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2_test

Id Subject Object Predicate Lexical cue
17997602-15231645-98185739 875-877 15231645 denotes 46
17997602-10811897-98185740 2928-2930 10811897 denotes 17
17997602-15047827-98185741 2931-2933 15047827 denotes 18
17997602-12649187-98185742 3707-3709 12649187 denotes 47
17997602-12649187-98185743 3910-3912 12649187 denotes 47
17997602-9882303-98185744 4541-4543 9882303 denotes 13
17997602-10347160-98185745 4544-4546 10347160 denotes 48

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T11981 481-484 DT denotes the
T11897 0-4 NN denotes LMP1
T11898 5-13 VB denotes Promotes
T11899 14-19 NN denotes Tumor
T11900 20-26 NN denotes Growth
T11901 27-30 CC denotes and
T11902 31-39 NN denotes Survival
T11903 40-47 IN denotes through
T11904 48-58 NN denotes Activation
T11905 59-61 IN denotes of
T11906 62-65 NN denotes Akt
T11907 65-66 -COMMA- denotes ,
T11908 67-71 NN denotes NFκB
T11909 71-72 -COMMA- denotes ,
T11910 73-76 CC denotes and
T11911 77-82 NN denotes Stat3
T11912 83-91 NN denotes Pathways
T11913 92-94 TO denotes To
T11914 95-102 VB denotes explore
T11915 103-108 WDT denotes which
T11916 109-117 NN denotes pathways
T11917 118-122 VB denotes were
T11918 123-131 VB denotes required
T11919 132-135 IN denotes for
T11920 136-139 DT denotes the
T11921 140-148 VB denotes enhanced
T11922 149-155 NN denotes growth
T11923 156-159 CC denotes and
T11924 160-168 NN denotes survival
T11925 169-171 IN denotes of
T11926 172-184 JJ denotes LMP1-induced
T11927 185-194 NN denotes lymphomas
T11928 194-195 -COMMA- denotes ,
T11929 196-207 NN denotes splenocytes
T11930 208-212 IN denotes from
T11931 213-222 JJ denotes wild-type
T11932 223-226 CC denotes and
T11933 227-231 NN denotes LMP1
T11934 232-242 JJ denotes transgenic
T11935 243-247 NN denotes mice
T11936 248-252 VB denotes were
T11937 253-261 VB denotes cultured
T11938 262-264 IN denotes in
T11939 265-268 DT denotes the
T11940 269-277 NN denotes presence
T11941 278-280 IN denotes of
T11942 281-291 NN denotes inhibitors
T11943 292-295 IN denotes for
T11944 296-299 NN denotes Akt
T11945 299-300 -COMMA- denotes ,
T11946 301-305 NN denotes NFκB
T11947 305-306 -COMMA- denotes ,
T11948 307-312 NN denotes Stat3
T11949 312-313 -COMMA- denotes ,
T11950 314-318 NN denotes mTOR
T11951 318-319 -COMMA- denotes ,
T11952 320-322 CC denotes or
T11953 323-327 NN denotes MAPK
T11954 328-331 CC denotes and
T11955 332-339 VB denotes assayed
T11956 340-343 IN denotes for
T11957 344-350 NN denotes growth
T11958 351-354 CC denotes and
T11959 355-363 NN denotes survival
T11960 364-366 IN denotes by
T11961 367-370 DT denotes the
T11962 371-374 NN denotes MTS
T11963 375-380 NN denotes assay
T11964 382-384 IN denotes As
T11965 385-395 RB denotes previously
T11966 396-401 VB denotes shown
T11967 401-402 -COMMA- denotes ,
T11968 403-412 JJ denotes wild-type
T11969 413-424 NN denotes lymphocytes
T11970 425-429 VB denotes were
T11971 430-433 RB denotes not
T11972 434-440 JJ denotes viable
T11973 441-443 IN denotes in
T11974 444-451 NN denotes culture
T11975 452-455 CC denotes and
T11976 456-461 MD denotes could
T11977 462-465 RB denotes not
T11978 466-468 VB denotes be
T11979 469-475 VB denotes tested
T11980 476-480 IN denotes with
T11982 485-495 NN denotes inhibitors
T11983 497-504 RB denotes However
T11984 504-505 -COMMA- denotes ,
T11985 506-509 DT denotes the
T11986 510-518 VB denotes enhanced
T11987 519-528 NN denotes viability
T11988 529-531 IN denotes of
T11989 532-536 NN denotes LMP1
T11990 537-547 JJ denotes transgenic
T11991 548-559 NN denotes lymphocytes
T11992 560-563 VB denotes was
T11993 564-575 RB denotes effectively
T11994 576-583 VB denotes blocked
T11995 584-586 IN denotes by
T11996 587-596 NN denotes treatment
T11997 597-601 IN denotes with
T11998 602-613 NN denotes triciribine
T11999 613-614 -COMMA- denotes ,
T12000 615-625 NN denotes BAY11–7085
T12001 625-626 -COMMA- denotes ,
T12002 627-639 NN denotes cucurbitacin
T12003 640-641 NN denotes I
T12004 641-642 -COMMA- denotes ,
T12005 643-646 CC denotes and
T12006 647-655 RB denotes slightly
T12007 656-660 IN denotes with
T12008 661-669 NN denotes SB203580
T12009 669-670 -COMMA- denotes ,
T12010 671-674 CC denotes but
T12011 675-678 RB denotes not
T12012 679-681 IN denotes by
T12013 682-691 NN denotes treatment
T12014 692-696 IN denotes with
T12015 697-706 NN denotes rapamycin
T12016 706-707 -COMMA- denotes ,
T12017 708-713 NN denotes U0126
T12018 713-714 -COMMA- denotes ,
T12019 715-717 CC denotes or
T12020 718-723 NN denotes AG490
T12021 724-725 -LRB- denotes (
T12022 725-731 NN denotes Figure
T12023 732-733 CD denotes 7
T12024 733-734 -RRB- denotes )
T12025 736-747 NN denotes Triciribine
T12026 748-756 VB denotes inhibits
T12027 757-760 DT denotes the
T12028 761-771 NN denotes activation
T12029 772-774 IN denotes of
T12030 775-778 NN denotes Akt
T12031 779-782 CC denotes and
T12032 783-785 IN denotes at
T12033 786-788 CD denotes 20
T12034 789-791 NN denotes μM
T12035 792-795 VB denotes has
T12036 796-800 VB denotes been
T12037 801-806 VB denotes shown
T12038 807-809 TO denotes to
T12039 810-816 VB denotes induce
T12040 817-823 NN denotes growth
T12041 824-830 NN denotes arrest
T12042 831-833 IN denotes in
T12043 834-840 NN denotes cancer
T12044 841-846 NN denotes cells
T12045 847-851 IN denotes with
T12046 852-860 JJ denotes aberrant
T12047 861-864 NN denotes Akt
T12048 865-873 NN denotes activity
T12049 874-875 -LRB- denotes [
T12050 875-877 CD denotes 46
T12051 877-878 -RRB- denotes ]
T12052 880-883 DT denotes The
T12053 884-891 NN denotes effects
T12054 892-894 IN denotes of
T12055 895-906 NN denotes triciribine
T12056 907-909 IN denotes on
T12057 910-914 NN denotes cell
T12058 915-921 NN denotes growth
T12059 922-924 IN denotes of
T12060 925-928 DT denotes the
T12061 929-939 JJ denotes transgenic
T12062 940-951 NN denotes lymphocytes
T12063 952-955 CC denotes and
T12064 956-965 NN denotes lymphomas
T12065 966-970 VB denotes were
T12066 971-979 JJ denotes apparent
T12067 980-982 RB denotes as
T12068 983-986 JJ denotes low
T12069 987-989 IN denotes as
T12070 990-991 CD denotes 1
T12071 992-994 NN denotes μM
T12072 994-995 -COMMA- denotes ,
T12073 996-1006 VB denotes suggesting
T12074 1007-1011 IN denotes that
T12075 1012-1022 NN denotes activation
T12076 1023-1025 IN denotes of
T12077 1026-1029 NN denotes Akt
T12078 1030-1032 VB denotes is
T12079 1033-1041 VB denotes required
T12080 1042-1045 IN denotes for
T12081 1046-1049 DT denotes the
T12082 1050-1058 NN denotes survival
T12083 1059-1062 CC denotes and
T12084 1063-1069 NN denotes growth
T12085 1070-1072 IN denotes of
T12086 1073-1077 NN denotes LMP1
T12087 1078-1088 JJ denotes transgenic
T12088 1089-1100 NN denotes lymphocytes
T12089 1101-1104 CC denotes and
T12090 1105-1113 NN denotes lymphoma
T12091 1114-1119 NN denotes cells
T12092 1120-1121 -LRB- denotes (
T12093 1121-1127 NN denotes Figure
T12094 1128-1129 CD denotes 7
T12095 1129-1130 -RRB- denotes )
T12096 1132-1135 DT denotes The
T12097 1136-1143 NN denotes effects
T12098 1144-1146 IN denotes of
T12099 1147-1150 DT denotes the
T12100 1151-1161 NN denotes inhibitors
T12101 1162-1166 VB denotes were
T12102 1167-1175 VB denotes assessed
T12103 1176-1178 IN denotes by
T12104 1179-1190 VB denotes identifying
T12105 1191-1205 VB denotes phosphorylated
T12106 1206-1209 NN denotes Akt
T12107 1209-1210 -COMMA- denotes ,
T12108 1211-1216 NN denotes Stat3
T12109 1216-1217 -COMMA- denotes ,
T12110 1218-1221 CC denotes and
T12111 1222-1227 JJ denotes total
T12112 1228-1234 NN denotes levels
T12113 1235-1237 IN denotes of
T12114 1238-1242 NN denotes IκBα
T12115 1243-1244 -LRB- denotes (
T12116 1244-1250 NN denotes Figure
T12117 1251-1252 CD denotes 8
T12118 1252-1253 -RRB- denotes )
T12119 1255-1264 NN denotes Treatment
T12120 1265-1269 IN denotes with
T12121 1270-1281 NN denotes triciribine
T12122 1282-1293 RB denotes effectively
T12123 1294-1301 VB denotes blocked
T12124 1302-1317 NN denotes phosphorylation
T12125 1318-1320 IN denotes of
T12126 1321-1324 NN denotes Akt
T12127 1324-1325 -COMMA- denotes ,
T12128 1326-1329 CC denotes and
T12129 1330-1344 VB denotes phosphorylated
T12130 1345-1348 NN denotes Akt
T12131 1349-1352 VB denotes was
T12132 1353-1355 RB denotes no
T12133 1356-1362 RB denotes longer
T12134 1363-1371 VB denotes detected
T12135 1372-1376 IN denotes past
T12136 1377-1378 CD denotes 5
T12137 1379-1381 NN denotes μM
T12138 1383-1397 VB denotes Phosphorylated
T12139 1398-1403 NN denotes Stat3
T12140 1404-1407 CC denotes and
T12141 1408-1412 NN denotes IκBα
T12142 1413-1417 VB denotes were
T12143 1418-1423 RB denotes still
T12144 1424-1431 JJ denotes present
T12145 1432-1434 IN denotes at
T12146 1435-1437 CD denotes 25
T12147 1438-1440 NN denotes μM
T12148 1442-1447 DT denotes These
T12149 1448-1456 NN denotes findings
T12150 1457-1464 VB denotes suggest
T12151 1465-1469 IN denotes that
T12152 1470-1481 NN denotes triciribine
T12153 1482-1494 RB denotes specifically
T12154 1495-1502 VB denotes targets
T12155 1503-1506 NN denotes Akt
T12156 1507-1510 CC denotes and
T12157 1511-1515 IN denotes that
T12158 1516-1519 NN denotes Akt
T12159 1520-1530 NN denotes activation
T12160 1531-1533 VB denotes is
T12161 1534-1542 VB denotes required
T12162 1543-1546 IN denotes for
T12163 1547-1550 DT denotes the
T12164 1551-1559 VB denotes enhanced
T12165 1560-1569 NN denotes viability
T12166 1570-1572 IN denotes of
T12167 1573-1576 DT denotes the
T12168 1577-1587 JJ denotes transgenic
T12169 1588-1599 NN denotes lymphocytes
T12170 1600-1603 CC denotes and
T12171 1604-1612 NN denotes lymphoma
T12172 1613-1618 NN denotes cells
T12173 2840-2850 NN denotes Inhibition
T12174 2851-2853 IN denotes of
T12175 2854-2858 NN denotes NFκB
T12176 2859-2868 NN denotes signaling
T12177 2869-2876 RB denotes rapidly
T12178 2877-2884 VB denotes induces
T12179 2885-2889 NN denotes cell
T12180 2890-2895 NN denotes death
T12181 2896-2898 IN denotes of
T12182 2899-2914 JJ denotes EBV-transformed
T12183 2915-2926 NN denotes lymphocytes
T12184 2927-2928 -LRB- denotes [
T12185 2928-2933 CD denotes 17,18
T12186 2933-2934 -RRB- denotes ]
T12187 2936-2946 NN denotes BAY11–7085
T12188 2946-2947 -COMMA- denotes ,
T12189 2948-2950 DT denotes an
T12190 2951-2960 NN denotes inhibitor
T12191 2961-2963 IN denotes of
T12192 2964-2968 NN denotes NFκB
T12193 2969-2978 NN denotes signaling
T12194 2978-2979 -COMMA- denotes ,
T12195 2980-2984 RB denotes also
T12196 2985-2992 RB denotes greatly
T12197 2993-3002 VB denotes decreased
T12198 3003-3006 DT denotes the
T12199 3007-3016 NN denotes viability
T12200 3017-3019 IN denotes of
T12201 3020-3023 DT denotes the
T12202 3024-3028 NN denotes LMP1
T12203 3029-3039 JJ denotes transgenic
T12204 3040-3051 NN denotes lymphocytes
T12205 3052-3055 CC denotes and
T12206 3056-3064 NN denotes lymphoma
T12207 3065-3070 NN denotes cells
T12208 3071-3073 IN denotes at
T12209 3074-3079 NN denotes doses
T12210 3080-3082 RB denotes as
T12211 3083-3086 JJ denotes low
T12212 3087-3089 IN denotes as
T12213 3090-3091 CD denotes 1
T12214 3092-3094 NN denotes μM
T12215 3094-3095 -COMMA- denotes ,
T12216 3096-3099 CC denotes and
T12217 3100-3102 IN denotes at
T12218 3103-3104 CD denotes 5
T12219 3105-3107 NN denotes μM
T12220 3108-3111 DT denotes the
T12221 3112-3117 NN denotes cells
T12222 3118-3122 VB denotes were
T12223 3123-3133 RB denotes completely
T12224 3134-3143 JJ denotes nonviable
T12225 3144-3145 -LRB- denotes (
T12226 3145-3151 NN denotes Figure
T12227 3152-3153 CD denotes 7
T12228 3153-3154 -RRB- denotes )
T12229 3156-3160 DT denotes This
T12230 3161-3163 VB denotes is
T12231 3164-3168 RB denotes well
T12232 3169-3175 IN denotes within
T12233 3176-3179 DT denotes the
T12234 3180-3188 VB denotes reported
T12235 3189-3193 NN denotes IC50
T12236 3194-3196 IN denotes of
T12237 3197-3199 CD denotes 10
T12238 3200-3202 NN denotes μM
T12239 3204-3218 VB denotes Phosphorylated
T12240 3219-3222 NN denotes Akt
T12241 3222-3223 -COMMA- denotes ,
T12242 3224-3229 NN denotes Stat3
T12243 3229-3230 -COMMA- denotes ,
T12244 3231-3234 CC denotes and
T12245 3235-3240 JJ denotes total
T12246 3241-3245 NN denotes IκBα
T12247 3246-3250 VB denotes were
T12248 3251-3256 RB denotes still
T12249 3257-3264 JJ denotes present
T12250 3265-3267 IN denotes up
T12251 3268-3270 TO denotes to
T12252 3271-3280 NN denotes treatment
T12253 3281-3285 IN denotes with
T12254 3286-3288 CD denotes 15
T12255 3289-3291 NN denotes μM
T12256 3292-3295 CC denotes and
T12257 3296-3300 RB denotes then
T12258 3301-3305 VB denotes were
T12259 3306-3308 RB denotes no
T12260 3309-3315 RB denotes longer
T12261 3316-3324 VB denotes detected
T12262 3325-3326 -LRB- denotes (
T12263 3326-3332 NN denotes Figure
T12264 3333-3334 CD denotes 8
T12265 3334-3335 -RRB- denotes )
T12266 3337-3341 DT denotes This
T12267 3342-3349 NN denotes finding
T12268 3350-3358 VB denotes suggests
T12269 3359-3363 IN denotes that
T12270 3364-3374 NN denotes inhibition
T12271 3375-3377 IN denotes of
T12272 3378-3382 NN denotes NFκB
T12273 3383-3386 MD denotes can
T12274 3387-3393 VB denotes induce
T12275 3394-3398 NN denotes cell
T12276 3399-3404 NN denotes death
T12277 3405-3407 IN denotes in
T12278 3408-3412 NN denotes LMP1
T12279 3413-3423 JJ denotes transgenic
T12280 3424-3435 NN denotes lymphocytes
T12281 3436-3439 CC denotes and
T12282 3440-3448 NN denotes lymphoma
T12283 3449-3454 NN denotes cells
T12284 3455-3462 IN denotes without
T12285 3463-3474 JJ denotes significant
T12286 3475-3482 NN denotes effects
T12287 3483-3485 IN denotes on
T12288 3486-3496 NN denotes activation
T12289 3497-3499 IN denotes of
T12290 3500-3503 NN denotes Akt
T12291 3504-3506 CC denotes or
T12292 3507-3512 NN denotes Stat3
T12293 3514-3526 NN denotes Cucurbitacin
T12294 3527-3528 PRP denotes I
T12295 3529-3537 VB denotes inhibits
T12296 3538-3548 NN denotes activation
T12297 3549-3551 IN denotes of
T12298 3552-3557 NN denotes Stat3
T12299 3558-3560 IN denotes by
T12300 3561-3572 VB denotes suppressing
T12301 3573-3576 DT denotes the
T12302 3577-3587 NN denotes activation
T12303 3588-3590 IN denotes of
T12304 3591-3594 PRP-DOLLAR- denotes its
T12305 3595-3601 NN denotes kinase
T12306 3602-3606 NN denotes JAK2
T12307 3608-3610 PRP denotes It
T12308 3611-3614 VB denotes has
T12309 3615-3619 VB denotes been
T12310 3620-3625 VB denotes shown
T12311 3626-3628 TO denotes to
T12312 3629-3640 RB denotes selectively
T12313 3641-3648 VB denotes inhibit
T12314 3649-3652 DT denotes the
T12315 3653-3659 NN denotes growth
T12316 3660-3662 IN denotes of
T12317 3663-3669 NN denotes tumors
T12318 3670-3674 IN denotes with
T12319 3675-3689 RB denotes constitutively
T12320 3690-3699 VB denotes activated
T12321 3700-3705 NN denotes Stat3
T12322 3706-3707 -LRB- denotes [
T12323 3707-3709 CD denotes 47
T12324 3709-3710 -RRB- denotes ]
T12325 3712-3721 RB denotes Similarly
T12326 3721-3722 -COMMA- denotes ,
T12327 3723-3727 NN denotes LMP1
T12328 3728-3738 JJ denotes transgenic
T12329 3739-3750 NN denotes lymphocytes
T12330 3751-3754 CC denotes and
T12331 3755-3763 NN denotes lymphoma
T12332 3764-3769 NN denotes cells
T12333 3770-3774 VB denotes were
T12334 3775-3786 JJ denotes susceptible
T12335 3787-3789 TO denotes to
T12336 3790-3802 NN denotes cucurbitacin
T12337 3803-3804 CD denotes I
T12338 3805-3814 NN denotes treatment
T12339 3815-3823 VB denotes starting
T12340 3824-3826 IN denotes at
T12341 3827-3830 CD denotes 0.1
T12342 3831-3833 NN denotes μM
T12343 3833-3834 -COMMA- denotes ,
T12344 3835-3836 DT denotes a
T12345 3837-3841 NN denotes dose
T12346 3842-3846 WDT denotes that
T12347 3847-3858 VB denotes corresponds
T12348 3859-3866 RB denotes closely
T12349 3867-3869 TO denotes to
T12350 3870-3873 DT denotes the
T12351 3874-3882 VB denotes reported
T12352 3883-3887 NN denotes IC50
T12353 3888-3890 IN denotes of
T12354 3891-3894 CD denotes 500
T12355 3895-3897 NN denotes nM
T12356 3898-3899 -LRB- denotes (
T12357 3899-3905 NN denotes Figure
T12358 3906-3907 CD denotes 7
T12359 3907-3908 -RRB- denotes )
T12360 3909-3910 -LRB- denotes [
T12361 3910-3912 CD denotes 47
T12362 3912-3913 -RRB- denotes ]
T12363 3915-3929 VB denotes Phosphorylated
T12364 3930-3933 NN denotes Akt
T12365 3933-3934 -COMMA- denotes ,
T12366 3935-3940 NN denotes Stat3
T12367 3940-3941 -COMMA- denotes ,
T12368 3942-3945 CC denotes and
T12369 3946-3951 JJ denotes total
T12370 3952-3956 NN denotes IκBα
T12371 3957-3961 VB denotes were
T12372 3962-3965 RB denotes not
T12373 3966-3976 JJ denotes detectable
T12374 3977-3981 IN denotes past
T12375 3982-3983 CD denotes 1
T12376 3984-3986 NN denotes μM
T12377 3987-3990 CC denotes and
T12378 3991-3993 IN denotes at
T12379 3994-4000 JJ denotes higher
T12380 4001-4006 NN denotes doses
T12381 4007-4010 DT denotes all
T12382 4011-4018 NN denotes protein
T12383 4019-4025 NN denotes levels
T12384 4026-4030 VB denotes were
T12385 4031-4038 RB denotes greatly
T12386 4039-4048 VB denotes decreased
T12387 4048-4049 -COMMA- denotes ,
T12388 4050-4060 JJ denotes indicative
T12389 4061-4063 IN denotes of
T12390 4064-4067 DT denotes the
T12391 4068-4073 JJ denotes total
T12392 4074-4078 NN denotes loss
T12393 4079-4081 IN denotes of
T12394 4082-4091 NN denotes viability
T12395 4092-4093 -LRB- denotes (
T12396 4093-4099 NN denotes Figure
T12397 4100-4101 CD denotes 8
T12398 4101-4102 -RRB- denotes )
T12399 4104-4105 DT denotes A
T12400 4106-4112 JJ denotes second
T12401 4113-4121 VB denotes reported
T12402 4122-4131 NN denotes inhibitor
T12403 4132-4134 IN denotes of
T12404 4135-4140 NN denotes Stat3
T12405 4140-4141 -COMMA- denotes ,
T12406 4142-4147 NN denotes AG490
T12407 4147-4148 -COMMA- denotes ,
T12408 4149-4152 VB denotes had
T12409 4153-4155 DT denotes no
T12410 4156-4162 NN denotes effect
T12411 4163-4165 IN denotes on
T12412 4166-4172 NN denotes growth
T12413 4173-4174 -LRB- denotes (
T12414 4174-4180 NN denotes Figure
T12415 4181-4182 CD denotes 7
T12416 4182-4183 -RRB- denotes )
T12417 4183-4184 -COMMA- denotes ,
T12418 4185-4188 CC denotes but
T12419 4189-4199 NN denotes activation
T12420 4200-4202 IN denotes of
T12421 4203-4206 NN denotes Akt
T12422 4206-4207 -COMMA- denotes ,
T12423 4208-4213 NN denotes Stat3
T12424 4213-4214 -COMMA- denotes ,
T12425 4215-4217 CC denotes or
T12426 4218-4224 NN denotes levels
T12427 4225-4227 IN denotes of
T12428 4228-4232 NN denotes IκBα
T12429 4233-4237 VB denotes were
T12430 4238-4242 RB denotes also
T12431 4243-4246 RB denotes not
T12432 4247-4255 VB denotes affected
T12433 4256-4257 -LRB- denotes (
T12434 4257-4263 NN denotes Figure
T12435 4264-4265 CD denotes 8
T12436 4265-4266 -RRB- denotes )
T12437 4268-4273 DT denotes These
T12438 4274-4282 NN denotes findings
T12439 4283-4290 VB denotes suggest
T12440 4291-4295 IN denotes that
T12441 4296-4306 NN denotes inhibition
T12442 4307-4309 IN denotes of
T12443 4310-4315 NN denotes Stat3
T12444 4316-4319 MD denotes can
T12445 4320-4326 VB denotes induce
T12446 4327-4331 NN denotes cell
T12447 4332-4337 NN denotes death
T12448 4338-4340 IN denotes in
T12449 4341-4345 NN denotes LMP1
T12450 4346-4356 JJ denotes transgenic
T12451 4357-4368 NN denotes lymphocytes
T12452 4369-4372 CC denotes and
T12453 4373-4381 NN denotes lymphoma
T12454 4382-4387 NN denotes cells
T12455 4387-4388 -COMMA- denotes ,
T12456 4389-4392 CC denotes but
T12457 4393-4398 NN denotes Stat3
T12458 4399-4409 NN denotes inhibition
T12459 4410-4414 RB denotes also
T12460 4415-4418 VB denotes has
T12461 4419-4431 JJ denotes considerable
T12462 4432-4441 JJ denotes crossover
T12463 4442-4449 NN denotes effects
T12464 4450-4452 IN denotes on
T12465 4453-4456 NN denotes Akt
T12466 4457-4460 CC denotes and
T12467 4461-4465 NN denotes NFκB
T12468 4466-4475 NN denotes signaling
T12469 4477-4481 NN denotes LMP1
T12470 4482-4485 VB denotes has
T12471 4486-4490 RB denotes also
T12472 4491-4495 VB denotes been
T12473 4496-4501 VB denotes shown
T12474 4502-4504 TO denotes to
T12475 4505-4513 VB denotes activate
T12476 4514-4517 NN denotes JNK
T12477 4518-4521 CC denotes and
T12478 4522-4525 NN denotes p38
T12479 4526-4530 NN denotes MAPK
T12480 4531-4539 NN denotes pathways
T12481 4540-4541 -LRB- denotes [
T12482 4541-4546 CD denotes 13,48
T12483 4546-4547 -RRB- denotes ]
T12484 4547-4548 -COMMA- denotes ,
T12485 4549-4552 CC denotes and
T12486 4553-4557 NN denotes LMP1
T12487 4558-4568 JJ denotes transgenic
T12488 4569-4580 NN denotes lymphocytes
T12489 4581-4585 VB denotes were
T12490 4586-4592 RB denotes mildly
T12491 4593-4604 JJ denotes susceptible
T12492 4605-4607 TO denotes to
T12493 4608-4614 NN denotes growth
T12494 4615-4625 NN denotes inhibition
T12495 4626-4628 IN denotes by
T12496 4629-4637 NN denotes SB202190
T12497 4637-4638 -COMMA- denotes ,
T12498 4639-4641 DT denotes an
T12499 4642-4651 NN denotes inhibitor
T12500 4652-4654 IN denotes of
T12501 4655-4658 NN denotes p38
T12502 4659-4663 NN denotes MAPK
T12503 4663-4664 -COMMA- denotes ,
T12504 4665-4668 CC denotes but
T12505 4669-4672 RB denotes not
T12506 4673-4678 NN denotes U0126
T12507 4678-4679 -COMMA- denotes ,
T12508 4680-4682 DT denotes an
T12509 4683-4692 NN denotes inhibitor
T12510 4693-4695 IN denotes of
T12511 4696-4702 NN denotes MEK1/2
T12512 4703-4711 NN denotes activity
T12513 4713-4720 RB denotes However
T12514 4720-4721 -COMMA- denotes ,
T12515 4722-4729 NN denotes effects
T12516 4730-4732 IN denotes of
T12517 4733-4741 NN denotes SB202190
T12518 4742-4746 VB denotes were
T12519 4747-4751 RB denotes only
T12520 4752-4760 JJ denotes apparent
T12521 4761-4763 IN denotes at
T12522 4764-4768 JJ denotes high
T12523 4769-4774 NN denotes doses
T12524 4775-4776 -LRB- denotes (
T12525 4776-4777 JJ denotes >
T12526 4777-4779 CD denotes 10
T12527 4780-4782 NN denotes μM
T12528 4782-4783 -RRB- denotes )
T12529 4783-4784 -COMMA- denotes ,
T12530 4785-4789 RB denotes much
T12531 4790-4796 JJ denotes higher
T12532 4797-4801 IN denotes than
T12533 4802-4805 DT denotes the
T12534 4806-4814 VB denotes reported
T12535 4815-4819 NN denotes IC50
T12536 4820-4822 IN denotes of
T12537 4823-4827 CD denotes 0.35
T12538 4828-4830 NN denotes μM
T12539 4830-4831 -COMMA- denotes ,
T12540 4832-4842 VB denotes suggesting
T12541 4843-4847 IN denotes that
T12542 4848-4851 NN denotes p38
T12543 4852-4856 NN denotes MAPK
T12544 4857-4861 VB denotes does
T12545 4862-4865 RB denotes not
T12546 4866-4879 RB denotes significantly
T12547 4880-4890 VB denotes contribute
T12548 4891-4893 TO denotes to
T12549 4894-4897 DT denotes the
T12550 4898-4906 VB denotes enhanced
T12551 4907-4916 NN denotes viability
T12552 4917-4919 IN denotes in
T12553 4920-4924 NN denotes LMP1
T12554 4925-4935 JJ denotes transgenic
T12555 4936-4947 NN denotes lymphocytes
T12556 4948-4950 CC denotes or
T12557 4951-4959 NN denotes lymphoma
T12558 4960-4965 NN denotes cells
T12559 4966-4967 -LRB- denotes (
T12560 4967-4973 NN denotes Figure
T12561 4974-4975 CD denotes 7
T12562 4975-4976 -RRB- denotes )
T12563 4978-4991 RB denotes Interestingly
T12564 4991-4992 -COMMA- denotes ,
T12565 4993-4997 CC denotes both
T12566 4998-5007 JJ denotes wild-type
T12567 5008-5011 CC denotes and
T12568 5012-5016 NN denotes LMP1
T12569 5017-5027 JJ denotes transgenic
T12570 5028-5037 NN denotes lymphomas
T12571 5038-5042 VB denotes were
T12572 5043-5052 RB denotes similarly
T12573 5053-5064 JJ denotes susceptible
T12574 5065-5067 TO denotes to
T12575 5068-5079 NN denotes triciribine
T12576 5079-5080 -COMMA- denotes ,
T12577 5081-5091 NN denotes BAY11–7085
T12578 5091-5092 -COMMA- denotes ,
T12579 5093-5096 CC denotes and
T12580 5097-5109 NN denotes cucurbitacin
T12581 5110-5111 CD denotes I
T12582 5112-5122 NN denotes treatments
T12583 5122-5123 -COMMA- denotes ,
T12584 5124-5127 CC denotes but
T12585 5128-5131 RB denotes not
T12586 5132-5140 NN denotes SB202190
T12587 5140-5141 -COMMA- denotes ,
T12588 5142-5147 NN denotes AG490
T12589 5147-5148 -COMMA- denotes ,
T12590 5149-5151 CC denotes or
T12591 5152-5157 NN denotes U0126
T12592 5158-5167 NN denotes treatment
T12593 5167-5168 -COMMA- denotes ,
T12594 5169-5179 VB denotes suggesting
T12595 5180-5184 IN denotes that
T12596 5185-5195 NN denotes activation
T12597 5196-5198 IN denotes of
T12598 5199-5202 NN denotes Akt
T12599 5202-5203 -COMMA- denotes ,
T12600 5204-5208 NN denotes NFκB
T12601 5208-5209 -COMMA- denotes ,
T12602 5210-5213 CC denotes and
T12603 5214-5219 NN denotes Stat3
T12604 5220-5223 CC denotes but
T12605 5224-5227 RB denotes not
T12606 5228-5232 NN denotes MAPK
T12607 5233-5241 NN denotes pathways
T12608 5242-5245 VB denotes are
T12609 5246-5261 NN denotes characteristics
T12610 5262-5272 VB denotes associated
T12611 5273-5277 IN denotes with
T12612 5278-5287 JJ denotes malignant
T12613 5288-5302 NN denotes transformation
T12614 5303-5304 -LRB- denotes (
T12615 5304-5310 NN denotes Figure
T12616 5311-5312 CD denotes 7
T12617 5312-5313 -RRB- denotes )
T12618 5313-5322 NN denotes . rapamyc
T12619 5322-5323 -COMMA- denotes i
T12620 5323-5325 DT denotes n,
T12621 5326-5335 NN denotes an inhibi
T12622 5335-5337 IN denotes to
T12623 5337-5341 NN denotes r of
T12624 5342-5343 -COMMA- denotes m
T12625 5343-5346 VB denotes TOR
T12626 5346-5349 RB denotes , d
T12627 5349-5355 VB denotes id not
T12628 5356-5359 DT denotes aff
T12629 5359-5368 NN denotes ect the v
T12630 5368-5370 IN denotes ia
T12631 5370-5373 DT denotes bil
T12632 5373-5383 JJ denotes ity of the
T12633 5384-5395 NN denotes transgenic
T12634 5395-5397 CC denotes ly
T12635 5397-5405 NN denotes mphocyte
T12636 5405-5410 NN denotes s or
T12637 5410-5411 -COMMA- denotes l
T12638 5411-5421 VB denotes ymphoma ce
T12639 5421-5425 IN denotes lls,
T12640 5426-5430 NN denotes conf
T12641 5430-5432 VB denotes ir
T12642 5432-5435 RB denotes min
T12643 5435-5443 VB denotes g that m
T12644 5443-5445 IN denotes TO
T12645 5445-5448 NN denotes R i
T12646 5448-5458 NN denotes s not targ
T12647 5458-5460 IN denotes et
T12648 5460-5464 NN denotes ed b
T12649 5464-5474 JJ denotes y Akt acti
T12650 5474-5485 NN denotes vation in L
T12651 5485-5487 CC denotes MP
T12652 5487-5496 JJ denotes 1 transge
T12653 5496-5504 NN denotes nic lymp
T12654 5504-5509 NN denotes hocyt
T12655 5509-5510 -LRB- denotes e
T12656 5510-5516 NN denotes s or m
T12657 5516-5517 CD denotes a
T12658 5517-5518 -RRB- denotes l
T24804 1630-1633 NN denotes Akt
T24805 1633-1634 -COMMA- denotes ,
T24806 1635-1639 NN denotes NFκB
T24807 1639-1640 -COMMA- denotes ,
T24808 1641-1644 CC denotes and
T24809 1645-1650 NN denotes Stat3
T24810 1651-1660 NN denotes Signaling
T24811 1661-1664 VB denotes Are
T24812 1665-1673 VB denotes Required
T24813 1674-1677 IN denotes for
T24814 1678-1681 DT denotes the
T24815 1682-1688 NN denotes Growth
T24816 1689-1692 CC denotes and
T24817 1693-1701 NN denotes Survival
T24818 1702-1704 IN denotes of
T24819 1705-1713 NN denotes Lymphoma
T24820 1714-1719 NN denotes Cells
T24821 1720-1723 NN denotes MTS
T24822 1724-1729 NN denotes assay
T24823 1730-1732 IN denotes of
T24824 1733-1744 NN denotes splenocytes
T24825 1745-1749 IN denotes from
T24826 1750-1751 -LRB- denotes (
T24827 1751-1752 NN denotes A
T24828 1753-1756 CC denotes and
T24829 1757-1758 NN denotes B
T24830 1758-1759 -RRB- denotes )
T24831 1760-1762 NN denotes WT
T24832 1763-1765 CC denotes or
T24833 1766-1767 -LRB- denotes (
T24834 1767-1768 NN denotes C
T24835 1769-1772 CC denotes and
T24836 1773-1774 NN denotes D
T24837 1774-1775 -RRB- denotes )
T24838 1776-1780 NN denotes LMP1
T24839 1781-1791 JJ denotes transgenic
T24840 1792-1801 NN denotes lymphomas
T24841 1802-1805 CC denotes and
T24842 1806-1807 -LRB- denotes (
T24843 1807-1808 NN denotes E
T24844 1809-1812 CC denotes and
T24845 1813-1814 NN denotes F
T24846 1814-1815 -RRB- denotes )
T24847 1816-1820 NN denotes LMP1
T24848 1821-1831 JJ denotes transgenic
T24849 1832-1843 NN denotes lymphoctyes
T24850 1845-1856 NN denotes Splenocytes
T24851 1857-1861 VB denotes were
T24852 1862-1870 VB denotes cultured
T24853 1871-1875 IN denotes with
T24854 1876-1878 CC denotes or
T24855 1879-1886 IN denotes without
T24856 1887-1897 NN denotes inhibitors
T24857 1898-1900 IN denotes of
T24858 1901-1905 NN denotes NFκB
T24859 1906-1907 -LRB- denotes (
T24860 1907-1912 NN denotes BAY11
T24861 1912-1913 -RRB- denotes )
T24862 1913-1914 -COMMA- denotes ,
T24863 1915-1919 NN denotes mTOR
T24864 1920-1921 -LRB- denotes (
T24865 1921-1930 NN denotes rapamycin
T24866 1930-1931 -RRB- denotes )
T24867 1931-1932 -COMMA- denotes ,
T24868 1933-1936 NN denotes Akt
T24869 1937-1938 -LRB- denotes (
T24870 1938-1949 NN denotes triciribine
T24871 1949-1950 -RRB- denotes )
T24872 1950-1951 -COMMA- denotes ,
T24873 1952-1958 NN denotes MEK1/2
T24874 1959-1960 -LRB- denotes (
T24875 1960-1965 NN denotes U0126
T24876 1965-1966 -RRB- denotes )
T24877 1966-1967 -COMMA- denotes ,
T24878 1968-1971 NN denotes p38
T24879 1972-1973 -LRB- denotes (
T24880 1973-1981 NN denotes SB202190
T24881 1981-1982 -RRB- denotes )
T24882 1982-1983 -COMMA- denotes ,
T24883 1984-1986 CC denotes or
T24884 1987-1992 NN denotes Stat3
T24885 1993-1994 -LRB- denotes (
T24886 1994-2006 NN denotes cucurbitacin
T24887 2007-2008 CD denotes I
T24888 2009-2012 CC denotes and
T24889 2013-2018 NN denotes AG490
T24890 2018-2019 -RRB- denotes )
T24891 2020-2022 IN denotes at
T24892 2023-2026 DT denotes the
T24893 2027-2036 VB denotes indicated
T24894 2037-2051 NN denotes concentrations
T24895 2053-2056 DT denotes The
T24896 2057-2064 NN denotes results
T24897 2065-2068 VB denotes are
T24898 2069-2072 DT denotes the
T24899 2073-2077 JJ denotes mean
T24900 2078-2079 JJ denotes ±
T24901 2080-2083 NN denotes SEM
T24902 2084-2086 IN denotes of
T24903 2087-2097 JJ denotes triplicate
T24904 2098-2105 NN denotes samples
T24905 2107-2112 VB denotes Shown
T24906 2113-2116 VB denotes are
T24907 2117-2120 DT denotes the
T24908 2121-2128 NN denotes results
T24909 2129-2132 IN denotes for
T24910 2133-2134 -LRB- denotes (
T24911 2134-2135 NN denotes A
T24912 2136-2139 CC denotes and
T24913 2140-2141 NN denotes B
T24914 2141-2142 -RRB- denotes )
T24915 2143-2145 JJ denotes WT
T24916 2146-2154 NN denotes lymphoma
T24917 2155-2156 CD denotes 1
T24918 2156-2157 -COMMA- denotes ,
T24919 2158-2159 -LRB- denotes (
T24920 2159-2160 NN denotes C
T24921 2161-2164 CC denotes and
T24922 2165-2166 NN denotes D
T24923 2166-2167 -RRB- denotes )
T24924 2168-2172 NN denotes LMP1
T24925 2173-2183 JJ denotes transgenic
T24926 2184-2192 NN denotes lymphoma
T24927 2193-2194 CD denotes 2
T24928 2194-2195 -COMMA- denotes ,
T24929 2196-2199 CC denotes and
T24930 2200-2201 -LRB- denotes (
T24931 2201-2202 NN denotes E
T24932 2203-2206 CC denotes and
T24933 2207-2208 NN denotes F
T24934 2208-2209 -RRB- denotes )
T24935 2210-2213 CD denotes one
T24936 2214-2217 IN denotes out
T24937 2218-2220 IN denotes of
T24938 2221-2224 CD denotes two
T24939 2225-2229 NN denotes LMP1
T24940 2230-2240 JJ denotes transgenic
T24941 2241-2245 NN denotes mice
T24942 2246-2254 VB denotes analyzed
T24943 2256-2260 DT denotes This
T24944 2261-2269 NN denotes analysis
T24945 2270-2273 VB denotes was
T24946 2274-2282 VB denotes repeated
T24947 2283-2287 IN denotes with
T24948 2288-2292 NN denotes LMP1
T24949 2293-2303 JJ denotes transgenic
T24950 2304-2312 NN denotes lymphoma
T24951 2313-2314 CD denotes 4
T24952 2315-2323 NN denotes yielding
T24953 2324-2331 JJ denotes similar
T24954 2332-2339 NN denotes results
T25244 2351-2359 NN denotes Analysis
T25245 2360-2362 IN denotes of
T25246 2363-2366 NN denotes Akt
T25247 2366-2367 -COMMA- denotes ,
T25248 2368-2372 NN denotes NFκB
T25249 2372-2373 -COMMA- denotes ,
T25250 2374-2377 CC denotes and
T25251 2378-2383 NN denotes Stat3
T25252 2384-2392 NN denotes Pathways
T25253 2393-2395 IN denotes in
T25254 2396-2408 NN denotes Contribution
T25255 2409-2411 TO denotes to
T25256 2412-2415 DT denotes the
T25257 2416-2422 NN denotes Growth
T25258 2423-2426 CC denotes and
T25259 2427-2435 NN denotes Survival
T25260 2436-2438 IN denotes of
T25261 2439-2447 NN denotes Lymphoma
T25262 2448-2453 NN denotes Cells
T25263 2454-2455 -LRB- denotes (
T25264 2455-2458 NN denotes A–D
T25265 2458-2459 -RRB- denotes )
T25266 2460-2470 NN denotes Immunoblot
T25267 2471-2479 NN denotes analysis
T25268 2480-2482 IN denotes of
T25269 2483-2492 JJ denotes wild-type
T25270 2493-2496 CC denotes and
T25271 2497-2501 NN denotes LMP1
T25272 2502-2512 JJ denotes transgenic
T25273 2513-2522 NN denotes lymphomas
T25274 2523-2526 IN denotes for
T25275 2527-2530 NN denotes Akt
T25276 2530-2531 -COMMA- denotes ,
T25277 2532-2536 NN denotes NFκB
T25278 2536-2537 -COMMA- denotes ,
T25279 2538-2541 CC denotes and
T25280 2542-2547 NN denotes Stat3
T25281 2548-2557 NN denotes signaling
T25282 2558-2563 IN denotes after
T25283 2564-2573 NN denotes treatment
T25284 2574-2578 IN denotes with
T25285 2579-2580 -LRB- denotes (
T25286 2580-2581 NN denotes A
T25287 2581-2582 -RRB- denotes )
T25288 2583-2585 DT denotes an
T25289 2586-2589 NN denotes Akt
T25290 2590-2599 NN denotes inhibitor
T25291 2599-2600 -COMMA- denotes ,
T25292 2601-2612 NN denotes triciribine
T25293 2612-2613 -COMMA- denotes ,
T25294 2614-2615 -LRB- denotes (
T25295 2615-2616 NN denotes B
T25296 2616-2617 -RRB- denotes )
T25297 2618-2620 DT denotes an
T25298 2621-2625 NN denotes NFκB
T25299 2626-2635 NN denotes inhibitor
T25300 2635-2636 -COMMA- denotes ,
T25301 2637-2647 NN denotes BAY11–7085
T25302 2647-2648 -COMMA- denotes ,
T25303 2649-2652 CC denotes and
T25304 2653-2656 DT denotes the
T25305 2657-2662 NN denotes Stat3
T25306 2663-2673 NN denotes inhibitors
T25307 2674-2675 -LRB- denotes (
T25308 2675-2676 NN denotes C
T25309 2676-2677 -RRB- denotes )
T25310 2678-2690 NN denotes cucurbitacin
T25311 2691-2692 CD denotes I
T25312 2693-2696 CC denotes and
T25313 2697-2698 -LRB- denotes (
T25314 2698-2699 NN denotes D
T25315 2699-2700 -RRB- denotes )
T25316 2701-2706 NN denotes AG490
T25317 2706-2707 -COMMA- denotes ,
T25318 2708-2710 IN denotes at
T25319 2711-2714 DT denotes the
T25320 2715-2724 VB denotes indicated
T25321 2725-2739 NN denotes concentrations
T25322 2741-2747 NN denotes Arrows
T25323 2748-2756 VB denotes indicate
T25324 2757-2760 DT denotes the
T25325 2761-2770 NN denotes positions
T25326 2771-2773 IN denotes of
T25327 2774-2775 NN denotes α
T25328 2776-2779 CC denotes and
T25329 2780-2781 VB denotes β
T25330 2782-2790 NN denotes isoforms
T25331 2791-2793 IN denotes of
T25332 2794-2799 NN denotes Stat3
T25333 2801-2806 NN denotes Actin
T25334 2807-2810 VB denotes was
T25335 2811-2815 VB denotes used
T25336 2816-2818 IN denotes as
T25337 2819-2820 DT denotes a
T25338 2821-2828 NN denotes loading
T25339 2829-2836 NN denotes control
R9394 T12394 T12393 arg2Of viability,of
R9395 T12394 T12395 arg1Of viability,(
R9396 T12396 T12395 arg2Of Figure,(
R9397 T12396 T12397 arg1Of Figure,8
R9398 T12398 T12395 arg3Of ),(
R9399 T12402 T12399 arg1Of inhibitor,A
R9400 T12402 T12400 arg1Of inhibitor,second
R9401 T12402 T12401 arg2Of inhibitor,reported
R9402 T12402 T12403 arg1Of inhibitor,of
R9403 T12402 T12405 arg1Of inhibitor,","
R9404 T12402 T12408 arg1Of inhibitor,had
R9405 T12404 T12403 arg2Of Stat3,of
R9406 T12406 T12405 arg2Of AG490,","
R9407 T12408 T12407 arg1Of had,","
R9408 T12408 T12411 arg1Of had,on
R9409 T12408 T12418 arg1Of had,but
R9410 T12410 T12408 arg2Of effect,had
R9411 T12410 T12409 arg1Of effect,no
R9412 T12412 T12411 arg2Of growth,on
R9413 T12412 T12413 arg1Of growth,(
R9414 T12414 T12413 arg2Of Figure,(
R9415 T12414 T12415 arg1Of Figure,7
R9416 T12416 T12413 arg3Of ),(
R9417 T12418 T12417 arg1Of but,","
R9418 T12419 T12420 arg1Of activation,of
R9419 T12419 T12429 arg1Of activation,were
R9420 T12419 T12432 arg2Of activation,affected
R9421 T12421 T12422 arg1Of Akt,","
R9422 T12422 T12425 arg1Of ",",or
R9423 T12423 T12422 arg2Of Stat3,","
R9424 T12425 T12420 arg2Of or,of
R9425 T12425 T12424 arg1Of or,","
R9426 T12425 T12427 arg1Of or,of
R9427 T12426 T12425 arg2Of levels,or
R9428 T12428 T12427 arg2Of IκBα,of
R9429 T12432 T12418 arg2Of affected,but
R9430 T12432 T12429 arg2Of affected,were
R9431 T12432 T12430 arg1Of affected,also
R9432 T12432 T12431 arg1Of affected,not
R9433 T12432 T12433 arg1Of affected,(
R9434 T12434 T12433 arg2Of Figure,(
R9435 T12434 T12435 arg1Of Figure,8
R9436 T12436 T12433 arg3Of ),(
R9437 T12438 T12437 arg1Of findings,These
R9438 T12438 T12439 arg1Of findings,suggest
R9439 T12441 T12442 arg1Of inhibition,of
R9440 T12441 T12444 arg1Of inhibition,can
R9441 T12441 T12445 arg1Of inhibition,induce
R9442 T12443 T12442 arg2Of Stat3,of
R9443 T12445 T12444 arg2Of induce,can
R9444 T12445 T12448 arg1Of induce,in
R9445 T12445 T12456 arg1Of induce,but
R9446 T12447 T12445 arg2Of death,induce
R9447 T12447 T12446 arg1Of death,cell
R9448 T12451 T12449 arg1Of lymphocytes,LMP1
R9449 T12451 T12450 arg1Of lymphocytes,transgenic
R9450 T12451 T12452 arg1Of lymphocytes,and
R9451 T12452 T12448 arg2Of and,in
R9452 T12454 T12452 arg2Of cells,and
R9453 T12454 T12453 arg1Of cells,lymphoma
R9454 T12456 T12439 arg2Of but,suggest
R9455 T12456 T12440 arg1Of but,that
R9456 T12456 T12455 arg1Of but,","
R9457 T12458 T12457 arg1Of inhibition,Stat3
R9458 T12458 T12460 arg1Of inhibition,has
R9459 T12460 T12456 arg2Of has,but
R9460 T12460 T12459 arg1Of has,also
R9461 T12460 T12464 arg1Of has,on
R9462 T12463 T12460 arg2Of effects,has
R9463 T12463 T12461 arg1Of effects,considerable
R9464 T12463 T12462 arg1Of effects,crossover
R9465 T12465 T12466 arg1Of Akt,and
R9466 T12467 T12466 arg2Of NFκB,and
R9467 T12468 T12464 arg2Of signaling,on
R9468 T12468 T12465 arg1Of signaling,Akt
R9469 T12468 T12467 arg1Of signaling,NFκB
R9470 T12469 T12470 arg1Of LMP1,has
R9471 T12469 T12472 arg1Of LMP1,been
R9472 T12469 T12473 arg2Of LMP1,shown
R9473 T12469 T12475 arg1Of LMP1,activate
R9474 T12473 T12470 arg2Of shown,has
R9475 T12473 T12471 arg1Of shown,also
R9476 T12473 T12472 arg2Of shown,been
R9477 T12473 T12485 arg1Of shown,and
R9478 T12475 T12473 arg3Of activate,shown
R9479 T12475 T12474 arg1Of activate,to
R9480 T12476 T12477 arg1Of JNK,and
R9481 T12478 T12477 arg2Of p38,and
R9482 T12480 T12475 arg2Of pathways,activate
R9483 T12480 T12476 arg1Of pathways,JNK
R9484 T12480 T12478 arg1Of pathways,p38
R9485 T12480 T12479 arg1Of pathways,MAPK
R9486 T12480 T12481 arg1Of pathways,[
R9487 T12482 T12481 arg2Of "13,48",[
R9488 T12483 T12481 arg3Of ],[
R9489 T12485 T12484 arg1Of and,","
R9490 T12488 T12486 arg1Of lymphocytes,LMP1
R9491 T12488 T12487 arg1Of lymphocytes,transgenic
R9492 T12488 T12489 arg1Of lymphocytes,were
R9493 T12488 T12491 arg1Of lymphocytes,susceptible
R9494 T12489 T12485 arg2Of were,and
R9495 T12491 T12489 arg2Of susceptible,were
R9496 T12491 T12490 arg1Of susceptible,mildly
R9497 T12491 T12492 arg1Of susceptible,to
R9498 T12494 T12492 arg2Of inhibition,to
R9499 T12494 T12493 arg1Of inhibition,growth
R9500 T12494 T12495 arg1Of inhibition,by
R9501 T12496 T12497 arg1Of SB202190,","
R9502 T12496 T12504 arg1Of SB202190,but
R9503 T12499 T12497 arg2Of inhibitor,","
R9504 T12499 T12498 arg1Of inhibitor,an
R9505 T12499 T12500 arg1Of inhibitor,of
R9506 T12502 T12500 arg2Of MAPK,of
R9507 T12502 T12501 arg1Of MAPK,p38
R9508 T12504 T12495 arg2Of but,by
R9509 T12504 T12503 arg1Of but,","
R9510 T12504 T12505 arg1Of but,not
R9511 T12506 T12504 arg2Of U0126,but
R9512 T12506 T12507 arg1Of U0126,","
R9513 T12509 T12507 arg2Of inhibitor,","
R9514 T12509 T12508 arg1Of inhibitor,an
R9515 T12509 T12510 arg1Of inhibitor,of
R9516 T12512 T12510 arg2Of activity,of
R9517 T12512 T12511 arg1Of activity,MEK1/2
R9518 T12515 T12516 arg1Of effects,of
R9519 T12515 T12518 arg1Of effects,were
R9520 T12515 T12520 arg1Of effects,apparent
R9521 T12517 T12516 arg2Of SB202190,of
R9522 T12518 T12513 arg1Of were,However
R9523 T12518 T12514 arg1Of were,","
R9524 T12518 T12521 arg1Of were,at
R9525 T12518 T12539 arg1Of were,","
R9526 T12518 T12540 modOf were,suggesting
R9527 T12520 T12518 arg2Of apparent,were
R9528 T12520 T12519 arg1Of apparent,only
R9529 T12523 T12521 arg2Of doses,at
R9530 T12523 T12522 arg1Of doses,high
R9531 T12523 T12524 arg1Of doses,(
R9532 T12523 T12529 arg1Of doses,","
R9533 T12523 T12531 arg1Of doses,higher
R9534 T12526 T12525 arg1Of 10,>
R9535 T12527 T12524 arg2Of μM,(
R9536 T12527 T12526 arg1Of μM,10
R9537 T12528 T12524 arg3Of ),(
R9538 T12531 T12530 arg1Of higher,much
R9539 T12531 T12532 arg1Of higher,than
R9540 T12535 T12532 arg2Of IC50,than
R9541 T12535 T12533 arg1Of IC50,the
R9542 T12535 T12534 arg2Of IC50,reported
R9543 T12535 T12536 arg1Of IC50,of
R9544 T12538 T12536 arg2Of μM,of
R9545 T12538 T12537 arg1Of μM,0.35
R9546 T12543 T12542 arg1Of MAPK,p38
R9547 T12543 T12544 arg1Of MAPK,does
R9548 T12543 T12547 arg1Of MAPK,contribute
R9549 T12547 T12540 arg2Of contribute,suggesting
R9550 T12547 T12541 arg1Of contribute,that
R9551 T12547 T12544 arg2Of contribute,does
R9552 T12547 T12545 arg1Of contribute,not
R9553 T12547 T12546 arg1Of contribute,significantly
R9554 T12547 T12548 arg1Of contribute,to
R9555 T12551 T12548 arg2Of viability,to
R9556 T12551 T12549 arg1Of viability,the
R9557 T12551 T12550 arg2Of viability,enhanced
R9558 T12551 T12552 arg1Of viability,in
R9559 T12555 T12553 arg1Of lymphocytes,LMP1
R9560 T12555 T12554 arg1Of lymphocytes,transgenic
R9561 T12555 T12556 arg1Of lymphocytes,or
R9562 T12556 T12552 arg2Of or,in
R9563 T12558 T12556 arg2Of cells,or
R9564 T12558 T12557 arg1Of cells,lymphoma
R9565 T12558 T12559 arg1Of cells,(
R9566 T12560 T12559 arg2Of Figure,(
R9567 T12560 T12561 arg1Of Figure,7
R9568 T12562 T12559 arg3Of ),(
R9569 T12570 T12565 arg1Of lymphomas,both
R9570 T12570 T12566 arg1Of lymphomas,wild-type
R9571 T12570 T12567 arg1Of lymphomas,and
R9572 T12570 T12568 arg1Of lymphomas,LMP1
R9573 T12570 T12569 arg1Of lymphomas,transgenic
R9574 T12570 T12571 arg1Of lymphomas,were
R9575 T12570 T12573 arg1Of lymphomas,susceptible
R9576 T12570 T12625 arg1Of lymphomas,TOR
R9577 T12570 T12627 arg1Of lymphomas,id not
R9578 T12571 T12593 arg1Of were,","
R9579 T12571 T12594 modOf were,suggesting
R9580 T12571 T12624 arg1Of were,m
R9581 T12573 T12571 arg2Of susceptible,were
R9582 T12573 T12572 arg1Of susceptible,similarly
R9583 T12573 T12574 arg1Of susceptible,to
R9584 T12575 T12576 arg1Of triciribine,","
R9585 T12576 T12579 arg1Of ",",and
R9586 T12577 T12576 arg2Of BAY11–7085,","
R9587 T12579 T12578 arg1Of and,","
R9588 T12579 T12584 arg1Of and,but
R9589 T12582 T12579 arg2Of treatments,and
R9590 T12582 T12580 arg1Of treatments,cucurbitacin
R9591 T12582 T12581 arg1Of treatments,I
R9592 T12584 T12574 arg2Of but,to
R9593 T12584 T12583 arg1Of but,","
R9594 T12584 T12585 arg1Of but,not
R9595 T12586 T12587 arg1Of SB202190,","
R9596 T12587 T12590 arg1Of ",",or
R9597 T12588 T12587 arg2Of AG490,","
R9598 T12590 T12584 arg2Of or,but
R9599 T12590 T12589 arg1Of or,","
R9600 T12592 T12590 arg2Of treatment,or
R9601 T12592 T12591 arg1Of treatment,U0126
R9602 T12596 T12597 arg1Of activation,of
R9603 T12596 T12608 arg1Of activation,are
R9604 T12598 T12599 arg1Of Akt,","
R9605 T12599 T12602 arg1Of ",",and
R9606 T12600 T12599 arg2Of NFκB,","
R9607 T12602 T12601 arg1Of and,","
R9608 T12602 T12604 arg1Of and,but
R9609 T12603 T12602 arg2Of Stat3,and
R9610 T12604 T12597 arg2Of but,of
R9611 T12604 T12605 arg1Of but,not
R9612 T12607 T12604 arg2Of pathways,but
R9613 T12607 T12606 arg1Of pathways,MAPK
R9614 T12608 T12594 arg2Of are,suggesting
R9615 T12608 T12595 arg1Of are,that
R9616 T12609 T12608 arg2Of characteristics,are
R9617 T12609 T12610 arg2Of characteristics,associated
R9618 T12609 T12619 arg1Of characteristics,i
R9619 T12610 T12611 arg1Of associated,with
R9620 T12613 T12612 arg1Of transformation,malignant
R9621 T12613 T12614 arg1Of transformation,(
R9622 T12615 T12614 arg2Of Figure,(
R9623 T12615 T12616 arg1Of Figure,7
R9624 T12617 T12614 arg3Of ),(
R9625 T12618 T12611 arg2Of . rapamyc,with
R9626 T12618 T12613 arg1Of . rapamyc,transformation
R9627 T12621 T12619 arg2Of an inhibi,i
R9628 T12621 T12620 arg1Of an inhibi,"n,"
R9629 T12621 T12622 arg1Of an inhibi,to
R9630 T12623 T12622 arg2Of r of,to
R9631 T12624 T12563 arg1Of m,Interestingly
R9632 T12624 T12564 arg1Of m,","
R9633 T12624 T12638 modOf m,ymphoma ce
R9634 T12627 T12624 arg2Of id not,m
R9635 T12627 T12625 arg2Of id not,TOR
R9636 T12627 T12626 arg1Of id not,", d"
R9637 T12627 T12637 arg1Of id not,l
R9638 T12629 T12627 arg2Of ect the v,id not
R9639 T12629 T12628 arg1Of ect the v,aff
R9640 T12629 T12630 arg1Of ect the v,ia
R9641 T12633 T12632 arg1Of transgenic ,ity of the
R9642 T12633 T12634 arg1Of transgenic ,ly
R9643 T12634 T12630 arg2Of ly,ia
R9644 T12634 T12631 arg1Of ly,bil
R9645 T12636 T12634 arg2Of s or ,ly
R9646 T12636 T12635 arg1Of s or ,mphocyte
R9647 T12640 T12641 arg1Of conf,ir
R9648 T12640 T12643 arg2Of conf,g that m
R9649 T12643 T12638 arg2Of g that m,ymphoma ce
R9650 T12643 T12639 arg1Of g that m,"lls,"
R9651 T12643 T12641 arg2Of g that m,ir
R9652 T12643 T12642 arg1Of g that m,min
R9653 T12646 T12643 arg1Of s not targ,g that m
R9654 T12646 T12644 arg2Of s not targ,TO
R9655 T12646 T12645 arg1Of s not targ,R i
R9656 T12646 T12647 arg1Of s not targ,et
R9657 T12650 T12648 arg1Of vation in L,ed b
R9658 T12650 T12649 arg1Of vation in L,y Akt acti
R9659 T12650 T12651 arg1Of vation in L,MP
R9660 T12651 T12647 arg2Of MP,et
R9661 T12654 T12651 arg2Of hocyt,MP
R9662 T12654 T12652 arg1Of hocyt,1 transge
R9663 T12654 T12653 arg1Of hocyt,nic lymp
R9664 T12654 T12655 arg1Of hocyt,e
R9665 T12656 T12655 arg2Of s or m,e
R9666 T12656 T12657 arg1Of s or m,a
R9667 T12658 T12655 arg3Of l,e
R8882 T11897 T11898 arg1Of LMP1,Promotes
R8883 T11898 T11903 arg1Of Promotes,through
R8884 T11900 T11901 arg1Of Growth,and
R8885 T11901 T11898 arg2Of and,Promotes
R8886 T11901 T11899 arg1Of and,Tumor
R8887 T11902 T11901 arg2Of Survival,and
R8888 T11904 T11903 arg2Of Activation,through
R8889 T11904 T11905 arg1Of Activation,of
R8890 T11906 T11907 arg1Of Akt,","
R8891 T11907 T11910 arg1Of ",",and
R8892 T11908 T11907 arg2Of NFκB,","
R8893 T11910 T11905 arg2Of and,of
R8894 T11910 T11909 arg1Of and,","
R8895 T11912 T11910 arg2Of Pathways,and
R8896 T11912 T11911 arg1Of Pathways,Stat3
R8897 T11914 T11913 arg1Of explore,To
R8898 T11915 T11914 arg2Of which,explore
R8899 T11916 T11915 arg1Of pathways,which
R8900 T11916 T11917 arg1Of pathways,were
R8901 T11916 T11918 arg2Of pathways,required
R8902 T11918 T11917 arg2Of required,were
R8903 T11918 T11919 arg1Of required,for
R8904 T11922 T11923 arg1Of growth,and
R8905 T11923 T11919 arg2Of and,for
R8906 T11923 T11920 arg1Of and,the
R8907 T11923 T11921 arg2Of and,enhanced
R8908 T11923 T11925 arg1Of and,of
R8909 T11924 T11923 arg2Of survival,and
R8910 T11927 T11925 arg2Of lymphomas,of
R8911 T11927 T11926 arg1Of lymphomas,LMP1-induced
R8912 T11929 T11914 arg1Of splenocytes,explore
R8913 T11929 T11930 arg1Of splenocytes,from
R8914 T11929 T11936 arg1Of splenocytes,were
R8915 T11929 T11937 arg2Of splenocytes,cultured
R8916 T11931 T11932 arg1Of wild-type,and
R8917 T11932 T11930 arg2Of and,from
R8918 T11935 T11932 arg2Of mice,and
R8919 T11935 T11933 arg1Of mice,LMP1
R8920 T11935 T11934 arg1Of mice,transgenic
R8921 T11937 T11913 modOf cultured,To
R8922 T11937 T11928 arg1Of cultured,","
R8923 T11937 T11936 arg2Of cultured,were
R8924 T11937 T11938 arg1Of cultured,in
R8925 T11940 T11938 arg2Of presence,in
R8926 T11940 T11939 arg1Of presence,the
R8927 T11940 T11941 arg1Of presence,of
R8928 T11942 T11941 arg2Of inhibitors,of
R8929 T11942 T11943 arg1Of inhibitors,for
R8930 T11942 T11955 arg2Of inhibitors,assayed
R8931 T11943 T11954 arg1Of for,and
R8932 T11944 T11945 arg1Of Akt,","
R8933 T11945 T11947 arg1Of ",",","
R8934 T11946 T11945 arg2Of NFκB,","
R8935 T11947 T11949 arg1Of ",",","
R8936 T11948 T11947 arg2Of Stat3,","
R8937 T11949 T11952 arg1Of ",",or
R8938 T11950 T11949 arg2Of mTOR,","
R8939 T11952 T11943 arg2Of or,for
R8940 T11952 T11951 arg1Of or,","
R8941 T11953 T11952 arg2Of MAPK,or
R8942 T11955 T11954 arg2Of assayed,and
R8943 T11955 T11956 arg1Of assayed,for
R8944 T11957 T11958 arg1Of growth,and
R8945 T11958 T11956 arg2Of and,for
R8946 T11958 T11960 arg1Of and,by
R8947 T11959 T11958 arg2Of survival,and
R8948 T11963 T11960 arg2Of assay,by
R8949 T11963 T11961 arg1Of assay,the
R8950 T11963 T11962 arg1Of assay,MTS
R8951 T11966 T11964 arg2Of shown,As
R8952 T11966 T11965 arg1Of shown,previously
R8953 T11969 T11968 arg1Of lymphocytes,wild-type
R8954 T11969 T11970 arg1Of lymphocytes,were
R8955 T11969 T11972 arg1Of lymphocytes,viable
R8956 T11969 T11976 arg1Of lymphocytes,could
R8957 T11969 T11978 arg1Of lymphocytes,be
R8958 T11969 T11979 arg2Of lymphocytes,tested
R8959 T11970 T11971 arg1Of were,not
R8960 T11970 T11973 arg1Of were,in
R8961 T11970 T11975 arg1Of were,and
R8962 T11972 T11970 arg2Of viable,were
R8963 T11974 T11973 arg2Of culture,in
R8964 T11975 T11964 arg1Of and,As
R8965 T11975 T11967 arg1Of and,","
R8966 T11979 T11975 arg2Of tested,and
R8967 T11979 T11976 arg2Of tested,could
R8968 T11979 T11977 arg1Of tested,not
R8969 T11979 T11978 arg2Of tested,be
R8970 T11979 T11980 arg1Of tested,with
R8971 T11982 T11980 arg2Of inhibitors,with
R8972 T11982 T11981 arg1Of inhibitors,the
R8973 T11987 T11985 arg1Of viability,the
R8974 T11987 T11986 arg2Of viability,enhanced
R8975 T11987 T11988 arg1Of viability,of
R8976 T11987 T11992 arg1Of viability,was
R8977 T11987 T11994 arg2Of viability,blocked
R8978 T11991 T11988 arg2Of lymphocytes,of
R8979 T11991 T11989 arg1Of lymphocytes,LMP1
R8980 T11991 T11990 arg1Of lymphocytes,transgenic
R8981 T11994 T11983 arg1Of blocked,However
R8982 T11994 T11984 arg1Of blocked,","
R8983 T11994 T11992 arg2Of blocked,was
R8984 T11994 T11993 arg1Of blocked,effectively
R8985 T11994 T11997 arg1Of blocked,with
R8986 T11994 T12007 arg1Of blocked,with
R8987 T11994 T12012 arg1Of blocked,by
R8988 T11996 T11994 arg1Of treatment,blocked
R8989 T11996 T11995 arg2Of treatment,by
R8990 T11997 T12005 arg1Of with,and
R8991 T11998 T11999 arg1Of triciribine,","
R8992 T11999 T12001 arg1Of ",",","
R8993 T12000 T11999 arg2Of BAY11–7085,","
R8994 T12001 T11997 arg2Of ",",with
R8995 T12003 T12001 arg2Of I,","
R8996 T12003 T12002 arg1Of I,cucurbitacin
R8997 T12005 T12004 arg1Of and,","
R8998 T12005 T12010 arg1Of and,but
R8999 T12007 T12005 arg2Of with,and
R9000 T12007 T12006 arg1Of with,slightly
R9001 T12008 T12007 arg2Of SB203580,with
R9002 T12010 T12009 arg1Of but,","
R9003 T12012 T12010 arg2Of by,but
R9004 T12012 T12011 arg1Of by,not
R9005 T12013 T12012 arg2Of treatment,by
R9006 T12013 T12014 arg1Of treatment,with
R9007 T12015 T12016 arg1Of rapamycin,","
R9008 T12016 T12019 arg1Of ",",or
R9009 T12017 T12016 arg2Of U0126,","
R9010 T12019 T12014 arg2Of or,with
R9011 T12019 T12018 arg1Of or,","
R9012 T12020 T12019 arg2Of AG490,or
R9013 T12020 T12021 arg1Of AG490,(
R9014 T12022 T12021 arg2Of Figure,(
R9015 T12022 T12023 arg1Of Figure,7
R9016 T12024 T12021 arg3Of ),(
R9017 T12025 T12026 arg1Of Triciribine,inhibits
R9018 T12025 T12035 arg1Of Triciribine,has
R9019 T12025 T12036 arg1Of Triciribine,been
R9020 T12025 T12037 arg2Of Triciribine,shown
R9021 T12025 T12039 arg1Of Triciribine,induce
R9022 T12026 T12031 arg1Of inhibits,and
R9023 T12028 T12026 arg2Of activation,inhibits
R9024 T12028 T12027 arg1Of activation,the
R9025 T12028 T12029 arg1Of activation,of
R9026 T12030 T12029 arg2Of Akt,of
R9027 T12034 T12032 arg2Of μM,at
R9028 T12034 T12033 arg1Of μM,20
R9029 T12037 T12031 arg2Of shown,and
R9030 T12037 T12032 arg1Of shown,at
R9031 T12037 T12035 arg2Of shown,has
R9032 T12037 T12036 arg2Of shown,been
R9033 T12039 T12037 arg3Of induce,shown
R9034 T12039 T12038 arg1Of induce,to
R9035 T12041 T12039 arg2Of arrest,induce
R9036 T12041 T12040 arg1Of arrest,growth
R9037 T12041 T12042 arg1Of arrest,in
R9038 T12041 T12045 arg1Of arrest,with
R9039 T12044 T12042 arg2Of cells,in
R9040 T12044 T12043 arg1Of cells,cancer
R9041 T12048 T12045 arg2Of activity,with
R9042 T12048 T12046 arg1Of activity,aberrant
R9043 T12048 T12047 arg1Of activity,Akt
R9044 T12048 T12049 arg1Of activity,[
R9045 T12050 T12049 arg2Of 46,[
R9046 T12051 T12049 arg3Of ],[
R9047 T12053 T12052 arg1Of effects,The
R9048 T12053 T12054 arg1Of effects,of
R9049 T12053 T12056 arg1Of effects,on
R9050 T12053 T12065 arg1Of effects,were
R9051 T12053 T12066 arg1Of effects,apparent
R9052 T12055 T12054 arg2Of triciribine,of
R9053 T12058 T12056 arg2Of growth,on
R9054 T12058 T12057 arg1Of growth,cell
R9055 T12058 T12059 arg1Of growth,of
R9056 T12062 T12063 arg1Of lymphocytes,and
R9057 T12063 T12059 arg2Of and,of
R9058 T12063 T12060 arg1Of and,the
R9059 T12063 T12061 arg1Of and,transgenic
R9060 T12064 T12063 arg2Of lymphomas,and
R9061 T12065 T12067 arg1Of were,as
R9062 T12065 T12072 arg1Of were,","
R9063 T12065 T12073 modOf were,suggesting
R9064 T12066 T12065 arg2Of apparent,were
R9065 T12067 T12068 arg1Of as,low
R9066 T12067 T12069 arg1Of as,as
R9067 T12071 T12069 arg2Of μM,as
R9068 T12071 T12070 arg1Of μM,1
R9069 T12075 T12076 arg1Of activation,of
R9070 T12075 T12078 arg1Of activation,is
R9071 T12075 T12079 arg2Of activation,required
R9072 T12077 T12076 arg2Of Akt,of
R9073 T12079 T12073 arg2Of required,suggesting
R9074 T12079 T12074 arg1Of required,that
R9075 T12079 T12078 arg2Of required,is
R9076 T12079 T12080 arg1Of required,for
R9077 T12082 T12083 arg1Of survival,and
R9078 T12083 T12080 arg2Of and,for
R9079 T12083 T12081 arg1Of and,the
R9080 T12083 T12085 arg1Of and,of
R9081 T12084 T12083 arg2Of growth,and
R9082 T12088 T12086 arg1Of lymphocytes,LMP1
R9083 T12088 T12087 arg1Of lymphocytes,transgenic
R9084 T12088 T12089 arg1Of lymphocytes,and
R9085 T12089 T12085 arg2Of and,of
R9086 T12091 T12089 arg2Of cells,and
R9087 T12091 T12090 arg1Of cells,lymphoma
R9088 T12091 T12092 arg1Of cells,(
R9089 T12093 T12092 arg2Of Figure,(
R9090 T12093 T12094 arg1Of Figure,7
R9091 T12095 T12092 arg3Of ),(
R9092 T12097 T12096 arg1Of effects,The
R9093 T12097 T12098 arg1Of effects,of
R9094 T12097 T12101 arg1Of effects,were
R9095 T12097 T12102 arg2Of effects,assessed
R9096 T12100 T12098 arg2Of inhibitors,of
R9097 T12100 T12099 arg1Of inhibitors,the
R9098 T12102 T12101 arg2Of assessed,were
R9099 T12102 T12103 arg1Of assessed,by
R9100 T12104 T12103 arg2Of identifying,by
R9101 T12106 T12105 arg2Of Akt,phosphorylated
R9102 T12106 T12107 arg1Of Akt,","
R9103 T12107 T12110 arg1Of ",",and
R9104 T12108 T12107 arg2Of Stat3,","
R9105 T12110 T12104 arg2Of and,identifying
R9106 T12110 T12109 arg1Of and,","
R9107 T12112 T12110 arg2Of levels,and
R9108 T12112 T12111 arg1Of levels,total
R9109 T12112 T12113 arg1Of levels,of
R9110 T12114 T12113 arg2Of IκBα,of
R9111 T12114 T12115 arg1Of IκBα,(
R9112 T12116 T12115 arg2Of Figure,(
R9113 T12116 T12117 arg1Of Figure,8
R9114 T12118 T12115 arg3Of ),(
R9115 T12119 T12120 arg1Of Treatment,with
R9116 T12119 T12123 arg1Of Treatment,blocked
R9117 T12121 T12120 arg2Of triciribine,with
R9118 T12123 T12122 arg1Of blocked,effectively
R9119 T12123 T12128 arg1Of blocked,and
R9120 T12124 T12123 arg2Of phosphorylation,blocked
R9121 T12124 T12125 arg1Of phosphorylation,of
R9122 T12126 T12125 arg2Of Akt,of
R9123 T12128 T12127 arg1Of and,","
R9124 T12130 T12129 arg2Of Akt,phosphorylated
R9125 T12130 T12131 arg1Of Akt,was
R9126 T12130 T12134 arg2Of Akt,detected
R9127 T12133 T12132 arg1Of longer,no
R9128 T12134 T12128 arg2Of detected,and
R9129 T12134 T12131 arg2Of detected,was
R9130 T12134 T12133 arg1Of detected,longer
R9131 T12134 T12135 arg1Of detected,past
R9132 T12137 T12135 arg2Of μM,past
R9133 T12137 T12136 arg1Of μM,5
R9134 T12139 T12140 arg1Of Stat3,and
R9135 T12140 T12138 arg2Of and,Phosphorylated
R9136 T12140 T12142 arg1Of and,were
R9137 T12140 T12144 arg1Of and,present
R9138 T12141 T12140 arg2Of IκBα,and
R9139 T12142 T12143 arg1Of were,still
R9140 T12144 T12142 arg2Of present,were
R9141 T12144 T12145 arg1Of present,at
R9142 T12147 T12145 arg2Of μM,at
R9143 T12147 T12146 arg1Of μM,25
R9144 T12149 T12148 arg1Of findings,These
R9145 T12149 T12150 arg1Of findings,suggest
R9146 T12152 T12154 arg1Of triciribine,targets
R9147 T12154 T12151 arg1Of targets,that
R9148 T12154 T12153 arg1Of targets,specifically
R9149 T12154 T12156 arg1Of targets,and
R9150 T12155 T12154 arg2Of Akt,targets
R9151 T12156 T12150 arg2Of and,suggest
R9152 T12157 T12156 arg2Of that,and
R9153 T12159 T12158 arg1Of activation,Akt
R9154 T12159 T12160 arg1Of activation,is
R9155 T12159 T12161 arg2Of activation,required
R9156 T12161 T12157 arg2Of required,that
R9157 T12161 T12160 arg2Of required,is
R9158 T12161 T12162 arg1Of required,for
R9159 T12165 T12162 arg2Of viability,for
R9160 T12165 T12163 arg1Of viability,the
R9161 T12165 T12164 arg2Of viability,enhanced
R9162 T12165 T12166 arg1Of viability,of
R9163 T12169 T12168 arg1Of lymphocytes,transgenic
R9164 T12169 T12170 arg1Of lymphocytes,and
R9165 T12170 T12166 arg2Of and,of
R9166 T12170 T12167 arg1Of and,the
R9167 T12172 T12170 arg2Of cells,and
R9168 T12172 T12171 arg1Of cells,lymphoma
R9169 T12173 T12174 arg1Of Inhibition,of
R9170 T12173 T12178 arg1Of Inhibition,induces
R9171 T12176 T12174 arg2Of signaling,of
R9172 T12176 T12175 arg1Of signaling,NFκB
R9173 T12178 T12177 arg1Of induces,rapidly
R9174 T12178 T12184 arg1Of induces,[
R9175 T12180 T12178 arg2Of death,induces
R9176 T12180 T12179 arg1Of death,cell
R9177 T12180 T12181 arg1Of death,of
R9178 T12183 T12181 arg2Of lymphocytes,of
R9179 T12183 T12182 arg1Of lymphocytes,EBV-transformed
R9180 T12185 T12184 arg2Of "17,18",[
R9181 T12186 T12184 arg3Of ],[
R9182 T12187 T12188 arg1Of BAY11–7085,","
R9183 T12187 T12197 arg1Of BAY11–7085,decreased
R9184 T12190 T12188 arg2Of inhibitor,","
R9185 T12190 T12189 arg1Of inhibitor,an
R9186 T12190 T12191 arg1Of inhibitor,of
R9187 T12193 T12191 arg2Of signaling,of
R9188 T12193 T12192 arg1Of signaling,NFκB
R9189 T12197 T12194 arg1Of decreased,","
R9190 T12197 T12195 arg1Of decreased,also
R9191 T12197 T12196 arg1Of decreased,greatly
R9192 T12197 T12216 arg1Of decreased,and
R9193 T12199 T12197 arg2Of viability,decreased
R9194 T12199 T12198 arg1Of viability,the
R9195 T12199 T12200 arg1Of viability,of
R9196 T12199 T12208 arg1Of viability,at
R9197 T12204 T12202 arg1Of lymphocytes,LMP1
R9198 T12204 T12203 arg1Of lymphocytes,transgenic
R9199 T12204 T12205 arg1Of lymphocytes,and
R9200 T12205 T12200 arg2Of and,of
R9201 T12205 T12201 arg1Of and,the
R9202 T12207 T12205 arg2Of cells,and
R9203 T12207 T12206 arg1Of cells,lymphoma
R9204 T12213 T12210 arg1Of 1,as
R9205 T12213 T12211 arg1Of 1,low
R9206 T12213 T12212 arg1Of 1,as
R9207 T12214 T12208 arg2Of μM,at
R9208 T12214 T12209 arg1Of μM,doses
R9209 T12214 T12213 arg1Of μM,1
R9210 T12216 T12215 arg1Of and,","
R9211 T12219 T12217 arg2Of μM,at
R9212 T12219 T12218 arg1Of μM,5
R9213 T12221 T12220 arg1Of cells,the
R9214 T12221 T12222 arg1Of cells,were
R9215 T12221 T12224 arg1Of cells,nonviable
R9216 T12222 T12216 arg2Of were,and
R9217 T12222 T12217 arg1Of were,at
R9218 T12224 T12222 arg2Of nonviable,were
R9219 T12224 T12223 arg1Of nonviable,completely
R9220 T12224 T12225 arg1Of nonviable,(
R9221 T12226 T12225 arg2Of Figure,(
R9222 T12226 T12227 arg1Of Figure,7
R9223 T12228 T12225 arg3Of ),(
R9224 T12229 T12230 arg1Of This,is
R9225 T12229 T12232 arg1Of This,within
R9226 T12230 T12231 arg1Of is,well
R9227 T12232 T12230 arg2Of within,is
R9228 T12235 T12232 arg2Of IC50,within
R9229 T12235 T12233 arg1Of IC50,the
R9230 T12235 T12234 arg2Of IC50,reported
R9231 T12235 T12236 arg1Of IC50,of
R9232 T12238 T12236 arg2Of μM,of
R9233 T12238 T12237 arg1Of μM,10
R9234 T12240 T12241 arg1Of Akt,","
R9235 T12241 T12244 arg1Of ",",and
R9236 T12242 T12241 arg2Of Stat3,","
R9237 T12244 T12239 arg2Of and,Phosphorylated
R9238 T12244 T12243 arg1Of and,","
R9239 T12244 T12247 arg1Of and,were
R9240 T12244 T12249 arg1Of and,present
R9241 T12244 T12258 arg1Of and,were
R9242 T12244 T12261 arg2Of and,detected
R9243 T12246 T12244 arg2Of IκBα,and
R9244 T12246 T12245 arg1Of IκBα,total
R9245 T12247 T12248 arg1Of were,still
R9246 T12247 T12256 arg1Of were,and
R9247 T12249 T12247 arg2Of present,were
R9248 T12249 T12251 arg1Of present,to
R9249 T12251 T12250 arg1Of to,up
R9250 T12252 T12251 arg2Of treatment,to
R9251 T12252 T12253 arg1Of treatment,with
R9252 T12255 T12253 arg2Of μM,with
R9253 T12255 T12254 arg1Of μM,15
R9254 T12260 T12259 arg1Of longer,no
R9255 T12261 T12256 arg2Of detected,and
R9256 T12261 T12257 arg1Of detected,then
R9257 T12261 T12258 arg2Of detected,were
R9258 T12261 T12260 arg1Of detected,longer
R9259 T12261 T12262 arg1Of detected,(
R9260 T12263 T12262 arg2Of Figure,(
R9261 T12263 T12264 arg1Of Figure,8
R9262 T12265 T12262 arg3Of ),(
R9263 T12267 T12266 arg1Of finding,This
R9264 T12267 T12268 arg1Of finding,suggests
R9265 T12270 T12271 arg1Of inhibition,of
R9266 T12270 T12273 arg1Of inhibition,can
R9267 T12270 T12274 arg1Of inhibition,induce
R9268 T12272 T12271 arg2Of NFκB,of
R9269 T12274 T12268 arg2Of induce,suggests
R9270 T12274 T12269 arg1Of induce,that
R9271 T12274 T12273 arg2Of induce,can
R9272 T12274 T12284 arg1Of induce,without
R9273 T12274 T12287 arg1Of induce,on
R9274 T12276 T12274 arg2Of death,induce
R9275 T12276 T12275 arg1Of death,cell
R9276 T12276 T12277 arg1Of death,in
R9277 T12280 T12278 arg1Of lymphocytes,LMP1
R9278 T12280 T12279 arg1Of lymphocytes,transgenic
R9279 T12280 T12281 arg1Of lymphocytes,and
R9280 T12281 T12277 arg2Of and,in
R9281 T12283 T12281 arg2Of cells,and
R9282 T12283 T12282 arg1Of cells,lymphoma
R9283 T12286 T12284 arg2Of effects,without
R9284 T12286 T12285 arg1Of effects,significant
R9285 T12288 T12287 arg2Of activation,on
R9286 T12288 T12289 arg1Of activation,of
R9287 T12290 T12291 arg1Of Akt,or
R9288 T12291 T12289 arg2Of or,of
R9289 T12292 T12291 arg2Of Stat3,or
R9290 T12294 T12293 arg1Of I,Cucurbitacin
R9291 T12294 T12295 arg1Of I,inhibits
R9292 T12294 T12300 arg1Of I,suppressing
R9293 T12295 T12299 arg1Of inhibits,by
R9294 T12296 T12295 arg2Of activation,inhibits
R9295 T12296 T12297 arg1Of activation,of
R9296 T12298 T12297 arg2Of Stat3,of
R9297 T12300 T12299 arg2Of suppressing,by
R9298 T12302 T12300 arg2Of activation,suppressing
R9299 T12302 T12301 arg1Of activation,the
R9300 T12302 T12303 arg1Of activation,of
R9301 T12306 T12303 arg2Of JAK2,of
R9302 T12306 T12304 arg1Of JAK2,its
R9303 T12306 T12305 arg1Of JAK2,kinase
R9304 T12307 T12308 arg1Of It,has
R9305 T12307 T12309 arg1Of It,been
R9306 T12307 T12310 arg2Of It,shown
R9307 T12307 T12313 arg1Of It,inhibit
R9308 T12310 T12308 arg2Of shown,has
R9309 T12310 T12309 arg2Of shown,been
R9310 T12313 T12310 arg3Of inhibit,shown
R9311 T12313 T12311 arg1Of inhibit,to
R9312 T12313 T12312 arg1Of inhibit,selectively
R9313 T12315 T12313 arg2Of growth,inhibit
R9314 T12315 T12314 arg1Of growth,the
R9315 T12315 T12316 arg1Of growth,of
R9316 T12317 T12316 arg2Of tumors,of
R9317 T12317 T12318 arg1Of tumors,with
R9318 T12320 T12319 arg1Of activated,constitutively
R9319 T12321 T12318 arg2Of Stat3,with
R9320 T12321 T12320 arg1Of Stat3,activated
R9321 T12321 T12322 arg1Of Stat3,[
R9322 T12323 T12322 arg2Of 47,[
R9323 T12324 T12322 arg3Of ],[
R9324 T12329 T12327 arg1Of lymphocytes,LMP1
R9325 T12329 T12328 arg1Of lymphocytes,transgenic
R9326 T12329 T12330 arg1Of lymphocytes,and
R9327 T12330 T12333 arg1Of and,were
R9328 T12330 T12334 arg1Of and,susceptible
R9329 T12332 T12330 arg2Of cells,and
R9330 T12332 T12331 arg1Of cells,lymphoma
R9331 T12333 T12325 arg1Of were,Similarly
R9332 T12333 T12326 arg1Of were,","
R9333 T12334 T12333 arg2Of susceptible,were
R9334 T12334 T12335 arg1Of susceptible,to
R9335 T12338 T12335 arg2Of treatment,to
R9336 T12338 T12336 arg1Of treatment,cucurbitacin
R9337 T12338 T12337 arg1Of treatment,I
R9338 T12338 T12339 arg1Of treatment,starting
R9339 T12338 T12343 arg1Of treatment,","
R9340 T12339 T12340 arg1Of starting,at
R9341 T12342 T12340 arg2Of μM,at
R9342 T12342 T12341 arg1Of μM,0.1
R9343 T12345 T12343 arg2Of dose,","
R9344 T12345 T12344 arg1Of dose,a
R9345 T12345 T12346 arg1Of dose,that
R9346 T12345 T12347 arg1Of dose,corresponds
R9347 T12347 T12348 arg1Of corresponds,closely
R9348 T12347 T12349 arg1Of corresponds,to
R9349 T12352 T12349 arg2Of IC50,to
R9350 T12352 T12350 arg1Of IC50,the
R9351 T12352 T12351 arg2Of IC50,reported
R9352 T12352 T12353 arg1Of IC50,of
R9353 T12355 T12353 arg2Of nM,of
R9354 T12355 T12354 arg1Of nM,500
R9355 T12355 T12356 arg1Of nM,(
R9356 T12355 T12360 arg1Of nM,[
R9357 T12357 T12356 arg2Of Figure,(
R9358 T12357 T12358 arg1Of Figure,7
R9359 T12359 T12356 arg3Of ),(
R9360 T12361 T12360 arg2Of 47,[
R9361 T12362 T12360 arg3Of ],[
R9362 T12364 T12365 arg1Of Akt,","
R9363 T12365 T12368 arg1Of ",",and
R9364 T12366 T12365 arg2Of Stat3,","
R9365 T12368 T12363 arg2Of and,Phosphorylated
R9366 T12368 T12367 arg1Of and,","
R9367 T12368 T12371 arg1Of and,were
R9368 T12368 T12373 arg1Of and,detectable
R9369 T12370 T12368 arg2Of IκBα,and
R9370 T12370 T12369 arg1Of IκBα,total
R9371 T12371 T12372 arg1Of were,not
R9372 T12371 T12374 arg1Of were,past
R9373 T12371 T12377 arg1Of were,and
R9374 T12373 T12371 arg2Of detectable,were
R9375 T12376 T12374 arg2Of μM,past
R9376 T12376 T12375 arg1Of μM,1
R9377 T12380 T12378 arg2Of doses,at
R9378 T12380 T12379 arg1Of doses,higher
R9379 T12383 T12381 arg1Of levels,all
R9380 T12383 T12382 arg1Of levels,protein
R9381 T12383 T12384 arg1Of levels,were
R9382 T12383 T12386 arg2Of levels,decreased
R9383 T12386 T12377 arg2Of decreased,and
R9384 T12386 T12378 arg1Of decreased,at
R9385 T12386 T12384 arg2Of decreased,were
R9386 T12386 T12385 arg1Of decreased,greatly
R9387 T12386 T12387 arg1Of decreased,","
R9388 T12386 T12388 arg1Of decreased,indicative
R9389 T12388 T12389 arg1Of indicative,of
R9390 T12392 T12389 arg2Of loss,of
R9391 T12392 T12390 arg1Of loss,the
R9392 T12392 T12391 arg1Of loss,total
R9393 T12392 T12393 arg1Of loss,of
R19229 T24804 T24805 arg1Of Akt,","
R19230 T24805 T24808 arg1Of ",",and
R19231 T24806 T24805 arg2Of NFκB,","
R19232 T24808 T24807 arg1Of and,","
R19233 T24808 T24811 arg1Of and,Are
R19234 T24808 T24812 arg2Of and,Required
R19235 T24810 T24808 arg2Of Signaling,and
R19236 T24810 T24809 arg1Of Signaling,Stat3
R19237 T24812 T24811 arg2Of Required,Are
R19238 T24812 T24813 arg1Of Required,for
R19239 T24815 T24816 arg1Of Growth,and
R19240 T24816 T24813 arg2Of and,for
R19241 T24816 T24814 arg1Of and,the
R19242 T24816 T24818 arg1Of and,of
R19243 T24817 T24816 arg2Of Survival,and
R19244 T24820 T24818 arg2Of Cells,of
R19245 T24820 T24819 arg1Of Cells,Lymphoma
R19246 T24822 T24821 arg1Of assay,MTS
R19247 T24822 T24823 arg1Of assay,of
R19248 T24822 T24832 arg1Of assay,or
R19249 T24824 T24823 arg2Of splenocytes,of
R19250 T24824 T24825 arg1Of splenocytes,from
R19251 T24827 T24828 arg1Of A,and
R19252 T24828 T24826 arg2Of and,(
R19253 T24829 T24828 arg2Of B,and
R19254 T24830 T24826 arg3Of ),(
R19255 T24831 T24825 arg2Of WT,from
R19256 T24831 T24826 arg1Of WT,(
R19257 T24834 T24835 arg1Of C,and
R19258 T24835 T24833 arg2Of and,(
R19259 T24836 T24835 arg2Of D,and
R19260 T24837 T24833 arg3Of ),(
R19261 T24840 T24833 arg1Of lymphomas,(
R19262 T24840 T24838 arg1Of lymphomas,LMP1
R19263 T24840 T24839 arg1Of lymphomas,transgenic
R19264 T24840 T24841 arg1Of lymphomas,and
R19265 T24841 T24832 arg2Of and,or
R19266 T24843 T24844 arg1Of E,and
R19267 T24844 T24842 arg2Of and,(
R19268 T24845 T24844 arg2Of F,and
R19269 T24846 T24842 arg3Of ),(
R19270 T24849 T24841 arg2Of lymphoctyes,and
R19271 T24849 T24842 arg1Of lymphoctyes,(
R19272 T24849 T24847 arg1Of lymphoctyes,LMP1
R19273 T24849 T24848 arg1Of lymphoctyes,transgenic
R19274 T24850 T24851 arg1Of Splenocytes,were
R19275 T24850 T24852 arg2Of Splenocytes,cultured
R19276 T24852 T24851 arg2Of cultured,were
R19277 T24852 T24853 arg1Of cultured,with
R19278 T24852 T24855 arg1Of cultured,without
R19279 T24853 T24854 arg1Of with,or
R19280 T24855 T24854 arg2Of without,or
R19281 T24856 T24853 arg2Of inhibitors,with
R19282 T24856 T24855 arg2Of inhibitors,without
R19283 T24856 T24857 arg1Of inhibitors,of
R19284 T24858 T24859 arg1Of NFκB,(
R19285 T24858 T24862 arg1Of NFκB,","
R19286 T24860 T24859 arg2Of BAY11,(
R19287 T24861 T24859 arg3Of ),(
R19288 T24862 T24867 arg1Of ",",","
R19289 T24863 T24862 arg2Of mTOR,","
R19290 T24863 T24864 arg1Of mTOR,(
R19291 T24865 T24864 arg2Of rapamycin,(
R19292 T24866 T24864 arg3Of ),(
R19293 T24867 T24872 arg1Of ",",","
R19294 T24868 T24867 arg2Of Akt,","
R19295 T24868 T24869 arg1Of Akt,(
R19296 T24870 T24869 arg2Of triciribine,(
R19297 T24871 T24869 arg3Of ),(
R19298 T24872 T24857 arg2Of ",",of
R19299 T24873 T24874 arg1Of MEK1/2,(
R19300 T24873 T24877 arg1Of MEK1/2,","
R19301 T24875 T24874 arg2Of U0126,(
R19302 T24876 T24874 arg3Of ),(
R19303 T24877 T24883 arg1Of ",",or
R19304 T24878 T24877 arg2Of p38,","
R19305 T24878 T24879 arg1Of p38,(
R19306 T24880 T24879 arg2Of SB202190,(
R19307 T24881 T24879 arg3Of ),(
R19308 T24883 T24872 arg2Of or,","
R19309 T24883 T24882 arg1Of or,","
R19310 T24884 T24883 arg2Of Stat3,or
R19311 T24884 T24885 arg1Of Stat3,(
R19312 T24884 T24891 arg1Of Stat3,at
R19313 T24886 T24887 arg1Of cucurbitacin,I
R19314 T24886 T24888 arg1Of cucurbitacin,and
R19315 T24888 T24885 arg2Of and,(
R19316 T24889 T24888 arg2Of AG490,and
R19317 T24890 T24885 arg3Of ),(
R19318 T24894 T24891 arg2Of concentrations,at
R19319 T24894 T24892 arg1Of concentrations,the
R19320 T24894 T24893 arg2Of concentrations,indicated
R19321 T24896 T24895 arg1Of results,The
R19322 T24896 T24897 arg1Of results,are
R19323 T24901 T24897 arg2Of SEM,are
R19324 T24901 T24898 arg1Of SEM,the
R19325 T24901 T24899 arg1Of SEM,mean
R19326 T24901 T24900 arg1Of SEM,±
R19327 T24901 T24902 arg1Of SEM,of
R19328 T24904 T24902 arg2Of samples,of
R19329 T24904 T24903 arg1Of samples,triplicate
R19330 T24906 T24905 modOf are,Shown
R19331 T24908 T24905 arg2Of results,Shown
R19332 T24908 T24906 arg1Of results,are
R19333 T24908 T24907 arg1Of results,the
R19334 T24908 T24909 arg1Of results,for
R19335 T24911 T24912 arg1Of A,and
R19336 T24912 T24910 arg2Of and,(
R19337 T24913 T24912 arg2Of B,and
R19338 T24914 T24910 arg3Of ),(
R19339 T24916 T24910 arg1Of lymphoma,(
R19340 T24916 T24915 arg1Of lymphoma,WT
R19341 T24916 T24917 arg1Of lymphoma,1
R19342 T24916 T24918 arg1Of lymphoma,","
R19343 T24918 T24929 arg1Of ",",and
R19344 T24920 T24921 arg1Of C,and
R19345 T24921 T24919 arg2Of and,(
R19346 T24922 T24921 arg2Of D,and
R19347 T24923 T24919 arg3Of ),(
R19348 T24926 T24918 arg2Of lymphoma,","
R19349 T24926 T24919 arg1Of lymphoma,(
R19350 T24926 T24924 arg1Of lymphoma,LMP1
R19351 T24926 T24925 arg1Of lymphoma,transgenic
R19352 T24926 T24927 arg1Of lymphoma,2
R19353 T24929 T24909 arg2Of and,for
R19354 T24929 T24928 arg1Of and,","
R19355 T24929 T24935 arg1Of and,one
R19356 T24931 T24932 arg1Of E,and
R19357 T24932 T24929 arg2Of and,and
R19358 T24932 T24930 arg2Of and,(
R19359 T24933 T24932 arg2Of F,and
R19360 T24934 T24930 arg3Of ),(
R19361 T24935 T24936 arg1Of one,out
R19362 T24941 T24936 arg2Of mice,out
R19363 T24941 T24937 arg1Of mice,of
R19364 T24941 T24938 arg1Of mice,two
R19365 T24941 T24939 arg1Of mice,LMP1
R19366 T24941 T24940 arg1Of mice,transgenic
R19367 T24941 T24942 arg2Of mice,analyzed
R19368 T24944 T24943 arg1Of analysis,This
R19369 T24944 T24945 arg1Of analysis,was
R19370 T24944 T24946 arg2Of analysis,repeated
R19371 T24946 T24945 arg2Of repeated,was
R19372 T24946 T24947 arg1Of repeated,with
R19373 T24954 T24947 arg2Of results,with
R19374 T24954 T24948 arg1Of results,LMP1
R19375 T24954 T24949 arg1Of results,transgenic
R19376 T24954 T24950 arg1Of results,lymphoma
R19377 T24954 T24951 arg1Of results,4
R19378 T24954 T24952 arg1Of results,yielding
R19379 T24954 T24953 arg1Of results,similar
R19563 T25244 T25245 arg1Of Analysis,of
R19564 T25244 T25253 arg1Of Analysis,in
R19565 T25246 T25247 arg1Of Akt,","
R19566 T25247 T25250 arg1Of ",",and
R19567 T25248 T25247 arg2Of NFκB,","
R19568 T25250 T25245 arg2Of and,of
R19569 T25250 T25249 arg1Of and,","
R19570 T25252 T25250 arg2Of Pathways,and
R19571 T25252 T25251 arg1Of Pathways,Stat3
R19572 T25254 T25253 arg2Of Contribution,in
R19573 T25254 T25255 arg1Of Contribution,to
R19574 T25257 T25258 arg1Of Growth,and
R19575 T25258 T25255 arg2Of and,to
R19576 T25258 T25256 arg1Of and,the
R19577 T25258 T25260 arg1Of and,of
R19578 T25259 T25258 arg2Of Survival,and
R19579 T25262 T25260 arg2Of Cells,of
R19580 T25262 T25261 arg1Of Cells,Lymphoma
R19581 T25264 T25263 arg2Of A–D,(
R19582 T25265 T25263 arg3Of ),(
R19583 T25267 T25263 arg1Of analysis,(
R19584 T25267 T25266 arg1Of analysis,Immunoblot
R19585 T25267 T25268 arg1Of analysis,of
R19586 T25267 T25274 arg1Of analysis,for
R19587 T25267 T25282 arg1Of analysis,after
R19588 T25267 T25312 arg1Of analysis,and
R19589 T25269 T25270 arg1Of wild-type,and
R19590 T25270 T25268 arg2Of and,of
R19591 T25273 T25270 arg2Of lymphomas,and
R19592 T25273 T25271 arg1Of lymphomas,LMP1
R19593 T25273 T25272 arg1Of lymphomas,transgenic
R19594 T25275 T25276 arg1Of Akt,","
R19595 T25276 T25279 arg1Of ",",and
R19596 T25277 T25276 arg2Of NFκB,","
R19597 T25279 T25274 arg2Of and,for
R19598 T25279 T25278 arg1Of and,","
R19599 T25281 T25279 arg2Of signaling,and
R19600 T25281 T25280 arg1Of signaling,Stat3
R19601 T25283 T25284 arg1Of treatment,with
R19602 T25283 T25293 arg1Of treatment,","
R19603 T25284 T25285 arg1Of with,(
R19604 T25286 T25285 arg2Of A,(
R19605 T25287 T25285 arg3Of ),(
R19606 T25290 T25284 arg2Of inhibitor,with
R19607 T25290 T25288 arg1Of inhibitor,an
R19608 T25290 T25289 arg1Of inhibitor,Akt
R19609 T25290 T25291 arg1Of inhibitor,","
R19610 T25292 T25291 arg2Of triciribine,","
R19611 T25293 T25300 arg1Of ",",","
R19612 T25293 T25303 arg1Of ",",and
R19613 T25295 T25294 arg2Of B,(
R19614 T25295 T25298 arg1Of B,NFκB
R19615 T25296 T25294 arg3Of ),(
R19616 T25298 T25297 arg1Of NFκB,an
R19617 T25299 T25293 arg2Of inhibitor,","
R19618 T25299 T25294 arg1Of inhibitor,(
R19619 T25301 T25300 arg2Of BAY11–7085,","
R19620 T25303 T25282 arg2Of and,after
R19621 T25303 T25302 arg1Of and,","
R19622 T25306 T25305 arg1Of inhibitors,Stat3
R19623 T25306 T25307 arg1Of inhibitors,(
R19624 T25308 T25307 arg2Of C,(
R19625 T25309 T25307 arg3Of ),(
R19626 T25310 T25303 arg2Of cucurbitacin,and
R19627 T25310 T25304 arg1Of cucurbitacin,the
R19628 T25310 T25306 arg1Of cucurbitacin,inhibitors
R19629 T25310 T25311 arg1Of cucurbitacin,I
R19630 T25312 T25317 arg1Of and,","
R19631 T25312 T25318 arg1Of and,at
R19632 T25314 T25313 arg2Of D,(
R19633 T25315 T25313 arg3Of ),(
R19634 T25316 T25312 arg2Of AG490,and
R19635 T25316 T25313 arg1Of AG490,(
R19636 T25321 T25318 arg2Of concentrations,at
R19637 T25321 T25319 arg1Of concentrations,the
R19638 T25321 T25320 arg2Of concentrations,indicated
R19639 T25322 T25323 arg1Of Arrows,indicate
R19640 T25322 T25329 arg1Of Arrows,β
R19641 T25323 T25328 arg1Of indicate,and
R19642 T25325 T25323 arg2Of positions,indicate
R19643 T25325 T25324 arg1Of positions,the
R19644 T25325 T25326 arg1Of positions,of
R19645 T25327 T25326 arg2Of α,of
R19646 T25329 T25328 arg2Of β,and
R19647 T25330 T25329 arg2Of isoforms,β
R19648 T25330 T25331 arg1Of isoforms,of
R19649 T25332 T25331 arg2Of Stat3,of
R19650 T25333 T25334 arg1Of Actin,was
R19651 T25333 T25335 arg2Of Actin,used
R19652 T25335 T25334 arg2Of used,was
R19653 T25335 T25336 arg1Of used,as
R19654 T25339 T25336 arg2Of control,as
R19655 T25339 T25337 arg1Of control,a
R19656 T25339 T25338 arg1Of control,loading

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T12659 4007-4018 Anaphor denotes all protein
T12660 3930-3933 Antecedent denotes Akt
T12661 3935-3940 Antecedent denotes Stat3
T12662 3952-3956 Antecedent denotes IκBα
R9668 T12659 T12660 boundBy all protein,Akt
R9669 T12659 T12661 boundBy all protein,Stat3
R9670 T12659 T12662 boundBy all protein,IκBα

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T12763 0-4 CD denotes LMP1
T12764 5-13 NNP denotes Promotes
T12765 14-19 NNP denotes Tumor
T12766 20-26 NNP denotes Growth
T12767 27-30 CC denotes and
T12768 31-39 NNP denotes Survival
T12769 40-47 IN denotes through
T12770 48-58 NNP denotes Activation
T12771 59-61 IN denotes of
T12772 62-65 NNP denotes Akt
T12773 65-66 , denotes ,
T12774 67-71 NNP denotes NFκB
T12775 71-72 , denotes ,
T12776 73-76 CC denotes and
T12777 77-82 NNP denotes Stat3
T12778 83-91 NNPS denotes Pathways
T12779 92-94 TO denotes To
T12780 95-102 VB denotes explore
T12781 103-108 WDT denotes which
T12782 109-117 NNS denotes pathways
T12783 118-122 VBD denotes were
T12784 123-131 VBN denotes required
T12785 132-135 IN denotes for
T12786 136-139 DT denotes the
T12787 140-148 JJ denotes enhanced
T12788 149-155 NN denotes growth
T12789 156-159 CC denotes and
T12790 160-168 NN denotes survival
T12791 169-171 IN denotes of
T12792 172-184 JJ denotes LMP1-induced
T12793 185-194 NNS denotes lymphomas
T12794 194-195 , denotes ,
T12795 196-207 NNS denotes splenocytes
T12796 208-212 IN denotes from
T12797 213-222 JJ denotes wild-type
T12798 223-226 CC denotes and
T12799 227-231 JJ denotes LMP1
T12800 232-242 JJ denotes transgenic
T12801 243-247 NNS denotes mice
T12802 248-252 VBD denotes were
T12803 253-261 VBN denotes cultured
T12804 262-264 IN denotes in
T12805 265-268 DT denotes the
T12806 269-277 NN denotes presence
T12807 278-280 IN denotes of
T12808 281-291 NNS denotes inhibitors
T12809 292-295 IN denotes for
T12810 296-299 NNP denotes Akt
T12811 299-300 , denotes ,
T12812 301-305 NNP denotes NFκB
T12813 305-306 , denotes ,
T12814 307-312 NNP denotes Stat3
T12815 312-313 , denotes ,
T12816 314-318 NNP denotes mTOR
T12817 318-319 , denotes ,
T12818 320-322 CC denotes or
T12819 323-327 NNP denotes MAPK
T12820 328-331 CC denotes and
T12821 332-339 VBN denotes assayed
T12822 340-343 IN denotes for
T12823 344-350 NN denotes growth
T12824 351-354 CC denotes and
T12825 355-363 NN denotes survival
T12826 364-366 IN denotes by
T12827 367-370 DT denotes the
T12828 371-374 NNP denotes MTS
T12829 375-380 NN denotes assay
T12830 380-381 . denotes .
T12831 382-384 IN denotes As
T12832 385-395 RB denotes previously
T12833 396-401 VBN denotes shown
T12834 401-402 , denotes ,
T12835 403-412 JJ denotes wild-type
T12836 413-424 NNS denotes lymphocytes
T12837 425-429 VBD denotes were
T12838 430-433 RB denotes not
T12839 434-440 JJ denotes viable
T12840 441-443 IN denotes in
T12841 444-451 NN denotes culture
T12842 452-455 CC denotes and
T12843 456-461 MD denotes could
T12844 462-465 RB denotes not
T12845 466-468 VB denotes be
T12846 469-475 VBN denotes tested
T12847 476-480 IN denotes with
T12848 481-484 DT denotes the
T12849 485-495 NNS denotes inhibitors
T12850 495-496 . denotes .
T12851 497-504 RB denotes However
T12852 504-505 , denotes ,
T12853 506-509 DT denotes the
T12854 510-518 JJ denotes enhanced
T12855 519-528 NN denotes viability
T12856 529-531 IN denotes of
T12857 532-536 CD denotes LMP1
T12858 537-547 JJ denotes transgenic
T12859 548-559 NNS denotes lymphocytes
T12860 560-563 VBD denotes was
T12861 564-575 RB denotes effectively
T12862 576-583 VBN denotes blocked
T12863 584-586 IN denotes by
T12864 587-596 NN denotes treatment
T12865 597-601 IN denotes with
T12866 602-613 NN denotes triciribine
T12867 613-614 , denotes ,
T12868 615-620 NNP denotes BAY11
T12869 621-625 CD denotes 7085
T12870 625-626 , denotes ,
T12871 627-639 NN denotes cucurbitacin
T12872 640-641 PRP denotes I
T12873 641-642 , denotes ,
T12874 643-646 CC denotes and
T12875 647-655 RB denotes slightly
T12876 656-660 IN denotes with
T12877 661-669 CD denotes SB203580
T12878 669-670 , denotes ,
T12879 671-674 CC denotes but
T12880 675-678 RB denotes not
T12881 679-681 IN denotes by
T12882 682-691 NN denotes treatment
T12883 692-696 IN denotes with
T12884 697-706 NN denotes rapamycin
T12885 706-707 , denotes ,
T12886 708-713 NNP denotes U0126
T12887 713-714 , denotes ,
T12888 715-717 CC denotes or
T12889 718-723 NNP denotes AG490
T12890 724-725 -LRB- denotes (
T12891 725-731 NNP denotes Figure
T12892 732-733 CD denotes 7
T12893 733-734 -RRB- denotes )
T12894 734-735 . denotes .
T12895 736-747 NNP denotes Triciribine
T12896 748-756 VBZ denotes inhibits
T12897 757-760 DT denotes the
T12898 761-771 NN denotes activation
T12899 772-774 IN denotes of
T12900 775-778 NNP denotes Akt
T12901 779-782 CC denotes and
T12902 783-785 IN denotes at
T12903 786-788 CD denotes 20
T12904 789-791 NN denotes μM
T12905 792-795 VBZ denotes has
T12906 796-800 VBN denotes been
T12907 801-806 VBN denotes shown
T12908 807-809 TO denotes to
T12909 810-816 VB denotes induce
T12910 817-823 NN denotes growth
T12911 824-830 NN denotes arrest
T12912 831-833 IN denotes in
T12913 834-840 NN denotes cancer
T12914 841-846 NNS denotes cells
T12915 847-851 IN denotes with
T12916 852-860 JJ denotes aberrant
T12917 861-864 NNP denotes Akt
T12918 865-873 NN denotes activity
T12919 874-875 NNP denotes [
T12920 875-877 CD denotes 46
T12921 877-878 NNP denotes ]
T12922 878-879 . denotes .
T12923 880-883 DT denotes The
T12924 884-891 NNS denotes effects
T12925 892-894 IN denotes of
T12926 895-906 NN denotes triciribine
T12927 907-909 IN denotes on
T12928 910-914 NN denotes cell
T12929 915-921 NN denotes growth
T12930 922-924 IN denotes of
T12931 925-928 DT denotes the
T12932 929-939 JJ denotes transgenic
T12933 940-951 NNS denotes lymphocytes
T12934 952-955 CC denotes and
T12935 956-965 NNS denotes lymphomas
T12936 966-970 VBD denotes were
T12937 971-979 JJ denotes apparent
T12938 980-982 RB denotes as
T12939 983-986 JJ denotes low
T12940 987-989 IN denotes as
T12941 990-991 CD denotes 1
T12942 992-994 NNP denotes μM
T12943 994-995 , denotes ,
T12944 996-1006 VBG denotes suggesting
T12945 1007-1011 IN denotes that
T12946 1012-1022 NN denotes activation
T12947 1023-1025 IN denotes of
T12948 1026-1029 NNP denotes Akt
T12949 1030-1032 VBZ denotes is
T12950 1033-1041 VBN denotes required
T12951 1042-1045 IN denotes for
T12952 1046-1049 DT denotes the
T12953 1050-1058 NN denotes survival
T12954 1059-1062 CC denotes and
T12955 1063-1069 NN denotes growth
T12956 1070-1072 IN denotes of
T12957 1073-1077 CD denotes LMP1
T12958 1078-1088 JJ denotes transgenic
T12959 1089-1100 NNS denotes lymphocytes
T12960 1101-1104 CC denotes and
T12961 1105-1113 NN denotes lymphoma
T12962 1114-1119 NNS denotes cells
T12963 1120-1121 -LRB- denotes (
T12964 1121-1127 NN denotes Figure
T12965 1128-1129 CD denotes 7
T12966 1129-1130 -RRB- denotes )
T12967 1130-1131 . denotes .
T12968 1132-1135 DT denotes The
T12969 1136-1143 NNS denotes effects
T12970 1144-1146 IN denotes of
T12971 1147-1150 DT denotes the
T12972 1151-1161 NNS denotes inhibitors
T12973 1162-1166 VBD denotes were
T12974 1167-1175 VBN denotes assessed
T12975 1176-1178 IN denotes by
T12976 1179-1190 VBG denotes identifying
T12977 1191-1205 VBN denotes phosphorylated
T12978 1206-1209 NNP denotes Akt
T12979 1209-1210 , denotes ,
T12980 1211-1216 NNP denotes Stat3
T12981 1216-1217 , denotes ,
T12982 1218-1221 CC denotes and
T12983 1222-1227 JJ denotes total
T12984 1228-1234 NNS denotes levels
T12985 1235-1237 IN denotes of
T12986 1238-1242 NNP denotes IκBα
T12987 1243-1244 -LRB- denotes (
T12988 1244-1250 NNP denotes Figure
T12989 1251-1252 CD denotes 8
T12990 1252-1253 -RRB- denotes )
T12991 1253-1254 . denotes .
T12992 1255-1264 NNP denotes Treatment
T12993 1265-1269 IN denotes with
T12994 1270-1281 JJ denotes triciribine
T12995 1282-1293 RB denotes effectively
T12996 1294-1301 VBN denotes blocked
T12997 1302-1317 NN denotes phosphorylation
T12998 1318-1320 IN denotes of
T12999 1321-1324 NNP denotes Akt
T13000 1324-1325 , denotes ,
T13001 1326-1329 CC denotes and
T13002 1330-1344 VBD denotes phosphorylated
T13003 1345-1348 NNP denotes Akt
T13004 1349-1352 VBD denotes was
T13005 1353-1355 RB denotes no
T13006 1356-1362 RB denotes longer
T13007 1363-1371 VBN denotes detected
T13008 1372-1376 JJ denotes past
T13009 1377-1378 CD denotes 5
T13010 1379-1381 NN denotes μM
T13011 1381-1382 . denotes .
T13012 1383-1397 NNP denotes Phosphorylated
T13013 1398-1403 NNP denotes Stat3
T13014 1404-1407 CC denotes and
T13015 1408-1412 NNP denotes IκBα
T13016 1413-1417 VBD denotes were
T13017 1418-1423 RB denotes still
T13018 1424-1431 JJ denotes present
T13019 1432-1434 IN denotes at
T13020 1435-1437 CD denotes 25
T13021 1438-1440 NN denotes μM
T13022 1440-1441 . denotes .
T13023 1442-1447 DT denotes These
T13024 1448-1456 NNS denotes findings
T13025 1457-1464 VBP denotes suggest
T13026 1465-1469 IN denotes that
T13027 1470-1481 JJ denotes triciribine
T13028 1482-1494 RB denotes specifically
T13029 1495-1502 VBZ denotes targets
T13030 1503-1506 NNP denotes Akt
T13031 1507-1510 CC denotes and
T13032 1511-1515 IN denotes that
T13033 1516-1519 NNP denotes Akt
T13034 1520-1530 NN denotes activation
T13035 1531-1533 VBZ denotes is
T13036 1534-1542 VBN denotes required
T13037 1543-1546 IN denotes for
T13038 1547-1550 DT denotes the
T13039 1551-1559 JJ denotes enhanced
T13040 1560-1569 NN denotes viability
T13041 1570-1572 IN denotes of
T13042 1573-1576 DT denotes the
T13043 1577-1587 JJ denotes transgenic
T13044 1588-1599 NNS denotes lymphocytes
T13045 1600-1603 CC denotes and
T13046 1604-1612 NN denotes lymphoma
T13047 1613-1618 NNS denotes cells
T13048 1618-1619 . denotes .
T13049 2840-2850 NNP denotes Inhibition
T13050 2851-2853 IN denotes of
T13051 2854-2858 NNP denotes NFκB
T13052 2859-2868 VBG denotes signaling
T13053 2869-2876 RB denotes rapidly
T13054 2877-2884 VBZ denotes induces
T13055 2885-2889 NN denotes cell
T13056 2890-2895 NN denotes death
T13057 2896-2898 IN denotes of
T13058 2899-2914 JJ denotes EBV-transformed
T13059 2915-2926 NNS denotes lymphocytes
T13060 2927-2928 NNP denotes [
T13061 2928-2933 CD denotes 17,18
T13062 2933-2934 NNP denotes ]
T13063 2934-2935 . denotes .
T13064 2936-2941 CD denotes BAY11
T13065 2942-2946 CD denotes 7085
T13066 2946-2947 , denotes ,
T13067 2948-2950 DT denotes an
T13068 2951-2960 NN denotes inhibitor
T13069 2961-2963 IN denotes of
T13070 2964-2968 NNP denotes NFκB
T13071 2969-2978 VBG denotes signaling
T13072 2978-2979 , denotes ,
T13073 2980-2984 RB denotes also
T13074 2985-2992 RB denotes greatly
T13075 2993-3002 VBD denotes decreased
T13076 3003-3006 DT denotes the
T13077 3007-3016 NN denotes viability
T13078 3017-3019 IN denotes of
T13079 3020-3023 DT denotes the
T13080 3024-3028 NNP denotes LMP1
T13081 3029-3039 NN denotes transgenic
T13082 3040-3051 NNS denotes lymphocytes
T13083 3052-3055 CC denotes and
T13084 3056-3064 NN denotes lymphoma
T13085 3065-3070 NNS denotes cells
T13086 3071-3073 IN denotes at
T13087 3074-3079 NNS denotes doses
T13088 3080-3082 RB denotes as
T13089 3083-3086 JJ denotes low
T13090 3087-3089 IN denotes as
T13091 3090-3091 CD denotes 1
T13092 3092-3094 NNP denotes μM
T13093 3094-3095 , denotes ,
T13094 3096-3099 CC denotes and
T13095 3100-3102 IN denotes at
T13096 3103-3104 CD denotes 5
T13097 3105-3107 NNP denotes μM
T13098 3108-3111 DT denotes the
T13099 3112-3117 NNS denotes cells
T13100 3118-3122 VBD denotes were
T13101 3123-3133 RB denotes completely
T13102 3134-3143 JJ denotes nonviable
T13103 3144-3145 -LRB- denotes (
T13104 3145-3151 NN denotes Figure
T13105 3152-3153 CD denotes 7
T13106 3153-3154 -RRB- denotes )
T13107 3154-3155 . denotes .
T13108 3156-3160 DT denotes This
T13109 3161-3163 VBZ denotes is
T13110 3164-3168 RB denotes well
T13111 3169-3175 IN denotes within
T13112 3176-3179 DT denotes the
T13113 3180-3188 VBN denotes reported
T13114 3189-3193 NNP denotes IC50
T13115 3194-3196 IN denotes of
T13116 3197-3199 CD denotes 10
T13117 3200-3202 NN denotes μM
T13118 3202-3203 . denotes .
T13119 3204-3218 NNP denotes Phosphorylated
T13120 3219-3222 NNP denotes Akt
T13121 3222-3223 , denotes ,
T13122 3224-3229 NNP denotes Stat3
T13123 3229-3230 , denotes ,
T13124 3231-3234 CC denotes and
T13125 3235-3240 JJ denotes total
T13126 3241-3245 NNP denotes IκBα
T13127 3246-3250 VBD denotes were
T13128 3251-3256 RB denotes still
T13129 3257-3264 JJ denotes present
T13130 3265-3267 IN denotes up
T13131 3268-3270 TO denotes to
T13132 3271-3280 NN denotes treatment
T13133 3281-3285 IN denotes with
T13134 3286-3288 CD denotes 15
T13135 3289-3291 NN denotes μM
T13136 3292-3295 CC denotes and
T13137 3296-3300 RB denotes then
T13138 3301-3305 VBD denotes were
T13139 3306-3308 RB denotes no
T13140 3309-3315 RB denotes longer
T13141 3316-3324 VBN denotes detected
T13142 3325-3326 -LRB- denotes (
T13143 3326-3332 NN denotes Figure
T13144 3333-3334 CD denotes 8
T13145 3334-3335 -RRB- denotes )
T13146 3335-3336 . denotes .
T13147 3337-3341 DT denotes This
T13148 3342-3349 NN denotes finding
T13149 3350-3358 VBZ denotes suggests
T13150 3359-3363 IN denotes that
T13151 3364-3374 NN denotes inhibition
T13152 3375-3377 IN denotes of
T13153 3378-3382 NNP denotes NFκB
T13154 3383-3386 MD denotes can
T13155 3387-3393 VB denotes induce
T13156 3394-3398 NN denotes cell
T13157 3399-3404 NN denotes death
T13158 3405-3407 IN denotes in
T13159 3408-3412 CD denotes LMP1
T13160 3413-3423 JJ denotes transgenic
T13161 3424-3435 NNS denotes lymphocytes
T13162 3436-3439 CC denotes and
T13163 3440-3448 NN denotes lymphoma
T13164 3449-3454 NNS denotes cells
T13165 3455-3462 IN denotes without
T13166 3463-3474 JJ denotes significant
T13167 3475-3482 NNS denotes effects
T13168 3483-3485 IN denotes on
T13169 3486-3496 NN denotes activation
T13170 3497-3499 IN denotes of
T13171 3500-3503 NNP denotes Akt
T13172 3504-3506 CC denotes or
T13173 3507-3512 NNP denotes Stat3
T13174 3512-3513 . denotes .
T13175 3514-3526 NNP denotes Cucurbitacin
T13176 3527-3528 PRP denotes I
T13177 3529-3537 VBZ denotes inhibits
T13178 3538-3548 NN denotes activation
T13179 3549-3551 IN denotes of
T13180 3552-3557 JJ denotes Stat3
T13181 3558-3560 IN denotes by
T13182 3561-3572 VBG denotes suppressing
T13183 3573-3576 DT denotes the
T13184 3577-3587 NN denotes activation
T13185 3588-3590 IN denotes of
T13186 3591-3594 PRP$ denotes its
T13187 3595-3601 NN denotes kinase
T13188 3602-3606 NN denotes JAK2
T13189 3606-3607 . denotes .
T13190 3608-3610 PRP denotes It
T13191 3611-3614 VBZ denotes has
T13192 3615-3619 VBN denotes been
T13193 3620-3625 VBN denotes shown
T13194 3626-3628 TO denotes to
T13195 3629-3640 RB denotes selectively
T13196 3641-3648 VB denotes inhibit
T13197 3649-3652 DT denotes the
T13198 3653-3659 NN denotes growth
T13199 3660-3662 IN denotes of
T13200 3663-3669 NNS denotes tumors
T13201 3670-3674 IN denotes with
T13202 3675-3689 RB denotes constitutively
T13203 3690-3699 VBN denotes activated
T13204 3700-3705 NNP denotes Stat3
T13205 3706-3707 NNP denotes [
T13206 3707-3709 CD denotes 47
T13207 3709-3710 NNP denotes ]
T13208 3710-3711 . denotes .
T13209 3712-3721 RB denotes Similarly
T13210 3721-3722 , denotes ,
T13211 3723-3727 NNP denotes LMP1
T13212 3728-3738 JJ denotes transgenic
T13213 3739-3750 NNS denotes lymphocytes
T13214 3751-3754 CC denotes and
T13215 3755-3763 NN denotes lymphoma
T13216 3764-3769 NNS denotes cells
T13217 3770-3774 VBD denotes were
T13218 3775-3786 JJ denotes susceptible
T13219 3787-3789 TO denotes to
T13220 3790-3802 VB denotes cucurbitacin
T13221 3803-3804 PRP denotes I
T13222 3805-3814 NN denotes treatment
T13223 3815-3823 VBG denotes starting
T13224 3824-3826 IN denotes at
T13225 3827-3830 CD denotes 0.1
T13226 3831-3833 NNP denotes μM
T13227 3833-3834 , denotes ,
T13228 3835-3836 DT denotes a
T13229 3837-3841 NN denotes dose
T13230 3842-3846 WDT denotes that
T13231 3847-3858 VBZ denotes corresponds
T13232 3859-3866 RB denotes closely
T13233 3867-3869 TO denotes to
T13234 3870-3873 DT denotes the
T13235 3874-3882 VBN denotes reported
T13236 3883-3887 NNP denotes IC50
T13237 3888-3890 IN denotes of
T13238 3891-3894 CD denotes 500
T13239 3895-3897 NNP denotes nM
T13240 3898-3899 -LRB- denotes (
T13241 3899-3905 NNP denotes Figure
T13242 3906-3907 CD denotes 7
T13243 3907-3908 -RRB- denotes )
T13244 3909-3910 NNP denotes [
T13245 3910-3912 CD denotes 47
T13246 3912-3913 NNP denotes ]
T13247 3913-3914 . denotes .
T13248 3915-3929 NNP denotes Phosphorylated
T13249 3930-3933 NNP denotes Akt
T13250 3933-3934 , denotes ,
T13251 3935-3940 NNP denotes Stat3
T13252 3940-3941 , denotes ,
T13253 3942-3945 CC denotes and
T13254 3946-3951 JJ denotes total
T13255 3952-3956 NNP denotes IκBα
T13256 3957-3961 VBD denotes were
T13257 3962-3965 RB denotes not
T13258 3966-3976 JJ denotes detectable
T13259 3977-3981 IN denotes past
T13260 3982-3983 CD denotes 1
T13261 3984-3986 NNP denotes μM
T13262 3987-3990 CC denotes and
T13263 3991-3993 IN denotes at
T13264 3994-4000 JJR denotes higher
T13265 4001-4006 NNS denotes doses
T13266 4007-4010 DT denotes all
T13267 4011-4018 NN denotes protein
T13268 4019-4025 NNS denotes levels
T13269 4026-4030 VBD denotes were
T13270 4031-4038 RB denotes greatly
T13271 4039-4048 VBN denotes decreased
T13272 4048-4049 , denotes ,
T13273 4050-4060 JJ denotes indicative
T13274 4061-4063 IN denotes of
T13275 4064-4067 DT denotes the
T13276 4068-4073 JJ denotes total
T13277 4074-4078 NN denotes loss
T13278 4079-4081 IN denotes of
T13279 4082-4091 NN denotes viability
T13280 4092-4093 -LRB- denotes (
T13281 4093-4099 NN denotes Figure
T13282 4100-4101 CD denotes 8
T13283 4101-4102 -RRB- denotes )
T13284 4102-4103 . denotes .
T13285 4104-4105 DT denotes A
T13286 4106-4112 NN denotes second
T13287 4113-4121 VBD denotes reported
T13288 4122-4131 NN denotes inhibitor
T13289 4132-4134 IN denotes of
T13290 4135-4140 NNP denotes Stat3
T13291 4140-4141 , denotes ,
T13292 4142-4147 NNP denotes AG490
T13293 4147-4148 , denotes ,
T13294 4149-4152 VBD denotes had
T13295 4153-4155 DT denotes no
T13296 4156-4162 NN denotes effect
T13297 4163-4165 IN denotes on
T13298 4166-4172 NN denotes growth
T13299 4173-4174 -LRB- denotes (
T13300 4174-4180 NN denotes Figure
T13301 4181-4182 CD denotes 7
T13302 4182-4183 -RRB- denotes )
T13303 4183-4184 , denotes ,
T13304 4185-4188 CC denotes but
T13305 4189-4199 NN denotes activation
T13306 4200-4202 IN denotes of
T13307 4203-4206 NNP denotes Akt
T13308 4206-4207 , denotes ,
T13309 4208-4213 NNP denotes Stat3
T13310 4213-4214 , denotes ,
T13311 4215-4217 CC denotes or
T13312 4218-4224 NNS denotes levels
T13313 4225-4227 IN denotes of
T13314 4228-4232 NNP denotes IκBα
T13315 4233-4237 VBD denotes were
T13316 4238-4242 RB denotes also
T13317 4243-4246 RB denotes not
T13318 4247-4255 JJ denotes affected
T13319 4256-4257 -LRB- denotes (
T13320 4257-4263 NN denotes Figure
T13321 4264-4265 CD denotes 8
T13322 4265-4266 -RRB- denotes )
T13323 4266-4267 . denotes .
T13324 4268-4273 DT denotes These
T13325 4274-4282 NNS denotes findings
T13326 4283-4290 VBP denotes suggest
T13327 4291-4295 IN denotes that
T13328 4296-4306 NN denotes inhibition
T13329 4307-4309 IN denotes of
T13330 4310-4315 NNP denotes Stat3
T13331 4316-4319 MD denotes can
T13332 4320-4326 VB denotes induce
T13333 4327-4331 NN denotes cell
T13334 4332-4337 NN denotes death
T13335 4338-4340 IN denotes in
T13336 4341-4345 CD denotes LMP1
T13337 4346-4356 JJ denotes transgenic
T13338 4357-4368 NNS denotes lymphocytes
T13339 4369-4372 CC denotes and
T13340 4373-4381 NN denotes lymphoma
T13341 4382-4387 NNS denotes cells
T13342 4387-4388 , denotes ,
T13343 4389-4392 CC denotes but
T13344 4393-4398 JJ denotes Stat3
T13345 4399-4409 NN denotes inhibition
T13346 4410-4414 RB denotes also
T13347 4415-4418 VBZ denotes has
T13348 4419-4431 JJ denotes considerable
T13349 4432-4441 NN denotes crossover
T13350 4442-4449 NNS denotes effects
T13351 4450-4452 IN denotes on
T13352 4453-4456 NNP denotes Akt
T13353 4457-4460 CC denotes and
T13354 4461-4465 NNP denotes NFκB
T13355 4466-4475 VBG denotes signaling
T13356 4475-4476 . denotes .
T13357 4477-4481 CD denotes LMP1
T13358 4482-4485 VBZ denotes has
T13359 4486-4490 RB denotes also
T13360 4491-4495 VBN denotes been
T13361 4496-4501 VBN denotes shown
T13362 4502-4504 TO denotes to
T13363 4505-4513 VB denotes activate
T13364 4514-4517 NNP denotes JNK
T13365 4518-4521 CC denotes and
T13366 4522-4525 CD denotes p38
T13367 4526-4530 NNP denotes MAPK
T13368 4531-4539 NNS denotes pathways
T13369 4540-4541 NNP denotes [
T13370 4541-4546 CD denotes 13,48
T13371 4546-4547 NNP denotes ]
T13372 4547-4548 , denotes ,
T13373 4549-4552 CC denotes and
T13374 4553-4557 NNP denotes LMP1
T13375 4558-4568 JJ denotes transgenic
T13376 4569-4580 NNS denotes lymphocytes
T13377 4581-4585 VBD denotes were
T13378 4586-4592 RB denotes mildly
T13379 4593-4604 JJ denotes susceptible
T13380 4605-4607 TO denotes to
T13381 4608-4614 NN denotes growth
T13382 4615-4625 NN denotes inhibition
T13383 4626-4628 IN denotes by
T13384 4629-4637 NNP denotes SB202190
T13385 4637-4638 , denotes ,
T13386 4639-4641 DT denotes an
T13387 4642-4651 NN denotes inhibitor
T13388 4652-4654 IN denotes of
T13389 4655-4658 CD denotes p38
T13390 4659-4663 NNP denotes MAPK
T13391 4663-4664 , denotes ,
T13392 4665-4668 CC denotes but
T13393 4669-4672 RB denotes not
T13394 4673-4678 NNP denotes U0126
T13395 4678-4679 , denotes ,
T13396 4680-4682 DT denotes an
T13397 4683-4692 NN denotes inhibitor
T13398 4693-4695 IN denotes of
T13399 4696-4702 NNP denotes MEK1/2
T13400 4703-4711 NN denotes activity
T13401 4711-4712 . denotes .
T13402 4713-4720 RB denotes However
T13403 4720-4721 , denotes ,
T13404 4722-4729 NNS denotes effects
T13405 4730-4732 IN denotes of
T13406 4733-4741 CD denotes SB202190
T13407 4742-4746 VBD denotes were
T13408 4747-4751 RB denotes only
T13409 4752-4760 JJ denotes apparent
T13410 4761-4763 IN denotes at
T13411 4764-4768 JJ denotes high
T13412 4769-4774 NNS denotes doses
T13413 4775-4776 -LRB- denotes (
T13414 4776-4777 CD denotes >
T13415 4777-4779 CD denotes 10
T13416 4780-4782 NNP denotes μM
T13417 4782-4783 -RRB- denotes )
T13418 4783-4784 , denotes ,
T13419 4785-4789 RB denotes much
T13420 4790-4796 JJR denotes higher
T13421 4797-4801 IN denotes than
T13422 4802-4805 DT denotes the
T13423 4806-4814 VBN denotes reported
T13424 4815-4819 NNP denotes IC50
T13425 4820-4822 IN denotes of
T13426 4823-4827 CD denotes 0.35
T13427 4828-4830 NNP denotes μM
T13428 4830-4831 , denotes ,
T13429 4832-4842 VBG denotes suggesting
T13430 4843-4847 IN denotes that
T13431 4848-4851 CD denotes p38
T13432 4852-4856 NNP denotes MAPK
T13433 4857-4861 VBZ denotes does
T13434 4862-4865 RB denotes not
T13435 4866-4879 RB denotes significantly
T13436 4880-4890 VB denotes contribute
T13437 4891-4893 TO denotes to
T13438 4894-4897 DT denotes the
T13439 4898-4906 JJ denotes enhanced
T13440 4907-4916 NN denotes viability
T13441 4917-4919 IN denotes in
T13442 4920-4924 CD denotes LMP1
T13443 4925-4935 JJ denotes transgenic
T13444 4936-4947 NNS denotes lymphocytes
T13445 4948-4950 CC denotes or
T13446 4951-4959 NN denotes lymphoma
T13447 4960-4965 NNS denotes cells
T13448 4966-4967 -LRB- denotes (
T13449 4967-4973 NN denotes Figure
T13450 4974-4975 CD denotes 7
T13451 4975-4976 -RRB- denotes )
T13452 4976-4977 . denotes .
T13453 4978-4991 RB denotes Interestingly
T13454 4991-4992 , denotes ,
T13455 4993-4997 DT denotes both
T13456 4998-5007 JJ denotes wild-type
T13457 5008-5011 CC denotes and
T13458 5012-5016 JJ denotes LMP1
T13459 5017-5027 JJ denotes transgenic
T13460 5028-5037 NNS denotes lymphomas
T13461 5038-5042 VBD denotes were
T13462 5043-5052 RB denotes similarly
T13463 5053-5064 JJ denotes susceptible
T13464 5065-5067 TO denotes to
T13465 5068-5079 VB denotes triciribine
T13466 5079-5080 , denotes ,
T13467 5081-5086 NNP denotes BAY11
T13468 5087-5091 CD denotes 7085
T13469 5091-5092 , denotes ,
T13470 5093-5096 CC denotes and
T13471 5097-5109 NN denotes cucurbitacin
T13472 5110-5111 PRP denotes I
T13473 5112-5122 NNS denotes treatments
T13474 5122-5123 , denotes ,
T13475 5124-5127 CC denotes but
T13476 5128-5131 RB denotes not
T13477 5132-5140 NNP denotes SB202190
T13478 5140-5141 , denotes ,
T13479 5142-5147 NNP denotes AG490
T13480 5147-5148 , denotes ,
T13481 5149-5151 CC denotes or
T13482 5152-5157 NNP denotes U0126
T13483 5158-5167 NN denotes treatment
T13484 5167-5168 , denotes ,
T13485 5169-5179 VBG denotes suggesting
T13486 5180-5184 IN denotes that
T13487 5185-5195 NN denotes activation
T13488 5196-5198 IN denotes of
T13489 5199-5202 NNP denotes Akt
T13490 5202-5203 , denotes ,
T13491 5204-5208 NNP denotes NFκB
T13492 5208-5209 , denotes ,
T13493 5210-5213 CC denotes and
T13494 5214-5219 NNP denotes Stat3
T13495 5220-5223 CC denotes but
T13496 5224-5227 RB denotes not
T13497 5228-5232 NNP denotes MAPK
T13498 5233-5241 NNS denotes pathways
T13499 5242-5245 VBP denotes are
T13500 5246-5261 NNS denotes characteristics
T13501 5262-5272 VBN denotes associated
T13502 5273-5277 IN denotes with
T13503 5278-5287 JJ denotes malignant
T13504 5288-5302 NN denotes transformation
T13505 5303-5304 -LRB- denotes (
T13506 5304-5310 NN denotes Figure
T13507 5311-5312 CD denotes 7
T13508 5312-5313 -RRB- denotes )
T13509 5313-5314 . denotes .
T13510 5315-5324 NN denotes rapamycin
T13511 5324-5325 , denotes ,
T13512 5326-5328 DT denotes an
T13513 5329-5338 NN denotes inhibitor
T13514 5339-5341 IN denotes of
T13515 5342-5346 NNP denotes mTOR
T13516 5346-5347 , denotes ,
T13517 5348-5351 VBD denotes did
T13518 5352-5355 RB denotes not
T13519 5356-5362 VB denotes affect
T13520 5363-5366 DT denotes the
T13521 5367-5376 NN denotes viability
T13522 5377-5379 IN denotes of
T13523 5380-5383 DT denotes the
T13524 5384-5394 JJ denotes transgenic
T13525 5395-5406 NNS denotes lymphocytes
T13526 5407-5409 CC denotes or
T13527 5410-5418 NN denotes lymphoma
T13528 5419-5424 NNS denotes cells
T13529 5424-5425 , denotes ,
T13530 5426-5436 VBG denotes confirming
T13531 5437-5441 IN denotes that
T13532 5442-5446 NNP denotes mTOR
T13533 5447-5449 VBZ denotes is
T13534 5450-5453 RB denotes not
T13535 5454-5462 VBN denotes targeted
T13536 5463-5465 IN denotes by
T13537 5466-5469 NNP denotes Akt
T13538 5470-5480 NN denotes activation
T13539 5481-5483 IN denotes in
T13540 5484-5488 CD denotes LMP1
T13541 5489-5499 JJ denotes transgenic
T13542 5500-5511 NNS denotes lymphocytes
T13543 5512-5514 CC denotes or
T13544 5515-5524 JJ denotes malignant
T13545 5525-5533 NN denotes lymphoma
T13546 5534-5539 NNS denotes cells
T13547 5540-5541 -LRB- denotes (
T13548 5541-5547 NN denotes Figure
T13549 5548-5549 CD denotes 7
T13550 5549-5550 -RRB- denotes )
T13551 5550-5551 . denotes .
T24974 1630-1633 NNP denotes Akt
T24975 1633-1634 , denotes ,
T24976 1635-1639 NNP denotes NFκB
T24977 1639-1640 , denotes ,
T24978 1641-1644 CC denotes and
T24979 1645-1650 NNP denotes Stat3
T24980 1651-1660 NNP denotes Signaling
T24981 1661-1664 VBP denotes Are
T24982 1665-1673 VBN denotes Required
T24983 1674-1677 IN denotes for
T24984 1678-1681 DT denotes the
T24985 1682-1688 NN denotes Growth
T24986 1689-1692 CC denotes and
T24987 1693-1701 NN denotes Survival
T24988 1702-1704 IN denotes of
T24989 1705-1713 NNP denotes Lymphoma
T24990 1714-1719 NNP denotes Cells
T24991 1720-1723 NNP denotes MTS
T24992 1724-1729 NN denotes assay
T24993 1730-1732 IN denotes of
T24994 1733-1744 NNS denotes splenocytes
T24995 1745-1749 IN denotes from
T24996 1750-1751 -LRB- denotes (
T24997 1751-1752 DT denotes A
T24998 1753-1756 CC denotes and
T24999 1757-1758 NNP denotes B
T25000 1758-1759 -RRB- denotes )
T25001 1760-1762 NNP denotes WT
T25002 1763-1765 CC denotes or
T25003 1766-1767 -LRB- denotes (
T25004 1767-1768 NNP denotes C
T25005 1769-1772 CC denotes and
T25006 1773-1774 NNP denotes D
T25007 1774-1775 -RRB- denotes )
T25008 1776-1780 CD denotes LMP1
T25009 1781-1791 JJ denotes transgenic
T25010 1792-1801 NNS denotes lymphomas
T25011 1802-1805 CC denotes and
T25012 1806-1807 -LRB- denotes (
T25013 1807-1808 NNP denotes E
T25014 1809-1812 CC denotes and
T25015 1813-1814 NN denotes F
T25016 1814-1815 -RRB- denotes )
T25017 1816-1820 CD denotes LMP1
T25018 1821-1831 JJ denotes transgenic
T25019 1832-1843 NNS denotes lymphoctyes
T25020 1843-1844 . denotes .
T25021 1845-1856 NNS denotes Splenocytes
T25022 1857-1861 VBD denotes were
T25023 1862-1870 VBN denotes cultured
T25024 1871-1875 IN denotes with
T25025 1876-1878 CC denotes or
T25026 1879-1886 IN denotes without
T25027 1887-1897 NNS denotes inhibitors
T25028 1898-1900 IN denotes of
T25029 1901-1905 NNP denotes NFκB
T25030 1906-1907 -LRB- denotes (
T25031 1907-1912 NNP denotes BAY11
T25032 1912-1913 -RRB- denotes )
T25033 1913-1914 , denotes ,
T25034 1915-1919 NNP denotes mTOR
T25035 1920-1921 -LRB- denotes (
T25036 1921-1930 NN denotes rapamycin
T25037 1930-1931 -RRB- denotes )
T25038 1931-1932 , denotes ,
T25039 1933-1936 NNP denotes Akt
T25040 1937-1938 -LRB- denotes (
T25041 1938-1949 NN denotes triciribine
T25042 1949-1950 -RRB- denotes )
T25043 1950-1951 , denotes ,
T25044 1952-1958 NNP denotes MEK1/2
T25045 1959-1960 -LRB- denotes (
T25046 1960-1965 NNP denotes U0126
T25047 1965-1966 -RRB- denotes )
T25048 1966-1967 , denotes ,
T25049 1968-1971 JJ denotes p38
T25050 1972-1973 -LRB- denotes (
T25051 1973-1981 CD denotes SB202190
T25052 1981-1982 -RRB- denotes )
T25053 1982-1983 , denotes ,
T25054 1984-1986 CC denotes or
T25055 1987-1992 NNP denotes Stat3
T25056 1993-1994 -LRB- denotes (
T25057 1994-2006 NN denotes cucurbitacin
T25058 2007-2008 PRP denotes I
T25059 2009-2012 CC denotes and
T25060 2013-2018 NNP denotes AG490
T25061 2018-2019 -RRB- denotes )
T25062 2020-2022 IN denotes at
T25063 2023-2026 DT denotes the
T25064 2027-2036 VBN denotes indicated
T25065 2037-2051 NNS denotes concentrations
T25066 2051-2052 . denotes .
T25067 2053-2056 DT denotes The
T25068 2057-2064 NNS denotes results
T25069 2065-2068 VBP denotes are
T25070 2069-2072 DT denotes the
T25071 2073-2077 JJ denotes mean
T25072 2078-2079 NN denotes ±
T25073 2080-2083 NNP denotes SEM
T25074 2084-2086 IN denotes of
T25075 2087-2097 NN denotes triplicate
T25076 2098-2105 NNS denotes samples
T25077 2105-2106 . denotes .
T25078 2107-2112 VBN denotes Shown
T25079 2113-2116 VBP denotes are
T25080 2117-2120 DT denotes the
T25081 2121-2128 NNS denotes results
T25082 2129-2132 IN denotes for
T25083 2133-2134 -LRB- denotes (
T25084 2134-2135 DT denotes A
T25085 2136-2139 CC denotes and
T25086 2140-2141 NNP denotes B
T25087 2141-2142 -RRB- denotes )
T25088 2143-2145 NNP denotes WT
T25089 2146-2154 NN denotes lymphoma
T25090 2155-2156 CD denotes 1
T25091 2156-2157 , denotes ,
T25092 2158-2159 -LRB- denotes (
T25093 2159-2160 NNP denotes C
T25094 2161-2164 CC denotes and
T25095 2165-2166 NNP denotes D
T25096 2166-2167 -RRB- denotes )
T25097 2168-2172 CD denotes LMP1
T25098 2173-2183 JJ denotes transgenic
T25099 2184-2192 NN denotes lymphoma
T25100 2193-2194 CD denotes 2
T25101 2194-2195 , denotes ,
T25102 2196-2199 CC denotes and
T25103 2200-2201 -LRB- denotes (
T25104 2201-2202 NNP denotes E
T25105 2203-2206 CC denotes and
T25106 2207-2208 NN denotes F
T25107 2208-2209 -RRB- denotes )
T25108 2210-2213 CD denotes one
T25109 2214-2217 IN denotes out
T25110 2218-2220 IN denotes of
T25111 2221-2224 CD denotes two
T25112 2225-2229 CD denotes LMP1
T25113 2230-2240 JJ denotes transgenic
T25114 2241-2245 NNS denotes mice
T25115 2246-2254 VBD denotes analyzed
T25116 2254-2255 . denotes .
T25117 2256-2260 DT denotes This
T25118 2261-2269 NN denotes analysis
T25119 2270-2273 VBD denotes was
T25120 2274-2282 VBN denotes repeated
T25121 2283-2287 IN denotes with
T25122 2288-2292 CD denotes LMP1
T25123 2293-2303 JJ denotes transgenic
T25124 2304-2312 NN denotes lymphoma
T25125 2313-2314 CD denotes 4
T25126 2315-2323 VBG denotes yielding
T25127 2324-2331 JJ denotes similar
T25128 2332-2339 NNS denotes results
T25129 2339-2340 . denotes .
T25354 2351-2359 NN denotes Analysis
T25355 2360-2362 IN denotes of
T25356 2363-2366 NNP denotes Akt
T25357 2366-2367 , denotes ,
T25358 2368-2372 NNP denotes NFκB
T25359 2372-2373 , denotes ,
T25360 2374-2377 CC denotes and
T25361 2378-2383 NNP denotes Stat3
T25362 2384-2392 NNPS denotes Pathways
T25363 2393-2395 IN denotes in
T25364 2396-2408 NN denotes Contribution
T25365 2409-2411 TO denotes to
T25366 2412-2415 DT denotes the
T25367 2416-2422 NN denotes Growth
T25368 2423-2426 CC denotes and
T25369 2427-2435 NN denotes Survival
T25370 2436-2438 IN denotes of
T25371 2439-2447 NNP denotes Lymphoma
T25372 2448-2453 NNP denotes Cells
T25373 2454-2455 -LRB- denotes (
T25374 2455-2456 DT denotes A
T25375 2457-2458 NNP denotes D
T25376 2458-2459 -RRB- denotes )
T25377 2460-2470 NNP denotes Immunoblot
T25378 2471-2479 NN denotes analysis
T25379 2480-2482 IN denotes of
T25380 2483-2492 JJ denotes wild-type
T25381 2493-2496 CC denotes and
T25382 2497-2501 JJ denotes LMP1
T25383 2502-2512 JJ denotes transgenic
T25384 2513-2522 NNS denotes lymphomas
T25385 2523-2526 IN denotes for
T25386 2527-2530 NNP denotes Akt
T25387 2530-2531 , denotes ,
T25388 2532-2536 NNP denotes NFκB
T25389 2536-2537 , denotes ,
T25390 2538-2541 CC denotes and
T25391 2542-2547 JJ denotes Stat3
T25392 2548-2557 VBG denotes signaling
T25393 2558-2563 IN denotes after
T25394 2564-2573 NN denotes treatment
T25395 2574-2578 IN denotes with
T25396 2579-2580 -LRB- denotes (
T25397 2580-2581 NN denotes A
T25398 2581-2582 -RRB- denotes )
T25399 2583-2585 DT denotes an
T25400 2586-2589 NNP denotes Akt
T25401 2590-2599 NN denotes inhibitor
T25402 2599-2600 , denotes ,
T25403 2601-2612 NN denotes triciribine
T25404 2612-2613 , denotes ,
T25405 2614-2615 -LRB- denotes (
T25406 2615-2616 NNP denotes B
T25407 2616-2617 -RRB- denotes )
T25408 2618-2620 DT denotes an
T25409 2621-2625 NN denotes NFκB
T25410 2626-2635 NN denotes inhibitor
T25411 2635-2636 , denotes ,
T25412 2637-2642 NNP denotes BAY11
T25413 2643-2647 CD denotes 7085
T25414 2647-2648 , denotes ,
T25415 2649-2652 CC denotes and
T25416 2653-2656 DT denotes the
T25417 2657-2662 JJ denotes Stat3
T25418 2663-2673 NNS denotes inhibitors
T25419 2674-2675 -LRB- denotes (
T25420 2675-2676 NNP denotes C
T25421 2676-2677 -RRB- denotes )
T25422 2678-2690 NN denotes cucurbitacin
T25423 2691-2692 PRP denotes I
T25424 2693-2696 CC denotes and
T25425 2697-2698 -LRB- denotes (
T25426 2698-2699 NNP denotes D
T25427 2699-2700 -RRB- denotes )
T25428 2701-2706 NNP denotes AG490
T25429 2706-2707 , denotes ,
T25430 2708-2710 IN denotes at
T25431 2711-2714 DT denotes the
T25432 2715-2724 VBN denotes indicated
T25433 2725-2739 NNS denotes concentrations
T25434 2739-2740 . denotes .
T25435 2741-2747 NNS denotes Arrows
T25436 2748-2756 VBP denotes indicate
T25437 2757-2760 DT denotes the
T25438 2761-2770 NNS denotes positions
T25439 2771-2773 IN denotes of
T25440 2774-2775 NN denotes α
T25441 2776-2779 CC denotes and
T25442 2780-2781 NN denotes β
T25443 2782-2790 NNS denotes isoforms
T25444 2791-2793 IN denotes of
T25445 2794-2799 NNP denotes Stat3
T25446 2799-2800 . denotes .
T25447 2801-2806 NNP denotes Actin
T25448 2807-2810 VBD denotes was
T25449 2811-2815 VBN denotes used
T25450 2816-2818 IN denotes as
T25451 2819-2820 DT denotes a
T25452 2821-2828 VBG denotes loading
T25453 2829-2836 NN denotes control
T25454 2836-2837 . denotes .
R9671 T12763 T12778 nummod LMP1,Pathways
R9672 T12764 T12778 compound Promotes,Pathways
R9673 T12765 T12778 compound Tumor,Pathways
R9674 T12766 T12769 preconj Growth,through
R9675 T12767 T12766 cc and,Growth
R9676 T12768 T12766 conj Survival,Growth
R9677 T12769 T12778 prep through,Pathways
R9678 T12770 T12769 pobj Activation,through
R9679 T12771 T12770 prep of,Activation
R9680 T12772 T12771 pobj Akt,of
R9681 T12773 T12772 punct ",",Akt
R9682 T12774 T12772 conj NFκB,Akt
R9683 T12775 T12774 punct ",",NFκB
R9684 T12776 T12774 cc and,NFκB
R9685 T12777 T12774 conj Stat3,NFκB
R9686 T12778 T12780 nsubj Pathways,explore
R9687 T12779 T12780 aux To,explore
R9688 T12780 T12780 ROOT explore,explore
R9689 T12781 T12782 det which,pathways
R9690 T12782 T12784 nsubjpass pathways,required
R9691 T12783 T12784 auxpass were,required
R9692 T12784 T12780 ccomp required,explore
R9693 T12785 T12784 prep for,required
R9694 T12786 T12788 det the,growth
R9695 T12787 T12788 amod enhanced,growth
R9696 T12788 T12785 pobj growth,for
R9697 T12789 T12788 cc and,growth
R9698 T12790 T12788 conj survival,growth
R9699 T12791 T12790 prep of,survival
R9700 T12792 T12793 amod LMP1-induced,lymphomas
R9701 T12793 T12791 pobj lymphomas,of
R9702 T12794 T12780 punct ",",explore
R9703 T12795 T12803 nsubjpass splenocytes,cultured
R9704 T12796 T12795 prep from,splenocytes
R9705 T12797 T12801 amod wild-type,mice
R9706 T12798 T12797 cc and,wild-type
R9707 T12799 T12797 conj LMP1,wild-type
R9708 T12800 T12801 amod transgenic,mice
R9709 T12801 T12796 pobj mice,from
R9710 T12802 T12803 auxpass were,cultured
R9711 T12803 T12780 conj cultured,explore
R9712 T12804 T12803 prep in,cultured
R9713 T12805 T12806 det the,presence
R9714 T12806 T12804 pobj presence,in
R9715 T12807 T12806 prep of,presence
R9716 T12808 T12807 pobj inhibitors,of
R9717 T12809 T12808 prep for,inhibitors
R9718 T12810 T12809 pobj Akt,for
R9719 T12811 T12810 punct ",",Akt
R9720 T12812 T12810 conj NFκB,Akt
R9721 T12813 T12812 punct ",",NFκB
R9722 T12814 T12812 conj Stat3,NFκB
R9723 T12815 T12814 punct ",",Stat3
R9724 T12816 T12814 conj mTOR,Stat3
R9725 T12817 T12816 punct ",",mTOR
R9726 T12818 T12816 cc or,mTOR
R9727 T12819 T12816 conj MAPK,mTOR
R9728 T12820 T12803 cc and,cultured
R9729 T12821 T12803 conj assayed,cultured
R9730 T12822 T12821 prep for,assayed
R9731 T12823 T12822 pobj growth,for
R9732 T12824 T12823 cc and,growth
R9733 T12825 T12823 conj survival,growth
R9734 T12826 T12821 agent by,assayed
R9735 T12827 T12829 det the,assay
R9736 T12828 T12829 compound MTS,assay
R9737 T12829 T12826 pobj assay,by
R9738 T12830 T12780 punct .,explore
R9739 T12831 T12833 mark As,shown
R9740 T12832 T12833 advmod previously,shown
R9741 T12833 T12837 advcl shown,were
R9742 T12834 T12837 punct ",",were
R9743 T12835 T12836 amod wild-type,lymphocytes
R9744 T12836 T12837 nsubj lymphocytes,were
R9745 T12837 T12837 ROOT were,were
R9746 T12838 T12837 neg not,were
R9747 T12839 T12837 acomp viable,were
R9748 T12840 T12839 prep in,viable
R9749 T12841 T12840 pobj culture,in
R9750 T12842 T12837 cc and,were
R9751 T12843 T12846 aux could,tested
R9752 T12844 T12846 neg not,tested
R9753 T12845 T12846 auxpass be,tested
R9754 T12846 T12837 conj tested,were
R9755 T12847 T12846 prep with,tested
R9756 T12848 T12849 det the,inhibitors
R9757 T12849 T12847 pobj inhibitors,with
R9758 T12850 T12837 punct .,were
R9759 T12851 T12862 advmod However,blocked
R9760 T12852 T12862 punct ",",blocked
R9761 T12853 T12855 det the,viability
R9762 T12854 T12855 amod enhanced,viability
R9763 T12855 T12862 nsubjpass viability,blocked
R9764 T12856 T12855 prep of,viability
R9765 T12857 T12859 nummod LMP1,lymphocytes
R9766 T12858 T12859 amod transgenic,lymphocytes
R9767 T12859 T12856 pobj lymphocytes,of
R9768 T12860 T12862 auxpass was,blocked
R9769 T12861 T12862 advmod effectively,blocked
R9770 T12862 T12862 ROOT blocked,blocked
R9771 T12863 T12862 agent by,blocked
R9772 T12864 T12863 pobj treatment,by
R9773 T12865 T12862 prep with,blocked
R9774 T12866 T12865 pobj triciribine,with
R9775 T12867 T12866 punct ",",triciribine
R9776 T12868 T12866 appos BAY11,triciribine
R9777 T12869 T12866 appos 7085,triciribine
R9778 T12870 T12866 punct ",",triciribine
R9779 T12871 T12866 conj cucurbitacin,triciribine
R9780 T12872 T12871 conj I,cucurbitacin
R9781 T12873 T12872 punct ",",I
R9782 T12874 T12872 cc and,I
R9783 T12875 T12876 advmod slightly,with
R9784 T12876 T12862 prep with,blocked
R9785 T12877 T12876 pobj SB203580,with
R9786 T12878 T12862 punct ",",blocked
R9787 T12879 T12862 cc but,blocked
R9788 T12880 T12881 neg not,by
R9789 T12881 T12862 conj by,blocked
R9790 T12882 T12881 pobj treatment,by
R9791 T12883 T12881 conj with,by
R9792 T12884 T12883 pobj rapamycin,with
R9793 T12885 T12884 punct ",",rapamycin
R9794 T12886 T12884 conj U0126,rapamycin
R9795 T12887 T12886 punct ",",U0126
R9796 T12888 T12886 cc or,U0126
R9797 T12889 T12886 conj AG490,U0126
R9798 T12890 T12891 punct (,Figure
R9799 T12891 T12889 appos Figure,AG490
R9800 T12892 T12891 nummod 7,Figure
R9801 T12893 T12889 punct ),AG490
R9802 T12894 T12862 punct .,blocked
R9803 T12895 T12896 nsubj Triciribine,inhibits
R9804 T12896 T12896 ROOT inhibits,inhibits
R9805 T12897 T12898 det the,activation
R9806 T12898 T12896 dobj activation,inhibits
R9807 T12899 T12898 prep of,activation
R9808 T12900 T12899 pobj Akt,of
R9809 T12901 T12896 cc and,inhibits
R9810 T12902 T12907 prep at,shown
R9811 T12903 T12904 nummod 20,μM
R9812 T12904 T12902 pobj μM,at
R9813 T12905 T12907 aux has,shown
R9814 T12906 T12907 auxpass been,shown
R9815 T12907 T12896 conj shown,inhibits
R9816 T12908 T12909 aux to,induce
R9817 T12909 T12907 xcomp induce,shown
R9818 T12910 T12911 compound growth,arrest
R9819 T12911 T12909 dobj arrest,induce
R9820 T12912 T12909 prep in,induce
R9821 T12913 T12914 compound cancer,cells
R9822 T12914 T12912 pobj cells,in
R9823 T12915 T12909 prep with,induce
R9824 T12916 T12918 amod aberrant,activity
R9825 T12917 T12918 compound Akt,activity
R9826 T12918 T12921 compound activity,]
R9827 T12919 T12921 nmod [,]
R9828 T12920 T12921 nummod 46,]
R9829 T12921 T12915 pobj ],with
R9830 T12922 T12896 punct .,inhibits
R9831 T12923 T12924 det The,effects
R9832 T12924 T12936 nsubj effects,were
R9833 T12925 T12924 prep of,effects
R9834 T12926 T12925 pobj triciribine,of
R9835 T12927 T12924 prep on,effects
R9836 T12928 T12929 compound cell,growth
R9837 T12929 T12927 pobj growth,on
R9838 T12930 T12929 prep of,growth
R9839 T12931 T12933 det the,lymphocytes
R9840 T12932 T12933 amod transgenic,lymphocytes
R9841 T12933 T12930 pobj lymphocytes,of
R9842 T12934 T12933 cc and,lymphocytes
R9843 T12935 T12933 conj lymphomas,lymphocytes
R9844 T12936 T12936 ROOT were,were
R9845 T12937 T12936 acomp apparent,were
R9846 T12938 T12939 advmod as,low
R9847 T12939 T12937 amod low,apparent
R9848 T12940 T12939 prep as,low
R9849 T12941 T12942 nummod 1,μM
R9850 T12942 T12940 pobj μM,as
R9851 T12943 T12936 punct ",",were
R9852 T12944 T12936 advcl suggesting,were
R9853 T12945 T12950 mark that,required
R9854 T12946 T12950 nsubjpass activation,required
R9855 T12947 T12946 prep of,activation
R9856 T12948 T12947 pobj Akt,of
R9857 T12949 T12950 auxpass is,required
R9858 T12950 T12944 ccomp required,suggesting
R9859 T12951 T12950 prep for,required
R9860 T12952 T12953 det the,survival
R9861 T12953 T12951 pobj survival,for
R9862 T12954 T12953 cc and,survival
R9863 T12955 T12953 conj growth,survival
R9864 T12956 T12953 prep of,survival
R9865 T12957 T12959 nummod LMP1,lymphocytes
R9866 T12958 T12959 amod transgenic,lymphocytes
R9867 T12959 T12956 pobj lymphocytes,of
R9868 T12960 T12959 cc and,lymphocytes
R9869 T12961 T12962 compound lymphoma,cells
R9870 T12962 T12959 conj cells,lymphocytes
R9871 T12963 T12964 punct (,Figure
R9872 T12964 T12959 appos Figure,lymphocytes
R9873 T12965 T12964 nummod 7,Figure
R9874 T12966 T12964 punct ),Figure
R9875 T12967 T12936 punct .,were
R9876 T12968 T12969 det The,effects
R9877 T12969 T12974 nsubjpass effects,assessed
R9878 T12970 T12969 prep of,effects
R9879 T12971 T12972 det the,inhibitors
R9880 T12972 T12970 pobj inhibitors,of
R9881 T12973 T12974 auxpass were,assessed
R9882 T12974 T12974 ROOT assessed,assessed
R9883 T12975 T12974 prep by,assessed
R9884 T12976 T12975 pcomp identifying,by
R9885 T12977 T12978 compound phosphorylated,Akt
R9886 T12978 T12976 dobj Akt,identifying
R9887 T12979 T12978 punct ",",Akt
R9888 T12980 T12978 conj Stat3,Akt
R9889 T12981 T12980 punct ",",Stat3
R9890 T12982 T12980 cc and,Stat3
R9891 T12983 T12984 amod total,levels
R9892 T12984 T12978 appos levels,Akt
R9893 T12985 T12984 prep of,levels
R9894 T12986 T12985 pobj IκBα,of
R9895 T12987 T12988 punct (,Figure
R9896 T12988 T12986 appos Figure,IκBα
R9897 T12989 T12988 nummod 8,Figure
R9898 T12990 T12986 punct ),IκBα
R9899 T12991 T12974 punct .,assessed
R9900 T12992 T13004 nsubj Treatment,was
R9901 T12993 T12992 prep with,Treatment
R9902 T12994 T12997 amod triciribine,phosphorylation
R9903 T12995 T12996 advmod effectively,blocked
R9904 T12996 T12997 amod blocked,phosphorylation
R9905 T12997 T12993 pobj phosphorylation,with
R9906 T12998 T12997 prep of,phosphorylation
R9907 T12999 T12998 pobj Akt,of
R9908 T13000 T12992 punct ",",Treatment
R9909 T13001 T12992 cc and,Treatment
R9910 T13002 T13003 compound phosphorylated,Akt
R9911 T13003 T12992 conj Akt,Treatment
R9912 T13004 T13007 auxpass was,detected
R9913 T13005 T13006 neg no,longer
R9914 T13006 T13007 advmod longer,detected
R9915 T13007 T13007 ROOT detected,detected
R9916 T13008 T13010 amod past,μM
R9917 T13009 T13010 nummod 5,μM
R9918 T13010 T13007 dobj μM,detected
R9919 T13011 T13007 punct .,detected
R9920 T13012 T13013 compound Phosphorylated,Stat3
R9921 T13013 T13016 nsubj Stat3,were
R9922 T13014 T13013 cc and,Stat3
R9923 T13015 T13013 conj IκBα,Stat3
R9924 T13016 T13016 ROOT were,were
R9925 T13017 T13016 advmod still,were
R9926 T13018 T13016 acomp present,were
R9927 T13019 T13018 prep at,present
R9928 T13020 T13021 nummod 25,μM
R9929 T13021 T13019 pobj μM,at
R9930 T13022 T13016 punct .,were
R9931 T13023 T13024 det These,findings
R9932 T13024 T13025 nsubj findings,suggest
R9933 T13025 T13025 ROOT suggest,suggest
R9934 T13026 T13029 mark that,targets
R9935 T13027 T13029 nsubj triciribine,targets
R9936 T13028 T13029 advmod specifically,targets
R9937 T13029 T13025 ccomp targets,suggest
R9938 T13030 T13029 dobj Akt,targets
R9939 T13031 T13029 cc and,targets
R9940 T13032 T13036 mark that,required
R9941 T13033 T13034 compound Akt,activation
R9942 T13034 T13036 nsubjpass activation,required
R9943 T13035 T13036 auxpass is,required
R9944 T13036 T13029 conj required,targets
R9945 T13037 T13036 prep for,required
R9946 T13038 T13040 det the,viability
R9947 T13039 T13040 amod enhanced,viability
R9948 T13040 T13037 pobj viability,for
R9949 T13041 T13040 prep of,viability
R9950 T13042 T13044 det the,lymphocytes
R9951 T13043 T13044 amod transgenic,lymphocytes
R9952 T13044 T13041 pobj lymphocytes,of
R9953 T13045 T13044 cc and,lymphocytes
R9954 T13046 T13047 compound lymphoma,cells
R9955 T13047 T13044 conj cells,lymphocytes
R9956 T13048 T13025 punct .,suggest
R9957 T13049 T13054 nsubj Inhibition,induces
R9958 T13050 T13049 prep of,Inhibition
R9959 T13051 T13050 pobj NFκB,of
R9960 T13052 T13054 nsubj signaling,induces
R9961 T13053 T13054 advmod rapidly,induces
R9962 T13054 T13054 ROOT induces,induces
R9963 T13055 T13056 compound cell,death
R9964 T13056 T13054 dobj death,induces
R9965 T13057 T13056 prep of,death
R9966 T13058 T13059 amod EBV-transformed,lymphocytes
R9967 T13059 T13057 pobj lymphocytes,of
R9968 T13060 T13062 compound [,]
R9969 T13061 T13062 compound "17,18",]
R9970 T13062 T13054 dobj ],induces
R9971 T13063 T13054 punct .,induces
R9972 T13064 T13075 nsubj BAY11,decreased
R9973 T13065 T13064 appos 7085,BAY11
R9974 T13066 T13064 punct ",",BAY11
R9975 T13067 T13068 det an,inhibitor
R9976 T13068 T13064 appos inhibitor,BAY11
R9977 T13069 T13068 prep of,inhibitor
R9978 T13070 T13069 pobj NFκB,of
R9979 T13071 T13068 acl signaling,inhibitor
R9980 T13072 T13071 punct ",",signaling
R9981 T13073 T13075 advmod also,decreased
R9982 T13074 T13075 advmod greatly,decreased
R9983 T13075 T13075 ROOT decreased,decreased
R9984 T13076 T13077 det the,viability
R9985 T13077 T13075 dobj viability,decreased
R9986 T13078 T13077 prep of,viability
R9987 T13079 T13082 det the,lymphocytes
R9988 T13080 T13082 compound LMP1,lymphocytes
R9989 T13081 T13082 compound transgenic,lymphocytes
R9990 T13082 T13078 pobj lymphocytes,of
R9991 T13083 T13082 cc and,lymphocytes
R9992 T13084 T13085 compound lymphoma,cells
R9993 T13085 T13082 conj cells,lymphocytes
R9994 T13086 T13075 prep at,decreased
R9995 T13087 T13086 pobj doses,at
R9996 T13088 T13089 advmod as,low
R9997 T13089 T13087 amod low,doses
R9998 T13090 T13089 prep as,low
R9999 T13091 T13092 nummod 1,μM
R10000 T13092 T13090 pobj μM,as
R10001 T13093 T13092 punct ",",μM
R10002 T13094 T13086 cc and,at
R10003 T13095 T13086 conj at,at
R10004 T13096 T13097 nummod 5,μM
R10005 T13097 T13095 pobj μM,at
R10006 T13098 T13099 det the,cells
R10007 T13099 T13100 nsubj cells,were
R10008 T13100 T13075 conj were,decreased
R10009 T13101 T13102 advmod completely,nonviable
R10010 T13102 T13100 acomp nonviable,were
R10011 T13103 T13104 punct (,Figure
R10012 T13104 T13102 parataxis Figure,nonviable
R10013 T13105 T13104 nummod 7,Figure
R10014 T13106 T13104 punct ),Figure
R10015 T13107 T13100 punct .,were
R10039 T13131 T13129 prep to,present
R10040 T13132 T13131 pobj treatment,to
R10041 T13133 T13129 prep with,present
R10042 T13134 T13135 nummod 15,μM
R10043 T13135 T13133 pobj μM,with
R10044 T13136 T13127 cc and,were
R10045 T13137 T13141 advmod then,detected
R10046 T13138 T13141 auxpass were,detected
R10047 T13139 T13140 neg no,longer
R10048 T13140 T13141 advmod longer,detected
R10049 T13141 T13127 conj detected,were
R10050 T13142 T13143 punct (,Figure
R10051 T13143 T13141 oprd Figure,detected
R10052 T13144 T13143 nummod 8,Figure
R10053 T13145 T13143 punct ),Figure
R10054 T13146 T13127 punct .,were
R10055 T13147 T13148 det This,finding
R10056 T13148 T13149 nsubj finding,suggests
R10057 T13149 T13149 ROOT suggests,suggests
R10058 T13150 T13155 mark that,induce
R10059 T13151 T13155 nsubj inhibition,induce
R10060 T13152 T13151 prep of,inhibition
R10061 T13153 T13152 pobj NFκB,of
R10062 T13154 T13155 aux can,induce
R10063 T13155 T13149 ccomp induce,suggests
R10064 T13156 T13157 compound cell,death
R10065 T13157 T13155 dobj death,induce
R10066 T13158 T13155 prep in,induce
R10067 T13159 T13161 nummod LMP1,lymphocytes
R10068 T13160 T13161 amod transgenic,lymphocytes
R10069 T13161 T13158 pobj lymphocytes,in
R10070 T13162 T13161 cc and,lymphocytes
R10071 T13163 T13164 compound lymphoma,cells
R10072 T13164 T13161 conj cells,lymphocytes
R10073 T13165 T13155 prep without,induce
R10074 T13166 T13167 amod significant,effects
R10075 T13167 T13165 pobj effects,without
R10076 T13168 T13167 prep on,effects
R10077 T13169 T13168 pobj activation,on
R10078 T13170 T13169 prep of,activation
R10079 T13171 T13170 pobj Akt,of
R10080 T13172 T13171 cc or,Akt
R10081 T13173 T13171 conj Stat3,Akt
R10082 T13174 T13149 punct .,suggests
R10083 T13175 T13177 intj Cucurbitacin,inhibits
R10084 T13176 T13177 nsubj I,inhibits
R10085 T13177 T13177 ROOT inhibits,inhibits
R10086 T13178 T13177 dobj activation,inhibits
R10087 T13179 T13178 prep of,activation
R10088 T13180 T13179 pobj Stat3,of
R10089 T13181 T13177 prep by,inhibits
R10090 T13182 T13181 pcomp suppressing,by
R10091 T13183 T13184 det the,activation
R10092 T13184 T13182 dobj activation,suppressing
R10093 T13185 T13184 prep of,activation
R10094 T13186 T13188 poss its,JAK2
R10095 T13187 T13188 compound kinase,JAK2
R10096 T13188 T13185 pobj JAK2,of
R10097 T13189 T13177 punct .,inhibits
R10098 T13190 T13193 nsubjpass It,shown
R10099 T13191 T13193 aux has,shown
R10100 T13192 T13193 auxpass been,shown
R10101 T13193 T13193 ROOT shown,shown
R10102 T13194 T13196 aux to,inhibit
R10103 T13195 T13196 advmod selectively,inhibit
R10104 T13196 T13193 xcomp inhibit,shown
R10105 T13197 T13198 det the,growth
R10106 T13198 T13196 dobj growth,inhibit
R10107 T13199 T13198 prep of,growth
R10108 T13200 T13199 pobj tumors,of
R10109 T13201 T13198 prep with,growth
R10110 T13202 T13203 nsubj constitutively,activated
R10111 T13203 T13205 amod activated,[
R10112 T13204 T13205 compound Stat3,[
R10113 T13205 T13201 pobj [,with
R10114 T13206 T13207 nummod 47,]
R10115 T13207 T13205 appos ],[
R10116 T13208 T13193 punct .,shown
R10117 T13209 T13217 advmod Similarly,were
R10118 T13210 T13217 punct ",",were
R10119 T13211 T13213 nmod LMP1,lymphocytes
R10120 T13212 T13213 amod transgenic,lymphocytes
R10121 T13213 T13217 nsubj lymphocytes,were
R10122 T13214 T13213 cc and,lymphocytes
R10123 T13215 T13216 compound lymphoma,cells
R10124 T13216 T13213 conj cells,lymphocytes
R10125 T13217 T13217 ROOT were,were
R10126 T13218 T13217 acomp susceptible,were
R10127 T13219 T13220 aux to,cucurbitacin
R10128 T13220 T13218 xcomp cucurbitacin,susceptible
R10129 T13221 T13222 compound I,treatment
R10130 T13222 T13220 dobj treatment,cucurbitacin
R10131 T13223 T13220 advcl starting,cucurbitacin
R10132 T13224 T13223 prep at,starting
R10133 T13225 T13226 nummod 0.1,μM
R10134 T13226 T13224 pobj μM,at
R10135 T13227 T13226 punct ",",μM
R10136 T13228 T13229 det a,dose
R10137 T13229 T13226 appos dose,μM
R10138 T13230 T13231 nsubj that,corresponds
R10139 T13231 T13229 relcl corresponds,dose
R10140 T13232 T13231 advmod closely,corresponds
R10141 T13233 T13231 prep to,corresponds
R10142 T13234 T13236 det the,IC50
R10143 T13235 T13236 amod reported,IC50
R10144 T13236 T13233 pobj IC50,to
R10145 T13237 T13236 prep of,IC50
R10146 T13238 T13239 nummod 500,nM
R10147 T13239 T13237 pobj nM,of
R10148 T13240 T13241 punct (,Figure
R10149 T13241 T13239 appos Figure,nM
R10150 T13242 T13241 nummod 7,Figure
R10151 T13243 T13239 punct ),nM
R10152 T13244 T13246 nmod [,]
R10153 T13245 T13246 nummod 47,]
R10154 T13246 T13236 appos ],IC50
R10155 T13247 T13217 punct .,were
R10156 T13248 T13249 compound Phosphorylated,Akt
R10157 T13249 T13256 nsubj Akt,were
R10158 T13250 T13249 punct ",",Akt
R10159 T13251 T13249 conj Stat3,Akt
R10160 T13252 T13251 punct ",",Stat3
R10161 T13253 T13251 cc and,Stat3
R10162 T13254 T13255 amod total,IκBα
R10163 T13255 T13251 conj IκBα,Stat3
R10164 T13256 T13256 ROOT were,were
R10165 T13257 T13256 neg not,were
R10166 T13258 T13256 acomp detectable,were
R10167 T13259 T13258 prep past,detectable
R10168 T13260 T13261 nummod 1,μM
R10169 T13261 T13259 pobj μM,past
R10170 T13262 T13256 cc and,were
R10171 T13263 T13271 prep at,decreased
R10194 T13286 T13287 nsubj second,reported
R10195 T13287 T13287 ROOT reported,reported
R10196 T13288 T13287 dobj inhibitor,reported
R10197 T13289 T13288 prep of,inhibitor
R10198 T13290 T13289 pobj Stat3,of
R10199 T13291 T13290 punct ",",Stat3
R10200 T13292 T13290 appos AG490,Stat3
R10201 T13293 T13294 punct ",",had
R10202 T13294 T13287 advcl had,reported
R10203 T13295 T13296 det no,effect
R10204 T13296 T13294 dobj effect,had
R10205 T13297 T13296 prep on,effect
R10206 T13298 T13297 pobj growth,on
R10207 T13299 T13300 punct (,Figure
R10208 T13300 T13298 appos Figure,growth
R10209 T13301 T13300 nummod 7,Figure
R10210 T13302 T13300 punct ),Figure
R10211 T13303 T13294 punct ",",had
R10212 T13304 T13287 cc but,reported
R10213 T13305 T13315 nsubj activation,were
R10214 T13306 T13305 prep of,activation
R10215 T13307 T13306 pobj Akt,of
R10216 T13308 T13307 punct ",",Akt
R10217 T13309 T13307 conj Stat3,Akt
R10218 T13310 T13309 punct ",",Stat3
R10219 T13311 T13309 cc or,Stat3
R10220 T13312 T13305 conj levels,activation
R10221 T13313 T13312 prep of,levels
R10222 T13314 T13313 pobj IκBα,of
R10223 T13315 T13287 conj were,reported
R10224 T13316 T13315 advmod also,were
R10225 T13317 T13318 neg not,affected
R10226 T13318 T13315 prep affected,were
R10227 T13319 T13320 punct (,Figure
R10249 T13341 T13338 conj cells,lymphocytes
R10273 T13365 T13364 cc and,JNK
R10274 T13366 T13368 nummod p38,pathways
R10275 T13367 T13368 compound MAPK,pathways
R10276 T13368 T13377 nsubj pathways,were
R10277 T13369 T13371 compound [,]
R10278 T13370 T13371 compound "13,48",]
R10279 T13371 T13368 appos ],pathways
R10280 T13372 T13371 punct ",",]
R10281 T13373 T13371 cc and,]
R10282 T13374 T13371 conj LMP1,]
R10283 T13375 T13376 amod transgenic,lymphocytes
R10284 T13376 T13368 conj lymphocytes,pathways
R10285 T13377 T13361 conj were,shown
R10286 T13378 T13379 advmod mildly,susceptible
R10287 T13379 T13377 acomp susceptible,were
R10288 T13380 T13379 prep to,susceptible
R10289 T13381 T13382 compound growth,inhibition
R10290 T13382 T13380 pobj inhibition,to
R10291 T13383 T13382 prep by,inhibition
R10292 T13384 T13383 pobj SB202190,by
R10293 T13385 T13384 punct ",",SB202190
R10294 T13386 T13387 det an,inhibitor
R10295 T13387 T13384 appos inhibitor,SB202190
R10296 T13388 T13387 prep of,inhibitor
R10297 T13389 T13390 nummod p38,MAPK
R10298 T13390 T13388 pobj MAPK,of
R10299 T13391 T13377 punct ",",were
R10300 T13392 T13377 cc but,were
R10301 T13393 T13394 neg not,U0126
R10302 T13394 T13394 ROOT U0126,U0126
R10303 T13395 T13394 punct ",",U0126
R10304 T13396 T13397 det an,inhibitor
R10305 T13397 T13394 appos inhibitor,U0126
R10328 T13420 T13407 acomp higher,were
R10329 T13421 T13420 prep than,higher
R10330 T13422 T13424 det the,IC50
R10331 T13423 T13424 amod reported,IC50
R10332 T13424 T13421 pobj IC50,than
R10333 T13425 T13424 prep of,IC50
R10334 T13426 T13427 nummod 0.35,μM
R10335 T13427 T13425 pobj μM,of
R10336 T13428 T13407 punct ",",were
R10337 T13429 T13407 advcl suggesting,were
R10338 T13430 T13436 mark that,contribute
R10339 T13431 T13432 compound p38,MAPK
R10340 T13432 T13436 nsubj MAPK,contribute
R10341 T13433 T13436 aux does,contribute
R10342 T13434 T13436 neg not,contribute
R10343 T13435 T13436 advmod significantly,contribute
R10344 T13436 T13429 ccomp contribute,suggesting
R10345 T13437 T13436 prep to,contribute
R10346 T13438 T13440 det the,viability
R10347 T13439 T13440 amod enhanced,viability
R10348 T13440 T13437 pobj viability,to
R10349 T13441 T13440 prep in,viability
R10350 T13442 T13444 nummod LMP1,lymphocytes
R10351 T13443 T13444 amod transgenic,lymphocytes
R10352 T13444 T13441 pobj lymphocytes,in
R10353 T13445 T13444 cc or,lymphocytes
R10354 T13446 T13447 compound lymphoma,cells
R10355 T13447 T13444 conj cells,lymphocytes
R10356 T13448 T13449 punct (,Figure
R10357 T13449 T13447 appos Figure,cells
R10358 T13450 T13449 nummod 7,Figure
R10359 T13451 T13449 punct ),Figure
R10360 T13452 T13407 punct .,were
R10361 T13453 T13461 advmod Interestingly,were
R10362 T13454 T13461 punct ",",were
R10363 T13455 T13456 preconj both,wild-type
R10364 T13456 T13460 amod wild-type,lymphomas
R10365 T13457 T13456 cc and,wild-type
R10366 T13458 T13456 conj LMP1,wild-type
R10367 T13459 T13460 amod transgenic,lymphomas
R10368 T13460 T13461 nsubj lymphomas,were
R10369 T13461 T13461 ROOT were,were
R10370 T13462 T13463 advmod similarly,susceptible
R10371 T13463 T13461 acomp susceptible,were
R10372 T13464 T13463 prep to,susceptible
R10373 T13465 T13464 pobj triciribine,to
R10374 T13466 T13461 punct ",",were
R10375 T13467 T13473 nmod BAY11,treatments
R10376 T13468 T13467 appos 7085,BAY11
R10377 T13469 T13467 punct ",",BAY11
R10378 T13470 T13467 cc and,BAY11
R10379 T13471 T13467 conj cucurbitacin,BAY11
R10380 T13472 T13473 nsubj I,treatments
R10381 T13473 T13461 advcl treatments,were
R10382 T13474 T13473 punct ",",treatments
R10383 T13475 T13473 cc but,treatments
R10384 T13476 T13477 neg not,SB202190
R10385 T13477 T13473 conj SB202190,treatments
R10386 T13478 T13477 punct ",",SB202190
R10387 T13479 T13477 conj AG490,SB202190
R10388 T13480 T13479 punct ",",AG490
R10389 T13481 T13479 cc or,AG490
R10390 T13482 T13479 conj U0126,AG490
R10391 T13483 T13473 conj treatment,treatments
R10392 T13484 T13461 punct ",",were
R10393 T13485 T13461 advcl suggesting,were
R10394 T13486 T13499 mark that,are
R10395 T13487 T13499 nsubj activation,are
R10396 T13488 T13487 prep of,activation
R10397 T13489 T13488 pobj Akt,of
R10398 T13490 T13489 punct ",",Akt
R10399 T13491 T13489 conj NFκB,Akt
R10400 T13492 T13491 punct ",",NFκB
R10401 T13493 T13491 cc and,NFκB
R10402 T13494 T13491 conj Stat3,NFκB
R10403 T13495 T13494 cc but,Stat3
R10404 T13496 T13497 neg not,MAPK
R10405 T13497 T13494 conj MAPK,Stat3
R10406 T13498 T13487 conj pathways,activation
R10432 T13524 T13525 amod transgenic,lymphocytes
R10433 T13525 T13522 pobj lymphocytes,of
R10434 T13526 T13525 cc or,lymphocytes
R10435 T13527 T13528 compound lymphoma,cells
R10436 T13528 T13525 conj cells,lymphocytes
R10437 T13529 T13519 punct ",",affect
R10438 T13530 T13519 advcl confirming,affect
R10439 T13531 T13535 mark that,targeted
R10440 T13532 T13535 nsubjpass mTOR,targeted
R10441 T13533 T13535 auxpass is,targeted
R10442 T13534 T13535 neg not,targeted
R10443 T13535 T13530 ccomp targeted,confirming
R10444 T13536 T13535 agent by,targeted
R10445 T13537 T13538 compound Akt,activation
R10446 T13538 T13536 pobj activation,by
R10447 T13539 T13535 prep in,targeted
R10448 T13540 T13542 nummod LMP1,lymphocytes
R10449 T13541 T13542 amod transgenic,lymphocytes
R10450 T13542 T13539 pobj lymphocytes,in
R10451 T13543 T13542 cc or,lymphocytes
R10452 T13544 T13546 amod malignant,cells
R10453 T13545 T13546 compound lymphoma,cells
R10454 T13546 T13542 conj cells,lymphocytes
R10455 T13547 T13548 punct (,Figure
R10456 T13548 T13542 appos Figure,lymphocytes
R10457 T13549 T13548 nummod 7,Figure
R10458 T13550 T13548 punct ),Figure
R10459 T13551 T13519 punct .,affect
R19380 T24974 T24982 nsubjpass Akt,Required
R19381 T24975 T24974 punct ",",Akt
R19382 T24976 T24974 conj NFκB,Akt
R19383 T24977 T24976 punct ",",NFκB
R19384 T24978 T24976 cc and,NFκB
R19385 T24979 T24976 conj Stat3,NFκB
R19386 T24980 T24976 conj Signaling,NFκB
R19387 T24981 T24982 auxpass Are,Required
R19388 T24982 T24982 ROOT Required,Required
R19389 T24983 T24982 prep for,Required
R19390 T24984 T24992 det the,assay
R19391 T24985 T24992 nmod Growth,assay
R19392 T24986 T24985 cc and,Growth
R19393 T24987 T24985 conj Survival,Growth
R19394 T24988 T24985 prep of,Growth
R19395 T24989 T24991 compound Lymphoma,MTS
R19396 T24990 T24991 compound Cells,MTS
R19397 T24991 T24992 compound MTS,assay
R19398 T24992 T24983 pobj assay,for
R19399 T24993 T24992 prep of,assay
R19400 T24994 T24993 pobj splenocytes,of
R19401 T24995 T24992 prep from,assay
R19402 T24996 T24997 punct (,A
R19403 T24997 T24995 pobj A,from
R19404 T24998 T24997 cc and,A
R19405 T24999 T25001 nmod B,WT
R19406 T25000 T25001 punct ),WT
R19407 T25001 T25010 nmod WT,lymphomas
R19408 T25002 T25001 cc or,WT
R19409 T25003 T25001 punct (,WT
R19410 T25004 T25001 conj C,WT
R19411 T25005 T25004 cc and,C
R19412 T25006 T25004 conj D,C
R19413 T25007 T25004 punct ),C
R19414 T25008 T25010 nummod LMP1,lymphomas
R19415 T25009 T25010 amod transgenic,lymphomas
R19416 T25010 T24997 conj lymphomas,A
R19417 T25011 T25010 cc and,lymphomas
R19418 T25012 T25010 punct (,lymphomas
R19419 T25013 T25019 nmod E,lymphoctyes
R19420 T25014 T25013 cc and,E
R19421 T25015 T25013 conj F,E
R19422 T25016 T25013 punct ),E
R19423 T25017 T25019 nummod LMP1,lymphoctyes
R19424 T25018 T25019 amod transgenic,lymphoctyes
R19425 T25019 T25010 appos lymphoctyes,lymphomas
R19426 T25020 T25010 punct .,lymphomas
R19427 T25021 T25023 nsubjpass Splenocytes,cultured
R19428 T25022 T25023 auxpass were,cultured
R19429 T25023 T25023 ROOT cultured,cultured
R19430 T25024 T25023 prep with,cultured
R19431 T25025 T25024 cc or,with
R19432 T25026 T25024 conj without,with
R19433 T25027 T25026 pobj inhibitors,without
R19434 T25028 T25027 prep of,inhibitors
R19435 T25029 T25028 pobj NFκB,of
R19436 T25030 T25029 punct (,NFκB
R19437 T25031 T25029 appos BAY11,NFκB
R19438 T25032 T25029 punct ),NFκB
R19439 T25033 T25029 punct ",",NFκB
R19440 T25034 T25057 nmod mTOR,cucurbitacin
R19441 T25035 T25036 punct (,rapamycin
R19442 T25036 T25034 appos rapamycin,mTOR
R19443 T25037 T25036 punct ),rapamycin
R19444 T25038 T25034 punct ",",mTOR
R19445 T25039 T25034 conj Akt,mTOR
R19446 T25040 T25041 punct (,triciribine
R19447 T25041 T25039 appos triciribine,Akt
R19448 T25042 T25041 punct ),triciribine
R19449 T25043 T25039 punct ",",Akt
R19450 T25044 T25039 conj MEK1/2,Akt
R19451 T25045 T25046 punct (,U0126
R19452 T25046 T25044 appos U0126,MEK1/2
R19453 T25047 T25044 punct ),MEK1/2
R19454 T25048 T25044 punct ",",MEK1/2
R19455 T25049 T25057 nmod p38,cucurbitacin
R19456 T25050 T25049 punct (,p38
R19457 T25051 T25049 appos SB202190,p38
R19458 T25052 T25049 punct ),p38
R19459 T25053 T25049 punct ",",p38
R19460 T25054 T25049 cc or,p38
R19461 T25055 T25049 conj Stat3,p38
R19462 T25056 T25057 punct (,cucurbitacin
R19463 T25057 T25023 npadvmod cucurbitacin,cultured
R19464 T25058 T25060 nsubj I,AG490
R19465 T25059 T25058 cc and,I
R19466 T25060 T25057 appos AG490,cucurbitacin
R19467 T25061 T25060 punct ),AG490
R19468 T25062 T25057 prep at,cucurbitacin
R19469 T25063 T25065 det the,concentrations
R19470 T25064 T25065 amod indicated,concentrations
R19471 T25065 T25062 pobj concentrations,at
R19472 T25066 T25023 punct .,cultured
R19473 T25067 T25068 det The,results
R19474 T25068 T25069 nsubj results,are
R19475 T25069 T25069 ROOT are,are
R19476 T25070 T25073 det the,SEM
R19477 T25071 T25073 amod mean,SEM
R19478 T25072 T25073 compound ±,SEM
R19479 T25073 T25069 attr SEM,are
R19480 T25074 T25073 prep of,SEM
R19481 T25075 T25076 compound triplicate,samples
R19482 T25076 T25074 pobj samples,of
R19483 T25077 T25069 punct .,are
R19484 T25078 T25078 ROOT Shown,Shown
R19485 T25079 T25078 auxpass are,Shown
R19486 T25080 T25081 det the,results
R19487 T25081 T25078 nsubjpass results,Shown
R19488 T25082 T25081 prep for,results
R19489 T25083 T25084 punct (,A
R19490 T25084 T25082 pobj A,for
R19491 T25085 T25084 cc and,A
R19492 T25086 T25084 conj B,A
R19493 T25087 T25086 punct ),B
R19494 T25088 T25089 compound WT,lymphoma
R19495 T25089 T25115 nsubj lymphoma,analyzed
R19496 T25090 T25089 nummod 1,lymphoma
R19497 T25091 T25089 punct ",",lymphoma
R19498 T25092 T25093 punct (,C
R19499 T25093 T25089 appos C,lymphoma
R19500 T25094 T25093 cc and,C
R19501 T25095 T25093 conj D,C
R19502 T25096 T25093 punct ),C
R19503 T25097 T25093 appos LMP1,C
R19504 T25098 T25099 amod transgenic,lymphoma
R19505 T25099 T25097 pobj lymphoma,LMP1
R19506 T25100 T25099 nummod 2,lymphoma
R19507 T25101 T25093 punct ",",C
R19508 T25102 T25089 cc and,lymphoma
R19509 T25103 T25104 punct (,E
R19510 T25104 T25104 ROOT E,E
R19511 T25105 T25104 cc and,E
R19512 T25106 T25104 conj F,E
R19513 T25107 T25106 punct ),F
R19514 T25108 T25115 nsubj one,analyzed
R19515 T25109 T25108 prep out,one
R19516 T25110 T25109 prep of,out
R19517 T25111 T25114 nummod two,mice
R19518 T25112 T25114 nummod LMP1,mice
R19519 T25113 T25114 amod transgenic,mice
R19520 T25114 T25110 pobj mice,of
R19521 T25115 T25115 ROOT analyzed,analyzed
R19522 T25116 T25115 punct .,analyzed
R19523 T25117 T25118 det This,analysis
R19524 T25118 T25120 nsubjpass analysis,repeated
R19525 T25119 T25120 auxpass was,repeated
R19526 T25120 T25120 ROOT repeated,repeated
R19527 T25121 T25120 prep with,repeated
R19528 T25122 T25126 nsubj LMP1,yielding
R19529 T25123 T25124 amod transgenic,lymphoma
R19530 T25124 T25126 dep lymphoma,yielding
R19531 T25125 T25124 nummod 4,lymphoma
R19532 T25126 T25121 pcomp yielding,with
R19533 T25127 T25128 amod similar,results
R19534 T25128 T25126 dobj results,yielding
R19535 T25129 T25120 punct .,repeated
R19657 T25354 T25354 ROOT Analysis,Analysis
R19658 T25355 T25354 prep of,Analysis
R19659 T25356 T25355 pobj Akt,of
R19660 T25357 T25356 punct ",",Akt
R19661 T25358 T25356 conj NFκB,Akt
R19662 T25359 T25358 punct ",",NFκB
R19663 T25360 T25358 cc and,NFκB
R19664 T25361 T25362 compound Stat3,Pathways
R19665 T25362 T25358 conj Pathways,NFκB
R19666 T25363 T25354 prep in,Analysis
R19667 T25364 T25363 pobj Contribution,in
R19668 T25365 T25364 prep to,Contribution
R19669 T25366 T25367 det the,Growth
R19670 T25367 T25365 pobj Growth,to
R19671 T25368 T25367 cc and,Growth
R19672 T25369 T25367 conj Survival,Growth
R19673 T25370 T25367 prep of,Growth
R19674 T25371 T25372 compound Lymphoma,Cells
R19675 T25372 T25370 pobj Cells,of
R19676 T25373 T25374 punct (,A
R19677 T25374 T25367 appos A,Growth
R19678 T25375 T25378 poss D,analysis
R19679 T25376 T25375 punct ),D
R19680 T25377 T25378 compound Immunoblot,analysis
R19681 T25378 T25391 dative analysis,Stat3
R19682 T25379 T25378 prep of,analysis
R19683 T25380 T25384 nmod wild-type,lymphomas
R19684 T25381 T25380 cc and,wild-type
R19685 T25382 T25380 conj LMP1,wild-type
R19686 T25383 T25384 amod transgenic,lymphomas
R19687 T25384 T25379 pobj lymphomas,of
R19688 T25385 T25378 prep for,analysis
R19689 T25386 T25385 pobj Akt,for
R19690 T25387 T25386 punct ",",Akt
R19691 T25388 T25386 conj NFκB,Akt
R19692 T25389 T25388 punct ",",NFκB
R19693 T25390 T25388 cc and,NFκB
R19694 T25391 T25367 appos Stat3,Growth
R19695 T25392 T25391 acl signaling,Stat3
R19696 T25393 T25392 prep after,signaling
R19697 T25394 T25393 pobj treatment,after
R19698 T25395 T25394 prep with,treatment
R19699 T25396 T25397 punct (,A
R19700 T25397 T25395 pobj A,with
R19701 T25398 T25397 punct ),A
R19702 T25399 T25401 det an,inhibitor
R19703 T25400 T25401 compound Akt,inhibitor
R19704 T25401 T25394 conj inhibitor,treatment
R19705 T25402 T25401 punct ",",inhibitor
R19706 T25403 T25401 conj triciribine,inhibitor
R19707 T25404 T25392 punct ",",signaling
R19708 T25405 T25406 punct (,B
R19709 T25406 T25392 appos B,signaling
R19710 T25407 T25406 punct ),B
R19711 T25408 T25410 det an,inhibitor
R19712 T25409 T25410 compound NFκB,inhibitor
R19713 T25410 T25392 dobj inhibitor,signaling
R19714 T25411 T25410 punct ",",inhibitor
R19715 T25412 T25410 appos BAY11,inhibitor
R19716 T25413 T25410 appos 7085,inhibitor
R19717 T25414 T25410 punct ",",inhibitor
R19718 T25415 T25410 cc and,inhibitor
R19719 T25416 T25418 det the,inhibitors
R19720 T25417 T25418 amod Stat3,inhibitors
R19721 T25418 T25410 conj inhibitors,inhibitor
R19722 T25419 T25418 punct (,inhibitors
R19723 T25420 T25418 appos C,inhibitors
R19724 T25421 T25418 punct ),inhibitors
R19725 T25422 T25428 nmod cucurbitacin,AG490
R19726 T25423 T25428 nmod I,AG490
R19727 T25424 T25423 cc and,I
R19728 T25425 T25426 punct (,D
R19729 T25426 T25428 nmod D,AG490
R19730 T25427 T25428 punct ),AG490
R19731 T25428 T25410 appos AG490,inhibitor
R19732 T25429 T25410 punct ",",inhibitor
R19733 T25430 T25410 prep at,inhibitor
R19734 T25431 T25433 det the,concentrations
R19735 T25432 T25433 amod indicated,concentrations
R19736 T25433 T25430 pobj concentrations,at
R19737 T25434 T25354 punct .,Analysis
R19738 T25435 T25436 nsubj Arrows,indicate
R19739 T25436 T25436 ROOT indicate,indicate
R19740 T25437 T25438 det the,positions
R19741 T25438 T25436 dobj positions,indicate
R19742 T25439 T25438 prep of,positions
R19743 T25440 T25439 pobj α,of
R19744 T25441 T25440 cc and,α
R19745 T25442 T25440 conj β,α
R19746 T25443 T25438 conj isoforms,positions
R19747 T25444 T25438 prep of,positions
R19748 T25445 T25444 pobj Stat3,of
R19749 T25446 T25436 punct .,indicate
R19750 T25447 T25449 nsubjpass Actin,used
R19751 T25448 T25449 auxpass was,used
R19752 T25449 T25449 ROOT used,used
R19753 T25450 T25449 prep as,used
R19754 T25451 T25453 det a,control
R19755 T25452 T25453 compound loading,control
R19756 T25453 T25450 pobj control,as
R19757 T25454 T25449 punct .,used
R10016 T13108 T13109 nsubj This,is
R10017 T13109 T13109 ROOT is,is
R10018 T13110 T13111 advmod well,within
R10019 T13111 T13109 prep within,is
R10020 T13112 T13114 det the,IC50
R10021 T13113 T13114 amod reported,IC50
R10022 T13114 T13111 pobj IC50,within
R10023 T13115 T13114 prep of,IC50
R10024 T13116 T13117 nummod 10,μM
R10025 T13117 T13115 pobj μM,of
R10026 T13118 T13109 punct .,is
R10027 T13119 T13120 compound Phosphorylated,Akt
R10028 T13120 T13127 nsubj Akt,were
R10029 T13121 T13120 punct ",",Akt
R10030 T13122 T13120 conj Stat3,Akt
R10031 T13123 T13122 punct ",",Stat3
R10032 T13124 T13122 cc and,Stat3
R10033 T13125 T13126 amod total,IκBα
R10034 T13126 T13122 conj IκBα,Stat3
R10035 T13127 T13127 ROOT were,were
R10036 T13128 T13127 advmod still,were
R10037 T13129 T13127 acomp present,were
R10038 T13130 T13129 prt up,present
R10172 T13264 T13265 amod higher,doses
R10173 T13265 T13263 pobj doses,at
R10174 T13266 T13268 det all,levels
R10175 T13267 T13268 compound protein,levels
R10176 T13268 T13271 nsubjpass levels,decreased
R10177 T13269 T13271 auxpass were,decreased
R10178 T13270 T13271 advmod greatly,decreased
R10179 T13271 T13256 conj decreased,were
R10180 T13272 T13271 punct ",",decreased
R10181 T13273 T13271 advcl indicative,decreased
R10182 T13274 T13273 prep of,indicative
R10183 T13275 T13277 det the,loss
R10184 T13276 T13277 amod total,loss
R10185 T13277 T13274 pobj loss,of
R10186 T13278 T13277 prep of,loss
R10187 T13279 T13278 pobj viability,of
R10188 T13280 T13281 punct (,Figure
R10189 T13281 T13277 appos Figure,loss
R10190 T13282 T13281 nummod 8,Figure
R10191 T13283 T13281 punct ),Figure
R10192 T13284 T13271 punct .,decreased
R10193 T13285 T13287 det A,reported
R10228 T13320 T13318 parataxis Figure,affected
R10229 T13321 T13320 nummod 8,Figure
R10230 T13322 T13320 punct ),Figure
R10231 T13323 T13315 punct .,were
R10232 T13324 T13325 det These,findings
R10233 T13325 T13326 nsubj findings,suggest
R10234 T13326 T13326 ROOT suggest,suggest
R10235 T13327 T13332 mark that,induce
R10236 T13328 T13332 nsubj inhibition,induce
R10237 T13329 T13328 prep of,inhibition
R10238 T13330 T13329 pobj Stat3,of
R10239 T13331 T13332 aux can,induce
R10240 T13332 T13326 ccomp induce,suggest
R10241 T13333 T13334 compound cell,death
R10242 T13334 T13332 dobj death,induce
R10243 T13335 T13332 prep in,induce
R10244 T13336 T13338 nummod LMP1,lymphocytes
R10245 T13337 T13338 amod transgenic,lymphocytes
R10246 T13338 T13335 pobj lymphocytes,in
R10247 T13339 T13338 cc and,lymphocytes
R10248 T13340 T13341 compound lymphoma,cells
R10250 T13342 T13332 punct ",",induce
R10251 T13343 T13326 cc but,suggest
R10252 T13344 T13345 amod Stat3,inhibition
R10253 T13345 T13347 nsubj inhibition,has
R10254 T13346 T13347 advmod also,has
R10255 T13347 T13326 conj has,suggest
R10256 T13348 T13350 amod considerable,effects
R10257 T13349 T13350 amod crossover,effects
R10258 T13350 T13347 dobj effects,has
R10259 T13351 T13350 prep on,effects
R10260 T13352 T13351 pobj Akt,on
R10261 T13353 T13352 cc and,Akt
R10262 T13354 T13352 conj NFκB,Akt
R10263 T13355 T13350 acl signaling,effects
R10264 T13356 T13347 punct .,has
R10265 T13357 T13361 nsubjpass LMP1,shown
R10266 T13358 T13361 aux has,shown
R10267 T13359 T13361 advmod also,shown
R10268 T13360 T13361 auxpass been,shown
R10269 T13361 T13361 ROOT shown,shown
R10270 T13362 T13363 aux to,activate
R10271 T13363 T13361 xcomp activate,shown
R10272 T13364 T13363 dobj JNK,activate
R10306 T13398 T13397 prep of,inhibitor
R10307 T13399 T13400 compound MEK1/2,activity
R10308 T13400 T13398 pobj activity,of
R10309 T13401 T13377 punct .,were
R10310 T13402 T13407 advmod However,were
R10311 T13403 T13407 punct ",",were
R10312 T13404 T13407 nsubj effects,were
R10313 T13405 T13404 prep of,effects
R10314 T13406 T13405 pobj SB202190,of
R10315 T13407 T13407 ROOT were,were
R10316 T13408 T13409 advmod only,apparent
R10317 T13409 T13407 acomp apparent,were
R10318 T13410 T13409 prep at,apparent
R10319 T13411 T13412 amod high,doses
R10320 T13412 T13410 pobj doses,at
R10321 T13413 T13412 punct (,doses
R10322 T13414 T13412 appos >,doses
R10323 T13415 T13416 nummod 10,μM
R10324 T13416 T13414 nmod μM,>
R10325 T13417 T13412 punct ),doses
R10326 T13418 T13407 punct ",",were
R10327 T13419 T13420 advmod much,higher
R10407 T13499 T13485 ccomp are,suggesting
R10408 T13500 T13499 attr characteristics,are
R10409 T13501 T13500 acl associated,characteristics
R10410 T13502 T13501 prep with,associated
R10411 T13503 T13504 amod malignant,transformation
R10412 T13504 T13502 pobj transformation,with
R10413 T13505 T13506 punct (,Figure
R10414 T13506 T13504 appos Figure,transformation
R10415 T13507 T13506 nummod 7,Figure
R10416 T13508 T13506 punct ),Figure
R10417 T13509 T13461 punct .,were
R10418 T13510 T13519 nsubj rapamycin,affect
R10419 T13511 T13510 punct ",",rapamycin
R10420 T13512 T13513 det an,inhibitor
R10421 T13513 T13510 appos inhibitor,rapamycin
R10422 T13514 T13513 prep of,inhibitor
R10423 T13515 T13514 pobj mTOR,of
R10424 T13516 T13519 punct ",",affect
R10425 T13517 T13519 aux did,affect
R10426 T13518 T13519 neg not,affect
R10427 T13519 T13519 ROOT affect,affect
R10428 T13520 T13521 det the,viability
R10429 T13521 T13519 dobj viability,affect
R10430 T13522 T13521 prep of,viability
R10431 T13523 T13525 det the,lymphocytes

GO-BP

Id Subject Object Predicate Lexical cue
T11867 20-26 http://purl.obolibrary.org/obo/GO_0040007 denotes Growth
T11868 149-155 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11869 344-350 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11870 817-823 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11871 915-921 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11872 1063-1069 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11873 3653-3659 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11874 4166-4172 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11875 4608-4614 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11876 323-327 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T11877 4526-4530 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T11878 4659-4663 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T11879 4852-4856 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T11880 4522-4525 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T11881 4655-4658 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T11882 4848-4851 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T11883 910-921 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T11884 1302-1317 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T11885 2859-2868 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11886 2969-2978 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11887 4466-4475 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11888 2885-2895 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T11889 3394-3404 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T11890 4327-4337 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T11891 2890-2895 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T11892 3399-3404 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T11893 4332-4337 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T11894 4514-4517 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T11895 4608-4625 http://purl.obolibrary.org/obo/GO_0045926 denotes growth inhibition
T11896 4696-4700 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T24800 1682-1688 http://purl.obolibrary.org/obo/GO_0040007 denotes Growth
T24801 1952-1956 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T24802 1968-1971 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T24803 2193-2202 http://purl.obolibrary.org/obo/GO_0010309 denotes 2, and (E
T25242 2416-2422 http://purl.obolibrary.org/obo/GO_0040007 denotes Growth
T25243 2548-2557 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

GO-MF

Id Subject Object Predicate Lexical cue
T13576 323-327 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T13577 4526-4530 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T13578 4659-4663 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T13579 4852-4856 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T13580 4522-4525 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T13581 4655-4658 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T13582 4848-4851 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T13583 4514-4517 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13584 4696-4700 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T25136 1952-1956 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T25137 1968-1971 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T25138 2193-2202 http://purl.obolibrary.org/obo/GO_0010309 denotes 2, and (E

GO-CC

Id Subject Object Predicate Lexical cue
T13585 841-846 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13586 1114-1119 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13587 1613-1618 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13588 3065-3070 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13589 3112-3117 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13590 3449-3454 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13591 3764-3769 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13592 4382-4387 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13593 4960-4965 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13594 5419-5424 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13595 5534-5539 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T11843 0-91 Sentence denotes LMP1 Promotes Tumor Growth and Survival through Activation of Akt, NFκB, and Stat3 Pathways
T11844 92-381 Sentence denotes To explore which pathways were required for the enhanced growth and survival of LMP1-induced lymphomas, splenocytes from wild-type and LMP1 transgenic mice were cultured in the presence of inhibitors for Akt, NFκB, Stat3, mTOR, or MAPK and assayed for growth and survival by the MTS assay.
T11845 382-496 Sentence denotes As previously shown, wild-type lymphocytes were not viable in culture and could not be tested with the inhibitors.
T11846 497-735 Sentence denotes However, the enhanced viability of LMP1 transgenic lymphocytes was effectively blocked by treatment with triciribine, BAY11–7085, cucurbitacin I, and slightly with SB203580, but not by treatment with rapamycin, U0126, or AG490 (Figure 7).
T11847 736-879 Sentence denotes Triciribine inhibits the activation of Akt and at 20 μM has been shown to induce growth arrest in cancer cells with aberrant Akt activity [46].
T11848 880-1131 Sentence denotes The effects of triciribine on cell growth of the transgenic lymphocytes and lymphomas were apparent as low as 1 μM, suggesting that activation of Akt is required for the survival and growth of LMP1 transgenic lymphocytes and lymphoma cells (Figure 7).
T11849 1132-1254 Sentence denotes The effects of the inhibitors were assessed by identifying phosphorylated Akt, Stat3, and total levels of IκBα (Figure 8).
T11850 1255-1382 Sentence denotes Treatment with triciribine effectively blocked phosphorylation of Akt, and phosphorylated Akt was no longer detected past 5 μM.
T11851 1383-1441 Sentence denotes Phosphorylated Stat3 and IκBα were still present at 25 μM.
T11852 1442-1619 Sentence denotes These findings suggest that triciribine specifically targets Akt and that Akt activation is required for the enhanced viability of the transgenic lymphocytes and lymphoma cells.
T11853 2840-2935 Sentence denotes Inhibition of NFκB signaling rapidly induces cell death of EBV-transformed lymphocytes [17,18].
T11854 2936-3155 Sentence denotes BAY11–7085, an inhibitor of NFκB signaling, also greatly decreased the viability of the LMP1 transgenic lymphocytes and lymphoma cells at doses as low as 1 μM, and at 5 μM the cells were completely nonviable (Figure 7).
T11855 3156-3203 Sentence denotes This is well within the reported IC50 of 10 μM.
T11856 3204-3336 Sentence denotes Phosphorylated Akt, Stat3, and total IκBα were still present up to treatment with 15 μM and then were no longer detected (Figure 8).
T11857 3337-3513 Sentence denotes This finding suggests that inhibition of NFκB can induce cell death in LMP1 transgenic lymphocytes and lymphoma cells without significant effects on activation of Akt or Stat3.
T11858 3514-3607 Sentence denotes Cucurbitacin I inhibits activation of Stat3 by suppressing the activation of its kinase JAK2.
T11859 3608-3711 Sentence denotes It has been shown to selectively inhibit the growth of tumors with constitutively activated Stat3 [47].
T11860 3712-3914 Sentence denotes Similarly, LMP1 transgenic lymphocytes and lymphoma cells were susceptible to cucurbitacin I treatment starting at 0.1 μM, a dose that corresponds closely to the reported IC50 of 500 nM (Figure 7) [47].
T11861 3915-4103 Sentence denotes Phosphorylated Akt, Stat3, and total IκBα were not detectable past 1 μM and at higher doses all protein levels were greatly decreased, indicative of the total loss of viability (Figure 8).
T11862 4104-4267 Sentence denotes A second reported inhibitor of Stat3, AG490, had no effect on growth (Figure 7), but activation of Akt, Stat3, or levels of IκBα were also not affected (Figure 8).
T11863 4268-4476 Sentence denotes These findings suggest that inhibition of Stat3 can induce cell death in LMP1 transgenic lymphocytes and lymphoma cells, but Stat3 inhibition also has considerable crossover effects on Akt and NFκB signaling.
T11864 4477-4712 Sentence denotes LMP1 has also been shown to activate JNK and p38 MAPK pathways [13,48], and LMP1 transgenic lymphocytes were mildly susceptible to growth inhibition by SB202190, an inhibitor of p38 MAPK, but not U0126, an inhibitor of MEK1/2 activity.
T11865 4713-4977 Sentence denotes However, effects of SB202190 were only apparent at high doses (>10 μM), much higher than the reported IC50 of 0.35 μM, suggesting that p38 MAPK does not significantly contribute to the enhanced viability in LMP1 transgenic lymphocytes or lymphoma cells (Figure 7).
T11866 4978-5551 Sentence denotes Interestingly, both wild-type and LMP1 transgenic lymphomas were similarly susceptible to triciribine, BAY11–7085, and cucurbitacin I treatments, but not SB202190, AG490, or U0126 treatment, suggesting that activation of Akt, NFκB, and Stat3 but not MAPK pathways are characteristics associated with malignant transformation (Figure 7). rapamycin, an inhibitor of mTOR, did not affect the viability of the transgenic lymphocytes or lymphoma cells, confirming that mTOR is not targeted by Akt activation in LMP1 transgenic lymphocytes or malignant lymphoma cells (Figure 7).
T24794 1630-1719 Sentence denotes Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells
T24795 1720-1844 Sentence denotes MTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes.
T24796 1845-2052 Sentence denotes Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations.
T24797 2053-2106 Sentence denotes The results are the mean ± SEM of triplicate samples.
T24798 2107-2255 Sentence denotes Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed.
T24799 2256-2340 Sentence denotes This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.
T25238 2351-2453 Sentence denotes Analysis of Akt, NFκB, and Stat3 Pathways in Contribution to the Growth and Survival of Lymphoma Cells
T25239 2454-2740 Sentence denotes (A–D) Immunoblot analysis of wild-type and LMP1 transgenic lymphomas for Akt, NFκB, and Stat3 signaling after treatment with (A) an Akt inhibitor, triciribine, (B) an NFκB inhibitor, BAY11–7085, and the Stat3 inhibitors (C) cucurbitacin I and (D) AG490, at the indicated concentrations.
T25240 2741-2800 Sentence denotes Arrows indicate the positions of α and β isoforms of Stat3.
T25241 2801-2837 Sentence denotes Actin was used as a loading control.
T199 0-91 Sentence denotes LMP1 Promotes Tumor Growth and Survival through Activation of Akt, NFκB, and Stat3 Pathways
T200 92-381 Sentence denotes To explore which pathways were required for the enhanced growth and survival of LMP1-induced lymphomas, splenocytes from wild-type and LMP1 transgenic mice were cultured in the presence of inhibitors for Akt, NFκB, Stat3, mTOR, or MAPK and assayed for growth and survival by the MTS assay.
T201 382-496 Sentence denotes As previously shown, wild-type lymphocytes were not viable in culture and could not be tested with the inhibitors.
T202 497-735 Sentence denotes However, the enhanced viability of LMP1 transgenic lymphocytes was effectively blocked by treatment with triciribine, BAY11–7085, cucurbitacin I, and slightly with SB203580, but not by treatment with rapamycin, U0126, or AG490 (Figure 7).
T203 736-879 Sentence denotes Triciribine inhibits the activation of Akt and at 20 μM has been shown to induce growth arrest in cancer cells with aberrant Akt activity [46].
T204 880-1131 Sentence denotes The effects of triciribine on cell growth of the transgenic lymphocytes and lymphomas were apparent as low as 1 μM, suggesting that activation of Akt is required for the survival and growth of LMP1 transgenic lymphocytes and lymphoma cells (Figure 7).
T205 1132-1254 Sentence denotes The effects of the inhibitors were assessed by identifying phosphorylated Akt, Stat3, and total levels of IκBα (Figure 8).
T206 1255-1382 Sentence denotes Treatment with triciribine effectively blocked phosphorylation of Akt, and phosphorylated Akt was no longer detected past 5 μM.
T207 1383-1441 Sentence denotes Phosphorylated Stat3 and IκBα were still present at 25 μM.
T208 1442-1619 Sentence denotes These findings suggest that triciribine specifically targets Akt and that Akt activation is required for the enhanced viability of the transgenic lymphocytes and lymphoma cells.
T209 1620-1719 Sentence denotes Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells
T210 1720-1844 Sentence denotes MTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes.
T211 1845-2052 Sentence denotes Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations.
T212 2053-2106 Sentence denotes The results are the mean ± SEM of triplicate samples.
T213 2107-2255 Sentence denotes Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed.
T214 2256-2340 Sentence denotes This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.
T215 2341-2453 Sentence denotes Figure 8 Analysis of Akt, NFκB, and Stat3 Pathways in Contribution to the Growth and Survival of Lymphoma Cells
T216 2454-2740 Sentence denotes (A–D) Immunoblot analysis of wild-type and LMP1 transgenic lymphomas for Akt, NFκB, and Stat3 signaling after treatment with (A) an Akt inhibitor, triciribine, (B) an NFκB inhibitor, BAY11–7085, and the Stat3 inhibitors (C) cucurbitacin I and (D) AG490, at the indicated concentrations.
T217 2741-2800 Sentence denotes Arrows indicate the positions of α and β isoforms of Stat3.
T218 2801-2837 Sentence denotes Actin was used as a loading control.
T219 2840-2935 Sentence denotes Inhibition of NFκB signaling rapidly induces cell death of EBV-transformed lymphocytes [17,18].
T220 2936-3155 Sentence denotes BAY11–7085, an inhibitor of NFκB signaling, also greatly decreased the viability of the LMP1 transgenic lymphocytes and lymphoma cells at doses as low as 1 μM, and at 5 μM the cells were completely nonviable (Figure 7).
T221 3156-3203 Sentence denotes This is well within the reported IC50 of 10 μM.
T222 3204-3336 Sentence denotes Phosphorylated Akt, Stat3, and total IκBα were still present up to treatment with 15 μM and then were no longer detected (Figure 8).
T223 3337-3513 Sentence denotes This finding suggests that inhibition of NFκB can induce cell death in LMP1 transgenic lymphocytes and lymphoma cells without significant effects on activation of Akt or Stat3.
T224 3514-3607 Sentence denotes Cucurbitacin I inhibits activation of Stat3 by suppressing the activation of its kinase JAK2.
T225 3608-3711 Sentence denotes It has been shown to selectively inhibit the growth of tumors with constitutively activated Stat3 [47].
T226 3712-3914 Sentence denotes Similarly, LMP1 transgenic lymphocytes and lymphoma cells were susceptible to cucurbitacin I treatment starting at 0.1 μM, a dose that corresponds closely to the reported IC50 of 500 nM (Figure 7) [47].
T227 3915-4103 Sentence denotes Phosphorylated Akt, Stat3, and total IκBα were not detectable past 1 μM and at higher doses all protein levels were greatly decreased, indicative of the total loss of viability (Figure 8).
T228 4104-4267 Sentence denotes A second reported inhibitor of Stat3, AG490, had no effect on growth (Figure 7), but activation of Akt, Stat3, or levels of IκBα were also not affected (Figure 8).
T229 4268-4476 Sentence denotes These findings suggest that inhibition of Stat3 can induce cell death in LMP1 transgenic lymphocytes and lymphoma cells, but Stat3 inhibition also has considerable crossover effects on Akt and NFκB signaling.
T230 4477-4712 Sentence denotes LMP1 has also been shown to activate JNK and p38 MAPK pathways [13,48], and LMP1 transgenic lymphocytes were mildly susceptible to growth inhibition by SB202190, an inhibitor of p38 MAPK, but not U0126, an inhibitor of MEK1/2 activity.
T231 4713-4977 Sentence denotes However, effects of SB202190 were only apparent at high doses (>10 μM), much higher than the reported IC50 of 0.35 μM, suggesting that p38 MAPK does not significantly contribute to the enhanced viability in LMP1 transgenic lymphocytes or lymphoma cells (Figure 7).
T232 4978-5551 Sentence denotes Interestingly, both wild-type and LMP1 transgenic lymphomas were similarly susceptible to triciribine, BAY11–7085, and cucurbitacin I treatments, but not SB202190, AG490, or U0126 treatment, suggesting that activation of Akt, NFκB, and Stat3 but not MAPK pathways are characteristics associated with malignant transformation (Figure 7). rapamycin, an inhibitor of mTOR, did not affect the viability of the transgenic lymphocytes or lymphoma cells, confirming that mTOR is not targeted by Akt activation in LMP1 transgenic lymphocytes or malignant lymphoma cells (Figure 7).

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T13929 0-4 Protein denotes LMP1
T13930 62-65 Protein denotes Akt
T13931 77-82 Protein denotes Stat3
T13932 172-176 Protein denotes LMP1
T13933 227-231 Protein denotes LMP1
T13934 281-291 Negative_regulation denotes inhibitors
T13935 281-291 Negative_regulation denotes inhibitors
T13936 281-291 Negative_regulation denotes inhibitors
T13937 296-299 Protein denotes Akt
T13938 307-312 Protein denotes Stat3
T13939 314-318 Protein denotes mTOR
T13940 532-536 Protein denotes LMP1
T13941 748-756 Negative_regulation denotes inhibits
T13942 761-771 Positive_regulation denotes activation
T13943 775-778 Protein denotes Akt
T13944 861-864 Protein denotes Akt
T13945 1012-1022 Positive_regulation denotes activation
T13946 1026-1029 Protein denotes Akt
T13947 1073-1077 Protein denotes LMP1
T13948 1191-1205 Phosphorylation denotes phosphorylated
T13949 1191-1205 Phosphorylation denotes phosphorylated
T13950 1206-1209 Protein denotes Akt
T13951 1211-1216 Protein denotes Stat3
T13952 1238-1242 Protein denotes IκBα
T13953 1294-1301 Negative_regulation denotes blocked
T13954 1302-1317 Phosphorylation denotes phosphorylation
T13955 1321-1324 Protein denotes Akt
T13956 1330-1344 Phosphorylation denotes phosphorylated
T13957 1345-1348 Protein denotes Akt
T13958 1363-1371 Positive_regulation denotes detected true
T13959 1383-1397 Phosphorylation denotes Phosphorylated
T13960 1383-1397 Phosphorylation denotes Phosphorylated
T13961 1398-1403 Protein denotes Stat3
T13962 1408-1412 Protein denotes IκBα
T13963 1495-1502 Regulation denotes targets true
T13964 1503-1506 Protein denotes Akt
T13965 1516-1519 Protein denotes Akt
T13966 1520-1530 Positive_regulation denotes activation
T13967 3024-3028 Protein denotes LMP1
T13968 3204-3218 Phosphorylation denotes Phosphorylated
T13969 3204-3218 Phosphorylation denotes Phosphorylated
T13970 3219-3222 Protein denotes Akt
T13971 3224-3229 Protein denotes Stat3
T13972 3241-3245 Protein denotes IκBα
T13973 3257-3264 Positive_regulation denotes present
T13974 3257-3264 Positive_regulation denotes present
T13975 3257-3264 Positive_regulation denotes present
T13976 3316-3324 Positive_regulation denotes detected true
T13977 3316-3324 Positive_regulation denotes detected true
T13978 3316-3324 Positive_regulation denotes detected true
T13979 3408-3412 Protein denotes LMP1
T13980 3475-3482 Regulation denotes effects true true
T13981 3475-3482 Regulation denotes effects true true
T13982 3486-3496 Positive_regulation denotes activation
T13983 3486-3496 Positive_regulation denotes activation
T13984 3500-3503 Protein denotes Akt
T13985 3507-3512 Protein denotes Stat3
T13986 3529-3537 Negative_regulation denotes inhibits
T13987 3538-3548 Positive_regulation denotes activation
T13988 3552-3557 Protein denotes Stat3
T13989 3602-3606 Protein denotes JAK2
T13990 3690-3699 Positive_regulation denotes activated
T13991 3700-3705 Protein denotes Stat3
T13992 3723-3727 Protein denotes LMP1
T13993 3915-3929 Phosphorylation denotes Phosphorylated
T13994 3915-3929 Phosphorylation denotes Phosphorylated
T13995 3930-3933 Protein denotes Akt
T13996 3935-3940 Protein denotes Stat3
T13997 3952-3956 Protein denotes IκBα
T13998 3966-3976 Positive_regulation denotes detectable true
T13999 3966-3976 Positive_regulation denotes detectable true
T14000 3966-3976 Positive_regulation denotes detectable true
T14001 4039-4048 Negative_regulation denotes decreased
T14002 4039-4048 Negative_regulation denotes decreased
T14003 4039-4048 Negative_regulation denotes decreased
T14004 4122-4131 Negative_regulation denotes inhibitor
T14005 4135-4140 Protein denotes Stat3
T14006 4203-4206 Protein denotes Akt
T14007 4208-4213 Protein denotes Stat3
T14008 4228-4232 Protein denotes IκBα
T14009 4247-4255 Regulation denotes affected true
T14010 4296-4306 Negative_regulation denotes inhibition
T14011 4310-4315 Protein denotes Stat3
T14012 4341-4345 Protein denotes LMP1
T14013 4393-4398 Protein denotes Stat3
T14014 4399-4409 Negative_regulation denotes inhibition
T14015 4453-4456 Protein denotes Akt
T14016 4477-4481 Protein denotes LMP1
T14017 4553-4557 Protein denotes LMP1
T14018 4683-4692 Negative_regulation denotes inhibitor
T14019 4683-4692 Negative_regulation denotes inhibitor
T14020 4696-4700 Protein denotes MEK1
T14021 4701-4702 Protein denotes 2
T14022 4920-4924 Protein denotes LMP1
T14023 5012-5016 Protein denotes LMP1
T14024 5199-5202 Protein denotes Akt
T14025 5214-5219 Protein denotes Stat3
T14026 5329-5338 Negative_regulation denotes inhibitor
T14027 5342-5346 Protein denotes mTOR
T14028 5442-5446 Protein denotes mTOR
T14029 5454-5462 Regulation denotes targeted true
T14030 5466-5469 Protein denotes Akt
T14031 5484-5488 Protein denotes LMP1
T25191 1630-1633 Protein denotes Akt
T25192 1645-1650 Protein denotes Stat3
T25193 1776-1780 Protein denotes LMP1
T25194 1816-1820 Protein denotes LMP1
T25195 1887-1897 Negative_regulation denotes inhibitors
T25196 1887-1897 Negative_regulation denotes inhibitors
T25197 1887-1897 Negative_regulation denotes inhibitors
T25198 1887-1897 Negative_regulation denotes inhibitors
T25199 1887-1897 Negative_regulation denotes inhibitors
T25200 1915-1919 Protein denotes mTOR
T25201 1933-1936 Protein denotes Akt
T25202 1952-1956 Protein denotes MEK1
T25203 1957-1958 Protein denotes 2
T25204 1987-1992 Protein denotes Stat3
T25205 2168-2172 Protein denotes LMP1
T25206 2225-2229 Protein denotes LMP1
T25207 2288-2292 Protein denotes LMP1
T25494 2363-2366 Protein denotes Akt
T25495 2378-2383 Protein denotes Stat3
T25496 2497-2501 Protein denotes LMP1
T25497 2527-2530 Protein denotes Akt
T25498 2542-2547 Protein denotes Stat3
T25499 2586-2589 Protein denotes Akt
T25500 2590-2599 Negative_regulation denotes inhibitor
T25501 2657-2662 Protein denotes Stat3
T25502 2663-2673 Negative_regulation denotes inhibitors
T25503 2794-2799 Protein denotes Stat3
R10614 T13937 T13935 themeOf Akt,inhibitors
R10621 T13938 T13936 themeOf Stat3,inhibitors
R10622 T13939 T13934 themeOf mTOR,inhibitors
R10623 T13942 T13941 themeOf activation,inhibits
R10624 T13943 T13942 themeOf Akt,activation
R10625 T13946 T13945 themeOf Akt,activation
R10626 T13950 T13948 themeOf Akt,phosphorylated
R10627 T13951 T13949 themeOf Stat3,phosphorylated
R10628 T13954 T13953 themeOf phosphorylation,blocked
R10629 T13955 T13954 themeOf Akt,phosphorylation
R10630 T13956 T13958 themeOf phosphorylated,detected
R10631 T13957 T13956 themeOf Akt,phosphorylated
R10632 T13961 T13960 themeOf Stat3,Phosphorylated
R10633 T13962 T13959 themeOf IκBα,Phosphorylated
R10634 T13964 T13963 themeOf Akt,targets
R10635 T13965 T13966 themeOf Akt,activation
R10636 T13968 T13974 themeOf Phosphorylated,present
R10637 T13968 T13977 themeOf Phosphorylated,detected
R10638 T13969 T13973 themeOf Phosphorylated,present
R10639 T13969 T13978 themeOf Phosphorylated,detected
R10640 T13970 T13969 themeOf Akt,Phosphorylated
R10641 T13971 T13968 themeOf Stat3,Phosphorylated
R10642 T13972 T13975 themeOf IκBα,present
R10643 T13972 T13976 themeOf IκBα,detected
R10644 T13982 T13981 themeOf activation,effects
R10645 T13983 T13980 themeOf activation,effects
R10646 T13984 T13983 themeOf Akt,activation
R10647 T13985 T13982 themeOf Stat3,activation
R10648 T13987 T13986 themeOf activation,inhibits
R10649 T13988 T13987 themeOf Stat3,activation
R10650 T13991 T13990 themeOf Stat3,activated
R10651 T13995 T13993 themeOf Akt,Phosphorylated
R10652 T13995 T13999 themeOf Akt,detectable
R10653 T13995 T14003 themeOf Akt,decreased
R10654 T13996 T13994 themeOf Stat3,Phosphorylated
R10655 T13996 T13998 themeOf Stat3,detectable
R10656 T13996 T14002 themeOf Stat3,decreased
R10657 T13997 T14000 themeOf IκBα,detectable
R10658 T13997 T14001 themeOf IκBα,decreased
R10659 T14005 T14004 themeOf Stat3,inhibitor
R10660 T14008 T14009 themeOf IκBα,affected
R10661 T14011 T14010 themeOf Stat3,inhibition
R10662 T14013 T14014 themeOf Stat3,inhibition
R10663 T14020 T14019 themeOf MEK1,inhibitor
R10664 T14021 T14018 themeOf 2,inhibitor
R10665 T14027 T14026 themeOf mTOR,inhibitor
R10666 T14028 T14029 themeOf mTOR,targeted
R19552 T25200 T25198 themeOf mTOR,inhibitors
R19553 T25201 T25197 themeOf Akt,inhibitors
R19554 T25202 T25196 themeOf MEK1,inhibitors
R19555 T25203 T25195 themeOf 2,inhibitors
R19556 T25204 T25199 themeOf Stat3,inhibitors
R19765 T25499 T25500 themeOf Akt,inhibitor
R19766 T25501 T25502 themeOf Stat3,inhibitors

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T13802 0-4 Protein denotes LMP1
T13803 62-65 Protein denotes Akt
T13804 67-71 Protein denotes NFκB
T13805 77-82 Protein denotes Stat3
T13806 48-58 Positive_regulation denotes Activation
T13807 48-58 Positive_regulation denotes Activation
T13808 48-58 Positive_regulation denotes Activation
T13809 172-176 Protein denotes LMP1
T13810 227-231 Protein denotes LMP1
T13811 296-299 Protein denotes Akt
T13812 301-305 Protein denotes NFκB
T13813 307-312 Protein denotes Stat3
T13814 314-318 Protein denotes mTOR
T13815 323-327 Protein denotes MAPK
T13816 281-291 Negative_regulation denotes inhibitors
T13817 281-291 Negative_regulation denotes inhibitors
T13818 281-291 Negative_regulation denotes inhibitors
T13819 281-291 Negative_regulation denotes inhibitors
T13820 281-291 Negative_regulation denotes inhibitors
T13821 532-536 Protein denotes LMP1
T13822 615-641 Protein denotes BAY11–7085, cucurbitacin I
T13823 775-778 Protein denotes Akt
T13824 861-864 Protein denotes Akt
T13825 761-771 Positive_regulation denotes activation
T13826 748-756 Negative_regulation denotes inhibits
T13827 1026-1029 Protein denotes Akt
T13828 1073-1077 Protein denotes LMP1
T13907 4505-4513 Positive_regulation denotes activate
T13908 4505-4513 Positive_regulation denotes activate
T13909 4505-4513 Positive_regulation denotes activate
T13910 4642-4651 Negative_regulation denotes inhibitor
T13911 4683-4692 Negative_regulation denotes inhibitor
T13912 4848-4856 Protein denotes p38 MAPK
T13913 4920-4924 Protein denotes LMP1
T13914 5012-5016 Protein denotes LMP1
T13915 5199-5202 Protein denotes Akt
T13916 5204-5208 Protein denotes NFκB
T13917 5214-5219 Protein denotes Stat3
T13918 5228-5232 Protein denotes MAPK
T13919 5342-5346 Protein denotes mTOR
T13920 5442-5446 Protein denotes mTOR
T13921 5466-5469 Protein denotes Akt
T13922 5484-5488 Protein denotes LMP1
T13923 5185-5195 Positive_regulation denotes activation
T13924 5185-5195 Positive_regulation denotes activation
T13925 5185-5195 Positive_regulation denotes activation
T13926 5185-5195 Positive_regulation denotes activation
T13927 5329-5338 Negative_regulation denotes inhibitor
T13928 5454-5462 Regulation denotes targeted
T25173 1630-1633 Protein denotes Akt
T25174 1635-1639 Protein denotes NFκB
T25175 1645-1650 Protein denotes Stat3
T25176 1816-1820 Protein denotes LMP1
T25177 1901-1905 Protein denotes NFκB
T25178 1907-1912 Protein denotes BAY11
T25179 1915-1919 Protein denotes mTOR
T25180 1921-1930 Protein denotes rapamycin
T25181 1968-1971 Protein denotes p38
T25182 1973-1981 Protein denotes SB202190
T25183 1887-1897 Negative_regulation denotes inhibitors
T25184 1887-1897 Negative_regulation denotes inhibitors
T25185 1887-1897 Negative_regulation denotes inhibitors
T25186 1887-1897 Negative_regulation denotes inhibitors
T25187 1887-1897 Negative_regulation denotes inhibitors
T25188 1887-1897 Negative_regulation denotes inhibitors
T25189 2225-2229 Protein denotes LMP1
T25190 2288-2292 Protein denotes LMP1
T25479 2363-2366 Protein denotes Akt
T25480 2368-2372 Protein denotes NFκB
T25481 2378-2383 Protein denotes Stat3
T25482 2497-2501 Protein denotes LMP1
T25483 2527-2530 Protein denotes Akt
T25484 2532-2536 Protein denotes NFκB
T25485 2542-2547 Protein denotes Stat3
T25486 2586-2589 Protein denotes Akt
T25487 2621-2625 Protein denotes NFκB
T25488 2657-2662 Protein denotes Stat3
T25489 2590-2599 Negative_regulation denotes inhibitor
T25490 2626-2635 Negative_regulation denotes inhibitor
T25491 2663-2673 Negative_regulation denotes inhibitors
T25492 2794-2799 Protein denotes Stat3
T25493 2801-2806 Protein denotes Actin
T13900 4399-4409 Negative_regulation denotes inhibition
T13901 4477-4481 Protein denotes LMP1
T13829 1012-1022 Positive_regulation denotes activation
T13830 1206-1209 Protein denotes Akt
T13831 1211-1216 Protein denotes Stat3
T13832 1238-1242 Protein denotes IκBα
T13833 1191-1205 Phosphorylation denotes phosphorylated
T13834 1191-1205 Phosphorylation denotes phosphorylated
T13835 1321-1324 Protein denotes Akt
T13836 1345-1348 Protein denotes Akt
T13837 1302-1317 Phosphorylation denotes phosphorylation
T13838 1330-1344 Phosphorylation denotes phosphorylated
T13839 1294-1301 Negative_regulation denotes blocked
T13840 1383-1412 Protein denotes Phosphorylated Stat3 and IκBα
T13841 1503-1506 Protein denotes Akt
T13842 1516-1519 Protein denotes Akt
T13843 1495-1502 Regulation denotes targets
T13844 1520-1530 Positive_regulation denotes activation
T13845 2854-2858 Protein denotes NFκB
T13846 2964-2968 Protein denotes NFκB
T13847 3024-3028 Protein denotes LMP1
T13848 2951-2960 Negative_regulation denotes inhibitor
T13849 3219-3222 Protein denotes Akt
T13850 3224-3229 Protein denotes Stat3
T13851 3241-3245 Protein denotes IκBα
T13852 3204-3218 Phosphorylation denotes Phosphorylated
T13853 3204-3218 Phosphorylation denotes Phosphorylated
T13854 3204-3218 Phosphorylation denotes Phosphorylated
T13855 3257-3264 Positive_regulation denotes present
T13856 3257-3264 Positive_regulation denotes present
T13857 3257-3264 Positive_regulation denotes present
T13858 3257-3264 Positive_regulation denotes present
T13859 3316-3324 Positive_regulation denotes detected
T13860 3316-3324 Positive_regulation denotes detected
T13861 3316-3324 Positive_regulation denotes detected
T13862 3378-3382 Protein denotes NFκB
T13863 3408-3412 Protein denotes LMP1
T13864 3500-3503 Protein denotes Akt
T13865 3507-3512 Protein denotes Stat3
T13866 3364-3374 Negative_regulation denotes inhibition
T13867 3486-3496 Positive_regulation denotes activation
T13868 3486-3496 Positive_regulation denotes activation
T13869 3475-3482 Regulation denotes effects
T13870 3475-3482 Regulation denotes effects
T13871 3552-3557 Protein denotes Stat3
T13872 3602-3606 Protein denotes JAK2
T13873 3538-3548 Positive_regulation denotes activation
T13874 3577-3587 Positive_regulation denotes activation
T13875 3561-3572 Negative_regulation denotes suppressing
T13876 3529-3537 Negative_regulation denotes inhibits
T13877 3700-3705 Protein denotes Stat3
T13878 3690-3699 Positive_regulation denotes activated
T13879 3723-3727 Protein denotes LMP1
T13880 3930-3933 Protein denotes Akt
T13881 3935-3940 Protein denotes Stat3
T13882 3952-3956 Protein denotes IκBα
T13883 3915-3929 Phosphorylation denotes Phosphorylated
T13884 3915-3929 Phosphorylation denotes Phosphorylated
T13885 3915-3929 Phosphorylation denotes Phosphorylated
T13886 4039-4048 Negative_regulation denotes decreased
T13887 4039-4048 Negative_regulation denotes decreased
T13888 4039-4048 Negative_regulation denotes decreased
T13889 4135-4140 Protein denotes Stat3
T13890 4203-4206 Protein denotes Akt
T13891 4208-4213 Protein denotes Stat3
T13892 4228-4232 Protein denotes IκBα
T13893 4122-4131 Negative_regulation denotes inhibitor
T13894 4310-4315 Protein denotes Stat3
T13895 4341-4345 Protein denotes LMP1
T13896 4393-4398 Protein denotes Stat3
T13897 4453-4456 Protein denotes Akt
T13898 4461-4465 Protein denotes NFκB
T13899 4296-4306 Negative_regulation denotes inhibition
T13902 4514-4517 Protein denotes JNK
T13903 4522-4525 Protein denotes p38
T13904 4553-4557 Protein denotes LMP1
T13905 4655-4663 Protein denotes p38 MAPK
T13906 4696-4702 Protein denotes MEK1/2
R10554 T13802 T13806 causeOf LMP1,Activation
R10555 T13802 T13807 causeOf LMP1,Activation
R10556 T13802 T13808 causeOf LMP1,Activation
R10557 T13803 T13806 themeOf Akt,Activation
R10558 T13804 T13807 themeOf NFκB,Activation
R10559 T13805 T13808 themeOf Stat3,Activation
R10560 T13811 T13816 themeOf Akt,inhibitors
R10561 T13812 T13817 themeOf NFκB,inhibitors
R10562 T13813 T13818 themeOf Stat3,inhibitors
R10563 T13814 T13819 themeOf mTOR,inhibitors
R10564 T13815 T13820 themeOf MAPK,inhibitors
R10565 T13823 T13825 themeOf Akt,activation
R10566 T13825 T13826 themeOf activation,inhibits
R10567 T13827 T13829 themeOf Akt,activation
R10568 T13830 T13833 themeOf Akt,phosphorylated
R10569 T13831 T13834 themeOf Stat3,phosphorylated
R10570 T13835 T13837 themeOf Akt,phosphorylation
R10571 T13836 T13838 themeOf Akt,phosphorylated
R10572 T13837 T13839 themeOf phosphorylation,blocked
R10573 T13841 T13843 themeOf Akt,targets
R10574 T13842 T13844 themeOf Akt,activation
R10575 T13846 T13848 themeOf NFκB,inhibitor
R10576 T13849 T13852 themeOf Akt,Phosphorylated
R10577 T13850 T13853 themeOf Stat3,Phosphorylated
R10578 T13851 T13854 themeOf IκBα,Phosphorylated
R10579 T13851 T13855 themeOf IκBα,present
R10580 T13852 T13856 themeOf Phosphorylated,present
R10581 T13852 T13859 themeOf Phosphorylated,detected
R10582 T13853 T13857 themeOf Phosphorylated,present
R10583 T13853 T13860 themeOf Phosphorylated,detected
R10584 T13854 T13858 themeOf Phosphorylated,present
R10585 T13854 T13861 themeOf Phosphorylated,detected
R10586 T13862 T13866 themeOf NFκB,inhibition
R10587 T13864 T13867 themeOf Akt,activation
R10588 T13865 T13868 themeOf Stat3,activation
R10589 T13867 T13869 themeOf activation,effects
R10590 T13868 T13870 themeOf activation,effects
R10591 T13871 T13873 themeOf Stat3,activation
R10592 T13872 T13874 themeOf JAK2,activation
R10593 T13873 T13876 themeOf activation,inhibits
R10594 T13874 T13875 themeOf activation,suppressing
R10595 T13875 T13876 causeOf suppressing,inhibits
R10596 T13877 T13878 themeOf Stat3,activated
R10597 T13880 T13883 themeOf Akt,Phosphorylated
R10598 T13880 T13886 themeOf Akt,decreased
R10599 T13881 T13884 themeOf Stat3,Phosphorylated
R10600 T13881 T13887 themeOf Stat3,decreased
R10601 T13882 T13885 themeOf IκBα,Phosphorylated
R10602 T13882 T13888 themeOf IκBα,decreased
R10603 T13889 T13893 themeOf Stat3,inhibitor
R10604 T13894 T13899 themeOf Stat3,inhibition
R10605 T13896 T13900 themeOf Stat3,inhibition
R10606 T13901 T13907 causeOf LMP1,activate
R10607 T13901 T13908 causeOf LMP1,activate
R10608 T13901 T13909 causeOf LMP1,activate
R10609 T13902 T13907 themeOf JNK,activate
R10610 T13903 T13908 themeOf p38,activate
R10611 T13904 T13909 themeOf LMP1,activate
R10612 T13905 T13910 themeOf p38 MAPK,inhibitor
R10613 T13906 T13911 themeOf MEK1/2,inhibitor
R10615 T13915 T13923 themeOf Akt,activation
R10616 T13916 T13924 themeOf NFκB,activation
R10617 T13917 T13925 themeOf Stat3,activation
R10618 T13918 T13926 themeOf MAPK,activation
R10619 T13919 T13927 themeOf mTOR,inhibitor
R10620 T13920 T13928 themeOf mTOR,targeted
R19546 T25177 T25183 themeOf NFκB,inhibitors
R19547 T25178 T25184 themeOf BAY11,inhibitors
R19548 T25179 T25185 themeOf mTOR,inhibitors
R19549 T25180 T25186 themeOf rapamycin,inhibitors
R19550 T25181 T25187 themeOf p38,inhibitors
R19551 T25182 T25188 themeOf SB202190,inhibitors
R19762 T25486 T25489 themeOf Akt,inhibitor
R19763 T25487 T25490 themeOf NFκB,inhibitor
R19764 T25488 T25491 themeOf Stat3,inhibitors

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T11759 1191-1205 Phosphorylation denotes phosphorylated
T11760 1191-1205 Phosphorylation denotes phosphorylated
T11761 1206-1209 Protein denotes Akt
T11762 1211-1216 Protein denotes Stat3
T11763 1238-1242 Protein denotes IκBα
T11764 1294-1301 Negative_regulation denotes blocked
T11765 1302-1317 Phosphorylation denotes phosphorylation
T11766 1321-1324 Protein denotes Akt
T11767 1330-1344 Phosphorylation denotes phosphorylated
T11768 1345-1348 Protein denotes Akt
T11769 1363-1371 Positive_regulation denotes detected true
T11770 1383-1397 Phosphorylation denotes Phosphorylated
T11771 1383-1397 Phosphorylation denotes Phosphorylated
T11772 1398-1403 Protein denotes Stat3
T11773 1408-1412 Protein denotes IκBα
T11774 1495-1502 Regulation denotes targets true
T11800 3602-3606 Protein denotes JAK2
T11801 3690-3699 Positive_regulation denotes activated
T11802 3700-3705 Protein denotes Stat3
T11803 3723-3727 Protein denotes LMP1
T11804 3915-3929 Phosphorylation denotes Phosphorylated
T11805 3915-3929 Phosphorylation denotes Phosphorylated
T11806 3930-3933 Protein denotes Akt
T11807 3935-3940 Protein denotes Stat3
T11808 3952-3956 Protein denotes IκBα
T11809 3966-3976 Positive_regulation denotes detectable true
T11810 3966-3976 Positive_regulation denotes detectable true
T11811 3966-3976 Positive_regulation denotes detectable true
T11812 4039-4048 Negative_regulation denotes decreased
T11813 4039-4048 Negative_regulation denotes decreased
T11814 4039-4048 Negative_regulation denotes decreased
T11815 4122-4131 Negative_regulation denotes inhibitor
T11816 4135-4140 Protein denotes Stat3
T11817 4203-4206 Protein denotes Akt
T11818 4208-4213 Protein denotes Stat3
T11819 4228-4232 Protein denotes IκBα
T11820 4247-4255 Regulation denotes affected true
T11821 4296-4306 Negative_regulation denotes inhibition
T11822 4310-4315 Protein denotes Stat3
T11823 4341-4345 Protein denotes LMP1
T11824 4393-4398 Protein denotes Stat3
T11825 4399-4409 Negative_regulation denotes inhibition
T11826 4453-4456 Protein denotes Akt
T11827 4477-4481 Protein denotes LMP1
T11828 4553-4557 Protein denotes LMP1
T11829 4683-4692 Negative_regulation denotes inhibitor
T11830 4683-4692 Negative_regulation denotes inhibitor
T11831 4696-4700 Protein denotes MEK1
T11832 4701-4702 Protein denotes 2
T11833 4920-4924 Protein denotes LMP1
T11834 5012-5016 Protein denotes LMP1
T11835 5199-5202 Protein denotes Akt
T11836 5214-5219 Protein denotes Stat3
T11837 5329-5338 Negative_regulation denotes inhibitor
T11838 5342-5346 Protein denotes mTOR
T11839 5442-5446 Protein denotes mTOR
T11840 5454-5462 Regulation denotes targeted true
T11841 5466-5469 Protein denotes Akt
T11842 5484-5488 Protein denotes LMP1
T24790 1987-1992 Protein denotes Stat3
T24791 2168-2172 Protein denotes LMP1
T24792 2225-2229 Protein denotes LMP1
T24793 2288-2292 Protein denotes LMP1
T25228 2363-2366 Protein denotes Akt
T25229 2378-2383 Protein denotes Stat3
T25230 2497-2501 Protein denotes LMP1
T25231 2527-2530 Protein denotes Akt
T24777 1630-1633 Protein denotes Akt
T24778 1645-1650 Protein denotes Stat3
T24779 1776-1780 Protein denotes LMP1
T24780 1816-1820 Protein denotes LMP1
T24781 1887-1897 Negative_regulation denotes inhibitors
T24782 1887-1897 Negative_regulation denotes inhibitors
T24783 1887-1897 Negative_regulation denotes inhibitors
T24784 1887-1897 Negative_regulation denotes inhibitors
T24785 1887-1897 Negative_regulation denotes inhibitors
T24786 1915-1919 Protein denotes mTOR
T24787 1933-1936 Protein denotes Akt
T24788 1952-1956 Protein denotes MEK1
T24789 1957-1958 Protein denotes 2
T11740 0-4 Protein denotes LMP1
T11741 62-65 Protein denotes Akt
T11742 77-82 Protein denotes Stat3
T11743 172-176 Protein denotes LMP1
T11744 227-231 Protein denotes LMP1
T11745 281-291 Negative_regulation denotes inhibitors
T11746 281-291 Negative_regulation denotes inhibitors
T11747 281-291 Negative_regulation denotes inhibitors
T11748 296-299 Protein denotes Akt
T11749 307-312 Protein denotes Stat3
T11750 314-318 Protein denotes mTOR
T11751 532-536 Protein denotes LMP1
T11752 748-756 Negative_regulation denotes inhibits
T11753 761-771 Positive_regulation denotes activation
T11754 775-778 Protein denotes Akt
T11755 861-864 Protein denotes Akt
T11756 1012-1022 Positive_regulation denotes activation
T11757 1026-1029 Protein denotes Akt
T11758 1073-1077 Protein denotes LMP1
T11790 3408-3412 Protein denotes LMP1
T11791 3475-3482 Regulation denotes effects true true
T11775 1503-1506 Protein denotes Akt
T11776 1516-1519 Protein denotes Akt
T11777 1520-1530 Positive_regulation denotes activation
T11778 3024-3028 Protein denotes LMP1
T11779 3204-3218 Phosphorylation denotes Phosphorylated
T11780 3204-3218 Phosphorylation denotes Phosphorylated
T11781 3219-3222 Protein denotes Akt
T11782 3224-3229 Protein denotes Stat3
T11783 3241-3245 Protein denotes IκBα
T11784 3257-3264 Positive_regulation denotes present
T11785 3257-3264 Positive_regulation denotes present
T11786 3257-3264 Positive_regulation denotes present
T11787 3316-3324 Positive_regulation denotes detected true
T11788 3316-3324 Positive_regulation denotes detected true
T11789 3316-3324 Positive_regulation denotes detected true
T11792 3475-3482 Regulation denotes effects true true
T11793 3486-3496 Positive_regulation denotes activation
T11794 3486-3496 Positive_regulation denotes activation
T11795 3500-3503 Protein denotes Akt
T11796 3507-3512 Protein denotes Stat3
T11797 3529-3537 Negative_regulation denotes inhibits
T11798 3538-3548 Positive_regulation denotes activation
T11799 3552-3557 Protein denotes Stat3
T25232 2542-2547 Protein denotes Stat3
T25233 2586-2589 Protein denotes Akt
T25234 2590-2599 Negative_regulation denotes inhibitor
T25235 2657-2662 Protein denotes Stat3
T25236 2663-2673 Negative_regulation denotes inhibitors
T25237 2794-2799 Protein denotes Stat3
R8852 T11779 T11788 themeOf Phosphorylated,detected
R8853 T11780 T11784 themeOf Phosphorylated,present
R8854 T11780 T11789 themeOf Phosphorylated,detected
R8855 T11781 T11780 themeOf Akt,Phosphorylated
R8856 T11782 T11779 themeOf Stat3,Phosphorylated
R8857 T11783 T11786 themeOf IκBα,present
R8858 T11783 T11787 themeOf IκBα,detected
R8859 T11793 T11792 themeOf activation,effects
R8860 T11794 T11791 themeOf activation,effects
R8861 T11795 T11794 themeOf Akt,activation
R8862 T11796 T11793 themeOf Stat3,activation
R8863 T11798 T11797 themeOf activation,inhibits
R8864 T11799 T11798 themeOf Stat3,activation
R8865 T11802 T11801 themeOf Stat3,activated
R8866 T11806 T11804 themeOf Akt,Phosphorylated
R8867 T11806 T11810 themeOf Akt,detectable
R8868 T11806 T11814 themeOf Akt,decreased
R8869 T11807 T11805 themeOf Stat3,Phosphorylated
R8870 T11807 T11809 themeOf Stat3,detectable
R8871 T11807 T11813 themeOf Stat3,decreased
R8872 T11808 T11811 themeOf IκBα,detectable
R8873 T11808 T11812 themeOf IκBα,decreased
R8874 T11816 T11815 themeOf Stat3,inhibitor
R8875 T11819 T11820 themeOf IκBα,affected
R8876 T11822 T11821 themeOf Stat3,inhibition
R8877 T11824 T11825 themeOf Stat3,inhibition
R8878 T11831 T11830 themeOf MEK1,inhibitor
R8879 T11832 T11829 themeOf 2,inhibitor
R8880 T11838 T11837 themeOf mTOR,inhibitor
R8881 T11839 T11840 themeOf mTOR,targeted
R19225 T24787 T24783 themeOf Akt,inhibitors
R19226 T24788 T24782 themeOf MEK1,inhibitors
R19227 T24789 T24781 themeOf 2,inhibitors
R19228 T24790 T24785 themeOf Stat3,inhibitors
R19224 T24786 T24784 themeOf mTOR,inhibitors
R8835 T11748 T11746 themeOf Akt,inhibitors
R8836 T11749 T11747 themeOf Stat3,inhibitors
R8837 T11750 T11745 themeOf mTOR,inhibitors
R8838 T11753 T11752 themeOf activation,inhibits
R8839 T11754 T11753 themeOf Akt,activation
R8840 T11757 T11756 themeOf Akt,activation
R8841 T11761 T11759 themeOf Akt,phosphorylated
R8842 T11762 T11760 themeOf Stat3,phosphorylated
R8843 T11765 T11764 themeOf phosphorylation,blocked
R8844 T11766 T11765 themeOf Akt,phosphorylation
R8845 T11767 T11769 themeOf phosphorylated,detected
R8846 T11768 T11767 themeOf Akt,phosphorylated
R8847 T11772 T11771 themeOf Stat3,Phosphorylated
R8848 T11773 T11770 themeOf IκBα,Phosphorylated
R8849 T11775 T11774 themeOf Akt,targets
R8850 T11776 T11777 themeOf Akt,activation
R8851 T11779 T11785 themeOf Phosphorylated,present
R19561 T25233 T25234 themeOf Akt,inhibitor
R19562 T25235 T25236 themeOf Stat3,inhibitors

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T12663 0-4 P03230 denotes LMP1
T12664 62-65 P31749 denotes Akt
T12665 62-65 P31751 denotes Akt
T12666 62-65 Q9Y243 denotes Akt
T12667 77-82 P40763 denotes Stat3
T12668 172-176 P03230 denotes LMP1
T12669 227-231 P03230 denotes LMP1
T12670 296-299 P31749 denotes Akt
T12671 296-299 Q9Y243 denotes Akt
T12672 296-299 P31751 denotes Akt
T12673 307-312 P40763 denotes Stat3
T12674 314-318 P42345 denotes mTOR
T12675 532-536 P03230 denotes LMP1
T12676 775-778 P31749 denotes Akt
T12677 775-778 P31751 denotes Akt
T12678 775-778 Q9Y243 denotes Akt
T12679 861-864 P31749 denotes Akt
T12680 861-864 Q9Y243 denotes Akt
T12681 861-864 P31751 denotes Akt
T12682 1026-1029 P31751 denotes Akt
T12683 1026-1029 Q9Y243 denotes Akt
T12684 1026-1029 P31749 denotes Akt
T12685 1073-1077 P03230 denotes LMP1
T12686 1206-1209 P31751 denotes Akt
T12687 1206-1209 P31749 denotes Akt
T12688 1206-1209 Q9Y243 denotes Akt
T12689 1211-1216 P40763 denotes Stat3
T12690 1238-1242 P25963 denotes IκBα
T12691 1321-1324 P31749 denotes Akt
T12692 1321-1324 Q9Y243 denotes Akt
T12693 1321-1324 P31751 denotes Akt
T12694 1345-1348 P31749 denotes Akt
T12695 1345-1348 Q9Y243 denotes Akt
T12696 1345-1348 P31751 denotes Akt
T12697 1398-1403 P40763 denotes Stat3
T12698 1408-1412 P25963 denotes IκBα
T12699 1503-1506 P31749 denotes Akt
T12700 1503-1506 Q9Y243 denotes Akt
T12701 1503-1506 P31751 denotes Akt
T12702 1516-1519 Q9Y243 denotes Akt
T12703 1516-1519 P31751 denotes Akt
T12704 1516-1519 P31749 denotes Akt
T12705 3024-3028 P03230 denotes LMP1
T12706 3219-3222 P31749 denotes Akt
T12707 3219-3222 P31751 denotes Akt
T12708 3219-3222 Q9Y243 denotes Akt
T12709 3224-3229 P40763 denotes Stat3
T12710 3241-3245 P25963 denotes IκBα
T12711 3408-3412 P03230 denotes LMP1
T12712 3500-3503 Q9Y243 denotes Akt
T12713 3500-3503 P31749 denotes Akt
T12714 3500-3503 P31751 denotes Akt
T12715 3507-3512 P40763 denotes Stat3
T12716 3552-3557 P40763 denotes Stat3
T12717 3700-3705 P40763 denotes Stat3
T12718 3723-3727 P03230 denotes LMP1
T12719 3930-3933 Q9Y243 denotes Akt
T12720 3930-3933 P31751 denotes Akt
T12721 3930-3933 P31749 denotes Akt
T12722 3935-3940 P40763 denotes Stat3
T12723 3952-3956 P25963 denotes IκBα
T12724 4135-4140 P40763 denotes Stat3
T12725 4203-4206 Q9Y243 denotes Akt
T12726 4203-4206 P31751 denotes Akt
T12727 4203-4206 P31749 denotes Akt
T12728 4208-4213 P40763 denotes Stat3
T12729 4228-4232 P25963 denotes IκBα
T12730 4310-4315 P40763 denotes Stat3
T12731 4341-4345 P03230 denotes LMP1
T12732 4393-4398 P40763 denotes Stat3
T12733 4453-4456 P31749 denotes Akt
T12734 4453-4456 P31751 denotes Akt
T12735 4453-4456 Q9Y243 denotes Akt
T12736 4477-4481 P03230 denotes LMP1
T12737 4522-4525 Q15759 denotes p38
T12738 4522-4525 O15264 denotes p38
T12739 4522-4525 Q16539 denotes p38
T12740 4522-4525 P53778 denotes p38
T12741 4553-4557 P03230 denotes LMP1
T12742 4655-4658 P53778 denotes p38
T12743 4655-4658 Q16539 denotes p38
T12744 4655-4658 Q15759 denotes p38
T12745 4655-4658 O15264 denotes p38
T12746 4696-4700 Q02750 denotes MEK1
T12747 4848-4851 Q15759 denotes p38
T12748 4848-4851 Q16539 denotes p38
T12749 4848-4851 O15264 denotes p38
T12750 4848-4851 P53778 denotes p38
T12751 4920-4924 P03230 denotes LMP1
T12752 5012-5016 P03230 denotes LMP1
T12753 5199-5202 P31749 denotes Akt
T12754 5199-5202 Q9Y243 denotes Akt
T12755 5199-5202 P31751 denotes Akt
T12756 5214-5219 P40763 denotes Stat3
T12757 5342-5346 P42345 denotes mTOR
T12758 5442-5446 P42345 denotes mTOR
T12759 5466-5469 Q9Y243 denotes Akt
T12760 5466-5469 P31751 denotes Akt
T12761 5466-5469 P31749 denotes Akt
T12762 5484-5488 P03230 denotes LMP1
T24955 1630-1633 Q9Y243 denotes Akt
T24956 1630-1633 P31751 denotes Akt
T24957 1630-1633 P31749 denotes Akt
T24958 1645-1650 P40763 denotes Stat3
T24959 1776-1780 P03230 denotes LMP1
T24960 1816-1820 P03230 denotes LMP1
T24961 1915-1919 P42345 denotes mTOR
T24962 1933-1936 P31749 denotes Akt
T24963 1933-1936 P31751 denotes Akt
T24964 1933-1936 Q9Y243 denotes Akt
T24965 1952-1956 Q02750 denotes MEK1
T24966 1968-1971 P53778 denotes p38
T24967 1968-1971 Q15759 denotes p38
T24968 1968-1971 Q16539 denotes p38
T24969 1968-1971 O15264 denotes p38
T24970 1987-1992 P40763 denotes Stat3
T24971 2168-2172 P03230 denotes LMP1
T24972 2225-2229 P03230 denotes LMP1
T24973 2288-2292 P03230 denotes LMP1
T25340 2363-2366 Q9Y243 denotes Akt
T25341 2363-2366 P31751 denotes Akt
T25342 2363-2366 P31749 denotes Akt
T25343 2378-2383 P40763 denotes Stat3
T25344 2497-2501 P03230 denotes LMP1
T25345 2527-2530 Q9Y243 denotes Akt
T25346 2527-2530 P31749 denotes Akt
T25347 2527-2530 P31751 denotes Akt
T25348 2542-2547 P40763 denotes Stat3
T25349 2586-2589 Q9Y243 denotes Akt
T25350 2586-2589 P31751 denotes Akt
T25351 2586-2589 P31749 denotes Akt
T25352 2657-2662 P40763 denotes Stat3
T25353 2794-2799 P40763 denotes Stat3

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T11653 0-4 Protein denotes LMP1
T11654 48-58 Positive_regulation denotes Activation
T11655 62-65 Protein denotes Akt
T11656 77-82 Protein denotes Stat3
T11657 172-176 Protein denotes LMP1
T11658 227-231 Protein denotes LMP1
T11659 281-291 Negative_regulation denotes inhibitors
T11660 296-299 Protein denotes Akt
T11661 307-312 Protein denotes Stat3
T11662 314-318 Protein denotes mTOR
T11663 532-536 Protein denotes LMP1
T11664 576-583 Negative_regulation denotes blocked true
T11665 748-756 Negative_regulation denotes inhibits
T11666 761-771 Positive_regulation denotes activation
T11667 775-778 Protein denotes Akt true
T11668 861-864 Protein denotes Akt
T11669 1012-1022 Positive_regulation denotes activation
T11670 1026-1029 Protein denotes Akt
T11671 1073-1077 Protein denotes LMP1
T11672 1191-1205 Phosphorylation denotes phosphorylated
T11673 1206-1209 Protein denotes Akt
T11674 1211-1216 Protein denotes Stat3 true
T11675 1238-1242 Protein denotes IκBα true
T11676 1294-1301 Negative_regulation denotes blocked true
T11677 1302-1317 Phosphorylation denotes phosphorylation true true
T11678 1321-1324 Protein denotes Akt
T11679 1330-1344 Phosphorylation denotes phosphorylated true true
T11680 1345-1348 Protein denotes Akt
T11681 1383-1397 Phosphorylation denotes Phosphorylated
T11682 1398-1403 Protein denotes Stat3
T11683 1408-1412 Protein denotes IκBα
T11684 1495-1502 Binding denotes targets
T11685 1503-1506 Protein denotes Akt
T11686 1516-1519 Protein denotes Akt true
T11687 1520-1530 Positive_regulation denotes activation true
T11688 3024-3028 Protein denotes LMP1 true
T11689 3204-3218 Phosphorylation denotes Phosphorylated
T11690 3219-3222 Protein denotes Akt
T11691 3224-3229 Protein denotes Stat3
T11692 3241-3245 Protein denotes IκBα
T11693 3265-3270 Positive_regulation denotes up to true
T11694 3408-3412 Protein denotes LMP1
T11695 3475-3482 Regulation denotes effects
T11696 3486-3496 Positive_regulation denotes activation
T11697 3500-3503 Protein denotes Akt
T11698 3507-3512 Protein denotes Stat3
T11699 3529-3537 Negative_regulation denotes inhibits true
T11700 3538-3548 Positive_regulation denotes activation
T11701 3552-3557 Protein denotes Stat3
T11702 3602-3606 Protein denotes JAK2
T11703 3690-3699 Positive_regulation denotes activated
T11704 3700-3705 Protein denotes Stat3
T11705 3723-3727 Protein denotes LMP1
T11706 3915-3929 Phosphorylation denotes Phosphorylated
T11707 3930-3933 Protein denotes Akt
T11708 3935-3940 Protein denotes Stat3
T11709 3952-3956 Protein denotes IκBα
T11710 4122-4131 Negative_regulation denotes inhibitor
T11711 4135-4140 Protein denotes Stat3
T11712 4189-4199 Positive_regulation denotes activation
T11713 4203-4206 Protein denotes Akt
T11714 4208-4213 Protein denotes Stat3
T11715 4228-4232 Protein denotes IκBα
T11716 4247-4255 Regulation denotes affected
T11717 4296-4306 Negative_regulation denotes inhibition
T11718 4310-4315 Protein denotes Stat3
T11719 4341-4345 Protein denotes LMP1
T11720 4393-4398 Protein denotes Stat3
T11721 4399-4409 Negative_regulation denotes inhibition
T11722 4453-4456 Protein denotes Akt
T11723 4477-4481 Protein denotes LMP1
T11724 4553-4557 Protein denotes LMP1
T11725 4683-4692 Negative_regulation denotes inhibitor
T11726 4696-4700 Protein denotes MEK1
T11727 4701-4702 Protein denotes 2
T11728 4920-4924 Protein denotes LMP1
T11729 5012-5016 Protein denotes LMP1
T11730 5185-5195 Positive_regulation denotes activation
T11731 5199-5202 Protein denotes Akt
T11732 5214-5219 Protein denotes Stat3
T11733 5329-5338 Negative_regulation denotes inhibitor
T11734 5342-5346 Protein denotes mTOR
T11735 5442-5446 Protein denotes mTOR
T11736 5454-5462 Regulation denotes targeted
T11737 5466-5469 Protein denotes Akt
T11738 5470-5480 Positive_regulation denotes activation
T11739 5484-5488 Protein denotes LMP1
T24765 1630-1633 Protein denotes Akt
T24766 1645-1650 Protein denotes Stat3
T24767 1776-1780 Protein denotes LMP1
T24768 1816-1820 Protein denotes LMP1
T24769 1915-1919 Protein denotes mTOR
T24770 1933-1936 Protein denotes Akt
T24771 1952-1956 Protein denotes MEK1
T24772 1957-1958 Protein denotes 2
T24773 1987-1992 Protein denotes Stat3
T24774 2168-2172 Protein denotes LMP1
T24775 2225-2229 Protein denotes LMP1
T24776 2288-2292 Protein denotes LMP1
T25218 2363-2366 Protein denotes Akt
T25219 2378-2383 Protein denotes Stat3
T25220 2497-2501 Protein denotes LMP1
T25221 2527-2530 Protein denotes Akt
T25222 2542-2547 Protein denotes Stat3
T25223 2586-2589 Protein denotes Akt
T25224 2590-2599 Negative_regulation denotes inhibitor
T25225 2657-2662 Protein denotes Stat3
T25226 2663-2673 Negative_regulation denotes inhibitors
T25227 2794-2799 Protein denotes Stat3
R8796 T11660 T11659 themeOf Akt,inhibitors
R8797 T11661 T11659 themeOf Stat3,inhibitors
R8798 T11662 T11659 themeOf mTOR,inhibitors
R8799 T11666 T11665 themeOf activation,inhibits
R8800 T11667 T11666 themeOf Akt,activation
R8801 T11670 T11669 themeOf Akt,activation
R8802 T11673 T11672 themeOf Akt,phosphorylated
R8803 T11674 T11672 themeOf Stat3,phosphorylated
R8804 T11677 T11676 themeOf phosphorylation,blocked
R8805 T11678 T11677 themeOf Akt,phosphorylation
R8806 T11680 T11679 themeOf Akt,phosphorylated
R8807 T11682 T11681 themeOf Stat3,Phosphorylated
R8808 T11683 T11681 themeOf IκBα,Phosphorylated
R8809 T11685 T11684 themeOf Akt,targets
R8810 T11686 T11687 themeOf Akt,activation
R8811 T11690 T11689 themeOf Akt,Phosphorylated
R8812 T11691 T11689 themeOf Stat3,Phosphorylated
R8813 T11691 T11693 themeOf Stat3,up to
R8814 T11692 T11689 themeOf IκBα,Phosphorylated
R8815 T11692 T11693 themeOf IκBα,up to
R8816 T11696 T11695 themeOf activation,effects
R8817 T11697 T11696 themeOf Akt,activation
R8818 T11698 T11696 themeOf Stat3,activation
R8819 T11700 T11699 themeOf activation,inhibits
R8820 T11701 T11700 themeOf Stat3,activation
R8821 T11704 T11703 themeOf Stat3,activated
R8822 T11707 T11706 themeOf Akt,Phosphorylated
R8823 T11708 T11706 themeOf Stat3,Phosphorylated
R8824 T11709 T11706 themeOf IκBα,Phosphorylated
R8825 T11711 T11710 themeOf Stat3,inhibitor
R8826 T11712 T11716 themeOf activation,affected
R8827 T11713 T11712 themeOf Akt,activation
R8828 T11718 T11717 themeOf Stat3,inhibition
R8829 T11720 T11721 themeOf Stat3,inhibition
R8830 T11726 T11725 themeOf MEK1,inhibitor
R8831 T11727 T11725 themeOf 2,inhibitor
R8832 T11734 T11733 themeOf mTOR,inhibitor
R8833 T11735 T11736 themeOf mTOR,targeted
R8834 T11737 T11738 themeOf Akt,activation
R19559 T25223 T25224 themeOf Akt,inhibitor
R19560 T25225 T25226 themeOf Stat3,inhibitors