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2_test

Id Subject Object Predicate Lexical cue
18162042-10626890-84704997 778-779 10626890 denotes 1
18162042-9846495-84704998 780-781 9846495 denotes 2
18162042-16467870-84704999 831-832 16467870 denotes 3
18162042-16467870-84705000 980-981 16467870 denotes 3
18162042-16520391-84705001 1233-1234 16520391 denotes 4
18162042-15662016-84705002 1235-1236 15662016 denotes 5
18162042-16489117-84705003 1334-1335 16489117 denotes 6
18162042-15634907-84705004 1411-1412 15634907 denotes 7
18162042-10549629-84705005 1468-1469 10549629 denotes 8
18162042-11390432-84705006 1524-1525 11390432 denotes 9
18162042-14676299-84705007 2277-2279 14676299 denotes 10
18162042-15753318-84705008 2447-2449 15753318 denotes 11
18162042-14597769-84705009 2450-2452 14597769 denotes 12
18162042-17185041-84705010 2512-2514 17185041 denotes 13
18162042-17154262-84705011 2515-2517 17154262 denotes 14
18162042-15809351-84705012 2713-2715 15809351 denotes 15
18162042-11045997-84705013 2785-2787 11045997 denotes 16
18162042-15809351-84705014 2898-2900 15809351 denotes 15
18162042-16973386-84705015 2901-2903 16973386 denotes 17
T91765 778-779 10626890 denotes 1
T15814 780-781 9846495 denotes 2
T97197 831-832 16467870 denotes 3
T83455 980-981 16467870 denotes 3
T26868 1233-1234 16520391 denotes 4
T53446 1235-1236 15662016 denotes 5
T76890 1334-1335 16489117 denotes 6
T96105 1411-1412 15634907 denotes 7
T85669 1468-1469 10549629 denotes 8
T87774 1524-1525 11390432 denotes 9
T61485 2277-2279 14676299 denotes 10
T25969 2447-2449 15753318 denotes 11
T96747 2450-2452 14597769 denotes 12
T99026 2512-2514 17185041 denotes 13
T47692 2515-2517 17154262 denotes 14
T1813 2713-2715 15809351 denotes 15
T36804 2785-2787 11045997 denotes 16
T37257 2898-2900 15809351 denotes 15
T43404 2901-2903 16973386 denotes 17

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T1011 13-22 JJ denotes Effective
T1012 23-29 JJ denotes immune
T1013 30-39 NN denotes responses
T1014 40-43 VB denotes are
T1015 44-57 VB denotes characterized
T1016 58-60 IN denotes by
T1017 61-62 NN denotes T
T1018 63-67 NN denotes cell
T1019 68-78 NN denotes activation
T1020 78-79 -COMMA- denotes ,
T1021 80-85 WDT denotes which
T1022 86-93 VB denotes directs
T1023 94-102 JJ denotes adaptive
T1024 103-106 CC denotes and
T1025 107-113 JJ denotes innate
T1026 114-120 JJ denotes immune
T1027 121-130 NN denotes responses
T1028 131-133 TO denotes to
T1029 134-138 VB denotes kill
T1030 139-148 NN denotes pathogens
T1031 149-160 RB denotes efficiently
T1032 162-171 JJ denotes Dependent
T1033 172-174 IN denotes on
T1034 175-178 DT denotes the
T1035 179-187 NN denotes pathogen
T1036 187-188 -COMMA- denotes ,
T1037 189-190 NN denotes T
T1038 191-196 NN denotes cells
T1039 197-210 VB denotes differentiate
T1040 211-215 IN denotes into
T1041 216-225 JJ denotes different
T1042 226-234 NN denotes subtypes
T1043 234-235 -COMMA- denotes ,
T1044 236-240 JJ denotes such
T1045 241-243 IN denotes as
T1046 244-247 NN denotes Th1
T1047 248-250 CC denotes or
T1048 251-254 NN denotes Th2
T1049 255-260 NN denotes cells
T1050 260-261 -COMMA- denotes ,
T1051 262-267 WDT denotes which
T1052 268-271 VB denotes are
T1053 272-276 RB denotes most
T1054 277-286 JJ denotes efficient
T1055 287-289 IN denotes in
T1056 290-299 VB denotes defeating
T1057 300-309 JJ denotes microbial
T1058 310-312 CC denotes or
T1059 313-322 JJ denotes parasitic
T1060 323-331 NN denotes invaders
T1061 332-344 RB denotes respectively
T1062 346-347 DT denotes A
T1063 348-356 NN denotes hallmark
T1064 357-359 IN denotes of
T1065 360-363 NN denotes Th1
T1066 364-367 CC denotes and
T1067 368-371 NN denotes Th2
T1068 372-387 NN denotes differentiation
T1069 388-396 NN denotes pathways
T1070 397-399 VB denotes is
T1071 400-403 DT denotes the
T1072 404-417 NN denotes exclusiveness
T1073 418-420 IN denotes of
T1074 421-424 DT denotes the
T1075 425-435 JJ denotes individual
T1076 436-445 NN denotes phenotype
T1077 446-453 VB denotes leading
T1078 454-456 TO denotes to
T1079 457-463 CC denotes either
T1080 464-467 NN denotes Th1
T1081 468-470 CC denotes or
T1082 471-474 NN denotes Th2
T1083 474-475 -COMMA- denotes ,
T1084 476-479 CC denotes but
T1085 480-483 RB denotes not
T1086 484-486 TO denotes to
T1087 487-492 JJ denotes mixed
T1088 493-504 NN denotes populations
T1089 506-509 DT denotes The
T1090 510-523 NN denotes exclusiveness
T1091 524-526 IN denotes of
T1092 527-531 DT denotes this
T1093 532-541 NN denotes mechanism
T1094 542-544 VB denotes is
T1095 545-553 VB denotes provided
T1096 554-556 IN denotes by
T1097 557-558 DT denotes a
T1098 559-571 NN denotes polarization
T1099 572-579 NN denotes process
T1100 579-580 -COMMA- denotes ,
T1101 581-586 WRB denotes where
T1102 587-590 NN denotes Th2
T1103 591-606 NN denotes differentiation
T1104 607-615 VB denotes inhibits
T1105 616-619 NN denotes Th1
T1106 620-630 NN denotes commitment
T1107 631-634 CC denotes and
T1108 635-639 NN denotes vice
T1109 640-645 NN denotes versa
T1110 647-659 RB denotes Specifically
T1111 660-671 NN denotes interleukin
T1112 672-673 CD denotes 4
T1113 674-675 -LRB- denotes (
T1114 675-679 NN denotes IL-4
T1115 679-680 -RRB- denotes )
T1116 680-688 VB denotes –induced
T1117 689-694 NN denotes STAT6
T1118 695-698 CC denotes and
T1119 699-704 NN denotes GATA3
T1120 705-712 VB denotes inhibit
T1121 713-728 NN denotes differentiation
T1122 729-733 IN denotes into
T1123 734-737 NN denotes Th1
T1124 738-743 NN denotes cells
T1125 744-746 IN denotes in
T1126 747-750 DT denotes the
T1127 751-756 JJ denotes early
T1128 757-762 NN denotes phase
T1129 763-765 IN denotes of
T1130 766-776 NN denotes commitment
T1131 777-778 -LRB- denotes [
T1132 778-781 CD denotes 1,2
T1133 781-782 -RRB- denotes ]
T1134 784-789 NN denotes GATA3
T1135 790-792 VB denotes is
T1136 793-803 JJ denotes sufficient
T1137 804-806 TO denotes to
T1138 807-813 VB denotes induce
T1139 814-815 DT denotes a
T1140 816-819 NN denotes Th2
T1141 820-829 NN denotes phenotype
T1142 830-831 -LRB- denotes [
T1143 831-832 CD denotes 3
T1144 832-833 -RRB- denotes ]
T1145 834-837 CC denotes and
T1146 838-842 VB denotes acts
T1147 843-846 RB denotes not
T1148 847-851 RB denotes only
T1149 852-859 IN denotes through
T1150 860-863 DT denotes the
T1151 864-873 NN denotes induction
T1152 874-876 IN denotes of
T1153 877-881 NN denotes IL-4
T1154 881-882 -COMMA- denotes ,
T1155 883-887 NN denotes IL-5
T1156 888-891 CC denotes and
T1157 892-897 NN denotes IL-13
T1158 897-898 -COMMA- denotes ,
T1159 899-902 DT denotes the
T1160 903-906 NN denotes Th2
T1161 907-916 NN denotes cytokines
T1162 916-917 -COMMA- denotes ,
T1163 918-921 CC denotes but
T1164 922-926 RB denotes also
T1165 927-934 IN denotes through
T1166 935-938 DT denotes the
T1167 939-949 NN denotes inhibition
T1168 950-952 IN denotes of
T1169 953-956 NN denotes Th1
T1170 957-970 JJ denotes cell-specific
T1171 971-978 NN denotes factors
T1172 979-980 -LRB- denotes [
T1173 980-981 CD denotes 3
T1174 981-982 -RRB- denotes ]
T1175 984-992 RB denotes Recently
T1176 992-993 -COMMA- denotes ,
T1177 994-996 PRP denotes it
T1178 997-1000 VB denotes was
T1179 1001-1006 VB denotes shown
T1180 1007-1011 IN denotes that
T1181 1012-1017 NN denotes T-bet
T1182 1018-1026 RB denotes directly
T1183 1027-1036 VB denotes modulates
T1184 1037-1042 NN denotes GATA3
T1185 1043-1051 NN denotes function
T1186 1051-1052 -COMMA- denotes ,
T1187 1053-1063 VB denotes suggesting
T1188 1064-1068 IN denotes that
T1189 1069-1082 NN denotes transcription
T1190 1083-1090 NN denotes factors
T1191 1091-1098 VB denotes compete
T1192 1099-1101 IN denotes in
T1193 1102-1105 DT denotes the
T1194 1106-1111 JJ denotes early
T1195 1112-1127 NN denotes differentiation
T1196 1128-1133 NN denotes phase
T1197 1134-1136 IN denotes of
T1198 1137-1138 NN denotes T
T1199 1139-1144 NN denotes cells
T1200 1144-1145 -COMMA- denotes ,
T1201 1146-1157 RB denotes potentially
T1202 1158-1169 VB denotes integrating
T1203 1170-1183 JJ denotes environmental
T1204 1184-1191 NN denotes signals
T1205 1192-1194 TO denotes to
T1206 1195-1202 RB denotes finally
T1207 1203-1210 VB denotes imprint
T1208 1211-1214 DT denotes the
T1209 1215-1216 NN denotes T
T1210 1217-1221 NN denotes cell
T1211 1222-1231 NN denotes phenotype
T1212 1232-1233 -LRB- denotes [
T1213 1233-1236 CD denotes 4,5
T1214 1236-1237 -RRB- denotes ]
T1215 1239-1240 DT denotes A
T1216 1241-1256 JJ denotes GATA3-dominated
T1217 1257-1263 JJ denotes immune
T1218 1264-1272 NN denotes response
T1219 1273-1276 VB denotes has
T1220 1277-1281 VB denotes been
T1221 1282-1287 VB denotes shown
T1222 1288-1290 TO denotes to
T1223 1291-1293 VB denotes be
T1224 1294-1303 JJ denotes essential
T1225 1304-1306 IN denotes in
T1226 1307-1313 NN denotes airway
T1227 1314-1332 NN denotes hyperresonsiveness
T1228 1333-1334 -LRB- denotes [
T1229 1334-1335 CD denotes 6
T1230 1335-1336 -RRB- denotes ]
T1231 1337-1340 CC denotes and
T1232 1341-1355 JJ denotes IL-4–dominated
T1233 1356-1365 NN denotes responses
T1234 1366-1369 MD denotes can
T1235 1370-1375 VB denotes break
T1236 1376-1392 JJ denotes antigen-specific
T1237 1393-1399 JJ denotes immune
T1238 1400-1409 NN denotes tolerance
T1239 1410-1411 -LRB- denotes [
T1240 1411-1412 CD denotes 7
T1241 1412-1413 -RRB- denotes ]
T1242 1415-1429 NN denotes Overexpression
T1243 1430-1432 IN denotes of
T1244 1433-1434 DT denotes a
T1245 1435-1443 JJ denotes dominant
T1246 1444-1452 JJ denotes negative
T1247 1453-1457 NN denotes form
T1248 1458-1460 IN denotes of
T1249 1461-1466 NN denotes GATA3
T1250 1467-1468 -LRB- denotes [
T1251 1468-1469 CD denotes 8
T1252 1469-1470 -RRB- denotes ]
T1253 1471-1473 CC denotes or
T1254 1474-1483 NN denotes treatment
T1255 1484-1488 IN denotes with
T1256 1489-1507 JJ denotes antisense-mediated
T1257 1508-1513 NN denotes GATA3
T1258 1514-1522 NN denotes blockade
T1259 1523-1524 -LRB- denotes [
T1260 1524-1525 CD denotes 9
T1261 1525-1526 -RRB- denotes ]
T1262 1527-1536 VB denotes decreased
T1263 1537-1540 DT denotes the
T1264 1541-1549 NN denotes severity
T1265 1550-1552 IN denotes of
T1266 1553-1556 DT denotes the
T1267 1557-1565 JJ denotes allergic
T1268 1566-1572 NN denotes airway
T1269 1573-1593 NN denotes hyper-responsiveness
T1270 1595-1598 DT denotes The
T1271 1599-1608 NN denotes discovery
T1272 1609-1611 IN denotes of
T1273 1612-1622 JJ denotes regulatory
T1274 1623-1624 NN denotes T
T1275 1625-1626 -LRB- denotes (
T1276 1626-1630 NN denotes Treg
T1277 1630-1631 -RRB- denotes )
T1278 1632-1637 NN denotes cells
T1279 1638-1648 VB denotes highlights
T1280 1649-1656 DT denotes another
T1281 1657-1666 NN denotes phenotype
T1282 1667-1669 IN denotes of
T1283 1670-1671 NN denotes T
T1284 1672-1677 NN denotes cells
T1285 1677-1678 -COMMA- denotes ,
T1286 1679-1684 WDT denotes which
T1287 1685-1687 VB denotes is
T1288 1688-1697 JJ denotes essential
T1289 1698-1701 IN denotes for
T1290 1702-1711 NN denotes tolerance
T1291 1712-1719 IN denotes against
T1292 1720-1733 NN denotes self-antigens
T1293 1735-1744 RB denotes Naturally
T1294 1745-1754 VB denotes occurring
T1295 1754-1755 -COMMA- denotes ,
T1296 1756-1770 JJ denotes thymus-derived
T1297 1771-1775 NN denotes Treg
T1298 1776-1777 -LRB- denotes (
T1299 1777-1782 NN denotes nTreg
T1300 1782-1783 -RRB- denotes )
T1301 1784-1789 NN denotes cells
T1302 1790-1793 VB denotes are
T1303 1794-1803 VB denotes generated
T1304 1804-1806 IN denotes in
T1305 1807-1810 DT denotes the
T1306 1811-1817 NN denotes thymus
T1307 1818-1821 CC denotes and
T1308 1822-1825 VB denotes are
T1309 1826-1833 VB denotes assumed
T1310 1834-1836 TO denotes to
T1311 1837-1844 VB denotes protect
T1312 1845-1852 IN denotes against
T1313 1853-1856 DT denotes the
T1314 1857-1865 NN denotes activity
T1315 1866-1868 IN denotes of
T1316 1869-1881 JJ denotes autoreactive
T1317 1882-1883 NN denotes T
T1318 1884-1889 NN denotes cells
T1319 1890-1892 IN denotes in
T1320 1893-1896 DT denotes the
T1321 1897-1906 NN denotes periphery
T1322 1908-1913 DT denotes These
T1323 1914-1919 NN denotes cells
T1324 1920-1927 VB denotes express
T1325 1928-1931 DT denotes the
T1326 1932-1940 NN denotes forkhead
T1327 1941-1954 NN denotes transcription
T1328 1955-1961 NN denotes factor
T1329 1962-1967 NN denotes FOXP3
T1330 1968-1971 CC denotes and
T1331 1972-1986 RB denotes constitutively
T1332 1987-1994 VB denotes express
T1333 1995-1999 NN denotes CD25
T1334 2000-2002 IN denotes on
T1335 2003-2008 PRP-DOLLAR- denotes their
T1336 2009-2016 NN denotes surface
T1337 2016-2017 -COMMA- denotes ,
T1338 2018-2021 CC denotes but
T1339 2022-2026 PRP denotes they
T1340 2027-2031 VB denotes lack
T1341 2032-2042 NN denotes expression
T1342 2043-2045 IN denotes of
T1343 2046-2049 NN denotes Th1
T1344 2050-2052 CC denotes or
T1345 2053-2056 NN denotes Th2
T1346 2057-2066 NN denotes cytokines
T1347 2068-2080 RB denotes Particularly
T1348 2081-2092 JJ denotes interesting
T1349 2093-2096 VB denotes are
T1350 2097-2102 DT denotes those
T1351 2103-2107 NN denotes Treg
T1352 2108-2113 NN denotes cells
T1353 2114-2118 WDT denotes that
T1354 2119-2122 VB denotes are
T1355 2123-2132 VB denotes generated
T1356 2133-2135 IN denotes in
T1357 2136-2139 DT denotes the
T1358 2140-2149 NN denotes periphery
T1359 2150-2153 CC denotes and
T1360 2154-2158 RB denotes thus
T1361 2159-2162 VB denotes are
T1362 2163-2172 JJ denotes potential
T1363 2173-2180 NN denotes targets
T1364 2181-2184 IN denotes for
T1365 2185-2196 JJ denotes therapeutic
T1366 2197-2210 NN denotes interventions
T1367 2212-2217 DT denotes These
T1368 2218-2225 VB denotes induced
T1369 2226-2230 NN denotes Treg
T1370 2231-2232 -LRB- denotes (
T1371 2232-2237 NN denotes iTreg
T1372 2237-2238 -RRB- denotes )
T1373 2239-2244 NN denotes cells
T1374 2245-2249 VB denotes were
T1375 2250-2258 VB denotes reported
T1376 2259-2261 TO denotes to
T1377 2262-2269 VB denotes express
T1378 2270-2275 NN denotes FOXP3
T1379 2276-2277 -LRB- denotes [
T1380 2277-2279 CD denotes 10
T1381 2279-2280 -RRB- denotes ]
T1382 2282-2285 DT denotes The
T1383 2286-2291 JJ denotes exact
T1384 2292-2302 NN denotes mechanisms
T1385 2303-2305 IN denotes of
T1386 2306-2311 NN denotes iTreg
T1387 2312-2322 NN denotes generation
T1388 2323-2326 VB denotes are
T1389 2327-2334 JJ denotes unclear
T1390 2334-2335 -COMMA- denotes ,
T1391 2336-2339 CC denotes but
T1392 2340-2341 NN denotes T
T1393 2342-2346 NN denotes cell
T1394 2347-2355 NN denotes receptor
T1395 2356-2357 -LRB- denotes (
T1396 2357-2360 NN denotes TCR
T1397 2360-2361 -RRB- denotes )
T1398 2362-2372 NN denotes triggering
T1399 2373-2376 VB denotes has
T1400 2377-2381 VB denotes been
T1401 2382-2387 VB denotes shown
T1402 2388-2390 TO denotes to
T1403 2391-2397 VB denotes induce
T1404 2398-2403 NN denotes FOXP3
T1405 2404-2414 NN denotes expression
T1406 2415-2418 CC denotes and
T1407 2419-2430 JJ denotes suppressive
T1408 2431-2436 NN denotes cells
T1409 2437-2439 IN denotes in
T1410 2440-2445 JJ denotes human
T1411 2446-2447 -LRB- denotes [
T1412 2447-2452 CD denotes 11,12
T1413 2452-2453 -RRB- denotes ]
T1414 2453-2454 -COMMA- denotes ,
T1415 2455-2462 RB denotes however
T1416 2463-2466 DT denotes the
T1417 2467-2476 NN denotes phenotype
T1418 2477-2484 VB denotes appears
T1419 2485-2487 TO denotes to
T1420 2488-2490 VB denotes be
T1421 2491-2493 IN denotes of
T1422 2494-2503 JJ denotes transient
T1423 2504-2510 NN denotes nature
T1424 2511-2512 -LRB- denotes [
T1425 2512-2517 CD denotes 13,14
T1426 2517-2518 -RRB- denotes ]
T1427 2520-2525 NN denotes TGF-β
T1428 2526-2529 VB denotes has
T1429 2530-2534 VB denotes been
T1430 2535-2547 VB denotes demonstrated
T1431 2548-2550 TO denotes to
T1432 2551-2553 VB denotes be
T1433 2554-2563 JJ denotes important
T1434 2564-2567 IN denotes for
T1435 2568-2571 DT denotes the
T1436 2572-2582 JJ denotes persistent
T1437 2583-2592 NN denotes induction
T1438 2593-2595 IN denotes of
T1439 2596-2601 DT denotes these
T1440 2602-2607 NN denotes cells
T1441 2608-2610 FW denotes in
T1442 2611-2616 FW denotes vitro
T1443 2617-2620 CC denotes and
T1444 2621-2623 FW denotes in
T1445 2624-2628 FW denotes vivo
T1446 2628-2629 -COMMA- denotes ,
T1447 2630-2635 IN denotes since
T1448 2636-2643 NN denotes animals
T1449 2644-2651 VB denotes lacking
T1450 2652-2655 DT denotes the
T1451 2656-2664 NN denotes TGF-βRII
T1452 2665-2667 IN denotes on
T1453 2668-2669 NN denotes T
T1454 2670-2675 NN denotes cells
T1455 2676-2680 VB denotes have
T1456 2681-2686 JJ denotes fewer
T1457 2687-2699 RB denotes peripherally
T1458 2700-2705 NN denotes iTreg
T1459 2706-2711 NN denotes cells
T1460 2712-2713 -LRB- denotes [
T1461 2713-2715 CD denotes 15
T1462 2715-2716 -RRB- denotes ]
T1463 2717-2720 CC denotes and
T1464 2721-2727 VB denotes suffer
T1465 2728-2732 IN denotes from
T1466 2733-2734 DT denotes a
T1467 2735-2736 NN denotes T
T1468 2737-2751 JJ denotes cell–dependent
T1469 2752-2762 JJ denotes multiorgan
T1470 2763-2775 JJ denotes inflammatory
T1471 2776-2783 NN denotes disease
T1472 2784-2785 -LRB- denotes [
T1473 2785-2787 CD denotes 16
T1474 2787-2788 -RRB- denotes ]
T1475 2790-2798 IN denotes Although
T1476 2799-2802 DT denotes the
T1477 2803-2809 NN denotes effect
T1478 2810-2812 IN denotes of
T1479 2813-2818 NN denotes TGF-β
T1480 2819-2821 IN denotes on
T1481 2822-2829 JJ denotes natural
T1482 2830-2833 CC denotes and
T1483 2834-2843 JJ denotes inducible
T1484 2844-2848 NN denotes Treg
T1485 2849-2853 NN denotes cell
T1486 2854-2863 NN denotes induction
T1487 2864-2867 VB denotes has
T1488 2868-2872 VB denotes been
T1489 2873-2885 VB denotes demonstrated
T1490 2886-2896 RB denotes repeatedly
T1491 2897-2898 -LRB- denotes [
T1492 2898-2903 CD denotes 15,17
T1493 2903-2904 -RRB- denotes ]
T1494 2904-2905 -COMMA- denotes ,
T1495 2906-2909 PRP-DOLLAR- denotes its
T1496 2910-2919 JJ denotes molecular
T1497 2920-2930 NN denotes mechanisms
T1498 2931-2937 VB denotes remain
T1499 2938-2940 TO denotes to
T1500 2941-2943 VB denotes be
T1501 2944-2954 VB denotes identified
T1502 2956-2959 DT denotes The
T1503 2960-2967 JJ denotes current
T1504 2968-2973 NN denotes study
T1505 2974-2982 VB denotes provides
T1506 2983-2991 NN denotes evidence
T1507 2992-2996 IN denotes that
T1508 2997-3002 NN denotes GATA3
T1509 3003-3006 CC denotes and
T1510 3007-3012 NN denotes FOXP3
T1511 3013-3017 VB denotes play
T1512 3018-3019 DT denotes a
T1513 3020-3031 JJ denotes competitive
T1514 3032-3036 NN denotes role
T1515 3037-3039 IN denotes in
T1516 3040-3045 NN denotes iTreg
T1517 3046-3050 NN denotes cell
T1518 3051-3061 NN denotes commitment
T1519 3062-3064 IN denotes as
T1520 3065-3070 NN denotes T-bet
T1521 3071-3074 CC denotes and
T1522 3075-3080 NN denotes GATA3
T1523 3081-3084 IN denotes for
T1524 3085-3088 NN denotes Th1
T1525 3089-3092 CC denotes and
T1526 3093-3096 NN denotes Th2
T1527 3097-3112 NN denotes differentiation
T1528 3112-3113 -COMMA- denotes ,
T1529 3114-3126 RB denotes respectively
T1530 3128-3130 PRP denotes We
T1531 3131-3135 VB denotes show
T1532 3136-3140 IN denotes that
T1533 3141-3146 NN denotes GATA3
T1534 3147-3155 VB denotes inhibits
T1535 3156-3161 NN denotes FOXP3
T1536 3162-3171 NN denotes induction
T1537 3172-3175 CC denotes and
T1538 3176-3180 IN denotes that
T1539 3181-3185 NN denotes IL-4
T1540 3186-3192 VB denotes limits
T1541 3193-3198 NN denotes FOXP3
T1542 3199-3209 NN denotes expression
T1543 3210-3212 IN denotes in
T1544 3213-3214 DT denotes a
T1545 3215-3229 JJ denotes GATA3-mediated
T1546 3230-3233 NN denotes way
T1547 3233-3234 -COMMA- denotes ,
T1548 3235-3239 CC denotes both
T1549 3240-3242 FW denotes in
T1550 3243-3248 FW denotes vitro
T1551 3249-3252 CC denotes and
T1552 3253-3255 FW denotes in
T1553 3256-3260 FW denotes vivo
T1554 3262-3264 PRP denotes We
T1555 3265-3269 RB denotes also
T1556 3270-3274 VB denotes show
T1557 3275-3279 IN denotes that
T1558 3280-3285 NN denotes GATA3
T1559 3286-3294 RB denotes directly
T1560 3295-3300 VB denotes binds
T1561 3301-3303 TO denotes to
T1562 3304-3307 DT denotes the
T1563 3308-3313 NN denotes FOXP3
T1564 3314-3322 NN denotes promoter
T1565 3323-3326 CC denotes and
T1566 3327-3334 RB denotes thereby
T1567 3335-3343 VB denotes prevents
T1568 3344-3347 DT denotes the
T1569 3348-3357 NN denotes induction
T1570 3358-3360 IN denotes of
T1571 3361-3365 DT denotes this
T1572 3366-3370 NN denotes gene
T1573 3370-3371 -COMMA- denotes ,
T1574 3372-3385 VB denotes demonstrating
T1575 3386-3390 IN denotes that
T1576 3391-3394 NN denotes Th2
T1577 3395-3410 NN denotes differentiation
T1578 3411-3420 VB denotes overrules
T1579 3421-3426 NN denotes iTreg
T1580 3427-3436 NN denotes induction
R770 T1013 T1011 arg1Of responses,Effective
R771 T1013 T1012 arg1Of responses,immune
R772 T1013 T1014 arg1Of responses,are
R773 T1013 T1015 arg2Of responses,characterized
R774 T1015 T1014 arg2Of characterized,are
R775 T1019 T1015 arg1Of activation,characterized
R776 T1019 T1016 arg2Of activation,by
R777 T1019 T1017 arg1Of activation,T
R778 T1019 T1018 arg1Of activation,cell
R779 T1019 T1020 arg1Of activation,","
R780 T1019 T1021 arg1Of activation,which
R781 T1019 T1022 arg1Of activation,directs
R782 T1022 T1028 modOf directs,to
R783 T1023 T1024 arg1Of adaptive,and
R784 T1025 T1024 arg2Of innate,and
R785 T1027 T1022 arg2Of responses,directs
R786 T1027 T1023 arg1Of responses,adaptive
R787 T1027 T1025 arg1Of responses,innate
R788 T1027 T1026 arg1Of responses,immune
R789 T1029 T1028 arg1Of kill,to
R790 T1029 T1031 arg1Of kill,efficiently
R791 T1030 T1029 arg2Of pathogens,kill
R792 T1032 T1033 arg1Of Dependent,on
R793 T1035 T1033 arg2Of pathogen,on
R794 T1035 T1034 arg1Of pathogen,the
R795 T1038 T1032 arg1Of cells,Dependent
R796 T1038 T1036 arg1Of cells,","
R797 T1038 T1037 arg1Of cells,T
R798 T1038 T1039 arg1Of cells,differentiate
R799 T1039 T1040 arg1Of differentiate,into
R800 T1042 T1040 arg2Of subtypes,into
R801 T1042 T1041 arg1Of subtypes,different
R802 T1042 T1043 arg1Of subtypes,","
R803 T1042 T1045 arg1Of subtypes,as
R804 T1045 T1044 arg1Of as,such
R805 T1046 T1047 arg1Of Th1,or
R806 T1048 T1047 arg2Of Th2,or
R807 T1049 T1045 arg2Of cells,as
R808 T1049 T1046 arg1Of cells,Th1
R809 T1049 T1048 arg1Of cells,Th2
R810 T1049 T1050 arg1Of cells,","
R811 T1049 T1051 arg1Of cells,which
R812 T1049 T1052 arg1Of cells,are
R813 T1049 T1054 arg1Of cells,efficient
R814 T1049 T1056 arg1Of cells,defeating
R815 T1052 T1055 arg1Of are,in
R816 T1054 T1052 arg2Of efficient,are
R817 T1054 T1053 arg1Of efficient,most
R818 T1056 T1055 arg2Of defeating,in
R819 T1056 T1061 arg1Of defeating,respectively
R820 T1057 T1058 arg1Of microbial,or
R821 T1059 T1058 arg2Of parasitic,or
R822 T1060 T1056 arg2Of invaders,defeating
R823 T1060 T1057 arg1Of invaders,microbial
R824 T1060 T1059 arg1Of invaders,parasitic
R825 T1063 T1062 arg1Of hallmark,A
R826 T1063 T1064 arg1Of hallmark,of
R827 T1063 T1070 arg1Of hallmark,is
R828 T1065 T1066 arg1Of Th1,and
R829 T1067 T1066 arg2Of Th2,and
R830 T1069 T1064 arg2Of pathways,of
R831 T1069 T1065 arg1Of pathways,Th1
R832 T1069 T1067 arg1Of pathways,Th2
R833 T1069 T1068 arg1Of pathways,differentiation
R834 T1072 T1070 arg2Of exclusiveness,is
R835 T1072 T1071 arg1Of exclusiveness,the
R836 T1072 T1073 arg1Of exclusiveness,of
R837 T1076 T1073 arg2Of phenotype,of
R838 T1076 T1074 arg1Of phenotype,the
R839 T1076 T1075 arg1Of phenotype,individual
R840 T1076 T1077 arg1Of phenotype,leading
R841 T1077 T1078 arg1Of leading,to
R842 T1077 T1086 arg1Of leading,to
R843 T1078 T1084 arg1Of to,but
R844 T1080 T1081 arg1Of Th1,or
R845 T1081 T1078 arg2Of or,to
R846 T1081 T1079 arg1Of or,either
R847 T1082 T1081 arg2Of Th2,or
R848 T1084 T1083 arg1Of but,","
R849 T1086 T1084 arg2Of to,but
R850 T1086 T1085 arg1Of to,not
R851 T1088 T1086 arg2Of populations,to
R852 T1088 T1087 arg1Of populations,mixed
R853 T1090 T1089 arg1Of exclusiveness,The
R854 T1090 T1091 arg1Of exclusiveness,of
R855 T1090 T1094 arg1Of exclusiveness,is
R856 T1090 T1095 arg2Of exclusiveness,provided
R857 T1093 T1091 arg2Of mechanism,of
R858 T1093 T1092 arg1Of mechanism,this
R859 T1095 T1094 arg2Of provided,is
R860 T1099 T1095 arg1Of process,provided
R861 T1099 T1096 arg2Of process,by
R862 T1099 T1097 arg1Of process,a
R863 T1099 T1098 arg1Of process,polarization
R864 T1099 T1100 arg1Of process,","
R865 T1099 T1101 arg1Of process,where
R866 T1103 T1102 arg1Of differentiation,Th2
R867 T1103 T1104 arg1Of differentiation,inhibits
R868 T1104 T1101 arg2Of inhibits,where
R869 T1106 T1105 arg1Of commitment,Th1
R870 T1106 T1107 arg1Of commitment,and
R871 T1107 T1104 arg2Of and,inhibits
R872 T1109 T1107 arg2Of versa,and
R873 T1109 T1108 arg1Of versa,vice
R874 T1111 T1112 arg1Of interleukin,4
R875 T1111 T1113 arg1Of interleukin,(
R876 T1111 T1116 arg1Of interleukin,–induced
R877 T1114 T1113 arg2Of IL-4,(
R878 T1115 T1113 arg3Of ),(
R879 T1116 T1110 arg1Of –induced,Specifically
R880 T1117 T1118 arg1Of STAT6,and
R881 T1118 T1120 arg1Of and,inhibit
R882 T1119 T1118 arg2Of GATA3,and
R883 T1120 T1116 arg2Of inhibit,–induced
R884 T1120 T1122 arg1Of inhibit,into
R885 T1120 T1125 arg1Of inhibit,in
R886 T1121 T1120 arg2Of differentiation,inhibit
R887 T1124 T1122 arg2Of cells,into
R888 T1124 T1123 arg1Of cells,Th1
R889 T1128 T1125 arg2Of phase,in
R890 T1128 T1126 arg1Of phase,the
R891 T1128 T1127 arg1Of phase,early
R892 T1128 T1129 arg1Of phase,of
R893 T1130 T1129 arg2Of commitment,of
R894 T1130 T1131 arg1Of commitment,[
R895 T1132 T1131 arg2Of "1,2",[
R896 T1133 T1131 arg3Of ],[
R897 T1134 T1135 arg1Of GATA3,is
R898 T1134 T1136 arg1Of GATA3,sufficient
R899 T1134 T1138 arg1Of GATA3,induce
R900 T1134 T1146 arg1Of GATA3,acts
R901 T1135 T1145 arg1Of is,and
R902 T1136 T1135 arg2Of sufficient,is
R903 T1138 T1136 arg2Of induce,sufficient
R904 T1138 T1137 arg1Of induce,to
R905 T1138 T1142 arg1Of induce,[
R906 T1141 T1138 arg2Of phenotype,induce
R907 T1141 T1139 arg1Of phenotype,a
R908 T1141 T1140 arg1Of phenotype,Th2
R909 T1143 T1142 arg2Of 3,[
R910 T1144 T1142 arg3Of ],[
R911 T1146 T1145 arg2Of acts,and
R912 T1146 T1149 arg1Of acts,through
R913 T1146 T1165 arg1Of acts,through
R914 T1148 T1147 arg1Of only,not
R915 T1149 T1163 arg1Of through,but
R916 T1151 T1149 arg2Of induction,through
R917 T1151 T1150 arg1Of induction,the
R918 T1151 T1152 arg1Of induction,of
R919 T1153 T1154 arg1Of IL-4,","
R920 T1154 T1156 arg1Of ",",and
R921 T1155 T1154 arg2Of IL-5,","
R922 T1156 T1152 arg2Of and,of
R923 T1156 T1158 arg1Of and,","
R924 T1157 T1156 arg2Of IL-13,and
R925 T1161 T1158 arg2Of cytokines,","
R926 T1161 T1159 arg1Of cytokines,the
R927 T1161 T1160 arg1Of cytokines,Th2
R928 T1163 T1148 arg1Of but,only
R929 T1163 T1162 arg1Of but,","
R930 T1163 T1164 arg1Of but,also
R931 T1165 T1163 arg2Of through,but
R932 T1167 T1165 arg2Of inhibition,through
R933 T1167 T1166 arg1Of inhibition,the
R934 T1167 T1168 arg1Of inhibition,of
R935 T1171 T1168 arg2Of factors,of
R936 T1171 T1169 arg1Of factors,Th1
R937 T1171 T1170 arg1Of factors,cell-specific
R938 T1171 T1172 arg1Of factors,[
R939 T1173 T1172 arg2Of 3,[
R940 T1174 T1172 arg3Of ],[
R941 T1177 T1178 arg1Of it,was
R942 T1177 T1179 arg2Of it,shown
R943 T1179 T1175 arg1Of shown,Recently
R944 T1179 T1176 arg1Of shown,","
R945 T1179 T1178 arg2Of shown,was
R946 T1181 T1183 arg1Of T-bet,modulates
R947 T1183 T1179 arg3Of modulates,shown
R948 T1183 T1180 arg1Of modulates,that
R949 T1183 T1182 arg1Of modulates,directly
R950 T1183 T1186 arg1Of modulates,","
R951 T1183 T1187 modOf modulates,suggesting
R952 T1185 T1183 arg2Of function,modulates
R953 T1185 T1184 arg1Of function,GATA3
R954 T1190 T1189 arg1Of factors,transcription
R955 T1190 T1191 arg1Of factors,compete
R956 T1190 T1202 arg1Of factors,integrating
R957 T1191 T1187 arg2Of compete,suggesting
R958 T1191 T1188 arg1Of compete,that
R959 T1191 T1192 arg1Of compete,in
R960 T1191 T1200 arg1Of compete,","
R961 T1191 T1202 modOf compete,integrating
R962 T1196 T1192 arg2Of phase,in
R963 T1196 T1193 arg1Of phase,the
R964 T1196 T1194 arg1Of phase,early
R965 T1196 T1195 arg1Of phase,differentiation
R966 T1196 T1197 arg1Of phase,of
R967 T1199 T1197 arg2Of cells,of
R968 T1199 T1198 arg1Of cells,T
R969 T1202 T1201 arg1Of integrating,potentially
R970 T1202 T1205 modOf integrating,to
R971 T1204 T1202 arg2Of signals,integrating
R972 T1204 T1203 arg1Of signals,environmental
R973 T1207 T1205 arg1Of imprint,to
R974 T1207 T1206 arg1Of imprint,finally
R975 T1207 T1212 arg1Of imprint,[
R976 T1211 T1207 arg2Of phenotype,imprint
R977 T1211 T1208 arg1Of phenotype,the
R978 T1211 T1209 arg1Of phenotype,T
R979 T1211 T1210 arg1Of phenotype,cell
R980 T1213 T1212 arg2Of "4,5",[
R981 T1214 T1212 arg3Of ],[
R982 T1218 T1215 arg1Of response,A
R983 T1218 T1216 arg1Of response,GATA3-dominated
R984 T1218 T1217 arg1Of response,immune
R985 T1218 T1219 arg1Of response,has
R986 T1218 T1220 arg1Of response,been
R987 T1218 T1221 arg2Of response,shown
R988 T1218 T1223 arg1Of response,be
R989 T1218 T1224 arg1Of response,essential
R990 T1221 T1219 arg2Of shown,has
R991 T1221 T1220 arg2Of shown,been
R992 T1221 T1231 arg1Of shown,and
R993 T1223 T1221 arg3Of be,shown
R994 T1223 T1222 arg1Of be,to
R995 T1223 T1228 arg1Of be,[
R996 T1224 T1223 arg2Of essential,be
R997 T1224 T1225 arg1Of essential,in
R998 T1227 T1225 arg2Of hyperresonsiveness,in
R999 T1227 T1226 arg1Of hyperresonsiveness,airway
R1000 T1229 T1228 arg2Of 6,[
R1001 T1230 T1228 arg3Of ],[
R1002 T1233 T1232 arg1Of responses,IL-4–dominated
R1003 T1233 T1234 arg1Of responses,can
R1004 T1233 T1235 arg1Of responses,break
R1005 T1235 T1231 arg2Of break,and
R1006 T1235 T1234 arg2Of break,can
R1007 T1238 T1235 arg2Of tolerance,break
R1008 T1238 T1236 arg1Of tolerance,antigen-specific
R1009 T1238 T1237 arg1Of tolerance,immune
R1010 T1238 T1239 arg1Of tolerance,[
R1011 T1240 T1239 arg2Of 7,[
R1012 T1241 T1239 arg3Of ],[
R1013 T1242 T1243 arg1Of Overexpression,of
R1014 T1242 T1262 arg1Of Overexpression,decreased
R1015 T1247 T1243 arg2Of form,of
R1016 T1247 T1244 arg1Of form,a
R1017 T1247 T1245 arg1Of form,dominant
R1018 T1247 T1246 arg1Of form,negative
R1019 T1247 T1248 arg1Of form,of
R1020 T1249 T1250 arg1Of GATA3,[
R1021 T1249 T1253 arg1Of GATA3,or
R1022 T1251 T1250 arg2Of 8,[
R1023 T1252 T1250 arg3Of ],[
R1024 T1253 T1248 arg2Of or,of
R1025 T1253 T1255 arg1Of or,with
R1026 T1254 T1253 arg2Of treatment,or
R1027 T1258 T1255 arg2Of blockade,with
R1028 T1258 T1256 arg1Of blockade,antisense-mediated
R1029 T1258 T1257 arg1Of blockade,GATA3
R1030 T1258 T1259 arg1Of blockade,[
R1031 T1260 T1259 arg2Of 9,[
R1032 T1261 T1259 arg3Of ],[
R1033 T1264 T1262 arg2Of severity,decreased
R1034 T1264 T1263 arg1Of severity,the
R1035 T1264 T1265 arg1Of severity,of
R1036 T1269 T1265 arg2Of hyper-responsiveness,of
R1037 T1269 T1266 arg1Of hyper-responsiveness,the
R1038 T1269 T1267 arg1Of hyper-responsiveness,allergic
R1039 T1269 T1268 arg1Of hyper-responsiveness,airway
R1040 T1271 T1270 arg1Of discovery,The
R1041 T1271 T1272 arg1Of discovery,of
R1042 T1271 T1279 arg1Of discovery,highlights
R1043 T1276 T1275 arg2Of Treg,(
R1044 T1277 T1275 arg3Of ),(
R1045 T1278 T1272 arg2Of cells,of
R1046 T1278 T1273 arg1Of cells,regulatory
R1047 T1278 T1274 arg1Of cells,T
R1048 T1278 T1275 arg1Of cells,(
R1049 T1281 T1279 arg2Of phenotype,highlights
R1050 T1281 T1280 arg1Of phenotype,another
R1051 T1281 T1282 arg1Of phenotype,of
R1052 T1281 T1285 arg1Of phenotype,","
R1053 T1281 T1286 arg1Of phenotype,which
R1054 T1281 T1287 arg1Of phenotype,is
R1055 T1281 T1288 arg1Of phenotype,essential
R1056 T1284 T1282 arg2Of cells,of
R1057 T1284 T1283 arg1Of cells,T
R1058 T1288 T1287 arg2Of essential,is
R1059 T1288 T1289 arg1Of essential,for
R1060 T1290 T1289 arg2Of tolerance,for
R1061 T1290 T1291 arg1Of tolerance,against
R1062 T1292 T1291 arg2Of self-antigens,against
R1063 T1294 T1293 arg1Of occurring,Naturally
R1064 T1294 T1295 arg1Of occurring,","
R1065 T1296 T1295 arg2Of thymus-derived,","
R1066 T1299 T1298 arg2Of nTreg,(
R1067 T1300 T1298 arg3Of ),(
R1068 T1301 T1294 arg1Of cells,occurring
R1069 T1301 T1296 arg1Of cells,thymus-derived
R1070 T1301 T1297 arg1Of cells,Treg
R1071 T1301 T1298 arg1Of cells,(
R1072 T1301 T1302 arg1Of cells,are
R1073 T1301 T1303 arg2Of cells,generated
R1074 T1301 T1308 arg1Of cells,are
R1075 T1301 T1309 arg2Of cells,assumed
R1076 T1301 T1311 arg1Of cells,protect
R1077 T1303 T1302 arg2Of generated,are
R1078 T1303 T1304 arg1Of generated,in
R1079 T1303 T1307 arg1Of generated,and
R1080 T1306 T1304 arg2Of thymus,in
R1081 T1306 T1305 arg1Of thymus,the
R1082 T1309 T1307 arg2Of assumed,and
R1083 T1309 T1308 arg2Of assumed,are
R1084 T1311 T1309 arg3Of protect,assumed
R1085 T1311 T1310 arg1Of protect,to
R1086 T1311 T1312 arg1Of protect,against
R1087 T1314 T1312 arg2Of activity,against
R1088 T1314 T1313 arg1Of activity,the
R1089 T1314 T1315 arg1Of activity,of
R1090 T1314 T1319 arg1Of activity,in
R1091 T1318 T1315 arg2Of cells,of
R1092 T1318 T1316 arg1Of cells,autoreactive
R1093 T1318 T1317 arg1Of cells,T
R1094 T1321 T1319 arg2Of periphery,in
R1095 T1321 T1320 arg1Of periphery,the
R1096 T1323 T1322 arg1Of cells,These
R1097 T1323 T1324 arg1Of cells,express
R1098 T1323 T1332 arg1Of cells,express
R1099 T1324 T1330 arg1Of express,and
R1100 T1329 T1324 arg2Of FOXP3,express
R1101 T1329 T1325 arg1Of FOXP3,the
R1102 T1329 T1326 arg1Of FOXP3,forkhead
R1103 T1329 T1327 arg1Of FOXP3,transcription
R1104 T1329 T1328 arg1Of FOXP3,factor
R1105 T1330 T1338 arg1Of and,but
R1106 T1332 T1330 arg2Of express,and
R1107 T1332 T1331 arg1Of express,constitutively
R1108 T1332 T1334 arg1Of express,on
R1109 T1333 T1332 arg2Of CD25,express
R1110 T1336 T1334 arg2Of surface,on
R1111 T1336 T1335 arg1Of surface,their
R1112 T1338 T1337 arg1Of but,","
R1113 T1339 T1340 arg1Of they,lack
R1114 T1340 T1338 arg2Of lack,but
R1115 T1341 T1340 arg2Of expression,lack
R1116 T1341 T1342 arg1Of expression,of
R1117 T1343 T1344 arg1Of Th1,or
R1118 T1345 T1344 arg2Of Th2,or
R1119 T1346 T1342 arg2Of cytokines,of
R1120 T1346 T1343 arg1Of cytokines,Th1
R1121 T1346 T1345 arg1Of cytokines,Th2
R1122 T1348 T1347 arg1Of interesting,Particularly
R1123 T1348 T1349 arg2Of interesting,are
R1124 T1352 T1348 arg1Of cells,interesting
R1125 T1352 T1349 arg1Of cells,are
R1126 T1352 T1350 arg1Of cells,those
R1127 T1352 T1351 arg1Of cells,Treg
R1128 T1352 T1353 arg1Of cells,that
R1129 T1352 T1354 arg1Of cells,are
R1130 T1352 T1355 arg2Of cells,generated
R1131 T1352 T1361 arg1Of cells,are
R1132 T1355 T1354 arg2Of generated,are
R1133 T1355 T1356 arg1Of generated,in
R1134 T1355 T1359 arg1Of generated,and
R1135 T1358 T1356 arg2Of periphery,in
R1136 T1358 T1357 arg1Of periphery,the
R1137 T1361 T1359 arg2Of are,and
R1138 T1361 T1360 arg1Of are,thus
R1139 T1363 T1361 arg2Of targets,are
R1140 T1363 T1362 arg1Of targets,potential
R1141 T1363 T1364 arg1Of targets,for
R1142 T1366 T1364 arg2Of interventions,for
R1143 T1366 T1365 arg1Of interventions,therapeutic
R1144 T1371 T1370 arg2Of iTreg,(
R1145 T1372 T1370 arg3Of ),(
R1146 T1373 T1367 arg1Of cells,These
R1147 T1373 T1368 arg2Of cells,induced
R1148 T1373 T1369 arg1Of cells,Treg
R1149 T1373 T1370 arg1Of cells,(
R1150 T1373 T1374 arg1Of cells,were
R1151 T1373 T1375 arg2Of cells,reported
R1152 T1373 T1377 arg1Of cells,express
R1153 T1375 T1374 arg2Of reported,were
R1154 T1377 T1375 arg3Of express,reported
R1155 T1377 T1376 arg1Of express,to
R1156 T1377 T1379 arg1Of express,[
R1157 T1378 T1377 arg2Of FOXP3,express
R1158 T1380 T1379 arg2Of 10,[
R1159 T1381 T1379 arg3Of ],[
R1160 T1384 T1382 arg1Of mechanisms,The
R1161 T1384 T1383 arg1Of mechanisms,exact
R1162 T1384 T1385 arg1Of mechanisms,of
R1163 T1384 T1388 arg1Of mechanisms,are
R1164 T1384 T1389 arg1Of mechanisms,unclear
R1165 T1387 T1385 arg2Of generation,of
R1166 T1387 T1386 arg1Of generation,iTreg
R1167 T1388 T1391 arg1Of are,but
R1168 T1389 T1388 arg2Of unclear,are
R1169 T1391 T1390 arg1Of but,","
R1170 T1396 T1395 arg2Of TCR,(
R1171 T1397 T1395 arg3Of ),(
R1172 T1398 T1392 arg1Of triggering,T
R1173 T1398 T1393 arg1Of triggering,cell
R1174 T1398 T1394 arg1Of triggering,receptor
R1175 T1398 T1395 arg1Of triggering,(
R1176 T1398 T1399 arg1Of triggering,has
R1177 T1398 T1400 arg1Of triggering,been
R1178 T1398 T1401 arg2Of triggering,shown
R1179 T1398 T1403 arg1Of triggering,induce
R1180 T1401 T1399 arg2Of shown,has
R1181 T1401 T1400 arg2Of shown,been
R1182 T1401 T1414 arg1Of shown,","
R1183 T1403 T1401 arg3Of induce,shown
R1184 T1403 T1402 arg1Of induce,to
R1185 T1405 T1404 arg1Of expression,FOXP3
R1186 T1405 T1406 arg1Of expression,and
R1187 T1406 T1403 arg2Of and,induce
R1188 T1406 T1409 arg1Of and,in
R1189 T1408 T1406 arg2Of cells,and
R1190 T1408 T1407 arg1Of cells,suppressive
R1191 T1410 T1409 arg2Of human,in
R1192 T1410 T1411 arg1Of human,[
R1193 T1412 T1411 arg2Of "11,12",[
R1194 T1413 T1411 arg3Of ],[
R1195 T1414 T1391 arg2Of ",",but
R1196 T1417 T1416 arg1Of phenotype,the
R1197 T1417 T1418 arg1Of phenotype,appears
R1198 T1417 T1420 arg1Of phenotype,be
R1199 T1417 T1421 arg1Of phenotype,of
R1200 T1418 T1414 arg2Of appears,","
R1201 T1418 T1415 arg1Of appears,however
R1202 T1420 T1418 arg2Of be,appears
R1203 T1420 T1419 arg1Of be,to
R1204 T1421 T1420 arg2Of of,be
R1205 T1423 T1421 arg2Of nature,of
R1206 T1423 T1422 arg1Of nature,transient
R1207 T1423 T1424 arg1Of nature,[
R1208 T1425 T1424 arg2Of "13,14",[
R1209 T1426 T1424 arg3Of ],[
R1210 T1427 T1428 arg1Of TGF-β,has
R1211 T1427 T1429 arg1Of TGF-β,been
R1212 T1427 T1430 arg2Of TGF-β,demonstrated
R1213 T1427 T1432 arg1Of TGF-β,be
R1214 T1427 T1433 arg1Of TGF-β,important
R1215 T1430 T1428 arg2Of demonstrated,has
R1216 T1430 T1429 arg2Of demonstrated,been
R1217 T1432 T1430 arg3Of be,demonstrated
R1218 T1432 T1431 arg1Of be,to
R1219 T1432 T1442 arg1Of be,vitro
R1220 T1432 T1445 arg1Of be,vivo
R1221 T1432 T1446 arg1Of be,","
R1222 T1432 T1447 arg1Of be,since
R1223 T1433 T1432 arg2Of important,be
R1224 T1433 T1434 arg1Of important,for
R1225 T1437 T1434 arg2Of induction,for
R1226 T1437 T1435 arg1Of induction,the
R1227 T1437 T1436 arg1Of induction,persistent
R1228 T1437 T1438 arg1Of induction,of
R1229 T1440 T1438 arg2Of cells,of
R1230 T1440 T1439 arg1Of cells,these
R1231 T1442 T1441 arg1Of vitro,in
R1232 T1442 T1443 arg1Of vitro,and
R1233 T1445 T1443 arg2Of vivo,and
R1234 T1445 T1444 arg1Of vivo,in
R1235 T1448 T1449 arg1Of animals,lacking
R1236 T1448 T1455 arg1Of animals,have
R1237 T1448 T1464 arg1Of animals,suffer
R1238 T1451 T1449 arg2Of TGF-βRII,lacking
R1239 T1451 T1450 arg1Of TGF-βRII,the
R1240 T1451 T1452 arg1Of TGF-βRII,on
R1241 T1454 T1452 arg2Of cells,on
R1242 T1454 T1453 arg1Of cells,T
R1243 T1455 T1460 arg1Of have,[
R1244 T1455 T1463 arg1Of have,and
R1245 T1459 T1455 arg2Of cells,have
R1246 T1459 T1456 arg1Of cells,fewer
R1247 T1459 T1457 arg1Of cells,peripherally
R1248 T1459 T1458 arg1Of cells,iTreg
R1249 T1461 T1460 arg2Of 15,[
R1250 T1462 T1460 arg3Of ],[
R1251 T1463 T1447 arg2Of and,since
R1252 T1463 T1472 arg1Of and,[
R1253 T1464 T1463 arg2Of suffer,and
R1254 T1464 T1465 arg1Of suffer,from
R1255 T1471 T1465 arg2Of disease,from
R1256 T1471 T1466 arg1Of disease,a
R1257 T1471 T1467 arg1Of disease,T
R1258 T1471 T1468 arg1Of disease,cell–dependent
R1259 T1471 T1469 arg1Of disease,multiorgan
R1260 T1471 T1470 arg1Of disease,inflammatory
R1261 T1473 T1472 arg2Of 16,[
R1262 T1474 T1472 arg3Of ],[
R1263 T1477 T1476 arg1Of effect,the
R1264 T1477 T1478 arg1Of effect,of
R1265 T1477 T1480 arg1Of effect,on
R1266 T1477 T1487 arg1Of effect,has
R1267 T1477 T1488 arg1Of effect,been
R1268 T1477 T1489 arg2Of effect,demonstrated
R1269 T1479 T1478 arg2Of TGF-β,of
R1270 T1481 T1482 arg1Of natural,and
R1271 T1483 T1482 arg2Of inducible,and
R1272 T1486 T1480 arg2Of induction,on
R1273 T1486 T1481 arg1Of induction,natural
R1274 T1486 T1483 arg1Of induction,inducible
R1275 T1486 T1484 arg1Of induction,Treg
R1276 T1486 T1485 arg1Of induction,cell
R1277 T1489 T1475 arg2Of demonstrated,Although
R1278 T1489 T1487 arg2Of demonstrated,has
R1279 T1489 T1488 arg2Of demonstrated,been
R1280 T1489 T1490 arg1Of demonstrated,repeatedly
R1281 T1489 T1491 arg1Of demonstrated,[
R1282 T1492 T1491 arg2Of "15,17",[
R1283 T1493 T1491 arg3Of ],[
R1284 T1497 T1495 arg1Of mechanisms,its
R1285 T1497 T1496 arg1Of mechanisms,molecular
R1286 T1497 T1498 arg1Of mechanisms,remain
R1287 T1497 T1500 arg1Of mechanisms,be
R1288 T1497 T1501 arg2Of mechanisms,identified
R1289 T1498 T1475 arg1Of remain,Although
R1290 T1498 T1494 arg1Of remain,","
R1291 T1501 T1498 arg2Of identified,remain
R1292 T1501 T1499 arg1Of identified,to
R1293 T1501 T1500 arg2Of identified,be
R1294 T1504 T1502 arg1Of study,The
R1295 T1504 T1503 arg1Of study,current
R1296 T1504 T1505 arg1Of study,provides
R1297 T1506 T1505 arg2Of evidence,provides
R1298 T1508 T1509 arg1Of GATA3,and
R1299 T1509 T1511 arg1Of and,play
R1300 T1510 T1509 arg2Of FOXP3,and
R1301 T1511 T1506 arg2Of play,evidence
R1302 T1511 T1507 arg1Of play,that
R1303 T1511 T1515 arg1Of play,in
R1304 T1511 T1528 arg1Of play,","
R1305 T1511 T1529 arg1Of play,respectively
R1306 T1514 T1511 arg2Of role,play
R1307 T1514 T1512 arg1Of role,a
R1308 T1514 T1513 arg1Of role,competitive
R1309 T1518 T1515 arg2Of commitment,in
R1310 T1518 T1516 arg1Of commitment,iTreg
R1311 T1518 T1517 arg1Of commitment,cell
R1312 T1518 T1519 arg1Of commitment,as
R1313 T1520 T1521 arg1Of T-bet,and
R1314 T1521 T1519 arg2Of and,as
R1315 T1521 T1523 arg1Of and,for
R1316 T1522 T1521 arg2Of GATA3,and
R1317 T1524 T1525 arg1Of Th1,and
R1318 T1526 T1525 arg2Of Th2,and
R1319 T1527 T1523 arg2Of differentiation,for
R1320 T1527 T1524 arg1Of differentiation,Th1
R1321 T1527 T1526 arg1Of differentiation,Th2
R1322 T1530 T1531 arg1Of We,show
R1323 T1533 T1534 arg1Of GATA3,inhibits
R1324 T1534 T1532 arg1Of inhibits,that
R1325 T1534 T1537 arg1Of inhibits,and
R1326 T1536 T1534 arg2Of induction,inhibits
R1327 T1536 T1535 arg1Of induction,FOXP3
R1328 T1537 T1531 arg2Of and,show
R1329 T1538 T1537 arg2Of that,and
R1330 T1539 T1540 arg1Of IL-4,limits
R1331 T1540 T1538 arg2Of limits,that
R1332 T1540 T1543 arg1Of limits,in
R1333 T1540 T1547 arg1Of limits,","
R1334 T1540 T1550 arg1Of limits,vitro
R1335 T1540 T1553 arg1Of limits,vivo
R1336 T1542 T1540 arg2Of expression,limits
R1337 T1542 T1541 arg1Of expression,FOXP3
R1338 T1546 T1543 arg2Of way,in
R1339 T1546 T1544 arg1Of way,a
R1340 T1546 T1545 arg1Of way,GATA3-mediated
R1341 T1550 T1549 arg1Of vitro,in
R1342 T1550 T1551 arg1Of vitro,and
R1343 T1551 T1548 arg1Of and,both
R1344 T1553 T1551 arg2Of vivo,and
R1345 T1553 T1552 arg1Of vivo,in
R1346 T1554 T1556 arg1Of We,show
R1347 T1556 T1555 arg1Of show,also
R1348 T1558 T1560 arg1Of GATA3,binds
R1349 T1558 T1567 arg1Of GATA3,prevents
R1350 T1560 T1561 arg1Of binds,to
R1351 T1560 T1565 arg1Of binds,and
R1352 T1564 T1561 arg2Of promoter,to
R1353 T1564 T1562 arg1Of promoter,the
R1354 T1564 T1563 arg1Of promoter,FOXP3
R1355 T1565 T1556 arg2Of and,show
R1356 T1565 T1557 arg1Of and,that
R1357 T1565 T1559 arg1Of and,directly
R1358 T1567 T1565 arg2Of prevents,and
R1359 T1567 T1566 arg1Of prevents,thereby
R1360 T1567 T1573 arg1Of prevents,","
R1361 T1569 T1567 arg2Of induction,prevents
R1362 T1569 T1568 arg1Of induction,the
R1363 T1569 T1570 arg1Of induction,of
R1364 T1572 T1570 arg2Of gene,of
R1365 T1572 T1571 arg1Of gene,this
R1366 T1574 T1567 arg3Of demonstrating,prevents
R1367 T1577 T1576 arg1Of differentiation,Th2
R1368 T1577 T1578 arg1Of differentiation,overrules
R1369 T1578 T1574 arg2Of overrules,demonstrating
R1370 T1578 T1575 arg1Of overrules,that
R1371 T1580 T1578 arg2Of induction,overrules
R1372 T1580 T1579 arg1Of induction,iTreg

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T1581 3361-3370 Anaphor denotes this gene
T1582 3308-3313 Antecedent denotes FOXP3
R1373 T1581 T1582 boundBy this gene,FOXP3

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T1634 13-22 JJ denotes Effective
T1635 23-29 JJ denotes immune
T1636 30-39 NNS denotes responses
T1637 40-43 VBP denotes are
T1638 44-57 VBN denotes characterized
T1639 58-60 IN denotes by
T1640 61-62 NNP denotes T
T1641 63-67 NN denotes cell
T1642 68-78 NN denotes activation
T1643 78-79 , denotes ,
T1644 80-85 WDT denotes which
T1645 86-93 VBZ denotes directs
T1646 94-102 JJ denotes adaptive
T1647 103-106 CC denotes and
T1648 107-113 JJ denotes innate
T1649 114-120 JJ denotes immune
T1650 121-130 NNS denotes responses
T1651 131-133 TO denotes to
T1652 134-138 VB denotes kill
T1653 139-148 NNS denotes pathogens
T1654 149-160 RB denotes efficiently
T1655 160-161 . denotes .
T1656 162-171 JJ denotes Dependent
T1657 172-174 IN denotes on
T1658 175-178 DT denotes the
T1659 179-187 NN denotes pathogen
T1660 187-188 , denotes ,
T1661 189-190 NNP denotes T
T1662 191-196 NNS denotes cells
T1663 197-210 VBP denotes differentiate
T1664 211-215 IN denotes into
T1665 216-225 JJ denotes different
T1666 226-234 NNS denotes subtypes
T1667 234-235 , denotes ,
T1668 236-240 JJ denotes such
T1669 241-243 IN denotes as
T1670 244-247 CD denotes Th1
T1671 248-250 CC denotes or
T1672 251-254 CD denotes Th2
T1673 255-260 NNS denotes cells
T1674 260-261 , denotes ,
T1675 262-267 WDT denotes which
T1676 268-271 VBP denotes are
T1677 272-276 RBS denotes most
T1678 277-286 JJ denotes efficient
T1679 287-289 IN denotes in
T1680 290-299 VBG denotes defeating
T1681 300-309 JJ denotes microbial
T1682 310-312 CC denotes or
T1683 313-322 JJ denotes parasitic
T1684 323-331 NNS denotes invaders
T1685 332-344 RB denotes respectively
T1686 344-345 . denotes .
T1687 346-347 DT denotes A
T1688 348-356 NN denotes hallmark
T1689 357-359 IN denotes of
T1690 360-363 CD denotes Th1
T1691 364-367 CC denotes and
T1692 368-371 CD denotes Th2
T1693 372-387 NN denotes differentiation
T1694 388-396 NNS denotes pathways
T1695 397-399 VBZ denotes is
T1696 400-403 DT denotes the
T1697 404-417 NN denotes exclusiveness
T1698 418-420 IN denotes of
T1699 421-424 DT denotes the
T1700 425-435 JJ denotes individual
T1701 436-445 NN denotes phenotype
T1702 446-453 VBG denotes leading
T1703 454-456 TO denotes to
T1704 457-463 DT denotes either
T1705 464-467 CD denotes Th1
T1706 468-470 CC denotes or
T1707 471-474 CD denotes Th2
T1708 474-475 , denotes ,
T1709 476-479 CC denotes but
T1710 480-483 RB denotes not
T1711 484-486 TO denotes to
T1712 487-492 JJ denotes mixed
T1713 493-504 NNS denotes populations
T1714 504-505 . denotes .
T1715 506-509 DT denotes The
T1716 510-523 NN denotes exclusiveness
T1717 524-526 IN denotes of
T1718 527-531 DT denotes this
T1719 532-541 NN denotes mechanism
T1720 542-544 VBZ denotes is
T1721 545-553 VBN denotes provided
T1722 554-556 IN denotes by
T1723 557-558 DT denotes a
T1724 559-571 NN denotes polarization
T1725 572-579 NN denotes process
T1726 579-580 , denotes ,
T1727 581-586 WRB denotes where
T1728 587-590 JJ denotes Th2
T1729 591-606 NN denotes differentiation
T1730 607-615 VBZ denotes inhibits
T1731 616-619 JJ denotes Th1
T1732 620-630 NN denotes commitment
T1733 631-634 CC denotes and
T1734 635-639 NN denotes vice
T1735 640-645 RB denotes versa
T1736 645-646 . denotes .
T1737 647-659 RB denotes Specifically
T1738 660-671 VBG denotes interleukin
T1739 672-673 CD denotes 4
T1740 674-675 -LRB- denotes (
T1741 675-679 NN denotes IL-4
T1742 679-680 -RRB- denotes )
T1743 681-688 VBD denotes induced
T1744 689-694 NNP denotes STAT6
T1745 695-698 CC denotes and
T1746 699-704 NNP denotes GATA3
T1747 705-712 VBP denotes inhibit
T1748 713-728 NN denotes differentiation
T1749 729-733 IN denotes into
T1750 734-737 JJ denotes Th1
T1751 738-743 NNS denotes cells
T1752 744-746 IN denotes in
T1753 747-750 DT denotes the
T1754 751-756 JJ denotes early
T1755 757-762 NN denotes phase
T1756 763-765 IN denotes of
T1757 766-776 NN denotes commitment
T1758 777-778 NNP denotes [
T1759 778-781 CD denotes 1,2
T1760 781-782 NNP denotes ]
T1761 782-783 . denotes .
T1762 784-789 CD denotes GATA3
T1763 790-792 VBZ denotes is
T1764 793-803 JJ denotes sufficient
T1765 804-806 TO denotes to
T1766 807-813 VB denotes induce
T1767 814-815 DT denotes a
T1768 816-819 JJ denotes Th2
T1769 820-829 NN denotes phenotype
T1770 830-831 NN denotes [
T1771 831-832 CD denotes 3
T1772 832-833 NNP denotes ]
T1773 834-837 CC denotes and
T1774 838-842 VBZ denotes acts
T1775 843-846 RB denotes not
T1776 847-851 RB denotes only
T1777 852-859 IN denotes through
T1778 860-863 DT denotes the
T1779 864-873 NN denotes induction
T1780 874-876 IN denotes of
T1781 877-881 NN denotes IL-4
T1782 881-882 , denotes ,
T1783 883-887 NN denotes IL-5
T1784 888-891 CC denotes and
T1785 892-897 NN denotes IL-13
T1786 897-898 , denotes ,
T1787 899-902 DT denotes the
T1788 903-906 NNP denotes Th2
T1789 907-916 NNS denotes cytokines
T1790 916-917 , denotes ,
T1791 918-921 CC denotes but
T1792 922-926 RB denotes also
T1793 927-934 IN denotes through
T1794 935-938 DT denotes the
T1795 939-949 NN denotes inhibition
T1796 950-952 IN denotes of
T1797 953-956 CD denotes Th1
T1798 957-970 JJ denotes cell-specific
T1799 971-978 NNS denotes factors
T1800 979-980 VBP denotes [
T1801 980-981 CD denotes 3
T1802 981-982 NNP denotes ]
T1803 982-983 . denotes .
T1804 984-992 RB denotes Recently
T1805 992-993 , denotes ,
T1806 994-996 PRP denotes it
T1807 997-1000 VBD denotes was
T1808 1001-1006 VBN denotes shown
T1809 1007-1011 IN denotes that
T1810 1012-1017 JJ denotes T-bet
T1811 1018-1026 RB denotes directly
T1812 1027-1036 VBZ denotes modulates
T1813 1037-1042 CD denotes GATA3
T1814 1043-1051 NN denotes function
T1815 1051-1052 , denotes ,
T1816 1053-1063 VBG denotes suggesting
T1817 1064-1068 IN denotes that
T1818 1069-1082 NN denotes transcription
T1819 1083-1090 NNS denotes factors
T1820 1091-1098 VBP denotes compete
T1821 1099-1101 IN denotes in
T1822 1102-1105 DT denotes the
T1823 1106-1111 JJ denotes early
T1824 1112-1127 NN denotes differentiation
T1825 1128-1133 NN denotes phase
T1826 1134-1136 IN denotes of
T1827 1137-1138 NNP denotes T
T1828 1139-1144 NNS denotes cells
T1829 1144-1145 , denotes ,
T1830 1146-1157 RB denotes potentially
T1831 1158-1169 VBG denotes integrating
T1832 1170-1183 JJ denotes environmental
T1833 1184-1191 NNS denotes signals
T1834 1192-1194 TO denotes to
T1835 1195-1202 RB denotes finally
T1836 1203-1210 VB denotes imprint
T1837 1211-1214 DT denotes the
T1838 1215-1216 NNP denotes T
T1839 1217-1221 NN denotes cell
T1840 1222-1231 NN denotes phenotype
T1841 1232-1233 NNP denotes [
T1842 1233-1236 CD denotes 4,5
T1843 1236-1237 NNP denotes ]
T1844 1237-1238 . denotes .
T1845 1239-1240 DT denotes A
T1846 1241-1256 JJ denotes GATA3-dominated
T1847 1257-1263 JJ denotes immune
T1848 1264-1272 NN denotes response
T1849 1273-1276 VBZ denotes has
T1850 1277-1281 VBN denotes been
T1851 1282-1287 VBN denotes shown
T1852 1288-1290 TO denotes to
T1853 1291-1293 VB denotes be
T1854 1294-1303 JJ denotes essential
T1855 1304-1306 IN denotes in
T1856 1307-1313 NN denotes airway
T1857 1314-1332 NN denotes hyperresonsiveness
T1858 1333-1334 NNP denotes [
T1859 1334-1335 CD denotes 6
T1860 1335-1336 NNP denotes ]
T1861 1337-1340 CC denotes and
T1862 1341-1345 NN denotes IL-4
T1863 1346-1355 VBD denotes dominated
T1864 1356-1365 NNS denotes responses
T1865 1366-1369 MD denotes can
T1866 1370-1375 VB denotes break
T1867 1376-1392 JJ denotes antigen-specific
T1868 1393-1399 JJ denotes immune
T1869 1400-1409 NN denotes tolerance
T1870 1410-1411 NN denotes [
T1871 1411-1412 CD denotes 7
T1872 1412-1413 NNP denotes ]
T1873 1413-1414 . denotes .
T1874 1415-1429 NNP denotes Overexpression
T1875 1430-1432 IN denotes of
T1876 1433-1434 DT denotes a
T1877 1435-1443 JJ denotes dominant
T1878 1444-1452 JJ denotes negative
T1879 1453-1457 NN denotes form
T1880 1458-1460 IN denotes of
T1881 1461-1466 NNP denotes GATA3
T1882 1467-1468 NNP denotes [
T1883 1468-1469 CD denotes 8
T1884 1469-1470 NNP denotes ]
T1885 1471-1473 CC denotes or
T1886 1474-1483 NN denotes treatment
T1887 1484-1488 IN denotes with
T1888 1489-1507 JJ denotes antisense-mediated
T1889 1508-1513 NNP denotes GATA3
T1890 1514-1522 NN denotes blockade
T1891 1523-1524 NN denotes [
T1892 1524-1525 CD denotes 9
T1893 1525-1526 NNP denotes ]
T1894 1527-1536 VBD denotes decreased
T1895 1537-1540 DT denotes the
T1896 1541-1549 NN denotes severity
T1897 1550-1552 IN denotes of
T1898 1553-1556 DT denotes the
T1899 1557-1565 JJ denotes allergic
T1900 1566-1572 NN denotes airway
T1901 1573-1593 NN denotes hyper-responsiveness
T1902 1593-1594 . denotes .
T1903 1595-1598 DT denotes The
T1904 1599-1608 NN denotes discovery
T1905 1609-1611 IN denotes of
T1906 1612-1622 JJ denotes regulatory
T1907 1623-1624 NNP denotes T
T1908 1625-1626 -LRB- denotes (
T1909 1626-1630 NNP denotes Treg
T1910 1630-1631 -RRB- denotes )
T1911 1632-1637 NNS denotes cells
T1912 1638-1648 VBZ denotes highlights
T1913 1649-1656 DT denotes another
T1914 1657-1666 NN denotes phenotype
T1915 1667-1669 IN denotes of
T1916 1670-1671 NNP denotes T
T1917 1672-1677 NNS denotes cells
T1918 1677-1678 , denotes ,
T1919 1679-1684 WDT denotes which
T1920 1685-1687 VBZ denotes is
T1921 1688-1697 JJ denotes essential
T1922 1698-1701 IN denotes for
T1923 1702-1711 NN denotes tolerance
T1924 1712-1719 IN denotes against
T1925 1720-1733 NNS denotes self-antigens
T1926 1733-1734 . denotes .
T1927 1735-1744 RB denotes Naturally
T1928 1745-1754 VBG denotes occurring
T1929 1754-1755 , denotes ,
T1930 1756-1770 JJ denotes thymus-derived
T1931 1771-1775 NNP denotes Treg
T1932 1776-1777 -LRB- denotes (
T1933 1777-1782 NNP denotes nTreg
T1934 1782-1783 -RRB- denotes )
T1935 1784-1789 NNS denotes cells
T1936 1790-1793 VBP denotes are
T1937 1794-1803 VBN denotes generated
T1938 1804-1806 IN denotes in
T1939 1807-1810 DT denotes the
T1940 1811-1817 NN denotes thymus
T1941 1818-1821 CC denotes and
T1942 1822-1825 VBP denotes are
T1943 1826-1833 VBN denotes assumed
T1944 1834-1836 TO denotes to
T1945 1837-1844 VB denotes protect
T1946 1845-1852 IN denotes against
T1947 1853-1856 DT denotes the
T1948 1857-1865 NN denotes activity
T1949 1866-1868 IN denotes of
T1950 1869-1881 JJ denotes autoreactive
T1951 1882-1883 NNP denotes T
T1952 1884-1889 NNS denotes cells
T1953 1890-1892 IN denotes in
T1954 1893-1896 DT denotes the
T1955 1897-1906 NN denotes periphery
T1956 1906-1907 . denotes .
T1957 1908-1913 DT denotes These
T1958 1914-1919 NNS denotes cells
T1959 1920-1927 VBP denotes express
T1960 1928-1931 DT denotes the
T1961 1932-1940 NN denotes forkhead
T1962 1941-1954 NN denotes transcription
T1963 1955-1961 NN denotes factor
T1964 1962-1967 CD denotes FOXP3
T1965 1968-1971 CC denotes and
T1966 1972-1986 RB denotes constitutively
T1967 1987-1994 JJ denotes express
T1968 1995-1999 NNS denotes CD25
T1969 2000-2002 IN denotes on
T1970 2003-2008 PRP$ denotes their
T1971 2009-2016 NN denotes surface
T1972 2016-2017 , denotes ,
T1973 2018-2021 CC denotes but
T1974 2022-2026 PRP denotes they
T1975 2027-2031 VBP denotes lack
T1976 2032-2042 NN denotes expression
T1977 2043-2045 IN denotes of
T1978 2046-2049 CD denotes Th1
T1979 2050-2052 CC denotes or
T1980 2053-2056 CD denotes Th2
T1981 2057-2066 NNS denotes cytokines
T1982 2066-2067 . denotes .
T1983 2068-2080 RB denotes Particularly
T1984 2081-2092 JJ denotes interesting
T1985 2093-2096 VBP denotes are
T1986 2097-2102 DT denotes those
T1987 2103-2107 NNP denotes Treg
T1988 2108-2113 NNS denotes cells
T1989 2114-2118 WDT denotes that
T1990 2119-2122 VBP denotes are
T1991 2123-2132 VBN denotes generated
T1992 2133-2135 IN denotes in
T1993 2136-2139 DT denotes the
T1994 2140-2149 NN denotes periphery
T1995 2150-2153 CC denotes and
T1996 2154-2158 RB denotes thus
T1997 2159-2162 VBP denotes are
T1998 2163-2172 JJ denotes potential
T1999 2173-2180 NNS denotes targets
T2000 2181-2184 IN denotes for
T2001 2185-2196 JJ denotes therapeutic
T2002 2197-2210 NNS denotes interventions
T2003 2210-2211 . denotes .
T2004 2212-2217 DT denotes These
T2005 2218-2225 JJ denotes induced
T2006 2226-2230 NNP denotes Treg
T2007 2231-2232 -LRB- denotes (
T2008 2232-2237 NNP denotes iTreg
T2009 2237-2238 -RRB- denotes )
T2010 2239-2244 NNS denotes cells
T2011 2245-2249 VBD denotes were
T2012 2250-2258 VBN denotes reported
T2013 2259-2261 TO denotes to
T2014 2262-2269 VB denotes express
T2015 2270-2275 CD denotes FOXP3
T2016 2276-2277 NNP denotes [
T2017 2277-2279 CD denotes 10
T2018 2279-2280 NNP denotes ]
T2019 2280-2281 . denotes .
T2020 2282-2285 DT denotes The
T2021 2286-2291 JJ denotes exact
T2022 2292-2302 NNS denotes mechanisms
T2023 2303-2305 IN denotes of
T2024 2306-2311 NNP denotes iTreg
T2025 2312-2322 NN denotes generation
T2026 2323-2326 VBP denotes are
T2027 2327-2334 JJ denotes unclear
T2028 2334-2335 , denotes ,
T2029 2336-2339 CC denotes but
T2030 2340-2341 NNP denotes T
T2031 2342-2346 NN denotes cell
T2032 2347-2355 NN denotes receptor
T2033 2356-2357 -LRB- denotes (
T2034 2357-2360 NNP denotes TCR
T2035 2360-2361 -RRB- denotes )
T2036 2362-2372 VBG denotes triggering
T2037 2373-2376 VBZ denotes has
T2038 2377-2381 VBN denotes been
T2039 2382-2387 VBN denotes shown
T2040 2388-2390 TO denotes to
T2041 2391-2397 VB denotes induce
T2042 2398-2403 CD denotes FOXP3
T2043 2404-2414 NN denotes expression
T2044 2415-2418 CC denotes and
T2045 2419-2430 JJ denotes suppressive
T2046 2431-2436 NNS denotes cells
T2047 2437-2439 IN denotes in
T2048 2440-2445 JJ denotes human
T2049 2446-2447 NNP denotes [
T2050 2447-2452 CD denotes 11,12
T2051 2452-2453 NNP denotes ]
T2052 2453-2454 , denotes ,
T2053 2455-2462 RB denotes however
T2054 2463-2466 DT denotes the
T2055 2467-2476 NN denotes phenotype
T2056 2477-2484 VBZ denotes appears
T2057 2485-2487 TO denotes to
T2058 2488-2490 VB denotes be
T2059 2491-2493 IN denotes of
T2060 2494-2503 JJ denotes transient
T2061 2504-2510 NN denotes nature
T2062 2511-2512 NNP denotes [
T2063 2512-2517 CD denotes 13,14
T2064 2517-2518 NNP denotes ]
T2065 2518-2519 . denotes .
T2066 2520-2525 NNP denotes TGF-β
T2067 2526-2529 VBZ denotes has
T2068 2530-2534 VBN denotes been
T2069 2535-2547 VBN denotes demonstrated
T2070 2548-2550 TO denotes to
T2071 2551-2553 VB denotes be
T2072 2554-2563 JJ denotes important
T2073 2564-2567 IN denotes for
T2074 2568-2571 DT denotes the
T2075 2572-2582 JJ denotes persistent
T2076 2583-2592 NN denotes induction
T2077 2593-2595 IN denotes of
T2078 2596-2601 DT denotes these
T2079 2602-2607 NNS denotes cells
T2080 2608-2610 IN denotes in
T2081 2611-2616 NN denotes vitro
T2082 2617-2620 CC denotes and
T2083 2621-2623 IN denotes in
T2084 2624-2628 NN denotes vivo
T2085 2628-2629 , denotes ,
T2086 2630-2635 IN denotes since
T2087 2636-2643 NNS denotes animals
T2088 2644-2651 VBG denotes lacking
T2089 2652-2655 DT denotes the
T2090 2656-2664 NNP denotes TGF-βRII
T2091 2665-2667 IN denotes on
T2092 2668-2669 NNP denotes T
T2093 2670-2675 NNS denotes cells
T2094 2676-2680 VBP denotes have
T2095 2681-2686 JJR denotes fewer
T2096 2687-2699 RB denotes peripherally
T2097 2700-2705 JJ denotes iTreg
T2098 2706-2711 NNS denotes cells
T2099 2712-2713 NNP denotes [
T2100 2713-2715 CD denotes 15
T2101 2715-2716 NNP denotes ]
T2102 2717-2720 CC denotes and
T2103 2721-2727 VBP denotes suffer
T2104 2728-2732 IN denotes from
T2105 2733-2734 DT denotes a
T2106 2735-2736 NNP denotes T
T2107 2737-2741 NN denotes cell
T2108 2742-2751 JJ denotes dependent
T2109 2752-2762 JJ denotes multiorgan
T2110 2763-2775 JJ denotes inflammatory
T2111 2776-2783 NN denotes disease
T2112 2784-2785 NNP denotes [
T2113 2785-2787 CD denotes 16
T2114 2787-2788 NNP denotes ]
T2115 2788-2789 . denotes .
T2116 2790-2798 IN denotes Although
T2117 2799-2802 DT denotes the
T2118 2803-2809 NN denotes effect
T2119 2810-2812 IN denotes of
T2120 2813-2818 NNP denotes TGF-β
T2121 2819-2821 IN denotes on
T2122 2822-2829 JJ denotes natural
T2123 2830-2833 CC denotes and
T2124 2834-2843 JJ denotes inducible
T2125 2844-2848 NNP denotes Treg
T2126 2849-2853 NN denotes cell
T2127 2854-2863 NN denotes induction
T2128 2864-2867 VBZ denotes has
T2129 2868-2872 VBN denotes been
T2130 2873-2885 VBN denotes demonstrated
T2131 2886-2896 RB denotes repeatedly
T2132 2897-2898 NNP denotes [
T2133 2898-2903 CD denotes 15,17
T2134 2903-2904 NNP denotes ]
T2135 2904-2905 , denotes ,
T2136 2906-2909 PRP$ denotes its
T2137 2910-2919 JJ denotes molecular
T2138 2920-2930 NNS denotes mechanisms
T2139 2931-2937 VBP denotes remain
T2140 2938-2940 TO denotes to
T2141 2941-2943 VB denotes be
T2142 2944-2954 VBN denotes identified
T2143 2954-2955 . denotes .
T2144 2956-2959 DT denotes The
T2145 2960-2967 JJ denotes current
T2146 2968-2973 NN denotes study
T2147 2974-2982 VBZ denotes provides
T2148 2983-2991 NN denotes evidence
T2149 2992-2996 IN denotes that
T2150 2997-3002 NNP denotes GATA3
T2151 3003-3006 CC denotes and
T2152 3007-3012 NNP denotes FOXP3
T2153 3013-3017 VBP denotes play
T2154 3018-3019 DT denotes a
T2155 3020-3031 JJ denotes competitive
T2156 3032-3036 NN denotes role
T2157 3037-3039 IN denotes in
T2158 3040-3045 NNP denotes iTreg
T2159 3046-3050 NN denotes cell
T2160 3051-3061 NN denotes commitment
T2161 3062-3064 IN denotes as
T2162 3065-3070 NNP denotes T-bet
T2163 3071-3074 CC denotes and
T2164 3075-3080 NNP denotes GATA3
T2165 3081-3084 IN denotes for
T2166 3085-3088 NNP denotes Th1
T2167 3089-3092 CC denotes and
T2168 3093-3096 NNP denotes Th2
T2169 3097-3112 NN denotes differentiation
T2170 3112-3113 , denotes ,
T2171 3114-3126 RB denotes respectively
T2172 3126-3127 . denotes .
T2173 3128-3130 PRP denotes We
T2174 3131-3135 VBP denotes show
T2175 3136-3140 IN denotes that
T2176 3141-3146 NNP denotes GATA3
T2177 3147-3155 VBZ denotes inhibits
T2178 3156-3161 CD denotes FOXP3
T2179 3162-3171 NN denotes induction
T2180 3172-3175 CC denotes and
T2181 3176-3180 IN denotes that
T2182 3181-3185 NN denotes IL-4
T2183 3186-3192 NNS denotes limits
T2184 3193-3198 CD denotes FOXP3
T2185 3199-3209 NN denotes expression
T2186 3210-3212 IN denotes in
T2187 3213-3214 DT denotes a
T2188 3215-3229 JJ denotes GATA3-mediated
T2189 3230-3233 NN denotes way
T2190 3233-3234 , denotes ,
T2191 3235-3239 DT denotes both
T2192 3240-3242 IN denotes in
T2193 3243-3248 NN denotes vitro
T2194 3249-3252 CC denotes and
T2195 3253-3255 IN denotes in
T2196 3256-3260 NN denotes vivo
T2197 3260-3261 . denotes .
T2198 3262-3264 PRP denotes We
T2199 3265-3269 RB denotes also
T2200 3270-3274 VBP denotes show
T2201 3275-3279 IN denotes that
T2202 3280-3285 CD denotes GATA3
T2203 3286-3294 RB denotes directly
T2204 3295-3300 VBZ denotes binds
T2205 3301-3303 TO denotes to
T2206 3304-3307 DT denotes the
T2207 3308-3313 CD denotes FOXP3
T2208 3314-3322 NN denotes promoter
T2209 3323-3326 CC denotes and
T2210 3327-3334 RB denotes thereby
T2211 3335-3343 VBZ denotes prevents
T2212 3344-3347 DT denotes the
T2213 3348-3357 NN denotes induction
T2214 3358-3360 IN denotes of
T2215 3361-3365 DT denotes this
T2216 3366-3370 NN denotes gene
T2217 3370-3371 , denotes ,
T2218 3372-3385 VBG denotes demonstrating
T2219 3386-3390 IN denotes that
T2220 3391-3394 JJ denotes Th2
T2221 3395-3410 NN denotes differentiation
T2222 3411-3420 NNS denotes overrules
T2223 3421-3426 NNP denotes iTreg
T2224 3427-3436 NN denotes induction
T2225 3436-3437 . denotes .
R1374 T1634 T1636 amod Effective,responses
R1375 T1635 T1636 amod immune,responses
R1376 T1636 T1638 nsubjpass responses,characterized
R1377 T1637 T1638 auxpass are,characterized
R1378 T1638 T1638 ROOT characterized,characterized
R1379 T1639 T1638 agent by,characterized
R1380 T1640 T1642 compound T,activation
R1381 T1641 T1642 compound cell,activation
R1382 T1642 T1639 pobj activation,by
R1383 T1643 T1642 punct ",",activation
R1384 T1644 T1645 nsubj which,directs
R1385 T1645 T1642 relcl directs,activation
R1386 T1646 T1645 acomp adaptive,directs
R1387 T1647 T1646 cc and,adaptive
R1388 T1648 T1646 conj innate,adaptive
R1389 T1649 T1650 amod immune,responses
R1390 T1650 T1645 dobj responses,directs
R1391 T1651 T1652 aux to,kill
R1392 T1652 T1650 acl kill,responses
R1393 T1653 T1652 dobj pathogens,kill
R1394 T1654 T1652 advmod efficiently,kill
R1395 T1655 T1638 punct .,characterized
R1396 T1656 T1663 advcl Dependent,differentiate
R1397 T1657 T1656 prep on,Dependent
R1398 T1658 T1659 det the,pathogen
R1399 T1659 T1657 pobj pathogen,on
R1400 T1660 T1663 punct ",",differentiate
R1401 T1661 T1662 compound T,cells
R1402 T1662 T1663 nsubj cells,differentiate
R1403 T1663 T1663 ROOT differentiate,differentiate
R1404 T1664 T1663 prep into,differentiate
R1405 T1665 T1666 amod different,subtypes
R1406 T1666 T1664 pobj subtypes,into
R1407 T1667 T1666 punct ",",subtypes
R1408 T1668 T1669 amod such,as
R1409 T1669 T1666 prep as,subtypes
R1445 T1705 T1703 pobj Th1,to
R1446 T1706 T1705 cc or,Th1
R1447 T1707 T1705 conj Th2,Th1
R1448 T1708 T1697 punct ",",exclusiveness
R1449 T1709 T1697 cc but,exclusiveness
R1450 T1710 T1712 neg not,mixed
R1451 T1711 T1712 aux to,mixed
R1452 T1712 T1697 conj mixed,exclusiveness
R1453 T1713 T1712 dobj populations,mixed
R1454 T1714 T1695 punct .,is
R1455 T1715 T1716 det The,exclusiveness
R1456 T1716 T1721 nsubjpass exclusiveness,provided
R1457 T1717 T1716 prep of,exclusiveness
R1458 T1718 T1719 det this,mechanism
R1459 T1719 T1717 pobj mechanism,of
R1460 T1720 T1721 auxpass is,provided
R1461 T1721 T1721 ROOT provided,provided
R1462 T1722 T1721 agent by,provided
R1463 T1723 T1725 det a,process
R1464 T1724 T1725 compound polarization,process
R1465 T1725 T1722 pobj process,by
R1466 T1726 T1725 punct ",",process
R1467 T1727 T1730 advmod where,inhibits
R1468 T1728 T1729 amod Th2,differentiation
R1469 T1729 T1730 nsubj differentiation,inhibits
R1470 T1730 T1725 relcl inhibits,process
R1471 T1731 T1732 amod Th1,commitment
R1472 T1732 T1730 dobj commitment,inhibits
R1473 T1733 T1732 cc and,commitment
R1474 T1734 T1735 advmod vice,versa
R1475 T1735 T1732 conj versa,commitment
R1476 T1736 T1721 punct .,provided
R1477 T1737 T1738 advmod Specifically,interleukin
R1478 T1738 T1738 ROOT interleukin,interleukin
R1479 T1739 T1738 nummod 4,interleukin
R1480 T1740 T1741 punct (,IL-4
R1481 T1741 T1743 nsubj IL-4,induced
R1482 T1742 T1741 punct ),IL-4
R1483 T1743 T1743 ROOT induced,induced
R1484 T1744 T1743 dobj STAT6,induced
R1485 T1745 T1744 cc and,STAT6
R1486 T1746 T1744 conj GATA3,STAT6
R1487 T1747 T1743 conj inhibit,induced
R1488 T1748 T1747 dobj differentiation,inhibit
R1489 T1749 T1748 prep into,differentiation
R1490 T1750 T1751 amod Th1,cells
R1491 T1751 T1749 pobj cells,into
R1492 T1752 T1748 prep in,differentiation
R1493 T1753 T1755 det the,phase
R1494 T1754 T1755 amod early,phase
R1495 T1755 T1752 pobj phase,in
R1496 T1756 T1755 prep of,phase
R1497 T1757 T1756 pobj commitment,of
R1498 T1758 T1760 compound [,]
R1499 T1759 T1760 compound "1,2",]
R1500 T1760 T1760 ROOT ],]
R1501 T1761 T1743 punct .,induced
R1502 T1762 T1763 nsubj GATA3,is
R1503 T1763 T1763 ROOT is,is
R1504 T1764 T1763 acomp sufficient,is
R1505 T1765 T1766 aux to,induce
R1506 T1766 T1764 xcomp induce,sufficient
R1507 T1767 T1774 det a,acts
R1508 T1768 T1770 amod Th2,[
R1509 T1769 T1770 compound phenotype,[
R1510 T1770 T1774 nummod [,acts
R1511 T1771 T1770 nummod 3,[
R1512 T1772 T1770 appos ],[
R1513 T1773 T1770 cc and,[
R1514 T1774 T1766 dobj acts,induce
R1515 T1775 T1777 preconj not,through
R1516 T1776 T1775 advmod only,not
R1517 T1777 T1774 prep through,acts
R1518 T1778 T1779 det the,induction
R1519 T1779 T1777 pobj induction,through
R1520 T1780 T1779 prep of,induction
R1521 T1781 T1780 pobj IL-4,of
R1522 T1782 T1781 punct ",",IL-4
R1523 T1783 T1781 conj IL-5,IL-4
R1524 T1784 T1783 cc and,IL-5
R1525 T1785 T1783 conj IL-13,IL-5
R1526 T1786 T1785 punct ",",IL-13
R1527 T1787 T1789 det the,cytokines
R1528 T1788 T1789 compound Th2,cytokines
R1529 T1789 T1779 appos cytokines,induction
R1530 T1790 T1774 punct ",",acts
R1531 T1791 T1774 cc but,acts
R1532 T1792 T1791 advmod also,but
R1533 T1793 T1766 prep through,induce
R1534 T1794 T1795 det the,inhibition
R1535 T1795 T1793 pobj inhibition,through
R1536 T1796 T1795 prep of,inhibition
R1537 T1797 T1799 nummod Th1,factors
R1538 T1798 T1799 amod cell-specific,factors
R1539 T1799 T1796 pobj factors,of
R1540 T1800 T1802 nmod [,]
R1541 T1801 T1802 nummod 3,]
R1542 T1802 T1763 npadvmod ],is
R1543 T1803 T1763 punct .,is
R1544 T1804 T1808 advmod Recently,shown
R1545 T1805 T1808 punct ",",shown
R1546 T1806 T1808 nsubjpass it,shown
R1547 T1807 T1808 auxpass was,shown
R1548 T1808 T1808 ROOT shown,shown
R1549 T1809 T1812 mark that,modulates
R1550 T1810 T1812 nsubj T-bet,modulates
R1551 T1811 T1812 advmod directly,modulates
R1552 T1812 T1808 ccomp modulates,shown
R1553 T1813 T1814 nummod GATA3,function
R1554 T1814 T1812 dobj function,modulates
R1555 T1815 T1808 punct ",",shown
R1556 T1816 T1808 advcl suggesting,shown
R1557 T1817 T1820 mark that,compete
R1558 T1818 T1819 compound transcription,factors
R1559 T1819 T1820 nsubj factors,compete
R1560 T1820 T1816 ccomp compete,suggesting
R1561 T1821 T1820 prep in,compete
R1562 T1822 T1825 det the,phase
R1563 T1823 T1825 amod early,phase
R1564 T1824 T1825 compound differentiation,phase
R1565 T1825 T1821 pobj phase,in
R1566 T1826 T1825 prep of,phase
R1567 T1827 T1828 compound T,cells
R1568 T1828 T1826 pobj cells,of
R1569 T1829 T1820 punct ",",compete
R1570 T1830 T1831 advmod potentially,integrating
R1571 T1831 T1820 advcl integrating,compete
R1572 T1832 T1833 amod environmental,signals
R1573 T1833 T1831 dobj signals,integrating
R1574 T1834 T1836 aux to,imprint
R1575 T1835 T1836 advmod finally,imprint
R1576 T1836 T1831 advcl imprint,integrating
R1577 T1837 T1840 det the,phenotype
R1578 T1838 T1839 compound T,cell
R1579 T1839 T1840 compound cell,phenotype
R1580 T1840 T1836 dobj phenotype,imprint
R1581 T1841 T1843 compound [,]
R1582 T1842 T1843 compound "4,5",]
R1583 T1843 T1840 appos ],phenotype
R1584 T1844 T1808 punct .,shown
R1585 T1845 T1848 det A,response
R1586 T1846 T1848 amod GATA3-dominated,response
R1587 T1847 T1848 amod immune,response
R1588 T1848 T1851 nsubjpass response,shown
R1589 T1849 T1851 aux has,shown
R1590 T1850 T1851 auxpass been,shown
R1591 T1851 T1851 ROOT shown,shown
R1592 T1852 T1853 aux to,be
R1593 T1853 T1851 xcomp be,shown
R1594 T1854 T1853 acomp essential,be
R1595 T1855 T1853 prep in,be
R1596 T1856 T1855 pobj airway,in
R1597 T1857 T1858 compound hyperresonsiveness,[
R1598 T1858 T1856 dobj [,airway
R1599 T1859 T1860 nummod 6,]
R1600 T1860 T1858 appos ],[
R1601 T1861 T1860 cc and,]
R1602 T1862 T1860 conj IL-4,]
R1603 T1863 T1851 conj dominated,shown
R1604 T1864 T1866 nsubj responses,break
R1605 T1865 T1866 aux can,break
R1606 T1866 T1851 conj break,shown
R1607 T1867 T1869 amod antigen-specific,tolerance
R1608 T1868 T1869 amod immune,tolerance
R1609 T1869 T1866 dobj tolerance,break
R1610 T1870 T1872 nmod [,]
R1611 T1871 T1872 nummod 7,]
R1612 T1872 T1869 appos ],tolerance
R1613 T1873 T1866 punct .,break
R1614 T1874 T1894 nsubj Overexpression,decreased
R1615 T1875 T1874 prep of,Overexpression
R1616 T1876 T1879 det a,form
R1617 T1877 T1879 amod dominant,form
R1618 T1878 T1879 amod negative,form
R1619 T1879 T1875 pobj form,of
R1620 T1880 T1879 prep of,form
R1621 T1881 T1882 compound GATA3,[
R1622 T1882 T1884 nmod [,]
R1623 T1883 T1884 nummod 8,]
R1624 T1884 T1886 nmod ],treatment
R1625 T1885 T1884 cc or,]
R1626 T1886 T1880 pobj treatment,of
R1627 T1887 T1886 prep with,treatment
R1628 T1888 T1891 amod antisense-mediated,[
R1629 T1889 T1890 compound GATA3,blockade
R1630 T1890 T1891 compound blockade,[
R1631 T1891 T1893 nmod [,]
R1632 T1892 T1893 nummod 9,]
R1633 T1893 T1887 pobj ],with
R1634 T1894 T1894 ROOT decreased,decreased
R1635 T1895 T1896 det the,severity
R1636 T1896 T1894 dobj severity,decreased
R1637 T1897 T1896 prep of,severity
R1638 T1898 T1901 det the,hyper-responsiveness
R1639 T1899 T1901 amod allergic,hyper-responsiveness
R1640 T1900 T1901 compound airway,hyper-responsiveness
R1641 T1901 T1897 pobj hyper-responsiveness,of
R1642 T1902 T1894 punct .,decreased
R1643 T1903 T1904 det The,discovery
R1644 T1904 T1912 nsubj discovery,highlights
R1645 T1905 T1904 prep of,discovery
R1646 T1906 T1907 amod regulatory,T
R1647 T1907 T1905 pobj T,of
R1648 T1908 T1909 punct (,Treg
R1649 T1909 T1907 appos Treg,T
R1650 T1910 T1907 punct ),T
R1651 T1911 T1905 pobj cells,of
R1652 T1912 T1912 ROOT highlights,highlights
R1653 T1913 T1914 det another,phenotype
R1654 T1914 T1912 dobj phenotype,highlights
R1655 T1915 T1914 prep of,phenotype
R1656 T1916 T1917 compound T,cells
R1657 T1917 T1915 pobj cells,of
R1658 T1918 T1917 punct ",",cells
R1659 T1919 T1920 nsubj which,is
R1660 T1920 T1914 relcl is,phenotype
R1661 T1921 T1920 acomp essential,is
R1662 T1922 T1920 prep for,is
R1663 T1923 T1922 pobj tolerance,for
R1664 T1924 T1923 prep against,tolerance
R1665 T1925 T1924 pobj self-antigens,against
R1666 T1926 T1912 punct .,highlights
R1667 T1927 T1937 advmod Naturally,generated
R1668 T1928 T1937 advcl occurring,generated
R1669 T1929 T1937 punct ",",generated
R1670 T1930 T1931 compound thymus-derived,Treg
R1671 T1931 T1935 poss Treg,cells
R1672 T1932 T1933 punct (,nTreg
R1673 T1933 T1931 appos nTreg,Treg
R1674 T1934 T1931 punct ),Treg
R1675 T1935 T1937 nsubjpass cells,generated
R1676 T1936 T1937 auxpass are,generated
R1677 T1937 T1937 ROOT generated,generated
R1678 T1938 T1937 prep in,generated
R1679 T1939 T1940 det the,thymus
R1680 T1940 T1938 pobj thymus,in
R1718 T1978 T1981 nummod Th1,cytokines
R1719 T1979 T1978 cc or,Th1
R1720 T1980 T1978 conj Th2,Th1
R1721 T1981 T1977 pobj cytokines,of
R1722 T1982 T1959 punct .,express
R1723 T1983 T1984 advmod Particularly,interesting
R1724 T1984 T1985 acomp interesting,are
R1725 T1985 T1985 ROOT are,are
R1726 T1986 T1988 det those,cells
R1727 T2042 T2043 nummod FOXP3,expression
R1728 T1987 T1988 compound Treg,cells
R1729 T2043 T2041 dobj expression,induce
R1730 T2044 T2043 cc and,expression
R1731 T1988 T1985 nsubj cells,are
R1732 T2045 T2046 amod suppressive,cells
R1733 T2046 T2043 conj cells,expression
R1734 T1989 T1991 nsubjpass that,generated
R1735 T2047 T2041 prep in,induce
R1736 T2048 T2049 amod human,[
R1737 T2049 T2051 compound [,]
R1738 T1990 T1991 auxpass are,generated
R1739 T2050 T2051 compound "11,12",]
R1740 T2051 T2047 pobj ],in
R1741 T2052 T2041 punct ",",induce
R1742 T2053 T2056 advmod however,appears
R1743 T2054 T2055 det the,phenotype
R1744 T2055 T2056 nsubj phenotype,appears
R1745 T2056 T2039 conj appears,shown
R1746 T1991 T1988 relcl generated,cells
R1747 T2057 T2058 aux to,be
R1748 T2058 T2056 xcomp be,appears
R1749 T2059 T2058 prep of,be
R1750 T1992 T1991 prep in,generated
R1751 T2060 T2061 amod transient,nature
R1752 T2061 T2059 pobj nature,of
R1753 T2062 T2064 compound [,]
R1754 T2063 T2064 compound "13,14",]
R1755 T1993 T1994 det the,periphery
R1756 T2064 T2056 oprd ],appears
R1757 T2065 T2056 punct .,appears
R1758 T2066 T2069 nsubjpass TGF-β,demonstrated
R1759 T1994 T1992 pobj periphery,in
R1760 T2067 T2069 aux has,demonstrated
R1761 T2068 T2069 auxpass been,demonstrated
R1762 T1995 T1991 cc and,generated
R1763 T2069 T2069 ROOT demonstrated,demonstrated
R1764 T2070 T2071 aux to,be
R1765 T1996 T1997 advmod thus,are
R1766 T2071 T2069 xcomp be,demonstrated
R1767 T2072 T2071 acomp important,be
R1768 T2073 T2071 prep for,be
R1769 T1997 T1985 conj are,are
R1770 T2074 T2076 det the,induction
R1771 T2075 T2076 amod persistent,induction
R1772 T2076 T2073 pobj induction,for
R1773 T2077 T2076 prep of,induction
R1774 T1998 T1999 amod potential,targets
R1775 T2078 T2079 det these,cells
R1776 T2079 T2077 pobj cells,of
R1777 T2080 T2076 prep in,induction
R1778 T1999 T1997 attr targets,are
R1779 T2081 T2080 pobj vitro,in
R1780 T2082 T2080 cc and,in
R1781 T2000 T1999 prep for,targets
R1782 T2083 T2080 conj in,in
R1783 T2084 T2083 pobj vivo,in
R1784 T2085 T2069 punct ",",demonstrated
R1785 T2001 T2002 amod therapeutic,interventions
R1786 T2086 T2094 mark since,have
R1787 T2087 T2094 nsubj animals,have
R1788 T2088 T2087 acl lacking,animals
R1789 T2002 T2000 pobj interventions,for
R1790 T2089 T2090 det the,TGF-βRII
R1791 T2090 T2088 dobj TGF-βRII,lacking
R1792 T2091 T2090 prep on,TGF-βRII
R1793 T2092 T2093 compound T,cells
R1794 T2093 T2091 pobj cells,on
R1795 T2094 T2069 advcl have,demonstrated
R1796 T2003 T1985 punct .,are
R1797 T2095 T2098 amod fewer,cells
R1798 T2096 T2097 advmod peripherally,iTreg
R1799 T2097 T2098 amod iTreg,cells
R1800 T2004 T2006 det These,Treg
R1801 T2098 T2094 dobj cells,have
R1802 T2099 T2099 ROOT [,[
R1803 T2100 T2101 nummod 15,]
R1804 T2005 T2006 amod induced,Treg
R1805 T2101 T2099 dobj ],[
R1806 T2102 T2094 cc and,have
R1807 T2006 T2012 nsubjpass Treg,reported
R1808 T2007 T2006 punct (,Treg
R1809 T2103 T2094 conj suffer,have
R1810 T2104 T2103 prep from,suffer
R1811 T2008 T2006 appos iTreg,Treg
R1812 T2105 T2107 det a,cell
R1813 T2106 T2107 compound T,cell
R1814 T2107 T2104 pobj cell,from
R1815 T2009 T2006 punct ),Treg
R1816 T2108 T2111 amod dependent,disease
R1817 T2109 T2111 amod multiorgan,disease
R1818 T2010 T2012 nsubjpass cells,reported
R1819 T2110 T2111 amod inflammatory,disease
R1820 T2111 T2114 nmod disease,]
R1821 T2112 T2111 appos [,disease
R1822 T2011 T2012 auxpass were,reported
R1823 T2113 T2114 nummod 16,]
R1824 T2114 T2069 npadvmod ],demonstrated
R1825 T2115 T2069 punct .,demonstrated
R1826 T2116 T2130 mark Although,demonstrated
R1827 T2012 T2012 ROOT reported,reported
R1828 T2117 T2118 det the,effect
R1829 T2118 T2130 nsubjpass effect,demonstrated
R1830 T2119 T2118 prep of,effect
R1831 T2013 T2014 aux to,express
R1832 T2120 T2119 pobj TGF-β,of
R1833 T2121 T2118 prep on,effect
R1834 T2122 T2127 amod natural,induction
R1835 T2014 T2012 xcomp express,reported
R1836 T2123 T2122 cc and,natural
R1837 T2124 T2122 conj inducible,natural
R1838 T2015 T2018 nummod FOXP3,]
R1839 T2125 T2127 compound Treg,induction
R1840 T2126 T2127 compound cell,induction
R1841 T2127 T2121 pobj induction,on
R1842 T2128 T2130 aux has,demonstrated
R1843 T2129 T2130 auxpass been,demonstrated
R1844 T2130 T2139 advcl demonstrated,remain
R1845 T2016 T2018 nmod [,]
R1846 T2131 T2130 advmod repeatedly,demonstrated
R1847 T2132 T2134 compound [,]
R1848 T2133 T2134 compound "15,17",]
R1849 T2017 T2018 nummod 10,]
R1850 T2134 T2130 dobj ],demonstrated
R1851 T2135 T2139 punct ",",remain
R1852 T2136 T2138 poss its,mechanisms
R1853 T2018 T2014 dobj ],express
R1854 T2137 T2138 amod molecular,mechanisms
R1855 T2138 T2139 nsubj mechanisms,remain
R1856 T2019 T2012 punct .,reported
R1857 T2020 T2022 det The,mechanisms
R1858 T2021 T2022 amod exact,mechanisms
R1859 T2139 T2139 ROOT remain,remain
R1860 T2022 T2026 nsubj mechanisms,are
R1861 T2140 T2142 aux to,identified
R1862 T2141 T2142 auxpass be,identified
R1863 T2142 T2139 xcomp identified,remain
R1864 T2023 T2022 prep of,mechanisms
R1865 T2143 T2139 punct .,remain
R1866 T2144 T2146 det The,study
R1867 T2145 T2146 amod current,study
R1868 T2024 T2025 compound iTreg,generation
R1869 T2146 T2147 nsubj study,provides
R1870 T2147 T2147 ROOT provides,provides
R1871 T2025 T2023 pobj generation,of
R1872 T2148 T2147 dobj evidence,provides
R1873 T2149 T2153 mark that,play
R1874 T2150 T2153 nsubj GATA3,play
R1875 T2151 T2150 cc and,GATA3
R1876 T2026 T2026 ROOT are,are
R1877 T2152 T2150 conj FOXP3,GATA3
R1878 T2153 T2148 acl play,evidence
R1879 T2027 T2026 acomp unclear,are
R1880 T2154 T2156 det a,role
R1881 T2155 T2156 amod competitive,role
R1882 T2028 T2026 punct ",",are
R1883 T2156 T2153 dobj role,play
R1884 T2157 T2156 prep in,role
R1885 T2158 T2160 compound iTreg,commitment
R1886 T2029 T2026 cc but,are
R1887 T2159 T2160 compound cell,commitment
R1888 T2160 T2157 pobj commitment,in
R1889 T2161 T2160 prep as,commitment
R1890 T2162 T2161 pobj T-bet,as
R1891 T2163 T2162 cc and,T-bet
R1892 T2164 T2162 conj GATA3,T-bet
R1893 T2165 T2162 prep for,T-bet
R1894 T2166 T2165 pobj Th1,for
R1895 T2030 T2032 compound T,receptor
R1896 T2167 T2166 cc and,Th1
R1897 T2168 T2166 conj Th2,Th1
R1898 T2169 T2160 conj differentiation,commitment
R1899 T2031 T2032 compound cell,receptor
R1900 T2170 T2153 punct ",",play
R1901 T2171 T2153 advmod respectively,play
R1902 T2032 T2039 nsubjpass receptor,shown
R1903 T2172 T2147 punct .,provides
R1904 T2173 T2174 nsubj We,show
R1905 T2174 T2174 ROOT show,show
R1906 T2033 T2034 punct (,TCR
R1907 T2175 T2177 mark that,inhibits
R1908 T2176 T2177 nsubj GATA3,inhibits
R1909 T2177 T2174 ccomp inhibits,show
R1910 T2034 T2032 appos TCR,receptor
R1911 T2178 T2179 nummod FOXP3,induction
R1912 T2179 T2177 dobj induction,inhibits
R1913 T2180 T2177 cc and,inhibits
R1914 T2035 T2032 punct ),receptor
R1915 T2181 T2183 mark that,limits
R1916 T2036 T2039 nsubjpass triggering,shown
R1917 T2037 T2039 aux has,shown
R1918 T2182 T2183 nsubj IL-4,limits
R1919 T2183 T2177 conj limits,inhibits
R1920 T2038 T2039 auxpass been,shown
R1921 T2184 T2185 nummod FOXP3,expression
R1922 T2039 T2026 conj shown,are
R1923 T2040 T2041 aux to,induce
R1924 T2185 T2183 dobj expression,limits
R1925 T2041 T2039 xcomp induce,shown
R1927 T2186 T2183 prep in,limits
R1928 T2187 T2189 det a,way
R1929 T2188 T2189 amod GATA3-mediated,way
R1930 T2189 T2186 pobj way,in
R1931 T2190 T2183 punct ",",limits
R1932 T2191 T2192 preconj both,in
R1933 T2192 T2183 prep in,limits
R1934 T2193 T2192 pobj vitro,in
R1935 T2194 T2192 cc and,in
R1937 T2195 T2192 conj in,in
R1938 T2196 T2195 pobj vivo,in
R1940 T2197 T2174 punct .,show
R1941 T2198 T2200 nsubj We,show
R1942 T2199 T2200 advmod also,show
R1943 T2200 T2200 ROOT show,show
R1944 T2201 T2204 mark that,binds
R1945 T2202 T2204 nsubj GATA3,binds
R1946 T2203 T2204 advmod directly,binds
R1947 T2204 T2200 ccomp binds,show
R1949 T2205 T2204 prep to,binds
R1950 T2206 T2208 det the,promoter
R1951 T2207 T2208 nummod FOXP3,promoter
R1952 T2208 T2205 pobj promoter,to
R1953 T2209 T2204 cc and,binds
R1955 T2210 T2211 advmod thereby,prevents
R1956 T2211 T2204 conj prevents,binds
R1957 T2212 T2213 det the,induction
R1959 T2213 T2211 dobj induction,prevents
R1960 T2214 T2213 prep of,induction
R1961 T2215 T2216 det this,gene
R1962 T2216 T2214 pobj gene,of
R1964 T2217 T2200 punct ",",show
R1966 T2218 T2200 advcl demonstrating,show
R1967 T2219 T2222 mark that,overrules
R1969 T2220 T2221 amod Th2,differentiation
R1970 T2221 T2222 nsubj differentiation,overrules
R1971 T2222 T2218 ccomp overrules,demonstrating
R1972 T2223 T2224 compound iTreg,induction
R1973 T2224 T2222 dobj induction,overrules
R1975 T2225 T2200 punct .,show
R1410 T1670 T1673 nummod Th1,cells
R1411 T1671 T1670 cc or,Th1
R1412 T1672 T1670 conj Th2,Th1
R1413 T1673 T1669 pobj cells,as
R1414 T1674 T1673 punct ",",cells
R1415 T1675 T1676 nsubj which,are
R1416 T1676 T1673 relcl are,cells
R1417 T1677 T1678 advmod most,efficient
R1418 T1678 T1676 acomp efficient,are
R1419 T1679 T1676 prep in,are
R1420 T1680 T1679 pcomp defeating,in
R1421 T1681 T1684 amod microbial,invaders
R1422 T1682 T1681 cc or,microbial
R1423 T1683 T1681 conj parasitic,microbial
R1424 T1684 T1680 dobj invaders,defeating
R1425 T1685 T1680 advmod respectively,defeating
R1426 T1686 T1663 punct .,differentiate
R1427 T1687 T1688 det A,hallmark
R1428 T1688 T1695 nsubj hallmark,is
R1429 T1689 T1688 prep of,hallmark
R1430 T1690 T1694 nummod Th1,pathways
R1431 T1691 T1690 cc and,Th1
R1432 T1692 T1690 conj Th2,Th1
R1433 T1693 T1694 compound differentiation,pathways
R1434 T1694 T1689 pobj pathways,of
R1435 T1695 T1695 ROOT is,is
R1436 T1696 T1697 det the,exclusiveness
R1437 T1697 T1695 attr exclusiveness,is
R1438 T1698 T1697 prep of,exclusiveness
R1439 T1699 T1701 det the,phenotype
R1440 T1700 T1701 amod individual,phenotype
R1441 T1701 T1698 pobj phenotype,of
R1442 T1702 T1701 acl leading,phenotype
R1443 T1703 T1702 prep to,leading
R1444 T1704 T1705 det either,Th1
R1681 T1941 T1937 cc and,generated
R1682 T1942 T1943 auxpass are,assumed
R1683 T1943 T1937 conj assumed,generated
R1684 T1944 T1945 aux to,protect
R1685 T1945 T1943 xcomp protect,assumed
R1686 T1946 T1945 prep against,protect
R1687 T1947 T1948 det the,activity
R1688 T1948 T1946 pobj activity,against
R1689 T1949 T1948 prep of,activity
R1690 T1950 T1952 amod autoreactive,cells
R1691 T1951 T1952 compound T,cells
R1692 T1952 T1949 pobj cells,of
R1693 T1953 T1945 prep in,protect
R1694 T1954 T1955 det the,periphery
R1695 T1955 T1953 pobj periphery,in
R1696 T1956 T1937 punct .,generated
R1697 T1957 T1958 det These,cells
R1698 T1958 T1959 nsubj cells,express
R1699 T1959 T1959 ROOT express,express
R1700 T1960 T1963 det the,factor
R1701 T1961 T1963 compound forkhead,factor
R1702 T1962 T1963 compound transcription,factor
R1703 T1963 T1959 dobj factor,express
R1704 T1964 T1963 appos FOXP3,factor
R1705 T1965 T1964 cc and,FOXP3
R1706 T1966 T1967 advmod constitutively,express
R1707 T1967 T1959 conj express,express
R1708 T1968 T1967 dobj CD25,express
R1709 T1969 T1968 prep on,CD25
R1710 T1970 T1971 poss their,surface
R1711 T1971 T1969 pobj surface,on
R1712 T1972 T1967 punct ",",express
R1713 T1973 T1967 cc but,express
R1714 T1974 T1975 nsubj they,lack
R1715 T1975 T1967 conj lack,express
R1716 T1976 T1975 dobj expression,lack
R1717 T1977 T1976 prep of,expression

UBERON-AE

Id Subject Object Predicate Lexical cue
T918 1756-1762 http://purl.obolibrary.org/obo/UBERON_0002370 denotes thymus
T919 1811-1817 http://purl.obolibrary.org/obo/UBERON_0002370 denotes thymus

GO-BP

Id Subject Object Predicate Lexical cue
T995 23-39 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T996 114-130 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T997 1257-1272 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T998 63-78 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T999 107-130 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T1000 107-130 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune responses
T1001 107-130 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune responses
T1002 107-130 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune responses
T1003 107-130 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune responses
T1004 107-130 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune responses
T1005 191-210 http://purl.obolibrary.org/obo/GO_0030154 denotes cells differentiate
T1006 1069-1082 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1007 1941-1954 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1008 1184-1191 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T1009 2357-2360 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T1010 3046-3066 http://purl.obolibrary.org/obo/GO_0002360 denotes cell commitment as T

GO-MF

Id Subject Object Predicate Lexical cue
T2281 672-677 http://purl.obolibrary.org/obo/GO_0005136 denotes 4 (IL
T2282 877-881 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T2283 1341-1345 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T2284 3181-3185 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T2285 883-887 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T2286 892-897 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T2287 1334-1343 http://purl.obolibrary.org/obo/GO_0005138 denotes 6] and IL

GO-CC

Id Subject Object Predicate Lexical cue
T2290 1217-1221 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2291 2342-2346 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2292 2737-2741 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2293 2849-2853 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2294 3046-3050 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2295 1884-1906 http://purl.obolibrary.org/obo/GO_0005938 denotes cells in the periphery
T2296 1884-1906 http://purl.obolibrary.org/obo/GO_0071944 denotes cells in the periphery
T2297 2357-2360 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T2288 63-67 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2289 957-961 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

sentences

Id Subject Object Predicate Lexical cue
T975 13-161 Sentence denotes Effective immune responses are characterized by T cell activation, which directs adaptive and innate immune responses to kill pathogens efficiently.
T976 162-345 Sentence denotes Dependent on the pathogen, T cells differentiate into different subtypes, such as Th1 or Th2 cells, which are most efficient in defeating microbial or parasitic invaders respectively.
T977 346-505 Sentence denotes A hallmark of Th1 and Th2 differentiation pathways is the exclusiveness of the individual phenotype leading to either Th1 or Th2, but not to mixed populations.
T978 506-646 Sentence denotes The exclusiveness of this mechanism is provided by a polarization process, where Th2 differentiation inhibits Th1 commitment and vice versa.
T979 647-783 Sentence denotes Specifically interleukin 4 (IL-4)–induced STAT6 and GATA3 inhibit differentiation into Th1 cells in the early phase of commitment [1,2].
T980 784-983 Sentence denotes GATA3 is sufficient to induce a Th2 phenotype [3] and acts not only through the induction of IL-4, IL-5 and IL-13, the Th2 cytokines, but also through the inhibition of Th1 cell-specific factors [3].
T981 984-1238 Sentence denotes Recently, it was shown that T-bet directly modulates GATA3 function, suggesting that transcription factors compete in the early differentiation phase of T cells, potentially integrating environmental signals to finally imprint the T cell phenotype [4,5].
T982 1239-1414 Sentence denotes A GATA3-dominated immune response has been shown to be essential in airway hyperresonsiveness [6] and IL-4–dominated responses can break antigen-specific immune tolerance [7].
T983 1415-1594 Sentence denotes Overexpression of a dominant negative form of GATA3 [8] or treatment with antisense-mediated GATA3 blockade [9] decreased the severity of the allergic airway hyper-responsiveness.
T984 1595-1734 Sentence denotes The discovery of regulatory T (Treg) cells highlights another phenotype of T cells, which is essential for tolerance against self-antigens.
T985 1735-1907 Sentence denotes Naturally occurring, thymus-derived Treg (nTreg) cells are generated in the thymus and are assumed to protect against the activity of autoreactive T cells in the periphery.
T986 1908-2067 Sentence denotes These cells express the forkhead transcription factor FOXP3 and constitutively express CD25 on their surface, but they lack expression of Th1 or Th2 cytokines.
T987 2068-2211 Sentence denotes Particularly interesting are those Treg cells that are generated in the periphery and thus are potential targets for therapeutic interventions.
T988 2212-2281 Sentence denotes These induced Treg (iTreg) cells were reported to express FOXP3 [10].
T989 2282-2519 Sentence denotes The exact mechanisms of iTreg generation are unclear, but T cell receptor (TCR) triggering has been shown to induce FOXP3 expression and suppressive cells in human [11,12], however the phenotype appears to be of transient nature [13,14].
T990 2520-2789 Sentence denotes TGF-β has been demonstrated to be important for the persistent induction of these cells in vitro and in vivo, since animals lacking the TGF-βRII on T cells have fewer peripherally iTreg cells [15] and suffer from a T cell–dependent multiorgan inflammatory disease [16].
T991 2790-2955 Sentence denotes Although the effect of TGF-β on natural and inducible Treg cell induction has been demonstrated repeatedly [15,17], its molecular mechanisms remain to be identified.
T992 2956-3127 Sentence denotes The current study provides evidence that GATA3 and FOXP3 play a competitive role in iTreg cell commitment as T-bet and GATA3 for Th1 and Th2 differentiation, respectively.
T993 3128-3261 Sentence denotes We show that GATA3 inhibits FOXP3 induction and that IL-4 limits FOXP3 expression in a GATA3-mediated way, both in vitro and in vivo.
T994 3262-3437 Sentence denotes We also show that GATA3 directly binds to the FOXP3 promoter and thereby prevents the induction of this gene, demonstrating that Th2 differentiation overrules iTreg induction.
T21 0-12 Sentence denotes Introduction
T22 13-161 Sentence denotes Effective immune responses are characterized by T cell activation, which directs adaptive and innate immune responses to kill pathogens efficiently.
T23 162-345 Sentence denotes Dependent on the pathogen, T cells differentiate into different subtypes, such as Th1 or Th2 cells, which are most efficient in defeating microbial or parasitic invaders respectively.
T24 346-505 Sentence denotes A hallmark of Th1 and Th2 differentiation pathways is the exclusiveness of the individual phenotype leading to either Th1 or Th2, but not to mixed populations.
T25 506-646 Sentence denotes The exclusiveness of this mechanism is provided by a polarization process, where Th2 differentiation inhibits Th1 commitment and vice versa.
T26 647-783 Sentence denotes Specifically interleukin 4 (IL-4)–induced STAT6 and GATA3 inhibit differentiation into Th1 cells in the early phase of commitment [1,2].
T27 784-983 Sentence denotes GATA3 is sufficient to induce a Th2 phenotype [3] and acts not only through the induction of IL-4, IL-5 and IL-13, the Th2 cytokines, but also through the inhibition of Th1 cell-specific factors [3].
T28 984-1238 Sentence denotes Recently, it was shown that T-bet directly modulates GATA3 function, suggesting that transcription factors compete in the early differentiation phase of T cells, potentially integrating environmental signals to finally imprint the T cell phenotype [4,5].
T29 1239-1414 Sentence denotes A GATA3-dominated immune response has been shown to be essential in airway hyperresonsiveness [6] and IL-4–dominated responses can break antigen-specific immune tolerance [7].
T30 1415-1594 Sentence denotes Overexpression of a dominant negative form of GATA3 [8] or treatment with antisense-mediated GATA3 blockade [9] decreased the severity of the allergic airway hyper-responsiveness.
T31 1595-1734 Sentence denotes The discovery of regulatory T (Treg) cells highlights another phenotype of T cells, which is essential for tolerance against self-antigens.
T32 1735-1907 Sentence denotes Naturally occurring, thymus-derived Treg (nTreg) cells are generated in the thymus and are assumed to protect against the activity of autoreactive T cells in the periphery.
T33 1908-2067 Sentence denotes These cells express the forkhead transcription factor FOXP3 and constitutively express CD25 on their surface, but they lack expression of Th1 or Th2 cytokines.
T34 2068-2211 Sentence denotes Particularly interesting are those Treg cells that are generated in the periphery and thus are potential targets for therapeutic interventions.
T35 2212-2281 Sentence denotes These induced Treg (iTreg) cells were reported to express FOXP3 [10].
T36 2282-2519 Sentence denotes The exact mechanisms of iTreg generation are unclear, but T cell receptor (TCR) triggering has been shown to induce FOXP3 expression and suppressive cells in human [11,12], however the phenotype appears to be of transient nature [13,14].
T37 2520-2789 Sentence denotes TGF-β has been demonstrated to be important for the persistent induction of these cells in vitro and in vivo, since animals lacking the TGF-βRII on T cells have fewer peripherally iTreg cells [15] and suffer from a T cell–dependent multiorgan inflammatory disease [16].
T38 2790-2955 Sentence denotes Although the effect of TGF-β on natural and inducible Treg cell induction has been demonstrated repeatedly [15,17], its molecular mechanisms remain to be identified.
T39 2956-3127 Sentence denotes The current study provides evidence that GATA3 and FOXP3 play a competitive role in iTreg cell commitment as T-bet and GATA3 for Th1 and Th2 differentiation, respectively.
T40 3128-3261 Sentence denotes We show that GATA3 inhibits FOXP3 induction and that IL-4 limits FOXP3 expression in a GATA3-mediated way, both in vitro and in vivo.
T41 3262-3437 Sentence denotes We also show that GATA3 directly binds to the FOXP3 promoter and thereby prevents the induction of this gene, demonstrating that Th2 differentiation overrules iTreg induction.

events-check-again

Id Subject Object Predicate Lexical cue
T2517 660-673 Protein denotes interleukin 4
T2518 675-679 Protein denotes IL-4
T2519 681-688 Positive_regulation denotes induced
T2520 681-688 Positive_regulation denotes induced
T2521 689-694 Protein denotes STAT6
T2522 699-704 Protein denotes GATA3
T2523 784-789 Protein denotes GATA3
T2524 864-873 Positive_regulation denotes induction
T2525 864-873 Positive_regulation denotes induction
T2526 864-873 Positive_regulation denotes induction
T2527 877-881 Protein denotes IL-4
T2528 883-887 Protein denotes IL-5
T2529 892-897 Protein denotes IL-13
T2530 1012-1017 Protein denotes T-bet
T2531 1027-1036 Regulation denotes modulates
T2532 1037-1042 Protein denotes GATA3
T2533 1241-1246 Protein denotes GATA3
T2534 1341-1345 Protein denotes IL-4
T2535 1415-1457 Negative_regulation denotes Overexpression of a dominant negative form
T2536 1461-1466 Protein denotes GATA3
T2537 1508-1513 Protein denotes GATA3
T2538 1514-1522 Negative_regulation denotes blockade
T2539 1920-1927 Gene_expression denotes express
T2540 1962-1967 Protein denotes FOXP3
T2541 1987-1994 Gene_expression denotes express
T2542 1995-1999 Protein denotes CD25
T2543 2262-2269 Gene_expression denotes express
T2544 2270-2275 Protein denotes FOXP3
T2545 2391-2397 Positive_regulation denotes induce
T2546 2398-2403 Protein denotes FOXP3
T2547 2404-2414 Gene_expression denotes expression
T2548 2520-2525 Protein denotes TGF-β
T2549 2644-2651 Negative_regulation denotes lacking
T2550 2656-2664 Protein denotes TGF-βRII
T2551 2813-2818 Protein denotes TGF-β
T2552 2997-3002 Protein denotes GATA3
T2553 3007-3012 Protein denotes FOXP3
T2554 3065-3070 Protein denotes T-bet
T2555 3075-3080 Protein denotes GATA3
T2556 3141-3146 Protein denotes GATA3
T2557 3147-3155 Negative_regulation denotes inhibits
T2558 3156-3161 Protein denotes FOXP3
T2559 3162-3171 Positive_regulation denotes induction
T2560 3181-3185 Protein denotes IL-4
T2561 3186-3192 Negative_regulation denotes limits
T2562 3193-3198 Protein denotes FOXP3
T2563 3199-3209 Gene_expression denotes expression
T2564 3215-3220 Protein denotes GATA3
T2565 3221-3233 Positive_regulation denotes mediated way
T2566 3280-3285 Protein denotes GATA3
T2567 3295-3300 Binding denotes binds
T2568 3308-3313 Protein denotes FOXP3
T2569 3314-3322 Entity denotes promoter
T2570 3335-3343 Negative_regulation denotes prevents
T2571 3348-3357 Positive_regulation denotes induction
R2114 T2517 T2519 causeOf interleukin 4,induced
R2115 T2517 T2520 causeOf interleukin 4,induced
R2116 T2518 T2517 equivalentTo IL-4,interleukin 4
R2118 T2521 T2519 themeOf STAT6,induced
R2119 T2522 T2520 themeOf GATA3,induced
R2121 T2523 T2524 causeOf GATA3,induction
R2122 T2523 T2526 causeOf GATA3,induction
R2123 T2523 T2525 causeOf GATA3,induction
R2125 T2527 T2525 themeOf IL-4,induction
R2126 T2528 T2524 themeOf IL-5,induction
R2127 T2529 T2526 themeOf IL-13,induction
R2129 T2530 T2531 causeOf T-bet,modulates
R2130 T2532 T2531 themeOf GATA3,modulates
R2131 T2536 T2535 themeOf GATA3,Overexpression of a dominant negative form
R2132 T2537 T2538 themeOf GATA3,blockade
R2134 T2540 T2539 themeOf FOXP3,express
R2136 T2542 T2541 themeOf CD25,express
R2137 T2544 T2543 themeOf FOXP3,express
R2141 T2546 T2547 themeOf FOXP3,expression
R2143 T2547 T2545 themeOf expression,induce
R2145 T2550 T2549 themeOf TGF-βRII,lacking
R2147 T2556 T2557 causeOf GATA3,inhibits
R2148 T2558 T2559 themeOf FOXP3,induction
R2149 T2559 T2557 themeOf induction,inhibits
R2151 T2560 T2561 causeOf IL-4,limits
R2152 T2561 T2565 themeOf limits,mediated way
R2153 T2562 T2563 themeOf FOXP3,expression
R2155 T2563 T2561 themeOf expression,limits
R2156 T2564 T2565 causeOf GATA3,mediated way
R2158 T2566 T2567 themeOf GATA3,binds
R2159 T2567 T2570 causeOf binds,prevents
R2161 T2568 T2571 themeOf FOXP3,induction
R2162 T2569 T2567 themeOf promoter,binds
R2163 T2569 T2568 partOf promoter,FOXP3
R2165 T2571 T2570 themeOf induction,prevents

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T2298 360-363 Protein denotes Th1
T2299 368-371 Protein denotes Th2
T2300 587-590 Protein denotes Th2
T2301 660-673 Protein denotes interleukin 4
T2302 675-679 Protein denotes IL-4
T2303 689-694 Protein denotes STAT6
T2304 699-704 Protein denotes GATA3
T2305 680-688 Positive_regulation denotes –induced
T2306 680-688 Positive_regulation denotes –induced
T2307 680-688 Positive_regulation denotes –induced
T2308 680-688 Positive_regulation denotes –induced
T2309 784-789 Protein denotes GATA3
T2310 877-881 Protein denotes IL-4
T2311 883-887 Protein denotes IL-5
T2312 892-897 Protein denotes IL-13
T2313 953-956 Protein denotes Th1
T2314 864-873 Positive_regulation denotes induction
T2315 864-873 Positive_regulation denotes induction
T2316 864-873 Positive_regulation denotes induction
T2317 939-949 Negative_regulation denotes inhibition
T2318 1037-1042 Protein denotes GATA3
T2319 1027-1036 Regulation denotes modulates
T2320 1241-1246 Protein denotes GATA3
T2321 1461-1466 Protein denotes GATA3
T2322 1508-1513 Protein denotes GATA3
T2323 1514-1522 Negative_regulation denotes blockade
T2324 1932-1967 Protein denotes forkhead transcription factor FOXP3
T2325 1995-1999 Protein denotes CD25
T2326 2046-2049 Protein denotes Th1
T2327 2053-2066 Protein denotes Th2 cytokines
T2328 1920-1927 Gene_expression denotes express
T2329 1987-1994 Gene_expression denotes express
T2330 2032-2042 Gene_expression denotes expression
T2331 2032-2042 Gene_expression denotes expression
T2332 2027-2031 Negative_regulation denotes lack
T2333 2027-2031 Negative_regulation denotes lack
T2334 2270-2275 Protein denotes FOXP3
T2335 2262-2269 Gene_expression denotes express
T2336 2340-2355 Protein denotes T cell receptor
T2337 2357-2360 Protein denotes TCR
T2338 2398-2403 Protein denotes FOXP3
T2339 2404-2414 Gene_expression denotes expression
T2340 2391-2397 Positive_regulation denotes induce
T2341 2520-2525 Protein denotes TGF-β
T2342 2656-2664 Protein denotes TGF-βRII
T2343 2644-2651 Negative_regulation denotes lacking
T2344 2813-2818 Protein denotes TGF-β
T2345 2997-3002 Protein denotes GATA3
T2346 3007-3012 Protein denotes FOXP3
T2347 3075-3080 Protein denotes GATA3
T2348 3085-3088 Protein denotes Th1
T2349 3141-3146 Protein denotes GATA3
T2350 3156-3161 Protein denotes FOXP3
T2351 3193-3198 Protein denotes FOXP3
T2352 3215-3220 Protein denotes GATA3
T2353 3162-3171 Positive_regulation denotes induction
T2354 3199-3209 Gene_expression denotes expression
T2355 3147-3155 Negative_regulation denotes inhibits
T2356 3186-3192 Negative_regulation denotes limits
T2357 3280-3285 Protein denotes GATA3
T2358 3308-3322 Protein denotes FOXP3 promoter
T2359 3295-3300 Binding denotes binds
R1995 T2301 T2305 causeOf interleukin 4,–induced
R1996 T2301 T2306 causeOf interleukin 4,–induced
R1998 T2302 T2307 causeOf IL-4,–induced
R1999 T2302 T2308 causeOf IL-4,–induced
R2000 T2303 T2305 themeOf STAT6,–induced
R2001 T2303 T2307 themeOf STAT6,–induced
R2002 T2304 T2306 themeOf GATA3,–induced
R2003 T2304 T2308 themeOf GATA3,–induced
R2005 T2309 T2314 causeOf GATA3,induction
R2006 T2309 T2315 causeOf GATA3,induction
R2007 T2309 T2316 causeOf GATA3,induction
R2008 T2309 T2317 causeOf GATA3,inhibition
R2009 T2310 T2314 themeOf IL-4,induction
R2011 T2311 T2315 themeOf IL-5,induction
R2012 T2312 T2316 themeOf IL-13,induction
R2013 T2313 T2317 themeOf Th1,inhibition
R2017 T2318 T2319 themeOf GATA3,modulates
R2019 T2322 T2323 themeOf GATA3,blockade
R2020 T2324 T2328 themeOf forkhead transcription factor FOXP3,express
R2021 T2325 T2329 themeOf CD25,express
R2022 T2326 T2330 themeOf Th1,expression
R2023 T2327 T2331 themeOf Th2 cytokines,expression
R2025 T2330 T2332 themeOf expression,lack
R2026 T2331 T2333 themeOf expression,lack
R2028 T2334 T2335 themeOf FOXP3,express
R2030 T2338 T2339 themeOf FOXP3,expression
R2033 T2339 T2340 themeOf expression,induce
R2035 T2342 T2343 themeOf TGF-βRII,lacking
R2038 T2349 T2355 causeOf GATA3,inhibits
R2040 T2350 T2353 themeOf FOXP3,induction
R2041 T2351 T2354 themeOf FOXP3,expression
R2042 T2353 T2355 themeOf induction,inhibits
R2043 T2354 T2356 themeOf expression,limits
R2045 T2357 T2359 themeOf GATA3,binds
R2046 T2358 T2359 themeOf FOXP3 promoter,binds

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue
T947 2270-2275 Protein denotes FOXP3
T948 2391-2397 Positive_regulation denotes induce
T949 2398-2403 Protein denotes FOXP3
T950 2404-2414 Gene_expression denotes expression
T951 2520-2525 Protein denotes TGF-β
T952 2644-2651 Negative_regulation denotes lacking
T953 2656-2664 Protein denotes TGF-βRII
T954 2813-2818 Protein denotes TGF-β
T955 2997-3002 Protein denotes GATA3
T956 3007-3012 Protein denotes FOXP3
T957 3065-3070 Protein denotes T-bet
T958 3075-3080 Protein denotes GATA3
T959 3141-3146 Protein denotes GATA3
T960 3147-3155 Negative_regulation denotes inhibits
T961 3156-3161 Protein denotes FOXP3
T962 3162-3171 Positive_regulation denotes induction
T971 3308-3313 Protein denotes FOXP3
T972 3314-3322 Entity denotes promoter
T973 3335-3343 Negative_regulation denotes prevents
T974 3348-3357 Positive_regulation denotes induction
T920 660-673 Protein denotes interleukin 4
T921 675-679 Protein denotes IL-4
T922 681-688 Positive_regulation denotes induced
T923 681-688 Positive_regulation denotes induced
T924 689-694 Protein denotes STAT6
T925 699-704 Protein denotes GATA3
T926 784-789 Protein denotes GATA3
T927 864-873 Positive_regulation denotes induction
T928 864-873 Positive_regulation denotes induction
T929 864-873 Positive_regulation denotes induction
T930 877-881 Protein denotes IL-4
T931 883-887 Protein denotes IL-5
T932 892-897 Protein denotes IL-13
T933 1012-1017 Protein denotes T-bet
T934 1027-1036 Regulation denotes modulates
T935 1037-1042 Protein denotes GATA3
T936 1241-1246 Protein denotes GATA3
T937 1341-1345 Protein denotes IL-4
T938 1415-1457 Negative_regulation denotes Overexpression of a dominant negative form
T939 1461-1466 Protein denotes GATA3
T940 1508-1513 Protein denotes GATA3
T941 1514-1522 Negative_regulation denotes blockade
T942 1920-1927 Gene_expression denotes express
T943 1962-1967 Protein denotes FOXP3
T944 1987-1994 Gene_expression denotes express
T945 1995-1999 Protein denotes CD25
T946 2262-2269 Gene_expression denotes express
T963 3181-3185 Protein denotes IL-4
T964 3186-3192 Negative_regulation denotes limits
T965 3193-3198 Protein denotes FOXP3
T966 3199-3209 Gene_expression denotes expression
T967 3215-3220 Protein denotes GATA3
T968 3221-3233 Positive_regulation denotes mediated way
T969 3280-3285 Protein denotes GATA3
T970 3295-3300 Binding denotes binds
R740 T926 T927 causeOf GATA3,induction
R741 T926 T929 causeOf GATA3,induction
R742 T926 T928 causeOf GATA3,induction
R743 T930 T928 themeOf IL-4,induction
R744 T931 T927 themeOf IL-5,induction
R745 T932 T929 themeOf IL-13,induction
R746 T933 T934 causeOf T-bet,modulates
R747 T935 T934 themeOf GATA3,modulates
R748 T939 T938 themeOf GATA3,Overexpression of a dominant negative form
R749 T940 T941 themeOf GATA3,blockade
R750 T943 T942 themeOf FOXP3,express
R751 T945 T944 themeOf CD25,express
R752 T947 T946 themeOf FOXP3,express
R753 T949 T950 themeOf FOXP3,expression
R754 T950 T948 themeOf expression,induce
R755 T953 T952 themeOf TGF-βRII,lacking
R756 T959 T960 causeOf GATA3,inhibits
R757 T961 T962 themeOf FOXP3,induction
R758 T962 T960 themeOf induction,inhibits
R759 T963 T964 causeOf IL-4,limits
R760 T964 T968 themeOf limits,mediated way
R761 T965 T966 themeOf FOXP3,expression
R762 T966 T964 themeOf expression,limits
R763 T967 T968 causeOf GATA3,mediated way
R764 T969 T970 themeOf GATA3,binds
R765 T970 T973 causeOf binds,prevents
R766 T971 T974 themeOf FOXP3,induction
R767 T972 T970 themeOf promoter,binds
R768 T972 T971 partOf promoter,FOXP3
R769 T974 T973 themeOf induction,prevents
R735 T920 T922 causeOf interleukin 4,induced
R736 T920 T923 causeOf interleukin 4,induced
R737 T921 T920 equivalentTo IL-4,interleukin 4
R738 T924 T922 themeOf STAT6,induced
R739 T925 T923 themeOf GATA3,induced

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T1583 660-673 P05112 denotes interleukin 4
T1584 675-679 P05112 denotes IL-4
T1585 689-694 P42226 denotes STAT6
T1586 699-704 P23771 denotes GATA3
T1587 784-789 P23771 denotes GATA3
T1588 877-881 P05112 denotes IL-4
T1589 883-887 P05113 denotes IL-5
T1590 892-897 P35225 denotes IL-13
T1591 1012-1017 Q9UL17 denotes T-bet
T1592 1037-1042 P23771 denotes GATA3
T1593 1241-1246 P23771 denotes GATA3
T1594 1341-1345 P05112 denotes IL-4
T1595 1461-1466 P23771 denotes GATA3
T1596 1508-1513 P23771 denotes GATA3
T1597 1962-1967 Q9BZS1 denotes FOXP3
T1598 1995-1999 P01589 denotes CD25
T1599 2270-2275 Q9BZS1 denotes FOXP3
T1600 2398-2403 Q9BZS1 denotes FOXP3
T1601 2520-2525 P01137 denotes TGF-β
T1602 2813-2818 P01137 denotes TGF-β
T1603 2997-3002 P23771 denotes GATA3
T1604 3007-3012 Q9BZS1 denotes FOXP3
T1605 3065-3070 Q9UL17 denotes T-bet
T1606 3075-3080 P23771 denotes GATA3
T1607 3141-3146 P23771 denotes GATA3
T1608 3156-3161 Q9BZS1 denotes FOXP3
T1609 3181-3185 P05112 denotes IL-4
T1610 3193-3198 Q9BZS1 denotes FOXP3
T1611 3215-3220 P23771 denotes GATA3
T1612 3280-3285 P23771 denotes GATA3
T1613 3308-3313 Q9BZS1 denotes FOXP3

test2

Id Subject Object Predicate Lexical cue
T867 660-673 Protein denotes interleukin 4
T868 675-679 Protein denotes IL-4
T869 681-688 Positive_regulation denotes induced
T870 689-694 Protein denotes STAT6
T871 699-704 Protein denotes GATA3
T872 784-789 Protein denotes GATA3
T873 864-873 Positive_regulation denotes induction
T874 877-881 Protein denotes IL-4
T875 883-887 Protein denotes IL-5
T876 892-897 Protein denotes IL-13
T877 1012-1017 Protein denotes T-bet
T878 1027-1036 Positive_regulation denotes modulates
T879 1037-1042 Protein denotes GATA3
T880 1241-1246 Protein denotes GATA3
T881 1341-1345 Protein denotes IL-4
T882 1415-1429 Positive_regulation denotes Overexpression
T883 1435-1443 Negative_regulation denotes dominant
T884 1461-1466 Protein denotes GATA3
T885 1499-1507 Positive_regulation denotes mediated
T886 1508-1513 Protein denotes GATA3
T887 1514-1522 Negative_regulation denotes blockade
T888 1920-1927 Gene_expression denotes express
T889 1962-1967 Protein denotes FOXP3
T890 1987-1994 Gene_expression denotes express
T891 1995-1999 Protein denotes CD25
T892 2262-2269 Gene_expression denotes express
T893 2270-2275 Protein denotes FOXP3
T894 2391-2397 Positive_regulation denotes induce
T895 2398-2403 Protein denotes FOXP3
T896 2404-2414 Gene_expression denotes expression
T897 2520-2525 Protein denotes TGF-β
T898 2644-2651 Negative_regulation denotes lacking
T899 2656-2664 Protein denotes TGF-βRII
T900 2813-2818 Protein denotes TGF-β
T901 2997-3002 Protein denotes GATA3
T902 3007-3012 Protein denotes FOXP3
T903 3065-3070 Protein denotes T-bet
T904 3075-3080 Protein denotes GATA3
T905 3141-3146 Protein denotes GATA3
T906 3147-3155 Negative_regulation denotes inhibits
T907 3156-3161 Protein denotes FOXP3
T908 3162-3171 Positive_regulation denotes induction
T909 3181-3185 Protein denotes IL-4
T910 3193-3198 Protein denotes FOXP3
T911 3199-3209 Gene_expression denotes expression
T912 3215-3220 Protein denotes GATA3
T913 3221-3229 Positive_regulation denotes mediated
T914 3280-3285 Protein denotes GATA3
T915 3295-3300 Binding denotes binds
T916 3308-3313 Protein denotes FOXP3
T917 3314-3322 Entity denotes promoter
R711 T867 T869 causeOf interleukin 4,induced
R712 T868 T867 equivalentTo IL-4,interleukin 4
R713 T870 T869 themeOf STAT6,induced
R714 T871 T869 themeOf GATA3,induced
R715 T874 T873 themeOf IL-4,induction
R716 T875 T873 themeOf IL-5,induction
R717 T876 T873 themeOf IL-13,induction
R718 T877 T878 causeOf T-bet,modulates
R719 T879 T878 themeOf GATA3,modulates
R720 T886 T887 themeOf GATA3,blockade
R721 T887 T885 themeOf blockade,mediated
R722 T889 T888 themeOf FOXP3,express
R723 T891 T890 themeOf CD25,express
R724 T893 T892 themeOf FOXP3,express
R725 T895 T896 themeOf FOXP3,expression
R726 T896 T894 themeOf expression,induce
R727 T899 T898 themeOf TGF-βRII,lacking
R728 T905 T906 causeOf GATA3,inhibits
R729 T907 T908 themeOf FOXP3,induction
R730 T908 T906 themeOf induction,inhibits
R731 T910 T911 themeOf FOXP3,expression
R732 T914 T915 themeOf GATA3,binds
R733 T917 T916 partOf promoter,FOXP3
R734 T917 T915 themeOf promoter,binds