PMC:2065877 / 24399-28569 JSON TXT

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2_test

Id	Subject	Object	Predicate	Lexical cue
17997602-16007144-98185730	150-151	16007144	denotes	5
17997602-15714459-98185731	270-272	15714459	denotes	39
17997602-15289331-98185732	273-275	15289331	denotes	40
17997602-15289331-98185733	1117-1119	15289331	denotes	40
17997602-15084260-98185734	2486-2488	15084260	denotes	41
17997602-15668399-98185735	2489-2491	15668399	denotes	42
17997602-10783894-98185736	3284-3286	10783894	denotes	43
17997602-11073996-98185737	3287-3289	11073996	denotes	44
17997602-8343202-98185738	3465-3467	8343202	denotes	45

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T9824	0-4	NN	denotes	LMP1
T9825	5-14	VB	denotes	Activates
T9826	15-18	NN	denotes	Akt
T9827	19-28	NN	denotes	Signaling
T9828	29-32	CC	denotes	and
T9829	33-44	VB	denotes	Deregulates
T9830	45-48	DT	denotes	the
T9831	49-51	NNP	denotes	Rb
T9832	52-56	NNP	denotes	Cell
T9833	57-62	NNP	denotes	Cycle
T9834	63-70	NNP	denotes	Pathway
T9835	71-75	NN	denotes	LMP1
T9836	76-90	NN	denotes	transformation
T9837	91-93	IN	denotes	of
T9838	94-100	JJ	denotes	rodent
T9839	101-112	NN	denotes	fibroblasts
T9840	113-121	VB	denotes	requires
T9841	122-132	NN	denotes	activation
T9842	133-135	IN	denotes	of
T9843	136-140	NN	denotes	PI3K
T9844	141-144	CC	denotes	and
T9845	145-148	NN	denotes	Akt
T9846	149-150	-LRB-	denotes	[
T9847	150-151	CD	denotes	5
T9848	151-152	-RRB-	denotes	]
T9849	154-166	RB	denotes	Additionally
T9850	166-167	-COMMA-	denotes	,
T9851	168-177	VB	denotes	activated
T9852	178-182	NN	denotes	pAkt
T9853	183-185	VB	denotes	is
T9854	186-196	RB	denotes	frequently
T9855	197-205	VB	denotes	detected
T9856	206-208	IN	denotes	in
T9857	209-212	NN	denotes	NPC
T9858	213-216	CC	denotes	and
T9859	217-220	DT	denotes	the
T9860	221-231	JJ	denotes	neoplastic
T9861	232-246	NN	denotes	Reed-Sternberg
T9862	247-252	NN	denotes	cells
T9863	253-255	IN	denotes	of
T9864	256-265	JJ	denotes	classical
T9865	266-268	NN	denotes	HD
T9866	269-270	-LRB-	denotes	[
T9867	270-275	CD	denotes	39,40
T9868	275-276	-RRB-	denotes	]
T9869	278-280	TO	denotes	To
T9870	281-290	VB	denotes	determine
T9871	291-293	IN	denotes	if
T9872	294-297	NN	denotes	Akt
T9873	298-307	NN	denotes	signaling
T9874	308-310	VB	denotes	is
T9875	311-320	VB	denotes	activated
T9876	321-323	IN	denotes	in
T9877	324-328	NN	denotes	LMP1
T9878	329-339	JJ	denotes	transgenic
T9879	340-344	NN	denotes	mice
T9880	344-345	-COMMA-	denotes	,
T9881	346-350	NN	denotes	pAkt
T9882	351-354	CC	denotes	and
T9883	355-362	JJ	denotes	several
T9884	363-365	IN	denotes	of
T9885	366-369	PRP-DOLLAR-	denotes	its
T9886	370-377	NN	denotes	targets
T9887	378-382	VB	denotes	were
T9888	383-391	VB	denotes	assessed
T9889	392-394	IN	denotes	by
T9890	395-409	NN	denotes	immunoblotting
T9891	410-412	IN	denotes	of
T9892	413-420	JJ	denotes	splenic
T9893	421-426	JJ	denotes	CD19+
T9894	427-440	JJ	denotes	MACS-purified
T9895	441-442	NN	denotes	B
T9896	443-448	NN	denotes	cells
T9897	450-454	NN	denotes	LMP1
T9898	455-465	JJ	denotes	transgenic
T9899	466-467	NN	denotes	B
T9900	468-473	NN	denotes	cells
T9901	474-477	VB	denotes	had
T9902	478-487	VB	denotes	increased
T9903	488-494	NN	denotes	levels
T9904	495-497	IN	denotes	of
T9905	498-502	NN	denotes	pAkt
T9906	503-511	VB	denotes	compared
T9907	512-514	TO	denotes	to
T9908	515-524	JJ	denotes	wild-type
T9909	525-536	NN	denotes	lymphocytes
T9910	536-537	-COLON-	denotes	;
T9911	538-545	RB	denotes	however
T9912	545-546	-COMMA-	denotes	,
T9913	547-558	NN	denotes	progression
T9914	559-561	TO	denotes	to
T9915	562-570	NN	denotes	lymphoma
T9916	571-573	IN	denotes	in
T9917	574-578	CC	denotes	both
T9918	579-592	JJ	denotes	LMP1-positive
T9919	593-596	CC	denotes	and
T9920	597-606	JJ	denotes	-negative
T9921	607-615	NN	denotes	lymphoma
T9922	616-621	NN	denotes	cells
T9923	622-625	VB	denotes	did
T9924	626-629	RB	denotes	not
T9925	630-637	RB	denotes	further
T9926	638-646	VB	denotes	increase
T9927	647-651	NN	denotes	pAkt
T9928	652-658	NN	denotes	levels
T9929	660-663	DT	denotes	The
T9930	664-667	NN	denotes	Akt
T9931	668-674	NN	denotes	target
T9932	675-683	NN	denotes	glycogen
T9933	684-692	NN	denotes	synthase
T9934	693-699	NN	denotes	kinase
T9935	700-701	CD	denotes	3
T9936	702-703	-LRB-	denotes	(
T9937	703-707	NN	denotes	GSK3
T9938	707-708	-RRB-	denotes	)
T9939	709-711	VB	denotes	is
T9940	712-723	VB	denotes	inactivated
T9941	724-726	IN	denotes	by
T9942	727-742	NN	denotes	phosphorylation
T9943	742-743	-COLON-	denotes	;
T9944	744-751	RB	denotes	however
T9945	751-752	-COMMA-	denotes	,
T9946	753-762	VB	denotes	increased
T9947	763-777	VB	denotes	phosphorylated
T9948	778-782	NN	denotes	GSK3
T9949	783-786	VB	denotes	was
T9950	787-790	RB	denotes	not
T9951	791-799	VB	denotes	detected
T9952	800-802	IN	denotes	in
T9953	803-806	DT	denotes	the
T9954	807-817	JJ	denotes	transgenic
T9955	818-829	NN	denotes	lymphocytes
T9956	830-833	CC	denotes	and
T9957	834-837	VB	denotes	was
T9958	838-844	RB	denotes	almost
T9959	845-851	JJ	denotes	absent
T9960	852-854	IN	denotes	in
T9961	855-858	DT	denotes	the
T9962	859-867	NN	denotes	lymphoma
T9963	868-875	NN	denotes	samples
T9964	876-877	-LRB-	denotes	(
T9965	877-883	NN	denotes	Figure
T9966	884-886	NN	denotes	6A
T9967	886-887	-RRB-	denotes	)
T9968	889-893	DT	denotes	This
T9969	894-901	NN	denotes	finding
T9970	902-911	VB	denotes	indicates
T9971	912-916	IN	denotes	that
T9972	917-921	NN	denotes	GSK3
T9973	922-924	VB	denotes	is
T9974	925-928	RB	denotes	not
T9975	929-930	DT	denotes	a
T9976	931-937	NN	denotes	target
T9977	938-940	IN	denotes	of
T9978	941-950	VB	denotes	activated
T9979	951-954	NN	denotes	Akt
T9980	955-957	IN	denotes	in
T9981	958-961	DT	denotes	the
T9982	962-966	NN	denotes	LMP1
T9983	967-977	JJ	denotes	transgenic
T9984	978-989	NN	denotes	lymphocytes
T9985	990-993	CC	denotes	and
T9986	994-1002	NN	denotes	lymphoma
T9987	1003-1008	NN	denotes	cells
T9988	1010-1019	RB	denotes	Similarly
T9989	1019-1020	-COMMA-	denotes	,
T9990	1021-1031	NN	denotes	activation
T9991	1032-1034	IN	denotes	of
T9992	1035-1038	NN	denotes	Akt
T9993	1039-1046	IN	denotes	without
T9994	1047-1062	NN	denotes	phosphorylation
T9995	1063-1065	IN	denotes	of
T9996	1066-1070	NN	denotes	GSK3
T9997	1071-1074	VB	denotes	has
T9998	1075-1079	VB	denotes	been
T9999	1080-1090	RB	denotes	previously
T10000	1091-1096	VB	denotes	shown
T10001	1097-1099	IN	denotes	in
T10002	1100-1112	JJ	denotes	EBV-positive
T10003	1113-1115	NN	denotes	HD
T10004	1116-1117	-LRB-	denotes	[
T10005	1117-1119	CD	denotes	40
T10006	1119-1120	-RRB-	denotes	]
T10007	1122-1124	IN	denotes	In
T10008	1125-1133	NN	denotes	contrast
T10009	1133-1134	-COMMA-	denotes	,
T10010	1135-1138	DT	denotes	the
T10011	1139-1148	JJ	denotes	wild-type
T10012	1149-1160	NN	denotes	lymphocytes
T10013	1161-1167	VB	denotes	lacked
T10014	1168-1177	VB	denotes	activated
T10015	1178-1181	NN	denotes	Akt
T10016	1182-1185	CC	denotes	but
T10017	1186-1189	VB	denotes	did
T10018	1190-1194	VB	denotes	have
T10019	1195-1205	JJ	denotes	detectable
T10020	1206-1220	VB	denotes	phosphorylated
T10021	1221-1225	NN	denotes	GSK3
T10022	1227-1231	DT	denotes	This
T10023	1232-1239	RB	denotes	further
T10024	1240-1248	VB	denotes	suggests
T10025	1249-1253	IN	denotes	that
T10026	1254-1264	JJ	denotes	additional
T10027	1265-1273	NN	denotes	pathways
T10028	1274-1277	VB	denotes	are
T10029	1278-1286	VB	denotes	involved
T10030	1287-1289	IN	denotes	in
T10031	1290-1293	DT	denotes	the
T10032	1294-1304	NN	denotes	regulation
T10033	1305-1307	IN	denotes	of
T10034	1308-1312	NN	denotes	GSK3
T10035	1983-1985	TO	denotes	To
T10036	1986-1994	VB	denotes	identify
T10037	1995-2000	JJ	denotes	other
T10038	2001-2010	JJ	denotes	potential
T10039	2011-2014	NN	denotes	Akt
T10040	2015-2022	NN	denotes	targets
T10041	2022-2023	-COMMA-	denotes	,
T10042	2024-2034	NN	denotes	immunoblot
T10043	2035-2043	NN	denotes	analysis
T10044	2044-2047	IN	denotes	for
T10045	2048-2054	NN	denotes	p-mTOR
T10046	2055-2058	VB	denotes	was
T10047	2059-2068	VB	denotes	performed
T10048	2070-2079	VB	denotes	Activated
T10049	2080-2086	NN	denotes	p-mTOR
T10050	2087-2090	VB	denotes	was
T10051	2091-2094	RB	denotes	not
T10052	2095-2104	VB	denotes	increased
T10053	2105-2107	IN	denotes	in
T10054	2108-2112	NN	denotes	LMP1
T10055	2113-2123	JJ	denotes	transgenic
T10056	2124-2135	NN	denotes	lymphocytes
T10057	2136-2138	CC	denotes	or
T10058	2139-2147	NN	denotes	lymphoma
T10059	2148-2153	NN	denotes	cells
T10060	2153-2154	-COMMA-	denotes	,
T10061	2155-2165	VB	denotes	indicating
T10062	2166-2170	IN	denotes	that
T10063	2171-2175	DT	denotes	this
T10064	2176-2183	NN	denotes	pathway
T10065	2184-2186	VB	denotes	is
T10066	2187-2190	RB	denotes	not
T10067	2191-2199	VB	denotes	affected
T10068	2200-2202	IN	denotes	by
T10069	2203-2215	JJ	denotes	LMP1-induced
T10070	2216-2219	NN	denotes	Akt
T10071	2220-2230	NN	denotes	activation
T10072	2231-2234	CC	denotes	and
T10073	2235-2239	VB	denotes	does
T10074	2240-2243	RB	denotes	not
T10075	2244-2254	VB	denotes	contribute
T10076	2255-2257	TO	denotes	to
T10077	2258-2266	NN	denotes	lymphoma
T10078	2267-2278	NN	denotes	development
T10079	2279-2280	-LRB-	denotes	(
T10080	2280-2286	NN	denotes	Figure
T10081	2287-2289	NN	denotes	6B
T10082	2289-2290	-RRB-	denotes	)
T10083	2292-2295	NN	denotes	Akt
T10084	2296-2298	VB	denotes	is
T10085	2299-2303	RB	denotes	also
T10086	2304-2309	VB	denotes	known
T10087	2310-2312	TO	denotes	to
T10088	2313-2326	VB	denotes	phosphorylate
T10089	2327-2330	CC	denotes	and
T10090	2331-2337	VB	denotes	induce
T10091	2338-2341	DT	denotes	the
T10092	2342-2353	NN	denotes	degradation
T10093	2354-2356	IN	denotes	of
T10094	2357-2360	DT	denotes	the
T10095	2361-2374	JJ	denotes	pro-apoptotic
T10096	2375-2383	NN	denotes	Forkhead
T10097	2384-2390	NN	denotes	family
T10098	2391-2393	IN	denotes	of
T10099	2394-2407	NN	denotes	transcription
T10100	2408-2415	NN	denotes	factors
T10101	2415-2416	-COMMA-	denotes	,
T10102	2417-2424	VB	denotes	leading
T10103	2425-2427	TO	denotes	to
T10104	2428-2432	NN	denotes	cell
T10105	2433-2438	NN	denotes	cycle
T10106	2439-2450	NN	denotes	progression
T10107	2451-2454	CC	denotes	and
T10108	2455-2463	NN	denotes	survival
T10109	2464-2466	IN	denotes	in
T10110	2467-2471	DT	denotes	some
T10111	2472-2477	JJ	denotes	human
T10112	2478-2484	NN	denotes	tumors
T10113	2485-2486	-LRB-	denotes	[
T10114	2486-2491	CD	denotes	41,42
T10115	2491-2492	-RRB-	denotes	]
T10116	2494-2504	NN	denotes	Immunoblot
T10117	2505-2513	NN	denotes	analysis
T10118	2514-2516	IN	denotes	of
T10119	2517-2524	JJ	denotes	splenic
T10120	2525-2526	NN	denotes	B
T10121	2527-2532	NN	denotes	cells
T10122	2533-2536	VB	denotes	did
T10123	2537-2540	RB	denotes	not
T10124	2541-2553	RB	denotes	consistently
T10125	2554-2560	VB	denotes	detect
T10126	2561-2568	NN	denotes	p-FoxO1
T10127	2569-2575	NN	denotes	levels
T10128	2575-2576	-COMMA-	denotes	,
T10129	2577-2578	DT	denotes	a
T10130	2579-2585	NN	denotes	signal
T10131	2586-2590	WDT	denotes	that
T10132	2591-2598	VB	denotes	targets
T10133	2599-2604	NN	denotes	FoxO1
T10134	2605-2608	IN	denotes	for
T10135	2609-2620	NN	denotes	degradation
T10136	2622-2627	RB	denotes	Hence
T10137	2627-2628	-COMMA-	denotes	,
T10138	2629-2640	NN	denotes	degradation
T10139	2641-2643	IN	denotes	of
T10140	2644-2649	NN	denotes	FoxO1
T10141	2650-2653	VB	denotes	was
T10142	2654-2662	VB	denotes	assessed
T10143	2663-2665	IN	denotes	by
T10144	2666-2675	NN	denotes	detection
T10145	2676-2678	IN	denotes	of
T10146	2679-2684	JJ	denotes	total
T10147	2685-2690	NN	denotes	FoxO1
T10148	2691-2697	NN	denotes	levels
T10149	2699-2709	NN	denotes	Immunoblot
T10150	2710-2718	NN	denotes	analysis
T10151	2719-2728	VB	denotes	indicated
T10152	2729-2733	IN	denotes	that
T10153	2734-2739	JJ	denotes	total
T10154	2740-2745	NN	denotes	FoxO1
T10155	2746-2752	NN	denotes	levels
T10156	2753-2757	VB	denotes	were
T10157	2758-2765	RB	denotes	greatly
T10158	2766-2775	VB	denotes	decreased
T10159	2776-2778	IN	denotes	in
T10160	2779-2788	JJ	denotes	wild-type
T10161	2789-2792	CC	denotes	and
T10162	2793-2797	NN	denotes	LMP1
T10163	2798-2808	JJ	denotes	transgenic
T10164	2809-2818	NN	denotes	lymphomas
T10165	2819-2820	-LRB-	denotes	(
T10166	2820-2826	NN	denotes	Figure
T10167	2827-2829	NN	denotes	6B
T10168	2829-2830	-RRB-	denotes	)
T10169	2830-2831	-COMMA-	denotes	,
T10170	2832-2842	VB	denotes	suggesting
T10171	2843-2847	IN	denotes	that
T10172	2848-2858	NN	denotes	inhibition
T10173	2859-2861	IN	denotes	of
T10174	2862-2865	DT	denotes	the
T10175	2866-2874	NN	denotes	Forkhead
T10176	2875-2884	NN	denotes	signaling
T10177	2885-2892	NN	denotes	pathway
T10178	2893-2895	VB	denotes	is
T10179	2896-2898	DT	denotes	an
T10180	2899-2908	JJ	denotes	important
T10181	2909-2915	NN	denotes	target
T10182	2916-2918	IN	denotes	of
T10183	2919-2922	NN	denotes	Akt
T10184	2923-2925	IN	denotes	in
T10185	2926-2934	NN	denotes	lymphoma
T10186	2935-2946	NN	denotes	development
T10187	2948-2955	RB	denotes	However
T10188	2955-2956	-COMMA-	denotes	,
T10189	2957-2968	VB	denotes	considering
T10190	2969-2973	IN	denotes	that
T10191	2974-2977	NN	denotes	Akt
T10192	2978-2988	NN	denotes	activation
T10193	2989-2992	VB	denotes	did
T10194	2993-2996	RB	denotes	not
T10195	2997-3003	VB	denotes	induce
T10196	3004-3009	NN	denotes	FoxO1
T10197	3010-3021	NN	denotes	degradation
T10198	3022-3024	IN	denotes	in
T10199	3025-3029	NN	denotes	LMP1
T10200	3030-3040	JJ	denotes	transgenic
T10201	3041-3042	NN	denotes	B
T10202	3043-3048	NN	denotes	cells
T10203	3048-3049	-COMMA-	denotes	,
T10204	3050-3053	NN	denotes	Akt
T10205	3054-3057	MD	denotes	may
T10206	3058-3061	RB	denotes	not
T10207	3062-3064	VB	denotes	be
T10208	3065-3068	DT	denotes	the
T10209	3069-3073	JJ	denotes	sole
T10210	3074-3083	NN	denotes	regulator
T10211	3084-3086	IN	denotes	of
T10212	3087-3092	NN	denotes	FoxO1
T10213	3092-3093	-COMMA-	denotes	,
T10214	3094-3097	CC	denotes	and
T10215	3098-3100	PRP	denotes	it
T10216	3101-3104	MD	denotes	may
T10217	3105-3107	VB	denotes	be
T10218	3108-3112	DT	denotes	that
T10219	3113-3124	NN	denotes	progression
T10220	3125-3127	TO	denotes	to
T10221	3128-3136	NN	denotes	lymphoma
T10222	3137-3145	VB	denotes	requires
T10223	3146-3156	NN	denotes	modulation
T10224	3157-3159	IN	denotes	of
T10225	3160-3168	JJ	denotes	multiple
T10226	3169-3177	NN	denotes	pathways
T10227	3179-3182	DT	denotes	The
T10228	3183-3191	NNP	denotes	Forkhead
T10229	3192-3198	NN	denotes	family
T10230	3199-3201	IN	denotes	of
T10231	3202-3215	NN	denotes	transcription
T10232	3216-3223	NN	denotes	factors
T10233	3224-3226	VB	denotes	is
T10234	3227-3232	VB	denotes	known
T10235	3233-3235	TO	denotes	to
T10236	3236-3242	VB	denotes	induce
T10237	3243-3246	DT	denotes	the
T10238	3247-3257	NN	denotes	expression
T10239	3258-3260	IN	denotes	of
T10240	3261-3264	DT	denotes	the
T10241	3265-3268	NN	denotes	Cdk
T10242	3269-3278	NN	denotes	inhibitor
T10243	3279-3282	NN	denotes	p27
T10244	3283-3284	-LRB-	denotes	[
T10245	3284-3289	CD	denotes	43,44
T10246	3289-3290	-RRB-	denotes	]
T10247	3292-3308	JJ	denotes	LMP1-transformed
T10248	3309-3315	NN	denotes	rodent
T10249	3316-3327	NN	denotes	fibroblasts
T10250	3328-3332	VB	denotes	have
T10251	3333-3342	VB	denotes	decreased
T10252	3343-3353	NN	denotes	expression
T10253	3354-3356	IN	denotes	of
T10254	3357-3360	NN	denotes	p27
T10255	3360-3361	-COMMA-	denotes	,
T10256	3362-3374	NN	denotes	upregulation
T10257	3375-3377	IN	denotes	of
T10258	3378-3382	NN	denotes	Cdk2
T10259	3382-3383	-COMMA-	denotes	,
T10260	3384-3387	CC	denotes	and
T10261	3388-3398	JJ	denotes	subsequent
T10262	3399-3414	NN	denotes	phosphorylation
T10263	3415-3418	CC	denotes	and
T10264	3419-3431	NN	denotes	inactivation
T10265	3432-3434	IN	denotes	of
T10266	3435-3438	DT	denotes	the
T10267	3439-3444	NN	denotes	tumor
T10268	3445-3455	NN	denotes	suppressor
T10269	3456-3460	NN	denotes	gene
T10270	3461-3463	NN	denotes	Rb
T10271	3464-3465	-LRB-	denotes	[
T10272	3465-3467	CD	denotes	45
T10273	3467-3468	-RRB-	denotes	]
T10274	3470-3472	TO	denotes	To
T10275	3473-3484	VB	denotes	investigate
T10276	3485-3492	IN	denotes	whether
T10277	3493-3497	NN	denotes	LMP1
T10278	3498-3506	VB	denotes	affected
T10279	3507-3511	NN	denotes	cell
T10280	3512-3517	NN	denotes	cycle
T10281	3518-3528	NN	denotes	regulation
T10282	3529-3536	IN	denotes	through
T10283	3537-3540	DT	denotes	the
T10284	3541-3543	NN	denotes	Rb
T10285	3544-3551	NN	denotes	pathway
T10286	3552-3554	IN	denotes	in
T10287	3555-3556	NN	denotes	B
T10288	3557-3562	NN	denotes	cells
T10289	3562-3563	-COMMA-	denotes	,
T10290	3564-3574	NN	denotes	immunoblot
T10291	3575-3583	NN	denotes	analyses
T10292	3584-3587	IN	denotes	for
T10293	3588-3591	NN	denotes	pRb
T10294	3591-3592	-COMMA-	denotes	,
T10295	3593-3597	NN	denotes	Cdk2
T10296	3597-3598	-COMMA-	denotes	,
T10297	3599-3602	CC	denotes	and
T10298	3603-3606	NN	denotes	p27
T10299	3607-3611	VB	denotes	were
T10300	3612-3621	VB	denotes	performed
T10301	3622-3624	IN	denotes	on
T10302	3625-3632	JJ	denotes	splenic
T10303	3633-3638	JJ	denotes	CD19+
T10304	3639-3652	JJ	denotes	MACS-purified
T10305	3653-3654	NN	denotes	B
T10306	3655-3660	NN	denotes	cells
T10307	3662-3666	NN	denotes	LMP1
T10308	3667-3677	JJ	denotes	transgenic
T10309	3678-3679	NN	denotes	B
T10310	3680-3685	NN	denotes	cells
T10311	3686-3689	VB	denotes	had
T10312	3690-3698	VB	denotes	enhanced
T10313	3699-3705	NN	denotes	levels
T10314	3706-3708	IN	denotes	of
T10315	3709-3712	NN	denotes	pRb
T10316	3713-3717	IN	denotes	with
T10317	3718-3729	JJ	denotes	concomitant
T10318	3730-3743	NN	denotes	stabilization
T10319	3744-3746	IN	denotes	of
T10320	3747-3752	JJ	denotes	total
T10321	3753-3755	NN	denotes	Rb
T10322	3756-3762	NN	denotes	levels
T10323	3763-3766	CC	denotes	and
T10324	3767-3771	NN	denotes	Cdk2
T10325	3772-3780	VB	denotes	compared
T10326	3781-3783	TO	denotes	to
T10327	3784-3793	JJ	denotes	wild-type
T10328	3794-3795	NN	denotes	B
T10329	3796-3807	NN	denotes	lymphocytes
T10330	3808-3809	-LRB-	denotes	(
T10331	3809-3815	NN	denotes	Figure
T10332	3816-3818	NN	denotes	6C
T10333	3818-3819	-RRB-	denotes	)
T10334	3821-3832	NN	denotes	Progression
T10335	3833-3835	TO	denotes	to
T10336	3836-3844	NN	denotes	lymphoma
T10337	3845-3847	IN	denotes	in
T10338	3848-3852	CC	denotes	both
T10339	3853-3862	JJ	denotes	wild-type
T10340	3863-3866	CC	denotes	and
T10341	3867-3871	NN	denotes	LMP1
T10342	3872-3882	JJ	denotes	transgenic
T10343	3883-3891	NN	denotes	lymphoma
T10344	3892-3897	NN	denotes	cells
T10345	3898-3901	VB	denotes	led
T10346	3902-3904	TO	denotes	to
T10347	3905-3914	VB	denotes	increased
T10348	3915-3921	NN	denotes	levels
T10349	3922-3924	IN	denotes	of
T10350	3925-3927	NN	denotes	Rb
T10351	3927-3928	-COMMA-	denotes	,
T10352	3929-3944	RB	denotes	correspondingly
T10353	3945-3949	JJ	denotes	high
T10354	3950-3956	NN	denotes	levels
T10355	3957-3959	IN	denotes	of
T10356	3960-3964	NN	denotes	Cdk2
T10357	3964-3965	-COMMA-	denotes	,
T10358	3966-3969	CC	denotes	and
T10359	3970-3979	VB	denotes	decreased
T10360	3980-3986	NN	denotes	levels
T10361	3987-3989	IN	denotes	of
T10362	3990-3993	NN	denotes	p27
T10363	3994-3995	-LRB-	denotes	(
T10364	3995-4001	NN	denotes	Figure
T10365	4002-4004	NN	denotes	6C
T10366	4004-4005	-RRB-	denotes	)
T10367	4007-4012	DT	denotes	These
T10368	4013-4017	NN	denotes	data
T10369	4018-4026	VB	denotes	indicate
T10370	4027-4031	IN	denotes	that
T10371	4032-4035	DT	denotes	the
T10372	4036-4038	NN	denotes	Rb
T10373	4039-4046	NN	denotes	pathway
T10374	4047-4049	VB	denotes	is
T10375	4050-4061	VB	denotes	deregulated
T10376	4062-4064	IN	denotes	in
T10377	4065-4069	NN	denotes	LMP1
T10378	4070-4080	JJ	denotes	transgenic
T10379	4081-4092	NN	denotes	lymphocytes
T10380	4093-4096	CC	denotes	and
T10381	4097-4101	IN	denotes	that
T10382	4102-4110	NN	denotes	lymphoma
T10383	4111-4116	NN	denotes	cells
T10384	4117-4120	VB	denotes	are
T10385	4121-4134	VB	denotes	distinguished
T10386	4135-4137	IN	denotes	by
T10387	4138-4142	NN	denotes	loss
T10388	4143-4145	IN	denotes	of
T10389	4146-4151	NN	denotes	FoxO1
T10390	4152-4155	CC	denotes	and
T10391	4156-4165	VB	denotes	decreased
T10392	4166-4169	NN	denotes	p27
T24376	1324-1328	NN	denotes	LMP1
T24377	1329-1338	VB	denotes	Activates
T24378	1339-1342	NN	denotes	Akt
T24379	1343-1352	NN	denotes	Signaling
T24380	1353-1356	CC	denotes	and
T24381	1357-1368	VB	denotes	Deregulates
T24382	1369-1372	DT	denotes	the
T24383	1373-1375	NNP	denotes	Rb
T24384	1376-1380	NNP	denotes	Cell
T24385	1381-1386	NNP	denotes	Cycle
T24386	1387-1394	NNP	denotes	Pathway
T24387	1395-1396	-LRB-	denotes	(
T24388	1396-1397	NN	denotes	A
T24389	1398-1401	CC	denotes	and
T24390	1402-1403	NN	denotes	B
T24391	1403-1404	-RRB-	denotes	)
T24392	1405-1415	NN	denotes	Immunoblot
T24393	1416-1424	NN	denotes	analysis
T24394	1425-1427	IN	denotes	of
T24395	1428-1436	VB	denotes	purified
T24396	1437-1438	NN	denotes	B
T24397	1439-1444	NN	denotes	cells
T24398	1445-1446	-LRB-	denotes	(
T24399	1446-1451	JJ	denotes	CD19+
T24400	1451-1452	-RRB-	denotes	)
T24401	1453-1457	IN	denotes	from
T24402	1458-1461	DT	denotes	the
T24403	1462-1469	NN	denotes	spleens
T24404	1470-1472	IN	denotes	of
T24405	1473-1475	NN	denotes	WT
T24406	1476-1479	CC	denotes	and
T24407	1480-1484	NN	denotes	LMP1
T24408	1485-1495	JJ	denotes	transgenic
T24409	1496-1500	NN	denotes	mice
T24410	1501-1504	IN	denotes	for
T24411	1505-1508	NN	denotes	Akt
T24412	1509-1518	NN	denotes	signaling
T24413	1518-1519	-COMMA-	denotes	,
T24414	1520-1527	VB	denotes	probing
T24415	1528-1531	IN	denotes	for
T24416	1532-1533	-LRB-	denotes	(
T24417	1533-1534	NN	denotes	A
T24418	1534-1535	-RRB-	denotes	)
T24419	1536-1545	VB	denotes	activated
T24420	1546-1550	NN	denotes	pAkt
T24421	1551-1554	CC	denotes	and
T24422	1555-1565	JJ	denotes	downstream
T24423	1566-1573	NN	denotes	targets
T24424	1573-1574	-COMMA-	denotes	,
T24425	1575-1584	VB	denotes	including
T24426	1585-1596	VB	denotes	inactivated
T24427	1597-1605	NN	denotes	pGSK3α/β
T24428	1605-1606	-COMMA-	denotes	,
T24429	1607-1610	CC	denotes	and
T24430	1611-1612	-LRB-	denotes	(
T24431	1612-1613	NN	denotes	B
T24432	1613-1614	-RRB-	denotes	)
T24433	1615-1624	VB	denotes	activated
T24434	1625-1631	NN	denotes	p-mTOR
T24435	1631-1632	-COMMA-	denotes	,
T24436	1633-1636	CC	denotes	and
T24437	1637-1642	JJ	denotes	total
T24438	1643-1649	NN	denotes	levels
T24439	1650-1652	IN	denotes	of
T24440	1653-1658	NN	denotes	FoxO1
T24441	1660-1666	NN	denotes	Arrows
T24442	1667-1675	VB	denotes	indicate
T24443	1676-1679	DT	denotes	the
T24444	1680-1689	NN	denotes	positions
T24445	1690-1692	IN	denotes	of
T24446	1693-1694	NN	denotes	α
T24447	1695-1698	CC	denotes	and
T24448	1699-1700	VB	denotes	β
T24449	1701-1709	NN	denotes	isoforms
T24450	1710-1712	IN	denotes	of
T24451	1713-1717	NN	denotes	GSK3
T24452	1719-1722	DT	denotes	The
T24453	1723-1728	JJ	denotes	white
T24454	1729-1733	NN	denotes	line
T24455	1734-1743	VB	denotes	indicates
T24456	1744-1748	IN	denotes	that
T24457	1749-1760	VB	denotes	intervening
T24458	1761-1766	NN	denotes	lanes
T24459	1767-1771	VB	denotes	have
T24460	1772-1776	VB	denotes	been
T24461	1777-1784	VB	denotes	spliced
T24462	1785-1788	RP	denotes	out
T24463	1790-1791	-LRB-	denotes	(
T24464	1791-1792	NN	denotes	C
T24465	1792-1793	-RRB-	denotes	)
T24466	1794-1804	NN	denotes	Immunoblot
T24467	1805-1813	NN	denotes	analysis
T24468	1814-1817	IN	denotes	for
T24469	1818-1822	NN	denotes	cell
T24470	1823-1828	NN	denotes	cycle
T24471	1829-1837	NN	denotes	proteins
T24472	1838-1848	VB	denotes	regulating
T24473	1849-1852	DT	denotes	the
T24474	1853-1855	NN	denotes	Rb
T24475	1856-1863	NN	denotes	pathway
T24476	1863-1864	-COMMA-	denotes	,
T24477	1865-1872	VB	denotes	probing
T24478	1873-1876	IN	denotes	for
T24479	1877-1886	VB	denotes	activated
T24480	1887-1890	NN	denotes	pRb
T24481	1890-1891	-COMMA-	denotes	,
T24482	1892-1895	CC	denotes	and
T24483	1896-1901	JJ	denotes	total
T24484	1902-1908	NN	denotes	levels
T24485	1909-1911	IN	denotes	of
T24486	1912-1916	NN	denotes	Cdk2
T24487	1917-1920	CC	denotes	and
T24488	1921-1924	DT	denotes	the
T24489	1925-1928	NN	denotes	Cdk
T24490	1929-1938	NN	denotes	inhibitor
T24491	1939-1942	NN	denotes	p27
T24492	1944-1949	NN	denotes	Actin
T24493	1950-1953	VB	denotes	was
T24494	1954-1958	VB	denotes	used
T24495	1959-1961	IN	denotes	as
T24496	1962-1963	DT	denotes	a
T24497	1964-1971	NN	denotes	loading
T24498	1972-1979	NN	denotes	control
R7393	T9824	T9825	arg1Of	LMP1,Activates
R7394	T9824	T9829	arg1Of	LMP1,Deregulates
R7395	T9825	T9828	arg1Of	Activates,and
R7396	T9827	T9825	arg2Of	Signaling,Activates
R7397	T9827	T9826	arg1Of	Signaling,Akt
R7398	T9829	T9828	arg2Of	Deregulates,and
R7403	T9834	T9833	arg1Of	Pathway,Cycle
R7404	T9836	T9835	arg1Of	transformation,LMP1
R7405	T9836	T9837	arg1Of	transformation,of
R7406	T9836	T9840	arg1Of	transformation,requires
R7407	T9839	T9837	arg2Of	fibroblasts,of
R7408	T9839	T9838	arg1Of	fibroblasts,rodent
R7409	T9841	T9842	arg1Of	activation,of
R7410	T9841	T9844	arg1Of	activation,and
R7411	T9843	T9842	arg2Of	PI3K,of
R7412	T9844	T9840	arg2Of	and,requires
R7413	T9845	T9844	arg2Of	Akt,and
R7414	T9845	T9846	arg1Of	Akt,[
R7415	T9847	T9846	arg2Of	5,[
R7416	T9848	T9846	arg3Of	],[
R7417	T9852	T9851	arg2Of	pAkt,activated
R7418	T9852	T9853	arg1Of	pAkt,is
R7419	T9852	T9855	arg2Of	pAkt,detected
R7420	T9855	T9849	arg1Of	detected,Additionally
R7421	T9855	T9850	arg1Of	detected,","
R7422	T9855	T9853	arg2Of	detected,is
R7423	T9855	T9854	arg1Of	detected,frequently
R7424	T9855	T9856	arg1Of	detected,in
R7425	T9857	T9858	arg1Of	NPC,and
R7426	T9858	T9856	arg2Of	and,in
R7427	T9862	T9858	arg2Of	cells,and
R7428	T9862	T9859	arg1Of	cells,the
R7429	T9862	T9860	arg1Of	cells,neoplastic
R7430	T9862	T9861	arg1Of	cells,Reed-Sternberg
R7431	T9862	T9863	arg1Of	cells,of
R7432	T9865	T9863	arg2Of	HD,of
R7433	T9865	T9864	arg1Of	HD,classical
R7434	T9865	T9866	arg1Of	HD,[
R7435	T9867	T9866	arg2Of	"39,40",[
R7436	T9868	T9866	arg3Of	],[
R7437	T9870	T9869	arg1Of	determine,To
R7438	T9873	T9872	arg1Of	signaling,Akt
R7439	T9873	T9874	arg1Of	signaling,is
R7440	T9873	T9875	arg2Of	signaling,activated
R7441	T9875	T9870	arg2Of	activated,determine
R7442	T9875	T9871	arg1Of	activated,if
R7443	T9875	T9874	arg2Of	activated,is
R7444	T9875	T9876	arg1Of	activated,in
R7445	T9879	T9876	arg2Of	mice,in
R7446	T9879	T9877	arg1Of	mice,LMP1
R7447	T9879	T9878	arg1Of	mice,transgenic
R7448	T9881	T9882	arg1Of	pAkt,and
R7449	T9882	T9887	arg1Of	and,were
R7450	T9882	T9888	arg2Of	and,assessed
R7451	T9883	T9882	arg2Of	several,and
R7452	T9883	T9884	arg1Of	several,of
R7453	T9886	T9884	arg2Of	targets,of
R7454	T9886	T9885	arg1Of	targets,its
R7455	T9888	T9869	modOf	assessed,To
R7456	T9888	T9880	arg1Of	assessed,","
R7457	T9888	T9887	arg2Of	assessed,were
R7458	T9890	T9888	arg1Of	immunoblotting,assessed
R7459	T9890	T9889	arg2Of	immunoblotting,by
R7460	T9890	T9891	arg1Of	immunoblotting,of
R7461	T9896	T9891	arg2Of	cells,of
R7462	T9896	T9892	arg1Of	cells,splenic
R7463	T9896	T9893	arg1Of	cells,CD19+
R7464	T9896	T9894	arg1Of	cells,MACS-purified
R7465	T9896	T9895	arg1Of	cells,B
R7466	T9900	T9897	arg1Of	cells,LMP1
R7467	T9900	T9898	arg1Of	cells,transgenic
R7468	T9900	T9899	arg1Of	cells,B
R7469	T9900	T9901	arg1Of	cells,had
R7470	T9900	T9902	arg1Of	cells,increased
R7471	T9902	T9901	arg2Of	increased,had
R7472	T9902	T9906	arg1Of	increased,compared
R7473	T9902	T9910	arg1Of	increased,;
R7474	T9903	T9902	arg2Of	levels,increased
R7475	T9903	T9904	arg1Of	levels,of
R7476	T9905	T9904	arg2Of	pAkt,of
R7477	T9907	T9906	arg2Of	to,compared
R7478	T9909	T9907	arg2Of	lymphocytes,to
R7479	T9909	T9908	arg1Of	lymphocytes,wild-type
R7480	T9913	T9914	arg1Of	progression,to
R7481	T9913	T9916	arg1Of	progression,in
R7482	T9913	T9923	arg1Of	progression,did
R7483	T9913	T9926	arg1Of	progression,increase
R7484	T9915	T9914	arg2Of	lymphoma,to
R7485	T9918	T9919	arg1Of	LMP1-positive,and
R7486	T9920	T9919	arg2Of	-negative,and
R7487	T9922	T9916	arg2Of	cells,in
R7488	T9922	T9917	arg1Of	cells,both
R7489	T9922	T9918	arg1Of	cells,LMP1-positive
R7490	T9922	T9920	arg1Of	cells,-negative
R7491	T9922	T9921	arg1Of	cells,lymphoma
R7492	T9926	T9910	arg2Of	increase,;
R7493	T9926	T9911	arg1Of	increase,however
R7494	T9926	T9912	arg1Of	increase,","
R7495	T9926	T9923	arg2Of	increase,did
R7496	T9926	T9924	arg1Of	increase,not
R7497	T9926	T9925	arg1Of	increase,further
R7498	T9928	T9926	arg2Of	levels,increase
R7499	T9928	T9927	arg1Of	levels,pAkt
R7500	T9934	T9929	arg1Of	kinase,The
R7501	T9934	T9930	arg1Of	kinase,Akt
R7502	T9934	T9931	arg1Of	kinase,target
R7503	T9934	T9932	arg1Of	kinase,glycogen
R7504	T9934	T9933	arg1Of	kinase,synthase
R7505	T9934	T9935	arg1Of	kinase,3
R7506	T9934	T9936	arg1Of	kinase,(
R7507	T9934	T9939	arg1Of	kinase,is
R7508	T9934	T9940	arg2Of	kinase,inactivated
R7509	T9937	T9936	arg2Of	GSK3,(
R7510	T9938	T9936	arg3Of	),(
R7511	T9940	T9939	arg2Of	inactivated,is
R7512	T9940	T9943	arg1Of	inactivated,;
R7513	T9942	T9940	arg1Of	phosphorylation,inactivated
R7514	T9942	T9941	arg2Of	phosphorylation,by
R7515	T9948	T9946	arg2Of	GSK3,increased
R7516	T9948	T9947	arg2Of	GSK3,phosphorylated
R7517	T9948	T9949	arg1Of	GSK3,was
R7518	T9948	T9951	arg2Of	GSK3,detected
R7519	T9948	T9957	arg1Of	GSK3,was
R7520	T9948	T9959	arg1Of	GSK3,absent
R7521	T9951	T9949	arg2Of	detected,was
R7522	T9951	T9950	arg1Of	detected,not
R7523	T9951	T9952	arg1Of	detected,in
R7524	T9951	T9956	arg1Of	detected,and
R7525	T9955	T9952	arg2Of	lymphocytes,in
R7526	T9955	T9953	arg1Of	lymphocytes,the
R7527	T9955	T9954	arg1Of	lymphocytes,transgenic
R7528	T9956	T9943	arg2Of	and,;
R7529	T9956	T9944	arg1Of	and,however
R7530	T9956	T9945	arg1Of	and,","
R7531	T9957	T9956	arg2Of	was,and
R7532	T9959	T9957	arg2Of	absent,was
R7533	T9959	T9958	arg1Of	absent,almost
R7534	T9959	T9960	arg1Of	absent,in
R7535	T9963	T9960	arg2Of	samples,in
R7536	T9963	T9961	arg1Of	samples,the
R7537	T9963	T9962	arg1Of	samples,lymphoma
R7538	T9963	T9964	arg1Of	samples,(
R7539	T9966	T9964	arg2Of	6A,(
R7540	T9966	T9965	arg1Of	6A,Figure
R7541	T9967	T9964	arg3Of	),(
R7542	T9969	T9968	arg1Of	finding,This
R7543	T9969	T9970	arg1Of	finding,indicates
R7544	T9972	T9973	arg1Of	GSK3,is
R7545	T9973	T9970	arg2Of	is,indicates
R7546	T9973	T9971	arg1Of	is,that
R7547	T9973	T9974	arg1Of	is,not
R7548	T9976	T9973	arg2Of	target,is
R7549	T9976	T9975	arg1Of	target,a
R7550	T9976	T9977	arg1Of	target,of
R7551	T9979	T9978	arg2Of	Akt,activated
R7552	T9979	T9980	arg1Of	Akt,in
R7553	T9979	T9985	arg1Of	Akt,and
R7554	T9984	T9980	arg2Of	lymphocytes,in
R7555	T9984	T9981	arg1Of	lymphocytes,the
R7556	T9984	T9982	arg1Of	lymphocytes,LMP1
R7557	T9984	T9983	arg1Of	lymphocytes,transgenic
R7558	T9985	T9977	arg2Of	and,of
R7559	T9987	T9985	arg2Of	cells,and
R7560	T9987	T9986	arg1Of	cells,lymphoma
R7561	T9990	T9991	arg1Of	activation,of
R7562	T9990	T9993	arg1Of	activation,without
R7563	T9990	T9997	arg1Of	activation,has
R7564	T9990	T9998	arg1Of	activation,been
R7565	T9990	T10000	arg2Of	activation,shown
R7566	T9992	T9991	arg2Of	Akt,of
R7567	T9994	T9993	arg2Of	phosphorylation,without
R7568	T9994	T9995	arg1Of	phosphorylation,of
R7569	T9996	T9995	arg2Of	GSK3,of
R7570	T10000	T9988	arg1Of	shown,Similarly
R7571	T10000	T9989	arg1Of	shown,","
R7572	T10000	T9997	arg2Of	shown,has
R7573	T10000	T9998	arg2Of	shown,been
R7574	T10000	T9999	arg1Of	shown,previously
R7575	T10000	T10001	arg1Of	shown,in
R7576	T10003	T10001	arg2Of	HD,in
R7577	T10003	T10002	arg1Of	HD,EBV-positive
R7578	T10003	T10004	arg1Of	HD,[
R7579	T10005	T10004	arg2Of	40,[
R7580	T10006	T10004	arg3Of	],[
R7581	T10008	T10007	arg2Of	contrast,In
R7582	T10012	T10010	arg1Of	lymphocytes,the
R7583	T10012	T10011	arg1Of	lymphocytes,wild-type
R7584	T10012	T10013	arg1Of	lymphocytes,lacked
R7585	T10012	T10017	arg1Of	lymphocytes,did
R7586	T10012	T10018	arg1Of	lymphocytes,have
R7587	T10013	T10016	arg1Of	lacked,but
R7588	T10015	T10013	arg2Of	Akt,lacked
R7589	T10015	T10014	arg2Of	Akt,activated
R7590	T10016	T10007	arg1Of	but,In
R7591	T10016	T10009	arg1Of	but,","
R7592	T10018	T10016	arg2Of	have,but
R7593	T10018	T10017	arg2Of	have,did
R7594	T10021	T10018	arg2Of	GSK3,have
R7595	T10021	T10019	arg1Of	GSK3,detectable
R7596	T10021	T10020	arg2Of	GSK3,phosphorylated
R7597	T10022	T10024	arg1Of	This,suggests
R7598	T10024	T10023	arg1Of	suggests,further
R7599	T10027	T10026	arg1Of	pathways,additional
R7600	T10027	T10028	arg1Of	pathways,are
R7601	T10027	T10029	arg2Of	pathways,involved
R7602	T10029	T10024	arg2Of	involved,suggests
R7603	T10029	T10025	arg1Of	involved,that
R7604	T10029	T10028	arg2Of	involved,are
R7605	T10029	T10030	arg1Of	involved,in
R7606	T10032	T10030	arg2Of	regulation,in
R7607	T10032	T10031	arg1Of	regulation,the
R7608	T10032	T10033	arg1Of	regulation,of
R7609	T10034	T10033	arg2Of	GSK3,of
R7610	T10036	T10035	arg1Of	identify,To
R7611	T10040	T10036	arg2Of	targets,identify
R7612	T10040	T10037	arg1Of	targets,other
R7613	T10040	T10038	arg1Of	targets,potential
R7614	T10040	T10039	arg1Of	targets,Akt
R7615	T10043	T10036	arg1Of	analysis,identify
R7616	T10043	T10042	arg1Of	analysis,immunoblot
R7617	T10043	T10044	arg1Of	analysis,for
R7618	T10043	T10046	arg1Of	analysis,was
R7619	T10043	T10047	arg2Of	analysis,performed
R7620	T10045	T10044	arg2Of	p-mTOR,for
R7621	T10047	T10035	modOf	performed,To
R7622	T10047	T10041	arg1Of	performed,","
R7623	T10047	T10046	arg2Of	performed,was
R7624	T10049	T10048	arg2Of	p-mTOR,Activated
R7625	T10049	T10050	arg1Of	p-mTOR,was
R7626	T10049	T10052	arg2Of	p-mTOR,increased
R7627	T10052	T10050	arg2Of	increased,was
R7628	T10052	T10051	arg1Of	increased,not
R7629	T10052	T10053	arg1Of	increased,in
R7630	T10052	T10060	arg1Of	increased,","
R7631	T10052	T10061	modOf	increased,indicating
R7632	T10056	T10054	arg1Of	lymphocytes,LMP1
R7633	T10056	T10055	arg1Of	lymphocytes,transgenic
R7634	T10056	T10057	arg1Of	lymphocytes,or
R7635	T10057	T10053	arg2Of	or,in
R7636	T10059	T10057	arg2Of	cells,or
R7637	T10059	T10058	arg1Of	cells,lymphoma
R7638	T10064	T10063	arg1Of	pathway,this
R7639	T10064	T10065	arg1Of	pathway,is
R7640	T10064	T10067	arg2Of	pathway,affected
R7641	T10064	T10073	arg1Of	pathway,does
R7642	T10064	T10075	arg1Of	pathway,contribute
R7643	T10067	T10065	arg2Of	affected,is
R7644	T10067	T10066	arg1Of	affected,not
R7645	T10067	T10072	arg1Of	affected,and
R7646	T10071	T10067	arg1Of	activation,affected
R7647	T10071	T10068	arg2Of	activation,by
R7648	T10071	T10069	arg1Of	activation,LMP1-induced
R7649	T10071	T10070	arg1Of	activation,Akt
R7650	T10072	T10061	arg2Of	and,indicating
R7651	T10072	T10062	arg1Of	and,that
R7652	T10075	T10072	arg2Of	contribute,and
R7653	T10075	T10073	arg2Of	contribute,does
R7654	T10075	T10074	arg1Of	contribute,not
R7655	T10075	T10076	arg1Of	contribute,to
R7656	T10078	T10076	arg2Of	development,to
R7657	T10078	T10077	arg1Of	development,lymphoma
R7658	T10078	T10079	arg1Of	development,(
R7659	T10081	T10079	arg2Of	6B,(
R7660	T10081	T10080	arg1Of	6B,Figure
R7661	T10082	T10079	arg3Of	),(
R7662	T10083	T10084	arg1Of	Akt,is
R7663	T10083	T10086	arg2Of	Akt,known
R7664	T10083	T10088	arg1Of	Akt,phosphorylate
R7665	T10083	T10090	arg1Of	Akt,induce
R7666	T10086	T10084	arg2Of	known,is
R7667	T10086	T10085	arg1Of	known,also
R7668	T10088	T10089	arg1Of	phosphorylate,and
R7669	T10089	T10086	arg3Of	and,known
R7670	T10089	T10087	arg1Of	and,to
R7671	T10090	T10089	arg2Of	induce,and
R7672	T10092	T10088	arg2Of	degradation,phosphorylate
R7673	T10092	T10090	arg2Of	degradation,induce
R7674	T10092	T10091	arg1Of	degradation,the
R7675	T10092	T10093	arg1Of	degradation,of
R7676	T10097	T10093	arg2Of	family,of
R7677	T10097	T10094	arg1Of	family,the
R7678	T10097	T10095	arg1Of	family,pro-apoptotic
R7679	T10097	T10096	arg1Of	family,Forkhead
R7680	T10097	T10098	arg1Of	family,of
R7681	T10097	T10101	arg1Of	family,","
R7682	T10097	T10102	arg1Of	family,leading
R7683	T10100	T10098	arg2Of	factors,of
R7684	T10100	T10099	arg1Of	factors,transcription
R7685	T10102	T10103	arg1Of	leading,to
R7686	T10106	T10104	arg1Of	progression,cell
R7687	T10106	T10105	arg1Of	progression,cycle
R7688	T10106	T10107	arg1Of	progression,and
R7689	T10107	T10103	arg2Of	and,to
R7690	T10107	T10109	arg1Of	and,in
R7691	T10108	T10107	arg2Of	survival,and
R7692	T10112	T10109	arg2Of	tumors,in
R7693	T10112	T10110	arg1Of	tumors,some
R7694	T10112	T10111	arg1Of	tumors,human
R7695	T10112	T10113	arg1Of	tumors,[
R7696	T10114	T10113	arg2Of	"41,42",[
R7697	T10115	T10113	arg3Of	],[
R7698	T10117	T10116	arg1Of	analysis,Immunoblot
R7699	T10117	T10118	arg1Of	analysis,of
R7700	T10117	T10122	arg1Of	analysis,did
R7701	T10117	T10125	arg1Of	analysis,detect
R7702	T10121	T10118	arg2Of	cells,of
R7703	T10121	T10119	arg1Of	cells,splenic
R7704	T10121	T10120	arg1Of	cells,B
R7705	T10125	T10122	arg2Of	detect,did
R7706	T10125	T10123	arg1Of	detect,not
R7707	T10125	T10124	arg1Of	detect,consistently
R7708	T10127	T10125	arg2Of	levels,detect
R7709	T10127	T10126	arg1Of	levels,p-FoxO1
R7710	T10127	T10128	arg1Of	levels,","
R7711	T10130	T10128	arg2Of	signal,","
R7712	T10130	T10129	arg1Of	signal,a
R7713	T10130	T10131	arg1Of	signal,that
R7714	T10130	T10132	arg1Of	signal,targets
R7715	T10132	T10134	arg1Of	targets,for
R7716	T10133	T10132	arg2Of	FoxO1,targets
R7717	T10135	T10134	arg2Of	degradation,for
R7718	T10138	T10139	arg1Of	degradation,of
R7719	T10138	T10141	arg1Of	degradation,was
R7720	T10138	T10142	arg2Of	degradation,assessed
R7721	T10140	T10139	arg2Of	FoxO1,of
R7722	T10142	T10136	arg1Of	assessed,Hence
R7723	T10142	T10137	arg1Of	assessed,","
R7724	T10142	T10141	arg2Of	assessed,was
R7725	T10144	T10142	arg1Of	detection,assessed
R7726	T10144	T10143	arg2Of	detection,by
R7727	T10144	T10145	arg1Of	detection,of
R7728	T10148	T10145	arg2Of	levels,of
R7729	T10148	T10146	arg1Of	levels,total
R7730	T10148	T10147	arg1Of	levels,FoxO1
R7731	T10150	T10149	arg1Of	analysis,Immunoblot
R7732	T10150	T10151	arg1Of	analysis,indicated
R7733	T10155	T10153	arg1Of	levels,total
R7734	T10155	T10154	arg1Of	levels,FoxO1
R7735	T10155	T10156	arg1Of	levels,were
R7736	T10155	T10158	arg2Of	levels,decreased
R7737	T10158	T10151	arg2Of	decreased,indicated
R7738	T10158	T10152	arg1Of	decreased,that
R7739	T10158	T10156	arg2Of	decreased,were
R7740	T10158	T10157	arg1Of	decreased,greatly
R7741	T10158	T10159	arg1Of	decreased,in
R7742	T10158	T10169	arg1Of	decreased,","
R7743	T10158	T10170	modOf	decreased,suggesting
R7744	T10160	T10161	arg1Of	wild-type,and
R7745	T10161	T10159	arg2Of	and,in
R7746	T10164	T10161	arg2Of	lymphomas,and
R7747	T10164	T10162	arg1Of	lymphomas,LMP1
R7748	T10164	T10163	arg1Of	lymphomas,transgenic
R7749	T10164	T10165	arg1Of	lymphomas,(
R7750	T10167	T10165	arg2Of	6B,(
R7751	T10167	T10166	arg1Of	6B,Figure
R7752	T10168	T10165	arg3Of	),(
R7753	T10172	T10173	arg1Of	inhibition,of
R7754	T10172	T10178	arg1Of	inhibition,is
R7755	T10177	T10173	arg2Of	pathway,of
R7756	T10177	T10174	arg1Of	pathway,the
R7757	T10177	T10175	arg1Of	pathway,Forkhead
R7758	T10177	T10176	arg1Of	pathway,signaling
R7759	T10178	T10170	arg2Of	is,suggesting
R7760	T10178	T10171	arg1Of	is,that
R7761	T10181	T10178	arg2Of	target,is
R7762	T10181	T10179	arg1Of	target,an
R7763	T10181	T10180	arg1Of	target,important
R7764	T10181	T10182	arg1Of	target,of
R7765	T10181	T10184	arg1Of	target,in
R7766	T10183	T10182	arg2Of	Akt,of
R7767	T10186	T10184	arg2Of	development,in
R7768	T10186	T10185	arg1Of	development,lymphoma
R7769	T10192	T10191	arg1Of	activation,Akt
R7770	T10192	T10193	arg1Of	activation,did
R7771	T10192	T10195	arg1Of	activation,induce
R7772	T10195	T10189	arg2Of	induce,considering
R7773	T10195	T10190	arg1Of	induce,that
R7774	T10195	T10193	arg2Of	induce,did
R7775	T10195	T10194	arg1Of	induce,not
R7776	T10195	T10198	arg1Of	induce,in
R7777	T10197	T10195	arg2Of	degradation,induce
R7778	T10197	T10196	arg1Of	degradation,FoxO1
R7779	T10202	T10198	arg2Of	cells,in
R7780	T10202	T10199	arg1Of	cells,LMP1
R7781	T10202	T10200	arg1Of	cells,transgenic
R7782	T10202	T10201	arg1Of	cells,B
R7783	T10204	T10189	arg1Of	Akt,considering
R7784	T10204	T10205	arg1Of	Akt,may
R7785	T10204	T10207	arg1Of	Akt,be
R7786	T10207	T10205	arg2Of	be,may
R7787	T10207	T10206	arg1Of	be,not
R7788	T10207	T10214	arg1Of	be,and
R7789	T10210	T10207	arg2Of	regulator,be
R7790	T10210	T10208	arg1Of	regulator,the
R7791	T10210	T10209	arg1Of	regulator,sole
R7792	T10210	T10211	arg1Of	regulator,of
R7793	T10212	T10211	arg2Of	FoxO1,of
R7794	T10214	T10187	arg1Of	and,However
R7795	T10214	T10188	arg1Of	and,","
R7796	T10214	T10189	modOf	and,considering
R7797	T10214	T10203	arg1Of	and,","
R7798	T10214	T10213	arg1Of	and,","
R7799	T10215	T10216	arg1Of	it,may
R7800	T10215	T10217	arg1Of	it,be
R7801	T10217	T10214	arg2Of	be,and
R7802	T10217	T10216	arg2Of	be,may
R7803	T10219	T10220	arg1Of	progression,to
R7804	T10219	T10222	arg1Of	progression,requires
R7805	T10221	T10220	arg2Of	lymphoma,to
R7806	T10222	T10217	arg2Of	requires,be
R7807	T10222	T10218	arg1Of	requires,that
R7808	T10223	T10222	arg2Of	modulation,requires
R7809	T10223	T10224	arg1Of	modulation,of
R7810	T10226	T10224	arg2Of	pathways,of
R7811	T10226	T10225	arg1Of	pathways,multiple
R7812	T10229	T10227	arg1Of	family,The
R7813	T10229	T10228	arg1Of	family,Forkhead
R7814	T10229	T10230	arg1Of	family,of
R7815	T10229	T10233	arg1Of	family,is
R7816	T10229	T10234	arg2Of	family,known
R7817	T10229	T10236	arg1Of	family,induce
R7818	T10232	T10230	arg2Of	factors,of
R7819	T10232	T10231	arg1Of	factors,transcription
R7820	T10234	T10233	arg2Of	known,is
R7821	T10236	T10234	arg3Of	induce,known
R7822	T10236	T10235	arg1Of	induce,to
R7823	T10236	T10244	arg1Of	induce,[
R7824	T10238	T10236	arg2Of	expression,induce
R7825	T10238	T10237	arg1Of	expression,the
R7826	T10238	T10239	arg1Of	expression,of
R7827	T10243	T10239	arg2Of	p27,of
R7828	T10243	T10240	arg1Of	p27,the
R7829	T10243	T10241	arg1Of	p27,Cdk
R7830	T10243	T10242	arg1Of	p27,inhibitor
R7831	T10245	T10244	arg2Of	"43,44",[
R7832	T10246	T10244	arg3Of	],[
R7833	T10249	T10247	arg1Of	fibroblasts,LMP1-transformed
R7834	T10249	T10248	arg1Of	fibroblasts,rodent
R7835	T10249	T10250	arg1Of	fibroblasts,have
R7836	T10249	T10251	arg1Of	fibroblasts,decreased
R7837	T10251	T10250	arg2Of	decreased,have
R7838	T10251	T10271	arg1Of	decreased,[
R7839	T10252	T10251	arg2Of	expression,decreased
R7840	T10252	T10253	arg1Of	expression,of
R7841	T10252	T10265	arg1Of	expression,of
R7842	T10254	T10255	arg1Of	p27,","
R7843	T10255	T10260	arg1Of	",",and
R7844	T10256	T10255	arg2Of	upregulation,","
R7845	T10256	T10257	arg1Of	upregulation,of
R7846	T10258	T10257	arg2Of	Cdk2,of
R7847	T10260	T10253	arg2Of	and,of
R7848	T10260	T10259	arg1Of	and,","
R7849	T10262	T10263	arg1Of	phosphorylation,and
R7850	T10263	T10260	arg2Of	and,and
R7851	T10263	T10261	arg1Of	and,subsequent
R7852	T10264	T10263	arg2Of	inactivation,and
R7853	T10270	T10265	arg2Of	Rb,of
R7854	T10270	T10266	arg1Of	Rb,the
R7855	T10270	T10267	arg1Of	Rb,tumor
R7856	T10270	T10268	arg1Of	Rb,suppressor
R7857	T10270	T10269	arg1Of	Rb,gene
R7858	T10272	T10271	arg2Of	45,[
R7859	T10273	T10271	arg3Of	],[
R7860	T10275	T10274	arg1Of	investigate,To
R7861	T10277	T10278	arg1Of	LMP1,affected
R7862	T10278	T10275	arg2Of	affected,investigate
R7863	T10278	T10276	arg1Of	affected,whether
R7864	T10281	T10278	arg2Of	regulation,affected
R7865	T10281	T10279	arg1Of	regulation,cell
R7866	T10281	T10280	arg1Of	regulation,cycle
R7867	T10281	T10282	arg1Of	regulation,through
R7868	T10281	T10286	arg1Of	regulation,in
R7869	T10285	T10282	arg2Of	pathway,through
R7870	T10285	T10283	arg1Of	pathway,the
R7871	T10285	T10284	arg1Of	pathway,Rb
R7872	T10288	T10286	arg2Of	cells,in
R7873	T10288	T10287	arg1Of	cells,B
R7874	T10291	T10275	arg1Of	analyses,investigate
R7875	T10291	T10290	arg1Of	analyses,immunoblot
R7876	T10291	T10292	arg1Of	analyses,for
R7877	T10291	T10299	arg1Of	analyses,were
R7878	T10291	T10300	arg2Of	analyses,performed
R7879	T10293	T10294	arg1Of	pRb,","
R7880	T10294	T10297	arg1Of	",",and
R7881	T10295	T10294	arg2Of	Cdk2,","
R7882	T10297	T10292	arg2Of	and,for
R7883	T10297	T10296	arg1Of	and,","
R7884	T10298	T10297	arg2Of	p27,and
R7885	T10300	T10274	modOf	performed,To
R7886	T10300	T10289	arg1Of	performed,","
R7887	T10300	T10299	arg2Of	performed,were
R7888	T10300	T10301	arg1Of	performed,on
R7889	T10306	T10301	arg2Of	cells,on
R7890	T10306	T10302	arg1Of	cells,splenic
R7891	T10306	T10303	arg1Of	cells,CD19+
R7892	T10306	T10304	arg1Of	cells,MACS-purified
R7893	T10306	T10305	arg1Of	cells,B
R7894	T10310	T10307	arg1Of	cells,LMP1
R7895	T10310	T10308	arg1Of	cells,transgenic
R7896	T10310	T10309	arg1Of	cells,B
R7897	T10310	T10311	arg1Of	cells,had
R7898	T10310	T10312	arg1Of	cells,enhanced
R7899	T10312	T10311	arg2Of	enhanced,had
R7900	T10312	T10325	arg1Of	enhanced,compared
R7901	T10313	T10312	arg2Of	levels,enhanced
R7902	T10313	T10314	arg1Of	levels,of
R7903	T10315	T10314	arg2Of	pRb,of
R7904	T10315	T10316	arg1Of	pRb,with
R7905	T10318	T10317	arg1Of	stabilization,concomitant
R7906	T10318	T10319	arg1Of	stabilization,of
R7907	T10318	T10323	arg1Of	stabilization,and
R7908	T10322	T10319	arg2Of	levels,of
R7909	T10322	T10320	arg1Of	levels,total
R7910	T10322	T10321	arg1Of	levels,Rb
R7911	T10323	T10316	arg2Of	and,with
R7912	T10324	T10323	arg2Of	Cdk2,and
R7913	T10326	T10325	arg2Of	to,compared
R7914	T10329	T10326	arg2Of	lymphocytes,to
R7915	T10329	T10327	arg1Of	lymphocytes,wild-type
R7916	T10329	T10328	arg1Of	lymphocytes,B
R7917	T10329	T10330	arg1Of	lymphocytes,(
R7918	T10332	T10330	arg2Of	6C,(
R7919	T10332	T10331	arg1Of	6C,Figure
R7920	T10333	T10330	arg3Of	),(
R7921	T10334	T10335	arg1Of	Progression,to
R7922	T10334	T10337	arg1Of	Progression,in
R7923	T10334	T10345	arg1Of	Progression,led
R7924	T10334	T10359	arg1Of	Progression,decreased
R7925	T10336	T10335	arg2Of	lymphoma,to
R7926	T10344	T10337	arg2Of	cells,in
R7927	T10344	T10338	arg1Of	cells,both
R7928	T10344	T10339	arg1Of	cells,wild-type
R7929	T10344	T10340	arg1Of	cells,and
R7930	T10344	T10341	arg1Of	cells,LMP1
R7931	T10344	T10342	arg1Of	cells,transgenic
R7932	T10344	T10343	arg1Of	cells,lymphoma
R7933	T10345	T10346	arg1Of	led,to
R7934	T10345	T10358	arg1Of	led,and
R7935	T10348	T10346	arg2Of	levels,to
R7936	T10348	T10347	arg2Of	levels,increased
R7937	T10348	T10349	arg1Of	levels,of
R7938	T10350	T10349	arg2Of	Rb,of
R7939	T10350	T10351	arg1Of	Rb,","
R7940	T10354	T10351	arg2Of	levels,","
R7941	T10354	T10352	arg1Of	levels,correspondingly
R7942	T10354	T10353	arg1Of	levels,high
R7943	T10354	T10355	arg1Of	levels,of
R7944	T10356	T10355	arg2Of	Cdk2,of
R7945	T10358	T10357	arg1Of	and,","
R7946	T10359	T10358	arg2Of	decreased,and
R7947	T10360	T10359	arg2Of	levels,decreased
R7948	T10360	T10361	arg1Of	levels,of
R7949	T10360	T10363	arg1Of	levels,(
R7950	T10362	T10361	arg2Of	p27,of
R7951	T10365	T10363	arg2Of	6C,(
R7952	T10365	T10364	arg1Of	6C,Figure
R7953	T10366	T10363	arg3Of	),(
R7954	T10368	T10367	arg1Of	data,These
R7955	T10368	T10369	arg1Of	data,indicate
R7956	T10373	T10371	arg1Of	pathway,the
R7957	T10373	T10372	arg1Of	pathway,Rb
R7958	T10373	T10374	arg1Of	pathway,is
R7959	T10373	T10375	arg2Of	pathway,deregulated
R7960	T10375	T10370	arg1Of	deregulated,that
R7961	T10375	T10374	arg2Of	deregulated,is
R7962	T10375	T10376	arg1Of	deregulated,in
R7963	T10375	T10380	arg1Of	deregulated,and
R7964	T10379	T10376	arg2Of	lymphocytes,in
R7965	T10379	T10377	arg1Of	lymphocytes,LMP1
R7966	T10379	T10378	arg1Of	lymphocytes,transgenic
R7967	T10380	T10369	arg2Of	and,indicate
R7968	T10381	T10380	arg2Of	that,and
R7969	T10383	T10382	arg1Of	cells,lymphoma
R7970	T10383	T10384	arg1Of	cells,are
R7971	T10383	T10385	arg2Of	cells,distinguished
R7972	T10385	T10381	arg2Of	distinguished,that
R7973	T10385	T10384	arg2Of	distinguished,are
R7974	T10387	T10385	arg1Of	loss,distinguished
R7975	T10387	T10386	arg2Of	loss,by
R7976	T10387	T10388	arg1Of	loss,of
R7977	T10389	T10390	arg1Of	FoxO1,and
R7978	T10390	T10388	arg2Of	and,of
R7979	T10392	T10390	arg2Of	p27,and
R7980	T10392	T10391	arg2Of	p27,decreased
R18940	T24376	T24377	arg1Of	LMP1,Activates
R18941	T24376	T24381	arg1Of	LMP1,Deregulates
R18942	T24377	T24380	arg1Of	Activates,and
R18943	T24379	T24377	arg2Of	Signaling,Activates
R18944	T24379	T24378	arg1Of	Signaling,Akt
R18945	T24381	T24380	arg2Of	Deregulates,and
R18946	T24386	T24381	arg2Of	Pathway,Deregulates
R18947	T24386	T24382	arg1Of	Pathway,the
R18948	T24386	T24383	arg1Of	Pathway,Rb
R18949	T24386	T24384	arg1Of	Pathway,Cell
R18950	T24386	T24385	arg1Of	Pathway,Cycle
R18951	T24388	T24389	arg1Of	A,and
R18952	T24389	T24401	arg1Of	and,from
R18953	T24389	T24429	arg1Of	and,and
R18954	T24393	T24389	arg2Of	analysis,and
R18955	T24393	T24390	arg1Of	analysis,B
R18956	T24393	T24391	arg1Of	analysis,)
R18957	T24393	T24392	arg1Of	analysis,Immunoblot
R18958	T24393	T24394	arg1Of	analysis,of
R18959	T24397	T24394	arg2Of	cells,of
R18960	T24397	T24395	arg2Of	cells,purified
R18961	T24397	T24396	arg1Of	cells,B
R18962	T24397	T24398	arg1Of	cells,(
R18963	T24399	T24398	arg2Of	CD19+,(
R18964	T24400	T24398	arg3Of	),(
R18965	T24403	T24401	arg2Of	spleens,from
R18966	T24403	T24402	arg1Of	spleens,the
R18967	T24403	T24404	arg1Of	spleens,of
R18968	T24403	T24413	arg1Of	spleens,","
R18969	T24403	T24414	arg1Of	spleens,probing
R18970	T24403	T24424	arg1Of	spleens,","
R18971	T24403	T24425	arg1Of	spleens,including
R18972	T24405	T24406	arg1Of	WT,and
R18973	T24406	T24404	arg2Of	and,of
R18974	T24406	T24410	arg1Of	and,for
R18975	T24409	T24406	arg2Of	mice,and
R18976	T24409	T24407	arg1Of	mice,LMP1
R18977	T24409	T24408	arg1Of	mice,transgenic
R18978	T24412	T24410	arg2Of	signaling,for
R18979	T24412	T24411	arg1Of	signaling,Akt
R18980	T24414	T24415	arg1Of	probing,for
R18981	T24417	T24416	arg2Of	A,(
R18982	T24418	T24416	arg3Of	),(
R18983	T24420	T24416	arg1Of	pAkt,(
R18984	T24420	T24419	arg2Of	pAkt,activated
R18985	T24420	T24421	arg1Of	pAkt,and
R18986	T24421	T24415	arg2Of	and,for
R18987	T24423	T24421	arg2Of	targets,and
R18988	T24423	T24422	arg1Of	targets,downstream
R18989	T24427	T24425	arg2Of	pGSK3α/β,including
R18990	T24427	T24426	arg2Of	pGSK3α/β,inactivated
R18991	T24429	T24428	arg1Of	and,","
R18992	T24429	T24433	arg1Of	and,activated
R18993	T24431	T24429	arg2Of	B,and
R18994	T24431	T24430	arg2Of	B,(
R18995	T24432	T24430	arg3Of	),(
R18996	T24433	T24387	arg1Of	activated,(
R18997	T24434	T24436	arg1Of	p-mTOR,and
R18998	T24436	T24435	arg1Of	and,","
R18999	T24437	T24436	arg2Of	total,and
R19000	T24438	T24433	arg2Of	levels,activated
R19001	T24438	T24434	arg1Of	levels,p-mTOR
R19002	T24438	T24437	arg1Of	levels,total
R19003	T24438	T24439	arg1Of	levels,of
R19004	T24440	T24439	arg2Of	FoxO1,of
R19005	T24441	T24442	arg1Of	Arrows,indicate
R19006	T24441	T24448	arg1Of	Arrows,β
R19007	T24442	T24447	arg1Of	indicate,and
R19008	T24444	T24442	arg2Of	positions,indicate
R19009	T24444	T24443	arg1Of	positions,the
R19010	T24444	T24445	arg1Of	positions,of
R19011	T24446	T24445	arg2Of	α,of
R19012	T24448	T24447	arg2Of	β,and
R19013	T24449	T24448	arg2Of	isoforms,β
R19014	T24449	T24450	arg1Of	isoforms,of
R19015	T24451	T24450	arg2Of	GSK3,of
R19016	T24454	T24452	arg1Of	line,The
R19017	T24454	T24453	arg1Of	line,white
R19018	T24454	T24455	arg1Of	line,indicates
R19019	T24458	T24457	arg1Of	lanes,intervening
R19020	T24458	T24459	arg1Of	lanes,have
R19021	T24458	T24460	arg1Of	lanes,been
R19022	T24458	T24461	arg2Of	lanes,spliced
R19023	T24461	T24455	arg2Of	spliced,indicates
R19024	T24461	T24456	arg1Of	spliced,that
R19025	T24461	T24459	arg2Of	spliced,have
R19026	T24461	T24460	arg2Of	spliced,been
R19027	T24461	T24462	arg1Of	spliced,out
R19028	T24464	T24463	arg2Of	C,(
R19029	T24465	T24463	arg3Of	),(
R19030	T24467	T24463	arg1Of	analysis,(
R19031	T24467	T24466	arg1Of	analysis,Immunoblot
R19032	T24467	T24468	arg1Of	analysis,for
R19033	T24471	T24469	arg1Of	proteins,cell
R19034	T24471	T24470	arg1Of	proteins,cycle
R19035	T24471	T24472	arg1Of	proteins,regulating
R19036	T24471	T24482	arg1Of	proteins,and
R19037	T24472	T24476	arg1Of	regulating,","
R19038	T24472	T24477	modOf	regulating,probing
R19039	T24475	T24472	arg2Of	pathway,regulating
R19040	T24475	T24473	arg1Of	pathway,the
R19041	T24475	T24474	arg1Of	pathway,Rb
R19042	T24477	T24478	arg1Of	probing,for
R19043	T24480	T24478	arg2Of	pRb,for
R19044	T24480	T24479	arg2Of	pRb,activated
R19045	T24482	T24468	arg2Of	and,for
R19046	T24482	T24481	arg1Of	and,","
R19047	T24484	T24482	arg2Of	levels,and
R19048	T24484	T24483	arg1Of	levels,total
R19049	T24484	T24485	arg1Of	levels,of
R19050	T24486	T24487	arg1Of	Cdk2,and
R19051	T24490	T24487	arg2Of	inhibitor,and
R19052	T24490	T24488	arg1Of	inhibitor,the
R19053	T24490	T24489	arg1Of	inhibitor,Cdk
R19054	T24491	T24485	arg2Of	p27,of
R19055	T24491	T24486	arg1Of	p27,Cdk2
R19056	T24491	T24490	arg1Of	p27,inhibitor
R19057	T24492	T24493	arg1Of	Actin,was
R19058	T24492	T24494	arg2Of	Actin,used
R19059	T24494	T24493	arg2Of	used,was
R19060	T24494	T24495	arg1Of	used,as
R19061	T24498	T24495	arg2Of	control,as
R19062	T24498	T24496	arg1Of	control,a
R19063	T24498	T24497	arg1Of	control,loading
R7399	T9834	T9829	arg2Of	Pathway,Deregulates
R7400	T9834	T9830	arg1Of	Pathway,the
R7401	T9834	T9831	arg1Of	Pathway,Rb
R7402	T9834	T9832	arg1Of	Pathway,Cell

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T10393	2171-2183	Anaphor	denotes	this pathway
T10394	2070-2079	Antecedent	denotes	Activated
R7981	T10393	T10394	boundBy	this pathway,Activated

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T10502	0-4	CD	denotes	LMP1
T10503	5-14	NNP	denotes	Activates
T10504	15-18	NNP	denotes	Akt
T10505	19-28	VBG	denotes	Signaling
T10506	29-32	CC	denotes	and
T10507	33-44	VBZ	denotes	Deregulates
T10508	45-48	DT	denotes	the
T10509	49-51	NNP	denotes	Rb
T10510	52-56	NNP	denotes	Cell
T10511	57-62	NNP	denotes	Cycle
T10512	63-70	NNP	denotes	Pathway
T10513	71-75	NNP	denotes	LMP1
T10514	76-90	NN	denotes	transformation
T10515	91-93	IN	denotes	of
T10516	94-100	NN	denotes	rodent
T10517	101-112	NNS	denotes	fibroblasts
T10518	113-121	VBZ	denotes	requires
T10519	122-132	NN	denotes	activation
T10520	133-135	IN	denotes	of
T10521	136-140	NNP	denotes	PI3K
T10522	141-144	CC	denotes	and
T10523	145-148	NNP	denotes	Akt
T10524	149-150	NNP	denotes	[
T10525	150-151	CD	denotes	5
T10526	151-152	NNP	denotes	]
T10527	152-153	.	denotes	.
T10528	154-166	RB	denotes	Additionally
T10529	166-167	,	denotes	,
T10530	168-177	VBN	denotes	activated
T10531	178-182	NNP	denotes	pAkt
T10532	183-185	VBZ	denotes	is
T10533	186-196	RB	denotes	frequently
T10534	197-205	VBN	denotes	detected
T10535	206-208	IN	denotes	in
T10536	209-212	NNP	denotes	NPC
T10537	213-216	CC	denotes	and
T10538	217-220	DT	denotes	the
T10539	221-231	JJ	denotes	neoplastic
T10540	232-246	NNP	denotes	Reed-Sternberg
T10541	247-252	NNS	denotes	cells
T10542	253-255	IN	denotes	of
T10543	256-265	JJ	denotes	classical
T10544	266-268	NNP	denotes	HD
T10545	269-270	NNP	denotes	[
T10546	270-275	CD	denotes	39,40
T10547	275-276	NNP	denotes	]
T10548	276-277	.	denotes	.
T10549	278-280	TO	denotes	To
T10550	281-290	VB	denotes	determine
T10551	291-293	IN	denotes	if
T10552	294-297	NNP	denotes	Akt
T10553	298-307	VBG	denotes	signaling
T10554	308-310	VBZ	denotes	is
T10555	311-320	VBN	denotes	activated
T10556	321-323	IN	denotes	in
T10557	324-328	CD	denotes	LMP1
T10558	329-339	JJ	denotes	transgenic
T10559	340-344	NNS	denotes	mice
T10560	344-345	,	denotes	,
T10561	346-350	NNP	denotes	pAkt
T10562	351-354	CC	denotes	and
T10563	355-362	JJ	denotes	several
T10564	363-365	IN	denotes	of
T10565	366-369	PRP$	denotes	its
T10566	370-377	NNS	denotes	targets
T10567	378-382	VBD	denotes	were
T10568	383-391	VBN	denotes	assessed
T10569	392-394	IN	denotes	by
T10570	395-409	VBG	denotes	immunoblotting
T10571	410-412	IN	denotes	of
T10572	413-420	JJ	denotes	splenic
T10573	421-425	NNP	denotes	CD19
T10574	425-426	NNP	denotes	+
T10575	427-440	NNP	denotes	MACS-purified
T10576	441-442	NNP	denotes	B
T10577	443-448	NNS	denotes	cells
T10578	448-449	.	denotes	.
T10579	450-454	CD	denotes	LMP1
T10580	455-465	JJ	denotes	transgenic
T10581	466-467	NNP	denotes	B
T10582	468-473	NNS	denotes	cells
T10583	474-477	VBD	denotes	had
T10584	478-487	VBN	denotes	increased
T10585	488-494	NNS	denotes	levels
T10586	495-497	IN	denotes	of
T10587	498-502	NN	denotes	pAkt
T10588	503-511	VBN	denotes	compared
T10589	512-514	TO	denotes	to
T10590	515-524	JJ	denotes	wild-type
T10591	525-536	NNS	denotes	lymphocytes
T10592	536-537	:	denotes	;
T10593	538-545	RB	denotes	however
T10594	545-546	,	denotes	,
T10595	547-558	NN	denotes	progression
T10596	559-561	TO	denotes	to
T10597	562-570	NN	denotes	lymphoma
T10598	571-573	IN	denotes	in
T10599	574-578	DT	denotes	both
T10600	579-592	JJ	denotes	LMP1-positive
T10601	593-596	CC	denotes	and
T10602	597-598	:	denotes	-
T10603	598-606	JJ	denotes	negative
T10604	607-615	NN	denotes	lymphoma
T10605	616-621	NNS	denotes	cells
T10606	622-625	VBD	denotes	did
T10607	626-629	RB	denotes	not
T10608	630-637	JJ	denotes	further
T10609	638-646	NN	denotes	increase
T10610	647-651	NN	denotes	pAkt
T10611	652-658	NNS	denotes	levels
T10612	658-659	.	denotes	.
T10613	660-663	DT	denotes	The
T10614	664-667	NNP	denotes	Akt
T10615	668-674	NN	denotes	target
T10616	675-683	NN	denotes	glycogen
T10617	684-692	NN	denotes	synthase
T10618	693-699	NN	denotes	kinase
T10619	700-701	CD	denotes	3
T10620	702-703	-LRB-	denotes	(
T10621	703-707	NN	denotes	GSK3
T10622	707-708	-RRB-	denotes	)
T10623	709-711	VBZ	denotes	is
T10624	712-723	VBN	denotes	inactivated
T10625	724-726	IN	denotes	by
T10626	727-742	NN	denotes	phosphorylation
T10627	742-743	:	denotes	;
T10628	744-751	RB	denotes	however
T10629	751-752	,	denotes	,
T10630	753-762	VBD	denotes	increased
T10631	763-777	VBN	denotes	phosphorylated
T10632	778-782	NNP	denotes	GSK3
T10633	783-786	VBD	denotes	was
T10634	787-790	RB	denotes	not
T10635	791-799	VBN	denotes	detected
T10636	800-802	IN	denotes	in
T10637	803-806	DT	denotes	the
T10638	807-817	JJ	denotes	transgenic
T10639	818-829	NNS	denotes	lymphocytes
T10640	830-833	CC	denotes	and
T10641	834-837	VBD	denotes	was
T10642	838-844	RB	denotes	almost
T10643	845-851	JJ	denotes	absent
T10644	852-854	IN	denotes	in
T10645	855-858	DT	denotes	the
T10646	859-867	NN	denotes	lymphoma
T10647	868-875	NNS	denotes	samples
T10648	876-877	-LRB-	denotes	(
T10649	877-883	NN	denotes	Figure
T10650	884-886	NN	denotes	6A
T10651	886-887	-RRB-	denotes	)
T10652	887-888	.	denotes	.
T10653	889-893	DT	denotes	This
T10654	894-901	NN	denotes	finding
T10655	902-911	VBZ	denotes	indicates
T10656	912-916	IN	denotes	that
T10657	917-921	NNP	denotes	GSK3
T10658	922-924	VBZ	denotes	is
T10659	925-928	RB	denotes	not
T10660	929-930	DT	denotes	a
T10661	931-937	NN	denotes	target
T10662	938-940	IN	denotes	of
T10663	941-950	VBN	denotes	activated
T10664	951-954	NNP	denotes	Akt
T10665	955-957	IN	denotes	in
T10666	958-961	DT	denotes	the
T10667	962-966	NNP	denotes	LMP1
T10668	967-977	NN	denotes	transgenic
T10669	978-989	NNS	denotes	lymphocytes
T10670	990-993	CC	denotes	and
T10671	994-1002	NN	denotes	lymphoma
T10672	1003-1008	NNS	denotes	cells
T10673	1008-1009	.	denotes	.
T10674	1010-1019	RB	denotes	Similarly
T10675	1019-1020	,	denotes	,
T10676	1021-1031	NN	denotes	activation
T10677	1032-1034	IN	denotes	of
T10678	1035-1038	NNP	denotes	Akt
T10679	1039-1046	IN	denotes	without
T10680	1047-1062	NN	denotes	phosphorylation
T10681	1063-1065	IN	denotes	of
T10682	1066-1070	NNP	denotes	GSK3
T10683	1071-1074	VBZ	denotes	has
T10684	1075-1079	VBN	denotes	been
T10685	1080-1090	RB	denotes	previously
T10686	1091-1096	VBN	denotes	shown
T10687	1097-1099	IN	denotes	in
T10688	1100-1112	JJ	denotes	EBV-positive
T10689	1113-1115	NNP	denotes	HD
T10690	1116-1117	NNP	denotes	[
T10691	1117-1119	CD	denotes	40
T10692	1119-1120	NNP	denotes	]
T10693	1120-1121	.	denotes	.
T10694	1122-1124	IN	denotes	In
T10695	1125-1133	NN	denotes	contrast
T10696	1133-1134	,	denotes	,
T10697	1135-1138	DT	denotes	the
T10698	1139-1148	JJ	denotes	wild-type
T10699	1149-1160	NNS	denotes	lymphocytes
T10700	1161-1167	VBD	denotes	lacked
T10701	1168-1177	VBN	denotes	activated
T10702	1178-1181	NNP	denotes	Akt
T10703	1182-1185	CC	denotes	but
T10704	1186-1189	VBD	denotes	did
T10705	1190-1194	VB	denotes	have
T10706	1195-1205	JJ	denotes	detectable
T10707	1206-1220	VBN	denotes	phosphorylated
T10708	1221-1225	NNP	denotes	GSK3
T10709	1225-1226	.	denotes	.
T10710	1227-1231	DT	denotes	This
T10711	1232-1239	JJ	denotes	further
T10712	1240-1248	VBZ	denotes	suggests
T10713	1249-1253	IN	denotes	that
T10714	1254-1264	JJ	denotes	additional
T10715	1265-1273	NNS	denotes	pathways
T10716	1274-1277	VBP	denotes	are
T10717	1278-1286	VBN	denotes	involved
T10718	1287-1289	IN	denotes	in
T10719	1290-1293	DT	denotes	the
T10720	1294-1304	NN	denotes	regulation
T10721	1305-1307	IN	denotes	of
T10722	1308-1312	NNP	denotes	GSK3
T10723	1312-1313	.	denotes	.
T10724	1983-1985	TO	denotes	To
T10725	1986-1994	VB	denotes	identify
T10726	1995-2000	JJ	denotes	other
T10727	2001-2010	JJ	denotes	potential
T10728	2011-2014	NNP	denotes	Akt
T10729	2015-2022	NNS	denotes	targets
T10730	2022-2023	,	denotes	,
T10731	2024-2034	NN	denotes	immunoblot
T10732	2035-2043	NN	denotes	analysis
T10733	2044-2047	IN	denotes	for
T10734	2048-2054	NN	denotes	p-mTOR
T10735	2055-2058	VBD	denotes	was
T10736	2059-2068	VBN	denotes	performed
T10737	2068-2069	.	denotes	.
T10738	2070-2079	VBN	denotes	Activated
T10739	2080-2086	NN	denotes	p-mTOR
T10740	2087-2090	VBD	denotes	was
T10741	2091-2094	RB	denotes	not
T10742	2095-2104	VBN	denotes	increased
T10743	2105-2107	IN	denotes	in
T10744	2108-2112	CD	denotes	LMP1
T10745	2113-2123	JJ	denotes	transgenic
T10746	2124-2135	NNS	denotes	lymphocytes
T10747	2136-2138	CC	denotes	or
T10748	2139-2147	NN	denotes	lymphoma
T10749	2148-2153	NNS	denotes	cells
T10750	2153-2154	,	denotes	,
T10751	2155-2165	VBG	denotes	indicating
T10752	2166-2170	IN	denotes	that
T10753	2171-2175	DT	denotes	this
T10754	2176-2183	NN	denotes	pathway
T10755	2184-2186	VBZ	denotes	is
T10756	2187-2190	RB	denotes	not
T10757	2191-2199	VBN	denotes	affected
T10758	2200-2202	IN	denotes	by
T10759	2203-2215	JJ	denotes	LMP1-induced
T10760	2216-2219	NNP	denotes	Akt
T10761	2220-2230	NN	denotes	activation
T10762	2231-2234	CC	denotes	and
T10763	2235-2239	VBZ	denotes	does
T10764	2240-2243	RB	denotes	not
T10765	2244-2254	VB	denotes	contribute
T10766	2255-2257	TO	denotes	to
T10767	2258-2266	VB	denotes	lymphoma
T10768	2267-2278	NN	denotes	development
T10769	2279-2280	-LRB-	denotes	(
T10770	2280-2286	NN	denotes	Figure
T10771	2287-2289	NN	denotes	6B
T10772	2289-2290	-RRB-	denotes	)
T10773	2290-2291	.	denotes	.
T10774	2292-2295	NNP	denotes	Akt
T10775	2296-2298	VBZ	denotes	is
T10776	2299-2303	RB	denotes	also
T10777	2304-2309	VBN	denotes	known
T10778	2310-2312	TO	denotes	to
T10779	2313-2326	VB	denotes	phosphorylate
T10780	2327-2330	CC	denotes	and
T10781	2331-2337	VB	denotes	induce
T10782	2338-2341	DT	denotes	the
T10783	2342-2353	NN	denotes	degradation
T10784	2354-2356	IN	denotes	of
T10785	2357-2360	DT	denotes	the
T10786	2361-2374	JJ	denotes	pro-apoptotic
T10787	2375-2383	NNP	denotes	Forkhead
T10788	2384-2390	NN	denotes	family
T10789	2391-2393	IN	denotes	of
T10790	2394-2407	NN	denotes	transcription
T10791	2408-2415	NNS	denotes	factors
T10792	2415-2416	,	denotes	,
T10793	2417-2424	VBG	denotes	leading
T10794	2425-2427	TO	denotes	to
T10795	2428-2432	NN	denotes	cell
T10796	2433-2438	NN	denotes	cycle
T10797	2439-2450	NN	denotes	progression
T10798	2451-2454	CC	denotes	and
T10799	2455-2463	NN	denotes	survival
T10800	2464-2466	IN	denotes	in
T10801	2467-2471	DT	denotes	some
T10802	2472-2477	JJ	denotes	human
T10803	2478-2484	NNS	denotes	tumors
T10804	2485-2486	NNP	denotes	[
T10805	2486-2491	CD	denotes	41,42
T10806	2491-2492	NNP	denotes	]
T10807	2492-2493	.	denotes	.
T10808	2494-2504	NNP	denotes	Immunoblot
T10809	2505-2513	NN	denotes	analysis
T10810	2514-2516	IN	denotes	of
T10811	2517-2524	JJ	denotes	splenic
T10812	2525-2526	NNP	denotes	B
T10813	2527-2532	NNS	denotes	cells
T10814	2533-2536	VBD	denotes	did
T10815	2537-2540	RB	denotes	not
T10816	2541-2553	RB	denotes	consistently
T10817	2554-2560	VB	denotes	detect
T10818	2561-2568	JJ	denotes	p-FoxO1
T10819	2569-2575	NNS	denotes	levels
T10820	2575-2576	,	denotes	,
T10821	2577-2578	DT	denotes	a
T10822	2579-2585	NN	denotes	signal
T10823	2586-2590	WDT	denotes	that
T10824	2591-2598	VBZ	denotes	targets
T10825	2599-2604	NNP	denotes	FoxO1
T10826	2605-2608	IN	denotes	for
T10827	2609-2620	NN	denotes	degradation
T10828	2620-2621	.	denotes	.
T10829	2622-2627	RB	denotes	Hence
T10830	2627-2628	,	denotes	,
T10831	2629-2640	NN	denotes	degradation
T10832	2641-2643	IN	denotes	of
T10833	2644-2649	NNP	denotes	FoxO1
T10834	2650-2653	VBD	denotes	was
T10835	2654-2662	VBN	denotes	assessed
T10836	2663-2665	IN	denotes	by
T10837	2666-2675	NN	denotes	detection
T10838	2676-2678	IN	denotes	of
T10839	2679-2684	JJ	denotes	total
T10840	2685-2690	JJ	denotes	FoxO1
T10841	2691-2697	NNS	denotes	levels
T10842	2697-2698	.	denotes	.
T10843	2699-2709	NNP	denotes	Immunoblot
T10844	2710-2718	NN	denotes	analysis
T10845	2719-2728	VBD	denotes	indicated
T10846	2729-2733	IN	denotes	that
T10847	2734-2739	JJ	denotes	total
T10848	2740-2745	JJ	denotes	FoxO1
T10849	2746-2752	NNS	denotes	levels
T10850	2753-2757	VBD	denotes	were
T10851	2758-2765	RB	denotes	greatly
T10852	2766-2775	VBN	denotes	decreased
T10853	2776-2778	IN	denotes	in
T10854	2779-2788	JJ	denotes	wild-type
T10855	2789-2792	CC	denotes	and
T10856	2793-2797	JJ	denotes	LMP1
T10857	2798-2808	JJ	denotes	transgenic
T10858	2809-2818	NNS	denotes	lymphomas
T10859	2819-2820	-LRB-	denotes	(
T10860	2820-2826	NN	denotes	Figure
T10861	2827-2829	NN	denotes	6B
T10862	2829-2830	-RRB-	denotes	)
T10863	2830-2831	,	denotes	,
T10864	2832-2842	VBG	denotes	suggesting
T10865	2843-2847	IN	denotes	that
T10866	2848-2858	NN	denotes	inhibition
T10867	2859-2861	IN	denotes	of
T10868	2862-2865	DT	denotes	the
T10869	2866-2874	NNP	denotes	Forkhead
T10870	2875-2884	VBG	denotes	signaling
T10871	2885-2892	NN	denotes	pathway
T10872	2893-2895	VBZ	denotes	is
T10873	2896-2898	DT	denotes	an
T10874	2899-2908	JJ	denotes	important
T10875	2909-2915	NN	denotes	target
T10876	2916-2918	IN	denotes	of
T10877	2919-2922	NNP	denotes	Akt
T10878	2923-2925	IN	denotes	in
T10879	2926-2934	NN	denotes	lymphoma
T10880	2935-2946	NN	denotes	development
T10881	2946-2947	.	denotes	.
T10882	2948-2955	RB	denotes	However
T10883	2955-2956	,	denotes	,
T10884	2957-2968	VBG	denotes	considering
T10885	2969-2973	IN	denotes	that
T10886	2974-2977	NNP	denotes	Akt
T10887	2978-2988	NN	denotes	activation
T10888	2989-2992	VBD	denotes	did
T10889	2993-2996	RB	denotes	not
T10890	2997-3003	VB	denotes	induce
T10891	3004-3009	JJ	denotes	FoxO1
T10892	3010-3021	NN	denotes	degradation
T10893	3022-3024	IN	denotes	in
T10894	3025-3029	CD	denotes	LMP1
T10895	3030-3040	JJ	denotes	transgenic
T10896	3041-3042	NNP	denotes	B
T10897	3043-3048	NNS	denotes	cells
T10898	3048-3049	,	denotes	,
T10899	3050-3053	NNP	denotes	Akt
T10900	3054-3057	MD	denotes	may
T10901	3058-3061	RB	denotes	not
T10902	3062-3064	VB	denotes	be
T10903	3065-3068	DT	denotes	the
T10904	3069-3073	JJ	denotes	sole
T10905	3074-3083	NN	denotes	regulator
T10906	3084-3086	IN	denotes	of
T10907	3087-3092	NNP	denotes	FoxO1
T10908	3092-3093	,	denotes	,
T10909	3094-3097	CC	denotes	and
T10910	3098-3100	PRP	denotes	it
T10911	3101-3104	MD	denotes	may
T10912	3105-3107	VB	denotes	be
T10913	3108-3112	IN	denotes	that
T10914	3113-3124	NN	denotes	progression
T10915	3125-3127	TO	denotes	to
T10916	3128-3136	NN	denotes	lymphoma
T10917	3137-3145	VBZ	denotes	requires
T10918	3146-3156	NN	denotes	modulation
T10919	3157-3159	IN	denotes	of
T10920	3160-3168	JJ	denotes	multiple
T10921	3169-3177	NNS	denotes	pathways
T10922	3177-3178	.	denotes	.
T10923	3179-3182	DT	denotes	The
T10924	3183-3191	NNP	denotes	Forkhead
T10925	3192-3198	NN	denotes	family
T10926	3199-3201	IN	denotes	of
T10927	3202-3215	NN	denotes	transcription
T10928	3216-3223	NNS	denotes	factors
T10929	3224-3226	VBZ	denotes	is
T10930	3227-3232	VBN	denotes	known
T10931	3233-3235	TO	denotes	to
T10932	3236-3242	VB	denotes	induce
T10933	3243-3246	DT	denotes	the
T10934	3247-3257	NN	denotes	expression
T10935	3258-3260	IN	denotes	of
T10936	3261-3264	DT	denotes	the
T10937	3265-3268	NNP	denotes	Cdk
T10938	3269-3278	NN	denotes	inhibitor
T10939	3279-3282	CD	denotes	p27
T10940	3283-3284	NNP	denotes	[
T10941	3284-3289	CD	denotes	43,44
T10942	3289-3290	NNP	denotes	]
T10943	3290-3291	.	denotes	.
T10944	3292-3308	JJ	denotes	LMP1-transformed
T10945	3309-3315	NN	denotes	rodent
T10946	3316-3327	NNS	denotes	fibroblasts
T10947	3328-3332	VBP	denotes	have
T10948	3333-3342	VBN	denotes	decreased
T10949	3343-3353	NN	denotes	expression
T10950	3354-3356	IN	denotes	of
T10951	3357-3360	CD	denotes	p27
T10952	3360-3361	,	denotes	,
T10953	3362-3374	NN	denotes	upregulation
T10954	3375-3377	IN	denotes	of
T10955	3378-3382	NNP	denotes	Cdk2
T10956	3382-3383	,	denotes	,
T10957	3384-3387	CC	denotes	and
T10958	3388-3398	JJ	denotes	subsequent
T10959	3399-3414	NN	denotes	phosphorylation
T10960	3415-3418	CC	denotes	and
T10961	3419-3431	NN	denotes	inactivation
T10962	3432-3434	IN	denotes	of
T10963	3435-3438	DT	denotes	the
T10964	3439-3444	NN	denotes	tumor
T10965	3445-3455	NN	denotes	suppressor
T10966	3456-3460	NN	denotes	gene
T10967	3461-3463	NNP	denotes	Rb
T10968	3464-3465	NNP	denotes	[
T10969	3465-3467	CD	denotes	45
T10970	3467-3468	NNP	denotes	]
T10971	3468-3469	.	denotes	.
T10972	3470-3472	TO	denotes	To
T10973	3473-3484	VB	denotes	investigate
T10974	3485-3492	IN	denotes	whether
T10975	3493-3497	NNP	denotes	LMP1
T10976	3498-3506	VBD	denotes	affected
T10977	3507-3511	NN	denotes	cell
T10978	3512-3517	NN	denotes	cycle
T10979	3518-3528	NN	denotes	regulation
T10980	3529-3536	IN	denotes	through
T10981	3537-3540	DT	denotes	the
T10982	3541-3543	NNP	denotes	Rb
T10983	3544-3551	NN	denotes	pathway
T10984	3552-3554	IN	denotes	in
T10985	3555-3556	NNP	denotes	B
T10986	3557-3562	NNS	denotes	cells
T10987	3562-3563	,	denotes	,
T10988	3564-3574	NN	denotes	immunoblot
T10989	3575-3583	NNS	denotes	analyses
T10990	3584-3587	IN	denotes	for
T10991	3588-3591	NNP	denotes	pRb
T10992	3591-3592	,	denotes	,
T10993	3593-3597	NNP	denotes	Cdk2
T10994	3597-3598	,	denotes	,
T10995	3599-3602	CC	denotes	and
T10996	3603-3606	CD	denotes	p27
T10997	3607-3611	VBD	denotes	were
T10998	3612-3621	VBN	denotes	performed
T10999	3622-3624	IN	denotes	on
T11000	3625-3632	JJ	denotes	splenic
T11001	3633-3637	NNP	denotes	CD19
T11002	3637-3638	NNP	denotes	+
T11003	3639-3652	NNP	denotes	MACS-purified
T11004	3653-3654	NNP	denotes	B
T11005	3655-3660	NNS	denotes	cells
T11006	3660-3661	.	denotes	.
T11007	3662-3666	CD	denotes	LMP1
T11008	3667-3677	JJ	denotes	transgenic
T11009	3678-3679	NNP	denotes	B
T11010	3680-3685	NNS	denotes	cells
T11011	3686-3689	VBD	denotes	had
T11012	3690-3698	VBN	denotes	enhanced
T11013	3699-3705	NNS	denotes	levels
T11014	3706-3708	IN	denotes	of
T11015	3709-3712	NN	denotes	pRb
T11016	3713-3717	IN	denotes	with
T11017	3718-3729	JJ	denotes	concomitant
T11018	3730-3743	NN	denotes	stabilization
T11019	3744-3746	IN	denotes	of
T11020	3747-3752	JJ	denotes	total
T11021	3753-3755	NN	denotes	Rb
T11022	3756-3762	NNS	denotes	levels
T11023	3763-3766	CC	denotes	and
T11024	3767-3771	JJ	denotes	Cdk2
T11025	3772-3780	VBN	denotes	compared
T11026	3781-3783	TO	denotes	to
T11027	3784-3793	JJ	denotes	wild-type
T11028	3794-3795	NNP	denotes	B
T11029	3796-3807	NNS	denotes	lymphocytes
T11030	3808-3809	-LRB-	denotes	(
T11031	3809-3815	NN	denotes	Figure
T11032	3816-3818	NN	denotes	6C
T11033	3818-3819	-RRB-	denotes	)
T11034	3819-3820	.	denotes	.
T11035	3821-3832	NNP	denotes	Progression
T11036	3833-3835	TO	denotes	to
T11037	3836-3844	VB	denotes	lymphoma
T11038	3845-3847	IN	denotes	in
T11039	3848-3852	DT	denotes	both
T11040	3853-3862	JJ	denotes	wild-type
T11041	3863-3866	CC	denotes	and
T11042	3867-3871	JJ	denotes	LMP1
T11043	3872-3882	JJ	denotes	transgenic
T11044	3883-3891	NN	denotes	lymphoma
T11045	3892-3897	NNS	denotes	cells
T11046	3898-3901	VBD	denotes	led
T11047	3902-3904	TO	denotes	to
T11048	3905-3914	VBN	denotes	increased
T11049	3915-3921	NNS	denotes	levels
T11050	3922-3924	IN	denotes	of
T11051	3925-3927	NNP	denotes	Rb
T11052	3927-3928	,	denotes	,
T11053	3929-3944	RB	denotes	correspondingly
T11054	3945-3949	JJ	denotes	high
T11055	3950-3956	NNS	denotes	levels
T11056	3957-3959	IN	denotes	of
T11057	3960-3964	NNP	denotes	Cdk2
T11058	3964-3965	,	denotes	,
T11059	3966-3969	CC	denotes	and
T11060	3970-3979	VBD	denotes	decreased
T11061	3980-3986	NNS	denotes	levels
T11062	3987-3989	IN	denotes	of
T11063	3990-3993	CD	denotes	p27
T11064	3994-3995	-LRB-	denotes	(
T11065	3995-4001	NN	denotes	Figure
T11066	4002-4004	NN	denotes	6C
T11067	4004-4005	-RRB-	denotes	)
T11068	4005-4006	.	denotes	.
T11069	4007-4012	DT	denotes	These
T11070	4013-4017	NNS	denotes	data
T11071	4018-4026	VBP	denotes	indicate
T11072	4027-4031	IN	denotes	that
T11073	4032-4035	DT	denotes	the
T11074	4036-4038	NNP	denotes	Rb
T11075	4039-4046	NN	denotes	pathway
T11076	4047-4049	VBZ	denotes	is
T11077	4050-4061	VBN	denotes	deregulated
T11078	4062-4064	IN	denotes	in
T11079	4065-4069	CD	denotes	LMP1
T11080	4070-4080	JJ	denotes	transgenic
T11081	4081-4092	NNS	denotes	lymphocytes
T11082	4093-4096	CC	denotes	and
T11083	4097-4101	IN	denotes	that
T11084	4102-4110	NN	denotes	lymphoma
T11085	4111-4116	NNS	denotes	cells
T11086	4117-4120	VBP	denotes	are
T11087	4121-4134	VBN	denotes	distinguished
T11088	4135-4137	IN	denotes	by
T11089	4138-4142	NN	denotes	loss
T11090	4143-4145	IN	denotes	of
T11091	4146-4151	NNP	denotes	FoxO1
T11092	4152-4155	CC	denotes	and
T11093	4156-4165	VBD	denotes	decreased
T11094	4166-4169	CD	denotes	p27
T11095	4169-4170	.	denotes	.
T24520	1324-1328	CD	denotes	LMP1
T24521	1329-1338	NNP	denotes	Activates
T24522	1339-1342	NNP	denotes	Akt
T24523	1343-1352	VBG	denotes	Signaling
T24524	1353-1356	CC	denotes	and
T24525	1357-1368	VBZ	denotes	Deregulates
T24526	1369-1372	DT	denotes	the
T24527	1373-1375	NNP	denotes	Rb
T24528	1376-1380	NNP	denotes	Cell
T24529	1381-1386	NNP	denotes	Cycle
T24530	1387-1394	NNP	denotes	Pathway
T24531	1395-1396	-LRB-	denotes	(
T24532	1396-1397	DT	denotes	A
T24533	1398-1401	CC	denotes	and
T24534	1402-1403	NNP	denotes	B
T24535	1403-1404	-RRB-	denotes	)
T24536	1405-1415	NNP	denotes	Immunoblot
T24537	1416-1424	NN	denotes	analysis
T24538	1425-1427	IN	denotes	of
T24539	1428-1436	VBN	denotes	purified
T24540	1437-1438	NNP	denotes	B
T24541	1439-1444	NNS	denotes	cells
T24542	1445-1446	-LRB-	denotes	(
T24543	1446-1450	CD	denotes	CD19
T24544	1450-1451	NN	denotes	+
T24545	1451-1452	-RRB-	denotes	)
T24546	1453-1457	IN	denotes	from
T24547	1458-1461	DT	denotes	the
T24548	1462-1469	NNS	denotes	spleens
T24549	1470-1472	IN	denotes	of
T24550	1473-1475	NNP	denotes	WT
T24551	1476-1479	CC	denotes	and
T24552	1480-1484	NNP	denotes	LMP1
T24553	1485-1495	JJ	denotes	transgenic
T24554	1496-1500	NNS	denotes	mice
T24555	1501-1504	IN	denotes	for
T24556	1505-1508	NNP	denotes	Akt
T24557	1509-1518	VBG	denotes	signaling
T24558	1518-1519	,	denotes	,
T24559	1520-1527	VBG	denotes	probing
T24560	1528-1531	IN	denotes	for
T24561	1532-1533	-LRB-	denotes	(
T24562	1533-1534	NN	denotes	A
T24563	1534-1535	-RRB-	denotes	)
T24564	1536-1545	VBN	denotes	activated
T24565	1546-1550	NNP	denotes	pAkt
T24566	1551-1554	CC	denotes	and
T24567	1555-1565	JJ	denotes	downstream
T24568	1566-1573	NNS	denotes	targets
T24569	1573-1574	,	denotes	,
T24570	1575-1584	VBG	denotes	including
T24571	1585-1596	JJ	denotes	inactivated
T24572	1597-1603	JJ	denotes	pGSK3α
T24573	1603-1604	NN	denotes	/
T24574	1604-1605	NN	denotes	β
T24575	1605-1606	,	denotes	,
T24576	1607-1610	CC	denotes	and
T24577	1611-1612	-LRB-	denotes	(
T24578	1612-1613	NNP	denotes	B
T24579	1613-1614	-RRB-	denotes	)
T24580	1615-1624	VBD	denotes	activated
T24581	1625-1631	NNP	denotes	p-mTOR
T24582	1631-1632	,	denotes	,
T24583	1633-1636	CC	denotes	and
T24584	1637-1642	JJ	denotes	total
T24585	1643-1649	NNS	denotes	levels
T24586	1650-1652	IN	denotes	of
T24587	1653-1658	NNP	denotes	FoxO1
T24588	1658-1659	.	denotes	.
T24589	1660-1666	NNS	denotes	Arrows
T24590	1667-1675	VBP	denotes	indicate
T24591	1676-1679	DT	denotes	the
T24592	1680-1689	NNS	denotes	positions
T24593	1690-1692	IN	denotes	of
T24594	1693-1694	NN	denotes	α
T24595	1695-1698	CC	denotes	and
T24596	1699-1700	NN	denotes	β
T24597	1701-1709	NNS	denotes	isoforms
T24598	1710-1712	IN	denotes	of
T24599	1713-1717	NNP	denotes	GSK3
T24600	1717-1718	.	denotes	.
T24601	1719-1722	DT	denotes	The
T24602	1723-1728	JJ	denotes	white
T24603	1729-1733	NN	denotes	line
T24604	1734-1743	VBZ	denotes	indicates
T24605	1744-1748	IN	denotes	that
T24606	1749-1760	VBG	denotes	intervening
T24607	1761-1766	NNS	denotes	lanes
T24608	1767-1771	VBP	denotes	have
T24609	1772-1776	VBN	denotes	been
T24610	1777-1784	VBN	denotes	spliced
T24611	1785-1788	RP	denotes	out
T24612	1788-1789	.	denotes	.
T24613	1790-1791	-LRB-	denotes	(
T24614	1791-1792	NNP	denotes	C
T24615	1792-1793	-RRB-	denotes	)
T24616	1794-1804	NNP	denotes	Immunoblot
T24617	1805-1813	NN	denotes	analysis
T24618	1814-1817	IN	denotes	for
T24619	1818-1822	NN	denotes	cell
T24620	1823-1828	NN	denotes	cycle
T24621	1829-1837	NNS	denotes	proteins
T24622	1838-1848	VBG	denotes	regulating
T24623	1849-1852	DT	denotes	the
T24624	1853-1855	NNP	denotes	Rb
T24625	1856-1863	NN	denotes	pathway
T24626	1863-1864	,	denotes	,
T24627	1865-1872	VBG	denotes	probing
T24628	1873-1876	IN	denotes	for
T24629	1877-1886	VBN	denotes	activated
T24630	1887-1890	NNP	denotes	pRb
T24631	1890-1891	,	denotes	,
T24632	1892-1895	CC	denotes	and
T24633	1896-1901	JJ	denotes	total
T24634	1902-1908	NNS	denotes	levels
T24635	1909-1911	IN	denotes	of
T24636	1912-1916	NNP	denotes	Cdk2
T24637	1917-1920	CC	denotes	and
T24638	1921-1924	DT	denotes	the
T24639	1925-1928	NNP	denotes	Cdk
T24640	1929-1938	NN	denotes	inhibitor
T24641	1939-1942	NN	denotes	p27
T24642	1942-1943	.	denotes	.
T24643	1944-1949	NNP	denotes	Actin
T24644	1950-1953	VBD	denotes	was
T24645	1954-1958	VBN	denotes	used
T24646	1959-1961	IN	denotes	as
T24647	1962-1963	DT	denotes	a
T24648	1964-1971	VBG	denotes	loading
T24649	1972-1979	NN	denotes	control
T24650	1979-1980	.	denotes	.
R7982	T10502	T10507	nummod	LMP1,Deregulates
R7983	T10503	T10504	compound	Activates,Akt
R7984	T10504	T10507	compound	Akt,Deregulates
R7985	T10505	T10507	amod	Signaling,Deregulates
R7986	T10506	T10505	cc	and,Signaling
R7987	T10507	T10507	ROOT	Deregulates,Deregulates
R7988	T10508	T10514	det	the,transformation
R7989	T10509	T10511	compound	Rb,Cycle
R7990	T10510	T10511	compound	Cell,Cycle
R7991	T10511	T10512	compound	Cycle,Pathway
R7992	T10512	T10513	compound	Pathway,LMP1
R7993	T10513	T10514	compound	LMP1,transformation
R7994	T10514	T10507	dobj	transformation,Deregulates
R7995	T10515	T10514	prep	of,transformation
R7996	T10516	T10517	compound	rodent,fibroblasts
R7997	T10517	T10515	pobj	fibroblasts,of
R7998	T10518	T10507	conj	requires,Deregulates
R7999	T10519	T10518	dobj	activation,requires
R8000	T10520	T10519	prep	of,activation
R8001	T10521	T10520	pobj	PI3K,of
R8002	T10522	T10521	cc	and,PI3K
R8003	T10523	T10524	compound	Akt,[
R8004	T10524	T10507	appos	[,Deregulates
R8005	T10525	T10526	nummod	5,]
R8006	T10526	T10524	appos	],[
R8007	T10527	T10507	punct	.,Deregulates
R8008	T10528	T10534	advmod	Additionally,detected
R8009	T10529	T10534	punct	",",detected
R8010	T10530	T10531	amod	activated,pAkt
R8011	T10531	T10534	nsubjpass	pAkt,detected
R8012	T10532	T10534	auxpass	is,detected
R8013	T10533	T10534	advmod	frequently,detected
R8014	T10534	T10534	ROOT	detected,detected
R8015	T10535	T10534	prep	in,detected
R8016	T10536	T10535	pobj	NPC,in
R8017	T10537	T10536	cc	and,NPC
R8018	T10538	T10541	det	the,cells
R8019	T10539	T10541	amod	neoplastic,cells
R8020	T10540	T10541	compound	Reed-Sternberg,cells
R8021	T10541	T10536	conj	cells,NPC
R8022	T10542	T10541	prep	of,cells
R8023	T10543	T10545	amod	classical,[
R8024	T10544	T10545	compound	HD,[
R8025	T10545	T10542	pobj	[,of
R8026	T10546	T10547	nummod	"39,40",]
R8027	T10547	T10541	conj	],cells
R8028	T10548	T10534	punct	.,detected
R8029	T10549	T10550	aux	To,determine
R8030	T10550	T10550	ROOT	determine,determine
R8031	T10551	T10553	mark	if,signaling
R8032	T10552	T10553	compound	Akt,signaling
R8033	T10553	T10555	nsubjpass	signaling,activated
R8034	T10554	T10555	auxpass	is,activated
R8035	T10555	T10550	ccomp	activated,determine
R8036	T10556	T10555	prep	in,activated
R8037	T10557	T10559	nummod	LMP1,mice
R8038	T10558	T10559	amod	transgenic,mice
R8039	T10559	T10556	pobj	mice,in
R8040	T10560	T10559	punct	",",mice
R8041	T10561	T10568	nsubjpass	pAkt,assessed
R8042	T10562	T10561	cc	and,pAkt
R8043	T10563	T10561	conj	several,pAkt
R8044	T10564	T10563	prep	of,several
R8045	T10565	T10566	poss	its,targets
R8046	T10566	T10564	pobj	targets,of
R8047	T10567	T10568	auxpass	were,assessed
R8048	T10568	T10555	advcl	assessed,activated
R8049	T10569	T10568	agent	by,assessed
R8050	T10570	T10569	pobj	immunoblotting,by
R8051	T10571	T10570	prep	of,immunoblotting
R8052	T10572	T10577	amod	splenic,cells
R8053	T10573	T10576	compound	CD19,B
R8054	T10574	T10576	compound	+,B
R8055	T10575	T10576	compound	MACS-purified,B
R8056	T10576	T10577	compound	B,cells
R8057	T10577	T10571	pobj	cells,of
R8058	T10578	T10550	punct	.,determine
R8059	T10579	T10582	nummod	LMP1,cells
R8060	T10580	T10582	amod	transgenic,cells
R8061	T10581	T10582	compound	B,cells
R8062	T10582	T10584	nsubj	cells,increased
R8063	T10583	T10584	aux	had,increased
R8064	T10584	T10609	ccomp	increased,increase
R8065	T10585	T10584	dobj	levels,increased
R8066	T10586	T10585	prep	of,levels
R8067	T10587	T10586	pobj	pAkt,of
R8068	T10588	T10584	prep	compared,increased
R8069	T10589	T10588	prep	to,compared
R8070	T10590	T10591	compound	wild-type,lymphocytes
R8071	T10591	T10589	pobj	lymphocytes,to
R8072	T10592	T10609	punct	;,increase
R8073	T10593	T10609	advmod	however,increase
R8074	T10594	T10593	punct	",",however
R8075	T10595	T10609	nsubj	progression,increase
R8076	T10596	T10609	prep	to,increase
R8077	T10597	T10596	pobj	lymphoma,to
R8078	T10598	T10597	prep	in,lymphoma
R8079	T10599	T10600	det	both,LMP1-positive
R8080	T10600	T10598	pobj	LMP1-positive,in
R8081	T10601	T10600	cc	and,LMP1-positive
R8082	T10602	T10603	punct	-,negative
R8083	T10603	T10605	amod	negative,cells
R8084	T10604	T10605	compound	lymphoma,cells
R8085	T10605	T10609	nsubj	cells,increase
R8086	T10606	T10609	aux	did,increase
R8087	T10607	T10608	neg	not,further
R8088	T10608	T10609	advmod	further,increase
R8089	T10609	T10609	ROOT	increase,increase
R8090	T10610	T10611	compound	pAkt,levels
R8091	T10611	T10609	dobj	levels,increase
R8092	T10612	T10609	punct	.,increase
R8093	T10613	T10624	det	The,inactivated
R8094	T10614	T10624	nsubjpass	Akt,inactivated
R8095	T10615	T10616	compound	target,glycogen
R8096	T10616	T10624	nsubjpass	glycogen,inactivated
R8097	T10617	T10618	compound	synthase,kinase
R8098	T10618	T10616	appos	kinase,glycogen
R8099	T10619	T10618	nummod	3,kinase
R8100	T10620	T10621	punct	(,GSK3
R8101	T10621	T10618	appos	GSK3,kinase
R8102	T10622	T10618	punct	),kinase
R8103	T10623	T10624	auxpass	is,inactivated
R8104	T10624	T10630	ccomp	inactivated,increased
R8105	T10625	T10624	agent	by,inactivated
R8106	T10626	T10625	pobj	phosphorylation,by
R8107	T10627	T10630	punct	;,increased
R8108	T10628	T10630	advmod	however,increased
R8109	T10629	T10630	punct	",",increased
R8110	T10630	T10630	ROOT	increased,increased
R8111	T10631	T10632	compound	phosphorylated,GSK3
R8112	T10632	T10635	nsubjpass	GSK3,detected
R8113	T10633	T10635	auxpass	was,detected
R8114	T10634	T10635	neg	not,detected
R8115	T10635	T10630	ccomp	detected,increased
R8116	T10636	T10635	prep	in,detected
R8117	T10637	T10639	det	the,lymphocytes
R8133	T10653	T10654	det	This,finding
R8134	T10654	T10655	nsubj	finding,indicates
R8135	T10655	T10655	ROOT	indicates,indicates
R8136	T10656	T10658	mark	that,is
R8137	T10657	T10658	nsubj	GSK3,is
R8138	T10658	T10655	ccomp	is,indicates
R8139	T10659	T10658	neg	not,is
R8140	T10660	T10661	det	a,target
R8141	T10661	T10658	attr	target,is
R8142	T10662	T10661	prep	of,target
R8143	T10663	T10664	amod	activated,Akt
R8144	T10664	T10662	pobj	Akt,of
R8145	T10665	T10664	prep	in,Akt
R8146	T10666	T10669	det	the,lymphocytes
R8147	T10667	T10669	compound	LMP1,lymphocytes
R8148	T10668	T10669	compound	transgenic,lymphocytes
R8149	T10669	T10665	pobj	lymphocytes,in
R8150	T10670	T10669	cc	and,lymphocytes
R8151	T10671	T10672	compound	lymphoma,cells
R8152	T10672	T10669	conj	cells,lymphocytes
R8153	T10673	T10655	punct	.,indicates
R8154	T10674	T10686	advmod	Similarly,shown
R8155	T10675	T10686	punct	",",shown
R8156	T10676	T10686	nsubjpass	activation,shown
R8157	T10677	T10676	prep	of,activation
R8158	T10678	T10677	pobj	Akt,of
R8159	T10679	T10676	prep	without,activation
R8160	T10680	T10679	pobj	phosphorylation,without
R8161	T10681	T10680	prep	of,phosphorylation
R8162	T10682	T10681	pobj	GSK3,of
R8163	T10683	T10686	aux	has,shown
R8164	T10684	T10686	auxpass	been,shown
R8165	T10685	T10686	advmod	previously,shown
R8166	T10686	T10686	ROOT	shown,shown
R8167	T10687	T10686	prep	in,shown
R8168	T10688	T10690	amod	EBV-positive,[
R8169	T10689	T10690	compound	HD,[
R8170	T10690	T10687	pobj	[,in
R8171	T10691	T10692	nummod	40,]
R8172	T10692	T10686	dobj	],shown
R8173	T10693	T10686	punct	.,shown
R8174	T10694	T10700	prep	In,lacked
R8175	T10695	T10694	pobj	contrast,In
R8176	T10696	T10700	punct	",",lacked
R8177	T10697	T10699	det	the,lymphocytes
R8178	T10698	T10699	amod	wild-type,lymphocytes
R8179	T10699	T10700	nsubj	lymphocytes,lacked
R8180	T10700	T10700	ROOT	lacked,lacked
R8181	T10701	T10700	conj	activated,lacked
R8183	T10703	T10701	cc	but,activated
R8184	T10704	T10705	aux	did,have
R8185	T10705	T10701	conj	have,activated
R8186	T10706	T10708	amod	detectable,GSK3
R8187	T10707	T10708	compound	phosphorylated,GSK3
R8188	T10708	T10705	dobj	GSK3,have
R8189	T10709	T10700	punct	.,lacked
R8190	T10710	T10712	nsubj	This,suggests
R8191	T10711	T10712	advmod	further,suggests
R8192	T10712	T10712	ROOT	suggests,suggests
R8193	T10713	T10717	mark	that,involved
R8194	T10714	T10715	amod	additional,pathways
R8195	T10715	T10717	nsubjpass	pathways,involved
R8196	T10716	T10717	auxpass	are,involved
R8197	T10717	T10712	ccomp	involved,suggests
R8198	T10718	T10717	prep	in,involved
R8199	T10719	T10720	det	the,regulation
R8200	T10720	T10718	pobj	regulation,in
R8201	T10721	T10720	prep	of,regulation
R8202	T10722	T10721	pobj	GSK3,of
R8203	T10723	T10712	punct	.,suggests
R8204	T10724	T10725	aux	To,identify
R8205	T10725	T10736	advcl	identify,performed
R8206	T10726	T10729	amod	other,targets
R8207	T10727	T10729	amod	potential,targets
R8208	T10728	T10729	compound	Akt,targets
R8209	T10729	T10725	dobj	targets,identify
R8210	T10730	T10729	punct	",",targets
R8211	T10731	T10732	compound	immunoblot,analysis
R8212	T10732	T10736	nsubjpass	analysis,performed
R8213	T10733	T10732	prep	for,analysis
R8214	T10734	T10733	pobj	p-mTOR,for
R8215	T10735	T10736	auxpass	was,performed
R8216	T10736	T10736	ROOT	performed,performed
R8217	T10737	T10736	punct	.,performed
R8218	T10738	T10739	amod	Activated,p-mTOR
R8219	T10739	T10742	nsubjpass	p-mTOR,increased
R8220	T10740	T10742	auxpass	was,increased
R8221	T10741	T10742	neg	not,increased
R8222	T10742	T10742	ROOT	increased,increased
R8223	T10743	T10742	prep	in,increased
R8224	T10744	T10746	nummod	LMP1,lymphocytes
R8225	T10745	T10746	amod	transgenic,lymphocytes
R8226	T10746	T10743	pobj	lymphocytes,in
R8227	T10747	T10746	cc	or,lymphocytes
R8228	T10748	T10749	compound	lymphoma,cells
R8229	T10749	T10746	conj	cells,lymphocytes
R8230	T10750	T10742	punct	",",increased
R8231	T10751	T10742	advcl	indicating,increased
R8232	T10752	T10757	mark	that,affected
R8233	T10753	T10754	det	this,pathway
R8234	T10754	T10757	nsubjpass	pathway,affected
R8235	T10755	T10757	auxpass	is,affected
R8236	T10756	T10757	neg	not,affected
R8237	T10757	T10751	ccomp	affected,indicating
R8238	T10758	T10757	agent	by,affected
R8239	T10759	T10761	amod	LMP1-induced,activation
R8240	T10760	T10761	compound	Akt,activation
R8241	T10761	T10758	pobj	activation,by
R8242	T10762	T10757	cc	and,affected
R8243	T10763	T10765	aux	does,contribute
R8244	T10764	T10765	neg	not,contribute
R8245	T10765	T10757	conj	contribute,affected
R8246	T10766	T10765	prep	to,contribute
R8247	T10767	T10768	compound	lymphoma,development
R8248	T10768	T10766	pobj	development,to
R8249	T10769	T10771	punct	(,6B
R8250	T10770	T10771	compound	Figure,6B
R8251	T10771	T10768	appos	6B,development
R8252	T10772	T10771	punct	),6B
R8253	T10773	T10742	punct	.,increased
R8254	T10774	T10777	nsubjpass	Akt,known
R8255	T10775	T10777	auxpass	is,known
R8256	T10776	T10777	advmod	also,known
R8257	T10777	T10777	ROOT	known,known
R8258	T10778	T10779	aux	to,phosphorylate
R8259	T10779	T10777	xcomp	phosphorylate,known
R8260	T10780	T10779	cc	and,phosphorylate
R8261	T10781	T10779	conj	induce,phosphorylate
R8262	T10782	T10783	det	the,degradation
R8263	T10783	T10781	dobj	degradation,induce
R8264	T10784	T10783	prep	of,degradation
R8265	T10785	T10788	det	the,family
R8266	T10786	T10788	amod	pro-apoptotic,family
R8267	T10787	T10788	compound	Forkhead,family
R8268	T10788	T10784	pobj	family,of
R8269	T10789	T10788	prep	of,family
R8270	T10790	T10791	compound	transcription,factors
R8271	T10791	T10789	pobj	factors,of
R8272	T10792	T10781	punct	",",induce
R8273	T10793	T10781	advcl	leading,induce
R8274	T10794	T10793	prep	to,leading
R8275	T10795	T10796	compound	cell,cycle
R8276	T10796	T10797	compound	cycle,progression
R8277	T10797	T10794	pobj	progression,to
R8278	T10798	T10797	cc	and,progression
R8279	T10799	T10797	conj	survival,progression
R8280	T10800	T10793	prep	in,leading
R8281	T10801	T10803	det	some,tumors
R8282	T10802	T10803	amod	human,tumors
R8283	T10803	T10800	pobj	tumors,in
R8284	T10804	T10806	compound	[,]
R8285	T10805	T10806	compound	"41,42",]
R8286	T10806	T10806	ROOT	],]
R8287	T10807	T10777	punct	.,known
R8288	T10808	T10809	compound	Immunoblot,analysis
R8289	T10809	T10817	nsubj	analysis,detect
R8290	T10810	T10809	prep	of,analysis
R8291	T10811	T10813	amod	splenic,cells
R8292	T10812	T10813	compound	B,cells
R8293	T10813	T10810	pobj	cells,of
R8294	T10814	T10817	aux	did,detect
R8295	T10815	T10817	neg	not,detect
R8296	T10816	T10817	advmod	consistently,detect
R8297	T10817	T10817	ROOT	detect,detect
R8298	T10818	T10819	amod	p-FoxO1,levels
R8299	T10819	T10817	dobj	levels,detect
R8300	T10820	T10817	punct	",",detect
R8301	T10821	T10822	det	a,signal
R8302	T10822	T10817	dobj	signal,detect
R8303	T10823	T10824	nsubj	that,targets
R8304	T10824	T10822	relcl	targets,signal
R8305	T10825	T10824	dobj	FoxO1,targets
R8306	T10826	T10824	prep	for,targets
R8307	T10827	T10826	pobj	degradation,for
R8308	T10828	T10817	punct	.,detect
R8309	T10829	T10835	advmod	Hence,assessed
R8310	T10830	T10835	punct	",",assessed
R8311	T10831	T10835	nsubjpass	degradation,assessed
R8312	T10832	T10831	prep	of,degradation
R8313	T10833	T10832	pobj	FoxO1,of
R8314	T10834	T10835	auxpass	was,assessed
R8315	T10835	T10835	ROOT	assessed,assessed
R8316	T10836	T10835	agent	by,assessed
R8317	T10837	T10836	pobj	detection,by
R8318	T10838	T10837	prep	of,detection
R8319	T10839	T10841	amod	total,levels
R8320	T10840	T10841	amod	FoxO1,levels
R8321	T10841	T10838	pobj	levels,of
R8322	T10842	T10835	punct	.,assessed
R8323	T10843	T10844	compound	Immunoblot,analysis
R8324	T10844	T10845	nsubj	analysis,indicated
R8325	T10845	T10845	ROOT	indicated,indicated
R8326	T10846	T10852	mark	that,decreased
R8327	T10847	T10849	amod	total,levels
R8328	T10848	T10849	amod	FoxO1,levels
R8329	T10849	T10852	nsubjpass	levels,decreased
R8330	T10850	T10852	auxpass	were,decreased
R8331	T10851	T10852	advmod	greatly,decreased
R8332	T10852	T10845	ccomp	decreased,indicated
R8333	T10853	T10852	prep	in,decreased
R8334	T10854	T10858	nmod	wild-type,lymphomas
R8335	T10855	T10854	cc	and,wild-type
R8336	T10856	T10854	conj	LMP1,wild-type
R8337	T10857	T10858	amod	transgenic,lymphomas
R8338	T10858	T10853	pobj	lymphomas,in
R8339	T10859	T10861	punct	(,6B
R8340	T10860	T10861	compound	Figure,6B
R8341	T10861	T10858	appos	6B,lymphomas
R8342	T10862	T10858	punct	),lymphomas
R8343	T10863	T10852	punct	",",decreased
R8344	T10864	T10852	advcl	suggesting,decreased
R8345	T10865	T10872	mark	that,is
R8346	T10866	T10872	nsubj	inhibition,is
R8347	T10867	T10866	prep	of,inhibition
R8348	T10868	T10869	det	the,Forkhead
R8349	T10869	T10867	pobj	Forkhead,of
R8350	T10870	T10872	csubj	signaling,is
R8392	T10912	T10902	conj	be,be
R8393	T10913	T10914	det	that,progression
R8394	T10914	T10912	attr	progression,be
R8395	T10915	T10916	aux	to,lymphoma
R8396	T10916	T10917	nsubj	lymphoma,requires
R8397	T10917	T10912	advcl	requires,be
R8398	T10918	T10917	dobj	modulation,requires
R8399	T10919	T10918	prep	of,modulation
R8400	T10920	T10921	amod	multiple,pathways
R8401	T10921	T10919	pobj	pathways,of
R8402	T10922	T10917	punct	.,requires
R8403	T10923	T10925	det	The,family
R8404	T10924	T10925	compound	Forkhead,family
R8405	T10925	T10930	nsubjpass	family,known
R8406	T10926	T10925	prep	of,family
R8407	T10927	T10928	compound	transcription,factors
R8408	T10928	T10926	pobj	factors,of
R8409	T10929	T10930	auxpass	is,known
R8410	T10930	T10930	ROOT	known,known
R8411	T10931	T10932	aux	to,induce
R8412	T10932	T10930	xcomp	induce,known
R8413	T10933	T10934	det	the,expression
R8414	T10934	T10932	dobj	expression,induce
R8415	T10935	T10934	prep	of,expression
R8416	T10936	T10938	det	the,inhibitor
R8417	T10937	T10938	compound	Cdk,inhibitor
R8418	T10938	T10935	pobj	inhibitor,of
R8419	T10939	T10942	nummod	p27,]
R8420	T10940	T10942	nmod	[,]
R8421	T10941	T10942	nummod	"43,44",]
R8422	T10942	T10938	appos	],inhibitor
R8423	T10943	T10930	punct	.,known
R8424	T10944	T10946	amod	LMP1-transformed,fibroblasts
R8425	T10945	T10946	compound	rodent,fibroblasts
R8426	T10946	T10948	nsubj	fibroblasts,decreased
R8427	T10947	T10948	aux	have,decreased
R8428	T10948	T10948	ROOT	decreased,decreased
R8429	T10949	T10948	dobj	expression,decreased
R8451	T10971	T10948	punct	.,decreased
R8452	T10972	T10973	aux	To,investigate
R8453	T10973	T10998	advcl	investigate,performed
R8454	T10974	T10976	mark	whether,affected
R8455	T10975	T10976	nsubj	LMP1,affected
R8456	T10976	T10998	advcl	affected,performed
R8457	T10977	T10978	compound	cell,cycle
R8458	T10978	T10979	compound	cycle,regulation
R8459	T10979	T10976	dobj	regulation,affected
R8460	T10980	T10976	prep	through,affected
R8461	T10981	T10983	det	the,pathway
R8462	T10982	T10983	compound	Rb,pathway
R8463	T10983	T10980	pobj	pathway,through
R8464	T10984	T10983	prep	in,pathway
R8465	T10985	T10986	compound	B,cells
R8466	T10986	T10984	pobj	cells,in
R8467	T10987	T10983	punct	",",pathway
R8468	T10988	T10989	compound	immunoblot,analyses
R8469	T10989	T10976	advcl	analyses,affected
R8470	T10990	T10989	prep	for,analyses
R8471	T10991	T10990	pobj	pRb,for
R8472	T10992	T10991	punct	",",pRb
R8473	T10993	T10991	conj	Cdk2,pRb
R8474	T10994	T10993	punct	",",Cdk2
R8475	T10995	T10989	cc	and,analyses
R8476	T10996	T10998	nsubjpass	p27,performed
R8477	T10997	T10998	auxpass	were,performed
R8478	T10998	T10998	ROOT	performed,performed
R8479	T10999	T10998	prep	on,performed
R8480	T11000	T11001	compound	splenic,CD19
R8481	T11001	T10999	pobj	CD19,on
R8482	T11002	T11004	compound	+,B
R8483	T11003	T11004	compound	MACS-purified,B
R8484	T11004	T11005	compound	B,cells
R8485	T11005	T10998	dobj	cells,performed
R8486	T11006	T10998	punct	.,performed
R8487	T11007	T11010	nummod	LMP1,cells
R8488	T11008	T11010	amod	transgenic,cells
R8489	T11009	T11010	compound	B,cells
R8490	T11010	T11012	nsubj	cells,enhanced
R8491	T11011	T11012	aux	had,enhanced
R8492	T11012	T11012	ROOT	enhanced,enhanced
R8493	T11013	T11012	dobj	levels,enhanced
R8494	T11014	T11013	prep	of,levels
R8495	T11015	T11014	pobj	pRb,of
R8496	T11016	T11013	prep	with,levels
R8497	T11017	T11018	amod	concomitant,stabilization
R8498	T11018	T11016	pobj	stabilization,with
R8499	T11019	T11018	prep	of,stabilization
R8500	T11020	T11022	amod	total,levels
R8501	T11021	T11022	compound	Rb,levels
R8502	T11022	T11019	pobj	levels,of
R8503	T11023	T11022	cc	and,levels
R8504	T11024	T11022	conj	Cdk2,levels
R8505	T11025	T11012	prep	compared,enhanced
R8506	T11026	T11025	prep	to,compared
R8507	T11027	T11029	amod	wild-type,lymphocytes
R8508	T11028	T11029	compound	B,lymphocytes
R8509	T11029	T11026	pobj	lymphocytes,to
R8510	T11030	T11032	punct	(,6C
R8511	T11031	T11032	compound	Figure,6C
R8512	T11032	T11029	appos	6C,lymphocytes
R8513	T11033	T11032	punct	),6C
R8514	T11034	T11012	punct	.,enhanced
R8515	T11035	T11046	nsubj	Progression,led
R8516	T11036	T11037	aux	to,lymphoma
R8517	T11037	T11035	xcomp	lymphoma,Progression
R8518	T11038	T11037	prep	in,lymphoma
R8519	T11039	T11040	preconj	both,wild-type
R8520	T11040	T11045	amod	wild-type,cells
R8521	T11041	T11040	cc	and,wild-type
R8522	T11042	T11040	conj	LMP1,wild-type
R8523	T11043	T11045	amod	transgenic,cells
R8524	T11044	T11045	compound	lymphoma,cells
R8525	T11045	T11038	pobj	cells,in
R8526	T11046	T11046	ROOT	led,led
R8527	T11047	T11046	prep	to,led
R8528	T11048	T11049	amod	increased,levels
R8529	T11049	T11047	pobj	levels,to
R8530	T11050	T11049	prep	of,levels
R8531	T11051	T11050	pobj	Rb,of
R8532	T11052	T11049	punct	",",levels
R8533	T11053	T11054	advmod	correspondingly,high
R8534	T11054	T11055	amod	high,levels
R8535	T11055	T11049	conj	levels,levels
R8536	T11056	T11055	prep	of,levels
R8537	T11057	T11056	pobj	Cdk2,of
R8538	T11058	T11055	punct	",",levels
R8539	T11059	T11055	cc	and,levels
R8540	T11060	T11061	amod	decreased,levels
R8541	T11061	T11055	conj	levels,levels
R8542	T11062	T11061	prep	of,levels
R8543	T11063	T11062	pobj	p27,of
R8544	T11064	T11066	punct	(,6C
R8545	T11065	T11066	compound	Figure,6C
R8546	T11066	T11061	appos	6C,levels
R8547	T11067	T11066	punct	),6C
R8548	T11068	T11046	punct	.,led
R8549	T11069	T11070	det	These,data
R8550	T11070	T11071	nsubj	data,indicate
R8551	T11071	T11071	ROOT	indicate,indicate
R8552	T11072	T11077	mark	that,deregulated
R8553	T11073	T11075	det	the,pathway
R8554	T11074	T11075	compound	Rb,pathway
R8555	T11075	T11077	nsubjpass	pathway,deregulated
R8556	T11076	T11077	auxpass	is,deregulated
R8557	T11077	T11071	ccomp	deregulated,indicate
R8558	T11078	T11077	prep	in,deregulated
R8559	T11079	T11081	nummod	LMP1,lymphocytes
R8560	T11080	T11081	amod	transgenic,lymphocytes
R8561	T11081	T11078	pobj	lymphocytes,in
R8562	T11082	T11077	cc	and,deregulated
R8563	T11083	T11087	mark	that,distinguished
R8564	T11084	T11085	compound	lymphoma,cells
R8565	T11085	T11087	nsubjpass	cells,distinguished
R8566	T11086	T11087	auxpass	are,distinguished
R8567	T11087	T11077	conj	distinguished,deregulated
R8568	T11088	T11087	agent	by,distinguished
R8569	T11089	T11088	pobj	loss,by
R8570	T11090	T11089	prep	of,loss
R8571	T11091	T11090	pobj	FoxO1,of
R8572	T11092	T11087	cc	and,distinguished
R8573	T11093	T11087	conj	decreased,distinguished
R8574	T11094	T11093	dobj	p27,decreased
R8575	T11095	T11071	punct	.,indicate
R19079	T24535	T24534	punct	),B
R19080	T24536	T24537	compound	Immunoblot,analysis
R19081	T24537	T24564	nsubj	analysis,activated
R19082	T24538	T24537	prep	of,analysis
R19083	T24539	T24541	amod	purified,cells
R19084	T24540	T24541	compound	B,cells
R19085	T24541	T24538	pobj	cells,of
R19086	T24542	T24541	punct	(,cells
R19087	T24543	T24544	nummod	CD19,+
R19088	T24544	T24541	appos	+,cells
R19089	T24545	T24541	punct	),cells
R19090	T24546	T24537	prep	from,analysis
R19091	T24547	T24548	det	the,spleens
R19092	T24548	T24546	pobj	spleens,from
R19093	T24549	T24548	prep	of,spleens
R19094	T24550	T24549	pobj	WT,of
R19095	T24551	T24550	cc	and,WT
R19096	T24552	T24550	conj	LMP1,WT
R19097	T24553	T24554	amod	transgenic,mice
R19098	T24554	T24548	conj	mice,spleens
R19099	T24555	T24537	prep	for,analysis
R19100	T24556	T24557	compound	Akt,signaling
R19101	T24557	T24555	pcomp	signaling,for
R19102	T24558	T24557	punct	",",signaling
R19103	T24559	T24557	conj	probing,signaling
R19104	T24560	T24559	prep	for,probing
R19105	T24561	T24562	punct	(,A
R19106	T24562	T24560	pobj	A,for
R19107	T24563	T24562	punct	),A
R19108	T24564	T24564	ROOT	activated,activated
R19109	T24565	T24564	dobj	pAkt,activated
R19110	T24566	T24565	cc	and,pAkt
R19111	T24567	T24568	amod	downstream,targets
R19112	T24568	T24565	conj	targets,pAkt
R19113	T24569	T24568	punct	",",targets
R19114	T24570	T24568	prep	including,targets
R19115	T24571	T24574	amod	inactivated,β
R19116	T24572	T24574	amod	pGSK3α,β
R19117	T24573	T24574	compound	/,β
R19118	T24574	T24570	pobj	β,including
R19119	T24575	T24568	punct	",",targets
R19120	T24576	T24568	cc	and,targets
R19121	T24577	T24578	punct	(,B
R19122	T24578	T24568	conj	B,targets
R19123	T24579	T24564	punct	),activated
R19124	T24580	T24580	ROOT	activated,activated
R19125	T24581	T24580	dobj	p-mTOR,activated
R19126	T24582	T24581	punct	",",p-mTOR
R19127	T24583	T24581	cc	and,p-mTOR
R19128	T24584	T24585	amod	total,levels
R19129	T24585	T24581	conj	levels,p-mTOR
R19130	T24586	T24585	prep	of,levels
R19131	T24587	T24586	pobj	FoxO1,of
R19132	T24588	T24580	punct	.,activated
R19133	T24589	T24590	nsubj	Arrows,indicate
R19134	T24590	T24590	ROOT	indicate,indicate
R19135	T24591	T24592	det	the,positions
R19136	T24592	T24590	dobj	positions,indicate
R19137	T24593	T24592	prep	of,positions
R19138	T24594	T24593	pobj	α,of
R19139	T24595	T24594	cc	and,α
R19140	T24596	T24594	conj	β,α
R19141	T24597	T24592	conj	isoforms,positions
R19142	T24598	T24592	prep	of,positions
R19143	T24599	T24598	pobj	GSK3,of
R19144	T24600	T24590	punct	.,indicate
R19145	T24601	T24603	det	The,line
R19146	T24602	T24603	amod	white,line
R19147	T24603	T24604	nsubj	line,indicates
R19148	T24604	T24604	ROOT	indicates,indicates
R19149	T24605	T24610	mark	that,spliced
R19150	T24606	T24607	amod	intervening,lanes
R19151	T24607	T24610	nsubjpass	lanes,spliced
R19152	T24608	T24610	aux	have,spliced
R19153	T24609	T24610	auxpass	been,spliced
R19154	T24610	T24604	ccomp	spliced,indicates
R19155	T24611	T24610	prt	out,spliced
R19156	T24612	T24604	punct	.,indicates
R19157	T24613	T24617	punct	(,analysis
R19158	T24614	T24617	nmod	C,analysis
R19159	T24615	T24614	punct	),C
R19160	T24616	T24617	compound	Immunoblot,analysis
R19161	T24617	T24617	ROOT	analysis,analysis
R19162	T24618	T24617	prep	for,analysis
R19163	T24619	T24620	compound	cell,cycle
R19164	T24620	T24621	compound	cycle,proteins
R19165	T24621	T24618	pobj	proteins,for
R19166	T24622	T24621	acl	regulating,proteins
R19167	T24623	T24625	det	the,pathway
R19168	T24624	T24625	compound	Rb,pathway
R19169	T24625	T24622	dobj	pathway,regulating
R19170	T24626	T24617	punct	",",analysis
R19171	T24627	T24617	acl	probing,analysis
R19172	T24628	T24627	prep	for,probing
R19173	T24629	T24630	amod	activated,pRb
R19174	T24630	T24628	pobj	pRb,for
R19175	T24631	T24630	punct	",",pRb
R19176	T24632	T24627	cc	and,probing
R19177	T24633	T24634	amod	total,levels
R19178	T24634	T24627	conj	levels,probing
R19179	T24635	T24634	prep	of,levels
R19180	T24636	T24635	pobj	Cdk2,of
R19181	T24637	T24636	cc	and,Cdk2
R19182	T24638	T24640	det	the,inhibitor
R19183	T24639	T24640	compound	Cdk,inhibitor
R19184	T24640	T24641	compound	inhibitor,p27
R19185	T24641	T24636	conj	p27,Cdk2
R19186	T24642	T24617	punct	.,analysis
R19187	T24643	T24645	nsubjpass	Actin,used
R19188	T24644	T24645	auxpass	was,used
R19189	T24645	T24645	ROOT	used,used
R19190	T24646	T24645	prep	as,used
R19191	T24647	T24649	det	a,control
R19192	T24648	T24649	compound	loading,control
R19193	T24649	T24646	pobj	control,as
R19194	T24650	T24645	punct	.,used
R19064	T24520	T24520	ROOT	LMP1,LMP1
R19065	T24521	T24522	compound	Activates,Akt
R19066	T24522	T24564	npadvmod	Akt,activated
R19067	T24523	T24525	amod	Signaling,Deregulates
R19068	T24524	T24523	cc	and,Signaling
R19069	T24525	T24564	dep	Deregulates,activated
R19070	T24526	T24530	det	the,Pathway
R19071	T24527	T24530	compound	Rb,Pathway
R19072	T24528	T24529	compound	Cell,Cycle
R19073	T24529	T24530	compound	Cycle,Pathway
R19074	T24530	T24525	dobj	Pathway,Deregulates
R19075	T24531	T24532	punct	(,A
R19076	T24532	T24525	appos	A,Deregulates
R19077	T24533	T24532	cc	and,A
R19078	T24534	T24537	nmod	B,analysis
R8182	T10702	T10701	dobj	Akt,activated
R8118	T10638	T10639	amod	transgenic,lymphocytes
R8119	T10639	T10636	pobj	lymphocytes,in
R8120	T10640	T10635	cc	and,detected
R8121	T10641	T10643	auxpass	was,absent
R8122	T10642	T10643	advmod	almost,absent
R8123	T10643	T10635	conj	absent,detected
R8124	T10644	T10643	prep	in,absent
R8125	T10645	T10647	det	the,samples
R8126	T10646	T10647	compound	lymphoma,samples
R8127	T10647	T10644	pobj	samples,in
R8128	T10648	T10650	punct	(,6A
R8129	T10649	T10650	compound	Figure,6A
R8130	T10650	T10647	appos	6A,samples
R8131	T10651	T10643	punct	),absent
R8132	T10652	T10630	punct	.,increased
R8351	T10871	T10870	dobj	pathway,signaling
R8352	T10872	T10864	ccomp	is,suggesting
R8353	T10873	T10875	det	an,target
R8354	T10874	T10875	amod	important,target
R8355	T10875	T10872	attr	target,is
R8356	T10876	T10875	prep	of,target
R8357	T10877	T10876	pobj	Akt,of
R8358	T10878	T10875	prep	in,target
R8359	T10879	T10880	compound	lymphoma,development
R8360	T10880	T10878	pobj	development,in
R8361	T10881	T10845	punct	.,indicated
R8362	T10882	T10902	advmod	However,be
R8363	T10883	T10902	punct	",",be
R8364	T10884	T10902	advcl	considering,be
R8365	T10885	T10887	det	that,activation
R8366	T10886	T10887	compound	Akt,activation
R8367	T10887	T10890	nsubj	activation,induce
R8368	T10888	T10890	aux	did,induce
R8369	T10889	T10890	neg	not,induce
R8370	T10890	T10884	ccomp	induce,considering
R8371	T10891	T10892	amod	FoxO1,degradation
R8372	T10892	T10890	dobj	degradation,induce
R8373	T10893	T10892	prep	in,degradation
R8374	T10894	T10897	nummod	LMP1,cells
R8375	T10895	T10897	amod	transgenic,cells
R8376	T10896	T10897	compound	B,cells
R8377	T10897	T10893	pobj	cells,in
R8378	T10898	T10902	punct	",",be
R8379	T10899	T10902	nsubj	Akt,be
R8380	T10900	T10902	aux	may,be
R8381	T10901	T10902	neg	not,be
R8382	T10902	T10902	ROOT	be,be
R8383	T10903	T10905	det	the,regulator
R8384	T10904	T10905	amod	sole,regulator
R8385	T10905	T10902	attr	regulator,be
R8386	T10906	T10905	prep	of,regulator
R8387	T10907	T10906	pobj	FoxO1,of
R8388	T10908	T10902	punct	",",be
R8389	T10909	T10902	cc	and,be
R8390	T10910	T10912	nsubj	it,be
R8391	T10911	T10912	aux	may,be
R8430	T10950	T10949	prep	of,expression
R8431	T10951	T10950	pobj	p27,of
R8432	T10952	T10948	punct	",",decreased
R8433	T10953	T10948	npadvmod	upregulation,decreased
R8434	T10954	T10953	prep	of,upregulation
R8435	T10955	T10954	pobj	Cdk2,of
R8436	T10956	T10953	punct	",",upregulation
R8437	T10957	T10953	cc	and,upregulation
R8438	T10958	T10959	amod	subsequent,phosphorylation
R8439	T10959	T10953	conj	phosphorylation,upregulation
R8440	T10960	T10959	cc	and,phosphorylation
R8441	T10961	T10959	conj	inactivation,phosphorylation
R8442	T10962	T10959	prep	of,phosphorylation
R8443	T10963	T10966	det	the,gene
R8444	T10964	T10966	compound	tumor,gene
R8445	T10965	T10966	compound	suppressor,gene
R8446	T10966	T10970	nmod	gene,]
R8447	T10967	T10968	compound	Rb,[
R8448	T10968	T10966	appos	[,gene
R8449	T10969	T10970	nummod	45,]
R8450	T10970	T10962	pobj	],of

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T24343	1462-1469	http://purl.obolibrary.org/obo/UBERON_0002106	denotes	spleens

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T9792	52-62	http://purl.obolibrary.org/obo/GO_0007049	denotes	Cell Cycle
T9793	2428-2438	http://purl.obolibrary.org/obo/GO_0007049	denotes	cell cycle
T9794	3507-3517	http://purl.obolibrary.org/obo/GO_0007049	denotes	cell cycle
T9795	136-140	http://purl.obolibrary.org/obo/GO_0016303	denotes	PI3K
T9796	298-307	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T9797	2875-2884	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T9798	727-742	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T9799	1047-1062	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T9800	3399-3414	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T9801	1294-1304	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T9802	3518-3528	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T9803	2267-2278	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T9804	2935-2946	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T9805	2342-2353	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T9806	2609-2620	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T9807	2629-2640	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T9808	3010-3021	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T9809	2394-2407	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T9810	3202-3215	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T9811	2428-2450	http://purl.obolibrary.org/obo/GO_0007050	denotes	cell cycle progression
T9812	2428-2450	http://purl.obolibrary.org/obo/GO_0051726	denotes	cell cycle progression
T9813	3439-3455	http://purl.obolibrary.org/obo/GO_0051726	denotes	tumor suppressor
T9814	3507-3536	http://purl.obolibrary.org/obo/GO_0051726	denotes	cell cycle regulation through
T9815	2875-2892	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathway
T9816	3507-3528	http://purl.obolibrary.org/obo/GO_0051445	denotes	cell cycle regulation
T9817	3507-3528	http://purl.obolibrary.org/obo/GO_1901976	denotes	cell cycle regulation
T9818	3507-3528	http://purl.obolibrary.org/obo/GO_0010564	denotes	cell cycle regulation
T9819	3507-3528	http://purl.obolibrary.org/obo/GO_0032465	denotes	cell cycle regulation
T9820	3507-3528	http://purl.obolibrary.org/obo/GO_0045787	denotes	cell cycle regulation
T9821	3507-3528	http://purl.obolibrary.org/obo/GO_0007346	denotes	cell cycle regulation
T9822	3507-3528	http://purl.obolibrary.org/obo/GO_0045786	denotes	cell cycle regulation
T9823	3507-3528	http://purl.obolibrary.org/obo/GO_0071156	denotes	cell cycle regulation
T24372	1376-1386	http://purl.obolibrary.org/obo/GO_0007049	denotes	Cell Cycle
T24373	1818-1828	http://purl.obolibrary.org/obo/GO_0007049	denotes	cell cycle
T24374	1509-1518	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T24375	1777-1784	http://purl.obolibrary.org/obo/GO_0045292	denotes	spliced

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T11119	136-140	http://purl.obolibrary.org/obo/GO_0016303	denotes	PI3K

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T11122	443-448	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11123	468-473	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11124	616-621	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11125	1003-1008	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11126	2148-2153	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11127	2527-2532	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11128	3043-3048	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11129	3557-3562	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11130	3655-3660	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11131	3680-3685	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11132	3892-3897	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11133	4111-4116	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11134	209-212	http://purl.obolibrary.org/obo/GO_0005643	denotes	NPC
T11120	52-56	http://purl.obolibrary.org/obo/GO_0005623	denotes	Cell
T11121	247-252	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T24657	1376-1380	http://purl.obolibrary.org/obo/GO_0005623	denotes	Cell
T24658	1439-1444	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T24659	1818-1822	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell

sentences

Id	Subject	Object	Predicate	Lexical cue
T9769	0-70	Sentence	denotes	LMP1 Activates Akt Signaling and Deregulates the Rb Cell Cycle Pathway
T9770	71-153	Sentence	denotes	LMP1 transformation of rodent fibroblasts requires activation of PI3K and Akt [5].
T9771	154-277	Sentence	denotes	Additionally, activated pAkt is frequently detected in NPC and the neoplastic Reed-Sternberg cells of classical HD [39,40].
T9772	278-449	Sentence	denotes	To determine if Akt signaling is activated in LMP1 transgenic mice, pAkt and several of its targets were assessed by immunoblotting of splenic CD19+ MACS-purified B cells.
T9773	450-659	Sentence	denotes	LMP1 transgenic B cells had increased levels of pAkt compared to wild-type lymphocytes; however, progression to lymphoma in both LMP1-positive and -negative lymphoma cells did not further increase pAkt levels.
T9774	660-888	Sentence	denotes	The Akt target glycogen synthase kinase 3 (GSK3) is inactivated by phosphorylation; however, increased phosphorylated GSK3 was not detected in the transgenic lymphocytes and was almost absent in the lymphoma samples (Figure 6A).
T9775	889-1009	Sentence	denotes	This finding indicates that GSK3 is not a target of activated Akt in the LMP1 transgenic lymphocytes and lymphoma cells.
T9776	1010-1121	Sentence	denotes	Similarly, activation of Akt without phosphorylation of GSK3 has been previously shown in EBV-positive HD [40].
T9777	1122-1226	Sentence	denotes	In contrast, the wild-type lymphocytes lacked activated Akt but did have detectable phosphorylated GSK3.
T9778	1227-1313	Sentence	denotes	This further suggests that additional pathways are involved in the regulation of GSK3.
T9779	1983-2069	Sentence	denotes	To identify other potential Akt targets, immunoblot analysis for p-mTOR was performed.
T9780	2070-2291	Sentence	denotes	Activated p-mTOR was not increased in LMP1 transgenic lymphocytes or lymphoma cells, indicating that this pathway is not affected by LMP1-induced Akt activation and does not contribute to lymphoma development (Figure 6B).
T9781	2292-2493	Sentence	denotes	Akt is also known to phosphorylate and induce the degradation of the pro-apoptotic Forkhead family of transcription factors, leading to cell cycle progression and survival in some human tumors [41,42].
T9782	2494-2621	Sentence	denotes	Immunoblot analysis of splenic B cells did not consistently detect p-FoxO1 levels, a signal that targets FoxO1 for degradation.
T9783	2622-2698	Sentence	denotes	Hence, degradation of FoxO1 was assessed by detection of total FoxO1 levels.
T9784	2699-2947	Sentence	denotes	Immunoblot analysis indicated that total FoxO1 levels were greatly decreased in wild-type and LMP1 transgenic lymphomas (Figure 6B), suggesting that inhibition of the Forkhead signaling pathway is an important target of Akt in lymphoma development.
T9785	2948-3178	Sentence	denotes	However, considering that Akt activation did not induce FoxO1 degradation in LMP1 transgenic B cells, Akt may not be the sole regulator of FoxO1, and it may be that progression to lymphoma requires modulation of multiple pathways.
T9786	3179-3291	Sentence	denotes	The Forkhead family of transcription factors is known to induce the expression of the Cdk inhibitor p27 [43,44].
T9787	3292-3469	Sentence	denotes	LMP1-transformed rodent fibroblasts have decreased expression of p27, upregulation of Cdk2, and subsequent phosphorylation and inactivation of the tumor suppressor gene Rb [45].
T9788	3470-3661	Sentence	denotes	To investigate whether LMP1 affected cell cycle regulation through the Rb pathway in B cells, immunoblot analyses for pRb, Cdk2, and p27 were performed on splenic CD19+ MACS-purified B cells.
T9789	3662-3820	Sentence	denotes	LMP1 transgenic B cells had enhanced levels of pRb with concomitant stabilization of total Rb levels and Cdk2 compared to wild-type B lymphocytes (Figure 6C).
T9790	3821-4006	Sentence	denotes	Progression to lymphoma in both wild-type and LMP1 transgenic lymphoma cells led to increased levels of Rb, correspondingly high levels of Cdk2, and decreased levels of p27 (Figure 6C).
T9791	4007-4170	Sentence	denotes	These data indicate that the Rb pathway is deregulated in LMP1 transgenic lymphocytes and that lymphoma cells are distinguished by loss of FoxO1 and decreased p27.
T24366	1324-1394	Sentence	denotes	LMP1 Activates Akt Signaling and Deregulates the Rb Cell Cycle Pathway
T24367	1395-1659	Sentence	denotes	(A and B) Immunoblot analysis of purified B cells (CD19+) from the spleens of WT and LMP1 transgenic mice for Akt signaling, probing for (A) activated pAkt and downstream targets, including inactivated pGSK3α/β, and (B) activated p-mTOR, and total levels of FoxO1.
T24368	1660-1718	Sentence	denotes	Arrows indicate the positions of α and β isoforms of GSK3.
T24369	1719-1789	Sentence	denotes	The white line indicates that intervening lanes have been spliced out.
T24370	1790-1943	Sentence	denotes	(C) Immunoblot analysis for cell cycle proteins regulating the Rb pathway, probing for activated pRb, and total levels of Cdk2 and the Cdk inhibitor p27.
T24371	1944-1980	Sentence	denotes	Actin was used as a loading control.
T170	0-70	Sentence	denotes	LMP1 Activates Akt Signaling and Deregulates the Rb Cell Cycle Pathway
T171	71-153	Sentence	denotes	LMP1 transformation of rodent fibroblasts requires activation of PI3K and Akt [5].
T172	154-277	Sentence	denotes	Additionally, activated pAkt is frequently detected in NPC and the neoplastic Reed-Sternberg cells of classical HD [39,40].
T173	278-449	Sentence	denotes	To determine if Akt signaling is activated in LMP1 transgenic mice, pAkt and several of its targets were assessed by immunoblotting of splenic CD19+ MACS-purified B cells.
T174	450-659	Sentence	denotes	LMP1 transgenic B cells had increased levels of pAkt compared to wild-type lymphocytes; however, progression to lymphoma in both LMP1-positive and -negative lymphoma cells did not further increase pAkt levels.
T175	660-888	Sentence	denotes	The Akt target glycogen synthase kinase 3 (GSK3) is inactivated by phosphorylation; however, increased phosphorylated GSK3 was not detected in the transgenic lymphocytes and was almost absent in the lymphoma samples (Figure 6A).
T176	889-1009	Sentence	denotes	This finding indicates that GSK3 is not a target of activated Akt in the LMP1 transgenic lymphocytes and lymphoma cells.
T177	1010-1121	Sentence	denotes	Similarly, activation of Akt without phosphorylation of GSK3 has been previously shown in EBV-positive HD [40].
T178	1122-1226	Sentence	denotes	In contrast, the wild-type lymphocytes lacked activated Akt but did have detectable phosphorylated GSK3.
T179	1227-1313	Sentence	denotes	This further suggests that additional pathways are involved in the regulation of GSK3.
T180	1314-1394	Sentence	denotes	Figure 6 LMP1 Activates Akt Signaling and Deregulates the Rb Cell Cycle Pathway
T181	1395-1659	Sentence	denotes	(A and B) Immunoblot analysis of purified B cells (CD19+) from the spleens of WT and LMP1 transgenic mice for Akt signaling, probing for (A) activated pAkt and downstream targets, including inactivated pGSK3α/β, and (B) activated p-mTOR, and total levels of FoxO1.
T182	1660-1718	Sentence	denotes	Arrows indicate the positions of α and β isoforms of GSK3.
T183	1719-1789	Sentence	denotes	The white line indicates that intervening lanes have been spliced out.
T184	1790-1943	Sentence	denotes	(C) Immunoblot analysis for cell cycle proteins regulating the Rb pathway, probing for activated pRb, and total levels of Cdk2 and the Cdk inhibitor p27.
T185	1944-1980	Sentence	denotes	Actin was used as a loading control.
T186	1983-2069	Sentence	denotes	To identify other potential Akt targets, immunoblot analysis for p-mTOR was performed.
T187	2070-2291	Sentence	denotes	Activated p-mTOR was not increased in LMP1 transgenic lymphocytes or lymphoma cells, indicating that this pathway is not affected by LMP1-induced Akt activation and does not contribute to lymphoma development (Figure 6B).
T188	2292-2493	Sentence	denotes	Akt is also known to phosphorylate and induce the degradation of the pro-apoptotic Forkhead family of transcription factors, leading to cell cycle progression and survival in some human tumors [41,42].
T189	2494-2621	Sentence	denotes	Immunoblot analysis of splenic B cells did not consistently detect p-FoxO1 levels, a signal that targets FoxO1 for degradation.
T190	2622-2698	Sentence	denotes	Hence, degradation of FoxO1 was assessed by detection of total FoxO1 levels.
T191	2699-2947	Sentence	denotes	Immunoblot analysis indicated that total FoxO1 levels were greatly decreased in wild-type and LMP1 transgenic lymphomas (Figure 6B), suggesting that inhibition of the Forkhead signaling pathway is an important target of Akt in lymphoma development.
T192	2948-3178	Sentence	denotes	However, considering that Akt activation did not induce FoxO1 degradation in LMP1 transgenic B cells, Akt may not be the sole regulator of FoxO1, and it may be that progression to lymphoma requires modulation of multiple pathways.
T193	3179-3291	Sentence	denotes	The Forkhead family of transcription factors is known to induce the expression of the Cdk inhibitor p27 [43,44].
T194	3292-3469	Sentence	denotes	LMP1-transformed rodent fibroblasts have decreased expression of p27, upregulation of Cdk2, and subsequent phosphorylation and inactivation of the tumor suppressor gene Rb [45].
T195	3470-3661	Sentence	denotes	To investigate whether LMP1 affected cell cycle regulation through the Rb pathway in B cells, immunoblot analyses for pRb, Cdk2, and p27 were performed on splenic CD19+ MACS-purified B cells.
T196	3662-3820	Sentence	denotes	LMP1 transgenic B cells had enhanced levels of pRb with concomitant stabilization of total Rb levels and Cdk2 compared to wild-type B lymphocytes (Figure 6C).
T197	3821-4006	Sentence	denotes	Progression to lymphoma in both wild-type and LMP1 transgenic lymphoma cells led to increased levels of Rb, correspondingly high levels of Cdk2, and decreased levels of p27 (Figure 6C).
T198	4007-4170	Sentence	denotes	These data indicate that the Rb pathway is deregulated in LMP1 transgenic lymphocytes and that lymphoma cells are distinguished by loss of FoxO1 and decreased p27.

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T11445	0-4	Protein	denotes	LMP1
T11446	15-18	Protein	denotes	Akt
T11447	49-51	Protein	denotes	Rb
T11448	71-75	Protein	denotes	LMP1
T11449	113-121	Positive_regulation	denotes	requires
T11450	122-132	Positive_regulation	denotes	activation
T11451	145-148	Protein	denotes	Akt
T11452	168-177	Positive_regulation	denotes	activated
T11453	178-182	Protein	denotes	pAkt
T11454	294-297	Protein	denotes	Akt
T11455	324-328	Protein	denotes	LMP1
T11456	346-350	Protein	denotes	pAkt
T11457	421-425	Protein	denotes	CD19
T11458	450-454	Protein	denotes	LMP1
T11459	478-487	Positive_regulation	denotes	increased
T11460	498-502	Protein	denotes	pAkt
T11461	579-583	Protein	denotes	LMP1
T11462	638-646	Positive_regulation	denotes	increase	true
T11463	647-651	Protein	denotes	pAkt
T11464	664-667	Protein	denotes	Akt
T11465	668-674	Binding	denotes	target
T11466	675-701	Protein	denotes	glycogen synthase kinase 3
T11467	703-707	Protein	denotes	GSK3
T11468	712-723	Negative_regulation	denotes	inactivated
T11469	753-762	Positive_regulation	denotes	increased	true
T11470	763-777	Phosphorylation	denotes	phosphorylated
T11471	778-782	Protein	denotes	GSK3
T11472	917-921	Protein	denotes	GSK3
T11473	931-937	Binding	denotes	target	true
T11474	941-950	Positive_regulation	denotes	activated
T11475	951-954	Protein	denotes	Akt
T11476	962-966	Protein	denotes	LMP1
T11477	1021-1031	Positive_regulation	denotes	activation
T11478	1035-1038	Protein	denotes	Akt
T11479	1047-1062	Phosphorylation	denotes	phosphorylation
T11480	1066-1070	Protein	denotes	GSK3
T11481	1168-1177	Positive_regulation	denotes	activated	true
T11482	1178-1181	Protein	denotes	Akt
T11483	1206-1220	Phosphorylation	denotes	phosphorylated
T11484	1221-1225	Protein	denotes	GSK3
T11485	1294-1304	Regulation	denotes	regulation
T11486	1308-1312	Protein	denotes	GSK3
T11487	2011-2014	Protein	denotes	Akt
T11488	2015-2022	Binding	denotes	targets		true
T11489	2048-2054	Protein	denotes	p-mTOR
T11490	2070-2079	Positive_regulation	denotes	Activated
T11491	2080-2086	Protein	denotes	p-mTOR
T11492	2095-2104	Positive_regulation	denotes	increased	true
T11493	2108-2112	Protein	denotes	LMP1
T11494	2191-2199	Regulation	denotes	affected	true
T11495	2203-2207	Protein	denotes	LMP1
T11496	2208-2215	Positive_regulation	denotes	induced
T11497	2216-2219	Protein	denotes	Akt
T11498	2220-2230	Positive_regulation	denotes	activation
T11499	2292-2295	Protein	denotes	Akt
T11500	2563-2568	Protein	denotes	FoxO1
T11501	2591-2598	Regulation	denotes	targets
T11502	2599-2604	Protein	denotes	FoxO1
T11503	2644-2649	Protein	denotes	FoxO1
T11504	2685-2690	Protein	denotes	FoxO1
T11505	2740-2745	Protein	denotes	FoxO1
T11506	2766-2775	Negative_regulation	denotes	decreased
T11507	2793-2797	Protein	denotes	LMP1
T11508	2919-2922	Protein	denotes	Akt
T11509	2974-2977	Protein	denotes	Akt
T11510	2978-2988	Positive_regulation	denotes	activation
T11511	2997-3003	Positive_regulation	denotes	induce	true
T11512	3004-3009	Protein	denotes	FoxO1
T11513	3010-3021	Negative_regulation	denotes	degradation
T11514	3025-3029	Protein	denotes	LMP1
T11515	3050-3053	Protein	denotes	Akt
T11516	3074-3083	Regulation	denotes	regulator	true	true
T11517	3087-3092	Protein	denotes	FoxO1
T11518	3247-3257	Gene_expression	denotes	expression
T11519	3279-3282	Protein	denotes	p27
T11520	3292-3296	Protein	denotes	LMP1
T11521	3357-3360	Protein	denotes	p27
T11522	3378-3382	Protein	denotes	Cdk2
T11523	3461-3463	Protein	denotes	Rb
T11524	3493-3497	Protein	denotes	LMP1
T11525	3541-3543	Protein	denotes	Rb
T11526	3588-3591	Protein	denotes	pRb
T11527	3593-3597	Protein	denotes	Cdk2
T11528	3603-3606	Protein	denotes	p27
T11529	3633-3637	Protein	denotes	CD19
T11530	3662-3666	Protein	denotes	LMP1
T11531	3690-3698	Positive_regulation	denotes	enhanced
T11532	3690-3698	Positive_regulation	denotes	enhanced
T11533	3709-3712	Protein	denotes	pRb
T11534	3753-3755	Protein	denotes	Rb
T11535	3767-3771	Protein	denotes	Cdk2
T11536	3867-3871	Protein	denotes	LMP1
T11537	3898-3901	Positive_regulation	denotes	led
T11538	3905-3914	Positive_regulation	denotes	increased
T11539	3925-3927	Protein	denotes	Rb
T11540	3945-3956	Positive_regulation	denotes	high levels
T11541	3960-3964	Protein	denotes	Cdk2
T11542	3970-3979	Negative_regulation	denotes	decreased
T11543	3990-3993	Protein	denotes	p27
T11544	4036-4038	Protein	denotes	Rb
T11545	4065-4069	Protein	denotes	LMP1
T11546	4138-4142	Negative_regulation	denotes	loss
T11547	4146-4151	Protein	denotes	FoxO1
T11548	4156-4165	Negative_regulation	denotes	decreased
T11549	4166-4169	Protein	denotes	p27
T24726	1324-1328	Protein	denotes	LMP1
T24727	1339-1342	Protein	denotes	Akt
T24728	1373-1375	Protein	denotes	Rb
T24729	1446-1450	Protein	denotes	CD19
T24730	1480-1484	Protein	denotes	LMP1
T24731	1505-1508	Protein	denotes	Akt
T24732	1546-1550	Protein	denotes	pAkt
T24733	1566-1573	Regulation	denotes	targets
T24734	1566-1573	Regulation	denotes	targets
T24735	1585-1596	Positive_regulation	denotes	inactivated	true	true
T24736	1585-1596	Positive_regulation	denotes	inactivated	true	true
T24737	1597-1603	Protein	denotes	pGSK3α
T24738	1604-1605	Protein	denotes	β
T24739	1615-1624	Positive_regulation	denotes	activated		true
T24740	1625-1631	Protein	denotes	p-mTOR
T24741	1653-1658	Protein	denotes	FoxO1
T24742	1713-1717	Protein	denotes	GSK3
T24743	1853-1855	Protein	denotes	Rb
T24744	1877-1886	Positive_regulation	denotes	activated		true
T24745	1887-1890	Protein	denotes	pRb
T24746	1912-1916	Protein	denotes	Cdk2
T24747	1939-1942	Protein	denotes	p27
R8705	T11450	T11449	themeOf	activation,requires
R8706	T11451	T11450	themeOf	Akt,activation
R8707	T11453	T11452	themeOf	pAkt,activated
R8708	T11460	T11459	themeOf	pAkt,increased
R8709	T11463	T11462	themeOf	pAkt,increase
R8710	T11464	T11465	themeOf	Akt,target
R8711	T11465	T11468	themeOf	target,inactivated
R8712	T11466	T11465	themeOf	glycogen synthase kinase 3,target
R8713	T11467	T11466	equivalentTo	GSK3,glycogen synthase kinase 3
R8714	T11470	T11469	themeOf	phosphorylated,increased
R8715	T11471	T11470	themeOf	GSK3,phosphorylated
R8716	T11472	T11473	themeOf	GSK3,target
R8717	T11475	T11473	themeOf	Akt,target
R8718	T11475	T11474	themeOf	Akt,activated
R8719	T11478	T11477	themeOf	Akt,activation
R8720	T11480	T11479	themeOf	GSK3,phosphorylation
R8721	T11482	T11481	themeOf	Akt,activated
R8722	T11484	T11483	themeOf	GSK3,phosphorylated
R8723	T11486	T11485	themeOf	GSK3,regulation
R8724	T11487	T11488	themeOf	Akt,targets
R8725	T11490	T11492	themeOf	Activated,increased
R8726	T11490	T11494	themeOf	Activated,affected
R8727	T11491	T11490	themeOf	p-mTOR,Activated
R8728	T11495	T11496	causeOf	LMP1,induced
R8729	T11496	T11494	causeOf	induced,affected
R8730	T11497	T11498	themeOf	Akt,activation
R8731	T11498	T11496	themeOf	activation,induced
R8732	T11502	T11501	themeOf	FoxO1,targets
R8733	T11505	T11506	themeOf	FoxO1,decreased
R8734	T11509	T11510	themeOf	Akt,activation
R8735	T11510	T11511	causeOf	activation,induce
R8736	T11512	T11513	themeOf	FoxO1,degradation
R8737	T11513	T11511	themeOf	degradation,induce
R8738	T11515	T11516	causeOf	Akt,regulator
R8739	T11517	T11516	themeOf	FoxO1,regulator
R8740	T11519	T11518	themeOf	p27,expression
R8741	T11533	T11531	themeOf	pRb,enhanced
R8742	T11535	T11532	themeOf	Cdk2,enhanced
R8743	T11538	T11537	themeOf	increased,led
R8744	T11539	T11538	themeOf	Rb,increased
R8745	T11541	T11540	themeOf	Cdk2,high levels
R8746	T11543	T11542	themeOf	p27,decreased
R8747	T11547	T11546	themeOf	FoxO1,loss
R8748	T11549	T11548	themeOf	p27,decreased
R19213	T24737	T24733	themeOf	pGSK3α,targets
R19214	T24737	T24736	themeOf	pGSK3α,inactivated
R19215	T24738	T24734	themeOf	β,targets
R19216	T24738	T24735	themeOf	β,inactivated
R19217	T24740	T24739	themeOf	p-mTOR,activated
R19218	T24745	T24744	themeOf	pRb,activated

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T11345	0-4	Protein	denotes	LMP1
T11346	15-18	Protein	denotes	Akt
T11347	49-62	Protein	denotes	Rb Cell Cycle
T11348	5-14	Positive_regulation	denotes	Activates
T11349	71-75	Protein	denotes	LMP1
T11350	136-140	Protein	denotes	PI3K
T11351	145-152	Protein	denotes	Akt [5]
T11352	122-132	Positive_regulation	denotes	activation
T11353	113-121	Positive_regulation	denotes	requires
T11354	178-182	Protein	denotes	pAkt
T11355	168-177	Positive_regulation	denotes	activated
T11356	294-297	Protein	denotes	Akt
T11357	324-328	Protein	denotes	LMP1
T11358	413-431	Protein	denotes	splenic CD19+ MACS
T11359	450-454	Protein	denotes	LMP1
T11360	579-583	Protein	denotes	LMP1
T11361	647-651	Protein	denotes	pAkt
T11362	638-646	Positive_regulation	denotes	increase
T11363	664-701	Protein	denotes	Akt target glycogen synthase kinase 3
T11364	703-707	Protein	denotes	GSK3
T11365	778-782	Protein	denotes	GSK3
T11366	712-723	Negative_regulation	denotes	inactivated
T11367	712-723	Negative_regulation	denotes	inactivated
T11368	763-777	Phosphorylation	denotes	phosphorylated
T11369	753-762	Positive_regulation	denotes	increased
T11370	917-921	Protein	denotes	GSK3
T11371	951-954	Protein	denotes	Akt
T11372	962-966	Protein	denotes	LMP1
T11373	931-937	Binding	denotes	target
T11374	941-950	Positive_regulation	denotes	activated
T11375	1035-1038	Protein	denotes	Akt
T11376	1066-1070	Protein	denotes	GSK3
T11377	1021-1031	Positive_regulation	denotes	activation
T11378	1047-1062	Phosphorylation	denotes	phosphorylation
T11379	1021-1031	Positive_regulation	denotes	activation
T11380	1178-1181	Protein	denotes	Akt
T11381	1221-1225	Protein	denotes	GSK3
T11382	1168-1177	Positive_regulation	denotes	activated
T11383	1206-1220	Phosphorylation	denotes	phosphorylated
T11384	1308-1312	Protein	denotes	GSK3
T11385	1294-1304	Regulation	denotes	regulation
T11386	2070-2086	Protein	denotes	Activated p-mTOR
T11387	2108-2112	Protein	denotes	LMP1
T11388	2203-2207	Protein	denotes	LMP1
T11389	2216-2219	Protein	denotes	Akt
T11390	2095-2104	Positive_regulation	denotes	increased
T11391	2292-2295	Protein	denotes	Akt
T11392	2599-2604	Protein	denotes	FoxO1
T11393	2609-2620	Protein_catabolism	denotes	degradation
T11394	2591-2598	Regulation	denotes	targets
T11395	2644-2649	Protein	denotes	FoxO1
T11396	2685-2690	Protein	denotes	FoxO1
T11397	2629-2640	Protein_catabolism	denotes	degradation
T11398	2740-2745	Protein	denotes	FoxO1
T11399	2793-2797	Protein	denotes	LMP1
T11400	2866-2874	Protein	denotes	Forkhead
T11401	2919-2922	Protein	denotes	Akt
T11402	2766-2775	Negative_regulation	denotes	decreased
T11403	2848-2858	Negative_regulation	denotes	inhibition
T11404	2909-2915	Positive_regulation	denotes	target
T11405	2974-2977	Protein	denotes	Akt
T11406	3004-3009	Protein	denotes	FoxO1
T11407	3025-3029	Protein	denotes	LMP1
T11408	3050-3053	Protein	denotes	Akt
T11409	3087-3092	Protein	denotes	FoxO1
T11410	2978-2988	Positive_regulation	denotes	activation
T11411	3010-3021	Negative_regulation	denotes	degradation
T11412	3074-3083	Regulation	denotes	regulator
T11413	3183-3223	Protein	denotes	Forkhead family of transcription factors
T11414	3265-3268	Protein	denotes	Cdk
T11415	3247-3257	Gene_expression	denotes	expression
T11416	3292-3296	Protein	denotes	LMP1
T11417	3357-3360	Protein	denotes	p27
T11418	3378-3382	Protein	denotes	Cdk2
T11419	3343-3353	Gene_expression	denotes	expression
T11420	3362-3374	Positive_regulation	denotes	upregulation
T11421	3493-3497	Protein	denotes	LMP1
T11422	3541-3543	Protein	denotes	Rb
T11423	3588-3591	Protein	denotes	pRb
T11424	3593-3597	Protein	denotes	Cdk2
T11425	3603-3606	Protein	denotes	p27
T11426	3625-3643	Protein	denotes	splenic CD19+ MACS
T11427	3662-3666	Protein	denotes	LMP1
T11428	3709-3712	Protein	denotes	pRb
T11429	3753-3755	Protein	denotes	Rb
T11430	3767-3771	Protein	denotes	Cdk2
T11431	3690-3698	Positive_regulation	denotes	enhanced
T11432	3690-3698	Positive_regulation	denotes	enhanced
T11433	3867-3871	Protein	denotes	LMP1
T11434	3925-3927	Protein	denotes	Rb
T11435	3960-3964	Protein	denotes	Cdk2
T11436	3990-3993	Protein	denotes	p27
T11437	3905-3914	Positive_regulation	denotes	increased
T11438	3970-3979	Negative_regulation	denotes	decreased
T11439	4036-4038	Protein	denotes	Rb
T11440	4065-4069	Protein	denotes	LMP1
T11441	4166-4169	Protein	denotes	p27
T11442	4138-4142	Negative_regulation	denotes	loss
T11443	4156-4165	Negative_regulation	denotes	decreased
T11444	4138-4142	Negative_regulation	denotes	loss
T24706	1373-1386	Protein	denotes	Rb Cell Cycle
T24707	1329-1338	Positive_regulation	denotes	Activates
T24708	1446-1450	Protein	denotes	CD19
T24709	1473-1475	Protein	denotes	WT
T24710	1480-1484	Protein	denotes	LMP1
T24711	1505-1508	Protein	denotes	Akt
T24712	1546-1550	Protein	denotes	pAkt
T24713	1597-1605	Protein	denotes	pGSK3α/β
T24714	1653-1658	Protein	denotes	FoxO1
T24715	1536-1545	Positive_regulation	denotes	activated
T24716	1585-1596	Positive_regulation	denotes	inactivated
T24717	1713-1717	Protein	denotes	GSK3
T24718	1853-1855	Protein	denotes	Rb
T24719	1887-1890	Protein	denotes	pRb
T24720	1912-1916	Protein	denotes	Cdk2
T24721	1925-1928	Protein	denotes	Cdk
T24722	1939-1942	Protein	denotes	p27
T24723	1838-1848	Regulation	denotes	regulating
T24724	1877-1886	Positive_regulation	denotes	activated
T24725	1944-1949	Protein	denotes	Actin
T24704	1324-1328	Protein	denotes	LMP1
T24705	1339-1342	Protein	denotes	Akt
R8664	T11345	T11348	causeOf	LMP1,Activates
R8665	T11346	T11348	themeOf	Akt,Activates
R8666	T11350	T11352	themeOf	PI3K,activation
R8667	T11351	T11353	causeOf	Akt [5],requires
R8668	T11352	T11353	themeOf	activation,requires
R8669	T11354	T11355	themeOf	pAkt,activated
R8670	T11361	T11362	themeOf	pAkt,increase
R8671	T11363	T11366	themeOf	Akt target glycogen synthase kinase 3,inactivated
R8672	T11364	T11367	themeOf	GSK3,inactivated
R8673	T11365	T11368	themeOf	GSK3,phosphorylated
R8674	T11368	T11369	themeOf	phosphorylated,increased
R8675	T11370	T11373	themeOf	GSK3,target
R8676	T11371	T11373	themeOf	Akt,target
R8677	T11371	T11374	themeOf	Akt,activated
R8678	T11375	T11377	themeOf	Akt,activation
R8679	T11376	T11378	themeOf	GSK3,phosphorylation
R8680	T11378	T11379	themeOf	phosphorylation,activation
R8681	T11380	T11382	themeOf	Akt,activated
R8682	T11381	T11383	themeOf	GSK3,phosphorylated
R8683	T11384	T11385	themeOf	GSK3,regulation
R8684	T11386	T11390	themeOf	Activated p-mTOR,increased
R8685	T11392	T11393	themeOf	FoxO1,degradation
R8686	T11393	T11394	themeOf	degradation,targets
R8687	T11395	T11397	themeOf	FoxO1,degradation
R8688	T11398	T11402	themeOf	FoxO1,decreased
R8689	T11400	T11403	themeOf	Forkhead,inhibition
R8690	T11401	T11404	themeOf	Akt,target
R8691	T11405	T11410	themeOf	Akt,activation
R8692	T11406	T11411	themeOf	FoxO1,degradation
R8693	T11408	T11412	causeOf	Akt,regulator
R8694	T11409	T11412	themeOf	FoxO1,regulator
R8695	T11414	T11415	themeOf	Cdk,expression
R8696	T11417	T11419	themeOf	p27,expression
R8697	T11418	T11420	themeOf	Cdk2,upregulation
R8698	T11428	T11431	themeOf	pRb,enhanced
R8699	T11430	T11432	themeOf	Cdk2,enhanced
R8700	T11434	T11437	themeOf	Rb,increased
R8701	T11436	T11438	themeOf	p27,decreased
R8702	T11441	T11442	themeOf	p27,loss
R8703	T11441	T11443	themeOf	p27,decreased
R8704	T11443	T11444	themeOf	decreased,loss
R19207	T24704	T24707	causeOf	LMP1,Activates
R19208	T24705	T24707	themeOf	Akt,Activates
R19209	T24712	T24715	themeOf	pAkt,activated
R19210	T24713	T24716	themeOf	pGSK3α/β,inactivated
R19211	T24719	T24724	themeOf	pRb,activated
R19212	T24720	T24723	themeOf	Cdk2,regulating

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T9680	579-583	Protein	denotes	LMP1
T9681	638-646	Positive_regulation	denotes	increase	true
T9682	647-651	Protein	denotes	pAkt
T9683	664-667	Protein	denotes	Akt
T9684	668-674	Binding	denotes	target
T9685	675-701	Protein	denotes	glycogen synthase kinase 3
T9686	703-707	Protein	denotes	GSK3
T9687	712-723	Negative_regulation	denotes	inactivated
T9688	753-762	Positive_regulation	denotes	increased	true
T9689	763-777	Phosphorylation	denotes	phosphorylated
T9690	778-782	Protein	denotes	GSK3
T9691	917-921	Protein	denotes	GSK3
T9692	931-937	Binding	denotes	target	true
T9693	941-950	Positive_regulation	denotes	activated
T9694	951-954	Protein	denotes	Akt
T9695	962-966	Protein	denotes	LMP1
T9696	1021-1031	Positive_regulation	denotes	activation
T9697	1035-1038	Protein	denotes	Akt
T9698	1047-1062	Phosphorylation	denotes	phosphorylation
T9699	1066-1070	Protein	denotes	GSK3
T9700	1168-1177	Positive_regulation	denotes	activated	true
T9701	1178-1181	Protein	denotes	Akt
T9702	1206-1220	Phosphorylation	denotes	phosphorylated
T9703	1221-1225	Protein	denotes	GSK3
T9704	1294-1304	Regulation	denotes	regulation
T9705	1308-1312	Protein	denotes	GSK3
T9706	2011-2014	Protein	denotes	Akt
T9707	2015-2022	Binding	denotes	targets		true
T9708	2048-2054	Protein	denotes	p-mTOR
T9709	2070-2079	Positive_regulation	denotes	Activated
T9710	2080-2086	Protein	denotes	p-mTOR
T9711	2095-2104	Positive_regulation	denotes	increased	true
T9712	2108-2112	Protein	denotes	LMP1
T9713	2191-2199	Regulation	denotes	affected	true
T9714	2203-2207	Protein	denotes	LMP1
T9715	2208-2215	Positive_regulation	denotes	induced
T9716	2216-2219	Protein	denotes	Akt
T9717	2220-2230	Positive_regulation	denotes	activation
T9718	2292-2295	Protein	denotes	Akt
T9719	2563-2568	Protein	denotes	FoxO1
T9720	2591-2598	Regulation	denotes	targets
T9721	2599-2604	Protein	denotes	FoxO1
T9722	2644-2649	Protein	denotes	FoxO1
T9723	2685-2690	Protein	denotes	FoxO1
T9724	2740-2745	Protein	denotes	FoxO1
T9725	2766-2775	Negative_regulation	denotes	decreased
T9726	2793-2797	Protein	denotes	LMP1
T9727	2919-2922	Protein	denotes	Akt
T9728	2974-2977	Protein	denotes	Akt
T9729	2978-2988	Positive_regulation	denotes	activation
T9730	2997-3003	Positive_regulation	denotes	induce	true
T9731	3004-3009	Protein	denotes	FoxO1
T9732	3010-3021	Negative_regulation	denotes	degradation
T9733	3025-3029	Protein	denotes	LMP1
T9734	3050-3053	Protein	denotes	Akt
T9735	3074-3083	Regulation	denotes	regulator	true	true
T9736	3087-3092	Protein	denotes	FoxO1
T9737	3247-3257	Gene_expression	denotes	expression
T9738	3279-3282	Protein	denotes	p27
T9739	3292-3296	Protein	denotes	LMP1
T9740	3357-3360	Protein	denotes	p27
T9741	3378-3382	Protein	denotes	Cdk2
T9742	3461-3463	Protein	denotes	Rb
T9743	3493-3497	Protein	denotes	LMP1
T9744	3541-3543	Protein	denotes	Rb
T9745	3588-3591	Protein	denotes	pRb
T9746	3593-3597	Protein	denotes	Cdk2
T9747	3603-3606	Protein	denotes	p27
T24344	1324-1328	Protein	denotes	LMP1
T24345	1339-1342	Protein	denotes	Akt
T24346	1373-1375	Protein	denotes	Rb
T24347	1446-1450	Protein	denotes	CD19
T24348	1480-1484	Protein	denotes	LMP1
T24349	1505-1508	Protein	denotes	Akt
T24350	1546-1550	Protein	denotes	pAkt
T24351	1566-1573	Regulation	denotes	targets
T24352	1566-1573	Regulation	denotes	targets
T24353	1585-1596	Positive_regulation	denotes	inactivated	true	true
T24354	1585-1596	Positive_regulation	denotes	inactivated	true	true
T24355	1597-1603	Protein	denotes	pGSK3α
T24356	1604-1605	Protein	denotes	β
T24357	1615-1624	Positive_regulation	denotes	activated		true
T24358	1625-1631	Protein	denotes	p-mTOR
T24359	1653-1658	Protein	denotes	FoxO1
T24360	1713-1717	Protein	denotes	GSK3
T24361	1853-1855	Protein	denotes	Rb
T24362	1877-1886	Positive_regulation	denotes	activated		true
T24363	1887-1890	Protein	denotes	pRb
T24364	1912-1916	Protein	denotes	Cdk2
T24365	1939-1942	Protein	denotes	p27
T9664	0-4	Protein	denotes	LMP1
T9665	15-18	Protein	denotes	Akt
T9666	49-51	Protein	denotes	Rb
T9667	71-75	Protein	denotes	LMP1
T9668	113-121	Positive_regulation	denotes	requires
T9669	122-132	Positive_regulation	denotes	activation
T9670	145-148	Protein	denotes	Akt
T9671	168-177	Positive_regulation	denotes	activated
T9672	178-182	Protein	denotes	pAkt
T9673	294-297	Protein	denotes	Akt
T9674	324-328	Protein	denotes	LMP1
T9675	346-350	Protein	denotes	pAkt
T9676	421-425	Protein	denotes	CD19
T9677	450-454	Protein	denotes	LMP1
T9678	478-487	Positive_regulation	denotes	increased
T9679	498-502	Protein	denotes	pAkt
T9748	3633-3637	Protein	denotes	CD19
T9749	3662-3666	Protein	denotes	LMP1
T9750	3690-3698	Positive_regulation	denotes	enhanced
T9751	3690-3698	Positive_regulation	denotes	enhanced
T9752	3709-3712	Protein	denotes	pRb
T9753	3753-3755	Protein	denotes	Rb
T9754	3767-3771	Protein	denotes	Cdk2
T9755	3867-3871	Protein	denotes	LMP1
T9756	3898-3901	Positive_regulation	denotes	led
T9757	3905-3914	Positive_regulation	denotes	increased
T9758	3925-3927	Protein	denotes	Rb
T9759	3945-3956	Positive_regulation	denotes	high levels
T9760	3960-3964	Protein	denotes	Cdk2
T9761	3970-3979	Negative_regulation	denotes	decreased
T9762	3990-3993	Protein	denotes	p27
T9763	4036-4038	Protein	denotes	Rb
T9764	4065-4069	Protein	denotes	LMP1
T9765	4138-4142	Negative_regulation	denotes	loss
T9766	4146-4151	Protein	denotes	FoxO1
T9767	4156-4165	Negative_regulation	denotes	decreased
T9768	4166-4169	Protein	denotes	p27
R7372	T9714	T9715	causeOf	LMP1,induced
R7373	T9715	T9713	causeOf	induced,affected
R7374	T9716	T9717	themeOf	Akt,activation
R7375	T9717	T9715	themeOf	activation,induced
R7376	T9721	T9720	themeOf	FoxO1,targets
R7377	T9724	T9725	themeOf	FoxO1,decreased
R7378	T9728	T9729	themeOf	Akt,activation
R7379	T9729	T9730	causeOf	activation,induce
R7380	T9731	T9732	themeOf	FoxO1,degradation
R7381	T9732	T9730	themeOf	degradation,induce
R7382	T9734	T9735	causeOf	Akt,regulator
R7383	T9736	T9735	themeOf	FoxO1,regulator
R7384	T9738	T9737	themeOf	p27,expression
R7385	T9752	T9750	themeOf	pRb,enhanced
R7386	T9754	T9751	themeOf	Cdk2,enhanced
R7387	T9757	T9756	themeOf	increased,led
R7388	T9758	T9757	themeOf	Rb,increased
R7389	T9760	T9759	themeOf	Cdk2,high levels
R7390	T9762	T9761	themeOf	p27,decreased
R7391	T9766	T9765	themeOf	FoxO1,loss
R7392	T9768	T9767	themeOf	p27,decreased
R18934	T24355	T24351	themeOf	pGSK3α,targets
R18935	T24355	T24354	themeOf	pGSK3α,inactivated
R18936	T24356	T24352	themeOf	β,targets
R18937	T24356	T24353	themeOf	β,inactivated
R18938	T24358	T24357	themeOf	p-mTOR,activated
R18939	T24363	T24362	themeOf	pRb,activated
R7355	T9684	T9687	themeOf	target,inactivated
R7356	T9685	T9684	themeOf	glycogen synthase kinase 3,target
R7358	T9689	T9688	themeOf	phosphorylated,increased
R7349	T9669	T9668	themeOf	activation,requires
R7350	T9670	T9669	themeOf	Akt,activation
R7351	T9672	T9671	themeOf	pAkt,activated
R7352	T9679	T9678	themeOf	pAkt,increased
R7353	T9682	T9681	themeOf	pAkt,increase
R7354	T9683	T9684	themeOf	Akt,target
R7357	T9686	T9685	equivalentTo	GSK3,glycogen synthase kinase 3
R7359	T9690	T9689	themeOf	GSK3,phosphorylated
R7360	T9691	T9692	themeOf	GSK3,target
R7361	T9694	T9692	themeOf	Akt,target
R7362	T9694	T9693	themeOf	Akt,activated
R7363	T9697	T9696	themeOf	Akt,activation
R7364	T9699	T9698	themeOf	GSK3,phosphorylation
R7365	T9701	T9700	themeOf	Akt,activated
R7366	T9703	T9702	themeOf	GSK3,phosphorylated
R7367	T9705	T9704	themeOf	GSK3,regulation
R7368	T9706	T9707	themeOf	Akt,targets
R7369	T9709	T9711	themeOf	Activated,increased
R7370	T9709	T9713	themeOf	Activated,affected
R7371	T9710	T9709	themeOf	p-mTOR,Activated

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T10395	0-4	P03230	denotes	LMP1
T10396	15-18	P31749	denotes	Akt
T10397	15-18	P31751	denotes	Akt
T10398	15-18	Q9Y243	denotes	Akt
T10399	49-51	P06400	denotes	Rb
T10400	71-75	P03230	denotes	LMP1
T10401	145-148	P31749	denotes	Akt
T10402	145-148	Q9Y243	denotes	Akt
T10403	145-148	P31751	denotes	Akt
T10404	178-182	P31751	denotes	pAkt
T10405	178-182	P31749	denotes	pAkt
T10406	178-182	Q9Y243	denotes	pAkt
T10407	294-297	Q9Y243	denotes	Akt
T10408	294-297	P31749	denotes	Akt
T10409	294-297	P31751	denotes	Akt
T10410	324-328	P03230	denotes	LMP1
T10411	346-350	P31749	denotes	pAkt
T10412	346-350	Q9Y243	denotes	pAkt
T10413	346-350	P31751	denotes	pAkt
T10414	421-425	P15391	denotes	CD19
T10415	450-454	P03230	denotes	LMP1
T10416	498-502	P31749	denotes	pAkt
T10417	498-502	Q9Y243	denotes	pAkt
T10418	498-502	P31751	denotes	pAkt
T10419	579-583	P03230	denotes	LMP1
T10420	647-651	P31751	denotes	pAkt
T10421	647-651	Q9Y243	denotes	pAkt
T10422	647-651	P31749	denotes	pAkt
T10423	664-667	Q9Y243	denotes	Akt
T10424	664-667	P31751	denotes	Akt
T10425	664-667	P31749	denotes	Akt
T10426	703-707	P49841	denotes	GSK3
T10427	703-707	P49840	denotes	GSK3
T10428	778-782	P49841	denotes	GSK3
T10429	778-782	P49840	denotes	GSK3
T10430	917-921	P49841	denotes	GSK3
T10431	917-921	P49840	denotes	GSK3
T10432	951-954	Q9Y243	denotes	Akt
T10433	951-954	P31749	denotes	Akt
T10434	951-954	P31751	denotes	Akt
T10435	962-966	P03230	denotes	LMP1
T10436	1035-1038	P31749	denotes	Akt
T10437	1035-1038	P31751	denotes	Akt
T10438	1035-1038	Q9Y243	denotes	Akt
T10439	1066-1070	P49841	denotes	GSK3
T10440	1066-1070	P49840	denotes	GSK3
T10441	1178-1181	Q9Y243	denotes	Akt
T10442	1178-1181	P31749	denotes	Akt
T10443	1178-1181	P31751	denotes	Akt
T10444	1221-1225	P49841	denotes	GSK3
T10445	1221-1225	P49840	denotes	GSK3
T10446	1308-1312	P49840	denotes	GSK3
T10447	1308-1312	P49841	denotes	GSK3
T10448	2011-2014	Q9Y243	denotes	Akt
T10449	2011-2014	P31751	denotes	Akt
T10450	2011-2014	P31749	denotes	Akt
T10451	2050-2054	P42345	denotes	mTOR
T10452	2082-2086	P42345	denotes	mTOR
T10453	2108-2112	P03230	denotes	LMP1
T10454	2203-2207	P03230	denotes	LMP1
T10455	2216-2219	P31751	denotes	Akt
T10456	2216-2219	P31749	denotes	Akt
T10457	2216-2219	Q9Y243	denotes	Akt
T10458	2292-2295	P31751	denotes	Akt
T10459	2292-2295	P31749	denotes	Akt
T10460	2292-2295	Q9Y243	denotes	Akt
T10461	2563-2568	Q12778	denotes	FoxO1
T10462	2599-2604	Q12778	denotes	FoxO1
T10463	2644-2649	Q12778	denotes	FoxO1
T10464	2685-2690	Q12778	denotes	FoxO1
T10465	2740-2745	Q12778	denotes	FoxO1
T10466	2793-2797	P03230	denotes	LMP1
T10467	2919-2922	P31749	denotes	Akt
T10468	2919-2922	Q9Y243	denotes	Akt
T10469	2919-2922	P31751	denotes	Akt
T10470	2974-2977	P31751	denotes	Akt
T10471	2974-2977	P31749	denotes	Akt
T10472	2974-2977	Q9Y243	denotes	Akt
T10473	3004-3009	Q12778	denotes	FoxO1
T10474	3025-3029	P03230	denotes	LMP1
T10475	3050-3053	P31751	denotes	Akt
T10476	3050-3053	Q9Y243	denotes	Akt
T10477	3050-3053	P31749	denotes	Akt
T10478	3087-3092	Q12778	denotes	FoxO1
T10479	3279-3282	P46527	denotes	p27
T10480	3292-3296	P03230	denotes	LMP1
T10481	3357-3360	P46527	denotes	p27
T10482	3378-3382	P24941	denotes	Cdk2
T10483	3461-3463	P06400	denotes	Rb
T10484	3493-3497	P03230	denotes	LMP1
T10485	3541-3543	P06400	denotes	Rb
T10486	3588-3591	P06400	denotes	pRb
T10487	3593-3597	P24941	denotes	Cdk2
T10488	3603-3606	P46527	denotes	p27
T10489	3633-3637	P15391	denotes	CD19
T10490	3662-3666	P03230	denotes	LMP1
T10491	3709-3712	P06400	denotes	pRb
T10492	3753-3755	P06400	denotes	Rb
T10493	3767-3771	P24941	denotes	Cdk2
T10494	3867-3871	P03230	denotes	LMP1
T10495	3925-3927	P06400	denotes	Rb
T10496	3960-3964	P24941	denotes	Cdk2
T10497	3990-3993	P46527	denotes	p27
T10498	4036-4038	P06400	denotes	Rb
T10499	4065-4069	P03230	denotes	LMP1
T10500	4146-4151	Q12778	denotes	FoxO1
T10501	4166-4169	P46527	denotes	p27
T24499	1324-1328	P03230	denotes	LMP1
T24500	1339-1342	P31751	denotes	Akt
T24501	1339-1342	Q9Y243	denotes	Akt
T24502	1339-1342	P31749	denotes	Akt
T24503	1373-1375	P06400	denotes	Rb
T24504	1446-1450	P15391	denotes	CD19
T24505	1480-1484	P03230	denotes	LMP1
T24506	1505-1508	P31751	denotes	Akt
T24507	1505-1508	P31749	denotes	Akt
T24508	1505-1508	Q9Y243	denotes	Akt
T24509	1546-1550	Q9Y243	denotes	pAkt
T24510	1546-1550	P31751	denotes	pAkt
T24511	1546-1550	P31749	denotes	pAkt
T24512	1627-1631	P42345	denotes	mTOR
T24513	1653-1658	Q12778	denotes	FoxO1
T24514	1713-1717	P49841	denotes	GSK3
T24515	1713-1717	P49840	denotes	GSK3
T24516	1853-1855	P06400	denotes	Rb
T24517	1887-1890	P06400	denotes	pRb
T24518	1912-1916	P24941	denotes	Cdk2
T24519	1939-1942	P46527	denotes	p27

test2

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T9551	0-4	Protein	denotes	LMP1
T9552	15-18	Protein	denotes	Akt
T9553	49-51	Protein	denotes	Rb
T9554	71-75	Protein	denotes	LMP1
T9555	122-132	Positive_regulation	denotes	activation	true
T9556	145-148	Protein	denotes	Akt
T9557	168-177	Positive_regulation	denotes	activated
T9558	178-182	Protein	denotes	pAkt	true
T9559	294-297	Protein	denotes	Akt
T9560	311-320	Positive_regulation	denotes	activated	true
T9561	324-328	Protein	denotes	LMP1
T9562	346-350	Protein	denotes	pAkt
T9563	421-425	Protein	denotes	CD19
T9564	450-454	Protein	denotes	LMP1	true
T9565	478-487	Positive_regulation	denotes	increased
T9566	498-502	Protein	denotes	pAkt
T9567	579-583	Protein	denotes	LMP1		true
T9568	584-592	Gene_expression	denotes	positive
T9569	638-646	Positive_regulation	denotes	increase	true
T9570	647-651	Protein	denotes	pAkt	true
T9571	664-667	Protein	denotes	Akt
T9572	675-701	Protein	denotes	glycogen synthase kinase 3
T9573	703-707	Protein	denotes	GSK3
T9574	712-723	Negative_regulation	denotes	inactivated
T9575	727-742	Phosphorylation	denotes	phosphorylation
T9576	753-762	Positive_regulation	denotes	increased	true
T9577	763-777	Phosphorylation	denotes	phosphorylated
T9578	778-782	Protein	denotes	GSK3	true	true
T9579	917-921	Protein	denotes	GSK3
T9580	931-937	Binding	denotes	target
T9581	941-950	Positive_regulation	denotes	activated
T9582	951-954	Protein	denotes	Akt
T9583	962-966	Protein	denotes	LMP1
T9584	1021-1031	Positive_regulation	denotes	activation
T9585	1035-1038	Protein	denotes	Akt
T9586	1047-1062	Phosphorylation	denotes	phosphorylation
T9587	1066-1070	Protein	denotes	GSK3
T9588	1168-1177	Positive_regulation	denotes	activated
T9589	1178-1181	Protein	denotes	Akt
T9590	1206-1220	Phosphorylation	denotes	phosphorylated
T9591	1221-1225	Protein	denotes	GSK3
T9592	1294-1304	Regulation	denotes	regulation
T9593	1308-1312	Protein	denotes	GSK3
T9594	2011-2014	Protein	denotes	Akt
T9595	2015-2022	Binding	denotes	targets
T9596	2048-2054	Protein	denotes	p-mTOR
T9597	2070-2079	Positive_regulation	denotes	Activated
T9598	2080-2086	Protein	denotes	p-mTOR
T9599	2095-2104	Positive_regulation	denotes	increased
T9600	2108-2112	Protein	denotes	LMP1
T9601	2191-2199	Regulation	denotes	affected
T9602	2203-2207	Protein	denotes	LMP1
T9603	2208-2215	Positive_regulation	denotes	induced
T9604	2216-2219	Protein	denotes	Akt
T9605	2220-2230	Positive_regulation	denotes	activation
T9606	2292-2295	Protein	denotes	Akt
T9607	2313-2326	Phosphorylation	denotes	phosphorylate
T9608	2563-2568	Protein	denotes	FoxO1
T9609	2599-2604	Protein	denotes	FoxO1
T9610	2609-2620	Protein_catabolism	denotes	degradation
T9611	2629-2640	Protein_catabolism	denotes	degradation
T9612	2644-2649	Protein	denotes	FoxO1
T9613	2685-2690	Protein	denotes	FoxO1
T9614	2740-2745	Protein	denotes	FoxO1
T9615	2766-2775	Negative_regulation	denotes	decreased
T9616	2793-2797	Protein	denotes	LMP1
T9617	2909-2915	Binding	denotes	target
T9618	2919-2922	Protein	denotes	Akt
T9619	2974-2977	Protein	denotes	Akt
T9620	2978-2988	Positive_regulation	denotes	activation
T9621	2997-3003	Positive_regulation	denotes	induce
T9622	3004-3009	Protein	denotes	FoxO1
T9623	3010-3021	Protein_catabolism	denotes	degradation
T9624	3025-3029	Protein	denotes	LMP1
T9625	3050-3053	Protein	denotes	Akt
T9626	3074-3083	Regulation	denotes	regulator
T9627	3087-3092	Protein	denotes	FoxO1
T9628	3236-3242	Positive_regulation	denotes	induce
T9629	3247-3257	Gene_expression	denotes	expression
T9630	3269-3278	Negative_regulation	denotes	inhibitor
T9631	3279-3282	Protein	denotes	p27
T9632	3292-3296	Protein	denotes	LMP1
T9633	3333-3342	Negative_regulation	denotes	decreased
T9634	3343-3353	Gene_expression	denotes	expression
T9635	3357-3360	Protein	denotes	p27
T9636	3362-3374	Positive_regulation	denotes	upregulation
T9637	3378-3382	Protein	denotes	Cdk2
T9638	3461-3463	Protein	denotes	Rb
T9639	3493-3497	Protein	denotes	LMP1
T9640	3541-3543	Protein	denotes	Rb
T9641	3588-3591	Protein	denotes	pRb
T9642	3593-3597	Protein	denotes	Cdk2
T9643	3603-3606	Protein	denotes	p27
T9644	3633-3637	Protein	denotes	CD19
T9645	3662-3666	Protein	denotes	LMP1
T9646	3690-3698	Positive_regulation	denotes	enhanced
T9647	3709-3712	Protein	denotes	pRb
T9648	3753-3755	Protein	denotes	Rb
T9649	3767-3771	Protein	denotes	Cdk2
T9650	3867-3871	Protein	denotes	LMP1
T9651	3898-3901	Positive_regulation	denotes	led
T9652	3905-3914	Positive_regulation	denotes	increased
T9653	3925-3927	Protein	denotes	Rb
T9654	3945-3949	Positive_regulation	denotes	high
T9655	3960-3964	Protein	denotes	Cdk2
T9656	3970-3979	Negative_regulation	denotes	decreased
T9657	3990-3993	Protein	denotes	p27
T9658	4036-4038	Protein	denotes	Rb
T9659	4065-4069	Protein	denotes	LMP1
T9660	4138-4142	Negative_regulation	denotes	loss
T9661	4146-4151	Protein	denotes	FoxO1
T9662	4156-4165	Negative_regulation	denotes	decreased
T9663	4166-4169	Protein	denotes	p27
T24322	1324-1328	Protein	denotes	LMP1
T24323	1339-1342	Protein	denotes	Akt
T24324	1373-1375	Protein	denotes	Rb	true	true
T24325	1446-1450	Protein	denotes	CD19	true	true
T24326	1480-1484	Protein	denotes	LMP1		true
T24327	1505-1508	Protein	denotes	Akt		true
T24328	1536-1545	Positive_regulation	denotes	activated
T24329	1546-1550	Protein	denotes	pAkt
T24330	1585-1596	Negative_regulation	denotes	inactivated
T24331	1597-1603	Protein	denotes	pGSK3α
T24332	1604-1605	Protein	denotes	β
T24333	1615-1624	Positive_regulation	denotes	activated
T24334	1625-1631	Protein	denotes	p-mTOR
T24335	1653-1658	Protein	denotes	FoxO1
T24336	1713-1717	Protein	denotes	GSK3
T24337	1853-1855	Protein	denotes	Rb
T24338	1877-1886	Positive_regulation	denotes	activated
T24339	1887-1890	Protein	denotes	pRb
T24340	1912-1916	Protein	denotes	Cdk2
T24341	1929-1938	Negative_regulation	denotes	inhibitor
T24342	1939-1942	Protein	denotes	p27
R7305	T9556	T9555	themeOf	Akt,activation
R7306	T9558	T9557	themeOf	pAkt,activated
R7307	T9566	T9565	themeOf	pAkt,increased
R7308	T9567	T9568	themeOf	LMP1,positive
R7309	T9570	T9569	themeOf	pAkt,increase
R7310	T9573	T9572	equivalentTo	GSK3,glycogen synthase kinase 3
R7311	T9577	T9576	themeOf	phosphorylated,increased
R7312	T9578	T9577	themeOf	GSK3,phosphorylated
R7313	T9579	T9580	themeOf	GSK3,target
R7314	T9582	T9581	themeOf	Akt,activated
R7315	T9582	T9580	themeOf	Akt,target
R7316	T9585	T9584	themeOf	Akt,activation
R7317	T9587	T9586	themeOf	GSK3,phosphorylation
R7318	T9589	T9588	themeOf	Akt,activated
R7319	T9591	T9590	themeOf	GSK3,phosphorylated
R7320	T9593	T9592	themeOf	GSK3,regulation
R7321	T9594	T9595	themeOf	Akt,targets
R7322	T9596	T9595	themeOf	p-mTOR,targets
R7323	T9597	T9599	themeOf	Activated,increased
R7324	T9598	T9597	themeOf	p-mTOR,Activated
R7325	T9598	T9599	themeOf	p-mTOR,increased
R7326	T9602	T9603	causeOf	LMP1,induced
R7327	T9604	T9605	themeOf	Akt,activation
R7328	T9605	T9603	themeOf	activation,induced
R7329	T9609	T9610	themeOf	FoxO1,degradation
R7330	T9612	T9611	themeOf	FoxO1,degradation
R7331	T9614	T9615	themeOf	FoxO1,decreased
R7332	T9618	T9617	themeOf	Akt,target
R7333	T9619	T9620	themeOf	Akt,activation
R7334	T9620	T9621	causeOf	activation,induce
R7335	T9622	T9623	themeOf	FoxO1,degradation
R7336	T9623	T9621	themeOf	degradation,induce
R7337	T9625	T9626	causeOf	Akt,regulator
R7338	T9627	T9626	themeOf	FoxO1,regulator
R7339	T9629	T9628	themeOf	expression,induce
R7340	T9631	T9630	themeOf	p27,inhibitor
R7341	T9631	T9629	themeOf	p27,expression
R7342	T9634	T9633	themeOf	expression,decreased
R7343	T9647	T9646	themeOf	pRb,enhanced
R7344	T9652	T9651	themeOf	increased,led
R7345	T9653	T9652	themeOf	Rb,increased
R7346	T9657	T9656	themeOf	p27,decreased
R7347	T9661	T9660	themeOf	FoxO1,loss
R7348	T9663	T9662	themeOf	p27,decreased
R18927	T24329	T24328	themeOf	pAkt,activated
R18928	T24331	T24330	themeOf	pGSK3α,inactivated
R18929	T24332	T24330	themeOf	β,inactivated
R18930	T24334	T24333	themeOf	p-mTOR,activated
R18931	T24339	T24338	themeOf	pRb,activated
R18932	T24340	T24341	themeOf	Cdk2,inhibitor
R18933	T24342	T24341	themeOf	p27,inhibitor

PMC:2065877 / 24399-28569 JSONTXT

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