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{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T26162","span":{"begin":10,"end":14},"obj":"Protein"},{"id":"T26163","span":{"begin":24,"end":55},"obj":"Protein"},{"id":"T26164","span":{"begin":15,"end":23},"obj":"Negative_regulation"},{"id":"T26165","span":{"begin":69,"end":72},"obj":"Protein"},{"id":"T26166","span":{"begin":73,"end":79},"obj":"Protein"},{"id":"T26167","span":{"begin":124,"end":127},"obj":"Protein"},{"id":"T26168","span":{"begin":128,"end":132},"obj":"Protein"},{"id":"T26169","span":{"begin":134,"end":139},"obj":"Protein"},{"id":"T26170","span":{"begin":145,"end":149},"obj":"Protein"},{"id":"T26171","span":{"begin":446,"end":451},"obj":"Protein"},{"id":"T26172","span":{"begin":456,"end":461},"obj":"Protein"},{"id":"T26173","span":{"begin":513,"end":516},"obj":"Protein"},{"id":"T26174","span":{"begin":517,"end":523},"obj":"Protein"},{"id":"T26175","span":{"begin":549,"end":553},"obj":"Protein"},{"id":"T26176","span":{"begin":558,"end":563},"obj":"Protein"},{"id":"T26177","span":{"begin":462,"end":470},"obj":"Gene_expression"},{"id":"T26178","span":{"begin":462,"end":470},"obj":"Gene_expression"}],"relations":[{"id":"R19423","pred":"causeOf","subj":"T26162","obj":"T26164"},{"id":"R19424","pred":"themeOf","subj":"T26163","obj":"T26164"},{"id":"R19425","pred":"themeOf","subj":"T26171","obj":"T26177"},{"id":"R19426","pred":"themeOf","subj":"T26172","obj":"T26178"}],"text":"Figure 6 IL-4 Inhibits TGF-β–Mediated iTreg Commitment\nCFSE-labeled CD4+CD45RA+ cells were activated with plate-bound anti-CD3/CD28, TGF-β, and IL-4, as indicated. After 5 d, cells were analyzed by flow cytometry (A) and results of six independent experiments are shown in the bar graph below (B). Statistical significance (one-way Anova, Newman-Keuls) is indicated by asterisks (**p ≤ 0.01, ***p ≤ 0.001). (C) Kinetic analysis of intracellular GATA3 and FOXP3 staining is shown in panel C following exposure of CD4+CD45RA+ T cells to anti-CD3/28, IL-4 and TGF-β. Data are representative of three independent experiments. "}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T25862","span":{"begin":462,"end":470},"obj":"Gene_expression"},{"id":"T25863","span":{"begin":462,"end":470},"obj":"Gene_expression"},{"id":"T25864","span":{"begin":10,"end":14},"obj":"Protein"},{"id":"T25865","span":{"begin":456,"end":461},"obj":"Protein"},{"id":"T25866","span":{"begin":513,"end":516},"obj":"Protein"},{"id":"T25867","span":{"begin":517,"end":523},"obj":"Protein"},{"id":"T25868","span":{"begin":541,"end":544},"obj":"Protein"},{"id":"T25869","span":{"begin":545,"end":547},"obj":"Protein"},{"id":"T25870","span":{"begin":549,"end":553},"obj":"Protein"},{"id":"T25871","span":{"begin":558,"end":563},"obj":"Protein"},{"id":"T25872","span":{"begin":69,"end":72},"obj":"Protein"},{"id":"T25873","span":{"begin":73,"end":79},"obj":"Protein"},{"id":"T25874","span":{"begin":124,"end":127},"obj":"Protein"},{"id":"T25875","span":{"begin":128,"end":132},"obj":"Protein"},{"id":"T25876","span":{"begin":134,"end":139},"obj":"Protein"},{"id":"T25877","span":{"begin":145,"end":149},"obj":"Protein"},{"id":"T25878","span":{"begin":446,"end":451},"obj":"Protein"},{"id":"T25879","span":{"begin":24,"end":29},"obj":"Protein"}],"relations":[{"id":"R19187","pred":"themeOf","subj":"T25865","obj":"T25863"},{"id":"R19188","pred":"themeOf","subj":"T25878","obj":"T25862"}],"attributes":[{"id":"M587","pred":"Speculation","subj":"T25862","obj":"true"},{"id":"M588","pred":"Speculation","subj":"T25863","obj":"true"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Figure 6 IL-4 Inhibits TGF-β–Mediated iTreg Commitment\nCFSE-labeled CD4+CD45RA+ cells were activated with plate-bound anti-CD3/CD28, TGF-β, and IL-4, as indicated. After 5 d, cells were analyzed by flow cytometry (A) and results of six independent experiments are shown in the bar graph below (B). Statistical significance (one-way Anova, Newman-Keuls) is indicated by asterisks (**p ≤ 0.01, ***p ≤ 0.001). (C) Kinetic analysis of intracellular GATA3 and FOXP3 staining is shown in panel C following exposure of CD4+CD45RA+ T cells to anti-CD3/28, IL-4 and TGF-β. Data are representative of three independent experiments. "}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T25986","span":{"begin":10,"end":14},"obj":"P05112"},{"id":"T25987","span":{"begin":24,"end":29},"obj":"P01137"},{"id":"T25988","span":{"begin":69,"end":72},"obj":"P01730"},{"id":"T25989","span":{"begin":73,"end":79},"obj":"P08575"},{"id":"T25990","span":{"begin":124,"end":127},"obj":"P09693"},{"id":"T25991","span":{"begin":124,"end":127},"obj":"P20963"},{"id":"T25992","span":{"begin":124,"end":127},"obj":"P07766"},{"id":"T25993","span":{"begin":124,"end":127},"obj":"P04234"},{"id":"T25994","span":{"begin":128,"end":132},"obj":"P10747"},{"id":"T25995","span":{"begin":134,"end":139},"obj":"P01137"},{"id":"T25996","span":{"begin":145,"end":149},"obj":"P05112"},{"id":"T25997","span":{"begin":446,"end":451},"obj":"P23771"},{"id":"T25998","span":{"begin":456,"end":461},"obj":"Q9BZS1"},{"id":"T25999","span":{"begin":513,"end":516},"obj":"P01730"},{"id":"T26000","span":{"begin":517,"end":523},"obj":"P08575"},{"id":"T26001","span":{"begin":541,"end":544},"obj":"P07766"},{"id":"T26002","span":{"begin":541,"end":544},"obj":"P20963"},{"id":"T26003","span":{"begin":541,"end":544},"obj":"P04234"},{"id":"T26004","span":{"begin":541,"end":544},"obj":"P09693"},{"id":"T26005","span":{"begin":549,"end":553},"obj":"P05112"},{"id":"T26006","span":{"begin":558,"end":563},"obj":"P01137"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Figure 6 IL-4 Inhibits TGF-β–Mediated iTreg Commitment\nCFSE-labeled CD4+CD45RA+ cells were activated with plate-bound anti-CD3/CD28, TGF-β, and IL-4, as indicated. After 5 d, cells were analyzed by flow cytometry (A) and results of six independent experiments are shown in the bar graph below (B). Statistical significance (one-way Anova, Newman-Keuls) is indicated by asterisks (**p ≤ 0.01, ***p ≤ 0.001). (C) Kinetic analysis of intracellular GATA3 and FOXP3 staining is shown in panel C following exposure of CD4+CD45RA+ T cells to anti-CD3/28, IL-4 and TGF-β. Data are representative of three independent experiments. "}

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