PMC:2222968 / 2546-2835 JSONTXT

{"project":"sentences","denotations":[{"id":"T18","span":{"begin":0,"end":73},"obj":"Sentence"},{"id":"T19","span":{"begin":74,"end":176},"obj":"Sentence"},{"id":"T20","span":{"begin":177,"end":288},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"It is shown that Th2 responses prevent the generation of inducible Tregs. This is mediated by IL-4 induction of GATA3, which binds directly to and represses the FOXP3 promoter. This mechanism is likely to be relevant in the induction of immunotolerance, particularly in allergic diseases.\n"}