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7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells\nMTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes. Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations. The results are the mean ± SEM of triplicate samples. Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed. This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.\nF"}

{"project":"GO-BP","denotations":[{"id":"T24800","span":{"begin":62,"end":68},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T24801","span":{"begin":332,"end":336},"obj":"http://purl.obolibrary.org/obo/GO_0004708"},{"id":"T24802","span":{"begin":348,"end":351},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T24803","span":{"begin":573,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0010309"}],"text":"Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells\nMTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes. Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations. The results are the mean ± SEM of triplicate samples. Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed. This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.\nF"}

{"project":"GO-MF","denotations":[{"id":"T25136","span":{"begin":332,"end":336},"obj":"http://purl.obolibrary.org/obo/GO_0004708"},{"id":"T25137","span":{"begin":348,"end":351},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T25138","span":{"begin":573,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0010309"}],"text":"Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells\nMTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes. Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations. The results are the mean ± SEM of triplicate samples. Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed. This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.\nF"}

{"project":"sentences","denotations":[{"id":"T24794","span":{"begin":10,"end":99},"obj":"Sentence"},{"id":"T24795","span":{"begin":100,"end":224},"obj":"Sentence"},{"id":"T24796","span":{"begin":225,"end":432},"obj":"Sentence"},{"id":"T24797","span":{"begin":433,"end":486},"obj":"Sentence"},{"id":"T24798","span":{"begin":487,"end":635},"obj":"Sentence"},{"id":"T24799","span":{"begin":636,"end":720},"obj":"Sentence"},{"id":"T209","span":{"begin":0,"end":99},"obj":"Sentence"},{"id":"T210","span":{"begin":100,"end":224},"obj":"Sentence"},{"id":"T211","span":{"begin":225,"end":432},"obj":"Sentence"},{"id":"T212","span":{"begin":433,"end":486},"obj":"Sentence"},{"id":"T213","span":{"begin":487,"end":635},"obj":"Sentence"},{"id":"T214","span":{"begin":636,"end":720},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells\nMTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes. Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations. The results are the mean ± SEM of triplicate samples. Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed. This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.\nF"}

{"project":"events-check-again","denotations":[{"id":"T25191","span":{"begin":10,"end":13},"obj":"Protein"},{"id":"T25192","span":{"begin":25,"end":30},"obj":"Protein"},{"id":"T25193","span":{"begin":156,"end":160},"obj":"Protein"},{"id":"T25194","span":{"begin":196,"end":200},"obj":"Protein"},{"id":"T25195","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25196","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25197","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25198","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25199","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25200","span":{"begin":295,"end":299},"obj":"Protein"},{"id":"T25201","span":{"begin":313,"end":316},"obj":"Protein"},{"id":"T25202","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T25203","span":{"begin":337,"end":338},"obj":"Protein"},{"id":"T25204","span":{"begin":367,"end":372},"obj":"Protein"},{"id":"T25205","span":{"begin":548,"end":552},"obj":"Protein"},{"id":"T25206","span":{"begin":605,"end":609},"obj":"Protein"},{"id":"T25207","span":{"begin":668,"end":672},"obj":"Protein"}],"relations":[{"id":"R19552","pred":"themeOf","subj":"T25200","obj":"T25198"},{"id":"R19553","pred":"themeOf","subj":"T25201","obj":"T25197"},{"id":"R19554","pred":"themeOf","subj":"T25202","obj":"T25196"},{"id":"R19555","pred":"themeOf","subj":"T25203","obj":"T25195"},{"id":"R19556","pred":"themeOf","subj":"T25204","obj":"T25199"}],"text":"Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells\nMTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes. Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations. The results are the mean ± SEM of triplicate samples. Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed. This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.\nF"}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T25173","span":{"begin":10,"end":13},"obj":"Protein"},{"id":"T25174","span":{"begin":15,"end":19},"obj":"Protein"},{"id":"T25175","span":{"begin":25,"end":30},"obj":"Protein"},{"id":"T25176","span":{"begin":196,"end":200},"obj":"Protein"},{"id":"T25177","span":{"begin":281,"end":285},"obj":"Protein"},{"id":"T25178","span":{"begin":287,"end":292},"obj":"Protein"},{"id":"T25179","span":{"begin":295,"end":299},"obj":"Protein"},{"id":"T25180","span":{"begin":301,"end":310},"obj":"Protein"},{"id":"T25181","span":{"begin":348,"end":351},"obj":"Protein"},{"id":"T25182","span":{"begin":353,"end":361},"obj":"Protein"},{"id":"T25183","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25184","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25185","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25186","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25187","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25188","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T25189","span":{"begin":605,"end":609},"obj":"Protein"},{"id":"T25190","span":{"begin":668,"end":672},"obj":"Protein"}],"relations":[{"id":"R19546","pred":"themeOf","subj":"T25177","obj":"T25183"},{"id":"R19547","pred":"themeOf","subj":"T25178","obj":"T25184"},{"id":"R19548","pred":"themeOf","subj":"T25179","obj":"T25185"},{"id":"R19549","pred":"themeOf","subj":"T25180","obj":"T25186"},{"id":"R19550","pred":"themeOf","subj":"T25181","obj":"T25187"},{"id":"R19551","pred":"themeOf","subj":"T25182","obj":"T25188"}],"text":"Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells\nMTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes. Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations. The results are the mean ± SEM of triplicate samples. Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed. This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.\nF"}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T24790","span":{"begin":367,"end":372},"obj":"Protein"},{"id":"T24791","span":{"begin":548,"end":552},"obj":"Protein"},{"id":"T24792","span":{"begin":605,"end":609},"obj":"Protein"},{"id":"T24793","span":{"begin":668,"end":672},"obj":"Protein"},{"id":"T24777","span":{"begin":10,"end":13},"obj":"Protein"},{"id":"T24778","span":{"begin":25,"end":30},"obj":"Protein"},{"id":"T24779","span":{"begin":156,"end":160},"obj":"Protein"},{"id":"T24780","span":{"begin":196,"end":200},"obj":"Protein"},{"id":"T24781","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T24782","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T24783","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T24784","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T24785","span":{"begin":267,"end":277},"obj":"Negative_regulation"},{"id":"T24786","span":{"begin":295,"end":299},"obj":"Protein"},{"id":"T24787","span":{"begin":313,"end":316},"obj":"Protein"},{"id":"T24788","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T24789","span":{"begin":337,"end":338},"obj":"Protein"}],"relations":[{"id":"R19225","pred":"themeOf","subj":"T24787","obj":"T24783"},{"id":"R19226","pred":"themeOf","subj":"T24788","obj":"T24782"},{"id":"R19227","pred":"themeOf","subj":"T24789","obj":"T24781"},{"id":"R19228","pred":"themeOf","subj":"T24790","obj":"T24785"},{"id":"R19224","pred":"themeOf","subj":"T24786","obj":"T24784"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells\nMTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes. Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations. The results are the mean ± SEM of triplicate samples. Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed. This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.\nF"}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T24955","span":{"begin":10,"end":13},"obj":"Q9Y243"},{"id":"T24956","span":{"begin":10,"end":13},"obj":"P31751"},{"id":"T24957","span":{"begin":10,"end":13},"obj":"P31749"},{"id":"T24958","span":{"begin":25,"end":30},"obj":"P40763"},{"id":"T24959","span":{"begin":156,"end":160},"obj":"P03230"},{"id":"T24960","span":{"begin":196,"end":200},"obj":"P03230"},{"id":"T24961","span":{"begin":295,"end":299},"obj":"P42345"},{"id":"T24962","span":{"begin":313,"end":316},"obj":"P31749"},{"id":"T24963","span":{"begin":313,"end":316},"obj":"P31751"},{"id":"T24964","span":{"begin":313,"end":316},"obj":"Q9Y243"},{"id":"T24965","span":{"begin":332,"end":336},"obj":"Q02750"},{"id":"T24966","span":{"begin":348,"end":351},"obj":"P53778"},{"id":"T24967","span":{"begin":348,"end":351},"obj":"Q15759"},{"id":"T24968","span":{"begin":348,"end":351},"obj":"Q16539"},{"id":"T24969","span":{"begin":348,"end":351},"obj":"O15264"},{"id":"T24970","span":{"begin":367,"end":372},"obj":"P40763"},{"id":"T24971","span":{"begin":548,"end":552},"obj":"P03230"},{"id":"T24972","span":{"begin":605,"end":609},"obj":"P03230"},{"id":"T24973","span":{"begin":668,"end":672},"obj":"P03230"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells\nMTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes. Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations. The results are the mean ± SEM of triplicate samples. Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed. This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.\nF"}

{"project":"test2","denotations":[{"id":"T24765","span":{"begin":10,"end":13},"obj":"Protein"},{"id":"T24766","span":{"begin":25,"end":30},"obj":"Protein"},{"id":"T24767","span":{"begin":156,"end":160},"obj":"Protein"},{"id":"T24768","span":{"begin":196,"end":200},"obj":"Protein"},{"id":"T24769","span":{"begin":295,"end":299},"obj":"Protein"},{"id":"T24770","span":{"begin":313,"end":316},"obj":"Protein"},{"id":"T24771","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T24772","span":{"begin":337,"end":338},"obj":"Protein"},{"id":"T24773","span":{"begin":367,"end":372},"obj":"Protein"},{"id":"T24774","span":{"begin":548,"end":552},"obj":"Protein"},{"id":"T24775","span":{"begin":605,"end":609},"obj":"Protein"},{"id":"T24776","span":{"begin":668,"end":672},"obj":"Protein"}],"text":"Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells\nMTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes. Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations. The results are the mean ± SEM of triplicate samples. Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed. This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.\nF"}