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2_test

Id Subject Object Predicate Lexical cue
17997602-3022942-98185704 470-471 3022942 denotes 3
17997602-8396685-98185705 1118-1119 8396685 denotes 4
17997602-16007144-98185705 1118-1119 16007144 denotes 4
17997602-7778675-98185705 1118-1119 7778675 denotes 4
17997602-3000618-98185705 1118-1119 3000618 denotes 4
17997602-2552313-98185705 1118-1119 2552313 denotes 4
17997602-12805559-98185706 1247-1248 12805559 denotes 9
17997602-8415670-98185706 1247-1248 8415670 denotes 9
17997602-7859281-98185706 1247-1248 7859281 denotes 9
17997602-8943365-98185707 1641-1643 8943365 denotes 12
17997602-9882303-98185707 1641-1643 9882303 denotes 12
17997602-14576817-98185707 1641-1643 14576817 denotes 12
17997602-9570524-98185707 1641-1643 9570524 denotes 12
17997602-9566902-98185707 1641-1643 9566902 denotes 12
17997602-10811897-98185708 1768-1770 10811897 denotes 17
17997602-15047827-98185709 1771-1773 15047827 denotes 18
17997602-16007144-98185710 1969-1970 16007144 denotes 5
17997602-12446712-98185711 1971-1973 12446712 denotes 19
17997602-7534202-98185712 2252-2254 7534202 denotes 20
17997602-7882172-98185713 2255-2257 7882172 denotes 21
17997602-11867568-98185714 2531-2533 11867568 denotes 22
17997602-10514374-98185715 2864-2866 10514374 denotes 23
17997602-9768760-98185716 3072-3074 9768760 denotes 24
17997602-15640350-98185716 3072-3074 15640350 denotes 24
17997602-9751773-98185716 3072-3074 9751773 denotes 24
17997602-9751773-98185717 3325-3327 9751773 denotes 26
17997602-16247482-98185718 3475-3477 16247482 denotes 27
17997602-7536467-98185719 3939-3941 7536467 denotes 28
17997602-1370214-98185720 3942-3944 1370214 denotes 29

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T880 13-25 JJ denotes Epstein-Barr
T881 26-31 NN denotes virus
T882 32-33 -LRB- denotes (
T883 33-36 NN denotes EBV
T884 36-37 -RRB- denotes )
T885 38-40 VB denotes is
T886 41-42 DT denotes a
T887 43-53 JJ denotes ubiquitous
T888 54-67 NN denotes γ-herpesvirus
T889 68-72 WDT denotes that
T890 73-80 VB denotes infects
T891 81-87 NN denotes humans
T892 88-101 RB denotes predominantly
T893 102-104 IN denotes at
T894 105-107 DT denotes an
T895 108-113 JJ denotes early
T896 114-117 NN denotes age
T897 118-122 IN denotes with
T898 123-130 JJ denotes greater
T899 131-135 IN denotes than
T900 136-138 CD denotes 90
T901 138-139 NN denotes %
T902 140-142 IN denotes of
T903 143-146 DT denotes the
T904 147-152 JJ denotes adult
T905 153-163 NN denotes population
T906 164-172 VB denotes infected
T907 173-177 IN denotes with
T908 178-181 NN denotes EBV
T909 182-183 -LRB- denotes [
T910 183-184 CD denotes 1
T911 184-185 -RRB- denotes ]
T912 187-190 NN denotes EBV
T913 191-193 VB denotes is
T914 194-200 VB denotes linked
T915 201-203 TO denotes to
T916 204-207 DT denotes the
T917 208-219 NN denotes development
T918 220-222 IN denotes of
T919 223-227 CC denotes both
T920 228-229 NN denotes B
T921 230-240 NN denotes lymphocyte
T922 241-244 CC denotes and
T923 245-255 JJ denotes epithelial
T924 256-260 NN denotes cell
T925 261-273 NN denotes malignancies
T926 273-274 -COMMA- denotes ,
T927 275-284 VB denotes including
T928 285-292 NN denotes Burkitt
T929 293-301 NN denotes lymphoma
T930 301-302 -COMMA- denotes ,
T931 303-310 NN denotes Hodgkin
T932 311-318 NN denotes disease
T933 319-320 -LRB- denotes (
T934 320-322 NN denotes HD
T935 322-323 -RRB- denotes )
T936 323-324 -COMMA- denotes ,
T937 325-328 CC denotes and
T938 329-343 JJ denotes nasopharyngeal
T939 344-353 NN denotes carcinoma
T940 354-355 -LRB- denotes (
T941 355-358 NN denotes NPC
T942 358-359 -RRB- denotes )
T943 359-360 -COMMA- denotes ,
T944 361-364 CC denotes and
T945 365-372 NN denotes cancers
T946 373-379 VB denotes linked
T947 380-382 TO denotes to
T948 383-400 NN denotes immunosuppression
T949 400-401 -COMMA- denotes ,
T950 402-411 VB denotes including
T951 412-427 JJ denotes post-transplant
T952 428-436 NN denotes lymphoma
T953 437-440 CC denotes and
T954 441-456 JJ denotes AIDS-associated
T955 457-466 NN denotes lymphomas
T956 467-468 -LRB- denotes [
T957 468-471 CD denotes 2,3
T958 471-472 -RRB- denotes ]
T959 474-476 FW denotes In
T960 477-482 FW denotes vitro
T961 483-492 NN denotes infection
T962 493-495 IN denotes of
T963 496-497 NN denotes B
T964 498-509 NN denotes lymphocytes
T965 510-514 IN denotes with
T966 515-518 NN denotes EBV
T967 519-526 VB denotes induces
T968 527-536 JJ denotes permanent
T969 537-543 NN denotes growth
T970 544-558 NN denotes transformation
T971 558-559 -COMMA- denotes ,
T972 560-563 CC denotes and
T973 564-568 DT denotes this
T974 569-576 NN denotes ability
T975 577-579 TO denotes to
T976 580-586 VB denotes affect
T977 587-591 NN denotes cell
T978 592-598 NN denotes growth
T979 599-609 NN denotes regulation
T980 610-616 RB denotes likely
T981 617-628 VB denotes contributes
T982 629-631 TO denotes to
T983 632-635 DT denotes the
T984 636-647 NN denotes development
T985 648-650 IN denotes of
T986 651-657 NN denotes cancer
T987 659-663 JJ denotes Many
T988 664-666 IN denotes of
T989 667-670 DT denotes the
T990 671-676 JJ denotes viral
T991 677-685 NN denotes proteins
T992 686-695 VB denotes expressed
T993 696-698 IN denotes in
T994 699-710 VB denotes transformed
T995 711-716 NN denotes cells
T996 716-717 -COMMA- denotes ,
T997 718-727 VB denotes including
T998 728-731 DT denotes the
T999 732-735 NN denotes EBV
T1000 736-743 JJ denotes nuclear
T1001 744-752 NN denotes antigens
T1002 753-756 CC denotes and
T1003 757-763 JJ denotes latent
T1004 764-772 NN denotes membrane
T1005 773-781 NN denotes proteins
T1006 781-782 -COMMA- denotes ,
T1007 783-787 VB denotes have
T1008 788-796 JJ denotes profound
T1009 797-804 NN denotes effects
T1010 805-807 IN denotes on
T1011 808-812 NN denotes cell
T1012 813-819 NN denotes growth
T1013 820-830 NN denotes regulation
T1014 831-834 CC denotes and
T1015 835-838 VB denotes are
T1016 839-847 VB denotes required
T1017 848-851 IN denotes for
T1018 852-855 NN denotes EBV
T1019 856-862 JJ denotes latent
T1020 863-872 NN denotes infection
T1021 873-876 CC denotes and
T1022 877-878 NN denotes B
T1023 879-883 NN denotes cell
T1024 884-898 NN denotes transformation
T1025 899-900 -LRB- denotes [
T1026 900-901 CD denotes 1
T1027 901-902 -RRB- denotes ]
T1028 904-910 JJ denotes Latent
T1029 911-919 NN denotes membrane
T1030 920-927 NN denotes protein
T1031 928-929 CD denotes 1
T1032 930-931 -LRB- denotes (
T1033 931-935 NN denotes LMP1
T1034 935-936 -RRB- denotes )
T1035 937-939 VB denotes is
T1036 940-950 VB denotes considered
T1037 951-954 DT denotes the
T1038 955-960 JJ denotes major
T1039 961-972 NN denotes oncoprotein
T1040 973-975 IN denotes of
T1041 976-979 NN denotes EBV
T1042 979-980 -COMMA- denotes ,
T1043 981-983 IN denotes as
T1044 984-986 PRP denotes it
T1045 987-997 VB denotes transforms
T1046 998-1004 JJ denotes rodent
T1047 1005-1016 NN denotes fibroblasts
T1048 1017-1019 TO denotes to
T1049 1020-1034 NN denotes tumorigenicity
T1050 1035-1037 IN denotes in
T1051 1038-1042 JJ denotes nude
T1052 1043-1047 NN denotes mice
T1053 1048-1051 CC denotes and
T1054 1052-1054 VB denotes is
T1055 1055-1064 VB denotes expressed
T1056 1065-1067 IN denotes in
T1057 1068-1070 NN denotes HD
T1058 1070-1071 -COMMA- denotes ,
T1059 1072-1075 NN denotes NPC
T1060 1075-1076 -COMMA- denotes ,
T1061 1077-1080 CC denotes and
T1062 1081-1109 JJ denotes immunosuppression-associated
T1063 1110-1116 NN denotes tumors
T1064 1117-1118 -LRB- denotes [
T1065 1118-1121 CD denotes 4–8
T1066 1121-1122 -RRB- denotes ]
T1067 1124-1126 IN denotes In
T1068 1127-1128 NN denotes B
T1069 1129-1140 NN denotes lymphocytes
T1070 1140-1141 -COMMA- denotes ,
T1071 1142-1146 NN denotes LMP1
T1072 1147-1153 VB denotes mimics
T1073 1154-1158 NN denotes CD40
T1074 1159-1168 NN denotes signaling
T1075 1168-1169 -COMMA- denotes ,
T1076 1170-1173 CC denotes and
T1077 1174-1178 CC denotes both
T1078 1179-1183 NN denotes LMP1
T1079 1184-1187 CC denotes and
T1080 1188-1192 NN denotes CD40
T1081 1193-1196 VB denotes are
T1082 1197-1206 JJ denotes essential
T1083 1207-1210 IN denotes for
T1084 1211-1223 JJ denotes EBV-mediated
T1085 1224-1225 NN denotes B
T1086 1226-1230 NN denotes cell
T1087 1231-1245 NN denotes transformation
T1088 1246-1247 -LRB- denotes [
T1089 1247-1251 CD denotes 9–11
T1090 1251-1252 -RRB- denotes ]
T1091 1254-1259 IN denotes While
T1092 1260-1264 NN denotes CD40
T1093 1265-1274 VB denotes interacts
T1094 1275-1279 IN denotes with
T1095 1280-1284 NN denotes CD40
T1096 1285-1291 NN denotes ligand
T1097 1292-1301 VB denotes expressed
T1098 1302-1304 IN denotes on
T1099 1305-1314 VB denotes activated
T1100 1315-1316 NN denotes T
T1101 1317-1322 NN denotes cells
T1102 1323-1325 TO denotes to
T1103 1326-1332 VB denotes induce
T1104 1333-1334 NN denotes B
T1105 1335-1339 NN denotes cell
T1106 1340-1350 NN denotes activation
T1107 1351-1354 CC denotes and
T1108 1355-1370 NN denotes differentiation
T1109 1370-1371 -COMMA- denotes ,
T1110 1372-1376 NN denotes LMP1
T1111 1377-1381 VB denotes acts
T1112 1382-1384 IN denotes as
T1113 1385-1386 DT denotes a
T1114 1387-1399 JJ denotes constitutive
T1115 1400-1406 NN denotes signal
T1116 1407-1414 IN denotes through
T1117 1415-1433 JJ denotes ligand-independent
T1118 1434-1449 NN denotes oligomerization
T1119 1451-1455 NN denotes LMP1
T1120 1456-1459 CC denotes and
T1121 1460-1464 NN denotes CD40
T1122 1465-1473 VB denotes interact
T1123 1474-1478 IN denotes with
T1124 1479-1482 DT denotes the
T1125 1483-1487 JJ denotes same
T1126 1488-1493 NN denotes tumor
T1127 1494-1502 NN denotes necrosis
T1128 1503-1509 NN denotes factor
T1129 1510-1529 VB denotes receptor–associated
T1130 1530-1537 NN denotes factors
T1131 1538-1539 -LRB- denotes (
T1132 1539-1544 NN denotes TRAFs
T1133 1544-1545 -RRB- denotes )
T1134 1546-1553 VB denotes leading
T1135 1554-1556 TO denotes to
T1136 1557-1567 NN denotes activation
T1137 1568-1570 IN denotes of
T1138 1571-1575 NN denotes NFκB
T1139 1575-1576 -COMMA- denotes ,
T1140 1577-1582 NN denotes c-Jun
T1141 1583-1584 NN denotes N
T1142 1585-1593 JJ denotes terminal
T1143 1594-1600 NN denotes kinase
T1144 1601-1602 -LRB- denotes (
T1145 1602-1605 NN denotes JNK
T1146 1605-1606 -RRB- denotes )
T1147 1606-1607 -COMMA- denotes ,
T1148 1608-1611 CC denotes and
T1149 1612-1615 NN denotes p38
T1150 1616-1620 NN denotes MAPK
T1151 1621-1630 NN denotes signaling
T1152 1631-1639 NN denotes pathways
T1153 1640-1641 -LRB- denotes [
T1154 1641-1646 CD denotes 12–16
T1155 1646-1647 -RRB- denotes ]
T1156 1649-1659 NN denotes Activation
T1157 1660-1662 IN denotes of
T1158 1663-1667 NN denotes NFκB
T1159 1668-1670 VB denotes is
T1160 1671-1679 VB denotes required
T1161 1680-1683 IN denotes for
T1162 1684-1695 JJ denotes EBV-induced
T1163 1696-1697 NN denotes B
T1164 1698-1702 NN denotes cell
T1165 1703-1717 NN denotes transformation
T1166 1718-1721 CC denotes and
T1167 1722-1725 PRP-DOLLAR- denotes its
T1168 1726-1736 NN denotes inhibition
T1169 1737-1744 RB denotes rapidly
T1170 1745-1752 VB denotes results
T1171 1753-1755 IN denotes in
T1172 1756-1760 NN denotes cell
T1173 1761-1766 NN denotes death
T1174 1767-1768 -LRB- denotes [
T1175 1768-1773 CD denotes 17,18
T1176 1773-1774 -RRB- denotes ]
T1177 1776-1782 JJ denotes Recent
T1178 1783-1790 NN denotes studies
T1179 1791-1799 VB denotes indicate
T1180 1800-1804 IN denotes that
T1181 1805-1809 NN denotes LMP1
T1182 1810-1814 RB denotes also
T1183 1815-1824 VB denotes activates
T1184 1825-1845 NN denotes phosphatidylinositol
T1185 1846-1847 CD denotes 3
T1186 1848-1854 NN denotes kinase
T1187 1855-1856 -LRB- denotes (
T1188 1856-1860 NN denotes PI3K
T1189 1860-1861 -RRB- denotes )
T1190 1861-1865 NN denotes /Akt
T1191 1866-1875 NN denotes signaling
T1192 1876-1879 CC denotes and
T1193 1880-1884 IN denotes that
T1194 1885-1889 DT denotes this
T1195 1890-1900 NN denotes activation
T1196 1901-1903 VB denotes is
T1197 1904-1912 VB denotes required
T1198 1913-1916 IN denotes for
T1199 1917-1930 JJ denotes LMP1-mediated
T1200 1931-1945 NN denotes transformation
T1201 1946-1948 IN denotes of
T1202 1949-1955 JJ denotes rodent
T1203 1956-1967 NN denotes fibroblasts
T1204 1968-1969 -LRB- denotes [
T1205 1969-1973 CD denotes 5,19
T1206 1973-1974 -RRB- denotes ]
T1207 1976-1978 FW denotes In
T1208 1979-1984 FW denotes vitro
T1209 1984-1985 -COMMA- denotes ,
T1210 1986-1993 JJ denotes primary
T1211 1994-1995 NN denotes B
T1212 1996-2001 NN denotes cells
T1213 2002-2005 MD denotes can
T1214 2006-2008 VB denotes be
T1215 2009-2019 VB denotes maintained
T1216 2020-2022 IN denotes by
T1217 2023-2027 NN denotes CD40
T1218 2028-2036 NN denotes ligation
T1219 2037-2039 IN denotes in
T1220 2040-2051 NN denotes combination
T1221 2052-2056 IN denotes with
T1222 2057-2060 NN denotes IL4
T1223 2061-2070 NN denotes treatment
T1224 2072-2074 FW denotes In
T1225 2075-2079 FW denotes vivo
T1226 2079-2080 -COMMA- denotes ,
T1227 2081-2085 NN denotes CD40
T1228 2086-2095 NN denotes signaling
T1229 2096-2098 VB denotes is
T1230 2099-2108 JJ denotes necessary
T1231 2109-2112 IN denotes for
T1232 2113-2121 JJ denotes germinal
T1233 2122-2128 NN denotes center
T1234 2129-2130 -LRB- denotes (
T1235 2130-2132 NN denotes GC
T1236 2132-2133 -RRB- denotes )
T1237 2134-2143 NN denotes formation
T1238 2144-2148 JJ denotes such
T1239 2149-2153 IN denotes that
T1240 2154-2158 NN denotes mice
T1241 2159-2168 JJ denotes deficient
T1242 2169-2172 IN denotes for
T1243 2173-2177 NN denotes CD40
T1244 2178-2180 CC denotes or
T1245 2181-2186 NN denotes CD40L
T1246 2187-2190 VB denotes are
T1247 2191-2197 JJ denotes unable
T1248 2198-2200 TO denotes to
T1249 2201-2205 VB denotes form
T1250 2206-2209 NN denotes GCs
T1251 2210-2212 IN denotes in
T1252 2213-2221 NN denotes response
T1253 2222-2224 TO denotes to
T1254 2225-2226 NN denotes T
T1255 2227-2241 JJ denotes cell–dependent
T1256 2242-2250 NN denotes antigens
T1257 2251-2252 -LRB- denotes [
T1258 2252-2257 CD denotes 20,21
T1259 2257-2258 -RRB- denotes ]
T1260 2260-2264 CC denotes Both
T1261 2265-2268 DT denotes the
T1262 2269-2277 NN denotes membrane
T1263 2278-2286 JJ denotes proximal
T1264 2287-2290 CC denotes and
T1265 2291-2297 JJ denotes distal
T1266 2298-2309 JJ denotes cytoplasmic
T1267 2310-2317 NN denotes regions
T1268 2318-2320 IN denotes of
T1269 2321-2325 NN denotes CD40
T1270 2326-2330 WDT denotes that
T1271 2331-2335 VB denotes bind
T1272 2336-2341 NN denotes TRAF6
T1273 2342-2345 CC denotes and
T1274 2346-2356 NN denotes TRAFs2/3/5
T1275 2356-2357 -COMMA- denotes ,
T1276 2358-2370 RB denotes respectively
T1277 2370-2371 -COMMA- denotes ,
T1278 2372-2375 VB denotes are
T1279 2376-2385 JJ denotes necessary
T1280 2386-2389 IN denotes for
T1281 2390-2392 NN denotes GC
T1282 2393-2402 NN denotes formation
T1283 2402-2403 -COMMA- denotes ,
T1284 2404-2407 CC denotes but
T1285 2408-2414 CC denotes either
T1286 2415-2421 NN denotes region
T1287 2422-2424 VB denotes is
T1288 2425-2435 JJ denotes sufficient
T1289 2436-2438 TO denotes to
T1290 2439-2445 VB denotes induce
T1291 2446-2461 JJ denotes extrafollicular
T1292 2462-2463 NN denotes B
T1293 2464-2468 NN denotes cell
T1294 2469-2484 NN denotes differentiation
T1295 2485-2488 CC denotes and
T1296 2489-2496 VB denotes restore
T1297 2497-2500 JJ denotes low
T1298 2501-2509 NN denotes affinity
T1299 2510-2518 NN denotes antibody
T1300 2519-2529 NN denotes production
T1301 2530-2531 -LRB- denotes [
T1302 2531-2533 CD denotes 22
T1303 2533-2534 -RRB- denotes ]
T1304 2536-2548 RB denotes Functionally
T1305 2548-2549 -COMMA- denotes ,
T1306 2550-2554 NN denotes LMP1
T1307 2555-2558 MD denotes can
T1308 2559-2565 VB denotes rescue
T1309 2566-2580 JJ denotes CD40-deficient
T1310 2581-2585 NN denotes mice
T1311 2586-2589 CC denotes and
T1312 2590-2597 VB denotes restore
T1313 2598-2612 NN denotes immunoglobulin
T1314 2613-2614 -LRB- denotes (
T1315 2614-2616 NN denotes Ig
T1316 2616-2617 -RRB- denotes )
T1317 2618-2623 NN denotes class
T1318 2624-2633 NN denotes switching
T1319 2633-2634 -COMMA- denotes ,
T1320 2635-2639 RB denotes most
T1321 2640-2646 RB denotes likely
T1322 2647-2654 IN denotes because
T1323 2655-2659 NN denotes LMP1
T1324 2660-2668 VB denotes recruits
T1325 2669-2676 JJ denotes similar
T1326 2677-2681 NN denotes TRAF
T1327 2682-2691 NN denotes molecules
T1328 2691-2692 -COMMA- denotes ,
T1329 2693-2698 NN denotes TRAFs
T1330 2699-2706 CD denotes 1/2/3/5
T1331 2707-2710 CC denotes and
T1332 2711-2716 NN denotes TRAF6
T1333 2716-2717 -COMMA- denotes ,
T1334 2718-2725 IN denotes through
T1335 2726-2729 DT denotes the
T1336 2730-2740 JJ denotes C-terminal
T1337 2741-2751 NN denotes activation
T1338 2752-2759 NN denotes regions
T1339 2760-2761 CD denotes 1
T1340 2762-2765 CC denotes and
T1341 2766-2767 CD denotes 2
T1342 2768-2775 NN denotes domains
T1343 2775-2776 -COMMA- denotes ,
T1344 2777-2789 RB denotes respectively
T1345 2791-2798 RB denotes However
T1346 2798-2799 -COMMA- denotes ,
T1347 2800-2804 NN denotes LMP1
T1348 2805-2807 VB denotes is
T1349 2808-2814 JJ denotes unable
T1350 2815-2817 TO denotes to
T1351 2818-2825 VB denotes restore
T1352 2826-2834 NN denotes affinity
T1353 2835-2845 NN denotes maturation
T1354 2846-2849 CC denotes and
T1355 2850-2852 NN denotes GC
T1356 2853-2862 NN denotes formation
T1357 2863-2864 -LRB- denotes [
T1358 2864-2866 CD denotes 23
T1359 2866-2867 -RRB- denotes ]
T1360 2869-2876 JJ denotes Several
T1361 2877-2880 NN denotes EBV
T1362 2881-2893 VB denotes transforming
T1363 2894-2902 NN denotes proteins
T1364 2903-2907 VB denotes have
T1365 2908-2912 VB denotes been
T1366 2913-2920 VB denotes studied
T1367 2921-2923 IN denotes in
T1368 2924-2934 JJ denotes transgenic
T1369 2935-2940 NN denotes mouse
T1370 2941-2947 NN denotes models
T1371 2947-2948 -COMMA- denotes ,
T1372 2949-2956 RB denotes however
T1373 2956-2957 -COMMA- denotes ,
T1374 2958-2962 RB denotes only
T1375 2963-2967 NN denotes LMP1
T1376 2968-2975 VB denotes induces
T1377 2976-2981 NN denotes tumor
T1378 2982-2993 NN denotes development
T1379 2994-2998 WRB denotes when
T1380 2999-3008 VB denotes expressed
T1381 3009-3014 IN denotes under
T1382 3015-3018 DT denotes the
T1383 3019-3026 NN denotes control
T1384 3027-3029 IN denotes of
T1385 3030-3033 DT denotes the
T1386 3034-3036 NN denotes Ig
T1387 3037-3042 JJ denotes heavy
T1388 3043-3048 NN denotes chain
T1389 3049-3057 NN denotes promoter
T1390 3058-3061 CC denotes and
T1391 3062-3070 NN denotes enhancer
T1392 3071-3072 -LRB- denotes [
T1393 3072-3077 CD denotes 24–26
T1394 3077-3078 -RRB- denotes ]
T1395 3080-3083 DT denotes The
T1396 3084-3088 NN denotes LMP1
T1397 3089-3099 JJ denotes transgenic
T1398 3100-3104 NN denotes mice
T1399 3105-3106 -LRB- denotes (
T1400 3106-3112 NN denotes IgLMP1
T1401 3112-3113 -RRB- denotes )
T1402 3114-3121 VB denotes express
T1403 3122-3126 NN denotes LMP1
T1404 3127-3129 IN denotes in
T1405 3130-3131 NN denotes B
T1406 3132-3143 NN denotes lymphocytes
T1407 3143-3144 -COMMA- denotes ,
T1408 3145-3148 CC denotes and
T1409 3149-3151 IN denotes in
T1410 3152-3156 NN denotes mice
T1411 3157-3162 JJ denotes older
T1412 3163-3167 IN denotes than
T1413 3168-3170 CD denotes 12
T1414 3171-3173 NN denotes mo
T1415 3173-3174 -COMMA- denotes ,
T1416 3175-3183 NN denotes lymphoma
T1417 3184-3192 VB denotes develops
T1418 3193-3197 IN denotes with
T1419 3198-3207 VB denotes increased
T1420 3208-3217 NN denotes incidence
T1421 3218-3219 -LRB- denotes (
T1422 3219-3221 CD denotes 40
T1423 3221-3222 NN denotes %
T1424 3222-3225 CD denotes –50
T1425 3225-3226 NN denotes %
T1426 3226-3227 -RRB- denotes )
T1427 3228-3236 VB denotes compared
T1428 3237-3239 TO denotes to
T1429 3240-3249 JJ denotes wild-type
T1430 3250-3257 NN denotes control
T1431 3258-3262 NN denotes mice
T1432 3263-3264 -LRB- denotes (
T1433 3264-3266 CD denotes 11
T1434 3266-3267 NN denotes %
T1435 3267-3268 -RRB- denotes )
T1436 3268-3269 -COMMA- denotes ,
T1437 3270-3280 VB denotes suggesting
T1438 3281-3285 IN denotes that
T1439 3286-3290 NN denotes LMP1
T1440 3291-3302 VB denotes contributes
T1441 3303-3305 TO denotes to
T1442 3306-3311 NN denotes tumor
T1443 3312-3323 NN denotes development
T1444 3324-3325 -LRB- denotes [
T1445 3325-3327 CD denotes 26
T1446 3327-3328 -RRB- denotes ]
T1447 3330-3333 DT denotes The
T1448 3334-3338 NN denotes LMP1
T1449 3339-3348 NN denotes lymphomas
T1450 3349-3353 VB denotes have
T1451 3354-3364 VB denotes rearranged
T1452 3365-3367 NN denotes Ig
T1453 3368-3373 NN denotes genes
T1454 3374-3377 CC denotes and
T1455 3378-3382 VB denotes have
T1456 3383-3392 VB denotes activated
T1457 3393-3396 NN denotes Akt
T1458 3396-3397 -COMMA- denotes ,
T1459 3398-3401 NN denotes JNK
T1460 3401-3402 -COMMA- denotes ,
T1461 3403-3406 NN denotes p38
T1462 3406-3407 -COMMA- denotes ,
T1463 3408-3411 CC denotes and
T1464 3412-3416 NN denotes NFκB
T1465 3416-3417 -COMMA- denotes ,
T1466 3418-3422 IN denotes with
T1467 3423-3431 JJ denotes specific
T1468 3432-3442 NN denotes activation
T1469 3443-3445 IN denotes of
T1470 3446-3449 DT denotes the
T1471 3450-3454 NN denotes NFκB
T1472 3455-3461 NN denotes family
T1473 3462-3468 NN denotes member
T1474 3469-3473 NN denotes cRel
T1475 3474-3475 -LRB- denotes [
T1476 3475-3477 CD denotes 27
T1477 3477-3478 -RRB- denotes ]
T1478 3480-3482 IN denotes In
T1479 3483-3487 DT denotes this
T1480 3488-3493 NN denotes study
T1481 3493-3494 -COMMA- denotes ,
T1482 3495-3498 DT denotes the
T1483 3499-3503 NN denotes LMP1
T1484 3504-3514 JJ denotes transgenic
T1485 3515-3526 NN denotes lymphocytes
T1486 3527-3530 CC denotes and
T1487 3531-3540 NN denotes lymphomas
T1488 3541-3545 VB denotes were
T1489 3546-3553 RB denotes further
T1490 3554-3567 VB denotes characterized
T1491 3568-3571 CC denotes and
T1492 3572-3577 PRP-DOLLAR- denotes their
T1493 3578-3584 NN denotes growth
T1494 3585-3595 NN denotes properties
T1495 3596-3598 FW denotes in
T1496 3599-3604 FW denotes vitro
T1497 3605-3609 VB denotes were
T1498 3610-3620 VB denotes determined
T1499 3622-3624 TO denotes To
T1500 3625-3631 VB denotes obtain
T1501 3632-3636 JJ denotes pure
T1502 3637-3648 NN denotes populations
T1503 3649-3651 IN denotes of
T1504 3652-3661 JJ denotes malignant
T1505 3662-3673 NN denotes lymphocytes
T1506 3674-3677 CC denotes and
T1507 3678-3680 TO denotes to
T1508 3681-3687 VB denotes enable
T1509 3688-3692 RB denotes more
T1510 3693-3701 JJ denotes detailed
T1511 3702-3713 JJ denotes biochemical
T1512 3714-3722 NN denotes analyses
T1513 3722-3723 -COMMA- denotes ,
T1514 3724-3732 NN denotes examples
T1515 3733-3735 IN denotes of
T1516 3736-3743 JJ denotes primary
T1517 3744-3753 NN denotes lymphomas
T1518 3754-3758 VB denotes were
T1519 3759-3769 VB denotes inoculated
T1520 3770-3773 CC denotes and
T1521 3774-3782 VB denotes passaged
T1522 3783-3785 IN denotes in
T1523 3786-3790 NN denotes SCID
T1524 3791-3795 NN denotes mice
T1525 3797-3810 RB denotes Interestingly
T1526 3810-3811 -COMMA- denotes ,
T1527 3812-3820 NN denotes lymphoma
T1528 3821-3832 NN denotes development
T1529 3833-3836 VB denotes was
T1530 3837-3847 JJ denotes restricted
T1531 3848-3850 TO denotes to
T1532 3851-3855 NN denotes B-1a
T1533 3856-3867 NN denotes lymphocytes
T1534 3867-3868 -COMMA- denotes ,
T1535 3869-3870 DT denotes a
T1536 3871-3888 JJ denotes self-replenishing
T1537 3889-3899 NN denotes population
T1538 3900-3902 IN denotes of
T1539 3903-3908 NN denotes cells
T1540 3909-3913 WDT denotes that
T1541 3914-3917 VB denotes are
T1542 3918-3923 JJ denotes prone
T1543 3924-3926 TO denotes to
T1544 3927-3937 NN denotes malignancy
T1545 3938-3939 -LRB- denotes [
T1546 3939-3944 CD denotes 28,29
T1547 3944-3945 -RRB- denotes ]
T1548 3947-3951 NN denotes LMP1
T1549 3952-3962 JJ denotes transgenic
T1550 3963-3974 NN denotes lymphocytes
T1551 3975-3978 VB denotes had
T1552 3979-3988 VB denotes increased
T1553 3989-3998 NN denotes viability
T1554 3999-4001 FW denotes in
T1555 4002-4007 FW denotes vitro
T1556 4008-4011 CC denotes and
T1557 4012-4021 NN denotes viability
T1558 4022-4025 VB denotes was
T1559 4026-4035 VB denotes increased
T1560 4036-4038 IN denotes by
T1561 4039-4042 DT denotes the
T1562 4043-4051 NN denotes addition
T1563 4052-4054 IN denotes of
T1564 4055-4058 NN denotes IL4
T1565 4060-4062 IN denotes In
T1566 4063-4071 NN denotes contrast
T1567 4071-4072 -COMMA- denotes ,
T1568 4073-4077 CC denotes both
T1569 4078-4091 JJ denotes LMP1-positive
T1570 4092-4095 CC denotes and
T1571 4096-4105 JJ denotes -negative
T1572 4106-4114 NN denotes lymphoma
T1573 4115-4120 NN denotes cells
T1574 4121-4125 VB denotes were
T1575 4126-4137 JJ denotes independent
T1576 4138-4140 IN denotes of
T1577 4141-4144 NN denotes IL4
T1578 4145-4159 NN denotes co-stimulation
T1579 4160-4163 IN denotes for
T1580 4164-4172 NN denotes survival
T1581 4173-4176 CC denotes and
T1582 4177-4190 NN denotes proliferation
T1583 4191-4193 FW denotes in
T1584 4194-4199 FW denotes vitro
T1585 4200-4204 IN denotes with
T1586 4205-4206 DT denotes a
T1587 4207-4215 JJ denotes complete
T1588 4216-4223 NN denotes absence
T1589 4224-4226 IN denotes of
T1590 4227-4236 VB denotes activated
T1591 4237-4242 NN denotes Stat6
T1592 4242-4243 -COMMA- denotes ,
T1593 4244-4247 DT denotes the
T1594 4248-4251 NN denotes IL4
T1595 4252-4258 NN denotes target
T1596 4260-4263 DT denotes The
T1597 4264-4273 NN denotes lymphomas
T1598 4274-4278 VB denotes were
T1599 4279-4283 RB denotes also
T1600 4284-4297 VB denotes distinguished
T1601 4298-4300 IN denotes by
T1602 4301-4313 JJ denotes constitutive
T1603 4314-4324 NN denotes activation
T1604 4325-4327 IN denotes of
T1605 4328-4333 NN denotes Stat3
T1606 4334-4337 CC denotes and
T1607 4338-4350 NN denotes deregulation
T1608 4351-4353 IN denotes of
T1609 4354-4357 DT denotes the
T1610 4358-4360 NN denotes Rb
T1611 4361-4365 NN denotes cell
T1612 4366-4371 NN denotes cycle
T1613 4372-4379 NN denotes pathway
T1614 4381-4391 NN denotes Inhibition
T1615 4392-4394 IN denotes of
T1616 4395-4398 DT denotes the
T1617 4399-4407 NN denotes PI3K/Akt
T1618 4407-4408 -COMMA- denotes ,
T1619 4409-4413 NN denotes NFκB
T1620 4413-4414 -COMMA- denotes ,
T1621 4415-4418 CC denotes and
T1622 4419-4424 NN denotes Stat3
T1623 4425-4434 NN denotes signaling
T1624 4435-4443 NN denotes pathways
T1625 4444-4451 VB denotes blocked
T1626 4452-4455 DT denotes the
T1627 4456-4464 VB denotes enhanced
T1628 4465-4471 NN denotes growth
T1629 4472-4474 IN denotes of
T1630 4475-4479 CC denotes both
T1631 4480-4484 NN denotes LMP1
T1632 4485-4495 JJ denotes transgenic
T1633 4496-4499 CC denotes and
T1634 4500-4509 JJ denotes malignant
T1635 4510-4521 NN denotes lymphocytes
T1636 4521-4522 -COMMA- denotes ,
T1637 4523-4533 VB denotes suggesting
T1638 4534-4538 IN denotes that
T1639 4539-4544 DT denotes these
T1640 4545-4553 NN denotes pathways
T1641 4554-4557 VB denotes are
T1642 4558-4566 VB denotes required
T1643 4567-4570 IN denotes for
T1644 4571-4576 PRP-DOLLAR- denotes their
T1645 4577-4583 NN denotes growth
T1646 4584-4587 CC denotes and
T1647 4588-4596 NN denotes survival
T1648 4598-4603 DT denotes These
T1649 4604-4610 VB denotes appear
T1650 4611-4613 TO denotes to
T1651 4614-4616 VB denotes be
T1652 4617-4620 DT denotes the
T1653 4621-4625 JJ denotes same
T1654 4626-4633 NN denotes targets
T1655 4634-4638 WDT denotes that
T1656 4639-4642 VB denotes are
T1657 4643-4654 VB denotes deregulated
T1658 4655-4657 IN denotes in
T1659 4658-4667 JJ denotes wild-type
T1660 4668-4672 NN denotes B-1a
T1661 4673-4682 NN denotes lymphomas
T1662 4683-4687 WDT denotes that
T1663 4688-4693 VB denotes arise
T1664 4694-4707 RB denotes spontaneously
T1665 4708-4715 IN denotes through
T1666 4716-4719 NN denotes age
T1667 4720-4734 NN denotes predisposition
T1668 4736-4740 DT denotes This
T1669 4741-4746 NN denotes study
T1670 4747-4754 VB denotes reveals
T1671 4755-4759 IN denotes that
T1672 4760-4764 NN denotes LMP1
T1673 4765-4773 VB denotes promotes
T1674 4774-4784 NN denotes malignancy
T1675 4785-4787 IN denotes in
T1676 4788-4793 NN denotes cells
T1677 4794-4798 IN denotes with
T1678 4799-4802 DT denotes the
T1679 4803-4811 JJ denotes inherent
T1680 4812-4819 NN denotes ability
T1681 4820-4822 TO denotes to
T1682 4823-4834 VB denotes proliferate
T1683 4835-4838 CC denotes and
T1684 4839-4843 IN denotes that
T1685 4844-4847 DT denotes the
T1686 4848-4851 NN denotes Akt
T1687 4851-4852 -COMMA- denotes ,
T1688 4853-4857 NN denotes NFκB
T1689 4857-4858 -COMMA- denotes ,
T1690 4859-4862 CC denotes and
T1691 4863-4868 NN denotes Stat3
T1692 4869-4878 NN denotes signaling
T1693 4879-4887 NN denotes pathways
T1694 4888-4891 VB denotes are
T1695 4892-4900 VB denotes required
T1696 4901-4904 IN denotes for
T1697 4905-4908 PRP-DOLLAR- denotes its
T1698 4909-4915 NN denotes growth
T1699 4916-4927 JJ denotes stimulatory
T1700 4928-4935 NN denotes effects
R510 T881 T880 arg1Of virus,Epstein-Barr
R511 T881 T882 arg1Of virus,(
R512 T881 T885 arg1Of virus,is
R513 T883 T882 arg2Of EBV,(
R514 T884 T882 arg3Of ),(
R515 T888 T885 arg2Of γ-herpesvirus,is
R516 T888 T886 arg1Of γ-herpesvirus,a
R517 T888 T887 arg1Of γ-herpesvirus,ubiquitous
R518 T888 T889 arg1Of γ-herpesvirus,that
R519 T888 T890 arg1Of γ-herpesvirus,infects
R520 T890 T893 arg1Of infects,at
R521 T891 T890 arg2Of humans,infects
R522 T893 T892 arg1Of at,predominantly
R523 T896 T893 arg2Of age,at
R524 T896 T894 arg1Of age,an
R525 T896 T895 arg1Of age,early
R526 T896 T897 arg1Of age,with
R527 T898 T899 arg1Of greater,than
R528 T900 T899 arg2Of 90,than
R529 T901 T897 arg2Of %,with
R530 T901 T898 arg1Of %,greater
R531 T901 T902 arg1Of %,of
R532 T905 T902 arg2Of population,of
R533 T905 T903 arg1Of population,the
R534 T905 T904 arg1Of population,adult
R535 T905 T906 arg2Of population,infected
R536 T906 T907 arg1Of infected,with
R537 T908 T907 arg2Of EBV,with
R538 T908 T909 arg1Of EBV,[
R539 T910 T909 arg2Of 1,[
R540 T911 T909 arg3Of ],[
R541 T912 T913 arg1Of EBV,is
R542 T912 T914 arg2Of EBV,linked
R543 T914 T913 arg2Of linked,is
R544 T914 T915 arg1Of linked,to
R545 T917 T915 arg2Of development,to
R546 T917 T916 arg1Of development,the
R547 T917 T918 arg1Of development,of
R548 T921 T920 arg1Of lymphocyte,B
R549 T921 T922 arg1Of lymphocyte,and
R550 T922 T919 arg1Of and,both
R551 T924 T922 arg2Of cell,and
R552 T924 T923 arg1Of cell,epithelial
R553 T925 T918 arg2Of malignancies,of
R554 T925 T921 arg1Of malignancies,lymphocyte
R555 T925 T924 arg1Of malignancies,cell
R556 T925 T926 arg1Of malignancies,","
R557 T925 T927 arg1Of malignancies,including
R558 T929 T928 arg1Of lymphoma,Burkitt
R559 T929 T930 arg1Of lymphoma,","
R560 T930 T937 arg1Of ",",and
R561 T932 T930 arg2Of disease,","
R562 T932 T931 arg1Of disease,Hodgkin
R563 T932 T933 arg1Of disease,(
R564 T934 T933 arg2Of HD,(
R565 T935 T933 arg3Of ),(
R566 T937 T936 arg1Of and,","
R567 T937 T944 arg1Of and,and
R568 T939 T937 arg2Of carcinoma,and
R569 T939 T938 arg1Of carcinoma,nasopharyngeal
R570 T939 T940 arg1Of carcinoma,(
R571 T941 T940 arg2Of NPC,(
R572 T942 T940 arg3Of ),(
R573 T944 T927 arg2Of and,including
R574 T944 T943 arg1Of and,","
R575 T945 T944 arg2Of cancers,and
R576 T945 T946 arg2Of cancers,linked
R577 T946 T947 arg1Of linked,to
R578 T948 T947 arg2Of immunosuppression,to
R579 T948 T949 arg1Of immunosuppression,","
R580 T948 T950 arg1Of immunosuppression,including
R581 T951 T952 arg1Of post-transplant,lymphoma
R582 T951 T953 arg1Of post-transplant,and
R583 T954 T953 arg2Of AIDS-associated,and
R584 T955 T950 arg2Of lymphomas,including
R585 T955 T951 arg1Of lymphomas,post-transplant
R586 T955 T954 arg1Of lymphomas,AIDS-associated
R587 T955 T956 arg1Of lymphomas,[
R588 T957 T956 arg2Of "2,3",[
R589 T958 T956 arg3Of ],[
R590 T960 T959 arg1Of vitro,In
R591 T961 T960 arg1Of infection,vitro
R592 T961 T962 arg1Of infection,of
R593 T961 T965 arg1Of infection,with
R594 T961 T967 arg1Of infection,induces
R595 T964 T962 arg2Of lymphocytes,of
R596 T964 T963 arg1Of lymphocytes,B
R597 T966 T965 arg2Of EBV,with
R598 T967 T972 arg1Of induces,and
R599 T970 T967 arg2Of transformation,induces
R600 T970 T968 arg1Of transformation,permanent
R601 T970 T969 arg1Of transformation,growth
R602 T972 T971 arg1Of and,","
R603 T974 T973 arg1Of ability,this
R604 T974 T975 modOf ability,to
R605 T974 T981 arg1Of ability,contributes
R606 T976 T975 arg1Of affect,to
R607 T979 T976 arg2Of regulation,affect
R608 T979 T977 arg1Of regulation,cell
R609 T979 T978 arg1Of regulation,growth
R610 T981 T972 arg2Of contributes,and
R611 T981 T980 arg1Of contributes,likely
R612 T981 T982 arg1Of contributes,to
R613 T984 T982 arg2Of development,to
R614 T984 T983 arg1Of development,the
R615 T984 T985 arg1Of development,of
R616 T986 T985 arg2Of cancer,of
R617 T987 T988 arg1Of Many,of
R618 T987 T996 arg1Of Many,","
R619 T987 T997 arg1Of Many,including
R620 T987 T1007 arg1Of Many,have
R621 T987 T1015 arg1Of Many,are
R622 T987 T1016 arg2Of Many,required
R623 T991 T988 arg2Of proteins,of
R624 T991 T989 arg1Of proteins,the
R625 T991 T990 arg1Of proteins,viral
R626 T991 T992 arg2Of proteins,expressed
R627 T992 T993 arg1Of expressed,in
R628 T995 T993 arg2Of cells,in
R629 T995 T994 arg2Of cells,transformed
R630 T1001 T999 arg1Of antigens,EBV
R631 T1001 T1000 arg1Of antigens,nuclear
R632 T1001 T1002 arg1Of antigens,and
R633 T1002 T997 arg2Of and,including
R634 T1002 T998 arg1Of and,the
R635 T1005 T1002 arg2Of proteins,and
R636 T1005 T1003 arg1Of proteins,latent
R637 T1005 T1004 arg1Of proteins,membrane
R638 T1007 T1010 arg1Of have,on
R639 T1007 T1014 arg1Of have,and
R640 T1009 T1007 arg2Of effects,have
R641 T1009 T1008 arg1Of effects,profound
R642 T1013 T1010 arg2Of regulation,on
R643 T1013 T1011 arg1Of regulation,cell
R644 T1013 T1012 arg1Of regulation,growth
R645 T1014 T1006 arg1Of and,","
R646 T1016 T1014 arg2Of required,and
R647 T1016 T1015 arg2Of required,are
R648 T1016 T1017 arg1Of required,for
R649 T1020 T1018 arg1Of infection,EBV
R650 T1020 T1019 arg1Of infection,latent
R651 T1020 T1021 arg1Of infection,and
R652 T1021 T1017 arg2Of and,for
R653 T1024 T1021 arg2Of transformation,and
R654 T1024 T1022 arg1Of transformation,B
R655 T1024 T1023 arg1Of transformation,cell
R656 T1024 T1025 arg1Of transformation,[
R657 T1026 T1025 arg2Of 1,[
R658 T1027 T1025 arg3Of ],[
R659 T1030 T1028 arg1Of protein,Latent
R660 T1030 T1029 arg1Of protein,membrane
R661 T1030 T1031 arg1Of protein,1
R662 T1030 T1032 arg1Of protein,(
R663 T1030 T1035 arg1Of protein,is
R664 T1030 T1036 arg2Of protein,considered
R665 T1033 T1032 arg2Of LMP1,(
R666 T1034 T1032 arg3Of ),(
R667 T1036 T1035 arg2Of considered,is
R668 T1036 T1042 arg1Of considered,","
R669 T1036 T1043 arg1Of considered,as
R670 T1039 T1036 arg3Of oncoprotein,considered
R671 T1039 T1037 arg1Of oncoprotein,the
R672 T1039 T1038 arg1Of oncoprotein,major
R673 T1039 T1040 arg1Of oncoprotein,of
R674 T1041 T1040 arg2Of EBV,of
R675 T1044 T1045 arg1Of it,transforms
R676 T1044 T1054 arg1Of it,is
R677 T1044 T1055 arg2Of it,expressed
R678 T1045 T1050 arg1Of transforms,in
R679 T1045 T1053 arg1Of transforms,and
R680 T1047 T1045 arg2Of fibroblasts,transforms
R681 T1047 T1046 arg1Of fibroblasts,rodent
R682 T1047 T1048 arg1Of fibroblasts,to
R683 T1049 T1048 arg2Of tumorigenicity,to
R684 T1052 T1050 arg2Of mice,in
R685 T1052 T1051 arg1Of mice,nude
R686 T1053 T1043 arg2Of and,as
R687 T1055 T1053 arg2Of expressed,and
R688 T1055 T1054 arg2Of expressed,is
R689 T1055 T1056 arg1Of expressed,in
R690 T1057 T1058 arg1Of HD,","
R691 T1058 T1061 arg1Of ",",and
R692 T1059 T1058 arg2Of NPC,","
R693 T1061 T1056 arg2Of and,in
R694 T1061 T1060 arg1Of and,","
R695 T1063 T1061 arg2Of tumors,and
R696 T1063 T1062 arg1Of tumors,immunosuppression-associated
R697 T1063 T1064 arg1Of tumors,[
R698 T1065 T1064 arg2Of 4–8,[
R699 T1066 T1064 arg3Of ],[
R700 T1069 T1067 arg2Of lymphocytes,In
R701 T1069 T1068 arg1Of lymphocytes,B
R702 T1071 T1072 arg1Of LMP1,mimics
R703 T1072 T1076 arg1Of mimics,and
R704 T1074 T1072 arg2Of signaling,mimics
R705 T1074 T1073 arg1Of signaling,CD40
R706 T1076 T1067 arg1Of and,In
R707 T1076 T1070 arg1Of and,","
R708 T1076 T1075 arg1Of and,","
R709 T1078 T1079 arg1Of LMP1,and
R710 T1079 T1077 arg1Of and,both
R711 T1079 T1081 arg1Of and,are
R712 T1079 T1082 arg1Of and,essential
R713 T1080 T1079 arg2Of CD40,and
R714 T1081 T1076 arg2Of are,and
R715 T1082 T1081 arg2Of essential,are
R716 T1082 T1083 arg1Of essential,for
R717 T1087 T1083 arg2Of transformation,for
R718 T1087 T1084 arg1Of transformation,EBV-mediated
R719 T1087 T1085 arg1Of transformation,B
R720 T1087 T1086 arg1Of transformation,cell
R721 T1087 T1088 arg1Of transformation,[
R722 T1089 T1088 arg2Of 9–11,[
R723 T1090 T1088 arg3Of ],[
R724 T1092 T1093 arg1Of CD40,interacts
R725 T1093 T1091 arg2Of interacts,While
R726 T1093 T1094 arg1Of interacts,with
R727 T1096 T1094 arg2Of ligand,with
R728 T1096 T1095 arg1Of ligand,CD40
R729 T1096 T1097 arg2Of ligand,expressed
R730 T1097 T1098 arg1Of expressed,on
R731 T1097 T1102 modOf expressed,to
R732 T1101 T1098 arg2Of cells,on
R733 T1101 T1099 arg2Of cells,activated
R734 T1101 T1100 arg1Of cells,T
R735 T1103 T1102 arg1Of induce,to
R736 T1106 T1107 arg1Of activation,and
R737 T1107 T1103 arg2Of and,induce
R738 T1107 T1104 arg1Of and,B
R739 T1107 T1105 arg1Of and,cell
R740 T1108 T1107 arg2Of differentiation,and
R741 T1110 T1111 arg1Of LMP1,acts
R742 T1111 T1091 arg1Of acts,While
R743 T1111 T1109 arg1Of acts,","
R744 T1111 T1112 arg1Of acts,as
R745 T1111 T1116 arg1Of acts,through
R746 T1115 T1112 arg2Of signal,as
R747 T1115 T1113 arg1Of signal,a
R748 T1115 T1114 arg1Of signal,constitutive
R749 T1118 T1116 arg2Of oligomerization,through
R750 T1118 T1117 arg1Of oligomerization,ligand-independent
R751 T1119 T1120 arg1Of LMP1,and
R752 T1120 T1122 arg1Of and,interact
R753 T1121 T1120 arg2Of CD40,and
R754 T1122 T1123 arg1Of interact,with
R755 T1130 T1125 arg1Of factors,same
R756 T1130 T1126 arg1Of factors,tumor
R757 T1130 T1127 arg1Of factors,necrosis
R758 T1130 T1128 arg1Of factors,factor
R759 T1130 T1129 arg2Of factors,receptor–associated
R760 T1130 T1131 arg1Of factors,(
R761 T1130 T1134 arg1Of factors,leading
R762 T1130 T1148 arg1Of factors,and
R763 T1132 T1131 arg2Of TRAFs,(
R764 T1133 T1131 arg3Of ),(
R765 T1134 T1135 arg1Of leading,to
R766 T1136 T1135 arg2Of activation,to
R767 T1136 T1137 arg1Of activation,of
R768 T1138 T1139 arg1Of NFκB,","
R769 T1139 T1137 arg2Of ",",of
R770 T1143 T1139 arg2Of kinase,","
R771 T1143 T1140 arg1Of kinase,c-Jun
R772 T1143 T1141 arg1Of kinase,N
R773 T1143 T1142 arg1Of kinase,terminal
R774 T1143 T1144 arg1Of kinase,(
R775 T1145 T1144 arg2Of JNK,(
R776 T1146 T1144 arg3Of ),(
R777 T1148 T1123 arg2Of and,with
R778 T1148 T1124 arg1Of and,the
R779 T1148 T1147 arg1Of and,","
R780 T1152 T1148 arg2Of pathways,and
R781 T1152 T1149 arg1Of pathways,p38
R782 T1152 T1150 arg1Of pathways,MAPK
R783 T1152 T1151 arg1Of pathways,signaling
R784 T1152 T1153 arg1Of pathways,[
R785 T1154 T1153 arg2Of 12–16,[
R786 T1155 T1153 arg3Of ],[
R787 T1156 T1157 arg1Of Activation,of
R788 T1156 T1159 arg1Of Activation,is
R789 T1156 T1160 arg2Of Activation,required
R790 T1158 T1157 arg2Of NFκB,of
R791 T1160 T1159 arg2Of required,is
R792 T1160 T1161 arg1Of required,for
R793 T1160 T1166 arg1Of required,and
R794 T1165 T1161 arg2Of transformation,for
R795 T1165 T1162 arg1Of transformation,EBV-induced
R796 T1165 T1163 arg1Of transformation,B
R797 T1165 T1164 arg1Of transformation,cell
R798 T1168 T1167 arg1Of inhibition,its
R799 T1168 T1170 arg1Of inhibition,results
R800 T1170 T1166 arg2Of results,and
R801 T1170 T1169 arg1Of results,rapidly
R802 T1170 T1171 arg1Of results,in
R803 T1170 T1174 arg1Of results,[
R804 T1173 T1171 arg2Of death,in
R805 T1173 T1172 arg1Of death,cell
R806 T1175 T1174 arg2Of "17,18",[
R807 T1176 T1174 arg3Of ],[
R808 T1178 T1177 arg1Of studies,Recent
R809 T1178 T1179 arg1Of studies,indicate
R810 T1181 T1183 arg1Of LMP1,activates
R811 T1183 T1180 arg1Of activates,that
R812 T1183 T1182 arg1Of activates,also
R813 T1183 T1192 arg1Of activates,and
R814 T1186 T1184 arg1Of kinase,phosphatidylinositol
R815 T1186 T1185 arg1Of kinase,3
R816 T1186 T1187 arg1Of kinase,(
R817 T1188 T1187 arg2Of PI3K,(
R818 T1189 T1187 arg3Of ),(
R819 T1191 T1183 arg2Of signaling,activates
R820 T1191 T1186 arg1Of signaling,kinase
R821 T1191 T1190 arg1Of signaling,/Akt
R822 T1192 T1179 arg2Of and,indicate
R823 T1193 T1192 arg2Of that,and
R824 T1195 T1194 arg1Of activation,this
R825 T1195 T1196 arg1Of activation,is
R826 T1195 T1197 arg2Of activation,required
R827 T1197 T1193 arg2Of required,that
R828 T1197 T1196 arg2Of required,is
R829 T1197 T1198 arg1Of required,for
R830 T1200 T1198 arg2Of transformation,for
R831 T1200 T1199 arg1Of transformation,LMP1-mediated
R832 T1200 T1201 arg1Of transformation,of
R833 T1203 T1201 arg2Of fibroblasts,of
R834 T1203 T1202 arg1Of fibroblasts,rodent
R835 T1203 T1204 arg1Of fibroblasts,[
R836 T1205 T1204 arg2Of "5,19",[
R837 T1206 T1204 arg3Of ],[
R838 T1208 T1207 arg1Of vitro,In
R839 T1212 T1210 arg1Of cells,primary
R840 T1212 T1211 arg1Of cells,B
R841 T1212 T1213 arg1Of cells,can
R842 T1212 T1214 arg1Of cells,be
R843 T1212 T1215 arg2Of cells,maintained
R844 T1215 T1208 arg1Of maintained,vitro
R845 T1215 T1209 arg1Of maintained,","
R846 T1215 T1213 arg2Of maintained,can
R847 T1215 T1214 arg2Of maintained,be
R848 T1215 T1219 arg1Of maintained,in
R849 T1218 T1215 arg1Of ligation,maintained
R850 T1218 T1216 arg2Of ligation,by
R851 T1218 T1217 arg1Of ligation,CD40
R852 T1220 T1219 arg2Of combination,in
R853 T1220 T1221 arg1Of combination,with
R854 T1223 T1221 arg2Of treatment,with
R855 T1223 T1222 arg1Of treatment,IL4
R856 T1224 T1229 modOf In,is
R857 T1228 T1227 arg1Of signaling,CD40
R858 T1228 T1229 arg1Of signaling,is
R859 T1228 T1230 arg1Of signaling,necessary
R860 T1229 T1225 arg1Of is,vivo
R861 T1229 T1226 arg1Of is,","
R862 T1230 T1229 arg2Of necessary,is
R863 T1230 T1231 arg1Of necessary,for
R864 T1233 T1231 arg2Of center,for
R865 T1233 T1232 arg1Of center,germinal
R866 T1233 T1234 arg1Of center,(
R867 T1235 T1234 arg2Of GC,(
R868 T1236 T1234 arg3Of ),(
R869 T1237 T1238 arg1Of formation,such
R870 T1238 T1224 arg1Of such,In
R871 T1240 T1241 arg1Of mice,deficient
R872 T1240 T1246 arg1Of mice,are
R873 T1240 T1247 arg1Of mice,unable
R874 T1240 T1249 arg1Of mice,form
R875 T1241 T1242 arg1Of deficient,for
R876 T1243 T1244 arg1Of CD40,or
R877 T1244 T1242 arg2Of or,for
R878 T1245 T1244 arg2Of CD40L,or
R879 T1246 T1238 arg2Of are,such
R880 T1246 T1239 arg1Of are,that
R881 T1247 T1246 arg2Of unable,are
R882 T1249 T1247 arg2Of form,unable
R883 T1249 T1248 arg1Of form,to
R884 T1249 T1251 arg1Of form,in
R885 T1250 T1249 arg2Of GCs,form
R886 T1252 T1251 arg2Of response,in
R887 T1252 T1253 arg1Of response,to
R888 T1256 T1253 arg2Of antigens,to
R889 T1256 T1254 arg1Of antigens,T
R890 T1256 T1255 arg1Of antigens,cell–dependent
R891 T1256 T1257 arg1Of antigens,[
R892 T1258 T1257 arg2Of "20,21",[
R893 T1259 T1257 arg3Of ],[
R894 T1263 T1264 arg1Of proximal,and
R895 T1265 T1264 arg2Of distal,and
R896 T1267 T1260 arg1Of regions,Both
R897 T1267 T1261 arg1Of regions,the
R898 T1267 T1262 arg1Of regions,membrane
R899 T1267 T1263 arg1Of regions,proximal
R900 T1267 T1265 arg1Of regions,distal
R901 T1267 T1266 arg1Of regions,cytoplasmic
R902 T1267 T1268 arg1Of regions,of
R903 T1267 T1270 arg1Of regions,that
R904 T1267 T1271 arg1Of regions,bind
R905 T1267 T1278 arg1Of regions,are
R906 T1267 T1279 arg1Of regions,necessary
R907 T1269 T1268 arg2Of CD40,of
R908 T1271 T1275 arg1Of bind,","
R909 T1271 T1276 arg1Of bind,respectively
R910 T1272 T1273 arg1Of TRAF6,and
R911 T1273 T1271 arg2Of and,bind
R912 T1274 T1273 arg2Of TRAFs2/3/5,and
R913 T1278 T1277 arg1Of are,","
R914 T1278 T1284 arg1Of are,but
R915 T1279 T1278 arg2Of necessary,are
R916 T1279 T1280 arg1Of necessary,for
R917 T1282 T1280 arg2Of formation,for
R918 T1282 T1281 arg1Of formation,GC
R919 T1284 T1283 arg1Of but,","
R920 T1286 T1285 arg1Of region,either
R921 T1286 T1287 arg1Of region,is
R922 T1286 T1288 arg1Of region,sufficient
R923 T1287 T1284 arg2Of is,but
R924 T1288 T1287 arg2Of sufficient,is
R925 T1290 T1295 arg1Of induce,and
R926 T1294 T1290 arg2Of differentiation,induce
R927 T1294 T1291 arg1Of differentiation,extrafollicular
R928 T1294 T1292 arg1Of differentiation,B
R929 T1294 T1293 arg1Of differentiation,cell
R930 T1295 T1288 arg2Of and,sufficient
R931 T1295 T1289 arg1Of and,to
R932 T1296 T1295 arg2Of restore,and
R933 T1296 T1301 arg1Of restore,[
R934 T1300 T1296 arg2Of production,restore
R935 T1300 T1297 arg1Of production,low
R936 T1300 T1298 arg1Of production,affinity
R937 T1300 T1299 arg1Of production,antibody
R938 T1302 T1301 arg2Of 22,[
R939 T1303 T1301 arg3Of ],[
R940 T1306 T1307 arg1Of LMP1,can
R941 T1306 T1308 arg1Of LMP1,rescue
R942 T1306 T1312 arg1Of LMP1,restore
R943 T1308 T1311 arg1Of rescue,and
R944 T1310 T1308 arg2Of mice,rescue
R945 T1310 T1309 arg1Of mice,CD40-deficient
R946 T1311 T1304 arg1Of and,Functionally
R947 T1311 T1305 arg1Of and,","
R948 T1311 T1307 arg2Of and,can
R949 T1311 T1319 arg1Of and,","
R950 T1311 T1321 arg1Of and,likely
R951 T1311 T1322 arg1Of and,because
R952 T1311 T1343 arg1Of and,","
R953 T1311 T1344 arg1Of and,respectively
R954 T1312 T1311 arg2Of restore,and
R955 T1315 T1314 arg2Of Ig,(
R956 T1316 T1314 arg3Of ),(
R957 T1318 T1312 arg2Of switching,restore
R958 T1318 T1313 arg1Of switching,immunoglobulin
R959 T1318 T1314 arg1Of switching,(
R960 T1318 T1317 arg1Of switching,class
R961 T1321 T1320 arg1Of likely,most
R962 T1323 T1324 arg1Of LMP1,recruits
R963 T1324 T1322 arg2Of recruits,because
R964 T1324 T1333 arg1Of recruits,","
R965 T1324 T1334 arg1Of recruits,through
R966 T1327 T1324 arg2Of molecules,recruits
R967 T1327 T1325 arg1Of molecules,similar
R968 T1327 T1326 arg1Of molecules,TRAF
R969 T1327 T1328 arg1Of molecules,","
R970 T1330 T1331 arg1Of 1/2/3/5,and
R971 T1331 T1328 arg2Of and,","
R972 T1331 T1329 arg1Of and,TRAFs
R973 T1332 T1331 arg2Of TRAF6,and
R974 T1338 T1336 arg1Of regions,C-terminal
R975 T1338 T1337 arg1Of regions,activation
R976 T1339 T1340 arg1Of 1,and
R977 T1341 T1340 arg2Of 2,and
R978 T1342 T1334 arg2Of domains,through
R979 T1342 T1335 arg1Of domains,the
R980 T1342 T1338 arg1Of domains,regions
R981 T1342 T1339 arg1Of domains,1
R982 T1342 T1341 arg1Of domains,2
R983 T1347 T1348 arg1Of LMP1,is
R984 T1347 T1349 arg1Of LMP1,unable
R985 T1347 T1351 arg1Of LMP1,restore
R986 T1348 T1345 arg1Of is,However
R987 T1348 T1346 arg1Of is,","
R988 T1348 T1357 arg1Of is,[
R989 T1349 T1348 arg2Of unable,is
R990 T1351 T1349 arg2Of restore,unable
R991 T1351 T1350 arg1Of restore,to
R992 T1353 T1352 arg1Of maturation,affinity
R993 T1353 T1354 arg1Of maturation,and
R994 T1354 T1351 arg2Of and,restore
R995 T1356 T1354 arg2Of formation,and
R996 T1356 T1355 arg1Of formation,GC
R997 T1358 T1357 arg2Of 23,[
R998 T1359 T1357 arg3Of ],[
R999 T1363 T1360 arg1Of proteins,Several
R1000 T1363 T1361 arg1Of proteins,EBV
R1001 T1363 T1362 arg1Of proteins,transforming
R1002 T1363 T1364 arg1Of proteins,have
R1003 T1363 T1365 arg1Of proteins,been
R1004 T1363 T1366 arg2Of proteins,studied
R1005 T1366 T1364 arg2Of studied,have
R1006 T1366 T1365 arg2Of studied,been
R1007 T1366 T1367 arg1Of studied,in
R1008 T1366 T1371 arg1Of studied,","
R1009 T1370 T1367 arg2Of models,in
R1010 T1370 T1368 arg1Of models,transgenic
R1011 T1370 T1369 arg1Of models,mouse
R1012 T1375 T1374 arg1Of LMP1,only
R1013 T1375 T1376 arg1Of LMP1,induces
R1014 T1376 T1371 arg2Of induces,","
R1015 T1376 T1372 arg1Of induces,however
R1016 T1376 T1373 arg1Of induces,","
R1017 T1376 T1379 arg1Of induces,when
R1018 T1378 T1376 arg2Of development,induces
R1019 T1378 T1377 arg1Of development,tumor
R1020 T1380 T1379 arg2Of expressed,when
R1021 T1380 T1381 arg1Of expressed,under
R1022 T1383 T1382 arg1Of control,the
R1023 T1383 T1384 arg1Of control,of
R1024 T1383 T1390 arg1Of control,and
R1025 T1389 T1384 arg2Of promoter,of
R1026 T1389 T1385 arg1Of promoter,the
R1027 T1389 T1386 arg1Of promoter,Ig
R1028 T1389 T1387 arg1Of promoter,heavy
R1029 T1389 T1388 arg1Of promoter,chain
R1030 T1390 T1381 arg2Of and,under
R1031 T1391 T1390 arg2Of enhancer,and
R1032 T1391 T1392 arg1Of enhancer,[
R1033 T1393 T1392 arg2Of 24–26,[
R1034 T1394 T1392 arg3Of ],[
R1035 T1398 T1395 arg1Of mice,The
R1036 T1398 T1396 arg1Of mice,LMP1
R1037 T1398 T1397 arg1Of mice,transgenic
R1038 T1398 T1399 arg1Of mice,(
R1039 T1398 T1402 arg1Of mice,express
R1040 T1400 T1399 arg2Of IgLMP1,(
R1041 T1401 T1399 arg3Of ),(
R1042 T1402 T1404 arg1Of express,in
R1043 T1402 T1408 arg1Of express,and
R1044 T1403 T1402 arg2Of LMP1,express
R1045 T1406 T1404 arg2Of lymphocytes,in
R1046 T1406 T1405 arg1Of lymphocytes,B
R1047 T1408 T1407 arg1Of and,","
R1048 T1410 T1409 arg2Of mice,in
R1049 T1410 T1411 arg1Of mice,older
R1050 T1411 T1412 arg1Of older,than
R1051 T1414 T1412 arg2Of mo,than
R1052 T1414 T1413 arg1Of mo,12
R1053 T1416 T1417 arg1Of lymphoma,develops
R1054 T1417 T1408 arg2Of develops,and
R1055 T1417 T1409 arg1Of develops,in
R1056 T1417 T1415 arg1Of develops,","
R1057 T1417 T1418 arg1Of develops,with
R1058 T1417 T1427 arg1Of develops,compared
R1059 T1417 T1436 arg1Of develops,","
R1060 T1417 T1437 modOf develops,suggesting
R1061 T1420 T1418 arg2Of incidence,with
R1062 T1420 T1419 arg2Of incidence,increased
R1063 T1420 T1421 arg1Of incidence,(
R1064 T1425 T1421 arg2Of %,(
R1065 T1425 T1422 arg1Of %,40
R1066 T1425 T1423 arg1Of %,%
R1067 T1425 T1424 arg1Of %,–50
R1068 T1426 T1421 arg3Of ),(
R1069 T1428 T1427 arg2Of to,compared
R1070 T1431 T1428 arg2Of mice,to
R1071 T1431 T1429 arg1Of mice,wild-type
R1072 T1431 T1430 arg1Of mice,control
R1073 T1431 T1432 arg1Of mice,(
R1074 T1434 T1432 arg2Of %,(
R1075 T1434 T1433 arg1Of %,11
R1076 T1435 T1432 arg3Of ),(
R1077 T1439 T1440 arg1Of LMP1,contributes
R1078 T1440 T1437 arg2Of contributes,suggesting
R1079 T1440 T1438 arg1Of contributes,that
R1080 T1440 T1441 arg1Of contributes,to
R1081 T1440 T1444 arg1Of contributes,[
R1082 T1443 T1441 arg2Of development,to
R1083 T1443 T1442 arg1Of development,tumor
R1084 T1445 T1444 arg2Of 26,[
R1085 T1446 T1444 arg3Of ],[
R1086 T1449 T1447 arg1Of lymphomas,The
R1087 T1449 T1448 arg1Of lymphomas,LMP1
R1088 T1449 T1450 arg1Of lymphomas,have
R1089 T1449 T1451 arg1Of lymphomas,rearranged
R1090 T1449 T1455 arg1Of lymphomas,have
R1091 T1449 T1456 arg1Of lymphomas,activated
R1092 T1451 T1450 arg2Of rearranged,have
R1093 T1451 T1454 arg1Of rearranged,and
R1094 T1453 T1451 arg2Of genes,rearranged
R1095 T1453 T1452 arg1Of genes,Ig
R1096 T1456 T1454 arg2Of activated,and
R1097 T1456 T1455 arg2Of activated,have
R1098 T1456 T1465 arg1Of activated,","
R1099 T1456 T1466 arg1Of activated,with
R1100 T1456 T1475 arg1Of activated,[
R1101 T1457 T1458 arg1Of Akt,","
R1102 T1458 T1460 arg1Of ",",","
R1103 T1459 T1458 arg2Of JNK,","
R1104 T1460 T1463 arg1Of ",",and
R1105 T1461 T1460 arg2Of p38,","
R1106 T1463 T1456 arg2Of and,activated
R1107 T1463 T1462 arg1Of and,","
R1108 T1464 T1463 arg2Of NFκB,and
R1109 T1468 T1466 arg2Of activation,with
R1110 T1468 T1467 arg1Of activation,specific
R1111 T1468 T1469 arg1Of activation,of
R1112 T1474 T1469 arg2Of cRel,of
R1113 T1474 T1470 arg1Of cRel,the
R1114 T1474 T1471 arg1Of cRel,NFκB
R1115 T1474 T1472 arg1Of cRel,family
R1116 T1474 T1473 arg1Of cRel,member
R1117 T1476 T1475 arg2Of 27,[
R1118 T1477 T1475 arg3Of ],[
R1119 T1480 T1478 arg2Of study,In
R1120 T1480 T1479 arg1Of study,this
R1121 T1485 T1486 arg1Of lymphocytes,and
R1122 T1486 T1482 arg1Of and,the
R1123 T1486 T1483 arg1Of and,LMP1
R1124 T1486 T1484 arg1Of and,transgenic
R1125 T1486 T1488 arg1Of and,were
R1126 T1486 T1490 arg2Of and,characterized
R1127 T1487 T1486 arg2Of lymphomas,and
R1128 T1490 T1488 arg2Of characterized,were
R1129 T1490 T1489 arg1Of characterized,further
R1130 T1490 T1491 arg1Of characterized,and
R1131 T1491 T1478 arg1Of and,In
R1132 T1491 T1481 arg1Of and,","
R1133 T1494 T1492 arg1Of properties,their
R1134 T1494 T1493 arg1Of properties,growth
R1135 T1494 T1496 arg1Of properties,vitro
R1136 T1494 T1497 arg1Of properties,were
R1137 T1494 T1498 arg2Of properties,determined
R1138 T1496 T1495 arg1Of vitro,in
R1139 T1498 T1491 arg2Of determined,and
R1140 T1498 T1497 arg2Of determined,were
R1141 T1500 T1499 arg1Of obtain,To
R1142 T1500 T1506 arg1Of obtain,and
R1143 T1502 T1500 arg2Of populations,obtain
R1144 T1502 T1501 arg1Of populations,pure
R1145 T1502 T1503 arg1Of populations,of
R1146 T1505 T1503 arg2Of lymphocytes,of
R1147 T1505 T1504 arg1Of lymphocytes,malignant
R1148 T1508 T1506 arg2Of enable,and
R1149 T1508 T1507 arg1Of enable,to
R1150 T1510 T1509 arg1Of detailed,more
R1151 T1512 T1508 arg2Of analyses,enable
R1152 T1512 T1510 arg1Of analyses,detailed
R1153 T1512 T1511 arg1Of analyses,biochemical
R1154 T1514 T1515 arg1Of examples,of
R1155 T1514 T1518 arg1Of examples,were
R1156 T1514 T1519 arg2Of examples,inoculated
R1157 T1514 T1521 arg2Of examples,passaged
R1158 T1517 T1515 arg2Of lymphomas,of
R1159 T1533 T1531 arg2Of lymphocytes,to
R1160 T1533 T1532 arg1Of lymphocytes,B-1a
R1161 T1533 T1534 arg1Of lymphocytes,","
R1162 T1517 T1516 arg1Of lymphomas,primary
R1163 T1519 T1520 arg1Of inoculated,and
R1164 T1537 T1534 arg2Of population,","
R1165 T1537 T1535 arg1Of population,a
R1166 T1537 T1536 arg1Of population,self-replenishing
R1167 T1537 T1538 arg1Of population,of
R1168 T1539 T1538 arg2Of cells,of
R1169 T1539 T1540 arg1Of cells,that
R1170 T1539 T1541 arg1Of cells,are
R1171 T1539 T1542 arg1Of cells,prone
R1172 T1520 T1499 modOf and,To
R1173 T1542 T1541 arg2Of prone,are
R1174 T1542 T1543 arg1Of prone,to
R1175 T1520 T1507 modOf and,to
R1176 T1544 T1543 arg2Of malignancy,to
R1177 T1544 T1545 arg1Of malignancy,[
R1178 T1520 T1513 arg1Of and,","
R1179 T1546 T1545 arg2Of "28,29",[
R1180 T1520 T1518 arg2Of and,were
R1181 T1547 T1545 arg3Of ],[
R1182 T1520 T1522 arg1Of and,in
R1183 T1521 T1520 arg2Of passaged,and
R1184 T1550 T1548 arg1Of lymphocytes,LMP1
R1185 T1550 T1549 arg1Of lymphocytes,transgenic
R1186 T1550 T1551 arg1Of lymphocytes,had
R1187 T1550 T1552 arg1Of lymphocytes,increased
R1188 T1552 T1551 arg2Of increased,had
R1189 T1552 T1555 arg1Of increased,vitro
R1190 T1552 T1556 arg1Of increased,and
R1191 T1553 T1552 arg2Of viability,increased
R1192 T1555 T1554 arg1Of vitro,in
R1193 T1524 T1522 arg2Of mice,in
R1194 T1557 T1558 arg1Of viability,was
R1195 T1557 T1559 arg2Of viability,increased
R1196 T1559 T1556 arg2Of increased,and
R1197 T1559 T1558 arg2Of increased,was
R1198 T1559 T1560 arg1Of increased,by
R1199 T1562 T1560 arg2Of addition,by
R1200 T1562 T1561 arg1Of addition,the
R1201 T1562 T1563 arg1Of addition,of
R1202 T1524 T1523 arg1Of mice,SCID
R1203 T1564 T1563 arg2Of IL4,of
R1204 T1528 T1527 arg1Of development,lymphoma
R1205 T1566 T1565 arg2Of contrast,In
R1206 T1569 T1570 arg1Of LMP1-positive,and
R1207 T1528 T1529 arg1Of development,was
R1208 T1571 T1570 arg2Of -negative,and
R1209 T1528 T1530 arg1Of development,restricted
R1210 T1573 T1568 arg1Of cells,both
R1211 T1573 T1569 arg1Of cells,LMP1-positive
R1212 T1573 T1571 arg1Of cells,-negative
R1213 T1573 T1572 arg1Of cells,lymphoma
R1214 T1573 T1574 arg1Of cells,were
R1215 T1573 T1575 arg1Of cells,independent
R1216 T1574 T1565 arg1Of were,In
R1217 T1574 T1567 arg1Of were,","
R1218 T1574 T1584 arg1Of were,vitro
R1219 T1574 T1585 arg1Of were,with
R1220 T1575 T1574 arg2Of independent,were
R1221 T1575 T1576 arg1Of independent,of
R1222 T1529 T1525 arg1Of was,Interestingly
R1223 T1578 T1576 arg2Of co-stimulation,of
R1224 T1578 T1577 arg1Of co-stimulation,IL4
R1225 T1578 T1579 arg1Of co-stimulation,for
R1226 T1580 T1581 arg1Of survival,and
R1227 T1529 T1526 arg1Of was,","
R1228 T1581 T1579 arg2Of and,for
R1229 T1530 T1529 arg2Of restricted,was
R1230 T1582 T1581 arg2Of proliferation,and
R1231 T1530 T1531 arg1Of restricted,to
R1232 T1584 T1583 arg1Of vitro,in
R1233 T1628 T1625 arg2Of growth,blocked
R1234 T1588 T1585 arg2Of absence,with
R1235 T1588 T1586 arg1Of absence,a
R1236 T1588 T1587 arg1Of absence,complete
R1237 T1588 T1589 arg1Of absence,of
R1238 T1591 T1589 arg2Of Stat6,of
R1239 T1591 T1590 arg2Of Stat6,activated
R1240 T1591 T1592 arg1Of Stat6,","
R1241 T1628 T1626 arg1Of growth,the
R1242 T1595 T1592 arg2Of target,","
R1243 T1595 T1593 arg1Of target,the
R1244 T1595 T1594 arg1Of target,IL4
R1245 T1597 T1596 arg1Of lymphomas,The
R1246 T1597 T1598 arg1Of lymphomas,were
R1247 T1597 T1600 arg2Of lymphomas,distinguished
R1248 T1628 T1627 arg2Of growth,enhanced
R1249 T1628 T1629 arg1Of growth,of
R1250 T1600 T1598 arg2Of distinguished,were
R1251 T1600 T1599 arg1Of distinguished,also
R1252 T1632 T1633 arg1Of transgenic,and
R1253 T1603 T1602 arg1Of activation,constitutive
R1254 T1603 T1604 arg1Of activation,of
R1255 T1603 T1606 arg1Of activation,and
R1256 T1605 T1604 arg2Of Stat3,of
R1257 T1606 T1600 arg1Of and,distinguished
R1258 T1606 T1601 arg2Of and,by
R1259 T1634 T1633 arg2Of malignant,and
R1260 T1607 T1606 arg2Of deregulation,and
R1261 T1607 T1608 arg1Of deregulation,of
R1262 T1635 T1629 arg2Of lymphocytes,of
R1263 T1613 T1608 arg2Of pathway,of
R1264 T1613 T1609 arg1Of pathway,the
R1265 T1613 T1610 arg1Of pathway,Rb
R1266 T1613 T1611 arg1Of pathway,cell
R1267 T1613 T1612 arg1Of pathway,cycle
R1268 T1614 T1615 arg1Of Inhibition,of
R1269 T1614 T1625 arg1Of Inhibition,blocked
R1270 T1635 T1630 arg1Of lymphocytes,both
R1271 T1635 T1631 arg1Of lymphocytes,LMP1
R1272 T1617 T1618 arg1Of PI3K/Akt,","
R1273 T1635 T1632 arg1Of lymphocytes,transgenic
R1274 T1618 T1621 arg1Of ",",and
R1275 T1635 T1634 arg1Of lymphocytes,malignant
R1276 T1619 T1618 arg2Of NFκB,","
R1277 T1637 T1625 arg3Of suggesting,blocked
R1278 T1621 T1620 arg1Of and,","
R1279 T1622 T1621 arg2Of Stat3,and
R1280 T1640 T1639 arg1Of pathways,these
R1281 T1624 T1615 arg2Of pathways,of
R1282 T1624 T1616 arg1Of pathways,the
R1283 T1624 T1617 arg1Of pathways,PI3K/Akt
R1284 T1624 T1619 arg1Of pathways,NFκB
R1285 T1624 T1622 arg1Of pathways,Stat3
R1286 T1624 T1623 arg1Of pathways,signaling
R1287 T1625 T1636 arg1Of blocked,","
R1288 T1640 T1641 arg1Of pathways,are
R1289 T1640 T1642 arg2Of pathways,required
R1290 T1642 T1637 arg2Of required,suggesting
R1291 T1642 T1638 arg1Of required,that
R1292 T1642 T1641 arg2Of required,are
R1293 T1642 T1643 arg1Of required,for
R1294 T1645 T1646 arg1Of growth,and
R1295 T1646 T1643 arg2Of and,for
R1296 T1646 T1644 arg1Of and,their
R1297 T1647 T1646 arg2Of survival,and
R1299 T1648 T1649 arg1Of These,appear
R1302 T1648 T1651 arg1Of These,be
R1303 T1651 T1649 arg2Of be,appear
R1304 T1651 T1650 arg1Of be,to
R1305 T1654 T1651 arg2Of targets,be
R1306 T1654 T1652 arg1Of targets,the
R1307 T1654 T1653 arg1Of targets,same
R1308 T1654 T1655 arg1Of targets,that
R1309 T1654 T1656 arg1Of targets,are
R1310 T1654 T1657 arg2Of targets,deregulated
R1311 T1657 T1656 arg2Of deregulated,are
R1312 T1657 T1658 arg1Of deregulated,in
R1313 T1661 T1658 arg2Of lymphomas,in
R1314 T1661 T1659 arg1Of lymphomas,wild-type
R1315 T1661 T1660 arg1Of lymphomas,B-1a
R1316 T1661 T1662 arg1Of lymphomas,that
R1317 T1661 T1663 arg1Of lymphomas,arise
R1318 T1663 T1664 arg1Of arise,spontaneously
R1319 T1663 T1665 arg1Of arise,through
R1320 T1667 T1665 arg2Of predisposition,through
R1321 T1667 T1666 arg1Of predisposition,age
R1322 T1669 T1668 arg1Of study,This
R1323 T1669 T1670 arg1Of study,reveals
R1324 T1672 T1673 arg1Of LMP1,promotes
R1325 T1673 T1671 arg1Of promotes,that
R1326 T1673 T1683 arg1Of promotes,and
R1327 T1674 T1673 arg2Of malignancy,promotes
R1328 T1674 T1675 arg1Of malignancy,in
R1329 T1676 T1675 arg2Of cells,in
R1330 T1676 T1677 arg1Of cells,with
R1331 T1680 T1677 arg2Of ability,with
R1332 T1680 T1678 arg1Of ability,the
R1333 T1680 T1679 arg1Of ability,inherent
R1334 T1680 T1681 modOf ability,to
R1335 T1682 T1681 arg1Of proliferate,to
R1336 T1683 T1670 arg2Of and,reveals
R1337 T1684 T1683 arg2Of that,and
R1338 T1686 T1687 arg1Of Akt,","
R1339 T1687 T1690 arg1Of ",",and
R1340 T1688 T1687 arg2Of NFκB,","
R1341 T1690 T1689 arg1Of and,","
R1342 T1691 T1690 arg2Of Stat3,and
R1344 T1693 T1685 arg1Of pathways,the
R1349 T1693 T1686 arg1Of pathways,Akt
R1352 T1693 T1688 arg1Of pathways,NFκB
R1354 T1693 T1691 arg1Of pathways,Stat3
R1357 T1693 T1692 arg1Of pathways,signaling
R1359 T1693 T1694 arg1Of pathways,are
R1361 T1693 T1695 arg2Of pathways,required
R1363 T1695 T1684 arg2Of required,that
R1368 T1695 T1694 arg2Of required,are
R1369 T1695 T1696 arg1Of required,for
R1371 T1700 T1696 arg2Of effects,for
R1381 T1700 T1697 arg1Of effects,its
R1383 T1700 T1698 arg1Of effects,growth
R1385 T1700 T1699 arg1Of effects,stimulatory

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T1701 984-986 Anaphor denotes it
T1702 904-929 Antecedent denotes Latent membrane protein 1
T1703 4617-4633 Anaphor denotes the same targets
T1704 4404-4407 Antecedent denotes Akt
T1705 4419-4424 Antecedent denotes Stat3
R1298 T1701 T1702 boundBy it,Latent membrane protein 1
R1300 T1703 T1704 boundBy the same targets,Akt
R1301 T1703 T1705 boundBy the same targets,Stat3

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T1774 13-25 NNP denotes Epstein-Barr
T1775 26-31 NN denotes virus
T1776 32-33 -LRB- denotes (
T1777 33-36 NNP denotes EBV
T1778 36-37 -RRB- denotes )
T1779 38-40 VBZ denotes is
T1780 41-42 DT denotes a
T1781 43-53 JJ denotes ubiquitous
T1782 54-67 NN denotes γ-herpesvirus
T1783 68-72 WDT denotes that
T1784 73-80 VBZ denotes infects
T1785 81-87 NNS denotes humans
T1786 88-101 RB denotes predominantly
T1787 102-104 IN denotes at
T1788 105-107 DT denotes an
T1789 108-113 JJ denotes early
T1790 114-117 NN denotes age
T1791 118-122 IN denotes with
T1792 123-130 JJR denotes greater
T1793 131-135 IN denotes than
T1794 136-138 CD denotes 90
T1795 138-139 NN denotes %
T1796 140-142 IN denotes of
T1797 143-146 DT denotes the
T1798 147-152 NN denotes adult
T1799 153-163 NN denotes population
T1800 164-172 VBN denotes infected
T1801 173-177 IN denotes with
T1802 178-181 NNP denotes EBV
T1803 182-183 NNP denotes [
T1804 183-184 CD denotes 1
T1805 184-185 NNP denotes ]
T1806 185-186 . denotes .
T1807 187-190 NNP denotes EBV
T1808 191-193 VBZ denotes is
T1809 194-200 VBN denotes linked
T1810 201-203 TO denotes to
T1811 204-207 DT denotes the
T1812 208-219 NN denotes development
T1813 220-222 IN denotes of
T1814 223-227 DT denotes both
T1815 228-229 NNP denotes B
T1816 230-240 NN denotes lymphocyte
T1817 241-244 CC denotes and
T1818 245-255 JJ denotes epithelial
T1819 256-260 NN denotes cell
T1820 261-273 NNS denotes malignancies
T1821 273-274 , denotes ,
T1822 275-284 VBG denotes including
T1823 285-292 NNP denotes Burkitt
T1824 293-301 NN denotes lymphoma
T1825 301-302 , denotes ,
T1826 303-310 NNP denotes Hodgkin
T1827 311-318 NN denotes disease
T1828 319-320 -LRB- denotes (
T1829 320-322 NNP denotes HD
T1830 322-323 -RRB- denotes )
T1831 323-324 , denotes ,
T1832 325-328 CC denotes and
T1833 329-343 JJ denotes nasopharyngeal
T1834 344-353 NN denotes carcinoma
T1835 354-355 -LRB- denotes (
T1836 355-358 NNP denotes NPC
T1837 358-359 -RRB- denotes )
T1838 359-360 , denotes ,
T1839 361-364 CC denotes and
T1840 365-372 NNS denotes cancers
T1841 373-379 VBN denotes linked
T1842 380-382 TO denotes to
T1843 383-400 NN denotes immunosuppression
T1844 400-401 , denotes ,
T1845 402-411 VBG denotes including
T1846 412-427 JJ denotes post-transplant
T1847 428-436 NN denotes lymphoma
T1848 437-440 CC denotes and
T1849 441-456 JJ denotes AIDS-associated
T1850 457-466 NNS denotes lymphomas
T1851 467-468 NNP denotes [
T1852 468-471 CD denotes 2,3
T1853 471-472 NNP denotes ]
T1854 472-473 . denotes .
T1855 474-476 IN denotes In
T1856 477-482 NN denotes vitro
T1857 483-492 NN denotes infection
T1858 493-495 IN denotes of
T1859 496-497 NNP denotes B
T1860 498-509 NNS denotes lymphocytes
T1861 510-514 IN denotes with
T1862 515-518 NNP denotes EBV
T1863 519-526 VBZ denotes induces
T1864 527-536 JJ denotes permanent
T1865 537-543 NN denotes growth
T1866 544-558 NN denotes transformation
T1867 558-559 , denotes ,
T1868 560-563 CC denotes and
T1869 564-568 DT denotes this
T1870 569-576 NN denotes ability
T1871 577-579 TO denotes to
T1872 580-586 VB denotes affect
T1873 587-591 NN denotes cell
T1874 592-598 NN denotes growth
T1875 599-609 NN denotes regulation
T1876 610-616 JJ denotes likely
T1877 617-628 VBZ denotes contributes
T1878 629-631 TO denotes to
T1879 632-635 DT denotes the
T1880 636-647 NN denotes development
T1881 648-650 IN denotes of
T1882 651-657 NN denotes cancer
T1883 657-658 . denotes .
T1884 659-663 JJ denotes Many
T1885 664-666 IN denotes of
T1886 667-670 DT denotes the
T1887 671-676 JJ denotes viral
T1888 677-685 NNS denotes proteins
T1889 686-695 VBN denotes expressed
T1890 696-698 IN denotes in
T1891 699-710 VBN denotes transformed
T1892 711-716 NNS denotes cells
T1893 716-717 , denotes ,
T1894 718-727 VBG denotes including
T1895 728-731 DT denotes the
T1896 732-735 NNP denotes EBV
T1897 736-743 JJ denotes nuclear
T1898 744-752 NNS denotes antigens
T1899 753-756 CC denotes and
T1900 757-763 NN denotes latent
T1901 764-772 NN denotes membrane
T1902 773-781 NNS denotes proteins
T1903 781-782 , denotes ,
T1904 783-787 VBP denotes have
T1905 788-796 JJ denotes profound
T1906 797-804 NNS denotes effects
T1907 805-807 IN denotes on
T1908 808-812 NN denotes cell
T1909 813-819 NN denotes growth
T1910 820-830 NN denotes regulation
T1911 831-834 CC denotes and
T1912 835-838 VBP denotes are
T1913 839-847 VBN denotes required
T1914 848-851 IN denotes for
T1915 852-855 NNP denotes EBV
T1916 856-862 NN denotes latent
T1917 863-872 NN denotes infection
T1918 873-876 CC denotes and
T1919 877-878 NNP denotes B
T1920 879-883 NN denotes cell
T1921 884-898 NN denotes transformation
T1922 899-900 NNP denotes [
T1923 900-901 CD denotes 1
T1924 901-902 NNP denotes ]
T1925 902-903 . denotes .
T1926 904-910 NN denotes Latent
T1927 911-919 NN denotes membrane
T1928 920-927 NN denotes protein
T1929 928-929 CD denotes 1
T1930 930-931 -LRB- denotes (
T1931 931-935 CD denotes LMP1
T1932 935-936 -RRB- denotes )
T1933 937-939 VBZ denotes is
T1934 940-950 VBN denotes considered
T1935 951-954 DT denotes the
T1936 955-960 JJ denotes major
T1937 961-972 NN denotes oncoprotein
T1938 973-975 IN denotes of
T1939 976-979 NNP denotes EBV
T1940 979-980 , denotes ,
T1941 981-983 IN denotes as
T1942 984-986 PRP denotes it
T1943 987-997 VBZ denotes transforms
T1944 998-1004 JJ denotes rodent
T1945 1005-1016 NNS denotes fibroblasts
T1946 1017-1019 TO denotes to
T1947 1020-1034 NN denotes tumorigenicity
T1948 1035-1037 IN denotes in
T1949 1038-1042 JJ denotes nude
T1950 1043-1047 NNS denotes mice
T1951 1048-1051 CC denotes and
T1952 1052-1054 VBZ denotes is
T1953 1055-1064 VBN denotes expressed
T1954 1065-1067 IN denotes in
T1955 1068-1070 NNP denotes HD
T1956 1070-1071 , denotes ,
T1957 1072-1075 NNP denotes NPC
T1958 1075-1076 , denotes ,
T1959 1077-1080 CC denotes and
T1960 1081-1109 JJ denotes immunosuppression-associated
T1961 1110-1116 NNS denotes tumors
T1962 1117-1118 VBP denotes [
T1963 1118-1119 CD denotes 4
T1964 1120-1121 CD denotes 8
T1965 1121-1122 NNP denotes ]
T1966 1122-1123 . denotes .
T1967 1124-1126 IN denotes In
T1968 1127-1128 NNP denotes B
T1969 1129-1140 NNS denotes lymphocytes
T1970 1140-1141 , denotes ,
T1971 1142-1146 NNP denotes LMP1
T1972 1147-1153 NNS denotes mimics
T1973 1154-1158 NNP denotes CD40
T1974 1159-1168 VBG denotes signaling
T1975 1168-1169 , denotes ,
T1976 1170-1173 CC denotes and
T1977 1174-1178 DT denotes both
T1978 1179-1183 CD denotes LMP1
T1979 1184-1187 CC denotes and
T1980 1188-1192 CD denotes CD40
T1981 1193-1196 VBP denotes are
T1982 1197-1206 JJ denotes essential
T1983 1207-1210 IN denotes for
T1984 1211-1223 JJ denotes EBV-mediated
T1985 1224-1225 NNP denotes B
T1986 1226-1230 NN denotes cell
T1987 1231-1245 NN denotes transformation
T1988 1246-1247 NN denotes [
T1989 1247-1248 CD denotes 9
T1990 1249-1251 CD denotes 11
T1991 1251-1252 NN denotes ]
T1992 1252-1253 . denotes .
T1993 1254-1259 IN denotes While
T1994 1260-1264 CD denotes CD40
T1995 1265-1274 NNS denotes interacts
T1996 1275-1279 IN denotes with
T1997 1280-1284 JJ denotes CD40
T1998 1285-1291 NN denotes ligand
T1999 1292-1301 VBN denotes expressed
T2000 1302-1304 IN denotes on
T2001 1305-1314 VBN denotes activated
T2002 1315-1316 NNP denotes T
T2003 1317-1322 NNS denotes cells
T2004 1323-1325 TO denotes to
T2005 1326-1332 VB denotes induce
T2006 1333-1334 NNP denotes B
T2007 1335-1339 NN denotes cell
T2008 1340-1350 NN denotes activation
T2009 1351-1354 CC denotes and
T2010 1355-1370 NN denotes differentiation
T2011 1370-1371 , denotes ,
T2012 1372-1376 NNP denotes LMP1
T2013 1377-1381 VBZ denotes acts
T2014 1382-1384 IN denotes as
T2015 1385-1386 DT denotes a
T2016 1387-1399 JJ denotes constitutive
T2017 1400-1406 NN denotes signal
T2018 1407-1414 IN denotes through
T2019 1415-1433 JJ denotes ligand-independent
T2020 1434-1449 NN denotes oligomerization
T2021 1449-1450 . denotes .
T2022 1451-1455 CD denotes LMP1
T2023 1456-1459 CC denotes and
T2024 1460-1464 CD denotes CD40
T2025 1465-1473 NN denotes interact
T2026 1474-1478 IN denotes with
T2027 1479-1482 DT denotes the
T2028 1483-1487 JJ denotes same
T2029 1488-1493 NN denotes tumor
T2030 1494-1502 NN denotes necrosis
T2031 1503-1509 NN denotes factor
T2032 1510-1518 NN denotes receptor
T2033 1519-1529 VBN denotes associated
T2034 1530-1537 NNS denotes factors
T2035 1538-1539 -LRB- denotes (
T2036 1539-1544 NNS denotes TRAFs
T2037 1544-1545 -RRB- denotes )
T2038 1546-1553 VBG denotes leading
T2039 1554-1556 TO denotes to
T2040 1557-1567 NN denotes activation
T2041 1568-1570 IN denotes of
T2042 1571-1575 NNP denotes NFκB
T2043 1575-1576 , denotes ,
T2044 1577-1582 NNP denotes c-Jun
T2045 1583-1584 NNP denotes N
T2046 1585-1593 NN denotes terminal
T2047 1594-1600 NN denotes kinase
T2048 1601-1602 -LRB- denotes (
T2049 1602-1605 NNP denotes JNK
T2050 1605-1606 -RRB- denotes )
T2051 1606-1607 , denotes ,
T2052 1608-1611 CC denotes and
T2053 1612-1615 CD denotes p38
T2054 1616-1620 NNP denotes MAPK
T2055 1621-1630 VBG denotes signaling
T2056 1631-1639 NNS denotes pathways
T2057 1640-1641 NNP denotes [
T2058 1641-1643 CD denotes 12
T2059 1644-1646 CD denotes 16
T2060 1646-1647 NN denotes ]
T2061 1647-1648 . denotes .
T2062 1649-1659 NNP denotes Activation
T2063 1660-1662 IN denotes of
T2064 1663-1667 NNP denotes NFκB
T2065 1668-1670 VBZ denotes is
T2066 1671-1679 VBN denotes required
T2067 1680-1683 IN denotes for
T2068 1684-1695 JJ denotes EBV-induced
T2069 1696-1697 NNP denotes B
T2070 1698-1702 NN denotes cell
T2071 1703-1717 NN denotes transformation
T2072 1718-1721 CC denotes and
T2073 1722-1725 PRP$ denotes its
T2074 1726-1736 NN denotes inhibition
T2075 1737-1744 RB denotes rapidly
T2076 1745-1752 NNS denotes results
T2077 1753-1755 IN denotes in
T2078 1756-1760 NN denotes cell
T2079 1761-1766 NN denotes death
T2080 1767-1768 NNP denotes [
T2081 1768-1773 CD denotes 17,18
T2082 1773-1774 NNP denotes ]
T2083 1774-1775 . denotes .
T2084 1776-1782 JJ denotes Recent
T2085 1783-1790 NNS denotes studies
T2086 1791-1799 VBP denotes indicate
T2087 1800-1804 IN denotes that
T2088 1805-1809 NNP denotes LMP1
T2089 1810-1814 RB denotes also
T2090 1815-1824 VBZ denotes activates
T2091 1825-1845 NN denotes phosphatidylinositol
T2092 1846-1847 CD denotes 3
T2093 1848-1854 NN denotes kinase
T2094 1855-1856 -LRB- denotes (
T2095 1856-1860 NNP denotes PI3K
T2096 1860-1861 -RRB- denotes )
T2097 1861-1862 VBP denotes /
T2098 1862-1865 NNP denotes Akt
T2099 1866-1875 VBG denotes signaling
T2100 1876-1879 CC denotes and
T2101 1880-1884 IN denotes that
T2102 1885-1889 DT denotes this
T2103 1890-1900 NN denotes activation
T2104 1901-1903 VBZ denotes is
T2105 1904-1912 VBN denotes required
T2106 1913-1916 IN denotes for
T2107 1917-1930 JJ denotes LMP1-mediated
T2108 1931-1945 NN denotes transformation
T2109 1946-1948 IN denotes of
T2110 1949-1955 NN denotes rodent
T2111 1956-1967 NNS denotes fibroblasts
T2112 1968-1969 NNP denotes [
T2113 1969-1973 CD denotes 5,19
T2114 1973-1974 NNP denotes ]
T2115 1974-1975 . denotes .
T2116 1976-1978 IN denotes In
T2117 1979-1984 NN denotes vitro
T2118 1984-1985 , denotes ,
T2119 1986-1993 JJ denotes primary
T2120 1994-1995 NNP denotes B
T2121 1996-2001 NNS denotes cells
T2122 2002-2005 MD denotes can
T2123 2006-2008 VB denotes be
T2124 2009-2019 VBN denotes maintained
T2125 2020-2022 IN denotes by
T2126 2023-2027 NNP denotes CD40
T2127 2028-2036 NN denotes ligation
T2128 2037-2039 IN denotes in
T2129 2040-2051 NN denotes combination
T2130 2052-2056 IN denotes with
T2131 2057-2060 CD denotes IL4
T2132 2061-2070 NN denotes treatment
T2133 2070-2071 . denotes .
T2134 2072-2074 IN denotes In
T2135 2075-2079 NN denotes vivo
T2136 2079-2080 , denotes ,
T2137 2081-2085 NNP denotes CD40
T2138 2086-2095 VBG denotes signaling
T2139 2096-2098 VBZ denotes is
T2140 2099-2108 JJ denotes necessary
T2141 2109-2112 IN denotes for
T2142 2113-2121 JJ denotes germinal
T2143 2122-2128 NN denotes center
T2144 2129-2130 -LRB- denotes (
T2145 2130-2132 NNP denotes GC
T2146 2132-2133 -RRB- denotes )
T2147 2134-2143 NN denotes formation
T2148 2144-2148 JJ denotes such
T2149 2149-2153 IN denotes that
T2150 2154-2158 NNS denotes mice
T2151 2159-2168 NN denotes deficient
T2152 2169-2172 IN denotes for
T2153 2173-2177 NNP denotes CD40
T2154 2178-2180 CC denotes or
T2155 2181-2186 NNP denotes CD40L
T2156 2187-2190 VBP denotes are
T2157 2191-2197 JJ denotes unable
T2158 2198-2200 TO denotes to
T2159 2201-2205 VB denotes form
T2160 2206-2209 NNS denotes GCs
T2161 2210-2212 IN denotes in
T2162 2213-2221 NN denotes response
T2163 2222-2224 TO denotes to
T2164 2225-2226 NNP denotes T
T2165 2227-2231 NN denotes cell
T2166 2232-2241 JJ denotes dependent
T2167 2242-2250 NNS denotes antigens
T2168 2251-2252 NNP denotes [
T2169 2252-2257 CD denotes 20,21
T2170 2257-2258 NNP denotes ]
T2171 2258-2259 . denotes .
T2172 2260-2264 DT denotes Both
T2173 2265-2268 DT denotes the
T2174 2269-2277 NN denotes membrane
T2175 2278-2286 NN denotes proximal
T2176 2287-2290 CC denotes and
T2177 2291-2297 JJ denotes distal
T2178 2298-2309 JJ denotes cytoplasmic
T2179 2310-2317 NNS denotes regions
T2180 2318-2320 IN denotes of
T2181 2321-2325 NNP denotes CD40
T2182 2326-2330 IN denotes that
T2183 2331-2335 NN denotes bind
T2184 2336-2341 CD denotes TRAF6
T2185 2342-2345 CC denotes and
T2186 2346-2356 CD denotes TRAFs2/3/5
T2187 2356-2357 , denotes ,
T2188 2358-2370 RB denotes respectively
T2189 2370-2371 , denotes ,
T2190 2372-2375 VBP denotes are
T2191 2376-2385 JJ denotes necessary
T2192 2386-2389 IN denotes for
T2193 2390-2392 NNP denotes GC
T2194 2393-2402 NN denotes formation
T2195 2402-2403 , denotes ,
T2196 2404-2407 CC denotes but
T2197 2408-2414 DT denotes either
T2198 2415-2421 NN denotes region
T2199 2422-2424 VBZ denotes is
T2200 2425-2435 JJ denotes sufficient
T2201 2436-2438 TO denotes to
T2202 2439-2445 VB denotes induce
T2203 2446-2461 JJ denotes extrafollicular
T2204 2462-2463 NNP denotes B
T2205 2464-2468 NN denotes cell
T2206 2469-2484 NN denotes differentiation
T2207 2485-2488 CC denotes and
T2208 2489-2496 VB denotes restore
T2209 2497-2500 JJ denotes low
T2210 2501-2509 NN denotes affinity
T2211 2510-2518 NN denotes antibody
T2212 2519-2529 NN denotes production
T2213 2530-2531 NNP denotes [
T2214 2531-2533 CD denotes 22
T2215 2533-2534 NNP denotes ]
T2216 2534-2535 . denotes .
T2217 2536-2548 RB denotes Functionally
T2218 2548-2549 , denotes ,
T2219 2550-2554 NNP denotes LMP1
T2220 2555-2558 MD denotes can
T2221 2559-2565 VB denotes rescue
T2222 2566-2580 JJ denotes CD40-deficient
T2223 2581-2585 NNS denotes mice
T2224 2586-2589 CC denotes and
T2225 2590-2597 VB denotes restore
T2226 2598-2612 NN denotes immunoglobulin
T2227 2613-2614 -LRB- denotes (
T2228 2614-2616 NNP denotes Ig
T2229 2616-2617 -RRB- denotes )
T2230 2618-2623 NN denotes class
T2231 2624-2633 NN denotes switching
T2232 2633-2634 , denotes ,
T2233 2635-2639 RBS denotes most
T2234 2640-2646 JJ denotes likely
T2235 2647-2654 IN denotes because
T2236 2655-2659 CD denotes LMP1
T2237 2660-2668 NNS denotes recruits
T2238 2669-2676 JJ denotes similar
T2239 2677-2681 NNP denotes TRAF
T2240 2682-2691 NNS denotes molecules
T2241 2691-2692 , denotes ,
T2242 2693-2698 VBZ denotes TRAFs
T2243 2699-2704 CD denotes 1/2/3
T2244 2704-2705 NN denotes /
T2245 2705-2706 CD denotes 5
T2246 2707-2710 CC denotes and
T2247 2711-2716 CD denotes TRAF6
T2248 2716-2717 , denotes ,
T2249 2718-2725 IN denotes through
T2250 2726-2729 DT denotes the
T2251 2730-2740 JJ denotes C-terminal
T2252 2741-2751 NN denotes activation
T2253 2752-2759 NNS denotes regions
T2254 2760-2761 CD denotes 1
T2255 2762-2765 CC denotes and
T2256 2766-2767 CD denotes 2
T2257 2768-2775 NNS denotes domains
T2258 2775-2776 , denotes ,
T2259 2777-2789 RB denotes respectively
T2260 2789-2790 . denotes .
T2261 2791-2798 RB denotes However
T2262 2798-2799 , denotes ,
T2263 2800-2804 NNP denotes LMP1
T2264 2805-2807 VBZ denotes is
T2265 2808-2814 JJ denotes unable
T2266 2815-2817 TO denotes to
T2267 2818-2825 VB denotes restore
T2268 2826-2834 NN denotes affinity
T2269 2835-2845 NN denotes maturation
T2270 2846-2849 CC denotes and
T2271 2850-2852 NNP denotes GC
T2272 2853-2862 NN denotes formation
T2273 2863-2864 NNP denotes [
T2274 2864-2866 CD denotes 23
T2275 2866-2867 NNP denotes ]
T2276 2867-2868 . denotes .
T2277 2869-2876 JJ denotes Several
T2278 2877-2880 NNP denotes EBV
T2279 2881-2893 VBG denotes transforming
T2280 2894-2902 NNS denotes proteins
T2281 2903-2907 VBP denotes have
T2282 2908-2912 VBN denotes been
T2283 2913-2920 VBN denotes studied
T2284 2921-2923 IN denotes in
T2285 2924-2934 JJ denotes transgenic
T2286 2935-2940 NN denotes mouse
T2287 2941-2947 NNS denotes models
T2288 2947-2948 , denotes ,
T2289 2949-2956 RB denotes however
T2290 2956-2957 , denotes ,
T2291 2958-2962 RB denotes only
T2292 2963-2967 CD denotes LMP1
T2293 2968-2975 VBZ denotes induces
T2294 2976-2981 NN denotes tumor
T2295 2982-2993 NN denotes development
T2296 2994-2998 WRB denotes when
T2297 2999-3008 VBN denotes expressed
T2298 3009-3014 IN denotes under
T2299 3015-3018 DT denotes the
T2300 3019-3026 NN denotes control
T2301 3027-3029 IN denotes of
T2302 3030-3033 DT denotes the
T2303 3034-3036 NNP denotes Ig
T2304 3037-3042 JJ denotes heavy
T2305 3043-3048 NN denotes chain
T2306 3049-3057 NN denotes promoter
T2307 3058-3061 CC denotes and
T2308 3062-3070 NN denotes enhancer
T2309 3071-3072 NNP denotes [
T2310 3072-3074 CD denotes 24
T2311 3075-3077 CD denotes 26
T2312 3077-3078 NN denotes ]
T2313 3078-3079 . denotes .
T2314 3080-3083 DT denotes The
T2315 3084-3088 NNP denotes LMP1
T2316 3089-3099 NN denotes transgenic
T2317 3100-3104 NNS denotes mice
T2318 3105-3106 -LRB- denotes (
T2319 3106-3112 NNP denotes IgLMP1
T2320 3112-3113 -RRB- denotes )
T2321 3114-3121 VBP denotes express
T2322 3122-3126 CD denotes LMP1
T2323 3127-3129 IN denotes in
T2324 3130-3131 NNP denotes B
T2325 3132-3143 NNS denotes lymphocytes
T2326 3143-3144 , denotes ,
T2327 3145-3148 CC denotes and
T2328 3149-3151 IN denotes in
T2329 3152-3156 NNS denotes mice
T2330 3157-3162 JJR denotes older
T2331 3163-3167 IN denotes than
T2332 3168-3170 CD denotes 12
T2333 3171-3173 NN denotes mo
T2334 3173-3174 , denotes ,
T2335 3175-3183 NN denotes lymphoma
T2336 3184-3192 VBZ denotes develops
T2337 3193-3197 IN denotes with
T2338 3198-3207 VBN denotes increased
T2339 3208-3217 NN denotes incidence
T2340 3218-3219 -LRB- denotes (
T2341 3219-3221 CD denotes 40
T2342 3221-3222 NN denotes %
T2343 3223-3225 CD denotes 50
T2344 3225-3226 NN denotes %
T2345 3226-3227 -RRB- denotes )
T2346 3228-3236 VBN denotes compared
T2347 3237-3239 TO denotes to
T2348 3240-3249 JJ denotes wild-type
T2349 3250-3257 NN denotes control
T2350 3258-3262 NNS denotes mice
T2351 3263-3264 -LRB- denotes (
T2352 3264-3266 CD denotes 11
T2353 3266-3267 NN denotes %
T2354 3267-3268 -RRB- denotes )
T2355 3268-3269 , denotes ,
T2356 3270-3280 VBG denotes suggesting
T2357 3281-3285 IN denotes that
T2358 3286-3290 CD denotes LMP1
T2359 3291-3302 VBZ denotes contributes
T2360 3303-3305 TO denotes to
T2361 3306-3311 NN denotes tumor
T2362 3312-3323 NN denotes development
T2363 3324-3325 NNP denotes [
T2364 3325-3327 CD denotes 26
T2365 3327-3328 NNP denotes ]
T2366 3328-3329 . denotes .
T2367 3330-3333 DT denotes The
T2368 3334-3338 NNP denotes LMP1
T2369 3339-3348 NNS denotes lymphomas
T2370 3349-3353 VBP denotes have
T2371 3354-3364 VBN denotes rearranged
T2372 3365-3367 NNP denotes Ig
T2373 3368-3373 NNS denotes genes
T2374 3374-3377 CC denotes and
T2375 3378-3382 VBP denotes have
T2376 3383-3392 VBN denotes activated
T2377 3393-3396 NNP denotes Akt
T2378 3396-3397 , denotes ,
T2379 3398-3401 NNP denotes JNK
T2380 3401-3402 , denotes ,
T2381 3403-3406 CD denotes p38
T2382 3406-3407 , denotes ,
T2383 3408-3411 CC denotes and
T2384 3412-3416 NNP denotes NFκB
T2385 3416-3417 , denotes ,
T2386 3418-3422 IN denotes with
T2387 3423-3431 JJ denotes specific
T2388 3432-3442 NN denotes activation
T2389 3443-3445 IN denotes of
T2390 3446-3449 DT denotes the
T2391 3450-3454 NNP denotes NFκB
T2392 3455-3461 NN denotes family
T2393 3462-3468 NN denotes member
T2394 3469-3473 NNP denotes cRel
T2395 3474-3475 NNP denotes [
T2396 3475-3477 CD denotes 27
T2397 3477-3478 NNP denotes ]
T2398 3478-3479 . denotes .
T2399 3480-3482 IN denotes In
T2400 3483-3487 DT denotes this
T2401 3488-3493 NN denotes study
T2402 3493-3494 , denotes ,
T2403 3495-3498 DT denotes the
T2404 3499-3503 NNP denotes LMP1
T2405 3504-3514 NN denotes transgenic
T2406 3515-3526 NNS denotes lymphocytes
T2407 3527-3530 CC denotes and
T2408 3531-3540 NNS denotes lymphomas
T2409 3541-3545 VBD denotes were
T2410 3546-3553 JJ denotes further
T2411 3554-3567 VBN denotes characterized
T2412 3568-3571 CC denotes and
T2413 3572-3577 PRP$ denotes their
T2414 3578-3584 NN denotes growth
T2415 3585-3595 NNS denotes properties
T2416 3596-3598 IN denotes in
T2417 3599-3604 NN denotes vitro
T2418 3605-3609 VBD denotes were
T2419 3610-3620 VBN denotes determined
T2420 3620-3621 . denotes .
T2421 3622-3624 TO denotes To
T2422 3625-3631 VB denotes obtain
T2423 3632-3636 JJ denotes pure
T2424 3637-3648 NNS denotes populations
T2425 3649-3651 IN denotes of
T2426 3652-3661 JJ denotes malignant
T2427 3662-3673 NNS denotes lymphocytes
T2428 3674-3677 CC denotes and
T2429 3678-3680 TO denotes to
T2430 3681-3687 VB denotes enable
T2431 3688-3692 JJR denotes more
T2432 3693-3701 JJ denotes detailed
T2433 3702-3713 NN denotes biochemical
T2434 3714-3722 NNS denotes analyses
T2435 3722-3723 , denotes ,
T2436 3724-3732 NNS denotes examples
T2437 3733-3735 IN denotes of
T2438 3736-3743 JJ denotes primary
T2439 3744-3753 NNS denotes lymphomas
T2440 3754-3758 VBD denotes were
T2441 3759-3769 VBN denotes inoculated
T2442 3770-3773 CC denotes and
T2443 3774-3782 VBN denotes passaged
T2444 3783-3785 IN denotes in
T2445 3786-3790 NNP denotes SCID
T2446 3791-3795 NNS denotes mice
T2447 3795-3796 . denotes .
T2448 3797-3810 RB denotes Interestingly
T2449 3810-3811 , denotes ,
T2450 3812-3820 NN denotes lymphoma
T2451 3821-3832 NN denotes development
T2452 3833-3836 VBD denotes was
T2453 3837-3847 VBN denotes restricted
T2454 3848-3850 TO denotes to
T2455 3851-3855 JJ denotes B-1a
T2456 3856-3867 NNS denotes lymphocytes
T2457 3867-3868 , denotes ,
T2458 3869-3870 DT denotes a
T2459 3871-3888 JJ denotes self-replenishing
T2460 3889-3899 NN denotes population
T2461 3900-3902 IN denotes of
T2462 3903-3908 NNS denotes cells
T2463 3909-3913 WDT denotes that
T2464 3914-3917 VBP denotes are
T2465 3918-3923 JJ denotes prone
T2466 3924-3926 TO denotes to
T2467 3927-3937 NN denotes malignancy
T2468 3938-3939 NNP denotes [
T2469 3939-3944 CD denotes 28,29
T2470 3944-3945 NNP denotes ]
T2471 3945-3946 . denotes .
T2472 3947-3951 CD denotes LMP1
T2473 3952-3962 JJ denotes transgenic
T2474 3963-3974 NNS denotes lymphocytes
T2475 3975-3978 VBD denotes had
T2476 3979-3988 VBN denotes increased
T2477 3989-3998 NN denotes viability
T2478 3999-4001 IN denotes in
T2479 4002-4007 NN denotes vitro
T2480 4008-4011 CC denotes and
T2481 4012-4021 NN denotes viability
T2482 4022-4025 VBD denotes was
T2483 4026-4035 VBN denotes increased
T2484 4036-4038 IN denotes by
T2485 4039-4042 DT denotes the
T2486 4043-4051 NN denotes addition
T2487 4052-4054 IN denotes of
T2488 4055-4058 NNP denotes IL4
T2489 4058-4059 . denotes .
T2490 4060-4062 IN denotes In
T2491 4063-4071 NN denotes contrast
T2492 4071-4072 , denotes ,
T2493 4073-4077 DT denotes both
T2494 4078-4091 JJ denotes LMP1-positive
T2495 4092-4095 CC denotes and
T2496 4096-4097 : denotes -
T2497 4097-4105 JJ denotes negative
T2498 4106-4114 NN denotes lymphoma
T2499 4115-4120 NNS denotes cells
T2500 4121-4125 VBD denotes were
T2501 4126-4137 JJ denotes independent
T2502 4138-4140 IN denotes of
T2503 4141-4144 CD denotes IL4
T2504 4145-4159 NN denotes co-stimulation
T2505 4160-4163 IN denotes for
T2506 4164-4172 NN denotes survival
T2507 4173-4176 CC denotes and
T2508 4177-4190 NN denotes proliferation
T2509 4191-4193 IN denotes in
T2510 4194-4199 NN denotes vitro
T2511 4200-4204 IN denotes with
T2512 4205-4206 DT denotes a
T2513 4207-4215 JJ denotes complete
T2514 4216-4223 NN denotes absence
T2515 4224-4226 IN denotes of
T2516 4227-4236 VBN denotes activated
T2517 4237-4242 NNP denotes Stat6
T2518 4242-4243 , denotes ,
T2519 4244-4247 DT denotes the
T2520 4248-4251 NNP denotes IL4
T2521 4252-4258 NN denotes target
T2522 4258-4259 . denotes .
T2523 4260-4263 DT denotes The
T2524 4264-4273 NNS denotes lymphomas
T2525 4274-4278 VBD denotes were
T2526 4279-4283 RB denotes also
T2527 4284-4297 VBN denotes distinguished
T2528 4298-4300 IN denotes by
T2529 4301-4313 JJ denotes constitutive
T2530 4314-4324 NN denotes activation
T2531 4325-4327 IN denotes of
T2532 4328-4333 NNP denotes Stat3
T2533 4334-4337 CC denotes and
T2534 4338-4350 NN denotes deregulation
T2535 4351-4353 IN denotes of
T2536 4354-4357 DT denotes the
T2537 4358-4360 NNP denotes Rb
T2538 4361-4365 NN denotes cell
T2539 4366-4371 NN denotes cycle
T2540 4372-4379 NN denotes pathway
T2541 4379-4380 . denotes .
T2542 4381-4391 NNP denotes Inhibition
T2543 4392-4394 IN denotes of
T2544 4395-4398 DT denotes the
T2545 4399-4407 NNP denotes PI3K/Akt
T2546 4407-4408 , denotes ,
T2547 4409-4413 NNP denotes NFκB
T2548 4413-4414 , denotes ,
T2549 4415-4418 CC denotes and
T2550 4419-4424 JJ denotes Stat3
T2551 4425-4434 VBG denotes signaling
T2552 4435-4443 NNS denotes pathways
T2553 4444-4451 VBD denotes blocked
T2554 4452-4455 DT denotes the
T2555 4456-4464 JJ denotes enhanced
T2556 4465-4471 NN denotes growth
T2557 4472-4474 IN denotes of
T2558 4475-4479 DT denotes both
T2559 4480-4484 CD denotes LMP1
T2560 4485-4495 NN denotes transgenic
T2561 4496-4499 CC denotes and
T2562 4500-4509 JJ denotes malignant
T2563 4510-4521 NNS denotes lymphocytes
T2564 4521-4522 , denotes ,
T2565 4523-4533 VBG denotes suggesting
T2566 4534-4538 IN denotes that
T2567 4539-4544 DT denotes these
T2568 4545-4553 NNS denotes pathways
T2569 4554-4557 VBP denotes are
T2570 4558-4566 VBN denotes required
T2571 4567-4570 IN denotes for
T2572 4571-4576 PRP$ denotes their
T2573 4577-4583 NN denotes growth
T2574 4584-4587 CC denotes and
T2575 4588-4596 NN denotes survival
T2576 4596-4597 . denotes .
T2577 4598-4603 DT denotes These
T2578 4604-4610 VBP denotes appear
T2579 4611-4613 TO denotes to
T2580 4614-4616 VB denotes be
T2581 4617-4620 DT denotes the
T2582 4621-4625 JJ denotes same
T2583 4626-4633 NNS denotes targets
T2584 4634-4638 WDT denotes that
T2585 4639-4642 VBP denotes are
T2586 4643-4654 VBN denotes deregulated
T2587 4655-4657 IN denotes in
T2588 4658-4667 JJ denotes wild-type
T2589 4668-4672 NN denotes B-1a
T2590 4673-4682 NNS denotes lymphomas
T2591 4683-4687 WDT denotes that
T2592 4688-4693 VBP denotes arise
T2593 4694-4707 RB denotes spontaneously
T2594 4708-4715 IN denotes through
T2595 4716-4719 NN denotes age
T2596 4720-4734 NN denotes predisposition
T2597 4734-4735 . denotes .
T2598 4736-4740 DT denotes This
T2599 4741-4746 NN denotes study
T2600 4747-4754 VBZ denotes reveals
T2601 4755-4759 IN denotes that
T2602 4760-4764 CD denotes LMP1
T2603 4765-4773 VBZ denotes promotes
T2604 4774-4784 NN denotes malignancy
T2605 4785-4787 IN denotes in
T2606 4788-4793 NNS denotes cells
T2607 4794-4798 IN denotes with
T2608 4799-4802 DT denotes the
T2609 4803-4811 JJ denotes inherent
T2610 4812-4819 NN denotes ability
T2611 4820-4822 TO denotes to
T2612 4823-4834 VB denotes proliferate
T2613 4835-4838 CC denotes and
T2614 4839-4843 IN denotes that
T2615 4844-4847 DT denotes the
T2616 4848-4851 NNP denotes Akt
T2617 4851-4852 , denotes ,
T2618 4853-4857 NNP denotes NFκB
T2619 4857-4858 , denotes ,
T2620 4859-4862 CC denotes and
T2621 4863-4868 JJ denotes Stat3
T2622 4869-4878 VBG denotes signaling
T2623 4879-4887 NNS denotes pathways
T2624 4888-4891 VBP denotes are
T2625 4892-4900 VBN denotes required
T2626 4901-4904 IN denotes for
T2627 4905-4908 PRP$ denotes its
T2628 4909-4915 NN denotes growth
T2629 4916-4927 JJ denotes stimulatory
T2630 4928-4935 NNS denotes effects
T2631 4935-4936 . denotes .
R1343 T1774 T1775 compound Epstein-Barr,virus
R1345 T1775 T1779 nsubj virus,is
R1346 T1776 T1777 punct (,EBV
R1347 T1777 T1775 appos EBV,virus
R1348 T1778 T1775 punct ),virus
R1350 T1779 T1779 ROOT is,is
R1351 T1780 T1782 det a,γ-herpesvirus
R1353 T1781 T1782 amod ubiquitous,γ-herpesvirus
R1355 T1782 T1779 attr γ-herpesvirus,is
R1356 T1783 T1784 nsubj that,infects
R1358 T1784 T1782 relcl infects,γ-herpesvirus
R1360 T1785 T1784 dobj humans,infects
R1362 T1786 T1784 advmod predominantly,infects
R1364 T1787 T1784 prep at,infects
R1365 T1788 T1790 det an,age
R1366 T1789 T1790 amod early,age
R1367 T1790 T1787 pobj age,at
R1370 T1791 T1784 prep with,infects
R1372 T1792 T1794 amod greater,90
R1373 T1793 T1794 quantmod than,90
R1374 T1794 T1795 nummod 90,%
R1375 T1795 T1791 pobj %,with
R1376 T1796 T1795 prep of,%
R1377 T1797 T1799 det the,population
R1378 T1798 T1799 compound adult,population
R1379 T1799 T1796 pobj population,of
R1380 T1800 T1799 acl infected,population
R1382 T1801 T1800 prep with,infected
R1384 T1802 T1803 compound EBV,[
R1386 T1869 T1870 det this,ability
R1387 T1803 T1801 pobj [,with
R1388 T1870 T1877 nsubj ability,contributes
R1389 T1804 T1805 nummod 1,]
R1390 T1805 T1803 appos ],[
R1391 T1806 T1779 punct .,is
R1392 T1807 T1809 nsubjpass EBV,linked
R1393 T1808 T1809 auxpass is,linked
R1394 T1809 T1809 ROOT linked,linked
R1395 T1810 T1809 prep to,linked
R1396 T1871 T1872 aux to,affect
R1397 T1811 T1812 det the,development
R1398 T1812 T1810 pobj development,to
R1399 T1813 T1812 prep of,development
R1400 T1814 T1816 det both,lymphocyte
R1401 T1872 T1870 acl affect,ability
R1402 T1815 T1816 compound B,lymphocyte
R1403 T1816 T1813 pobj lymphocyte,of
R1404 T1817 T1816 cc and,lymphocyte
R1405 T1873 T1874 compound cell,growth
R1406 T1818 T1820 amod epithelial,malignancies
R1407 T1819 T1820 compound cell,malignancies
R1408 T1820 T1816 conj malignancies,lymphocyte
R1409 T1821 T1820 punct ",",malignancies
R1410 T1874 T1875 compound growth,regulation
R1411 T1822 T1820 prep including,malignancies
R1412 T1823 T1824 compound Burkitt,lymphoma
R1413 T1824 T1822 pobj lymphoma,including
R1414 T1825 T1824 punct ",",lymphoma
R1415 T1875 T1872 dobj regulation,affect
R1416 T1826 T1827 compound Hodgkin,disease
R1417 T1827 T1824 conj disease,lymphoma
R1418 T1828 T1829 punct (,HD
R1419 T1876 T1877 nsubj likely,contributes
R1420 T1829 T1827 appos HD,disease
R1421 T1830 T1827 punct ),disease
R1422 T1831 T1827 punct ",",disease
R1423 T1877 T1863 conj contributes,induces
R1424 T1832 T1827 cc and,disease
R1425 T1833 T1834 amod nasopharyngeal,carcinoma
R1426 T1834 T1827 conj carcinoma,disease
R1427 T1835 T1834 punct (,carcinoma
R1428 T1878 T1877 prep to,contributes
R1429 T1836 T1834 npadvmod NPC,carcinoma
R1430 T1837 T1834 punct ),carcinoma
R1431 T1838 T1834 punct ",",carcinoma
R1432 T1879 T1880 det the,development
R1433 T1880 T1878 pobj development,to
R1434 T1839 T1834 cc and,carcinoma
R1435 T1840 T1834 conj cancers,carcinoma
R1436 T1881 T1880 prep of,development
R1437 T1841 T1840 acl linked,cancers
R1438 T1842 T1841 prep to,linked
R1439 T1843 T1842 pobj immunosuppression,to
R1440 T1882 T1881 pobj cancer,of
R1441 T1844 T1843 punct ",",immunosuppression
R1442 T1845 T1843 prep including,immunosuppression
R1443 T1846 T1847 amod post-transplant,lymphoma
R1444 T1847 T1845 pobj lymphoma,including
R1445 T1848 T1847 cc and,lymphoma
R1446 T1849 T1850 amod AIDS-associated,lymphomas
R1447 T1883 T1877 punct .,contributes
R1448 T1850 T1847 conj lymphomas,lymphoma
R1449 T1851 T1853 compound [,]
R1450 T1852 T1853 compound "2,3",]
R1451 T1884 T1889 nsubj Many,expressed
R1452 T1853 T1847 conj ],lymphoma
R1453 T1854 T1809 punct .,linked
R1454 T1855 T1863 prep In,induces
R1455 T1856 T1857 amod vitro,infection
R1456 T1885 T1884 prep of,Many
R1457 T1857 T1855 pobj infection,In
R1458 T1858 T1857 prep of,infection
R1459 T1859 T1860 compound B,lymphocytes
R1460 T1886 T1888 det the,proteins
R1461 T1860 T1858 pobj lymphocytes,of
R1462 T1861 T1857 prep with,infection
R1463 T1862 T1861 pobj EBV,with
R1464 T1887 T1888 amod viral,proteins
R1465 T1863 T1863 ROOT induces,induces
R1466 T1864 T1866 amod permanent,transformation
R1467 T1865 T1866 compound growth,transformation
R1468 T1866 T1863 dobj transformation,induces
R1469 T1888 T1885 pobj proteins,of
R1470 T1867 T1863 punct ",",induces
R1471 T1889 T1904 nsubj expressed,have
R1472 T1890 T1889 prep in,expressed
R1473 T1868 T1863 cc and,induces
R1474 T1891 T1892 amod transformed,cells
R1475 T1892 T1890 pobj cells,in
R1476 T1893 T1889 punct ",",expressed
R1477 T1894 T1889 prep including,expressed
R1478 T1895 T1898 det the,antigens
R1479 T1900 T1902 amod latent,proteins
R1480 T1901 T1902 compound membrane,proteins
R1481 T1896 T1898 nmod EBV,antigens
R1482 T1902 T1898 conj proteins,antigens
R1483 T1903 T1889 punct ",",expressed
R1484 T1897 T1898 amod nuclear,antigens
R1485 T1904 T1904 ROOT have,have
R1486 T1905 T1906 amod profound,effects
R1487 T1906 T1904 dobj effects,have
R1488 T1898 T1894 pobj antigens,including
R1489 T1907 T1906 prep on,effects
R1490 T1908 T1909 compound cell,growth
R1491 T1909 T1910 compound growth,regulation
R1492 T1899 T1898 cc and,antigens
R1493 T1910 T1907 pobj regulation,on
R1494 T1911 T1904 cc and,have
R1495 T1912 T1913 auxpass are,required
R1496 T1913 T1904 conj required,have
R1497 T1914 T1913 prep for,required
R1498 T1915 T1917 compound EBV,infection
R1499 T1997 T1998 amod CD40,ligand
R1500 T1916 T1917 compound latent,infection
R1501 T1917 T1914 pobj infection,for
R1502 T1918 T1917 cc and,infection
R1503 T1919 T1920 compound B,cell
R1504 T1920 T1921 compound cell,transformation
R1505 T1921 T1917 conj transformation,infection
R1506 T1998 T1996 pobj ligand,with
R1507 T1922 T1924 nmod [,]
R1508 T1923 T1924 nummod 1,]
R1509 T1924 T1921 appos ],transformation
R1510 T1999 T2013 advcl expressed,acts
R1511 T1925 T1904 punct .,have
R1512 T1926 T1934 advmod Latent,considered
R1513 T1927 T1928 compound membrane,protein
R1514 T2000 T1999 prep on,expressed
R1515 T1928 T1934 nsubjpass protein,considered
R1516 T1929 T1928 nummod 1,protein
R1517 T1930 T1928 punct (,protein
R1518 T2001 T2003 amod activated,cells
R1519 T1931 T1928 appos LMP1,protein
R1520 T1932 T1928 punct ),protein
R1521 T1933 T1934 auxpass is,considered
R1522 T1934 T1934 ROOT considered,considered
R1523 T2002 T2003 compound T,cells
R1524 T1935 T1937 det the,oncoprotein
R1525 T1936 T1937 amod major,oncoprotein
R1526 T1937 T1934 oprd oncoprotein,considered
R1527 T2003 T2000 pobj cells,on
R1528 T1938 T1937 prep of,oncoprotein
R1529 T1939 T1938 pobj EBV,of
R1530 T1940 T1934 punct ",",considered
R1531 T2004 T2005 aux to,induce
R1532 T1941 T1943 mark as,transforms
R1533 T1942 T1943 nsubj it,transforms
R1534 T1943 T1934 advcl transforms,considered
R1535 T2005 T1999 xcomp induce,expressed
R1536 T1944 T1945 compound rodent,fibroblasts
R1537 T1945 T1943 dobj fibroblasts,transforms
R1538 T1946 T1943 prep to,transforms
R1539 T2006 T2008 compound B,activation
R1540 T1947 T1946 pobj tumorigenicity,to
R1541 T2007 T2008 compound cell,activation
R1542 T1948 T1947 prep in,tumorigenicity
R1543 T2008 T2005 dobj activation,induce
R1544 T1949 T1950 amod nude,mice
R1545 T1950 T1948 pobj mice,in
R1546 T1951 T1943 cc and,transforms
R1547 T2009 T2008 cc and,activation
R1548 T1952 T1953 auxpass is,expressed
R1549 T1953 T1943 conj expressed,transforms
R1550 T1954 T1953 prep in,expressed
R1551 T2010 T2008 conj differentiation,activation
R1552 T1955 T1954 pobj HD,in
R1553 T1956 T1955 punct ",",HD
R1554 T2011 T2013 punct ",",acts
R1555 T1957 T1955 conj NPC,HD
R1556 T1958 T1957 punct ",",NPC
R1557 T1959 T1957 cc and,NPC
R1558 T2012 T2013 nsubj LMP1,acts
R1559 T1960 T1961 compound immunosuppression-associated,tumors
R1560 T1961 T1957 conj tumors,NPC
R1561 T1962 T1943 conj [,transforms
R1562 T2013 T2013 ROOT acts,acts
R1563 T1963 T1962 nummod 4,[
R1564 T2014 T2013 prep as,acts
R1565 T1964 T1965 nummod 8,]
R1566 T2015 T2017 det a,signal
R1567 T1965 T1962 appos ],[
R1568 T1966 T1934 punct .,considered
R1569 T2016 T2017 amod constitutive,signal
R1570 T1967 T1972 prep In,mimics
R1571 T1968 T1969 compound B,lymphocytes
R1572 T2017 T2014 pobj signal,as
R1573 T1969 T1967 pobj lymphocytes,In
R1574 T1970 T1972 punct ",",mimics
R1575 T1971 T1972 nsubj LMP1,mimics
R1576 T2018 T2017 prep through,signal
R1577 T1972 T1972 ROOT mimics,mimics
R1578 T1973 T1972 dobj CD40,mimics
R1579 T1974 T1972 advcl signaling,mimics
R1580 T2019 T2020 amod ligand-independent,oligomerization
R1581 T1975 T1974 punct ",",signaling
R1582 T1976 T1972 cc and,mimics
R1583 T1977 T1978 det both,LMP1
R1584 T1978 T1981 nsubj LMP1,are
R1585 T2020 T2018 pobj oligomerization,through
R1586 T1979 T1978 cc and,LMP1
R1587 T1980 T1978 conj CD40,LMP1
R1588 T1981 T1972 conj are,mimics
R1589 T2021 T2013 punct .,acts
R1590 T1982 T1981 acomp essential,are
R1591 T1983 T1982 prep for,essential
R1592 T1984 T1987 amod EBV-mediated,transformation
R1593 T2022 T2025 nummod LMP1,interact
R1594 T1985 T1986 compound B,cell
R1595 T1986 T1987 compound cell,transformation
R1596 T1987 T1983 pobj transformation,for
R1597 T1988 T1983 dep [,for
R1598 T1989 T1988 nummod 9,[
R1599 T1990 T1991 nummod 11,]
R1600 T1991 T1988 appos ],[
R1601 T2023 T2022 cc and,LMP1
R1602 T1992 T1981 punct .,are
R1603 T1993 T1999 mark While,expressed
R1604 T1994 T1995 nummod CD40,interacts
R1605 T2024 T2022 conj CD40,LMP1
R1606 T1995 T1999 nsubj interacts,expressed
R1607 T1996 T1995 prep with,interacts
R1608 T2025 T2025 ROOT interact,interact
R1609 T2026 T2025 prep with,interact
R1610 T2027 T2031 det the,factor
R1611 T2028 T2031 amod same,factor
R1612 T2029 T2030 compound tumor,necrosis
R1613 T2094 T2095 punct (,PI3K
R1614 T2095 T2093 appos PI3K,kinase
R1615 T2096 T2091 punct ),phosphatidylinositol
R1616 T2030 T2031 compound necrosis,factor
R1617 T2097 T2098 compound /,Akt
R1618 T2098 T2099 nsubj Akt,signaling
R1619 T2099 T2090 advcl signaling,activates
R1620 T2031 T2026 pobj factor,with
R1621 T2100 T2099 cc and,signaling
R1622 T2101 T2105 mark that,required
R1623 T2032 T2060 nmod receptor,]
R1624 T2102 T2103 det this,activation
R1625 T2103 T2105 nsubjpass activation,required
R1626 T2033 T2034 amod associated,factors
R1627 T2104 T2105 auxpass is,required
R1628 T2034 T2032 appos factors,receptor
R1629 T2105 T2099 conj required,signaling
R1630 T2035 T2036 punct (,TRAFs
R1631 T2036 T2034 appos TRAFs,factors
R1632 T2106 T2105 prep for,required
R1633 T2107 T2108 amod LMP1-mediated,transformation
R1634 T2037 T2034 punct ),factors
R1635 T2108 T2106 pobj transformation,for
R1636 T2109 T2108 prep of,transformation
R1637 T2110 T2111 compound rodent,fibroblasts
R1638 T2038 T2032 acl leading,receptor
R1639 T2111 T2114 compound fibroblasts,]
R1640 T2112 T2114 compound [,]
R1641 T2039 T2038 prep to,leading
R1642 T2113 T2114 compound "5,19",]
R1643 T2114 T2109 pobj ],of
R1644 T2115 T2086 punct .,indicate
R1645 T2116 T2124 prep In,maintained
R1646 T2117 T2116 pobj vitro,In
R1647 T2118 T2124 punct ",",maintained
R1648 T2040 T2039 pobj activation,to
R1649 T2119 T2121 amod primary,cells
R1650 T2120 T2121 compound B,cells
R1651 T2121 T2124 nsubjpass cells,maintained
R1652 T2041 T2040 prep of,activation
R1653 T2122 T2124 aux can,maintained
R1654 T2123 T2124 auxpass be,maintained
R1655 T2042 T2041 pobj NFκB,of
R1656 T2124 T2124 ROOT maintained,maintained
R1657 T2125 T2124 agent by,maintained
R1658 T2126 T2127 compound CD40,ligation
R1659 T2043 T2042 punct ",",NFκB
R1660 T2127 T2125 pobj ligation,by
R1661 T2128 T2127 prep in,ligation
R1662 T2129 T2128 pobj combination,in
R1663 T2044 T2046 compound c-Jun,terminal
R1664 T2130 T2124 prep with,maintained
R1665 T2131 T2132 nummod IL4,treatment
R1666 T2045 T2046 compound N,terminal
R1667 T2132 T2130 pobj treatment,with
R1668 T2133 T2124 punct .,maintained
R1669 T2134 T2139 prep In,is
R1670 T2135 T2134 pobj vivo,In
R1671 T2046 T2047 compound terminal,kinase
R1672 T2136 T2139 punct ",",is
R1673 T2137 T2138 nsubj CD40,signaling
R1674 T2047 T2042 appos kinase,NFκB
R1675 T2138 T2139 nsubj signaling,is
R1676 T2139 T2139 ROOT is,is
R1677 T2140 T2139 acomp necessary,is
R1678 T2048 T2049 punct (,JNK
R1679 T2141 T2139 prep for,is
R1680 T2142 T2143 amod germinal,center
R1681 T2143 T2141 pobj center,for
R1682 T2144 T2145 punct (,GC
R1683 T2049 T2047 appos JNK,kinase
R1684 T2145 T2143 appos GC,center
R1685 T2146 T2145 punct ),GC
R1686 T2147 T2148 npadvmod formation,such
R1687 T2050 T2049 punct ),JNK
R1688 T2148 T2139 acomp such,is
R1689 T2149 T2156 mark that,are
R1690 T2150 T2151 nsubj mice,deficient
R1691 T2051 T2032 punct ",",receptor
R1692 T2151 T2156 nsubj deficient,are
R1693 T2152 T2151 prep for,deficient
R1694 T2153 T2152 pobj CD40,for
R1695 T2154 T2153 cc or,CD40
R1696 T2155 T2153 conj CD40L,CD40
R1697 T2052 T2032 cc and,receptor
R1698 T2053 T2054 nummod p38,MAPK
R1699 T2156 T2148 acl are,such
R1700 T2157 T2156 acomp unable,are
R1701 T2054 T2032 conj MAPK,receptor
R1702 T2158 T2159 aux to,form
R1703 T2159 T2157 xcomp form,unable
R1704 T2160 T2159 dobj GCs,form
R1705 T2055 T2032 conj signaling,receptor
R1706 T2161 T2159 prep in,form
R1707 T2162 T2161 pobj response,in
R1708 T2056 T2060 nsubj pathways,]
R1709 T2163 T2162 prep to,response
R1710 T2164 T2165 compound T,cell
R1711 T2165 T2163 pobj cell,to
R1712 T2057 T2060 dep [,]
R1713 T2166 T2167 amod dependent,antigens
R1714 T2167 T2159 dobj antigens,form
R1715 T2058 T2057 nummod 12,[
R1716 T2168 T2170 compound [,]
R1717 T2169 T2170 compound "20,21",]
R1718 T2170 T2167 appos ],antigens
R1719 T2059 T2060 nummod 16,]
R1720 T2171 T2139 punct .,is
R1721 T2172 T2175 preconj Both,proximal
R1722 T2173 T2175 det the,proximal
R1723 T2060 T2031 appos ],factor
R1724 T2061 T2060 punct .,]
R1725 T2174 T2175 compound membrane,proximal
R1726 T2175 T2199 nsubj proximal,is
R1727 T2062 T2066 nsubjpass Activation,required
R1728 T2176 T2175 cc and,proximal
R1729 T2177 T2179 amod distal,regions
R1730 T2178 T2179 amod cytoplasmic,regions
R1731 T2063 T2062 prep of,Activation
R1732 T2179 T2175 conj regions,proximal
R1733 T2180 T2179 prep of,regions
R1734 T2064 T2063 pobj NFκB,of
R1735 T2181 T2180 pobj CD40,of
R1736 T2182 T2190 mark that,are
R1737 T2183 T2190 nsubj bind,are
R1738 T2065 T2066 auxpass is,required
R1739 T2066 T2066 ROOT required,required
R1740 T2184 T2183 nummod TRAF6,bind
R1741 T2067 T2066 prep for,required
R1742 T2185 T2183 cc and,bind
R1743 T2186 T2183 conj TRAFs2/3/5,bind
R1744 T2068 T2070 amod EBV-induced,cell
R1745 T2187 T2183 punct ",",bind
R1746 T2188 T2183 advmod respectively,bind
R1747 T2189 T2190 punct ",",are
R1748 T2190 T2175 acl are,proximal
R1749 T2069 T2070 compound B,cell
R1750 T2191 T2190 acomp necessary,are
R1751 T2070 T2071 compound cell,transformation
R1752 T2192 T2190 prep for,are
R1753 T2071 T2067 pobj transformation,for
R1754 T2193 T2194 compound GC,formation
R1755 T2194 T2192 pobj formation,for
R1756 T2195 T2190 punct ",",are
R1757 T2072 T2071 cc and,transformation
R1758 T2196 T2190 cc but,are
R1759 T2197 T2198 det either,region
R1760 T2198 T2199 nsubj region,is
R1761 T2073 T2074 poss its,inhibition
R1762 T2199 T2199 ROOT is,is
R1763 T2200 T2199 acomp sufficient,is
R1764 T2201 T2202 aux to,induce
R1765 T2074 T2071 conj inhibition,transformation
R1766 T2202 T2200 xcomp induce,sufficient
R1767 T2203 T2206 amod extrafollicular,differentiation
R1768 T2204 T2205 compound B,cell
R1769 T2075 T2076 advmod rapidly,results
R1770 T2205 T2206 compound cell,differentiation
R1771 T2076 T2066 advcl results,required
R1772 T2206 T2202 dobj differentiation,induce
R1773 T2207 T2202 cc and,induce
R1774 T2208 T2202 conj restore,induce
R1775 T2209 T2212 amod low,production
R1776 T2077 T2076 prep in,results
R1777 T2210 T2211 compound affinity,antibody
R1778 T2211 T2212 compound antibody,production
R1779 T2212 T2208 dobj production,restore
R1780 T2078 T2079 compound cell,death
R1781 T2213 T2215 nmod [,]
R1782 T2214 T2215 nummod 22,]
R1783 T2215 T2212 nmod ],production
R1784 T2079 T2077 pobj death,in
R1785 T2216 T2199 punct .,is
R1786 T2217 T2221 advmod Functionally,rescue
R1787 T2218 T2221 punct ",",rescue
R1788 T2080 T2082 compound [,]
R1789 T2219 T2221 nsubj LMP1,rescue
R1790 T2220 T2221 aux can,rescue
R1791 T2221 T2221 ROOT rescue,rescue
R1792 T2081 T2082 compound "17,18",]
R1793 T2222 T2223 amod CD40-deficient,mice
R1794 T2223 T2221 dobj mice,rescue
R1795 T2224 T2221 cc and,rescue
R1796 T2225 T2221 conj restore,rescue
R1797 T2226 T2231 compound immunoglobulin,switching
R1798 T2227 T2230 punct (,class
R1799 T2082 T2076 appos ],results
R1800 T2228 T2230 nmod Ig,class
R1801 T2229 T2230 punct ),class
R1802 T2230 T2231 compound class,switching
R1803 T2231 T2225 dobj switching,restore
R1804 T2083 T2066 punct .,required
R1805 T2232 T2234 punct ",",likely
R1806 T2233 T2234 advmod most,likely
R1807 T2234 T2225 conj likely,restore
R1808 T2235 T2237 mark because,recruits
R1809 T2084 T2085 amod Recent,studies
R1810 T2236 T2237 nummod LMP1,recruits
R1811 T2237 T2234 advcl recruits,likely
R1812 T2238 T2240 amod similar,molecules
R1813 T2239 T2240 compound TRAF,molecules
R1814 T2085 T2086 nsubj studies,indicate
R1815 T2240 T2237 dobj molecules,recruits
R1816 T2241 T2237 punct ",",recruits
R1817 T2242 T2237 appos TRAFs,recruits
R1818 T2086 T2086 ROOT indicate,indicate
R1819 T2243 T2244 nummod 1/2/3,/
R1820 T2244 T2242 dobj /,TRAFs
R1821 T2245 T2244 nummod 5,/
R1822 T2087 T2090 mark that,activates
R1823 T2246 T2244 cc and,/
R1824 T2247 T2244 conj TRAF6,/
R1825 T2248 T2247 punct ",",TRAF6
R1826 T2088 T2090 nsubj LMP1,activates
R1827 T2249 T2244 prep through,/
R1828 T2250 T2253 det the,regions
R1829 T2251 T2253 amod C-terminal,regions
R1830 T2089 T2090 advmod also,activates
R1831 T2252 T2253 compound activation,regions
R1832 T2253 T2249 pobj regions,through
R1833 T2254 T2253 nummod 1,regions
R1834 T2090 T2086 ccomp activates,indicate
R1835 T2255 T2253 cc and,regions
R1836 T2256 T2257 nummod 2,domains
R1837 T2091 T2090 dobj phosphatidylinositol,activates
R1838 T2092 T2093 nummod 3,kinase
R1839 T2257 T2253 conj domains,regions
R1840 T2258 T2257 punct ",",domains
R1841 T2259 T2237 advmod respectively,recruits
R1842 T2093 T2091 appos kinase,phosphatidylinositol
R1843 T2260 T2221 punct .,rescue
R1844 T2261 T2264 advmod However,is
R1845 T2288 T2283 punct ",",studied
R1846 T2262 T2264 punct ",",is
R1847 T2263 T2264 nsubj LMP1,is
R1848 T2264 T2264 ROOT is,is
R1849 T2265 T2264 acomp unable,is
R1850 T2289 T2283 advmod however,studied
R1851 T2266 T2267 aux to,restore
R1852 T2267 T2265 xcomp restore,unable
R1853 T2268 T2269 compound affinity,maturation
R1854 T2269 T2267 dobj maturation,restore
R1855 T2290 T2283 punct ",",studied
R1856 T2270 T2269 cc and,maturation
R1857 T2271 T2272 compound GC,formation
R1858 T2291 T2292 advmod only,LMP1
R1859 T2272 T2269 conj formation,maturation
R1860 T2273 T2275 nmod [,]
R1861 T2274 T2275 nummod 23,]
R1862 T2292 T2293 nsubj LMP1,induces
R1863 T2275 T2264 dobj ],is
R1864 T2276 T2264 punct .,is
R1865 T2277 T2280 amod Several,proteins
R1866 T2293 T2283 conj induces,studied
R1867 T2278 T2280 nmod EBV,proteins
R1868 T2279 T2280 amod transforming,proteins
R1869 T2280 T2283 nsubjpass proteins,studied
R1870 T2294 T2295 compound tumor,development
R1871 T2281 T2283 aux have,studied
R1872 T2282 T2283 auxpass been,studied
R1873 T2295 T2293 dobj development,induces
R1874 T2283 T2283 ROOT studied,studied
R1875 T2284 T2283 prep in,studied
R1876 T2285 T2287 amod transgenic,models
R1877 T2296 T2297 advmod when,expressed
R1878 T2286 T2287 compound mouse,models
R1879 T2287 T2284 pobj models,in
R1880 T2297 T2293 advcl expressed,induces
R1881 T2298 T2297 prep under,expressed
R1882 T2299 T2300 det the,control
R1883 T2300 T2298 pobj control,under
R1884 T2354 T2350 punct ),mice
R1885 T2301 T2300 prep of,control
R1886 T2355 T2321 punct ",",express
R1887 T2356 T2321 advcl suggesting,express
R1888 T2357 T2359 mark that,contributes
R1889 T2302 T2306 det the,promoter
R1890 T2358 T2359 nsubj LMP1,contributes
R1891 T2359 T2356 ccomp contributes,suggesting
R1892 T2360 T2359 prep to,contributes
R1893 T2303 T2306 nmod Ig,promoter
R1894 T2361 T2362 compound tumor,development
R1895 T2362 T2360 pobj development,to
R1896 T2363 T2365 nmod [,]
R1897 T2364 T2365 nummod 26,]
R1898 T2365 T2362 appos ],development
R1899 T2366 T2321 punct .,express
R1900 T2367 T2369 det The,lymphomas
R1901 T2304 T2306 amod heavy,promoter
R1902 T2368 T2369 compound LMP1,lymphomas
R1903 T2369 T2371 nsubj lymphomas,rearranged
R1904 T2370 T2371 aux have,rearranged
R1905 T2305 T2306 compound chain,promoter
R1906 T2371 T2371 ROOT rearranged,rearranged
R1907 T2372 T2373 compound Ig,genes
R1908 T2373 T2371 dobj genes,rearranged
R1909 T2306 T2301 pobj promoter,of
R1910 T2374 T2371 cc and,rearranged
R1911 T2375 T2376 aux have,activated
R1912 T2376 T2371 conj activated,rearranged
R1913 T2307 T2306 cc and,promoter
R1914 T2377 T2376 dobj Akt,activated
R1915 T2378 T2377 punct ",",Akt
R1916 T2379 T2377 conj JNK,Akt
R1917 T2308 T2309 compound enhancer,[
R1918 T2380 T2379 punct ",",JNK
R1919 T2381 T2379 appos p38,JNK
R1920 T2382 T2379 punct ",",JNK
R1921 T2309 T2300 appos [,control
R1922 T2383 T2379 cc and,JNK
R1923 T2384 T2379 conj NFκB,JNK
R1924 T2310 T2309 nummod 24,[
R1925 T2311 T2312 nummod 26,]
R1926 T2312 T2300 appos ],control
R1927 T2385 T2376 punct ",",activated
R1928 T2386 T2376 prep with,activated
R1929 T2313 T2293 punct .,induces
R1930 T2387 T2388 amod specific,activation
R1931 T2388 T2386 pobj activation,with
R1932 T2389 T2388 prep of,activation
R1933 T2314 T2317 det The,mice
R1934 T2390 T2393 det the,member
R1935 T2391 T2393 compound NFκB,member
R1936 T2392 T2393 compound family,member
R1937 T2393 T2389 pobj member,of
R1938 T2315 T2317 compound LMP1,mice
R1939 T2394 T2395 compound cRel,[
R1940 T2395 T2376 dobj [,activated
R1941 T2316 T2317 compound transgenic,mice
R1942 T2396 T2397 nummod 27,]
R1943 T2397 T2395 appos ],[
R1944 T2398 T2371 punct .,rearranged
R1945 T2317 T2321 nsubj mice,express
R1946 T2399 T2411 prep In,characterized
R1947 T2400 T2401 det this,study
R1948 T2401 T2399 pobj study,In
R1949 T2402 T2411 punct ",",characterized
R1950 T2403 T2406 det the,lymphocytes
R1951 T2404 T2406 compound LMP1,lymphocytes
R1952 T2318 T2319 punct (,IgLMP1
R1953 T2405 T2406 compound transgenic,lymphocytes
R1954 T2406 T2411 nsubjpass lymphocytes,characterized
R1955 T2407 T2406 cc and,lymphocytes
R1956 T2408 T2406 conj lymphomas,lymphocytes
R1957 T2319 T2317 appos IgLMP1,mice
R1958 T2409 T2411 auxpass were,characterized
R1959 T2410 T2411 advmod further,characterized
R1960 T2411 T2411 ROOT characterized,characterized
R1961 T2320 T2317 punct ),mice
R1962 T2412 T2411 cc and,characterized
R1963 T2413 T2415 poss their,properties
R1964 T2414 T2415 compound growth,properties
R1965 T2321 T2321 ROOT express,express
R1966 T2415 T2419 nsubjpass properties,determined
R1967 T2416 T2415 prep in,properties
R1968 T2322 T2321 dobj LMP1,express
R1969 T2417 T2416 pobj vitro,in
R1970 T2323 T2322 prep in,LMP1
R1971 T2418 T2419 auxpass were,determined
R1972 T2324 T2325 compound B,lymphocytes
R1973 T2419 T2411 conj determined,characterized
R1974 T2420 T2419 punct .,determined
R1975 T2421 T2422 aux To,obtain
R1976 T2325 T2323 pobj lymphocytes,in
R1977 T2422 T2441 advcl obtain,inoculated
R1978 T2423 T2424 amod pure,populations
R1979 T2424 T2422 dobj populations,obtain
R1980 T2326 T2321 punct ",",express
R1981 T2425 T2424 prep of,populations
R1982 T2426 T2427 amod malignant,lymphocytes
R1983 T2327 T2321 cc and,express
R1984 T2427 T2425 pobj lymphocytes,of
R1985 T2428 T2422 cc and,obtain
R1986 T2328 T2336 prep in,develops
R1987 T2429 T2430 aux to,enable
R1988 T2430 T2422 conj enable,obtain
R1989 T2431 T2432 advmod more,detailed
R1990 T2329 T2328 pobj mice,in
R1991 T2432 T2434 amod detailed,analyses
R1992 T2433 T2434 compound biochemical,analyses
R1993 T2434 T2430 dobj analyses,enable
R1994 T2330 T2336 advcl older,develops
R1995 T2435 T2434 punct ",",analyses
R1996 T2436 T2434 conj examples,analyses
R1997 T2437 T2434 prep of,analyses
R1998 T2438 T2439 amod primary,lymphomas
R1999 T2439 T2437 pobj lymphomas,of
R2000 T2440 T2441 auxpass were,inoculated
R2001 T2331 T2336 prep than,develops
R2002 T2441 T2441 ROOT inoculated,inoculated
R2003 T2442 T2441 cc and,inoculated
R2004 T2443 T2441 conj passaged,inoculated
R2005 T2332 T2333 nummod 12,mo
R2006 T2444 T2443 prep in,passaged
R2007 T2445 T2446 compound SCID,mice
R2008 T2446 T2444 pobj mice,in
R2009 T2333 T2331 pobj mo,than
R2010 T2447 T2441 punct .,inoculated
R2011 T2448 T2453 advmod Interestingly,restricted
R2012 T2449 T2453 punct ",",restricted
R2013 T2334 T2336 punct ",",develops
R2014 T2450 T2451 compound lymphoma,development
R2015 T2335 T2336 nsubj lymphoma,develops
R2016 T2336 T2321 conj develops,express
R2017 T2451 T2453 nsubjpass development,restricted
R2018 T2337 T2336 prep with,develops
R2019 T2338 T2339 amod increased,incidence
R2020 T2452 T2453 auxpass was,restricted
R2021 T2339 T2337 pobj incidence,with
R2022 T2453 T2453 ROOT restricted,restricted
R2023 T2454 T2453 prep to,restricted
R2024 T2340 T2339 punct (,incidence
R2025 T2455 T2456 amod B-1a,lymphocytes
R2026 T2456 T2454 pobj lymphocytes,to
R2027 T2457 T2456 punct ",",lymphocytes
R2028 T2341 T2342 nummod 40,%
R2029 T2458 T2460 det a,population
R2030 T2459 T2460 amod self-replenishing,population
R2031 T2460 T2453 dobj population,restricted
R2032 T2342 T2339 appos %,incidence
R2033 T2461 T2460 prep of,population
R2034 T2462 T2461 pobj cells,of
R2035 T2343 T2344 nummod 50,%
R2036 T2463 T2464 nsubj that,are
R2037 T2464 T2462 relcl are,cells
R2038 T2465 T2464 acomp prone,are
R2039 T2344 T2339 appos %,incidence
R2040 T2466 T2467 aux to,malignancy
R2041 T2467 T2465 xcomp malignancy,prone
R2042 T2468 T2470 compound [,]
R2043 T2345 T2336 punct ),develops
R2044 T2469 T2470 compound "28,29",]
R2045 T2470 T2467 dobj ],malignancy
R2046 T2471 T2453 punct .,restricted
R2047 T2472 T2474 nummod LMP1,lymphocytes
R2048 T2473 T2474 amod transgenic,lymphocytes
R2049 T2474 T2476 nsubj lymphocytes,increased
R2050 T2346 T2321 prep compared,express
R2051 T2475 T2476 aux had,increased
R2052 T2476 T2476 ROOT increased,increased
R2053 T2477 T2476 dobj viability,increased
R2054 T2347 T2346 prep to,compared
R2055 T2478 T2476 prep in,increased
R2056 T2479 T2481 amod vitro,viability
R2057 T2480 T2479 cc and,vitro
R2058 T2348 T2350 amod wild-type,mice
R2059 T2481 T2478 pobj viability,in
R2060 T2349 T2350 compound control,mice
R2061 T2350 T2347 pobj mice,to
R2062 T2482 T2483 auxpass was,increased
R2063 T2483 T2476 conj increased,increased
R2064 T2484 T2483 agent by,increased
R2065 T2351 T2350 punct (,mice
R2066 T2485 T2486 det the,addition
R2067 T2486 T2484 pobj addition,by
R2068 T2487 T2486 prep of,addition
R2069 T2352 T2353 nummod 11,%
R2070 T2488 T2487 pobj IL4,of
R2071 T2489 T2476 punct .,increased
R2072 T2490 T2500 prep In,were
R2073 T2353 T2350 appos %,mice
R2074 T2491 T2490 pobj contrast,In
R2075 T2492 T2500 punct ",",were
R2076 T2548 T2547 punct ",",NFκB
R2077 T2493 T2494 preconj both,LMP1-positive
R2078 T2494 T2499 amod LMP1-positive,cells
R2079 T2495 T2494 cc and,LMP1-positive
R2080 T2496 T2497 punct -,negative
R2081 T2549 T2547 cc and,NFκB
R2082 T2497 T2494 conj negative,LMP1-positive
R2083 T2550 T2552 amod Stat3,pathways
R2084 T2498 T2499 compound lymphoma,cells
R2085 T2499 T2500 nsubj cells,were
R2086 T2500 T2500 ROOT were,were
R2087 T2551 T2552 compound signaling,pathways
R2088 T2501 T2500 acomp independent,were
R2089 T2502 T2501 prep of,independent
R2090 T2552 T2553 nsubj pathways,blocked
R2091 T2503 T2504 nummod IL4,co-stimulation
R2092 T2504 T2502 pobj co-stimulation,of
R2093 T2505 T2504 prep for,co-stimulation
R2094 T2553 T2553 ROOT blocked,blocked
R2095 T2506 T2505 pobj survival,for
R2096 T2507 T2506 cc and,survival
R2097 T2554 T2556 det the,growth
R2098 T2508 T2506 conj proliferation,survival
R2099 T2509 T2500 prep in,were
R2100 T2510 T2509 pobj vitro,in
R2101 T2511 T2500 prep with,were
R2102 T2512 T2514 det a,absence
R2103 T2513 T2514 amod complete,absence
R2104 T2555 T2556 amod enhanced,growth
R2105 T2514 T2511 pobj absence,with
R2106 T2515 T2514 prep of,absence
R2107 T2516 T2517 amod activated,Stat6
R2108 T2556 T2553 dobj growth,blocked
R2109 T2517 T2515 pobj Stat6,of
R2110 T2518 T2517 punct ",",Stat6
R2111 T2519 T2521 det the,target
R2112 T2520 T2521 compound IL4,target
R2113 T2557 T2556 prep of,growth
R2114 T2521 T2517 appos target,Stat6
R2115 T2522 T2500 punct .,were
R2116 T2558 T2563 det both,lymphocytes
R2117 T2523 T2524 det The,lymphomas
R2118 T2524 T2527 nsubjpass lymphomas,distinguished
R2119 T2525 T2527 auxpass were,distinguished
R2120 T2526 T2527 advmod also,distinguished
R2121 T2559 T2563 nummod LMP1,lymphocytes
R2122 T2527 T2527 ROOT distinguished,distinguished
R2123 T2528 T2527 agent by,distinguished
R2124 T2529 T2530 amod constitutive,activation
R2125 T2560 T2563 nmod transgenic,lymphocytes
R2126 T2530 T2528 pobj activation,by
R2127 T2531 T2530 prep of,activation
R2128 T2532 T2531 pobj Stat3,of
R2129 T2561 T2560 cc and,transgenic
R2130 T2533 T2530 cc and,activation
R2131 T2534 T2530 conj deregulation,activation
R2132 T2535 T2530 prep of,activation
R2133 T2562 T2560 conj malignant,transgenic
R2134 T2536 T2540 det the,pathway
R2135 T2537 T2539 compound Rb,cycle
R2136 T2538 T2539 compound cell,cycle
R2137 T2563 T2557 pobj lymphocytes,of
R2138 T2539 T2540 compound cycle,pathway
R2139 T2540 T2535 pobj pathway,of
R2140 T2541 T2527 punct .,distinguished
R2141 T2564 T2553 punct ",",blocked
R2142 T2542 T2552 nmod Inhibition,pathways
R2143 T2543 T2542 prep of,Inhibition
R2144 T2544 T2545 det the,PI3K/Akt
R2145 T2565 T2553 advcl suggesting,blocked
R2146 T2566 T2570 mark that,required
R2147 T2545 T2543 pobj PI3K/Akt,of
R2148 T2546 T2545 punct ",",PI3K/Akt
R2149 T2547 T2545 conj NFκB,PI3K/Akt
R2150 T2567 T2568 det these,pathways
R2151 T2568 T2570 nsubjpass pathways,required
R2152 T2569 T2570 auxpass are,required
R2153 T2579 T2580 aux to,be
R2154 T2580 T2578 xcomp be,appear
R2155 T2570 T2565 ccomp required,suggesting
R2156 T2581 T2583 det the,targets
R2157 T2582 T2583 amod same,targets
R2158 T2583 T2580 attr targets,be
R2159 T2571 T2570 prep for,required
R2160 T2584 T2586 nsubjpass that,deregulated
R2161 T2585 T2586 auxpass are,deregulated
R2162 T2572 T2573 poss their,growth
R2163 T2586 T2583 relcl deregulated,targets
R2164 T2587 T2586 prep in,deregulated
R2165 T2588 T2590 amod wild-type,lymphomas
R2166 T2573 T2571 pobj growth,for
R2167 T2589 T2590 compound B-1a,lymphomas
R2168 T2590 T2587 pobj lymphomas,in
R2169 T2591 T2592 nsubj that,arise
R2170 T2592 T2590 relcl arise,lymphomas
R2171 T2574 T2573 cc and,growth
R2172 T2593 T2592 advmod spontaneously,arise
R2173 T2594 T2592 prep through,arise
R2174 T2595 T2596 compound age,predisposition
R2175 T2575 T2573 conj survival,growth
R2176 T2596 T2594 pobj predisposition,through
R2177 T2597 T2578 punct .,appear
R2178 T2576 T2553 punct .,blocked
R2179 T2598 T2599 det This,study
R2180 T2599 T2600 nsubj study,reveals
R2181 T2600 T2600 ROOT reveals,reveals
R2182 T2601 T2603 mark that,promotes
R2183 T2602 T2603 nsubj LMP1,promotes
R2184 T2603 T2600 ccomp promotes,reveals
R2185 T2577 T2578 nsubj These,appear
R2186 T2604 T2603 dobj malignancy,promotes
R2187 T2605 T2603 prep in,promotes
R2188 T2606 T2605 pobj cells,in
R2189 T2578 T2578 ROOT appear,appear
R2190 T2607 T2606 prep with,cells
R2191 T2608 T2610 det the,ability
R2192 T2609 T2610 amod inherent,ability
R2194 T2610 T2607 pobj ability,with
R2195 T2611 T2612 aux to,proliferate
R2196 T2612 T2610 acl proliferate,ability
R2197 T2613 T2603 cc and,promotes
R2198 T2614 T2625 mark that,required
R2199 T2615 T2616 det the,Akt
R2200 T2616 T2623 nmod Akt,pathways
R2201 T2617 T2616 punct ",",Akt
R2202 T2618 T2616 conj NFκB,Akt
R2203 T2619 T2618 punct ",",NFκB
R2204 T2620 T2618 cc and,NFκB
R2205 T2621 T2623 amod Stat3,pathways
R2206 T2622 T2623 compound signaling,pathways
R2207 T2623 T2625 nsubjpass pathways,required
R2208 T2624 T2625 auxpass are,required
R2209 T2625 T2603 conj required,promotes
R2210 T2626 T2625 prep for,required
R2211 T2627 T2630 poss its,effects
R2212 T2628 T2630 nmod growth,effects
R2213 T2629 T2630 amod stimulatory,effects
R2214 T2630 T2626 pobj effects,for
R2215 T2631 T2600 punct .,reveals

UBERON-AE

Id Subject Object Predicate Lexical cue
T687 2113-2128 http://purl.obolibrary.org/obo/UBERON_0010754 denotes germinal center

GO-BP

Id Subject Object Predicate Lexical cue
T807 114-117 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T808 4716-4719 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T809 208-219 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T810 636-647 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T811 2982-2993 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T812 3312-3323 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T813 3821-3832 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T814 537-543 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T815 592-598 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T816 813-819 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T817 3578-3584 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T818 4465-4471 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T819 4577-4583 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T820 4909-4915 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T821 587-598 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T822 808-819 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T823 587-609 http://purl.obolibrary.org/obo/GO_0030308 denotes cell growth regulation
T824 808-830 http://purl.obolibrary.org/obo/GO_0030308 denotes cell growth regulation
T825 587-609 http://purl.obolibrary.org/obo/GO_0061387 denotes cell growth regulation
T826 808-830 http://purl.obolibrary.org/obo/GO_0061387 denotes cell growth regulation
T827 587-609 http://purl.obolibrary.org/obo/GO_0061388 denotes cell growth regulation
T828 808-830 http://purl.obolibrary.org/obo/GO_0061388 denotes cell growth regulation
T829 587-609 http://purl.obolibrary.org/obo/GO_0051513 denotes cell growth regulation
T830 808-830 http://purl.obolibrary.org/obo/GO_0051513 denotes cell growth regulation
T831 587-609 http://purl.obolibrary.org/obo/GO_0051510 denotes cell growth regulation
T832 808-830 http://purl.obolibrary.org/obo/GO_0051510 denotes cell growth regulation
T833 587-609 http://purl.obolibrary.org/obo/GO_0051516 denotes cell growth regulation
T834 808-830 http://purl.obolibrary.org/obo/GO_0051516 denotes cell growth regulation
T853 1335-1370 http://purl.obolibrary.org/obo/GO_0045600 denotes cell activation and differentiation
T854 1494-1502 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T855 1494-1502 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T856 1756-1766 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T857 1494-1502 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T858 1494-1502 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T859 1602-1605 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T860 3398-3401 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T861 1612-1615 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T862 1616-1620 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T863 1612-1630 http://purl.obolibrary.org/obo/GO_0032872 denotes p38 MAPK signaling
T864 1612-1630 http://purl.obolibrary.org/obo/GO_0051403 denotes p38 MAPK signaling
T865 1616-1630 http://purl.obolibrary.org/obo/GO_0000165 denotes MAPK signaling
T866 1621-1639 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T867 4425-4443 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T868 4869-4887 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T869 1761-1766 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T870 1815-1854 http://purl.obolibrary.org/obo/GO_0043552 denotes activates phosphatidylinositol 3 kinase
T871 1856-1860 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T872 4399-4403 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T873 2134-2143 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T874 2393-2402 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T875 2853-2862 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T876 2464-2484 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T877 2510-2529 http://purl.obolibrary.org/obo/GO_0002377 denotes antibody production
T878 2618-2633 http://purl.obolibrary.org/obo/GO_0045190 denotes class switching
T879 4361-4371 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T835 599-609 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T836 820-830 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T837 1159-1168 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T838 1621-1630 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T839 1866-1875 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T840 2086-2095 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T841 4425-4434 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T842 4869-4878 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T843 1335-1350 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T844 1335-1370 http://purl.obolibrary.org/obo/GO_0014040 denotes cell activation and differentiation
T845 1335-1370 http://purl.obolibrary.org/obo/GO_0031287 denotes cell activation and differentiation
T846 1335-1370 http://purl.obolibrary.org/obo/GO_0045594 denotes cell activation and differentiation
T847 1335-1370 http://purl.obolibrary.org/obo/GO_0045606 denotes cell activation and differentiation
T848 1335-1370 http://purl.obolibrary.org/obo/GO_0045690 denotes cell activation and differentiation
T849 1335-1370 http://purl.obolibrary.org/obo/GO_1902107 denotes cell activation and differentiation
T850 1335-1370 http://purl.obolibrary.org/obo/GO_1902913 denotes cell activation and differentiation
T851 1335-1370 http://purl.obolibrary.org/obo/GO_0046534 denotes cell activation and differentiation
T852 1335-1370 http://purl.obolibrary.org/obo/GO_0045597 denotes cell activation and differentiation

GO-MF

Id Subject Object Predicate Lexical cue
T2659 1285-1291 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T2660 1415-1421 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T2661 1602-1605 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T2662 3398-3401 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T2663 1612-1615 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T2664 1616-1620 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T2665 1856-1860 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T2666 4399-4403 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T2667 2510-2518 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T2668 2598-2612 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin

GO-CC

Id Subject Object Predicate Lexical cue
T2669 256-260 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2670 587-591 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2671 808-812 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2672 879-883 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2673 1226-1230 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2674 1335-1339 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2675 1698-1702 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2676 1756-1760 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2677 2227-2231 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2678 2464-2468 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2679 4361-4365 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2680 4788-4793 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2681 355-358 http://purl.obolibrary.org/obo/GO_0005643 denotes NPC
T2682 1072-1075 http://purl.obolibrary.org/obo/GO_0005643 denotes NPC
T2683 764-772 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T2684 911-919 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T2685 2269-2277 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T2686 2510-2518 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T2687 2510-2518 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody

sentences

Id Subject Object Predicate Lexical cue
T780 13-186 Sentence denotes Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus that infects humans predominantly at an early age with greater than 90% of the adult population infected with EBV [1].
T781 187-473 Sentence denotes EBV is linked to the development of both B lymphocyte and epithelial cell malignancies, including Burkitt lymphoma, Hodgkin disease (HD), and nasopharyngeal carcinoma (NPC), and cancers linked to immunosuppression, including post-transplant lymphoma and AIDS-associated lymphomas [2,3].
T782 474-658 Sentence denotes In vitro infection of B lymphocytes with EBV induces permanent growth transformation, and this ability to affect cell growth regulation likely contributes to the development of cancer.
T783 659-903 Sentence denotes Many of the viral proteins expressed in transformed cells, including the EBV nuclear antigens and latent membrane proteins, have profound effects on cell growth regulation and are required for EBV latent infection and B cell transformation [1].
T784 904-1123 Sentence denotes Latent membrane protein 1 (LMP1) is considered the major oncoprotein of EBV, as it transforms rodent fibroblasts to tumorigenicity in nude mice and is expressed in HD, NPC, and immunosuppression-associated tumors [4–8].
T785 1124-1253 Sentence denotes In B lymphocytes, LMP1 mimics CD40 signaling, and both LMP1 and CD40 are essential for EBV-mediated B cell transformation [9–11].
T786 1254-1450 Sentence denotes While CD40 interacts with CD40 ligand expressed on activated T cells to induce B cell activation and differentiation, LMP1 acts as a constitutive signal through ligand-independent oligomerization.
T787 1451-1648 Sentence denotes LMP1 and CD40 interact with the same tumor necrosis factor receptor–associated factors (TRAFs) leading to activation of NFκB, c-Jun N terminal kinase (JNK), and p38 MAPK signaling pathways [12–16].
T788 1649-1775 Sentence denotes Activation of NFκB is required for EBV-induced B cell transformation and its inhibition rapidly results in cell death [17,18].
T789 1776-1975 Sentence denotes Recent studies indicate that LMP1 also activates phosphatidylinositol 3 kinase (PI3K)/Akt signaling and that this activation is required for LMP1-mediated transformation of rodent fibroblasts [5,19].
T790 1976-2071 Sentence denotes In vitro, primary B cells can be maintained by CD40 ligation in combination with IL4 treatment.
T791 2072-2259 Sentence denotes In vivo, CD40 signaling is necessary for germinal center (GC) formation such that mice deficient for CD40 or CD40L are unable to form GCs in response to T cell–dependent antigens [20,21].
T792 2260-2535 Sentence denotes Both the membrane proximal and distal cytoplasmic regions of CD40 that bind TRAF6 and TRAFs2/3/5, respectively, are necessary for GC formation, but either region is sufficient to induce extrafollicular B cell differentiation and restore low affinity antibody production [22].
T793 2536-2790 Sentence denotes Functionally, LMP1 can rescue CD40-deficient mice and restore immunoglobulin (Ig) class switching, most likely because LMP1 recruits similar TRAF molecules, TRAFs 1/2/3/5 and TRAF6, through the C-terminal activation regions 1 and 2 domains, respectively.
T794 2791-2868 Sentence denotes However, LMP1 is unable to restore affinity maturation and GC formation [23].
T795 2869-3079 Sentence denotes Several EBV transforming proteins have been studied in transgenic mouse models, however, only LMP1 induces tumor development when expressed under the control of the Ig heavy chain promoter and enhancer [24–26].
T796 3080-3329 Sentence denotes The LMP1 transgenic mice (IgLMP1) express LMP1 in B lymphocytes, and in mice older than 12 mo, lymphoma develops with increased incidence (40%–50%) compared to wild-type control mice (11%), suggesting that LMP1 contributes to tumor development [26].
T797 3330-3479 Sentence denotes The LMP1 lymphomas have rearranged Ig genes and have activated Akt, JNK, p38, and NFκB, with specific activation of the NFκB family member cRel [27].
T798 3480-3621 Sentence denotes In this study, the LMP1 transgenic lymphocytes and lymphomas were further characterized and their growth properties in vitro were determined.
T799 3622-3796 Sentence denotes To obtain pure populations of malignant lymphocytes and to enable more detailed biochemical analyses, examples of primary lymphomas were inoculated and passaged in SCID mice.
T800 3797-3946 Sentence denotes Interestingly, lymphoma development was restricted to B-1a lymphocytes, a self-replenishing population of cells that are prone to malignancy [28,29].
T801 3947-4059 Sentence denotes LMP1 transgenic lymphocytes had increased viability in vitro and viability was increased by the addition of IL4.
T802 4060-4259 Sentence denotes In contrast, both LMP1-positive and -negative lymphoma cells were independent of IL4 co-stimulation for survival and proliferation in vitro with a complete absence of activated Stat6, the IL4 target.
T803 4260-4380 Sentence denotes The lymphomas were also distinguished by constitutive activation of Stat3 and deregulation of the Rb cell cycle pathway.
T804 4381-4597 Sentence denotes Inhibition of the PI3K/Akt, NFκB, and Stat3 signaling pathways blocked the enhanced growth of both LMP1 transgenic and malignant lymphocytes, suggesting that these pathways are required for their growth and survival.
T805 4598-4735 Sentence denotes These appear to be the same targets that are deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition.
T806 4736-4936 Sentence denotes This study reveals that LMP1 promotes malignancy in cells with the inherent ability to proliferate and that the Akt, NFκB, and Stat3 signaling pathways are required for its growth stimulatory effects.
T16 0-12 Sentence denotes Introduction
T17 13-186 Sentence denotes Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus that infects humans predominantly at an early age with greater than 90% of the adult population infected with EBV [1].
T18 187-473 Sentence denotes EBV is linked to the development of both B lymphocyte and epithelial cell malignancies, including Burkitt lymphoma, Hodgkin disease (HD), and nasopharyngeal carcinoma (NPC), and cancers linked to immunosuppression, including post-transplant lymphoma and AIDS-associated lymphomas [2,3].
T19 474-658 Sentence denotes In vitro infection of B lymphocytes with EBV induces permanent growth transformation, and this ability to affect cell growth regulation likely contributes to the development of cancer.
T20 659-903 Sentence denotes Many of the viral proteins expressed in transformed cells, including the EBV nuclear antigens and latent membrane proteins, have profound effects on cell growth regulation and are required for EBV latent infection and B cell transformation [1].
T21 904-1123 Sentence denotes Latent membrane protein 1 (LMP1) is considered the major oncoprotein of EBV, as it transforms rodent fibroblasts to tumorigenicity in nude mice and is expressed in HD, NPC, and immunosuppression-associated tumors [4–8].
T22 1124-1253 Sentence denotes In B lymphocytes, LMP1 mimics CD40 signaling, and both LMP1 and CD40 are essential for EBV-mediated B cell transformation [9–11].
T23 1254-1450 Sentence denotes While CD40 interacts with CD40 ligand expressed on activated T cells to induce B cell activation and differentiation, LMP1 acts as a constitutive signal through ligand-independent oligomerization.
T24 1451-1648 Sentence denotes LMP1 and CD40 interact with the same tumor necrosis factor receptor–associated factors (TRAFs) leading to activation of NFκB, c-Jun N terminal kinase (JNK), and p38 MAPK signaling pathways [12–16].
T25 1649-1775 Sentence denotes Activation of NFκB is required for EBV-induced B cell transformation and its inhibition rapidly results in cell death [17,18].
T26 1776-1975 Sentence denotes Recent studies indicate that LMP1 also activates phosphatidylinositol 3 kinase (PI3K)/Akt signaling and that this activation is required for LMP1-mediated transformation of rodent fibroblasts [5,19].
T27 1976-2071 Sentence denotes In vitro, primary B cells can be maintained by CD40 ligation in combination with IL4 treatment.
T28 2072-2259 Sentence denotes In vivo, CD40 signaling is necessary for germinal center (GC) formation such that mice deficient for CD40 or CD40L are unable to form GCs in response to T cell–dependent antigens [20,21].
T29 2260-2535 Sentence denotes Both the membrane proximal and distal cytoplasmic regions of CD40 that bind TRAF6 and TRAFs2/3/5, respectively, are necessary for GC formation, but either region is sufficient to induce extrafollicular B cell differentiation and restore low affinity antibody production [22].
T30 2536-2790 Sentence denotes Functionally, LMP1 can rescue CD40-deficient mice and restore immunoglobulin (Ig) class switching, most likely because LMP1 recruits similar TRAF molecules, TRAFs 1/2/3/5 and TRAF6, through the C-terminal activation regions 1 and 2 domains, respectively.
T31 2791-2868 Sentence denotes However, LMP1 is unable to restore affinity maturation and GC formation [23].
T32 2869-3079 Sentence denotes Several EBV transforming proteins have been studied in transgenic mouse models, however, only LMP1 induces tumor development when expressed under the control of the Ig heavy chain promoter and enhancer [24–26].
T33 3080-3329 Sentence denotes The LMP1 transgenic mice (IgLMP1) express LMP1 in B lymphocytes, and in mice older than 12 mo, lymphoma develops with increased incidence (40%–50%) compared to wild-type control mice (11%), suggesting that LMP1 contributes to tumor development [26].
T34 3330-3479 Sentence denotes The LMP1 lymphomas have rearranged Ig genes and have activated Akt, JNK, p38, and NFκB, with specific activation of the NFκB family member cRel [27].
T35 3480-3621 Sentence denotes In this study, the LMP1 transgenic lymphocytes and lymphomas were further characterized and their growth properties in vitro were determined.
T36 3622-3796 Sentence denotes To obtain pure populations of malignant lymphocytes and to enable more detailed biochemical analyses, examples of primary lymphomas were inoculated and passaged in SCID mice.
T37 3797-3946 Sentence denotes Interestingly, lymphoma development was restricted to B-1a lymphocytes, a self-replenishing population of cells that are prone to malignancy [28,29].
T38 3947-4059 Sentence denotes LMP1 transgenic lymphocytes had increased viability in vitro and viability was increased by the addition of IL4.
T39 4060-4259 Sentence denotes In contrast, both LMP1-positive and -negative lymphoma cells were independent of IL4 co-stimulation for survival and proliferation in vitro with a complete absence of activated Stat6, the IL4 target.
T40 4260-4380 Sentence denotes The lymphomas were also distinguished by constitutive activation of Stat3 and deregulation of the Rb cell cycle pathway.
T41 4381-4597 Sentence denotes Inhibition of the PI3K/Akt, NFκB, and Stat3 signaling pathways blocked the enhanced growth of both LMP1 transgenic and malignant lymphocytes, suggesting that these pathways are required for their growth and survival.
T42 4598-4735 Sentence denotes These appear to be the same targets that are deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition.
T43 4736-4936 Sentence denotes This study reveals that LMP1 promotes malignancy in cells with the inherent ability to proliferate and that the Akt, NFκB, and Stat3 signaling pathways are required for its growth stimulatory effects.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T2980 1188-1192 Protein denotes CD40
T2981 1260-1264 Protein denotes CD40
T2982 1265-1274 Binding denotes interacts
T2983 1280-1291 Protein denotes CD40 ligand
T2984 1292-1301 Gene_expression denotes expressed
T2985 1372-1376 Protein denotes LMP1
T2986 1434-1449 Binding denotes oligomerization
T2987 1451-1455 Protein denotes LMP1
T2988 1460-1464 Protein denotes CD40
T2989 1465-1473 Binding denotes interact
T2990 1465-1473 Binding denotes interact
T2991 1488-1509 Protein denotes tumor necrosis factor
T2992 1577-1582 Protein denotes c-Jun
T2993 1805-1809 Protein denotes LMP1
T2994 1862-1865 Protein denotes Akt
T2995 1917-1921 Protein denotes LMP1
T2996 2023-2027 Protein denotes CD40
T2997 2028-2036 Binding denotes ligation
T2998 2057-2060 Protein denotes IL4
T2999 2081-2085 Protein denotes CD40
T3000 2159-2168 Negative_regulation denotes deficient
T3001 2159-2168 Negative_regulation denotes deficient
T3002 2173-2177 Protein denotes CD40
T3003 2181-2186 Protein denotes CD40L
T3004 2269-2286 Entity denotes membrane proximal
T3005 2291-2317 Entity denotes distal cytoplasmic regions
T3006 2321-2325 Protein denotes CD40
T3007 2331-2335 Binding denotes bind
T3008 2331-2335 Binding denotes bind
T3009 2331-2335 Binding denotes bind
T3010 2331-2335 Binding denotes bind
T3011 2336-2341 Protein denotes TRAF6
T3012 2346-2352 Protein denotes TRAFs2
T3013 2353-2354 Protein denotes 3
T3014 2355-2356 Protein denotes 5
T3015 2550-2554 Protein denotes LMP1
T3016 2559-2565 Negative_regulation denotes rescue
T3017 2566-2570 Protein denotes CD40
T3018 2571-2580 Negative_regulation denotes deficient
T3019 2655-2659 Protein denotes LMP1
T3020 2660-2668 Binding denotes recruits
T3021 2660-2668 Binding denotes recruits
T3022 2660-2668 Binding denotes recruits
T3023 2660-2668 Binding denotes recruits
T3024 2660-2668 Binding denotes recruits
T3025 2693-2700 Protein denotes TRAFs 1
T3026 2701-2702 Protein denotes 2
T3027 2703-2704 Protein denotes 3
T3028 2705-2706 Protein denotes 5
T3029 2711-2716 Protein denotes TRAF6
T3030 2730-2761 Entity denotes C-terminal activation regions 1
T3031 2766-2775 Entity denotes 2 domains
T3032 2800-2804 Protein denotes LMP1
T3033 2963-2967 Protein denotes LMP1
T3034 2999-3008 Gene_expression denotes expressed
T3035 3009-3026 Positive_regulation denotes under the control
T3036 3084-3088 Protein denotes LMP1
T3037 3114-3121 Gene_expression denotes express
T3038 3122-3126 Protein denotes LMP1
T3039 3286-3290 Protein denotes LMP1
T3040 3334-3338 Protein denotes LMP1
T3041 3383-3392 Positive_regulation denotes activated
T3042 3393-3396 Protein denotes Akt
T3043 3432-3442 Positive_regulation denotes activation
T3044 3469-3473 Protein denotes cRel
T3045 3499-3503 Protein denotes LMP1
T3046 3947-3951 Protein denotes LMP1
T3047 4055-4058 Protein denotes IL4
T3048 4078-4082 Protein denotes LMP1
T3049 4141-4144 Protein denotes IL4
T3050 4216-4223 Negative_regulation denotes absence
T3051 4227-4236 Positive_regulation denotes activated
T3052 4237-4242 Protein denotes Stat6
T3053 4248-4251 Protein denotes IL4
T3054 4252-4258 Regulation denotes target
T3055 4314-4324 Positive_regulation denotes activation
T3056 4328-4333 Protein denotes Stat3
T3057 4358-4360 Protein denotes Rb
T3058 4404-4407 Protein denotes Akt
T3059 4419-4424 Protein denotes Stat3
T3060 4480-4484 Protein denotes LMP1
T3061 4643-4654 Regulation denotes deregulated true true
T3062 4643-4654 Regulation denotes deregulated true true
T3063 4760-4764 Protein denotes LMP1
T3064 4848-4851 Protein denotes Akt
T3065 4863-4868 Protein denotes Stat3
T2974 904-929 Protein denotes Latent membrane protein 1
T2975 931-935 Protein denotes LMP1
T2976 1055-1064 Gene_expression denotes expressed
T2977 1142-1146 Protein denotes LMP1
T2978 1154-1158 Protein denotes CD40
T2979 1179-1183 Protein denotes LMP1
R2354 T2974 T2976 themeOf Latent membrane protein 1,expressed
R2355 T2975 T2974 equivalentTo LMP1,Latent membrane protein 1
R2356 T2981 T2982 themeOf CD40,interacts
R2357 T2983 T2982 themeOf CD40 ligand,interacts
R2358 T2983 T2984 themeOf CD40 ligand,expressed
R2390 T3034 T3035 themeOf expressed,under the control
R2391 T3038 T3037 themeOf LMP1,express
R2392 T3042 T3041 themeOf Akt,activated
R2393 T3044 T3043 themeOf cRel,activation
R2394 T3051 T3050 themeOf activated,absence
R2395 T3052 T3051 themeOf Stat6,activated
R2396 T3052 T3054 themeOf Stat6,target
R2397 T3053 T3054 causeOf IL4,target
R2398 T3056 T3055 themeOf Stat3,activation
R2399 T3058 T3061 themeOf Akt,deregulated
R2400 T3059 T3062 themeOf Stat3,deregulated
R2359 T2985 T2986 themeOf LMP1,oligomerization
R2360 T2987 T2990 themeOf LMP1,interact
R2361 T2988 T2989 themeOf CD40,interact
R2362 T2996 T2997 themeOf CD40,ligation
R2363 T3002 T3001 themeOf CD40,deficient
R2364 T3003 T3000 themeOf CD40L,deficient
R2365 T3004 T3008 themeOf membrane proximal,bind
R2366 T3004 T3006 partOf membrane proximal,CD40
R2367 T3005 T3010 themeOf distal cytoplasmic regions,bind
R2368 T3005 T3006 partOf distal cytoplasmic regions,CD40
R2369 T3005 T3009 themeOf distal cytoplasmic regions,bind
R2370 T3005 T3007 themeOf distal cytoplasmic regions,bind
R2371 T3011 T3008 themeOf TRAF6,bind
R2372 T3012 T3010 themeOf TRAFs2,bind
R2373 T3013 T3009 themeOf 3,bind
R2374 T3014 T3007 themeOf 5,bind
R2375 T3017 T3018 themeOf CD40,deficient
R2376 T3018 T3016 themeOf deficient,rescue
R2377 T3025 T3021 themeOf TRAFs 1,recruits
R2378 T3026 T3024 themeOf 2,recruits
R2379 T3027 T3023 themeOf 3,recruits
R2380 T3028 T3020 themeOf 5,recruits
R2381 T3029 T3022 themeOf TRAF6,recruits
R2382 T3030 T3021 themeOf C-terminal activation regions 1,recruits
R2383 T3030 T3019 partOf C-terminal activation regions 1,LMP1
R2384 T3030 T3024 themeOf C-terminal activation regions 1,recruits
R2385 T3030 T3023 themeOf C-terminal activation regions 1,recruits
R2386 T3030 T3020 themeOf C-terminal activation regions 1,recruits
R2387 T3031 T3022 themeOf 2 domains,recruits
R2388 T3031 T3019 partOf 2 domains,LMP1
R2389 T3033 T3034 themeOf LMP1,expressed

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T2872 904-929 Protein denotes Latent membrane protein 1
T2873 931-935 Protein denotes LMP1
T2874 1055-1064 Gene_expression denotes expressed
T2875 1055-1064 Gene_expression denotes expressed
T2876 1142-1146 Protein denotes LMP1
T2877 1154-1158 Protein denotes CD40
T2878 1179-1183 Protein denotes LMP1
T2879 1188-1192 Protein denotes CD40
T2880 1260-1264 Protein denotes CD40
T2881 1280-1291 Protein denotes CD40 ligand
T2882 1372-1376 Protein denotes LMP1
T2883 1265-1274 Binding denotes interacts
T2884 1292-1301 Gene_expression denotes expressed
T2885 1434-1449 Binding denotes oligomerization
T2886 1451-1455 Protein denotes LMP1
T2887 1460-1473 Protein denotes CD40 interact
T2888 1488-1537 Protein denotes tumor necrosis factor receptor–associated factors
T2889 1539-1544 Protein denotes TRAFs
T2890 1571-1575 Protein denotes NFκB
T2891 1577-1600 Protein denotes c-Jun N terminal kinase
T2892 1602-1605 Protein denotes JNK
T2893 1612-1615 Protein denotes p38
T2894 1557-1567 Positive_regulation denotes activation
T2895 1557-1567 Positive_regulation denotes activation
T2896 1557-1567 Positive_regulation denotes activation
T2897 1663-1667 Protein denotes NFκB
T2898 1649-1659 Positive_regulation denotes Activation
T2899 1805-1809 Protein denotes LMP1
T2900 1825-1854 Protein denotes phosphatidylinositol 3 kinase
T2901 1856-1860 Protein denotes PI3K
T2902 1862-1865 Protein denotes Akt
T2903 1917-1921 Protein denotes LMP1
T2904 1815-1824 Positive_regulation denotes activates
T2905 1815-1824 Positive_regulation denotes activates
T2906 2023-2027 Protein denotes CD40
T2907 2057-2060 Protein denotes IL4
T2908 2028-2036 Binding denotes ligation
T2909 2081-2085 Protein denotes CD40
T2910 2173-2177 Protein denotes CD40
T2911 2181-2186 Protein denotes CD40L
T2912 2159-2168 Negative_regulation denotes deficient
T2913 2159-2168 Negative_regulation denotes deficient
T2914 2321-2325 Protein denotes CD40
T2915 2336-2341 Protein denotes TRAF6
T2916 2310-2317 Entity denotes regions
T2917 2331-2335 Binding denotes bind
T2918 2331-2335 Binding denotes bind
T2919 2550-2554 Protein denotes LMP1
T2920 2566-2570 Protein denotes CD40
T2921 2598-2612 Protein denotes immunoglobulin
T2922 2614-2616 Protein denotes Ig
T2923 2655-2659 Protein denotes LMP1
T2924 2711-2716 Protein denotes TRAF6
T2925 2571-2580 Negative_regulation denotes deficient
T2926 2618-2623 Entity denotes class
T2927 2624-2633 Binding denotes switching
T2928 2660-2668 Binding denotes recruits
T2929 2768-2775 Entity denotes domains
T2930 2590-2597 Negative_regulation denotes restore
T2931 2800-2804 Protein denotes LMP1
T2932 2963-2967 Protein denotes LMP1
T2933 3034-3057 Protein denotes Ig heavy chain promoter
T2934 3019-3026 Regulation denotes control
T2935 3084-3104 Protein denotes LMP1 transgenic mice
T2936 3106-3112 Protein denotes IgLMP1
T2937 3122-3126 Protein denotes LMP1
T2938 3286-3290 Protein denotes LMP1
T2939 3114-3121 Gene_expression denotes express
T2940 3114-3121 Gene_expression denotes express
T2941 3114-3121 Gene_expression denotes express
T2942 3334-3338 Protein denotes LMP1
T2943 3365-3373 Protein denotes Ig genes
T2944 3393-3396 Protein denotes Akt
T2945 3398-3401 Protein denotes JNK
T2946 3403-3406 Protein denotes p38
T2947 3412-3416 Protein denotes NFκB
T2948 3450-3461 Protein denotes NFκB family
T2949 3383-3392 Positive_regulation denotes activated
T2950 3383-3392 Positive_regulation denotes activated
T2951 3383-3392 Positive_regulation denotes activated
T2952 3432-3442 Positive_regulation denotes activation
T2953 3499-3503 Protein denotes LMP1
T2954 3947-3951 Protein denotes LMP1
T2955 4055-4058 Protein denotes IL4
T2956 4078-4082 Protein denotes LMP1
T2957 4141-4144 Protein denotes IL4
T2958 4237-4242 Protein denotes Stat6
T2959 4248-4258 Protein denotes IL4 target
T2960 4227-4236 Positive_regulation denotes activated
T2961 4216-4223 Negative_regulation denotes absence
T2962 4328-4333 Protein denotes Stat3
T2963 4358-4360 Protein denotes Rb
T2964 4314-4324 Positive_regulation denotes activation
T2965 4399-4403 Protein denotes PI3K
T2966 4404-4407 Protein denotes Akt
T2967 4409-4413 Protein denotes NFκB
T2968 4419-4424 Protein denotes Stat3
T2969 4480-4484 Protein denotes LMP1
T2970 4760-4764 Protein denotes LMP1
T2971 4848-4851 Protein denotes Akt
T2972 4853-4857 Protein denotes NFκB
T2973 4863-4868 Protein denotes Stat3
R2302 T2872 T2874 themeOf Latent membrane protein 1,expressed
R2304 T2873 T2875 themeOf LMP1,expressed
R2308 T2880 T2883 themeOf CD40,interacts
R2312 T2881 T2883 themeOf CD40 ligand,interacts
R2313 T2881 T2884 themeOf CD40 ligand,expressed
R2314 T2882 T2885 themeOf LMP1,oligomerization
R2315 T2890 T2894 themeOf NFκB,activation
R2316 T2891 T2895 themeOf c-Jun N terminal kinase,activation
R2317 T2892 T2896 themeOf JNK,activation
R2318 T2897 T2898 themeOf NFκB,Activation
R2338 T2937 T2941 themeOf LMP1,express
R2339 T2910 T2912 themeOf CD40,deficient
R2340 T2944 T2949 themeOf Akt,activated
R2341 T2945 T2950 themeOf JNK,activated
R2342 T2911 T2913 themeOf CD40L,deficient
R2343 T2946 T2951 themeOf p38,activated
R2344 T2948 T2952 themeOf NFκB family,activation
R2345 T2914 T2917 themeOf CD40,bind
R2346 T2914 T2918 themeOf CD40,bind
R2347 T2914 T2916 partOf CD40,regions
R2348 T2915 T2918 themeOf TRAF6,bind
R2349 T2916 T2917 Site regions,bind
R2350 T2958 T2960 themeOf Stat6,activated
R2351 T2960 T2961 themeOf activated,absence
R2352 T2962 T2964 themeOf Stat3,activation
R2353 T2916 T2918 Site regions,bind
R2319 T2919 T2930 causeOf LMP1,restore
R2320 T2920 T2925 themeOf CD40,deficient
R2321 T2921 T2927 themeOf immunoglobulin,switching
R2322 T2921 T2926 partOf immunoglobulin,class
R2323 T2922 T2926 partOf Ig,class
R2324 T2899 T2904 causeOf LMP1,activates
R2325 T2923 T2928 themeOf LMP1,recruits
R2326 T2923 T2929 partOf LMP1,domains
R2327 T2924 T2928 themeOf TRAF6,recruits
R2328 T2926 T2927 Site class,switching
R2329 T2926 T2928 Site class,recruits
R2330 T2927 T2930 themeOf switching,restore
R2331 T2899 T2905 causeOf LMP1,activates
R2332 T2900 T2904 themeOf phosphatidylinositol 3 kinase,activates
R2333 T2902 T2905 themeOf Akt,activates
R2334 T2933 T2934 themeOf Ig heavy chain promoter,control
R2335 T2906 T2908 themeOf CD40,ligation
R2336 T2935 T2939 themeOf LMP1 transgenic mice,express
R2337 T2936 T2940 themeOf IgLMP1,express

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T706 1577-1582 Protein denotes c-Jun
T707 1805-1809 Protein denotes LMP1
T708 1862-1865 Protein denotes Akt
T709 1917-1921 Protein denotes LMP1
T710 2023-2027 Protein denotes CD40
T711 2028-2036 Binding denotes ligation
T712 2057-2060 Protein denotes IL4
T713 2081-2085 Protein denotes CD40
T714 2159-2168 Negative_regulation denotes deficient
T715 2159-2168 Negative_regulation denotes deficient
T716 2173-2177 Protein denotes CD40
T717 2181-2186 Protein denotes CD40L
T718 2269-2286 Entity denotes membrane proximal
T719 2291-2317 Entity denotes distal cytoplasmic regions
T720 2321-2325 Protein denotes CD40
T721 2331-2335 Binding denotes bind
T722 2331-2335 Binding denotes bind
T723 2331-2335 Binding denotes bind
T724 2331-2335 Binding denotes bind
T725 2336-2341 Protein denotes TRAF6
T726 2346-2352 Protein denotes TRAFs2
T727 2353-2354 Protein denotes 3
T728 2355-2356 Protein denotes 5
T729 2550-2554 Protein denotes LMP1
T730 2559-2565 Negative_regulation denotes rescue
T731 2566-2570 Protein denotes CD40
T732 2571-2580 Negative_regulation denotes deficient
T733 2655-2659 Protein denotes LMP1
T734 2660-2668 Binding denotes recruits
T735 2660-2668 Binding denotes recruits
T736 2660-2668 Binding denotes recruits
T737 2660-2668 Binding denotes recruits
T738 2660-2668 Binding denotes recruits
T739 2693-2700 Protein denotes TRAFs 1
T740 2701-2702 Protein denotes 2
T741 2703-2704 Protein denotes 3
T742 2705-2706 Protein denotes 5
T743 2711-2716 Protein denotes TRAF6
T744 2730-2761 Entity denotes C-terminal activation regions 1
T745 2766-2775 Entity denotes 2 domains
T746 2800-2804 Protein denotes LMP1
T747 2963-2967 Protein denotes LMP1
T748 2999-3008 Gene_expression denotes expressed
T749 3009-3026 Positive_regulation denotes under the control
T750 3084-3088 Protein denotes LMP1
T751 3114-3121 Gene_expression denotes express
T752 3122-3126 Protein denotes LMP1
T753 3286-3290 Protein denotes LMP1
T754 3334-3338 Protein denotes LMP1
T755 3383-3392 Positive_regulation denotes activated
T756 3393-3396 Protein denotes Akt
T757 3432-3442 Positive_regulation denotes activation
T758 3469-3473 Protein denotes cRel
T759 3499-3503 Protein denotes LMP1
T760 3947-3951 Protein denotes LMP1
T761 4055-4058 Protein denotes IL4
T688 904-929 Protein denotes Latent membrane protein 1
T689 931-935 Protein denotes LMP1
T690 1055-1064 Gene_expression denotes expressed
T691 1142-1146 Protein denotes LMP1
T692 1154-1158 Protein denotes CD40
T693 1179-1183 Protein denotes LMP1
T694 1188-1192 Protein denotes CD40
T695 1260-1264 Protein denotes CD40
T696 1265-1274 Binding denotes interacts
T697 1280-1291 Protein denotes CD40 ligand
T698 1292-1301 Gene_expression denotes expressed
T699 1372-1376 Protein denotes LMP1
T700 1434-1449 Binding denotes oligomerization
T701 1451-1455 Protein denotes LMP1
T702 1460-1464 Protein denotes CD40
T703 1465-1473 Binding denotes interact
T704 1465-1473 Binding denotes interact
T705 1488-1509 Protein denotes tumor necrosis factor
T762 4078-4082 Protein denotes LMP1
T763 4141-4144 Protein denotes IL4
T764 4216-4223 Negative_regulation denotes absence
T765 4227-4236 Positive_regulation denotes activated
T766 4237-4242 Protein denotes Stat6
T767 4248-4251 Protein denotes IL4
T768 4252-4258 Regulation denotes target
T769 4314-4324 Positive_regulation denotes activation
T770 4328-4333 Protein denotes Stat3
T771 4358-4360 Protein denotes Rb
T772 4404-4407 Protein denotes Akt
T773 4419-4424 Protein denotes Stat3
T774 4480-4484 Protein denotes LMP1
T775 4643-4654 Regulation denotes deregulated true true
T776 4643-4654 Regulation denotes deregulated true true
T777 4760-4764 Protein denotes LMP1
T778 4848-4851 Protein denotes Akt
T779 4863-4868 Protein denotes Stat3
R497 T745 T733 partOf 2 domains,LMP1
R498 T747 T748 themeOf LMP1,expressed
R499 T748 T749 themeOf expressed,under the control
R500 T752 T751 themeOf LMP1,express
R468 T699 T700 themeOf LMP1,oligomerization
R469 T701 T704 themeOf LMP1,interact
R470 T702 T703 themeOf CD40,interact
R471 T710 T711 themeOf CD40,ligation
R472 T716 T715 themeOf CD40,deficient
R473 T717 T714 themeOf CD40L,deficient
R474 T718 T722 themeOf membrane proximal,bind
R475 T718 T720 partOf membrane proximal,CD40
R476 T719 T724 themeOf distal cytoplasmic regions,bind
R477 T719 T720 partOf distal cytoplasmic regions,CD40
R478 T719 T723 themeOf distal cytoplasmic regions,bind
R479 T719 T721 themeOf distal cytoplasmic regions,bind
R480 T725 T722 themeOf TRAF6,bind
R481 T726 T724 themeOf TRAFs2,bind
R482 T727 T723 themeOf 3,bind
R483 T728 T721 themeOf 5,bind
R484 T731 T732 themeOf CD40,deficient
R485 T732 T730 themeOf deficient,rescue
R486 T739 T735 themeOf TRAFs 1,recruits
R487 T740 T738 themeOf 2,recruits
R488 T741 T737 themeOf 3,recruits
R489 T742 T734 themeOf 5,recruits
R490 T743 T736 themeOf TRAF6,recruits
R491 T744 T735 themeOf C-terminal activation regions 1,recruits
R492 T744 T733 partOf C-terminal activation regions 1,LMP1
R493 T744 T738 themeOf C-terminal activation regions 1,recruits
R494 T744 T737 themeOf C-terminal activation regions 1,recruits
R495 T744 T734 themeOf C-terminal activation regions 1,recruits
R496 T745 T736 themeOf 2 domains,recruits
R463 T688 T690 themeOf Latent membrane protein 1,expressed
R464 T689 T688 equivalentTo LMP1,Latent membrane protein 1
R465 T695 T696 themeOf CD40,interacts
R466 T697 T696 themeOf CD40 ligand,interacts
R467 T697 T698 themeOf CD40 ligand,expressed
R501 T756 T755 themeOf Akt,activated
R502 T758 T757 themeOf cRel,activation
R503 T765 T764 themeOf activated,absence
R504 T766 T765 themeOf Stat6,activated
R505 T766 T768 themeOf Stat6,target
R506 T767 T768 causeOf IL4,target
R507 T770 T769 themeOf Stat3,activation
R508 T772 T775 themeOf Akt,deregulated
R509 T773 T776 themeOf Stat3,deregulated

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T1706 904-929 P03230 denotes Latent membrane protein 1
T1707 931-935 P03230 denotes LMP1
T1708 1142-1146 P03230 denotes LMP1
T1709 1154-1158 P25942 denotes CD40
T1710 1179-1183 P03230 denotes LMP1
T1711 1188-1192 P25942 denotes CD40
T1712 1260-1264 P25942 denotes CD40
T1713 1280-1284 P25942 denotes CD40
T1714 1280-1291 P29965 denotes CD40 ligand
T1715 1372-1376 P03230 denotes LMP1
T1716 1451-1455 P03230 denotes LMP1
T1717 1460-1464 P25942 denotes CD40
T1718 1488-1509 P01375 denotes tumor necrosis factor
T1719 1577-1582 P05412 denotes c-Jun
T1720 1579-1582 P05412 denotes Jun
T1721 1612-1615 O15264 denotes p38
T1722 1612-1615 Q15759 denotes p38
T1723 1612-1615 P53778 denotes p38
T1724 1612-1615 Q16539 denotes p38
T1725 1805-1809 P03230 denotes LMP1
T1726 1862-1865 P31751 denotes Akt
T1727 1862-1865 P31749 denotes Akt
T1728 1862-1865 Q9Y243 denotes Akt
T1729 1917-1921 P03230 denotes LMP1
T1730 2023-2027 P25942 denotes CD40
T1731 2057-2060 P05112 denotes IL4
T1732 2081-2085 P25942 denotes CD40
T1733 2173-2177 P25942 denotes CD40
T1734 2181-2186 P29965 denotes CD40L
T1735 2321-2325 P25942 denotes CD40
T1736 2336-2341 Q9Y4K3 denotes TRAF6
T1737 2550-2554 P03230 denotes LMP1
T1738 2566-2570 P25942 denotes CD40
T1739 2655-2659 P03230 denotes LMP1
T1740 2711-2716 Q9Y4K3 denotes TRAF6
T1741 2800-2804 P03230 denotes LMP1
T1742 2963-2967 P03230 denotes LMP1
T1743 3084-3088 P03230 denotes LMP1
T1744 3122-3126 P03230 denotes LMP1
T1745 3286-3290 P03230 denotes LMP1
T1746 3334-3338 P03230 denotes LMP1
T1747 3393-3396 P31751 denotes Akt
T1748 3393-3396 P31749 denotes Akt
T1749 3393-3396 Q9Y243 denotes Akt
T1750 3403-3406 Q15759 denotes p38
T1751 3403-3406 Q16539 denotes p38
T1752 3403-3406 P53778 denotes p38
T1753 3403-3406 O15264 denotes p38
T1754 3469-3473 Q04864 denotes cRel
T1755 3499-3503 P03230 denotes LMP1
T1756 3947-3951 P03230 denotes LMP1
T1757 4055-4058 P05112 denotes IL4
T1758 4078-4082 P03230 denotes LMP1
T1759 4141-4144 P05112 denotes IL4
T1760 4237-4242 P42226 denotes Stat6
T1761 4248-4251 P05112 denotes IL4
T1762 4328-4333 P40763 denotes Stat3
T1763 4358-4360 P06400 denotes Rb
T1764 4404-4407 Q9Y243 denotes Akt
T1765 4404-4407 P31749 denotes Akt
T1766 4404-4407 P31751 denotes Akt
T1767 4419-4424 P40763 denotes Stat3
T1768 4480-4484 P03230 denotes LMP1
T1769 4760-4764 P03230 denotes LMP1
T1770 4848-4851 Q9Y243 denotes Akt
T1771 4848-4851 P31751 denotes Akt
T1772 4848-4851 P31749 denotes Akt
T1773 4863-4868 P40763 denotes Stat3

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T608 904-929 Protein denotes Latent membrane protein 1
T609 931-935 Protein denotes LMP1
T610 1055-1064 Gene_expression denotes expressed
T611 1142-1146 Protein denotes LMP1
T612 1154-1158 Protein denotes CD40
T613 1179-1183 Protein denotes LMP1
T614 1188-1192 Protein denotes CD40
T615 1260-1264 Protein denotes CD40
T616 1265-1274 Binding denotes interacts
T617 1280-1291 Protein denotes CD40 ligand
T618 1292-1301 Gene_expression denotes expressed
T619 1372-1376 Protein denotes LMP1
T620 1451-1455 Protein denotes LMP1
T621 1460-1464 Protein denotes CD40
T622 1465-1473 Binding denotes interact
T623 1488-1509 Protein denotes tumor necrosis factor
T624 1577-1582 Protein denotes c-Jun
T625 1805-1809 Protein denotes LMP1
T626 1862-1865 Protein denotes Akt
T627 1917-1921 Protein denotes LMP1
T628 2023-2027 Protein denotes CD40
T629 2028-2036 Binding denotes ligation
T630 2057-2060 Protein denotes IL4
T631 2081-2085 Protein denotes CD40
T632 2159-2168 Negative_regulation denotes deficient
T633 2173-2177 Protein denotes CD40
T634 2181-2186 Protein denotes CD40L
T635 2298-2317 Entity denotes cytoplasmic regions
T636 2321-2325 Protein denotes CD40
T637 2331-2335 Binding denotes bind true true
T638 2336-2341 Protein denotes TRAF6 true true
T639 2346-2352 Protein denotes TRAFs2
T640 2353-2354 Protein denotes 3
T641 2355-2356 Protein denotes 5
T642 2550-2554 Protein denotes LMP1
T643 2566-2570 Protein denotes CD40
T644 2571-2580 Negative_regulation denotes deficient
T645 2655-2659 Protein denotes LMP1
T646 2660-2668 Binding denotes recruits
T647 2693-2700 Protein denotes TRAFs 1
T648 2701-2702 Protein denotes 2
T649 2703-2704 Protein denotes 3
T650 2705-2706 Protein denotes 5
T651 2711-2716 Protein denotes TRAF6
T652 2730-2761 Entity denotes C-terminal activation regions 1
T653 2766-2775 Entity denotes 2 domains
T654 2800-2804 Protein denotes LMP1
T655 2963-2967 Protein denotes LMP1
T656 2999-3008 Gene_expression denotes expressed
T657 3009-3026 Positive_regulation denotes under the control
T658 3084-3088 Protein denotes LMP1
T659 3114-3121 Gene_expression denotes express
T660 3122-3126 Protein denotes LMP1
T661 3286-3290 Protein denotes LMP1
T662 3334-3338 Protein denotes LMP1
T663 3383-3392 Positive_regulation denotes activated
T664 3393-3396 Protein denotes Akt
T665 3432-3442 Positive_regulation denotes activation
T666 3469-3473 Protein denotes cRel
T667 3499-3503 Protein denotes LMP1
T668 3947-3951 Protein denotes LMP1
T669 4026-4035 Positive_regulation denotes increased
T670 4055-4058 Protein denotes IL4
T671 4078-4082 Protein denotes LMP1
T672 4083-4091 Gene_expression denotes positive
T673 4141-4144 Protein denotes IL4
T674 4216-4223 Negative_regulation denotes absence
T675 4227-4236 Positive_regulation denotes activated
T676 4237-4242 Protein denotes Stat6
T677 4248-4251 Protein denotes IL4
T678 4314-4324 Positive_regulation denotes activation
T679 4328-4333 Protein denotes Stat3
T680 4358-4360 Protein denotes Rb
T681 4404-4407 Protein denotes Akt
T682 4419-4424 Protein denotes Stat3
T683 4480-4484 Protein denotes LMP1
T684 4760-4764 Protein denotes LMP1
T685 4848-4851 Protein denotes Akt
T686 4863-4868 Protein denotes Stat3
R425 T608 T610 themeOf Latent membrane protein 1,expressed
R426 T609 T608 equivalentTo LMP1,Latent membrane protein 1
R427 T615 T616 themeOf CD40,interacts
R428 T617 T616 themeOf CD40 ligand,interacts
R429 T617 T618 themeOf CD40 ligand,expressed
R430 T620 T622 themeOf LMP1,interact
R431 T621 T622 themeOf CD40,interact
R432 T623 T622 themeOf tumor necrosis factor,interact
R433 T628 T629 themeOf CD40,ligation
R434 T633 T632 themeOf CD40,deficient
R435 T634 T632 themeOf CD40L,deficient
R436 T635 T636 partOf cytoplasmic regions,CD40
R437 T638 T637 themeOf TRAF6,bind
R438 T639 T637 themeOf TRAFs2,bind
R439 T640 T637 themeOf 3,bind
R440 T641 T637 themeOf 5,bind
R441 T643 T644 themeOf CD40,deficient
R442 T645 T646 themeOf LMP1,recruits
R443 T647 T646 themeOf TRAFs 1,recruits
R444 T648 T646 themeOf 2,recruits
R445 T649 T646 themeOf 3,recruits
R446 T650 T646 themeOf 5,recruits
R447 T651 T646 themeOf TRAF6,recruits
R448 T652 T651 partOf C-terminal activation regions 1,TRAF6
R449 T652 T647 partOf C-terminal activation regions 1,TRAFs 1
R450 T652 T645 partOf C-terminal activation regions 1,LMP1
R451 T652 T646 themeOf C-terminal activation regions 1,recruits
R452 T653 T646 themeOf 2 domains,recruits
R453 T653 T645 partOf 2 domains,LMP1
R454 T655 T656 themeOf LMP1,expressed
R455 T656 T657 themeOf expressed,under the control
R456 T660 T659 themeOf LMP1,express
R457 T664 T663 themeOf Akt,activated
R458 T666 T665 themeOf cRel,activation
R459 T671 T672 themeOf LMP1,positive
R460 T675 T674 themeOf activated,absence
R461 T676 T675 themeOf Stat6,activated
R462 T679 T678 themeOf Stat3,activation