotes FOXP3
T3653 3389-3395 P08575 denotes CD45RO
T3654 3396-3400 P01589 denotes CD25
T3655 3403-3409 P08575 denotes CD45RO
T3656 3410-3414 P01589 denotes CD25
T3657 3421-3427 P08575 denotes CD45RO
T3658 3428-3432 P01589 denotes CD25
T3659 3538-3543 Q9BZS1 denotes FOXP3
T3660 3582-3586 P05112 denotes IL-4
T3661 3657-3662 Q9BZS1 denotes FOXP3
T3662 3771-3776 Q9BZS1 denotes FOXP3
T23569 1127-1132 Q9BZS1 denotes FOXP3
T23570 1199-1202 P04234 denotes CD3
T23571 1199-1202 P20963 denotes CD3
T23572 1199-1202 P09693 denotes CD3
T23573 1199-1202 P07766 denotes CD3
T23574 1203-1207 P10747 denotes CD28
T23575 1224-1229 P01137 denotes TGF-β
T23576 1303-1308 Q9BZS1 denotes FOXP3
T23577 1479-1482 P09693 denotes CD3
T23578 1479-1482 P20963 denotes CD3
T23579 1479-1482 P07766 denotes CD3
T23580 1479-1482 P04234 denotes CD3
T23581 1483-1487 P10747 denotes CD28
T23582 1489-1494 P01137 denotes TGF-β
T23583 1504-1508 P05112 denotes IL-4
T23897 3881-3886 Q9BZS1 denotes FOXP3
T23898 3922-3927 Q9BZS1 denotes FOXP3
T23899 4058-4063 P01137 denotes TGF-β
T23900 4065-4070 Q9BZS1 denotes FOXP3
T24279 4348-4352 P05112 denotes IL-4
T24280 4374-4379 Q9BZS1 denotes FOXP3
T24281 4415-4420 Q9BZS1 denotes FOXP3
T24282 4425-4429 P05112 denotes IL-4
T24283 4478-4481 P01730 denotes CD4
T24284 4518-4524 P08575 denotes CD45RO
T24285 4529-4533 P01589 denotes CD25
T24286 4608-4614 P08575 denotes CD45RO
T24287 4615-4619 P01589 denotes CD25
T24288 4642-4648 P08575 denotes CD45RO
T24289 4649-4653 P01589 denotes CD25
T24290 4678-4684 P08575 denotes CD45RO
T24291 4685-4689 P01589 denotes CD25
T24292 4977-4981 P05112 denotes IL-4
T24293 5019-5025 P08575 denotes CD45RO
T24294 5044-5049 Q9BZS1 denotes FOXP3
T24295 5054-5058 P05112 denotes IL-4

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T2744 0-5 Protein denotes FOXP3
T2745 6-15 Positive_regulation denotes Induction
T2746 53-58 Protein denotes FOXP3
T2747 59-69 Gene_expression denotes expression
T2748 77-84 Positive_regulation denotes induced true
T2749 201-204 Protein denotes CD4
T2750 240-247 Gene_expression denotes express true
T2751 248-253 Protein denotes FOXP3 true
T2752 278-283 Protein denotes FOXP3
T2753 291-300 Gene_expression denotes expressed true
T2754 328-338 Gene_expression denotes expression
T2755 376-381 Protein denotes FOXP3
T2756 382-397 Transcription denotes mRNA expression
T2757 447-451 Protein denotes CD25 true
T2758 461-464 Protein denotes CD4
T2759 473-479 Protein denotes CD45RA
T2760 490-496 Protein denotes CD45RO true
T2761 639-642 Protein denotes CD4
T2762 643-647 Protein denotes CD25
T2763 650-656 Protein denotes CD45RA
T2764 659-665 Protein denotes CD45RO
T2765 672-675 Protein denotes CD4
T2766 676-682 Protein denotes CD45RO
T2767 683-687 Protein denotes CD25
T2768 716-722 Positive_regulation denotes induce
T2769 723-728 Protein denotes FOXP3 true
T2770 734-739 Positive_regulation denotes up to
T2771 784-789 Protein denotes TGF-β true
T2772 901-909 Positive_regulation denotes increase
T2773 910-915 Protein denotes FOXP3
T2774 916-926 Gene_expression denotes expression
T2775 986-997 Positive_regulation denotes up-regulate
T2776 998-1003 Protein denotes FOXP3
T2777 1696-1703 Gene_expression denotes produce
T2778 1704-1708 Protein denotes IL-4
T2779 1714-1724 Positive_regulation denotes activation
T2780 1736-1744 Binding denotes interact
T2781 1750-1755 Protein denotes TGF-β true
T2782 1775-1782 Negative_regulation denotes prevent true
T2783 1783-1788 Protein denotes FOXP3
T2784 1789-1798 Positive_regulation denotes induction true
T2785 1813-1827 Negative_regulation denotes neutralization
T2786 1831-1835 Protein denotes IL-4
T2787 1843-1851 Negative_regulation denotes blocking
T2788 1852-1856 Protein denotes IL-4
T2789 1874-1880 Positive_regulation denotes rescue
T2790 1881-1886 Protein denotes FOXP3 true
T2791 1887-1897 Gene_expression denotes expression true
T2792 2016-2023 Gene_expression denotes express
T2793 2024-2029 Protein denotes FOXP3
T2794 2073-2080 Gene_expression denotes express
T2795 2081-2086 Protein denotes FOXP3
T2796 2159-2163 Negative_regulation denotes lack
T2797 2164-2169 Protein denotes FOXP3
T2798 2170-2180 Gene_expression denotes expression
T2799 2211-2220 Gene_expression denotes expressed
T2800 2221-2226 Protein denotes FOXP3
T2801 2302-2309 Gene_expression denotes express
T2802 2310-2315 Protein denotes FOXP3
T2803 2325-2328 Positive_regulation denotes low
T2804 2329-2333 Protein denotes CD25
T2805 2342-2352 Gene_expression denotes expression
T2806 2375-2380 Protein denotes TGF-β
T2807 2397-2405 Positive_regulation denotes increase
T2808 2410-2415 Protein denotes FOXP3
T2809 2416-2426 Gene_expression denotes expression
T2810 2464-2471 Positive_regulation denotes induced
T2811 2472-2477 Protein denotes FOXP3
T2812 2478-2488 Gene_expression denotes expression
T2813 2541-2546 Protein denotes CRTH2
T2814 2593-2597 Protein denotes IL-4
T2815 2598-2607 Gene_expression denotes secretion
T2816 2615-2619 Protein denotes IL-4
T2817 2620-2629 Gene_expression denotes producing
T2818 2659-2666 Negative_regulation denotes lacking
T2819 2667-2672 Protein denotes FOXP3
T2820 2673-2683 Gene_expression denotes expression
T2821 2709-2714 Protein denotes TGF-β
T2822 2715-2723 Positive_regulation denotes mediated
T2823 2724-2729 Protein denotes FOXP3
T2824 2730-2739 Positive_regulation denotes induction
T2825 2740-2746 Negative_regulation denotes failed
T2826 2816-2820 Protein denotes IL-4
T2827 2850-2860 Gene_expression denotes expression
T2828 2864-2868 Protein denotes IL-4
T2829 2873-2878 Protein denotes FOXP3
T2830 2899-2902 Protein denotes CD4
T2831 2972-2976 Protein denotes IL-4
T2832 2977-2987 Gene_expression denotes expressing
T2833 3019-3025 Protein denotes CD45RO
T2834 3026-3030 Protein denotes CD25
T2835 3053-3056 Gene_expression denotes co-
T2836 3056-3063 Gene_expression denotes express
T2837 3064-3069 Protein denotes FOXP3
T2838 3108-3114 Protein denotes CD45RO
T2839 3115-3119 Protein denotes CD25
T2840 3138-3147 Gene_expression denotes expressed
T2841 3148-3153 Protein denotes FOXP3
T2842 3161-3168 Negative_regulation denotes lacking
T2843 3169-3173 Protein denotes IL-4
T2844 3244-3248 Protein denotes IL-4
T2845 3283-3288 Protein denotes FOXP3
T2846 3325-3329 Protein denotes IL-4
T2847 3358-3363 Protein denotes FOXP3
T2848 3389-3395 Protein denotes CD45RO
T2849 3396-3400 Protein denotes CD25
T2850 3403-3409 Protein denotes CD45RO
T2851 3410-3414 Protein denotes CD25
T2852 3421-3427 Protein denotes CD45RO
T2853 3428-3432 Protein denotes CD25
T2854 3502-3507 Protein denotes CRTH2
T2855 3528-3537 Gene_expression denotes expressed
T2856 3538-3543 Protein denotes FOXP3
T2857 3582-3586 Protein denotes IL-4
T2858 3587-3596 Localization denotes secretion
T2859 3657-3662 Protein denotes FOXP3
T2860 3663-3673 Gene_expression denotes expressing
T2861 3702-3712 Gene_expression denotes expression
T2862 3771-3776 Protein denotes FOXP3
T2863 3785-3794 Gene_expression denotes expressed
T2864 3820-3829 Positive_regulation denotes inducible
T23439 1120-1126 Positive_regulation denotes Induce true
T23440 1127-1132 Protein denotes FOXP3
T23441 1133-1143 Gene_expression denotes Expression
T23442 1199-1202 Protein denotes CD3
T23443 1203-1207 Protein denotes CD28
T23444 1224-1229 Protein denotes TGF-β
T23445 1303-1308 Protein denotes FOXP3
T23794 3873-3880 Gene_expression denotes Express true
T23795 3881-3886 Protein denotes FOXP3 true
T23796 3922-3927 Protein denotes FOXP3 true
T23797 3928-3938 Gene_expression denotes expression
T23798 4058-4063 Protein denotes TGF-β
T23799 4065-4070 Protein denotes FOXP3
T23800 4071-4081 Gene_expression denotes expression
T24074 4348-4352 Protein denotes IL-4
T24075 4353-4362 Gene_expression denotes Producing
T24076 4369-4373 Negative_regulation denotes Lack true
T24077 4374-4379 Protein denotes FOXP3 true
T24078 4415-4420 Protein denotes FOXP3
T24079 4425-4429 Protein denotes IL-4
T24080 4430-4440 Gene_expression denotes expression
T24081 4441-4450 Positive_regulation denotes following
T24082 4478-4481 Protein denotes CD4
T24083 4518-4524 Protein denotes CD45RO
T24084 4529-4533 Protein denotes CD25
T24085 4542-4552 Gene_expression denotes expression
T24086 4608-4614 Protein denotes CD45RO
T24087 4615-4619 Protein denotes CD25
T24088 4642-4648 Protein denotes CD45RO
T24089 4649-4653 Protein denotes CD25
T24090 4678-4684 Protein denotes CD45RO
T24091 4685-4689 Protein denotes CD25
T24092 4959-4964 Protein denotes CRTH2
T24093 4977-4981 Protein denotes IL-4
T24094 5019-5025 Protein denotes CD45RO
T24095 5044-5049 Protein denotes FOXP3
T24096 5054-5058 Protein denotes IL-4
R2254 T2744 T2745 themeOf FOXP3,Induction
R2255 T2746 T2747 themeOf FOXP3,expression
R2256 T2747 T2748 themeOf expression,induced
R2257 T2751 T2750 themeOf FOXP3,express
R2258 T2752 T2753 themeOf FOXP3,expressed
R2259 T2752 T2754 themeOf FOXP3,expression
R2260 T2755 T2756 themeOf FOXP3,mRNA expression
R2261 T2769 T2768 themeOf FOXP3,induce
R2262 T2770 T2768 themeOf up to,induce
R2263 T2771 T2770 causeOf TGF-β,up to
R2264 T2773 T2774 themeOf FOXP3,expression
R2265 T2774 T2772 themeOf expression,increase
R2266 T2776 T2775 themeOf FOXP3,up-regulate
R2267 T2778 T2782 causeOf IL-4,prevent
R2268 T2778 T2777 themeOf IL-4,produce
R2269 T2778 T2780 themeOf IL-4,interact
R2270 T2780 T2782 causeOf interact,prevent
R2271 T2783 T2784 themeOf FOXP3,induction
R2272 T2784 T2782 themeOf induction,prevent
R2273 T2785 T2789 causeOf neutralization,rescue
R2274 T2786 T2785 themeOf IL-4,neutralization
R2275 T2790 T2791 themeOf FOXP3,expression
R2276 T2791 T2789 themeOf expression,rescue
R2277 T2793 T2792 themeOf FOXP3,express
R2278 T2795 T2794 themeOf FOXP3,express
R2279 T2797 T2798 themeOf FOXP3,expression
R2280 T2798 T2796 themeOf expression,lack
R2281 T2800 T2799 themeOf FOXP3,expressed
R2282 T2802 T2801 themeOf FOXP3,express
R2283 T2804 T2805 themeOf CD25,expression
R2284 T2805 T2803 themeOf expression,low
R2285 T2806 T2807 causeOf TGF-β,increase
R2286 T2808 T2809 themeOf FOXP3,expression
R2287 T2809 T2807 themeOf expression,increase
R2288 T2811 T2812 themeOf FOXP3,expression
R2289 T2812 T2810 themeOf expression,induced
R2290 T2814 T2815 themeOf IL-4,secretion
R2291 T2816 T2817 themeOf IL-4,producing
R2292 T2819 T2820 themeOf FOXP3,expression
R2293 T2820 T2818 themeOf expression,lacking
R2294 T2821 T2824 causeOf TGF-β,induction
R2295 T2821 T2825 causeOf TGF-β,failed
R2296 T2821 T2822 causeOf TGF-β,mediated
R2297 T2823 T2824 themeOf FOXP3,induction
R2298 T2824 T2822 themeOf induction,mediated
R2299 T2824 T2825 themeOf induction,failed
R2300 T2828 T2827 themeOf IL-4,expression
R2301 T2829 T2827 themeOf FOXP3,expression
R2302 T2831 T2832 themeOf IL-4,expressing
R2303 T2837 T2836 themeOf FOXP3,express
R2304 T2841 T2840 themeOf FOXP3,expressed
R2305 T2843 T2842 themeOf IL-4,lacking
R2306 T2856 T2855 themeOf FOXP3,expressed
R2307 T2857 T2858 themeOf IL-4,secretion
R2308 T2859 T2860 themeOf FOXP3,expressing
R2309 T2862 T2863 themeOf FOXP3,expressed
R2310 T2862 T2864 themeOf FOXP3,inducible
R2311 T2863 T2864 themeOf expressed,inducible
R17591 T23440 T23441 themeOf FOXP3,Expression
R17592 T23441 T23439 themeOf Expression,Induce
R17838 T23795 T23794 themeOf FOXP3,Express
R17839 T23796 T23797 themeOf FOXP3,expression
R17840 T23799 T23800 themeOf FOXP3,expression
R18047 T24074 T24075 themeOf IL-4,Producing
R18048 T24077 T24076 themeOf FOXP3,Lack
R18049 T24078 T24080 themeOf FOXP3,expression
R18050 T24079 T24080 themeOf IL-4,expression
R18051 T24083 T24085 themeOf CD45RO,expression
R18052 T24084 T24085 themeOf CD25,expression