PMC:2222968 / 17545-20240 JSON TXT

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2_test

Id	Subject	Object	Predicate	Lexical cue
18162042-11483607-84705019	2025-2027	11483607	denotes	20
T41406	2025-2027	11483607	denotes	20

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T8352	0-3	DT	denotes	The
T8353	4-8	NN	denotes	Role
T8354	9-11	IN	denotes	of
T8355	12-17	NN	denotes	TGF-β
T8356	18-20	IN	denotes	in
T8357	21-22	NN	denotes	T
T8358	23-27	NN	denotes	Cell
T8359	28-43	NN	denotes	Differentiation
T8360	44-52	IN	denotes	Although
T8361	53-66	JJ	denotes	TGF-β–reduced
T8362	67-71	NN	denotes	CD25
T8363	71-72	-COMMA-	denotes	,
T8364	73-77	NN	denotes	IL-4
T8365	78-88	NN	denotes	expression
T8366	88-89	-COMMA-	denotes	,
T8367	90-93	CC	denotes	and
T8368	94-98	NN	denotes	CD25
T8369	99-109	NN	denotes	expression
T8370	110-111	-LRB-	denotes	(
T8371	111-117	NN	denotes	Figure
T8372	118-120	NN	denotes	6B
T8373	120-121	-RRB-	denotes	)
T8374	121-122	-COMMA-	denotes	,
T8375	123-127	NN	denotes	IL-4
T8376	128-141	RB	denotes	significantly
T8377	142-151	VB	denotes	inhibited
T8378	152-166	JJ	denotes	TGF-β–mediated
T8379	167-176	NN	denotes	induction
T8380	177-179	IN	denotes	of
T8381	180-185	NN	denotes	FOXP3
T8382	186-188	IN	denotes	in
T8383	189-194	JJ	denotes	naive
T8384	195-196	NN	denotes	T
T8385	197-202	NN	denotes	cells
T8386	203-209	VB	denotes	driven
T8387	210-216	IN	denotes	toward
T8388	217-223	JJ	denotes	FOXP3+
T8389	224-225	NN	denotes	T
T8390	226-231	NN	denotes	cells
T8391	231-232	-COMMA-	denotes	,
T8392	233-235	IN	denotes	as
T8393	236-241	VB	denotes	shown
T8394	242-244	IN	denotes	by
T8395	245-249	NN	denotes	FACS
T8396	250-258	NN	denotes	analysis
T8397	259-260	-LRB-	denotes	(
T8398	260-266	NN	denotes	Figure
T8399	267-269	NN	denotes	6A
T8400	269-270	-RRB-	denotes	)
T8401	272-274	PRP	denotes	It
T8402	275-277	VB	denotes	is
T8403	278-283	VB	denotes	known
T8404	284-288	IN	denotes	that
T8405	289-293	NN	denotes	IL-4
T8406	294-296	VB	denotes	is
T8407	297-298	DT	denotes	a
T8408	299-305	JJ	denotes	potent
T8409	306-312	NN	denotes	growth
T8410	313-319	NN	denotes	factor
T8411	320-323	CC	denotes	and
T8412	324-327	MD	denotes	may
T8413	328-337	RB	denotes	therefore
T8414	338-343	VB	denotes	favor
T8415	344-347	DT	denotes	the
T8416	348-361	NN	denotes	proliferation
T8417	362-364	IN	denotes	of
T8418	365-371	NN	denotes	FOXP3–
T8419	372-377	NN	denotes	cells
T8420	378-381	CC	denotes	and
T8421	382-386	RB	denotes	thus
T8422	387-395	VB	denotes	decrease
T8423	396-399	DT	denotes	the
T8424	400-408	JJ	denotes	relative
T8425	409-419	NN	denotes	percentage
T8426	420-422	IN	denotes	of
T8427	423-429	JJ	denotes	FOXP3+
T8428	430-435	NN	denotes	cells
T8429	437-444	RB	denotes	However
T8430	444-445	-COMMA-	denotes	,
T8431	446-454	NN	denotes	analysis
T8432	455-457	IN	denotes	of
T8433	458-462	NN	denotes	cell
T8434	463-471	NN	denotes	division
T8435	472-480	NN	denotes	kinetics
T8436	481-483	IN	denotes	by
T8437	484-497	NN	denotes	CFSE-labeling
T8438	498-510	VB	denotes	demonstrated
T8439	511-515	IN	denotes	that
T8440	516-520	NN	denotes	IL-4
T8441	521-524	VB	denotes	did
T8442	525-528	RB	denotes	not
T8443	529-543	RB	denotes	differentially
T8444	544-551	VB	denotes	promote
T8445	552-556	NN	denotes	cell
T8446	557-563	NN	denotes	growth
T8447	564-566	IN	denotes	of
T8448	567-573	NN	denotes	FOXP3+
T8449	574-578	IN	denotes	over
T8450	579-583	DT	denotes	that
T8451	584-586	IN	denotes	of
T8452	587-593	NN	denotes	FOXP3–
T8453	595-597	IN	denotes	In
T8454	598-602	NN	denotes	fact
T8455	603-607	DT	denotes	both
T8456	608-619	NN	denotes	populations
T8457	620-626	VB	denotes	showed
T8458	627-636	RB	denotes	similarly
T8459	637-645	VB	denotes	enhanced
T8460	646-659	NN	denotes	proliferation
T8461	660-661	-LRB-	denotes	(
T8462	661-667	NN	denotes	Figure
T8463	668-670	NN	denotes	6A
T8464	670-671	-RRB-	denotes	)
T8465	673-684	RB	denotes	Furthermore
T8466	685-688	DT	denotes	the
T8467	689-703	JJ	denotes	TGF-β–mediated
T8468	704-713	NN	denotes	induction
T8469	714-716	IN	denotes	of
T8470	717-722	NN	denotes	FOXP3
T8471	723-733	NN	denotes	expression
T8472	734-737	VB	denotes	was
T8473	738-741	RB	denotes	not
T8474	742-748	VB	denotes	caused
T8475	749-751	IN	denotes	by
T8476	752-762	NN	denotes	overgrowth
T8477	763-765	IN	denotes	of
T8478	766-767	DT	denotes	a
T8479	768-779	JJ	denotes	CD25–FOXP3+
T8480	780-788	NN	denotes	minority
T8481	788-789	-COMMA-	denotes	,
T8482	790-795	IN	denotes	since
T8483	796-799	DT	denotes	the
T8484	800-806	NN	denotes	number
T8485	807-809	IN	denotes	of
T8486	810-816	JJ	denotes	FOXP3+
T8487	817-822	NN	denotes	cells
T8488	823-826	VB	denotes	was
T8489	827-837	JJ	denotes	low/absent
T8490	838-840	IN	denotes	in
T8491	841-844	DT	denotes	the
T8492	845-853	VB	denotes	purified
T8493	854-865	JJ	denotes	CD4+CD45RA+
T8494	866-867	NN	denotes	T
T8495	868-873	NN	denotes	cells
T8496	874-875	-LRB-	denotes	(
T8497	875-882	IN	denotes	between
T8498	883-884	CD	denotes	0
T8499	884-885	NN	denotes	%
T8500	886-889	CC	denotes	and
T8501	890-891	CD	denotes	1
T8502	891-892	NN	denotes	%
T8503	892-893	-RRB-	denotes	)
T8504	893-894	-COMMA-	denotes	,
T8505	895-898	CC	denotes	and
T8506	899-902	DT	denotes	the
T8507	903-909	JJ	denotes	FOXP3+
T8508	910-915	NN	denotes	cells
T8509	916-920	VB	denotes	were
T8510	921-924	RB	denotes	not
T8511	925-933	VB	denotes	confined
T8512	934-936	TO	denotes	to
T8513	937-940	DT	denotes	the
T8514	941-947	RB	denotes	highly
T8515	948-955	VB	denotes	divided
T8516	956-961	NN	denotes	cells
T8517	963-967	NN	denotes	CD25
T8518	968-971	VB	denotes	was
T8519	972-986	VB	denotes	down-regulated
T8520	987-989	IN	denotes	in
T8521	990-1003	JJ	denotes	TGF-β–treated
T8522	1004-1009	NN	denotes	cells
T8523	1010-1017	VB	denotes	compare
T8524	1018-1020	TO	denotes	to
T8525	1021-1030	VB	denotes	activated
T8526	1031-1032	NN	denotes	T
T8527	1033-1038	NN	denotes	cells
T8528	1038-1039	-COMMA-	denotes	,
T8529	1040-1045	WDT	denotes	which
T8530	1046-1049	VB	denotes	was
T8531	1050-1054	RB	denotes	even
T8532	1055-1059	RB	denotes	more
T8533	1060-1070	JJ	denotes	pronounced
T8534	1071-1073	IN	denotes	in
T8535	1074-1079	NN	denotes	cells
T8536	1080-1088	VB	denotes	cultured
T8537	1089-1093	IN	denotes	with
T8538	1094-1099	NN	denotes	TGF-β
T8539	1100-1103	CC	denotes	and
T8540	1104-1108	NN	denotes	IL-4
T8541	1735-1738	DT	denotes	The
T8542	1739-1747	NN	denotes	addition
T8543	1748-1750	IN	denotes	of
T8544	1751-1755	NN	denotes	IL-4
T8545	1756-1758	TO	denotes	to
T8546	1759-1772	JJ	denotes	iTreg-driving
T8547	1773-1783	NN	denotes	conditions
T8548	1784-1793	VB	denotes	decreased
T8549	1794-1797	DT	denotes	the
T8550	1798-1804	NN	denotes	number
T8551	1805-1807	IN	denotes	of
T8552	1808-1814	JJ	denotes	FOXP3+
T8553	1815-1820	NN	denotes	cells
T8554	1821-1822	-LRB-	denotes	(
T8555	1822-1828	NN	denotes	Figure
T8556	1829-1831	NN	denotes	6B
T8557	1831-1832	-RRB-	denotes	)
T8558	1834-1836	IN	denotes	In
T8559	1837-1841	NN	denotes	line
T8560	1842-1846	IN	denotes	with
T8561	1847-1850	DT	denotes	the
T8562	1851-1859	JJ	denotes	previous
T8563	1860-1868	NN	denotes	findings
T8564	1868-1869	-COMMA-	denotes	,
T8565	1870-1873	DT	denotes	the
T8566	1874-1888	JJ	denotes	IL-4–producing
T8567	1889-1894	NN	denotes	cells
T8568	1895-1898	CC	denotes	and
T8569	1899-1902	DT	denotes	the
T8570	1903-1908	NN	denotes	FOXP3
T8571	1909-1919	NN	denotes	expressing
T8572	1920-1925	NN	denotes	cells
T8573	1926-1929	VB	denotes	are
T8574	1930-1944	JJ	denotes	nonoverlapping
T8575	1945-1956	NN	denotes	populations
T8576	1958-1963	IN	denotes	Since
T8577	1964-1969	NN	denotes	FOXP3
T8578	1970-1972	VB	denotes	is
T8579	1973-1978	VB	denotes	known
T8580	1979-1981	TO	denotes	to
T8581	1982-1985	VB	denotes	act
T8582	1986-1988	IN	denotes	as
T8583	1989-1990	DT	denotes	a
T8584	1991-2000	NN	denotes	repressor
T8585	2001-2003	IN	denotes	of
T8586	2004-2012	NN	denotes	cytokine
T8587	2013-2023	NN	denotes	expression
T8588	2024-2025	-LRB-	denotes	[
T8589	2025-2027	CD	denotes	20
T8590	2027-2028	-RRB-	denotes	]
T8591	2028-2029	-COMMA-	denotes	,
T8592	2030-2032	PRP	denotes	we
T8593	2033-2042	RB	denotes	therefore
T8594	2043-2051	VB	denotes	analyzed
T8595	2052-2057	NN	denotes	GATA3
T8596	2058-2061	CC	denotes	and
T8597	2062-2067	NN	denotes	FOXP3
T8598	2068-2078	NN	denotes	expression
T8599	2080-2083	DT	denotes	The
T8600	2084-2094	NN	denotes	expression
T8601	2095-2102	JJ	denotes	kinetic
T8602	2103-2105	IN	denotes	of
T8603	2106-2111	JJ	denotes	naive
T8604	2112-2113	NN	denotes	T
T8605	2114-2119	NN	denotes	cells
T8606	2120-2127	VB	denotes	exposed
T8607	2128-2130	TO	denotes	to
T8608	2131-2135	NN	denotes	IL-4
T8609	2136-2139	CC	denotes	and
T8610	2140-2145	NN	denotes	TGF-β
T8611	2146-2158	VB	denotes	demonstrated
T8612	2159-2163	IN	denotes	that
T8613	2164-2169	NN	denotes	GATA3
T8614	2170-2173	CC	denotes	and
T8615	2174-2179	NN	denotes	FOXP3
T8616	2180-2183	VB	denotes	are
T8617	2184-2193	RB	denotes	initially
T8618	2194-2199	VB	denotes	found
T8619	2200-2202	IN	denotes	in
T8620	2203-2211	JJ	denotes	separate
T8621	2212-2223	NN	denotes	populations
T8622	2224-2225	-LRB-	denotes	(
T8623	2225-2228	NN	denotes	day
T8624	2229-2230	CD	denotes	2
T8625	2230-2231	-RRB-	denotes	)
T8626	2231-2232	-COMMA-	denotes	,
T8627	2233-2236	CC	denotes	but
T8628	2237-2248	RB	denotes	transiently
T8629	2249-2259	VB	denotes	co-express
T8630	2260-2264	DT	denotes	both
T8631	2265-2272	NN	denotes	factors
T8632	2273-2274	-LRB-	denotes	(
T8633	2274-2278	NN	denotes	days
T8634	2279-2282	CD	denotes	4–8
T8635	2282-2283	-RRB-	denotes	)
T8636	2283-2284	-COMMA-	denotes	,
T8637	2285-2291	IN	denotes	before
T8638	2292-2304	VB	denotes	establishing
T8639	2305-2313	JJ	denotes	separate
T8640	2314-2325	NN	denotes	populations
T8641	2326-2328	IN	denotes	at
T8642	2329-2332	DT	denotes	the
T8643	2333-2336	NN	denotes	end
T8644	2337-2339	IN	denotes	of
T8645	2340-2343	DT	denotes	the
T8646	2344-2359	NN	denotes	differentiation
T8647	2360-2367	NN	denotes	process
T8648	2368-2369	-LRB-	denotes	(
T8649	2369-2372	NN	denotes	day
T8650	2373-2375	CD	denotes	10
T8651	2375-2376	-COLON-	denotes	;
T8652	2377-2383	NN	denotes	Figure
T8653	2384-2386	NN	denotes	6C
T8654	2386-2387	-RRB-	denotes	)
T8655	2387-2388	-COMMA-	denotes	,
T8656	2389-2399	VB	denotes	suggesting
T8657	2400-2404	IN	denotes	that
T8658	2405-2410	NN	denotes	GATA3
T8659	2411-2419	VB	denotes	inhibits
T8660	2420-2423	DT	denotes	the
T8661	2424-2435	NN	denotes	development
T8662	2436-2438	IN	denotes	of
T8663	2439-2444	NN	denotes	iTreg
T8664	2445-2450	NN	denotes	cells
T8665	2451-2453	IN	denotes	by
T8666	2454-2464	VB	denotes	repressing
T8667	2465-2470	NN	denotes	FOXP3
T8668	2472-2477	DT	denotes	These
T8669	2478-2485	NN	denotes	results
T8670	2486-2492	VB	denotes	showed
T8671	2493-2497	IN	denotes	that
T8672	2498-2502	NN	denotes	IL-4
T8673	2503-2507	VB	denotes	acts
T8674	2508-2510	FW	denotes	in
T8675	2511-2516	FW	denotes	vitro
T8676	2517-2519	IN	denotes	as
T8677	2520-2522	DT	denotes	an
T8678	2523-2532	NN	denotes	inhibitor
T8679	2533-2535	IN	denotes	of
T8680	2536-2541	NN	denotes	FOXP3
T8681	2542-2552	NN	denotes	expression
T8682	2552-2553	-COMMA-	denotes	,
T8683	2554-2561	IN	denotes	without
T8684	2562-2573	VB	denotes	interfering
T8685	2574-2578	IN	denotes	with
T8686	2579-2584	NN	denotes	TGF-β
T8687	2585-2594	NN	denotes	signaling
T8688	2594-2595	-COMMA-	denotes	,
T8689	2596-2604	RB	denotes	probably
T8690	2605-2611	VB	denotes	acting
T8691	2612-2614	IN	denotes	at
T8692	2615-2618	DT	denotes	the
T8693	2619-2624	NN	denotes	level
T8694	2625-2627	IN	denotes	of
T8695	2628-2641	NN	denotes	transcription
T8696	2642-2649	NN	denotes	factors
T8697	2649-2650	-COMMA-	denotes	,
T8698	2651-2654	CC	denotes	and
T8699	2655-2663	RB	denotes	possibly
T8700	2664-2666	IN	denotes	by
T8701	2667-2668	DT	denotes	a
T8702	2669-2684	JJ	denotes	GATA3-dependent
T8703	2685-2694	NN	denotes	mechanism
T25880	1120-1124	NN	denotes	IL-4
T25881	1125-1133	VB	denotes	Inhibits
T25882	1134-1148	JJ	denotes	TGF-β–Mediated
T25883	1149-1154	NN	denotes	iTreg
T25884	1155-1165	NNP	denotes	Commitment
T25885	1166-1178	JJ	denotes	CFSE-labeled
T25886	1179-1190	JJ	denotes	CD4+CD45RA+
T25887	1191-1196	NN	denotes	cells
T25888	1197-1201	VB	denotes	were
T25889	1202-1211	VB	denotes	activated
T25890	1212-1216	IN	denotes	with
T25891	1217-1228	JJ	denotes	plate-bound
T25892	1229-1242	NN	denotes	anti-CD3/CD28
T25893	1242-1243	-COMMA-	denotes	,
T25894	1244-1249	NN	denotes	TGF-β
T25895	1249-1250	-COMMA-	denotes	,
T25896	1251-1254	CC	denotes	and
T25897	1255-1259	NN	denotes	IL-4
T25898	1259-1260	-COMMA-	denotes	,
T25899	1261-1263	IN	denotes	as
T25900	1264-1273	VB	denotes	indicated
T25901	1275-1280	IN	denotes	After
T25902	1281-1282	CD	denotes	5
T25903	1283-1284	NN	denotes	d
T25904	1284-1285	-COMMA-	denotes	,
T25905	1286-1291	NN	denotes	cells
T25906	1292-1296	VB	denotes	were
T25907	1297-1305	VB	denotes	analyzed
T25908	1306-1308	IN	denotes	by
T25909	1309-1313	NN	denotes	flow
T25910	1314-1323	NN	denotes	cytometry
T25911	1324-1325	-LRB-	denotes	(
T25912	1325-1326	NN	denotes	A
T25913	1326-1327	-RRB-	denotes	)
T25914	1328-1331	CC	denotes	and
T25915	1332-1339	NN	denotes	results
T25916	1340-1342	IN	denotes	of
T25917	1343-1346	CD	denotes	six
T25918	1347-1358	JJ	denotes	independent
T25919	1359-1370	NN	denotes	experiments
T25920	1371-1374	VB	denotes	are
T25921	1375-1380	VB	denotes	shown
T25922	1381-1383	IN	denotes	in
T25923	1384-1387	DT	denotes	the
T25924	1388-1391	NN	denotes	bar
T25925	1392-1397	NN	denotes	graph
T25926	1398-1403	IN	denotes	below
T25927	1404-1405	-LRB-	denotes	(
T25928	1405-1406	NN	denotes	B
T25929	1406-1407	-RRB-	denotes	)
T25930	1409-1420	JJ	denotes	Statistical
T25931	1421-1433	NN	denotes	significance
T25932	1434-1435	-LRB-	denotes	(
T25933	1435-1442	JJ	denotes	one-way
T25934	1443-1448	NNP	denotes	Anova
T25935	1448-1449	-COMMA-	denotes	,
T25936	1450-1462	NNP	denotes	Newman-Keuls
T25937	1462-1463	-RRB-	denotes	)
T25938	1464-1466	VB	denotes	is
T25939	1467-1476	VB	denotes	indicated
T25940	1477-1479	IN	denotes	by
T25941	1480-1489	NN	denotes	asterisks
T25942	1490-1491	-LRB-	denotes	(
T25943	1491-1494	NN	denotes	**p
T25944	1495-1496	SYM	denotes	≤
T25945	1497-1501	CD	denotes	0.01
T25946	1501-1502	-COMMA-	denotes	,
T25947	1503-1507	NN	denotes	***p
T25948	1508-1509	-COLON-	denotes	≤
T25949	1510-1515	CD	denotes	0.001
T25950	1515-1516	-RRB-	denotes	)
T25951	1516-1517	-LRB-	denotes	.
T25952	1518-1519	NN	denotes	(
T25953	1519-1520	-RRB-	denotes	C
T25954	1520-1527	JJ	denotes	) Kinet
T25955	1527-1535	NN	denotes	ic analy
T25956	1535-1537	IN	denotes	si
T25957	1537-1550	JJ	denotes	s of intracel
T25958	1550-1555	NN	denotes	lular
T25959	1556-1559	CC	denotes	GAT
T25960	1559-1564	NN	denotes	A3 an
T25961	1564-1572	NN	denotes	d FOXP3
T25962	1572-1574	VB	denotes	st
T25963	1574-1579	VB	denotes	ainin
T25964	1579-1581	IN	denotes	g
T25965	1581-1586	NN	denotes	is sh
T25966	1586-1587	NN	denotes	o
T25967	1587-1596	VB	denotes	wn in pan
T25968	1596-1604	NN	denotes	el C fol
T25969	1604-1606	IN	denotes	lo
T25970	1606-1617	JJ	denotes	wing exposu
T25971	1617-1618	NN	denotes	r
T25972	1618-1623	NN	denotes	e of
T25973	1623-1625	TO	denotes	CD
T25974	1625-1636	JJ	denotes	4+CD45RA+ T
T25975	1637-1638	-COMMA-	denotes	c
T25976	1638-1642	NN	denotes	ells
T25977	1643-1646	CC	denotes	to
T25978	1646-1651	NN	denotes	anti-
T25979	1675-1679	NN	denotes	Data
T25980	1680-1683	VB	denotes	are
T25981	1684-1698	JJ	denotes	representative
T25982	1699-1701	IN	denotes	of
T25983	1702-1707	CD	denotes	three
T25984	1708-1719	JJ	denotes	independent
T25985	1720-1731	NN	denotes	experiments
R6322	T8353	T8352	arg1Of	Role,The
R6323	T8353	T8354	arg1Of	Role,of
R6324	T8353	T8356	arg1Of	Role,in
R6325	T8355	T8354	arg2Of	TGF-β,of
R6326	T8359	T8356	arg2Of	Differentiation,in
R6327	T8359	T8357	arg1Of	Differentiation,T
R6328	T8359	T8358	arg1Of	Differentiation,Cell
R6329	T8362	T8361	arg1Of	CD25,TGF-β–reduced
R6330	T8362	T8363	arg1Of	CD25,","
R6331	T8363	T8367	arg1Of	",",and
R6332	T8365	T8363	arg2Of	expression,","
R6333	T8365	T8364	arg1Of	expression,IL-4
R6334	T8367	T8360	arg2Of	and,Although
R6335	T8367	T8366	arg1Of	and,","
R6336	T8369	T8367	arg2Of	expression,and
R6337	T8369	T8368	arg1Of	expression,CD25
R6338	T8369	T8370	arg1Of	expression,(
R6339	T8372	T8370	arg2Of	6B,(
R6340	T8372	T8371	arg1Of	6B,Figure
R6341	T8373	T8370	arg3Of	),(
R6342	T8375	T8377	arg1Of	IL-4,inhibited
R6343	T8377	T8360	arg1Of	inhibited,Although
R6344	T8377	T8374	arg1Of	inhibited,","
R6345	T8377	T8376	arg1Of	inhibited,significantly
R6346	T8377	T8391	arg1Of	inhibited,","
R6347	T8377	T8392	arg1Of	inhibited,as
R6348	T8379	T8377	arg2Of	induction,inhibited
R6349	T8379	T8378	arg1Of	induction,TGF-β–mediated
R6350	T8379	T8380	arg1Of	induction,of
R6351	T8379	T8382	arg1Of	induction,in
R6352	T8381	T8380	arg2Of	FOXP3,of
R6353	T8385	T8382	arg2Of	cells,in
R6354	T8385	T8383	arg1Of	cells,naive
R6355	T8385	T8384	arg1Of	cells,T
R6356	T8385	T8386	arg2Of	cells,driven
R6357	T8386	T8387	arg1Of	driven,toward
R6358	T8390	T8387	arg2Of	cells,toward
R6359	T8390	T8388	arg1Of	cells,FOXP3+
R6360	T8390	T8389	arg1Of	cells,T
R6361	T8393	T8392	arg2Of	shown,as
R6362	T8396	T8393	arg1Of	analysis,shown
R6363	T8396	T8394	arg2Of	analysis,by
R6364	T8396	T8395	arg1Of	analysis,FACS
R6365	T8396	T8397	arg1Of	analysis,(
R6366	T8399	T8397	arg2Of	6A,(
R6367	T8399	T8398	arg1Of	6A,Figure
R6368	T8400	T8397	arg3Of	),(
R6369	T8401	T8402	arg1Of	It,is
R6370	T8401	T8403	arg2Of	It,known
R6371	T8403	T8402	arg2Of	known,is
R6372	T8405	T8406	arg1Of	IL-4,is
R6373	T8405	T8412	arg1Of	IL-4,may
R6374	T8405	T8414	arg1Of	IL-4,favor
R6375	T8405	T8422	arg1Of	IL-4,decrease
R6376	T8406	T8411	arg1Of	is,and
R6377	T8410	T8406	arg2Of	factor,is
R6378	T8410	T8407	arg1Of	factor,a
R6379	T8410	T8408	arg1Of	factor,potent
R6380	T8410	T8409	arg1Of	factor,growth
R6381	T8411	T8403	arg3Of	and,known
R6382	T8411	T8404	arg1Of	and,that
R6383	T8414	T8420	arg1Of	favor,and
R6384	T8416	T8414	arg2Of	proliferation,favor
R6385	T8416	T8415	arg1Of	proliferation,the
R6386	T8416	T8417	arg1Of	proliferation,of
R6387	T8419	T8417	arg2Of	cells,of
R6388	T8419	T8418	arg1Of	cells,FOXP3–
R6389	T8420	T8411	arg2Of	and,and
R6390	T8420	T8412	arg2Of	and,may
R6391	T8420	T8413	arg1Of	and,therefore
R6392	T8422	T8420	arg2Of	decrease,and
R6393	T8422	T8421	arg1Of	decrease,thus
R6394	T8425	T8422	arg2Of	percentage,decrease
R6395	T8425	T8423	arg1Of	percentage,the
R6396	T8425	T8424	arg1Of	percentage,relative
R6397	T8425	T8426	arg1Of	percentage,of
R6398	T8428	T8426	arg2Of	cells,of
R6399	T8428	T8427	arg1Of	cells,FOXP3+
R6400	T8431	T8432	arg1Of	analysis,of
R6401	T8431	T8436	arg1Of	analysis,by
R6402	T8431	T8438	arg1Of	analysis,demonstrated
R6403	T8435	T8432	arg2Of	kinetics,of
R6404	T8435	T8433	arg1Of	kinetics,cell
R6405	T8435	T8434	arg1Of	kinetics,division
R6406	T8437	T8436	arg2Of	CFSE-labeling,by
R6407	T8438	T8429	arg1Of	demonstrated,However
R6408	T8438	T8430	arg1Of	demonstrated,","
R6409	T8440	T8441	arg1Of	IL-4,did
R6410	T8440	T8444	arg1Of	IL-4,promote
R6411	T8444	T8438	arg2Of	promote,demonstrated
R6412	T8444	T8439	arg1Of	promote,that
R6413	T8444	T8441	arg2Of	promote,did
R6414	T8444	T8442	arg1Of	promote,not
R6415	T8444	T8443	arg1Of	promote,differentially
R6416	T8444	T8449	arg1Of	promote,over
R6417	T8446	T8444	arg2Of	growth,promote
R6418	T8446	T8445	arg1Of	growth,cell
R6419	T8446	T8447	arg1Of	growth,of
R6420	T8448	T8447	arg2Of	FOXP3+,of
R6421	T8450	T8449	arg2Of	that,over
R6422	T8450	T8451	arg1Of	that,of
R6423	T8452	T8451	arg2Of	FOXP3–,of
R6424	T8454	T8453	arg2Of	fact,In
R6425	T8456	T8455	arg1Of	populations,both
R6426	T8456	T8457	arg1Of	populations,showed
R6427	T8457	T8453	arg1Of	showed,In
R6428	T8459	T8458	arg1Of	enhanced,similarly
R6429	T8460	T8457	arg2Of	proliferation,showed
R6430	T8460	T8459	arg1Of	proliferation,enhanced
R6431	T8460	T8461	arg1Of	proliferation,(
R6432	T8463	T8461	arg2Of	6A,(
R6433	T8463	T8462	arg1Of	6A,Figure
R6434	T8464	T8461	arg3Of	),(
R6435	T8468	T8466	arg1Of	induction,the
R6436	T8468	T8467	arg1Of	induction,TGF-β–mediated
R6437	T8468	T8469	arg1Of	induction,of
R6438	T8468	T8472	arg1Of	induction,was
R6439	T8468	T8474	arg2Of	induction,caused
R6440	T8471	T8469	arg2Of	expression,of
R6441	T8471	T8470	arg1Of	expression,FOXP3
R6442	T8474	T8465	arg1Of	caused,Furthermore
R6443	T8474	T8472	arg2Of	caused,was
R6444	T8474	T8473	arg1Of	caused,not
R6445	T8474	T8481	arg1Of	caused,","
R6446	T8474	T8482	arg1Of	caused,since
R6447	T8474	T8496	arg1Of	caused,(
R6448	T8474	T8505	arg1Of	caused,and
R6449	T8476	T8474	arg1Of	overgrowth,caused
R6450	T8476	T8475	arg2Of	overgrowth,by
R6451	T8476	T8477	arg1Of	overgrowth,of
R6452	T8480	T8477	arg2Of	minority,of
R6453	T8480	T8478	arg1Of	minority,a
R6454	T8480	T8479	arg1Of	minority,CD25–FOXP3+
R6455	T8484	T8483	arg1Of	number,the
R6456	T8484	T8485	arg1Of	number,of
R6457	T8484	T8488	arg1Of	number,was
R6458	T8484	T8489	arg1Of	number,low/absent
R6459	T8487	T8485	arg2Of	cells,of
R6460	T8487	T8486	arg1Of	cells,FOXP3+
R6461	T8488	T8482	arg2Of	was,since
R6462	T8488	T8490	arg1Of	was,in
R6463	T8489	T8488	arg2Of	low/absent,was
R6464	T8495	T8490	arg2Of	cells,in
R6465	T8495	T8491	arg1Of	cells,the
R6466	T8495	T8492	arg2Of	cells,purified
R6467	T8495	T8493	arg1Of	cells,CD4+CD45RA+
R6468	T8495	T8494	arg1Of	cells,T
R6469	T8499	T8498	arg1Of	%,0
R6470	T8499	T8500	arg1Of	%,and
R6471	T8501	T8500	arg2Of	1,and
R6472	T8502	T8496	arg2Of	%,(
R6473	T8502	T8497	arg1Of	%,between
R6474	T8502	T8499	arg1Of	%,%
R6475	T8502	T8501	arg1Of	%,1
R6476	T8503	T8496	arg3Of	),(
R6477	T8505	T8504	arg1Of	and,","
R6478	T8508	T8506	arg1Of	cells,the
R6479	T8508	T8507	arg1Of	cells,FOXP3+
R6480	T8508	T8509	arg1Of	cells,were
R6481	T8508	T8511	arg2Of	cells,confined
R6482	T8511	T8505	arg2Of	confined,and
R6483	T8511	T8509	arg2Of	confined,were
R6484	T8511	T8510	arg1Of	confined,not
R6485	T8511	T8512	arg1Of	confined,to
R6486	T8516	T8512	arg2Of	cells,to
R6487	T8516	T8513	arg1Of	cells,the
R6488	T8516	T8514	arg1Of	cells,highly
R6489	T8516	T8515	arg2Of	cells,divided
R6490	T8517	T8518	arg1Of	CD25,was
R6491	T8517	T8519	arg2Of	CD25,down-regulated
R6492	T8519	T8518	arg2Of	down-regulated,was
R6493	T8519	T8520	arg1Of	down-regulated,in
R6494	T8522	T8521	arg1Of	cells,TGF-β–treated
R6495	T8522	T8523	arg1Of	cells,compare
R6496	T8523	T8518	modOf	compare,was
R6497	T8523	T8524	arg1Of	compare,to
R6498	T8527	T8524	arg2Of	cells,to
R6499	T8527	T8525	arg2Of	cells,activated
R6500	T8527	T8526	arg1Of	cells,T
R6501	T8527	T8528	arg1Of	cells,","
R6502	T8527	T8529	arg1Of	cells,which
R6503	T8527	T8530	arg1Of	cells,was
R6504	T8527	T8533	arg1Of	cells,pronounced
R6505	T8530	T8534	arg1Of	was,in
R6506	T8532	T8531	arg1Of	more,even
R6507	T8533	T8530	arg2Of	pronounced,was
R6508	T8533	T8532	arg1Of	pronounced,more
R6509	T8535	T8534	arg2Of	cells,in
R6510	T8535	T8536	arg2Of	cells,cultured
R6511	T8536	T8537	arg1Of	cultured,with
R6512	T8538	T8539	arg1Of	TGF-β,and
R6513	T8539	T8537	arg2Of	and,with
R6514	T8540	T8539	arg2Of	IL-4,and
R6515	T8542	T8541	arg1Of	addition,The
R6516	T8542	T8543	arg1Of	addition,of
R6517	T8542	T8545	arg1Of	addition,to
R6518	T8542	T8548	arg1Of	addition,decreased
R6519	T8544	T8543	arg2Of	IL-4,of
R6520	T8547	T8545	arg2Of	conditions,to
R6521	T8547	T8546	arg1Of	conditions,iTreg-driving
R6522	T8550	T8548	arg2Of	number,decreased
R6523	T8550	T8549	arg1Of	number,the
R6524	T8550	T8551	arg1Of	number,of
R6525	T8553	T8551	arg2Of	cells,of
R6526	T8553	T8552	arg1Of	cells,FOXP3+
R6527	T8553	T8554	arg1Of	cells,(
R6528	T8556	T8554	arg2Of	6B,(
R6529	T8556	T8555	arg1Of	6B,Figure
R6530	T8557	T8554	arg3Of	),(
R6531	T8559	T8558	arg2Of	line,In
R6532	T8559	T8560	arg1Of	line,with
R6533	T8563	T8560	arg2Of	findings,with
R6534	T8563	T8561	arg1Of	findings,the
R6535	T8563	T8562	arg1Of	findings,previous
R6536	T8567	T8565	arg1Of	cells,the
R6537	T8567	T8566	arg1Of	cells,IL-4–producing
R6538	T8567	T8568	arg1Of	cells,and
R6539	T8568	T8573	arg1Of	and,are
R6540	T8572	T8568	arg2Of	cells,and
R6541	T8572	T8569	arg1Of	cells,the
R6542	T8572	T8570	arg1Of	cells,FOXP3
R6543	T8572	T8571	arg1Of	cells,expressing
R6544	T8573	T8558	arg1Of	are,In
R6545	T8573	T8564	arg1Of	are,","
R6546	T8575	T8573	arg2Of	populations,are
R6547	T8575	T8574	arg1Of	populations,nonoverlapping
R6548	T8577	T8578	arg1Of	FOXP3,is
R6549	T8577	T8579	arg2Of	FOXP3,known
R6550	T8577	T8581	arg1Of	FOXP3,act
R6551	T8579	T8576	arg2Of	known,Since
R6552	T8579	T8578	arg2Of	known,is
R6553	T8581	T8579	arg3Of	act,known
R6554	T8581	T8580	arg1Of	act,to
R6555	T8581	T8582	arg1Of	act,as
R6556	T8584	T8582	arg2Of	repressor,as
R6557	T8584	T8583	arg1Of	repressor,a
R6558	T8584	T8585	arg1Of	repressor,of
R6559	T8587	T8585	arg2Of	expression,of
R6560	T8587	T8586	arg1Of	expression,cytokine
R6561	T8587	T8588	arg1Of	expression,[
R6562	T8589	T8588	arg2Of	20,[
R6563	T8590	T8588	arg3Of	],[
R6564	T8592	T8594	arg1Of	we,analyzed
R6565	T8594	T8576	arg1Of	analyzed,Since
R6566	T8594	T8591	arg1Of	analyzed,","
R6567	T8594	T8593	arg1Of	analyzed,therefore
R6568	T8595	T8596	arg1Of	GATA3,and
R6569	T8597	T8596	arg2Of	FOXP3,and
R6570	T8598	T8594	arg2Of	expression,analyzed
R6571	T8598	T8595	arg1Of	expression,GATA3
R6572	T8598	T8597	arg1Of	expression,FOXP3
R6573	T8600	T8599	arg1Of	expression,The
R6574	T8600	T8601	arg1Of	expression,kinetic
R6575	T8600	T8611	arg1Of	expression,demonstrated
R6576	T8601	T8602	arg1Of	kinetic,of
R6577	T8605	T8602	arg2Of	cells,of
R6578	T8605	T8603	arg1Of	cells,naive
R6579	T8605	T8604	arg1Of	cells,T
R6580	T8605	T8606	arg2Of	cells,exposed
R6581	T8606	T8607	arg1Of	exposed,to
R6582	T8608	T8609	arg1Of	IL-4,and
R6583	T8609	T8607	arg2Of	and,to
R6584	T8610	T8609	arg2Of	TGF-β,and
R6585	T8613	T8614	arg1Of	GATA3,and
R6586	T8614	T8616	arg1Of	and,are
R6587	T8614	T8618	arg2Of	and,found
R6588	T8614	T8629	arg1Of	and,co-express
R6589	T8614	T8638	arg1Of	and,establishing
R6590	T8615	T8614	arg2Of	FOXP3,and
R6591	T8618	T8616	arg2Of	found,are
R6592	T8618	T8617	arg1Of	found,initially
R6593	T8618	T8619	arg1Of	found,in
R6594	T8618	T8627	arg1Of	found,but
R6595	T8621	T8619	arg2Of	populations,in
R6596	T8621	T8620	arg1Of	populations,separate
R6597	T8621	T8622	arg1Of	populations,(
R6598	T8623	T8622	arg2Of	day,(
R6599	T8623	T8624	arg1Of	day,2
R6600	T8625	T8622	arg3Of	),(
R6601	T8627	T8611	arg2Of	but,demonstrated
R6602	T8627	T8612	arg1Of	but,that
R6603	T8627	T8626	arg1Of	but,","
R6604	T8627	T8655	arg1Of	but,","
R6605	T8627	T8656	modOf	but,suggesting
R6606	T8629	T8627	arg2Of	co-express,but
R6607	T8629	T8628	arg1Of	co-express,transiently
R6608	T8629	T8636	arg1Of	co-express,","
R6609	T8629	T8637	arg1Of	co-express,before
R6610	T8631	T8629	arg2Of	factors,co-express
R6611	T8631	T8630	arg1Of	factors,both
R6612	T8631	T8632	arg1Of	factors,(
R6613	T8634	T8632	arg2Of	4–8,(
R6614	T8634	T8633	arg1Of	4–8,days
R6615	T8635	T8632	arg3Of	),(
R6616	T8638	T8637	arg2Of	establishing,before
R6617	T8638	T8641	arg1Of	establishing,at
R6618	T8640	T8638	arg2Of	populations,establishing
R6619	T8640	T8639	arg1Of	populations,separate
R6620	T8643	T8641	arg2Of	end,at
R6621	T8643	T8642	arg1Of	end,the
R6622	T8643	T8644	arg1Of	end,of
R6623	T8647	T8644	arg2Of	process,of
R6624	T8647	T8645	arg1Of	process,the
R6625	T8647	T8646	arg1Of	process,differentiation
R6626	T8647	T8648	arg1Of	process,(
R6627	T8649	T8650	arg1Of	day,10
R6628	T8649	T8651	arg1Of	day,;
R6629	T8651	T8648	arg2Of	;,(
R6630	T8653	T8651	arg2Of	6C,;
R6631	T8653	T8652	arg1Of	6C,Figure
R6632	T8654	T8648	arg3Of	),(
R6633	T8658	T8659	arg1Of	GATA3,inhibits
R6634	T8658	T8666	arg1Of	GATA3,repressing
R6635	T8659	T8656	arg2Of	inhibits,suggesting
R6636	T8659	T8657	arg1Of	inhibits,that
R6637	T8659	T8665	arg1Of	inhibits,by
R6638	T8661	T8659	arg2Of	development,inhibits
R6639	T8661	T8660	arg1Of	development,the
R6640	T8661	T8662	arg1Of	development,of
R6641	T8664	T8662	arg2Of	cells,of
R6642	T8664	T8663	arg1Of	cells,iTreg
R6643	T8666	T8665	arg2Of	repressing,by
R6644	T8667	T8666	arg2Of	FOXP3,repressing
R6645	T8669	T8668	arg1Of	results,These
R6646	T8669	T8670	arg1Of	results,showed
R6647	T8672	T8673	arg1Of	IL-4,acts
R6648	T8673	T8670	arg2Of	acts,showed
R6649	T8673	T8671	arg1Of	acts,that
R6650	T8673	T8675	arg1Of	acts,vitro
R6651	T8673	T8676	arg1Of	acts,as
R6652	T8673	T8682	arg1Of	acts,","
R6653	T8673	T8683	arg1Of	acts,without
R6654	T8673	T8700	arg1Of	acts,by
R6655	T8675	T8674	arg1Of	vitro,in
R6656	T8678	T8676	arg2Of	inhibitor,as
R6657	T8678	T8677	arg1Of	inhibitor,an
R6658	T8678	T8679	arg1Of	inhibitor,of
R6659	T8681	T8679	arg2Of	expression,of
R6660	T8681	T8680	arg1Of	expression,FOXP3
R6661	T8683	T8698	arg1Of	without,and
R6662	T8684	T8683	arg2Of	interfering,without
R6663	T8684	T8685	arg1Of	interfering,with
R6664	T8684	T8688	arg1Of	interfering,","
R6665	T8684	T8690	modOf	interfering,acting
R6666	T8687	T8685	arg2Of	signaling,with
R6667	T8687	T8686	arg1Of	signaling,TGF-β
R6668	T8690	T8689	arg1Of	acting,probably
R6669	T8690	T8691	arg1Of	acting,at
R6670	T8693	T8691	arg2Of	level,at
R6671	T8693	T8692	arg1Of	level,the
R6672	T8693	T8694	arg1Of	level,of
R6673	T8696	T8694	arg2Of	factors,of
R6674	T8696	T8695	arg1Of	factors,transcription
R6675	T8698	T8697	arg1Of	and,","
R6676	T8700	T8698	arg2Of	by,and
R6677	T8700	T8699	arg1Of	by,possibly
R6678	T8703	T8700	arg2Of	mechanism,by
R6679	T8703	T8701	arg1Of	mechanism,a
R6680	T8703	T8702	arg1Of	mechanism,GATA3-dependent
R19189	T25880	T25881	arg1Of	IL-4,Inhibits
R19190	T25884	T25881	arg2Of	Commitment,Inhibits
R19191	T25884	T25882	arg1Of	Commitment,TGF-β–Mediated
R19192	T25884	T25883	arg1Of	Commitment,iTreg
R19193	T25887	T25885	arg1Of	cells,CFSE-labeled
R19194	T25887	T25886	arg1Of	cells,CD4+CD45RA+
R19195	T25887	T25888	arg1Of	cells,were
R19196	T25887	T25889	arg2Of	cells,activated
R19197	T25889	T25888	arg2Of	activated,were
R19198	T25889	T25890	arg1Of	activated,with
R19199	T25889	T25898	arg1Of	activated,","
R19200	T25889	T25899	arg1Of	activated,as
R19201	T25892	T25891	arg1Of	anti-CD3/CD28,plate-bound
R19202	T25892	T25893	arg1Of	anti-CD3/CD28,","
R19203	T25893	T25896	arg1Of	",",and
R19204	T25894	T25893	arg2Of	TGF-β,","
R19205	T25896	T25890	arg2Of	and,with
R19206	T25896	T25895	arg1Of	and,","
R19207	T25897	T25896	arg2Of	IL-4,and
R19208	T25900	T25899	arg2Of	indicated,as
R19209	T25903	T25901	arg2Of	d,After
R19210	T25903	T25902	arg1Of	d,5
R19211	T25905	T25906	arg1Of	cells,were
R19212	T25905	T25907	arg2Of	cells,analyzed
R19213	T25907	T25906	arg2Of	analyzed,were
R19214	T25907	T25908	arg1Of	analyzed,by
R19215	T25907	T25914	arg1Of	analyzed,and
R19216	T25910	T25908	arg2Of	cytometry,by
R19217	T25910	T25909	arg1Of	cytometry,flow
R19218	T25910	T25911	arg1Of	cytometry,(
R19219	T25912	T25911	arg2Of	A,(
R19220	T25913	T25911	arg3Of	),(
R19221	T25914	T25901	arg1Of	and,After
R19222	T25914	T25904	arg1Of	and,","
R19223	T25915	T25916	arg1Of	results,of
R19224	T25915	T25920	arg1Of	results,are
R19225	T25915	T25921	arg2Of	results,shown
R19226	T25919	T25916	arg2Of	experiments,of
R19227	T25919	T25917	arg1Of	experiments,six
R19228	T25919	T25918	arg1Of	experiments,independent
R19229	T25921	T25914	arg2Of	shown,and
R19230	T25921	T25920	arg2Of	shown,are
R19231	T25921	T25922	arg1Of	shown,in
R19232	T25925	T25922	arg2Of	graph,in
R19233	T25925	T25923	arg1Of	graph,the
R19234	T25925	T25924	arg1Of	graph,bar
R19235	T25925	T25926	arg1Of	graph,below
R19236	T25925	T25927	arg1Of	graph,(
R19237	T25928	T25927	arg2Of	B,(
R19238	T25929	T25927	arg3Of	),(
R19239	T25931	T25930	arg1Of	significance,Statistical
R19240	T25931	T25932	arg1Of	significance,(
R19241	T25931	T25938	arg1Of	significance,is
R19242	T25931	T25939	arg2Of	significance,indicated
R19243	T25934	T25932	arg2Of	Anova,(
R19244	T25934	T25933	arg1Of	Anova,one-way
R19245	T25934	T25935	arg1Of	Anova,","
R19246	T25934	T25936	arg1Of	Anova,Newman-Keuls
R19247	T25937	T25932	arg3Of	),(
R19248	T25939	T25938	arg2Of	indicated,is
R19249	T25941	T25939	arg1Of	asterisks,indicated
R19250	T25941	T25940	arg2Of	asterisks,by
R19251	T25941	T25942	arg1Of	asterisks,(
R19252	T25941	T25962	modOf	asterisks,st
R19253	T25941	T25973	arg1Of	asterisks,CD
R19254	T25943	T25942	arg2Of	**p,(
R19255	T25943	T25944	arg1Of	**p,≤
R19256	T25943	T25945	arg1Of	**p,0.01
R19257	T25943	T25946	arg1Of	**p,","
R19258	T25949	T25946	arg2Of	0.001,","
R19259	T25949	T25947	arg1Of	0.001,***p
R19260	T25949	T25948	arg1Of	0.001,≤
R19261	T25950	T25942	arg3Of	),(
R19262	T25952	T25951	arg2Of	(,.
R19263	T25953	T25951	arg3Of	C,.
R19264	T25955	T25951	arg1Of	ic analy,.
R19265	T25955	T25954	arg1Of	ic analy,) Kinet
R19266	T25955	T25956	arg1Of	ic analy,si
R19267	T25955	T25962	arg1Of	ic analy,st
R19268	T25955	T25963	arg2Of	ic analy,ainin
R19269	T25958	T25959	arg1Of	lular,GAT
R19270	T25960	T25959	arg2Of	A3 an,GAT
R19271	T25961	T25956	arg2Of	d FOXP3 ,si
R19272	T25961	T25957	arg1Of	d FOXP3 ,s of intracel
R19273	T25961	T25958	arg1Of	d FOXP3 ,lular
R19274	T25961	T25960	arg1Of	d FOXP3 ,A3 an
R19275	T25963	T25962	arg2Of	ainin,st
R19276	T25963	T25964	arg1Of	ainin,g
R19277	T25963	T25967	arg1Of	ainin,wn in pan
R19278	T25966	T25964	arg2Of	o,g
R19279	T25966	T25965	arg1Of	o,is sh
R19280	T25968	T25967	arg2Of	el C fol,wn in pan
R19281	T25968	T25969	arg1Of	el C fol,lo
R19282	T25972	T25969	arg2Of	e of ,lo
R19283	T25972	T25970	arg1Of	e of ,wing exposu
R19284	T25972	T25971	arg1Of	e of ,r
R19285	T25976	T25977	arg1Of	ells,to
R19286	T25977	T25973	arg2Of	to ,CD
R19287	T25977	T25974	arg1Of	to ,4+CD45RA+ T
R19288	T25977	T25975	arg1Of	to ,c
R19289	T25978	T25977	arg2Of	anti-,to
R19290	T25979	T25980	arg1Of	Data,are
R19291	T25979	T25981	arg1Of	Data,representative
R19292	T25981	T25980	arg2Of	representative,are
R19293	T25981	T25982	arg1Of	representative,of
R19294	T25985	T25982	arg2Of	experiments,of
R19295	T25985	T25983	arg1Of	experiments,three
R19296	T25985	T25984	arg1Of	experiments,independent

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T8704	2260-2272	Anaphor	denotes	both factors
T8705	2164-2169	Antecedent	denotes	GATA3
T8706	2174-2179	Antecedent	denotes	FOXP3
R6681	T8704	T8705	boundBy	both factors,GATA3
R6682	T8704	T8706	boundBy	both factors,FOXP3

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T8764	0-3	DT	denotes	The
T8765	4-8	NNP	denotes	Role
T8766	9-11	IN	denotes	of
T8767	12-17	NNP	denotes	TGF-β
T8768	18-20	IN	denotes	in
T8769	21-22	NNP	denotes	T
T8770	23-27	NNP	denotes	Cell
T8771	28-43	NNP	denotes	Differentiation
T8772	44-52	IN	denotes	Although
T8773	53-58	NNP	denotes	TGF-β
T8774	59-66	VBD	denotes	reduced
T8775	67-71	NNP	denotes	CD25
T8776	71-72	,	denotes	,
T8777	73-77	NN	denotes	IL-4
T8778	78-88	NN	denotes	expression
T8779	88-89	,	denotes	,
T8780	90-93	CC	denotes	and
T8781	94-98	NNP	denotes	CD25
T8782	99-109	NN	denotes	expression
T8783	110-111	-LRB-	denotes	(
T8784	111-117	NN	denotes	Figure
T8785	118-120	NN	denotes	6B
T8786	120-121	-RRB-	denotes	)
T8787	121-122	,	denotes	,
T8788	123-127	NN	denotes	IL-4
T8789	128-141	RB	denotes	significantly
T8790	142-151	VBD	denotes	inhibited
T8791	152-157	NNP	denotes	TGF-β
T8792	158-166	VBD	denotes	mediated
T8793	167-176	NN	denotes	induction
T8794	177-179	IN	denotes	of
T8795	180-185	CD	denotes	FOXP3
T8796	186-188	IN	denotes	in
T8797	189-194	JJ	denotes	naive
T8798	195-196	NNP	denotes	T
T8799	197-202	NNS	denotes	cells
T8800	203-209	VBN	denotes	driven
T8801	210-216	IN	denotes	toward
T8802	217-222	CD	denotes	FOXP3
T8803	222-223	CD	denotes	+
T8804	224-225	NNP	denotes	T
T8805	226-231	NNS	denotes	cells
T8806	231-232	,	denotes	,
T8807	233-235	IN	denotes	as
T8808	236-241	VBN	denotes	shown
T8809	242-244	IN	denotes	by
T8810	245-249	NNP	denotes	FACS
T8811	250-258	NN	denotes	analysis
T8812	259-260	-LRB-	denotes	(
T8813	260-266	NN	denotes	Figure
T8814	267-269	NN	denotes	6A
T8815	269-270	-RRB-	denotes	)
T8816	270-271	.	denotes	.
T8817	272-274	PRP	denotes	It
T8818	275-277	VBZ	denotes	is
T8819	278-283	VBN	denotes	known
T8820	284-288	IN	denotes	that
T8821	289-293	NN	denotes	IL-4
T8822	294-296	VBZ	denotes	is
T8823	297-298	DT	denotes	a
T8824	299-305	JJ	denotes	potent
T8825	306-312	NN	denotes	growth
T8826	313-319	NN	denotes	factor
T8827	320-323	CC	denotes	and
T8828	324-327	MD	denotes	may
T8829	328-337	RB	denotes	therefore
T8830	338-343	VB	denotes	favor
T8831	344-347	DT	denotes	the
T8832	348-361	NN	denotes	proliferation
T8833	362-364	IN	denotes	of
T8834	365-370	CD	denotes	FOXP3
T8835	372-377	NNS	denotes	cells
T8836	378-381	CC	denotes	and
T8837	382-386	RB	denotes	thus
T8838	387-395	VB	denotes	decrease
T8839	396-399	DT	denotes	the
T8840	400-408	JJ	denotes	relative
T8841	409-419	NN	denotes	percentage
T8842	420-422	IN	denotes	of
T8843	423-428	CD	denotes	FOXP3
T8844	428-429	CD	denotes	+
T8845	430-435	NNS	denotes	cells
T8846	435-436	.	denotes	.
T8847	437-444	RB	denotes	However
T8848	444-445	,	denotes	,
T8849	446-454	NN	denotes	analysis
T8850	455-457	IN	denotes	of
T8851	458-462	NN	denotes	cell
T8852	463-471	NN	denotes	division
T8853	472-480	NNS	denotes	kinetics
T8854	481-483	IN	denotes	by
T8855	484-497	JJ	denotes	CFSE-labeling
T8856	498-510	VBD	denotes	demonstrated
T8857	511-515	IN	denotes	that
T8858	516-520	NN	denotes	IL-4
T8859	521-524	VBD	denotes	did
T8860	525-528	RB	denotes	not
T8861	529-543	RB	denotes	differentially
T8862	544-551	VB	denotes	promote
T8863	552-556	NN	denotes	cell
T8864	557-563	NN	denotes	growth
T8865	564-566	IN	denotes	of
T8866	567-572	CD	denotes	FOXP3
T8867	572-573	NN	denotes	+
T8868	574-578	IN	denotes	over
T8869	579-583	DT	denotes	that
T8870	584-586	IN	denotes	of
T8871	587-592	CD	denotes	FOXP3
T8872	593-594	.	denotes	.
T8873	595-597	IN	denotes	In
T8874	598-602	NN	denotes	fact
T8875	603-607	DT	denotes	both
T8876	608-619	NNS	denotes	populations
T8877	620-626	VBD	denotes	showed
T8878	627-636	RB	denotes	similarly
T8879	637-645	JJ	denotes	enhanced
T8880	646-659	NN	denotes	proliferation
T8881	660-661	-LRB-	denotes	(
T8882	661-667	NN	denotes	Figure
T8883	668-670	NN	denotes	6A
T8884	670-671	-RRB-	denotes	)
T8885	671-672	.	denotes	.
T8886	673-684	RB	denotes	Furthermore
T8887	685-688	DT	denotes	the
T8888	689-694	NNP	denotes	TGF-β
T8889	695-703	VBD	denotes	mediated
T8890	704-713	NN	denotes	induction
T8891	714-716	IN	denotes	of
T8892	717-722	CD	denotes	FOXP3
T8893	723-733	NN	denotes	expression
T8894	734-737	VBD	denotes	was
T8895	738-741	RB	denotes	not
T8896	742-748	VBN	denotes	caused
T8897	749-751	IN	denotes	by
T8898	752-762	NN	denotes	overgrowth
T8899	763-765	IN	denotes	of
T8900	766-767	DT	denotes	a
T8901	768-772	NNP	denotes	CD25
T8902	773-778	CD	denotes	FOXP3
T8903	778-779	NN	denotes	+
T8904	780-788	NN	denotes	minority
T8905	788-789	,	denotes	,
T8906	790-795	IN	denotes	since
T8907	796-799	DT	denotes	the
T8908	800-806	NN	denotes	number
T8909	807-809	IN	denotes	of
T8910	810-815	CD	denotes	FOXP3
T8911	815-816	CD	denotes	+
T8912	817-822	NNS	denotes	cells
T8913	823-826	VBD	denotes	was
T8914	827-837	JJ	denotes	low/absent
T8915	838-840	IN	denotes	in
T8916	841-844	DT	denotes	the
T8917	845-853	VBN	denotes	purified
T8918	854-857	NNP	denotes	CD4
T8919	857-858	NNP	denotes	+
T8920	858-864	NNP	denotes	CD45RA
T8921	864-865	VBD	denotes	+
T8922	866-867	NNP	denotes	T
T8923	868-873	NNS	denotes	cells
T8924	874-875	-LRB-	denotes	(
T8925	875-882	IN	denotes	between
T8926	883-884	CD	denotes	0
T8927	884-885	NN	denotes	%
T8928	886-889	CC	denotes	and
T8929	890-891	CD	denotes	1
T8930	891-892	NN	denotes	%
T8931	892-893	-RRB-	denotes	)
T8932	893-894	,	denotes	,
T8933	895-898	CC	denotes	and
T8934	899-902	DT	denotes	the
T8935	903-908	CD	denotes	FOXP3
T8936	908-909	NN	denotes	+
T8937	910-915	NNS	denotes	cells
T8938	916-920	VBD	denotes	were
T8939	921-924	RB	denotes	not
T8940	925-933	VBN	denotes	confined
T8941	934-936	TO	denotes	to
T8942	937-940	DT	denotes	the
T8943	941-947	RB	denotes	highly
T8944	948-955	VBN	denotes	divided
T8945	956-961	NNS	denotes	cells
T8946	961-962	.	denotes	.
T8947	963-967	CD	denotes	CD25
T8948	968-971	VBD	denotes	was
T8949	972-986	VBN	denotes	down-regulated
T8950	987-989	IN	denotes	in
T8951	990-995	NNP	denotes	TGF-β
T8952	996-1003	VBD	denotes	treated
T8953	1004-1009	NNS	denotes	cells
T8954	1010-1017	VB	denotes	compare
T8955	1018-1020	TO	denotes	to
T8956	1021-1030	VBN	denotes	activated
T8957	1031-1032	NNP	denotes	T
T8958	1033-1038	NNS	denotes	cells
T8959	1038-1039	,	denotes	,
T8960	1040-1045	WDT	denotes	which
T8961	1046-1049	VBD	denotes	was
T8962	1050-1054	RB	denotes	even
T8963	1055-1059	RBR	denotes	more
T8964	1060-1070	JJ	denotes	pronounced
T8965	1071-1073	IN	denotes	in
T8966	1074-1079	NNS	denotes	cells
T8967	1080-1088	VBN	denotes	cultured
T8968	1089-1093	IN	denotes	with
T8969	1094-1099	NNP	denotes	TGF-β
T8970	1100-1103	CC	denotes	and
T8971	1104-1108	NN	denotes	IL-4
T8972	1108-1109	.	denotes	.
T8973	1735-1738	DT	denotes	The
T8974	1739-1747	NN	denotes	addition
T8975	1748-1750	IN	denotes	of
T8976	1751-1755	NN	denotes	IL-4
T8977	1756-1758	TO	denotes	to
T8978	1759-1772	JJ	denotes	iTreg-driving
T8979	1773-1783	NNS	denotes	conditions
T8980	1784-1793	VBD	denotes	decreased
T8981	1794-1797	DT	denotes	the
T8982	1798-1804	NN	denotes	number
T8983	1805-1807	IN	denotes	of
T8984	1808-1813	CD	denotes	FOXP3
T8985	1813-1814	CD	denotes	+
T8986	1815-1820	NNS	denotes	cells
T8987	1821-1822	-LRB-	denotes	(
T8988	1822-1828	NN	denotes	Figure
T8989	1829-1831	NN	denotes	6B
T8990	1831-1832	-RRB-	denotes	)
T8991	1832-1833	.	denotes	.
T8992	1834-1836	IN	denotes	In
T8993	1837-1841	NN	denotes	line
T8994	1842-1846	IN	denotes	with
T8995	1847-1850	DT	denotes	the
T8996	1851-1859	JJ	denotes	previous
T8997	1860-1868	NNS	denotes	findings
T8998	1868-1869	,	denotes	,
T8999	1870-1873	DT	denotes	the
T9000	1874-1878	NN	denotes	IL-4
T9001	1879-1888	VBG	denotes	producing
T9002	1889-1894	NNS	denotes	cells
T9003	1895-1898	CC	denotes	and
T9004	1899-1902	DT	denotes	the
T9005	1903-1908	CD	denotes	FOXP3
T9006	1909-1919	VBG	denotes	expressing
T9007	1920-1925	NNS	denotes	cells
T9008	1926-1929	VBP	denotes	are
T9009	1930-1944	VBG	denotes	nonoverlapping
T9010	1945-1956	NNS	denotes	populations
T9011	1956-1957	.	denotes	.
T9012	1958-1963	IN	denotes	Since
T9013	1964-1969	CD	denotes	FOXP3
T9014	1970-1972	VBZ	denotes	is
T9015	1973-1978	VBN	denotes	known
T9016	1979-1981	TO	denotes	to
T9017	1982-1985	VB	denotes	act
T9018	1986-1988	IN	denotes	as
T9019	1989-1990	DT	denotes	a
T9020	1991-2000	NN	denotes	repressor
T9021	2001-2003	IN	denotes	of
T9022	2004-2012	NN	denotes	cytokine
T9023	2013-2023	NN	denotes	expression
T9024	2024-2025	NNP	denotes	[
T9025	2025-2027	CD	denotes	20
T9026	2027-2028	NNP	denotes	]
T9027	2028-2029	,	denotes	,
T9028	2030-2032	PRP	denotes	we
T9029	2033-2042	RB	denotes	therefore
T9030	2043-2051	VBD	denotes	analyzed
T9031	2052-2057	NNP	denotes	GATA3
T9032	2058-2061	CC	denotes	and
T9033	2062-2067	NNP	denotes	FOXP3
T9034	2068-2078	NN	denotes	expression
T9035	2078-2079	.	denotes	.
T9036	2080-2083	DT	denotes	The
T9037	2084-2094	NN	denotes	expression
T9038	2095-2102	NN	denotes	kinetic
T9039	2103-2105	IN	denotes	of
T9040	2106-2111	JJ	denotes	naive
T9041	2112-2113	NNP	denotes	T
T9042	2114-2119	NNS	denotes	cells
T9043	2120-2127	VBN	denotes	exposed
T9044	2128-2130	TO	denotes	to
T9045	2131-2135	NN	denotes	IL-4
T9046	2136-2139	CC	denotes	and
T9047	2140-2145	JJ	denotes	TGF-β
T9048	2146-2158	VBD	denotes	demonstrated
T9049	2159-2163	IN	denotes	that
T9050	2164-2169	NNP	denotes	GATA3
T9051	2170-2173	CC	denotes	and
T9052	2174-2179	NNP	denotes	FOXP3
T9053	2180-2183	VBP	denotes	are
T9054	2184-2193	RB	denotes	initially
T9055	2194-2199	VBN	denotes	found
T9056	2200-2202	IN	denotes	in
T9057	2203-2211	JJ	denotes	separate
T9058	2212-2223	NNS	denotes	populations
T9059	2224-2225	-LRB-	denotes	(
T9060	2225-2228	NN	denotes	day
T9061	2229-2230	CD	denotes	2
T9062	2230-2231	-RRB-	denotes	)
T9063	2231-2232	,	denotes	,
T9064	2233-2236	CC	denotes	but
T9065	2237-2248	RB	denotes	transiently
T9066	2249-2259	JJ	denotes	co-express
T9067	2260-2264	DT	denotes	both
T9068	2265-2272	NNS	denotes	factors
T9069	2273-2274	-LRB-	denotes	(
T9070	2274-2278	NNS	denotes	days
T9071	2279-2280	CD	denotes	4
T9072	2281-2282	CD	denotes	8
T9073	2282-2283	-RRB-	denotes	)
T9074	2283-2284	,	denotes	,
T9075	2285-2291	IN	denotes	before
T9076	2292-2304	VBG	denotes	establishing
T9077	2305-2313	JJ	denotes	separate
T9078	2314-2325	NNS	denotes	populations
T9079	2326-2328	IN	denotes	at
T9080	2329-2332	DT	denotes	the
T9081	2333-2336	NN	denotes	end
T9082	2337-2339	IN	denotes	of
T9083	2340-2343	DT	denotes	the
T9084	2344-2359	NN	denotes	differentiation
T9085	2360-2367	NN	denotes	process
T9086	2368-2369	-LRB-	denotes	(
T9087	2369-2372	NN	denotes	day
T9088	2373-2375	CD	denotes	10
T9089	2375-2376	:	denotes	;
T9090	2377-2383	NN	denotes	Figure
T9091	2384-2386	NN	denotes	6C
T9092	2386-2387	-RRB-	denotes	)
T9093	2387-2388	,	denotes	,
T9094	2389-2399	VBG	denotes	suggesting
T9095	2400-2404	IN	denotes	that
T9096	2405-2410	NNP	denotes	GATA3
T9097	2411-2419	VBZ	denotes	inhibits
T9098	2420-2423	DT	denotes	the
T9099	2424-2435	NN	denotes	development
T9100	2436-2438	IN	denotes	of
T9101	2439-2444	NNP	denotes	iTreg
T9102	2445-2450	NNS	denotes	cells
T9103	2451-2453	IN	denotes	by
T9104	2454-2464	VBG	denotes	repressing
T9105	2465-2470	NNP	denotes	FOXP3
T9106	2470-2471	.	denotes	.
T9107	2472-2477	DT	denotes	These
T9108	2478-2485	NNS	denotes	results
T9109	2486-2492	VBD	denotes	showed
T9110	2493-2497	IN	denotes	that
T9111	2498-2502	NN	denotes	IL-4
T9112	2503-2507	NNS	denotes	acts
T9113	2508-2510	IN	denotes	in
T9114	2511-2516	NN	denotes	vitro
T9115	2517-2519	IN	denotes	as
T9116	2520-2522	DT	denotes	an
T9117	2523-2532	NN	denotes	inhibitor
T9118	2533-2535	IN	denotes	of
T9119	2536-2541	CD	denotes	FOXP3
T9120	2542-2552	NN	denotes	expression
T9121	2552-2553	,	denotes	,
T9122	2554-2561	IN	denotes	without
T9123	2562-2573	VBG	denotes	interfering
T9124	2574-2578	IN	denotes	with
T9125	2579-2584	JJ	denotes	TGF-β
T9126	2585-2594	VBG	denotes	signaling
T9127	2594-2595	,	denotes	,
T9128	2596-2604	RB	denotes	probably
T9129	2605-2611	VBG	denotes	acting
T9130	2612-2614	IN	denotes	at
T9131	2615-2618	DT	denotes	the
T9132	2619-2624	NN	denotes	level
T9133	2625-2627	IN	denotes	of
T9134	2628-2641	NN	denotes	transcription
T9135	2642-2649	NNS	denotes	factors
T9136	2649-2650	,	denotes	,
T9137	2651-2654	CC	denotes	and
T9138	2655-2663	RB	denotes	possibly
T9139	2664-2666	IN	denotes	by
T9140	2667-2668	DT	denotes	a
T9141	2669-2684	JJ	denotes	GATA3-dependent
T9142	2685-2694	NN	denotes	mechanism
T9143	2694-2695	.	denotes	.
T26012	1120-1124	NN	denotes	IL-4
T26013	1125-1133	NNS	denotes	Inhibits
T26014	1134-1139	JJ	denotes	TGF-β
T26015	1140-1148	NNP	denotes	Mediated
T26016	1149-1154	NNP	denotes	iTreg
T26017	1155-1165	NNP	denotes	Commitment
T26018	1166-1178	NNP	denotes	CFSE-labeled
T26019	1179-1182	NNP	denotes	CD4
T26020	1182-1183	NNP	denotes	+
T26021	1183-1189	NNP	denotes	CD45RA
T26022	1189-1190	VBD	denotes	+
T26023	1191-1196	NNS	denotes	cells
T26024	1197-1201	VBD	denotes	were
T26025	1202-1211	VBN	denotes	activated
T26026	1212-1216	IN	denotes	with
T26027	1217-1228	JJ	denotes	plate-bound
T26028	1229-1237	JJ	denotes	anti-CD3
T26029	1237-1238	NN	denotes	/
T26030	1238-1242	NNP	denotes	CD28
T26031	1242-1243	,	denotes	,
T26032	1244-1249	NNP	denotes	TGF-β
T26033	1249-1250	,	denotes	,
T26034	1251-1254	CC	denotes	and
T26035	1255-1259	NN	denotes	IL-4
T26036	1259-1260	,	denotes	,
T26037	1261-1263	IN	denotes	as
T26038	1264-1273	VBN	denotes	indicated
T26039	1273-1274	.	denotes	.
T26040	1275-1280	IN	denotes	After
T26041	1281-1282	CD	denotes	5
T26042	1283-1284	LS	denotes	d
T26043	1284-1285	,	denotes	,
T26044	1286-1291	NNS	denotes	cells
T26045	1292-1296	VBD	denotes	were
T26046	1297-1305	VBN	denotes	analyzed
T26047	1306-1308	IN	denotes	by
T26048	1309-1313	NN	denotes	flow
T26049	1314-1323	NN	denotes	cytometry
T26050	1324-1325	-LRB-	denotes	(
T26051	1325-1326	NNP	denotes	A
T26052	1326-1327	-RRB-	denotes	)
T26053	1328-1331	CC	denotes	and
T26054	1332-1339	NNS	denotes	results
T26055	1340-1342	IN	denotes	of
T26056	1343-1346	CD	denotes	six
T26057	1347-1358	JJ	denotes	independent
T26058	1359-1370	NNS	denotes	experiments
T26059	1371-1374	VBP	denotes	are
T26060	1375-1380	VBN	denotes	shown
T26061	1381-1383	IN	denotes	in
T26062	1384-1387	DT	denotes	the
T26063	1388-1391	NN	denotes	bar
T26064	1392-1397	NN	denotes	graph
T26065	1398-1403	IN	denotes	below
T26066	1404-1405	-LRB-	denotes	(
T26067	1405-1406	NNP	denotes	B
T26068	1406-1407	-RRB-	denotes	)
T26069	1407-1408	.	denotes	.
T26070	1409-1420	NNP	denotes	Statistical
T26071	1421-1433	NN	denotes	significance
T26072	1434-1435	-LRB-	denotes	(
T26073	1435-1442	JJ	denotes	one-way
T26074	1443-1448	NNP	denotes	Anova
T26075	1448-1449	,	denotes	,
T26076	1450-1462	NNP	denotes	Newman-Keuls
T26077	1462-1463	-RRB-	denotes	)
T26078	1464-1466	VBZ	denotes	is
T26079	1467-1476	VBN	denotes	indicated
T26080	1477-1479	IN	denotes	by
T26081	1480-1489	NNS	denotes	asterisks
T26082	1490-1491	-LRB-	denotes	(
T26083	1491-1493	SYM	denotes	**
T26084	1493-1494	FW	denotes	p
T26085	1495-1496	FW	denotes	≤
T26086	1497-1501	CD	denotes	0.01
T26087	1501-1502	,	denotes	,
T26088	1503-1506	FW	denotes	***
T26089	1506-1507	FW	denotes	p
T26090	1508-1509	FW	denotes	≤
T26091	1510-1515	CD	denotes	0.001
T26092	1515-1516	-RRB-	denotes	)
T26093	1516-1517	.	denotes	.
T26094	1518-1519	-LRB-	denotes	(
T26095	1519-1520	$	denotes	C
T26096	1520-1521	-RRB-	denotes	)
T26097	1522-1529	JJ	denotes	Kinetic
T26098	1530-1538	NN	denotes	analysis
T26099	1539-1541	IN	denotes	of
T26100	1542-1555	JJ	denotes	intracellular
T26101	1556-1561	NNP	denotes	GATA3
T26102	1562-1565	CC	denotes	and
T26103	1566-1571	NNP	denotes	FOXP3
T26104	1572-1580	NN	denotes	staining
T26105	1581-1583	VBZ	denotes	is
T26106	1584-1589	VBN	denotes	shown
T26107	1590-1592	IN	denotes	in
T26108	1593-1598	NN	denotes	panel
T26109	1599-1600	NNP	denotes	C
T26110	1601-1610	VBG	denotes	following
T26111	1611-1619	NN	denotes	exposure
T26112	1620-1622	IN	denotes	of
T26113	1623-1626	NNP	denotes	CD4
T26114	1626-1627	NNP	denotes	+
T26115	1627-1633	NNP	denotes	CD45RA
T26116	1633-1634	VBD	denotes	+
T26117	1635-1636	NNP	denotes	T
T26118	1637-1642	NNS	denotes	cells
T26119	1643-1645	TO	denotes	to
T26120	1646-1654	JJ	denotes	anti-CD3
T26121	1654-1655	NN	denotes	/
T26122	1655-1657	CD	denotes	28
T26123	1657-1658	,	denotes	,
T26124	1659-1663	NN	denotes	IL-4
T26125	1664-1667	CC	denotes	and
T26126	1668-1673	NN	denotes	TGF-β
T26127	1673-1674	.	denotes	.
T26128	1675-1679	NNS	denotes	Data
T26129	1680-1683	VBP	denotes	are
T26130	1684-1698	NN	denotes	representative
T26131	1699-1701	IN	denotes	of
T26132	1702-1707	CD	denotes	three
T26133	1708-1719	JJ	denotes	independent
T26134	1720-1731	NNS	denotes	experiments
T26135	1731-1732	.	denotes	.
R6683	T8764	T8765	det	The,Role
R6684	T8765	T8765	ROOT	Role,Role
R6685	T8766	T8765	prep	of,Role
R6686	T8767	T8766	pobj	TGF-β,of
R6687	T8768	T8765	prep	in,Role
R6688	T8769	T8771	compound	T,Differentiation
R6689	T8770	T8771	compound	Cell,Differentiation
R6690	T8771	T8768	pobj	Differentiation,in
R6691	T8772	T8774	mark	Although,reduced
R6692	T8773	T8774	nsubj	TGF-β,reduced
R6693	T8774	T8790	advcl	reduced,inhibited
R6694	T8775	T8774	dobj	CD25,reduced
R6695	T8776	T8775	punct	",",CD25
R6696	T8777	T8778	compound	IL-4,expression
R6697	T8778	T8775	appos	expression,CD25
R6698	T8779	T8775	punct	",",CD25
R6699	T8780	T8775	cc	and,CD25
R6700	T8781	T8782	compound	CD25,expression
R6701	T8782	T8775	conj	expression,CD25
R6702	T8783	T8785	punct	(,6B
R6703	T8784	T8785	nmod	Figure,6B
R6704	T8785	T8782	appos	6B,expression
R6705	T8786	T8785	punct	),6B
R6706	T8787	T8790	punct	",",inhibited
R6707	T8788	T8790	nsubj	IL-4,inhibited
R6708	T8789	T8790	advmod	significantly,inhibited
R6709	T8790	T8790	ROOT	inhibited,inhibited
R6710	T8791	T8790	dobj	TGF-β,inhibited
R6711	T8792	T8790	conj	mediated,inhibited
R6712	T8793	T8792	dobj	induction,mediated
R6713	T8794	T8793	prep	of,induction
R6714	T8795	T8794	pobj	FOXP3,of
R6715	T8796	T8795	prep	in,FOXP3
R6716	T8797	T8799	amod	naive,cells
R6717	T8798	T8799	compound	T,cells
R6718	T8799	T8796	pobj	cells,in
R6719	T8800	T8792	conj	driven,mediated
R6720	T8801	T8800	prep	toward,driven
R6721	T8802	T8805	nummod	FOXP3,cells
R6722	T8803	T8805	nummod	+,cells
R6723	T8804	T8805	compound	T,cells
R6724	T8805	T8801	pobj	cells,toward
R6725	T8806	T8800	punct	",",driven
R6726	T8807	T8808	mark	as,shown
R6727	T8808	T8800	advcl	shown,driven
R6728	T8809	T8808	agent	by,shown
R6729	T8810	T8811	compound	FACS,analysis
R6730	T8811	T8809	pobj	analysis,by
R6731	T8812	T8814	punct	(,6A
R6732	T8813	T8814	compound	Figure,6A
R6733	T8814	T8811	appos	6A,analysis
R6734	T8815	T8800	punct	),driven
R6735	T8816	T8790	punct	.,inhibited
R6736	T8817	T8819	nsubjpass	It,known
R6737	T8818	T8819	auxpass	is,known
R6738	T8819	T8819	ROOT	known,known
R6739	T8820	T8822	mark	that,is
R6740	T8821	T8822	nsubj	IL-4,is
R6741	T8822	T8819	ccomp	is,known
R6742	T8823	T8826	det	a,factor
R6743	T8824	T8826	amod	potent,factor
R6744	T8825	T8826	compound	growth,factor
R6745	T8826	T8822	attr	factor,is
R6746	T8827	T8822	cc	and,is
R6747	T8828	T8830	aux	may,favor
R6748	T8829	T8830	advmod	therefore,favor
R6749	T8830	T8822	conj	favor,is
R6750	T8831	T8832	det	the,proliferation
R6751	T8832	T8830	dobj	proliferation,favor
R6752	T8833	T8832	prep	of,proliferation
R6753	T8834	T8833	pobj	FOXP3,of
R6754	T8835	T8832	appos	cells,proliferation
R6755	T8836	T8830	cc	and,favor
R6756	T8837	T8838	advmod	thus,decrease
R6757	T8838	T8830	conj	decrease,favor
R6758	T8839	T8841	det	the,percentage
R6759	T8840	T8841	amod	relative,percentage
R6760	T8841	T8838	dobj	percentage,decrease
R6761	T8842	T8841	prep	of,percentage
R6762	T8843	T8845	nummod	FOXP3,cells
R6763	T8844	T8845	nummod	+,cells
R6764	T8845	T8842	pobj	cells,of
R6765	T8846	T8819	punct	.,known
R6766	T8847	T8856	advmod	However,demonstrated
R6767	T8848	T8856	punct	",",demonstrated
R6768	T8849	T8856	nsubj	analysis,demonstrated
R6769	T8850	T8849	prep	of,analysis
R6770	T8851	T8852	compound	cell,division
R6771	T8852	T8853	compound	division,kinetics
R6772	T8853	T8850	pobj	kinetics,of
R6773	T8854	T8849	prep	by,analysis
R6774	T8855	T8854	pobj	CFSE-labeling,by
R6775	T8856	T8856	ROOT	demonstrated,demonstrated
R6776	T8857	T8862	mark	that,promote
R6781	T8862	T8856	ccomp	promote,demonstrated
R6782	T8863	T8864	compound	cell,growth
R6783	T8864	T8862	dobj	growth,promote
R6784	T8865	T8864	prep	of,growth
R6785	T8866	T8867	nummod	FOXP3,+
R6786	T8867	T8865	pobj	+,of
R6787	T8868	T8864	prep	over,growth
R6788	T8869	T8868	pobj	that,over
R6789	T8870	T8869	prep	of,that
R6790	T8871	T8870	pobj	FOXP3,of
R6791	T8872	T8856	punct	.,demonstrated
R6792	T8873	T8877	prep	In,showed
R6793	T8874	T8873	pobj	fact,In
R6794	T8875	T8876	det	both,populations
R6795	T8876	T8877	nsubj	populations,showed
R6796	T8877	T8877	ROOT	showed,showed
R6797	T8878	T8879	advmod	similarly,enhanced
R6798	T8879	T8880	amod	enhanced,proliferation
R6799	T8880	T8877	dobj	proliferation,showed
R6800	T8881	T8883	punct	(,6A
R6801	T8882	T8883	compound	Figure,6A
R6802	T8883	T8880	appos	6A,proliferation
R6803	T8884	T8880	punct	),proliferation
R6804	T8885	T8877	punct	.,showed
R6805	T8886	T8889	advmod	Furthermore,mediated
R6806	T8887	T8888	det	the,TGF-β
R6807	T8888	T8889	nsubj	TGF-β,mediated
R6808	T8889	T8889	ROOT	mediated,mediated
R6809	T8890	T8889	dobj	induction,mediated
R6810	T8891	T8890	prep	of,induction
R6811	T8892	T8893	amod	FOXP3,expression
R6812	T8893	T8891	pobj	expression,of
R6813	T8894	T8896	auxpass	was,caused
R6814	T8895	T8896	neg	not,caused
R6815	T8896	T8889	conj	caused,mediated
R6816	T8897	T8896	agent	by,caused
R6817	T8898	T8897	pobj	overgrowth,by
R6818	T8899	T8898	prep	of,overgrowth
R6819	T8900	T8901	det	a,CD25
R6820	T8901	T8899	pobj	CD25,of
R6821	T8902	T8904	nummod	FOXP3,minority
R6822	T8903	T8904	compound	+,minority
R6823	T8904	T8896	advmod	minority,caused
R6824	T8905	T8896	punct	",",caused
R6825	T8906	T8913	mark	since,was
R6826	T8907	T8908	det	the,number
R6827	T8908	T8913	nsubj	number,was
R6828	T8909	T8908	prep	of,number
R6829	T8910	T8912	nummod	FOXP3,cells
R6830	T8911	T8912	nummod	+,cells
R6831	T8912	T8909	pobj	cells,of
R6832	T8913	T8896	advcl	was,caused
R6833	T8914	T8913	acomp	low/absent,was
R6834	T8915	T8914	prep	in,low/absent
R6835	T8916	T8920	det	the,CD45RA
R6836	T8917	T8918	amod	purified,CD4
R6837	T8918	T8920	compound	CD4,CD45RA
R6838	T8919	T8920	compound	+,CD45RA
R6839	T8920	T8915	pobj	CD45RA,in
R6840	T8921	T8923	amod	+,cells
R6841	T8922	T8923	compound	T,cells
R6842	T8923	T8915	pobj	cells,in
R6843	T8924	T8940	punct	(,confined
R6844	T8925	T8926	quantmod	between,0
R6845	T8926	T8940	meta	0,confined
R6846	T8927	T8926	quantmod	%,0
R6847	T8928	T8927	cc	and,%
R6848	T8929	T8930	nummod	1,%
R6849	T8930	T8927	conj	%,%
R6850	T8931	T8926	punct	),0
R6861	T8942	T8945	det	the,cells
R6862	T8943	T8944	advmod	highly,divided
R6863	T8944	T8945	amod	divided,cells
R6864	T8945	T8941	pobj	cells,to
R6865	T8946	T8889	punct	.,mediated
R6866	T8947	T8949	nsubjpass	CD25,down-regulated
R6867	T8948	T8949	auxpass	was,down-regulated
R6868	T8949	T8949	ROOT	down-regulated,down-regulated
R6869	T8950	T8949	prep	in,down-regulated
R6870	T8951	T8950	pobj	TGF-β,in
R6871	T8952	T8953	amod	treated,cells
R6872	T8953	T8954	nsubj	cells,compare
R6873	T8954	T8954	ROOT	compare,compare
R6874	T8955	T8956	aux	to,activated
R6875	T8956	T8958	amod	activated,cells
R6876	T8957	T8958	compound	T,cells
R6877	T8958	T8954	dobj	cells,compare
R6878	T8959	T8958	punct	",",cells
R6879	T8960	T8961	nsubj	which,was
R6880	T8961	T8958	relcl	was,cells
R6881	T8962	T8963	advmod	even,more
R6882	T8963	T8964	advmod	more,pronounced
R6883	T8964	T8961	acomp	pronounced,was
R6884	T8965	T8964	prep	in,pronounced
R6885	T8966	T8965	pobj	cells,in
R6886	T8967	T8966	acl	cultured,cells
R6887	T8968	T8967	prep	with,cultured
R6888	T8969	T8968	pobj	TGF-β,with
R6889	T8970	T8969	cc	and,TGF-β
R6890	T8971	T8969	conj	IL-4,TGF-β
R6891	T8972	T8954	punct	.,compare
R6892	T8973	T8974	det	The,addition
R6893	T8974	T8980	nsubj	addition,decreased
R6894	T8975	T8974	prep	of,addition
R6895	T8976	T8975	pobj	IL-4,of
R6896	T8977	T8976	prep	to,IL-4
R6897	T8978	T8979	amod	iTreg-driving,conditions
R6898	T8979	T8977	pobj	conditions,to
R6899	T8980	T8980	ROOT	decreased,decreased
R6900	T8981	T8982	det	the,number
R6901	T8982	T8980	dobj	number,decreased
R6902	T8983	T8982	prep	of,number
R6903	T8984	T8986	nummod	FOXP3,cells
R6904	T8985	T8986	nummod	+,cells
R6905	T8986	T8983	pobj	cells,of
R6906	T8987	T8989	punct	(,6B
R6907	T8988	T8989	compound	Figure,6B
R6908	T8989	T8986	appos	6B,cells
R6909	T8990	T8980	punct	),decreased
R6910	T8991	T8980	punct	.,decreased
R6911	T8992	T9009	prep	In,nonoverlapping
R6912	T8993	T8992	pobj	line,In
R6913	T8994	T8993	prep	with,line
R6914	T8995	T8997	det	the,findings
R6915	T8996	T8997	amod	previous,findings
R6916	T8997	T8994	pobj	findings,with
R6917	T8998	T9009	punct	",",nonoverlapping
R6918	T8999	T9000	det	the,IL-4
R6919	T9000	T9009	nsubj	IL-4,nonoverlapping
R6920	T9001	T9000	acl	producing,IL-4
R6921	T9002	T9001	dobj	cells,producing
R6922	T9003	T9002	cc	and,cells
R6923	T9004	T9007	det	the,cells
R6924	T9005	T9007	nummod	FOXP3,cells
R6925	T9006	T9007	amod	expressing,cells
R6926	T9007	T9002	conj	cells,cells
R6927	T9008	T9009	aux	are,nonoverlapping
R6928	T9009	T9009	ROOT	nonoverlapping,nonoverlapping
R6929	T9010	T9009	dobj	populations,nonoverlapping
R6936	T9017	T9015	xcomp	act,known
R6937	T9018	T9017	prep	as,act
R6938	T9019	T9020	det	a,repressor
R6939	T9020	T9018	pobj	repressor,as
R6940	T9021	T9020	prep	of,repressor
R6941	T9022	T9023	compound	cytokine,expression
R6942	T9023	T9021	pobj	expression,of
R6943	T9024	T9026	nmod	[,]
R6944	T9025	T9026	nummod	20,]
R6945	T9026	T9020	appos	],repressor
R6946	T9027	T9030	punct	",",analyzed
R6947	T9028	T9030	nsubj	we,analyzed
R6948	T9029	T9030	advmod	therefore,analyzed
R6949	T9030	T9030	ROOT	analyzed,analyzed
R6950	T9031	T9030	dobj	GATA3,analyzed
R6951	T9032	T9031	cc	and,GATA3
R6952	T9033	T9034	compound	FOXP3,expression
R6953	T9034	T9031	conj	expression,GATA3
R6954	T9035	T9030	punct	.,analyzed
R6955	T9036	T9038	det	The,kinetic
R6956	T9037	T9038	compound	expression,kinetic
R6957	T9038	T9043	nsubj	kinetic,exposed
R6958	T9039	T9038	prep	of,kinetic
R6959	T9040	T9042	amod	naive,cells
R6960	T9041	T9042	compound	T,cells
R6961	T9042	T9039	pobj	cells,of
R6962	T9043	T9048	csubj	exposed,demonstrated
R6963	T9044	T9043	prep	to,exposed
R6964	T9045	T9044	pobj	IL-4,to
R6965	T9046	T9045	cc	and,IL-4
R6966	T9047	T9045	conj	TGF-β,IL-4
R6967	T9048	T9048	ROOT	demonstrated,demonstrated
R6968	T9049	T9055	mark	that,found
R6969	T9050	T9055	nsubjpass	GATA3,found
R6970	T9051	T9050	cc	and,GATA3
R6971	T9052	T9050	conj	FOXP3,GATA3
R6972	T9053	T9055	auxpass	are,found
R6973	T9054	T9055	advmod	initially,found
R6974	T9055	T9048	ccomp	found,demonstrated
R6975	T9056	T9055	prep	in,found
R6976	T9057	T9058	amod	separate,populations
R6977	T9058	T9056	pobj	populations,in
R6978	T9059	T9060	punct	(,day
R6979	T9060	T9055	npadvmod	day,found
R6980	T9061	T9060	nummod	2,day
R6981	T9062	T9060	punct	),day
R6982	T9063	T9055	punct	",",found
R6983	T9064	T9055	cc	but,found
R6984	T9065	T9066	advmod	transiently,co-express
R6985	T9066	T9068	nummod	co-express,factors
R6986	T9067	T9068	det	both,factors
R6987	T9068	T9048	dobj	factors,demonstrated
R6988	T9069	T9068	punct	(,factors
R6989	T9070	T9068	appos	days,factors
R6990	T9071	T9070	nummod	4,days
R6991	T9072	T9070	appos	8,days
R6992	T9073	T9070	punct	),days
R6993	T9074	T9068	punct	",",factors
R6994	T9075	T9087	prep	before,day
R6995	T9076	T9075	pcomp	establishing,before
R6996	T9077	T9078	amod	separate,populations
R6997	T9078	T9076	dobj	populations,establishing
R6998	T9079	T9076	prep	at,establishing
R6999	T9080	T9081	det	the,end
R7000	T9081	T9079	pobj	end,at
R7001	T9082	T9081	prep	of,end
R7002	T9083	T9085	det	the,process
R7003	T9084	T9085	compound	differentiation,process
R7004	T9085	T9082	pobj	process,of
R7005	T9086	T9087	punct	(,day
R7006	T9087	T9068	appos	day,factors
R7007	T9088	T9087	nummod	10,day
R7008	T9089	T9068	punct	;,factors
R7009	T9090	T9091	compound	Figure,6C
R7010	T9091	T9068	appos	6C,factors
R7011	T9092	T9068	punct	),factors
R7012	T9093	T9048	punct	",",demonstrated
R7013	T9094	T9048	advcl	suggesting,demonstrated
R7014	T9095	T9097	mark	that,inhibits
R7015	T9096	T9097	nsubj	GATA3,inhibits
R7016	T9097	T9094	ccomp	inhibits,suggesting
R7017	T9098	T9099	det	the,development
R7018	T9099	T9097	dobj	development,inhibits
R7019	T9100	T9099	prep	of,development
R7020	T9101	T9102	compound	iTreg,cells
R7021	T9102	T9100	pobj	cells,of
R7022	T9103	T9097	prep	by,inhibits
R7023	T9104	T9103	pcomp	repressing,by
R7024	T9105	T9104	dobj	FOXP3,repressing
R7025	T9106	T9048	punct	.,demonstrated
R7026	T9107	T9108	det	These,results
R7027	T9108	T9109	nsubj	results,showed
R7028	T9109	T9109	ROOT	showed,showed
R7029	T9110	T9129	mark	that,acting
R7030	T9111	T9112	compound	IL-4,acts
R7031	T9112	T9129	nsubj	acts,acting
R7032	T9113	T9112	prep	in,acts
R7033	T9114	T9113	pobj	vitro,in
R7034	T9115	T9112	prep	as,acts
R7035	T9116	T9117	det	an,inhibitor
R7036	T9117	T9115	pobj	inhibitor,as
R7037	T9118	T9117	prep	of,inhibitor
R7038	T9119	T9120	nummod	FOXP3,expression
R7039	T9120	T9118	pobj	expression,of
R7040	T9121	T9112	punct	",",acts
R7041	T9122	T9112	prep	without,acts
R7042	T9123	T9122	pcomp	interfering,without
R7043	T9124	T9123	prep	with,interfering
R7044	T9125	T9126	amod	TGF-β,signaling
R7045	T9126	T9124	pobj	signaling,with
R7046	T9127	T9126	punct	",",signaling
R7047	T9128	T9129	advmod	probably,acting
R7048	T9129	T9109	ccomp	acting,showed
R7049	T9130	T9129	prep	at,acting
R7050	T9131	T9132	det	the,level
R7051	T9132	T9130	pobj	level,at
R7052	T9133	T9132	prep	of,level
R7053	T9134	T9135	compound	transcription,factors
R7054	T9135	T9133	pobj	factors,of
R7055	T9136	T9129	punct	",",acting
R7056	T9137	T9129	cc	and,acting
R7057	T9138	T9139	advmod	possibly,by
R7058	T9139	T9129	conj	by,acting
R7059	T9140	T9142	det	a,mechanism
R7060	T9141	T9142	amod	GATA3-dependent,mechanism
R7061	T9142	T9139	pobj	mechanism,by
R7062	T9143	T9109	punct	.,showed
R19297	T26012	T26013	nsubj	IL-4,Inhibits
R19298	T26013	T26013	ROOT	Inhibits,Inhibits
R19299	T26014	T26013	dobj	TGF-β,Inhibits
R19300	T26015	T26017	compound	Mediated,Commitment
R19301	T26016	T26017	compound	iTreg,Commitment
R19302	T26017	T26018	compound	Commitment,CFSE-labeled
R19303	T26018	T26021	compound	CFSE-labeled,CD45RA
R19304	T26019	T26021	compound	CD4,CD45RA
R19305	T26020	T26021	compound	+,CD45RA
R19306	T26021	T26014	appos	CD45RA,TGF-β
R19307	T26022	T26023	amod	+,cells
R19308	T26023	T26025	nsubjpass	cells,activated
R19309	T26024	T26025	auxpass	were,activated
R19310	T26025	T26013	advcl	activated,Inhibits
R19311	T26026	T26025	prep	with,activated
R19312	T26027	T26030	amod	plate-bound,CD28
R19313	T26028	T26029	amod	anti-CD3,/
R19314	T26029	T26030	compound	/,CD28
R19315	T26030	T26026	pobj	CD28,with
R19316	T26031	T26030	punct	",",CD28
R19317	T26032	T26030	conj	TGF-β,CD28
R19318	T26033	T26032	punct	",",TGF-β
R19319	T26034	T26032	cc	and,TGF-β
R19320	T26035	T26032	conj	IL-4,TGF-β
R19321	T26036	T26025	punct	",",activated
R19322	T26037	T26038	mark	as,indicated
R19323	T26038	T26025	advcl	indicated,activated
R19324	T26039	T26013	punct	.,Inhibits
R19325	T26040	T26046	mark	After,analyzed
R19326	T26041	T26046	nsubjpass	5,analyzed
R19327	T26042	T26041	advmod	d,5
R19328	T26043	T26046	punct	",",analyzed
R19329	T26044	T26046	nsubjpass	cells,analyzed
R19330	T26045	T26046	auxpass	were,analyzed
R19331	T26046	T26060	advcl	analyzed,shown
R19332	T26047	T26046	agent	by,analyzed
R19333	T26048	T26049	compound	flow,cytometry
R19334	T26049	T26047	pobj	cytometry,by
R19335	T26050	T26051	punct	(,A
R19336	T26051	T26049	parataxis	A,cytometry
R19337	T26052	T26051	punct	),A
R19338	T26053	T26049	cc	and,cytometry
R19339	T26054	T26060	nsubjpass	results,shown
R19340	T26055	T26054	prep	of,results
R19341	T26056	T26058	nummod	six,experiments
R19342	T26057	T26058	amod	independent,experiments
R19343	T26058	T26055	pobj	experiments,of
R19344	T26059	T26060	auxpass	are,shown
R19345	T26060	T26060	ROOT	shown,shown
R19346	T26061	T26060	prep	in,shown
R19347	T26062	T26064	det	the,graph
R19348	T26063	T26064	compound	bar,graph
R19349	T26064	T26061	pobj	graph,in
R19350	T26065	T26064	prep	below,graph
R19351	T26066	T26067	punct	(,B
R19352	T26067	T26065	pobj	B,below
R19353	T26068	T26067	punct	),B
R19354	T26069	T26060	punct	.,shown
R19355	T26070	T26071	compound	Statistical,significance
R19356	T26071	T26079	nsubjpass	significance,indicated
R19357	T26072	T26074	punct	(,Anova
R19358	T26073	T26074	amod	one-way,Anova
R19359	T26074	T26071	appos	Anova,significance
R19360	T26075	T26074	punct	",",Anova
R19361	T26076	T26074	appos	Newman-Keuls,Anova
R19362	T26077	T26074	punct	),Anova
R19363	T26078	T26079	auxpass	is,indicated
R19364	T26079	T26079	ROOT	indicated,indicated
R19365	T26080	T26079	agent	by,indicated
R19366	T26081	T26080	pobj	asterisks,by
R19367	T26082	T26086	punct	(,0.01
R19368	T26083	T26086	punct	**,0.01
R19369	T26084	T26086	amod	p,0.01
R19370	T26085	T26086	compound	≤,0.01
R19371	T26086	T26081	appos	0.01,asterisks
R19372	T26087	T26086	punct	",",0.01
R19373	T26088	T26090	dep	***,≤
R19374	T26089	T26090	dep	p,≤
R19375	T26090	T26086	dep	≤,0.01
R19376	T26091	T26090	pobj	0.001,≤
R19377	T26092	T26086	punct	),0.01
R19378	T26093	T26079	punct	.,indicated
R19379	T26094	T26095	punct	(,C
R19380	T26095	T26098	nmod	C,analysis
R19381	T26096	T26095	punct	),C
R19382	T26097	T26098	compound	Kinetic,analysis
R19383	T26098	T26106	nsubjpass	analysis,shown
R19384	T26099	T26098	prep	of,analysis
R19385	T26100	T26101	compound	intracellular,GATA3
R19386	T26101	T26099	pobj	GATA3,of
R19387	T26102	T26101	cc	and,GATA3
R19388	T26103	T26101	conj	FOXP3,GATA3
R19389	T26104	T26098	advmod	staining,analysis
R19390	T26105	T26106	auxpass	is,shown
R19391	T26106	T26106	ROOT	shown,shown
R19392	T26107	T26106	prep	in,shown
R19393	T26108	T26109	compound	panel,C
R19394	T26109	T26107	pobj	C,in
R19395	T26110	T26106	prep	following,shown
R19396	T26111	T26110	pobj	exposure,following
R19397	T26112	T26111	prep	of,exposure
R19398	T26113	T26115	compound	CD4,CD45RA
R19399	T26114	T26115	compound	+,CD45RA
R19400	T26115	T26112	pobj	CD45RA,of
R19401	T26116	T26118	amod	+,cells
R19402	T26117	T26118	compound	T,cells
R19403	T26118	T26111	conj	cells,exposure
R19404	T26119	T26120	aux	to,anti-CD3
R19405	T26120	T26118	relcl	anti-CD3,cells
R19406	T26121	T26120	dobj	/,anti-CD3
R19407	T26122	T26121	nummod	28,/
R19408	T26123	T26121	punct	",",/
R19409	T26124	T26121	conj	IL-4,/
R19410	T26125	T26124	cc	and,IL-4
R19411	T26126	T26124	conj	TGF-β,IL-4
R19412	T26127	T26106	punct	.,shown
R19413	T26128	T26129	nsubj	Data,are
R19414	T26129	T26129	ROOT	are,are
R19415	T26130	T26129	attr	representative,are
R19416	T26131	T26130	prep	of,representative
R19417	T26132	T26134	nummod	three,experiments
R19418	T26133	T26134	amod	independent,experiments
R19419	T26134	T26131	pobj	experiments,of
R19420	T26135	T26129	punct	.,are
R6777	T8858	T8862	nsubj	IL-4,promote
R6778	T8859	T8862	aux	did,promote
R6779	T8860	T8862	neg	not,promote
R6780	T8861	T8862	advmod	differentially,promote
R6851	T8932	T8926	punct	",",0
R6852	T8933	T8926	cc	and,0
R6853	T8934	T8937	det	the,cells
R6854	T8935	T8937	nummod	FOXP3,cells
R6855	T8936	T8937	compound	+,cells
R6856	T8937	T8940	nsubjpass	cells,confined
R6857	T8938	T8940	auxpass	were,confined
R6858	T8939	T8940	neg	not,confined
R6859	T8940	T8896	conj	confined,caused
R6860	T8941	T8940	prep	to,confined
R6930	T9011	T9009	punct	.,nonoverlapping
R6931	T9012	T9015	mark	Since,known
R6932	T9013	T9015	nsubjpass	FOXP3,known
R6933	T9014	T9015	auxpass	is,known
R6934	T9015	T9030	advcl	known,analyzed
R6935	T9016	T9017	aux	to,act

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T8273	306-312	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T8274	557-563	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T8275	458-471	http://purl.obolibrary.org/obo/GO_0051301	denotes	cell division
T8276	552-563	http://purl.obolibrary.org/obo/GO_0016049	denotes	cell growth
T8277	2424-2435	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T8278	2585-2594	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T8279	2628-2641	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T9216	73-77	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T9217	123-127	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T9218	289-293	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T9219	516-520	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T9220	1104-1108	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T9221	1751-1755	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T9222	1874-1878	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T9223	2131-2135	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T9224	2498-2502	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T26154	1120-1124	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T26155	1255-1259	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T26156	1659-1663	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T26157	1655-1661	http://purl.obolibrary.org/obo/GO_0032003	denotes	28, IL

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T9225	197-202	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9226	226-231	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9227	372-377	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9228	430-435	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9229	817-822	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9230	868-873	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9231	910-915	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9232	956-961	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9233	1004-1009	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9234	1033-1038	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9235	1074-1079	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9236	1815-1820	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9237	1889-1894	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9238	1920-1925	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9239	2114-2119	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9240	2445-2450	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T26158	1191-1196	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T26159	1286-1291	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T26160	1637-1642	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T26161	1542-1555	http://purl.obolibrary.org/obo/GO_0005622	denotes	intracellular

sentences

Id	Subject	Object	Predicate	Lexical cue
T8261	0-43	Sentence	denotes	The Role of TGF-β in T Cell Differentiation
T8262	44-271	Sentence	denotes	Although TGF-β–reduced CD25, IL-4 expression, and CD25 expression (Figure 6B), IL-4 significantly inhibited TGF-β–mediated induction of FOXP3 in naive T cells driven toward FOXP3+ T cells, as shown by FACS analysis (Figure 6A).
T8263	272-436	Sentence	denotes	It is known that IL-4 is a potent growth factor and may therefore favor the proliferation of FOXP3– cells and thus decrease the relative percentage of FOXP3+ cells.
T8264	437-594	Sentence	denotes	However, analysis of cell division kinetics by CFSE-labeling demonstrated that IL-4 did not differentially promote cell growth of FOXP3+ over that of FOXP3–.
T8265	595-672	Sentence	denotes	In fact both populations showed similarly enhanced proliferation (Figure 6A).
T8266	673-962	Sentence	denotes	Furthermore the TGF-β–mediated induction of FOXP3 expression was not caused by overgrowth of a CD25–FOXP3+ minority, since the number of FOXP3+ cells was low/absent in the purified CD4+CD45RA+ T cells (between 0% and 1%), and the FOXP3+ cells were not confined to the highly divided cells.
T8267	963-1109	Sentence	denotes	CD25 was down-regulated in TGF-β–treated cells compare to activated T cells, which was even more pronounced in cells cultured with TGF-β and IL-4.
T8268	1735-1833	Sentence	denotes	The addition of IL-4 to iTreg-driving conditions decreased the number of FOXP3+ cells (Figure 6B).
T8269	1834-1957	Sentence	denotes	In line with the previous findings, the IL-4–producing cells and the FOXP3 expressing cells are nonoverlapping populations.
T8270	1958-2079	Sentence	denotes	Since FOXP3 is known to act as a repressor of cytokine expression [20], we therefore analyzed GATA3 and FOXP3 expression.
T8271	2080-2471	Sentence	denotes	The expression kinetic of naive T cells exposed to IL-4 and TGF-β demonstrated that GATA3 and FOXP3 are initially found in separate populations (day 2), but transiently co-express both factors (days 4–8), before establishing separate populations at the end of the differentiation process (day 10; Figure 6C), suggesting that GATA3 inhibits the development of iTreg cells by repressing FOXP3.
T8272	2472-2695	Sentence	denotes	These results showed that IL-4 acts in vitro as an inhibitor of FOXP3 expression, without interfering with TGF-β signaling, probably acting at the level of transcription factors, and possibly by a GATA3-dependent mechanism.
T25857	1120-1165	Sentence	denotes	IL-4 Inhibits TGF-β–Mediated iTreg Commitment
T25858	1166-1274	Sentence	denotes	CFSE-labeled CD4+CD45RA+ cells were activated with plate-bound anti-CD3/CD28, TGF-β, and IL-4, as indicated.
T25859	1275-1408	Sentence	denotes	After 5 d, cells were analyzed by flow cytometry (A) and results of six independent experiments are shown in the bar graph below (B).
T25860	1409-1674	Sentence	denotes	Statistical significance (one-way Anova, Newman-Keuls) is indicated by asterisks (p ≤ 0.01, *p ≤ 0.001). (C) Kinetic analysis of intracellular GATA3 and FOXP3 staining is shown in panel C following exposure of CD4+CD45RA+ T cells to anti-CD3/28, IL-4 and TGF-β.
T25861	1675-1732	Sentence	denotes	Data are representative of three independent experiments.
T134	0-43	Sentence	denotes	The Role of TGF-β in T Cell Differentiation
T135	44-271	Sentence	denotes	Although TGF-β–reduced CD25, IL-4 expression, and CD25 expression (Figure 6B), IL-4 significantly inhibited TGF-β–mediated induction of FOXP3 in naive T cells driven toward FOXP3+ T cells, as shown by FACS analysis (Figure 6A).
T136	272-436	Sentence	denotes	It is known that IL-4 is a potent growth factor and may therefore favor the proliferation of FOXP3– cells and thus decrease the relative percentage of FOXP3+ cells.
T137	437-594	Sentence	denotes	However, analysis of cell division kinetics by CFSE-labeling demonstrated that IL-4 did not differentially promote cell growth of FOXP3+ over that of FOXP3–.
T138	595-672	Sentence	denotes	In fact both populations showed similarly enhanced proliferation (Figure 6A).
T139	673-962	Sentence	denotes	Furthermore the TGF-β–mediated induction of FOXP3 expression was not caused by overgrowth of a CD25–FOXP3+ minority, since the number of FOXP3+ cells was low/absent in the purified CD4+CD45RA+ T cells (between 0% and 1%), and the FOXP3+ cells were not confined to the highly divided cells.
T140	963-1109	Sentence	denotes	CD25 was down-regulated in TGF-β–treated cells compare to activated T cells, which was even more pronounced in cells cultured with TGF-β and IL-4.
T141	1110-1165	Sentence	denotes	Figure 6 IL-4 Inhibits TGF-β–Mediated iTreg Commitment
T142	1166-1274	Sentence	denotes	CFSE-labeled CD4+CD45RA+ cells were activated with plate-bound anti-CD3/CD28, TGF-β, and IL-4, as indicated.
T143	1275-1408	Sentence	denotes	After 5 d, cells were analyzed by flow cytometry (A) and results of six independent experiments are shown in the bar graph below (B).
T144	1409-1674	Sentence	denotes	Statistical significance (one-way Anova, Newman-Keuls) is indicated by asterisks (p ≤ 0.01, *p ≤ 0.001). (C) Kinetic analysis of intracellular GATA3 and FOXP3 staining is shown in panel C following exposure of CD4+CD45RA+ T cells to anti-CD3/28, IL-4 and TGF-β.
T145	1675-1732	Sentence	denotes	Data are representative of three independent experiments.
T146	1735-1833	Sentence	denotes	The addition of IL-4 to iTreg-driving conditions decreased the number of FOXP3+ cells (Figure 6B).
T147	1834-1957	Sentence	denotes	In line with the previous findings, the IL-4–producing cells and the FOXP3 expressing cells are nonoverlapping populations.
T148	1958-2079	Sentence	denotes	Since FOXP3 is known to act as a repressor of cytokine expression [20], we therefore analyzed GATA3 and FOXP3 expression.
T149	2080-2471	Sentence	denotes	The expression kinetic of naive T cells exposed to IL-4 and TGF-β demonstrated that GATA3 and FOXP3 are initially found in separate populations (day 2), but transiently co-express both factors (days 4–8), before establishing separate populations at the end of the differentiation process (day 10; Figure 6C), suggesting that GATA3 inhibits the development of iTreg cells by repressing FOXP3.
T150	2472-2695	Sentence	denotes	These results showed that IL-4 acts in vitro as an inhibitor of FOXP3 expression, without interfering with TGF-β signaling, probably acting at the level of transcription factors, and possibly by a GATA3-dependent mechanism.

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T9435	12-17	Protein	denotes	TGF-β
T9436	53-58	Protein	denotes	TGF-β
T9437	59-66	Negative_regulation	denotes	reduced
T9438	59-66	Negative_regulation	denotes	reduced
T9439	59-66	Negative_regulation	denotes	reduced
T9440	67-71	Protein	denotes	CD25
T9441	73-77	Protein	denotes	IL-4
T9442	78-88	Gene_expression	denotes	expression
T9443	78-88	Gene_expression	denotes	expression
T9444	94-98	Protein	denotes	CD25
T9445	99-109	Gene_expression	denotes	expression
T9446	123-127	Protein	denotes	IL-4
T9447	142-151	Negative_regulation	denotes	inhibited
T9448	152-157	Protein	denotes	TGF-β
T9449	167-176	Positive_regulation	denotes	induction
T9450	180-185	Protein	denotes	FOXP3
T9451	217-222	Protein	denotes	FOXP3
T9452	289-293	Protein	denotes	IL-4
T9453	365-370	Protein	denotes	FOXP3
T9454	423-428	Protein	denotes	FOXP3
T9455	516-520	Protein	denotes	IL-4
T9456	567-572	Protein	denotes	FOXP3
T9457	587-592	Protein	denotes	FOXP3
T9458	689-694	Protein	denotes	TGF-β
T9459	704-713	Positive_regulation	denotes	induction
T9460	717-722	Protein	denotes	FOXP3
T9461	723-733	Gene_expression	denotes	expression
T9462	742-748	Positive_regulation	denotes	caused	true
T9463	768-772	Protein	denotes	CD25
T9464	773-778	Protein	denotes	FOXP3
T9465	810-815	Protein	denotes	FOXP3
T9466	854-857	Protein	denotes	CD4
T9467	858-864	Protein	denotes	CD45RA
T9468	903-908	Protein	denotes	FOXP3
T9469	963-967	Protein	denotes	CD25
T9470	972-986	Negative_regulation	denotes	down-regulated
T9471	990-995	Protein	denotes	TGF-β
T9472	1060-1070	Positive_regulation	denotes	pronounced
T9473	1094-1099	Protein	denotes	TGF-β
T9474	1104-1108	Protein	denotes	IL-4
T9475	1751-1755	Protein	denotes	IL-4
T9476	1808-1813	Protein	denotes	FOXP3
T9477	1874-1878	Protein	denotes	IL-4
T9478	1879-1888	Gene_expression	denotes	producing
T9479	1903-1908	Protein	denotes	FOXP3
T9480	1909-1919	Gene_expression	denotes	expressing
T9481	1964-1969	Protein	denotes	FOXP3
T9482	2052-2057	Protein	denotes	GATA3
T9483	2062-2067	Protein	denotes	FOXP3
T9484	2068-2078	Gene_expression	denotes	expression		true
T9485	2068-2078	Gene_expression	denotes	expression		true
T9486	2131-2135	Protein	denotes	IL-4
T9487	2140-2145	Protein	denotes	TGF-β
T9488	2146-2158	Positive_regulation	denotes	demonstrated
T9489	2146-2158	Positive_regulation	denotes	demonstrated
T9490	2146-2158	Positive_regulation	denotes	demonstrated
T9491	2146-2158	Positive_regulation	denotes	demonstrated
T9492	2164-2169	Protein	denotes	GATA3
T9493	2174-2179	Protein	denotes	FOXP3
T9494	2249-2259	Gene_expression	denotes	co-express
T9495	2249-2259	Gene_expression	denotes	co-express
T9496	2405-2410	Protein	denotes	GATA3
T9497	2454-2464	Negative_regulation	denotes	repressing		true
T9498	2465-2470	Protein	denotes	FOXP3
T9499	2498-2502	Protein	denotes	IL-4
T9500	2503-2532	Negative_regulation	denotes	acts in vitro as an inhibitor
T9501	2536-2541	Protein	denotes	FOXP3
T9502	2542-2552	Gene_expression	denotes	expression
T9503	2579-2584	Protein	denotes	TGF-β
T9504	2605-2611	Positive_regulation	denotes	acting		true
T9505	2669-2674	Protein	denotes	GATA3
T9506	2675-2684	Regulation	denotes	dependent		true
T26231	1120-1124	Protein	denotes	IL-4
T26232	1134-1139	Protein	denotes	TGF-β
T26233	1179-1182	Protein	denotes	CD4
T26234	1183-1189	Protein	denotes	CD45RA
T26235	1234-1237	Protein	denotes	CD3
T26236	1238-1242	Protein	denotes	CD28
T26237	1244-1249	Protein	denotes	TGF-β
T26238	1255-1259	Protein	denotes	IL-4
T26239	1556-1561	Protein	denotes	GATA3
T26240	1566-1571	Protein	denotes	FOXP3
T26241	1572-1580	Gene_expression	denotes	staining		true
T26242	1572-1580	Gene_expression	denotes	staining		true
T26243	1623-1626	Protein	denotes	CD4
T26244	1627-1633	Protein	denotes	CD45RA
T26245	1651-1654	Protein	denotes	CD3
T26246	1655-1657	Protein	denotes	28
T26247	1659-1663	Protein	denotes	IL-4
T26248	1668-1673	Protein	denotes	TGF-β
R7207	T9436	T9439	causeOf	TGF-β,reduced
R7208	T9436	T9437	causeOf	TGF-β,reduced
R7209	T9436	T9438	causeOf	TGF-β,reduced
R7210	T9440	T9442	themeOf	CD25,expression
R7211	T9441	T9443	themeOf	IL-4,expression
R7212	T9442	T9437	themeOf	expression,reduced
R7213	T9443	T9438	themeOf	expression,reduced
R7214	T9444	T9445	themeOf	CD25,expression
R7215	T9445	T9439	themeOf	expression,reduced
R7216	T9446	T9447	causeOf	IL-4,inhibited
R7217	T9448	T9449	causeOf	TGF-β,induction
R7218	T9449	T9447	themeOf	induction,inhibited
R7219	T9450	T9449	themeOf	FOXP3,induction
R7220	T9458	T9459	causeOf	TGF-β,induction
R7221	T9459	T9462	themeOf	induction,caused
R7222	T9460	T9461	themeOf	FOXP3,expression
R7223	T9461	T9459	themeOf	expression,induction
R7224	T9469	T9470	themeOf	CD25,down-regulated
R7225	T9470	T9472	themeOf	down-regulated,pronounced
R7226	T9471	T9470	causeOf	TGF-β,down-regulated
R7227	T9474	T9472	causeOf	IL-4,pronounced
R7228	T9477	T9478	themeOf	IL-4,producing
R7229	T9479	T9480	themeOf	FOXP3,expressing
R7230	T9482	T9484	themeOf	GATA3,expression
R7231	T9483	T9485	themeOf	FOXP3,expression
R7232	T9486	T9488	causeOf	IL-4,demonstrated
R7233	T9486	T9490	causeOf	IL-4,demonstrated
R7234	T9487	T9489	causeOf	TGF-β,demonstrated
R7235	T9487	T9491	causeOf	TGF-β,demonstrated
R7236	T9492	T9494	themeOf	GATA3,co-express
R7237	T9493	T9495	themeOf	FOXP3,co-express
R7238	T9494	T9488	themeOf	co-express,demonstrated
R7239	T9494	T9489	themeOf	co-express,demonstrated
R7240	T9495	T9490	themeOf	co-express,demonstrated
R7241	T9495	T9491	themeOf	co-express,demonstrated
R7242	T9496	T9497	causeOf	GATA3,repressing
R7243	T9498	T9497	themeOf	FOXP3,repressing
R7244	T9499	T9500	causeOf	IL-4,acts in vitro as an inhibitor
R7245	T9499	T9506	causeOf	IL-4,dependent
R7246	T9500	T9504	themeOf	acts in vitro as an inhibitor,acting
R7247	T9501	T9502	themeOf	FOXP3,expression
R7248	T9502	T9500	themeOf	expression,acts in vitro as an inhibitor
R7249	T9505	T9506	themeOf	GATA3,dependent
R7250	T9506	T9504	causeOf	dependent,acting
R19434	T26239	T26241	themeOf	GATA3,staining
R19435	T26240	T26242	themeOf	FOXP3,staining

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T26162	1120-1124	Protein	denotes	IL-4
T26163	1134-1165	Protein	denotes	TGF-β–Mediated iTreg Commitment
T26164	1125-1133	Negative_regulation	denotes	Inhibits
T26165	1179-1182	Protein	denotes	CD4
T26166	1183-1189	Protein	denotes	CD45RA
T26167	1234-1237	Protein	denotes	CD3
T26168	1238-1242	Protein	denotes	CD28
T26169	1244-1249	Protein	denotes	TGF-β
T26170	1255-1259	Protein	denotes	IL-4
T26171	1556-1561	Protein	denotes	GATA3
T26172	1566-1571	Protein	denotes	FOXP3
T26173	1623-1626	Protein	denotes	CD4
T26174	1627-1633	Protein	denotes	CD45RA
T26175	1659-1663	Protein	denotes	IL-4
T26176	1668-1673	Protein	denotes	TGF-β
T26177	1572-1580	Gene_expression	denotes	staining
T26178	1572-1580	Gene_expression	denotes	staining
R19423	T26162	T26164	causeOf	IL-4,Inhibits
R19424	T26163	T26164	themeOf	TGF-β–Mediated iTreg Commitment,Inhibits
R19425	T26171	T26177	themeOf	GATA3,staining
R19426	T26172	T26178	themeOf	FOXP3,staining

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T8280	59-66	Negative_regulation	denotes	reduced
T8281	723-733	Gene_expression	denotes	expression
T8282	742-748	Positive_regulation	denotes	caused	true
T8283	972-986	Negative_regulation	denotes	down-regulated
T8284	1060-1070	Positive_regulation	denotes	pronounced
T8285	1879-1888	Gene_expression	denotes	producing
T8286	1909-1919	Gene_expression	denotes	expressing
T8287	2068-2078	Gene_expression	denotes	expression		true
T8288	2068-2078	Gene_expression	denotes	expression		true
T8289	2146-2158	Positive_regulation	denotes	demonstrated
T8290	2249-2259	Gene_expression	denotes	co-express
T8291	78-88	Gene_expression	denotes	expression
T8292	2146-2158	Positive_regulation	denotes	demonstrated
T8293	2146-2158	Positive_regulation	denotes	demonstrated
T8294	2249-2259	Gene_expression	denotes	co-express
T8295	2146-2158	Positive_regulation	denotes	demonstrated
T8296	2454-2464	Negative_regulation	denotes	repressing		true
T8339	2405-2410	Protein	denotes	GATA3
T8340	73-77	Protein	denotes	IL-4
T8341	2465-2470	Protein	denotes	FOXP3
T8342	2498-2502	Protein	denotes	IL-4
T8343	2536-2541	Protein	denotes	FOXP3
T8344	2579-2584	Protein	denotes	TGF-β
T8345	2669-2674	Protein	denotes	GATA3
T8346	94-98	Protein	denotes	CD25
T8347	123-127	Protein	denotes	IL-4
T8348	152-157	Protein	denotes	TGF-β
T8349	180-185	Protein	denotes	FOXP3
T8350	217-222	Protein	denotes	FOXP3
T8351	53-58	Protein	denotes	TGF-β
T25862	1572-1580	Gene_expression	denotes	staining		true
T25863	1572-1580	Gene_expression	denotes	staining		true
T25864	1120-1124	Protein	denotes	IL-4
T25865	1566-1571	Protein	denotes	FOXP3
T25866	1623-1626	Protein	denotes	CD4
T25867	1627-1633	Protein	denotes	CD45RA
T25868	1651-1654	Protein	denotes	CD3
T25869	1655-1657	Protein	denotes	28
T25870	1659-1663	Protein	denotes	IL-4
T25871	1668-1673	Protein	denotes	TGF-β
T25872	1179-1182	Protein	denotes	CD4
T25873	1183-1189	Protein	denotes	CD45RA
T25874	1234-1237	Protein	denotes	CD3
T25875	1238-1242	Protein	denotes	CD28
T25876	1244-1249	Protein	denotes	TGF-β
T25877	1255-1259	Protein	denotes	IL-4
T25878	1556-1561	Protein	denotes	GATA3
T25879	1134-1139	Protein	denotes	TGF-β
T8297	2503-2532	Negative_regulation	denotes	acts in vitro as an inhibitor
T8298	2542-2552	Gene_expression	denotes	expression
T8299	2605-2611	Positive_regulation	denotes	acting		true
T8300	2675-2684	Regulation	denotes	dependent		true
T8301	59-66	Negative_regulation	denotes	reduced
T8302	78-88	Gene_expression	denotes	expression
T8303	59-66	Negative_regulation	denotes	reduced
T8304	99-109	Gene_expression	denotes	expression
T8305	142-151	Negative_regulation	denotes	inhibited
T8306	167-176	Positive_regulation	denotes	induction
T8307	704-713	Positive_regulation	denotes	induction
T8308	12-17	Protein	denotes	TGF-β
T8309	289-293	Protein	denotes	IL-4
T8310	365-370	Protein	denotes	FOXP3
T8311	423-428	Protein	denotes	FOXP3
T8312	516-520	Protein	denotes	IL-4
T8313	567-572	Protein	denotes	FOXP3
T8314	587-592	Protein	denotes	FOXP3
T8315	689-694	Protein	denotes	TGF-β
T8316	717-722	Protein	denotes	FOXP3
T8317	768-772	Protein	denotes	CD25
T8318	773-778	Protein	denotes	FOXP3
T8319	810-815	Protein	denotes	FOXP3
T8320	854-857	Protein	denotes	CD4
T8321	858-864	Protein	denotes	CD45RA
T8322	903-908	Protein	denotes	FOXP3
T8323	963-967	Protein	denotes	CD25
T8324	990-995	Protein	denotes	TGF-β
T8325	1094-1099	Protein	denotes	TGF-β
T8326	1104-1108	Protein	denotes	IL-4
T8327	1751-1755	Protein	denotes	IL-4
T8328	1808-1813	Protein	denotes	FOXP3
T8329	67-71	Protein	denotes	CD25
T8330	1874-1878	Protein	denotes	IL-4
T8331	1903-1908	Protein	denotes	FOXP3
T8332	1964-1969	Protein	denotes	FOXP3
T8333	2052-2057	Protein	denotes	GATA3
T8334	2062-2067	Protein	denotes	FOXP3
T8335	2131-2135	Protein	denotes	IL-4
T8336	2140-2145	Protein	denotes	TGF-β
T8337	2164-2169	Protein	denotes	GATA3
T8338	2174-2179	Protein	denotes	FOXP3
R6278	T8281	T8307	themeOf	expression,induction
R6279	T8283	T8284	themeOf	down-regulated,pronounced
R6280	T8290	T8289	themeOf	co-express,demonstrated
R6281	T8290	T8292	themeOf	co-express,demonstrated
R6282	T8291	T8280	themeOf	expression,reduced
R6283	T8294	T8293	themeOf	co-express,demonstrated
R6284	T8294	T8295	themeOf	co-express,demonstrated
R6285	T8297	T8299	themeOf	acts in vitro as an inhibitor,acting
R6286	T8298	T8297	themeOf	expression,acts in vitro as an inhibitor
R6287	T8300	T8299	causeOf	dependent,acting
R6288	T8302	T8301	themeOf	expression,reduced
R6289	T8304	T8303	themeOf	expression,reduced
R6290	T8306	T8305	themeOf	induction,inhibited
R6291	T8307	T8282	themeOf	induction,caused
R6292	T8315	T8307	causeOf	TGF-β,induction
R6293	T8316	T8281	themeOf	FOXP3,expression
R6294	T8323	T8283	themeOf	CD25,down-regulated
R6295	T8324	T8283	causeOf	TGF-β,down-regulated
R6296	T8326	T8284	causeOf	IL-4,pronounced
R6297	T8329	T8291	themeOf	CD25,expression
R6298	T8330	T8285	themeOf	IL-4,producing
R6299	T8331	T8286	themeOf	FOXP3,expressing
R6300	T8333	T8287	themeOf	GATA3,expression
R6301	T8334	T8288	themeOf	FOXP3,expression
R6302	T8335	T8289	causeOf	IL-4,demonstrated
R6303	T8335	T8293	causeOf	IL-4,demonstrated
R6304	T8336	T8292	causeOf	TGF-β,demonstrated
R6305	T8336	T8295	causeOf	TGF-β,demonstrated
R6306	T8337	T8290	themeOf	GATA3,co-express
R6307	T8338	T8294	themeOf	FOXP3,co-express
R6308	T8339	T8296	causeOf	GATA3,repressing
R6309	T8340	T8302	themeOf	IL-4,expression
R6310	T8341	T8296	themeOf	FOXP3,repressing
R6311	T8342	T8297	causeOf	IL-4,acts in vitro as an inhibitor
R6312	T8342	T8300	causeOf	IL-4,dependent
R6313	T8343	T8298	themeOf	FOXP3,expression
R6314	T8345	T8300	themeOf	GATA3,dependent
R6315	T8346	T8304	themeOf	CD25,expression
R6316	T8347	T8305	causeOf	IL-4,inhibited
R6317	T8348	T8306	causeOf	TGF-β,induction
R6318	T8349	T8306	themeOf	FOXP3,induction
R6321	T8351	T8303	causeOf	TGF-β,reduced
R6319	T8351	T8280	causeOf	TGF-β,reduced
R6320	T8351	T8301	causeOf	TGF-β,reduced
R19187	T25865	T25863	themeOf	FOXP3,staining
R19188	T25878	T25862	themeOf	GATA3,staining

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T8707	12-17	P01137	denotes	TGF-β
T8708	53-58	P01137	denotes	TGF-β
T8709	67-71	P01589	denotes	CD25
T8710	73-77	P05112	denotes	IL-4
T8711	94-98	P01589	denotes	CD25
T8712	123-127	P05112	denotes	IL-4
T8713	152-157	P01137	denotes	TGF-β
T8714	180-185	Q9BZS1	denotes	FOXP3
T8715	217-222	Q9BZS1	denotes	FOXP3
T8716	289-293	P05112	denotes	IL-4
T8717	365-370	Q9BZS1	denotes	FOXP3
T8718	400-408	Q04864	denotes	relative
T8719	423-428	Q9BZS1	denotes	FOXP3
T8720	516-520	P05112	denotes	IL-4
T8721	567-572	Q9BZS1	denotes	FOXP3
T8722	587-592	Q9BZS1	denotes	FOXP3
T8723	689-694	P01137	denotes	TGF-β
T8724	717-722	Q9BZS1	denotes	FOXP3
T8725	768-772	P01589	denotes	CD25
T8726	773-778	Q9BZS1	denotes	FOXP3
T8727	810-815	Q9BZS1	denotes	FOXP3
T8728	854-857	P01730	denotes	CD4
T8729	858-864	P08575	denotes	CD45RA
T8730	903-908	Q9BZS1	denotes	FOXP3
T8731	963-967	P01589	denotes	CD25
T8732	990-997	P01137	denotes	TGF-β–t
T8733	1094-1099	P01137	denotes	TGF-β
T8734	1104-1108	P05112	denotes	IL-4
T8735	1751-1755	P05112	denotes	IL-4
T8736	1808-1813	Q9BZS1	denotes	FOXP3
T8737	1874-1878	P05112	denotes	IL-4
T8738	1903-1908	Q9BZS1	denotes	FOXP3
T8739	1964-1969	Q9BZS1	denotes	FOXP3
T8740	2052-2057	P23771	denotes	GATA3
T8741	2062-2067	Q9BZS1	denotes	FOXP3
T8742	2131-2135	P05112	denotes	IL-4
T8743	2140-2145	P01137	denotes	TGF-β
T8744	2164-2169	P23771	denotes	GATA3
T8745	2174-2179	Q9BZS1	denotes	FOXP3
T8746	2405-2410	P23771	denotes	GATA3
T8747	2465-2470	Q9BZS1	denotes	FOXP3
T8748	2498-2502	P05112	denotes	IL-4
T8749	2536-2541	Q9BZS1	denotes	FOXP3
T8750	2579-2584	P01137	denotes	TGF-β
T8751	2669-2674	P23771	denotes	GATA3
T25986	1120-1124	P05112	denotes	IL-4
T25987	1134-1139	P01137	denotes	TGF-β
T25988	1179-1182	P01730	denotes	CD4
T25989	1183-1189	P08575	denotes	CD45RA
T25990	1234-1237	P09693	denotes	CD3
T25991	1234-1237	P20963	denotes	CD3
T25992	1234-1237	P07766	denotes	CD3
T25993	1234-1237	P04234	denotes	CD3
T25994	1238-1242	P10747	denotes	CD28
T25995	1244-1249	P01137	denotes	TGF-β
T25996	1255-1259	P05112	denotes	IL-4
T25997	1556-1561	P23771	denotes	GATA3
T25998	1566-1571	Q9BZS1	denotes	FOXP3
T25999	1623-1626	P01730	denotes	CD4
T26000	1627-1633	P08575	denotes	CD45RA
T26001	1651-1654	P07766	denotes	CD3
T26002	1651-1654	P20963	denotes	CD3
T26003	1651-1654	P04234	denotes	CD3
T26004	1651-1654	P09693	denotes	CD3
T26005	1659-1663	P05112	denotes	IL-4
T26006	1668-1673	P01137	denotes	TGF-β

test2

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T8197	12-17	Protein	denotes	TGF-β
T8198	53-58	Protein	denotes	TGF-β
T8199	59-66	Negative_regulation	denotes	reduced
T8200	67-71	Protein	denotes	CD25
T8201	73-77	Protein	denotes	IL-4
T8202	78-88	Gene_expression	denotes	expression
T8203	94-98	Protein	denotes	CD25
T8204	99-109	Gene_expression	denotes	expression
T8205	123-127	Protein	denotes	IL-4
T8206	142-151	Negative_regulation	denotes	inhibited
T8207	152-157	Protein	denotes	TGF-β	true
T8208	158-166	Positive_regulation	denotes	mediated
T8209	167-176	Positive_regulation	denotes	induction
T8210	180-185	Protein	denotes	FOXP3
T8211	217-222	Protein	denotes	FOXP3
T8212	289-293	Protein	denotes	IL-4		true
T8213	365-370	Protein	denotes	FOXP3		true
T8214	387-395	Negative_regulation	denotes	decrease
T8215	423-428	Protein	denotes	FOXP3
T8216	516-520	Protein	denotes	IL-4
T8217	567-572	Protein	denotes	FOXP3
T8218	587-592	Protein	denotes	FOXP3
T8219	689-694	Protein	denotes	TGF-β
T8220	704-713	Positive_regulation	denotes	induction		true
T8221	717-722	Protein	denotes	FOXP3
T8222	723-733	Gene_expression	denotes	expression
T8223	742-748	Positive_regulation	denotes	caused		true
T8224	768-772	Protein	denotes	CD25		true
T8225	773-778	Protein	denotes	FOXP3
T8226	810-815	Protein	denotes	FOXP3
T8227	854-857	Protein	denotes	CD4
T8228	858-864	Protein	denotes	CD45RA
T8229	903-908	Protein	denotes	FOXP3
T8230	963-967	Protein	denotes	CD25
T8231	972-986	Negative_regulation	denotes	down-regulated
T8232	990-995	Protein	denotes	TGF-β
T8233	1094-1099	Protein	denotes	TGF-β
T8234	1104-1108	Protein	denotes	IL-4
T8235	1751-1755	Protein	denotes	IL-4
T8236	1808-1813	Protein	denotes	FOXP3
T8237	1874-1878	Protein	denotes	IL-4
T8238	1879-1888	Gene_expression	denotes	producing
T8239	1903-1908	Protein	denotes	FOXP3
T8240	1909-1919	Gene_expression	denotes	expressing
T8241	1964-1969	Protein	denotes	FOXP3
T8242	2052-2057	Protein	denotes	GATA3
T8243	2062-2067	Protein	denotes	FOXP3
T8244	2068-2078	Gene_expression	denotes	expression
T8245	2131-2135	Protein	denotes	IL-4
T8246	2140-2145	Protein	denotes	TGF-β
T8247	2164-2169	Protein	denotes	GATA3
T8248	2174-2179	Protein	denotes	FOXP3
T8249	2249-2259	Gene_expression	denotes	co-express
T8250	2405-2410	Protein	denotes	GATA3
T8251	2454-2464	Negative_regulation	denotes	repressing
T8252	2465-2470	Protein	denotes	FOXP3
T8253	2498-2502	Protein	denotes	IL-4
T8254	2508-2519	Positive_regulation	denotes	in vitro as
T8255	2520-2532	Negative_regulation	denotes	an inhibitor
T8256	2536-2541	Protein	denotes	FOXP3
T8257	2542-2552	Gene_expression	denotes	expression
T8258	2562-2573	Negative_regulation	denotes	interfering
T8259	2579-2584	Protein	denotes	TGF-β
T8260	2669-2674	Protein	denotes	GATA3
T25839	1120-1124	Protein	denotes	IL-4		true
T25840	1125-1133	Negative_regulation	denotes	Inhibits		true
T25841	1134-1139	Protein	denotes	TGF-β
T25842	1179-1182	Protein	denotes	CD4
T25843	1183-1189	Protein	denotes	CD45RA
T25844	1234-1237	Protein	denotes	CD3
T25845	1238-1242	Protein	denotes	CD28
T25846	1244-1249	Protein	denotes	TGF-β
T25847	1255-1259	Protein	denotes	IL-4
T25848	1556-1561	Protein	denotes	GATA3
T25849	1566-1571	Protein	denotes	FOXP3
T25850	1572-1580	Gene_expression	denotes	staining
T25851	1623-1626	Protein	denotes	CD4
T25852	1627-1633	Protein	denotes	CD45RA
T25853	1651-1654	Protein	denotes	CD3
T25854	1655-1657	Protein	denotes	28
T25855	1659-1663	Protein	denotes	IL-4
T25856	1668-1673	Protein	denotes	TGF-β
R6247	T8198	T8199	causeOf	TGF-β,reduced
R6248	T8200	T8202	themeOf	CD25,expression
R6249	T8201	T8202	themeOf	IL-4,expression
R6250	T8202	T8199	themeOf	expression,reduced
R6251	T8203	T8204	themeOf	CD25,expression
R6252	T8204	T8199	themeOf	expression,reduced
R6253	T8205	T8206	causeOf	IL-4,inhibited
R6254	T8207	T8209	causeOf	TGF-β,induction
R6255	T8207	T8208	causeOf	TGF-β,mediated
R6256	T8209	T8206	themeOf	induction,inhibited
R6257	T8210	T8209	themeOf	FOXP3,induction
R6258	T8219	T8220	causeOf	TGF-β,induction
R6259	T8220	T8223	themeOf	induction,caused
R6260	T8221	T8222	themeOf	FOXP3,expression
R6261	T8222	T8220	themeOf	expression,induction
R6262	T8230	T8231	themeOf	CD25,down-regulated
R6263	T8232	T8231	causeOf	TGF-β,down-regulated
R6264	T8233	T8231	causeOf	TGF-β,down-regulated
R6265	T8234	T8231	causeOf	IL-4,down-regulated
R6266	T8237	T8238	themeOf	IL-4,producing
R6267	T8239	T8240	themeOf	FOXP3,expressing
R6268	T8242	T8244	themeOf	GATA3,expression
R6269	T8243	T8244	themeOf	FOXP3,expression
R6270	T8247	T8249	themeOf	GATA3,co-express
R6271	T8248	T8249	themeOf	FOXP3,co-express
R6272	T8250	T8251	causeOf	GATA3,repressing
R6273	T8250	T8249	themeOf	GATA3,co-express
R6274	T8252	T8251	themeOf	FOXP3,repressing
R6275	T8253	T8254	causeOf	IL-4,in vitro as
R6276	T8256	T8257	themeOf	FOXP3,expression
R6277	T8257	T8255	themeOf	expression,an inhibitor
R19185	T25848	T25850	themeOf	GATA3,staining
R19186	T25849	T25850	themeOf	FOXP3,staining

PMC:2222968 / 17545-20240 JSONTXT

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