PMC:2222968 / 13785-17546 JSON TXT

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2_test

Id	Subject	Object	Predicate	Lexical cue
18162042-16467870-84705017	621-622	16467870	denotes	3
18162042-16484453-84705018	1677-1679	16484453	denotes	19
T69733	621-622	16467870	denotes	3
T89214	1677-1679	16484453	denotes	19

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T6489	0-4	NN	denotes	IL-4
T6490	5-13	VB	denotes	Inhibits
T6491	14-28	JJ	denotes	TGF-β-Mediated
T6492	29-34	NN	denotes	iTreg
T6493	35-45	NNP	denotes	Commitment
T6494	46-50	NN	denotes	IL-4
T6495	51-58	VB	denotes	induces
T6496	59-74	NN	denotes	differentiation
T6497	75-77	IN	denotes	of
T6498	78-83	JJ	denotes	naive
T6499	84-85	NN	denotes	T
T6500	86-91	NN	denotes	cells
T6501	91-92	-COMMA-	denotes	,
T6502	93-97	IN	denotes	upon
T6503	98-105	NN	denotes	antigen
T6504	106-115	NN	denotes	encounter
T6505	115-116	-COMMA-	denotes	,
T6506	117-121	IN	denotes	into
T6507	122-125	DT	denotes	the
T6508	126-129	NN	denotes	Th2
T6509	130-134	NN	denotes	cell
T6510	135-142	NN	denotes	lineage
T6511	144-146	PRP	denotes	We
T6512	147-156	RB	denotes	therefore
T6513	157-162	VB	denotes	asked
T6514	163-170	IN	denotes	whether
T6515	171-175	NN	denotes	IL-4
T6516	176-178	VB	denotes	is
T6517	179-183	JJ	denotes	able
T6518	184-186	TO	denotes	to
T6519	187-194	VB	denotes	inhibit
T6520	195-200	NN	denotes	TGF-β
T6521	201-210	NN	denotes	induction
T6522	211-213	IN	denotes	of
T6523	214-219	NN	denotes	FOXP3
T6524	220-226	IN	denotes	during
T6525	227-230	DT	denotes	the
T6526	231-238	NN	denotes	priming
T6527	239-241	IN	denotes	of
T6528	242-247	JJ	denotes	naive
T6529	248-249	NN	denotes	T
T6530	250-255	NN	denotes	cells
T6531	257-262	JJ	denotes	Human
T6532	263-274	JJ	denotes	CD4+CD45RA+
T6533	275-276	NN	denotes	T
T6534	277-282	NN	denotes	cells
T6535	283-287	VB	denotes	were
T6536	288-297	VB	denotes	activated
T6537	298-302	IN	denotes	with
T6538	303-314	JJ	denotes	plate-bound
T6539	315-328	NN	denotes	anti-CD3/CD28
T6540	329-331	IN	denotes	in
T6541	332-335	DT	denotes	the
T6542	336-344	NN	denotes	presence
T6543	345-347	IN	denotes	of
T6544	348-353	NN	denotes	TGF-β
T6545	354-360	CC	denotes	and/or
T6546	361-365	NN	denotes	IL-4
T6547	366-369	CC	denotes	and
T6548	370-379	VB	denotes	harvested
T6549	380-385	IN	denotes	after
T6550	386-387	CD	denotes	5
T6551	388-389	NN	denotes	d
T6552	391-395	NN	denotes	IL-4
T6553	396-407	RB	denotes	efficiently
T6554	408-417	VB	denotes	repressed
T6555	418-421	DT	denotes	the
T6556	422-436	JJ	denotes	TGF-β–mediated
T6557	437-446	NN	denotes	induction
T6558	447-449	IN	denotes	of
T6559	450-455	NN	denotes	FOXP3
T6560	456-466	NN	denotes	expression
T6561	467-468	-LRB-	denotes	(
T6562	468-474	NN	denotes	Figure
T6563	475-477	NN	denotes	5A
T6564	477-478	-RRB-	denotes	)
T6565	479-481	IN	denotes	in
T6566	482-483	DT	denotes	a
T6567	484-507	JJ	denotes	concentration-dependent
T6568	508-514	NN	denotes	manner
T6569	515-516	-LRB-	denotes	(
T6570	516-522	NN	denotes	Figure
T6571	523-525	NN	denotes	5B
T6572	525-526	-RRB-	denotes	)
T6573	528-531	JJ	denotes	Low
T6574	532-538	NN	denotes	levels
T6575	539-541	IN	denotes	of
T6576	542-547	NN	denotes	GATA3
T6577	548-552	VB	denotes	were
T6578	553-560	VB	denotes	induced
T6579	561-565	RB	denotes	also
T6580	566-568	IN	denotes	in
T6581	569-572	DT	denotes	the
T6582	573-580	NN	denotes	absence
T6583	581-583	IN	denotes	of
T6584	584-588	NN	denotes	IL-4
T6585	588-589	-COMMA-	denotes	,
T6586	590-592	IN	denotes	as
T6587	593-595	PRP	denotes	it
T6588	596-599	VB	denotes	was
T6589	600-610	RB	denotes	previously
T6590	611-619	VB	denotes	observed
T6591	620-621	-LRB-	denotes	[
T6592	621-622	CD	denotes	3
T6593	622-623	-RRB-	denotes	]
T6594	625-632	RB	denotes	However
T6595	632-633	-COMMA-	denotes	,
T6596	634-636	IN	denotes	at
T6597	637-640	JJ	denotes	low
T6598	641-654	NN	denotes	concentration
T6599	654-655	-COMMA-	denotes	,
T6600	656-660	NN	denotes	IL-4
T6601	661-664	VB	denotes	was
T6602	665-669	JJ	denotes	able
T6603	670-672	TO	denotes	to
T6604	673-683	RB	denotes	marginally
T6605	684-690	VB	denotes	induce
T6606	691-696	NN	denotes	FOXP3
T6607	697-707	NN	denotes	expression
T6608	709-711	IN	denotes	Of
T6609	712-716	NN	denotes	note
T6610	716-717	-COMMA-	denotes	,
T6611	718-723	NN	denotes	GATA3
T6612	724-727	VB	denotes	was
T6613	728-732	RB	denotes	also
T6614	733-740	VB	denotes	induced
T6615	741-743	IN	denotes	in
T6616	744-747	DT	denotes	the
T6617	748-756	NN	denotes	presence
T6618	757-759	IN	denotes	of
T6619	760-765	NN	denotes	TGF-β
T6620	766-768	IN	denotes	at
T6621	769-773	JJ	denotes	high
T6622	774-778	NN	denotes	IL-4
T6623	779-792	NN	denotes	concentration
T6624	793-794	-LRB-	denotes	(
T6625	794-800	NN	denotes	Figure
T6626	801-803	NN	denotes	5A
T6627	804-807	CC	denotes	and
T6628	808-810	NN	denotes	5B
T6629	810-811	-RRB-	denotes	)
T6630	813-816	DT	denotes	The
T6631	817-830	JJ	denotes	IL-4–mediated
T6632	831-841	NN	denotes	prevention
T6633	842-844	IN	denotes	of
T6634	845-850	NN	denotes	FOXP3
T6635	851-861	NN	denotes	expression
T6636	862-865	VB	denotes	was
T6637	866-869	RB	denotes	not
T6638	870-876	VB	denotes	caused
T6639	877-879	IN	denotes	by
T6640	880-893	NN	denotes	interferences
T6641	894-896	IN	denotes	of
T6642	897-900	DT	denotes	the
T6643	901-909	NN	denotes	receptor
T6644	910-919	NN	denotes	signaling
T6645	919-920	-COMMA-	denotes	,
T6646	921-928	IN	denotes	because
T6647	929-932	DT	denotes	the
T6648	933-948	NN	denotes	phosphorylation
T6649	949-951	IN	denotes	of
T6650	952-957	NN	denotes	SMAD2
T6651	958-960	CC	denotes	or
T6652	961-966	NN	denotes	STAT6
T6653	967-970	VB	denotes	was
T6654	971-974	RB	denotes	not
T6655	975-983	VB	denotes	affected
T6656	984-986	IN	denotes	by
T6657	987-990	DT	denotes	the
T6658	991-999	NN	denotes	addition
T6659	1000-1002	IN	denotes	of
T6660	1003-1007	NN	denotes	IL-4
T6661	1008-1014	CC	denotes	and/or
T6662	1015-1020	NN	denotes	TGF-β
T6663	1020-1021	-COMMA-	denotes	,
T6664	1022-1027	WDT	denotes	which
T6665	1028-1040	VB	denotes	demonstrates
T6666	1041-1045	IN	denotes	that
T6667	1046-1050	NN	denotes	IL-4
T6668	1051-1053	RB	denotes	as
T6669	1054-1058	RB	denotes	well
T6670	1059-1061	IN	denotes	as
T6671	1062-1067	NN	denotes	TGF-β
T6672	1068-1077	NN	denotes	signaling
T6673	1078-1082	VB	denotes	were
T6674	1083-1093	JJ	denotes	functional
T6675	1094-1099	IN	denotes	under
T6676	1100-1105	DT	denotes	these
T6677	1106-1116	NN	denotes	conditions
T6678	1117-1118	-LRB-	denotes	(
T6679	1118-1124	NN	denotes	Figure
T6680	1125-1127	NN	denotes	5C
T6681	1127-1128	-RRB-	denotes	)
T6682	1130-1140	VB	denotes	Increasing
T6683	1141-1148	NN	denotes	amounts
T6684	1149-1151	IN	denotes	of
T6685	1152-1156	NN	denotes	IL-4
T6686	1157-1165	NN	denotes	increase
T6687	1166-1179	JJ	denotes	intracellular
T6688	1180-1185	NN	denotes	GATA3
T6689	1185-1186	-COMMA-	denotes	,
T6690	1187-1194	IN	denotes	whereas
T6691	1195-1200	NN	denotes	FOXP3
T6692	1201-1210	VB	denotes	decreased
T6693	1210-1211	-COMMA-	denotes	,
T6694	1212-1217	WDT	denotes	which
T6695	1218-1220	VB	denotes	is
T6696	1221-1231	JJ	denotes	consistent
T6697	1232-1236	IN	denotes	with
T6698	1237-1240	DT	denotes	the
T6699	1241-1245	NN	denotes	mRNA
T6700	1246-1254	NN	denotes	analysis
T6701	1255-1256	-LRB-	denotes	(
T6702	1256-1262	NN	denotes	Figure
T6703	1263-1265	NN	denotes	5D
T6704	1265-1266	-RRB-	denotes	)
T6705	1268-1279	RB	denotes	Furthermore
T6706	1279-1280	-COMMA-	denotes	,
T6707	1281-1290	NN	denotes	injection
T6708	1291-1293	IN	denotes	of
T6709	1294-1298	NN	denotes	IL-4
T6710	1299-1303	IN	denotes	into
T6711	1304-1313	JJ	denotes	wild-type
T6712	1314-1316	NN	denotes	B6
T6713	1317-1321	NN	denotes	mice
T6714	1322-1331	VB	denotes	decreased
T6715	1332-1335	DT	denotes	the
T6716	1336-1345	JJ	denotes	inducible
T6717	1346-1348	CC	denotes	or
T6718	1349-1356	JJ	denotes	natural
T6719	1357-1361	NN	denotes	Treg
T6720	1362-1368	NN	denotes	number
T6721	1369-1371	FW	denotes	in
T6722	1372-1376	FW	denotes	vivo
T6723	1378-1379	DT	denotes	A
T6724	1380-1391	NN	denotes	distinction
T6725	1392-1394	IN	denotes	of
T6726	1395-1398	DT	denotes	the
T6727	1399-1403	NN	denotes	Treg
T6728	1404-1411	NN	denotes	subsets
T6729	1412-1414	VB	denotes	is
T6730	1415-1418	RB	denotes	not
T6731	1419-1427	JJ	denotes	possible
T6732	1427-1428	-COMMA-	denotes	,
T6733	1429-1436	IN	denotes	because
T6734	1437-1445	RB	denotes	recently
T6735	1446-1455	VB	denotes	activated
T6736	1456-1461	NN	denotes	iTreg
T6737	1462-1467	NN	denotes	cells
T6738	1468-1472	RB	denotes	also
T6739	1473-1480	VB	denotes	express
T6740	1481-1488	NN	denotes	surface
T6741	1489-1493	NN	denotes	CD25
T6742	1495-1497	PRP	denotes	We
T6743	1498-1502	VB	denotes	used
T6744	1503-1512	NN	denotes	complexes
T6745	1513-1515	IN	denotes	of
T6746	1516-1527	JJ	denotes	recombinant
T6747	1528-1533	NN	denotes	mouse
T6748	1534-1538	NN	denotes	IL-4
T6749	1539-1540	-LRB-	denotes	(
T6750	1540-1546	NN	denotes	rmIL-4
T6751	1546-1547	-RRB-	denotes	)
T6752	1548-1552	CC	denotes	plus
T6753	1553-1562	JJ	denotes	anti-IL-4
T6754	1563-1573	JJ	denotes	monoclonal
T6755	1574-1584	NN	denotes	antibodies
T6756	1585-1586	-LRB-	denotes	(
T6757	1586-1590	NN	denotes	mAbs
T6758	1590-1591	-RRB-	denotes	)
T6759	1591-1592	-COMMA-	denotes	,
T6760	1593-1598	WDT	denotes	which
T6761	1599-1603	VB	denotes	have
T6762	1604-1608	VB	denotes	been
T6763	1609-1614	VB	denotes	shown
T6764	1615-1617	TO	denotes	to
T6765	1618-1630	RB	denotes	dramatically
T6766	1631-1639	VB	denotes	increase
T6767	1640-1643	DT	denotes	the
T6768	1644-1651	NN	denotes	potency
T6769	1652-1654	IN	denotes	of
T6770	1655-1658	DT	denotes	the
T6771	1659-1667	NN	denotes	cytokine
T6772	1668-1670	FW	denotes	in
T6773	1671-1675	FW	denotes	vivo
T6774	1676-1677	-LRB-	denotes	[
T6775	1677-1679	CD	denotes	19
T6776	1679-1680	-RRB-	denotes	]
T6777	1682-1684	IN	denotes	In
T6778	1685-1690	DT	denotes	these
T6779	1691-1695	NN	denotes	mice
T6780	1695-1696	-COMMA-	denotes	,
T6781	1697-1700	DT	denotes	the
T6782	1701-1711	NN	denotes	percentage
T6783	1712-1714	IN	denotes	of
T6784	1715-1724	JJ	denotes	CD4+CD25+
T6785	1725-1728	CC	denotes	and
T6786	1729-1735	JJ	denotes	FOXP3+
T6787	1736-1737	NN	denotes	T
T6788	1738-1743	NN	denotes	cells
T6789	1744-1756	RB	denotes	dramatically
T6790	1757-1766	VB	denotes	decreased
T6791	1767-1771	WRB	denotes	when
T6792	1772-1775	DT	denotes	the
T6793	1776-1793	JJ	denotes	antibody-cytokine
T6794	1794-1800	JJ	denotes	immune
T6795	1801-1810	NN	denotes	complexes
T6796	1811-1815	VB	denotes	were
T6797	1816-1824	VB	denotes	injected
T6798	1825-1826	-LRB-	denotes	(
T6799	1826-1832	NN	denotes	Figure
T6800	1833-1835	NN	denotes	S2
T6801	1835-1836	-RRB-	denotes	)
T6802	1838-1842	IN	denotes	Upon
T6803	1843-1857	NN	denotes	administration
T6804	1858-1860	IN	denotes	of
T6805	1861-1867	NN	denotes	rmIL-4
T6806	1868-1872	CC	denotes	plus
T6807	1873-1882	JJ	denotes	anti-IL-4
T6808	1883-1886	NN	denotes	mAb
T6809	1887-1896	NN	denotes	complexes
T6810	1896-1897	-COMMA-	denotes	,
T6811	1898-1901	DT	denotes	the
T6812	1902-1907	JJ	denotes	total
T6813	1908-1914	NN	denotes	number
T6814	1915-1917	IN	denotes	of
T6815	1918-1927	JJ	denotes	CD4+CD25+
T6816	1928-1929	NN	denotes	T
T6817	1930-1934	NN	denotes	cell
T6818	1934-1935	-COMMA-	denotes	,
T6819	1936-1938	RB	denotes	as
T6820	1939-1943	RB	denotes	well
T6821	1944-1946	IN	denotes	as
T6822	1947-1950	DT	denotes	the
T6823	1951-1957	JJ	denotes	Foxp3+
T6824	1958-1959	NN	denotes	T
T6825	1960-1965	NN	denotes	cells
T6826	1966-1976	VB	denotes	diminished
T6827	1977-1979	IN	denotes	by
T6828	1980-1984	NN	denotes	half
T6829	1985-1986	-LRB-	denotes	(
T6830	1986-1992	NN	denotes	Figure
T6831	1993-1996	NN	denotes	S2G
T6832	1997-2000	CC	denotes	and
T6833	2001-2004	NN	denotes	S2H
T6834	2004-2005	-RRB-	denotes	)
T6835	2005-2006	-COMMA-	denotes	,
T6836	2007-2017	VB	denotes	confirming
T6837	2018-2022	IN	denotes	that
T6838	2023-2026	DT	denotes	the
T6839	2027-2032	JJ	denotes	lower
T6840	2033-2043	NN	denotes	percentage
T6841	2044-2047	VB	denotes	was
T6842	2048-2051	RB	denotes	not
T6843	2052-2055	JJ	denotes	due
T6844	2056-2058	TO	denotes	to
T6845	2059-2061	DT	denotes	an
T6846	2062-2070	NN	denotes	increase
T6847	2071-2073	IN	denotes	in
T6848	2074-2077	DT	denotes	the
T6849	2078-2087	NN	denotes	CD4+CD25–
T6850	2088-2093	NN	denotes	cells
T6851	2093-2094	-COMMA-	denotes	,
T6852	2095-2098	CC	denotes	but
T6853	2099-2100	DT	denotes	a
T6854	2101-2105	JJ	denotes	real
T6855	2106-2114	NN	denotes	decrease
T6856	2115-2117	IN	denotes	of
T6857	2118-2127	JJ	denotes	CD4+CD25+
T6858	2128-2129	NN	denotes	T
T6859	2130-2135	NN	denotes	cells
T6860	2137-2139	IN	denotes	In
T6861	2140-2150	NN	denotes	conclusion
T6862	2150-2151	-COMMA-	denotes	,
T6863	2152-2156	NN	denotes	IL-4
T6864	2157-2167	RB	denotes	negatively
T6865	2168-2177	VB	denotes	regulates
T6866	2178-2181	DT	denotes	the
T6867	2182-2189	JJ	denotes	natural
T6868	2190-2192	CC	denotes	or
T6869	2193-2202	JJ	denotes	inducible
T6870	2203-2207	NN	denotes	Treg
T6871	2208-2212	NN	denotes	cell
T6872	2213-2221	NN	denotes	turnover
T6873	2222-2225	RB	denotes	not
T6874	2226-2230	RB	denotes	only
T6875	2231-2233	FW	denotes	in
T6876	2234-2239	FW	denotes	vitro
T6877	2240-2243	CC	denotes	but
T6878	2244-2248	RB	denotes	also
T6879	2249-2251	FW	denotes	in
T6880	2252-2256	FW	denotes	vivo
T6881	2258-2260	TO	denotes	To
T6882	2261-2266	VB	denotes	study
T6883	2267-2270	DT	denotes	the
T6884	2271-2278	NN	denotes	effects
T6885	2279-2281	IN	denotes	of
T6886	2282-2286	NN	denotes	IL-4
T6887	2287-2289	IN	denotes	on
T6888	2290-2306	JJ	denotes	already-existing
T6889	2307-2312	JJ	denotes	human
T6890	2313-2320	JJ	denotes	natural
T6891	2321-2323	CC	denotes	or
T6892	2324-2333	JJ	denotes	inducible
T6893	2334-2338	NN	denotes	Treg
T6894	2339-2344	NN	denotes	cells
T6895	2344-2345	-COMMA-	denotes	,
T6896	2346-2348	PRP	denotes	we
T6897	2349-2356	VB	denotes	exposed
T6898	2357-2363	VB	denotes	sorted
T6899	2364-2369	JJ	denotes	CD25+
T6900	2370-2371	NN	denotes	T
T6901	2372-2377	NN	denotes	cells
T6902	2378-2379	-LRB-	denotes	(
T6903	2379-2384	NN	denotes	nTreg
T6904	2385-2390	NN	denotes	cells
T6905	2390-2391	-RRB-	denotes	)
T6906	2392-2394	TO	denotes	to
T6907	2395-2399	NN	denotes	IL-4
T6908	2400-2403	CC	denotes	and
T6909	2404-2412	VB	denotes	analyzed
T6910	2413-2418	NN	denotes	FOXP3
T6911	2419-2429	NN	denotes	expression
T6912	2430-2433	CC	denotes	and
T6913	2434-2445	JJ	denotes	suppressive
T6914	2446-2454	NN	denotes	capacity
T6915	2456-2458	IN	denotes	In
T6916	2459-2475	JJ	denotes	already-existing
T6917	2476-2480	NN	denotes	Treg
T6918	2481-2486	NN	denotes	cells
T6919	2486-2487	-COMMA-	denotes	,
T6920	2488-2492	NN	denotes	IL-4
T6921	2493-2499	VB	denotes	failed
T6922	2500-2502	TO	denotes	to
T6923	2503-2510	VB	denotes	inhibit
T6924	2511-2516	NN	denotes	FOXP3
T6925	2517-2527	NN	denotes	expression
T6926	2528-2529	-LRB-	denotes	(
T6927	2529-2535	NN	denotes	Figure
T6928	2536-2539	NN	denotes	S3A
T6929	2539-2540	-RRB-	denotes	)
T6930	2540-2541	-COMMA-	denotes	,
T6931	2542-2545	CC	denotes	and
T6932	2546-2549	DT	denotes	the
T6933	2550-2561	JJ	denotes	suppressive
T6934	2562-2570	NN	denotes	capacity
T6935	2571-2574	VB	denotes	was
T6936	2575-2578	RB	denotes	not
T6937	2579-2586	VB	denotes	altered
T6938	2587-2588	-LRB-	denotes	(
T6939	2588-2594	NN	denotes	Figure
T6940	2595-2598	NN	denotes	S3C
T6941	2598-2599	-RRB-	denotes	)
T6942	2601-2610	RB	denotes	Similarly
T6943	2611-2623	JJ	denotes	pre-existing
T6944	2624-2629	NN	denotes	iTreg
T6945	2630-2635	NN	denotes	cells
T6946	2636-2639	VB	denotes	did
T6947	2640-2643	RB	denotes	not
T6948	2644-2652	VB	denotes	decrease
T6949	2653-2658	NN	denotes	FOXP3
T6950	2659-2669	NN	denotes	expression
T6951	2670-2674	IN	denotes	upon
T6952	2675-2679	NN	denotes	IL-4
T6953	2680-2688	NN	denotes	exposure
T6954	2689-2690	-LRB-	denotes	(
T6955	2690-2696	NN	denotes	Figure
T6956	2697-2700	NN	denotes	S3B
T6957	2700-2701	-RRB-	denotes	)
T25158	2713-2719	NN	denotes	Effect
T25159	2720-2722	IN	denotes	of
T25160	2723-2727	NN	denotes	IL-4
T25161	2728-2730	IN	denotes	on
T25162	2731-2736	NN	denotes	FOXP3
T25163	2737-2746	NN	denotes	Induction
T25164	2747-2748	-LRB-	denotes	(
T25165	2748-2749	NN	denotes	A
T25166	2749-2750	-RRB-	denotes	)
T25167	2751-2752	NN	denotes	A
T25168	2753-2764	JJ	denotes	statistical
T25169	2765-2773	NN	denotes	analysis
T25170	2774-2777	VB	denotes	was
T25171	2778-2787	VB	denotes	performed
T25172	2788-2792	IN	denotes	with
T25173	2793-2796	CD	denotes	six
T25174	2797-2803	NN	denotes	donors
T25175	2804-2806	IN	denotes	on
T25176	2807-2810	NN	denotes	day
T25177	2811-2812	CD	denotes	5
T25178	2813-2814	-LRB-	denotes	(
T25179	2814-2819	NN	denotes	TGF-β
T25180	2820-2821	-LRB-	denotes	(
T25181	2821-2823	CD	denotes	10
T25182	2824-2829	NN	denotes	ng/ml
T25183	2829-2830	-RRB-	denotes	)
T25184	2831-2834	CC	denotes	and
T25185	2835-2839	IN	denotes	with
T25186	2840-2842	CC	denotes	or
T25187	2843-2850	IN	denotes	without
T25188	2851-2855	NN	denotes	IL-4
T25189	2856-2857	-LRB-	denotes	(
T25190	2857-2860	CD	denotes	100
T25191	2861-2866	NN	denotes	ng/ml
T25192	2866-2867	-RRB-	denotes	)
T25193	2867-2868	-RRB-	denotes	)
T25194	2868-2869	-COLON-	denotes	;
T25195	2870-2875	NNP	denotes	Shown
T25196	2876-2878	VB	denotes	is
T25197	2879-2882	DT	denotes	the
T25198	2883-2887	NN	denotes	mean
T25199	2887-2888	-COMMA-	denotes	,
T25200	2889-2892	CC	denotes	and
T25201	2893-2898	NN	denotes	error
T25202	2899-2903	NN	denotes	bars
T25203	2904-2913	VB	denotes	indicated
T25204	2914-2917	DT	denotes	the
T25205	2918-2920	NN	denotes	SD
T25206	2921-2923	IN	denotes	of
T25207	2924-2927	CD	denotes	six
T25208	2928-2934	NN	denotes	donors
T25209	2936-2947	JJ	denotes	Statistical
T25210	2948-2956	NN	denotes	analysis
T25211	2957-2960	VB	denotes	was
T25212	2961-2970	VB	denotes	performed
T25213	2971-2976	VB	denotes	using
T25214	2977-2980	DT	denotes	the
T25215	2981-2988	NNP	denotes	Dunnett
T25216	2989-2993	NN	denotes	test
T25217	2995-3006	JJ	denotes	Statistical
T25218	3007-3019	NN	denotes	significance
T25219	3020-3022	VB	denotes	is
T25220	3023-3032	VB	denotes	indicated
T25221	3033-3035	IN	denotes	by
T25222	3036-3045	NN	denotes	asterisks
T25223	3046-3047	-LRB-	denotes	(
T25224	3047-3049	NN	denotes	*p
T25225	3050-3051	NN	denotes	≤
T25226	3052-3056	CD	denotes	0.05
T25227	3056-3057	-COMMA-	denotes	,
T25228	3058-3061	NN	denotes	**p
T25229	3062-3063	-COMMA-	denotes	≤
T25230	3064-3068	CD	denotes	0.01
T25231	3068-3069	-COMMA-	denotes	,
T25232	3070-3077	NNP	denotes	Dunnett
T25233	3077-3078	-RRB-	denotes	)
T25234	3080-3081	-LRB-	denotes	(
T25235	3081-3082	NN	denotes	B
T25236	3082-3083	-RRB-	denotes	)
T25237	3084-3095	JJ	denotes	CD4+CD45RA+
T25238	3096-3101	NN	denotes	cells
T25239	3102-3106	VB	denotes	were
T25240	3107-3116	VB	denotes	activated
T25241	3117-3119	IN	denotes	in
T25242	3120-3123	DT	denotes	the
T25243	3124-3132	NN	denotes	presence
T25244	3133-3135	IN	denotes	of
T25245	3136-3137	DT	denotes	a
T25246	3138-3146	JJ	denotes	constant
T25247	3147-3160	NN	denotes	concentration
T25248	3161-3163	IN	denotes	of
T25249	3164-3169	NN	denotes	TGF-β
T25250	3170-3171	-LRB-	denotes	(
T25251	3171-3172	CD	denotes	5
T25252	3173-3178	NN	denotes	ng/ml
T25253	3178-3179	-RRB-	denotes	)
T25254	3180-3184	IN	denotes	with
T25255	3185-3187	DT	denotes	an
T25256	3188-3198	VB	denotes	increasing
T25257	3199-3212	NN	denotes	concentration
T25258	3213-3215	IN	denotes	of
T25259	3216-3220	NN	denotes	IL-4
T25260	3220-3221	-COMMA-	denotes	,
T25261	3222-3224	IN	denotes	as
T25262	3225-3234	VB	denotes	indicated
T25263	3236-3241	NN	denotes	Cells
T25264	3242-3246	VB	denotes	were
T25265	3247-3256	VB	denotes	harvested
T25266	3257-3260	IN	denotes	for
T25267	3261-3265	NN	denotes	mRNA
T25268	3266-3280	NN	denotes	quantification
T25269	3281-3286	IN	denotes	after
T25270	3287-3288	CD	denotes	5
T25271	3289-3290	NN	denotes	d
T25272	3292-3293	-LRB-	denotes	(
T25273	3293-3294	NN	denotes	C
T25274	3294-3295	-RRB-	denotes	)
T25275	3296-3307	JJ	denotes	CD4+CD45RA+
T25276	3308-3313	NN	denotes	cells
T25277	3314-3318	VB	denotes	were
T25278	3319-3329	VB	denotes	stimulated
T25279	3330-3332	FW	denotes	in
T25280	3333-3338	FW	denotes	vitro
T25281	3339-3343	IN	denotes	with
T25282	3344-3355	JJ	denotes	plate-bound
T25283	3356-3369	NN	denotes	anti-CD3/CD28
T25284	3369-3370	-COMMA-	denotes	,
T25285	3371-3376	NN	denotes	TGF-β
T25286	3377-3378	-LRB-	denotes	(
T25287	3378-3385	NN	denotes	10ng/ml
T25288	3385-3386	-RRB-	denotes	)
T25289	3386-3387	-COMMA-	denotes	,
T25290	3388-3391	CC	denotes	and
T25291	3392-3396	NN	denotes	IL-4
T25292	3397-3398	-LRB-	denotes	(
T25293	3398-3401	CD	denotes	100
T25294	3402-3407	NN	denotes	ng/ml
T25295	3407-3408	-RRB-	denotes	)
T25296	3409-3411	IN	denotes	as
T25297	3412-3421	VB	denotes	indicated
T25298	3423-3428	IN	denotes	After
T25299	3429-3430	CD	denotes	1
T25300	3431-3432	NN	denotes	h
T25301	3432-3433	-COMMA-	denotes	,
T25302	3434-3438	NN	denotes	cell
T25303	3439-3446	NN	denotes	lysates
T25304	3447-3451	VB	denotes	were
T25305	3452-3460	VB	denotes	prepared
T25306	3461-3464	CC	denotes	and
T25307	3465-3473	VB	denotes	analyzed
T25308	3474-3476	IN	denotes	by
T25309	3477-3484	JJ	denotes	Western
T25310	3485-3489	NN	denotes	blot
T25311	3490-3493	IN	denotes	for
T25312	3494-3508	VB	denotes	phosphorylated
T25313	3509-3514	NN	denotes	SMAD2
T25314	3515-3518	CC	denotes	and
T25315	3519-3524	NN	denotes	STAT6
T25316	3526-3531	JJ	denotes	Total
T25317	3532-3537	NN	denotes	STAT6
T25318	3538-3541	CC	denotes	and
T25319	3542-3547	NN	denotes	GAPDH
T25320	3548-3554	VB	denotes	served
T25321	3555-3557	IN	denotes	as
T25322	3558-3566	JJ	denotes	internal
T25323	3567-3574	NN	denotes	control
T25324	3576-3577	-LRB-	denotes	(
T25325	3577-3578	NN	denotes	D
T25326	3578-3579	-RRB-	denotes	)
T25327	3580-3593	JJ	denotes	Intracellular
T25328	3594-3599	NN	denotes	GATA3
T25329	3600-3603	CC	denotes	and
T25330	3604-3609	NN	denotes	FOXP3
T25331	3610-3618	NN	denotes	staining
T25332	3619-3622	VB	denotes	are
T25333	3623-3628	VB	denotes	shown
T25334	3629-3634	IN	denotes	after
T25335	3635-3643	NN	denotes	exposure
T25336	3644-3646	IN	denotes	of
T25337	3647-3658	JJ	denotes	CD4+CD45RA+
T25338	3659-3660	NN	denotes	T
T25339	3661-3666	NN	denotes	cells
T25340	3667-3669	TO	denotes	to
T25341	3670-3674	NN	denotes	IL-4
T25342	3675-3677	IN	denotes	as
T25343	3678-3687	VB	denotes	described
T25344	3688-3691	IN	denotes	for
T25345	3692-3697	NN	denotes	panel
T25346	3698-3700	NNP	denotes	B.
T25347	3701-3705	NNP	denotes	Data
T25348	3706-3709	VB	denotes	are
T25349	3710-3724	JJ	denotes	representative
T25350	3725-3727	IN	denotes	of
T25351	3728-3733	CD	denotes	three
T25352	3734-3745	JJ	denotes	independent
T25353	3746-3757	NN	denotes	experiments
R4884	T6489	T6490	arg1Of	IL-4,Inhibits
R4885	T6493	T6490	arg2Of	Commitment,Inhibits
R4886	T6493	T6491	arg1Of	Commitment,TGF-β-Mediated
R4887	T6493	T6492	arg1Of	Commitment,iTreg
R4888	T6494	T6495	arg1Of	IL-4,induces
R4889	T6495	T6501	arg1Of	induces,","
R4890	T6495	T6502	arg1Of	induces,upon
R4891	T6495	T6505	arg1Of	induces,","
R4892	T6495	T6506	arg1Of	induces,into
R4893	T6496	T6495	arg2Of	differentiation,induces
R4895	T6496	T6497	arg1Of	differentiation,of
R4896	T6500	T6497	arg2Of	cells,of
R4900	T6500	T6498	arg1Of	cells,naive
R4902	T6500	T6499	arg1Of	cells,T
R4903	T6504	T6502	arg2Of	encounter,upon
R4907	T6504	T6503	arg1Of	encounter,antigen
R4909	T6510	T6506	arg2Of	lineage,into
R4919	T6510	T6507	arg1Of	lineage,the
R4921	T6510	T6508	arg1Of	lineage,Th2
R4926	T6510	T6509	arg1Of	lineage,cell
R4927	T6511	T6513	arg1Of	We,asked
R4929	T6513	T6512	arg1Of	asked,therefore
R4933	T6515	T6516	arg1Of	IL-4,is
R4935	T6515	T6517	arg1Of	IL-4,able
R4937	T6515	T6519	arg1Of	IL-4,inhibit
R4938	T6516	T6513	arg2Of	is,asked
R4939	T6516	T6514	arg1Of	is,whether
R4940	T6517	T6516	arg2Of	able,is
R4942	T6519	T6517	arg2Of	inhibit,able
R4943	T6519	T6518	arg1Of	inhibit,to
R4944	T6519	T6524	arg1Of	inhibit,during
R4949	T6521	T6519	arg2Of	induction,inhibit
R4953	T6521	T6520	arg1Of	induction,TGF-β
R4954	T6521	T6522	arg1Of	induction,of
R4955	T6523	T6522	arg2Of	FOXP3,of
R4956	T6526	T6524	arg2Of	priming,during
R4957	T6526	T6525	arg1Of	priming,the
R4958	T6526	T6527	arg1Of	priming,of
R4959	T6530	T6527	arg2Of	cells,of
R4960	T6547	T6535	arg2Of	and,were
R4961	T6530	T6528	arg1Of	cells,naive
R4962	T6548	T6547	arg2Of	harvested,and
R4963	T6548	T6549	arg1Of	harvested,after
R4964	T6530	T6529	arg1Of	cells,T
R4965	T6534	T6531	arg1Of	cells,Human
R4966	T6551	T6549	arg2Of	d,after
R4967	T6551	T6550	arg1Of	d,5
R4968	T6552	T6554	arg1Of	IL-4,repressed
R4969	T6534	T6532	arg1Of	cells,CD4+CD45RA+
R4970	T6554	T6553	arg1Of	repressed,efficiently
R4971	T6554	T6565	arg1Of	repressed,in
R4972	T6534	T6533	arg1Of	cells,T
R4973	T6534	T6535	arg1Of	cells,were
R4974	T6534	T6536	arg2Of	cells,activated
R4975	T6557	T6554	arg2Of	induction,repressed
R4976	T6557	T6555	arg1Of	induction,the
R4977	T6557	T6556	arg1Of	induction,TGF-β–mediated
R4978	T6557	T6558	arg1Of	induction,of
R4979	T6534	T6548	arg2Of	cells,harvested
R4980	T6536	T6537	arg1Of	activated,with
R4981	T6560	T6558	arg2Of	expression,of
R4982	T6560	T6559	arg1Of	expression,FOXP3
R4983	T6560	T6561	arg1Of	expression,(
R4984	T6563	T6561	arg2Of	5A,(
R4985	T6563	T6562	arg1Of	5A,Figure
R4986	T6536	T6540	arg1Of	activated,in
R4987	T6536	T6547	arg1Of	activated,and
R4988	T6539	T6537	arg2Of	anti-CD3/CD28,with
R4989	T6564	T6561	arg3Of	),(
R4990	T6568	T6565	arg2Of	manner,in
R4991	T6568	T6566	arg1Of	manner,a
R4992	T6568	T6567	arg1Of	manner,concentration-dependent
R4993	T6568	T6569	arg1Of	manner,(
R4994	T6571	T6569	arg2Of	5B,(
R4995	T6571	T6570	arg1Of	5B,Figure
R4996	T6539	T6538	arg1Of	anti-CD3/CD28,plate-bound
R4997	T6572	T6569	arg3Of	),(
R4998	T6542	T6540	arg2Of	presence,in
R4999	T6574	T6573	arg1Of	levels,Low
R5000	T6574	T6575	arg1Of	levels,of
R5001	T6574	T6577	arg1Of	levels,were
R5002	T6574	T6578	arg2Of	levels,induced
R5003	T6576	T6575	arg2Of	GATA3,of
R5004	T6542	T6541	arg1Of	presence,the
R5005	T6578	T6577	arg2Of	induced,were
R5006	T6578	T6579	arg1Of	induced,also
R5007	T6578	T6580	arg1Of	induced,in
R5008	T6578	T6585	arg1Of	induced,","
R5009	T6578	T6586	arg1Of	induced,as
R5010	T6582	T6580	arg2Of	absence,in
R5011	T6582	T6581	arg1Of	absence,the
R5012	T6582	T6583	arg1Of	absence,of
R5013	T6584	T6583	arg2Of	IL-4,of
R5014	T6542	T6543	arg1Of	presence,of
R5015	T6544	T6545	arg1Of	TGF-β,and/or
R5016	T6587	T6588	arg1Of	it,was
R5017	T6587	T6590	arg2Of	it,observed
R5018	T6545	T6543	arg2Of	and/or,of
R5019	T6590	T6586	arg2Of	observed,as
R5020	T6590	T6588	arg2Of	observed,was
R5021	T6590	T6589	arg1Of	observed,previously
R5022	T6590	T6591	arg1Of	observed,[
R5023	T6592	T6591	arg2Of	3,[
R5024	T6593	T6591	arg3Of	],[
R5025	T6546	T6545	arg2Of	IL-4,and/or
R5026	T6644	T6641	arg2Of	signaling,of
R5027	T6598	T6596	arg2Of	concentration,at
R5028	T6598	T6597	arg1Of	concentration,low
R5029	T6600	T6601	arg1Of	IL-4,was
R5030	T6600	T6602	arg1Of	IL-4,able
R5031	T6600	T6605	arg1Of	IL-4,induce
R5032	T6601	T6594	arg1Of	was,However
R5033	T6601	T6595	arg1Of	was,","
R5034	T6601	T6596	arg1Of	was,at
R5035	T6601	T6599	arg1Of	was,","
R5036	T6602	T6601	arg2Of	able,was
R5037	T6644	T6642	arg1Of	signaling,the
R5038	T6644	T6643	arg1Of	signaling,receptor
R5039	T6605	T6602	arg2Of	induce,able
R5040	T6605	T6603	arg1Of	induce,to
R5041	T6605	T6604	arg1Of	induce,marginally
R5042	T6607	T6605	arg2Of	expression,induce
R5043	T6607	T6606	arg1Of	expression,FOXP3
R5044	T6609	T6608	arg2Of	note,Of
R5045	T6648	T6647	arg1Of	phosphorylation,the
R5046	T6611	T6612	arg1Of	GATA3,was
R5047	T6611	T6614	arg2Of	GATA3,induced
R5048	T6614	T6608	arg1Of	induced,Of
R5049	T6614	T6610	arg1Of	induced,","
R5050	T6614	T6612	arg2Of	induced,was
R5051	T6614	T6613	arg1Of	induced,also
R5052	T6614	T6615	arg1Of	induced,in
R5053	T6617	T6615	arg2Of	presence,in
R5054	T6617	T6616	arg1Of	presence,the
R5055	T6617	T6618	arg1Of	presence,of
R5056	T6617	T6620	arg1Of	presence,at
R5057	T6619	T6618	arg2Of	TGF-β,of
R5058	T6648	T6649	arg1Of	phosphorylation,of
R5059	T6648	T6653	arg1Of	phosphorylation,was
R5060	T6648	T6655	arg2Of	phosphorylation,affected
R5061	T6623	T6620	arg2Of	concentration,at
R5062	T6623	T6621	arg1Of	concentration,high
R5063	T6623	T6622	arg1Of	concentration,IL-4
R5064	T6650	T6651	arg1Of	SMAD2,or
R5065	T6623	T6624	arg1Of	concentration,(
R5066	T6651	T6649	arg2Of	or,of
R5067	T6626	T6625	arg1Of	5A,Figure
R5068	T6626	T6627	arg1Of	5A,and
R5069	T6627	T6624	arg2Of	and,(
R5070	T6652	T6651	arg2Of	STAT6,or
R5071	T6628	T6627	arg2Of	5B,and
R5072	T6629	T6624	arg3Of	),(
R5073	T6655	T6646	arg2Of	affected,because
R5074	T6632	T6630	arg1Of	prevention,The
R5075	T6632	T6631	arg1Of	prevention,IL-4–mediated
R5076	T6632	T6633	arg1Of	prevention,of
R5077	T6632	T6636	arg1Of	prevention,was
R5078	T6632	T6638	arg2Of	prevention,caused
R5079	T6635	T6633	arg2Of	expression,of
R5080	T6635	T6634	arg1Of	expression,FOXP3
R5081	T6655	T6653	arg2Of	affected,was
R5082	T6655	T6654	arg1Of	affected,not
R5083	T6638	T6636	arg2Of	caused,was
R5084	T6638	T6637	arg1Of	caused,not
R5085	T6638	T6645	arg1Of	caused,","
R5086	T6638	T6646	arg1Of	caused,because
R5087	T6658	T6655	arg1Of	addition,affected
R5088	T6640	T6638	arg1Of	interferences,caused
R5089	T6640	T6639	arg2Of	interferences,by
R5090	T6640	T6641	arg1Of	interferences,of
R5091	T6658	T6656	arg2Of	addition,by
R5092	T6658	T6657	arg1Of	addition,the
R5093	T6658	T6659	arg1Of	addition,of
R5094	T6658	T6663	arg1Of	addition,","
R5095	T6658	T6664	arg1Of	addition,which
R5096	T6658	T6665	arg1Of	addition,demonstrates
R5097	T6660	T6661	arg1Of	IL-4,and/or
R5098	T6661	T6659	arg2Of	and/or,of
R5099	T6741	T6739	arg2Of	CD25,express
R5100	T6741	T6740	arg1Of	CD25,surface
R5101	T6742	T6743	arg1Of	We,used
R5102	T6662	T6661	arg2Of	TGF-β,and/or
R5103	T6744	T6745	arg1Of	complexes,of
R5104	T6744	T6752	arg1Of	complexes,plus
R5105	T6667	T6670	arg1Of	IL-4,as
R5106	T6748	T6745	arg2Of	IL-4,of
R5107	T6748	T6746	arg1Of	IL-4,recombinant
R5108	T6748	T6747	arg1Of	IL-4,mouse
R5109	T6748	T6749	arg1Of	IL-4,(
R5110	T6750	T6749	arg2Of	rmIL-4,(
R5111	T6751	T6749	arg3Of	),(
R5112	T6752	T6743	arg2Of	plus,used
R5113	T6670	T6668	arg1Of	as,as
R5114	T6755	T6752	arg2Of	antibodies,plus
R5115	T6755	T6753	arg1Of	antibodies,anti-IL-4
R5116	T6755	T6754	arg1Of	antibodies,monoclonal
R5117	T6755	T6756	arg1Of	antibodies,(
R5118	T6755	T6759	arg1Of	antibodies,","
R5119	T6755	T6760	arg1Of	antibodies,which
R5120	T6755	T6761	arg1Of	antibodies,have
R5121	T6755	T6762	arg1Of	antibodies,been
R5122	T6755	T6763	arg2Of	antibodies,shown
R5123	T6755	T6766	arg1Of	antibodies,increase
R5124	T6757	T6756	arg2Of	mAbs,(
R5125	T6758	T6756	arg3Of	),(
R5126	T6670	T6669	arg1Of	as,well
R5127	T6670	T6673	arg1Of	as,were
R5128	T6763	T6761	arg2Of	shown,have
R5129	T6763	T6762	arg2Of	shown,been
R5130	T6670	T6674	arg1Of	as,functional
R5131	T6672	T6670	arg2Of	signaling,as
R5132	T6763	T6774	arg1Of	shown,[
R5133	T6672	T6671	arg1Of	signaling,TGF-β
R5134	T6766	T6763	arg3Of	increase,shown
R5135	T6766	T6764	arg1Of	increase,to
R5136	T6766	T6765	arg1Of	increase,dramatically
R5137	T6673	T6665	arg2Of	were,demonstrates
R5138	T6768	T6766	arg2Of	potency,increase
R5139	T6768	T6767	arg1Of	potency,the
R5140	T6768	T6769	arg1Of	potency,of
R5141	T6768	T6773	arg1Of	potency,vivo
R5142	T6771	T6769	arg2Of	cytokine,of
R5143	T6771	T6770	arg1Of	cytokine,the
R5144	T6773	T6772	arg1Of	vivo,in
R5145	T6775	T6774	arg2Of	19,[
R5146	T6776	T6774	arg3Of	],[
R5147	T6673	T6666	arg1Of	were,that
R5148	T6673	T6675	arg1Of	were,under
R5149	T6674	T6673	arg2Of	functional,were
R5150	T6779	T6777	arg2Of	mice,In
R5151	T6779	T6778	arg1Of	mice,these
R5152	T6782	T6781	arg1Of	percentage,the
R5153	T6677	T6675	arg2Of	conditions,under
R5154	T6782	T6783	arg1Of	percentage,of
R5155	T6782	T6790	arg1Of	percentage,decreased
R5156	T6784	T6785	arg1Of	CD4+CD25+,and
R5157	T6786	T6785	arg2Of	FOXP3+,and
R5158	T6788	T6783	arg2Of	cells,of
R5159	T6788	T6784	arg1Of	cells,CD4+CD25+
R5160	T6788	T6786	arg1Of	cells,FOXP3+
R5161	T6788	T6787	arg1Of	cells,T
R5162	T6790	T6777	arg1Of	decreased,In
R5163	T6790	T6780	arg1Of	decreased,","
R5164	T6790	T6789	arg1Of	decreased,dramatically
R5165	T6790	T6791	arg1Of	decreased,when
R5166	T6677	T6676	arg1Of	conditions,these
R5167	T6677	T6678	arg1Of	conditions,(
R5168	T6680	T6678	arg2Of	5C,(
R5169	T6795	T6792	arg1Of	complexes,the
R5170	T6795	T6793	arg1Of	complexes,antibody-cytokine
R5171	T6795	T6794	arg1Of	complexes,immune
R5172	T6795	T6796	arg1Of	complexes,were
R5173	T6795	T6797	arg2Of	complexes,injected
R5174	T6797	T6791	arg2Of	injected,when
R5175	T6797	T6796	arg2Of	injected,were
R5176	T6797	T6798	arg1Of	injected,(
R5177	T6800	T6798	arg2Of	S2,(
R5178	T6800	T6799	arg1Of	S2,Figure
R5179	T6801	T6798	arg3Of	),(
R5180	T6803	T6802	arg1Of	administration,Upon
R5181	T6680	T6679	arg1Of	5C,Figure
R5182	T6681	T6678	arg3Of	),(
R5183	T6803	T6804	arg1Of	administration,of
R5184	T6803	T6821	arg1Of	administration,as
R5185	T6682	T6689	arg1Of	Increasing,","
R5186	T6682	T6690	arg1Of	Increasing,whereas
R5187	T6683	T6682	arg2Of	amounts,Increasing
R5188	T6809	T6805	arg1Of	complexes,rmIL-4
R5189	T6809	T6806	arg1Of	complexes,plus
R5190	T6809	T6807	arg1Of	complexes,anti-IL-4
R5191	T6809	T6808	arg1Of	complexes,mAb
R5192	T6809	T6810	arg1Of	complexes,","
R5193	T6810	T6804	arg2Of	",",of
R5194	T6813	T6810	arg2Of	number,","
R5195	T6813	T6811	arg1Of	number,the
R5196	T6813	T6812	arg1Of	number,total
R5197	T6813	T6814	arg1Of	number,of
R5198	T6683	T6684	arg1Of	amounts,of
R5199	T6688	T6684	arg2Of	GATA3,of
R5200	T6817	T6814	arg2Of	cell,of
R5201	T6817	T6815	arg1Of	cell,CD4+CD25+
R5202	T6817	T6816	arg1Of	cell,T
R5203	T6821	T6818	arg1Of	as,","
R5204	T6821	T6819	arg1Of	as,as
R5205	T6821	T6820	arg1Of	as,well
R5206	T6825	T6821	arg2Of	cells,as
R5207	T6825	T6822	arg1Of	cells,the
R5208	T6825	T6823	arg1Of	cells,Foxp3+
R5209	T6825	T6824	arg1Of	cells,T
R5210	T6825	T6826	arg2Of	cells,diminished
R5211	T6826	T6835	arg1Of	diminished,","
R5212	T6826	T6836	modOf	diminished,confirming
R5213	T6828	T6826	arg1Of	half,diminished
R5214	T6828	T6827	arg2Of	half,by
R5215	T6828	T6829	arg1Of	half,(
R5216	T6688	T6685	arg1Of	GATA3,IL-4
R5217	T6688	T6686	arg1Of	GATA3,increase
R5218	T6831	T6830	arg1Of	S2G,Figure
R5219	T6831	T6832	arg1Of	S2G,and
R5220	T6688	T6687	arg1Of	GATA3,intracellular
R5221	T6832	T6829	arg2Of	and,(
R5222	T6691	T6692	arg1Of	FOXP3,decreased
R5223	T6833	T6832	arg2Of	S2H,and
R5224	T6834	T6829	arg3Of	),(
R5225	T6692	T6690	arg2Of	decreased,whereas
R5226	T6692	T6693	arg1Of	decreased,","
R5227	T6692	T6694	arg1Of	decreased,which
R5228	T6692	T6695	arg1Of	decreased,is
R5229	T6840	T6838	arg1Of	percentage,the
R5230	T6840	T6839	arg1Of	percentage,lower
R5231	T6840	T6841	arg1Of	percentage,was
R5232	T6840	T6843	arg1Of	percentage,due
R5233	T6841	T6836	arg2Of	was,confirming
R5234	T6841	T6837	arg1Of	was,that
R5235	T6841	T6842	arg1Of	was,not
R5236	T6843	T6841	arg2Of	due,was
R5237	T6692	T6696	arg1Of	decreased,consistent
R5238	T6696	T6695	arg2Of	consistent,is
R5239	T6843	T6844	arg1Of	due,to
R5240	T6696	T6697	arg1Of	consistent,with
R5241	T6846	T6845	arg1Of	increase,an
R5242	T6846	T6847	arg1Of	increase,in
R5243	T6846	T6852	arg1Of	increase,but
R5244	T6700	T6697	arg2Of	analysis,with
R5245	T6850	T6847	arg2Of	cells,in
R5246	T6850	T6848	arg1Of	cells,the
R5247	T6850	T6849	arg1Of	cells,CD4+CD25–
R5248	T6852	T6844	arg2Of	but,to
R5249	T6852	T6851	arg1Of	but,","
R5250	T6855	T6852	arg2Of	decrease,but
R5251	T6855	T6853	arg1Of	decrease,a
R5252	T6855	T6854	arg1Of	decrease,real
R5253	T6855	T6856	arg1Of	decrease,of
R5254	T6700	T6698	arg1Of	analysis,the
R5255	T6700	T6699	arg1Of	analysis,mRNA
R5256	T6700	T6701	arg1Of	analysis,(
R5257	T6859	T6856	arg2Of	cells,of
R5258	T6859	T6857	arg1Of	cells,CD4+CD25+
R5259	T6859	T6858	arg1Of	cells,T
R5260	T6703	T6701	arg2Of	5D,(
R5261	T6861	T6860	arg2Of	conclusion,In
R5262	T6863	T6865	arg1Of	IL-4,regulates
R5263	T6865	T6860	arg1Of	regulates,In
R5264	T6865	T6862	arg1Of	regulates,","
R5265	T6865	T6864	arg1Of	regulates,negatively
R5266	T6865	T6876	arg1Of	regulates,vitro
R5267	T6865	T6880	arg1Of	regulates,vivo
R5268	T6867	T6868	arg1Of	natural,or
R5269	T6703	T6702	arg1Of	5D,Figure
R5270	T6869	T6868	arg2Of	inducible,or
R5271	T6704	T6701	arg3Of	),(
R5272	T6707	T6708	arg1Of	injection,of
R5273	T6872	T6865	arg2Of	turnover,regulates
R5274	T6872	T6866	arg1Of	turnover,the
R5275	T6872	T6867	arg1Of	turnover,natural
R5276	T6872	T6869	arg1Of	turnover,inducible
R5277	T6872	T6870	arg1Of	turnover,Treg
R5278	T6872	T6871	arg1Of	turnover,cell
R5279	T6874	T6873	arg1Of	only,not
R5280	T6875	T6874	arg1Of	in,only
R5281	T6876	T6875	arg1Of	vitro,in
R5282	T6876	T6877	arg1Of	vitro,but
R5283	T6877	T6878	arg1Of	but,also
R5284	T6880	T6877	arg2Of	vivo,but
R5285	T6880	T6879	arg1Of	vivo,in
R5286	T6707	T6710	arg1Of	injection,into
R5287	T6707	T6714	arg1Of	injection,decreased
R5288	T6882	T6881	arg1Of	study,To
R5289	T6709	T6708	arg2Of	IL-4,of
R5290	T6884	T6882	arg2Of	effects,study
R5291	T6884	T6883	arg1Of	effects,the
R5292	T6884	T6885	arg1Of	effects,of
R5293	T6884	T6887	arg1Of	effects,on
R5294	T6886	T6885	arg2Of	IL-4,of
R5295	T6890	T6891	arg1Of	natural,or
R5296	T6713	T6710	arg2Of	mice,into
R5297	T6892	T6891	arg2Of	inducible,or
R5298	T6894	T6887	arg2Of	cells,on
R5299	T6894	T6888	arg1Of	cells,already-existing
R5300	T6894	T6889	arg1Of	cells,human
R5301	T6894	T6890	arg1Of	cells,natural
R5302	T6894	T6892	arg1Of	cells,inducible
R5303	T6894	T6893	arg1Of	cells,Treg
R5304	T6896	T6882	arg1Of	we,study
R5305	T6896	T6897	arg1Of	we,exposed
R5306	T6897	T6881	modOf	exposed,To
R5307	T6897	T6895	arg1Of	exposed,","
R5308	T6897	T6906	arg1Of	exposed,to
R5309	T6713	T6711	arg1Of	mice,wild-type
R5310	T6713	T6712	arg1Of	mice,B6
R5311	T6901	T6897	arg2Of	cells,exposed
R5312	T6901	T6898	arg2Of	cells,sorted
R5313	T6901	T6899	arg1Of	cells,CD25+
R5314	T6901	T6900	arg1Of	cells,T
R5315	T6901	T6902	arg1Of	cells,(
R5316	T6904	T6902	arg2Of	cells,(
R5317	T6904	T6903	arg1Of	cells,nTreg
R5318	T6905	T6902	arg3Of	),(
R5319	T6714	T6705	arg1Of	decreased,Furthermore
R5320	T6907	T6908	arg1Of	IL-4,and
R5321	T6908	T6912	arg1Of	and,and
R5322	T6714	T6706	arg1Of	decreased,","
R5323	T6714	T6722	arg1Of	decreased,vivo
R5324	T6716	T6717	arg1Of	inducible,or
R5325	T6911	T6908	arg2Of	expression,and
R5326	T6911	T6909	arg2Of	expression,analyzed
R5327	T6911	T6910	arg1Of	expression,FOXP3
R5328	T6912	T6906	arg2Of	and,to
R5329	T6914	T6912	arg2Of	capacity,and
R5330	T6914	T6913	arg1Of	capacity,suppressive
R5331	T6718	T6717	arg2Of	natural,or
R5332	T6918	T6915	arg2Of	cells,In
R5333	T6720	T6714	arg2Of	number,decreased
R5334	T6918	T6916	arg1Of	cells,already-existing
R5335	T6918	T6917	arg1Of	cells,Treg
R5336	T6920	T6921	arg1Of	IL-4,failed
R5337	T6920	T6923	arg1Of	IL-4,inhibit
R5338	T6720	T6715	arg1Of	number,the
R5339	T6921	T6915	arg1Of	failed,In
R5340	T6921	T6919	arg1Of	failed,","
R5341	T6720	T6716	arg1Of	number,inducible
R5342	T6921	T6931	arg1Of	failed,and
R5343	T6720	T6718	arg1Of	number,natural
R5344	T6720	T6719	arg1Of	number,Treg
R5345	T6722	T6721	arg1Of	vivo,in
R5346	T6923	T6921	arg2Of	inhibit,failed
R5347	T6923	T6922	arg1Of	inhibit,to
R5348	T6925	T6923	arg2Of	expression,inhibit
R5349	T6925	T6924	arg1Of	expression,FOXP3
R5350	T6925	T6926	arg1Of	expression,(
R5351	T6724	T6723	arg1Of	distinction,A
R5352	T6928	T6926	arg2Of	S3A,(
R5353	T6928	T6927	arg1Of	S3A,Figure
R5354	T6929	T6926	arg3Of	),(
R5355	T6931	T6930	arg1Of	and,","
R5356	T6724	T6725	arg1Of	distinction,of
R5357	T6724	T6729	arg1Of	distinction,is
R5358	T6724	T6731	arg1Of	distinction,possible
R5359	T6934	T6932	arg1Of	capacity,the
R5360	T6934	T6933	arg1Of	capacity,suppressive
R5361	T6934	T6935	arg1Of	capacity,was
R5362	T6934	T6937	arg2Of	capacity,altered
R5363	T6728	T6725	arg2Of	subsets,of
R5364	T6728	T6726	arg1Of	subsets,the
R5365	T6937	T6931	arg2Of	altered,and
R5366	T6937	T6935	arg2Of	altered,was
R5367	T6937	T6936	arg1Of	altered,not
R5368	T6937	T6938	arg1Of	altered,(
R5369	T6728	T6727	arg1Of	subsets,Treg
R5370	T6940	T6938	arg2Of	S3C,(
R5371	T6940	T6939	arg1Of	S3C,Figure
R5372	T6941	T6938	arg3Of	),(
R5373	T6729	T6730	arg1Of	is,not
R5374	T6943	T6942	arg1Of	pre-existing,Similarly
R5375	T6729	T6732	arg1Of	is,","
R5376	T6729	T6733	arg1Of	is,because
R5377	T6945	T6943	arg1Of	cells,pre-existing
R5378	T6945	T6944	arg1Of	cells,iTreg
R5379	T6945	T6946	arg1Of	cells,did
R5380	T6945	T6948	arg1Of	cells,decrease
R5381	T6731	T6729	arg2Of	possible,is
R5382	T6948	T6946	arg2Of	decrease,did
R5383	T6948	T6947	arg1Of	decrease,not
R5384	T6948	T6951	arg1Of	decrease,upon
R5385	T6950	T6948	arg2Of	expression,decrease
R5386	T6950	T6949	arg1Of	expression,FOXP3
R5387	T6735	T6734	arg1Of	activated,recently
R5388	T6953	T6951	arg2Of	exposure,upon
R5389	T6953	T6952	arg1Of	exposure,IL-4
R5390	T6953	T6954	arg1Of	exposure,(
R5391	T6956	T6954	arg2Of	S3B,(
R5392	T6956	T6955	arg1Of	S3B,Figure
R5393	T6957	T6954	arg3Of	),(
R5394	T6737	T6735	arg1Of	cells,activated
R5395	T6737	T6736	arg1Of	cells,iTreg
R5396	T6737	T6739	arg1Of	cells,express
R5397	T6739	T6733	arg2Of	express,because
R5398	T6739	T6738	arg1Of	express,also
R18709	T25158	T25159	arg1Of	Effect,of
R18710	T25158	T25161	arg1Of	Effect,on
R18711	T25160	T25159	arg2Of	IL-4,of
R18712	T25163	T25161	arg2Of	Induction,on
R18713	T25163	T25162	arg1Of	Induction,FOXP3
R18714	T25165	T25164	arg2Of	A,(
R18715	T25166	T25164	arg3Of	),(
R18716	T25169	T25164	arg1Of	analysis,(
R18717	T25169	T25167	arg1Of	analysis,A
R18718	T25169	T25168	arg1Of	analysis,statistical
R18719	T25169	T25170	arg1Of	analysis,was
R18720	T25169	T25171	arg2Of	analysis,performed
R18721	T25171	T25170	arg2Of	performed,was
R18722	T25171	T25172	arg1Of	performed,with
R18723	T25171	T25185	arg1Of	performed,with
R18724	T25171	T25187	arg1Of	performed,without
R18725	T25171	T25194	arg1Of	performed,;
R18726	T25172	T25184	arg1Of	with,and
R18727	T25174	T25172	arg2Of	donors,with
R18728	T25174	T25173	arg1Of	donors,six
R18729	T25174	T25175	arg1Of	donors,on
R18730	T25179	T25175	arg2Of	TGF-β,on
R18731	T25179	T25176	arg1Of	TGF-β,day
R18732	T25179	T25177	arg1Of	TGF-β,5
R18733	T25179	T25178	arg1Of	TGF-β,(
R18734	T25179	T25180	arg1Of	TGF-β,(
R18735	T25182	T25180	arg2Of	ng/ml,(
R18736	T25182	T25181	arg1Of	ng/ml,10
R18737	T25183	T25180	arg3Of	),(
R18738	T25185	T25186	arg1Of	with,or
R18739	T25186	T25184	arg2Of	or,and
R18740	T25187	T25186	arg2Of	without,or
R18741	T25188	T25185	arg2Of	IL-4,with
R18742	T25188	T25187	arg2Of	IL-4,without
R18743	T25188	T25189	arg1Of	IL-4,(
R18744	T25188	T25193	arg1Of	IL-4,)
R18745	T25191	T25189	arg2Of	ng/ml,(
R18746	T25191	T25190	arg1Of	ng/ml,100
R18747	T25192	T25189	arg3Of	),(
R18748	T25195	T25196	arg1Of	Shown,is
R18749	T25196	T25200	arg1Of	is,and
R18750	T25198	T25196	arg2Of	mean,is
R18751	T25198	T25197	arg1Of	mean,the
R18752	T25200	T25194	arg2Of	and,;
R18753	T25200	T25199	arg1Of	and,","
R18754	T25202	T25201	arg1Of	bars,error
R18755	T25202	T25203	arg1Of	bars,indicated
R18756	T25203	T25200	arg2Of	indicated,and
R18757	T25205	T25203	arg2Of	SD,indicated
R18758	T25205	T25204	arg1Of	SD,the
R18759	T25205	T25206	arg1Of	SD,of
R18760	T25208	T25206	arg2Of	donors,of
R18761	T25208	T25207	arg1Of	donors,six
R18762	T25210	T25209	arg1Of	analysis,Statistical
R18763	T25210	T25211	arg1Of	analysis,was
R18764	T25210	T25212	arg2Of	analysis,performed
R18765	T25212	T25211	arg2Of	performed,was
R18766	T25213	T25212	arg3Of	using,performed
R18767	T25216	T25213	arg2Of	test,using
R18768	T25216	T25214	arg1Of	test,the
R18769	T25216	T25215	arg1Of	test,Dunnett
R18770	T25218	T25217	arg1Of	significance,Statistical
R18771	T25218	T25219	arg1Of	significance,is
R18772	T25218	T25220	arg2Of	significance,indicated
R18773	T25220	T25219	arg2Of	indicated,is
R18774	T25222	T25220	arg1Of	asterisks,indicated
R18775	T25222	T25221	arg2Of	asterisks,by
R18776	T25222	T25223	arg1Of	asterisks,(
R18777	T25225	T25223	arg2Of	≤,(
R18778	T25225	T25224	arg1Of	≤,*p
R18779	T25225	T25226	arg1Of	≤,0.05
R18780	T25225	T25227	arg1Of	≤,","
R18781	T25228	T25227	arg2Of	**p,","
R18782	T25228	T25230	arg1Of	**p,0.01
R18783	T25228	T25231	arg1Of	**p,","
R18784	T25230	T25229	arg1Of	0.01,≤
R18785	T25232	T25231	arg2Of	Dunnett,","
R18786	T25233	T25223	arg3Of	),(
R18787	T25235	T25234	arg2Of	B,(
R18788	T25236	T25234	arg3Of	),(
R18789	T25238	T25234	arg1Of	cells,(
R18790	T25238	T25237	arg1Of	cells,CD4+CD45RA+
R18791	T25238	T25239	arg1Of	cells,were
R18792	T25238	T25240	arg2Of	cells,activated
R18793	T25240	T25239	arg2Of	activated,were
R18794	T25240	T25241	arg1Of	activated,in
R18795	T25240	T25260	arg1Of	activated,","
R18796	T25240	T25261	arg1Of	activated,as
R18797	T25241	T25242	arg1Of	in,the
R18798	T25241	T25244	arg1Of	in,of
R18799	T25243	T25241	arg2Of	presence,in
R18800	T25247	T25241	arg3Of	concentration,in
R18801	T25247	T25245	arg1Of	concentration,a
R18802	T25247	T25246	arg1Of	concentration,constant
R18803	T25247	T25248	arg1Of	concentration,of
R18804	T25247	T25254	arg1Of	concentration,with
R18805	T25249	T25248	arg2Of	TGF-β,of
R18806	T25249	T25250	arg1Of	TGF-β,(
R18807	T25252	T25250	arg2Of	ng/ml,(
R18808	T25252	T25251	arg1Of	ng/ml,5
R18809	T25253	T25250	arg3Of	),(
R18810	T25257	T25254	arg2Of	concentration,with
R18811	T25257	T25255	arg1Of	concentration,an
R18812	T25257	T25256	arg1Of	concentration,increasing
R18813	T25257	T25258	arg1Of	concentration,of
R18814	T25259	T25258	arg2Of	IL-4,of
R18815	T25262	T25261	arg2Of	indicated,as
R18816	T25263	T25264	arg1Of	Cells,were
R18817	T25263	T25265	arg2Of	Cells,harvested
R18818	T25265	T25264	arg2Of	harvested,were
R18819	T25265	T25266	arg1Of	harvested,for
R18820	T25265	T25269	arg1Of	harvested,after
R18821	T25268	T25266	arg2Of	quantification,for
R18822	T25268	T25267	arg1Of	quantification,mRNA
R18823	T25271	T25269	arg2Of	d,after
R18824	T25271	T25270	arg1Of	d,5
R18825	T25273	T25272	arg2Of	C,(
R18826	T25274	T25272	arg3Of	),(
R18827	T25276	T25272	arg1Of	cells,(
R18828	T25276	T25275	arg1Of	cells,CD4+CD45RA+
R18829	T25276	T25277	arg1Of	cells,were
R18830	T25276	T25278	arg2Of	cells,stimulated
R18831	T25278	T25277	arg2Of	stimulated,were
R18832	T25278	T25280	arg1Of	stimulated,vitro
R18833	T25278	T25281	arg1Of	stimulated,with
R18834	T25278	T25296	arg1Of	stimulated,as
R18835	T25280	T25279	arg1Of	vitro,in
R18836	T25283	T25282	arg1Of	anti-CD3/CD28,plate-bound
R18837	T25283	T25284	arg1Of	anti-CD3/CD28,","
R18838	T25284	T25290	arg1Of	",",and
R18839	T25285	T25284	arg2Of	TGF-β,","
R18840	T25285	T25286	arg1Of	TGF-β,(
R18841	T25287	T25286	arg2Of	10ng/ml,(
R18842	T25288	T25286	arg3Of	),(
R18843	T25290	T25281	arg2Of	and,with
R18844	T25290	T25289	arg1Of	and,","
R18845	T25291	T25290	arg2Of	IL-4,and
R18846	T25291	T25292	arg1Of	IL-4,(
R18847	T25294	T25292	arg2Of	ng/ml,(
R18848	T25294	T25293	arg1Of	ng/ml,100
R18849	T25295	T25292	arg3Of	),(
R18850	T25297	T25296	arg2Of	indicated,as
R18851	T25300	T25298	arg2Of	h,After
R18852	T25300	T25299	arg1Of	h,1
R18853	T25303	T25302	arg1Of	lysates,cell
R18854	T25303	T25304	arg1Of	lysates,were
R18855	T25303	T25305	arg2Of	lysates,prepared
R18856	T25303	T25307	arg2Of	lysates,analyzed
R18857	T25305	T25306	arg1Of	prepared,and
R18858	T25306	T25298	arg1Of	and,After
R18859	T25306	T25301	arg1Of	and,","
R18860	T25306	T25304	arg2Of	and,were
R18861	T25307	T25306	arg2Of	analyzed,and
R18862	T25310	T25305	arg1Of	blot,prepared
R18863	T25310	T25307	arg1Of	blot,analyzed
R18864	T25310	T25308	arg2Of	blot,by
R18865	T25310	T25309	arg1Of	blot,Western
R18866	T25310	T25311	arg1Of	blot,for
R18867	T25313	T25314	arg1Of	SMAD2,and
R18868	T25314	T25311	arg2Of	and,for
R18869	T25314	T25312	arg2Of	and,phosphorylated
R18870	T25315	T25314	arg2Of	STAT6,and
R18871	T25317	T25318	arg1Of	STAT6,and
R18872	T25318	T25316	arg1Of	and,Total
R18873	T25318	T25320	arg1Of	and,served
R18874	T25319	T25318	arg2Of	GAPDH,and
R18875	T25320	T25321	arg1Of	served,as
R18876	T25323	T25321	arg2Of	control,as
R18877	T25323	T25322	arg1Of	control,internal
R18878	T25325	T25324	arg2Of	D,(
R18879	T25326	T25324	arg3Of	),(
R18880	T25328	T25329	arg1Of	GATA3,and
R18881	T25330	T25329	arg2Of	FOXP3,and
R18882	T25331	T25324	arg1Of	staining,(
R18883	T25331	T25327	arg1Of	staining,Intracellular
R18884	T25331	T25328	arg1Of	staining,GATA3
R18885	T25331	T25330	arg1Of	staining,FOXP3
R18886	T25331	T25332	arg1Of	staining,are
R18887	T25331	T25333	arg2Of	staining,shown
R18888	T25333	T25332	arg2Of	shown,are
R18889	T25333	T25334	arg1Of	shown,after
R18890	T25335	T25334	arg2Of	exposure,after
R18891	T25335	T25336	arg1Of	exposure,of
R18892	T25339	T25336	arg2Of	cells,of
R18893	T25339	T25337	arg1Of	cells,CD4+CD45RA+
R18894	T25339	T25338	arg1Of	cells,T
R18895	T25341	T25340	arg1Of	IL-4,to
R18896	T25341	T25342	arg1Of	IL-4,as
R18897	T25341	T25348	arg1Of	IL-4,are
R18898	T25341	T25349	arg1Of	IL-4,representative
R18899	T25343	T25342	arg2Of	described,as
R18900	T25343	T25344	arg1Of	described,for
R18901	T25347	T25344	arg2Of	Data,for
R18902	T25347	T25345	arg1Of	Data,panel
R18903	T25347	T25346	arg1Of	Data,B.
R18904	T25348	T25332	modOf	are,are
R18905	T25349	T25348	arg2Of	representative,are
R18906	T25349	T25350	arg1Of	representative,of
R18907	T25353	T25350	arg2Of	experiments,of
R18908	T25353	T25351	arg1Of	experiments,three
R18909	T25353	T25352	arg1Of	experiments,independent

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T6958	2546-2570	Anaphor	denotes	the suppressive capacity
T6959	2503-2510	Antecedent	denotes	inhibit
R5400	T6958	T6959	boundBy	the suppressive capacity,inhibit

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T7041	0-4	NN	denotes	IL-4
T7042	5-13	NNS	denotes	Inhibits
T7043	14-28	JJ	denotes	TGF-β-Mediated
T7044	29-34	NNP	denotes	iTreg
T7045	35-45	NNP	denotes	Commitment
T7046	46-50	NN	denotes	IL-4
T7047	51-58	VBZ	denotes	induces
T7048	59-74	NN	denotes	differentiation
T7049	75-77	IN	denotes	of
T7050	78-83	JJ	denotes	naive
T7051	84-85	NNP	denotes	T
T7052	86-91	NNS	denotes	cells
T7053	91-92	,	denotes	,
T7054	93-97	IN	denotes	upon
T7055	98-105	NN	denotes	antigen
T7056	106-115	NN	denotes	encounter
T7057	115-116	,	denotes	,
T7058	117-121	IN	denotes	into
T7059	122-125	DT	denotes	the
T7060	126-129	NNP	denotes	Th2
T7061	130-134	NN	denotes	cell
T7062	135-142	NN	denotes	lineage
T7063	142-143	.	denotes	.
T7064	144-146	PRP	denotes	We
T7065	147-156	RB	denotes	therefore
T7066	157-162	VBD	denotes	asked
T7067	163-170	IN	denotes	whether
T7068	171-175	NN	denotes	IL-4
T7069	176-178	VBZ	denotes	is
T7070	179-183	JJ	denotes	able
T7071	184-186	TO	denotes	to
T7072	187-194	VB	denotes	inhibit
T7073	195-200	JJ	denotes	TGF-β
T7074	201-210	NN	denotes	induction
T7075	211-213	IN	denotes	of
T7076	214-219	CD	denotes	FOXP3
T7077	220-226	IN	denotes	during
T7078	227-230	DT	denotes	the
T7079	231-238	NN	denotes	priming
T7080	239-241	IN	denotes	of
T7081	242-247	JJ	denotes	naive
T7082	248-249	NNP	denotes	T
T7083	250-255	NNS	denotes	cells
T7084	255-256	.	denotes	.
T7085	257-262	NNP	denotes	Human
T7086	263-266	NNP	denotes	CD4
T7087	266-267	NNP	denotes	+
T7088	267-273	NNP	denotes	CD45RA
T7089	273-274	VBD	denotes	+
T7090	275-276	NNP	denotes	T
T7091	277-282	NNS	denotes	cells
T7092	283-287	VBD	denotes	were
T7093	288-297	VBN	denotes	activated
T7094	298-302	IN	denotes	with
T7095	303-314	JJ	denotes	plate-bound
T7096	315-323	JJ	denotes	anti-CD3
T7097	323-324	NN	denotes	/
T7098	324-328	CD	denotes	CD28
T7099	329-331	IN	denotes	in
T7100	332-335	DT	denotes	the
T7101	336-344	NN	denotes	presence
T7102	345-347	IN	denotes	of
T7103	348-353	NNP	denotes	TGF-β
T7104	354-360	CC	denotes	and/or
T7105	361-365	NN	denotes	IL-4
T7106	366-369	CC	denotes	and
T7107	370-379	VBN	denotes	harvested
T7108	380-385	IN	denotes	after
T7109	386-387	CD	denotes	5
T7110	388-390	NN	denotes	d.
T7111	391-395	NN	denotes	IL-4
T7112	396-407	RB	denotes	efficiently
T7113	408-417	VBD	denotes	repressed
T7114	418-421	DT	denotes	the
T7115	422-427	NNP	denotes	TGF-β
T7116	428-436	VBD	denotes	mediated
T7117	437-446	NN	denotes	induction
T7118	447-449	IN	denotes	of
T7119	450-455	CD	denotes	FOXP3
T7120	456-466	NN	denotes	expression
T7121	467-468	-LRB-	denotes	(
T7122	468-474	NN	denotes	Figure
T7123	475-477	NN	denotes	5A
T7124	477-478	-RRB-	denotes	)
T7125	479-481	IN	denotes	in
T7126	482-483	DT	denotes	a
T7127	484-507	JJ	denotes	concentration-dependent
T7128	508-514	NN	denotes	manner
T7129	515-516	-LRB-	denotes	(
T7130	516-522	NN	denotes	Figure
T7131	523-525	NN	denotes	5B
T7132	525-526	-RRB-	denotes	)
T7133	526-527	.	denotes	.
T7134	528-531	NNP	denotes	Low
T7135	532-538	NNS	denotes	levels
T7136	539-541	IN	denotes	of
T7137	542-547	CD	denotes	GATA3
T7138	548-552	VBD	denotes	were
T7139	553-560	VBN	denotes	induced
T7140	561-565	RB	denotes	also
T7141	566-568	IN	denotes	in
T7142	569-572	DT	denotes	the
T7143	573-580	NN	denotes	absence
T7144	581-583	IN	denotes	of
T7145	584-588	NN	denotes	IL-4
T7146	588-589	,	denotes	,
T7147	590-592	IN	denotes	as
T7148	593-595	PRP	denotes	it
T7149	596-599	VBD	denotes	was
T7150	600-610	RB	denotes	previously
T7151	611-619	VBN	denotes	observed
T7152	620-621	NNP	denotes	[
T7153	621-622	CD	denotes	3
T7154	622-623	NNP	denotes	]
T7155	623-624	.	denotes	.
T7156	625-632	RB	denotes	However
T7157	632-633	,	denotes	,
T7158	634-636	IN	denotes	at
T7159	637-640	JJ	denotes	low
T7160	641-654	NN	denotes	concentration
T7161	654-655	,	denotes	,
T7162	656-660	NN	denotes	IL-4
T7163	661-664	VBD	denotes	was
T7164	665-669	JJ	denotes	able
T7165	670-672	TO	denotes	to
T7166	673-683	RB	denotes	marginally
T7167	684-690	VB	denotes	induce
T7168	691-696	CD	denotes	FOXP3
T7169	697-707	NN	denotes	expression
T7170	707-708	.	denotes	.
T7171	709-711	IN	denotes	Of
T7172	712-716	NN	denotes	note
T7173	716-717	,	denotes	,
T7174	718-723	NNP	denotes	GATA3
T7175	724-727	VBD	denotes	was
T7176	728-732	RB	denotes	also
T7177	733-740	VBN	denotes	induced
T7178	741-743	IN	denotes	in
T7179	744-747	DT	denotes	the
T7180	748-756	NN	denotes	presence
T7181	757-759	IN	denotes	of
T7182	760-765	NNP	denotes	TGF-β
T7183	766-768	IN	denotes	at
T7184	769-773	JJ	denotes	high
T7185	774-778	NN	denotes	IL-4
T7186	779-792	NN	denotes	concentration
T7187	793-794	-LRB-	denotes	(
T7188	794-800	NN	denotes	Figure
T7189	801-803	NN	denotes	5A
T7190	804-807	CC	denotes	and
T7191	808-810	NN	denotes	5B
T7192	810-811	-RRB-	denotes	)
T7193	811-812	.	denotes	.
T7194	813-816	DT	denotes	The
T7195	817-821	NN	denotes	IL-4
T7196	822-830	VBN	denotes	mediated
T7197	831-841	NN	denotes	prevention
T7198	842-844	IN	denotes	of
T7199	845-850	CD	denotes	FOXP3
T7200	851-861	NN	denotes	expression
T7201	862-865	VBD	denotes	was
T7202	866-869	RB	denotes	not
T7203	870-876	VBN	denotes	caused
T7204	877-879	IN	denotes	by
T7205	880-893	NNS	denotes	interferences
T7206	894-896	IN	denotes	of
T7207	897-900	DT	denotes	the
T7208	901-909	NN	denotes	receptor
T7209	910-919	VBG	denotes	signaling
T7210	919-920	,	denotes	,
T7211	921-928	IN	denotes	because
T7212	929-932	DT	denotes	the
T7213	933-948	NN	denotes	phosphorylation
T7214	949-951	IN	denotes	of
T7215	952-957	CD	denotes	SMAD2
T7216	958-960	CC	denotes	or
T7217	961-966	CD	denotes	STAT6
T7218	967-970	VBD	denotes	was
T7219	971-974	RB	denotes	not
T7220	975-983	VBN	denotes	affected
T7221	984-986	IN	denotes	by
T7222	987-990	DT	denotes	the
T7223	991-999	NN	denotes	addition
T7224	1000-1002	IN	denotes	of
T7225	1003-1007	NN	denotes	IL-4
T7226	1008-1014	CC	denotes	and/or
T7227	1015-1020	NN	denotes	TGF-β
T7228	1020-1021	,	denotes	,
T7229	1022-1027	WDT	denotes	which
T7230	1028-1040	VBZ	denotes	demonstrates
T7231	1041-1045	IN	denotes	that
T7232	1046-1050	NN	denotes	IL-4
T7233	1051-1053	RB	denotes	as
T7234	1054-1058	RB	denotes	well
T7235	1059-1061	IN	denotes	as
T7236	1062-1067	JJ	denotes	TGF-β
T7237	1068-1077	VBG	denotes	signaling
T7238	1078-1082	VBD	denotes	were
T7239	1083-1093	JJ	denotes	functional
T7240	1094-1099	IN	denotes	under
T7241	1100-1105	DT	denotes	these
T7242	1106-1116	NNS	denotes	conditions
T7243	1117-1118	-LRB-	denotes	(
T7244	1118-1124	NN	denotes	Figure
T7245	1125-1127	NN	denotes	5C
T7246	1127-1128	-RRB-	denotes	)
T7247	1128-1129	.	denotes	.
T7248	1130-1140	VBG	denotes	Increasing
T7249	1141-1148	NNS	denotes	amounts
T7250	1149-1151	IN	denotes	of
T7251	1152-1156	NN	denotes	IL-4
T7252	1157-1165	NN	denotes	increase
T7253	1166-1179	JJ	denotes	intracellular
T7254	1180-1185	NNP	denotes	GATA3
T7255	1185-1186	,	denotes	,
T7256	1187-1194	IN	denotes	whereas
T7257	1195-1200	CD	denotes	FOXP3
T7258	1201-1210	VBD	denotes	decreased
T7259	1210-1211	,	denotes	,
T7260	1212-1217	WDT	denotes	which
T7261	1218-1220	VBZ	denotes	is
T7262	1221-1231	JJ	denotes	consistent
T7263	1232-1236	IN	denotes	with
T7264	1237-1240	DT	denotes	the
T7265	1241-1245	NNP	denotes	mRNA
T7266	1246-1254	NN	denotes	analysis
T7267	1255-1256	-LRB-	denotes	(
T7268	1256-1262	NN	denotes	Figure
T7269	1263-1265	CD	denotes	5D
T7270	1265-1266	-RRB-	denotes	)
T7271	1266-1267	.	denotes	.
T7272	1268-1279	RB	denotes	Furthermore
T7273	1279-1280	,	denotes	,
T7274	1281-1290	NN	denotes	injection
T7275	1291-1293	IN	denotes	of
T7276	1294-1298	NN	denotes	IL-4
T7277	1299-1303	IN	denotes	into
T7278	1304-1313	JJ	denotes	wild-type
T7279	1314-1316	NNP	denotes	B6
T7280	1317-1321	NNS	denotes	mice
T7281	1322-1331	VBD	denotes	decreased
T7282	1332-1335	DT	denotes	the
T7283	1336-1345	JJ	denotes	inducible
T7284	1346-1348	CC	denotes	or
T7285	1349-1356	JJ	denotes	natural
T7286	1357-1361	NNP	denotes	Treg
T7287	1362-1368	NN	denotes	number
T7288	1369-1371	IN	denotes	in
T7289	1372-1376	NN	denotes	vivo
T7290	1376-1377	.	denotes	.
T7291	1378-1379	DT	denotes	A
T7292	1380-1391	NN	denotes	distinction
T7293	1392-1394	IN	denotes	of
T7294	1395-1398	DT	denotes	the
T7295	1399-1403	NNP	denotes	Treg
T7296	1404-1411	NNS	denotes	subsets
T7297	1412-1414	VBZ	denotes	is
T7298	1415-1418	RB	denotes	not
T7299	1419-1427	JJ	denotes	possible
T7300	1427-1428	,	denotes	,
T7301	1429-1436	IN	denotes	because
T7302	1437-1445	RB	denotes	recently
T7303	1446-1455	VBN	denotes	activated
T7304	1456-1461	NNP	denotes	iTreg
T7305	1462-1467	NNS	denotes	cells
T7306	1468-1472	RB	denotes	also
T7307	1473-1480	VBP	denotes	express
T7308	1481-1488	NN	denotes	surface
T7309	1489-1493	NNS	denotes	CD25
T7310	1493-1494	.	denotes	.
T7311	1495-1497	PRP	denotes	We
T7312	1498-1502	VBD	denotes	used
T7313	1503-1512	NNS	denotes	complexes
T7314	1513-1515	IN	denotes	of
T7315	1516-1527	JJ	denotes	recombinant
T7316	1528-1533	NN	denotes	mouse
T7317	1534-1538	NN	denotes	IL-4
T7318	1539-1540	-LRB-	denotes	(
T7319	1540-1546	NN	denotes	rmIL-4
T7320	1546-1547	-RRB-	denotes	)
T7321	1548-1552	CC	denotes	plus
T7322	1553-1562	JJ	denotes	anti-IL-4
T7323	1563-1573	JJ	denotes	monoclonal
T7324	1574-1584	NNS	denotes	antibodies
T7325	1585-1586	-LRB-	denotes	(
T7326	1586-1590	NNS	denotes	mAbs
T7327	1590-1591	-RRB-	denotes	)
T7328	1591-1592	,	denotes	,
T7329	1593-1598	WDT	denotes	which
T7330	1599-1603	VBP	denotes	have
T7331	1604-1608	VBN	denotes	been
T7332	1609-1614	VBN	denotes	shown
T7333	1615-1617	TO	denotes	to
T7334	1618-1630	RB	denotes	dramatically
T7335	1631-1639	VB	denotes	increase
T7336	1640-1643	DT	denotes	the
T7337	1644-1651	NN	denotes	potency
T7338	1652-1654	IN	denotes	of
T7339	1655-1658	DT	denotes	the
T7340	1659-1667	NN	denotes	cytokine
T7341	1668-1670	IN	denotes	in
T7342	1671-1675	NN	denotes	vivo
T7343	1676-1677	NNP	denotes	[
T7344	1677-1679	CD	denotes	19
T7345	1679-1680	NNP	denotes	]
T7346	1680-1681	.	denotes	.
T7347	1682-1684	IN	denotes	In
T7348	1685-1690	DT	denotes	these
T7349	1691-1695	NNS	denotes	mice
T7350	1695-1696	,	denotes	,
T7351	1697-1700	DT	denotes	the
T7352	1701-1711	NN	denotes	percentage
T7353	1712-1714	IN	denotes	of
T7354	1715-1718	NNP	denotes	CD4
T7355	1718-1719	NNP	denotes	+
T7356	1719-1723	NNP	denotes	CD25
T7357	1723-1724	NN	denotes	+
T7358	1725-1728	CC	denotes	and
T7359	1729-1734	CD	denotes	FOXP3
T7360	1734-1735	CD	denotes	+
T7361	1736-1737	NNP	denotes	T
T7362	1738-1743	NNS	denotes	cells
T7363	1744-1756	RB	denotes	dramatically
T7364	1757-1766	VBD	denotes	decreased
T7365	1767-1771	WRB	denotes	when
T7366	1772-1775	DT	denotes	the
T7367	1776-1793	JJ	denotes	antibody-cytokine
T7368	1794-1800	JJ	denotes	immune
T7369	1801-1810	NNS	denotes	complexes
T7370	1811-1815	VBD	denotes	were
T7371	1816-1824	VBN	denotes	injected
T7372	1825-1826	-LRB-	denotes	(
T7373	1826-1832	NN	denotes	Figure
T7374	1833-1835	CD	denotes	S2
T7375	1835-1836	-RRB-	denotes	)
T7376	1836-1837	.	denotes	.
T7377	1838-1842	IN	denotes	Upon
T7378	1843-1857	NN	denotes	administration
T7379	1858-1860	IN	denotes	of
T7380	1861-1867	NN	denotes	rmIL-4
T7381	1868-1872	CC	denotes	plus
T7382	1873-1882	JJ	denotes	anti-IL-4
T7383	1883-1886	NNP	denotes	mAb
T7384	1887-1896	NNS	denotes	complexes
T7385	1896-1897	,	denotes	,
T7386	1898-1901	DT	denotes	the
T7387	1902-1907	JJ	denotes	total
T7388	1908-1914	NN	denotes	number
T7389	1915-1917	IN	denotes	of
T7390	1918-1921	NNP	denotes	CD4
T7391	1921-1922	NNP	denotes	+
T7392	1922-1926	NNP	denotes	CD25
T7393	1926-1927	VBD	denotes	+
T7394	1928-1929	NNP	denotes	T
T7395	1930-1934	NN	denotes	cell
T7396	1934-1935	,	denotes	,
T7397	1936-1938	RB	denotes	as
T7398	1939-1943	RB	denotes	well
T7399	1944-1946	IN	denotes	as
T7400	1947-1950	DT	denotes	the
T7401	1951-1956	JJ	denotes	Foxp3
T7402	1956-1957	NN	denotes	+
T7403	1958-1959	NNP	denotes	T
T7404	1960-1965	NNS	denotes	cells
T7405	1966-1976	VBN	denotes	diminished
T7406	1977-1979	IN	denotes	by
T7407	1980-1984	NN	denotes	half
T7408	1985-1986	-LRB-	denotes	(
T7409	1986-1992	NN	denotes	Figure
T7410	1993-1996	CD	denotes	S2G
T7411	1997-2000	CC	denotes	and
T7412	2001-2004	CD	denotes	S2H
T7413	2004-2005	-RRB-	denotes	)
T7414	2005-2006	,	denotes	,
T7415	2007-2017	VBG	denotes	confirming
T7416	2018-2022	IN	denotes	that
T7417	2023-2026	DT	denotes	the
T7418	2027-2032	JJR	denotes	lower
T7419	2033-2043	NN	denotes	percentage
T7420	2044-2047	VBD	denotes	was
T7421	2048-2051	RB	denotes	not
T7422	2052-2055	JJ	denotes	due
T7423	2056-2058	TO	denotes	to
T7424	2059-2061	DT	denotes	an
T7425	2062-2070	NN	denotes	increase
T7426	2071-2073	IN	denotes	in
T7427	2074-2077	DT	denotes	the
T7428	2078-2081	NNP	denotes	CD4
T7429	2081-2082	NNP	denotes	+
T7430	2082-2086	NNP	denotes	CD25
T7431	2088-2093	NNS	denotes	cells
T7432	2093-2094	,	denotes	,
T7433	2095-2098	CC	denotes	but
T7434	2099-2100	DT	denotes	a
T7435	2101-2105	JJ	denotes	real
T7436	2106-2114	NN	denotes	decrease
T7437	2115-2117	IN	denotes	of
T7438	2118-2121	NNP	denotes	CD4
T7439	2121-2122	NNP	denotes	+
T7440	2122-2126	NNP	denotes	CD25
T7441	2126-2127	VBD	denotes	+
T7442	2128-2129	NNP	denotes	T
T7443	2130-2135	NNS	denotes	cells
T7444	2135-2136	.	denotes	.
T7445	2137-2139	IN	denotes	In
T7446	2140-2150	NN	denotes	conclusion
T7447	2150-2151	,	denotes	,
T7448	2152-2156	NN	denotes	IL-4
T7449	2157-2167	RB	denotes	negatively
T7450	2168-2177	VBZ	denotes	regulates
T7451	2178-2181	DT	denotes	the
T7452	2182-2189	JJ	denotes	natural
T7453	2190-2192	CC	denotes	or
T7454	2193-2202	JJ	denotes	inducible
T7455	2203-2207	NNP	denotes	Treg
T7456	2208-2212	NN	denotes	cell
T7457	2213-2221	NN	denotes	turnover
T7458	2222-2225	RB	denotes	not
T7459	2226-2230	RB	denotes	only
T7460	2231-2233	IN	denotes	in
T7461	2234-2239	NN	denotes	vitro
T7462	2240-2243	CC	denotes	but
T7463	2244-2248	RB	denotes	also
T7464	2249-2251	IN	denotes	in
T7465	2252-2256	NN	denotes	vivo
T7466	2256-2257	.	denotes	.
T7467	2258-2260	TO	denotes	To
T7468	2261-2266	VB	denotes	study
T7469	2267-2270	DT	denotes	the
T7470	2271-2278	NNS	denotes	effects
T7471	2279-2281	IN	denotes	of
T7472	2282-2286	NN	denotes	IL-4
T7473	2287-2289	IN	denotes	on
T7474	2290-2306	JJ	denotes	already-existing
T7475	2307-2312	JJ	denotes	human
T7476	2313-2320	JJ	denotes	natural
T7477	2321-2323	CC	denotes	or
T7478	2324-2333	JJ	denotes	inducible
T7479	2334-2338	NNP	denotes	Treg
T7480	2339-2344	NNS	denotes	cells
T7481	2344-2345	,	denotes	,
T7482	2346-2348	PRP	denotes	we
T7483	2349-2356	VBD	denotes	exposed
T7484	2357-2363	VBN	denotes	sorted
T7485	2364-2368	NNP	denotes	CD25
T7486	2368-2369	CD	denotes	+
T7487	2370-2371	NNP	denotes	T
T7488	2372-2377	NNS	denotes	cells
T7489	2378-2379	-LRB-	denotes	(
T7490	2379-2384	JJ	denotes	nTreg
T7491	2385-2390	NNS	denotes	cells
T7492	2390-2391	-RRB-	denotes	)
T7493	2392-2394	TO	denotes	to
T7494	2395-2399	NN	denotes	IL-4
T7495	2400-2403	CC	denotes	and
T7496	2404-2412	VBD	denotes	analyzed
T7497	2413-2418	CD	denotes	FOXP3
T7498	2419-2429	NN	denotes	expression
T7499	2430-2433	CC	denotes	and
T7500	2434-2445	JJ	denotes	suppressive
T7501	2446-2454	NN	denotes	capacity
T7502	2454-2455	.	denotes	.
T7503	2456-2458	IN	denotes	In
T7504	2459-2475	JJ	denotes	already-existing
T7505	2476-2480	NNP	denotes	Treg
T7506	2481-2486	NNS	denotes	cells
T7507	2486-2487	,	denotes	,
T7508	2488-2492	NN	denotes	IL-4
T7509	2493-2499	VBD	denotes	failed
T7510	2500-2502	TO	denotes	to
T7511	2503-2510	VB	denotes	inhibit
T7512	2511-2516	CD	denotes	FOXP3
T7513	2517-2527	NN	denotes	expression
T7514	2528-2529	-LRB-	denotes	(
T7515	2529-2535	NN	denotes	Figure
T7516	2536-2539	CD	denotes	S3A
T7517	2539-2540	-RRB-	denotes	)
T7518	2540-2541	,	denotes	,
T7519	2542-2545	CC	denotes	and
T7520	2546-2549	DT	denotes	the
T7521	2550-2561	JJ	denotes	suppressive
T7522	2562-2570	NN	denotes	capacity
T7523	2571-2574	VBD	denotes	was
T7524	2575-2578	RB	denotes	not
T7525	2579-2586	VBN	denotes	altered
T7526	2587-2588	-LRB-	denotes	(
T7527	2588-2594	NN	denotes	Figure
T7528	2595-2598	CD	denotes	S3C
T7529	2598-2599	-RRB-	denotes	)
T7530	2599-2600	.	denotes	.
T7531	2601-2610	RB	denotes	Similarly
T7532	2611-2623	JJ	denotes	pre-existing
T7533	2624-2629	NNP	denotes	iTreg
T7534	2630-2635	NNS	denotes	cells
T7535	2636-2639	VBD	denotes	did
T7536	2640-2643	RB	denotes	not
T7537	2644-2652	VB	denotes	decrease
T7538	2653-2658	CD	denotes	FOXP3
T7539	2659-2669	NN	denotes	expression
T7540	2670-2674	IN	denotes	upon
T7541	2675-2679	NN	denotes	IL-4
T7542	2680-2688	NN	denotes	exposure
T7543	2689-2690	-LRB-	denotes	(
T7544	2690-2696	NN	denotes	Figure
T7545	2697-2700	CD	denotes	S3B
T7546	2700-2701	-RRB-	denotes	)
T7547	2701-2702	.	denotes	.
T25390	2713-2719	NN	denotes	Effect
T25391	2720-2722	IN	denotes	of
T25392	2723-2727	NN	denotes	IL-4
T25393	2728-2730	IN	denotes	on
T25394	2731-2736	NNP	denotes	FOXP3
T25395	2737-2746	NNP	denotes	Induction
T25396	2747-2748	-LRB-	denotes	(
T25397	2748-2749	NNP	denotes	A
T25398	2749-2750	-RRB-	denotes	)
T25399	2751-2752	DT	denotes	A
T25400	2753-2764	JJ	denotes	statistical
T25401	2765-2773	NN	denotes	analysis
T25402	2774-2777	VBD	denotes	was
T25403	2778-2787	VBN	denotes	performed
T25404	2788-2792	IN	denotes	with
T25405	2793-2796	CD	denotes	six
T25406	2797-2803	NNS	denotes	donors
T25407	2804-2806	IN	denotes	on
T25408	2807-2810	NN	denotes	day
T25409	2811-2812	CD	denotes	5
T25410	2813-2814	-LRB-	denotes	(
T25411	2814-2819	NN	denotes	TGF-β
T25412	2820-2821	-LRB-	denotes	(
T25413	2821-2823	CD	denotes	10
T25414	2824-2829	NN	denotes	ng/ml
T25415	2829-2830	-RRB-	denotes	)
T25416	2831-2834	CC	denotes	and
T25417	2835-2839	IN	denotes	with
T25418	2840-2842	CC	denotes	or
T25419	2843-2850	IN	denotes	without
T25420	2851-2855	NN	denotes	IL-4
T25421	2856-2857	-LRB-	denotes	(
T25422	2857-2860	CD	denotes	100
T25423	2861-2866	NN	denotes	ng/ml
T25424	2866-2867	-RRB-	denotes	)
T25425	2867-2868	-RRB-	denotes	)
T25426	2868-2869	:	denotes	;
T25427	2870-2875	VBN	denotes	Shown
T25428	2876-2878	VBZ	denotes	is
T25429	2879-2882	DT	denotes	the
T25430	2883-2887	NN	denotes	mean
T25431	2887-2888	,	denotes	,
T25432	2889-2892	CC	denotes	and
T25433	2893-2898	NN	denotes	error
T25434	2899-2903	NNS	denotes	bars
T25435	2904-2913	VBD	denotes	indicated
T25436	2914-2917	DT	denotes	the
T25437	2918-2920	NNP	denotes	SD
T25438	2921-2923	IN	denotes	of
T25439	2924-2927	CD	denotes	six
T25440	2928-2934	NNS	denotes	donors
T25441	2934-2935	.	denotes	.
T25442	2936-2947	NNP	denotes	Statistical
T25443	2948-2956	NN	denotes	analysis
T25444	2957-2960	VBD	denotes	was
T25445	2961-2970	VBN	denotes	performed
T25446	2971-2976	VBG	denotes	using
T25447	2977-2980	DT	denotes	the
T25448	2981-2988	NNP	denotes	Dunnett
T25449	2989-2993	NN	denotes	test
T25450	2993-2994	.	denotes	.
T25451	2995-3006	NNP	denotes	Statistical
T25452	3007-3019	NN	denotes	significance
T25453	3020-3022	VBZ	denotes	is
T25454	3023-3032	VBN	denotes	indicated
T25455	3033-3035	IN	denotes	by
T25456	3036-3045	NNS	denotes	asterisks
T25457	3046-3047	-LRB-	denotes	(
T25458	3047-3048	SYM	denotes	*
T25459	3048-3049	FW	denotes	p
T25460	3050-3051	FW	denotes	≤
T25461	3052-3056	CD	denotes	0.05
T25462	3056-3057	,	denotes	,
T25463	3058-3060	SYM	denotes	**
T25464	3060-3061	FW	denotes	p
T25465	3062-3063	FW	denotes	≤
T25466	3064-3068	CD	denotes	0.01
T25467	3068-3069	,	denotes	,
T25468	3070-3077	NNP	denotes	Dunnett
T25469	3077-3078	-RRB-	denotes	)
T25470	3078-3079	.	denotes	.
T25471	3080-3081	-LRB-	denotes	(
T25472	3081-3082	NNP	denotes	B
T25473	3082-3083	-RRB-	denotes	)
T25474	3084-3087	NNP	denotes	CD4
T25475	3087-3088	NNP	denotes	+
T25476	3088-3094	NNP	denotes	CD45RA
T25477	3094-3095	VBD	denotes	+
T25478	3096-3101	NNS	denotes	cells
T25479	3102-3106	VBD	denotes	were
T25480	3107-3116	VBN	denotes	activated
T25481	3117-3119	IN	denotes	in
T25482	3120-3123	DT	denotes	the
T25483	3124-3132	NN	denotes	presence
T25484	3133-3135	IN	denotes	of
T25485	3136-3137	DT	denotes	a
T25486	3138-3146	JJ	denotes	constant
T25487	3147-3160	NN	denotes	concentration
T25488	3161-3163	IN	denotes	of
T25489	3164-3169	NNP	denotes	TGF-β
T25490	3170-3171	-LRB-	denotes	(
T25491	3171-3172	CD	denotes	5
T25492	3173-3178	NN	denotes	ng/ml
T25493	3178-3179	-RRB-	denotes	)
T25494	3180-3184	IN	denotes	with
T25495	3185-3187	DT	denotes	an
T25496	3188-3198	VBG	denotes	increasing
T25497	3199-3212	NN	denotes	concentration
T25498	3213-3215	IN	denotes	of
T25499	3216-3220	NN	denotes	IL-4
T25500	3220-3221	,	denotes	,
T25501	3222-3224	IN	denotes	as
T25502	3225-3234	VBN	denotes	indicated
T25503	3234-3235	.	denotes	.
T25504	3236-3241	NNS	denotes	Cells
T25505	3242-3246	VBD	denotes	were
T25506	3247-3256	VBN	denotes	harvested
T25507	3257-3260	IN	denotes	for
T25508	3261-3265	NNP	denotes	mRNA
T25509	3266-3280	NN	denotes	quantification
T25510	3281-3286	IN	denotes	after
T25511	3287-3288	CD	denotes	5
T25512	3289-3291	NN	denotes	d.
T25513	3292-3293	-LRB-	denotes	(
T25514	3293-3294	NNP	denotes	C
T25515	3294-3295	-RRB-	denotes	)
T25516	3296-3299	NNP	denotes	CD4
T25517	3299-3300	NNP	denotes	+
T25518	3300-3306	NNP	denotes	CD45RA
T25519	3306-3307	VBD	denotes	+
T25520	3308-3313	NNS	denotes	cells
T25521	3314-3318	VBD	denotes	were
T25522	3319-3329	VBN	denotes	stimulated
T25523	3330-3332	IN	denotes	in
T25524	3333-3338	NN	denotes	vitro
T25525	3339-3343	IN	denotes	with
T25526	3344-3355	JJ	denotes	plate-bound
T25527	3356-3364	JJ	denotes	anti-CD3
T25528	3364-3365	NN	denotes	/
T25529	3365-3369	NNP	denotes	CD28
T25530	3369-3370	,	denotes	,
T25531	3371-3376	NNP	denotes	TGF-β
T25532	3377-3378	-LRB-	denotes	(
T25533	3378-3385	CD	denotes	10ng/ml
T25534	3385-3386	-RRB-	denotes	)
T25535	3386-3387	,	denotes	,
T25536	3388-3391	CC	denotes	and
T25537	3392-3396	NN	denotes	IL-4
T25538	3397-3398	-LRB-	denotes	(
T25539	3398-3401	CD	denotes	100
T25540	3402-3407	NN	denotes	ng/ml
T25541	3407-3408	-RRB-	denotes	)
T25542	3409-3411	IN	denotes	as
T25543	3412-3421	VBN	denotes	indicated
T25544	3421-3422	.	denotes	.
T25545	3423-3428	IN	denotes	After
T25546	3429-3430	CD	denotes	1
T25547	3431-3432	NN	denotes	h
T25548	3432-3433	,	denotes	,
T25549	3434-3438	NN	denotes	cell
T25550	3439-3446	NNS	denotes	lysates
T25551	3447-3451	VBD	denotes	were
T25552	3452-3460	VBN	denotes	prepared
T25553	3461-3464	CC	denotes	and
T25554	3465-3473	VBN	denotes	analyzed
T25555	3474-3476	IN	denotes	by
T25556	3477-3484	JJ	denotes	Western
T25557	3485-3489	NN	denotes	blot
T25558	3490-3493	IN	denotes	for
T25559	3494-3508	VBN	denotes	phosphorylated
T25560	3509-3514	NNP	denotes	SMAD2
T25561	3515-3518	CC	denotes	and
T25562	3519-3524	NNP	denotes	STAT6
T25563	3524-3525	.	denotes	.
T25564	3526-3531	JJ	denotes	Total
T25565	3532-3537	NNP	denotes	STAT6
T25566	3538-3541	CC	denotes	and
T25567	3542-3547	NNP	denotes	GAPDH
T25568	3548-3554	VBD	denotes	served
T25569	3555-3557	IN	denotes	as
T25570	3558-3566	JJ	denotes	internal
T25571	3567-3574	NN	denotes	control
T25572	3574-3575	.	denotes	.
T25573	3576-3577	-LRB-	denotes	(
T25574	3577-3578	NNP	denotes	D
T25575	3578-3579	-RRB-	denotes	)
T25576	3580-3593	NNP	denotes	Intracellular
T25577	3594-3599	NNP	denotes	GATA3
T25578	3600-3603	CC	denotes	and
T25579	3604-3609	NNP	denotes	FOXP3
T25580	3610-3618	VBG	denotes	staining
T25581	3619-3622	VBP	denotes	are
T25582	3623-3628	VBN	denotes	shown
T25583	3629-3634	IN	denotes	after
T25584	3635-3643	NN	denotes	exposure
T25585	3644-3646	IN	denotes	of
T25586	3647-3650	NNP	denotes	CD4
T25587	3650-3651	NNP	denotes	+
T25588	3651-3657	NNP	denotes	CD45RA
T25589	3657-3658	VBD	denotes	+
T25590	3659-3660	NNP	denotes	T
T25591	3661-3666	NNS	denotes	cells
T25592	3667-3669	TO	denotes	to
T25593	3670-3674	NN	denotes	IL-4
T25594	3675-3677	IN	denotes	as
T25595	3678-3687	VBN	denotes	described
T25596	3688-3691	IN	denotes	for
T25597	3692-3697	NN	denotes	panel
T25598	3698-3700	NNP	denotes	B.
T25599	3701-3705	NNP	denotes	Data
T25600	3706-3709	VBP	denotes	are
T25601	3710-3724	JJ	denotes	representative
T25602	3725-3727	IN	denotes	of
T25603	3728-3733	CD	denotes	three
T25604	3734-3745	JJ	denotes	independent
T25605	3746-3757	NNS	denotes	experiments
T25606	3757-3758	.	denotes	.
R5399	T7041	T7042	nsubj	IL-4,Inhibits
R5401	T7042	T7042	ROOT	Inhibits,Inhibits
R5402	T7043	T7045	compound	TGF-β-Mediated,Commitment
R5403	T7044	T7045	compound	iTreg,Commitment
R5404	T7045	T7046	compound	Commitment,IL-4
R5405	T7046	T7047	nsubj	IL-4,induces
R5406	T7047	T7042	advcl	induces,Inhibits
R5407	T7048	T7047	dobj	differentiation,induces
R5408	T7049	T7048	prep	of,differentiation
R5409	T7050	T7052	amod	naive,cells
R5410	T7051	T7052	compound	T,cells
R5411	T7052	T7049	pobj	cells,of
R5412	T7053	T7047	punct	",",induces
R5413	T7054	T7047	prep	upon,induces
R5414	T7055	T7056	compound	antigen,encounter
R5415	T7056	T7054	pobj	encounter,upon
R5416	T7057	T7047	punct	",",induces
R5417	T7058	T7047	prep	into,induces
R5418	T7059	T7062	det	the,lineage
R5419	T7060	T7062	compound	Th2,lineage
R5420	T7079	T7077	pobj	priming,during
R5421	T7061	T7062	compound	cell,lineage
R5422	T7080	T7079	prep	of,priming
R5423	T7081	T7083	amod	naive,cells
R5424	T7082	T7083	compound	T,cells
R5425	T7062	T7058	pobj	lineage,into
R5426	T7083	T7080	pobj	cells,of
R5427	T7084	T7066	punct	.,asked
R5428	T7085	T7086	compound	Human,CD4
R5429	T7063	T7042	punct	.,Inhibits
R5430	T7086	T7093	nsubjpass	CD4,activated
R5431	T7087	T7093	nsubjpass	+,activated
R5432	T7088	T7089	nsubj	CD45RA,+
R5433	T7089	T7093	advmod	+,activated
R5434	T7064	T7066	nsubj	We,asked
R5435	T7065	T7066	advmod	therefore,asked
R5436	T7090	T7091	compound	T,cells
R5437	T7066	T7066	ROOT	asked,asked
R5438	T7067	T7069	mark	whether,is
R5440	T7068	T7069	nsubj	IL-4,is
R5443	T7094	T7093	prep	with,activated
R5444	T7069	T7066	ccomp	is,asked
R5445	T7095	T7097	nmod	plate-bound,/
R5446	T7096	T7097	compound	anti-CD3,/
R5447	T7097	T7094	pobj	/,with
R5448	T7070	T7069	acomp	able,is
R5449	T7098	T7097	nummod	CD28,/
R5450	T7099	T7093	prep	in,activated
R5451	T7100	T7101	det	the,presence
R5452	T7071	T7072	aux	to,inhibit
R5453	T7101	T7099	pobj	presence,in
R5454	T7102	T7101	prep	of,presence
R5455	T7072	T7070	xcomp	inhibit,able
R5456	T7103	T7102	pobj	TGF-β,of
R5457	T7104	T7101	cc	and/or,presence
R5458	T7105	T7101	conj	IL-4,presence
R5459	T7073	T7074	amod	TGF-β,induction
R5460	T7106	T7105	cc	and,IL-4
R5461	T7107	T7093	conj	harvested,activated
R5462	T7108	T7113	mark	after,repressed
R5463	T7074	T7072	dobj	induction,inhibit
R5464	T7109	T7111	nummod	5,IL-4
R5465	T7110	T7111	compound	d.,IL-4
R5466	T7111	T7113	nsubj	IL-4,repressed
R5467	T7112	T7113	advmod	efficiently,repressed
R5468	T7075	T7074	prep	of,induction
R5469	T7113	T7107	advcl	repressed,harvested
R5470	T7114	T7115	det	the,TGF-β
R5471	T7115	T7113	dobj	TGF-β,repressed
R5472	T7076	T7075	pobj	FOXP3,of
R5473	T7116	T7093	conj	mediated,activated
R5474	T7077	T7072	prep	during,inhibit
R5475	T7117	T7116	dobj	induction,mediated
R5476	T7118	T7117	prep	of,induction
R5477	T7119	T7120	nummod	FOXP3,expression
R5478	T7120	T7118	pobj	expression,of
R5479	T7078	T7079	det	the,priming
R5480	T7121	T7123	punct	(,5A
R5481	T7179	T7180	det	the,presence
R5482	T7122	T7123	nmod	Figure,5A
R5483	T7123	T7120	appos	5A,expression
R5484	T7180	T7178	pobj	presence,in
R5485	T7124	T7123	punct	),5A
R5486	T7125	T7116	prep	in,mediated
R5487	T7126	T7128	det	a,manner
R5488	T7127	T7128	amod	concentration-dependent,manner
R5489	T7181	T7180	prep	of,presence
R5490	T7128	T7125	pobj	manner,in
R5491	T7129	T7131	punct	(,5B
R5492	T7130	T7131	compound	Figure,5B
R5493	T7131	T7128	appos	5B,manner
R5494	T7132	T7131	punct	),5B
R5495	T7133	T7116	punct	.,mediated
R5496	T7182	T7181	pobj	TGF-β,of
R5497	T7134	T7135	amod	Low,levels
R5498	T7135	T7139	nsubjpass	levels,induced
R5499	T7136	T7135	prep	of,levels
R5500	T7137	T7136	pobj	GATA3,of
R5501	T7183	T7180	prep	at,presence
R5502	T7138	T7139	auxpass	were,induced
R5503	T7139	T7139	ROOT	induced,induced
R5504	T7140	T7139	advmod	also,induced
R5505	T7184	T7186	amod	high,concentration
R5506	T7141	T7139	prep	in,induced
R5507	T7142	T7143	det	the,absence
R5508	T7143	T7141	pobj	absence,in
R5509	T7185	T7186	compound	IL-4,concentration
R5510	T7144	T7143	prep	of,absence
R5511	T7145	T7144	pobj	IL-4,of
R5512	T7146	T7139	punct	",",induced
R5513	T7186	T7183	pobj	concentration,at
R5514	T7147	T7151	mark	as,observed
R5515	T7148	T7151	nsubjpass	it,observed
R5516	T7149	T7151	auxpass	was,observed
R5517	T7187	T7189	punct	(,5A
R5518	T7150	T7151	advmod	previously,observed
R5519	T7151	T7139	advcl	observed,induced
R5520	T7152	T7154	nmod	[,]
R5521	T7188	T7189	compound	Figure,5A
R5522	T7153	T7154	nummod	3,]
R5523	T7154	T7151	dobj	],observed
R5524	T7189	T7186	appos	5A,concentration
R5525	T7155	T7139	punct	.,induced
R5526	T7156	T7163	advmod	However,was
R5527	T7157	T7163	punct	",",was
R5528	T7190	T7189	cc	and,5A
R5529	T7158	T7163	prep	at,was
R5530	T7159	T7160	amod	low,concentration
R5531	T7160	T7158	pobj	concentration,at
R5532	T7191	T7189	conj	5B,5A
R5533	T7161	T7163	punct	",",was
R5534	T7162	T7163	nsubj	IL-4,was
R5535	T7163	T7163	ROOT	was,was
R5536	T7164	T7163	acomp	able,was
R5537	T7192	T7189	punct	),5A
R5538	T7165	T7167	aux	to,induce
R5539	T7166	T7167	advmod	marginally,induce
R5540	T7167	T7164	xcomp	induce,able
R5541	T7193	T7177	punct	.,induced
R5542	T7168	T7169	nummod	FOXP3,expression
R5543	T7194	T7195	det	The,IL-4
R5544	T7169	T7167	dobj	expression,induce
R5545	T7170	T7163	punct	.,was
R5546	T7171	T7177	prep	Of,induced
R5547	T7195	T7203	nsubjpass	IL-4,caused
R5548	T7172	T7171	pobj	note,Of
R5549	T7196	T7203	nsubjpass	mediated,caused
R5550	T7173	T7177	punct	",",induced
R5551	T7174	T7177	nsubjpass	GATA3,induced
R5552	T7175	T7177	auxpass	was,induced
R5553	T7197	T7196	dobj	prevention,mediated
R5554	T7176	T7177	advmod	also,induced
R5555	T7177	T7177	ROOT	induced,induced
R5556	T7178	T7177	prep	in,induced
R5557	T7198	T7197	prep	of,prevention
R5558	T7199	T7200	nummod	FOXP3,expression
R5559	T7200	T7198	pobj	expression,of
R5560	T7201	T7203	auxpass	was,caused
R5561	T7202	T7203	neg	not,caused
R5562	T7203	T7203	ROOT	caused,caused
R5563	T7276	T7275	pobj	IL-4,of
R5564	T7277	T7274	prep	into,injection
R5565	T7278	T7280	amod	wild-type,mice
R5566	T7204	T7203	agent	by,caused
R5567	T7279	T7280	compound	B6,mice
R5568	T7280	T7277	pobj	mice,into
R5569	T7205	T7204	pobj	interferences,by
R5570	T7281	T7281	ROOT	decreased,decreased
R5571	T7282	T7287	det	the,number
R5572	T7283	T7287	amod	inducible,number
R5573	T7206	T7205	prep	of,interferences
R5574	T7284	T7283	cc	or,inducible
R5575	T7285	T7283	conj	natural,inducible
R5576	T7286	T7287	compound	Treg,number
R5577	T7207	T7208	det	the,receptor
R5578	T7287	T7281	dobj	number,decreased
R5579	T7288	T7281	prep	in,decreased
R5580	T7289	T7288	pobj	vivo,in
R5581	T7208	T7206	pobj	receptor,of
R5582	T7290	T7281	punct	.,decreased
R5583	T7291	T7292	det	A,distinction
R5584	T7209	T7205	acl	signaling,interferences
R5585	T7292	T7297	nsubj	distinction,is
R5586	T7293	T7292	prep	of,distinction
R5587	T7294	T7296	det	the,subsets
R5588	T7210	T7203	punct	",",caused
R5589	T7295	T7296	compound	Treg,subsets
R5590	T7296	T7293	pobj	subsets,of
R5591	T7297	T7297	ROOT	is,is
R5592	T7211	T7220	mark	because,affected
R5593	T7298	T7297	neg	not,is
R5594	T7299	T7297	acomp	possible,is
R5595	T7300	T7297	punct	",",is
R5596	T7301	T7307	mark	because,express
R5597	T7302	T7303	advmod	recently,activated
R5598	T7303	T7305	amod	activated,cells
R5599	T7212	T7213	det	the,phosphorylation
R5600	T7304	T7305	compound	iTreg,cells
R5601	T7305	T7307	nsubj	cells,express
R5602	T7306	T7307	advmod	also,express
R5603	T7307	T7297	advcl	express,is
R5604	T7213	T7220	nsubjpass	phosphorylation,affected
R5605	T7308	T7309	compound	surface,CD25
R5606	T7309	T7307	dobj	CD25,express
R5607	T7310	T7297	punct	.,is
R5608	T7214	T7213	prep	of,phosphorylation
R5609	T7311	T7312	nsubj	We,used
R5610	T7312	T7312	ROOT	used,used
R5611	T7313	T7312	dobj	complexes,used
R5612	T7215	T7214	pobj	SMAD2,of
R5613	T7314	T7313	prep	of,complexes
R5614	T7315	T7317	amod	recombinant,IL-4
R5615	T7316	T7317	compound	mouse,IL-4
R5616	T7317	T7314	pobj	IL-4,of
R5617	T7216	T7215	cc	or,SMAD2
R5618	T7318	T7319	punct	(,rmIL-4
R5619	T7319	T7317	appos	rmIL-4,IL-4
R5620	T7320	T7319	punct	),rmIL-4
R5621	T7217	T7215	conj	STAT6,SMAD2
R5622	T7321	T7317	cc	plus,IL-4
R5623	T7322	T7324	amod	anti-IL-4,antibodies
R5624	T7323	T7324	amod	monoclonal,antibodies
R5625	T7218	T7220	auxpass	was,affected
R5626	T7324	T7317	conj	antibodies,IL-4
R5627	T7219	T7220	neg	not,affected
R5629	T7220	T7203	advcl	affected,caused
R5632	T7221	T7220	agent	by,affected
R5634	T7222	T7223	det	the,addition
R5635	T7329	T7332	nsubjpass	which,shown
R5636	T7223	T7221	pobj	addition,by
R5637	T7330	T7332	aux	have,shown
R5638	T7331	T7332	auxpass	been,shown
R5639	T7332	T7324	relcl	shown,antibodies
R5640	T7224	T7223	prep	of,addition
R5641	T7333	T7335	aux	to,increase
R5642	T7334	T7335	advmod	dramatically,increase
R5643	T7335	T7332	xcomp	increase,shown
R5644	T7225	T7224	pobj	IL-4,of
R5645	T7336	T7337	det	the,potency
R5646	T7337	T7335	dobj	potency,increase
R5647	T7338	T7337	prep	of,potency
R5648	T7339	T7340	det	the,cytokine
R5649	T7340	T7338	pobj	cytokine,of
R5650	T7226	T7225	cc	and/or,IL-4
R5651	T7341	T7340	prep	in,cytokine
R5652	T7342	T7343	compound	vivo,[
R5653	T7343	T7341	pobj	[,in
R5654	T7344	T7345	nummod	19,]
R5655	T7227	T7225	conj	TGF-β,IL-4
R5656	T7345	T7343	appos	],[
R5657	T7346	T7312	punct	.,used
R5658	T7228	T7225	punct	",",IL-4
R5659	T7347	T7364	prep	In,decreased
R5660	T7348	T7349	det	these,mice
R5661	T7349	T7347	pobj	mice,In
R5662	T7350	T7364	punct	",",decreased
R5663	T7229	T7230	nsubj	which,demonstrates
R5664	T7351	T7352	det	the,percentage
R5665	T7352	T7364	nsubj	percentage,decreased
R5666	T7353	T7352	prep	of,percentage
R5667	T7230	T7223	relcl	demonstrates,addition
R5668	T7354	T7357	compound	CD4,+
R5669	T7355	T7357	compound	+,+
R5670	T7356	T7357	compound	CD25,+
R5671	T7231	T7238	mark	that,were
R5672	T7357	T7352	conj	+,percentage
R5673	T7358	T7357	cc	and,+
R5674	T7359	T7362	nummod	FOXP3,cells
R5675	T7232	T7238	nsubj	IL-4,were
R5676	T7360	T7362	nummod	+,cells
R5677	T7361	T7362	compound	T,cells
R5678	T7362	T7364	nsubj	cells,decreased
R5679	T7233	T7235	advmod	as,as
R5680	T7363	T7364	advmod	dramatically,decreased
R5681	T7364	T7364	ROOT	decreased,decreased
R5682	T7365	T7371	advmod	when,injected
R5683	T7234	T7235	advmod	well,as
R5684	T7366	T7369	det	the,complexes
R5685	T7367	T7369	amod	antibody-cytokine,complexes
R5686	T7235	T7232	cc	as,IL-4
R5687	T7368	T7369	amod	immune,complexes
R5688	T7369	T7371	nsubjpass	complexes,injected
R5689	T7370	T7371	auxpass	were,injected
R5690	T7236	T7237	amod	TGF-β,signaling
R5691	T7371	T7364	advcl	injected,decreased
R5692	T7372	T7373	punct	(,Figure
R5693	T7237	T7232	conj	signaling,IL-4
R5694	T7238	T7230	ccomp	were,demonstrates
R5695	T7373	T7371	dep	Figure,injected
R5696	T7374	T7373	nummod	S2,Figure
R5697	T7239	T7238	acomp	functional,were
R5698	T7375	T7373	punct	),Figure
R5699	T7376	T7364	punct	.,decreased
R5700	T7377	T7377	ROOT	Upon,Upon
R5701	T7240	T7238	prep	under,were
R5702	T7378	T7377	pobj	administration,Upon
R5703	T7379	T7378	prep	of,administration
R5704	T7380	T7384	nmod	rmIL-4,complexes
R5705	T7241	T7242	det	these,conditions
R5706	T7381	T7380	cc	plus,rmIL-4
R5707	T7382	T7384	amod	anti-IL-4,complexes
R5708	T7383	T7384	compound	mAb,complexes
R5709	T7242	T7240	pobj	conditions,under
R5710	T7384	T7379	pobj	complexes,of
R5711	T7385	T7378	punct	",",administration
R5712	T7386	T7388	det	the,number
R5713	T7387	T7388	amod	total,number
R5714	T7243	T7245	punct	(,5C
R5715	T7388	T7377	dobj	number,Upon
R5716	T7389	T7388	prep	of,number
R5717	T7390	T7395	nmod	CD4,cell
R5718	T7244	T7245	compound	Figure,5C
R5719	T7391	T7395	nmod	+,cell
R5720	T7392	T7395	nmod	CD25,cell
R5721	T7393	T7395	amod	+,cell
R5722	T7245	T7242	appos	5C,conditions
R5723	T7394	T7395	compound	T,cell
R5724	T7395	T7389	pobj	cell,of
R5725	T7396	T7388	punct	",",number
R5726	T7246	T7220	punct	),affected
R5727	T7397	T7399	advmod	as,as
R5728	T7398	T7399	advmod	well,as
R5729	T7399	T7388	cc	as,number
R5730	T7247	T7203	punct	.,caused
R5731	T7248	T7249	amod	Increasing,amounts
R5732	T7400	T7404	det	the,cells
R5733	T7249	T7258	nsubj	amounts,decreased
R5734	T7401	T7404	amod	Foxp3,cells
R5735	T7402	T7404	amod	+,cells
R5736	T7250	T7249	prep	of,amounts
R5737	T7403	T7404	compound	T,cells
R5738	T7404	T7388	conj	cells,number
R5739	T7405	T7404	acl	diminished,cells
R5740	T7251	T7252	compound	IL-4,increase
R5741	T7406	T7405	agent	by,diminished
R5742	T7252	T7249	appos	increase,amounts
R5743	T7407	T7409	predet	half,Figure
R5744	T7253	T7254	compound	intracellular,GATA3
R5745	T7408	T7409	punct	(,Figure
R5746	T7409	T7406	pobj	Figure,by
R5747	T7410	T7409	nummod	S2G,Figure
R5748	T7411	T7409	cc	and,Figure
R5749	T7412	T7409	conj	S2H,Figure
R5750	T7413	T7409	punct	),Figure
R5751	T7254	T7252	appos	GATA3,increase
R5752	T7414	T7404	punct	",",cells
R5753	T7415	T7388	acl	confirming,number
R5754	T7416	T7420	mark	that,was
R5755	T7255	T7249	punct	",",amounts
R5756	T7417	T7419	det	the,percentage
R5757	T7418	T7419	amod	lower,percentage
R5758	T7419	T7420	nsubj	percentage,was
R5759	T7256	T7258	mark	whereas,decreased
R5760	T7420	T7415	ccomp	was,confirming
R5761	T7421	T7420	neg	not,was
R5762	T7422	T7420	acomp	due,was
R5763	T7257	T7258	nsubj	FOXP3,decreased
R5764	T7423	T7422	prep	to,due
R5765	T7424	T7425	det	an,increase
R5766	T7425	T7423	pobj	increase,to
R5767	T7258	T7258	ROOT	decreased,decreased
R5768	T7426	T7425	prep	in,increase
R5769	T7427	T7430	det	the,CD25
R5770	T7428	T7430	compound	CD4,CD25
R5771	T7259	T7258	punct	",",decreased
R5772	T7429	T7430	compound	+,CD25
R5773	T7430	T7426	pobj	CD25,in
R5774	T7431	T7420	npadvmod	cells,was
R5775	T7432	T7420	punct	",",was
R5776	T7260	T7261	nsubj	which,is
R5777	T7433	T7420	cc	but,was
R5778	T7434	T7436	det	a,decrease
R5779	T7435	T7436	amod	real,decrease
R5780	T7261	T7258	advcl	is,decreased
R5781	T7436	T7420	conj	decrease,was
R5782	T7437	T7436	prep	of,decrease
R5783	T7438	T7440	compound	CD4,CD25
R5784	T7439	T7440	compound	+,CD25
R5785	T7262	T7261	acomp	consistent,is
R5786	T7440	T7437	pobj	CD25,of
R5787	T7441	T7443	amod	+,cells
R5788	T7442	T7443	compound	T,cells
R5789	T7263	T7262	prep	with,consistent
R5790	T7443	T7436	conj	cells,decrease
R5791	T7444	T7377	punct	.,Upon
R5792	T7445	T7450	prep	In,regulates
R5793	T7264	T7266	det	the,analysis
R5794	T7446	T7445	pobj	conclusion,In
R5795	T7447	T7450	punct	",",regulates
R5796	T7448	T7450	nsubj	IL-4,regulates
R5797	T7449	T7450	advmod	negatively,regulates
R5798	T7450	T7450	ROOT	regulates,regulates
R5799	T7451	T7457	det	the,turnover
R5800	T7452	T7457	amod	natural,turnover
R5801	T7265	T7266	compound	mRNA,analysis
R5802	T7453	T7452	cc	or,natural
R5803	T7454	T7452	conj	inducible,natural
R5804	T7455	T7457	compound	Treg,turnover
R5805	T7266	T7263	pobj	analysis,with
R5806	T7456	T7457	compound	cell,turnover
R5807	T7457	T7450	dobj	turnover,regulates
R5808	T7458	T7460	preconj	not,in
R5809	T7459	T7458	advmod	only,not
R5810	T7267	T7268	punct	(,Figure
R5811	T7460	T7450	prep	in,regulates
R5812	T7461	T7460	pobj	vitro,in
R5813	T7462	T7460	cc	but,in
R5814	T7268	T7266	appos	Figure,analysis
R5815	T7463	T7462	advmod	also,but
R5816	T7464	T7460	conj	in,in
R5817	T7465	T7464	pobj	vivo,in
R5818	T7269	T7268	nummod	5D,Figure
R5819	T7466	T7450	punct	.,regulates
R5820	T7467	T7468	aux	To,study
R5821	T7468	T7483	advcl	study,exposed
R5822	T7270	T7268	punct	),Figure
R5823	T7469	T7470	det	the,effects
R5824	T7271	T7258	punct	.,decreased
R5825	T7272	T7281	advmod	Furthermore,decreased
R5826	T7470	T7468	dobj	effects,study
R5827	T7471	T7470	prep	of,effects
R5828	T7273	T7281	punct	",",decreased
R5829	T7472	T7471	pobj	IL-4,of
R5830	T7473	T7470	prep	on,effects
R5831	T7474	T7480	amod	already-existing,cells
R5832	T7274	T7281	nsubj	injection,decreased
R5833	T7475	T7476	amod	human,natural
R5834	T7476	T7480	amod	natural,cells
R5835	T7477	T7476	cc	or,natural
R5836	T7275	T7274	prep	of,injection
R5837	T7478	T7476	conj	inducible,natural
R5838	T7479	T7480	compound	Treg,cells
R5839	T7480	T7473	pobj	cells,on
R5841	T7481	T7483	punct	",",exposed
R5842	T7482	T7483	nsubj	we,exposed
R5843	T7483	T7483	ROOT	exposed,exposed
R5844	T7484	T7488	amod	sorted,cells
R5845	T7485	T7488	nmod	CD25,cells
R5846	T7486	T7488	nummod	+,cells
R5847	T7487	T7488	compound	T,cells
R5848	T7488	T7483	dobj	cells,exposed
R5849	T7489	T7488	punct	(,cells
R5850	T7490	T7491	amod	nTreg,cells
R5851	T7491	T7488	appos	cells,cells
R5852	T7492	T7488	punct	),cells
R5853	T7493	T7483	prep	to,exposed
R5855	T7494	T7493	pobj	IL-4,to
R5856	T7495	T7483	cc	and,exposed
R5857	T7496	T7483	conj	analyzed,exposed
R5858	T7497	T7498	nummod	FOXP3,expression
R5859	T7498	T7496	dobj	expression,analyzed
R5861	T7499	T7498	cc	and,expression
R5862	T7500	T7501	amod	suppressive,capacity
R5863	T7501	T7498	conj	capacity,expression
R5865	T7502	T7483	punct	.,exposed
R5866	T7503	T7509	prep	In,failed
R5867	T7504	T7506	amod	already-existing,cells
R5868	T7505	T7506	compound	Treg,cells
R5870	T7506	T7503	pobj	cells,In
R5871	T7507	T7509	punct	",",failed
R5872	T7508	T7509	nsubj	IL-4,failed
R5873	T7509	T7509	ROOT	failed,failed
R5874	T7510	T7511	aux	to,inhibit
R5875	T7511	T7509	xcomp	inhibit,failed
R5876	T7512	T7513	nummod	FOXP3,expression
R5877	T7513	T7511	dobj	expression,inhibit
R5878	T7514	T7515	punct	(,Figure
R5879	T7515	T7513	appos	Figure,expression
R5880	T7516	T7515	nummod	S3A,Figure
R5882	T7517	T7515	punct	),Figure
R5883	T7518	T7509	punct	",",failed
R5884	T7519	T7509	cc	and,failed
R5885	T7520	T7522	det	the,capacity
R5886	T7521	T7522	amod	suppressive,capacity
R5888	T7522	T7525	nsubjpass	capacity,altered
R5889	T7523	T7525	auxpass	was,altered
R5890	T7524	T7525	neg	not,altered
R5891	T7525	T7509	conj	altered,failed
R5893	T7526	T7525	punct	(,altered
R5894	T7527	T7529	nmod	Figure,)
R5895	T7528	T7527	nummod	S3C,Figure
R5896	T7529	T7525	punct	),altered
R5897	T7530	T7525	punct	.,altered
R5898	T7531	T7537	advmod	Similarly,decrease
R5899	T7532	T7534	amod	pre-existing,cells
R5901	T7533	T7534	compound	iTreg,cells
R5902	T7534	T7537	nsubj	cells,decrease
R5903	T7535	T7537	aux	did,decrease
R5904	T7536	T7537	neg	not,decrease
R5906	T7537	T7537	ROOT	decrease,decrease
R5907	T7538	T7539	nummod	FOXP3,expression
R5908	T7539	T7537	dobj	expression,decrease
R5909	T7540	T7539	prep	upon,expression
R5911	T7541	T7542	compound	IL-4,exposure
R5912	T7542	T7540	pobj	exposure,upon
R5913	T7543	T7544	punct	(,Figure
R5914	T7544	T7542	appos	Figure,exposure
R5915	T7545	T7544	nummod	S3B,Figure
R5917	T7546	T7544	punct	),Figure
R5918	T7547	T7537	punct	.,decrease
R18910	T25390	T25390	ROOT	Effect,Effect
R18911	T25391	T25390	prep	of,Effect
R18912	T25392	T25391	pobj	IL-4,of
R18913	T25393	T25390	prep	on,Effect
R18914	T25394	T25395	compound	FOXP3,Induction
R18915	T25395	T25393	pobj	Induction,on
R18916	T25396	T25395	punct	(,Induction
R18917	T25397	T25395	appos	A,Induction
R18918	T25398	T25395	punct	),Induction
R18919	T25399	T25401	det	A,analysis
R18920	T25400	T25401	amod	statistical,analysis
R18921	T25401	T25403	nsubjpass	analysis,performed
R18922	T25402	T25403	auxpass	was,performed
R18923	T25403	T25428	ccomp	performed,is
R18924	T25404	T25403	prep	with,performed
R18925	T25405	T25406	nummod	six,donors
R18926	T25406	T25404	pobj	donors,with
R18927	T25407	T25403	prep	on,performed
R18928	T25408	T25407	pobj	day,on
R18929	T25409	T25408	nummod	5,day
R18930	T25410	T25417	punct	(,with
R18931	T25411	T25417	amod	TGF-β,with
R18932	T25412	T25414	punct	(,ng/ml
R18933	T25413	T25414	nummod	10,ng/ml
R18934	T25414	T25411	appos	ng/ml,TGF-β
R18935	T25415	T25414	punct	),ng/ml
R18936	T25416	T25411	cc	and,TGF-β
R18937	T25417	T25403	prep	with,performed
R18938	T25418	T25417	cc	or,with
R18939	T25419	T25417	conj	without,with
R18940	T25420	T25419	pobj	IL-4,without
R18941	T25421	T25420	punct	(,IL-4
R18942	T25422	T25423	nummod	100,ng/ml
R18943	T25423	T25420	appos	ng/ml,IL-4
R18944	T25424	T25420	punct	),IL-4
R18945	T25425	T25417	punct	),with
R18946	T25426	T25428	punct	;,is
R18947	T25427	T25428	advmod	Shown,is
R18948	T25428	T25428	ROOT	is,is
R18949	T25429	T25430	det	the,mean
R18950	T25430	T25428	attr	mean,is
R18951	T25431	T25430	punct	",",mean
R18952	T25432	T25430	cc	and,mean
R18953	T25433	T25434	compound	error,bars
R18954	T25434	T25435	nsubj	bars,indicated
R18955	T25435	T25428	conj	indicated,is
R18956	T25436	T25437	det	the,SD
R18957	T25437	T25435	dobj	SD,indicated
R18958	T25438	T25437	prep	of,SD
R18959	T25439	T25440	nummod	six,donors
R18960	T25440	T25438	pobj	donors,of
R18961	T25441	T25435	punct	.,indicated
R18962	T25442	T25443	compound	Statistical,analysis
R18963	T25443	T25445	nsubjpass	analysis,performed
R18964	T25444	T25445	auxpass	was,performed
R18965	T25445	T25445	ROOT	performed,performed
R18966	T25446	T25445	advcl	using,performed
R18967	T25447	T25449	det	the,test
R18968	T25448	T25449	compound	Dunnett,test
R18969	T25449	T25446	dobj	test,using
R18970	T25450	T25445	punct	.,performed
R18971	T25451	T25452	compound	Statistical,significance
R18972	T25452	T25454	nsubjpass	significance,indicated
R18973	T25453	T25454	auxpass	is,indicated
R18974	T25454	T25454	ROOT	indicated,indicated
R18975	T25455	T25454	agent	by,indicated
R18976	T25456	T25455	pobj	asterisks,by
R18977	T25457	T25461	punct	(,0.05
R18978	T25458	T25461	punct	*,0.05
R18979	T25459	T25461	amod	p,0.05
R18980	T25460	T25461	compound	≤,0.05
R18981	T25461	T25456	appos	0.05,asterisks
R18982	T25462	T25461	punct	",",0.05
R18983	T25463	T25466	punct	**,0.01
R18984	T25464	T25466	amod	p,0.01
R18985	T25465	T25466	compound	≤,0.01
R18986	T25466	T25461	appos	0.01,0.05
R18987	T25467	T25461	punct	",",0.05
R18988	T25468	T25461	appos	Dunnett,0.05
R18989	T25469	T25461	punct	),0.05
R18990	T25470	T25454	punct	.,indicated
R18991	T25471	T25480	punct	(,activated
R18992	T25472	T25476	nmod	B,CD45RA
R18993	T25473	T25472	punct	),B
R18994	T25474	T25476	compound	CD4,CD45RA
R18995	T25475	T25476	compound	+,CD45RA
R18996	T25476	T25480	nsubjpass	CD45RA,activated
R18997	T25477	T25478	amod	+,cells
R18998	T25478	T25480	nsubjpass	cells,activated
R18999	T25479	T25480	auxpass	were,activated
R19000	T25480	T25480	ROOT	activated,activated
R19001	T25481	T25480	prep	in,activated
R19002	T25482	T25483	det	the,presence
R19003	T25483	T25481	pobj	presence,in
R19004	T25484	T25483	prep	of,presence
R19005	T25485	T25487	det	a,concentration
R19006	T25486	T25487	amod	constant,concentration
R19007	T25487	T25484	pobj	concentration,of
R19008	T25488	T25487	prep	of,concentration
R19009	T25489	T25488	pobj	TGF-β,of
R19010	T25490	T25492	punct	(,ng/ml
R19011	T25491	T25492	nummod	5,ng/ml
R19012	T25492	T25489	appos	ng/ml,TGF-β
R19013	T25493	T25489	punct	),TGF-β
R19014	T25494	T25487	prep	with,concentration
R19015	T25495	T25497	det	an,concentration
R19016	T25496	T25497	amod	increasing,concentration
R19017	T25497	T25494	pobj	concentration,with
R19018	T25498	T25497	prep	of,concentration
R19019	T25499	T25498	pobj	IL-4,of
R19020	T25500	T25480	punct	",",activated
R19021	T25501	T25502	mark	as,indicated
R19022	T25502	T25480	advcl	indicated,activated
R19023	T25503	T25480	punct	.,activated
R19024	T25504	T25506	nsubjpass	Cells,harvested
R19025	T25505	T25506	auxpass	were,harvested
R19026	T25506	T25506	ROOT	harvested,harvested
R19027	T25507	T25506	prep	for,harvested
R19028	T25508	T25509	compound	mRNA,quantification
R19029	T25509	T25507	pobj	quantification,for
R19030	T25510	T25506	prep	after,harvested
R19031	T25511	T25512	nummod	5,d.
R19032	T25512	T25510	pobj	d.,after
R19033	T25513	T25512	punct	(,d.
R19034	T25514	T25512	npadvmod	C,d.
R19035	T25515	T25514	punct	),C
R19036	T25516	T25518	compound	CD4,CD45RA
R19037	T25517	T25518	compound	+,CD45RA
R19038	T25518	T25522	nsubjpass	CD45RA,stimulated
R19039	T25519	T25520	amod	+,cells
R19040	T25520	T25522	nsubjpass	cells,stimulated
R19041	T25521	T25522	auxpass	were,stimulated
R19042	T25522	T25522	ROOT	stimulated,stimulated
R19043	T25523	T25522	prep	in,stimulated
R19044	T25524	T25523	pobj	vitro,in
R19045	T25525	T25524	prep	with,vitro
R19046	T25526	T25529	amod	plate-bound,CD28
R19047	T25527	T25528	amod	anti-CD3,/
R19048	T25528	T25529	compound	/,CD28
R19049	T25529	T25525	pobj	CD28,with
R19050	T25530	T25529	punct	",",CD28
R19051	T25531	T25529	conj	TGF-β,CD28
R19052	T25532	T25531	punct	(,TGF-β
R19053	T25533	T25531	parataxis	10ng/ml,TGF-β
R19054	T25534	T25531	punct	),TGF-β
R19055	T25535	T25522	punct	",",stimulated
R19056	T25536	T25522	cc	and,stimulated
R19057	T25537	T25522	conj	IL-4,stimulated
R19058	T25538	T25540	punct	(,ng/ml
R19059	T25539	T25540	nummod	100,ng/ml
R19060	T25540	T25537	appos	ng/ml,IL-4
R19061	T25541	T25537	punct	),IL-4
R19062	T25542	T25543	mark	as,indicated
R19063	T25543	T25522	conj	indicated,stimulated
R19064	T25544	T25522	punct	.,stimulated
R19065	T25545	T25552	prep	After,prepared
R19066	T25546	T25547	nummod	1,h
R19067	T25547	T25545	pobj	h,After
R19068	T25548	T25552	punct	",",prepared
R19069	T25549	T25550	compound	cell,lysates
R19070	T25550	T25552	nsubjpass	lysates,prepared
R19071	T25551	T25552	auxpass	were,prepared
R19072	T25552	T25552	ROOT	prepared,prepared
R19073	T25553	T25552	cc	and,prepared
R19074	T25554	T25552	conj	analyzed,prepared
R19075	T25555	T25554	agent	by,analyzed
R19076	T25556	T25557	amod	Western,blot
R19077	T25557	T25555	pobj	blot,by
R19078	T25558	T25554	prep	for,analyzed
R19079	T25559	T25560	compound	phosphorylated,SMAD2
R19080	T25560	T25558	pobj	SMAD2,for
R19081	T25561	T25560	cc	and,SMAD2
R19082	T25562	T25560	conj	STAT6,SMAD2
R19083	T25563	T25552	punct	.,prepared
R19084	T25564	T25565	compound	Total,STAT6
R19085	T25565	T25568	nsubj	STAT6,served
R19086	T25566	T25565	cc	and,STAT6
R19087	T25567	T25565	conj	GAPDH,STAT6
R19088	T25568	T25568	ROOT	served,served
R19089	T25569	T25568	prep	as,served
R19090	T25570	T25571	amod	internal,control
R19091	T25571	T25569	pobj	control,as
R19092	T25572	T25568	punct	.,served
R19093	T25573	T25582	punct	(,shown
R19094	T25574	T25577	nmod	D,GATA3
R19095	T25575	T25574	punct	),D
R19096	T25576	T25577	compound	Intracellular,GATA3
R19097	T25577	T25582	nsubjpass	GATA3,shown
R19098	T25578	T25577	cc	and,GATA3
R19099	T25579	T25577	conj	FOXP3,GATA3
R19100	T25580	T25582	nsubjpass	staining,shown
R19101	T25581	T25582	auxpass	are,shown
R19102	T25582	T25582	ROOT	shown,shown
R19103	T25583	T25600	prep	after,are
R19104	T25584	T25583	pobj	exposure,after
R19105	T25585	T25584	prep	of,exposure
R19106	T25586	T25588	compound	CD4,CD45RA
R19107	T25587	T25588	compound	+,CD45RA
R19108	T25588	T25585	pobj	CD45RA,of
R19109	T25589	T25600	advcl	+,are
R19110	T25590	T25591	compound	T,cells
R19111	T25591	T25589	dobj	cells,+
R19112	T25592	T25595	aux	to,described
R19113	T25593	T25592	pobj	IL-4,to
R19114	T25594	T25595	mark	as,described
R19115	T25595	T25600	advcl	described,are
R19116	T25596	T25595	prep	for,described
R19117	T25597	T25599	compound	panel,Data
R19118	T25598	T25599	compound	B.,Data
R19119	T25599	T25596	pobj	Data,for
R19120	T25600	T25582	ccomp	are,shown
R19121	T25601	T25600	acomp	representative,are
R19122	T25602	T25601	prep	of,representative
R19123	T25603	T25605	nummod	three,experiments
R19124	T25604	T25605	amod	independent,experiments
R19125	T25605	T25602	pobj	experiments,of
R19126	T25606	T25600	punct	.,are
R5439	T7091	T7093	nsubjpass	cells,activated
R5441	T7092	T7093	auxpass	were,activated
R5442	T7093	T7093	ROOT	activated,activated
R5628	T7325	T7326	punct	(,mAbs
R5630	T7326	T7324	appos	mAbs,antibodies
R5631	T7327	T7326	punct	),mAbs
R5633	T7328	T7324	punct	",",antibodies

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T6396	910-919	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6397	1068-1077	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6398	933-948	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T7638	0-4	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7639	46-50	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7640	171-175	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7641	361-365	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7642	391-395	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7643	584-588	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7644	656-660	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7645	774-778	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7646	817-821	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7647	1003-1007	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7648	1046-1050	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7649	1152-1156	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T25637	2723-2727	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T25638	2851-2855	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T25639	3216-3220	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T25640	3392-3396	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T25641	3670-3674	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7650	1294-1298	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7651	1534-1538	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7652	1558-1562	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7653	1878-1882	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7654	2152-2156	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7655	2282-2286	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7656	2395-2399	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7657	2488-2492	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7658	2675-2679	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T7659	1574-1584	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies
T7660	1776-1784	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibody

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T7661	86-91	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7662	250-255	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7663	277-282	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7664	1462-1467	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7665	1738-1743	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7666	1960-1965	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7667	2088-2093	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7668	2130-2135	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7669	2339-2344	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7670	2372-2377	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7671	2385-2390	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7672	2481-2486	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7673	2630-2635	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T7674	1166-1179	http://purl.obolibrary.org/obo/GO_0005622	denotes	intracellular
T7675	1574-1584	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T7676	1776-1784	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibody
T7677	1574-1584	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies
T7678	1776-1784	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibody
T25642	3096-3101	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T25643	3308-3313	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T25644	3661-3666	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T25645	3580-3593	http://purl.obolibrary.org/obo/GO_0005622	denotes	Intracellular

sentences

Id	Subject	Object	Predicate	Lexical cue
T6377	0-45	Sentence	denotes	IL-4 Inhibits TGF-β-Mediated iTreg Commitment
T6378	46-143	Sentence	denotes	IL-4 induces differentiation of naive T cells, upon antigen encounter, into the Th2 cell lineage.
T6379	144-256	Sentence	denotes	We therefore asked whether IL-4 is able to inhibit TGF-β induction of FOXP3 during the priming of naive T cells.
T6380	257-390	Sentence	denotes	Human CD4+CD45RA+ T cells were activated with plate-bound anti-CD3/CD28 in the presence of TGF-β and/or IL-4 and harvested after 5 d.
T6381	391-527	Sentence	denotes	IL-4 efficiently repressed the TGF-β–mediated induction of FOXP3 expression (Figure 5A) in a concentration-dependent manner (Figure 5B).
T6382	528-624	Sentence	denotes	Low levels of GATA3 were induced also in the absence of IL-4, as it was previously observed [3].
T6383	625-708	Sentence	denotes	However, at low concentration, IL-4 was able to marginally induce FOXP3 expression.
T6384	709-812	Sentence	denotes	Of note, GATA3 was also induced in the presence of TGF-β at high IL-4 concentration (Figure 5A and 5B).
T6385	813-1129	Sentence	denotes	The IL-4–mediated prevention of FOXP3 expression was not caused by interferences of the receptor signaling, because the phosphorylation of SMAD2 or STAT6 was not affected by the addition of IL-4 and/or TGF-β, which demonstrates that IL-4 as well as TGF-β signaling were functional under these conditions (Figure 5C).
T6386	1130-1267	Sentence	denotes	Increasing amounts of IL-4 increase intracellular GATA3, whereas FOXP3 decreased, which is consistent with the mRNA analysis (Figure 5D).
T6387	1268-1377	Sentence	denotes	Furthermore, injection of IL-4 into wild-type B6 mice decreased the inducible or natural Treg number in vivo.
T6388	1378-1494	Sentence	denotes	A distinction of the Treg subsets is not possible, because recently activated iTreg cells also express surface CD25.
T6389	1495-1681	Sentence	denotes	We used complexes of recombinant mouse IL-4 (rmIL-4) plus anti-IL-4 monoclonal antibodies (mAbs), which have been shown to dramatically increase the potency of the cytokine in vivo [19].
T6390	1682-1837	Sentence	denotes	In these mice, the percentage of CD4+CD25+ and FOXP3+ T cells dramatically decreased when the antibody-cytokine immune complexes were injected (Figure S2).
T6391	1838-2136	Sentence	denotes	Upon administration of rmIL-4 plus anti-IL-4 mAb complexes, the total number of CD4+CD25+ T cell, as well as the Foxp3+ T cells diminished by half (Figure S2G and S2H), confirming that the lower percentage was not due to an increase in the CD4+CD25– cells, but a real decrease of CD4+CD25+ T cells.
T6392	2137-2257	Sentence	denotes	In conclusion, IL-4 negatively regulates the natural or inducible Treg cell turnover not only in vitro but also in vivo.
T6393	2258-2455	Sentence	denotes	To study the effects of IL-4 on already-existing human natural or inducible Treg cells, we exposed sorted CD25+ T cells (nTreg cells) to IL-4 and analyzed FOXP3 expression and suppressive capacity.
T6394	2456-2600	Sentence	denotes	In already-existing Treg cells, IL-4 failed to inhibit FOXP3 expression (Figure S3A), and the suppressive capacity was not altered (Figure S3C).
T6395	2601-2702	Sentence	denotes	Similarly pre-existing iTreg cells did not decrease FOXP3 expression upon IL-4 exposure (Figure S3B).
T25148	2713-2746	Sentence	denotes	Effect of IL-4 on FOXP3 Induction
T25149	2747-2935	Sentence	denotes	(A) A statistical analysis was performed with six donors on day 5 (TGF-β (10 ng/ml) and with or without IL-4 (100 ng/ml)); Shown is the mean, and error bars indicated the SD of six donors.
T25150	2936-2994	Sentence	denotes	Statistical analysis was performed using the Dunnett test.
T25151	2995-3079	Sentence	denotes	Statistical significance is indicated by asterisks (p ≤ 0.05, *p ≤ 0.01, Dunnett).
T25152	3080-3235	Sentence	denotes	(B) CD4+CD45RA+ cells were activated in the presence of a constant concentration of TGF-β (5 ng/ml) with an increasing concentration of IL-4, as indicated.
T25153	3236-3291	Sentence	denotes	Cells were harvested for mRNA quantification after 5 d.
T25154	3292-3422	Sentence	denotes	(C) CD4+CD45RA+ cells were stimulated in vitro with plate-bound anti-CD3/CD28, TGF-β (10ng/ml), and IL-4 (100 ng/ml) as indicated.
T25155	3423-3525	Sentence	denotes	After 1 h, cell lysates were prepared and analyzed by Western blot for phosphorylated SMAD2 and STAT6.
T25156	3526-3575	Sentence	denotes	Total STAT6 and GAPDH served as internal control.
T25157	3576-3758	Sentence	denotes	(D) Intracellular GATA3 and FOXP3 staining are shown after exposure of CD4+CD45RA+ T cells to IL-4 as described for panel B. Data are representative of three independent experiments.
T104	0-45	Sentence	denotes	IL-4 Inhibits TGF-β-Mediated iTreg Commitment
T105	46-143	Sentence	denotes	IL-4 induces differentiation of naive T cells, upon antigen encounter, into the Th2 cell lineage.
T106	144-256	Sentence	denotes	We therefore asked whether IL-4 is able to inhibit TGF-β induction of FOXP3 during the priming of naive T cells.
T107	257-390	Sentence	denotes	Human CD4+CD45RA+ T cells were activated with plate-bound anti-CD3/CD28 in the presence of TGF-β and/or IL-4 and harvested after 5 d.
T108	391-527	Sentence	denotes	IL-4 efficiently repressed the TGF-β–mediated induction of FOXP3 expression (Figure 5A) in a concentration-dependent manner (Figure 5B).
T109	528-624	Sentence	denotes	Low levels of GATA3 were induced also in the absence of IL-4, as it was previously observed [3].
T110	625-708	Sentence	denotes	However, at low concentration, IL-4 was able to marginally induce FOXP3 expression.
T111	709-812	Sentence	denotes	Of note, GATA3 was also induced in the presence of TGF-β at high IL-4 concentration (Figure 5A and 5B).
T112	813-1129	Sentence	denotes	The IL-4–mediated prevention of FOXP3 expression was not caused by interferences of the receptor signaling, because the phosphorylation of SMAD2 or STAT6 was not affected by the addition of IL-4 and/or TGF-β, which demonstrates that IL-4 as well as TGF-β signaling were functional under these conditions (Figure 5C).
T113	1130-1267	Sentence	denotes	Increasing amounts of IL-4 increase intracellular GATA3, whereas FOXP3 decreased, which is consistent with the mRNA analysis (Figure 5D).
T114	1268-1377	Sentence	denotes	Furthermore, injection of IL-4 into wild-type B6 mice decreased the inducible or natural Treg number in vivo.
T115	1378-1494	Sentence	denotes	A distinction of the Treg subsets is not possible, because recently activated iTreg cells also express surface CD25.
T116	1495-1681	Sentence	denotes	We used complexes of recombinant mouse IL-4 (rmIL-4) plus anti-IL-4 monoclonal antibodies (mAbs), which have been shown to dramatically increase the potency of the cytokine in vivo [19].
T117	1682-1837	Sentence	denotes	In these mice, the percentage of CD4+CD25+ and FOXP3+ T cells dramatically decreased when the antibody-cytokine immune complexes were injected (Figure S2).
T118	1838-2136	Sentence	denotes	Upon administration of rmIL-4 plus anti-IL-4 mAb complexes, the total number of CD4+CD25+ T cell, as well as the Foxp3+ T cells diminished by half (Figure S2G and S2H), confirming that the lower percentage was not due to an increase in the CD4+CD25– cells, but a real decrease of CD4+CD25+ T cells.
T119	2137-2257	Sentence	denotes	In conclusion, IL-4 negatively regulates the natural or inducible Treg cell turnover not only in vitro but also in vivo.
T120	2258-2455	Sentence	denotes	To study the effects of IL-4 on already-existing human natural or inducible Treg cells, we exposed sorted CD25+ T cells (nTreg cells) to IL-4 and analyzed FOXP3 expression and suppressive capacity.
T121	2456-2600	Sentence	denotes	In already-existing Treg cells, IL-4 failed to inhibit FOXP3 expression (Figure S3A), and the suppressive capacity was not altered (Figure S3C).
T122	2601-2702	Sentence	denotes	Similarly pre-existing iTreg cells did not decrease FOXP3 expression upon IL-4 exposure (Figure S3B).
T123	2703-2746	Sentence	denotes	Figure 5 Effect of IL-4 on FOXP3 Induction
T124	2747-2935	Sentence	denotes	(A) A statistical analysis was performed with six donors on day 5 (TGF-β (10 ng/ml) and with or without IL-4 (100 ng/ml)); Shown is the mean, and error bars indicated the SD of six donors.
T125	2936-2994	Sentence	denotes	Statistical analysis was performed using the Dunnett test.
T126	2995-3079	Sentence	denotes	Statistical significance is indicated by asterisks (p ≤ 0.05, *p ≤ 0.01, Dunnett).
T127	3080-3235	Sentence	denotes	(B) CD4+CD45RA+ cells were activated in the presence of a constant concentration of TGF-β (5 ng/ml) with an increasing concentration of IL-4, as indicated.
T128	3236-3291	Sentence	denotes	Cells were harvested for mRNA quantification after 5 d.
T129	3292-3422	Sentence	denotes	(C) CD4+CD45RA+ cells were stimulated in vitro with plate-bound anti-CD3/CD28, TGF-β (10ng/ml), and IL-4 (100 ng/ml) as indicated.
T130	3423-3525	Sentence	denotes	After 1 h, cell lysates were prepared and analyzed by Western blot for phosphorylated SMAD2 and STAT6.
T131	3526-3575	Sentence	denotes	Total STAT6 and GAPDH served as internal control.
T132	3576-3700	Sentence	denotes	(D) Intracellular GATA3 and FOXP3 staining are shown after exposure of CD4+CD45RA+ T cells to IL-4 as described for panel B.
T133	3701-3758	Sentence	denotes	Data are representative of three independent experiments.

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T7945	0-4	Protein	denotes	IL-4
T7946	14-19	Protein	denotes	TGF-β
T7947	46-50	Protein	denotes	IL-4
T7948	171-175	Protein	denotes	IL-4
T7949	187-194	Negative_regulation	denotes	inhibit		true
T7950	195-200	Protein	denotes	TGF-β
T7951	201-210	Positive_regulation	denotes	induction
T7952	214-219	Protein	denotes	FOXP3
T7953	263-266	Protein	denotes	CD4
T7954	267-273	Protein	denotes	CD45RA
T7955	320-323	Protein	denotes	CD3
T7956	324-328	Protein	denotes	CD28
T7957	348-353	Protein	denotes	TGF-β
T7958	361-365	Protein	denotes	IL-4
T7959	391-395	Protein	denotes	IL-4
T7960	408-417	Negative_regulation	denotes	repressed
T7961	422-427	Protein	denotes	TGF-β
T7962	437-446	Positive_regulation	denotes	induction
T7963	450-455	Protein	denotes	FOXP3
T7964	456-466	Gene_expression	denotes	expression
T7965	542-547	Protein	denotes	GATA3
T7966	553-560	Negative_regulation	denotes	induced	true
T7967	573-580	Negative_regulation	denotes	absence
T7968	584-588	Protein	denotes	IL-4
T7969	656-660	Protein	denotes	IL-4
T7970	684-690	Positive_regulation	denotes	induce
T7971	691-696	Protein	denotes	FOXP3
T7972	697-707	Gene_expression	denotes	expression
T7973	718-723	Protein	denotes	GATA3
T7974	733-740	Positive_regulation	denotes	induced
T7975	733-740	Positive_regulation	denotes	induced
T7976	760-765	Protein	denotes	TGF-β
T7977	774-778	Protein	denotes	IL-4
T7978	817-821	Protein	denotes	IL-4
T7979	831-841	Negative_regulation	denotes	prevention
T7980	845-850	Protein	denotes	FOXP3
T7981	851-861	Gene_expression	denotes	expression
T7982	870-876	Positive_regulation	denotes	caused	true
T7983	933-948	Phosphorylation	denotes	phosphorylation
T7984	933-948	Phosphorylation	denotes	phosphorylation
T7985	952-957	Protein	denotes	SMAD2
T7986	961-966	Protein	denotes	STAT6
T7987	975-983	Regulation	denotes	affected	true
T7988	975-983	Regulation	denotes	affected	true
T7989	975-983	Regulation	denotes	affected	true
T7990	975-983	Regulation	denotes	affected	true
T7991	1003-1007	Protein	denotes	IL-4
T7992	1015-1020	Protein	denotes	TGF-β
T7993	1046-1050	Protein	denotes	IL-4
T7994	1062-1067	Protein	denotes	TGF-β
T7995	1130-1148	Positive_regulation	denotes	Increasing amounts
T7996	1152-1156	Protein	denotes	IL-4
T7997	1157-1165	Positive_regulation	denotes	increase
T7998	1180-1185	Protein	denotes	GATA3
T7999	1195-1200	Protein	denotes	FOXP3
T8000	1201-1210	Negative_regulation	denotes	decreased
T8001	1294-1298	Protein	denotes	IL-4
T8002	1473-1480	Gene_expression	denotes	express
T8003	1489-1493	Protein	denotes	CD25
T8004	1534-1538	Protein	denotes	IL-4
T8005	1540-1546	Protein	denotes	rmIL-4
T8006	1558-1562	Protein	denotes	IL-4
T8007	1715-1718	Protein	denotes	CD4
T8008	1719-1723	Protein	denotes	CD25
T8009	1729-1734	Protein	denotes	FOXP3
T8010	1861-1867	Protein	denotes	rmIL-4
T8011	1878-1882	Protein	denotes	IL-4
T8012	1918-1921	Protein	denotes	CD4
T8013	1922-1926	Protein	denotes	CD25
T8014	1951-1956	Protein	denotes	Foxp3
T8015	2078-2081	Protein	denotes	CD4
T8016	2082-2086	Protein	denotes	CD25
T8017	2118-2121	Protein	denotes	CD4
T8018	2122-2126	Protein	denotes	CD25
T8019	2152-2156	Protein	denotes	IL-4
T8020	2282-2286	Protein	denotes	IL-4
T8021	2364-2368	Protein	denotes	CD25
T8022	2395-2399	Protein	denotes	IL-4
T8023	2413-2418	Protein	denotes	FOXP3
T8024	2419-2429	Gene_expression	denotes	expression
T8025	2434-2454	Negative_regulation	denotes	suppressive capacity		true
T8026	2488-2492	Protein	denotes	IL-4
T8027	2503-2510	Negative_regulation	denotes	inhibit	true
T8028	2511-2516	Protein	denotes	FOXP3
T8029	2517-2527	Gene_expression	denotes	expression
T8030	2579-2586	Regulation	denotes	altered	true
T8031	2644-2652	Negative_regulation	denotes	decrease	true
T8032	2653-2658	Protein	denotes	FOXP3
T8033	2659-2669	Gene_expression	denotes	expression
T8034	2675-2679	Protein	denotes	IL-4
T25761	2713-2719	Regulation	denotes	Effect
T25762	2723-2727	Protein	denotes	IL-4
T25763	2731-2736	Protein	denotes	FOXP3
T25764	2737-2746	Positive_regulation	denotes	Induction
T25765	2814-2819	Protein	denotes	TGF-β
T25766	2851-2855	Protein	denotes	IL-4
T25767	3084-3087	Protein	denotes	CD4
T25768	3088-3094	Protein	denotes	CD45RA
T25769	3164-3169	Protein	denotes	TGF-β
T25770	3188-3198	Positive_regulation	denotes	increasing
T25771	3216-3220	Protein	denotes	IL-4
T25772	3296-3299	Protein	denotes	CD4
T25773	3300-3306	Protein	denotes	CD45RA
T25774	3361-3364	Protein	denotes	CD3
T25775	3365-3369	Protein	denotes	CD28
T25776	3371-3376	Protein	denotes	TGF-β
T25777	3392-3396	Protein	denotes	IL-4
T25778	3494-3508	Phosphorylation	denotes	phosphorylated		true
T25779	3494-3508	Phosphorylation	denotes	phosphorylated		true
T25780	3509-3514	Protein	denotes	SMAD2
T25781	3519-3524	Protein	denotes	STAT6
T25782	3532-3537	Protein	denotes	STAT6
T25783	3542-3547	Protein	denotes	GAPDH
T25784	3594-3599	Protein	denotes	GATA3
T25785	3604-3609	Protein	denotes	FOXP3
T25786	3610-3618	Gene_expression	denotes	staining
T25787	3610-3618	Gene_expression	denotes	staining
T25788	3647-3650	Protein	denotes	CD4
T25789	3651-3657	Protein	denotes	CD45RA
T25790	3670-3674	Protein	denotes	IL-4
R6096	T7948	T7949	causeOf	IL-4,inhibit
R6098	T7950	T7951	causeOf	TGF-β,induction
R6099	T7951	T7949	themeOf	induction,inhibit
R6100	T7952	T7951	themeOf	FOXP3,induction
R6104	T7959	T7960	causeOf	IL-4,repressed
R6105	T7961	T7962	causeOf	TGF-β,induction
R6106	T7962	T7960	themeOf	induction,repressed
R6108	T7963	T7964	themeOf	FOXP3,expression
R6109	T7964	T7962	themeOf	expression,induction
R6110	T7965	T7966	themeOf	GATA3,induced
R6112	T7967	T7966	causeOf	absence,induced
R6113	T7968	T7967	themeOf	IL-4,absence
R6114	T7969	T7970	causeOf	IL-4,induce
R6116	T8032	T8033	themeOf	FOXP3,expression
R6117	T7971	T7972	themeOf	FOXP3,expression
R6118	T7972	T7970	themeOf	expression,induce
R6119	T7973	T7974	themeOf	GATA3,induced
R6120	T7973	T7975	themeOf	GATA3,induced
R6121	T7976	T7974	causeOf	TGF-β,induced
R6122	T7977	T7975	causeOf	IL-4,induced
R6123	T7978	T7979	causeOf	IL-4,prevention
R6124	T7979	T7982	themeOf	prevention,caused
R6125	T7980	T7981	themeOf	FOXP3,expression
R6126	T7981	T7979	themeOf	expression,prevention
R6127	T7983	T7987	themeOf	phosphorylation,affected
R6128	T7983	T7988	themeOf	phosphorylation,affected
R6129	T7984	T7989	themeOf	phosphorylation,affected
R6130	T7984	T7990	themeOf	phosphorylation,affected
R6131	T7985	T7983	themeOf	SMAD2,phosphorylation
R6132	T7986	T7984	themeOf	STAT6,phosphorylation
R6133	T8033	T8031	themeOf	expression,decrease
R6134	T7991	T7987	causeOf	IL-4,affected
R6135	T7991	T7989	causeOf	IL-4,affected
R6136	T7992	T7988	causeOf	TGF-β,affected
R6137	T7992	T7990	causeOf	TGF-β,affected
R6138	T8034	T8031	causeOf	IL-4,decrease
R6139	T7995	T7997	causeOf	Increasing amounts,increase
R6140	T7995	T8000	causeOf	Increasing amounts,decreased
R6141	T7996	T7995	themeOf	IL-4,Increasing amounts
R6143	T7998	T7997	themeOf	GATA3,increase
R6144	T7999	T8000	themeOf	FOXP3,decreased
R6145	T8003	T8002	themeOf	CD25,express
R6146	T8005	T8004	equivalentTo	rmIL-4,IL-4
R6151	T8022	T8025	causeOf	IL-4,suppressive capacity
R6152	T8023	T8024	themeOf	FOXP3,expression
R6153	T8024	T8025	themeOf	expression,suppressive capacity
R6154	T8026	T8027	causeOf	IL-4,inhibit
R6156	T8027	T8030	themeOf	inhibit,altered
R6157	T8028	T8029	themeOf	FOXP3,expression
R6158	T8029	T8027	themeOf	expression,inhibit
R19167	T25762	T25761	causeOf	IL-4,Effect
R19168	T25763	T25764	themeOf	FOXP3,Induction
R19169	T25764	T25761	themeOf	Induction,Effect
R19170	T25771	T25770	themeOf	IL-4,increasing
R19171	T25780	T25779	themeOf	SMAD2,phosphorylated
R19172	T25781	T25778	themeOf	STAT6,phosphorylated
R19173	T25784	T25786	themeOf	GATA3,staining
R19174	T25785	T25787	themeOf	FOXP3,staining

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T25646	2723-2727	Protein	denotes	IL-4
T25647	2731-2736	Protein	denotes	FOXP3
T25648	2737-2746	Positive_regulation	denotes	Induction
T25649	2713-2719	Regulation	denotes	Effect
T25650	2851-2855	Protein	denotes	IL-4
T25651	3084-3087	Protein	denotes	CD4
T25652	3088-3094	Protein	denotes	CD45RA
T25653	3164-3169	Protein	denotes	TGF-β
T25654	3216-3220	Protein	denotes	IL-4
T25655	3188-3198	Positive_regulation	denotes	increasing
T25656	3296-3299	Protein	denotes	CD4
T25657	3300-3306	Protein	denotes	CD45RA
T25658	3361-3364	Protein	denotes	CD3
T25659	3365-3369	Protein	denotes	CD28
T25660	3371-3376	Protein	denotes	TGF-β
T25661	3392-3396	Protein	denotes	IL-4
T25662	3509-3514	Protein	denotes	SMAD2
T25663	3519-3524	Protein	denotes	STAT6
T25664	3494-3508	Phosphorylation	denotes	phosphorylated
T25665	3494-3508	Phosphorylation	denotes	phosphorylated
T25666	3532-3537	Protein	denotes	STAT6
T25667	3542-3547	Protein	denotes	GAPDH
T25668	3594-3599	Protein	denotes	GATA3
T25669	3604-3609	Protein	denotes	FOXP3
T25670	3647-3650	Protein	denotes	CD4
T25671	3651-3657	Protein	denotes	CD45RA
T25672	3670-3674	Protein	denotes	IL-4
T25673	3610-3618	Gene_expression	denotes	staining
T25674	3610-3618	Gene_expression	denotes	staining
R19135	T25646	T25649	causeOf	IL-4,Effect
R19136	T25647	T25648	themeOf	FOXP3,Induction
R19137	T25648	T25649	themeOf	Induction,Effect
R19138	T25654	T25655	themeOf	IL-4,increasing
R19139	T25662	T25664	themeOf	SMAD2,phosphorylated
R19140	T25663	T25665	themeOf	STAT6,phosphorylated
R19141	T25668	T25673	themeOf	GATA3,staining
R19142	T25669	T25674	themeOf	FOXP3,staining

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T6399	187-194	Negative_regulation	denotes	inhibit		true
T6400	733-740	Positive_regulation	denotes	induced
T6401	733-740	Positive_regulation	denotes	induced
T6402	831-841	Negative_regulation	denotes	prevention
T6403	851-861	Gene_expression	denotes	expression
T6404	870-876	Positive_regulation	denotes	caused	true
T6405	933-948	Phosphorylation	denotes	phosphorylation
T6406	933-948	Phosphorylation	denotes	phosphorylation
T6407	975-983	Regulation	denotes	affected	true
T6408	975-983	Regulation	denotes	affected	true
T6409	975-983	Regulation	denotes	affected	true
T6410	201-210	Positive_regulation	denotes	induction
T6411	975-983	Regulation	denotes	affected	true
T6412	1130-1148	Positive_regulation	denotes	Increasing amounts
T6413	1157-1165	Positive_regulation	denotes	increase
T6414	1201-1210	Negative_regulation	denotes	decreased
T6415	1473-1480	Gene_expression	denotes	express
T6416	2419-2429	Gene_expression	denotes	expression
T6417	2434-2454	Negative_regulation	denotes	suppressive capacity		true
T6418	2503-2510	Negative_regulation	denotes	inhibit	true
T6419	2517-2527	Gene_expression	denotes	expression
T6420	2579-2586	Regulation	denotes	altered	true
T6421	408-417	Negative_regulation	denotes	repressed
T6422	2644-2652	Negative_regulation	denotes	decrease	true
T6423	2659-2669	Gene_expression	denotes	expression
T6424	437-446	Positive_regulation	denotes	induction
T6425	456-466	Gene_expression	denotes	expression
T6426	553-560	Negative_regulation	denotes	induced	true
T6427	573-580	Negative_regulation	denotes	absence
T6428	684-690	Positive_regulation	denotes	induce
T6429	697-707	Gene_expression	denotes	expression
T6430	0-4	Protein	denotes	IL-4
T6431	324-328	Protein	denotes	CD28
T6432	348-353	Protein	denotes	TGF-β
T6433	361-365	Protein	denotes	IL-4
T6434	391-395	Protein	denotes	IL-4
T6435	450-455	Protein	denotes	FOXP3
T6436	542-547	Protein	denotes	GATA3
T6437	584-588	Protein	denotes	IL-4
T6438	656-660	Protein	denotes	IL-4
T6439	691-696	Protein	denotes	FOXP3
T6440	14-19	Protein	denotes	TGF-β
T6441	718-723	Protein	denotes	GATA3
T6442	760-765	Protein	denotes	TGF-β
T6443	774-778	Protein	denotes	IL-4
T6444	817-821	Protein	denotes	IL-4
T6445	845-850	Protein	denotes	FOXP3
T6446	952-957	Protein	denotes	SMAD2
T6447	961-966	Protein	denotes	STAT6
T6448	1003-1007	Protein	denotes	IL-4
T6449	1015-1020	Protein	denotes	TGF-β
T6450	1046-1050	Protein	denotes	IL-4
T6451	46-50	Protein	denotes	IL-4
T6452	1062-1067	Protein	denotes	TGF-β
T6453	1152-1156	Protein	denotes	IL-4
T6454	1180-1185	Protein	denotes	GATA3
T6455	1195-1200	Protein	denotes	FOXP3
T6456	1294-1298	Protein	denotes	IL-4
T6457	1489-1493	Protein	denotes	CD25
T6458	1534-1538	Protein	denotes	IL-4
T6459	1540-1546	Protein	denotes	rmIL-4
T6460	1558-1562	Protein	denotes	IL-4
T6461	1715-1718	Protein	denotes	CD4
T6462	171-175	Protein	denotes	IL-4
T6463	1719-1723	Protein	denotes	CD25
T6464	1729-1734	Protein	denotes	FOXP3
T6465	1861-1867	Protein	denotes	rmIL-4
T6466	1878-1882	Protein	denotes	IL-4
T6467	1918-1921	Protein	denotes	CD4
T6468	1922-1926	Protein	denotes	CD25
T6469	1951-1956	Protein	denotes	Foxp3
T6470	2078-2081	Protein	denotes	CD4
T6471	2082-2086	Protein	denotes	CD25
T6472	2118-2121	Protein	denotes	CD4
T6473	195-200	Protein	denotes	TGF-β
T6474	2122-2126	Protein	denotes	CD25
T6475	2152-2156	Protein	denotes	IL-4
T6476	2282-2286	Protein	denotes	IL-4
T6477	2364-2368	Protein	denotes	CD25
T6478	2395-2399	Protein	denotes	IL-4
T6479	2413-2418	Protein	denotes	FOXP3
T6480	2488-2492	Protein	denotes	IL-4
T6481	2511-2516	Protein	denotes	FOXP3
T6482	2653-2658	Protein	denotes	FOXP3
T6483	2675-2679	Protein	denotes	IL-4
T6484	214-219	Protein	denotes	FOXP3
T6485	263-266	Protein	denotes	CD4
T6486	267-273	Protein	denotes	CD45RA
T6487	320-323	Protein	denotes	CD3
T25140	3542-3547	Protein	denotes	GAPDH
T25141	3594-3599	Protein	denotes	GATA3
T25142	3604-3609	Protein	denotes	FOXP3
T25143	3610-3618	Gene_expression	denotes	staining
T25144	3610-3618	Gene_expression	denotes	staining
T25145	3647-3650	Protein	denotes	CD4
T25146	3651-3657	Protein	denotes	CD45RA
T25147	3670-3674	Protein	denotes	IL-4
T25118	2713-2719	Regulation	denotes	Effect
T25119	2723-2727	Protein	denotes	IL-4
T25120	2731-2736	Protein	denotes	FOXP3
T25121	2737-2746	Positive_regulation	denotes	Induction
T25122	2814-2819	Protein	denotes	TGF-β
T25123	2851-2855	Protein	denotes	IL-4
T25124	3084-3087	Protein	denotes	CD4
T25125	3088-3094	Protein	denotes	CD45RA
T25126	3164-3169	Protein	denotes	TGF-β
T25127	3188-3198	Positive_regulation	denotes	increasing
T25128	3216-3220	Protein	denotes	IL-4
T25129	3296-3299	Protein	denotes	CD4
T25130	3300-3306	Protein	denotes	CD45RA
T25131	3361-3364	Protein	denotes	CD3
T25132	3365-3369	Protein	denotes	CD28
T25133	3371-3376	Protein	denotes	TGF-β
T25134	3392-3396	Protein	denotes	IL-4
T25135	3494-3508	Phosphorylation	denotes	phosphorylated		true
T25136	3494-3508	Phosphorylation	denotes	phosphorylated		true
T25137	3509-3514	Protein	denotes	SMAD2
T25138	3519-3524	Protein	denotes	STAT6
T25139	3532-3537	Protein	denotes	STAT6
T6488	422-427	Protein	denotes	TGF-β
R4871	T6402	T6404	themeOf	prevention,caused
R4872	T6403	T6402	themeOf	expression,prevention
R4873	T6405	T6407	themeOf	phosphorylation,affected
R4874	T6405	T6408	themeOf	phosphorylation,affected
R4875	T6406	T6409	themeOf	phosphorylation,affected
R4876	T6406	T6411	themeOf	phosphorylation,affected
R4877	T6410	T6399	themeOf	induction,inhibit
R4878	T6412	T6413	causeOf	Increasing amounts,increase
R4879	T6412	T6414	causeOf	Increasing amounts,decreased
R4880	T6416	T6417	themeOf	expression,suppressive capacity
R4881	T6418	T6420	themeOf	inhibit,altered
R4882	T6419	T6418	themeOf	expression,inhibit
R4883	T6488	T6424	causeOf	TGF-β,induction
R4894	T6423	T6422	themeOf	expression,decrease
R4897	T6424	T6421	themeOf	induction,repressed
R4898	T6425	T6424	themeOf	expression,induction
R4899	T6427	T6426	causeOf	absence,induced
R4901	T6429	T6428	themeOf	expression,induce
R4904	T6434	T6421	causeOf	IL-4,repressed
R4905	T6435	T6425	themeOf	FOXP3,expression
R4906	T6436	T6426	themeOf	GATA3,induced
R4908	T6437	T6427	themeOf	IL-4,absence
R4910	T6438	T6428	causeOf	IL-4,induce
R4911	T6439	T6429	themeOf	FOXP3,expression
R4912	T6441	T6400	themeOf	GATA3,induced
R4913	T6441	T6401	themeOf	GATA3,induced
R4914	T6442	T6400	causeOf	TGF-β,induced
R4915	T6443	T6401	causeOf	IL-4,induced
R4916	T6444	T6402	causeOf	IL-4,prevention
R4917	T6445	T6403	themeOf	FOXP3,expression
R4918	T6446	T6405	themeOf	SMAD2,phosphorylation
R4920	T6447	T6406	themeOf	STAT6,phosphorylation
R4922	T6448	T6407	causeOf	IL-4,affected
R4923	T6448	T6409	causeOf	IL-4,affected
R4924	T6449	T6408	causeOf	TGF-β,affected
R4925	T6449	T6411	causeOf	TGF-β,affected
R4928	T6453	T6412	themeOf	IL-4,Increasing amounts
R4930	T6454	T6413	themeOf	GATA3,increase
R4931	T6455	T6414	themeOf	FOXP3,decreased
R4932	T6457	T6415	themeOf	CD25,express
R4934	T6459	T6458	equivalentTo	rmIL-4,IL-4
R4936	T6462	T6399	causeOf	IL-4,inhibit
R4941	T6473	T6410	causeOf	TGF-β,induction
R4945	T6478	T6417	causeOf	IL-4,suppressive capacity
R4946	T6479	T6416	themeOf	FOXP3,expression
R4947	T6480	T6418	causeOf	IL-4,inhibit
R4948	T6481	T6419	themeOf	FOXP3,expression
R4950	T6482	T6423	themeOf	FOXP3,expression
R4951	T6483	T6422	causeOf	IL-4,decrease
R4952	T6484	T6410	themeOf	FOXP3,induction
R18703	T25121	T25118	themeOf	Induction,Effect
R18704	T25128	T25127	themeOf	IL-4,increasing
R18705	T25137	T25136	themeOf	SMAD2,phosphorylated
R18706	T25138	T25135	themeOf	STAT6,phosphorylated
R18707	T25141	T25143	themeOf	GATA3,staining
R18708	T25142	T25144	themeOf	FOXP3,staining
R18701	T25119	T25118	causeOf	IL-4,Effect
R18702	T25120	T25121	themeOf	FOXP3,Induction

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T6969	320-323	P04234	denotes	CD3
T6970	320-323	P20963	denotes	CD3
T6971	320-323	P07766	denotes	CD3
T6972	320-323	P09693	denotes	CD3
T6973	324-328	P10747	denotes	CD28
T6974	348-353	P01137	denotes	TGF-β
T6975	361-365	P05112	denotes	IL-4
T6976	391-395	P05112	denotes	IL-4
T6977	422-427	P01137	denotes	TGF-β
T6978	450-455	Q9BZS1	denotes	FOXP3
T6979	542-547	P23771	denotes	GATA3
T6980	584-588	P05112	denotes	IL-4
T6981	656-660	P05112	denotes	IL-4
T6982	665-669	P00519	denotes	able
T6983	691-696	Q9BZS1	denotes	FOXP3
T6984	718-723	P23771	denotes	GATA3
T6985	760-765	P01137	denotes	TGF-β
T6986	774-778	P05112	denotes	IL-4
T6987	817-821	P05112	denotes	IL-4
T6988	845-850	Q9BZS1	denotes	FOXP3
T6989	952-957	Q15796	denotes	SMAD2
T6990	961-966	P42226	denotes	STAT6
T6991	1003-1007	P05112	denotes	IL-4
T6992	1015-1020	P01137	denotes	TGF-β
T6993	1046-1050	P05112	denotes	IL-4
T6994	1062-1067	P01137	denotes	TGF-β
T6995	1152-1156	P05112	denotes	IL-4
T6996	1180-1185	P23771	denotes	GATA3
T6997	1195-1200	Q9BZS1	denotes	FOXP3
T6998	1294-1298	P05112	denotes	IL-4
T6999	1489-1493	P01589	denotes	CD25
T7000	1534-1538	P05112	denotes	IL-4
T7001	1558-1562	P05112	denotes	IL-4
T7002	1715-1718	P01730	denotes	CD4
T7003	1719-1723	P01589	denotes	CD25
T7004	1729-1734	Q9BZS1	denotes	FOXP3
T7005	1878-1882	P05112	denotes	IL-4
T7006	1918-1921	P01730	denotes	CD4
T7007	1922-1926	P01589	denotes	CD25
T7008	1951-1956	Q9BZS1	denotes	Foxp3
T7009	2078-2081	P01730	denotes	CD4
T7010	2082-2086	P01589	denotes	CD25
T7011	2118-2121	P01730	denotes	CD4
T7012	2122-2126	P01589	denotes	CD25
T7013	2152-2156	P05112	denotes	IL-4
T7014	2282-2286	P05112	denotes	IL-4
T7015	2364-2368	P01589	denotes	CD25
T7016	2395-2399	P05112	denotes	IL-4
T7017	2413-2418	Q9BZS1	denotes	FOXP3
T7018	2488-2492	P05112	denotes	IL-4
T7019	2511-2516	Q9BZS1	denotes	FOXP3
T7020	2653-2658	Q9BZS1	denotes	FOXP3
T7021	2675-2679	P05112	denotes	IL-4
T25354	2723-2727	P05112	denotes	IL-4
T25355	2731-2736	Q9BZS1	denotes	FOXP3
T25356	2814-2819	P01137	denotes	TGF-β
T25357	2851-2855	P05112	denotes	IL-4
T25358	3084-3087	P01730	denotes	CD4
T25359	3088-3094	P08575	denotes	CD45RA
T25360	3164-3169	P01137	denotes	TGF-β
T25361	3216-3220	P05112	denotes	IL-4
T25362	3296-3299	P01730	denotes	CD4
T25363	3300-3306	P08575	denotes	CD45RA
T25364	3361-3364	P20963	denotes	CD3
T25365	3361-3364	P07766	denotes	CD3
T25366	3361-3364	P04234	denotes	CD3
T25367	3361-3364	P09693	denotes	CD3
T25368	3365-3369	P10747	denotes	CD28
T25369	3371-3376	P01137	denotes	TGF-β
T25370	3392-3396	P05112	denotes	IL-4
T25371	3509-3514	Q15796	denotes	SMAD2
T25372	3519-3524	P42226	denotes	STAT6
T25373	3532-3537	P42226	denotes	STAT6
T25374	3542-3547	P04406	denotes	GAPDH
T25375	3594-3599	P23771	denotes	GATA3
T25376	3604-3609	Q9BZS1	denotes	FOXP3
T25377	3647-3650	P01730	denotes	CD4
T25378	3651-3657	P08575	denotes	CD45RA
T25379	3670-3674	P05112	denotes	IL-4
T6960	0-4	P05112	denotes	IL-4
T6961	14-19	P01137	denotes	TGF-β
T6962	46-50	P05112	denotes	IL-4
T6963	171-175	P05112	denotes	IL-4
T6964	179-183	P00519	denotes	able
T6965	195-200	P01137	denotes	TGF-β
T6966	214-219	Q9BZS1	denotes	FOXP3
T6967	263-266	P01730	denotes	CD4
T6968	267-273	P08575	denotes	CD45RA

test2

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T6292	0-4	Protein	denotes	IL-4		true
T6293	14-19	Protein	denotes	TGF-β
T6294	46-50	Protein	denotes	IL-4
T6295	171-175	Protein	denotes	IL-4
T6296	187-194	Negative_regulation	denotes	inhibit
T6297	195-200	Protein	denotes	TGF-β	true
T6298	201-210	Positive_regulation	denotes	induction
T6299	214-219	Protein	denotes	FOXP3
T6300	263-266	Protein	denotes	CD4
T6301	267-273	Protein	denotes	CD45RA
T6302	320-323	Protein	denotes	CD3
T6303	324-328	Protein	denotes	CD28
T6304	348-353	Protein	denotes	TGF-β
T6305	361-365	Protein	denotes	IL-4	true
T6306	391-395	Protein	denotes	IL-4
T6307	408-417	Negative_regulation	denotes	repressed
T6308	422-427	Protein	denotes	TGF-β	true
T6309	437-446	Positive_regulation	denotes	induction	true
T6310	450-455	Protein	denotes	FOXP3	true
T6311	456-466	Gene_expression	denotes	expression	true
T6312	542-547	Protein	denotes	GATA3
T6313	553-560	Positive_regulation	denotes	induced
T6314	573-580	Negative_regulation	denotes	absence
T6315	584-588	Protein	denotes	IL-4
T6316	656-660	Protein	denotes	IL-4
T6317	684-690	Positive_regulation	denotes	induce		true
T6318	691-696	Protein	denotes	FOXP3	true
T6319	697-707	Gene_expression	denotes	expression
T6320	718-723	Protein	denotes	GATA3	true
T6321	733-740	Positive_regulation	denotes	induced	true
T6322	760-765	Protein	denotes	TGF-β
T6323	769-773	Positive_regulation	denotes	high
T6324	774-778	Protein	denotes	IL-4
T6325	817-821	Protein	denotes	IL-4
T6326	831-841	Positive_regulation	denotes	prevention
T6327	845-850	Protein	denotes	FOXP3
T6328	851-861	Gene_expression	denotes	expression
T6329	870-876	Positive_regulation	denotes	caused
T6330	933-948	Phosphorylation	denotes	phosphorylation
T6331	952-957	Protein	denotes	SMAD2
T6332	961-966	Protein	denotes	STAT6
T6333	975-983	Regulation	denotes	affected
T6334	1003-1007	Protein	denotes	IL-4
T6335	1015-1020	Protein	denotes	TGF-β
T6336	1046-1050	Protein	denotes	IL-4
T6337	1062-1067	Protein	denotes	TGF-β
T6338	1152-1156	Protein	denotes	IL-4
T6339	1157-1165	Positive_regulation	denotes	increase
T6340	1180-1185	Protein	denotes	GATA3
T6341	1195-1200	Protein	denotes	FOXP3
T6342	1201-1210	Negative_regulation	denotes	decreased
T6343	1294-1298	Protein	denotes	IL-4
T6344	1473-1480	Gene_expression	denotes	express
T6345	1489-1493	Protein	denotes	CD25
T6346	1534-1538	Protein	denotes	IL-4
T6347	1540-1546	Protein	denotes	rmIL-4
T6348	1558-1562	Protein	denotes	IL-4
T6349	1715-1718	Protein	denotes	CD4
T6350	1719-1723	Protein	denotes	CD25
T6351	1729-1734	Protein	denotes	FOXP3
T6352	1861-1867	Protein	denotes	rmIL-4
T6353	1878-1882	Protein	denotes	IL-4
T6354	1918-1921	Protein	denotes	CD4
T6355	1922-1926	Protein	denotes	CD25
T6356	1951-1956	Protein	denotes	Foxp3
T6357	1966-1976	Negative_regulation	denotes	diminished
T6358	2078-2081	Protein	denotes	CD4
T6359	2082-2086	Protein	denotes	CD25
T6360	2118-2121	Protein	denotes	CD4
T6361	2122-2126	Protein	denotes	CD25
T6362	2152-2156	Protein	denotes	IL-4
T6363	2271-2278	Regulation	denotes	effects
T6364	2282-2286	Protein	denotes	IL-4
T6365	2364-2368	Protein	denotes	CD25
T6366	2395-2399	Protein	denotes	IL-4
T6367	2413-2418	Protein	denotes	FOXP3
T6368	2419-2429	Gene_expression	denotes	expression
T6369	2488-2492	Protein	denotes	IL-4
T6370	2503-2510	Negative_regulation	denotes	inhibit
T6371	2511-2516	Protein	denotes	FOXP3
T6372	2517-2527	Gene_expression	denotes	expression
T6373	2644-2652	Negative_regulation	denotes	decrease
T6374	2653-2658	Protein	denotes	FOXP3
T6375	2659-2669	Gene_expression	denotes	expression
T6376	2675-2679	Protein	denotes	IL-4
T25090	2713-2719	Regulation	denotes	Effect
T25091	2723-2727	Protein	denotes	IL-4
T25092	2731-2736	Protein	denotes	FOXP3
T25093	2737-2746	Positive_regulation	denotes	Induction		true
T25094	2814-2819	Protein	denotes	TGF-β		true
T25095	2851-2855	Protein	denotes	IL-4
T25096	3084-3087	Protein	denotes	CD4
T25097	3088-3094	Protein	denotes	CD45RA
T25098	3164-3169	Protein	denotes	TGF-β
T25099	3188-3198	Positive_regulation	denotes	increasing
T25100	3216-3220	Protein	denotes	IL-4
T25101	3296-3299	Protein	denotes	CD4
T25102	3300-3306	Protein	denotes	CD45RA
T25103	3361-3364	Protein	denotes	CD3
T25104	3365-3369	Protein	denotes	CD28
T25105	3371-3376	Protein	denotes	TGF-β
T25106	3392-3396	Protein	denotes	IL-4
T25107	3494-3508	Phosphorylation	denotes	phosphorylated
T25108	3509-3514	Protein	denotes	SMAD2
T25109	3519-3524	Protein	denotes	STAT6
T25110	3532-3537	Protein	denotes	STAT6
T25111	3542-3547	Protein	denotes	GAPDH
T25112	3594-3599	Protein	denotes	GATA3
T25113	3604-3609	Protein	denotes	FOXP3
T25114	3610-3618	Gene_expression	denotes	staining
T25115	3647-3650	Protein	denotes	CD4
T25116	3651-3657	Protein	denotes	CD45RA
T25117	3670-3674	Protein	denotes	IL-4
R4831	T6295	T6296	causeOf	IL-4,inhibit
R4832	T6297	T6298	causeOf	TGF-β,induction
R4833	T6298	T6296	themeOf	induction,inhibit
R4834	T6299	T6298	themeOf	FOXP3,induction
R4835	T6306	T6307	causeOf	IL-4,repressed
R4836	T6308	T6309	causeOf	TGF-β,induction
R4837	T6310	T6311	themeOf	FOXP3,expression
R4838	T6311	T6309	themeOf	expression,induction
R4839	T6312	T6313	themeOf	GATA3,induced
R4840	T6314	T6313	causeOf	absence,induced
R4841	T6315	T6314	themeOf	IL-4,absence
R4842	T6316	T6317	causeOf	IL-4,induce
R4843	T6318	T6319	themeOf	FOXP3,expression
R4844	T6319	T6317	themeOf	expression,induce
R4845	T6320	T6321	themeOf	GATA3,induced
R4846	T6322	T6321	causeOf	TGF-β,induced
R4847	T6323	T6321	causeOf	high,induced
R4848	T6324	T6321	causeOf	IL-4,induced
R4849	T6325	T6326	causeOf	IL-4,prevention
R4850	T6326	T6329	themeOf	prevention,caused
R4851	T6327	T6328	themeOf	FOXP3,expression
R4852	T6328	T6326	themeOf	expression,prevention
R4853	T6328	T6329	themeOf	expression,caused
R4854	T6330	T6333	themeOf	phosphorylation,affected
R4855	T6331	T6330	themeOf	SMAD2,phosphorylation
R4856	T6332	T6330	themeOf	STAT6,phosphorylation
R4857	T6334	T6333	causeOf	IL-4,affected
R4858	T6335	T6333	causeOf	TGF-β,affected
R4859	T6340	T6339	themeOf	GATA3,increase
R4860	T6341	T6342	themeOf	FOXP3,decreased
R4861	T6345	T6344	themeOf	CD25,express
R4862	T6347	T6346	equivalentTo	rmIL-4,IL-4
R4863	T6364	T6363	themeOf	IL-4,effects
R4864	T6367	T6368	themeOf	FOXP3,expression
R4865	T6369	T6370	causeOf	IL-4,inhibit
R4866	T6371	T6372	themeOf	FOXP3,expression
R4867	T6372	T6370	themeOf	expression,inhibit
R4868	T6374	T6375	themeOf	FOXP3,expression
R4869	T6375	T6373	themeOf	expression,decrease
R4870	T6376	T6373	causeOf	IL-4,decrease
R18693	T25091	T25090	causeOf	IL-4,Effect
R18694	T25092	T25093	themeOf	FOXP3,Induction
R18695	T25093	T25090	themeOf	Induction,Effect
R18696	T25100	T25099	themeOf	IL-4,increasing
R18697	T25108	T25107	themeOf	SMAD2,phosphorylated
R18698	T25109	T25107	themeOf	STAT6,phosphorylated
R18699	T25112	T25114	themeOf	GATA3,staining
R18700	T25113	T25114	themeOf	FOXP3,staining

PMC:2222968 / 13785-17546 JSONTXT

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PMC:2222968 / 13785-17546 JSON TXT