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2_test

Id Subject Object Predicate Lexical cue
17997602-3022942-98185704 2207-2208 3022942 denotes 3
17997602-8396685-98185705 2855-2856 8396685 denotes 4
17997602-16007144-98185705 2855-2856 16007144 denotes 4
17997602-7778675-98185705 2855-2856 7778675 denotes 4
17997602-3000618-98185705 2855-2856 3000618 denotes 4
17997602-2552313-98185705 2855-2856 2552313 denotes 4
17997602-12805559-98185706 2984-2985 12805559 denotes 9
17997602-8415670-98185706 2984-2985 8415670 denotes 9
17997602-7859281-98185706 2984-2985 7859281 denotes 9
17997602-8943365-98185707 3378-3380 8943365 denotes 12
17997602-9882303-98185707 3378-3380 9882303 denotes 12
17997602-14576817-98185707 3378-3380 14576817 denotes 12
17997602-9570524-98185707 3378-3380 9570524 denotes 12
17997602-9566902-98185707 3378-3380 9566902 denotes 12
17997602-10811897-98185708 3505-3507 10811897 denotes 17
17997602-15047827-98185709 3508-3510 15047827 denotes 18
17997602-16007144-98185710 3706-3707 16007144 denotes 5
17997602-12446712-98185711 3708-3710 12446712 denotes 19
17997602-7534202-98185712 3989-3991 7534202 denotes 20
17997602-7882172-98185713 3992-3994 7882172 denotes 21
17997602-11867568-98185714 4268-4270 11867568 denotes 22
17997602-10514374-98185715 4601-4603 10514374 denotes 23
17997602-9768760-98185716 4809-4811 9768760 denotes 24
17997602-15640350-98185716 4809-4811 15640350 denotes 24
17997602-9751773-98185716 4809-4811 9751773 denotes 24
17997602-9751773-98185717 5062-5064 9751773 denotes 26
17997602-16247482-98185718 5212-5214 16247482 denotes 27
17997602-7536467-98185719 5676-5678 7536467 denotes 28
17997602-1370214-98185720 5679-5681 1370214 denotes 29
17997602-10514374-98185721 7037-7039 10514374 denotes 23
17997602-9751773-98185722 7040-7042 9751773 denotes 26
17997602-3262873-98185723 10306-10308 3262873 denotes 30
17997602-9751773-98185724 11995-11997 9751773 denotes 26
17997602-16618600-98185725 12883-12885 16618600 denotes 31
17997602-1702555-98185726 13203-13205 1702555 denotes 32
17997602-12411306-98185727 21019-21021 12411306 denotes 33
17997602-11717333-98185728 21022-21024 11717333 denotes 34
17997602-8381152-98185729 21134-21136 8381152 denotes 35
17997602-11222718-98185729 21134-21136 11222718 denotes 35
17997602-10485371-98185729 21134-21136 10485371 denotes 35
17997602-8639912-98185729 21134-21136 8639912 denotes 35
17997602-16007144-98185730 24549-24550 16007144 denotes 5
17997602-15714459-98185731 24669-24671 15714459 denotes 39
17997602-15289331-98185732 24672-24674 15289331 denotes 40
17997602-15289331-98185733 25516-25518 15289331 denotes 40
17997602-15084260-98185734 26885-26887 15084260 denotes 41
17997602-15668399-98185735 26888-26890 15668399 denotes 42
17997602-10783894-98185736 27683-27685 10783894 denotes 43
17997602-11073996-98185737 27686-27688 11073996 denotes 44
17997602-8343202-98185738 27864-27866 8343202 denotes 45
17997602-15231645-98185739 29446-29448 15231645 denotes 46
17997602-10811897-98185740 31499-31501 10811897 denotes 17
17997602-15047827-98185741 31502-31504 15047827 denotes 18
17997602-12649187-98185742 32278-32280 12649187 denotes 47
17997602-12649187-98185743 32481-32483 12649187 denotes 47
17997602-9882303-98185744 33112-33114 9882303 denotes 13
17997602-10347160-98185745 33115-33117 10347160 denotes 48
17997602-9751773-98185746 34282-34284 9751773 denotes 26
17997602-7534202-98185747 35306-35308 7534202 denotes 20
17997602-10514374-98185748 35419-35421 10514374 denotes 23
17997602-15542676-98185749 35422-35424 15542676 denotes 49
17997602-9768760-98185750 35857-35859 9768760 denotes 24
17997602-14758357-98185751 35860-35862 14758357 denotes 50
17997602-15100272-98185752 35863-35865 15100272 denotes 51
17997602-15919890-98185753 35998-36000 15919890 denotes 52
17997602-16920914-98185754 36001-36003 16920914 denotes 53
17997602-10933592-98185755 36376-36378 10933592 denotes 54
17997602-7536467-98185756 36833-36835 7536467 denotes 28
17997602-1370214-98185757 36836-36838 1370214 denotes 29
17997602-3262873-98185758 37015-37017 3262873 denotes 30
17997602-15289331-98185759 37599-37601 15289331 denotes 40
17997602-9399941-98185760 37602-37604 9399941 denotes 55
17997602-10340377-98185760 37602-37604 10340377 denotes 55
17997602-10597317-98185760 37602-37604 10597317 denotes 55
17997602-14678988-98185760 37602-37604 14678988 denotes 55
17997602-7535370-98185761 38065-38067 7535370 denotes 59
17997602-8878429-98185762 38068-38070 8878429 denotes 60
17997602-8381152-98185763 38173-38175 8381152 denotes 35
17997602-11222718-98185763 38173-38175 11222718 denotes 35
17997602-10485371-98185763 38173-38175 10485371 denotes 35
17997602-8639912-98185763 38173-38175 8639912 denotes 35
17997602-8157362-98185764 38275-38277 8157362 denotes 61
17997602-11162833-98185765 38278-38280 11162833 denotes 62
17997602-14576817-98185766 38570-38572 14576817 denotes 14
17997602-14532284-98185767 38573-38575 14532284 denotes 63
17997602-14673102-98185767 38573-38575 14673102 denotes 63
17997602-12968033-98185767 38573-38575 12968033 denotes 63
17997602-11034392-98185768 38902-38904 11034392 denotes 66
17997602-9862367-98185768 38902-38904 9862367 denotes 66
17997602-9888854-98185768 38902-38904 9888854 denotes 66
17997602-16247482-98185769 39097-39099 16247482 denotes 27
17997602-11034392-98185770 39504-39506 11034392 denotes 66
17997602-15564458-98185771 39588-39590 15564458 denotes 69
17997602-15289331-98185772 39994-39996 15289331 denotes 40
17997602-15542676-98185773 40602-40604 15542676 denotes 49
17997602-16943287-98185774 40605-40607 16943287 denotes 70
17997602-11877469-98185775 40716-40718 11877469 denotes 71
17997602-10514374-98185776 40823-40825 10514374 denotes 23
17997602-15542676-98185777 40826-40828 15542676 denotes 49
17997602-9446632-98185778 41050-41052 9446632 denotes 72
17997602-9746758-98185779 41053-41055 9746758 denotes 73
17997602-16943287-98185780 41621-41623 16943287 denotes 70
17997602-9751773-98185781 42724-42726 9751773 denotes 26
17997602-9751773-98185782 42825-42827 9751773 denotes 26
17997602-8027546-98185783 48971-48973 8027546 denotes 74

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T73 0-3 NN denotes EBV
T74 4-10 JJ denotes Latent
T75 11-19 NN denotes Membrane
T76 20-27 NN denotes Protein
T77 28-29 CD denotes 1
T78 30-39 VB denotes Activates
T79 40-43 NNP denotes Akt
T80 43-44 -COMMA- denotes ,
T81 45-49 NN denotes NFκB
T82 49-50 -COMMA- denotes ,
T83 51-54 CC denotes and
T84 55-60 NN denotes Stat3
T85 61-63 IN denotes in
T86 64-65 NN denotes B
T87 66-70 NN denotes Cell
T88 71-80 NN denotes Lymphomas
T89 141-147 JJ denotes Latent
T90 148-156 NN denotes membrane
T91 157-164 NN denotes protein
T92 165-166 CD denotes 1
T93 167-168 -LRB- denotes (
T94 168-172 NN denotes LMP1
T95 172-173 -RRB- denotes )
T96 174-176 VB denotes is
T97 177-180 DT denotes the
T98 181-186 JJ denotes major
T99 187-198 NN denotes oncoprotein
T100 199-201 IN denotes of
T101 202-214 JJ denotes Epstein-Barr
T102 215-220 NN denotes virus
T103 221-222 -LRB- denotes (
T104 222-225 NN denotes EBV
T105 225-226 -RRB- denotes )
T106 228-230 IN denotes In
T107 231-241 JJ denotes transgenic
T108 242-246 NN denotes mice
T109 246-247 -COMMA- denotes ,
T110 248-252 NN denotes LMP1
T111 253-261 VB denotes promotes
T112 262-271 VB denotes increased
T113 272-280 NN denotes lymphoma
T114 281-292 NN denotes development
T115 293-295 IN denotes by
T116 296-298 CD denotes 12
T117 299-301 NN denotes mo
T118 302-304 IN denotes of
T119 305-308 NN denotes age
T120 310-314 DT denotes This
T121 315-320 NN denotes study
T122 321-328 VB denotes reveals
T123 329-333 IN denotes that
T124 334-342 NN denotes lymphoma
T125 343-351 VB denotes develops
T126 352-354 IN denotes in
T127 355-359 NN denotes B-1a
T128 360-371 NN denotes lymphocytes
T129 371-372 -COMMA- denotes ,
T130 373-374 DT denotes a
T131 375-385 NN denotes population
T132 386-390 WDT denotes that
T133 391-393 VB denotes is
T134 394-404 VB denotes associated
T135 405-409 IN denotes with
T136 410-424 NN denotes transformation
T137 425-427 IN denotes in
T138 428-433 JJ denotes older
T139 434-438 NN denotes mice
T140 440-443 DT denotes The
T141 444-452 NN denotes lymphoma
T142 453-458 NN denotes cells
T143 459-463 VB denotes have
T144 464-475 VB denotes deregulated
T145 476-480 NN denotes cell
T146 481-486 NN denotes cycle
T147 487-494 NN denotes markers
T148 494-495 -COMMA- denotes ,
T149 496-499 CC denotes and
T150 500-510 NN denotes inhibitors
T151 511-513 IN denotes of
T152 514-517 NN denotes Akt
T153 517-518 -COMMA- denotes ,
T154 519-523 NN denotes NFκB
T155 523-524 -COMMA- denotes ,
T156 525-528 CC denotes and
T157 529-534 NN denotes Stat3
T158 535-540 VB denotes block
T159 541-544 DT denotes the
T160 545-553 VB denotes enhanced
T161 554-563 NN denotes viability
T162 564-566 IN denotes of
T163 567-571 NN denotes LMP1
T164 572-582 JJ denotes transgenic
T165 583-594 NN denotes lymphocytes
T166 595-598 CC denotes and
T167 599-607 NN denotes lymphoma
T168 608-613 NN denotes cells
T169 614-616 FW denotes in
T170 617-622 FW denotes vitro
T171 624-632 NN denotes Lymphoma
T172 633-638 NN denotes cells
T173 639-642 VB denotes are
T174 643-654 JJ denotes independent
T175 655-657 IN denotes of
T176 658-667 NN denotes IL4/Stat6
T177 668-677 NN denotes signaling
T178 678-681 IN denotes for
T179 682-690 NN denotes survival
T180 691-694 CC denotes and
T181 695-708 NN denotes proliferation
T182 708-709 -COMMA- denotes ,
T183 710-713 CC denotes but
T184 714-718 VB denotes have
T185 719-733 RB denotes constitutively
T186 734-743 VB denotes activated
T187 744-749 NN denotes Stat3
T188 750-759 NN denotes signaling
T189 761-766 DT denotes These
T190 767-771 JJ denotes same
T191 772-779 NN denotes targets
T192 780-783 VB denotes are
T193 784-788 RB denotes also
T194 789-800 VB denotes deregulated
T195 801-803 IN denotes in
T196 804-813 JJ denotes wild-type
T197 814-818 NN denotes B-1a
T198 819-828 NN denotes lymphomas
T199 829-833 WDT denotes that
T200 834-839 VB denotes arise
T201 840-853 RB denotes spontaneously
T202 854-861 IN denotes through
T203 862-865 NN denotes age
T204 866-880 NN denotes predisposition
T205 882-887 DT denotes These
T206 888-895 NN denotes results
T207 896-903 VB denotes suggest
T208 904-908 IN denotes that
T209 909-912 NN denotes Akt
T210 912-913 -COMMA- denotes ,
T211 914-918 NN denotes NFκB
T212 918-919 -COMMA- denotes ,
T213 920-923 CC denotes and
T214 924-929 NN denotes Stat3
T215 930-938 NN denotes pathways
T216 939-942 MD denotes may
T217 943-948 VB denotes serve
T218 949-951 IN denotes as
T219 952-961 JJ denotes effective
T220 962-969 NN denotes targets
T221 970-972 IN denotes in
T222 973-976 DT denotes the
T223 977-986 NN denotes treatment
T224 987-989 IN denotes of
T225 990-1004 JJ denotes EBV-associated
T226 1005-1006 NN denotes B
T227 1007-1011 NN denotes cell
T228 1012-1021 NN denotes lymphomas
T880 1750-1762 JJ denotes Epstein-Barr
T881 1763-1768 NN denotes virus
T882 1769-1770 -LRB- denotes (
T883 1770-1773 NN denotes EBV
T884 1773-1774 -RRB- denotes )
T885 1775-1777 VB denotes is
T886 1778-1779 DT denotes a
T887 1780-1790 JJ denotes ubiquitous
T888 1791-1804 NN denotes γ-herpesvirus
T889 1805-1809 WDT denotes that
T890 1810-1817 VB denotes infects
T891 1818-1824 NN denotes humans
T892 1825-1838 RB denotes predominantly
T893 1839-1841 IN denotes at
T894 1842-1844 DT denotes an
T895 1845-1850 JJ denotes early
T896 1851-1854 NN denotes age
T897 1855-1859 IN denotes with
T898 1860-1867 JJ denotes greater
T899 1868-1872 IN denotes than
T900 1873-1875 CD denotes 90
T901 1875-1876 NN denotes %
T902 1877-1879 IN denotes of
T903 1880-1883 DT denotes the
T904 1884-1889 JJ denotes adult
T905 1890-1900 NN denotes population
T906 1901-1909 VB denotes infected
T907 1910-1914 IN denotes with
T908 1915-1918 NN denotes EBV
T909 1919-1920 -LRB- denotes [
T910 1920-1921 CD denotes 1
T911 1921-1922 -RRB- denotes ]
T912 1924-1927 NN denotes EBV
T913 1928-1930 VB denotes is
T914 1931-1937 VB denotes linked
T915 1938-1940 TO denotes to
T916 1941-1944 DT denotes the
T917 1945-1956 NN denotes development
T918 1957-1959 IN denotes of
T919 1960-1964 CC denotes both
T920 1965-1966 NN denotes B
T921 1967-1977 NN denotes lymphocyte
T922 1978-1981 CC denotes and
T923 1982-1992 JJ denotes epithelial
T924 1993-1997 NN denotes cell
T925 1998-2010 NN denotes malignancies
T926 2010-2011 -COMMA- denotes ,
T927 2012-2021 VB denotes including
T928 2022-2029 NN denotes Burkitt
T929 2030-2038 NN denotes lymphoma
T930 2038-2039 -COMMA- denotes ,
T931 2040-2047 NN denotes Hodgkin
T932 2048-2055 NN denotes disease
T933 2056-2057 -LRB- denotes (
T934 2057-2059 NN denotes HD
T935 2059-2060 -RRB- denotes )
T936 2060-2061 -COMMA- denotes ,
T937 2062-2065 CC denotes and
T938 2066-2080 JJ denotes nasopharyngeal
T939 2081-2090 NN denotes carcinoma
T940 2091-2092 -LRB- denotes (
T941 2092-2095 NN denotes NPC
T942 2095-2096 -RRB- denotes )
T943 2096-2097 -COMMA- denotes ,
T944 2098-2101 CC denotes and
T945 2102-2109 NN denotes cancers
T946 2110-2116 VB denotes linked
T947 2117-2119 TO denotes to
T948 2120-2137 NN denotes immunosuppression
T949 2137-2138 -COMMA- denotes ,
T950 2139-2148 VB denotes including
T951 2149-2164 JJ denotes post-transplant
T952 2165-2173 NN denotes lymphoma
T953 2174-2177 CC denotes and
T954 2178-2193 JJ denotes AIDS-associated
T955 2194-2203 NN denotes lymphomas
T956 2204-2205 -LRB- denotes [
T957 2205-2208 CD denotes 2,3
T958 2208-2209 -RRB- denotes ]
T959 2211-2213 FW denotes In
T960 2214-2219 FW denotes vitro
T961 2220-2229 NN denotes infection
T962 2230-2232 IN denotes of
T963 2233-2234 NN denotes B
T964 2235-2246 NN denotes lymphocytes
T965 2247-2251 IN denotes with
T966 2252-2255 NN denotes EBV
T967 2256-2263 VB denotes induces
T968 2264-2273 JJ denotes permanent
T969 2274-2280 NN denotes growth
T970 2281-2295 NN denotes transformation
T971 2295-2296 -COMMA- denotes ,
T972 2297-2300 CC denotes and
T973 2301-2305 DT denotes this
T974 2306-2313 NN denotes ability
T975 2314-2316 TO denotes to
T976 2317-2323 VB denotes affect
T977 2324-2328 NN denotes cell
T978 2329-2335 NN denotes growth
T979 2336-2346 NN denotes regulation
T980 2347-2353 RB denotes likely
T981 2354-2365 VB denotes contributes
T982 2366-2368 TO denotes to
T983 2369-2372 DT denotes the
T984 2373-2384 NN denotes development
T985 2385-2387 IN denotes of
T986 2388-2394 NN denotes cancer
T987 2396-2400 JJ denotes Many
T988 2401-2403 IN denotes of
T989 2404-2407 DT denotes the
T990 2408-2413 JJ denotes viral
T991 2414-2422 NN denotes proteins
T992 2423-2432 VB denotes expressed
T993 2433-2435 IN denotes in
T994 2436-2447 VB denotes transformed
T995 2448-2453 NN denotes cells
T996 2453-2454 -COMMA- denotes ,
T997 2455-2464 VB denotes including
T998 2465-2468 DT denotes the
T999 2469-2472 NN denotes EBV
T1000 2473-2480 JJ denotes nuclear
T1001 2481-2489 NN denotes antigens
T1002 2490-2493 CC denotes and
T1003 2494-2500 JJ denotes latent
T1004 2501-2509 NN denotes membrane
T1005 2510-2518 NN denotes proteins
T1006 2518-2519 -COMMA- denotes ,
T1007 2520-2524 VB denotes have
T1008 2525-2533 JJ denotes profound
T1009 2534-2541 NN denotes effects
T1010 2542-2544 IN denotes on
T1011 2545-2549 NN denotes cell
T1012 2550-2556 NN denotes growth
T1013 2557-2567 NN denotes regulation
T1014 2568-2571 CC denotes and
T1015 2572-2575 VB denotes are
T1016 2576-2584 VB denotes required
T1017 2585-2588 IN denotes for
T1018 2589-2592 NN denotes EBV
T1019 2593-2599 JJ denotes latent
T1020 2600-2609 NN denotes infection
T1021 2610-2613 CC denotes and
T1022 2614-2615 NN denotes B
T1023 2616-2620 NN denotes cell
T1024 2621-2635 NN denotes transformation
T1025 2636-2637 -LRB- denotes [
T1026 2637-2638 CD denotes 1
T1027 2638-2639 -RRB- denotes ]
T1028 2641-2647 JJ denotes Latent
T1029 2648-2656 NN denotes membrane
T1030 2657-2664 NN denotes protein
T1031 2665-2666 CD denotes 1
T1032 2667-2668 -LRB- denotes (
T1033 2668-2672 NN denotes LMP1
T1034 2672-2673 -RRB- denotes )
T1035 2674-2676 VB denotes is
T1036 2677-2687 VB denotes considered
T1037 2688-2691 DT denotes the
T1038 2692-2697 JJ denotes major
T1039 2698-2709 NN denotes oncoprotein
T1040 2710-2712 IN denotes of
T1041 2713-2716 NN denotes EBV
T1042 2716-2717 -COMMA- denotes ,
T1043 2718-2720 IN denotes as
T1044 2721-2723 PRP denotes it
T1045 2724-2734 VB denotes transforms
T1046 2735-2741 JJ denotes rodent
T1047 2742-2753 NN denotes fibroblasts
T1048 2754-2756 TO denotes to
T1049 2757-2771 NN denotes tumorigenicity
T1050 2772-2774 IN denotes in
T1051 2775-2779 JJ denotes nude
T1052 2780-2784 NN denotes mice
T1053 2785-2788 CC denotes and
T1054 2789-2791 VB denotes is
T1055 2792-2801 VB denotes expressed
T1056 2802-2804 IN denotes in
T1057 2805-2807 NN denotes HD
T1058 2807-2808 -COMMA- denotes ,
T1059 2809-2812 NN denotes NPC
T1060 2812-2813 -COMMA- denotes ,
T1061 2814-2817 CC denotes and
T1062 2818-2846 JJ denotes immunosuppression-associated
T1063 2847-2853 NN denotes tumors
T1064 2854-2855 -LRB- denotes [
T1065 2855-2858 CD denotes 4–8
T1066 2858-2859 -RRB- denotes ]
T1067 2861-2863 IN denotes In
T1068 2864-2865 NN denotes B
T1069 2866-2877 NN denotes lymphocytes
T1070 2877-2878 -COMMA- denotes ,
T1071 2879-2883 NN denotes LMP1
T1072 2884-2890 VB denotes mimics
T1073 2891-2895 NN denotes CD40
T1074 2896-2905 NN denotes signaling
T1075 2905-2906 -COMMA- denotes ,
T1076 2907-2910 CC denotes and
T1077 2911-2915 CC denotes both
T1078 2916-2920 NN denotes LMP1
T1079 2921-2924 CC denotes and
T1080 2925-2929 NN denotes CD40
T1081 2930-2933 VB denotes are
T1082 2934-2943 JJ denotes essential
T1083 2944-2947 IN denotes for
T1084 2948-2960 JJ denotes EBV-mediated
T1085 2961-2962 NN denotes B
T1086 2963-2967 NN denotes cell
T1087 2968-2982 NN denotes transformation
T1088 2983-2984 -LRB- denotes [
T1089 2984-2988 CD denotes 9–11
T1090 2988-2989 -RRB- denotes ]
T1091 2991-2996 IN denotes While
T1092 2997-3001 NN denotes CD40
T1093 3002-3011 VB denotes interacts
T1094 3012-3016 IN denotes with
T1095 3017-3021 NN denotes CD40
T1096 3022-3028 NN denotes ligand
T1097 3029-3038 VB denotes expressed
T1098 3039-3041 IN denotes on
T1099 3042-3051 VB denotes activated
T1100 3052-3053 NN denotes T
T1101 3054-3059 NN denotes cells
T1102 3060-3062 TO denotes to
T1103 3063-3069 VB denotes induce
T1104 3070-3071 NN denotes B
T1105 3072-3076 NN denotes cell
T1106 3077-3087 NN denotes activation
T1107 3088-3091 CC denotes and
T1108 3092-3107 NN denotes differentiation
T1109 3107-3108 -COMMA- denotes ,
T1110 3109-3113 NN denotes LMP1
T1111 3114-3118 VB denotes acts
T1112 3119-3121 IN denotes as
T1113 3122-3123 DT denotes a
T1114 3124-3136 JJ denotes constitutive
T1115 3137-3143 NN denotes signal
T1116 3144-3151 IN denotes through
T1117 3152-3170 JJ denotes ligand-independent
T1118 3171-3186 NN denotes oligomerization
T1119 3188-3192 NN denotes LMP1
T1120 3193-3196 CC denotes and
T1121 3197-3201 NN denotes CD40
T1122 3202-3210 VB denotes interact
T1123 3211-3215 IN denotes with
T1124 3216-3219 DT denotes the
T1125 3220-3224 JJ denotes same
T1126 3225-3230 NN denotes tumor
T1127 3231-3239 NN denotes necrosis
T1128 3240-3246 NN denotes factor
T1129 3247-3266 VB denotes receptor–associated
T1130 3267-3274 NN denotes factors
T1131 3275-3276 -LRB- denotes (
T1132 3276-3281 NN denotes TRAFs
T1133 3281-3282 -RRB- denotes )
T1134 3283-3290 VB denotes leading
T1135 3291-3293 TO denotes to
T1136 3294-3304 NN denotes activation
T1137 3305-3307 IN denotes of
T1138 3308-3312 NN denotes NFκB
T1139 3312-3313 -COMMA- denotes ,
T1140 3314-3319 NN denotes c-Jun
T1141 3320-3321 NN denotes N
T1142 3322-3330 JJ denotes terminal
T1143 3331-3337 NN denotes kinase
T1144 3338-3339 -LRB- denotes (
T1145 3339-3342 NN denotes JNK
T1146 3342-3343 -RRB- denotes )
T1147 3343-3344 -COMMA- denotes ,
T1148 3345-3348 CC denotes and
T1149 3349-3352 NN denotes p38
T1150 3353-3357 NN denotes MAPK
T1151 3358-3367 NN denotes signaling
T1152 3368-3376 NN denotes pathways
T1153 3377-3378 -LRB- denotes [
T1154 3378-3383 CD denotes 12–16
T1155 3383-3384 -RRB- denotes ]
T1156 3386-3396 NN denotes Activation
T1157 3397-3399 IN denotes of
T1158 3400-3404 NN denotes NFκB
T1159 3405-3407 VB denotes is
T1160 3408-3416 VB denotes required
T1161 3417-3420 IN denotes for
T1162 3421-3432 JJ denotes EBV-induced
T1163 3433-3434 NN denotes B
T1164 3435-3439 NN denotes cell
T1165 3440-3454 NN denotes transformation
T1166 3455-3458 CC denotes and
T1167 3459-3462 PRP-DOLLAR- denotes its
T1168 3463-3473 NN denotes inhibition
T1169 3474-3481 RB denotes rapidly
T1170 3482-3489 VB denotes results
T1171 3490-3492 IN denotes in
T1172 3493-3497 NN denotes cell
T1173 3498-3503 NN denotes death
T1174 3504-3505 -LRB- denotes [
T1175 3505-3510 CD denotes 17,18
T1176 3510-3511 -RRB- denotes ]
T1177 3513-3519 JJ denotes Recent
T1178 3520-3527 NN denotes studies
T1179 3528-3536 VB denotes indicate
T1180 3537-3541 IN denotes that
T1181 3542-3546 NN denotes LMP1
T1182 3547-3551 RB denotes also
T1183 3552-3561 VB denotes activates
T1184 3562-3582 NN denotes phosphatidylinositol
T1185 3583-3584 CD denotes 3
T1186 3585-3591 NN denotes kinase
T1187 3592-3593 -LRB- denotes (
T1188 3593-3597 NN denotes PI3K
T1189 3597-3598 -RRB- denotes )
T1190 3598-3602 NN denotes /Akt
T1191 3603-3612 NN denotes signaling
T1192 3613-3616 CC denotes and
T1193 3617-3621 IN denotes that
T1194 3622-3626 DT denotes this
T1195 3627-3637 NN denotes activation
T1196 3638-3640 VB denotes is
T1197 3641-3649 VB denotes required
T1198 3650-3653 IN denotes for
T1199 3654-3667 JJ denotes LMP1-mediated
T1200 3668-3682 NN denotes transformation
T1201 3683-3685 IN denotes of
T1202 3686-3692 JJ denotes rodent
T1203 3693-3704 NN denotes fibroblasts
T1204 3705-3706 -LRB- denotes [
T1205 3706-3710 CD denotes 5,19
T1206 3710-3711 -RRB- denotes ]
T1207 3713-3715 FW denotes In
T1208 3716-3721 FW denotes vitro
T1209 3721-3722 -COMMA- denotes ,
T1210 3723-3730 JJ denotes primary
T1211 3731-3732 NN denotes B
T1212 3733-3738 NN denotes cells
T1213 3739-3742 MD denotes can
T1214 3743-3745 VB denotes be
T1215 3746-3756 VB denotes maintained
T1216 3757-3759 IN denotes by
T1217 3760-3764 NN denotes CD40
T1218 3765-3773 NN denotes ligation
T1219 3774-3776 IN denotes in
T1220 3777-3788 NN denotes combination
T1221 3789-3793 IN denotes with
T1222 3794-3797 NN denotes IL4
T1223 3798-3807 NN denotes treatment
T1224 3809-3811 FW denotes In
T1225 3812-3816 FW denotes vivo
T1226 3816-3817 -COMMA- denotes ,
T1227 3818-3822 NN denotes CD40
T1228 3823-3832 NN denotes signaling
T1229 3833-3835 VB denotes is
T1230 3836-3845 JJ denotes necessary
T1231 3846-3849 IN denotes for
T1232 3850-3858 JJ denotes germinal
T1233 3859-3865 NN denotes center
T1234 3866-3867 -LRB- denotes (
T1235 3867-3869 NN denotes GC
T1236 3869-3870 -RRB- denotes )
T1237 3871-3880 NN denotes formation
T1238 3881-3885 JJ denotes such
T1239 3886-3890 IN denotes that
T1240 3891-3895 NN denotes mice
T1241 3896-3905 JJ denotes deficient
T1242 3906-3909 IN denotes for
T1243 3910-3914 NN denotes CD40
T1244 3915-3917 CC denotes or
T1245 3918-3923 NN denotes CD40L
T1246 3924-3927 VB denotes are
T1247 3928-3934 JJ denotes unable
T1248 3935-3937 TO denotes to
T1249 3938-3942 VB denotes form
T1250 3943-3946 NN denotes GCs
T1251 3947-3949 IN denotes in
T1252 3950-3958 NN denotes response
T1253 3959-3961 TO denotes to
T1254 3962-3963 NN denotes T
T1255 3964-3978 JJ denotes cell–dependent
T1256 3979-3987 NN denotes antigens
T1257 3988-3989 -LRB- denotes [
T1258 3989-3994 CD denotes 20,21
T1259 3994-3995 -RRB- denotes ]
T1260 3997-4001 CC denotes Both
T1261 4002-4005 DT denotes the
T1262 4006-4014 NN denotes membrane
T1263 4015-4023 JJ denotes proximal
T1264 4024-4027 CC denotes and
T1265 4028-4034 JJ denotes distal
T1266 4035-4046 JJ denotes cytoplasmic
T1267 4047-4054 NN denotes regions
T1268 4055-4057 IN denotes of
T1269 4058-4062 NN denotes CD40
T1270 4063-4067 WDT denotes that
T1271 4068-4072 VB denotes bind
T1272 4073-4078 NN denotes TRAF6
T1273 4079-4082 CC denotes and
T1274 4083-4093 NN denotes TRAFs2/3/5
T1275 4093-4094 -COMMA- denotes ,
T1276 4095-4107 RB denotes respectively
T1277 4107-4108 -COMMA- denotes ,
T1278 4109-4112 VB denotes are
T1279 4113-4122 JJ denotes necessary
T1280 4123-4126 IN denotes for
T1281 4127-4129 NN denotes GC
T1282 4130-4139 NN denotes formation
T1283 4139-4140 -COMMA- denotes ,
T1284 4141-4144 CC denotes but
T1285 4145-4151 CC denotes either
T1286 4152-4158 NN denotes region
T1287 4159-4161 VB denotes is
T1288 4162-4172 JJ denotes sufficient
T1289 4173-4175 TO denotes to
T1290 4176-4182 VB denotes induce
T1291 4183-4198 JJ denotes extrafollicular
T1292 4199-4200 NN denotes B
T1293 4201-4205 NN denotes cell
T1294 4206-4221 NN denotes differentiation
T1295 4222-4225 CC denotes and
T1296 4226-4233 VB denotes restore
T1297 4234-4237 JJ denotes low
T1298 4238-4246 NN denotes affinity
T1299 4247-4255 NN denotes antibody
T1300 4256-4266 NN denotes production
T1301 4267-4268 -LRB- denotes [
T1302 4268-4270 CD denotes 22
T1303 4270-4271 -RRB- denotes ]
T1304 4273-4285 RB denotes Functionally
T1305 4285-4286 -COMMA- denotes ,
T1306 4287-4291 NN denotes LMP1
T1307 4292-4295 MD denotes can
T1308 4296-4302 VB denotes rescue
T1309 4303-4317 JJ denotes CD40-deficient
T1310 4318-4322 NN denotes mice
T1311 4323-4326 CC denotes and
T1312 4327-4334 VB denotes restore
T1313 4335-4349 NN denotes immunoglobulin
T1314 4350-4351 -LRB- denotes (
T1315 4351-4353 NN denotes Ig
T1316 4353-4354 -RRB- denotes )
T1317 4355-4360 NN denotes class
T1318 4361-4370 NN denotes switching
T1319 4370-4371 -COMMA- denotes ,
T1320 4372-4376 RB denotes most
T1321 4377-4383 RB denotes likely
T1322 4384-4391 IN denotes because
T1323 4392-4396 NN denotes LMP1
T1324 4397-4405 VB denotes recruits
T1325 4406-4413 JJ denotes similar
T1326 4414-4418 NN denotes TRAF
T1327 4419-4428 NN denotes molecules
T1328 4428-4429 -COMMA- denotes ,
T1329 4430-4435 NN denotes TRAFs
T1330 4436-4443 CD denotes 1/2/3/5
T1331 4444-4447 CC denotes and
T1332 4448-4453 NN denotes TRAF6
T1333 4453-4454 -COMMA- denotes ,
T1334 4455-4462 IN denotes through
T1335 4463-4466 DT denotes the
T1336 4467-4477 JJ denotes C-terminal
T1337 4478-4488 NN denotes activation
T1338 4489-4496 NN denotes regions
T1339 4497-4498 CD denotes 1
T1340 4499-4502 CC denotes and
T1341 4503-4504 CD denotes 2
T1342 4505-4512 NN denotes domains
T1343 4512-4513 -COMMA- denotes ,
T1344 4514-4526 RB denotes respectively
T1345 4528-4535 RB denotes However
T1346 4535-4536 -COMMA- denotes ,
T1347 4537-4541 NN denotes LMP1
T1348 4542-4544 VB denotes is
T1349 4545-4551 JJ denotes unable
T1350 4552-4554 TO denotes to
T1351 4555-4562 VB denotes restore
T1352 4563-4571 NN denotes affinity
T1353 4572-4582 NN denotes maturation
T1354 4583-4586 CC denotes and
T1355 4587-4589 NN denotes GC
T1356 4590-4599 NN denotes formation
T1357 4600-4601 -LRB- denotes [
T1358 4601-4603 CD denotes 23
T1359 4603-4604 -RRB- denotes ]
T1360 4606-4613 JJ denotes Several
T1361 4614-4617 NN denotes EBV
T1362 4618-4630 VB denotes transforming
T1363 4631-4639 NN denotes proteins
T1364 4640-4644 VB denotes have
T1365 4645-4649 VB denotes been
T1366 4650-4657 VB denotes studied
T1367 4658-4660 IN denotes in
T1368 4661-4671 JJ denotes transgenic
T1369 4672-4677 NN denotes mouse
T1370 4678-4684 NN denotes models
T1371 4684-4685 -COMMA- denotes ,
T1372 4686-4693 RB denotes however
T1373 4693-4694 -COMMA- denotes ,
T1374 4695-4699 RB denotes only
T1375 4700-4704 NN denotes LMP1
T1376 4705-4712 VB denotes induces
T1377 4713-4718 NN denotes tumor
T1378 4719-4730 NN denotes development
T1379 4731-4735 WRB denotes when
T1380 4736-4745 VB denotes expressed
T1381 4746-4751 IN denotes under
T1382 4752-4755 DT denotes the
T1383 4756-4763 NN denotes control
T1384 4764-4766 IN denotes of
T1385 4767-4770 DT denotes the
T1386 4771-4773 NN denotes Ig
T1387 4774-4779 JJ denotes heavy
T1388 4780-4785 NN denotes chain
T1389 4786-4794 NN denotes promoter
T1390 4795-4798 CC denotes and
T1391 4799-4807 NN denotes enhancer
T1392 4808-4809 -LRB- denotes [
T1393 4809-4814 CD denotes 24–26
T1394 4814-4815 -RRB- denotes ]
T1395 4817-4820 DT denotes The
T1396 4821-4825 NN denotes LMP1
T1397 4826-4836 JJ denotes transgenic
T1398 4837-4841 NN denotes mice
T1399 4842-4843 -LRB- denotes (
T1400 4843-4849 NN denotes IgLMP1
T1401 4849-4850 -RRB- denotes )
T1402 4851-4858 VB denotes express
T1403 4859-4863 NN denotes LMP1
T1404 4864-4866 IN denotes in
T1405 4867-4868 NN denotes B
T1406 4869-4880 NN denotes lymphocytes
T1407 4880-4881 -COMMA- denotes ,
T1408 4882-4885 CC denotes and
T1409 4886-4888 IN denotes in
T1410 4889-4893 NN denotes mice
T1411 4894-4899 JJ denotes older
T1412 4900-4904 IN denotes than
T1413 4905-4907 CD denotes 12
T1414 4908-4910 NN denotes mo
T1415 4910-4911 -COMMA- denotes ,
T1416 4912-4920 NN denotes lymphoma
T1417 4921-4929 VB denotes develops
T1418 4930-4934 IN denotes with
T1419 4935-4944 VB denotes increased
T1420 4945-4954 NN denotes incidence
T1421 4955-4956 -LRB- denotes (
T1422 4956-4958 CD denotes 40
T1423 4958-4959 NN denotes %
T1424 4959-4962 CD denotes –50
T1425 4962-4963 NN denotes %
T1426 4963-4964 -RRB- denotes )
T1427 4965-4973 VB denotes compared
T1428 4974-4976 TO denotes to
T1429 4977-4986 JJ denotes wild-type
T1430 4987-4994 NN denotes control
T1431 4995-4999 NN denotes mice
T1432 5000-5001 -LRB- denotes (
T1433 5001-5003 CD denotes 11
T1434 5003-5004 NN denotes %
T1435 5004-5005 -RRB- denotes )
T1436 5005-5006 -COMMA- denotes ,
T1437 5007-5017 VB denotes suggesting
T1438 5018-5022 IN denotes that
T1439 5023-5027 NN denotes LMP1
T1440 5028-5039 VB denotes contributes
T1441 5040-5042 TO denotes to
T1442 5043-5048 NN denotes tumor
T1443 5049-5060 NN denotes development
T1444 5061-5062 -LRB- denotes [
T1445 5062-5064 CD denotes 26
T1446 5064-5065 -RRB- denotes ]
T1447 5067-5070 DT denotes The
T1448 5071-5075 NN denotes LMP1
T1449 5076-5085 NN denotes lymphomas
T1450 5086-5090 VB denotes have
T1451 5091-5101 VB denotes rearranged
T1452 5102-5104 NN denotes Ig
T1453 5105-5110 NN denotes genes
T1454 5111-5114 CC denotes and
T1455 5115-5119 VB denotes have
T1456 5120-5129 VB denotes activated
T1457 5130-5133 NN denotes Akt
T1458 5133-5134 -COMMA- denotes ,
T1459 5135-5138 NN denotes JNK
T1460 5138-5139 -COMMA- denotes ,
T1461 5140-5143 NN denotes p38
T1462 5143-5144 -COMMA- denotes ,
T1463 5145-5148 CC denotes and
T1464 5149-5153 NN denotes NFκB
T1465 5153-5154 -COMMA- denotes ,
T1466 5155-5159 IN denotes with
T1467 5160-5168 JJ denotes specific
T1468 5169-5179 NN denotes activation
T1469 5180-5182 IN denotes of
T1470 5183-5186 DT denotes the
T1471 5187-5191 NN denotes NFκB
T1472 5192-5198 NN denotes family
T1473 5199-5205 NN denotes member
T1474 5206-5210 NN denotes cRel
T1475 5211-5212 -LRB- denotes [
T1476 5212-5214 CD denotes 27
T1477 5214-5215 -RRB- denotes ]
T1478 5217-5219 IN denotes In
T1479 5220-5224 DT denotes this
T1480 5225-5230 NN denotes study
T1481 5230-5231 -COMMA- denotes ,
T1482 5232-5235 DT denotes the
T1483 5236-5240 NN denotes LMP1
T1484 5241-5251 JJ denotes transgenic
T1485 5252-5263 NN denotes lymphocytes
T1486 5264-5267 CC denotes and
T1487 5268-5277 NN denotes lymphomas
T1488 5278-5282 VB denotes were
T1489 5283-5290 RB denotes further
T1490 5291-5304 VB denotes characterized
T1491 5305-5308 CC denotes and
T1492 5309-5314 PRP-DOLLAR- denotes their
T1493 5315-5321 NN denotes growth
T1494 5322-5332 NN denotes properties
T1495 5333-5335 FW denotes in
T1496 5336-5341 FW denotes vitro
T1497 5342-5346 VB denotes were
T1498 5347-5357 VB denotes determined
T1499 5359-5361 TO denotes To
T1500 5362-5368 VB denotes obtain
T1501 5369-5373 JJ denotes pure
T1502 5374-5385 NN denotes populations
T1503 5386-5388 IN denotes of
T1504 5389-5398 JJ denotes malignant
T1505 5399-5410 NN denotes lymphocytes
T1506 5411-5414 CC denotes and
T1507 5415-5417 TO denotes to
T1508 5418-5424 VB denotes enable
T1509 5425-5429 RB denotes more
T1510 5430-5438 JJ denotes detailed
T1511 5439-5450 JJ denotes biochemical
T1512 5451-5459 NN denotes analyses
T1513 5459-5460 -COMMA- denotes ,
T1514 5461-5469 NN denotes examples
T1515 5470-5472 IN denotes of
T1516 5473-5480 JJ denotes primary
T1517 5481-5490 NN denotes lymphomas
T1518 5491-5495 VB denotes were
T1519 5496-5506 VB denotes inoculated
T1520 5507-5510 CC denotes and
T1521 5511-5519 VB denotes passaged
T1522 5520-5522 IN denotes in
T1523 5523-5527 NN denotes SCID
T1524 5528-5532 NN denotes mice
T1525 5534-5547 RB denotes Interestingly
T1526 5547-5548 -COMMA- denotes ,
T1527 5549-5557 NN denotes lymphoma
T1528 5558-5569 NN denotes development
T1529 5570-5573 VB denotes was
T1530 5574-5584 JJ denotes restricted
T1531 5585-5587 TO denotes to
T1532 5588-5592 NN denotes B-1a
T1533 5593-5604 NN denotes lymphocytes
T1534 5604-5605 -COMMA- denotes ,
T1535 5606-5607 DT denotes a
T1536 5608-5625 JJ denotes self-replenishing
T1537 5626-5636 NN denotes population
T1538 5637-5639 IN denotes of
T1539 5640-5645 NN denotes cells
T1540 5646-5650 WDT denotes that
T1541 5651-5654 VB denotes are
T1542 5655-5660 JJ denotes prone
T1543 5661-5663 TO denotes to
T1544 5664-5674 NN denotes malignancy
T1545 5675-5676 -LRB- denotes [
T1546 5676-5681 CD denotes 28,29
T1547 5681-5682 -RRB- denotes ]
T1548 5684-5688 NN denotes LMP1
T1549 5689-5699 JJ denotes transgenic
T1550 5700-5711 NN denotes lymphocytes
T1551 5712-5715 VB denotes had
T1552 5716-5725 VB denotes increased
T1553 5726-5735 NN denotes viability
T1554 5736-5738 FW denotes in
T1555 5739-5744 FW denotes vitro
T1556 5745-5748 CC denotes and
T1557 5749-5758 NN denotes viability
T1558 5759-5762 VB denotes was
T1559 5763-5772 VB denotes increased
T1560 5773-5775 IN denotes by
T1561 5776-5779 DT denotes the
T1562 5780-5788 NN denotes addition
T1563 5789-5791 IN denotes of
T1564 5792-5795 NN denotes IL4
T1565 5797-5799 IN denotes In
T1566 5800-5808 NN denotes contrast
T1567 5808-5809 -COMMA- denotes ,
T1568 5810-5814 CC denotes both
T1569 5815-5828 JJ denotes LMP1-positive
T1570 5829-5832 CC denotes and
T1571 5833-5842 JJ denotes -negative
T1572 5843-5851 NN denotes lymphoma
T1573 5852-5857 NN denotes cells
T1574 5858-5862 VB denotes were
T1575 5863-5874 JJ denotes independent
T1576 5875-5877 IN denotes of
T1577 5878-5881 NN denotes IL4
T1578 5882-5896 NN denotes co-stimulation
T1579 5897-5900 IN denotes for
T1580 5901-5909 NN denotes survival
T1581 5910-5913 CC denotes and
T1582 5914-5927 NN denotes proliferation
T1583 5928-5930 FW denotes in
T1584 5931-5936 FW denotes vitro
T1585 5937-5941 IN denotes with
T1586 5942-5943 DT denotes a
T1587 5944-5952 JJ denotes complete
T1588 5953-5960 NN denotes absence
T1589 5961-5963 IN denotes of
T1590 5964-5973 VB denotes activated
T1591 5974-5979 NN denotes Stat6
T1592 5979-5980 -COMMA- denotes ,
T1593 5981-5984 DT denotes the
T1594 5985-5988 NN denotes IL4
T1595 5989-5995 NN denotes target
T1596 5997-6000 DT denotes The
T1597 6001-6010 NN denotes lymphomas
T1598 6011-6015 VB denotes were
T1599 6016-6020 RB denotes also
T1600 6021-6034 VB denotes distinguished
T1601 6035-6037 IN denotes by
T1602 6038-6050 JJ denotes constitutive
T1603 6051-6061 NN denotes activation
T1604 6062-6064 IN denotes of
T1605 6065-6070 NN denotes Stat3
T1606 6071-6074 CC denotes and
T1607 6075-6087 NN denotes deregulation
T1608 6088-6090 IN denotes of
T1609 6091-6094 DT denotes the
T1610 6095-6097 NN denotes Rb
T1611 6098-6102 NN denotes cell
T1612 6103-6108 NN denotes cycle
T1613 6109-6116 NN denotes pathway
T1614 6118-6128 NN denotes Inhibition
T1615 6129-6131 IN denotes of
T1616 6132-6135 DT denotes the
T1617 6136-6144 NN denotes PI3K/Akt
T1618 6144-6145 -COMMA- denotes ,
T1619 6146-6150 NN denotes NFκB
T1620 6150-6151 -COMMA- denotes ,
T1621 6152-6155 CC denotes and
T1622 6156-6161 NN denotes Stat3
T1623 6162-6171 NN denotes signaling
T1624 6172-6180 NN denotes pathways
T1625 6181-6188 VB denotes blocked
T1626 6189-6192 DT denotes the
T1627 6193-6201 VB denotes enhanced
T1628 6202-6208 NN denotes growth
T1629 6209-6211 IN denotes of
T1630 6212-6216 CC denotes both
T1631 6217-6221 NN denotes LMP1
T1632 6222-6232 JJ denotes transgenic
T1633 6233-6236 CC denotes and
T1634 6237-6246 JJ denotes malignant
T1635 6247-6258 NN denotes lymphocytes
T1636 6258-6259 -COMMA- denotes ,
T1637 6260-6270 VB denotes suggesting
T1638 6271-6275 IN denotes that
T1639 6276-6281 DT denotes these
T1640 6282-6290 NN denotes pathways
T1641 6291-6294 VB denotes are
T1642 6295-6303 VB denotes required
T1643 6304-6307 IN denotes for
T1644 6308-6313 PRP-DOLLAR- denotes their
T1645 6314-6320 NN denotes growth
T1646 6321-6324 CC denotes and
T1647 6325-6333 NN denotes survival
T1648 6335-6340 DT denotes These
T1649 6341-6347 VB denotes appear
T1650 6348-6350 TO denotes to
T1651 6351-6353 VB denotes be
T1652 6354-6357 DT denotes the
T1653 6358-6362 JJ denotes same
T1654 6363-6370 NN denotes targets
T1655 6371-6375 WDT denotes that
T1656 6376-6379 VB denotes are
T1657 6380-6391 VB denotes deregulated
T1658 6392-6394 IN denotes in
T1659 6395-6404 JJ denotes wild-type
T1660 6405-6409 NN denotes B-1a
T1661 6410-6419 NN denotes lymphomas
T1662 6420-6424 WDT denotes that
T1663 6425-6430 VB denotes arise
T1664 6431-6444 RB denotes spontaneously
T1665 6445-6452 IN denotes through
T1666 6453-6456 NN denotes age
T1667 6457-6471 NN denotes predisposition
T1668 6473-6477 DT denotes This
T1669 6478-6483 NN denotes study
T1670 6484-6491 VB denotes reveals
T1671 6492-6496 IN denotes that
T1672 6497-6501 NN denotes LMP1
T1673 6502-6510 VB denotes promotes
T1674 6511-6521 NN denotes malignancy
T1675 6522-6524 IN denotes in
T1676 6525-6530 NN denotes cells
T1677 6531-6535 IN denotes with
T1678 6536-6539 DT denotes the
T1679 6540-6548 JJ denotes inherent
T1680 6549-6556 NN denotes ability
T1681 6557-6559 TO denotes to
T1682 6560-6571 VB denotes proliferate
T1683 6572-6575 CC denotes and
T1684 6576-6580 IN denotes that
T1685 6581-6584 DT denotes the
T1686 6585-6588 NN denotes Akt
T1687 6588-6589 -COMMA- denotes ,
T1688 6590-6594 NN denotes NFκB
T1689 6594-6595 -COMMA- denotes ,
T1690 6596-6599 CC denotes and
T1691 6600-6605 NN denotes Stat3
T1692 6606-6615 NN denotes signaling
T1693 6616-6624 NN denotes pathways
T1694 6625-6628 VB denotes are
T1695 6629-6637 VB denotes required
T1696 6638-6641 IN denotes for
T1697 6642-6645 PRP-DOLLAR- denotes its
T1698 6646-6652 NN denotes growth
T1699 6653-6664 JJ denotes stimulatory
T1700 6665-6672 NN denotes effects
T3222 6684-6688 JJ denotes High
T3223 6689-6695 NN denotes Levels
T3224 6696-6698 IN denotes of
T3225 6699-6703 NN denotes LMP1
T3226 6704-6714 NN denotes Expression
T3227 6715-6725 VB denotes Correlates
T3228 6726-6730 IN denotes with
T3229 6731-6734 DT denotes the
T3230 6735-6746 NN denotes Development
T3231 6747-6749 IN denotes of
T3232 6750-6758 NN denotes Lymphoma
T3233 6759-6763 NN denotes LMP1
T3234 6764-6774 NN denotes expression
T3235 6775-6777 IN denotes in
T3236 6778-6784 NN denotes IgLMP1
T3237 6785-6789 NN denotes mice
T3238 6790-6793 VB denotes was
T3239 6794-6802 VB denotes directed
T3240 6803-6805 TO denotes to
T3241 6806-6807 NN denotes B
T3242 6808-6813 NN denotes cells
T3243 6814-6819 IN denotes under
T3244 6820-6823 DT denotes the
T3245 6824-6831 NN denotes control
T3246 6832-6834 IN denotes of
T3247 6835-6838 DT denotes the
T3248 6839-6841 NN denotes Ig
T3249 6842-6847 JJ denotes heavy
T3250 6848-6853 NN denotes chain
T3251 6854-6862 NN denotes promoter
T3252 6863-6866 CC denotes and
T3253 6867-6875 NN denotes enhancer
T3254 6877-6879 PRP denotes It
T3255 6880-6883 VB denotes has
T3256 6884-6894 RB denotes previously
T3257 6895-6899 VB denotes been
T3258 6900-6905 VB denotes shown
T3259 6906-6910 IN denotes that
T3260 6911-6913 IN denotes in
T3261 6914-6919 DT denotes these
T3262 6920-6930 JJ denotes transgenic
T3263 6931-6935 NN denotes mice
T3264 6935-6936 -COMMA- denotes ,
T3265 6937-6941 NN denotes LMP1
T3266 6942-6952 NN denotes expression
T3267 6953-6956 VB denotes was
T3268 6957-6967 JJ denotes restricted
T3269 6968-6970 TO denotes to
T3270 6971-6976 JJ denotes B220+
T3271 6977-6978 NN denotes B
T3272 6979-6984 NN denotes cells
T3273 6985-6989 IN denotes with
T3274 6990-6998 NN denotes lymphoma
T3275 6999-7007 VB denotes detected
T3276 7008-7010 IN denotes in
T3277 7011-7018 RB denotes greatly
T3278 7019-7027 VB denotes enlarged
T3279 7028-7035 NN denotes spleens
T3280 7036-7037 -LRB- denotes [
T3281 7037-7042 CD denotes 23,26
T3282 7042-7043 -RRB- denotes ]
T3283 7045-7047 TO denotes To
T3284 7048-7059 VB denotes investigate
T3285 7060-7067 IN denotes whether
T3286 7068-7072 NN denotes LMP1
T3287 7073-7083 NN denotes expression
T3288 7084-7095 VB denotes contributes
T3289 7096-7098 TO denotes to
T3290 7099-7107 NN denotes lymphoma
T3291 7108-7119 NN denotes development
T3292 7119-7120 -COMMA- denotes ,
T3293 7121-7122 NN denotes B
T3294 7123-7128 NN denotes cells
T3295 7129-7133 VB denotes were
T3296 7134-7142 VB denotes purified
T3297 7143-7147 IN denotes from
T3298 7148-7159 NN denotes splenocytes
T3299 7160-7162 IN denotes by
T3300 7163-7171 JJ denotes positive
T3301 7172-7181 NN denotes selection
T3302 7182-7187 VB denotes using
T3303 7188-7197 JJ denotes anti-CD19
T3304 7198-7202 NN denotes MACS
T3305 7203-7211 JJ denotes magnetic
T3306 7212-7217 NN denotes beads
T3307 7217-7218 -COMMA- denotes ,
T3308 7219-7222 CC denotes and
T3309 7223-7233 JJ denotes equivalent
T3310 7234-7241 NN denotes amounts
T3311 7242-7244 IN denotes of
T3312 7245-7246 NN denotes B
T3313 7247-7252 NN denotes cells
T3314 7253-7257 VB denotes were
T3315 7258-7266 VB denotes analyzed
T3316 7267-7269 IN denotes by
T3317 7270-7284 NN denotes immunoblotting
T3318 7286-7290 NN denotes LMP1
T3319 7291-7294 VB denotes was
T3320 7295-7305 JJ denotes detectable
T3321 7306-7308 IN denotes in
T3322 7309-7313 NN denotes LMP1
T3323 7314-7324 JJ denotes transgenic
T3324 7325-7326 NN denotes B
T3325 7327-7332 NN denotes cells
T3326 7332-7333 -COMMA- denotes ,
T3327 7334-7337 CC denotes but
T3328 7338-7342 IN denotes upon
T3329 7343-7354 NN denotes development
T3330 7355-7357 IN denotes of
T3331 7358-7366 NN denotes lymphoma
T3332 7366-7367 -COMMA- denotes ,
T3333 7368-7372 NN denotes LMP1
T3334 7373-7383 NN denotes expression
T3335 7384-7387 VB denotes was
T3336 7388-7396 JJ denotes stronger
T3337 7397-7399 IN denotes in
T3338 7400-7403 CD denotes 5/7
T3339 7404-7413 NN denotes lymphomas
T3340 7414-7422 VB denotes analyzed
T3341 7423-7427 IN denotes with
T3342 7428-7439 JJ denotes concomitant
T3343 7440-7450 NN denotes appearance
T3344 7451-7453 IN denotes of
T3345 7454-7465 NN denotes degradation
T3346 7466-7474 NN denotes products
T3347 7475-7476 -LRB- denotes (
T3348 7476-7482 NN denotes Figure
T3349 7483-7485 NN denotes 1A
T3350 7485-7486 -RRB- denotes )
T3351 7488-7490 TO denotes To
T3352 7491-7500 VB denotes determine
T3353 7501-7508 IN denotes whether
T3354 7509-7512 DT denotes the
T3355 7513-7519 JJ denotes higher
T3356 7520-7525 NN denotes level
T3357 7526-7528 IN denotes of
T3358 7529-7533 NN denotes LMP1
T3359 7534-7542 VB denotes detected
T3360 7543-7546 VB denotes was
T3361 7547-7550 JJ denotes due
T3362 7551-7553 TO denotes to
T3363 7554-7556 DT denotes an
T3364 7557-7566 NN denotes expansion
T3365 7567-7569 IN denotes of
T3366 7570-7579 JJ denotes malignant
T3367 7580-7591 NN denotes lymphocytes
T3368 7591-7592 -COMMA- denotes ,
T3369 7593-7603 NN denotes expression
T3370 7604-7606 IN denotes of
T3371 7607-7611 NN denotes LMP1
T3372 7612-7614 IN denotes in
T3373 7615-7618 DT denotes the
T3374 7619-7625 NN denotes spleen
T3375 7626-7629 VB denotes was
T3376 7630-7637 RB denotes further
T3377 7638-7647 VB denotes evaluated
T3378 7648-7650 IN denotes by
T3379 7651-7670 JJ denotes immunohistochemical
T3380 7671-7679 NN denotes staining
T3381 7681-7701 NN denotes Immunohistochemistry
T3382 7702-7710 NN denotes analysis
T3383 7711-7713 IN denotes of
T3384 7714-7720 NN denotes spleen
T3385 7721-7729 NN denotes sections
T3386 7730-7738 VB denotes detected
T3387 7739-7743 NN denotes LMP1
T3388 7744-7746 IN denotes in
T3389 7747-7750 DT denotes the
T3390 7751-7757 NN denotes plasma
T3391 7758-7766 NN denotes membrane
T3392 7767-7769 IN denotes of
T3393 7770-7775 NN denotes cells
T3394 7776-7778 IN denotes in
T3395 7779-7783 CC denotes both
T3396 7784-7787 DT denotes the
T3397 7788-7798 JJ denotes follicular
T3398 7799-7804 JJ denotes white
T3399 7805-7809 NN denotes pulp
T3400 7810-7813 CC denotes and
T3401 7814-7825 VB denotes circulating
T3402 7826-7837 NN denotes lymphocytes
T3403 7838-7840 IN denotes in
T3404 7841-7844 DT denotes the
T3405 7845-7848 JJ denotes red
T3406 7849-7853 NN denotes pulp
T3407 7854-7855 -LRB- denotes (
T3408 7855-7861 NN denotes Figure
T3409 7862-7864 NN denotes 1B
T3410 7864-7865 -RRB- denotes )
T3411 7867-7871 NN denotes LMP1
T3412 7872-7882 NN denotes expression
T3413 7883-7886 VB denotes was
T3414 7887-7900 JJ denotes heterogeneous
T3415 7901-7905 IN denotes with
T3416 7906-7912 JJ denotes strong
T3417 7913-7917 NN denotes LMP1
T3418 7918-7926 NN denotes staining
T3419 7927-7939 VB denotes interspersed
T3420 7940-7947 IN denotes amongst
T3421 7948-7949 DT denotes a
T3422 7950-7960 NN denotes background
T3423 7961-7963 IN denotes of
T3424 7964-7969 NN denotes cells
T3425 7970-7978 VB denotes staining
T3426 7979-7985 RB denotes weakly
T3427 7986-7989 IN denotes for
T3428 7990-7994 NN denotes LMP1
T3429 7996-8000 IN denotes Upon
T3430 8001-8012 NN denotes development
T3431 8013-8015 TO denotes to
T3432 8016-8024 NN denotes lymphoma
T3433 8024-8025 -COMMA- denotes ,
T3434 8026-8030 NN denotes LMP1
T3435 8031-8041 NN denotes expression
T3436 8042-8045 VB denotes was
T3437 8046-8050 RB denotes more
T3438 8051-8061 RB denotes abundantly
T3439 8062-8070 VB denotes detected
T3440 8071-8075 IN denotes with
T3441 8076-8084 JJ denotes multiple
T3442 8085-8089 NN denotes foci
T3443 8090-8092 IN denotes of
T3444 8093-8100 JJ denotes intense
T3445 8101-8105 NN denotes LMP1
T3446 8106-8114 NN denotes staining
T3447 8116-8120 DT denotes This
T3448 8121-8133 VB denotes demonstrates
T3449 8134-8138 IN denotes that
T3450 8139-8142 DT denotes the
T3451 8143-8152 VB denotes increased
T3452 8153-8157 NN denotes LMP1
T3453 8158-8166 VB denotes detected
T3454 8167-8169 IN denotes by
T3455 8170-8184 NN denotes immunoblotting
T3456 8185-8189 IN denotes upon
T3457 8190-8199 JJ denotes malignant
T3458 8200-8211 NN denotes progression
T3459 8212-8220 VB denotes reflects
T3460 8221-8223 DT denotes an
T3461 8224-8232 NN denotes increase
T3462 8233-8235 IN denotes in
T3463 8236-8240 NN denotes LMP1
T3464 8241-8251 NN denotes expression
T3465 8252-8255 CC denotes and
T3466 8256-8258 DT denotes an
T3467 8259-8271 NN denotes accumulation
T3468 8272-8274 IN denotes of
T3469 8275-8280 NN denotes cells
T3470 8281-8291 VB denotes expressing
T3471 8292-8296 JJ denotes high
T3472 8297-8303 NN denotes levels
T3473 8304-8306 IN denotes of
T3474 8307-8311 NN denotes LMP1
T3475 8313-8317 DT denotes This
T3476 8318-8329 NN denotes correlation
T3477 8330-8337 IN denotes between
T3478 8338-8342 JJ denotes high
T3479 8343-8347 NN denotes LMP1
T3480 8348-8358 NN denotes expression
T3481 8359-8362 CC denotes and
T3482 8363-8366 DT denotes the
T3483 8367-8378 NN denotes development
T3484 8379-8381 IN denotes of
T3485 8382-8390 NN denotes lymphoma
T3486 8391-8399 VB denotes suggests
T3487 8400-8404 IN denotes that
T3488 8405-8416 NN denotes progression
T3489 8417-8419 TO denotes to
T3490 8420-8428 NN denotes lymphoma
T3491 8429-8436 NN denotes results
T3492 8437-8441 IN denotes from
T3493 8442-8451 VB denotes increased
T3494 8452-8458 NN denotes levels
T3495 8459-8461 IN denotes of
T3496 8462-8466 NN denotes LMP1
T4164 9279-9285 NN denotes chains
T4165 9286-9287 -LRB- denotes (
T4166 9287-9288 UH denotes κ
T4167 9288-9289 -COMMA- denotes ,
T4168 9290-9291 LS denotes λ
T4169 9291-9292 -RRB- denotes )
T4170 9293-9297 VB denotes were
T4171 9298-9306 VB denotes analyzed
T4172 9307-9309 IN denotes by
T4173 9310-9314 NN denotes flow
T4174 9315-9324 NN denotes cytometry
T4175 9326-9333 JJ denotes Similar
T4176 9334-9341 NN denotes numbers
T4177 9342-9344 IN denotes of
T4178 9345-9350 NN denotes naïve
T4179 9351-9352 -LRB- denotes (
T4180 9352-9364 NN denotes IgM+IgD+IgG−
T4181 9364-9365 -RRB- denotes )
T4182 9366-9373 JJ denotes splenic
T4183 9374-9375 NN denotes B
T4184 9376-9381 NN denotes cells
T4185 9382-9386 IN denotes with
T4186 9387-9388 DT denotes a
T4187 9389-9395 JJ denotes strong
T4188 9396-9400 NN denotes bias
T4189 9401-9408 IN denotes towards
T4190 9409-9410 JJ denotes κ
T4191 9411-9416 JJ denotes light
T4192 9417-9422 NN denotes chain
T4193 9423-9427 VB denotes were
T4194 9428-9436 VB denotes detected
T4195 9437-9441 IN denotes from
T4196 9442-9451 JJ denotes wild-type
T4197 9452-9454 CC denotes or
T4198 9455-9459 NN denotes LMP1
T4199 9460-9470 JJ denotes transgenic
T4200 9471-9475 NN denotes mice
T4201 9475-9476 -COMMA- denotes ,
T4202 9477-9487 VB denotes indicating
T4203 9488-9492 IN denotes that
T4204 9493-9497 NN denotes LMP1
T4205 9498-9507 NN denotes signaling
T4206 9508-9512 VB denotes does
T4207 9513-9516 RB denotes not
T4208 9517-9523 VB denotes affect
T4209 9524-9525 NN denotes B
T4210 9526-9530 NN denotes cell
T4211 9531-9541 NN denotes maturation
T4212 9542-9543 -LRB- denotes (
T4213 9543-9554 JJ denotes unpublished
T4214 9555-9559 NN denotes data
T4215 9559-9560 -RRB- denotes )
T4216 9562-9566 NN denotes Flow
T4217 9567-9576 NN denotes cytometry
T4218 9577-9585 NN denotes analysis
T4219 9586-9588 IN denotes of
T4220 9589-9592 DT denotes the
T4221 9593-9606 JJ denotes SCID-passaged
T4222 9607-9616 JJ denotes wild-type
T4223 9617-9620 CC denotes and
T4224 9621-9625 NN denotes LMP1
T4225 9626-9636 JJ denotes transgenic
T4226 9637-9646 NN denotes lymphomas
T4227 9647-9655 VB denotes revealed
T4228 9656-9658 DT denotes an
T4229 9659-9672 NN denotes IgMhighIgDlow
T4230 9673-9682 NN denotes phenotype
T4231 9683-9684 -LRB- denotes (
T4232 9684-9690 NN denotes Figure
T4233 9691-9693 NN denotes 2A
T4234 9693-9694 -RRB- denotes )
T4235 9694-9695 -COMMA- denotes ,
T4236 9696-9706 JJ denotes indicative
T4237 9707-9709 IN denotes of
T4238 9710-9718 JJ denotes marginal
T4239 9719-9723 NN denotes zone
T4240 9723-9724 -COMMA- denotes ,
T4241 9725-9728 NN denotes B-1
T4242 9728-9729 -COMMA- denotes ,
T4243 9730-9732 CC denotes or
T4244 9733-9739 NN denotes memory
T4245 9740-9741 NN denotes B
T4246 9742-9747 NN denotes cells
T4247 9749-9752 NN denotes B-1
T4248 9753-9758 NN denotes cells
T4249 9759-9762 VB denotes are
T4250 9763-9770 RB denotes further
T4251 9771-9780 VB denotes separated
T4252 9781-9785 IN denotes into
T4253 9786-9790 JJ denotes CD5+
T4254 9791-9792 -LRB- denotes (
T4255 9792-9796 NN denotes B-1a
T4256 9796-9797 -RRB- denotes )
T4257 9798-9801 CC denotes and
T4258 9802-9806 NN denotes CD5−
T4259 9807-9808 -LRB- denotes (
T4260 9808-9812 NN denotes B-1b
T4261 9812-9813 -RRB- denotes )
T4262 9814-9821 NN denotes subsets
T4263 9823-9825 TO denotes To
T4264 9826-9839 VB denotes differentiate
T4265 9840-9847 IN denotes between
T4266 9848-9853 DT denotes these
T4267 9854-9858 NN denotes cell
T4268 9859-9864 NN denotes types
T4269 9864-9865 -COMMA- denotes ,
T4270 9866-9874 NN denotes lymphoma
T4271 9875-9880 NN denotes cells
T4272 9881-9885 VB denotes were
T4273 9886-9893 RB denotes further
T4274 9894-9902 VB denotes analyzed
T4275 9903-9906 IN denotes for
T4276 9907-9910 DT denotes the
T4277 9911-9915 NN denotes B-1a
T4278 9916-9922 NN denotes marker
T4279 9923-9926 NN denotes CD5
T4280 9928-9931 DT denotes All
T4281 9932-9933 -LRB- denotes (
T4282 9933-9936 CD denotes 5/5
T4283 9936-9937 -RRB- denotes )
T4284 9938-9940 IN denotes of
T4285 9941-9944 DT denotes the
T4286 9945-9951 VB denotes tested
T4287 9952-9956 NN denotes LMP1
T4288 9957-9967 JJ denotes transgenic
T4289 9968-9977 NN denotes lymphomas
T4290 9978-9987 VB denotes displayed
T4291 9988-9990 DT denotes an
T4292 9991-10008 JJ denotes IgMhighIgDlowCD5+
T4293 10009-10018 NN denotes phenotype
T4294 10019-10020 -LRB- denotes (
T4295 10020-10026 NN denotes Figure
T4296 10027-10029 NN denotes 2A
T4297 10029-10030 -RRB- denotes )
T4298 10030-10031 -COMMA- denotes ,
T4299 10032-10034 DT denotes an
T4300 10035-10045 NN denotes expression
T4301 10046-10053 NN denotes pattern
T4302 10054-10058 WDT denotes that
T4303 10059-10072 VB denotes distinguishes
T4304 10073-10077 NN denotes B-1a
T4305 10078-10083 NN denotes cells
T4306 10085-10098 RB denotes Interestingly
T4307 10098-10099 -COMMA- denotes ,
T4308 10100-10101 DT denotes a
T4309 10102-10113 JJ denotes spontaneous
T4310 10114-10123 JJ denotes wild-type
T4311 10124-10132 NN denotes lymphoma
T4312 10133-10137 RB denotes also
T4313 10138-10147 VB denotes developed
T4314 10148-10150 IN denotes in
T4315 10151-10155 NN denotes B-1a
T4316 10156-10161 NN denotes cells
T4317 10162-10163 -LRB- denotes (
T4318 10163-10169 NN denotes Figure
T4319 10170-10172 NN denotes 2A
T4320 10172-10173 -RRB- denotes )
T4321 10175-10180 DT denotes These
T4322 10181-10186 NN denotes cells
T4323 10187-10190 VB denotes are
T4324 10191-10193 DT denotes an
T4325 10194-10205 JJ denotes interesting
T4326 10206-10216 NN denotes population
T4327 10217-10221 WDT denotes that
T4328 10222-10224 VB denotes is
T4329 10225-10229 PRP denotes self
T4330 10230-10242 VB denotes replenishing
T4331 10243-10247 IN denotes with
T4332 10248-10250 DT denotes an
T4333 10251-10260 VB denotes increased
T4334 10261-10271 NN denotes likelihood
T4335 10272-10274 TO denotes to
T4336 10275-10281 VB denotes become
T4337 10282-10291 JJ denotes malignant
T4338 10292-10294 IN denotes in
T4339 10295-10299 JJ denotes aged
T4340 10300-10304 NN denotes mice
T4341 10305-10306 -LRB- denotes [
T4342 10306-10308 CD denotes 30
T4343 10308-10309 -RRB- denotes ]
T4344 10311-10319 NN denotes Analysis
T4345 10320-10322 IN denotes of
T4346 10323-10327 NN denotes LMP1
T4347 10328-10338 JJ denotes transgenic
T4348 10339-10343 NN denotes mice
T4349 10344-10350 IN denotes before
T4350 10351-10354 DT denotes the
T4351 10355-10366 NN denotes development
T4352 10367-10369 IN denotes of
T4353 10370-10378 NN denotes lymphoma
T4354 10379-10385 VB denotes showed
T4355 10386-10393 JJ denotes similar
T4356 10394-10401 NN denotes numbers
T4357 10402-10404 IN denotes of
T4358 10405-10412 JJ denotes splenic
T4359 10413-10417 NN denotes B-1a
T4360 10418-10419 -LRB- denotes (
T4361 10419-10428 JJ denotes CD19+CD5+
T4362 10428-10429 -RRB- denotes )
T4363 10430-10433 CC denotes and
T4364 10434-10438 NN denotes B-1b
T4365 10439-10441 CC denotes or
T4366 10442-10445 NN denotes B-2
T4367 10446-10457 NN denotes populations
T4368 10458-10459 -LRB- denotes (
T4369 10459-10468 NN denotes CD19+CD5−
T4370 10468-10469 -RRB- denotes )
T4371 10469-10470 -COMMA- denotes ,
T4372 10471-10481 VB denotes indicating
T4373 10482-10486 IN denotes that
T4374 10487-10491 NN denotes LMP1
T4375 10492-10496 VB denotes does
T4376 10497-10500 RB denotes not
T4377 10501-10507 VB denotes affect
T4378 10508-10509 NN denotes B
T4379 10510-10514 NN denotes cell
T4380 10515-10530 NN denotes differentiation
T4381 10531-10532 -LRB- denotes (
T4382 10532-10538 NN denotes Figure
T4383 10539-10541 NN denotes 2B
T4384 10541-10542 -RRB- denotes )
T4385 11525-11528 JJ denotes Due
T4386 11529-11531 TO denotes to
T4387 11532-11539 JJ denotes allelic
T4388 11540-11549 NN denotes exclusion
T4389 11549-11550 -COMMA- denotes ,
T4390 11551-11557 JJ denotes mature
T4391 11558-11559 NN denotes B
T4392 11560-11565 NN denotes cells
T4393 11566-11570 WDT denotes that
T4394 11571-11575 VB denotes have
T4395 11576-11580 VB denotes been
T4396 11581-11588 VB denotes exposed
T4397 11589-11591 TO denotes to
T4398 11592-11599 NN denotes antigen
T4399 11600-11604 MD denotes will
T4400 11605-11614 RB denotes typically
T4401 11615-11622 VB denotes express
T4402 11623-11627 RB denotes only
T4403 11628-11631 CD denotes one
T4404 11632-11637 JJ denotes heavy
T4405 11638-11643 NN denotes chain
T4406 11644-11651 NN denotes isotype
T4407 11652-11653 -LRB- denotes (
T4408 11653-11656 NN denotes IgG
T4409 11656-11657 -COMMA- denotes ,
T4410 11658-11661 NN denotes IgE
T4411 11661-11662 -COMMA- denotes ,
T4412 11663-11665 CC denotes or
T4413 11666-11669 NN denotes IgA
T4414 11669-11670 -RRB- denotes )
T4415 11671-11674 CC denotes and
T4416 11675-11681 CC denotes either
T4417 11682-11683 DT denotes a
T4418 11684-11685 NN denotes κ
T4419 11686-11688 CC denotes or
T4420 11689-11690 VB denotes λ
T4421 11691-11696 JJ denotes light
T4422 11697-11702 NN denotes chain
T4423 11704-11717 RB denotes Interestingly
T4424 11717-11718 -COMMA- denotes ,
T4425 11719-11722 CD denotes 2/5
T4426 11723-11727 NN denotes LMP1
T4427 11728-11738 JJ denotes transgenic
T4428 11739-11748 NN denotes lymphomas
T4429 11749-11757 VB denotes analyzed
T4430 11758-11759 -LRB- denotes (
T4431 11759-11768 NN denotes lymphomas
T4432 11769-11770 CD denotes 2
T4433 11771-11774 CC denotes and
T4434 11775-11776 CD denotes 4
T4435 11776-11777 -RRB- denotes )
T4436 11778-11782 VB denotes were
T4437 11783-11789 RB denotes doubly
T4438 11790-11798 JJ denotes positive
T4439 11799-11802 IN denotes for
T4440 11803-11806 JJ denotes low
T4441 11807-11813 NN denotes levels
T4442 11814-11816 IN denotes of
T4443 11817-11821 CC denotes both
T4444 11822-11823 NN denotes κ
T4445 11824-11827 CC denotes and
T4446 11828-11829 VB denotes λ
T4447 11830-11835 JJ denotes light
T4448 11836-11842 NN denotes chains
T4449 11843-11844 -LRB- denotes (
T4450 11844-11850 NN denotes Figure
T4451 11851-11853 NN denotes 2A
T4452 11853-11854 -RRB- denotes )
T4453 11856-11864 JJ denotes Previous
T4454 11865-11881 NN denotes characterization
T4455 11882-11884 IN denotes of
T4456 11885-11888 DT denotes the
T4457 11889-11893 NN denotes LMP1
T4458 11894-11903 NN denotes lymphomas
T4459 11904-11907 VB denotes had
T4460 11908-11916 VB denotes revealed
T4461 11917-11921 IN denotes that
T4462 11922-11925 DT denotes the
T4463 11926-11935 NN denotes lymphomas
T4464 11936-11940 VB denotes were
T4465 11941-11947 JJ denotes clonal
T4466 11948-11950 IN denotes as
T4467 11951-11961 VB denotes determined
T4468 11962-11964 IN denotes by
T4469 11965-11967 NN denotes Ig
T4470 11968-11973 JJ denotes heavy
T4471 11974-11979 NN denotes chain
T4472 11980-11993 NN denotes rearrangement
T4473 11994-11995 -LRB- denotes [
T4474 11995-11997 CD denotes 26
T4475 11997-11998 -RRB- denotes ]
T4476 11998-11999 -COMMA- denotes ,
T4477 12000-12003 CC denotes and
T4478 12004-12012 NN denotes analysis
T4479 12013-12015 IN denotes of
T4480 12016-12017 NN denotes κ
T4481 12018-12023 NN denotes chain
T4482 12024-12037 NN denotes rearrangement
T4483 12038-12039 -LRB- denotes (
T4484 12039-12045 NN denotes Figure
T4485 12046-12048 NN denotes S1
T4486 12048-12049 -RRB- denotes )
T4487 12050-12052 IN denotes of
T4488 12053-12056 DT denotes the
T4489 12057-12064 NN denotes samples
T4490 12065-12073 VB denotes analyzed
T4491 12074-12076 IN denotes in
T4492 12077-12081 DT denotes this
T4493 12082-12087 NN denotes study
T4494 12088-12097 VB denotes confirmed
T4495 12098-12107 NN denotes clonality
T4496 12109-12111 TO denotes To
T4497 12112-12119 RB denotes further
T4498 12120-12126 VB denotes assess
T4499 12127-12132 JJ denotes light
T4500 12133-12138 NN denotes chain
T4501 12139-12149 NN denotes expression
T4502 12149-12150 -COMMA- denotes ,
T4503 12151-12154 DT denotes the
T4504 12155-12163 VB denotes passaged
T4505 12164-12171 NN denotes samples
T4506 12172-12176 VB denotes were
T4507 12177-12183 VB denotes tested
T4508 12184-12186 IN denotes by
T4509 12187-12201 VB denotes immunoblotting
T4510 12202-12205 IN denotes for
T4511 12206-12207 NN denotes κ
T4512 12208-12211 CC denotes and
T4513 12212-12213 VB denotes λ
T4514 12214-12219 JJ denotes light
T4515 12220-12226 NN denotes chains
T4516 12227-12228 -LRB- denotes (
T4517 12228-12234 NN denotes Figure
T4518 12235-12237 NN denotes 2C
T4519 12237-12238 -RRB- denotes )
T4520 12240-12253 RB denotes Interestingly
T4521 12253-12254 -COMMA- denotes ,
T4522 12255-12259 RB denotes very
T4523 12260-12263 JJ denotes low
T4524 12264-12270 NN denotes levels
T4525 12271-12273 IN denotes of
T4526 12274-12284 NN denotes expression
T4527 12285-12287 IN denotes of
T4528 12288-12292 CC denotes both
T4529 12293-12298 JJ denotes light
T4530 12299-12305 NN denotes chains
T4531 12306-12310 VB denotes were
T4532 12311-12319 VB denotes detected
T4533 12320-12322 IN denotes by
T4534 12323-12327 NN denotes flow
T4535 12328-12337 NN denotes cytometry
T4536 12339-12342 DT denotes The
T4537 12343-12346 JJ denotes low
T4538 12347-12353 NN denotes levels
T4539 12354-12356 IN denotes of
T4540 12357-12367 NN denotes expression
T4541 12368-12371 MD denotes may
T4542 12372-12379 VB denotes reflect
T4543 12380-12381 DT denotes a
T4544 12382-12392 NN denotes limitation
T4545 12393-12395 IN denotes of
T4546 12396-12399 DT denotes the
T4547 12400-12405 JJ denotes total
T4548 12406-12412 NN denotes number
T4549 12413-12415 IN denotes of
T4550 12416-12421 JJ denotes light
T4551 12422-12428 NN denotes chains
T4552 12429-12433 WDT denotes that
T4553 12434-12437 MD denotes can
T4554 12438-12440 VB denotes be
T4555 12441-12450 VB denotes expressed
T4556 12451-12453 IN denotes on
T4557 12454-12457 DT denotes the
T4558 12458-12465 NN denotes surface
T4559 12466-12468 IN denotes of
T4560 12469-12470 DT denotes a
T4561 12471-12472 NN denotes B
T4562 12473-12477 NN denotes cell
T4563 12479-12481 IN denotes In
T4564 12482-12491 NN denotes agreement
T4565 12492-12496 IN denotes with
T4566 12497-12500 DT denotes the
T4567 12501-12505 NN denotes flow
T4568 12506-12515 NN denotes cytometry
T4569 12516-12524 NN denotes analysis
T4570 12524-12525 -COMMA- denotes ,
T4571 12526-12530 NN denotes LMP1
T4572 12531-12541 JJ denotes transgenic
T4573 12542-12551 NN denotes lymphomas
T4574 12552-12553 CD denotes 2
T4575 12554-12557 CC denotes and
T4576 12558-12559 CD denotes 4
T4577 12560-12564 VB denotes were
T4578 12565-12569 RB denotes also
T4579 12570-12578 JJ denotes positive
T4580 12579-12582 IN denotes for
T4581 12583-12584 NN denotes κ
T4582 12585-12588 CC denotes and
T4583 12589-12590 VB denotes λ
T4584 12591-12596 JJ denotes light
T4585 12597-12603 NN denotes chains
T4586 12604-12606 IN denotes by
T4587 12607-12617 NN denotes immunoblot
T4588 12618-12626 NN denotes analysis
T4589 12627-12628 -LRB- denotes (
T4590 12628-12634 NN denotes Figure
T4591 12635-12637 NN denotes 2C
T4592 12637-12638 -RRB- denotes )
T4593 12638-12639 -COMMA- denotes ,
T4594 12640-12650 VB denotes confirming
T4595 12651-12655 IN denotes that
T4596 12656-12661 DT denotes these
T4597 12662-12671 NN denotes lymphomas
T4598 12672-12679 VB denotes express
T4599 12680-12684 DT denotes both
T4600 12685-12690 JJ denotes light
T4601 12691-12697 NN denotes chains
T4602 12699-12700 DT denotes A
T4603 12701-12709 JJ denotes previous
T4604 12710-12715 NN denotes study
T4605 12716-12718 IN denotes of
T4606 12719-12723 NN denotes mice
T4607 12724-12728 WDT denotes that
T4608 12729-12738 VB denotes developed
T4609 12739-12747 NN denotes leukemia
T4610 12748-12751 JJ denotes due
T4611 12752-12754 TO denotes to
T4612 12755-12757 DT denotes an
T4613 12758-12767 NN denotes expansion
T4614 12768-12770 IN denotes of
T4615 12771-12784 JJ denotes self-reactive
T4616 12785-12789 NN denotes B-1a
T4617 12790-12795 NN denotes cells
T4618 12796-12806 VB denotes determined
T4619 12807-12811 IN denotes that
T4620 12812-12815 DT denotes the
T4621 12816-12820 NN denotes B-1a
T4622 12821-12830 NN denotes leukemias
T4623 12831-12835 VB denotes were
T4624 12836-12840 RB denotes also
T4625 12841-12847 RB denotes doubly
T4626 12848-12856 JJ denotes positive
T4627 12857-12860 IN denotes for
T4628 12861-12862 NN denotes κ
T4629 12863-12866 CC denotes and
T4630 12867-12868 VB denotes λ
T4631 12869-12874 JJ denotes light
T4632 12875-12881 NN denotes chains
T4633 12882-12883 -LRB- denotes [
T4634 12883-12885 CD denotes 31
T4635 12885-12886 -RRB- denotes ]
T4636 12888-12893 DT denotes These
T4637 12894-12902 NN denotes findings
T4638 12903-12911 VB denotes indicate
T4639 12912-12916 IN denotes that
T4640 12917-12927 NN denotes expression
T4641 12928-12930 IN denotes of
T4642 12931-12935 NN denotes LMP1
T4643 12936-12938 IN denotes in
T4644 12939-12943 NN denotes B-1a
T4645 12944-12949 NN denotes cells
T4646 12950-12958 VB denotes promotes
T4647 12959-12962 DT denotes the
T4648 12963-12974 NN denotes development
T4649 12975-12977 IN denotes of
T4650 12978-12988 NN denotes malignancy
T4651 12989-12992 CC denotes and
T4652 12993-12996 MD denotes can
T4653 12997-13003 VB denotes result
T4654 13004-13006 IN denotes in
T4655 13007-13010 DT denotes the
T4656 13011-13019 JJ denotes aberrant
T4657 13020-13026 NN denotes escape
T4658 13027-13031 IN denotes from
T4659 13032-13039 JJ denotes allelic
T4660 13040-13049 NN denotes exclusion
T5547 13052-13056 NN denotes LMP1
T5548 13057-13065 VB denotes Promotes
T5549 13066-13067 NN denotes B
T5550 13068-13072 NN denotes Cell
T5551 13073-13081 NN denotes Survival
T5552 13082-13085 CC denotes and
T5553 13086-13099 NN denotes Proliferation
T5554 13100-13102 IN denotes In
T5555 13103-13108 NNP denotes Vitro
T5556 13109-13116 JJ denotes Primary
T5557 13117-13118 NN denotes B
T5558 13119-13123 NN denotes cell
T5559 13124-13132 NN denotes cultures
T5560 13133-13136 MD denotes can
T5561 13137-13139 VB denotes be
T5562 13140-13150 VB denotes maintained
T5563 13151-13158 IN denotes through
T5564 13159-13163 NN denotes CD40
T5565 13164-13172 NN denotes ligation
T5566 13173-13176 CC denotes and
T5567 13177-13192 NN denotes supplementation
T5568 13193-13197 IN denotes with
T5569 13198-13201 NN denotes IL4
T5570 13202-13203 -LRB- denotes [
T5571 13203-13205 CD denotes 32
T5572 13205-13206 -RRB- denotes ]
T5573 13208-13210 TO denotes To
T5574 13211-13222 VB denotes investigate
T5575 13223-13230 IN denotes whether
T5576 13231-13235 NN denotes LMP1
T5577 13236-13243 VB denotes affects
T5578 13244-13251 JJ denotes primary
T5579 13252-13253 NN denotes B
T5580 13254-13258 NN denotes cell
T5581 13259-13267 NN denotes survival
T5582 13268-13271 CC denotes and
T5583 13272-13285 NN denotes proliferation
T5584 13285-13286 -COMMA- denotes ,
T5585 13287-13298 NN denotes splenocytes
T5586 13299-13303 VB denotes were
T5587 13304-13312 VB denotes cultured
T5588 13313-13315 IN denotes in
T5589 13316-13319 DT denotes the
T5590 13320-13328 NN denotes presence
T5591 13329-13331 CC denotes or
T5592 13332-13339 NN denotes absence
T5593 13340-13342 IN denotes of
T5594 13343-13346 NN denotes IL4
T5595 13347-13350 CC denotes and
T5596 13351-13359 VB denotes analyzed
T5597 13360-13362 IN denotes by
T5598 13363-13366 NN denotes MTS
T5599 13367-13369 IN denotes as
T5600 13370-13371 DT denotes a
T5601 13372-13381 JJ denotes metabolic
T5602 13382-13388 NN denotes marker
T5603 13388-13389 -COMMA- denotes ,
T5604 13390-13392 IN denotes by
T5605 13393-13401 NN denotes ethidium
T5606 13402-13411 NN denotes monoazide
T5607 13412-13413 -LRB- denotes (
T5608 13413-13416 NN denotes EMA
T5609 13416-13417 -RRB- denotes )
T5610 13418-13427 NN denotes exclusion
T5611 13428-13431 IN denotes for
T5612 13432-13441 NN denotes viability
T5613 13441-13442 -COMMA- denotes ,
T5614 13443-13446 CC denotes and
T5615 13447-13449 IN denotes by
T5616 13450-13474 NN denotes 5-bromo-2′-deoxy-uridine
T5617 13475-13476 -LRB- denotes (
T5618 13476-13480 NN denotes BrdU
T5619 13480-13481 -RRB- denotes )
T5620 13482-13495 NN denotes incorporation
T5621 13496-13499 IN denotes for
T5622 13500-13513 NN denotes proliferation
T5623 13515-13517 IN denotes In
T5624 13518-13521 DT denotes the
T5625 13522-13525 NN denotes MTS
T5626 13526-13531 NN denotes assay
T5627 13531-13532 -COMMA- denotes ,
T5628 13533-13535 IN denotes as
T5629 13536-13544 VB denotes expected
T5630 13544-13545 -COMMA- denotes ,
T5631 13546-13557 NN denotes splenocytes
T5632 13558-13562 IN denotes from
T5633 13563-13572 JJ denotes wild-type
T5634 13573-13577 NN denotes mice
T5635 13578-13581 VB denotes did
T5636 13582-13585 RB denotes not
T5637 13586-13593 VB denotes survive
T5638 13594-13598 RB denotes even
T5639 13599-13603 IN denotes with
T5640 13604-13607 DT denotes the
T5641 13608-13616 NN denotes addition
T5642 13617-13619 IN denotes of
T5643 13620-13623 NN denotes IL4
T5644 13624-13627 JJ denotes due
T5645 13628-13630 TO denotes to
T5646 13631-13632 DT denotes a
T5647 13633-13637 NN denotes lack
T5648 13638-13640 IN denotes of
T5649 13641-13645 NN denotes CD40
T5650 13646-13654 NN denotes ligation
T5651 13655-13656 -LRB- denotes (
T5652 13656-13662 NN denotes Figure
T5653 13663-13665 NN denotes 3A
T5654 13665-13666 -RRB- denotes )
T5655 13668-13670 IN denotes In
T5656 13671-13679 NN denotes contrast
T5657 13679-13680 -COMMA- denotes ,
T5658 13681-13685 NN denotes LMP1
T5659 13686-13697 NN denotes splenocytes
T5660 13698-13701 VB denotes had
T5661 13702-13711 VB denotes increased
T5662 13712-13722 NN denotes metabolism
T5663 13723-13727 RB denotes even
T5664 13728-13730 IN denotes in
T5665 13731-13734 DT denotes the
T5666 13735-13742 NN denotes absence
T5667 13743-13745 IN denotes of
T5668 13746-13749 NN denotes IL4
T5669 13749-13750 -COMMA- denotes ,
T5670 13751-13756 WDT denotes which
T5671 13757-13760 VB denotes was
T5672 13761-13768 RB denotes further
T5673 13769-13777 VB denotes enhanced
T5674 13778-13782 IN denotes upon
T5675 13783-13791 NN denotes addition
T5676 13792-13794 IN denotes of
T5677 13795-13798 NN denotes IL4
T5678 13800-13809 JJ denotes Wild-type
T5679 13810-13813 CC denotes and
T5680 13814-13818 NN denotes LMP1
T5681 13819-13829 JJ denotes transgenic
T5682 13830-13838 NN denotes lymphoma
T5683 13839-13844 NN denotes cells
T5684 13845-13848 VB denotes had
T5685 13849-13853 JJ denotes high
T5686 13854-13860 NN denotes levels
T5687 13861-13863 IN denotes of
T5688 13864-13867 NN denotes MTS
T5689 13868-13876 NN denotes activity
T5690 13877-13881 RB denotes even
T5691 13882-13884 IN denotes in
T5692 13885-13888 DT denotes the
T5693 13889-13896 NN denotes absence
T5694 13897-13899 IN denotes of
T5695 13900-13903 NN denotes IL4
T5696 13904-13905 -LRB- denotes (
T5697 13905-13911 NN denotes Figure
T5698 13912-13914 NN denotes 3A
T5699 13914-13915 -RRB- denotes )
T5700 13917-13920 DT denotes The
T5701 13921-13925 NN denotes LMP1
T5702 13926-13936 JJ denotes transgenic
T5703 13937-13945 NN denotes lymphoma
T5704 13946-13951 NN denotes cells
T5705 13952-13955 VB denotes had
T5706 13956-13969 RB denotes approximately
T5707 13970-13976 RB denotes 4-fold
T5708 13977-13983 JJ denotes higher
T5709 13984-13987 NN denotes MTS
T5710 13988-13996 NN denotes activity
T5711 13997-14001 IN denotes than
T5712 14002-14005 DT denotes the
T5713 14006-14012 JJ denotes normal
T5714 14013-14023 JJ denotes transgenic
T5715 14024-14035 NN denotes lymphocytes
T5716 14036-14039 CC denotes and
T5717 14040-14044 VB denotes were
T5718 14045-14047 IN denotes at
T5719 14048-14053 JJ denotes least
T5720 14054-14060 RB denotes 2-fold
T5721 14061-14067 JJ denotes higher
T5722 14068-14072 IN denotes than
T5723 14073-14076 DT denotes the
T5724 14077-14084 NN denotes control
T5725 14085-14093 NN denotes lymphoma
T5726 14095-14097 IN denotes As
T5727 14098-14108 RB denotes previously
T5728 14109-14118 VB denotes published
T5729 14118-14119 -COMMA- denotes ,
T5730 14120-14128 NN denotes lymphoma
T5731 14129-14136 RB denotes usually
T5732 14137-14145 VB denotes develops
T5733 14146-14148 IN denotes in
T5734 14149-14153 NN denotes mice
T5735 14154-14158 IN denotes over
T5736 14159-14161 CD denotes 12
T5737 14162-14164 NN denotes mo
T5738 14165-14167 IN denotes of
T5739 14168-14171 NN denotes age
T5740 14172-14175 CC denotes and
T5741 14176-14179 DT denotes all
T5742 14180-14184 NN denotes mice
T5743 14185-14188 VB denotes are
T5744 14189-14199 VB denotes sacrificed
T5745 14200-14202 IN denotes by
T5746 14203-14208 CD denotes 18–20
T5747 14209-14211 NN denotes mo
T5748 14213-14216 DT denotes The
T5749 14217-14221 NN denotes ages
T5750 14222-14224 IN denotes of
T5751 14225-14228 DT denotes the
T5752 14229-14239 JJ denotes transgenic
T5753 14240-14244 NN denotes mice
T5754 14245-14249 IN denotes with
T5755 14250-14252 CC denotes or
T5756 14253-14260 IN denotes without
T5757 14261-14269 NN denotes lymphoma
T5758 14270-14276 VB denotes ranged
T5759 14277-14284 IN denotes between
T5760 14285-14286 CD denotes 6
T5761 14287-14290 CC denotes and
T5762 14291-14293 CD denotes 20
T5763 14294-14296 NN denotes mo
T5764 14297-14300 JJ denotes old
T5765 14302-14307 EX denotes There
T5766 14308-14311 VB denotes was
T5767 14312-14314 DT denotes no
T5768 14315-14326 NN denotes correlation
T5769 14327-14334 IN denotes between
T5770 14335-14338 NN denotes age
T5771 14339-14342 CC denotes and
T5772 14343-14346 NN denotes MTS
T5773 14347-14355 NN denotes activity
T5774 15272-15275 NN denotes EMA
T5775 15276-15285 NN denotes exclusion
T5776 15286-15288 IN denotes of
T5777 15289-15294 JJ denotes CD19+
T5778 15295-15300 VB denotes gated
T5779 15301-15302 NN denotes B
T5780 15303-15308 NN denotes cells
T5781 15309-15317 VB denotes prepared
T5782 15318-15322 IN denotes from
T5783 15323-15326 CD denotes two
T5784 15327-15336 JJ denotes wild-type
T5785 15337-15340 CC denotes and
T5786 15341-15344 CD denotes two
T5787 15345-15349 NN denotes LMP1
T5788 15350-15360 JJ denotes transgenic
T5789 15361-15365 NN denotes mice
T5790 15366-15375 VB denotes indicated
T5791 15376-15377 DT denotes a
T5792 15378-15384 JJ denotes 2-fold
T5793 15385-15393 NN denotes increase
T5794 15394-15396 IN denotes in
T5795 15397-15406 NN denotes viability
T5796 15407-15409 IN denotes in
T5797 15410-15413 DT denotes the
T5798 15414-15418 NN denotes LMP1
T5799 15419-15429 JJ denotes transgenic
T5800 15430-15441 NN denotes lymphocytes
T5801 15442-15450 VB denotes compared
T5802 15451-15453 TO denotes to
T5803 15454-15463 JJ denotes wild-type
T5804 15464-15475 NN denotes lymphocytes
T5805 15477-15480 CD denotes Two
T5806 15481-15489 NN denotes examples
T5807 15490-15492 IN denotes of
T5808 15493-15497 NN denotes LMP1
T5809 15498-15508 JJ denotes transgenic
T5810 15509-15517 NN denotes lymphoma
T5811 15518-15523 NN denotes cells
T5812 15524-15527 VB denotes had
T5813 15528-15535 RB denotes greatly
T5814 15536-15545 VB denotes increased
T5815 15546-15555 NN denotes viability
T5816 15556-15560 WDT denotes that
T5817 15561-15564 VB denotes was
T5818 15565-15568 RB denotes not
T5819 15569-15578 VB denotes increased
T5820 15579-15581 IN denotes by
T5821 15582-15585 NN denotes IL4
T5822 15586-15595 NN denotes treatment
T5823 15595-15596 -COMMA- denotes ,
T5824 15597-15607 VB denotes indicating
T5825 15608-15612 IN denotes that
T5826 15613-15616 DT denotes the
T5827 15617-15625 NN denotes lymphoma
T5828 15626-15631 NN denotes cells
T5829 15632-15635 VB denotes are
T5830 15636-15647 JJ denotes independent
T5831 15648-15650 IN denotes of
T5832 15651-15654 NN denotes IL4
T5833 15655-15669 NN denotes co-stimulation
T5834 15670-15671 -LRB- denotes (
T5835 15671-15677 NN denotes Figure
T5836 15678-15680 NN denotes 3B
T5837 15680-15681 -RRB- denotes )
T5838 15683-15694 NN denotes Enhancement
T5839 15695-15697 IN denotes in
T5840 15698-15701 NN denotes MTS
T5841 15702-15710 NN denotes activity
T5842 15711-15714 VB denotes was
T5843 15715-15723 VB denotes observed
T5844 15724-15726 IN denotes in
T5845 15727-15731 NN denotes LMP1
T5846 15732-15742 JJ denotes transgenic
T5847 15743-15751 NN denotes lymphoma
T5848 15752-15757 NN denotes cells
T5849 15758-15760 IN denotes by
T5850 15761-15764 DT denotes the
T5851 15765-15773 NN denotes addition
T5852 15774-15776 IN denotes of
T5853 15777-15780 NN denotes IL4
T5854 15780-15781 -COLON- denotes ;
T5855 15782-15789 RB denotes however
T5856 15789-15790 -COMMA- denotes ,
T5857 15791-15794 NN denotes EMA
T5858 15795-15804 NN denotes exclusion
T5859 15805-15808 VB denotes did
T5860 15809-15812 RB denotes not
T5861 15813-15819 VB denotes reveal
T5862 15820-15821 DT denotes a
T5863 15822-15829 JJ denotes similar
T5864 15830-15838 NN denotes increase
T5865 15840-15844 DT denotes This
T5866 15845-15850 MD denotes could
T5867 15851-15858 VB denotes reflect
T5868 15859-15860 DT denotes a
T5869 15861-15871 NN denotes difference
T5870 15872-15875 IN denotes for
T5871 15876-15879 NN denotes IL4
T5872 15880-15891 NN denotes requirement
T5873 15892-15894 IN denotes in
T5874 15895-15898 DT denotes the
T5875 15899-15908 JJ denotes metabolic
T5876 15909-15917 NN denotes activity
T5877 15918-15924 IN denotes versus
T5878 15925-15928 DT denotes the
T5879 15929-15938 NN denotes viability
T5880 15939-15941 IN denotes of
T5881 15942-15946 NN denotes LMP1
T5882 15947-15957 JJ denotes transgenic
T5883 15958-15966 NN denotes lymphoma
T5884 15967-15972 NN denotes cells
T5885 15974-15982 IN denotes Although
T5886 15983-15993 NN denotes expression
T5887 15994-15996 IN denotes of
T5888 15997-16001 NN denotes LMP1
T5889 16002-16007 MD denotes could
T5890 16008-16015 VB denotes enhance
T5891 16016-16024 NN denotes survival
T5892 16025-16027 IN denotes of
T5893 16028-16041 JJ denotes non-malignant
T5894 16042-16049 JJ denotes primary
T5895 16050-16061 NN denotes lymphocytes
T5896 16061-16062 -COMMA- denotes ,
T5897 16063-16067 NNP denotes BrdU
T5898 16068-16081 NN denotes incorporation
T5899 16082-16090 VB denotes revealed
T5900 16091-16095 IN denotes that
T5901 16096-16100 NN denotes LMP1
T5902 16101-16111 NN denotes expression
T5903 16112-16117 RB denotes alone
T5904 16118-16121 VB denotes was
T5905 16122-16125 RB denotes not
T5906 16126-16136 JJ denotes sufficient
T5907 16137-16139 TO denotes to
T5908 16140-16146 VB denotes induce
T5909 16147-16160 NN denotes proliferation
T5910 16161-16163 IN denotes in
T5911 16164-16171 NN denotes culture
T5912 16172-16173 -LRB- denotes (
T5913 16173-16184 JJ denotes unpublished
T5914 16185-16189 NN denotes data
T5915 16189-16190 -RRB- denotes )
T5916 16192-16196 RB denotes Only
T5917 16197-16205 NN denotes lymphoma
T5918 16206-16211 NN denotes cells
T5919 16212-16215 VB denotes had
T5920 16216-16226 JJ denotes detectable
T5921 16227-16233 NN denotes levels
T5922 16234-16236 IN denotes of
T5923 16237-16241 NN denotes BrdU
T5924 16242-16255 NN denotes incorporation
T5925 16256-16264 VB denotes detected
T5926 16265-16267 IN denotes by
T5927 16268-16272 NN denotes flow
T5928 16273-16282 NN denotes cytometry
T5929 16283-16284 -LRB- denotes (
T5930 16284-16290 NN denotes Figure
T5931 16291-16293 NN denotes 3C
T5932 16293-16294 -RRB- denotes )
T5933 16296-16309 RB denotes Interestingly
T5934 16309-16310 -COMMA- denotes ,
T5935 16311-16315 NN denotes LMP1
T5936 16316-16324 NN denotes lymphoma
T5937 16325-16330 NN denotes cells
T5938 16331-16334 VB denotes had
T5939 16335-16348 RB denotes significantly
T5940 16349-16355 JJ denotes higher
T5941 16356-16362 NN denotes levels
T5942 16363-16365 IN denotes of
T5943 16366-16379 NN denotes proliferation
T5944 16380-16382 IN denotes in
T5945 16383-16393 NN denotes comparison
T5946 16394-16396 TO denotes to
T5947 16397-16400 DT denotes the
T5948 16401-16412 JJ denotes spontaneous
T5949 16413-16421 NN denotes lymphoma
T5950 16422-16426 WDT denotes that
T5951 16427-16436 VB denotes developed
T5952 16437-16439 IN denotes in
T5953 16440-16442 DT denotes an
T5954 16443-16456 JJ denotes LMP1-negative
T5955 16457-16467 NN denotes littermate
T5956 16468-16469 -LRB- denotes (
T5957 16469-16471 CD denotes 25
T5958 16471-16472 NN denotes %
T5959 16473-16479 IN denotes versus
T5960 16480-16481 CD denotes 4
T5961 16481-16482 NN denotes %
T5962 16482-16483 -RRB- denotes )
T5963 16485-16489 DT denotes This
T5964 16490-16496 JJ denotes higher
T5965 16497-16502 NN denotes level
T5966 16503-16505 IN denotes of
T5967 16506-16519 NN denotes proliferation
T5968 16520-16523 VB denotes was
T5969 16524-16532 VB denotes observed
T5970 16533-16535 IN denotes in
T5971 16536-16545 NN denotes lymphomas
T5972 16546-16550 WDT denotes that
T5973 16551-16558 VB denotes express
T5974 16559-16563 CC denotes both
T5975 16564-16568 JJ denotes high
T5976 16569-16570 -LRB- denotes (
T5977 16570-16575 JJ denotes Table
T5978 16576-16577 CD denotes 1
T5979 16577-16578 -COMMA- denotes ,
T5980 16579-16586 NN denotes LMP1-L2
T5981 16587-16590 CC denotes and
T5982 16591-16598 NN denotes LMP1-L3
T5983 16598-16599 -RRB- denotes )
T5984 16600-16603 CC denotes and
T5985 16604-16607 JJ denotes low
T5986 16608-16609 -LRB- denotes (
T5987 16609-16614 JJ denotes Table
T5988 16615-16616 CD denotes 1
T5989 16616-16617 -COMMA- denotes ,
T5990 16618-16625 NN denotes LMP1-L5
T5991 16625-16626 -RRB- denotes )
T5992 16627-16633 NN denotes levels
T5993 16634-16636 IN denotes of
T5994 16637-16641 NN denotes LMP1
T5995 16641-16642 -COMMA- denotes ,
T5996 16643-16653 VB denotes suggesting
T5997 16654-16658 IN denotes that
T5998 16659-16663 RB denotes even
T5999 16664-16669 JJ denotes small
T6000 16670-16677 NN denotes amounts
T6001 16678-16680 IN denotes of
T6002 16681-16685 NN denotes LMP1
T6003 16686-16688 VB denotes is
T6004 16689-16699 JJ denotes sufficient
T6005 16700-16702 TO denotes to
T6006 16703-16709 VB denotes induce
T6007 16710-16718 JJ denotes dramatic
T6008 16719-16726 NN denotes effects
T6009 16727-16729 IN denotes in
T6010 16730-16743 NN denotes proliferation
T6011 16745-16748 DT denotes The
T6012 16749-16754 NN denotes level
T6013 16755-16757 IN denotes of
T6014 16758-16771 NN denotes proliferation
T6015 16772-16775 VB denotes was
T6016 16776-16779 RB denotes not
T6017 16780-16788 VB denotes enhanced
T6018 16789-16793 IN denotes upon
T6019 16794-16797 NN denotes IL4
T6020 16798-16806 NN denotes addition
T6021 16806-16807 -COMMA- denotes ,
T6022 16808-16818 VB denotes confirming
T6023 16819-16822 DT denotes the
T6024 16823-16826 NN denotes IL4
T6025 16827-16839 NN denotes independence
T6026 16840-16848 VB denotes observed
T6027 16849-16851 IN denotes in
T6028 16852-16855 DT denotes the
T6029 16856-16865 NN denotes viability
T6030 16866-16873 NN denotes studies
T6031 16874-16875 -LRB- denotes (
T6032 16875-16881 NN denotes Figure
T6033 16882-16884 NN denotes 3C
T6034 16884-16885 -COLON- denotes ;
T6035 16886-16892 NN denotes Table1
T6036 16892-16893 -RRB- denotes )
T6408 8678-8687 NN denotes wild-type
T6409 9617-9620 CC denotes and
T6410 9621-9625 NN denotes LMP1
T6411 9626-9636 NNP denotes transgenic
T6412 9637-9645 NNP denotes lymphoma
T6413 17017-17022 NNP denotes Cells
T6414 17023-17025 NNP denotes Do
T6415 17026-17029 RB denotes Not
T6416 17030-17037 VB denotes Require
T6417 17038-17041 NN denotes IL4
T6418 17042-17045 CC denotes and
T6419 17046-17051 NN denotes Stat6
T6420 17052-17061 NN denotes Signaling
T6421 17062-17064 TO denotes To
T6422 17065-17076 VB denotes investigate
T6423 17077-17084 IN denotes whether
T6424 17085-17088 NN denotes IL4
T6425 17089-17101 NN denotes independence
T6426 17102-17105 VB denotes was
T6427 17106-17109 JJ denotes due
T6428 17110-17112 TO denotes to
T6429 17113-17123 JJ denotes endogenous
T6430 17124-17127 NN denotes IL4
T6431 17128-17138 NN denotes expression
T6432 17138-17139 -COMMA- denotes ,
T6433 17140-17143 NN denotes IL4
T6434 17144-17157 NN denotes transcription
T6435 17158-17161 VB denotes was
T6436 17162-17170 VB denotes assessed
T6437 17171-17173 IN denotes by
T6438 17174-17176 DT denotes an
T6439 17177-17182 NN denotes Rnase
T6440 17183-17193 NN denotes protection
T6441 17194-17199 NN denotes assay
T6442 17200-17201 -LRB- denotes (
T6443 17201-17204 NN denotes RPA
T6444 17204-17205 -RRB- denotes )
T6445 17207-17210 NN denotes IL4
T6446 17211-17224 NN denotes transcription
T6447 17225-17228 VB denotes was
T6448 17229-17239 JJ denotes detectable
T6449 17240-17244 IN denotes with
T6450 17245-17252 NN denotes control
T6451 17253-17256 NN denotes RNA
T6452 17257-17260 CC denotes and
T6453 17261-17268 RB denotes faintly
T6454 17269-17271 IN denotes in
T6455 17272-17275 DT denotes the
T6456 17276-17281 NN denotes mouse
T6457 17282-17290 NN denotes lymphoma
T6458 17291-17295 NN denotes cell
T6459 17296-17300 NN denotes line
T6460 17301-17305 NN denotes K46μ
T6461 17306-17307 -LRB- denotes (
T6462 17307-17313 NN denotes Figure
T6463 17314-17316 NN denotes 4A
T6464 17316-17317 -RRB- denotes )
T6465 17319-17326 RB denotes However
T6466 17326-17327 -COMMA- denotes ,
T6467 17328-17331 NN denotes IL4
T6468 17332-17345 NN denotes transcription
T6469 17346-17349 VB denotes was
T6470 17350-17353 RB denotes not
T6471 17354-17364 JJ denotes detectable
T6472 17365-17367 IN denotes in
T6473 17368-17373 JJ denotes CD19+
T6474 17374-17387 JJ denotes MACS-purified
T6475 17388-17389 NN denotes B
T6476 17390-17395 NN denotes cells
T6477 17396-17400 IN denotes from
T6478 17401-17410 JJ denotes wild-type
T6479 17411-17422 NN denotes lymphocytes
T6480 17423-17424 -LRB- denotes (
T6481 17424-17435 JJ denotes unpublished
T6482 17436-17440 NN denotes data
T6483 17440-17441 -RRB- denotes )
T6484 17441-17442 -COMMA- denotes ,
T6485 17443-17447 NN denotes LMP1
T6486 17448-17458 JJ denotes transgenic
T6487 17459-17470 NN denotes lymphocytes
T6488 17470-17471 -COMMA- denotes ,
T6489 17472-17474 CC denotes or
T6490 17475-17483 NN denotes lymphoma
T6491 17484-17489 NN denotes cells
T6492 17489-17490 -COMMA- denotes ,
T6493 17491-17499 IN denotes although
T6494 17500-17503 DT denotes the
T6495 17504-17509 NN denotes GAPDH
T6496 17510-17513 CC denotes and
T6497 17514-17517 NN denotes L32
T6498 17518-17526 NN denotes controls
T6499 17527-17531 VB denotes were
T6500 17532-17543 RB denotes effectively
T6501 17544-17553 VB denotes protected
T6502 17554-17555 -LRB- denotes (
T6503 17555-17561 NN denotes Figure
T6504 17562-17564 NN denotes 4A
T6505 17564-17565 -RRB- denotes )
T6506 17567-17576 VB denotes Activated
T6507 17577-17582 NN denotes Stat6
T6508 17583-17584 -LRB- denotes (
T6509 17584-17590 NN denotes pStat6
T6510 17590-17591 -RRB- denotes )
T6511 17591-17592 -COMMA- denotes ,
T6512 17593-17594 DT denotes a
T6513 17595-17601 NN denotes target
T6514 17602-17604 IN denotes of
T6515 17605-17608 DT denotes the
T6516 17609-17612 NN denotes IL4
T6517 17613-17621 NN denotes receptor
T6518 17622-17629 NN denotes pathway
T6519 17629-17630 -COMMA- denotes ,
T6520 17631-17634 VB denotes was
T6521 17635-17643 VB denotes detected
T6522 17644-17646 IN denotes in
T6523 17647-17650 DT denotes the
T6524 17651-17660 JJ denotes wild-type
T6525 17661-17664 CC denotes and
T6526 17665-17669 NN denotes LMP1
T6527 17670-17680 JJ denotes transgenic
T6528 17681-17692 NN denotes lymphocytes
T6529 17693-17694 -LRB- denotes (
T6530 17694-17700 NN denotes Figure
T6531 17701-17703 NN denotes 4B
T6532 17703-17704 -RRB- denotes )
T6533 17706-17708 IN denotes In
T6534 17709-17717 NN denotes contrast
T6535 17717-17718 -COMMA- denotes ,
T6536 17719-17725 NN denotes pStat6
T6537 17726-17729 VB denotes was
T6538 17730-17736 RB denotes barely
T6539 17737-17745 VB denotes detected
T6540 17746-17748 IN denotes in
T6541 17749-17755 CC denotes either
T6542 17756-17759 DT denotes the
T6543 17760-17769 JJ denotes wild-type
T6544 17770-17772 CC denotes or
T6545 17773-17777 NN denotes LMP1
T6546 17778-17788 JJ denotes transgenic
T6547 17789-17797 NN denotes lymphoma
T6548 17798-17803 NN denotes cells
T6549 17805-17812 RB denotes However
T6550 17812-17813 -COMMA- denotes ,
T6551 17814-17817 DT denotes the
T6552 17818-17825 NN denotes pathway
T6553 17826-17829 VB denotes was
T6554 17830-17833 RB denotes not
T6555 17834-17842 VB denotes disabled
T6556 17842-17843 -COMMA- denotes ,
T6557 17844-17846 IN denotes as
T6558 17847-17856 NN denotes treatment
T6559 17857-17859 IN denotes of
T6560 17860-17863 DT denotes the
T6561 17864-17872 NN denotes lymphoma
T6562 17873-17878 NN denotes cells
T6563 17879-17883 IN denotes with
T6564 17884-17887 NN denotes IL4
T6565 17888-17895 VB denotes induced
T6566 17896-17901 NN denotes Stat6
T6567 17902-17917 NN denotes phosphorylation
T6568 17918-17919 -LRB- denotes (
T6569 17919-17925 NN denotes Figure
T6570 17926-17928 NN denotes 4C
T6571 17928-17929 -RRB- denotes )
T6572 18976-18984 IN denotes Although
T6573 18985-18994 JJ denotes wild-type
T6574 18995-19006 NN denotes lymphocytes
T6575 19007-19010 MD denotes can
T6576 19010-19013 RB denotes not
T6577 19014-19016 VB denotes be
T6578 19017-19027 VB denotes maintained
T6579 19028-19030 IN denotes in
T6580 19031-19038 NN denotes culture
T6581 19039-19043 IN denotes with
T6582 19044-19047 NN denotes IL4
T6583 19048-19063 NN denotes supplementation
T6584 19064-19069 RB denotes alone
T6585 19070-19071 -LRB- denotes (
T6586 19071-19077 NN denotes Figure
T6587 19078-19080 NN denotes 3A
T6588 19080-19081 -RRB- denotes )
T6589 19081-19082 -COMMA- denotes ,
T6590 19083-19089 JJ denotes slight
T6591 19090-19101 NN denotes enhancement
T6592 19102-19104 IN denotes in
T6593 19105-19108 NN denotes MTS
T6594 19109-19117 NN denotes activity
T6595 19118-19123 MD denotes could
T6596 19124-19126 VB denotes be
T6597 19127-19135 VB denotes detected
T6598 19136-19138 IN denotes if
T6599 19139-19142 DT denotes the
T6600 19143-19148 NN denotes cells
T6601 19149-19153 VB denotes were
T6602 19154-19162 VB denotes analyzed
T6603 19163-19165 IN denotes at
T6604 19166-19168 DT denotes an
T6605 19169-19176 JJ denotes earlier
T6606 19177-19181 NN denotes time
T6607 19182-19187 NN denotes point
T6608 19187-19188 -COMMA- denotes ,
T6609 19189-19191 IN denotes at
T6610 19192-19193 CD denotes 1
T6611 19194-19195 NN denotes d
T6612 19196-19197 -LRB- denotes (
T6613 19197-19203 NN denotes Figure
T6614 19204-19206 NN denotes 4D
T6615 19206-19207 -RRB- denotes )
T6616 19208-19214 IN denotes versus
T6617 19215-19216 CD denotes 3
T6618 19217-19218 NN denotes d
T6619 19219-19220 -LRB- denotes (
T6620 19220-19226 NN denotes Figure
T6621 19227-19229 NN denotes 3A
T6622 19229-19230 -RRB- denotes )
T6623 19231-19243 JJ denotes post-harvest
T6624 19245-19248 DT denotes The
T6625 19249-19260 NN denotes enhancement
T6626 19261-19263 IN denotes of
T6627 19264-19267 NN denotes MTS
T6628 19268-19276 NN denotes activity
T6629 19277-19284 VB denotes induced
T6630 19285-19287 IN denotes by
T6631 19288-19291 NN denotes IL4
T6632 19292-19294 IN denotes in
T6633 19295-19304 JJ denotes wild-type
T6634 19305-19316 NN denotes lymphocytes
T6635 19317-19322 MD denotes could
T6636 19323-19325 VB denotes be
T6637 19326-19337 VB denotes neutralized
T6638 19338-19340 IN denotes by
T6639 19341-19344 DT denotes the
T6640 19345-19353 NN denotes addition
T6641 19354-19356 IN denotes of
T6642 19357-19360 NN denotes IL4
T6643 19361-19369 NN denotes antibody
T6644 19370-19371 -LRB- denotes (
T6645 19371-19377 NN denotes Figure
T6646 19378-19380 NN denotes 4D
T6647 19380-19381 -RRB- denotes )
T6648 19383-19390 RB denotes However
T6649 19390-19391 -COMMA- denotes ,
T6650 19392-19404 VB denotes neutralizing
T6651 19405-19415 NN denotes antibodies
T6652 19416-19418 TO denotes to
T6653 19419-19422 NN denotes IL4
T6654 19423-19426 VB denotes did
T6655 19427-19430 RB denotes not
T6656 19431-19437 VB denotes affect
T6657 19438-19441 DT denotes the
T6658 19442-19445 NN denotes MTS
T6659 19446-19454 NN denotes activity
T6660 19455-19457 IN denotes of
T6661 19458-19462 NN denotes LMP1
T6662 19463-19473 JJ denotes transgenic
T6663 19474-19482 NN denotes lymphoma
T6664 19483-19488 NN denotes cells
T6665 19489-19490 -LRB- denotes (
T6666 19490-19496 NN denotes Figure
T6667 19497-19499 NN denotes 4E
T6668 19499-19500 -RRB- denotes )
T6669 19502-19504 IN denotes In
T6670 19505-19512 NN denotes summary
T6671 19512-19513 -COMMA- denotes ,
T6672 19514-19517 DT denotes the
T6673 19518-19527 JJ denotes wild-type
T6674 19528-19531 CC denotes and
T6675 19532-19536 NN denotes LMP1
T6676 19537-19547 JJ denotes transgenic
T6677 19548-19556 NN denotes lymphoma
T6678 19557-19562 NN denotes cells
T6679 19563-19567 VB denotes grew
T6680 19568-19581 RB denotes independently
T6681 19582-19584 IN denotes of
T6682 19585-19588 NN denotes IL4
T6683 19589-19598 NN denotes treatment
T6684 19599-19602 CC denotes and
T6685 19603-19606 VB denotes did
T6686 19607-19610 RB denotes not
T6687 19611-19618 VB denotes require
T6688 19619-19624 NN denotes Stat6
T6689 19625-19634 NN denotes signaling
T7580 19637-19641 NN denotes LMP1
T7581 19642-19653 VB denotes Upregulates
T7582 19654-19658 NN denotes IL10
T7583 19659-19662 CC denotes and
T7584 19663-19677 RB denotes Constitutively
T7585 19678-19687 VB denotes Activates
T7586 19688-19693 NN denotes Stat3
T7587 19694-19696 TO denotes To
T7588 19697-19705 VB denotes identify
T7589 19706-19715 NN denotes cytokines
T7590 19716-19720 WDT denotes that
T7591 19721-19724 MD denotes may
T7592 19725-19735 VB denotes contribute
T7593 19736-19738 TO denotes to
T7594 19739-19742 DT denotes the
T7595 19743-19752 VB denotes increased
T7596 19753-19761 NN denotes survival
T7597 19762-19765 CC denotes and
T7598 19766-19772 NN denotes growth
T7599 19773-19775 IN denotes of
T7600 19776-19785 NN denotes lymphomas
T7601 19785-19786 -COMMA- denotes ,
T7602 19787-19790 DT denotes the
T7603 19791-19801 NN denotes expression
T7604 19802-19808 NN denotes levels
T7605 19809-19811 IN denotes of
T7606 19812-19813 DT denotes a
T7607 19814-19819 NN denotes panel
T7608 19820-19822 IN denotes of
T7609 19823-19832 NN denotes cytokines
T7610 19833-19837 VB denotes were
T7611 19838-19846 VB denotes screened
T7612 19847-19849 IN denotes on
T7613 19850-19855 JJ denotes CD19+
T7614 19856-19869 JJ denotes MACS-purified
T7615 19870-19871 NN denotes B
T7616 19872-19877 NN denotes cells
T7617 19877-19878 -COMMA- denotes ,
T7618 19879-19884 VB denotes using
T7619 19885-19887 DT denotes an
T7620 19888-19891 NN denotes RPA
T7621 19892-19897 NN denotes probe
T7622 19898-19901 VB denotes set
T7623 19902-19905 IN denotes for
T7624 19906-19909 NN denotes IL4
T7625 19909-19910 -COMMA- denotes ,
T7626 19911-19914 NN denotes IL5
T7627 19914-19915 -COMMA- denotes ,
T7628 19916-19920 NN denotes IL10
T7629 19920-19921 -COMMA- denotes ,
T7630 19922-19926 NN denotes IL13
T7631 19926-19927 -COMMA- denotes ,
T7632 19928-19932 NN denotes IL15
T7633 19932-19933 -COMMA- denotes ,
T7634 19934-19937 NN denotes IL9
T7635 19937-19938 -COMMA- denotes ,
T7636 19939-19942 NN denotes IL2
T7637 19942-19943 -COMMA- denotes ,
T7638 19944-19947 NN denotes IL6
T7639 19947-19948 -COMMA- denotes ,
T7640 19949-19952 CC denotes and
T7641 19953-19957 NN denotes IFNγ
T7642 19959-19969 NN denotes Expression
T7643 19970-19976 NN denotes levels
T7644 19977-19981 VB denotes were
T7645 19982-19992 VB denotes quantified
T7646 19993-19997 IN denotes with
T7647 19998-19999 DT denotes a
T7648 20000-20014 NN denotes phosphorimager
T7649 20015-20018 CC denotes and
T7650 20019-20029 VB denotes normalized
T7651 20030-20032 TO denotes to
T7652 20033-20036 DT denotes the
T7653 20037-20046 JJ denotes ribosomal
T7654 20047-20059 NN denotes housekeeping
T7655 20060-20064 NN denotes gene
T7656 20065-20068 NN denotes L32
T7657 20070-20074 NN denotes None
T7658 20075-20077 IN denotes of
T7659 20078-20081 DT denotes the
T7660 20082-20088 VB denotes tested
T7661 20089-20098 NN denotes cytokines
T7662 20099-20103 VB denotes were
T7663 20104-20112 VB denotes detected
T7664 20113-20115 IN denotes in
T7665 20116-20125 JJ denotes wild-type
T7666 20126-20137 NN denotes lymphocytes
T7667 20137-20138 -COMMA- denotes ,
T7668 20139-20148 RB denotes therefore
T7669 20149-20157 NN denotes cytokine
T7670 20157-20158 -COLON- denotes :
T7671 20158-20161 NN denotes L32
T7672 20162-20168 NN denotes ratios
T7673 20169-20173 VB denotes were
T7674 20174-20177 VB denotes set
T7675 20178-20180 TO denotes to
T7676 20181-20182 CD denotes 1
T7677 20183-20185 IN denotes in
T7678 20186-20189 DT denotes the
T7679 20190-20195 NN denotes mouse
T7680 20196-20197 NN denotes B
T7681 20198-20202 NN denotes cell
T7682 20203-20211 NN denotes lymphoma
T7683 20212-20216 NN denotes line
T7684 20217-20220 CD denotes 967
T7685 20222-20235 NN denotes Transcription
T7686 20236-20238 IN denotes of
T7687 20239-20243 NN denotes IL10
T7688 20243-20244 -COMMA- denotes ,
T7689 20245-20249 NN denotes IL15
T7690 20249-20250 -COMMA- denotes ,
T7691 20251-20254 CC denotes and
T7692 20255-20259 NN denotes IFNγ
T7693 20260-20264 VB denotes were
T7694 20265-20277 RB denotes reproducibly
T7695 20278-20286 VB denotes detected
T7696 20287-20289 IN denotes in
T7697 20290-20294 NN denotes LMP1
T7698 20295-20305 JJ denotes transgenic
T7699 20306-20317 NN denotes lymphocytes
T7700 20318-20321 CC denotes and
T7701 20322-20330 NN denotes lymphoma
T7702 20331-20336 NN denotes cells
T7703 20337-20340 CC denotes and
T7704 20341-20344 VB denotes was
T7705 20345-20351 JJ denotes higher
T7706 20352-20356 IN denotes than
T7707 20357-20359 IN denotes in
T7708 20360-20363 DT denotes the
T7709 20364-20365 NN denotes B
T7710 20366-20370 NN denotes cell
T7711 20371-20379 NN denotes lymphoma
T7712 20380-20384 NN denotes cell
T7713 20385-20390 NN denotes lines
T7714 20391-20394 CD denotes 967
T7715 20395-20398 CC denotes and
T7716 20399-20403 NN denotes K46μ
T7717 20404-20405 -LRB- denotes (
T7718 20405-20411 NN denotes Figure
T7719 20412-20414 NN denotes 5A
T7720 20414-20415 -RRB- denotes )
T7721 20417-20422 EX denotes There
T7722 20423-20426 VB denotes was
T7723 20427-20429 DT denotes no
T7724 20430-20441 JJ denotes significant
T7725 20442-20452 NN denotes difference
T7726 20453-20455 IN denotes in
T7727 20456-20459 DT denotes the
T7728 20460-20470 NN denotes expression
T7729 20471-20473 IN denotes of
T7730 20474-20478 NN denotes IL15
T7731 20479-20482 CC denotes and
T7732 20483-20487 NN denotes IFNγ
T7733 20488-20495 IN denotes between
T7734 20496-20500 NN denotes LMP1
T7735 20501-20511 JJ denotes transgenic
T7736 20512-20523 NN denotes lymphocytes
T7737 20524-20527 CC denotes and
T7738 20528-20536 NN denotes lymphoma
T7739 20537-20542 NN denotes cells
T7740 20542-20543 -COMMA- denotes ,
T7741 20544-20554 VB denotes suggesting
T7742 20555-20559 IN denotes that
T7743 20560-20572 NN denotes upregulation
T7744 20573-20575 IN denotes of
T7745 20576-20580 NN denotes IL15
T7746 20581-20584 CC denotes and
T7747 20585-20589 NN denotes IFNγ
T7748 20590-20592 VB denotes is
T7749 20593-20600 VB denotes induced
T7750 20601-20603 IN denotes by
T7751 20604-20608 NN denotes LMP1
T7752 20609-20619 NN denotes expression
T7753 20620-20622 IN denotes in
T7754 20623-20630 JJ denotes healthy
T7755 20631-20642 NN denotes lymphocytes
T7756 20643-20646 CC denotes but
T7757 20647-20649 VB denotes is
T7758 20650-20653 RB denotes not
T7759 20654-20655 DT denotes a
T7760 20656-20662 JJ denotes unique
T7761 20663-20671 NN denotes property
T7762 20672-20674 IN denotes of
T7763 20675-20684 JJ denotes malignant
T7764 20685-20696 NN denotes lymphocytes
T7765 20698-20708 RB denotes Strikingly
T7766 20708-20709 -COMMA- denotes ,
T7767 20710-20714 NN denotes IL10
T7768 20714-20715 -COMMA- denotes ,
T7769 20716-20717 DT denotes a
T7770 20718-20719 NN denotes B
T7771 20720-20730 NN denotes lymphocyte
T7772 20731-20742 JJ denotes stimulatory
T7773 20743-20751 NN denotes cytokine
T7774 20751-20752 -COMMA- denotes ,
T7775 20753-20756 VB denotes was
T7776 20757-20766 VB denotes increased
T7777 20767-20771 CD denotes 1.5-
T7778 20772-20774 TO denotes to
T7779 20775-20781 RB denotes 5-fold
T7780 20782-20784 IN denotes in
T7781 20785-20788 DT denotes the
T7782 20789-20798 JJ denotes wild-type
T7783 20799-20802 CC denotes and
T7784 20803-20807 NN denotes LMP1
T7785 20808-20818 JJ denotes transgenic
T7786 20819-20827 NN denotes lymphoma
T7787 20828-20833 NN denotes cells
T7788 20834-20842 VB denotes compared
T7789 20843-20845 TO denotes to
T7790 20846-20850 NN denotes LMP1
T7791 20851-20861 JJ denotes transgenic
T7792 20862-20873 NN denotes lymphocytes
T7793 20874-20875 -LRB- denotes (
T7794 20875-20881 NN denotes Figure
T7795 20882-20884 NN denotes 5A
T7796 20884-20885 -RRB- denotes )
T7797 20887-20897 NN denotes Production
T7798 20898-20900 IN denotes of
T7799 20901-20905 NN denotes IL15
T7800 20906-20909 CC denotes and
T7801 20910-20914 NN denotes IFNγ
T7802 20915-20918 VB denotes has
T7803 20919-20923 VB denotes been
T7804 20924-20934 VB denotes associated
T7805 20935-20939 IN denotes with
T7806 20940-20949 NN denotes induction
T7807 20950-20952 IN denotes of
T7808 20953-20962 JJ denotes cytotoxic
T7809 20963-20971 NN denotes effector
T7810 20972-20981 NN denotes responses
T7811 20982-20984 IN denotes in
T7812 20985-20990 NN denotes cells
T7813 20991-20999 RB denotes latently
T7814 21000-21008 VB denotes infected
T7815 21009-21013 IN denotes with
T7816 21014-21017 NN denotes EBV
T7817 21018-21019 -LRB- denotes [
T7818 21019-21024 CD denotes 33,34
T7819 21024-21025 -RRB- denotes ]
T7820 21027-21034 RB denotes However
T7821 21034-21035 -COMMA- denotes ,
T7822 21036-21050 NN denotes transformation
T7823 21051-21054 CC denotes and
T7824 21055-21061 NN denotes growth
T7825 21062-21072 NN denotes properties
T7826 21073-21080 VB denotes induced
T7827 21081-21083 IN denotes by
T7828 21084-21087 NN denotes EBV
T7829 21088-21091 VB denotes are
T7830 21092-21102 VB denotes associated
T7831 21103-21107 IN denotes with
T7832 21108-21111 DT denotes the
T7833 21112-21124 NN denotes upregulation
T7834 21125-21127 IN denotes of
T7835 21128-21132 NN denotes IL10
T7836 21133-21134 -LRB- denotes [
T7837 21134-21139 CD denotes 35–38
T7838 21139-21140 -RRB- denotes ]
T7839 21140-21141 -COLON- denotes ;
T7840 21142-21147 RB denotes hence
T7841 21147-21148 -COMMA- denotes ,
T7842 21149-21152 DT denotes the
T7843 21153-21160 NN denotes effects
T7844 21161-21163 IN denotes of
T7845 21164-21168 NN denotes IL10
T7846 21169-21181 NN denotes upregulation
T7847 21182-21184 IN denotes on
T7848 21185-21188 DT denotes the
T7849 21189-21195 NN denotes growth
T7850 21196-21206 NN denotes properties
T7851 21207-21209 IN denotes of
T7852 21210-21213 DT denotes the
T7853 21214-21222 NN denotes lymphoma
T7854 21223-21228 NN denotes cells
T7855 21229-21233 VB denotes were
T7856 21234-21241 RB denotes further
T7857 21242-21250 VB denotes examined
T7858 21252-21262 NN denotes Immunoblot
T7859 21263-21271 NN denotes analysis
T7860 21272-21281 VB denotes indicated
T7861 21282-21286 IN denotes that
T7862 21287-21291 NN denotes LMP1
T7863 21292-21302 JJ denotes transgenic
T7864 21303-21314 NN denotes lymphocytes
T7865 21315-21318 CC denotes and
T7866 21319-21328 JJ denotes wild-type
T7867 21329-21332 CC denotes and
T7868 21333-21337 NN denotes LMP1
T7869 21338-21348 JJ denotes transgenic
T7870 21349-21357 NN denotes lymphoma
T7871 21358-21363 NN denotes cells
T7872 21364-21367 VB denotes had
T7873 21368-21381 VB denotes corresponding
T7874 21382-21391 VB denotes increased
T7875 21392-21398 NN denotes levels
T7876 21399-21401 IN denotes of
T7877 21402-21416 VB denotes phosphorylated
T7878 21417-21418 NN denotes α
T7879 21419-21422 CC denotes and
T7880 21423-21424 VB denotes β
T7881 21425-21433 NN denotes isoforms
T7882 21434-21436 IN denotes of
T7883 21437-21446 VB denotes activated
T7884 21447-21452 NN denotes Stat3
T7885 21452-21453 -COMMA- denotes ,
T7886 21454-21455 DT denotes a
T7887 21456-21462 NN denotes target
T7888 21463-21465 IN denotes of
T7889 21466-21469 DT denotes the
T7890 21470-21474 NN denotes IL10
T7891 21475-21483 NN denotes receptor
T7892 21484-21485 -LRB- denotes (
T7893 21485-21491 NN denotes Figure
T7894 21492-21494 NN denotes 5B
T7895 21494-21495 -RRB- denotes )
T7896 21497-21504 RB denotes However
T7897 21504-21505 -COMMA- denotes ,
T7898 21506-21510 WRB denotes when
T7899 21511-21520 VB denotes comparing
T7900 21521-21524 DT denotes the
T7901 21525-21529 JJ denotes same
T7902 21530-21539 NN denotes lymphomas
T7903 21539-21540 -COMMA- denotes ,
T7904 21541-21546 EX denotes there
T7905 21547-21550 VB denotes was
T7906 21551-21553 DT denotes no
T7907 21554-21565 NN denotes correlation
T7908 21566-21573 IN denotes between
T7909 21574-21577 DT denotes the
T7910 21578-21584 NN denotes levels
T7911 21585-21587 IN denotes of
T7912 21588-21592 NN denotes IL10
T7913 21593-21602 NN denotes induction
T7914 21603-21606 CC denotes and
T7915 21607-21610 DT denotes the
T7916 21611-21617 NN denotes levels
T7917 21618-21620 IN denotes of
T7918 21621-21626 NN denotes Stat3
T7919 21627-21637 NN denotes activation
T7920 21639-21643 DT denotes This
T7921 21644-21652 VB denotes suggests
T7922 21653-21657 IN denotes that
T7923 21658-21661 DT denotes the
T7924 21662-21672 NN denotes activation
T7925 21673-21675 IN denotes of
T7926 21676-21681 NN denotes Stat3
T7927 21682-21684 VB denotes is
T7928 21685-21688 RB denotes not
T7929 21689-21695 RB denotes solely
T7930 21696-21703 VB denotes induced
T7931 21704-21706 IN denotes by
T7932 21707-21711 NN denotes IL10
T7933 21712-21714 CC denotes or
T7934 21715-21719 IN denotes that
T7935 21720-21725 NN denotes Stat3
T7936 21726-21736 NN denotes activation
T7937 21737-21740 MD denotes may
T7938 21741-21743 VB denotes be
T7939 21744-21756 JJ denotes constitutive
T7940 21758-21770 RB denotes Additionally
T7941 21770-21771 -COMMA- denotes ,
T7942 21772-21777 EX denotes there
T7943 21778-21781 VB denotes was
T7944 21782-21784 DT denotes no
T7945 21785-21796 NN denotes correlation
T7946 21797-21804 IN denotes between
T7947 21805-21808 DT denotes the
T7948 21809-21815 NN denotes levels
T7949 21816-21818 IN denotes of
T7950 21819-21823 NN denotes LMP1
T7951 21824-21834 NN denotes expression
T7952 21835-21838 CC denotes and
T7953 21839-21842 DT denotes the
T7954 21843-21849 NN denotes levels
T7955 21850-21852 IN denotes of
T7956 21853-21857 NN denotes IL10
T7957 21858-21867 NN denotes induction
T7958 21868-21869 -LRB- denotes (
T7959 21869-21876 NN denotes Figures
T7960 21877-21879 NN denotes 1A
T7961 21880-21883 CC denotes and
T7962 21884-21886 NN denotes 5A
T7963 21886-21887 -RRB- denotes )
T7964 21889-21893 DT denotes This
T7965 21894-21903 VB denotes indicates
T7966 21904-21908 IN denotes that
T7967 21909-21912 DT denotes the
T7968 21913-21922 NN denotes induction
T7969 21923-21925 IN denotes of
T7970 21926-21930 NN denotes IL10
T7971 21931-21933 VB denotes is
T7972 21934-21935 DT denotes a
T7973 21936-21943 JJ denotes general
T7974 21944-21952 NN denotes property
T7975 21953-21963 VB denotes associated
T7976 21964-21968 IN denotes with
T7977 21969-21977 VB denotes enhanced
T7978 21978-21986 NN denotes survival
T7979 21987-21990 CC denotes and
T7980 21991-21994 MD denotes may
T7981 21995-21999 RB denotes only
T7982 22000-22002 VB denotes be
T7983 22003-22013 RB denotes indirectly
T7984 22014-22022 VB denotes affected
T7985 22023-22025 IN denotes by
T7986 22026-22030 NN denotes LMP1
T7987 22032-22044 VB denotes Neutralizing
T7988 22045-22055 NN denotes antibodies
T7989 22056-22058 TO denotes to
T7990 22059-22063 NN denotes IL10
T7991 22064-22067 VB denotes did
T7992 22068-22071 RB denotes not
T7993 22072-22078 VB denotes affect
T7994 22079-22082 DT denotes the
T7995 22083-22091 NN denotes survival
T7996 22092-22094 IN denotes of
T7997 22095-22103 NN denotes lymphoma
T7998 22104-22109 NN denotes cells
T7999 22110-22112 IN denotes as
T8000 22113-22123 VB denotes determined
T8001 22124-22126 IN denotes by
T8002 22127-22130 DT denotes the
T8003 22131-22134 NN denotes MTS
T8004 22135-22140 NN denotes assay
T8005 22141-22142 -LRB- denotes (
T8006 22142-22153 JJ denotes unpublished
T8007 22154-22158 NN denotes data
T8008 22158-22159 -RRB- denotes )
T8009 22159-22160 -COMMA- denotes ,
T8010 22161-22171 VB denotes suggesting
T8011 22172-22184 JJ denotes constitutive
T8012 22185-22195 NN denotes activation
T8013 22196-22198 IN denotes of
T8014 22199-22204 NN denotes Stat3
T8015 22206-22210 DT denotes This
T8016 22211-22214 VB denotes was
T8017 22215-22224 VB denotes confirmed
T8018 22225-22227 IN denotes by
T8019 22228-22238 NN denotes immunoblot
T8020 22239-22247 NN denotes analysis
T8021 22248-22252 JJ denotes such
T8022 22253-22257 IN denotes that
T8023 22258-22260 IN denotes in
T8024 22261-22264 DT denotes the
T8025 22265-22273 NN denotes presence
T8026 22274-22276 IN denotes of
T8027 22277-22286 JJ denotes anti-IL10
T8028 22287-22299 VB denotes neutralizing
T8029 22300-22310 NN denotes antibodies
T8030 22310-22311 -COMMA- denotes ,
T8031 22312-22318 NN denotes pStat3
T8032 22319-22325 NN denotes levels
T8033 22326-22334 VB denotes remained
T8034 22335-22344 VB denotes activated
T8035 22345-22347 IN denotes in
T8036 22348-22356 NN denotes lymphoma
T8037 22357-22362 NN denotes cells
T8038 22363-22371 VB denotes isolated
T8039 22372-22376 IN denotes from
T8040 22377-22386 JJ denotes wild-type
T8041 22387-22390 CC denotes and
T8042 22391-22395 NN denotes LMP1
T8043 22396-22406 JJ denotes transgenic
T8044 22407-22416 NN denotes lymphomas
T8045 22417-22418 -LRB- denotes (
T8046 22418-22424 NN denotes Figure
T8047 22425-22427 NN denotes 5C
T8048 22427-22428 -RRB- denotes )
T8049 22430-22439 JJ denotes Exogenous
T8050 22440-22448 NN denotes addition
T8051 22449-22451 IN denotes of
T8052 22452-22456 NN denotes IL10
T8053 22457-22465 VB denotes enhanced
T8054 22466-22472 NN denotes pStat3
T8055 22473-22483 NN denotes activation
T8056 22484-22489 IN denotes above
T8057 22490-22502 JJ denotes constitutive
T8058 22503-22509 NN denotes levels
T8059 22509-22510 -COMMA- denotes ,
T8060 22511-22521 VB denotes indicating
T8061 22522-22526 IN denotes that
T8062 22527-22535 NN denotes lymphoma
T8063 22536-22541 NN denotes cells
T8064 22542-22545 VB denotes are
T8065 22546-22556 JJ denotes responsive
T8066 22557-22559 TO denotes to
T8067 22560-22564 NN denotes IL10
T8068 22565-22574 NN denotes treatment
T8069 22575-22576 -LRB- denotes (
T8070 22576-22582 NN denotes Figure
T8071 22583-22585 NN denotes 5C
T8072 22585-22586 -RRB- denotes )
T8073 22588-22592 DT denotes This
T8074 22593-22598 VB denotes means
T8075 22599-22603 IN denotes that
T8076 22604-22612 IN denotes although
T8077 22613-22616 DT denotes the
T8078 22617-22625 NN denotes lymphoma
T8079 22626-22631 NN denotes cells
T8080 22632-22636 VB denotes have
T8081 22637-22649 JJ denotes constitutive
T8082 22650-22655 NN denotes Stat3
T8083 22656-22666 NN denotes activation
T8084 22666-22667 -COMMA- denotes ,
T8085 22668-22670 PRP denotes it
T8086 22671-22674 MD denotes may
T8087 22675-22677 VB denotes be
T8088 22678-22685 RB denotes further
T8089 22686-22694 VB denotes enhanced
T8090 22695-22697 IN denotes by
T8091 22698-22702 NN denotes IL10
T8092 22703-22712 NN denotes induction
T8093 22714-22717 DT denotes The
T8094 22718-22730 VB denotes neutralizing
T8095 22731-22737 NN denotes effect
T8096 22738-22740 IN denotes of
T8097 22741-22744 DT denotes the
T8098 22745-22754 JJ denotes anti-IL10
T8099 22755-22763 NN denotes antibody
T8100 22764-22767 VB denotes was
T8101 22768-22777 VB denotes confirmed
T8102 22778-22780 IN denotes by
T8103 22781-22795 NN denotes pre-incubation
T8104 22796-22798 IN denotes of
T8105 22799-22803 NN denotes IL10
T8106 22804-22808 IN denotes with
T8107 22809-22818 JJ denotes anti-IL10
T8108 22819-22827 NN denotes antibody
T8109 22828-22836 VB denotes compared
T8110 22837-22839 TO denotes to
T8111 22840-22841 DT denotes a
T8112 22842-22845 NN denotes rat
T8113 22846-22850 NN denotes IgG1
T8114 22851-22858 NN denotes isotype
T8115 22859-22866 NN denotes control
T8116 22867-22868 -LRB- denotes (
T8117 22868-22874 NN denotes Figure
T8118 22875-22877 NN denotes 5C
T8119 22877-22878 -RRB- denotes )
T8120 23916-23923 JJ denotes Nuclear
T8121 23924-23937 NN denotes translocation
T8122 23938-23940 IN denotes of
T8123 23941-23947 NN denotes pStat3
T8124 23948-23950 VB denotes is
T8125 23951-23952 DT denotes a
T8126 23953-23964 NN denotes consequence
T8127 23965-23967 IN denotes of
T8128 23968-23978 NN denotes activation
T8129 23978-23979 -COMMA- denotes ,
T8130 23980-23983 CC denotes and
T8131 23984-23991 JJ denotes nuclear
T8132 23992-23998 NN denotes pStat3
T8133 23999-24002 VB denotes was
T8134 24003-24006 RB denotes not
T8135 24007-24015 VB denotes detected
T8136 24016-24018 IN denotes by
T8137 24019-24039 NN denotes immunohistochemistry
T8138 24040-24048 NN denotes staining
T8139 24049-24051 IN denotes of
T8140 24052-24058 NN denotes spleen
T8141 24059-24067 NN denotes sections
T8142 24068-24072 IN denotes from
T8143 24073-24080 NN denotes control
T8144 24081-24085 NN denotes mice
T8145 24087-24094 RB denotes However
T8146 24094-24095 -COMMA- denotes ,
T8147 24096-24103 JJ denotes nuclear
T8148 24104-24110 NN denotes pStat3
T8149 24111-24114 VB denotes was
T8150 24115-24125 JJ denotes detectable
T8151 24126-24128 IN denotes in
T8152 24129-24133 NN denotes LMP1
T8153 24134-24144 JJ denotes transgenic
T8154 24145-24149 NN denotes mice
T8155 24150-24153 CC denotes and
T8156 24154-24163 JJ denotes wild-type
T8157 24164-24173 NN denotes lymphomas
T8158 24174-24177 CC denotes and
T8159 24178-24181 VB denotes was
T8160 24182-24190 VB denotes detected
T8161 24191-24195 RB denotes more
T8162 24196-24209 RB denotes homogeneously
T8163 24210-24212 IN denotes in
T8164 24213-24217 NN denotes LMP1
T8165 24218-24228 JJ denotes transgenic
T8166 24229-24238 NN denotes lymphomas
T8167 24239-24240 -LRB- denotes (
T8168 24240-24246 NN denotes Figure
T8169 24247-24249 NN denotes 5D
T8170 24249-24250 -RRB- denotes )
T8171 24252-24255 DT denotes The
T8172 24256-24268 JJ denotes constitutive
T8173 24269-24279 NN denotes activation
T8174 24280-24282 IN denotes of
T8175 24283-24289 NN denotes pStat3
T8176 24290-24293 CC denotes and
T8177 24294-24302 JJ denotes abundant
T8178 24303-24310 JJ denotes nuclear
T8179 24311-24316 NN denotes Stat3
T8180 24317-24325 VB denotes suggests
T8181 24326-24330 IN denotes that
T8182 24331-24336 NN denotes Stat3
T8183 24337-24346 NN denotes signaling
T8184 24347-24358 VB denotes contributes
T8185 24359-24361 TO denotes to
T8186 24362-24375 JJ denotes LMP1-mediated
T8187 24376-24384 NN denotes lymphoma
T8188 24385-24396 NN denotes development
T9824 24399-24403 NN denotes LMP1
T9825 24404-24413 VB denotes Activates
T9826 24414-24417 NN denotes Akt
T9827 24418-24427 NN denotes Signaling
T9828 24428-24431 CC denotes and
T9829 24432-24443 VB denotes Deregulates
T9830 24444-24447 DT denotes the
T9831 24448-24450 NNP denotes Rb
T9832 24451-24455 NNP denotes Cell
T9833 24456-24461 NNP denotes Cycle
T9834 24462-24469 NNP denotes Pathway
T9835 24470-24474 NN denotes LMP1
T9836 24475-24489 NN denotes transformation
T9837 24490-24492 IN denotes of
T9838 24493-24499 JJ denotes rodent
T9839 24500-24511 NN denotes fibroblasts
T9840 24512-24520 VB denotes requires
T9841 24521-24531 NN denotes activation
T9842 24532-24534 IN denotes of
T9843 24535-24539 NN denotes PI3K
T9844 24540-24543 CC denotes and
T9845 24544-24547 NN denotes Akt
T9846 24548-24549 -LRB- denotes [
T9847 24549-24550 CD denotes 5
T9848 24550-24551 -RRB- denotes ]
T9849 24553-24565 RB denotes Additionally
T9850 24565-24566 -COMMA- denotes ,
T9851 24567-24576 VB denotes activated
T9852 24577-24581 NN denotes pAkt
T9853 24582-24584 VB denotes is
T9854 24585-24595 RB denotes frequently
T9855 24596-24604 VB denotes detected
T9856 24605-24607 IN denotes in
T9857 24608-24611 NN denotes NPC
T9858 24612-24615 CC denotes and
T9859 24616-24619 DT denotes the
T9860 24620-24630 JJ denotes neoplastic
T9861 24631-24645 NN denotes Reed-Sternberg
T9862 24646-24651 NN denotes cells
T9863 24652-24654 IN denotes of
T9864 24655-24664 JJ denotes classical
T9865 24665-24667 NN denotes HD
T9866 24668-24669 -LRB- denotes [
T9867 24669-24674 CD denotes 39,40
T9868 24674-24675 -RRB- denotes ]
T9869 24677-24679 TO denotes To
T9870 24680-24689 VB denotes determine
T9871 24690-24692 IN denotes if
T9872 24693-24696 NN denotes Akt
T9873 24697-24706 NN denotes signaling
T9874 24707-24709 VB denotes is
T9875 24710-24719 VB denotes activated
T9876 24720-24722 IN denotes in
T9877 24723-24727 NN denotes LMP1
T9878 24728-24738 JJ denotes transgenic
T9879 24739-24743 NN denotes mice
T9880 24743-24744 -COMMA- denotes ,
T9881 24745-24749 NN denotes pAkt
T9882 24750-24753 CC denotes and
T9883 24754-24761 JJ denotes several
T9884 24762-24764 IN denotes of
T9885 24765-24768 PRP-DOLLAR- denotes its
T9886 24769-24776 NN denotes targets
T9887 24777-24781 VB denotes were
T9888 24782-24790 VB denotes assessed
T9889 24791-24793 IN denotes by
T9890 24794-24808 NN denotes immunoblotting
T9891 24809-24811 IN denotes of
T9892 24812-24819 JJ denotes splenic
T9893 24820-24825 JJ denotes CD19+
T9894 24826-24839 JJ denotes MACS-purified
T9895 24840-24841 NN denotes B
T9896 24842-24847 NN denotes cells
T9897 24849-24853 NN denotes LMP1
T9898 24854-24864 JJ denotes transgenic
T9899 24865-24866 NN denotes B
T9900 24867-24872 NN denotes cells
T9901 24873-24876 VB denotes had
T9902 24877-24886 VB denotes increased
T9903 24887-24893 NN denotes levels
T9904 24894-24896 IN denotes of
T9905 24897-24901 NN denotes pAkt
T9906 24902-24910 VB denotes compared
T9907 24911-24913 TO denotes to
T9908 24914-24923 JJ denotes wild-type
T9909 24924-24935 NN denotes lymphocytes
T9910 24935-24936 -COLON- denotes ;
T9911 24937-24944 RB denotes however
T9912 24944-24945 -COMMA- denotes ,
T9913 24946-24957 NN denotes progression
T9914 24958-24960 TO denotes to
T9915 24961-24969 NN denotes lymphoma
T9916 24970-24972 IN denotes in
T9917 24973-24977 CC denotes both
T9918 24978-24991 JJ denotes LMP1-positive
T9919 24992-24995 CC denotes and
T9920 24996-25005 JJ denotes -negative
T9921 25006-25014 NN denotes lymphoma
T9922 25015-25020 NN denotes cells
T9923 25021-25024 VB denotes did
T9924 25025-25028 RB denotes not
T9925 25029-25036 RB denotes further
T9926 25037-25045 VB denotes increase
T9927 25046-25050 NN denotes pAkt
T9928 25051-25057 NN denotes levels
T9929 25059-25062 DT denotes The
T9930 25063-25066 NN denotes Akt
T9931 25067-25073 NN denotes target
T9932 25074-25082 NN denotes glycogen
T9933 25083-25091 NN denotes synthase
T9934 25092-25098 NN denotes kinase
T9935 25099-25100 CD denotes 3
T9936 25101-25102 -LRB- denotes (
T9937 25102-25106 NN denotes GSK3
T9938 25106-25107 -RRB- denotes )
T9939 25108-25110 VB denotes is
T9940 25111-25122 VB denotes inactivated
T9941 25123-25125 IN denotes by
T9942 25126-25141 NN denotes phosphorylation
T9943 25141-25142 -COLON- denotes ;
T9944 25143-25150 RB denotes however
T9945 25150-25151 -COMMA- denotes ,
T9946 25152-25161 VB denotes increased
T9947 25162-25176 VB denotes phosphorylated
T9948 25177-25181 NN denotes GSK3
T9949 25182-25185 VB denotes was
T9950 25186-25189 RB denotes not
T9951 25190-25198 VB denotes detected
T9952 25199-25201 IN denotes in
T9953 25202-25205 DT denotes the
T9954 25206-25216 JJ denotes transgenic
T9955 25217-25228 NN denotes lymphocytes
T9956 25229-25232 CC denotes and
T9957 25233-25236 VB denotes was
T9958 25237-25243 RB denotes almost
T9959 25244-25250 JJ denotes absent
T9960 25251-25253 IN denotes in
T9961 25254-25257 DT denotes the
T9962 25258-25266 NN denotes lymphoma
T9963 25267-25274 NN denotes samples
T9964 25275-25276 -LRB- denotes (
T9965 25276-25282 NN denotes Figure
T9966 25283-25285 NN denotes 6A
T9967 25285-25286 -RRB- denotes )
T9968 25288-25292 DT denotes This
T9969 25293-25300 NN denotes finding
T9970 25301-25310 VB denotes indicates
T9971 25311-25315 IN denotes that
T9972 25316-25320 NN denotes GSK3
T9973 25321-25323 VB denotes is
T9974 25324-25327 RB denotes not
T9975 25328-25329 DT denotes a
T9976 25330-25336 NN denotes target
T9977 25337-25339 IN denotes of
T9978 25340-25349 VB denotes activated
T9979 25350-25353 NN denotes Akt
T9980 25354-25356 IN denotes in
T9981 25357-25360 DT denotes the
T9982 25361-25365 NN denotes LMP1
T9983 25366-25376 JJ denotes transgenic
T9984 25377-25388 NN denotes lymphocytes
T9985 25389-25392 CC denotes and
T9986 25393-25401 NN denotes lymphoma
T9987 25402-25407 NN denotes cells
T9988 25409-25418 RB denotes Similarly
T9989 25418-25419 -COMMA- denotes ,
T9990 25420-25430 NN denotes activation
T9991 25431-25433 IN denotes of
T9992 25434-25437 NN denotes Akt
T9993 25438-25445 IN denotes without
T9994 25446-25461 NN denotes phosphorylation
T9995 25462-25464 IN denotes of
T9996 25465-25469 NN denotes GSK3
T9997 25470-25473 VB denotes has
T9998 25474-25478 VB denotes been
T9999 25479-25489 RB denotes previously
T10000 25490-25495 VB denotes shown
T10001 25496-25498 IN denotes in
T10002 25499-25511 JJ denotes EBV-positive
T10003 25512-25514 NN denotes HD
T10004 25515-25516 -LRB- denotes [
T10005 25516-25518 CD denotes 40
T10006 25518-25519 -RRB- denotes ]
T10007 25521-25523 IN denotes In
T10008 25524-25532 NN denotes contrast
T10009 25532-25533 -COMMA- denotes ,
T10010 25534-25537 DT denotes the
T10011 25538-25547 JJ denotes wild-type
T10012 25548-25559 NN denotes lymphocytes
T10013 25560-25566 VB denotes lacked
T10014 25567-25576 VB denotes activated
T10015 25577-25580 NN denotes Akt
T10016 25581-25584 CC denotes but
T10017 25585-25588 VB denotes did
T10018 25589-25593 VB denotes have
T10019 25594-25604 JJ denotes detectable
T10020 25605-25619 VB denotes phosphorylated
T10021 25620-25624 NN denotes GSK3
T10022 25626-25630 DT denotes This
T10023 25631-25638 RB denotes further
T10024 25639-25647 VB denotes suggests
T10025 25648-25652 IN denotes that
T10026 25653-25663 JJ denotes additional
T10027 25664-25672 NN denotes pathways
T10028 25673-25676 VB denotes are
T10029 25677-25685 VB denotes involved
T10030 25686-25688 IN denotes in
T10031 25689-25692 DT denotes the
T10032 25693-25703 NN denotes regulation
T10033 25704-25706 IN denotes of
T10034 25707-25711 NN denotes GSK3
T10035 26382-26384 TO denotes To
T10036 26385-26393 VB denotes identify
T10037 26394-26399 JJ denotes other
T10038 26400-26409 JJ denotes potential
T10039 26410-26413 NN denotes Akt
T10040 26414-26421 NN denotes targets
T10041 26421-26422 -COMMA- denotes ,
T10042 26423-26433 NN denotes immunoblot
T10043 26434-26442 NN denotes analysis
T10044 26443-26446 IN denotes for
T10045 26447-26453 NN denotes p-mTOR
T10046 26454-26457 VB denotes was
T10047 26458-26467 VB denotes performed
T10048 26469-26478 VB denotes Activated
T10049 26479-26485 NN denotes p-mTOR
T10050 26486-26489 VB denotes was
T10051 26490-26493 RB denotes not
T10052 26494-26503 VB denotes increased
T10053 26504-26506 IN denotes in
T10054 26507-26511 NN denotes LMP1
T10055 26512-26522 JJ denotes transgenic
T10056 26523-26534 NN denotes lymphocytes
T10057 26535-26537 CC denotes or
T10058 26538-26546 NN denotes lymphoma
T10059 26547-26552 NN denotes cells
T10060 26552-26553 -COMMA- denotes ,
T10061 26554-26564 VB denotes indicating
T10062 26565-26569 IN denotes that
T10063 26570-26574 DT denotes this
T10064 26575-26582 NN denotes pathway
T10065 26583-26585 VB denotes is
T10066 26586-26589 RB denotes not
T10067 26590-26598 VB denotes affected
T10068 26599-26601 IN denotes by
T10069 26602-26614 JJ denotes LMP1-induced
T10070 26615-26618 NN denotes Akt
T10071 26619-26629 NN denotes activation
T10072 26630-26633 CC denotes and
T10073 26634-26638 VB denotes does
T10074 26639-26642 RB denotes not
T10075 26643-26653 VB denotes contribute
T10076 26654-26656 TO denotes to
T10077 26657-26665 NN denotes lymphoma
T10078 26666-26677 NN denotes development
T10079 26678-26679 -LRB- denotes (
T10080 26679-26685 NN denotes Figure
T10081 26686-26688 NN denotes 6B
T10082 26688-26689 -RRB- denotes )
T10083 26691-26694 NN denotes Akt
T10084 26695-26697 VB denotes is
T10085 26698-26702 RB denotes also
T10086 26703-26708 VB denotes known
T10087 26709-26711 TO denotes to
T10088 26712-26725 VB denotes phosphorylate
T10089 26726-26729 CC denotes and
T10090 26730-26736 VB denotes induce
T10091 26737-26740 DT denotes the
T10092 26741-26752 NN denotes degradation
T10093 26753-26755 IN denotes of
T10094 26756-26759 DT denotes the
T10095 26760-26773 JJ denotes pro-apoptotic
T10096 26774-26782 NN denotes Forkhead
T10097 26783-26789 NN denotes family
T10098 26790-26792 IN denotes of
T10099 26793-26806 NN denotes transcription
T10100 26807-26814 NN denotes factors
T10101 26814-26815 -COMMA- denotes ,
T10102 26816-26823 VB denotes leading
T10103 26824-26826 TO denotes to
T10104 26827-26831 NN denotes cell
T10105 26832-26837 NN denotes cycle
T10106 26838-26849 NN denotes progression
T10107 26850-26853 CC denotes and
T10108 26854-26862 NN denotes survival
T10109 26863-26865 IN denotes in
T10110 26866-26870 DT denotes some
T10111 26871-26876 JJ denotes human
T10112 26877-26883 NN denotes tumors
T10113 26884-26885 -LRB- denotes [
T10114 26885-26890 CD denotes 41,42
T10115 26890-26891 -RRB- denotes ]
T10116 26893-26903 NN denotes Immunoblot
T10117 26904-26912 NN denotes analysis
T10118 26913-26915 IN denotes of
T10119 26916-26923 JJ denotes splenic
T10120 26924-26925 NN denotes B
T10121 26926-26931 NN denotes cells
T10122 26932-26935 VB denotes did
T10123 26936-26939 RB denotes not
T10124 26940-26952 RB denotes consistently
T10125 26953-26959 VB denotes detect
T10126 26960-26967 NN denotes p-FoxO1
T10127 26968-26974 NN denotes levels
T10128 26974-26975 -COMMA- denotes ,
T10129 26976-26977 DT denotes a
T10130 26978-26984 NN denotes signal
T10131 26985-26989 WDT denotes that
T10132 26990-26997 VB denotes targets
T10133 26998-27003 NN denotes FoxO1
T10134 27004-27007 IN denotes for
T10135 27008-27019 NN denotes degradation
T10136 27021-27026 RB denotes Hence
T10137 27026-27027 -COMMA- denotes ,
T10138 27028-27039 NN denotes degradation
T10139 27040-27042 IN denotes of
T10140 27043-27048 NN denotes FoxO1
T10141 27049-27052 VB denotes was
T10142 27053-27061 VB denotes assessed
T10143 27062-27064 IN denotes by
T10144 27065-27074 NN denotes detection
T10145 27075-27077 IN denotes of
T10146 27078-27083 JJ denotes total
T10147 27084-27089 NN denotes FoxO1
T10148 27090-27096 NN denotes levels
T10149 27098-27108 NN denotes Immunoblot
T10150 27109-27117 NN denotes analysis
T10151 27118-27127 VB denotes indicated
T10152 27128-27132 IN denotes that
T10153 27133-27138 JJ denotes total
T10154 27139-27144 NN denotes FoxO1
T10155 27145-27151 NN denotes levels
T10156 27152-27156 VB denotes were
T10157 27157-27164 RB denotes greatly
T10158 27165-27174 VB denotes decreased
T10159 27175-27177 IN denotes in
T10160 27178-27187 JJ denotes wild-type
T10161 27188-27191 CC denotes and
T10162 27192-27196 NN denotes LMP1
T10163 27197-27207 JJ denotes transgenic
T10164 27208-27217 NN denotes lymphomas
T10165 27218-27219 -LRB- denotes (
T10166 27219-27225 NN denotes Figure
T10167 27226-27228 NN denotes 6B
T10168 27228-27229 -RRB- denotes )
T10169 27229-27230 -COMMA- denotes ,
T10170 27231-27241 VB denotes suggesting
T10171 27242-27246 IN denotes that
T10172 27247-27257 NN denotes inhibition
T10173 27258-27260 IN denotes of
T10174 27261-27264 DT denotes the
T10175 27265-27273 NN denotes Forkhead
T10176 27274-27283 NN denotes signaling
T10177 27284-27291 NN denotes pathway
T10178 27292-27294 VB denotes is
T10179 27295-27297 DT denotes an
T10180 27298-27307 JJ denotes important
T10181 27308-27314 NN denotes target
T10182 27315-27317 IN denotes of
T10183 27318-27321 NN denotes Akt
T10184 27322-27324 IN denotes in
T10185 27325-27333 NN denotes lymphoma
T10186 27334-27345 NN denotes development
T10187 27347-27354 RB denotes However
T10188 27354-27355 -COMMA- denotes ,
T10189 27356-27367 VB denotes considering
T10190 27368-27372 IN denotes that
T10191 27373-27376 NN denotes Akt
T10192 27377-27387 NN denotes activation
T10193 27388-27391 VB denotes did
T10194 27392-27395 RB denotes not
T10195 27396-27402 VB denotes induce
T10196 27403-27408 NN denotes FoxO1
T10197 27409-27420 NN denotes degradation
T10198 27421-27423 IN denotes in
T10199 27424-27428 NN denotes LMP1
T10200 27429-27439 JJ denotes transgenic
T10201 27440-27441 NN denotes B
T10202 27442-27447 NN denotes cells
T10203 27447-27448 -COMMA- denotes ,
T10204 27449-27452 NN denotes Akt
T10205 27453-27456 MD denotes may
T10206 27457-27460 RB denotes not
T10207 27461-27463 VB denotes be
T10208 27464-27467 DT denotes the
T10209 27468-27472 JJ denotes sole
T10210 27473-27482 NN denotes regulator
T10211 27483-27485 IN denotes of
T10212 27486-27491 NN denotes FoxO1
T10213 27491-27492 -COMMA- denotes ,
T10214 27493-27496 CC denotes and
T10215 27497-27499 PRP denotes it
T10216 27500-27503 MD denotes may
T10217 27504-27506 VB denotes be
T10218 27507-27511 DT denotes that
T10219 27512-27523 NN denotes progression
T10220 27524-27526 TO denotes to
T10221 27527-27535 NN denotes lymphoma
T10222 27536-27544 VB denotes requires
T10223 27545-27555 NN denotes modulation
T10224 27556-27558 IN denotes of
T10225 27559-27567 JJ denotes multiple
T10226 27568-27576 NN denotes pathways
T10227 27578-27581 DT denotes The
T10228 27582-27590 NNP denotes Forkhead
T10229 27591-27597 NN denotes family
T10230 27598-27600 IN denotes of
T10231 27601-27614 NN denotes transcription
T10232 27615-27622 NN denotes factors
T10233 27623-27625 VB denotes is
T10234 27626-27631 VB denotes known
T10235 27632-27634 TO denotes to
T10236 27635-27641 VB denotes induce
T10237 27642-27645 DT denotes the
T10238 27646-27656 NN denotes expression
T10239 27657-27659 IN denotes of
T10240 27660-27663 DT denotes the
T10241 27664-27667 NN denotes Cdk
T10242 27668-27677 NN denotes inhibitor
T10243 27678-27681 NN denotes p27
T10244 27682-27683 -LRB- denotes [
T10245 27683-27688 CD denotes 43,44
T10246 27688-27689 -RRB- denotes ]
T10247 27691-27707 JJ denotes LMP1-transformed
T10248 27708-27714 NN denotes rodent
T10249 27715-27726 NN denotes fibroblasts
T10250 27727-27731 VB denotes have
T10251 27732-27741 VB denotes decreased
T10252 27742-27752 NN denotes expression
T10253 27753-27755 IN denotes of
T10254 27756-27759 NN denotes p27
T10255 27759-27760 -COMMA- denotes ,
T10256 27761-27773 NN denotes upregulation
T10257 27774-27776 IN denotes of
T10258 27777-27781 NN denotes Cdk2
T10259 27781-27782 -COMMA- denotes ,
T10260 27783-27786 CC denotes and
T10261 27787-27797 JJ denotes subsequent
T10262 27798-27813 NN denotes phosphorylation
T10263 27814-27817 CC denotes and
T10264 27818-27830 NN denotes inactivation
T10265 27831-27833 IN denotes of
T10266 27834-27837 DT denotes the
T10267 27838-27843 NN denotes tumor
T10268 27844-27854 NN denotes suppressor
T10269 27855-27859 NN denotes gene
T10270 27860-27862 NN denotes Rb
T10271 27863-27864 -LRB- denotes [
T10272 27864-27866 CD denotes 45
T10273 27866-27867 -RRB- denotes ]
T10274 27869-27871 TO denotes To
T10275 27872-27883 VB denotes investigate
T10276 27884-27891 IN denotes whether
T10277 27892-27896 NN denotes LMP1
T10278 27897-27905 VB denotes affected
T10279 27906-27910 NN denotes cell
T10280 27911-27916 NN denotes cycle
T10281 27917-27927 NN denotes regulation
T10282 27928-27935 IN denotes through
T10283 27936-27939 DT denotes the
T10284 27940-27942 NN denotes Rb
T10285 27943-27950 NN denotes pathway
T10286 27951-27953 IN denotes in
T10287 27954-27955 NN denotes B
T10288 27956-27961 NN denotes cells
T10289 27961-27962 -COMMA- denotes ,
T10290 27963-27973 NN denotes immunoblot
T10291 27974-27982 NN denotes analyses
T10292 27983-27986 IN denotes for
T10293 27987-27990 NN denotes pRb
T10294 27990-27991 -COMMA- denotes ,
T10295 27992-27996 NN denotes Cdk2
T10296 27996-27997 -COMMA- denotes ,
T10297 27998-28001 CC denotes and
T10298 28002-28005 NN denotes p27
T10299 28006-28010 VB denotes were
T10300 28011-28020 VB denotes performed
T10301 28021-28023 IN denotes on
T10302 28024-28031 JJ denotes splenic
T10303 28032-28037 JJ denotes CD19+
T10304 28038-28051 JJ denotes MACS-purified
T10305 28052-28053 NN denotes B
T10306 28054-28059 NN denotes cells
T10307 28061-28065 NN denotes LMP1
T10308 28066-28076 JJ denotes transgenic
T10309 28077-28078 NN denotes B
T10310 28079-28084 NN denotes cells
T10311 28085-28088 VB denotes had
T10312 28089-28097 VB denotes enhanced
T10313 28098-28104 NN denotes levels
T10314 28105-28107 IN denotes of
T10315 28108-28111 NN denotes pRb
T10316 28112-28116 IN denotes with
T10317 28117-28128 JJ denotes concomitant
T10318 28129-28142 NN denotes stabilization
T10319 28143-28145 IN denotes of
T10320 28146-28151 JJ denotes total
T10321 28152-28154 NN denotes Rb
T10322 28155-28161 NN denotes levels
T10323 28162-28165 CC denotes and
T10324 28166-28170 NN denotes Cdk2
T10325 28171-28179 VB denotes compared
T10326 28180-28182 TO denotes to
T10327 28183-28192 JJ denotes wild-type
T10328 28193-28194 NN denotes B
T10329 28195-28206 NN denotes lymphocytes
T10330 28207-28208 -LRB- denotes (
T10331 28208-28214 NN denotes Figure
T10332 28215-28217 NN denotes 6C
T10333 28217-28218 -RRB- denotes )
T10334 28220-28231 NN denotes Progression
T10335 28232-28234 TO denotes to
T10336 28235-28243 NN denotes lymphoma
T10337 28244-28246 IN denotes in
T10338 28247-28251 CC denotes both
T10339 28252-28261 JJ denotes wild-type
T10340 28262-28265 CC denotes and
T10341 28266-28270 NN denotes LMP1
T10342 28271-28281 JJ denotes transgenic
T10343 28282-28290 NN denotes lymphoma
T10344 28291-28296 NN denotes cells
T10345 28297-28300 VB denotes led
T10346 28301-28303 TO denotes to
T10347 28304-28313 VB denotes increased
T10348 28314-28320 NN denotes levels
T10349 28321-28323 IN denotes of
T10350 28324-28326 NN denotes Rb
T10351 28326-28327 -COMMA- denotes ,
T10352 28328-28343 RB denotes correspondingly
T10353 28344-28348 JJ denotes high
T10354 28349-28355 NN denotes levels
T10355 28356-28358 IN denotes of
T10356 28359-28363 NN denotes Cdk2
T10357 28363-28364 -COMMA- denotes ,
T10358 28365-28368 CC denotes and
T10359 28369-28378 VB denotes decreased
T10360 28379-28385 NN denotes levels
T10361 28386-28388 IN denotes of
T10362 28389-28392 NN denotes p27
T10363 28393-28394 -LRB- denotes (
T10364 28394-28400 NN denotes Figure
T10365 28401-28403 NN denotes 6C
T10366 28403-28404 -RRB- denotes )
T10367 28406-28411 DT denotes These
T10368 28412-28416 NN denotes data
T10369 28417-28425 VB denotes indicate
T10370 28426-28430 IN denotes that
T10371 28431-28434 DT denotes the
T10372 28435-28437 NN denotes Rb
T10373 28438-28445 NN denotes pathway
T10374 28446-28448 VB denotes is
T10375 28449-28460 VB denotes deregulated
T10376 28461-28463 IN denotes in
T10377 28464-28468 NN denotes LMP1
T10378 28469-28479 JJ denotes transgenic
T10379 28480-28491 NN denotes lymphocytes
T10380 28492-28495 CC denotes and
T10381 28496-28500 IN denotes that
T10382 28501-28509 NN denotes lymphoma
T10383 28510-28515 NN denotes cells
T10384 28516-28519 VB denotes are
T10385 28520-28533 VB denotes distinguished
T10386 28534-28536 IN denotes by
T10387 28537-28541 NN denotes loss
T10388 28542-28544 IN denotes of
T10389 28545-28550 NN denotes FoxO1
T10390 28551-28554 CC denotes and
T10391 28555-28564 VB denotes decreased
T10392 28565-28568 NN denotes p27
T11981 29052-29055 DT denotes the
T11897 28571-28575 NN denotes LMP1
T11898 28576-28584 VB denotes Promotes
T11899 28585-28590 NN denotes Tumor
T11900 28591-28597 NN denotes Growth
T11901 28598-28601 CC denotes and
T11902 28602-28610 NN denotes Survival
T11903 28611-28618 IN denotes through
T11904 28619-28629 NN denotes Activation
T11905 28630-28632 IN denotes of
T11906 28633-28636 NN denotes Akt
T11907 28636-28637 -COMMA- denotes ,
T11908 28638-28642 NN denotes NFκB
T11909 28642-28643 -COMMA- denotes ,
T11910 28644-28647 CC denotes and
T11911 28648-28653 NN denotes Stat3
T11912 28654-28662 NN denotes Pathways
T11913 28663-28665 TO denotes To
T11914 28666-28673 VB denotes explore
T11915 28674-28679 WDT denotes which
T11916 28680-28688 NN denotes pathways
T11917 28689-28693 VB denotes were
T11918 28694-28702 VB denotes required
T11919 28703-28706 IN denotes for
T11920 28707-28710 DT denotes the
T11921 28711-28719 VB denotes enhanced
T11922 28720-28726 NN denotes growth
T11923 28727-28730 CC denotes and
T11924 28731-28739 NN denotes survival
T11925 28740-28742 IN denotes of
T11926 28743-28755 JJ denotes LMP1-induced
T11927 28756-28765 NN denotes lymphomas
T11928 28765-28766 -COMMA- denotes ,
T11929 28767-28778 NN denotes splenocytes
T11930 28779-28783 IN denotes from
T11931 28784-28793 JJ denotes wild-type
T11932 28794-28797 CC denotes and
T11933 28798-28802 NN denotes LMP1
T11934 28803-28813 JJ denotes transgenic
T11935 28814-28818 NN denotes mice
T11936 28819-28823 VB denotes were
T11937 28824-28832 VB denotes cultured
T11938 28833-28835 IN denotes in
T11939 28836-28839 DT denotes the
T11940 28840-28848 NN denotes presence
T11941 28849-28851 IN denotes of
T11942 28852-28862 NN denotes inhibitors
T11943 28863-28866 IN denotes for
T11944 28867-28870 NN denotes Akt
T11945 28870-28871 -COMMA- denotes ,
T11946 28872-28876 NN denotes NFκB
T11947 28876-28877 -COMMA- denotes ,
T11948 28878-28883 NN denotes Stat3
T11949 28883-28884 -COMMA- denotes ,
T11950 28885-28889 NN denotes mTOR
T11951 28889-28890 -COMMA- denotes ,
T11952 28891-28893 CC denotes or
T11953 28894-28898 NN denotes MAPK
T11954 28899-28902 CC denotes and
T11955 28903-28910 VB denotes assayed
T11956 28911-28914 IN denotes for
T11957 28915-28921 NN denotes growth
T11958 28922-28925 CC denotes and
T11959 28926-28934 NN denotes survival
T11960 28935-28937 IN denotes by
T11961 28938-28941 DT denotes the
T11962 28942-28945 NN denotes MTS
T11963 28946-28951 NN denotes assay
T11964 28953-28955 IN denotes As
T11965 28956-28966 RB denotes previously
T11966 28967-28972 VB denotes shown
T11967 28972-28973 -COMMA- denotes ,
T11968 28974-28983 JJ denotes wild-type
T11969 28984-28995 NN denotes lymphocytes
T11970 28996-29000 VB denotes were
T11971 29001-29004 RB denotes not
T11972 29005-29011 JJ denotes viable
T11973 29012-29014 IN denotes in
T11974 29015-29022 NN denotes culture
T11975 29023-29026 CC denotes and
T11976 29027-29032 MD denotes could
T11977 29033-29036 RB denotes not
T11978 29037-29039 VB denotes be
T11979 29040-29046 VB denotes tested
T11980 29047-29051 IN denotes with
T11982 29056-29066 NN denotes inhibitors
T11983 29068-29075 RB denotes However
T11984 29075-29076 -COMMA- denotes ,
T11985 29077-29080 DT denotes the
T11986 29081-29089 VB denotes enhanced
T11987 29090-29099 NN denotes viability
T11988 29100-29102 IN denotes of
T11989 29103-29107 NN denotes LMP1
T11990 29108-29118 JJ denotes transgenic
T11991 29119-29130 NN denotes lymphocytes
T11992 29131-29134 VB denotes was
T11993 29135-29146 RB denotes effectively
T11994 29147-29154 VB denotes blocked
T11995 29155-29157 IN denotes by
T11996 29158-29167 NN denotes treatment
T11997 29168-29172 IN denotes with
T11998 29173-29184 NN denotes triciribine
T11999 29184-29185 -COMMA- denotes ,
T12000 29186-29196 NN denotes BAY11–7085
T12001 29196-29197 -COMMA- denotes ,
T12002 29198-29210 NN denotes cucurbitacin
T12003 29211-29212 NN denotes I
T12004 29212-29213 -COMMA- denotes ,
T12005 29214-29217 CC denotes and
T12006 29218-29226 RB denotes slightly
T12007 29227-29231 IN denotes with
T12008 29232-29240 NN denotes SB203580
T12009 29240-29241 -COMMA- denotes ,
T12010 29242-29245 CC denotes but
T12011 29246-29249 RB denotes not
T12012 29250-29252 IN denotes by
T12013 29253-29262 NN denotes treatment
T12014 29263-29267 IN denotes with
T12015 29268-29277 NN denotes rapamycin
T12016 29277-29278 -COMMA- denotes ,
T12017 29279-29284 NN denotes U0126
T12018 29284-29285 -COMMA- denotes ,
T12019 29286-29288 CC denotes or
T12020 29289-29294 NN denotes AG490
T12021 29295-29296 -LRB- denotes (
T12022 29296-29302 NN denotes Figure
T12023 29303-29304 CD denotes 7
T12024 29304-29305 -RRB- denotes )
T12025 29307-29318 NN denotes Triciribine
T12026 29319-29327 VB denotes inhibits
T12027 29328-29331 DT denotes the
T12028 29332-29342 NN denotes activation
T12029 29343-29345 IN denotes of
T12030 29346-29349 NN denotes Akt
T12031 29350-29353 CC denotes and
T12032 29354-29356 IN denotes at
T12033 29357-29359 CD denotes 20
T12034 29360-29362 NN denotes μM
T12035 29363-29366 VB denotes has
T12036 29367-29371 VB denotes been
T12037 29372-29377 VB denotes shown
T12038 29378-29380 TO denotes to
T12039 29381-29387 VB denotes induce
T12040 29388-29394 NN denotes growth
T12041 29395-29401 NN denotes arrest
T12042 29402-29404 IN denotes in
T12043 29405-29411 NN denotes cancer
T12044 29412-29417 NN denotes cells
T12045 29418-29422 IN denotes with
T12046 29423-29431 JJ denotes aberrant
T12047 29432-29435 NN denotes Akt
T12048 29436-29444 NN denotes activity
T12049 29445-29446 -LRB- denotes [
T12050 29446-29448 CD denotes 46
T12051 29448-29449 -RRB- denotes ]
T12052 29451-29454 DT denotes The
T12053 29455-29462 NN denotes effects
T12054 29463-29465 IN denotes of
T12055 29466-29477 NN denotes triciribine
T12056 29478-29480 IN denotes on
T12057 29481-29485 NN denotes cell
T12058 29486-29492 NN denotes growth
T12059 29493-29495 IN denotes of
T12060 29496-29499 DT denotes the
T12061 29500-29510 JJ denotes transgenic
T12062 29511-29522 NN denotes lymphocytes
T12063 29523-29526 CC denotes and
T12064 29527-29536 NN denotes lymphomas
T12065 29537-29541 VB denotes were
T12066 29542-29550 JJ denotes apparent
T12067 29551-29553 RB denotes as
T12068 29554-29557 JJ denotes low
T12069 29558-29560 IN denotes as
T12070 29561-29562 CD denotes 1
T12071 29563-29565 NN denotes μM
T12072 29565-29566 -COMMA- denotes ,
T12073 29567-29577 VB denotes suggesting
T12074 29578-29582 IN denotes that
T12075 29583-29593 NN denotes activation
T12076 29594-29596 IN denotes of
T12077 29597-29600 NN denotes Akt
T12078 29601-29603 VB denotes is
T12079 29604-29612 VB denotes required
T12080 29613-29616 IN denotes for
T12081 29617-29620 DT denotes the
T12082 29621-29629 NN denotes survival
T12083 29630-29633 CC denotes and
T12084 29634-29640 NN denotes growth
T12085 29641-29643 IN denotes of
T12086 29644-29648 NN denotes LMP1
T12087 29649-29659 JJ denotes transgenic
T12088 29660-29671 NN denotes lymphocytes
T12089 29672-29675 CC denotes and
T12090 29676-29684 NN denotes lymphoma
T12091 29685-29690 NN denotes cells
T12092 29691-29692 -LRB- denotes (
T12093 29692-29698 NN denotes Figure
T12094 29699-29700 CD denotes 7
T12095 29700-29701 -RRB- denotes )
T12096 29703-29706 DT denotes The
T12097 29707-29714 NN denotes effects
T12098 29715-29717 IN denotes of
T12099 29718-29721 DT denotes the
T12100 29722-29732 NN denotes inhibitors
T12101 29733-29737 VB denotes were
T12102 29738-29746 VB denotes assessed
T12103 29747-29749 IN denotes by
T12104 29750-29761 VB denotes identifying
T12105 29762-29776 VB denotes phosphorylated
T12106 29777-29780 NN denotes Akt
T12107 29780-29781 -COMMA- denotes ,
T12108 29782-29787 NN denotes Stat3
T12109 29787-29788 -COMMA- denotes ,
T12110 29789-29792 CC denotes and
T12111 29793-29798 JJ denotes total
T12112 29799-29805 NN denotes levels
T12113 29806-29808 IN denotes of
T12114 29809-29813 NN denotes IκBα
T12115 29814-29815 -LRB- denotes (
T12116 29815-29821 NN denotes Figure
T12117 29822-29823 CD denotes 8
T12118 29823-29824 -RRB- denotes )
T12119 29826-29835 NN denotes Treatment
T12120 29836-29840 IN denotes with
T12121 29841-29852 NN denotes triciribine
T12122 29853-29864 RB denotes effectively
T12123 29865-29872 VB denotes blocked
T12124 29873-29888 NN denotes phosphorylation
T12125 29889-29891 IN denotes of
T12126 29892-29895 NN denotes Akt
T12127 29895-29896 -COMMA- denotes ,
T12128 29897-29900 CC denotes and
T12129 29901-29915 VB denotes phosphorylated
T12130 29916-29919 NN denotes Akt
T12131 29920-29923 VB denotes was
T12132 29924-29926 RB denotes no
T12133 29927-29933 RB denotes longer
T12134 29934-29942 VB denotes detected
T12135 29943-29947 IN denotes past
T12136 29948-29949 CD denotes 5
T12137 29950-29952 NN denotes μM
T12138 29954-29968 VB denotes Phosphorylated
T12139 29969-29974 NN denotes Stat3
T12140 29975-29978 CC denotes and
T12141 29979-29983 NN denotes IκBα
T12142 29984-29988 VB denotes were
T12143 29989-29994 RB denotes still
T12144 29995-30002 JJ denotes present
T12145 30003-30005 IN denotes at
T12146 30006-30008 CD denotes 25
T12147 30009-30011 NN denotes μM
T12148 30013-30018 DT denotes These
T12149 30019-30027 NN denotes findings
T12150 30028-30035 VB denotes suggest
T12151 30036-30040 IN denotes that
T12152 30041-30052 NN denotes triciribine
T12153 30053-30065 RB denotes specifically
T12154 30066-30073 VB denotes targets
T12155 30074-30077 NN denotes Akt
T12156 30078-30081 CC denotes and
T12157 30082-30086 IN denotes that
T12158 30087-30090 NN denotes Akt
T12159 30091-30101 NN denotes activation
T12160 30102-30104 VB denotes is
T12161 30105-30113 VB denotes required
T12162 30114-30117 IN denotes for
T12163 30118-30121 DT denotes the
T12164 30122-30130 VB denotes enhanced
T12165 30131-30140 NN denotes viability
T12166 30141-30143 IN denotes of
T12167 30144-30147 DT denotes the
T12168 30148-30158 JJ denotes transgenic
T12169 30159-30170 NN denotes lymphocytes
T12170 30171-30174 CC denotes and
T12171 30175-30183 NN denotes lymphoma
T12172 30184-30189 NN denotes cells
T12173 31411-31421 NN denotes Inhibition
T12174 31422-31424 IN denotes of
T12175 31425-31429 NN denotes NFκB
T12176 31430-31439 NN denotes signaling
T12177 31440-31447 RB denotes rapidly
T12178 31448-31455 VB denotes induces
T12179 31456-31460 NN denotes cell
T12180 31461-31466 NN denotes death
T12181 31467-31469 IN denotes of
T12182 31470-31485 JJ denotes EBV-transformed
T12183 31486-31497 NN denotes lymphocytes
T12184 31498-31499 -LRB- denotes [
T12185 31499-31504 CD denotes 17,18
T12186 31504-31505 -RRB- denotes ]
T12187 31507-31517 NN denotes BAY11–7085
T12188 31517-31518 -COMMA- denotes ,
T12189 31519-31521 DT denotes an
T12190 31522-31531 NN denotes inhibitor
T12191 31532-31534 IN denotes of
T12192 31535-31539 NN denotes NFκB
T12193 31540-31549 NN denotes signaling
T12194 31549-31550 -COMMA- denotes ,
T12195 31551-31555 RB denotes also
T12196 31556-31563 RB denotes greatly
T12197 31564-31573 VB denotes decreased
T12198 31574-31577 DT denotes the
T12199 31578-31587 NN denotes viability
T12200 31588-31590 IN denotes of
T12201 31591-31594 DT denotes the
T12202 31595-31599 NN denotes LMP1
T12203 31600-31610 JJ denotes transgenic
T12204 31611-31622 NN denotes lymphocytes
T12205 31623-31626 CC denotes and
T12206 31627-31635 NN denotes lymphoma
T12207 31636-31641 NN denotes cells
T12208 31642-31644 IN denotes at
T12209 31645-31650 NN denotes doses
T12210 31651-31653 RB denotes as
T12211 31654-31657 JJ denotes low
T12212 31658-31660 IN denotes as
T12213 31661-31662 CD denotes 1
T12214 31663-31665 NN denotes μM
T12215 31665-31666 -COMMA- denotes ,
T12216 31667-31670 CC denotes and
T12217 31671-31673 IN denotes at
T12218 31674-31675 CD denotes 5
T12219 31676-31678 NN denotes μM
T12220 31679-31682 DT denotes the
T12221 31683-31688 NN denotes cells
T12222 31689-31693 VB denotes were
T12223 31694-31704 RB denotes completely
T12224 31705-31714 JJ denotes nonviable
T12225 31715-31716 -LRB- denotes (
T12226 31716-31722 NN denotes Figure
T12227 31723-31724 CD denotes 7
T12228 31724-31725 -RRB- denotes )
T12229 31727-31731 DT denotes This
T12230 31732-31734 VB denotes is
T12231 31735-31739 RB denotes well
T12232 31740-31746 IN denotes within
T12233 31747-31750 DT denotes the
T12234 31751-31759 VB denotes reported
T12235 31760-31764 NN denotes IC50
T12236 31765-31767 IN denotes of
T12237 31768-31770 CD denotes 10
T12238 31771-31773 NN denotes μM
T12239 31775-31789 VB denotes Phosphorylated
T12240 31790-31793 NN denotes Akt
T12241 31793-31794 -COMMA- denotes ,
T12242 31795-31800 NN denotes Stat3
T12243 31800-31801 -COMMA- denotes ,
T12244 31802-31805 CC denotes and
T12245 31806-31811 JJ denotes total
T12246 31812-31816 NN denotes IκBα
T12247 31817-31821 VB denotes were
T12248 31822-31827 RB denotes still
T12249 31828-31835 JJ denotes present
T12250 31836-31838 IN denotes up
T12251 31839-31841 TO denotes to
T12252 31842-31851 NN denotes treatment
T12253 31852-31856 IN denotes with
T12254 31857-31859 CD denotes 15
T12255 31860-31862 NN denotes μM
T12256 31863-31866 CC denotes and
T12257 31867-31871 RB denotes then
T12258 31872-31876 VB denotes were
T12259 31877-31879 RB denotes no
T12260 31880-31886 RB denotes longer
T12261 31887-31895 VB denotes detected
T12262 31896-31897 -LRB- denotes (
T12263 31897-31903 NN denotes Figure
T12264 31904-31905 CD denotes 8
T12265 31905-31906 -RRB- denotes )
T12266 31908-31912 DT denotes This
T12267 31913-31920 NN denotes finding
T12268 31921-31929 VB denotes suggests
T12269 31930-31934 IN denotes that
T12270 31935-31945 NN denotes inhibition
T12271 31946-31948 IN denotes of
T12272 31949-31953 NN denotes NFκB
T12273 31954-31957 MD denotes can
T12274 31958-31964 VB denotes induce
T12275 31965-31969 NN denotes cell
T12276 31970-31975 NN denotes death
T12277 31976-31978 IN denotes in
T12278 31979-31983 NN denotes LMP1
T12279 31984-31994 JJ denotes transgenic
T12280 31995-32006 NN denotes lymphocytes
T12281 32007-32010 CC denotes and
T12282 32011-32019 NN denotes lymphoma
T12283 32020-32025 NN denotes cells
T12284 32026-32033 IN denotes without
T12285 32034-32045 JJ denotes significant
T12286 32046-32053 NN denotes effects
T12287 32054-32056 IN denotes on
T12288 32057-32067 NN denotes activation
T12289 32068-32070 IN denotes of
T12290 32071-32074 NN denotes Akt
T12291 32075-32077 CC denotes or
T12292 32078-32083 NN denotes Stat3
T12293 32085-32097 NN denotes Cucurbitacin
T12294 32098-32099 PRP denotes I
T12295 32100-32108 VB denotes inhibits
T12296 32109-32119 NN denotes activation
T12297 32120-32122 IN denotes of
T12298 32123-32128 NN denotes Stat3
T12299 32129-32131 IN denotes by
T12300 32132-32143 VB denotes suppressing
T12301 32144-32147 DT denotes the
T12302 32148-32158 NN denotes activation
T12303 32159-32161 IN denotes of
T12304 32162-32165 PRP-DOLLAR- denotes its
T12305 32166-32172 NN denotes kinase
T12306 32173-32177 NN denotes JAK2
T12307 32179-32181 PRP denotes It
T12308 32182-32185 VB denotes has
T12309 32186-32190 VB denotes been
T12310 32191-32196 VB denotes shown
T12311 32197-32199 TO denotes to
T12312 32200-32211 RB denotes selectively
T12313 32212-32219 VB denotes inhibit
T12314 32220-32223 DT denotes the
T12315 32224-32230 NN denotes growth
T12316 32231-32233 IN denotes of
T12317 32234-32240 NN denotes tumors
T12318 32241-32245 IN denotes with
T12319 32246-32260 RB denotes constitutively
T12320 32261-32270 VB denotes activated
T12321 32271-32276 NN denotes Stat3
T12322 32277-32278 -LRB- denotes [
T12323 32278-32280 CD denotes 47
T12324 32280-32281 -RRB- denotes ]
T12325 32283-32292 RB denotes Similarly
T12326 32292-32293 -COMMA- denotes ,
T12327 32294-32298 NN denotes LMP1
T12328 32299-32309 JJ denotes transgenic
T12329 32310-32321 NN denotes lymphocytes
T12330 32322-32325 CC denotes and
T12331 32326-32334 NN denotes lymphoma
T12332 32335-32340 NN denotes cells
T12333 32341-32345 VB denotes were
T12334 32346-32357 JJ denotes susceptible
T12335 32358-32360 TO denotes to
T12336 32361-32373 NN denotes cucurbitacin
T12337 32374-32375 CD denotes I
T12338 32376-32385 NN denotes treatment
T12339 32386-32394 VB denotes starting
T12340 32395-32397 IN denotes at
T12341 32398-32401 CD denotes 0.1
T12342 32402-32404 NN denotes μM
T12343 32404-32405 -COMMA- denotes ,
T12344 32406-32407 DT denotes a
T12345 32408-32412 NN denotes dose
T12346 32413-32417 WDT denotes that
T12347 32418-32429 VB denotes corresponds
T12348 32430-32437 RB denotes closely
T12349 32438-32440 TO denotes to
T12350 32441-32444 DT denotes the
T12351 32445-32453 VB denotes reported
T12352 32454-32458 NN denotes IC50
T12353 32459-32461 IN denotes of
T12354 32462-32465 CD denotes 500
T12355 32466-32468 NN denotes nM
T12356 32469-32470 -LRB- denotes (
T12357 32470-32476 NN denotes Figure
T12358 32477-32478 CD denotes 7
T12359 32478-32479 -RRB- denotes )
T12360 32480-32481 -LRB- denotes [
T12361 32481-32483 CD denotes 47
T12362 32483-32484 -RRB- denotes ]
T12363 32486-32500 VB denotes Phosphorylated
T12364 32501-32504 NN denotes Akt
T12365 32504-32505 -COMMA- denotes ,
T12366 32506-32511 NN denotes Stat3
T12367 32511-32512 -COMMA- denotes ,
T12368 32513-32516 CC denotes and
T12369 32517-32522 JJ denotes total
T12370 32523-32527 NN denotes IκBα
T12371 32528-32532 VB denotes were
T12372 32533-32536 RB denotes not
T12373 32537-32547 JJ denotes detectable
T12374 32548-32552 IN denotes past
T12375 32553-32554 CD denotes 1
T12376 32555-32557 NN denotes μM
T12377 32558-32561 CC denotes and
T12378 32562-32564 IN denotes at
T12379 32565-32571 JJ denotes higher
T12380 32572-32577 NN denotes doses
T12381 32578-32581 DT denotes all
T12382 32582-32589 NN denotes protein
T12383 32590-32596 NN denotes levels
T12384 32597-32601 VB denotes were
T12385 32602-32609 RB denotes greatly
T12386 32610-32619 VB denotes decreased
T12387 32619-32620 -COMMA- denotes ,
T12388 32621-32631 JJ denotes indicative
T12389 32632-32634 IN denotes of
T12390 32635-32638 DT denotes the
T12391 32639-32644 JJ denotes total
T12392 32645-32649 NN denotes loss
T12393 32650-32652 IN denotes of
T12394 32653-32662 NN denotes viability
T12395 32663-32664 -LRB- denotes (
T12396 32664-32670 NN denotes Figure
T12397 32671-32672 CD denotes 8
T12398 32672-32673 -RRB- denotes )
T12399 32675-32676 DT denotes A
T12400 32677-32683 JJ denotes second
T12401 32684-32692 VB denotes reported
T12402 32693-32702 NN denotes inhibitor
T12403 32703-32705 IN denotes of
T12404 32706-32711 NN denotes Stat3
T12405 32711-32712 -COMMA- denotes ,
T12406 32713-32718 NN denotes AG490
T12407 32718-32719 -COMMA- denotes ,
T12408 32720-32723 VB denotes had
T12409 32724-32726 DT denotes no
T12410 32727-32733 NN denotes effect
T12411 32734-32736 IN denotes on
T12412 32737-32743 NN denotes growth
T12413 32744-32745 -LRB- denotes (
T12414 32745-32751 NN denotes Figure
T12415 32752-32753 CD denotes 7
T12416 32753-32754 -RRB- denotes )
T12417 32754-32755 -COMMA- denotes ,
T12418 32756-32759 CC denotes but
T12419 32760-32770 NN denotes activation
T12420 32771-32773 IN denotes of
T12421 32774-32777 NN denotes Akt
T12422 32777-32778 -COMMA- denotes ,
T12423 32779-32784 NN denotes Stat3
T12424 32784-32785 -COMMA- denotes ,
T12425 32786-32788 CC denotes or
T12426 32789-32795 NN denotes levels
T12427 32796-32798 IN denotes of
T12428 32799-32803 NN denotes IκBα
T12429 32804-32808 VB denotes were
T12430 32809-32813 RB denotes also
T12431 32814-32817 RB denotes not
T12432 32818-32826 VB denotes affected
T12433 32827-32828 -LRB- denotes (
T12434 32828-32834 NN denotes Figure
T12435 32835-32836 CD denotes 8
T12436 32836-32837 -RRB- denotes )
T12437 32839-32844 DT denotes These
T12438 32845-32853 NN denotes findings
T12439 32854-32861 VB denotes suggest
T12440 32862-32866 IN denotes that
T12441 32867-32877 NN denotes inhibition
T12442 32878-32880 IN denotes of
T12443 32881-32886 NN denotes Stat3
T12444 32887-32890 MD denotes can
T12445 32891-32897 VB denotes induce
T12446 32898-32902 NN denotes cell
T12447 32903-32908 NN denotes death
T12448 32909-32911 IN denotes in
T12449 32912-32916 NN denotes LMP1
T12450 32917-32927 JJ denotes transgenic
T12451 32928-32939 NN denotes lymphocytes
T12452 32940-32943 CC denotes and
T12453 32944-32952 NN denotes lymphoma
T12454 32953-32958 NN denotes cells
T12455 32958-32959 -COMMA- denotes ,
T12456 32960-32963 CC denotes but
T12457 32964-32969 NN denotes Stat3
T12458 32970-32980 NN denotes inhibition
T12459 32981-32985 RB denotes also
T12460 32986-32989 VB denotes has
T12461 32990-33002 JJ denotes considerable
T12462 33003-33012 JJ denotes crossover
T12463 33013-33020 NN denotes effects
T12464 33021-33023 IN denotes on
T12465 33024-33027 NN denotes Akt
T12466 33028-33031 CC denotes and
T12467 33032-33036 NN denotes NFκB
T12468 33037-33046 NN denotes signaling
T12469 33048-33052 NN denotes LMP1
T12470 33053-33056 VB denotes has
T12471 33057-33061 RB denotes also
T12472 33062-33066 VB denotes been
T12473 33067-33072 VB denotes shown
T12474 33073-33075 TO denotes to
T12475 33076-33084 VB denotes activate
T12476 33085-33088 NN denotes JNK
T12477 33089-33092 CC denotes and
T12478 33093-33096 NN denotes p38
T12479 33097-33101 NN denotes MAPK
T12480 33102-33110 NN denotes pathways
T12481 33111-33112 -LRB- denotes [
T12482 33112-33117 CD denotes 13,48
T12483 33117-33118 -RRB- denotes ]
T12484 33118-33119 -COMMA- denotes ,
T12485 33120-33123 CC denotes and
T12486 33124-33128 NN denotes LMP1
T12487 33129-33139 JJ denotes transgenic
T12488 33140-33151 NN denotes lymphocytes
T12489 33152-33156 VB denotes were
T12490 33157-33163 RB denotes mildly
T12491 33164-33175 JJ denotes susceptible
T12492 33176-33178 TO denotes to
T12493 33179-33185 NN denotes growth
T12494 33186-33196 NN denotes inhibition
T12495 33197-33199 IN denotes by
T12496 33200-33208 NN denotes SB202190
T12497 33208-33209 -COMMA- denotes ,
T12498 33210-33212 DT denotes an
T12499 33213-33222 NN denotes inhibitor
T12500 33223-33225 IN denotes of
T12501 33226-33229 NN denotes p38
T12502 33230-33234 NN denotes MAPK
T12503 33234-33235 -COMMA- denotes ,
T12504 33236-33239 CC denotes but
T12505 33240-33243 RB denotes not
T12506 33244-33249 NN denotes U0126
T12507 33249-33250 -COMMA- denotes ,
T12508 33251-33253 DT denotes an
T12509 33254-33263 NN denotes inhibitor
T12510 33264-33266 IN denotes of
T12511 33267-33273 NN denotes MEK1/2
T12512 33274-33282 NN denotes activity
T12513 33284-33291 RB denotes However
T12514 33291-33292 -COMMA- denotes ,
T12515 33293-33300 NN denotes effects
T12516 33301-33303 IN denotes of
T12517 33304-33312 NN denotes SB202190
T12518 33313-33317 VB denotes were
T12519 33318-33322 RB denotes only
T12520 33323-33331 JJ denotes apparent
T12521 33332-33334 IN denotes at
T12522 33335-33339 JJ denotes high
T12523 33340-33345 NN denotes doses
T12524 33346-33347 -LRB- denotes (
T12525 33347-33348 JJ denotes >
T12526 33348-33350 CD denotes 10
T12527 33351-33353 NN denotes μM
T12528 33353-33354 -RRB- denotes )
T12529 33354-33355 -COMMA- denotes ,
T12530 33356-33360 RB denotes much
T12531 33361-33367 JJ denotes higher
T12532 33368-33372 IN denotes than
T12533 33373-33376 DT denotes the
T12534 33377-33385 VB denotes reported
T12535 33386-33390 NN denotes IC50
T12536 33391-33393 IN denotes of
T12537 33394-33398 CD denotes 0.35
T12538 33399-33401 NN denotes μM
T12539 33401-33402 -COMMA- denotes ,
T12540 33403-33413 VB denotes suggesting
T12541 33414-33418 IN denotes that
T12542 33419-33422 NN denotes p38
T12543 33423-33427 NN denotes MAPK
T12544 33428-33432 VB denotes does
T12545 33433-33436 RB denotes not
T12546 33437-33450 RB denotes significantly
T12547 33451-33461 VB denotes contribute
T12548 33462-33464 TO denotes to
T12549 33465-33468 DT denotes the
T12550 33469-33477 VB denotes enhanced
T12551 33478-33487 NN denotes viability
T12552 33488-33490 IN denotes in
T12553 33491-33495 NN denotes LMP1
T12554 33496-33506 JJ denotes transgenic
T12555 33507-33518 NN denotes lymphocytes
T12556 33519-33521 CC denotes or
T12557 33522-33530 NN denotes lymphoma
T12558 33531-33536 NN denotes cells
T12559 33537-33538 -LRB- denotes (
T12560 33538-33544 NN denotes Figure
T12561 33545-33546 CD denotes 7
T12562 33546-33547 -RRB- denotes )
T12563 33549-33562 RB denotes Interestingly
T12564 33562-33563 -COMMA- denotes ,
T12565 33564-33568 CC denotes both
T12566 33569-33578 JJ denotes wild-type
T12567 33579-33582 CC denotes and
T12568 33583-33587 NN denotes LMP1
T12569 33588-33598 JJ denotes transgenic
T12570 33599-33608 NN denotes lymphomas
T12571 33609-33613 VB denotes were
T12572 33614-33623 RB denotes similarly
T12573 33624-33635 JJ denotes susceptible
T12574 33636-33638 TO denotes to
T12575 33639-33650 NN denotes triciribine
T12576 33650-33651 -COMMA- denotes ,
T12577 33652-33662 NN denotes BAY11–7085
T12578 33662-33663 -COMMA- denotes ,
T12579 33664-33667 CC denotes and
T12580 33668-33680 NN denotes cucurbitacin
T12581 33681-33682 CD denotes I
T12582 33683-33693 NN denotes treatments
T12583 33693-33694 -COMMA- denotes ,
T12584 33695-33698 CC denotes but
T12585 33699-33702 RB denotes not
T12586 33703-33711 NN denotes SB202190
T12587 33711-33712 -COMMA- denotes ,
T12588 33713-33718 NN denotes AG490
T12589 33718-33719 -COMMA- denotes ,
T12590 33720-33722 CC denotes or
T12591 33723-33728 NN denotes U0126
T12592 33729-33738 NN denotes treatment
T12593 33738-33739 -COMMA- denotes ,
T12594 33740-33750 VB denotes suggesting
T12595 33751-33755 IN denotes that
T12596 33756-33766 NN denotes activation
T12597 33767-33769 IN denotes of
T12598 33770-33773 NN denotes Akt
T12599 33773-33774 -COMMA- denotes ,
T12600 33775-33779 NN denotes NFκB
T12601 33779-33780 -COMMA- denotes ,
T12602 33781-33784 CC denotes and
T12603 33785-33790 NN denotes Stat3
T12604 33791-33794 CC denotes but
T12605 33795-33798 RB denotes not
T12606 33799-33803 NN denotes MAPK
T12607 33804-33812 NN denotes pathways
T12608 33813-33816 VB denotes are
T12609 33817-33832 NN denotes characteristics
T12610 33833-33843 VB denotes associated
T12611 33844-33848 IN denotes with
T12612 33849-33858 JJ denotes malignant
T12613 33859-33873 NN denotes transformation
T12614 33874-33875 -LRB- denotes (
T12615 33875-33881 NN denotes Figure
T12616 33882-33883 CD denotes 7
T12617 33883-33884 -RRB- denotes )
T12618 33884-33893 NN denotes . rapamyc
T12619 33893-33894 -COMMA- denotes i
T12620 33894-33896 DT denotes n,
T12621 33897-33906 NN denotes an inhibi
T12622 33906-33908 IN denotes to
T12623 33908-33912 NN denotes r of
T12624 33913-33914 -COMMA- denotes m
T12625 33914-33917 VB denotes TOR
T12626 33917-33920 RB denotes , d
T12627 33920-33926 VB denotes id not
T12628 33927-33930 DT denotes aff
T12629 33930-33939 NN denotes ect the v
T12630 33939-33941 IN denotes ia
T12631 33941-33944 DT denotes bil
T12632 33944-33954 JJ denotes ity of the
T12633 33955-33966 NN denotes transgenic
T12634 33966-33968 CC denotes ly
T12635 33968-33976 NN denotes mphocyte
T12636 33976-33981 NN denotes s or
T12637 33981-33982 -COMMA- denotes l
T12638 33982-33992 VB denotes ymphoma ce
T12639 33992-33996 IN denotes lls,
T12640 33997-34001 NN denotes conf
T12641 34001-34003 VB denotes ir
T12642 34003-34006 RB denotes min
T12643 34006-34014 VB denotes g that m
T12644 34014-34016 IN denotes TO
T12645 34016-34019 NN denotes R i
T12646 34019-34029 NN denotes s not targ
T12647 34029-34031 IN denotes et
T12648 34031-34035 NN denotes ed b
T12649 34035-34045 JJ denotes y Akt acti
T12650 34045-34056 NN denotes vation in L
T12651 34056-34058 CC denotes MP
T12652 34058-34067 JJ denotes 1 transge
T12653 34067-34075 NN denotes nic lymp
T12654 34075-34080 NN denotes hocyt
T12655 34080-34081 -LRB- denotes e
T12656 34081-34087 NN denotes s or m
T12657 34087-34088 CD denotes a
T12658 34088-34089 -RRB- denotes l
T14617 34135-34139 DT denotes This
T14618 34140-34145 NN denotes study
T14619 34146-34153 VB denotes defines
T14620 34154-34157 DT denotes the
T14621 34158-34167 JJ denotes oncogenic
T14622 34168-34178 NN denotes properties
T14623 34179-34181 IN denotes of
T14624 34182-34186 NN denotes LMP1
T14625 34187-34189 IN denotes in
T14626 34190-34199 VB denotes promoting
T14627 34200-34201 NN denotes B
T14628 34202-34206 NN denotes cell
T14629 34207-34222 NN denotes lymphomagenesis
T14630 34224-34228 NN denotes LMP1
T14631 34229-34239 JJ denotes transgenic
T14632 34240-34244 NN denotes mice
T14633 34245-34249 VB denotes have
T14634 34250-34251 DT denotes a
T14635 34252-34258 JJ denotes higher
T14636 34259-34268 NN denotes incidence
T14637 34269-34271 IN denotes of
T14638 34272-34280 NN denotes lymphoma
T14639 34281-34282 -LRB- denotes [
T14640 34282-34284 CD denotes 26
T14641 34284-34285 -RRB- denotes ]
T14642 34286-34289 CC denotes and
T14643 34290-34293 DT denotes the
T14644 34294-34305 NN denotes progression
T14645 34306-34308 TO denotes to
T14646 34309-34317 NN denotes lymphoma
T14647 34318-34328 VB denotes correlates
T14648 34329-34333 IN denotes with
T14649 34334-34340 JJ denotes higher
T14650 34341-34351 NN denotes expression
T14651 34352-34358 NN denotes levels
T14652 34359-34361 IN denotes of
T14653 34362-34366 NN denotes LMP1
T14654 34367-34368 -LRB- denotes (
T14655 34368-34374 NN denotes Figure
T14656 34375-34377 NN denotes 1A
T14657 34378-34381 CC denotes and
T14658 34382-34384 NN denotes 1B
T14659 34384-34385 -RRB- denotes )
T14660 34385-34386 -COMMA- denotes ,
T14661 34387-34397 VB denotes suggesting
T14662 34398-34402 IN denotes that
T14663 34403-34407 NN denotes LMP1
T14664 34408-34410 VB denotes is
T14665 34411-34419 RB denotes directly
T14666 34420-34428 VB denotes involved
T14667 34429-34431 IN denotes in
T14668 34432-34437 NN denotes tumor
T14669 34438-34449 NN denotes development
T14670 34451-34456 JJ denotes Table
T14671 34457-34458 CD denotes 1
T14672 34459-34469 VB denotes summarizes
T14673 34470-34473 DT denotes the
T14674 34474-34484 JJ denotes biological
T14675 34485-34488 CC denotes and
T14676 34489-34498 JJ denotes molecular
T14677 34499-34509 NN denotes properties
T14678 34510-34514 WDT denotes that
T14679 34515-34519 VB denotes were
T14680 34520-34530 VB denotes identified
T14681 34531-34533 IN denotes in
T14682 34534-34543 JJ denotes wild-type
T14683 34544-34547 CC denotes and
T14684 34548-34552 NN denotes LMP1
T14685 34553-34563 JJ denotes transgenic
T14686 34564-34573 NN denotes lymphomas
T14687 34575-34583 IN denotes Although
T14688 34584-34588 JJ denotes many
T14689 34589-34591 IN denotes of
T14690 34592-34595 DT denotes the
T14691 34596-34605 JJ denotes molecular
T14692 34606-34616 NN denotes properties
T14693 34617-34624 VB denotes studied
T14694 34625-34629 VB denotes were
T14695 34630-34637 JJ denotes similar
T14696 34638-34645 IN denotes between
T14697 34646-34655 JJ denotes wild-type
T14698 34656-34659 CC denotes and
T14699 34660-34664 NN denotes LMP1
T14700 34665-34675 JJ denotes transgenic
T14701 34676-34685 NN denotes lymphomas
T14702 34685-34686 -COMMA- denotes ,
T14703 34687-34692 EX denotes there
T14704 34693-34697 VB denotes were
T14705 34698-34712 VB denotes distinguishing
T14706 34713-34723 JJ denotes biological
T14707 34724-34734 NN denotes properties
T14708 34734-34735 -COMMA- denotes ,
T14709 34736-34742 RB denotes namely
T14710 34743-34746 DT denotes the
T14711 34747-34754 NN denotes ability
T14712 34755-34757 IN denotes of
T14713 34758-34762 NN denotes LMP1
T14714 34763-34773 JJ denotes transgenic
T14715 34774-34783 NN denotes lymphomas
T14716 34784-34786 TO denotes to
T14717 34787-34793 VB denotes induce
T14718 34794-34800 JJ denotes higher
T14719 34801-34807 NN denotes levels
T14720 34808-34810 IN denotes of
T14721 34811-34819 NN denotes survival
T14722 34820-34823 CC denotes and
T14723 34824-34837 NN denotes proliferation
T14724 34839-34852 RB denotes Interestingly
T14725 34852-34853 -COMMA- denotes ,
T14726 34854-34862 IN denotes although
T14727 34863-34867 NN denotes LMP1
T14728 34868-34878 JJ denotes transgenic
T14729 34879-34883 NN denotes mice
T14730 34884-34891 VB denotes develop
T14731 34892-34901 NN denotes lymphomas
T14732 34902-34904 IN denotes in
T14733 34905-34908 DT denotes the
T14734 34909-34913 JJ denotes same
T14735 34914-34918 NN denotes B-1a
T14736 34919-34923 NN denotes cell
T14737 34924-34928 NN denotes type
T14738 34929-34931 IN denotes as
T14739 34932-34943 JJ denotes spontaneous
T14740 34944-34953 JJ denotes wild-type
T14741 34954-34963 NN denotes lymphomas
T14742 34964-34965 -LRB- denotes (
T14743 34965-34971 NN denotes Figure
T14744 34972-34973 CD denotes 2
T14745 34973-34974 -RRB- denotes )
T14746 34974-34975 -COMMA- denotes ,
T14747 34976-34980 DT denotes some
T14748 34981-34990 NN denotes signaling
T14749 34991-34998 NN denotes effects
T14750 34999-35006 VB denotes induced
T14751 35007-35009 IN denotes by
T14752 35010-35014 NN denotes LMP1
T14753 35015-35018 MD denotes may
T14754 35019-35026 VB denotes explain
T14755 35027-35030 DT denotes the
T14756 35031-35039 VB denotes enhanced
T14757 35040-35049 NN denotes promotion
T14758 35050-35052 TO denotes to
T14759 35053-35068 NN denotes lymphomagenesis
T14760 35070-35075 IN denotes Since
T14761 35076-35090 JJ denotes CD40-deficient
T14762 35091-35095 NN denotes mice
T14763 35096-35100 VB denotes have
T14764 35101-35110 VB denotes decreased
T14765 35111-35118 NN denotes numbers
T14766 35119-35121 IN denotes of
T14767 35122-35135 NN denotes IgMhighIgDlow
T14768 35136-35141 NN denotes cells
T14769 35141-35142 -COMMA- denotes ,
T14770 35143-35144 DT denotes a
T14771 35145-35154 NN denotes phenotype
T14772 35155-35165 VB denotes associated
T14773 35166-35170 IN denotes with
T14774 35171-35174 NN denotes B-1
T14775 35174-35175 -COMMA- denotes ,
T14776 35176-35184 JJ denotes marginal
T14777 35185-35189 NN denotes zone
T14778 35189-35190 -COMMA- denotes ,
T14779 35191-35194 CC denotes and
T14780 35195-35201 NN denotes memory
T14781 35202-35203 NN denotes B
T14782 35204-35209 NN denotes cells
T14783 35209-35210 -COMMA- denotes ,
T14784 35211-35214 DT denotes the
T14785 35215-35222 NN denotes mimicry
T14786 35223-35225 IN denotes of
T14787 35226-35230 NN denotes CD40
T14788 35231-35240 NN denotes signaling
T14789 35241-35243 IN denotes by
T14790 35244-35248 NN denotes LMP1
T14791 35249-35254 MD denotes could
T14792 35255-35263 RB denotes possibly
T14793 35264-35274 VB denotes contribute
T14794 35275-35277 TO denotes to
T14795 35278-35281 DT denotes the
T14796 35282-35291 NN denotes expansion
T14797 35292-35294 IN denotes of
T14798 35295-35298 NN denotes B-1
T14799 35299-35304 NN denotes cells
T14800 35305-35306 -LRB- denotes [
T14801 35306-35308 CD denotes 20
T14802 35308-35309 -RRB- denotes ]
T14803 35311-35313 PRP denotes It
T14804 35314-35316 VB denotes is
T14805 35317-35327 JJ denotes noteworthy
T14806 35328-35332 IN denotes that
T14807 35333-35343 NN denotes expression
T14808 35344-35346 IN denotes of
T14809 35347-35351 NN denotes LMP1
T14810 35352-35354 IN denotes in
T14811 35355-35365 JJ denotes transgenic
T14812 35366-35370 NN denotes mice
T14813 35371-35374 VB denotes has
T14814 35375-35379 VB denotes been
T14815 35380-35385 VB denotes shown
T14816 35386-35388 TO denotes to
T14817 35389-35396 VB denotes inhibit
T14818 35397-35400 DT denotes the
T14819 35401-35410 NN denotes formation
T14820 35411-35413 IN denotes of
T14821 35414-35417 NN denotes GCs
T14822 35418-35419 -LRB- denotes [
T14823 35419-35424 CD denotes 23,49
T14824 35424-35425 -RRB- denotes ]
T14825 35425-35426 -COMMA- denotes ,
T14826 35427-35437 VB denotes preventing
T14827 35438-35445 JJ denotes typical
T14828 35446-35449 NN denotes B-2
T14829 35450-35455 NN denotes cells
T14830 35456-35460 IN denotes from
T14831 35461-35475 JJ denotes antigen-driven
T14832 35476-35485 NN denotes selection
T14833 35486-35489 CC denotes and
T14834 35490-35499 NN denotes expansion
T14835 35501-35504 DT denotes The
T14836 35505-35509 NN denotes lack
T14837 35510-35512 IN denotes of
T14838 35513-35515 NN denotes GC
T14839 35516-35525 NN denotes reactions
T14840 35526-35529 MD denotes may
T14841 35530-35540 VB denotes contribute
T14842 35541-35543 TO denotes to
T14843 35544-35547 DT denotes the
T14844 35548-35552 NN denotes bias
T14845 35553-35555 IN denotes of
T14846 35556-35560 NN denotes LMP1
T14847 35561-35571 JJ denotes transgenic
T14848 35572-35576 NN denotes mice
T14849 35577-35584 IN denotes towards
T14850 35585-35588 NN denotes B-1
T14851 35589-35593 NN denotes cell
T14852 35594-35603 NN denotes lymphomas
T14853 35605-35618 RB denotes Interestingly
T14854 35618-35619 -COMMA- denotes ,
T14855 35620-35624 NN denotes LMP2
T14856 35625-35634 NN denotes signaling
T14857 35635-35639 RB denotes also
T14858 35640-35646 VB denotes favors
T14859 35647-35658 NN denotes development
T14860 35659-35661 IN denotes of
T14861 35662-35665 NN denotes B-1
T14862 35666-35671 NN denotes cells
T14863 35671-35672 -COMMA- denotes ,
T14864 35673-35676 CC denotes but
T14865 35677-35681 DT denotes this
T14866 35682-35688 VB denotes occurs
T14867 35689-35691 IN denotes in
T14868 35692-35695 DT denotes the
T14869 35696-35703 NN denotes absence
T14870 35704-35706 IN denotes of
T14871 35707-35721 NN denotes transformation
T14872 35723-35728 DT denotes These
T14873 35729-35736 NN denotes results
T14874 35737-35744 VB denotes suggest
T14875 35745-35749 IN denotes that
T14876 35750-35753 DT denotes the
T14877 35754-35761 NN denotes mimicry
T14878 35762-35764 IN denotes of
T14879 35765-35766 NN denotes B
T14880 35767-35771 NN denotes cell
T14881 35772-35780 NN denotes receptor
T14882 35781-35790 NN denotes signaling
T14883 35791-35793 IN denotes by
T14884 35794-35798 NN denotes LMP2
T14885 35799-35807 VB denotes promotes
T14886 35808-35811 NN denotes B-1
T14887 35812-35816 NN denotes cell
T14888 35817-35832 NN denotes differentiation
T14889 35833-35836 CC denotes but
T14890 35837-35840 RB denotes not
T14891 35841-35855 NN denotes transformation
T14892 35856-35857 -LRB- denotes [
T14893 35857-35865 CD denotes 24,50,51
T14894 35865-35866 -RRB- denotes ]
T14895 35868-35872 DT denotes This
T14896 35873-35882 NN denotes promotion
T14897 35883-35885 IN denotes of
T14898 35886-35889 NN denotes B-1
T14899 35890-35905 NN denotes differentiation
T14900 35906-35909 MD denotes may
T14901 35910-35917 VB denotes account
T14902 35918-35921 IN denotes for
T14903 35922-35925 DT denotes the
T14904 35926-35933 NN denotes ability
T14905 35934-35936 IN denotes of
T14906 35937-35941 NN denotes LMP2
T14907 35942-35944 TO denotes to
T14908 35945-35955 VB denotes exacerbate
T14909 35956-35968 NN denotes autoimmunity
T14910 35969-35972 CC denotes and
T14911 35973-35979 VB denotes bypass
T14912 35980-35986 NN denotes anergy
T14913 35987-35996 NN denotes induction
T14914 35997-35998 -LRB- denotes [
T14915 35998-36003 CD denotes 52,53
T14916 36003-36004 -RRB- denotes ]
T14917 36006-36008 IN denotes In
T14918 36009-36017 NN denotes contrast
T14919 36017-36018 -COMMA- denotes ,
T14920 36019-36022 DT denotes the
T14921 36023-36036 NN denotes preponderance
T14922 36037-36039 IN denotes of
T14923 36040-36046 NN denotes tumors
T14924 36047-36049 IN denotes of
T14925 36050-36054 NN denotes B-1a
T14926 36055-36061 NN denotes origin
T14927 36062-36066 VB denotes does
T14928 36067-36070 RB denotes not
T14929 36071-36078 VB denotes reflect
T14930 36079-36086 NN denotes effects
T14931 36087-36089 IN denotes of
T14932 36090-36094 NN denotes LMP1
T14933 36095-36104 NN denotes signaling
T14934 36105-36107 IN denotes on
T14935 36108-36109 NN denotes B
T14936 36110-36114 NN denotes cell
T14937 36115-36130 NN denotes differentiation
T14938 36130-36131 -COMMA- denotes ,
T14939 36132-36134 IN denotes as
T14940 36135-36142 JJ denotes splenic
T14941 36143-36144 NN denotes B
T14942 36145-36150 NN denotes cells
T14943 36151-36155 IN denotes from
T14944 36156-36163 JJ denotes healthy
T14945 36164-36168 NN denotes LMP1
T14946 36169-36179 JJ denotes transgenic
T14947 36180-36184 NN denotes mice
T14948 36185-36192 VB denotes contain
T14949 36193-36200 JJ denotes similar
T14950 36201-36208 NN denotes numbers
T14951 36209-36211 IN denotes of
T14952 36212-36215 NN denotes B-1
T14953 36216-36219 CC denotes and
T14954 36220-36223 NN denotes B-2
T14955 36224-36229 NN denotes cells
T14956 36230-36232 IN denotes as
T14957 36233-36242 JJ denotes wild-type
T14958 36243-36247 NN denotes mice
T14959 36249-36251 IN denotes In
T14960 36252-36259 NN denotes support
T14961 36260-36262 IN denotes of
T14962 36263-36267 DT denotes this
T14963 36268-36272 NN denotes lack
T14964 36273-36275 IN denotes of
T14965 36276-36282 NN denotes effect
T14966 36282-36283 -COMMA- denotes ,
T14967 36284-36287 DT denotes the
T14968 36288-36303 NN denotes differentiation
T14969 36304-36306 IN denotes of
T14970 36307-36310 NN denotes B-1
T14971 36311-36317 IN denotes versus
T14972 36318-36321 NN denotes B-2
T14973 36322-36327 NN denotes cells
T14974 36328-36330 VB denotes is
T14975 36331-36338 VB denotes thought
T14976 36339-36341 TO denotes to
T14977 36342-36344 VB denotes be
T14978 36345-36356 JJ denotes independent
T14979 36357-36359 IN denotes of
T14980 36360-36364 NN denotes CD40
T14981 36365-36374 NN denotes signaling
T14982 36375-36376 -LRB- denotes [
T14983 36376-36378 CD denotes 54
T14984 36378-36379 -RRB- denotes ]
T14985 36381-36384 NN denotes B-1
T14986 36385-36390 NN denotes cells
T14987 36391-36401 VB denotes constitute
T14988 36402-36405 DT denotes the
T14989 36406-36417 JJ denotes predominant
T14990 36418-36428 NN denotes lymphocyte
T14991 36429-36439 NN denotes population
T14992 36440-36442 IN denotes in
T14993 36443-36446 DT denotes the
T14994 36447-36457 JJ denotes peritoneal
T14995 36458-36461 CC denotes and
T14996 36462-36479 JJ denotes pleuropericardial
T14997 36480-36488 NN denotes cavities
T14998 36488-36489 -COMMA- denotes ,
T14999 36490-36495 IN denotes while
T15000 36496-36499 NN denotes B-2
T15001 36500-36505 NN denotes cells
T15002 36506-36509 VB denotes are
T15003 36510-36516 RB denotes mainly
T15004 36517-36522 VB denotes found
T15005 36523-36525 IN denotes in
T15006 36526-36529 DT denotes the
T15007 36530-36536 NN denotes spleen
T15008 36536-36537 -COMMA- denotes ,
T15009 36538-36543 NN denotes lymph
T15010 36544-36548 NN denotes node
T15011 36548-36549 -COMMA- denotes ,
T15012 36550-36553 CC denotes and
T15013 36554-36564 JJ denotes peripheral
T15014 36565-36570 NN denotes blood
T15015 36572-36575 NN denotes B-1
T15016 36576-36581 NN denotes cells
T15017 36582-36589 VB denotes produce
T15018 36590-36593 DT denotes the
T15019 36594-36598 JJ denotes main
T15020 36599-36605 NN denotes source
T15021 36606-36608 IN denotes of
T15022 36609-36612 NN denotes IgM
T15023 36613-36616 CC denotes and
T15024 36617-36620 NN denotes IgA
T15025 36621-36631 NN denotes antibodies
T15026 36632-36634 IN denotes in
T15027 36635-36640 NN denotes serum
T15028 36640-36641 -COMMA- denotes ,
T15029 36642-36647 WDT denotes which
T15030 36648-36651 VB denotes are
T15031 36652-36660 VB denotes involved
T15032 36661-36663 IN denotes in
T15033 36664-36665 NN denotes T
T15034 36666-36682 JJ denotes cell–independent
T15035 36683-36692 NN denotes responses
T15036 36693-36695 TO denotes to
T15037 36696-36702 JJ denotes common
T15038 36703-36712 JJ denotes microbial
T15039 36713-36721 NN denotes antigens
T15040 36723-36734 RB denotes Importantly
T15041 36734-36735 -COMMA- denotes ,
T15042 36736-36739 NN denotes B-1
T15043 36740-36745 NN denotes cells
T15044 36746-36750 VB denotes have
T15045 36751-36754 DT denotes the
T15046 36755-36761 JJ denotes unique
T15047 36762-36770 NN denotes capacity
T15048 36771-36773 TO denotes to
T15049 36774-36778 PRP denotes self
T15050 36779-36788 VB denotes replenish
T15051 36789-36792 CC denotes and
T15052 36793-36796 VB denotes are
T15053 36797-36801 RB denotes also
T15054 36802-36813 VB denotes predisposed
T15055 36814-36816 TO denotes to
T15056 36817-36831 NN denotes transformation
T15057 36832-36833 -LRB- denotes [
T15058 36833-36838 CD denotes 28,29
T15059 36838-36839 -RRB- denotes ]
T15060 36841-36847 JJ denotes Clonal
T15061 36848-36857 NN denotes expansion
T15062 36858-36860 IN denotes of
T15063 36861-36864 NN denotes B-1
T15064 36865-36870 NN denotes cells
T15065 36871-36874 MD denotes can
T15066 36875-36877 VB denotes be
T15067 36878-36886 VB denotes detected
T15068 36887-36889 IN denotes in
T15069 36890-36895 VB denotes aging
T15070 36896-36900 NN denotes mice
T15071 36901-36906 IN denotes above
T15072 36907-36909 CD denotes 18
T15073 36910-36912 NN denotes mo
T15074 36913-36915 IN denotes of
T15075 36916-36919 NN denotes age
T15076 36919-36920 -COMMA- denotes ,
T15077 36921-36924 CC denotes and
T15078 36925-36928 NN denotes B-1
T15079 36929-36934 NN denotes cells
T15080 36935-36938 VB denotes are
T15081 36939-36946 VB denotes thought
T15082 36947-36949 TO denotes to
T15083 36950-36952 VB denotes be
T15084 36953-36956 DT denotes the
T15085 36957-36963 JJ denotes murine
T15086 36964-36974 NN denotes progenitor
T15087 36975-36977 IN denotes of
T15088 36978-36979 NN denotes B
T15089 36980-36984 NN denotes cell
T15090 36985-36992 JJ denotes chronic
T15091 36993-37004 JJ denotes lymphocytic
T15092 37005-37013 NN denotes leukemia
T15093 37014-37015 -LRB- denotes [
T15094 37015-37017 CD denotes 30
T15095 37017-37018 -RRB- denotes ]
T15096 37020-37023 DT denotes The
T15097 37024-37028 NN denotes data
T15098 37029-37038 VB denotes presented
T15099 37039-37041 IN denotes in
T15100 37042-37046 DT denotes this
T15101 37047-37052 NN denotes study
T15102 37053-37061 VB denotes indicate
T15103 37062-37066 IN denotes that
T15104 37067-37075 IN denotes although
T15105 37076-37080 NN denotes LMP1
T15106 37081-37083 VB denotes is
T15107 37084-37093 VB denotes expressed
T15108 37094-37096 IN denotes in
T15109 37097-37100 DT denotes all
T15110 37101-37102 NN denotes B
T15111 37103-37114 NN denotes lymphocytes
T15112 37115-37117 IN denotes in
T15113 37118-37121 DT denotes the
T15114 37122-37132 JJ denotes transgenic
T15115 37133-37137 NN denotes mice
T15116 37137-37138 -COMMA- denotes ,
T15117 37139-37149 NN denotes malignancy
T15118 37150-37158 VB denotes develops
T15119 37159-37161 IN denotes in
T15120 37162-37166 DT denotes this
T15121 37167-37175 JJ denotes specific
T15122 37176-37182 NN denotes subset
T15123 37183-37185 IN denotes of
T15124 37186-37187 NN denotes B
T15125 37188-37193 NN denotes cells
T15126 37195-37198 DT denotes The
T15127 37199-37207 VB denotes elevated
T15128 37208-37218 NN denotes expression
T15129 37219-37221 IN denotes of
T15130 37222-37226 NN denotes LMP1
T15131 37227-37229 IN denotes in
T15132 37230-37234 NN denotes B-1a
T15133 37235-37240 NN denotes cells
T15134 37241-37244 CC denotes and
T15135 37245-37248 DT denotes the
T15136 37249-37259 NN denotes activation
T15137 37260-37262 IN denotes of
T15138 37263-37271 JJ denotes specific
T15139 37272-37280 NN denotes pathways
T15140 37281-37291 RB denotes apparently
T15141 37292-37298 VB denotes induce
T15142 37299-37308 JJ denotes malignant
T15143 37309-37315 NN denotes growth
T15144 37317-37322 DT denotes These
T15145 37323-37327 JJ denotes same
T15146 37328-37336 NN denotes pathways
T15147 37337-37340 MD denotes can
T15148 37341-37345 RB denotes also
T15149 37346-37352 VB denotes become
T15150 37353-37365 RB denotes sporadically
T15151 37366-37375 VB denotes activated
T15152 37376-37378 IN denotes in
T15153 37379-37383 JJ denotes aged
T15154 37384-37388 NN denotes mice
T15155 37389-37392 CC denotes and
T15156 37393-37397 RB denotes also
T15157 37398-37404 VB denotes result
T15158 37405-37407 IN denotes in
T15159 37408-37416 NN denotes lymphoma
T15160 37417-37428 NN denotes development
T15161 37430-37434 DT denotes This
T15162 37435-37437 VB denotes is
T15163 37438-37445 JJ denotes similar
T15164 37446-37448 TO denotes to
T15165 37449-37463 JJ denotes EBV-associated
T15166 37464-37471 NN denotes cancers
T15167 37472-37474 FW denotes in
T15168 37475-37479 FW denotes vivo
T15169 37479-37480 -COMMA- denotes ,
T15170 37481-37486 WRB denotes where
T15171 37487-37495 NN denotes pathways
T15172 37496-37500 WDT denotes that
T15173 37501-37504 VB denotes are
T15174 37505-37514 VB denotes activated
T15175 37515-37517 IN denotes by
T15176 37518-37522 NN denotes LMP1
T15177 37523-37526 VB denotes are
T15178 37527-37531 RB denotes also
T15179 37532-37541 VB denotes activated
T15180 37542-37544 IN denotes in
T15181 37545-37548 DT denotes the
T15182 37549-37553 RB denotes less
T15183 37554-37563 JJ denotes prevalent
T15184 37564-37576 JJ denotes EBV-negative
T15185 37577-37582 NN denotes forms
T15186 37583-37585 IN denotes of
T15187 37586-37589 DT denotes the
T15188 37590-37597 NN denotes cancers
T15189 37598-37599 -LRB- denotes [
T15190 37599-37607 CD denotes 40,55–58
T15191 37607-37608 -RRB- denotes ]
T15192 37610-37614 RB denotes Thus
T15193 37614-37615 -COMMA- denotes ,
T15194 37616-37619 DT denotes the
T15195 37620-37632 NN denotes contribution
T15196 37633-37635 IN denotes of
T15197 37636-37639 NN denotes EBV
T15198 37640-37643 CC denotes and
T15199 37644-37648 NN denotes LMP1
T15200 37649-37651 TO denotes to
T15201 37652-37657 NN denotes tumor
T15202 37658-37669 NN denotes development
T15203 37670-37672 VB denotes is
T15204 37673-37683 RB denotes apparently
T15205 37684-37687 DT denotes the
T15206 37688-37698 JJ denotes continuous
T15207 37699-37709 NN denotes activation
T15208 37710-37712 IN denotes of
T15209 37713-37721 NN denotes pathways
T15210 37722-37726 WDT denotes that
T15211 37727-37730 MD denotes can
T15212 37731-37735 RB denotes also
T15213 37736-37738 VB denotes be
T15214 37739-37751 RB denotes sporadically
T15215 37752-37761 VB denotes activated
T15216 37762-37765 CC denotes and
T15217 37766-37776 VB denotes contribute
T15218 37777-37779 TO denotes to
T15219 37780-37785 NN denotes tumor
T15220 37786-37797 NN denotes development
T15221 37799-37802 DT denotes The
T15222 37803-37812 NN denotes lymphomas
T15223 37813-37817 VB denotes were
T15224 37818-37824 VB denotes marked
T15225 37825-37827 IN denotes by
T15226 37828-37831 DT denotes the
T15227 37832-37844 NN denotes upregulation
T15228 37845-37847 IN denotes of
T15229 37848-37852 NN denotes IL10
T15230 37852-37853 -COMMA- denotes ,
T15231 37854-37866 JJ denotes constitutive
T15232 37867-37877 NN denotes activation
T15233 37878-37880 IN denotes of
T15234 37881-37886 NN denotes Stat3
T15235 37887-37896 NN denotes signaling
T15236 37896-37897 -COMMA- denotes ,
T15237 37898-37901 CC denotes and
T15238 37902-37903 DT denotes a
T15239 37904-37915 NN denotes requirement
T15240 37916-37919 IN denotes for
T15241 37920-37930 NN denotes activation
T15242 37931-37933 IN denotes of
T15243 37934-37937 NN denotes Akt
T15244 37937-37938 -COMMA- denotes ,
T15245 37939-37943 NN denotes NFκB
T15246 37943-37944 -COMMA- denotes ,
T15247 37945-37948 CC denotes and
T15248 37949-37954 NN denotes Stat3
T15249 37955-37963 NN denotes pathways
T15250 37964-37965 -LRB- denotes (
T15251 37965-37972 NN denotes Figures
T15252 37973-37974 CD denotes 5
T15253 37975-37978 CC denotes and
T15254 37979-37980 CD denotes 7
T15255 37980-37981 -RRB- denotes )
T15256 37983-37992 NN denotes Induction
T15257 37993-37995 IN denotes of
T15258 37996-38000 NN denotes IL10
T15259 38001-38003 VB denotes is
T15260 38004-38014 VB denotes associated
T15261 38015-38019 IN denotes with
T15262 38020-38023 DT denotes the
T15263 38024-38038 NN denotes transformation
T15264 38039-38041 IN denotes of
T15265 38042-38045 NN denotes B-1
T15266 38046-38055 NN denotes lymphomas
T15267 38056-38058 IN denotes in
T15268 38059-38063 NN denotes mice
T15269 38064-38065 -LRB- denotes [
T15270 38065-38070 CD denotes 59,60
T15271 38070-38071 -RRB- denotes ]
T15272 38072-38075 CC denotes and
T15273 38076-38078 VB denotes is
T15274 38079-38089 RB denotes frequently
T15275 38090-38100 VB denotes associated
T15276 38101-38105 IN denotes with
T15277 38106-38118 JJ denotes EBV-positive
T15278 38119-38120 NN denotes B
T15279 38121-38125 NN denotes cell
T15280 38126-38138 NN denotes malignancies
T15281 38139-38145 VB denotes acting
T15282 38146-38148 IN denotes as
T15283 38149-38150 DT denotes a
T15284 38151-38152 NN denotes B
T15285 38153-38157 NN denotes cell
T15286 38158-38164 NN denotes growth
T15287 38165-38171 NN denotes factor
T15288 38172-38173 -LRB- denotes [
T15289 38173-38178 CD denotes 35–38
T15290 38178-38179 -RRB- denotes ]
T15291 38181-38183 IN denotes In
T15292 38184-38192 NN denotes addition
T15293 38192-38193 -COMMA- denotes ,
T15294 38194-38198 NN denotes LMP1
T15295 38199-38202 VB denotes has
T15296 38203-38207 VB denotes been
T15297 38208-38213 VB denotes shown
T15298 38214-38216 TO denotes to
T15299 38217-38226 VB denotes stimulate
T15300 38227-38231 NN denotes IL10
T15301 38232-38242 NN denotes expression
T15302 38243-38245 IN denotes in
T15303 38246-38253 NN denotes Burkitt
T15304 38254-38262 NN denotes lymphoma
T15305 38263-38267 NN denotes cell
T15306 38268-38273 NN denotes lines
T15307 38274-38275 -LRB- denotes [
T15308 38275-38280 CD denotes 61,62
T15309 38280-38281 -RRB- denotes ]
T15310 38283-38287 DT denotes This
T15311 38288-38296 VB denotes suggests
T15312 38297-38301 IN denotes that
T15313 38302-38310 IN denotes although
T15314 38311-38316 NN denotes Stat3
T15315 38317-38319 VB denotes is
T15316 38320-38334 RB denotes constitutively
T15317 38335-38344 VB denotes activated
T15318 38345-38347 IN denotes in
T15319 38348-38351 DT denotes the
T15320 38352-38360 NN denotes lymphoma
T15321 38361-38366 NN denotes cells
T15322 38366-38367 -COMMA- denotes ,
T15323 38368-38371 DT denotes the
T15324 38372-38381 NN denotes induction
T15325 38382-38384 IN denotes of
T15326 38385-38389 NN denotes IL10
T15327 38390-38393 MD denotes may
T15328 38394-38401 RB denotes further
T15329 38402-38409 VB denotes enhance
T15330 38410-38415 NN denotes Stat3
T15331 38416-38426 NN denotes activation
T15332 38427-38429 CC denotes or
T15333 38430-38433 MD denotes may
T15334 38434-38444 VB denotes contribute
T15335 38445-38447 TO denotes to
T15336 38448-38453 JJ denotes other
T15337 38454-38469 JJ denotes IL10-responsive
T15338 38470-38479 NN denotes signaling
T15339 38480-38488 NN denotes pathways
T15340 38490-38494 NN denotes LMP1
T15341 38495-38504 VB denotes activates
T15342 38505-38509 CC denotes both
T15343 38510-38513 DT denotes the
T15344 38514-38523 JJ denotes canonical
T15345 38524-38527 CC denotes and
T15346 38528-38541 JJ denotes non-canonical
T15347 38542-38550 NN denotes pathways
T15348 38551-38553 IN denotes of
T15349 38554-38558 NN denotes NFκB
T15350 38559-38568 NN denotes signaling
T15351 38569-38570 -LRB- denotes [
T15352 38570-38578 CD denotes 14,63–65
T15353 38578-38579 -RRB- denotes ]
T15354 38579-38580 -COMMA- denotes ,
T15355 38581-38584 CC denotes and
T15356 38585-38595 NN denotes inhibition
T15357 38596-38598 IN denotes of
T15358 38599-38603 NN denotes NFκB
T15359 38604-38611 VB denotes blocked
T15360 38612-38615 DT denotes the
T15361 38616-38624 NN denotes survival
T15362 38625-38627 IN denotes of
T15363 38628-38632 NN denotes LMP1
T15364 38633-38643 JJ denotes transgenic
T15365 38644-38655 NN denotes lymphocytes
T15366 38656-38659 CC denotes and
T15367 38660-38673 JJ denotes LMP1-positive
T15368 38674-38677 CC denotes and
T15369 38678-38687 JJ denotes -negative
T15370 38688-38696 NN denotes lymphoma
T15371 38697-38702 NN denotes cells
T15372 38704-38708 NN denotes NFκB
T15373 38709-38712 CC denotes and
T15374 38713-38717 NN denotes PI3K
T15375 38718-38727 NN denotes signaling
T15376 38728-38731 VB denotes are
T15377 38732-38739 JJ denotes crucial
T15378 38740-38743 IN denotes for
T15379 38744-38756 JJ denotes CD40-induced
T15380 38757-38770 NN denotes proliferation
T15381 38770-38771 -COMMA- denotes ,
T15382 38772-38775 CC denotes and
T15383 38776-38780 NN denotes mice
T15384 38781-38790 JJ denotes deficient
T15385 38791-38794 IN denotes for
T15386 38795-38799 NN denotes cRel
T15387 38800-38802 CC denotes or
T15388 38803-38806 DT denotes the
T15389 38807-38810 NN denotes p85
T15390 38811-38821 JJ denotes regulatory
T15391 38822-38829 NN denotes subunit
T15392 38830-38832 IN denotes of
T15393 38833-38837 NN denotes PI3K
T15394 38838-38841 VB denotes are
T15395 38842-38854 JJ denotes unresponsive
T15396 38855-38857 TO denotes to
T15397 38858-38867 JJ denotes mitogenic
T15398 38868-38875 NN denotes stimuli
T15399 38875-38876 -COMMA- denotes ,
T15400 38877-38886 VB denotes including
T15401 38887-38891 NN denotes CD40
T15402 38892-38900 NN denotes ligation
T15403 38901-38902 -LRB- denotes [
T15404 38902-38907 CD denotes 66–68
T15405 38907-38908 -RRB- denotes ]
T15406 38910-38912 PRP denotes We
T15407 38913-38917 VB denotes have
T15408 38918-38928 RB denotes previously
T15409 38929-38934 VB denotes shown
T15410 38935-38939 IN denotes that
T15411 38940-38944 NN denotes cRel
T15412 38945-38947 VB denotes is
T15413 38948-38960 RB denotes specifically
T15414 38961-38970 VB denotes activated
T15415 38971-38973 IN denotes in
T15416 38974-38978 CC denotes both
T15417 38979-38988 JJ denotes wild-type
T15418 38989-38992 CC denotes and
T15419 38993-38997 NN denotes LMP1
T15420 38998-39008 JJ denotes transgenic
T15421 39009-39018 NN denotes lymphomas
T15422 39018-39019 -COMMA- denotes ,
T15423 39020-39030 VB denotes suggesting
T15424 39031-39035 IN denotes that
T15425 39036-39046 NN denotes activation
T15426 39047-39049 IN denotes of
T15427 39050-39054 NN denotes cRel
T15428 39055-39057 VB denotes is
T15429 39058-39068 VB denotes associated
T15430 39069-39073 IN denotes with
T15431 39074-39075 NN denotes B
T15432 39076-39080 NN denotes cell
T15433 39081-39095 NN denotes transformation
T15434 39096-39097 -LRB- denotes [
T15435 39097-39099 CD denotes 27
T15436 39099-39100 -RRB- denotes ]
T15437 39102-39105 PRP-DOLLAR- denotes Our
T15438 39106-39118 NN denotes observations
T15439 39119-39126 VB denotes suggest
T15440 39127-39131 IN denotes that
T15441 39132-39139 JJ denotes similar
T15442 39140-39142 TO denotes to
T15443 39143-39155 JJ denotes CD40-induced
T15444 39156-39169 NN denotes proliferation
T15445 39169-39170 -COMMA- denotes ,
T15446 39171-39175 NN denotes LMP1
T15447 39176-39183 VB denotes induces
T15448 39184-39197 NN denotes proliferation
T15449 39198-39205 IN denotes through
T15450 39206-39219 JJ denotes PI3K-mediated
T15451 39220-39230 NN denotes activation
T15452 39231-39233 IN denotes of
T15453 39234-39237 NN denotes Akt
T15454 39238-39241 CC denotes and
T15455 39242-39252 NN denotes activation
T15456 39253-39255 IN denotes of
T15457 39256-39260 NN denotes NFκB
T15458 39261-39271 NN denotes components
T15459 39272-39276 JJ denotes such
T15460 39277-39279 IN denotes as
T15461 39280-39284 NN denotes cRel
T15462 39286-39290 NN denotes CD40
T15463 39291-39295 RB denotes also
T15464 39296-39303 VB denotes induces
T15465 39304-39318 NN denotes downregulation
T15466 39319-39321 IN denotes of
T15467 39322-39325 DT denotes the
T15468 39326-39330 NN denotes cell
T15469 39331-39336 NN denotes cycle
T15470 39337-39346 NN denotes inhibitor
T15471 39347-39350 NN denotes p27
T15472 39351-39358 IN denotes through
T15473 39359-39360 DT denotes a
T15474 39361-39375 JJ denotes PI3K-dependent
T15475 39376-39382 NN denotes manner
T15476 39382-39383 -COMMA- denotes ,
T15477 39384-39387 CC denotes and
T15478 39388-39391 DT denotes the
T15479 39392-39396 NN denotes LMP1
T15480 39397-39405 NN denotes lymphoma
T15481 39406-39411 NN denotes cells
T15482 39412-39416 RB denotes also
T15483 39417-39420 VB denotes had
T15484 39421-39430 VB denotes decreased
T15485 39431-39437 NN denotes levels
T15486 39438-39440 IN denotes of
T15487 39441-39444 NN denotes p27
T15488 39445-39449 IN denotes with
T15489 39450-39465 NN denotes phosphorylation
T15490 39466-39468 IN denotes of
T15491 39469-39471 NN denotes Rb
T15492 39472-39475 CC denotes and
T15493 39476-39485 VB denotes increased
T15494 39486-39490 NN denotes Cdk2
T15495 39491-39492 -LRB- denotes (
T15496 39492-39498 NN denotes Figure
T15497 39499-39501 NN denotes 6C
T15498 39501-39502 -RRB- denotes )
T15499 39503-39504 -LRB- denotes [
T15500 39504-39506 CD denotes 66
T15501 39506-39507 -RRB- denotes ]
T15502 39509-39517 IN denotes Although
T15503 39518-39522 NN denotes LMP1
T15504 39523-39526 VB denotes has
T15505 39527-39531 VB denotes been
T15506 39532-39537 VB denotes shown
T15507 39538-39540 TO denotes to
T15508 39541-39551 VB denotes deregulate
T15509 39552-39555 DT denotes the
T15510 39556-39558 NN denotes Rb
T15511 39559-39566 NN denotes pathway
T15512 39567-39569 IN denotes in
T15513 39570-39580 JJ denotes epithelial
T15514 39581-39586 NN denotes cells
T15515 39587-39588 -LRB- denotes [
T15516 39588-39590 CD denotes 69
T15517 39590-39591 -RRB- denotes ]
T15518 39591-39592 -COMMA- denotes ,
T15519 39593-39595 TO denotes to
T15520 39596-39599 PRP-DOLLAR- denotes our
T15521 39600-39609 NN denotes knowledge
T15522 39610-39614 DT denotes this
T15523 39615-39617 VB denotes is
T15524 39618-39621 DT denotes the
T15525 39622-39627 JJ denotes first
T15526 39628-39641 NN denotes demonstration
T15527 39642-39644 IN denotes of
T15528 39645-39649 DT denotes this
T15529 39650-39658 NN denotes property
T15530 39659-39661 IN denotes in
T15531 39662-39663 NN denotes B
T15532 39664-39675 NN denotes lymphocytes
T15533 39677-39680 DT denotes The
T15534 39681-39692 NN denotes requirement
T15535 39693-39696 IN denotes for
T15536 39697-39700 NN denotes Akt
T15537 39701-39711 NN denotes activation
T15538 39712-39715 VB denotes was
T15539 39716-39725 VB denotes confirmed
T15540 39726-39728 IN denotes by
T15541 39729-39732 DT denotes the
T15542 39733-39741 JJ denotes striking
T15543 39742-39752 NN denotes inhibition
T15544 39753-39755 IN denotes of
T15545 39756-39764 NN denotes lymphoma
T15546 39765-39774 NN denotes viability
T15547 39775-39777 IN denotes by
T15548 39778-39789 NN denotes triciribine
T15549 39789-39790 -COMMA- denotes ,
T15550 39791-39793 DT denotes an
T15551 39794-39797 NN denotes Akt
T15552 39798-39807 NN denotes inhibitor
T15553 39809-39816 RB denotes However
T15554 39816-39817 -COMMA- denotes ,
T15555 39818-39821 DT denotes the
T15556 39822-39831 VB denotes activated
T15557 39832-39836 NN denotes pAkt
T15558 39837-39840 VB denotes did
T15559 39841-39844 RB denotes not
T15560 39845-39849 VB denotes lead
T15561 39850-39852 TO denotes to
T15562 39853-39868 NN denotes phosphorylation
T15563 39869-39872 CC denotes and
T15564 39873-39885 NN denotes inactivation
T15565 39886-39888 IN denotes of
T15566 39889-39892 DT denotes the
T15567 39893-39903 JJ denotes downstream
T15568 39904-39910 NN denotes target
T15569 39911-39915 NN denotes GSK3
T15570 39916-39917 -LRB- denotes (
T15571 39917-39923 NN denotes Figure
T15572 39924-39926 NN denotes 6A
T15573 39926-39927 -RRB- denotes )
T15574 39929-39933 DT denotes This
T15575 39934-39940 NN denotes effect
T15576 39941-39944 VB denotes has
T15577 39945-39949 RB denotes also
T15578 39950-39954 VB denotes been
T15579 39955-39964 VB denotes described
T15580 39965-39967 IN denotes in
T15581 39968-39980 JJ denotes EBV-positive
T15582 39981-39983 NN denotes HD
T15583 39984-39992 NN denotes biopsies
T15584 39993-39994 -LRB- denotes [
T15585 39994-39996 CD denotes 40
T15586 39996-39997 -RRB- denotes ]
T15587 39999-40001 IN denotes In
T15588 40002-40010 NN denotes contrast
T15589 40010-40011 -COMMA- denotes ,
T15590 40012-40021 NN denotes rapamycin
T15591 40021-40022 -COMMA- denotes ,
T15592 40023-40028 NN denotes U0126
T15593 40028-40029 -COMMA- denotes ,
T15594 40030-40033 CC denotes and
T15595 40034-40042 NN denotes SB202190
T15596 40043-40046 VB denotes did
T15597 40047-40050 RB denotes not
T15598 40051-40057 VB denotes affect
T15599 40058-40061 DT denotes the
T15600 40062-40070 NN denotes survival
T15601 40071-40073 IN denotes of
T15602 40074-40078 NN denotes LMP1
T15603 40079-40089 JJ denotes transgenic
T15604 40090-40101 NN denotes lymphocytes
T15605 40102-40104 CC denotes or
T15606 40105-40108 DT denotes the
T15607 40109-40118 JJ denotes wild-type
T15608 40119-40122 CC denotes and
T15609 40123-40127 NN denotes LMP1
T15610 40128-40138 JJ denotes transgenic
T15611 40139-40147 NN denotes lymphoma
T15612 40148-40153 NN denotes cells
T15613 40154-40155 -LRB- denotes (
T15614 40155-40161 NNP denotes Figure
T15615 40162-40164 NNP denotes 7A
T15616 40164-40165 -COMMA- denotes ,
T15617 40166-40168 NN denotes 7C
T15618 40168-40169 -COMMA- denotes ,
T15619 40170-40173 CC denotes and
T15620 40174-40176 NN denotes 7E
T15621 40176-40177 -RRB- denotes )
T15622 40179-40183 DT denotes This
T15623 40184-40188 NN denotes lack
T15624 40189-40191 IN denotes of
T15625 40192-40198 NN denotes effect
T15626 40199-40201 IN denotes by
T15627 40202-40211 NN denotes rapamycin
T15628 40212-40221 VB denotes confirmed
T15629 40222-40225 DT denotes the
T15630 40226-40233 NN denotes absence
T15631 40234-40236 IN denotes of
T15632 40237-40246 VB denotes activated
T15633 40247-40253 NN denotes p-mTOR
T15634 40254-40260 NN denotes levels
T15635 40261-40262 -LRB- denotes (
T15636 40262-40268 NN denotes Figure
T15637 40269-40271 NN denotes 6B
T15638 40271-40272 -RRB- denotes )
T15639 40274-40279 DT denotes These
T15640 40280-40288 NN denotes findings
T15641 40289-40296 VB denotes suggest
T15642 40297-40301 IN denotes that
T15643 40302-40307 JJ denotes other
T15644 40308-40311 NNP denotes Akt
T15645 40312-40319 NN denotes targets
T15646 40320-40330 VB denotes contribute
T15647 40331-40333 TO denotes to
T15648 40334-40343 JJ denotes malignant
T15649 40344-40355 NN denotes progression
T15650 40357-40360 CD denotes One
T15651 40361-40364 JJ denotes key
T15652 40365-40371 NN denotes target
T15653 40372-40374 VB denotes is
T15654 40375-40381 RB denotes likely
T15655 40382-40385 DT denotes the
T15656 40386-40396 NN denotes inhibition
T15657 40397-40399 IN denotes of
T15658 40400-40403 DT denotes the
T15659 40404-40409 NN denotes Fox01
T15660 40410-40423 NN denotes transcription
T15661 40424-40431 NN denotes factors
T15662 40433-40443 NN denotes Repression
T15663 40444-40446 IN denotes of
T15664 40447-40450 DT denotes the
T15665 40451-40464 JJ denotes pro-apoptotic
T15666 40465-40478 NN denotes transcription
T15667 40479-40485 NN denotes factor
T15668 40486-40491 NN denotes FoxO1
T15669 40492-40494 IN denotes in
T15670 40495-40496 DT denotes a
T15671 40497-40511 JJ denotes PI3K-dependent
T15672 40512-40518 NN denotes manner
T15673 40519-40522 MD denotes can
T15674 40523-40530 VB denotes inhibit
T15675 40531-40541 NN denotes expression
T15676 40542-40544 IN denotes of
T15677 40545-40549 NN denotes bcl6
T15678 40549-40550 -COMMA- denotes ,
T15679 40551-40552 DT denotes a
T15680 40553-40566 NN denotes transcription
T15681 40567-40573 NN denotes factor
T15682 40574-40583 JJ denotes necessary
T15683 40584-40587 IN denotes for
T15684 40588-40590 NN denotes GC
T15685 40591-40600 NN denotes formation
T15686 40601-40602 -LRB- denotes [
T15687 40602-40607 CD denotes 49,70
T15688 40607-40608 -RRB- denotes ]
T15689 40610-40612 PRP denotes It
T15690 40613-40616 VB denotes has
T15691 40617-40621 VB denotes been
T15692 40622-40627 VB denotes shown
T15693 40628-40632 IN denotes that
T15694 40633-40648 NN denotes overstimulation
T15695 40649-40651 IN denotes of
T15696 40652-40656 NN denotes CD40
T15697 40657-40666 NN denotes signaling
T15698 40667-40671 IN denotes with
T15699 40672-40681 JJ denotes agonistic
T15700 40682-40692 NN denotes antibodies
T15701 40693-40701 VB denotes inhibits
T15702 40702-40704 NN denotes GC
T15703 40705-40714 NN denotes formation
T15704 40715-40716 -LRB- denotes [
T15705 40716-40718 CD denotes 71
T15706 40718-40719 -RRB- denotes ]
T15707 40721-40730 RB denotes Similarly
T15708 40730-40731 -COMMA- denotes ,
T15709 40732-40735 JJ denotes due
T15710 40736-40738 TO denotes to
T15711 40739-40746 NN denotes mimicry
T15712 40747-40749 IN denotes of
T15713 40750-40754 NN denotes CD40
T15714 40755-40764 NN denotes signaling
T15715 40764-40765 -COMMA- denotes ,
T15716 40766-40776 JJ denotes transgenic
T15717 40777-40781 NN denotes LMP1
T15718 40782-40786 NN denotes mice
T15719 40787-40790 VB denotes are
T15720 40791-40795 RB denotes also
T15721 40796-40805 JJ denotes defective
T15722 40806-40808 IN denotes in
T15723 40809-40811 NN denotes GC
T15724 40812-40821 NN denotes formation
T15725 40822-40823 -LRB- denotes [
T15726 40823-40828 CD denotes 23,49
T15727 40828-40829 -RRB- denotes ]
T15728 40831-40834 DT denotes The
T15729 40835-40847 JJ denotes constitutive
T15730 40848-40857 NN denotes signaling
T15731 40858-40860 IN denotes by
T15732 40861-40865 NN denotes LMP1
T15733 40866-40872 RB denotes likely
T15734 40873-40879 VB denotes blocks
T15735 40880-40882 NN denotes GC
T15736 40883-40892 NN denotes formation
T15737 40893-40900 IN denotes through
T15738 40901-40915 NN denotes downregulation
T15739 40916-40918 IN denotes of
T15740 40919-40923 NN denotes bcl6
T15741 40925-40938 RB denotes Interestingly
T15742 40938-40939 -COMMA- denotes ,
T15743 40940-40948 JJ denotes clinical
T15744 40949-40956 NN denotes studies
T15745 40957-40965 VB denotes indicate
T15746 40966-40970 IN denotes that
T15747 40971-40981 NN denotes expression
T15748 40982-40984 IN denotes of
T15749 40985-40989 NN denotes LMP1
T15750 40990-40993 CC denotes and
T15751 40994-40998 NN denotes bcl6
T15752 40999-41002 VB denotes are
T15753 41003-41011 RB denotes mutually
T15754 41012-41021 JJ denotes exclusive
T15755 41022-41024 IN denotes in
T15756 41025-41031 JJ denotes non-HD
T15757 41032-41035 CC denotes and
T15758 41036-41045 JJ denotes classical
T15759 41046-41048 NN denotes HD
T15760 41049-41050 -LRB- denotes [
T15761 41050-41055 CD denotes 72,73
T15762 41055-41056 -RRB- denotes ]
T15763 41058-41062 RB denotes Thus
T15764 41062-41063 -COMMA- denotes ,
T15765 41064-41067 DT denotes the
T15766 41068-41072 NN denotes LMP1
T15767 41073-41083 JJ denotes transgenic
T15768 41084-41093 NN denotes lymphomas
T15769 41094-41100 VB denotes mirror
T15770 41101-41108 NN denotes aspects
T15771 41109-41111 IN denotes of
T15772 41112-41123 JJ denotes EBV-induced
T15773 41124-41126 NN denotes HD
T15774 41128-41136 IN denotes Although
T15775 41137-41140 DT denotes the
T15776 41141-41151 NN denotes activation
T15777 41152-41154 IN denotes of
T15778 41155-41158 NN denotes Akt
T15779 41159-41162 CC denotes and
T15780 41163-41166 DT denotes the
T15781 41167-41171 NN denotes lack
T15782 41172-41174 IN denotes of
T15783 41175-41180 NN denotes Fox01
T15784 41181-41183 IN denotes in
T15785 41184-41187 DT denotes the
T15786 41188-41196 NN denotes lymphoma
T15787 41197-41202 NN denotes cells
T15788 41203-41210 VB denotes suggest
T15789 41211-41215 IN denotes that
T15790 41216-41220 NN denotes LMP1
T15791 41221-41228 VB denotes affects
T15792 41229-41233 NN denotes bcl6
T15793 41234-41237 CC denotes and
T15794 41238-41240 NN denotes GC
T15795 41241-41250 NN denotes formation
T15796 41251-41258 IN denotes through
T15797 41259-41263 DT denotes this
T15798 41264-41271 NN denotes pathway
T15799 41271-41272 -COMMA- denotes ,
T15800 41273-41283 NN denotes regulation
T15801 41284-41286 IN denotes of
T15802 41287-41292 JJ denotes other
T15803 41293-41301 NNP denotes Forkhead
T15804 41302-41309 NN denotes targets
T15805 41310-41318 VB denotes involved
T15806 41319-41321 IN denotes in
T15807 41322-41326 NN denotes cell
T15808 41327-41332 NN denotes cycle
T15809 41333-41344 NN denotes progression
T15810 41344-41345 -COMMA- denotes ,
T15811 41346-41350 JJ denotes such
T15812 41351-41353 IN denotes as
T15813 41354-41357 NN denotes p27
T15814 41358-41361 CC denotes and
T15815 41362-41370 NN denotes CyclinD2
T15816 41370-41371 -COMMA- denotes ,
T15817 41372-41378 RB denotes likely
T15818 41379-41389 VB denotes contribute
T15819 41390-41392 TO denotes to
T15820 41393-41402 JJ denotes malignant
T15821 41403-41417 NN denotes transformation
T15822 41419-41425 RB denotes Indeed
T15823 41425-41426 -COMMA- denotes ,
T15824 41427-41431 NN denotes loss
T15825 41432-41434 IN denotes of
T15826 41435-41440 NN denotes FoxO1
T15827 41441-41451 NN denotes expression
T15828 41452-41454 IN denotes in
T15829 41455-41463 NN denotes lymphoma
T15830 41464-41469 NN denotes cells
T15831 41470-41480 VB denotes correlated
T15832 41481-41485 IN denotes with
T15833 41486-41487 DT denotes a
T15834 41488-41492 NN denotes loss
T15835 41493-41495 IN denotes of
T15836 41496-41499 NN denotes p27
T15837 41500-41501 -LRB- denotes (
T15838 41501-41507 NN denotes Figure
T15839 41508-41510 NN denotes 6B
T15840 41511-41514 CC denotes and
T15841 41515-41517 NN denotes 6C
T15842 41517-41518 -RRB- denotes )
T15843 41520-41528 NN denotes CyclinD2
T15844 41529-41532 VB denotes has
T15845 41533-41537 RB denotes also
T15846 41538-41542 VB denotes been
T15847 41543-41548 VB denotes shown
T15848 41549-41551 TO denotes to
T15849 41552-41554 VB denotes be
T15850 41555-41566 VB denotes upregulated
T15851 41567-41569 IN denotes by
T15852 41570-41574 NN denotes LMP1
T15853 41575-41582 IN denotes through
T15854 41583-41590 NN denotes release
T15855 41591-41593 IN denotes of
T15856 41594-41608 JJ denotes FoxO1-mediated
T15857 41609-41619 NN denotes repression
T15858 41620-41621 -LRB- denotes [
T15859 41621-41623 CD denotes 70
T15860 41623-41624 -RRB- denotes ]
T15861 41626-41628 IN denotes In
T15862 41629-41636 NN denotes summary
T15863 41636-41637 -COMMA- denotes ,
T15864 41638-41640 IN denotes in
T15865 41641-41645 DT denotes this
T15866 41646-41656 JJ denotes transgenic
T15867 41657-41662 NN denotes model
T15868 41663-41665 IN denotes of
T15869 41666-41681 NN denotes lymphomagenesis
T15870 41681-41682 -COMMA- denotes ,
T15871 41683-41687 NN denotes LMP1
T15872 41688-41696 VB denotes promotes
T15873 41697-41707 NN denotes malignancy
T15874 41708-41710 IN denotes in
T15875 41711-41715 NN denotes B-1a
T15876 41716-41721 NN denotes cells
T15877 41721-41722 -COMMA- denotes ,
T15878 41723-41724 DT denotes a
T15879 41725-41735 NN denotes population
T15880 41736-41740 WDT denotes that
T15881 41741-41743 VB denotes is
T15882 41744-41755 VB denotes predisposed
T15883 41756-41758 TO denotes to
T15884 41759-41765 JJ denotes clonal
T15885 41766-41775 NN denotes expansion
T15886 41776-41780 IN denotes with
T15887 41781-41784 NN denotes age
T15888 41786-41789 DT denotes The
T15889 41790-41799 JJ denotes malignant
T15890 41800-41811 NN denotes lymphocytes
T15891 41812-41816 VB denotes were
T15892 41817-41830 VB denotes distinguished
T15893 41831-41833 IN denotes by
T15894 41834-41848 RB denotes constitutively
T15895 41849-41855 JJ denotes active
T15896 41856-41861 NN denotes Stat3
T15897 41862-41871 NN denotes signaling
T15898 41871-41872 -COMMA- denotes ,
T15899 41873-41882 VB denotes decreased
T15900 41883-41886 NN denotes p27
T15901 41886-41887 -COMMA- denotes ,
T15902 41888-41891 CC denotes and
T15903 41892-41901 VB denotes activated
T15904 41902-41905 NN denotes Akt
T15905 41906-41909 CC denotes and
T15906 41910-41914 NN denotes NFκB
T15907 41915-41923 NN denotes pathways
T15908 41923-41924 -COMMA- denotes ,
T15909 41925-41935 NN denotes properties
T15910 41936-41940 WDT denotes that
T15911 41941-41944 VB denotes are
T15912 41945-41955 VB denotes associated
T15913 41956-41960 IN denotes with
T15914 41961-41970 VB denotes promoting
T15915 41971-41974 DT denotes the
T15916 41975-41981 NN denotes growth
T15917 41982-41985 CC denotes and
T15918 41986-41994 NN denotes survival
T15919 41995-41997 IN denotes of
T15920 41998-41999 NN denotes B
T15921 42000-42011 NN denotes lymphocytes
T15922 42013-42024 RB denotes Importantly
T15923 42024-42025 -COMMA- denotes ,
T15924 42026-42029 NN denotes Akt
T15925 42029-42030 -COMMA- denotes ,
T15926 42031-42035 NN denotes NFκB
T15927 42035-42036 -COMMA- denotes ,
T15928 42037-42040 CC denotes and
T15929 42041-42046 NN denotes Stat3
T15930 42047-42055 NN denotes pathways
T15931 42056-42060 VB denotes were
T15932 42061-42071 RB denotes critically
T15933 42072-42080 VB denotes required
T15934 42081-42084 IN denotes for
T15935 42085-42088 DT denotes the
T15936 42089-42095 NN denotes growth
T15937 42096-42099 CC denotes and
T15938 42100-42108 NN denotes survival
T15939 42109-42111 IN denotes of
T15940 42112-42121 JJ denotes malignant
T15941 42122-42133 NN denotes lymphocytes
T15942 42134-42136 RB denotes as
T15943 42137-42141 RB denotes well
T15944 42142-42144 IN denotes as
T15945 42145-42152 JJ denotes healthy
T15946 42153-42157 NN denotes LMP1
T15947 42158-42168 JJ denotes transgenic
T15948 42169-42180 NN denotes lymphocytes
T15949 42182-42185 DT denotes The
T15950 42186-42192 NN denotes growth
T15951 42193-42195 IN denotes of
T15952 42196-42211 JJ denotes EBV-transformed
T15953 42212-42223 NN denotes lymphocytes
T15954 42224-42228 RB denotes also
T15955 42229-42237 VB denotes requires
T15956 42238-42248 NN denotes activation
T15957 42249-42251 IN denotes of
T15958 42252-42256 NN denotes NFκB
T15959 42256-42257 -COMMA- denotes ,
T15960 42258-42261 CC denotes and
T15961 42262-42267 DT denotes these
T15962 42268-42275 NN denotes studies
T15963 42276-42283 VB denotes provide
T15964 42284-42291 NN denotes insight
T15965 42292-42296 IN denotes into
T15966 42297-42300 WRB denotes how
T15967 42301-42305 NN denotes LMP1
T15968 42306-42317 VB denotes contributes
T15969 42318-42320 TO denotes to
T15970 42321-42335 JJ denotes EBV-associated
T15971 42336-42350 NN denotes transformation
T15972 42352-42355 DT denotes The
T15973 42356-42366 JJ denotes transgenic
T15974 42367-42376 NN denotes lymphomas
T15975 42377-42383 VB denotes mirror
T15976 42384-42392 JJ denotes multiple
T15977 42393-42400 NN denotes aspects
T15978 42401-42403 IN denotes of
T15979 42404-42415 JJ denotes EBV-induced
T15980 42416-42422 NN denotes tumors
T15981 42423-42426 CC denotes and
T15982 42427-42434 VB denotes suggest
T15983 42435-42439 IN denotes that
T15984 42440-42442 FW denotes in
T15985 42443-42447 FW denotes vivo
T15986 42448-42453 DT denotes these
T15987 42454-42464 NN denotes properties
T15988 42465-42467 IN denotes of
T15989 42468-42472 NN denotes LMP1
T15990 42473-42476 VB denotes are
T15991 42477-42482 JJ denotes major
T15992 42483-42490 NN denotes factors
T15993 42491-42493 IN denotes in
T15994 42494-42497 DT denotes the
T15995 42498-42509 NN denotes development
T15996 42510-42512 IN denotes of
T15997 42513-42519 NN denotes cancer
T18295 42545-42555 JJ denotes Transgenic
T18296 42556-42560 NN denotes mice
T18297 42562-42572 NN denotes Generation
T18298 42573-42575 IN denotes of
T18299 42576-42580 NN denotes LMP1
T18300 42581-42585 NN denotes mice
T18301 42586-42591 IN denotes under
T18302 42592-42595 DT denotes the
T18303 42596-42598 NN denotes Ig
T18304 42599-42604 JJ denotes heavy
T18305 42605-42610 NN denotes chain
T18306 42611-42619 NN denotes promoter
T18307 42620-42623 CC denotes and
T18308 42624-42632 NN denotes enhancer
T18309 42633-42637 VB denotes have
T18310 42638-42642 VB denotes been
T18311 42643-42652 VB denotes described
T18312 42653-42663 RB denotes previously
T18313 42664-42667 CC denotes and
T18314 42668-42672 VB denotes were
T18315 42673-42683 VB denotes maintained
T18316 42684-42686 IN denotes as
T18317 42687-42700 NN denotes heterozygotes
T18318 42701-42703 IN denotes on
T18319 42704-42705 DT denotes a
T18320 42706-42711 NN denotes Balbc
T18321 42712-42722 NN denotes background
T18322 42723-42724 -LRB- denotes [
T18323 42724-42726 CD denotes 26
T18324 42726-42727 -RRB- denotes ]
T18325 42729-42733 NN denotes LMP1
T18326 42734-42738 NN denotes mice
T18327 42739-42743 VB denotes were
T18328 42744-42753 VB denotes genotyped
T18329 42754-42756 IN denotes by
T18330 42757-42765 JJ denotes Southern
T18331 42766-42770 NN denotes blot
T18332 42771-42774 CC denotes and
T18333 42775-42778 NN denotes PCR
T18334 42779-42787 NN denotes analysis
T18335 42788-42790 IN denotes of
T18336 42791-42795 NN denotes tail
T18337 42796-42799 NN denotes DNA
T18338 42800-42802 IN denotes as
T18339 42803-42812 VB denotes described
T18340 42813-42823 RB denotes previously
T18341 42824-42825 -LRB- denotes [
T18342 42825-42827 CD denotes 26
T18343 42827-42828 -RRB- denotes ]
T18344 42830-42836 NN denotes Spleen
T18345 42837-42840 CC denotes and
T18346 42841-42846 NN denotes liver
T18347 42847-42855 NN denotes sections
T18348 42856-42860 VB denotes were
T18349 42861-42866 VB denotes fixed
T18350 42867-42869 IN denotes in
T18351 42870-42871 CD denotes 4
T18352 42871-42872 NN denotes %
T18353 42873-42889 NN denotes paraformaldehyde
T18354 42890-42893 CC denotes and
T18355 42894-42902 VB denotes embedded
T18356 42903-42905 IN denotes in
T18357 42906-42914 NN denotes paraffin
T18358 42914-42915 -COMMA- denotes ,
T18359 42916-42919 CC denotes and
T18360 42920-42924 JJ denotes 5-μm
T18361 42925-42933 NN denotes sections
T18362 42934-42938 VB denotes were
T18363 42939-42946 VB denotes stained
T18364 42947-42951 IN denotes with
T18365 42952-42963 NN denotes hematoxylin
T18366 42964-42967 CC denotes and
T18367 42968-42973 NN denotes eosin
T18368 42974-42977 IN denotes for
T18369 42978-42995 JJ denotes histopathological
T18370 42996-43004 NN denotes analysis
T18371 43006-43015 NN denotes Lymphomas
T18372 43016-43020 VB denotes were
T18373 43021-43029 VB denotes passaged
T18374 43030-43032 IN denotes by
T18375 43033-43048 JJ denotes intraperitoneal
T18376 43049-43058 NN denotes injection
T18377 43059-43061 IN denotes of
T18378 43062-43063 CD denotes 1
T18379 43064-43065 NN denotes ×
T18380 43066-43069 CD denotes 108
T18381 43070-43081 NN denotes splenocytes
T18382 43082-43086 IN denotes into
T18383 43087-43091 NN denotes SCID
T18384 43092-43096 NN denotes mice
T18385 43097-43100 CC denotes and
T18386 43101-43111 VB denotes sacrificed
T18387 43112-43116 IN denotes upon
T18388 43117-43128 NN denotes development
T18389 43129-43131 IN denotes of
T18390 43132-43134 DT denotes an
T18391 43135-43143 VB denotes extended
T18392 43144-43151 NN denotes abdomen
T18393 43153-43160 NN denotes Animals
T18394 43161-43165 VB denotes were
T18395 43166-43172 VB denotes housed
T18396 43173-43175 IN denotes in
T18397 43176-43179 DT denotes the
T18398 43180-43191 NNP denotes Association
T18399 43192-43195 IN denotes for
T18400 43196-43206 NNP denotes Assessment
T18401 43207-43210 CC denotes and
T18402 43211-43224 NNP denotes Accreditation
T18403 43225-43228 IN denotes for
T18404 43229-43235 NNP denotes Animal
T18405 43236-43249 NNP denotes Care–approved
T18406 43250-43256 NN denotes animal
T18407 43257-43265 NN denotes facility
T18408 43266-43268 IN denotes at
T18409 43269-43272 DT denotes the
T18410 43273-43283 NNP denotes University
T18411 43284-43286 IN denotes of
T18412 43287-43292 NNP denotes North
T18413 43293-43301 NNP denotes Carolina
T18414 43302-43304 IN denotes at
T18415 43305-43311 NNP denotes Chapel
T18416 43312-43317 NNP denotes Hill.
T18417 43318-43321 DT denotes All
T18418 43322-43331 NN denotes protocols
T18419 43332-43336 VB denotes were
T18420 43337-43345 VB denotes approved
T18421 43346-43348 IN denotes by
T18422 43349-43352 DT denotes the
T18423 43353-43366 NNP denotes Institutional
T18424 43367-43373 NNP denotes Animal
T18425 43374-43378 NNP denotes Care
T18426 43379-43382 CC denotes and
T18427 43383-43386 NNP denotes Use
T18428 43387-43396 NNP denotes Committee
T18617 43399-43408 NN denotes Isolation
T18618 43409-43412 CC denotes and
T18619 43413-43419 NN denotes growth
T18620 43420-43422 IN denotes of
T18621 43423-43424 NN denotes B
T18622 43425-43430 NN denotes cells
T18623 43432-43443 NN denotes Splenocytes
T18624 43444-43448 VB denotes were
T18625 43449-43457 VB denotes prepared
T18626 43458-43460 IN denotes by
T18627 43461-43473 VB denotes homogenizing
T18628 43474-43480 NN denotes spleen
T18629 43481-43487 NN denotes tissue
T18630 43488-43492 IN denotes with
T18631 43493-43496 CD denotes two
T18632 43497-43504 JJ denotes frosted
T18633 43505-43511 NN denotes slides
T18634 43512-43515 CC denotes and
T18635 43516-43522 NN denotes debris
T18636 43523-43526 VB denotes was
T18637 43527-43535 VB denotes filtered
T18638 43536-43543 IN denotes through
T18639 43544-43545 DT denotes a
T18640 43546-43552 JJ denotes 100-μm
T18641 43553-43557 NN denotes cell
T18642 43558-43566 NN denotes strainer
T18643 43568-43580 NN denotes Erythrocytes
T18644 43581-43585 VB denotes were
T18645 43586-43591 VB denotes lysed
T18646 43592-43597 VB denotes using
T18647 43598-43601 CD denotes 0.8
T18648 43601-43602 NN denotes %
T18649 43603-43611 NN denotes ammonium
T18650 43612-43620 NN denotes chloride
T18651 43621-43629 NN denotes solution
T18652 43630-43631 -LRB- denotes (
T18653 43631-43639 NNP denotes StemCell
T18654 43640-43652 NNP denotes Technologies
T18655 43652-43653 -RRB- denotes )
T18656 43654-43657 IN denotes for
T18657 43658-43660 CD denotes 10
T18658 43661-43664 NN denotes min
T18659 43665-43667 IN denotes on
T18660 43668-43671 NN denotes ice
T18661 43672-43675 CC denotes and
T18662 43676-43682 VB denotes washed
T18663 43683-43688 RB denotes twice
T18664 43689-43693 IN denotes with
T18665 43694-43697 NNP denotes PBS
T18666 43699-43700 NN denotes B
T18667 43701-43706 NN denotes cells
T18668 43707-43711 VB denotes were
T18669 43712-43720 VB denotes isolated
T18670 43721-43726 VB denotes using
T18671 43727-43736 JJ denotes CD19-MACS
T18672 43737-43742 NN denotes beads
T18673 43743-43752 VB denotes according
T18674 43753-43755 TO denotes to
T18675 43756-43759 DT denotes the
T18676 43760-43772 NN denotes manufacturer
T18677 43772-43774 POS denotes 's
T18678 43775-43787 NN denotes instructions
T18679 43788-43789 -LRB- denotes (
T18680 43789-43797 NNP denotes Miltenyi
T18681 43798-43804 NNP denotes Biotec
T18682 43804-43805 -RRB- denotes )
T18683 43806-43809 CC denotes and
T18684 43810-43815 VB denotes grown
T18685 43816-43818 IN denotes in
T18686 43819-43825 NNP denotes Iscove
T18687 43825-43827 POS denotes 's
T18688 43828-43834 NN denotes medium
T18689 43835-43847 VB denotes supplemented
T18690 43848-43852 IN denotes with
T18691 43853-43869 JJ denotes heat-inactivated
T18692 43870-43872 CD denotes 10
T18693 43872-43873 NN denotes %
T18694 43874-43879 JJ denotes fetal
T18695 43880-43886 JJ denotes bovine
T18696 43887-43892 NN denotes serum
T18697 43893-43896 CC denotes and
T18698 43897-43919 JJ denotes antibiotic/antimycotic
T18699 43920-43921 -LRB- denotes (
T18700 43921-43926 NN denotes GIBCO
T18701 43926-43927 -RRB- denotes )
T18702 43929-43940 NN denotes Splenocytes
T18703 43941-43949 VB denotes isolated
T18704 43950-43954 IN denotes from
T18705 43955-43968 JJ denotes SCID-passaged
T18706 43969-43978 NN denotes lymphomas
T18707 43979-43988 VB denotes consisted
T18708 43989-43991 IN denotes of
T18709 43992-43994 CD denotes 80
T18710 43994-43995 NN denotes %
T18711 43995-43998 CD denotes –90
T18712 43998-43999 NN denotes %
T18713 44000-44001 NN denotes B
T18714 44002-44007 NN denotes cells
T18715 44008-44010 IN denotes as
T18716 44011-44021 VB denotes determined
T18717 44022-44024 IN denotes by
T18718 44025-44029 NN denotes flow
T18719 44030-44039 NN denotes cytometry
T18720 44039-44040 -COMMA- denotes ,
T18721 44041-44044 CC denotes and
T18722 44045-44049 VB denotes were
T18723 44050-44055 RB denotes hence
T18724 44056-44059 RB denotes not
T18725 44060-44067 RB denotes further
T18726 44068-44076 VB denotes purified
T18727 44077-44081 IN denotes with
T18728 44082-44091 JJ denotes CD19-MACS
T18729 44092-44097 NN denotes beads
T18730 44099-44110 NN denotes Splenocytes
T18731 44111-44115 VB denotes were
T18732 44116-44122 VB denotes seeded
T18733 44123-44125 IN denotes at
T18734 44126-44130 CD denotes 1.25
T18735 44131-44132 CC denotes ×
T18736 44133-44136 CD denotes 106
T18737 44137-44145 NN denotes cells/ml
T18738 44146-44149 CC denotes and
T18739 44150-44155 WRB denotes where
T18740 44156-44166 JJ denotes applicable
T18741 44166-44167 -COMMA- denotes ,
T18742 44168-44179 JJ denotes recombinant
T18743 44180-44185 NN denotes mouse
T18744 44186-44189 NN denotes IL4
T18745 44190-44193 VB denotes was
T18746 44194-44199 VB denotes added
T18747 44200-44202 IN denotes at
T18748 44203-44206 CD denotes 100
T18749 44207-44212 NN denotes ng/ml
T18750 44212-44213 -COMMA- denotes ,
T18751 44214-44225 JJ denotes recombinant
T18752 44226-44231 NN denotes mouse
T18753 44232-44236 NN denotes IL10
T18754 44237-44239 IN denotes at
T18755 44240-44242 CD denotes 10
T18756 44243-44248 NN denotes ng/ml
T18757 44248-44249 -COMMA- denotes ,
T18758 44250-44253 CC denotes and
T18759 44254-44257 NN denotes rat
T18760 44258-44262 NN denotes IgG1
T18761 44263-44273 JJ denotes anti-mouse
T18762 44274-44278 NN denotes IL10
T18763 44279-44282 CC denotes and
T18764 44283-44286 NN denotes rat
T18765 44287-44291 NN denotes IgG1
T18766 44292-44299 NN denotes isotype
T18767 44300-44307 NN denotes control
T18768 44308-44310 IN denotes at
T18769 44311-44313 CD denotes 10
T18770 44314-44319 NN denotes μg/ml
T18771 44320-44321 -LRB- denotes (
T18772 44321-44322 NNP denotes R
T18773 44322-44323 CC denotes &
T18774 44323-44324 NNP denotes D
T18775 44325-44332 NNP denotes Systems
T18776 44332-44333 -RRB- denotes )
T18777 44335-44338 IN denotes For
T18778 44339-44343 NN denotes BrdU
T18779 44344-44357 NN denotes incorporation
T18780 44358-44364 NN denotes assays
T18781 44364-44365 -COMMA- denotes ,
T18782 44366-44377 NN denotes splenocytes
T18783 44378-44382 VB denotes were
T18784 44383-44389 VB denotes pulsed
T18785 44390-44393 IN denotes for
T18786 44394-44396 CD denotes 24
T18787 44397-44398 NN denotes h
T18788 44399-44403 IN denotes with
T18789 44404-44406 CD denotes 10
T18790 44407-44409 NNP denotes μM
T18791 44410-44414 NNP denotes BrdU
T18792 44415-44416 CD denotes 1
T18793 44417-44418 NN denotes d
T18794 44419-44431 JJ denotes post-harvest
T19051 44434-44437 NN denotes MTS
T19052 44438-44443 NN denotes assay
T19053 44445-44448 DT denotes The
T19054 44449-44451 CD denotes 3-
T19055 44451-44452 -LRB- denotes (
T19056 44452-44453 CD denotes 4
T19057 44453-44454 -COMMA- denotes ,
T19058 44455-44477 NN denotes 5-dimethylthiazol-2-yl
T19059 44477-44478 -RRB- denotes )
T19060 44478-44481 CD denotes -5-
T19061 44481-44482 -LRB- denotes (
T19062 44482-44504 NN denotes 3-carboxymethoxyphenyl
T19063 44504-44505 -RRB- denotes )
T19064 44505-44508 CD denotes -2-
T19065 44508-44509 -LRB- denotes (
T19066 44509-44522 NN denotes 4-sulfophenyl
T19067 44522-44523 -RRB- denotes )
T19068 44523-44538 NN denotes -2H-tetrazolium
T19069 44539-44544 JJ denotes inner
T19070 44545-44549 NN denotes salt
T19071 44550-44551 -LRB- denotes (
T19072 44551-44554 NN denotes MTS
T19073 44554-44555 -RRB- denotes )
T19074 44556-44560 NN denotes cell
T19075 44561-44587 NN denotes cytotoxicity/proliferation
T19076 44588-44594 NN denotes assays
T19077 44595-44599 VB denotes were
T19078 44600-44609 VB denotes performed
T19079 44610-44615 VB denotes using
T19080 44616-44619 DT denotes the
T19081 44620-44629 NNP denotes CellTiter
T19082 44630-44632 CD denotes 96
T19083 44633-44640 JJ denotes aqueous
T19084 44641-44653 NN denotes one-solution
T19085 44654-44658 NN denotes cell
T19086 44659-44672 NN denotes proliferation
T19087 44673-44678 NN denotes assay
T19088 44679-44680 -LRB- denotes (
T19089 44680-44687 NN denotes Promega
T19090 44687-44688 -RRB- denotes )
T19091 44688-44689 -COMMA- denotes ,
T19092 44690-44699 VB denotes according
T19093 44700-44702 TO denotes to
T19094 44703-44715 NN denotes manufacturer
T19095 44715-44717 POS denotes 's
T19096 44718-44730 NN denotes instructions
T19097 44732-44735 IN denotes For
T19098 44736-44739 NN denotes IL4
T19099 44740-44747 NN denotes studies
T19100 44747-44748 -COMMA- denotes ,
T19101 44749-44760 NN denotes splenocytes
T19102 44761-44765 VB denotes were
T19103 44766-44774 VB denotes cultured
T19104 44775-44778 IN denotes for
T19105 44779-44780 CD denotes 3
T19106 44781-44782 NN denotes d
T19107 44783-44785 IN denotes in
T19108 44786-44789 DT denotes the
T19109 44790-44798 NN denotes presence
T19110 44799-44801 CC denotes or
T19111 44802-44809 NN denotes absence
T19112 44810-44812 IN denotes of
T19113 44813-44816 CD denotes 100
T19114 44817-44822 NN denotes ng/ml
T19115 44823-44826 NN denotes IL4
T19116 44828-44833 NN denotes Cells
T19117 44834-44838 VB denotes were
T19118 44839-44845 VB denotes seeded
T19119 44846-44848 IN denotes on
T19120 44849-44852 NN denotes day
T19121 44853-44854 CD denotes 3
T19122 44855-44857 IN denotes in
T19123 44858-44868 NN denotes triplicate
T19124 44869-44871 IN denotes in
T19125 44872-44873 DT denotes a
T19126 44874-44881 JJ denotes 96-well
T19127 44882-44887 NN denotes plate
T19128 44888-44890 IN denotes at
T19129 44891-44894 CD denotes 2.5
T19130 44895-44896 CC denotes ×
T19131 44897-44900 CD denotes 106
T19132 44901-44909 NN denotes cells/ml
T19133 44910-44912 IN denotes at
T19134 44913-44916 CD denotes 100
T19135 44917-44919 NN denotes μl
T19136 44920-44923 IN denotes per
T19137 44924-44928 RB denotes well
T19138 44930-44933 NN denotes MTS
T19139 44934-44941 NN denotes reagent
T19140 44942-44945 VB denotes was
T19141 44946-44951 VB denotes added
T19142 44952-44955 IN denotes for
T19143 44956-44957 CD denotes 4
T19144 44958-44959 NN denotes h
T19145 44960-44963 CC denotes and
T19146 44964-44974 NN denotes absorbance
T19147 44975-44978 VB denotes was
T19148 44979-44983 VB denotes read
T19149 44984-44986 IN denotes at
T19150 44987-44990 CD denotes 540
T19151 44991-44993 NN denotes nm
T19152 44993-44994 -COLON- denotes ;
T19153 44995-45001 NN denotes values
T19154 45002-45009 VB denotes plotted
T19155 45010-45014 VB denotes were
T19156 45015-45025 VB denotes subtracted
T19157 45026-45030 IN denotes from
T19158 45031-45037 NN denotes blanks
T19159 45039-45042 IN denotes For
T19160 45043-45057 NN denotes neutralization
T19161 45058-45064 NN denotes assays
T19162 45064-45065 -COMMA- denotes ,
T19163 45066-45077 NN denotes splenocytes
T19164 45078-45082 VB denotes were
T19165 45083-45089 VB denotes seeded
T19166 45090-45092 IN denotes at
T19167 45093-45094 CD denotes 5
T19168 45095-45096 -COLON- denotes ×
T19169 45097-45100 CD denotes 106
T19170 45101-45109 NN denotes cells/ml
T19171 45110-45112 IN denotes at
T19172 45113-45116 CD denotes 100
T19173 45117-45119 NN denotes μl
T19174 45120-45123 IN denotes per
T19175 45124-45128 RB denotes well
T19176 45129-45131 IN denotes on
T19177 45132-45135 NN denotes day
T19178 45136-45138 IN denotes of
T19179 45139-45146 NN denotes harvest
T19180 45147-45150 CC denotes and
T19181 45151-45154 NN denotes IL4
T19182 45154-45155 -COMMA- denotes ,
T19183 45156-45159 NN denotes rat
T19184 45160-45164 NN denotes IgG1
T19185 45165-45175 JJ denotes anti-mouse
T19186 45176-45179 NN denotes IL4
T19187 45179-45180 -COMMA- denotes ,
T19188 45181-45183 CC denotes or
T19189 45184-45187 NN denotes rat
T19190 45188-45192 NN denotes IgG1
T19191 45193-45200 NN denotes isotype
T19192 45201-45208 NN denotes control
T19193 45209-45210 -LRB- denotes (
T19194 45210-45211 NNP denotes R
T19195 45211-45212 CC denotes &
T19196 45212-45213 NNP denotes D
T19197 45214-45221 NNP denotes Systems
T19198 45221-45222 -RRB- denotes )
T19199 45223-45227 VB denotes were
T19200 45228-45233 VB denotes added
T19201 45234-45236 IN denotes at
T19202 45237-45240 DT denotes the
T19203 45241-45255 NN denotes concentrations
T19204 45256-45265 VB denotes indicated
T19205 45266-45268 IN denotes in
T19206 45269-45272 DT denotes the
T19207 45273-45280 NN denotes figures
T19208 45282-45290 NN denotes Cultures
T19209 45291-45295 VB denotes were
T19210 45296-45302 VB denotes pulsed
T19211 45303-45306 IN denotes for
T19212 45307-45308 CD denotes 4
T19213 45309-45310 NN denotes h
T19214 45311-45315 IN denotes with
T19215 45316-45319 NN denotes MTS
T19216 45320-45327 NN denotes reagent
T19217 45328-45329 CD denotes 1
T19218 45330-45331 NN denotes d
T19219 45332-45344 JJ denotes post-seeding
T19220 45346-45349 IN denotes For
T19221 45350-45359 NN denotes inhibitor
T19222 45360-45367 NN denotes studies
T19223 45367-45368 -COMMA- denotes ,
T19224 45369-45380 NN denotes splenocytes
T19225 45381-45385 VB denotes were
T19226 45386-45392 VB denotes seeded
T19227 45393-45395 IN denotes at
T19228 45396-45397 CD denotes 1
T19229 45398-45399 NN denotes ×
T19230 45400-45403 CD denotes 107
T19231 45404-45412 NN denotes cells/ml
T19232 45413-45415 IN denotes at
T19233 45416-45419 CD denotes 100
T19234 45420-45422 NN denotes μl
T19235 45423-45426 IN denotes per
T19236 45427-45431 RB denotes well
T19237 45432-45434 IN denotes on
T19238 45435-45438 NN denotes day
T19239 45439-45441 IN denotes of
T19240 45442-45449 NN denotes harvest
T19241 45449-45450 -COMMA- denotes ,
T19242 45451-45454 CC denotes and
T19243 45455-45465 NN denotes inhibitors
T19244 45466-45470 VB denotes were
T19245 45471-45476 VB denotes added
T19246 45477-45479 IN denotes at
T19247 45480-45483 DT denotes the
T19248 45484-45498 NN denotes concentrations
T19249 45499-45508 VB denotes indicated
T19250 45509-45511 IN denotes in
T19251 45512-45515 DT denotes the
T19252 45516-45523 NN denotes figures
T19253 45525-45528 DT denotes The
T19254 45529-45539 NN denotes inhibitors
T19255 45540-45550 NN denotes BAY11–7085
T19256 45550-45551 -COMMA- denotes ,
T19257 45552-45561 NN denotes rapamycin
T19258 45561-45562 -COMMA- denotes ,
T19259 45563-45574 NN denotes triciribine
T19260 45574-45575 -COMMA- denotes ,
T19261 45576-45581 NN denotes U0126
T19262 45581-45582 -COMMA- denotes ,
T19263 45583-45591 NN denotes SB202190
T19264 45591-45592 -COMMA- denotes ,
T19265 45593-45596 CC denotes and
T19266 45597-45609 NN denotes cucurbitacin
T19267 45610-45611 PRP denotes I
T19268 45612-45616 VB denotes were
T19269 45617-45626 VB denotes purchased
T19270 45627-45631 IN denotes from
T19271 45632-45635 NNP denotes EMD
T19272 45636-45648 NNP denotes Biosciences.
T19273 45649-45652 IN denotes For
T19274 45653-45666 JJ denotes non-malignant
T19275 45667-45677 NN denotes splenocyte
T19276 45678-45686 NN denotes cultures
T19277 45686-45687 -COMMA- denotes ,
T19278 45688-45689 NN denotes B
T19279 45690-45694 NN denotes cell
T19280 45695-45705 NN denotes activation
T19281 45706-45709 VB denotes was
T19282 45710-45717 VB denotes induced
T19283 45718-45722 IN denotes with
T19284 45723-45725 CD denotes 10
T19285 45726-45731 NN denotes μg/ml
T19286 45732-45734 IN denotes of
T19287 45735-45739 NN denotes goat
T19288 45740-45741 NN denotes F
T19289 45741-45742 -LRB- denotes (
T19290 45742-45744 NN denotes ab
T19291 45744-45745 -DQE- denotes '
T19292 45745-45746 -RRB- denotes )
T19293 45747-45757 JJ denotes anti-mouse
T19294 45758-45761 NN denotes IgM
T19295 45762-45763 -LRB- denotes (
T19296 45763-45770 NNP denotes Jackson
T19297 45771-45785 NNP denotes ImmunoResearch
T19298 45785-45786 -RRB- denotes )
T19299 45788-45796 NN denotes Cultures
T19300 45797-45801 VB denotes were
T19301 45802-45808 VB denotes pulsed
T19302 45809-45812 IN denotes for
T19303 45813-45814 CD denotes 4
T19304 45815-45816 NN denotes h
T19305 45817-45821 IN denotes with
T19306 45822-45825 NN denotes MTS
T19307 45826-45833 NN denotes reagent
T19308 45834-45835 CD denotes 1
T19309 45836-45837 NN denotes d
T19310 45838-45850 JJ denotes post-seeding
T19650 45853-45873 NN denotes Immunohistochemistry
T19651 45875-45892 JJ denotes Paraffin-embedded
T19652 45893-45899 NN denotes spleen
T19653 45900-45908 NN denotes sections
T19654 45909-45913 VB denotes were
T19655 45914-45928 VB denotes deparaffinized
T19656 45929-45931 IN denotes in
T19657 45932-45942 JJ denotes Histoclear
T19658 45943-45944 -LRB- denotes (
T19659 45944-45952 NNP denotes National
T19660 45953-45964 NNP denotes Diagnostics
T19661 45964-45965 -RRB- denotes )
T19662 45966-45969 CC denotes and
T19663 45970-45980 VB denotes rehydrated
T19664 45981-45983 IN denotes in
T19665 45984-45990 VB denotes graded
T19666 45991-45998 NN denotes ethanol
T19667 46000-46008 NN denotes Sections
T19668 46009-46013 VB denotes were
T19669 46014-46021 NN denotes antigen
T19670 46022-46031 VB denotes retrieved
T19671 46032-46034 IN denotes by
T19672 46035-46046 VB denotes microwaving
T19673 46047-46049 IN denotes in
T19674 46050-46057 NN denotes citrate
T19675 46058-46064 NN denotes buffer
T19676 46065-46066 -LRB- denotes (
T19677 46066-46068 NN denotes pH
T19678 46069-46072 CD denotes 6.0
T19679 46072-46073 -RRB- denotes )
T19680 46074-46077 IN denotes for
T19681 46078-46080 CD denotes 15
T19682 46081-46084 NN denotes min
T19683 46085-46086 -LRB- denotes (
T19684 46086-46090 NN denotes LMP1
T19685 46091-46099 NN denotes staining
T19686 46099-46100 -RRB- denotes )
T19687 46101-46104 CC denotes and
T19688 46105-46107 CD denotes 10
T19689 46108-46111 NN denotes min
T19690 46112-46113 -LRB- denotes (
T19691 46113-46119 NN denotes pStat3
T19692 46120-46128 NN denotes staining
T19693 46128-46129 -RRB- denotes )
T19694 46131-46134 IN denotes For
T19695 46135-46139 NN denotes LMP1
T19696 46140-46148 NN denotes staining
T19697 46148-46149 -COMMA- denotes ,
T19698 46150-46158 NN denotes sections
T19699 46159-46163 VB denotes were
T19700 46164-46171 VB denotes blocked
T19701 46172-46176 IN denotes with
T19702 46177-46178 CD denotes 1
T19703 46178-46179 NN denotes %
T19704 46180-46183 NN denotes BSA
T19705 46184-46187 CC denotes and
T19706 46188-46191 CD denotes 0.1
T19707 46191-46192 NN denotes %
T19708 46193-46197 JJ denotes cold
T19709 46198-46202 NN denotes fish
T19710 46203-46207 NN denotes skin
T19711 46208-46215 NN denotes gelatin
T19712 46216-46224 VB denotes followed
T19713 46225-46229 IN denotes with
T19714 46230-46249 NN denotes streptavidin/biotin
T19715 46250-46255 NN denotes block
T19716 46256-46257 -LRB- denotes (
T19717 46257-46263 NNP denotes Vector
T19718 46264-46268 NNP denotes Labs
T19719 46268-46269 -RRB- denotes )
T19720 46271-46274 NN denotes Rat
T19721 46275-46278 NN denotes IgG
T19722 46279-46288 NN denotes anti-LMP1
T19723 46289-46290 -LRB- denotes (
T19724 46290-46296 NN denotes clones
T19725 46297-46300 NN denotes 8G3
T19726 46301-46304 CC denotes and
T19727 46305-46308 NN denotes 1G6
T19728 46308-46309 -COMMA- denotes ,
T19729 46310-46318 NN denotes Ascenion
T19730 46318-46319 -RRB- denotes )
T19731 46320-46324 VB denotes were
T19732 46325-46329 VB denotes used
T19733 46330-46332 IN denotes at
T19734 46333-46334 CD denotes 1
T19735 46334-46335 SYM denotes :
T19736 46335-46337 CD denotes 10
T19737 46338-46346 NN denotes dilution
T19738 46347-46351 IN denotes from
T19739 46352-46358 NN denotes tissue
T19740 46359-46366 NN denotes culture
T19741 46367-46379 NN denotes supernatants
T19742 46379-46380 -COMMA- denotes ,
T19743 46381-46389 VB denotes followed
T19744 46390-46394 IN denotes with
T19745 46395-46396 CD denotes 8
T19746 46397-46402 NN denotes μg/ml
T19747 46403-46415 VB denotes biotinylated
T19748 46416-46421 NN denotes mouse
T19749 46422-46423 NN denotes F
T19750 46423-46424 -LRB- denotes (
T19751 46424-46426 NN denotes ab
T19752 46426-46427 -DQE- denotes '
T19753 46427-46428 -RRB- denotes )
T19754 46429-46437 JJ denotes anti-rat
T19755 46438-46441 NN denotes IgG
T19756 46442-46443 -LRB- denotes (
T19757 46443-46446 NN denotes H+L
T19758 46446-46447 -RRB- denotes )
T19759 46448-46460 JJ denotes pre-adsorbed
T19760 46461-46463 TO denotes to
T19761 46464-46469 NN denotes mouse
T19762 46470-46475 NN denotes serum
T19763 46476-46477 -LRB- denotes (
T19764 46477-46484 NNP denotes Jackson
T19765 46485-46499 NNP denotes ImmunoResearch
T19766 46499-46500 -RRB- denotes )
T19767 46501-46504 CC denotes and
T19768 46505-46506 CD denotes 2
T19769 46507-46512 NN denotes μg/ml
T19770 46513-46534 JJ denotes streptavidin-alkaline
T19771 46535-46546 NN denotes phosphatase
T19772 46547-46556 NN denotes conjugate
T19773 46557-46558 -LRB- denotes (
T19774 46558-46565 NNP denotes Jackson
T19775 46566-46580 NNP denotes ImmunoResearch
T19776 46580-46581 -RRB- denotes )
T19777 46583-46589 NN denotes Stains
T19778 46590-46594 VB denotes were
T19779 46595-46604 VB denotes developed
T19780 46605-46609 IN denotes with
T19781 46610-46618 NN denotes BCIP/NBT
T19782 46619-46622 CC denotes and
T19783 46623-46637 VB denotes counterstained
T19784 46638-46640 IN denotes in
T19785 46641-46648 NNP denotes Nuclear
T19786 46649-46653 NNP denotes Fast
T19787 46654-46657 NNP denotes Red
T19788 46658-46659 -LRB- denotes (
T19789 46659-46663 NNP denotes Dako
T19790 46663-46664 -RRB- denotes )
T19791 46666-46679 NN denotes Phospho-Stat3
T19792 46680-46683 VB denotes was
T19793 46684-46692 VB denotes detected
T19794 46693-46697 IN denotes with
T19795 46698-46699 CD denotes 4
T19796 46700-46705 NN denotes μg/ml
T19797 46706-46708 IN denotes of
T19798 46709-46715 NN denotes pStat3
T19799 46716-46724 NN denotes antibody
T19800 46725-46726 -LRB- denotes (
T19801 46726-46732 NN denotes Tyr705
T19802 46732-46733 -COMMA- denotes ,
T19803 46734-46738 NNP denotes Cell
T19804 46739-46748 NNP denotes Signaling
T19805 46748-46749 -RRB- denotes )
T19806 46750-46753 CC denotes and
T19807 46754-46762 VB denotes detected
T19808 46763-46767 IN denotes with
T19809 46768-46779 JJ denotes anti-rabbit
T19810 46780-46788 NN denotes Poly-HRP
T19811 46789-46792 NN denotes IHC
T19812 46793-46802 NN denotes detection
T19813 46803-46806 NN denotes kit
T19814 46807-46808 -LRB- denotes (
T19815 46808-46816 NNP denotes Chemicon
T19816 46816-46817 -RRB- denotes )
T20045 46820-46824 NN denotes Flow
T20046 46825-46834 NN denotes cytometry
T20047 46836-46839 CD denotes One
T20048 46840-46847 CD denotes million
T20049 46848-46859 NN denotes splenocytes
T20050 46860-46864 VB denotes were
T20051 46865-46872 VB denotes stained
T20052 46873-46877 IN denotes with
T20053 46878-46881 DT denotes the
T20054 46882-46893 JJ denotes appropriate
T20055 46894-46901 JJ denotes primary
T20056 46902-46910 NN denotes antibody
T20057 46911-46923 JJ denotes unconjugated
T20058 46924-46926 CC denotes or
T20059 46927-46937 VB denotes conjugated
T20060 46938-46940 TO denotes to
T20061 46941-46945 NN denotes FITC
T20062 46945-46946 -COMMA- denotes ,
T20063 46947-46949 NN denotes PE
T20064 46949-46950 -COMMA- denotes ,
T20065 46951-46953 CC denotes or
T20066 46954-46957 NN denotes APC
T20067 46958-46965 VB denotes diluted
T20068 46966-46968 IN denotes in
T20069 46969-46974 NN denotes stain
T20070 46975-46981 NN denotes buffer
T20071 46982-46983 -LRB- denotes (
T20072 46983-46986 NN denotes PBS
T20073 46987-46991 IN denotes with
T20074 46992-46993 CD denotes 3
T20075 46993-46994 NN denotes %
T20076 46995-46998 NN denotes FBS
T20077 46998-46999 -RRB- denotes )
T20078 47001-47004 IN denotes For
T20079 47005-47009 NN denotes BrdU
T20080 47010-47019 NN denotes detection
T20081 47019-47020 -COMMA- denotes ,
T20082 47021-47024 DT denotes the
T20083 47025-47034 NN denotes FITC-BrdU
T20084 47035-47039 NN denotes flow
T20085 47040-47043 NN denotes kit
T20086 47044-47047 VB denotes was
T20087 47048-47052 VB denotes used
T20088 47053-47055 IN denotes as
T20089 47056-47066 VB denotes instructed
T20090 47067-47069 IN denotes by
T20091 47070-47073 DT denotes the
T20092 47074-47086 NN denotes manufacturer
T20093 47087-47088 -LRB- denotes (
T20094 47088-47090 NN denotes BD
T20095 47091-47101 NN denotes Bioscience
T20096 47101-47102 -RRB- denotes )
T20097 47104-47111 RB denotes Briefly
T20098 47111-47112 -COMMA- denotes ,
T20099 47113-47118 NN denotes cells
T20100 47119-47123 VB denotes were
T20101 47124-47131 VB denotes exposed
T20102 47132-47134 TO denotes to
T20103 47135-47138 NN denotes EMA
T20104 47139-47140 -LRB- denotes (
T20105 47140-47149 NNP denotes Molecular
T20106 47150-47156 NNP denotes Probes
T20107 47156-47157 -RRB- denotes )
T20108 47158-47161 IN denotes for
T20109 47162-47171 NN denotes exclusion
T20110 47172-47174 IN denotes of
T20111 47175-47179 JJ denotes dead
T20112 47180-47185 NN denotes cells
T20113 47185-47186 -COMMA- denotes ,
T20114 47187-47194 VB denotes stained
T20115 47195-47198 IN denotes for
T20116 47199-47206 NN denotes surface
T20117 47207-47215 NN denotes antigens
T20118 47215-47216 -COMMA- denotes ,
T20119 47217-47222 VB denotes fixed
T20120 47223-47225 IN denotes in
T20121 47226-47242 NN denotes paraformaldehyde
T20122 47242-47243 -COMMA- denotes ,
T20123 47244-47247 CC denotes and
T20124 47248-47261 VB denotes permeabilized
T20125 47262-47266 IN denotes with
T20126 47267-47274 NN denotes saponin
T20127 47276-47278 TO denotes To
T20128 47279-47285 VB denotes expose
T20129 47286-47290 NNP denotes BrdU
T20130 47291-47299 NN denotes epitopes
T20131 47299-47300 -COMMA- denotes ,
T20132 47301-47306 NN denotes cells
T20133 47307-47311 VB denotes were
T20134 47312-47319 VB denotes treated
T20135 47320-47324 IN denotes with
T20136 47325-47330 NN denotes Dnase
T20137 47331-47334 CC denotes and
T20138 47335-47342 VB denotes stained
T20139 47343-47347 IN denotes with
T20140 47348-47363 JJ denotes FITC-conjugated
T20141 47364-47373 JJ denotes anti-BrdU
T20142 47374-47382 NN denotes antibody
T20143 47384-47388 NN denotes Flow
T20144 47389-47398 NN denotes cytometry
T20145 47399-47402 VB denotes was
T20146 47403-47412 VB denotes performed
T20147 47413-47415 IN denotes on
T20148 47416-47427 NNP denotes FACScalibur
T20149 47428-47433 VB denotes using
T20150 47434-47437 DT denotes the
T20151 47438-47447 NN denotes CellQuest
T20152 47448-47455 NN denotes program
T20153 47456-47457 -LRB- denotes (
T20154 47457-47463 NNP denotes Becton
T20155 47464-47473 NNP denotes Dickinson
T20156 47473-47474 -RRB- denotes )
T20157 47476-47483 JJ denotes Further
T20158 47484-47492 NN denotes analysis
T20159 47493-47496 VB denotes was
T20160 47497-47506 VB denotes conducted
T20161 47507-47509 IN denotes on
T20162 47510-47513 DT denotes the
T20163 47514-47520 NNP denotes Summit
T20164 47521-47525 NN denotes v4.2
T20165 47526-47533 NN denotes program
T20166 47534-47535 -LRB- denotes (
T20167 47535-47539 NN denotes Dako
T20168 47539-47540 -RRB- denotes )
T20344 47543-47548 NN denotes Rnase
T20345 47549-47559 NN denotes protection
T20346 47560-47565 NN denotes assay
T20347 47567-47572 JJ denotes Total
T20348 47573-47576 NN denotes RNA
T20349 47577-47580 VB denotes was
T20350 47581-47589 VB denotes isolated
T20351 47590-47594 IN denotes from
T20352 47595-47600 JJ denotes CD19+
T20353 47601-47614 JJ denotes MACS-purified
T20354 47615-47616 NN denotes B
T20355 47617-47622 NN denotes cells
T20356 47623-47628 VB denotes using
T20357 47629-47632 DT denotes the
T20358 47633-47639 NNP denotes Rneasy
T20359 47640-47644 NN denotes midi
T20360 47645-47657 NN denotes purification
T20361 47658-47661 NN denotes kit
T20362 47662-47666 IN denotes with
T20363 47667-47672 NN denotes Dnase
T20364 47673-47682 NN denotes treatment
T20365 47682-47683 -COMMA- denotes ,
T20366 47684-47693 VB denotes according
T20367 47694-47696 TO denotes to
T20368 47697-47700 DT denotes the
T20369 47701-47713 NN denotes manufacturer
T20370 47713-47715 POS denotes 's
T20371 47716-47728 NN denotes instructions
T20372 47729-47730 -LRB- denotes (
T20373 47730-47736 NN denotes Qiagen
T20374 47736-47737 -RRB- denotes )
T20375 47739-47742 DT denotes The
T20376 47743-47748 NN denotes mCK-1
T20377 47749-47754 NN denotes probe
T20378 47755-47763 NN denotes template
T20379 47764-47767 NN denotes set
T20380 47768-47769 -LRB- denotes (
T20381 47769-47771 NN denotes BD
T20382 47772-47783 NNP denotes Biosciences
T20383 47783-47784 -RRB- denotes )
T20384 47785-47788 VB denotes was
T20385 47789-47796 VB denotes labeled
T20386 47797-47802 VB denotes using
T20387 47803-47806 DT denotes the
T20388 47807-47809 FW denotes In
T20389 47810-47815 FW denotes Vitro
T20390 47816-47829 NN denotes Transcription
T20391 47830-47833 NN denotes Kit
T20392 47834-47843 VB denotes according
T20393 47844-47846 TO denotes to
T20394 47847-47850 DT denotes the
T20395 47851-47863 NN denotes manufacturer
T20396 47863-47865 POS denotes 's
T20397 47866-47878 NN denotes instructions
T20398 47879-47880 -LRB- denotes (
T20399 47880-47882 NN denotes BD
T20400 47883-47894 NNP denotes Biosciences
T20401 47894-47895 -RRB- denotes )
T20402 47897-47904 RB denotes Briefly
T20403 47904-47905 -COMMA- denotes ,
T20404 47906-47908 CD denotes 50
T20405 47909-47911 NN denotes ng
T20406 47912-47914 IN denotes of
T20407 47915-47920 NN denotes mCK-1
T20408 47921-47926 NN denotes probe
T20409 47927-47930 NN denotes set
T20410 47931-47934 VB denotes was
T20411 47935-47942 VB denotes labeled
T20412 47943-47947 IN denotes with
T20413 47948-47949 -LRB- denotes [
T20414 47949-47954 NN denotes α-32P
T20415 47954-47955 -RRB- denotes ]
T20416 47955-47958 NN denotes UTP
T20417 47959-47964 VB denotes using
T20418 47965-47967 NN denotes T7
T20419 47968-47971 NN denotes RNA
T20420 47972-47982 NN denotes polymerase
T20421 47983-47986 CC denotes and
T20422 47987-47995 VB denotes purified
T20423 47996-48001 VB denotes using
T20424 48002-48010 NN denotes Sephadex
T20425 48011-48015 NN denotes G-50
T20426 48016-48023 NN denotes columns
T20427 48024-48025 -LRB- denotes (
T20428 48025-48032 NNP denotes NucAway
T20429 48033-48037 NNP denotes Spin
T20430 48038-48044 NN denotes column
T20431 48044-48045 -COMMA- denotes ,
T20432 48046-48052 NNP denotes Ambion
T20433 48052-48053 -RRB- denotes )
T20434 48055-48058 DT denotes The
T20435 48059-48066 VB denotes labeled
T20436 48067-48072 NN denotes probe
T20437 48073-48076 VB denotes was
T20438 48077-48088 VB denotes quantitated
T20439 48089-48094 VB denotes using
T20440 48095-48096 DT denotes a
T20441 48097-48110 NN denotes scintillation
T20442 48111-48118 NN denotes counter
T20443 48118-48119 -COMMA- denotes ,
T20444 48120-48123 CC denotes and
T20445 48124-48125 CD denotes 6
T20446 48126-48127 SYM denotes ×
T20447 48128-48131 CD denotes 105
T20448 48132-48141 NN denotes cherenkov
T20449 48142-48145 NN denotes cpm
T20450 48146-48149 VB denotes was
T20451 48150-48154 VB denotes used
T20452 48155-48157 TO denotes to
T20453 48158-48167 VB denotes hybridize
T20454 48168-48170 TO denotes to
T20455 48171-48172 CD denotes 4
T20456 48173-48175 NN denotes μg
T20457 48176-48178 IN denotes of
T20458 48179-48184 JJ denotes total
T20459 48185-48188 NN denotes RNA
T20460 48189-48194 VB denotes using
T20461 48195-48198 DT denotes the
T20462 48199-48202 NN denotes RPA
T20463 48203-48206 NN denotes kit
T20464 48207-48208 -LRB- denotes (
T20465 48208-48210 NN denotes BD
T20466 48211-48222 NNP denotes Biosciences
T20467 48222-48223 -RRB- denotes )
T20468 48225-48232 NN denotes Samples
T20469 48233-48237 VB denotes were
T20470 48238-48247 VB denotes denatured
T20471 48248-48250 IN denotes at
T20472 48251-48253 CD denotes 90
T20473 48254-48256 NN denotes °C
T20474 48257-48260 CC denotes and
T20475 48261-48271 VB denotes hybridized
T20476 48272-48274 IN denotes at
T20477 48275-48277 CD denotes 56
T20478 48278-48280 NN denotes °C
T20479 48281-48290 RB denotes overnight
T20480 48292-48307 JJ denotes Single-stranded
T20481 48308-48311 NN denotes RNA
T20482 48312-48315 VB denotes was
T20483 48316-48324 VB denotes digested
T20484 48325-48329 IN denotes with
T20485 48330-48331 DT denotes a
T20486 48332-48339 NN denotes mixture
T20487 48340-48342 IN denotes of
T20488 48343-48348 NN denotes Rnase
T20489 48349-48350 NN denotes A
T20490 48351-48354 CC denotes and
T20491 48355-48357 NN denotes T1
T20492 48357-48358 -COMMA- denotes ,
T20493 48359-48362 CC denotes and
T20494 48363-48375 VB denotes precipitated
T20495 48376-48381 VB denotes using
T20496 48382-48393 NN denotes isopropanol
T20497 48395-48404 VB denotes Protected
T20498 48405-48411 NN denotes probes
T20499 48412-48416 VB denotes were
T20500 48417-48425 VB denotes resolved
T20501 48426-48428 IN denotes on
T20502 48429-48430 DT denotes a
T20503 48431-48441 VB denotes denaturing
T20504 48442-48446 CD denotes 4.75
T20505 48446-48447 NN denotes %
T20506 48448-48458 NN denotes acrylamide
T20507 48459-48462 NN denotes gel
T20508 48462-48463 -COMMA- denotes ,
T20509 48464-48469 VB denotes dried
T20510 48469-48470 -COMMA- denotes ,
T20511 48471-48474 CC denotes and
T20512 48475-48481 VB denotes imaged
T20513 48482-48487 VB denotes using
T20514 48488-48489 DT denotes a
T20515 48490-48504 NN denotes phosphorImager
T20516 48505-48506 -LRB- denotes (
T20517 48506-48515 NNP denotes Molecular
T20518 48516-48524 NNP denotes Dynamics
T20519 48524-48525 -RRB- denotes )
T20520 48527-48539 NN denotes Densitometry
T20521 48540-48543 VB denotes was
T20522 48544-48553 VB denotes performed
T20523 48554-48559 VB denotes using
T20524 48560-48563 DT denotes the
T20525 48564-48574 JJ denotes ImageQuant
T20526 48575-48577 NN denotes TL
T20527 48578-48583 NN denotes v2005
T20528 48584-48592 NN denotes software
T20529 48593-48594 -LRB- denotes (
T20530 48594-48596 NNP denotes GE
T20531 48597-48607 NNP denotes Healthcare
T20532 48607-48608 -RRB- denotes )
T20773 48611-48614 NN denotes PCR
T20774 48615-48623 NN denotes analysis
T20775 48624-48626 IN denotes of
T20776 48627-48628 NN denotes κ
T20777 48629-48634 NN denotes chain
T20778 48635-48648 NN denotes rearrangement
T20779 48650-48653 NN denotes DNA
T20780 48654-48657 VB denotes was
T20781 48658-48666 VB denotes isolated
T20782 48667-48671 IN denotes from
T20783 48672-48683 NN denotes splenocytes
T20784 48684-48689 VB denotes using
T20785 48690-48693 DT denotes the
T20786 48694-48700 NNP denotes Dneasy
T20787 48701-48707 NN denotes Tissue
T20788 48708-48711 NN denotes Kit
T20789 48712-48713 -LRB- denotes (
T20790 48713-48719 NN denotes Qiagen
T20791 48719-48720 -RRB- denotes )
T20792 48720-48721 -COMMA- denotes ,
T20793 48722-48726 IN denotes with
T20794 48727-48732 NN denotes Rnase
T20795 48733-48742 NN denotes treatment
T20796 48744-48747 NN denotes PCR
T20797 48748-48757 NN denotes reactions
T20798 48758-48767 VB denotes contained
T20799 48768-48771 CD denotes 100
T20800 48772-48774 NN denotes ng
T20801 48775-48777 IN denotes of
T20802 48778-48785 JJ denotes genomic
T20803 48786-48789 NN denotes DNA
T20804 48789-48790 -COMMA- denotes ,
T20805 48791-48794 CD denotes 0.2
T20806 48795-48797 NN denotes μM
T20807 48798-48802 DT denotes each
T20808 48803-48809 NN denotes primer
T20809 48809-48810 -COMMA- denotes ,
T20810 48811-48814 CD denotes 0.2
T20811 48815-48817 NN denotes mM
T20812 48818-48823 NN denotes dNTPs
T20813 48823-48824 -COMMA- denotes ,
T20814 48825-48828 CC denotes and
T20815 48829-48832 CD denotes 2.5
T20816 48833-48834 NN denotes U
T20817 48835-48838 NN denotes Taq
T20818 48839-48842 NN denotes DNA
T20819 48843-48853 NN denotes polymerase
T20820 48854-48855 -LRB- denotes (
T20821 48855-48858 NN denotes NEB
T20822 48858-48859 -RRB- denotes )
T20823 48860-48869 VB denotes performed
T20824 48870-48872 IN denotes in
T20825 48873-48875 NN denotes 1X
T20826 48876-48885 NN denotes ThermoPol
T20827 48886-48892 NN denotes buffer
T20828 48893-48894 -LRB- denotes (
T20829 48894-48897 NN denotes NEB
T20830 48897-48898 -RRB- denotes )
T20831 48900-48907 NN denotes Primers
T20832 48908-48912 VB denotes used
T20833 48913-48917 VB denotes were
T20834 48918-48923 NNP denotes Vκcon
T20835 48924-48927 CC denotes and
T20836 48928-48934 NN denotes Jκ5–1°
T20837 48935-48938 CC denotes and
T20838 48939-48943 VB denotes have
T20839 48944-48948 VB denotes been
T20840 48949-48958 VB denotes described
T20841 48959-48969 RB denotes previously
T20842 48970-48971 -LRB- denotes [
T20843 48971-48973 CD denotes 74
T20844 48973-48974 -RRB- denotes ]
T20845 48976-48979 NN denotes PCR
T20846 48980-48990 NN denotes conditions
T21034 49120-49130 NN denotes Immunoblot
T21035 49131-49139 NN denotes analysis
T21036 49141-49146 JJ denotes Whole
T21037 49147-49151 NN denotes cell
T21038 49152-49159 NN denotes lysates
T21039 49160-49164 VB denotes were
T21040 49165-49173 VB denotes prepared
T21041 49174-49176 IN denotes in
T21042 49177-49201 NN denotes radioimmunoprecipitation
T21043 49202-49207 NN denotes assay
T21044 49208-49209 -LRB- denotes (
T21045 49209-49213 NN denotes RIPA
T21046 49213-49214 -RRB- denotes )
T21047 49215-49221 NN denotes buffer
T21048 49222-49223 -LRB- denotes (
T21049 49223-49225 CD denotes 20
T21050 49226-49228 NN denotes mM
T21051 49229-49237 NN denotes Tris-HCl
T21052 49238-49239 -LRB- denotes [
T21053 49239-49241 NN denotes pH
T21054 49242-49245 CD denotes 7.5
T21055 49245-49246 -RRB- denotes ]
T21056 49246-49247 -COMMA- denotes ,
T21057 49248-49251 CD denotes 150
T21058 49252-49254 NN denotes mM
T21059 49255-49259 NN denotes NaCl
T21060 49259-49260 -COMMA- denotes ,
T21061 49261-49262 CD denotes 1
T21062 49263-49265 NN denotes mM
T21063 49266-49270 NN denotes EDTA
T21064 49270-49271 -COMMA- denotes ,
T21065 49272-49273 CD denotes 1
T21066 49273-49274 NN denotes %
T21067 49275-49280 NN denotes NP-40
T21068 49280-49281 -COMMA- denotes ,
T21069 49282-49285 CD denotes 0.1
T21070 49285-49286 NN denotes %
T21071 49287-49290 NN denotes SDS
T21072 49290-49291 -COMMA- denotes ,
T21073 49292-49295 CD denotes 0.1
T21074 49295-49296 NN denotes %
T21075 49297-49303 NN denotes sodium
T21076 49304-49316 NN denotes deoxycholate
T21077 49316-49317 -RRB- denotes )
T21078 49318-49330 VB denotes supplemented
T21079 49331-49335 IN denotes with
T21080 49336-49337 CD denotes 2
T21081 49338-49340 NN denotes mM
T21082 49341-49361 NN denotes phenylmethylsulfonyl
T21083 49362-49370 NN denotes fluoride
T21084 49370-49371 -COMMA- denotes ,
T21085 49372-49373 CD denotes 1
T21086 49374-49376 NN denotes mM
T21087 49377-49383 NN denotes Na3VO4
T21088 49383-49384 -COMMA- denotes ,
T21089 49385-49388 CC denotes and
T21090 49389-49390 CD denotes 1
T21091 49390-49391 SYM denotes :
T21092 49391-49394 CD denotes 100
T21093 49395-49415 NN denotes protease/phosphatase
T21094 49416-49425 NN denotes inhibitor
T21095 49426-49435 NN denotes cocktails
T21096 49436-49437 -LRB- denotes (
T21097 49437-49442 NNP denotes Sigma
T21098 49442-49443 -RRB- denotes )
T21099 49445-49450 JJ denotes Crude
T21100 49451-49458 NN denotes lysates
T21101 49459-49463 VB denotes were
T21102 49464-49475 VB denotes centrifuged
T21103 49476-49478 IN denotes at
T21104 49479-49485 CD denotes 13,000
T21105 49486-49489 NN denotes rpm
T21106 49490-49493 IN denotes for
T21107 49494-49496 CD denotes 10
T21108 49497-49500 NN denotes min
T21109 49501-49503 IN denotes at
T21110 49504-49505 CD denotes 4
T21111 49506-49508 NN denotes °C
T21112 49509-49512 CC denotes and
T21113 49513-49516 DT denotes the
T21114 49517-49529 NN denotes supernatants
T21115 49530-49534 VB denotes were
T21116 49535-49544 VB denotes collected
T21117 49545-49548 IN denotes for
T21118 49549-49556 JJ denotes further
T21119 49557-49565 NN denotes analysis
T21120 49567-49574 NN denotes Protein
T21121 49575-49589 NN denotes concentrations
T21122 49590-49594 VB denotes were
T21123 49595-49605 VB denotes determined
T21124 49606-49610 IN denotes with
T21125 49611-49614 DT denotes the
T21126 49615-49622 JJ denotes Bio-Rad
T21127 49623-49625 NN denotes DC
T21128 49626-49633 NN denotes protein
T21129 49634-49639 NN denotes assay
T21130 49640-49646 NN denotes system
T21131 49648-49655 NN denotes Lysates
T21132 49656-49660 VB denotes were
T21133 49661-49667 VB denotes boiled
T21134 49668-49670 IN denotes in
T21135 49671-49674 DT denotes the
T21136 49675-49683 NN denotes presence
T21137 49684-49686 IN denotes of
T21138 49687-49690 CD denotes 2.5
T21139 49690-49691 NN denotes %
T21140 49692-49708 NN denotes β-mecaptoethanol
T21141 49708-49709 -COMMA- denotes ,
T21142 49710-49719 VB denotes separated
T21143 49720-49722 IN denotes by
T21144 49723-49733 VB denotes denaturing
T21145 49734-49742 NN denotes SDS-PAGE
T21146 49742-49743 -COMMA- denotes ,
T21147 49744-49747 CC denotes and
T21148 49748-49759 VB denotes transferred
T21149 49760-49762 TO denotes to
T21150 49763-49770 JJ denotes 0.45-μm
T21151 49771-49779 NN denotes Optitran
T21152 49780-49789 NN denotes membranes
T21153 49790-49791 -LRB- denotes (
T21154 49791-49801 NNP denotes Schleicher
T21155 49802-49803 CC denotes &
T21156 49804-49811 NNP denotes Schuell
T21157 49811-49812 -RRB- denotes )
T21158 49813-49815 IN denotes in
T21159 49816-49817 DT denotes a
T21160 49818-49825 JJ denotes Bio-Rad
T21161 49826-49834 NN denotes transfer
T21162 49835-49839 NN denotes unit
T21163 49841-49850 NN denotes Membranes
T21164 49851-49855 VB denotes were
T21165 49856-49869 VB denotes immunoblotted
T21166 49870-49874 IN denotes with
T21167 49875-49878 DT denotes the
T21168 49879-49890 JJ denotes appropriate
T21169 49891-49898 JJ denotes primary
T21170 49899-49907 NN denotes antibody
T21171 49908-49916 VB denotes followed
T21172 49917-49919 IN denotes by
T21173 49920-49931 NN denotes horseradish
T21174 49932-49949 VB denotes peroxidase–tagged
T21175 49950-49959 JJ denotes secondary
T21176 49960-49970 NN denotes antibodies
T21177 49971-49972 -LRB- denotes (
T21178 49972-49980 NNP denotes Amersham
T21179 49981-49992 NNP denotes Biosciences
T21180 49993-49996 CC denotes and
T21181 49997-50001 NNP denotes Dako
T21182 50001-50002 -RRB- denotes )
T21183 50003-50006 CC denotes and
T21184 50007-50015 VB denotes detected
T21185 50016-50020 IN denotes with
T21186 50021-50024 DT denotes the
T21187 50025-50036 NNP denotes SuperSignal
T21188 50037-50041 NNP denotes West
T21189 50042-50046 NNP denotes Pico
T21190 50047-50053 NNP denotes System
T21191 50054-50055 -LRB- denotes (
T21192 50055-50061 NNP denotes Pierce
T21193 50061-50062 -RRB- denotes )
T21924 8478-8482 JJ denotes High
T21925 8483-8487 NN denotes LMP1
T21926 8488-8498 NN denotes Expression
T21927 8499-8509 VB denotes Correlates
T21928 8510-8514 IN denotes with
T21929 8515-8518 DT denotes the
T21930 8519-8530 NN denotes Development
T21931 8531-8533 IN denotes of
T21932 8534-8542 NN denotes Lymphoma
T21933 8543-8547 NN denotes LMP1
T21934 8548-8558 NN denotes expression
T21935 8559-8561 VB denotes is
T21936 8562-8567 VB denotes shown
T21937 8568-8570 IN denotes by
T21938 8571-8572 -LRB- denotes (
T21939 8572-8573 NN denotes A
T21940 8573-8574 -RRB- denotes )
T21941 8575-8589 NN denotes immunoblotting
T21942 8590-8592 IN denotes of
T21943 8593-8601 VB denotes purified
T21944 8602-8603 NN denotes B
T21945 8604-8609 NN denotes cells
T21946 8610-8611 -LRB- denotes (
T21947 8611-8616 JJ denotes CD19+
T21948 8616-8617 -RRB- denotes )
T21949 8618-8621 CC denotes and
T21950 8622-8623 -LRB- denotes (
T21951 8623-8624 NN denotes B
T21952 8624-8625 -RRB- denotes )
T21953 8626-8646 NN denotes immunohistochemistry
T21954 8647-8655 NN denotes staining
T21955 8656-8658 IN denotes of
T21956 8659-8665 NN denotes spleen
T21957 8666-8672 NN denotes tissue
T21958 8673-8677 IN denotes from
T21959 8678-8687 JJ denotes wild-type
T21960 8688-8689 -LRB- denotes (
T21961 8689-8691 NN denotes WT
T21962 8691-8692 -RRB- denotes )
T21963 8693-8696 CC denotes and
T21964 8697-8701 NN denotes LMP1
T21965 8702-8712 JJ denotes transgenic
T21966 8713-8717 NN denotes mice
T21967 8719-8720 -LRB- denotes (
T21968 8720-8721 NN denotes A
T21969 8721-8722 -RRB- denotes )
T21970 8723-8732 NN denotes Lymphomas
T21971 8733-8736 VB denotes are
T21972 8737-8747 VB denotes identified
T21973 8748-8752 IN denotes with
T21974 8753-8754 DT denotes a
T21975 8755-8761 NN denotes number
T21976 8762-8763 -LRB- denotes (
T21977 8763-8766 CD denotes 1–7
T21978 8766-8767 -RRB- denotes )
T21979 8769-8775 NN denotes Arrows
T21980 8776-8784 VB denotes indicate
T21981 8785-8788 DT denotes the
T21982 8789-8802 JJ denotes LMP1-specific
T21983 8803-8807 NN denotes band
T21984 8808-8811 CC denotes and
T21985 8812-8815 PRP-DOLLAR- denotes its
T21986 8816-8827 NN denotes degradation
T21987 8828-8836 NN denotes products
T21988 8837-8839 RB denotes as
T21989 8840-8844 RB denotes well
T21990 8845-8847 IN denotes as
T21991 8848-8849 DT denotes a
T21992 8850-8862 JJ denotes non-specific
T21993 8863-8867 NN denotes band
T21994 8869-8874 NN denotes Actin
T21995 8875-8878 VB denotes was
T21996 8879-8883 VB denotes used
T21997 8884-8886 IN denotes as
T21998 8887-8888 DT denotes a
T21999 8889-8896 NN denotes loading
T22000 8897-8904 NN denotes control
T22001 8906-8907 -LRB- denotes (
T22002 8907-8908 NN denotes B
T22003 8908-8909 -RRB- denotes )
T22004 8910-8915 JJ denotes White
T22005 8916-8919 CC denotes and
T22006 8920-8923 JJ denotes red
T22007 8924-8929 NN denotes pulps
T22008 8930-8933 VB denotes are
T22009 8934-8939 VB denotes shown
T22010 8939-8940 -COMMA- denotes ,
T22011 8941-8944 CC denotes but
T22012 8945-8949 DT denotes this
T22013 8950-8962 NN denotes architecture
T22014 8963-8965 VB denotes is
T22015 8966-8970 VB denotes lost
T22016 8971-8975 IN denotes upon
T22017 8976-8987 NN denotes development
T22018 8988-8990 IN denotes of
T22019 8991-8999 NN denotes lymphoma
T22020 9001-9006 NN denotes Scale
T22021 9007-9010 NN denotes bar
T22022 9010-9011 -COMMA- denotes ,
T22023 9012-9014 CD denotes 20
T22024 9015-9017 NN denotes μm
T22122 10554-10558 NN denotes LMP1
T22123 10559-10567 VB denotes Promotes
T22124 10568-10572 NN denotes B-1a
T22125 10573-10582 NN denotes Lymphomas
T22126 10583-10587 WDT denotes That
T22127 10588-10591 MD denotes Can
T22128 10592-10598 NNP denotes Escape
T22129 10599-10606 NNP denotes Allelic
T22130 10607-10616 NNP denotes Exclusion
T22131 10617-10618 -LRB- denotes (
T22132 10618-10619 NN denotes A
T22133 10619-10620 -RRB- denotes )
T22134 10621-10625 NN denotes Flow
T22135 10626-10635 NN denotes cytometry
T22136 10636-10644 NN denotes analysis
T22137 10645-10647 IN denotes of
T22138 10648-10659 NN denotes splenocytes
T22139 10660-10664 IN denotes from
T22140 10665-10666 DT denotes a
T22141 10667-10669 NN denotes WT
T22142 10670-10672 CC denotes or
T22143 10673-10677 NN denotes LMP1
T22144 10678-10688 JJ denotes transgenic
T22145 10689-10697 NN denotes lymphoma
T22146 10698-10701 IN denotes for
T22147 10702-10705 DT denotes the
T22148 10706-10711 NN denotes pan–B
T22149 10712-10716 NN denotes cell
T22150 10717-10718 -LRB- denotes (
T22151 10718-10722 NN denotes CD19
T22152 10722-10723 -RRB- denotes )
T22153 10723-10724 -COMMA- denotes ,
T22154 10725-10729 NN denotes B-1a
T22155 10730-10734 NN denotes cell
T22156 10735-10736 -LRB- denotes (
T22157 10736-10739 NN denotes CD5
T22158 10739-10740 -RRB- denotes )
T22159 10740-10741 -COMMA- denotes ,
T22160 10742-10745 CC denotes and
T22161 10746-10748 NN denotes Ig
T22162 10749-10754 JJ denotes heavy
T22163 10755-10760 NN denotes chain
T22164 10761-10762 -LRB- denotes (
T22165 10762-10765 NN denotes IgM
T22166 10766-10769 CC denotes and
T22167 10770-10773 NN denotes IgD
T22168 10773-10774 -RRB- denotes )
T22169 10775-10778 CC denotes and
T22170 10779-10784 JJ denotes light
T22171 10785-10790 NN denotes chain
T22172 10791-10792 -LRB- denotes (
T22173 10792-10793 NN denotes κ
T22174 10794-10797 CC denotes and
T22175 10798-10799 LS denotes λ
T22176 10799-10800 -RRB- denotes )
T22177 10801-10808 NN denotes markers
T22178 10810-10815 VB denotes Shown
T22179 10816-10819 VB denotes are
T22180 10820-10823 DT denotes the
T22181 10824-10831 NN denotes results
T22182 10832-10836 IN denotes from
T22183 10837-10839 JJ denotes WT
T22184 10840-10848 NN denotes lymphoma
T22185 10849-10850 CD denotes 1
T22186 10851-10854 CC denotes and
T22187 10855-10859 NN denotes LMP1
T22188 10860-10870 JJ denotes transgenic
T22189 10871-10879 NN denotes lymphoma
T22190 10880-10881 CD denotes 4
T22191 10883-10887 DT denotes This
T22192 10888-10896 NN denotes analysis
T22193 10897-10900 VB denotes was
T22194 10901-10909 VB denotes repeated
T22195 10910-10912 IN denotes on
T22196 10913-10917 CD denotes four
T22197 10918-10923 JJ denotes other
T22198 10924-10928 NN denotes LMP1
T22199 10929-10939 JJ denotes transgenic
T22200 10940-10949 NN denotes lymphomas
T22201 10950-10951 -LRB- denotes (
T22202 10951-10952 CD denotes 1
T22203 10952-10953 -COMMA- denotes ,
T22204 10954-10955 CD denotes 2
T22205 10955-10956 -COMMA- denotes ,
T22206 10957-10958 CD denotes 3
T22207 10958-10959 -COMMA- denotes ,
T22208 10960-10963 CC denotes and
T22209 10964-10965 CD denotes 6
T22210 10965-10966 -RRB- denotes )
T22211 10967-10974 VB denotes showing
T22212 10975-10976 DT denotes a
T22213 10977-10984 JJ denotes similar
T22214 10985-10989 NN denotes B-1a
T22215 10990-10999 NN denotes phenotype
T22216 10999-11000 -COMMA- denotes ,
T22217 11001-11003 IN denotes of
T22218 11004-11009 WDT denotes which
T22219 11010-11019 NN denotes lymphomas
T22220 11020-11021 CD denotes 2
T22221 11022-11025 CC denotes and
T22222 11026-11027 CD denotes 4
T22223 11028-11032 VB denotes were
T22224 11033-11037 RB denotes also
T22225 11038-11044 RB denotes doubly
T22226 11045-11053 JJ denotes positive
T22227 11054-11057 IN denotes for
T22228 11058-11059 NN denotes κ
T22229 11060-11063 CC denotes and
T22230 11064-11065 VB denotes λ
T22231 11066-11071 JJ denotes light
T22232 11072-11078 NN denotes chains
T22233 11080-11081 -LRB- denotes (
T22234 11081-11082 NN denotes B
T22235 11082-11083 -RRB- denotes )
T22236 11084-11088 NN denotes Flow
T22237 11089-11098 NN denotes cytometry
T22238 11099-11107 NN denotes analysis
T22239 11108-11110 IN denotes of
T22240 11111-11113 NN denotes WT
T22241 11114-11116 CC denotes or
T22242 11117-11121 NN denotes LMP1
T22243 11122-11132 JJ denotes transgenic
T22244 11133-11144 NN denotes splenocytes
T22245 11145-11148 IN denotes for
T22246 11149-11153 NN denotes B-1a
T22247 11154-11155 -LRB- denotes (
T22248 11155-11164 JJ denotes CD19+CD5+
T22249 11164-11165 -RRB- denotes )
T22250 11166-11169 CC denotes and
T22251 11170-11174 NN denotes B-1b
T22252 11175-11177 CC denotes or
T22253 11178-11180 NN denotes B2
T22254 11181-11188 NN denotes subsets
T22255 11189-11190 -LRB- denotes (
T22256 11190-11199 NN denotes CD19+CD5−
T22257 11199-11200 -RRB- denotes )
T22258 11202-11213 NN denotes Percentages
T22259 11214-11216 IN denotes of
T22260 11217-11221 NN denotes B-1a
T22261 11222-11225 CC denotes and
T22262 11226-11230 NN denotes B-1b
T22263 11231-11233 CC denotes or
T22264 11234-11236 NN denotes B2
T22265 11237-11244 NN denotes subsets
T22266 11245-11248 VB denotes are
T22267 11249-11254 VB denotes shown
T22268 11255-11257 IN denotes in
T22269 11258-11262 DT denotes each
T22270 11263-11271 NN denotes quadrant
T22271 11273-11277 DT denotes This
T22272 11278-11286 NN denotes analysis
T22273 11287-11290 VB denotes was
T22274 11291-11299 VB denotes repeated
T22275 11300-11302 IN denotes on
T22276 11303-11308 CD denotes three
T22277 11309-11314 JJ denotes other
T22278 11315-11317 NN denotes WT
T22279 11318-11321 CC denotes and
T22280 11322-11325 CD denotes two
T22281 11326-11331 JJ denotes other
T22282 11332-11336 NN denotes LMP1
T22283 11337-11347 JJ denotes transgenic
T22284 11348-11352 NN denotes mice
T22285 11353-11357 IN denotes with
T22286 11358-11365 JJ denotes similar
T22287 11366-11373 NN denotes results
T22288 11375-11376 -LRB- denotes (
T22289 11376-11377 NN denotes C
T22290 11377-11378 -RRB- denotes )
T22291 11379-11389 NN denotes Immunoblot
T22292 11390-11398 NN denotes analysis
T22293 11399-11402 IN denotes for
T22294 11403-11404 NN denotes κ
T22295 11405-11408 CC denotes and
T22296 11409-11410 VB denotes λ
T22297 11411-11416 JJ denotes light
T22298 11417-11423 NN denotes chains
T22299 11424-11426 IN denotes of
T22300 11427-11428 NN denotes B
T22301 11429-11434 NN denotes cells
T22302 11435-11436 -LRB- denotes (
T22303 11436-11441 JJ denotes CD19+
T22304 11441-11442 -RRB- denotes )
T22305 11443-11451 VB denotes purified
T22306 11452-11456 IN denotes from
T22307 11457-11459 NN denotes WT
T22308 11460-11463 CC denotes and
T22309 11464-11468 NN denotes LMP1
T22310 11469-11479 JJ denotes transgenic
T22311 11480-11484 NN denotes mice
T22312 11486-11491 NN denotes Actin
T22313 11492-11495 VB denotes was
T22314 11496-11500 VB denotes used
T22315 11501-11503 IN denotes as
T22316 11504-11505 DT denotes a
T22317 11506-11513 NN denotes loading
T22318 11514-11521 NN denotes control
T22664 14367-14371 NN denotes LMP1
T22665 14372-14380 VB denotes Promotes
T22666 14381-14382 NN denotes B
T22667 14383-14387 NN denotes Cell
T22668 14388-14396 NN denotes Survival
T22669 14397-14400 CC denotes and
T22670 14401-14414 NN denotes Proliferation
T22671 14415-14417 IN denotes In
T22672 14418-14423 NNP denotes Vitro
T22673 14424-14425 -LRB- denotes (
T22674 14425-14426 NN denotes A
T22675 14426-14427 -RRB- denotes )
T22676 14428-14431 NN denotes MTS
T22677 14432-14437 NN denotes assay
T22678 14438-14440 IN denotes of
T22679 14441-14452 NN denotes splenocytes
T22680 14453-14457 IN denotes from
T22681 14458-14460 NN denotes WT
T22682 14461-14464 CC denotes and
T22683 14465-14469 NN denotes LMP1
T22684 14470-14480 JJ denotes transgenic
T22685 14481-14485 NN denotes mice
T22686 14487-14498 NN denotes Splenocytes
T22687 14499-14503 VB denotes were
T22688 14504-14512 VB denotes cultured
T22689 14513-14515 IN denotes in
T22690 14516-14519 DT denotes the
T22691 14520-14528 NN denotes presence
T22692 14529-14530 -LRB- denotes (
T22693 14530-14534 JJ denotes grey
T22694 14535-14539 NN denotes bars
T22695 14539-14540 -RRB- denotes )
T22696 14541-14543 CC denotes or
T22697 14544-14551 NN denotes absence
T22698 14552-14553 -LRB- denotes (
T22699 14553-14558 JJ denotes black
T22700 14559-14563 NN denotes bars
T22701 14563-14564 -RRB- denotes )
T22702 14565-14567 IN denotes of
T22703 14568-14571 NN denotes IL4
T22704 14572-14575 IN denotes for
T22705 14576-14577 CD denotes 3
T22706 14578-14579 NN denotes d
T22707 14581-14584 DT denotes The
T22708 14585-14592 NN denotes results
T22709 14593-14596 VB denotes are
T22710 14597-14600 DT denotes the
T22711 14601-14605 JJ denotes mean
T22712 14606-14607 JJ denotes ±
T22713 14608-14611 NN denotes SEM
T22714 14612-14614 IN denotes of
T22715 14615-14625 JJ denotes triplicate
T22716 14626-14633 NN denotes samples
T22717 14634-14642 VB denotes averaged
T22718 14643-14647 IN denotes from
T22719 14648-14656 JJ denotes multiple
T22720 14657-14661 NN denotes mice
T22721 14662-14667 WRB denotes where
T22722 14668-14671 PDT denotes “n”
T22723 14672-14675 DT denotes the
T22724 14676-14682 NN denotes number
T22725 14683-14685 IN denotes of
T22726 14686-14690 NN denotes mice
T22727 14691-14699 VB denotes analyzed
T22728 14700-14702 VB denotes is
T22729 14703-14705 RB denotes as
T22730 14706-14713 VB denotes follows
T22731 14713-14714 -COLON- denotes :
T22732 14715-14716 NN denotes n
T22733 14717-14718 SYM denotes =
T22734 14719-14720 CD denotes 2
T22735 14721-14724 IN denotes for
T22736 14725-14727 JJ denotes WT
T22737 14728-14739 NN denotes lymphocytes
T22738 14740-14743 CC denotes and
T22739 14744-14746 JJ denotes WT
T22740 14747-14756 NN denotes lymphomas
T22741 14756-14757 -COMMA- denotes ,
T22742 14758-14759 NN denotes n
T22743 14760-14761 SYM denotes =
T22744 14762-14764 CD denotes 11
T22745 14765-14768 IN denotes for
T22746 14769-14773 NN denotes LMP1
T22747 14774-14784 JJ denotes transgenic
T22748 14785-14796 NN denotes lymphocytes
T22749 14796-14797 -COMMA- denotes ,
T22750 14798-14801 CC denotes and
T22751 14802-14803 NN denotes n
T22752 14804-14805 SYM denotes =
T22753 14806-14808 CD denotes 13
T22754 14809-14812 IN denotes for
T22755 14813-14817 NN denotes LMP1
T22756 14818-14828 JJ denotes transgenic
T22757 14829-14838 NN denotes lymphomas
T22758 14840-14841 -LRB- denotes (
T22759 14841-14842 NN denotes B
T22760 14842-14843 -RRB- denotes )
T22761 14844-14847 NN denotes EMA
T22762 14848-14857 NN denotes exclusion
T22763 14858-14860 IN denotes of
T22764 14861-14866 JJ denotes CD19+
T22765 14867-14872 JJ denotes gated
T22766 14873-14884 NN denotes splenocytes
T22767 14885-14889 IN denotes from
T22768 14890-14892 NN denotes WT
T22769 14893-14896 CC denotes and
T22770 14897-14901 NN denotes LMP1
T22771 14902-14912 JJ denotes transgenic
T22772 14913-14917 NN denotes mice
T22773 14918-14925 VB denotes showing
T22774 14926-14936 NN denotes percentage
T22775 14937-14939 IN denotes of
T22776 14940-14946 JJ denotes viable
T22777 14947-14948 NN denotes B
T22778 14949-14954 NN denotes cells
T22779 14955-14963 VB denotes cultured
T22780 14964-14968 IN denotes with
T22781 14969-14970 -LRB- denotes (
T22782 14970-14975 JJ denotes white
T22783 14976-14980 NN denotes bars
T22784 14980-14981 -RRB- denotes )
T22785 14982-14984 CC denotes or
T22786 14985-14992 IN denotes without
T22787 14993-14994 -LRB- denotes (
T22788 14994-14999 JJ denotes black
T22789 15000-15004 NN denotes bars
T22790 15004-15005 -RRB- denotes )
T22791 15006-15009 NN denotes IL4
T22792 15010-15013 IN denotes for
T22793 15014-15015 CD denotes 2
T22794 15016-15017 NN denotes d
T22795 15019-15020 -LRB- denotes (
T22796 15020-15021 NN denotes C
T22797 15021-15022 -RRB- denotes )
T22798 15023-15027 NN denotes Flow
T22799 15028-15037 NN denotes cytometry
T22800 15038-15046 NN denotes analysis
T22801 15047-15050 IN denotes for
T22802 15051-15063 JJ denotes incorporated
T22803 15064-15068 NNP denotes BrdU
T22804 15069-15071 IN denotes in
T22805 15072-15074 NN denotes WT
T22806 15075-15078 CC denotes and
T22807 15079-15083 NN denotes LMP1
T22808 15084-15094 JJ denotes transgenic
T22809 15095-15103 NN denotes lymphoma
T22810 15104-15109 NN denotes cells
T22811 15110-15118 VB denotes cultured
T22812 15119-15123 IN denotes with
T22813 15124-15126 CC denotes or
T22814 15127-15134 IN denotes without
T22815 15135-15138 NN denotes IL4
T22816 15139-15142 IN denotes for
T22817 15143-15144 CD denotes 2
T22818 15145-15146 NN denotes d
T22819 15148-15153 VB denotes Shown
T22820 15154-15157 VB denotes are
T22821 15158-15161 DT denotes the
T22822 15162-15169 NN denotes results
T22823 15170-15174 IN denotes from
T22824 15175-15177 JJ denotes WT
T22825 15178-15186 NN denotes lymphoma
T22826 15187-15188 CD denotes 1
T22827 15189-15192 CC denotes and
T22828 15193-15197 NN denotes LMP1
T22829 15198-15208 JJ denotes transgenic
T22830 15209-15217 NN denotes lymphoma
T22831 15218-15219 CD denotes 2
T22832 15221-15232 NN denotes Percentages
T22833 15233-15235 IN denotes of
T22834 15236-15241 NN denotes cells
T22835 15242-15244 IN denotes in
T22836 15245-15249 DT denotes each
T22837 15250-15258 NN denotes quadrant
T22838 15259-15262 VB denotes are
T22839 15263-15268 VB denotes shown
T23152 17941-17950 NN denotes Wild-Type
T23153 17951-17954 CC denotes and
T23154 17955-17959 NN denotes LMP1
T23155 17960-17970 NNP denotes Transgenic
T23156 17971-17979 NNP denotes Lymphoma
T23157 17980-17985 NNP denotes Cells
T23158 17986-17993 NNP denotes Survive
T23159 17994-18007 NNP denotes Independently
T23160 18008-18010 IN denotes of
T23161 18011-18020 NN denotes IL4/Stat6
T23162 18021-18030 NN denotes Signaling
T23163 18031-18033 IN denotes in
T23164 18034-18041 NN denotes Culture
T23165 18042-18043 -LRB- denotes (
T23166 18043-18044 NN denotes A
T23167 18044-18045 -RRB- denotes )
T23168 18046-18051 NN denotes Rnase
T23169 18052-18062 NN denotes protection
T23170 18063-18068 NN denotes assay
T23171 18069-18072 IN denotes for
T23172 18073-18076 NN denotes IL4
T23173 18077-18081 NN denotes mRNA
T23174 18082-18086 IN denotes from
T23175 18087-18095 VB denotes purified
T23176 18096-18097 NN denotes B
T23177 18098-18103 NN denotes cells
T23178 18104-18105 -LRB- denotes (
T23179 18105-18110 JJ denotes CD19+
T23180 18110-18111 -RRB- denotes )
T23181 18112-18116 IN denotes from
T23182 18117-18119 NN denotes WT
T23183 18120-18123 CC denotes and
T23184 18124-18128 NN denotes LMP1
T23185 18129-18139 JJ denotes transgenic
T23186 18140-18151 NN denotes splenocytes
T23187 18153-18156 DT denotes The
T23188 18157-18160 NN denotes L32
T23189 18161-18164 CC denotes and
T23190 18165-18170 NN denotes GAPDH
T23191 18171-18183 NN denotes housekeeping
T23192 18184-18189 NN denotes genes
T23193 18190-18194 VB denotes were
T23194 18195-18199 VB denotes used
T23195 18200-18202 IN denotes as
T23196 18203-18204 DT denotes a
T23197 18205-18212 NN denotes loading
T23198 18213-18220 NN denotes control
T23199 18222-18227 NN denotes Arrow
T23200 18228-18237 VB denotes indicates
T23201 18238-18241 DT denotes the
T23202 18242-18250 NN denotes position
T23203 18251-18253 IN denotes of
T23204 18254-18257 DT denotes the
T23205 18258-18267 JJ denotes protected
T23206 18268-18273 NN denotes probe
T23207 18275-18276 -LRB- denotes (
T23208 18276-18277 NN denotes B
T23209 18278-18281 CC denotes and
T23210 18282-18283 NN denotes C
T23211 18283-18284 -RRB- denotes )
T23212 18285-18295 NN denotes Immunoblot
T23213 18296-18304 NN denotes analysis
T23214 18305-18307 IN denotes of
T23215 18308-18310 NN denotes WT
T23216 18311-18314 CC denotes and
T23217 18315-18319 NN denotes LMP1
T23218 18320-18330 JJ denotes transgenic
T23219 18331-18335 NN denotes mice
T23220 18336-18339 IN denotes for
T23221 18340-18349 VB denotes activated
T23222 18350-18356 NN denotes pStat6
T23223 18357-18359 IN denotes in
T23224 18360-18361 -LRB- denotes (
T23225 18361-18362 NN denotes B
T23226 18362-18363 -RRB- denotes )
T23227 18364-18372 VB denotes purified
T23228 18373-18374 NN denotes B
T23229 18375-18380 NN denotes cells
T23230 18381-18382 -LRB- denotes (
T23231 18382-18387 JJ denotes CD19+
T23232 18387-18388 -RRB- denotes )
T23233 18389-18391 IN denotes at
T23234 18392-18395 DT denotes the
T23235 18396-18400 NN denotes time
T23236 18401-18403 IN denotes of
T23237 18404-18411 NN denotes harvest
T23238 18412-18414 CC denotes or
T23239 18415-18417 IN denotes in
T23240 18418-18419 -LRB- denotes (
T23241 18419-18420 NN denotes C
T23242 18420-18421 -RRB- denotes )
T23243 18422-18427 JJ denotes whole
T23244 18428-18439 NN denotes splenocytes
T23245 18440-18448 VB denotes cultured
T23246 18449-18453 IN denotes with
T23247 18454-18456 CC denotes or
T23248 18457-18464 IN denotes without
T23249 18465-18469 NN denotes IL4.
T23250 18470-18471 -LRB- denotes (
T23251 18471-18472 NN denotes B
T23252 18472-18473 -RRB- denotes )
T23253 18474-18479 NN denotes Actin
T23254 18480-18483 VB denotes was
T23255 18484-18488 VB denotes used
T23256 18489-18491 IN denotes as
T23257 18492-18493 DT denotes a
T23258 18494-18501 NN denotes loading
T23259 18502-18509 NN denotes control
T23260 18509-18510 -COMMA- denotes ,
T23261 18511-18514 CC denotes and
T23262 18515-18518 DT denotes the
T23263 18519-18524 JJ denotes white
T23264 18525-18529 NN denotes line
T23265 18530-18539 VB denotes indicates
T23266 18540-18544 IN denotes that
T23267 18545-18556 VB denotes intervening
T23268 18557-18562 NN denotes lanes
T23269 18563-18567 VB denotes have
T23270 18568-18572 VB denotes been
T23271 18573-18580 VB denotes spliced
T23272 18581-18584 RP denotes out
T23273 18586-18587 -LRB- denotes (
T23274 18587-18588 NN denotes D
T23275 18589-18592 CC denotes and
T23276 18593-18594 NN denotes E
T23277 18594-18595 -RRB- denotes )
T23278 18596-18599 NN denotes MTS
T23279 18600-18605 NN denotes assay
T23280 18606-18608 IN denotes of
T23281 18609-18610 -LRB- denotes (
T23282 18610-18611 NN denotes D
T23283 18611-18612 -RRB- denotes )
T23284 18613-18615 JJ denotes WT
T23285 18616-18627 NN denotes lymphocytes
T23286 18628-18631 CC denotes and
T23287 18632-18633 -LRB- denotes (
T23288 18633-18634 NN denotes E
T23289 18634-18635 -RRB- denotes )
T23290 18636-18640 NN denotes LMP1
T23291 18641-18651 JJ denotes transgenic
T23292 18652-18660 NN denotes lymphoma
T23293 18661-18666 NN denotes cells
T23294 18667-18675 VB denotes cultured
T23295 18676-18680 IN denotes with
T23296 18681-18684 NN denotes IL4
T23297 18684-18685 -COMMA- denotes ,
T23298 18686-18687 DT denotes a
T23299 18688-18700 VB denotes neutralizing
T23300 18701-18709 NN denotes antibody
T23301 18710-18712 TO denotes to
T23302 18713-18716 NN denotes IL4
T23303 18716-18717 -COMMA- denotes ,
T23304 18718-18720 CC denotes or
T23305 18721-18722 DT denotes a
T23306 18723-18726 NN denotes rat
T23307 18727-18730 NN denotes IgG
T23308 18731-18738 NN denotes isotype
T23309 18739-18746 NN denotes control
T23310 18747-18749 IN denotes at
T23311 18750-18753 DT denotes the
T23312 18754-18763 VB denotes indicated
T23313 18764-18778 NN denotes concentrations
T23314 18780-18785 VB denotes Shown
T23315 18786-18789 VB denotes are
T23316 18790-18793 DT denotes the
T23317 18794-18801 NN denotes results
T23318 18802-18806 IN denotes from
T23319 18807-18811 NN denotes LMP1
T23320 18812-18822 JJ denotes transgenic
T23321 18823-18831 NN denotes lymphoma
T23322 18832-18833 CD denotes 3
T23323 18835-18838 DT denotes The
T23324 18839-18846 NN denotes results
T23325 18847-18850 VB denotes are
T23326 18851-18854 DT denotes the
T23327 18855-18859 JJ denotes mean
T23328 18860-18861 JJ denotes ±
T23329 18862-18865 NN denotes SEM
T23330 18866-18868 IN denotes of
T23331 18869-18879 JJ denotes triplicate
T23332 18880-18887 NN denotes samples
T23333 18888-18892 IN denotes from
T23334 18893-18894 DT denotes a
T23335 18895-18901 JJ denotes single
T23336 18902-18916 JJ denotes representative
T23337 18917-18927 NN denotes experiment
T23338 18928-18932 WDT denotes that
T23339 18933-18936 VB denotes was
T23340 18937-18945 VB denotes repeated
T23341 18946-18951 RB denotes twice
T23342 18952-18956 IN denotes with
T23343 18957-18964 JJ denotes similar
T23344 18965-18972 NN denotes results
T23741 22890-22894 NN denotes LMP1
T23742 22895-22906 VB denotes Upregulates
T23743 22907-22911 NN denotes IL10
T23744 22912-22922 NN denotes Expression
T23745 22923-22926 CC denotes and
T23746 22927-22941 RB denotes Constitutively
T23747 22942-22951 VB denotes Activates
T23748 22952-22957 NN denotes Stat3
T23749 22958-22959 -LRB- denotes (
T23750 22959-22960 NN denotes A
T23751 22960-22961 -RRB- denotes )
T23752 22962-22970 JJ denotes Relative
T23753 22971-22981 NN denotes expression
T23754 22982-22984 IN denotes of
T23755 22985-22989 NN denotes IL10
T23756 22989-22990 -COMMA- denotes ,
T23757 22991-22995 NN denotes IL15
T23758 22995-22996 -COMMA- denotes ,
T23759 22997-23000 CC denotes and
T23760 23001-23005 NN denotes IFNγ
T23761 23006-23010 NN denotes mRNA
T23762 23011-23013 IN denotes in
T23763 23014-23016 NN denotes WT
T23764 23017-23020 CC denotes and
T23765 23021-23025 NN denotes LMP1
T23766 23026-23036 JJ denotes transgenic
T23767 23037-23038 NN denotes B
T23768 23039-23044 NN denotes cells
T23769 23045-23046 -LRB- denotes (
T23770 23046-23051 JJ denotes CD19+
T23771 23051-23052 -RRB- denotes )
T23772 23052-23053 -COMMA- denotes ,
T23773 23054-23056 IN denotes as
T23774 23057-23065 VB denotes detected
T23775 23066-23070 IN denotes with
T23776 23071-23073 DT denotes an
T23777 23074-23079 NN denotes Rnase
T23778 23080-23090 NN denotes protection
T23779 23091-23096 NN denotes assay
T23780 23098-23103 NN denotes Mouse
T23781 23104-23112 NN denotes lymphoma
T23782 23113-23117 NN denotes cell
T23783 23118-23123 NN denotes lines
T23784 23124-23127 CD denotes 967
T23785 23128-23131 CC denotes and
T23786 23132-23136 NN denotes K46μ
T23787 23137-23141 VB denotes were
T23788 23142-23146 VB denotes used
T23789 23147-23149 IN denotes as
T23790 23150-23158 NN denotes controls
T23791 23160-23170 NN denotes Expression
T23792 23171-23177 NN denotes levels
T23793 23178-23182 VB denotes were
T23794 23183-23193 VB denotes quantified
T23795 23194-23198 IN denotes with
T23796 23199-23200 DT denotes a
T23797 23201-23215 NN denotes phosphorimager
T23798 23216-23219 CC denotes and
T23799 23220-23226 NN denotes values
T23800 23227-23231 VB denotes were
T23801 23232-23242 VB denotes normalized
T23802 23243-23245 TO denotes to
T23803 23246-23249 DT denotes the
T23804 23250-23259 JJ denotes ribosomal
T23805 23260-23272 NN denotes housekeeping
T23806 23273-23277 NN denotes gene
T23807 23278-23281 NN denotes L32
T23808 23283-23286 DT denotes The
T23809 23287-23295 NN denotes cytokine
T23810 23295-23296 -COLON- denotes :
T23811 23296-23299 NN denotes L32
T23812 23300-23305 NN denotes ratio
T23813 23306-23309 VB denotes was
T23814 23310-23313 VB denotes set
T23815 23314-23316 TO denotes to
T23816 23317-23318 CD denotes 1
T23817 23319-23321 IN denotes in
T23818 23322-23325 DT denotes the
T23819 23326-23331 NN denotes mouse
T23820 23332-23333 NN denotes B
T23821 23334-23338 NN denotes cell
T23822 23339-23347 NN denotes lymphoma
T23823 23348-23352 NN denotes line
T23824 23353-23356 CD denotes 967
T23825 23358-23359 -LRB- denotes (
T23826 23359-23360 NN denotes B
T23827 23361-23364 CC denotes and
T23828 23365-23366 NN denotes C
T23829 23366-23367 -RRB- denotes )
T23830 23368-23378 NN denotes Immunoblot
T23831 23379-23387 NN denotes analysis
T23832 23388-23390 IN denotes of
T23833 23391-23400 VB denotes activated
T23834 23401-23407 NN denotes pStat3
T23835 23408-23410 IN denotes in
T23836 23411-23419 VB denotes purified
T23837 23420-23421 NN denotes B
T23838 23422-23427 NN denotes cells
T23839 23428-23429 -LRB- denotes (
T23840 23429-23434 JJ denotes CD19+
T23841 23434-23435 -RRB- denotes )
T23842 23436-23440 IN denotes from
T23843 23441-23443 NN denotes WT
T23844 23444-23447 CC denotes and
T23845 23448-23452 NN denotes LMP1
T23846 23453-23463 JJ denotes transgenic
T23847 23464-23468 NN denotes mice
T23848 23469-23470 -LRB- denotes (
T23849 23470-23471 NN denotes B
T23850 23471-23472 -RRB- denotes )
T23851 23473-23475 IN denotes at
T23852 23476-23479 DT denotes the
T23853 23480-23484 NN denotes time
T23854 23485-23487 IN denotes of
T23855 23488-23495 NN denotes harvest
T23856 23495-23496 -COMMA- denotes ,
T23857 23497-23500 CC denotes and
T23858 23501-23502 -LRB- denotes (
T23859 23502-23503 NN denotes C
T23860 23503-23504 -RRB- denotes )
T23861 23505-23506 CD denotes 4
T23862 23507-23508 NN denotes h
T23863 23509-23514 IN denotes after
T23864 23515-23522 NN denotes culture
T23865 23523-23527 IN denotes with
T23866 23528-23530 CC denotes or
T23867 23531-23538 IN denotes without
T23868 23539-23543 NN denotes IL10
T23869 23543-23544 -COMMA- denotes ,
T23870 23545-23546 DT denotes a
T23871 23547-23559 VB denotes neutralizing
T23872 23560-23568 NN denotes antibody
T23873 23569-23571 TO denotes to
T23874 23572-23576 NN denotes IL10
T23875 23576-23577 -COMMA- denotes ,
T23876 23578-23580 CC denotes or
T23877 23581-23582 DT denotes a
T23878 23583-23586 NN denotes rat
T23879 23587-23591 NN denotes IgG1
T23880 23592-23599 NN denotes isotype
T23881 23600-23608 NN denotes control.
T23882 23609-23610 -LRB- denotes (
T23883 23610-23611 NN denotes C
T23884 23611-23612 -RRB- denotes )
T23885 23613-23618 NNP denotes Shown
T23886 23619-23622 VB denotes are
T23887 23623-23626 DT denotes the
T23888 23627-23634 NN denotes results
T23889 23635-23638 IN denotes for
T23890 23639-23641 JJ denotes WT
T23891 23642-23650 NN denotes lymphoma
T23892 23651-23652 CD denotes 1
T23893 23653-23656 CC denotes and
T23894 23657-23661 NN denotes LMP1
T23895 23662-23672 JJ denotes transgenic
T23896 23673-23681 NN denotes lymphoma
T23897 23682-23683 CD denotes 1
T23898 23685-23691 NN denotes Arrows
T23899 23692-23700 VB denotes indicate
T23900 23701-23704 DT denotes the
T23901 23705-23714 NN denotes positions
T23902 23715-23717 IN denotes of
T23903 23718-23721 DT denotes the
T23904 23722-23723 NN denotes α
T23905 23724-23727 CC denotes and
T23906 23728-23729 VB denotes β
T23907 23730-23738 NN denotes isoforms
T23908 23739-23741 IN denotes of
T23909 23742-23747 NN denotes Stat3
T23910 23749-23754 NN denotes Actin
T23911 23755-23758 VB denotes was
T23912 23759-23763 VB denotes used
T23913 23764-23766 IN denotes as
T23914 23767-23768 DT denotes a
T23915 23769-23776 NN denotes loading
T23916 23777-23784 NN denotes control
T23917 23786-23787 -LRB- denotes (
T23918 23787-23788 NN denotes D
T23919 23788-23789 -RRB- denotes )
T23920 23790-23810 NN denotes Immunohistochemistry
T23921 23811-23820 NN denotes detection
T23922 23821-23823 IN denotes of
T23923 23824-23833 VB denotes activated
T23924 23834-23841 JJ denotes nuclear
T23925 23842-23848 NN denotes pStat3
T23926 23849-23851 IN denotes in
T23927 23852-23855 DT denotes the
T23928 23856-23863 NN denotes spleens
T23929 23864-23866 IN denotes of
T23930 23867-23869 NN denotes WT
T23931 23870-23873 CC denotes and
T23932 23874-23878 NN denotes LMP1
T23933 23879-23889 JJ denotes transgenic
T23934 23890-23894 NN denotes mice
T23935 23896-23901 NN denotes Scale
T23936 23902-23905 NN denotes bar
T23937 23905-23906 -COMMA- denotes ,
T23938 23907-23909 CD denotes 20
T23939 23910-23912 NN denotes μm
T24376 25723-25727 NN denotes LMP1
T24377 25728-25737 VB denotes Activates
T24378 25738-25741 NN denotes Akt
T24379 25742-25751 NN denotes Signaling
T24380 25752-25755 CC denotes and
T24381 25756-25767 VB denotes Deregulates
T24382 25768-25771 DT denotes the
T24383 25772-25774 NNP denotes Rb
T24384 25775-25779 NNP denotes Cell
T24385 25780-25785 NNP denotes Cycle
T24386 25786-25793 NNP denotes Pathway
T24387 25794-25795 -LRB- denotes (
T24388 25795-25796 NN denotes A
T24389 25797-25800 CC denotes and
T24390 25801-25802 NN denotes B
T24391 25802-25803 -RRB- denotes )
T24392 25804-25814 NN denotes Immunoblot
T24393 25815-25823 NN denotes analysis
T24394 25824-25826 IN denotes of
T24395 25827-25835 VB denotes purified
T24396 25836-25837 NN denotes B
T24397 25838-25843 NN denotes cells
T24398 25844-25845 -LRB- denotes (
T24399 25845-25850 JJ denotes CD19+
T24400 25850-25851 -RRB- denotes )
T24401 25852-25856 IN denotes from
T24402 25857-25860 DT denotes the
T24403 25861-25868 NN denotes spleens
T24404 25869-25871 IN denotes of
T24405 25872-25874 NN denotes WT
T24406 25875-25878 CC denotes and
T24407 25879-25883 NN denotes LMP1
T24408 25884-25894 JJ denotes transgenic
T24409 25895-25899 NN denotes mice
T24410 25900-25903 IN denotes for
T24411 25904-25907 NN denotes Akt
T24412 25908-25917 NN denotes signaling
T24413 25917-25918 -COMMA- denotes ,
T24414 25919-25926 VB denotes probing
T24415 25927-25930 IN denotes for
T24416 25931-25932 -LRB- denotes (
T24417 25932-25933 NN denotes A
T24418 25933-25934 -RRB- denotes )
T24419 25935-25944 VB denotes activated
T24420 25945-25949 NN denotes pAkt
T24421 25950-25953 CC denotes and
T24422 25954-25964 JJ denotes downstream
T24423 25965-25972 NN denotes targets
T24424 25972-25973 -COMMA- denotes ,
T24425 25974-25983 VB denotes including
T24426 25984-25995 VB denotes inactivated
T24427 25996-26004 NN denotes pGSK3α/β
T24428 26004-26005 -COMMA- denotes ,
T24429 26006-26009 CC denotes and
T24430 26010-26011 -LRB- denotes (
T24431 26011-26012 NN denotes B
T24432 26012-26013 -RRB- denotes )
T24433 26014-26023 VB denotes activated
T24434 26024-26030 NN denotes p-mTOR
T24435 26030-26031 -COMMA- denotes ,
T24436 26032-26035 CC denotes and
T24437 26036-26041 JJ denotes total
T24438 26042-26048 NN denotes levels
T24439 26049-26051 IN denotes of
T24440 26052-26057 NN denotes FoxO1
T24441 26059-26065 NN denotes Arrows
T24442 26066-26074 VB denotes indicate
T24443 26075-26078 DT denotes the
T24444 26079-26088 NN denotes positions
T24445 26089-26091 IN denotes of
T24446 26092-26093 NN denotes α
T24447 26094-26097 CC denotes and
T24448 26098-26099 VB denotes β
T24449 26100-26108 NN denotes isoforms
T24450 26109-26111 IN denotes of
T24451 26112-26116 NN denotes GSK3
T24452 26118-26121 DT denotes The
T24453 26122-26127 JJ denotes white
T24454 26128-26132 NN denotes line
T24455 26133-26142 VB denotes indicates
T24456 26143-26147 IN denotes that
T24457 26148-26159 VB denotes intervening
T24458 26160-26165 NN denotes lanes
T24459 26166-26170 VB denotes have
T24460 26171-26175 VB denotes been
T24461 26176-26183 VB denotes spliced
T24462 26184-26187 RP denotes out
T24463 26189-26190 -LRB- denotes (
T24464 26190-26191 NN denotes C
T24465 26191-26192 -RRB- denotes )
T24466 26193-26203 NN denotes Immunoblot
T24467 26204-26212 NN denotes analysis
T24468 26213-26216 IN denotes for
T24469 26217-26221 NN denotes cell
T24470 26222-26227 NN denotes cycle
T24471 26228-26236 NN denotes proteins
T24472 26237-26247 VB denotes regulating
T24473 26248-26251 DT denotes the
T24474 26252-26254 NN denotes Rb
T24475 26255-26262 NN denotes pathway
T24476 26262-26263 -COMMA- denotes ,
T24477 26264-26271 VB denotes probing
T24478 26272-26275 IN denotes for
T24479 26276-26285 VB denotes activated
T24480 26286-26289 NN denotes pRb
T24481 26289-26290 -COMMA- denotes ,
T24482 26291-26294 CC denotes and
T24483 26295-26300 JJ denotes total
T24484 26301-26307 NN denotes levels
T24485 26308-26310 IN denotes of
T24486 26311-26315 NN denotes Cdk2
T24487 26316-26319 CC denotes and
T24488 26320-26323 DT denotes the
T24489 26324-26327 NN denotes Cdk
T24490 26328-26337 NN denotes inhibitor
T24491 26338-26341 NN denotes p27
T24492 26343-26348 NN denotes Actin
T24493 26349-26352 VB denotes was
T24494 26353-26357 VB denotes used
T24495 26358-26360 IN denotes as
T24496 26361-26362 DT denotes a
T24497 26363-26370 NN denotes loading
T24498 26371-26378 NN denotes control
T24804 30201-30204 NN denotes Akt
T24805 30204-30205 -COMMA- denotes ,
T24806 30206-30210 NN denotes NFκB
T24807 30210-30211 -COMMA- denotes ,
T24808 30212-30215 CC denotes and
T24809 30216-30221 NN denotes Stat3
T24810 30222-30231 NN denotes Signaling
T24811 30232-30235 VB denotes Are
T24812 30236-30244 VB denotes Required
T24813 30245-30248 IN denotes for
T24814 30249-30252 DT denotes the
T24815 30253-30259 NN denotes Growth
T24816 30260-30263 CC denotes and
T24817 30264-30272 NN denotes Survival
T24818 30273-30275 IN denotes of
T24819 30276-30284 NN denotes Lymphoma
T24820 30285-30290 NN denotes Cells
T24821 30291-30294 NN denotes MTS
T24822 30295-30300 NN denotes assay
T24823 30301-30303 IN denotes of
T24824 30304-30315 NN denotes splenocytes
T24825 30316-30320 IN denotes from
T24826 30321-30322 -LRB- denotes (
T24827 30322-30323 NN denotes A
T24828 30324-30327 CC denotes and
T24829 30328-30329 NN denotes B
T24830 30329-30330 -RRB- denotes )
T24831 30331-30333 NN denotes WT
T24832 30334-30336 CC denotes or
T24833 30337-30338 -LRB- denotes (
T24834 30338-30339 NN denotes C
T24835 30340-30343 CC denotes and
T24836 30344-30345 NN denotes D
T24837 30345-30346 -RRB- denotes )
T24838 30347-30351 NN denotes LMP1
T24839 30352-30362 JJ denotes transgenic
T24840 30363-30372 NN denotes lymphomas
T24841 30373-30376 CC denotes and
T24842 30377-30378 -LRB- denotes (
T24843 30378-30379 NN denotes E
T24844 30380-30383 CC denotes and
T24845 30384-30385 NN denotes F
T24846 30385-30386 -RRB- denotes )
T24847 30387-30391 NN denotes LMP1
T24848 30392-30402 JJ denotes transgenic
T24849 30403-30414 NN denotes lymphoctyes
T24850 30416-30427 NN denotes Splenocytes
T24851 30428-30432 VB denotes were
T24852 30433-30441 VB denotes cultured
T24853 30442-30446 IN denotes with
T24854 30447-30449 CC denotes or
T24855 30450-30457 IN denotes without
T24856 30458-30468 NN denotes inhibitors
T24857 30469-30471 IN denotes of
T24858 30472-30476 NN denotes NFκB
T24859 30477-30478 -LRB- denotes (
T24860 30478-30483 NN denotes BAY11
T24861 30483-30484 -RRB- denotes )
T24862 30484-30485 -COMMA- denotes ,
T24863 30486-30490 NN denotes mTOR
T24864 30491-30492 -LRB- denotes (
T24865 30492-30501 NN denotes rapamycin
T24866 30501-30502 -RRB- denotes )
T24867 30502-30503 -COMMA- denotes ,
T24868 30504-30507 NN denotes Akt
T24869 30508-30509 -LRB- denotes (
T24870 30509-30520 NN denotes triciribine
T24871 30520-30521 -RRB- denotes )
T24872 30521-30522 -COMMA- denotes ,
T24873 30523-30529 NN denotes MEK1/2
T24874 30530-30531 -LRB- denotes (
T24875 30531-30536 NN denotes U0126
T24876 30536-30537 -RRB- denotes )
T24877 30537-30538 -COMMA- denotes ,
T24878 30539-30542 NN denotes p38
T24879 30543-30544 -LRB- denotes (
T24880 30544-30552 NN denotes SB202190
T24881 30552-30553 -RRB- denotes )
T24882 30553-30554 -COMMA- denotes ,
T24883 30555-30557 CC denotes or
T24884 30558-30563 NN denotes Stat3
T24885 30564-30565 -LRB- denotes (
T24886 30565-30577 NN denotes cucurbitacin
T24887 30578-30579 CD denotes I
T24888 30580-30583 CC denotes and
T24889 30584-30589 NN denotes AG490
T24890 30589-30590 -RRB- denotes )
T24891 30591-30593 IN denotes at
T24892 30594-30597 DT denotes the
T24893 30598-30607 VB denotes indicated
T24894 30608-30622 NN denotes concentrations
T24895 30624-30627 DT denotes The
T24896 30628-30635 NN denotes results
T24897 30636-30639 VB denotes are
T24898 30640-30643 DT denotes the
T24899 30644-30648 JJ denotes mean
T24900 30649-30650 JJ denotes ±
T24901 30651-30654 NN denotes SEM
T24902 30655-30657 IN denotes of
T24903 30658-30668 JJ denotes triplicate
T24904 30669-30676 NN denotes samples
T24905 30678-30683 VB denotes Shown
T24906 30684-30687 VB denotes are
T24907 30688-30691 DT denotes the
T24908 30692-30699 NN denotes results
T24909 30700-30703 IN denotes for
T24910 30704-30705 -LRB- denotes (
T24911 30705-30706 NN denotes A
T24912 30707-30710 CC denotes and
T24913 30711-30712 NN denotes B
T24914 30712-30713 -RRB- denotes )
T24915 30714-30716 JJ denotes WT
T24916 30717-30725 NN denotes lymphoma
T24917 30726-30727 CD denotes 1
T24918 30727-30728 -COMMA- denotes ,
T24919 30729-30730 -LRB- denotes (
T24920 30730-30731 NN denotes C
T24921 30732-30735 CC denotes and
T24922 30736-30737 NN denotes D
T24923 30737-30738 -RRB- denotes )
T24924 30739-30743 NN denotes LMP1
T24925 30744-30754 JJ denotes transgenic
T24926 30755-30763 NN denotes lymphoma
T24927 30764-30765 CD denotes 2
T24928 30765-30766 -COMMA- denotes ,
T24929 30767-30770 CC denotes and
T24930 30771-30772 -LRB- denotes (
T24931 30772-30773 NN denotes E
T24932 30774-30777 CC denotes and
T24933 30778-30779 NN denotes F
T24934 30779-30780 -RRB- denotes )
T24935 30781-30784 CD denotes one
T24936 30785-30788 IN denotes out
T24937 30789-30791 IN denotes of
T24938 30792-30795 CD denotes two
T24939 30796-30800 NN denotes LMP1
T24940 30801-30811 JJ denotes transgenic
T24941 30812-30816 NN denotes mice
T24942 30817-30825 VB denotes analyzed
T24943 30827-30831 DT denotes This
T24944 30832-30840 NN denotes analysis
T24945 30841-30844 VB denotes was
T24946 30845-30853 VB denotes repeated
T24947 30854-30858 IN denotes with
T24948 30859-30863 NN denotes LMP1
T24949 30864-30874 JJ denotes transgenic
T24950 30875-30883 NN denotes lymphoma
T24951 30884-30885 CD denotes 4
T24952 30886-30894 NN denotes yielding
T24953 30895-30902 JJ denotes similar
T24954 30903-30910 NN denotes results
T25244 30922-30930 NN denotes Analysis
T25245 30931-30933 IN denotes of
T25246 30934-30937 NN denotes Akt
T25247 30937-30938 -COMMA- denotes ,
T25248 30939-30943 NN denotes NFκB
T25249 30943-30944 -COMMA- denotes ,
T25250 30945-30948 CC denotes and
T25251 30949-30954 NN denotes Stat3
T25252 30955-30963 NN denotes Pathways
T25253 30964-30966 IN denotes in
T25254 30967-30979 NN denotes Contribution
T25255 30980-30982 TO denotes to
T25256 30983-30986 DT denotes the
T25257 30987-30993 NN denotes Growth
T25258 30994-30997 CC denotes and
T25259 30998-31006 NN denotes Survival
T25260 31007-31009 IN denotes of
T25261 31010-31018 NN denotes Lymphoma
T25262 31019-31024 NN denotes Cells
T25263 31025-31026 -LRB- denotes (
T25264 31026-31029 NN denotes A–D
T25265 31029-31030 -RRB- denotes )
T25266 31031-31041 NN denotes Immunoblot
T25267 31042-31050 NN denotes analysis
T25268 31051-31053 IN denotes of
T25269 31054-31063 JJ denotes wild-type
T25270 31064-31067 CC denotes and
T25271 31068-31072 NN denotes LMP1
T25272 31073-31083 JJ denotes transgenic
T25273 31084-31093 NN denotes lymphomas
T25274 31094-31097 IN denotes for
T25275 31098-31101 NN denotes Akt
T25276 31101-31102 -COMMA- denotes ,
T25277 31103-31107 NN denotes NFκB
T25278 31107-31108 -COMMA- denotes ,
T25279 31109-31112 CC denotes and
T25280 31113-31118 NN denotes Stat3
T25281 31119-31128 NN denotes signaling
T25282 31129-31134 IN denotes after
T25283 31135-31144 NN denotes treatment
T25284 31145-31149 IN denotes with
T25285 31150-31151 -LRB- denotes (
T25286 31151-31152 NN denotes A
T25287 31152-31153 -RRB- denotes )
T25288 31154-31156 DT denotes an
T25289 31157-31160 NN denotes Akt
T25290 31161-31170 NN denotes inhibitor
T25291 31170-31171 -COMMA- denotes ,
T25292 31172-31183 NN denotes triciribine
T25293 31183-31184 -COMMA- denotes ,
T25294 31185-31186 -LRB- denotes (
T25295 31186-31187 NN denotes B
T25296 31187-31188 -RRB- denotes )
T25297 31189-31191 DT denotes an
T25298 31192-31196 NN denotes NFκB
T25299 31197-31206 NN denotes inhibitor
T25300 31206-31207 -COMMA- denotes ,
T25301 31208-31218 NN denotes BAY11–7085
T25302 31218-31219 -COMMA- denotes ,
T25303 31220-31223 CC denotes and
T25304 31224-31227 DT denotes the
T25305 31228-31233 NN denotes Stat3
T25306 31234-31244 NN denotes inhibitors
T25307 31245-31246 -LRB- denotes (
T25308 31246-31247 NN denotes C
T25309 31247-31248 -RRB- denotes )
T25310 31249-31261 NN denotes cucurbitacin
T25311 31262-31263 CD denotes I
T25312 31264-31267 CC denotes and
T25313 31268-31269 -LRB- denotes (
T25314 31269-31270 NN denotes D
T25315 31270-31271 -RRB- denotes )
T25316 31272-31277 NN denotes AG490
T25317 31277-31278 -COMMA- denotes ,
T25318 31279-31281 IN denotes at
T25319 31282-31285 DT denotes the
T25320 31286-31295 VB denotes indicated
T25321 31296-31310 NN denotes concentrations
T25322 31312-31318 NN denotes Arrows
T25323 31319-31327 VB denotes indicate
T25324 31328-31331 DT denotes the
T25325 31332-31341 NN denotes positions
T25326 31342-31344 IN denotes of
T25327 31345-31346 NN denotes α
T25328 31347-31350 CC denotes and
T25329 31351-31352 VB denotes β
T25330 31353-31361 NN denotes isoforms
T25331 31362-31364 IN denotes of
T25332 31365-31370 NN denotes Stat3
T25333 31372-31377 NN denotes Actin
T25334 31378-31381 VB denotes was
T25335 31382-31386 VB denotes used
T25336 31387-31389 IN denotes as
T25337 31390-31391 DT denotes a
T25338 31392-31399 NN denotes loading
T25339 31400-31407 NN denotes control
T4120 9020-9024 NN denotes LMP1
T4121 9025-9033 VB denotes Promotes
T4122 9034-9038 NN denotes B-1a
T4123 9039-9048 NN denotes Lymphomas
T4124 9049-9053 WDT denotes That
T4125 9054-9057 MD denotes Can
T4126 9058-9064 NNP denotes Escape
T4127 9065-9072 NNP denotes Allelic
T4128 9073-9082 NNP denotes Exclusion
T4129 9083-9085 TO denotes To
T4130 9086-9095 VB denotes determine
T4131 9096-9098 IN denotes if
T4132 9099-9103 NN denotes LMP1
T4133 9104-9113 NN denotes signaling
T4134 9114-9121 VB denotes affects
T4135 9122-9123 NN denotes B
T4136 9124-9128 NN denotes cell
T4137 9129-9144 NN denotes differentiation
T4138 9145-9148 CC denotes and
T4139 9149-9151 TO denotes to
T4140 9152-9167 VB denotes immunophenotype
T4141 9168-9171 DT denotes the
T4142 9172-9181 NN denotes lymphomas
T4143 9182-9186 WDT denotes that
T4144 9187-9192 VB denotes arise
T4145 9193-9197 IN denotes from
T4146 9198-9202 NN denotes LMP1
T4147 9203-9213 NN denotes expression
T4148 9213-9214 -COMMA- denotes ,
T4149 9215-9222 NN denotes surface
T4150 9223-9225 NN denotes Ig
T4151 9226-9236 NN denotes expression
T4152 9237-9239 IN denotes of
T4153 9240-9245 JJ denotes heavy
T4154 9246-9252 NN denotes chains
T4155 9253-9254 -LRB- denotes (
T4156 9254-9257 NN denotes IgM
T4157 9257-9258 -COMMA- denotes ,
T4158 9259-9262 NN denotes IgG
T4159 9262-9263 -COMMA- denotes ,
T4160 9264-9267 NN denotes IgD
T4161 9267-9268 -RRB- denotes )
T4162 9269-9272 CC denotes and
T4163 9273-9278 JJ denotes light
T20847 48991-48995 VB denotes were
T20848 48996-48998 CD denotes 94
T20849 48999-49001 NN denotes °C
T20850 49002-49005 IN denotes for
T20851 49006-49007 CD denotes 2
T20852 49008-49011 NN denotes min
T20853 49011-49012 -COMMA- denotes ,
T20854 49013-49015 CD denotes 40
T20855 49016-49022 NN denotes cycles
T20856 49023-49025 IN denotes of
T20857 49026-49028 CD denotes 94
T20858 49029-49031 NN denotes °C
T20859 49032-49035 IN denotes for
T20860 49036-49038 CD denotes 30
T20861 49039-49040 NN denotes s
T20862 49040-49041 -COMMA- denotes ,
T20863 49042-49044 CD denotes 63
T20864 49045-49047 NN denotes °C
T20865 49048-49051 IN denotes for
T20866 49052-49054 CD denotes 90
T20867 49055-49056 NN denotes s
T20868 49056-49057 -COMMA- denotes ,
T20869 49058-49061 CC denotes and
T20870 49062-49064 CD denotes 72
T20871 49065-49067 NN denotes °C
T20872 49068-49071 IN denotes for
T20873 49072-49073 CD denotes 1
T20874 49074-49077 NN denotes min
T20875 49077-49078 -COMMA- denotes ,
T20876 49079-49087 VB denotes followed
T20877 49088-49090 IN denotes by
T20878 49091-49092 CD denotes 1
T20879 49093-49098 NN denotes cycle
T20880 49099-49101 IN denotes of
T20881 49102-49104 CD denotes 72
T20882 49105-49107 NN denotes °C
T20883 49108-49111 IN denotes for
T20884 49112-49113 CD denotes 5
T20885 49114-49117 NN denotes min
T25510 16904-16911 NN denotes Summary
T25511 16912-16914 IN denotes of
T25512 16915-16923 NN denotes Analysis
T25513 16924-16933 NNP denotes Performed
T25514 16934-16936 IN denotes on
T25515 16937-16946 NNP denotes Wild-Type
T25516 16947-16950 CC denotes and
T25517 16951-16955 NN denotes LMP1
T25518 16956-16966 JJ denotes Transgenic
T25519 16967-16976 NN denotes Lymphomas
R9394 T12394 T12393 arg2Of viability,of
R9395 T12394 T12395 arg1Of viability,(
R9396 T12396 T12395 arg2Of Figure,(
R9397 T12396 T12397 arg1Of Figure,8
R9398 T12398 T12395 arg3Of ),(
R9399 T12402 T12399 arg1Of inhibitor,A
R9400 T12402 T12400 arg1Of inhibitor,second
R9401 T12402 T12401 arg2Of inhibitor,reported
R9402 T12402 T12403 arg1Of inhibitor,of
R9403 T12402 T12405 arg1Of inhibitor,","
R9404 T12402 T12408 arg1Of inhibitor,had
R9405 T12404 T12403 arg2Of Stat3,of
R9406 T12406 T12405 arg2Of AG490,","
R9407 T12408 T12407 arg1Of had,","
R9408 T12408 T12411 arg1Of had,on
R9409 T12408 T12418 arg1Of had,but
R9410 T12410 T12408 arg2Of effect,had
R9411 T12410 T12409 arg1Of effect,no
R9412 T12412 T12411 arg2Of growth,on
R9413 T12412 T12413 arg1Of growth,(
R9414 T12414 T12413 arg2Of Figure,(
R9415 T12414 T12415 arg1Of Figure,7
R9416 T12416 T12413 arg3Of ),(
R9417 T12418 T12417 arg1Of but,","
R9418 T12419 T12420 arg1Of activation,of
R9419 T12419 T12429 arg1Of activation,were
R9420 T12419 T12432 arg2Of activation,affected
R9421 T12421 T12422 arg1Of Akt,","
R9422 T12422 T12425 arg1Of ",",or
R9423 T12423 T12422 arg2Of Stat3,","
R9424 T12425 T12420 arg2Of or,of
R9425 T12425 T12424 arg1Of or,","
R9426 T12425 T12427 arg1Of or,of
R9427 T12426 T12425 arg2Of levels,or
R9428 T12428 T12427 arg2Of IκBα,of
R9429 T12432 T12418 arg2Of affected,but
R9430 T12432 T12429 arg2Of affected,were
R9431 T12432 T12430 arg1Of affected,also
R9432 T12432 T12431 arg1Of affected,not
R9433 T12432 T12433 arg1Of affected,(
R9434 T12434 T12433 arg2Of Figure,(
R9435 T12434 T12435 arg1Of Figure,8
R9436 T12436 T12433 arg3Of ),(
R9437 T12438 T12437 arg1Of findings,These
R9438 T12438 T12439 arg1Of findings,suggest
R9439 T12441 T12442 arg1Of inhibition,of
R9440 T12441 T12444 arg1Of inhibition,can
R9441 T12441 T12445 arg1Of inhibition,induce
R9442 T12443 T12442 arg2Of Stat3,of
R9443 T12445 T12444 arg2Of induce,can
R9444 T12445 T12448 arg1Of induce,in
R9445 T12445 T12456 arg1Of induce,but
R9446 T12447 T12445 arg2Of death,induce
R9447 T12447 T12446 arg1Of death,cell
R9448 T12451 T12449 arg1Of lymphocytes,LMP1
R9449 T12451 T12450 arg1Of lymphocytes,transgenic
R9450 T12451 T12452 arg1Of lymphocytes,and
R9451 T12452 T12448 arg2Of and,in
R9452 T12454 T12452 arg2Of cells,and
R9453 T12454 T12453 arg1Of cells,lymphoma
R9454 T12456 T12439 arg2Of but,suggest
R9455 T12456 T12440 arg1Of but,that
R9456 T12456 T12455 arg1Of but,","
R9457 T12458 T12457 arg1Of inhibition,Stat3
R9458 T12458 T12460 arg1Of inhibition,has
R9459 T12460 T12456 arg2Of has,but
R9460 T12460 T12459 arg1Of has,also
R9461 T12460 T12464 arg1Of has,on
R9462 T12463 T12460 arg2Of effects,has
R9463 T12463 T12461 arg1Of effects,considerable
R9464 T12463 T12462 arg1Of effects,crossover
R9465 T12465 T12466 arg1Of Akt,and
R9466 T12467 T12466 arg2Of NFκB,and
R9467 T12468 T12464 arg2Of signaling,on
R9468 T12468 T12465 arg1Of signaling,Akt
R9469 T12468 T12467 arg1Of signaling,NFκB
R9470 T12469 T12470 arg1Of LMP1,has
R9471 T12469 T12472 arg1Of LMP1,been
R9472 T12469 T12473 arg2Of LMP1,shown
R9473 T12469 T12475 arg1Of LMP1,activate
R9474 T12473 T12470 arg2Of shown,has
R9475 T12473 T12471 arg1Of shown,also
R9476 T12473 T12472 arg2Of shown,been
R9477 T12473 T12485 arg1Of shown,and
R9478 T12475 T12473 arg3Of activate,shown
R9479 T12475 T12474 arg1Of activate,to
R9480 T12476 T12477 arg1Of JNK,and
R9481 T12478 T12477 arg2Of p38,and
R9482 T12480 T12475 arg2Of pathways,activate
R9483 T12480 T12476 arg1Of pathways,JNK
R9484 T12480 T12478 arg1Of pathways,p38
R9485 T12480 T12479 arg1Of pathways,MAPK
R9486 T12480 T12481 arg1Of pathways,[
R9487 T12482 T12481 arg2Of "13,48",[
R9488 T12483 T12481 arg3Of ],[
R9489 T12485 T12484 arg1Of and,","
R9490 T12488 T12486 arg1Of lymphocytes,LMP1
R9491 T12488 T12487 arg1Of lymphocytes,transgenic
R9492 T12488 T12489 arg1Of lymphocytes,were
R9493 T12488 T12491 arg1Of lymphocytes,susceptible
R9494 T12489 T12485 arg2Of were,and
R9495 T12491 T12489 arg2Of susceptible,were
R9496 T12491 T12490 arg1Of susceptible,mildly
R9497 T12491 T12492 arg1Of susceptible,to
R9498 T12494 T12492 arg2Of inhibition,to
R9499 T12494 T12493 arg1Of inhibition,growth
R9500 T12494 T12495 arg1Of inhibition,by
R9501 T12496 T12497 arg1Of SB202190,","
R9502 T12496 T12504 arg1Of SB202190,but
R9503 T12499 T12497 arg2Of inhibitor,","
R9504 T12499 T12498 arg1Of inhibitor,an
R9505 T12499 T12500 arg1Of inhibitor,of
R9506 T12502 T12500 arg2Of MAPK,of
R9507 T12502 T12501 arg1Of MAPK,p38
R9508 T12504 T12495 arg2Of but,by
R9509 T12504 T12503 arg1Of but,","
R9510 T12504 T12505 arg1Of but,not
R9511 T12506 T12504 arg2Of U0126,but
R9512 T12506 T12507 arg1Of U0126,","
R9513 T12509 T12507 arg2Of inhibitor,","
R9514 T12509 T12508 arg1Of inhibitor,an
R9515 T12509 T12510 arg1Of inhibitor,of
R9516 T12512 T12510 arg2Of activity,of
R9517 T12512 T12511 arg1Of activity,MEK1/2
R9518 T12515 T12516 arg1Of effects,of
R9519 T12515 T12518 arg1Of effects,were
R9520 T12515 T12520 arg1Of effects,apparent
R9521 T12517 T12516 arg2Of SB202190,of
R9522 T12518 T12513 arg1Of were,However
R9523 T12518 T12514 arg1Of were,","
R9524 T12518 T12521 arg1Of were,at
R9525 T12518 T12539 arg1Of were,","
R9526 T12518 T12540 modOf were,suggesting
R9527 T12520 T12518 arg2Of apparent,were
R9528 T12520 T12519 arg1Of apparent,only
R9529 T12523 T12521 arg2Of doses,at
R9530 T12523 T12522 arg1Of doses,high
R9531 T12523 T12524 arg1Of doses,(
R9532 T12523 T12529 arg1Of doses,","
R9533 T12523 T12531 arg1Of doses,higher
R9534 T12526 T12525 arg1Of 10,>
R9535 T12527 T12524 arg2Of μM,(
R9536 T12527 T12526 arg1Of μM,10
R9537 T12528 T12524 arg3Of ),(
R9538 T12531 T12530 arg1Of higher,much
R9539 T12531 T12532 arg1Of higher,than
R9540 T12535 T12532 arg2Of IC50,than
R9541 T12535 T12533 arg1Of IC50,the
R9542 T12535 T12534 arg2Of IC50,reported
R9543 T12535 T12536 arg1Of IC50,of
R9544 T12538 T12536 arg2Of μM,of
R9545 T12538 T12537 arg1Of μM,0.35
R9546 T12543 T12542 arg1Of MAPK,p38
R9547 T12543 T12544 arg1Of MAPK,does
R9548 T12543 T12547 arg1Of MAPK,contribute
R9549 T12547 T12540 arg2Of contribute,suggesting
R9550 T12547 T12541 arg1Of contribute,that
R9551 T12547 T12544 arg2Of contribute,does
R9552 T12547 T12545 arg1Of contribute,not
R9553 T12547 T12546 arg1Of contribute,significantly
R9554 T12547 T12548 arg1Of contribute,to
R9555 T12551 T12548 arg2Of viability,to
R9556 T12551 T12549 arg1Of viability,the
R9557 T12551 T12550 arg2Of viability,enhanced
R9558 T12551 T12552 arg1Of viability,in
R9559 T12555 T12553 arg1Of lymphocytes,LMP1
R9560 T12555 T12554 arg1Of lymphocytes,transgenic
R9561 T12555 T12556 arg1Of lymphocytes,or
R9562 T12556 T12552 arg2Of or,in
R9563 T12558 T12556 arg2Of cells,or
R9564 T12558 T12557 arg1Of cells,lymphoma
R9565 T12558 T12559 arg1Of cells,(
R9566 T12560 T12559 arg2Of Figure,(
R9567 T12560 T12561 arg1Of Figure,7
R9568 T12562 T12559 arg3Of ),(
R9569 T12570 T12565 arg1Of lymphomas,both
R9570 T12570 T12566 arg1Of lymphomas,wild-type
R9571 T12570 T12567 arg1Of lymphomas,and
R9572 T12570 T12568 arg1Of lymphomas,LMP1
R9573 T12570 T12569 arg1Of lymphomas,transgenic
R9574 T12570 T12571 arg1Of lymphomas,were
R9575 T12570 T12573 arg1Of lymphomas,susceptible
R9576 T12570 T12625 arg1Of lymphomas,TOR
R9577 T12570 T12627 arg1Of lymphomas,id not
R9578 T12571 T12593 arg1Of were,","
R9579 T12571 T12594 modOf were,suggesting
R9580 T12571 T12624 arg1Of were,m
R9581 T12573 T12571 arg2Of susceptible,were
R9582 T12573 T12572 arg1Of susceptible,similarly
R9583 T12573 T12574 arg1Of susceptible,to
R9584 T12575 T12576 arg1Of triciribine,","
R9585 T12576 T12579 arg1Of ",",and
R9586 T12577 T12576 arg2Of BAY11–7085,","
R9587 T12579 T12578 arg1Of and,","
R9588 T12579 T12584 arg1Of and,but
R9589 T12582 T12579 arg2Of treatments,and
R9590 T12582 T12580 arg1Of treatments,cucurbitacin
R9591 T12582 T12581 arg1Of treatments,I
R9592 T12584 T12574 arg2Of but,to
R9593 T12584 T12583 arg1Of but,","
R9594 T12584 T12585 arg1Of but,not
R9595 T12586 T12587 arg1Of SB202190,","
R9596 T12587 T12590 arg1Of ",",or
R9597 T12588 T12587 arg2Of AG490,","
R9598 T12590 T12584 arg2Of or,but
R9599 T12590 T12589 arg1Of or,","
R9600 T12592 T12590 arg2Of treatment,or
R9601 T12592 T12591 arg1Of treatment,U0126
R9602 T12596 T12597 arg1Of activation,of
R9603 T12596 T12608 arg1Of activation,are
R9604 T12598 T12599 arg1Of Akt,","
R9605 T12599 T12602 arg1Of ",",and
R9606 T12600 T12599 arg2Of NFκB,","
R9607 T12602 T12601 arg1Of and,","
R9608 T12602 T12604 arg1Of and,but
R9609 T12603 T12602 arg2Of Stat3,and
R9610 T12604 T12597 arg2Of but,of
R9611 T12604 T12605 arg1Of but,not
R9612 T12607 T12604 arg2Of pathways,but
R9613 T12607 T12606 arg1Of pathways,MAPK
R9614 T12608 T12594 arg2Of are,suggesting
R9615 T12608 T12595 arg1Of are,that
R9616 T12609 T12608 arg2Of characteristics,are
R9617 T12609 T12610 arg2Of characteristics,associated
R9618 T12609 T12619 arg1Of characteristics,i
R9619 T12610 T12611 arg1Of associated,with
R9620 T12613 T12612 arg1Of transformation,malignant
R9621 T12613 T12614 arg1Of transformation,(
R9622 T12615 T12614 arg2Of Figure,(
R9623 T12615 T12616 arg1Of Figure,7
R9624 T12617 T12614 arg3Of ),(
R9625 T12618 T12611 arg2Of . rapamyc,with
R9626 T12618 T12613 arg1Of . rapamyc,transformation
R9627 T12621 T12619 arg2Of an inhibi,i
R9628 T12621 T12620 arg1Of an inhibi,"n,"
R9629 T12621 T12622 arg1Of an inhibi,to
R9630 T12623 T12622 arg2Of r of,to
R9631 T12624 T12563 arg1Of m,Interestingly
R9632 T12624 T12564 arg1Of m,","
R9633 T12624 T12638 modOf m,ymphoma ce
R9634 T12627 T12624 arg2Of id not,m
R9635 T12627 T12625 arg2Of id not,TOR
R9636 T12627 T12626 arg1Of id not,", d"
R9637 T12627 T12637 arg1Of id not,l
R9638 T12629 T12627 arg2Of ect the v,id not
R9639 T12629 T12628 arg1Of ect the v,aff
R9640 T12629 T12630 arg1Of ect the v,ia
R9641 T12633 T12632 arg1Of transgenic ,ity of the
R9642 T12633 T12634 arg1Of transgenic ,ly
R9643 T12634 T12630 arg2Of ly,ia
R9644 T12634 T12631 arg1Of ly,bil
R9645 T12636 T12634 arg2Of s or ,ly
R9646 T12636 T12635 arg1Of s or ,mphocyte
R9647 T12640 T12641 arg1Of conf,ir
R9648 T12640 T12643 arg2Of conf,g that m
R9649 T12643 T12638 arg2Of g that m,ymphoma ce
R9650 T12643 T12639 arg1Of g that m,"lls,"
R9651 T12643 T12641 arg2Of g that m,ir
R9652 T12643 T12642 arg1Of g that m,min
R9653 T12646 T12643 arg1Of s not targ,g that m
R9654 T12646 T12644 arg2Of s not targ,TO
R9655 T12646 T12645 arg1Of s not targ,R i
R9656 T12646 T12647 arg1Of s not targ,et
R9657 T12650 T12648 arg1Of vation in L,ed b
R9658 T12650 T12649 arg1Of vation in L,y Akt acti
R9659 T12650 T12651 arg1Of vation in L,MP
R9660 T12651 T12647 arg2Of MP,et
R9661 T12654 T12651 arg2Of hocyt,MP
R9662 T12654 T12652 arg1Of hocyt,1 transge
R9663 T12654 T12653 arg1Of hocyt,nic lymp
R9664 T12654 T12655 arg1Of hocyt,e
R9665 T12656 T12655 arg2Of s or m,e
R9666 T12656 T12657 arg1Of s or m,a
R9667 T12658 T12655 arg3Of l,e
R10879 T14618 T14617 arg1Of study,This
R10880 T14618 T14619 arg1Of study,defines
R10881 T14619 T14625 arg1Of defines,in
R10882 T14622 T14619 arg2Of properties,defines
R10883 T14622 T14620 arg1Of properties,the
R10884 T14622 T14621 arg1Of properties,oncogenic
R10885 T14622 T14623 arg1Of properties,of
R10886 T14624 T14623 arg2Of LMP1,of
R10887 T14626 T14625 arg2Of promoting,in
R10888 T14629 T14626 arg2Of lymphomagenesis,promoting
R10889 T14629 T14627 arg1Of lymphomagenesis,B
R10890 T14629 T14628 arg1Of lymphomagenesis,cell
R10891 T14632 T14630 arg1Of mice,LMP1
R10892 T14632 T14631 arg1Of mice,transgenic
R10893 T14632 T14633 arg1Of mice,have
R10894 T14633 T14639 arg1Of have,[
R10895 T14633 T14642 arg1Of have,and
R10896 T14636 T14633 arg2Of incidence,have
R10897 T14636 T14634 arg1Of incidence,a
R10898 T14636 T14635 arg1Of incidence,higher
R10899 T14636 T14637 arg1Of incidence,of
R10900 T14638 T14637 arg2Of lymphoma,of
R10901 T14640 T14639 arg2Of 26,[
R10902 T14641 T14639 arg3Of ],[
R10903 T14644 T14643 arg1Of progression,the
R10904 T14644 T14645 arg1Of progression,to
R10905 T14644 T14647 arg1Of progression,correlates
R10906 T14646 T14645 arg2Of lymphoma,to
R10907 T14647 T14642 arg2Of correlates,and
R10908 T14647 T14648 arg1Of correlates,with
R10909 T14647 T14660 arg1Of correlates,","
R10910 T14647 T14661 modOf correlates,suggesting
R10911 T14651 T14648 arg2Of levels,with
R10912 T14651 T14649 arg1Of levels,higher
R10913 T14651 T14650 arg1Of levels,expression
R10914 T14651 T14652 arg1Of levels,of
R10915 T14651 T14654 arg1Of levels,(
R10916 T14653 T14652 arg2Of LMP1,of
R10917 T14656 T14655 arg1Of 1A,Figure
R10918 T14656 T14657 arg1Of 1A,and
R10919 T14657 T14654 arg2Of and,(
R10920 T14658 T14657 arg2Of 1B,and
R10921 T14659 T14654 arg3Of ),(
R10922 T14663 T14664 arg1Of LMP1,is
R10923 T14663 T14666 arg2Of LMP1,involved
R10924 T14666 T14661 arg2Of involved,suggesting
R10925 T14666 T14662 arg1Of involved,that
R10926 T14666 T14664 arg2Of involved,is
R10927 T14666 T14665 arg1Of involved,directly
R10928 T14666 T14667 arg1Of involved,in
R10929 T14669 T14667 arg2Of development,in
R10930 T14669 T14668 arg1Of development,tumor
R10931 T14671 T14670 arg1Of 1,Table
R10932 T14671 T14672 arg1Of 1,summarizes
R10933 T14674 T14675 arg1Of biological,and
R10934 T14676 T14675 arg2Of molecular,and
R10935 T14677 T14672 arg2Of properties,summarizes
R10936 T14677 T14673 arg1Of properties,the
R10937 T14677 T14674 arg1Of properties,biological
R10938 T14677 T14676 arg1Of properties,molecular
R10939 T14677 T14678 arg1Of properties,that
R10940 T14677 T14679 arg1Of properties,were
R10941 T14677 T14680 arg2Of properties,identified
R10942 T14680 T14679 arg2Of identified,were
R10943 T14680 T14681 arg1Of identified,in
R10944 T14682 T14683 arg1Of wild-type,and
R10945 T14683 T14681 arg2Of and,in
R10946 T14686 T14683 arg2Of lymphomas,and
R10947 T14686 T14684 arg1Of lymphomas,LMP1
R10948 T14686 T14685 arg1Of lymphomas,transgenic
R10949 T14688 T14689 arg1Of many,of
R10950 T14688 T14694 arg1Of many,were
R10951 T14688 T14695 arg1Of many,similar
R10952 T14692 T14689 arg2Of properties,of
R10953 T14692 T14690 arg1Of properties,the
R10954 T14692 T14691 arg1Of properties,molecular
R10955 T14692 T14693 arg2Of properties,studied
R10956 T14694 T14687 arg2Of were,Although
R10957 T14695 T14694 arg2Of similar,were
R10958 T14695 T14696 arg1Of similar,between
R10959 T14697 T14698 arg1Of wild-type,and
R10960 T14698 T14696 arg2Of and,between
R10961 T14701 T14698 arg2Of lymphomas,and
R10962 T14701 T14699 arg1Of lymphomas,LMP1
R10963 T14701 T14700 arg1Of lymphomas,transgenic
R10964 T14703 T14704 arg1Of there,were
R10965 T14704 T14687 arg1Of were,Although
R10966 T14704 T14702 arg1Of were,","
R10967 T14707 T14705 arg1Of properties,distinguishing
R10968 T14707 T14706 arg1Of properties,biological
R10969 T14707 T14708 arg1Of properties,","
R10970 T14708 T14704 arg2Of ",",were
R10971 T14711 T14708 arg2Of ability,","
R10972 T14711 T14709 arg1Of ability,namely
R10973 T14711 T14710 arg1Of ability,the
R10974 T14711 T14712 arg1Of ability,of
R10975 T14711 T14716 modOf ability,to
R10976 T14715 T14712 arg2Of lymphomas,of
R10977 T14715 T14713 arg1Of lymphomas,LMP1
R10978 T14715 T14714 arg1Of lymphomas,transgenic
R10979 T14717 T14716 arg1Of induce,to
R10980 T14719 T14717 arg2Of levels,induce
R10981 T14719 T14718 arg1Of levels,higher
R10982 T14719 T14720 arg1Of levels,of
R10983 T14721 T14722 arg1Of survival,and
R10984 T14722 T14720 arg2Of and,of
R10985 T14723 T14722 arg2Of proliferation,and
R10986 T14729 T14727 arg1Of mice,LMP1
R10987 T14729 T14728 arg1Of mice,transgenic
R10988 T14729 T14730 arg1Of mice,develop
R10989 T14730 T14726 arg2Of develop,although
R10990 T14731 T14730 arg2Of lymphomas,develop
R10991 T14731 T14732 arg1Of lymphomas,in
R10992 T14731 T14738 arg1Of lymphomas,as
R10993 T14737 T14732 arg2Of type,in
R10994 T14737 T14733 arg1Of type,the
R10995 T14737 T14734 arg1Of type,same
R10996 T14737 T14735 arg1Of type,B-1a
R10997 T14737 T14736 arg1Of type,cell
R10998 T14741 T14738 arg2Of lymphomas,as
R10999 T14741 T14739 arg1Of lymphomas,spontaneous
R11000 T14741 T14740 arg1Of lymphomas,wild-type
R11001 T14741 T14742 arg1Of lymphomas,(
R11002 T14743 T14742 arg2Of Figure,(
R11003 T14743 T14744 arg1Of Figure,2
R11004 T14745 T14742 arg3Of ),(
R11005 T14749 T14747 arg1Of effects,some
R11006 T14749 T14748 arg1Of effects,signaling
R11007 T14749 T14750 arg2Of effects,induced
R11008 T14749 T14753 arg1Of effects,may
R11009 T14749 T14754 arg1Of effects,explain
R11010 T14752 T14750 arg1Of LMP1,induced
R11011 T14752 T14751 arg2Of LMP1,by
R11012 T14754 T14724 arg1Of explain,Interestingly
R11013 T14754 T14725 arg1Of explain,","
R11014 T14754 T14726 arg1Of explain,although
R11015 T14754 T14746 arg1Of explain,","
R11016 T14754 T14753 arg2Of explain,may
R11017 T14757 T14754 arg2Of promotion,explain
R11018 T14757 T14755 arg1Of promotion,the
R11019 T14757 T14756 arg2Of promotion,enhanced
R11020 T14757 T14758 arg1Of promotion,to
R11021 T14759 T14758 arg2Of lymphomagenesis,to
R11022 T14762 T14761 arg1Of mice,CD40-deficient
R11023 T14762 T14763 arg1Of mice,have
R11024 T14762 T14764 arg1Of mice,decreased
R11025 T14764 T14760 arg2Of decreased,Since
R11026 T14764 T14763 arg2Of decreased,have
R11027 T14765 T14764 arg2Of numbers,decreased
R11028 T14765 T14766 arg1Of numbers,of
R11029 T14768 T14766 arg2Of cells,of
R11030 T14768 T14767 arg1Of cells,IgMhighIgDlow
R11031 T14771 T14770 arg1Of phenotype,a
R11032 T14771 T14772 arg2Of phenotype,associated
R11033 T14771 T14793 arg2Of phenotype,contribute
R11034 T14772 T14773 arg1Of associated,with
R11035 T14774 T14775 arg1Of B-1,","
R11036 T14775 T14779 arg1Of ",",and
R11037 T14777 T14775 arg2Of zone,","
R11038 T14777 T14776 arg1Of zone,marginal
R11039 T14779 T14773 arg2Of and,with
R11040 T14779 T14778 arg1Of and,","
R11041 T14782 T14779 arg2Of cells,and
R11042 T14782 T14780 arg1Of cells,memory
R11043 T14782 T14781 arg1Of cells,B
R11044 T14785 T14784 arg1Of mimicry,the
R11045 T14785 T14786 arg1Of mimicry,of
R11046 T14785 T14789 arg1Of mimicry,by
R11047 T14785 T14791 arg1Of mimicry,could
R11048 T14785 T14793 arg1Of mimicry,contribute
R11049 T14788 T14786 arg2Of signaling,of
R11050 T14788 T14787 arg1Of signaling,CD40
R11051 T14790 T14789 arg2Of LMP1,by
R11052 T14793 T14760 arg1Of contribute,Since
R11053 T14793 T14769 arg1Of contribute,","
R11054 T14793 T14783 arg1Of contribute,","
R11055 T14793 T14791 arg2Of contribute,could
R11056 T14793 T14792 arg1Of contribute,possibly
R11057 T14793 T14794 arg1Of contribute,to
R11058 T14796 T14794 arg2Of expansion,to
R11059 T14796 T14795 arg1Of expansion,the
R11060 T14796 T14797 arg1Of expansion,of
R11061 T14796 T14800 arg1Of expansion,[
R11062 T14799 T14797 arg2Of cells,of
R11063 T14799 T14798 arg1Of cells,B-1
R11064 T14801 T14800 arg2Of 20,[
R11065 T14802 T14800 arg3Of ],[
R11066 T14803 T14804 arg1Of It,is
R11067 T14803 T14805 arg1Of It,noteworthy
R11068 T14805 T14804 arg2Of noteworthy,is
R11069 T14807 T14808 arg1Of expression,of
R11070 T14807 T14810 arg1Of expression,in
R11071 T14807 T14813 arg1Of expression,has
R11072 T14807 T14814 arg1Of expression,been
R11073 T14807 T14815 arg2Of expression,shown
R11074 T14807 T14817 arg1Of expression,inhibit
R11075 T14807 T14826 arg1Of expression,preventing
R11076 T14809 T14808 arg2Of LMP1,of
R11077 T14812 T14810 arg2Of mice,in
R11078 T14812 T14811 arg1Of mice,transgenic
R11079 T14815 T14805 arg2Of shown,noteworthy
R11080 T14815 T14806 arg1Of shown,that
R11081 T14815 T14813 arg2Of shown,has
R11082 T14815 T14814 arg2Of shown,been
R11083 T14817 T14815 arg3Of inhibit,shown
R11084 T14817 T14816 arg1Of inhibit,to
R11085 T14817 T14825 arg1Of inhibit,","
R11086 T14817 T14826 modOf inhibit,preventing
R11087 T14819 T14817 arg2Of formation,inhibit
R11088 T14819 T14818 arg1Of formation,the
R11089 T14819 T14820 arg1Of formation,of
R11090 T14821 T14820 arg2Of GCs,of
R11091 T14821 T14822 arg1Of GCs,[
R11092 T14823 T14822 arg2Of "23,49",[
R11093 T14824 T14822 arg3Of ],[
R11094 T14829 T14826 arg2Of cells,preventing
R11095 T14829 T14827 arg1Of cells,typical
R11096 T14829 T14828 arg1Of cells,B-2
R11097 T14829 T14830 arg1Of cells,from
R11098 T14832 T14833 arg1Of selection,and
R11099 T14833 T14830 arg2Of and,from
R11100 T14833 T14831 arg1Of and,antigen-driven
R11101 T14834 T14833 arg2Of expansion,and
R11102 T14836 T14835 arg1Of lack,The
R11103 T14836 T14837 arg1Of lack,of
R11104 T14836 T14840 arg1Of lack,may
R11105 T14836 T14841 arg1Of lack,contribute
R11106 T14839 T14837 arg2Of reactions,of
R11107 T14839 T14838 arg1Of reactions,GC
R11108 T14841 T14840 arg2Of contribute,may
R11109 T14841 T14842 arg1Of contribute,to
R11110 T14844 T14842 arg2Of bias,to
R11111 T14844 T14843 arg1Of bias,the
R11112 T14844 T14845 arg1Of bias,of
R11113 T14844 T14849 arg1Of bias,towards
R11114 T14848 T14845 arg2Of mice,of
R11115 T14848 T14846 arg1Of mice,LMP1
R11116 T14848 T14847 arg1Of mice,transgenic
R11117 T14852 T14849 arg2Of lymphomas,towards
R11118 T14852 T14850 arg1Of lymphomas,B-1
R11119 T14852 T14851 arg1Of lymphomas,cell
R11120 T14856 T14855 arg1Of signaling,LMP2
R11121 T14856 T14858 arg1Of signaling,favors
R11122 T14858 T14857 arg1Of favors,also
R11123 T14858 T14864 arg1Of favors,but
R11124 T14859 T14858 arg2Of development,favors
R11125 T14859 T14860 arg1Of development,of
R11126 T14862 T14860 arg2Of cells,of
R11127 T14862 T14861 arg1Of cells,B-1
R11128 T14864 T14853 arg1Of but,Interestingly
R11129 T14864 T14854 arg1Of but,","
R11130 T14864 T14863 arg1Of but,","
R11131 T14865 T14866 arg1Of this,occurs
R11132 T14866 T14864 arg2Of occurs,but
R11133 T14866 T14867 arg1Of occurs,in
R11134 T14869 T14867 arg2Of absence,in
R11135 T14869 T14868 arg1Of absence,the
R11136 T14869 T14870 arg1Of absence,of
R11137 T14871 T14870 arg2Of transformation,of
R11138 T14873 T14872 arg1Of results,These
R11139 T14873 T14874 arg1Of results,suggest
R11140 T14877 T14876 arg1Of mimicry,the
R11141 T14877 T14878 arg1Of mimicry,of
R11142 T14877 T14883 arg1Of mimicry,by
R11143 T14877 T14885 arg1Of mimicry,promotes
R11144 T14882 T14878 arg2Of signaling,of
R11145 T14882 T14879 arg1Of signaling,B
R11146 T14882 T14880 arg1Of signaling,cell
R11147 T14882 T14881 arg1Of signaling,receptor
R11148 T14884 T14883 arg2Of LMP2,by
R11149 T14885 T14874 arg2Of promotes,suggest
R11150 T14885 T14875 arg1Of promotes,that
R11151 T14888 T14886 arg1Of differentiation,B-1
R11152 T14888 T14887 arg1Of differentiation,cell
R11153 T14888 T14889 arg1Of differentiation,but
R11154 T14889 T14885 arg2Of but,promotes
R11155 T14889 T14890 arg1Of but,not
R11156 T14891 T14889 arg2Of transformation,but
R11157 T14891 T14892 arg1Of transformation,[
R11158 T14893 T14892 arg2Of "24,50,51",[
R11159 T14894 T14892 arg3Of ],[
R11160 T14896 T14895 arg1Of promotion,This
R11161 T14896 T14897 arg1Of promotion,of
R11162 T14896 T14900 arg1Of promotion,may
R11163 T14896 T14901 arg1Of promotion,account
R11164 T14899 T14897 arg2Of differentiation,of
R11165 T14899 T14898 arg1Of differentiation,B-1
R11166 T14901 T14900 arg2Of account,may
R11167 T14901 T14902 arg1Of account,for
R11168 T14904 T14902 arg2Of ability,for
R11169 T14904 T14903 arg1Of ability,the
R11170 T14904 T14905 arg1Of ability,of
R11171 T14904 T14907 modOf ability,to
R11172 T14906 T14905 arg2Of LMP2,of
R11173 T14908 T14910 arg1Of exacerbate,and
R11174 T14909 T14908 arg2Of autoimmunity,exacerbate
R11175 T14910 T14907 arg1Of and,to
R11176 T14910 T14914 arg1Of and,[
R11177 T14911 T14910 arg2Of bypass,and
R11178 T14913 T14911 arg2Of induction,bypass
R11179 T14913 T14912 arg1Of induction,anergy
R11180 T14915 T14914 arg2Of "52,53",[
R11181 T14916 T14914 arg3Of ],[
R11182 T14918 T14917 arg2Of contrast,In
R11183 T14921 T14920 arg1Of preponderance,the
R11184 T14921 T14922 arg1Of preponderance,of
R11185 T14921 T14927 arg1Of preponderance,does
R11186 T14921 T14929 arg1Of preponderance,reflect
R11187 T14923 T14922 arg2Of tumors,of
R11188 T14923 T14924 arg1Of tumors,of
R11189 T14926 T14924 arg2Of origin,of
R11190 T14926 T14925 arg1Of origin,B-1a
R11191 T14929 T14917 arg1Of reflect,In
R11192 T14929 T14919 arg1Of reflect,","
R11193 T14929 T14927 arg2Of reflect,does
R11194 T14929 T14928 arg1Of reflect,not
R11195 T14929 T14938 arg1Of reflect,","
R11196 T14929 T14939 arg1Of reflect,as
R11197 T14930 T14929 arg2Of effects,reflect
R11198 T14930 T14931 arg1Of effects,of
R11199 T14930 T14934 arg1Of effects,on
R11200 T14933 T14931 arg2Of signaling,of
R11201 T14933 T14932 arg1Of signaling,LMP1
R11202 T14937 T14934 arg2Of differentiation,on
R11203 T14937 T14935 arg1Of differentiation,B
R11204 T14937 T14936 arg1Of differentiation,cell
R11205 T14942 T14940 arg1Of cells,splenic
R11206 T14942 T14941 arg1Of cells,B
R11207 T14942 T14943 arg1Of cells,from
R11208 T14942 T14948 arg1Of cells,contain
R11209 T14947 T14943 arg2Of mice,from
R11210 T14947 T14944 arg1Of mice,healthy
R11211 T14947 T14945 arg1Of mice,LMP1
R11212 T14947 T14946 arg1Of mice,transgenic
R11213 T14948 T14939 arg2Of contain,as
R11214 T14950 T14948 arg2Of numbers,contain
R11215 T14950 T14949 arg1Of numbers,similar
R11216 T14950 T14951 arg1Of numbers,of
R11217 T14952 T14953 arg1Of B-1,and
R11218 T14954 T14953 arg2Of B-2,and
R11219 T14955 T14951 arg2Of cells,of
R11220 T14955 T14952 arg1Of cells,B-1
R11221 T14955 T14954 arg1Of cells,B-2
R11222 T14955 T14956 arg1Of cells,as
R11223 T14958 T14956 arg2Of mice,as
R11224 T14958 T14957 arg1Of mice,wild-type
R11225 T14960 T14959 arg2Of support,In
R11226 T14960 T14961 arg1Of support,of
R11227 T14963 T14961 arg2Of lack,of
R12 T76 T73 arg1Of Protein,EBV
R13 T76 T74 arg1Of Protein,Latent
R14 T76 T75 arg1Of Protein,Membrane
R15 T76 T77 arg1Of Protein,1
R16 T76 T78 arg1Of Protein,Activates
R17 T79 T80 arg1Of Akt,","
R18 T80 T83 arg1Of ",",and
R19 T81 T80 arg2Of NFκB,","
R20 T83 T78 arg2Of and,Activates
R21 T83 T82 arg1Of and,","
R22 T83 T85 arg1Of and,in
R23 T84 T83 arg2Of Stat3,and
R24 T88 T85 arg2Of Lymphomas,in
R25 T88 T86 arg1Of Lymphomas,B
R26 T88 T87 arg1Of Lymphomas,Cell
R27 T91 T89 arg1Of protein,Latent
R28 T91 T90 arg1Of protein,membrane
R29 T91 T92 arg1Of protein,1
R30 T91 T93 arg1Of protein,(
R31 T91 T96 arg1Of protein,is
R32 T94 T93 arg2Of LMP1,(
R33 T95 T93 arg3Of ),(
R34 T99 T96 arg2Of oncoprotein,is
R35 T99 T97 arg1Of oncoprotein,the
R36 T99 T98 arg1Of oncoprotein,major
R37 T99 T100 arg1Of oncoprotein,of
R38 T102 T100 arg2Of virus,of
R39 T102 T101 arg1Of virus,Epstein-Barr
R40 T102 T103 arg1Of virus,(
R41 T104 T103 arg2Of EBV,(
R42 T105 T103 arg3Of ),(
R43 T108 T106 arg2Of mice,In
R44 T108 T107 arg1Of mice,transgenic
R45 T110 T111 arg1Of LMP1,promotes
R46 T111 T106 arg1Of promotes,In
R47 T111 T109 arg1Of promotes,","
R48 T111 T115 arg1Of promotes,by
R49 T114 T111 arg2Of development,promotes
R50 T114 T112 arg2Of development,increased
R51 T114 T113 arg1Of development,lymphoma
R52 T117 T115 arg2Of mo,by
R53 T117 T116 arg1Of mo,12
R54 T117 T118 arg1Of mo,of
R55 T119 T118 arg2Of age,of
R56 T121 T120 arg1Of study,This
R57 T121 T122 arg1Of study,reveals
R58 T124 T125 arg1Of lymphoma,develops
R59 T125 T122 arg2Of develops,reveals
R60 T125 T123 arg1Of develops,that
R61 T125 T126 arg1Of develops,in
R62 T128 T126 arg2Of lymphocytes,in
R63 T128 T127 arg1Of lymphocytes,B-1a
R64 T128 T129 arg1Of lymphocytes,","
R65 T131 T129 arg2Of population,","
R66 T131 T130 arg1Of population,a
R67 T131 T132 arg1Of population,that
R68 T131 T133 arg1Of population,is
R69 T131 T134 arg2Of population,associated
R70 T134 T133 arg2Of associated,is
R71 T134 T135 arg1Of associated,with
R72 T134 T137 arg1Of associated,in
R73 T136 T135 arg2Of transformation,with
R74 T139 T137 arg2Of mice,in
R75 T139 T138 arg1Of mice,older
R76 T142 T140 arg1Of cells,The
R77 T142 T141 arg1Of cells,lymphoma
R78 T142 T143 arg1Of cells,have
R79 T142 T144 arg1Of cells,deregulated
R80 T144 T143 arg2Of deregulated,have
R81 T144 T149 arg1Of deregulated,and
R82 T147 T144 arg2Of markers,deregulated
R83 T147 T145 arg1Of markers,cell
R84 T147 T146 arg1Of markers,cycle
R85 T149 T148 arg1Of and,","
R86 T150 T151 arg1Of inhibitors,of
R87 T150 T158 arg1Of inhibitors,block
R88 T152 T153 arg1Of Akt,","
R89 T153 T156 arg1Of ",",and
R90 T154 T153 arg2Of NFκB,","
R91 T156 T151 arg2Of and,of
R92 T156 T155 arg1Of and,","
R93 T157 T156 arg2Of Stat3,and
R94 T158 T149 arg2Of block,and
R95 T158 T170 arg1Of block,vitro
R96 T161 T158 arg2Of viability,block
R97 T161 T159 arg1Of viability,the
R98 T161 T160 arg2Of viability,enhanced
R99 T161 T162 arg1Of viability,of
R100 T165 T163 arg1Of lymphocytes,LMP1
R101 T165 T164 arg1Of lymphocytes,transgenic
R102 T165 T166 arg1Of lymphocytes,and
R103 T166 T162 arg2Of and,of
R104 T168 T166 arg2Of cells,and
R105 T168 T167 arg1Of cells,lymphoma
R106 T170 T169 arg1Of vitro,in
R107 T172 T171 arg1Of cells,Lymphoma
R108 T172 T173 arg1Of cells,are
R109 T172 T174 arg1Of cells,independent
R110 T172 T184 arg1Of cells,have
R111 T172 T186 arg1Of cells,activated
R112 T173 T183 arg1Of are,but
R113 T174 T173 arg2Of independent,are
R114 T174 T175 arg1Of independent,of
R115 T177 T175 arg2Of signaling,of
R116 T177 T176 arg1Of signaling,IL4/Stat6
R117 T177 T178 arg1Of signaling,for
R118 T179 T180 arg1Of survival,and
R119 T180 T178 arg2Of and,for
R120 T181 T180 arg2Of proliferation,and
R121 T183 T182 arg1Of but,","
R122 T186 T183 arg2Of activated,but
R123 T186 T184 arg2Of activated,have
R124 T186 T185 arg1Of activated,constitutively
R125 T188 T186 arg2Of signaling,activated
R126 T188 T187 arg1Of signaling,Stat3
R127 T191 T189 arg1Of targets,These
R128 T191 T190 arg1Of targets,same
R129 T191 T192 arg1Of targets,are
R130 T191 T194 arg2Of targets,deregulated
R131 T194 T192 arg2Of deregulated,are
R132 T194 T193 arg1Of deregulated,also
R133 T194 T195 arg1Of deregulated,in
R134 T198 T195 arg2Of lymphomas,in
R135 T198 T196 arg1Of lymphomas,wild-type
R136 T198 T197 arg1Of lymphomas,B-1a
R137 T198 T199 arg1Of lymphomas,that
R138 T198 T200 arg1Of lymphomas,arise
R139 T200 T201 arg1Of arise,spontaneously
R140 T200 T202 arg1Of arise,through
R141 T204 T202 arg2Of predisposition,through
R142 T204 T203 arg1Of predisposition,age
R143 T206 T205 arg1Of results,These
R144 T206 T207 arg1Of results,suggest
R145 T209 T210 arg1Of Akt,","
R146 T210 T213 arg1Of ",",and
R147 T211 T210 arg2Of NFκB,","
R148 T213 T212 arg1Of and,","
R149 T213 T216 arg1Of and,may
R150 T213 T217 arg1Of and,serve
R151 T215 T213 arg2Of pathways,and
R152 T215 T214 arg1Of pathways,Stat3
R153 T217 T207 arg2Of serve,suggest
R154 T217 T208 arg1Of serve,that
R155 T217 T216 arg2Of serve,may
R156 T217 T218 arg1Of serve,as
R157 T220 T218 arg2Of targets,as
R158 T220 T219 arg1Of targets,effective
R159 T220 T221 arg1Of targets,in
R160 T223 T221 arg2Of treatment,in
R161 T223 T222 arg1Of treatment,the
R162 T223 T224 arg1Of treatment,of
R163 T228 T224 arg2Of lymphomas,of
R164 T228 T225 arg1Of lymphomas,EBV-associated
R165 T228 T226 arg1Of lymphomas,B
R166 T228 T227 arg1Of lymphomas,cell
R510 T881 T880 arg1Of virus,Epstein-Barr
R511 T881 T882 arg1Of virus,(
R512 T881 T885 arg1Of virus,is
R513 T883 T882 arg2Of EBV,(
R514 T884 T882 arg3Of ),(
R515 T888 T885 arg2Of γ-herpesvirus,is
R516 T888 T886 arg1Of γ-herpesvirus,a
R517 T888 T887 arg1Of γ-herpesvirus,ubiquitous
R518 T888 T889 arg1Of γ-herpesvirus,that
R519 T888 T890 arg1Of γ-herpesvirus,infects
R520 T890 T893 arg1Of infects,at
R521 T891 T890 arg2Of humans,infects
R522 T893 T892 arg1Of at,predominantly
R523 T896 T893 arg2Of age,at
R524 T896 T894 arg1Of age,an
R525 T896 T895 arg1Of age,early
R526 T896 T897 arg1Of age,with
R527 T898 T899 arg1Of greater,than
R528 T900 T899 arg2Of 90,than
R529 T901 T897 arg2Of %,with
R530 T901 T898 arg1Of %,greater
R531 T901 T902 arg1Of %,of
R532 T905 T902 arg2Of population,of
R533 T905 T903 arg1Of population,the
R534 T905 T904 arg1Of population,adult
R535 T905 T906 arg2Of population,infected
R536 T906 T907 arg1Of infected,with
R537 T908 T907 arg2Of EBV,with
R538 T908 T909 arg1Of EBV,[
R539 T910 T909 arg2Of 1,[
R540 T911 T909 arg3Of ],[
R541 T912 T913 arg1Of EBV,is
R542 T912 T914 arg2Of EBV,linked
R543 T914 T913 arg2Of linked,is
R544 T914 T915 arg1Of linked,to
R545 T917 T915 arg2Of development,to
R546 T917 T916 arg1Of development,the
R547 T917 T918 arg1Of development,of
R548 T921 T920 arg1Of lymphocyte,B
R549 T921 T922 arg1Of lymphocyte,and
R550 T922 T919 arg1Of and,both
R551 T924 T922 arg2Of cell,and
R552 T924 T923 arg1Of cell,epithelial
R553 T925 T918 arg2Of malignancies,of
R554 T925 T921 arg1Of malignancies,lymphocyte
R555 T925 T924 arg1Of malignancies,cell
R556 T925 T926 arg1Of malignancies,","
R557 T925 T927 arg1Of malignancies,including
R558 T929 T928 arg1Of lymphoma,Burkitt
R559 T929 T930 arg1Of lymphoma,","
R560 T930 T937 arg1Of ",",and
R561 T932 T930 arg2Of disease,","
R562 T932 T931 arg1Of disease,Hodgkin
R563 T932 T933 arg1Of disease,(
R564 T934 T933 arg2Of HD,(
R565 T935 T933 arg3Of ),(
R566 T937 T936 arg1Of and,","
R567 T937 T944 arg1Of and,and
R568 T939 T937 arg2Of carcinoma,and
R569 T939 T938 arg1Of carcinoma,nasopharyngeal
R570 T939 T940 arg1Of carcinoma,(
R571 T941 T940 arg2Of NPC,(
R572 T942 T940 arg3Of ),(
R573 T944 T927 arg2Of and,including
R574 T944 T943 arg1Of and,","
R575 T945 T944 arg2Of cancers,and
R576 T945 T946 arg2Of cancers,linked
R577 T946 T947 arg1Of linked,to
R578 T948 T947 arg2Of immunosuppression,to
R579 T948 T949 arg1Of immunosuppression,","
R580 T948 T950 arg1Of immunosuppression,including
R581 T951 T952 arg1Of post-transplant,lymphoma
R582 T951 T953 arg1Of post-transplant,and
R583 T954 T953 arg2Of AIDS-associated,and
R584 T955 T950 arg2Of lymphomas,including
R585 T955 T951 arg1Of lymphomas,post-transplant
R586 T955 T954 arg1Of lymphomas,AIDS-associated
R587 T955 T956 arg1Of lymphomas,[
R588 T957 T956 arg2Of "2,3",[
R589 T958 T956 arg3Of ],[
R590 T960 T959 arg1Of vitro,In
R591 T961 T960 arg1Of infection,vitro
R592 T961 T962 arg1Of infection,of
R593 T961 T965 arg1Of infection,with
R594 T961 T967 arg1Of infection,induces
R595 T964 T962 arg2Of lymphocytes,of
R596 T964 T963 arg1Of lymphocytes,B
R597 T966 T965 arg2Of EBV,with
R598 T967 T972 arg1Of induces,and
R599 T970 T967 arg2Of transformation,induces
R600 T970 T968 arg1Of transformation,permanent
R601 T970 T969 arg1Of transformation,growth
R602 T972 T971 arg1Of and,","
R603 T974 T973 arg1Of ability,this
R604 T974 T975 modOf ability,to
R605 T974 T981 arg1Of ability,contributes
R606 T976 T975 arg1Of affect,to
R607 T979 T976 arg2Of regulation,affect
R608 T979 T977 arg1Of regulation,cell
R609 T979 T978 arg1Of regulation,growth
R610 T981 T972 arg2Of contributes,and
R611 T981 T980 arg1Of contributes,likely
R612 T981 T982 arg1Of contributes,to
R613 T984 T982 arg2Of development,to
R614 T984 T983 arg1Of development,the
R615 T984 T985 arg1Of development,of
R616 T986 T985 arg2Of cancer,of
R617 T987 T988 arg1Of Many,of
R618 T987 T996 arg1Of Many,","
R619 T987 T997 arg1Of Many,including
R620 T987 T1007 arg1Of Many,have
R621 T987 T1015 arg1Of Many,are
R622 T987 T1016 arg2Of Many,required
R623 T991 T988 arg2Of proteins,of
R624 T991 T989 arg1Of proteins,the
R625 T991 T990 arg1Of proteins,viral
R626 T991 T992 arg2Of proteins,expressed
R627 T992 T993 arg1Of expressed,in
R628 T995 T993 arg2Of cells,in
R629 T995 T994 arg2Of cells,transformed
R630 T1001 T999 arg1Of antigens,EBV
R631 T1001 T1000 arg1Of antigens,nuclear
R632 T1001 T1002 arg1Of antigens,and
R633 T1002 T997 arg2Of and,including
R634 T1002 T998 arg1Of and,the
R635 T1005 T1002 arg2Of proteins,and
R636 T1005 T1003 arg1Of proteins,latent
R637 T1005 T1004 arg1Of proteins,membrane
R638 T1007 T1010 arg1Of have,on
R639 T1007 T1014 arg1Of have,and
R640 T1009 T1007 arg2Of effects,have
R641 T1009 T1008 arg1Of effects,profound
R642 T1013 T1010 arg2Of regulation,on
R643 T1013 T1011 arg1Of regulation,cell
R644 T1013 T1012 arg1Of regulation,growth
R645 T1014 T1006 arg1Of and,","
R646 T1016 T1014 arg2Of required,and
R647 T1016 T1015 arg2Of required,are
R648 T1016 T1017 arg1Of required,for
R649 T1020 T1018 arg1Of infection,EBV
R650 T1020 T1019 arg1Of infection,latent
R651 T1020 T1021 arg1Of infection,and
R652 T1021 T1017 arg2Of and,for
R653 T1024 T1021 arg2Of transformation,and
R654 T1024 T1022 arg1Of transformation,B
R655 T1024 T1023 arg1Of transformation,cell
R656 T1024 T1025 arg1Of transformation,[
R657 T1026 T1025 arg2Of 1,[
R658 T1027 T1025 arg3Of ],[
R659 T1030 T1028 arg1Of protein,Latent
R660 T1030 T1029 arg1Of protein,membrane
R661 T1030 T1031 arg1Of protein,1
R662 T1030 T1032 arg1Of protein,(
R663 T1030 T1035 arg1Of protein,is
R664 T1030 T1036 arg2Of protein,considered
R665 T1033 T1032 arg2Of LMP1,(
R666 T1034 T1032 arg3Of ),(
R667 T1036 T1035 arg2Of considered,is
R668 T1036 T1042 arg1Of considered,","
R669 T1036 T1043 arg1Of considered,as
R670 T1039 T1036 arg3Of oncoprotein,considered
R671 T1039 T1037 arg1Of oncoprotein,the
R672 T1039 T1038 arg1Of oncoprotein,major
R673 T1039 T1040 arg1Of oncoprotein,of
R674 T1041 T1040 arg2Of EBV,of
R675 T1044 T1045 arg1Of it,transforms
R676 T1044 T1054 arg1Of it,is
R677 T1044 T1055 arg2Of it,expressed
R678 T1045 T1050 arg1Of transforms,in
R679 T1045 T1053 arg1Of transforms,and
R680 T1047 T1045 arg2Of fibroblasts,transforms
R681 T1047 T1046 arg1Of fibroblasts,rodent
R682 T1047 T1048 arg1Of fibroblasts,to
R683 T1049 T1048 arg2Of tumorigenicity,to
R684 T1052 T1050 arg2Of mice,in
R685 T1052 T1051 arg1Of mice,nude
R686 T1053 T1043 arg2Of and,as
R687 T1055 T1053 arg2Of expressed,and
R688 T1055 T1054 arg2Of expressed,is
R689 T1055 T1056 arg1Of expressed,in
R690 T1057 T1058 arg1Of HD,","
R691 T1058 T1061 arg1Of ",",and
R692 T1059 T1058 arg2Of NPC,","
R693 T1061 T1056 arg2Of and,in
R694 T1061 T1060 arg1Of and,","
R695 T1063 T1061 arg2Of tumors,and
R696 T1063 T1062 arg1Of tumors,immunosuppression-associated
R697 T1063 T1064 arg1Of tumors,[
R698 T1065 T1064 arg2Of 4–8,[
R699 T1066 T1064 arg3Of ],[
R700 T1069 T1067 arg2Of lymphocytes,In
R701 T1069 T1068 arg1Of lymphocytes,B
R702 T1071 T1072 arg1Of LMP1,mimics
R703 T1072 T1076 arg1Of mimics,and
R704 T1074 T1072 arg2Of signaling,mimics
R705 T1074 T1073 arg1Of signaling,CD40
R706 T1076 T1067 arg1Of and,In
R707 T1076 T1070 arg1Of and,","
R708 T1076 T1075 arg1Of and,","
R709 T1078 T1079 arg1Of LMP1,and
R710 T1079 T1077 arg1Of and,both
R711 T1079 T1081 arg1Of and,are
R712 T1079 T1082 arg1Of and,essential
R713 T1080 T1079 arg2Of CD40,and
R714 T1081 T1076 arg2Of are,and
R715 T1082 T1081 arg2Of essential,are
R716 T1082 T1083 arg1Of essential,for
R717 T1087 T1083 arg2Of transformation,for
R718 T1087 T1084 arg1Of transformation,EBV-mediated
R719 T1087 T1085 arg1Of transformation,B
R720 T1087 T1086 arg1Of transformation,cell
R721 T1087 T1088 arg1Of transformation,[
R722 T1089 T1088 arg2Of 9–11,[
R723 T1090 T1088 arg3Of ],[
R724 T1092 T1093 arg1Of CD40,interacts
R725 T1093 T1091 arg2Of interacts,While
R726 T1093 T1094 arg1Of interacts,with
R727 T1096 T1094 arg2Of ligand,with
R728 T1096 T1095 arg1Of ligand,CD40
R729 T1096 T1097 arg2Of ligand,expressed
R730 T1097 T1098 arg1Of expressed,on
R731 T1097 T1102 modOf expressed,to
R732 T1101 T1098 arg2Of cells,on
R733 T1101 T1099 arg2Of cells,activated
R734 T1101 T1100 arg1Of cells,T
R735 T1103 T1102 arg1Of induce,to
R736 T1106 T1107 arg1Of activation,and
R737 T1107 T1103 arg2Of and,induce
R738 T1107 T1104 arg1Of and,B
R739 T1107 T1105 arg1Of and,cell
R740 T1108 T1107 arg2Of differentiation,and
R741 T1110 T1111 arg1Of LMP1,acts
R742 T1111 T1091 arg1Of acts,While
R743 T1111 T1109 arg1Of acts,","
R744 T1111 T1112 arg1Of acts,as
R745 T1111 T1116 arg1Of acts,through
R746 T1115 T1112 arg2Of signal,as
R747 T1115 T1113 arg1Of signal,a
R748 T1115 T1114 arg1Of signal,constitutive
R749 T1118 T1116 arg2Of oligomerization,through
R750 T1118 T1117 arg1Of oligomerization,ligand-independent
R751 T1119 T1120 arg1Of LMP1,and
R752 T1120 T1122 arg1Of and,interact
R753 T1121 T1120 arg2Of CD40,and
R754 T1122 T1123 arg1Of interact,with
R755 T1130 T1125 arg1Of factors,same
R756 T1130 T1126 arg1Of factors,tumor
R757 T1130 T1127 arg1Of factors,necrosis
R758 T1130 T1128 arg1Of factors,factor
R759 T1130 T1129 arg2Of factors,receptor–associated
R760 T1130 T1131 arg1Of factors,(
R761 T1130 T1134 arg1Of factors,leading
R762 T1130 T1148 arg1Of factors,and
R763 T1132 T1131 arg2Of TRAFs,(
R764 T1133 T1131 arg3Of ),(
R765 T1134 T1135 arg1Of leading,to
R766 T1136 T1135 arg2Of activation,to
R767 T1136 T1137 arg1Of activation,of
R768 T1138 T1139 arg1Of NFκB,","
R769 T1139 T1137 arg2Of ",",of
R770 T1143 T1139 arg2Of kinase,","
R771 T1143 T1140 arg1Of kinase,c-Jun
R772 T1143 T1141 arg1Of kinase,N
R773 T1143 T1142 arg1Of kinase,terminal
R774 T1143 T1144 arg1Of kinase,(
R775 T1145 T1144 arg2Of JNK,(
R776 T1146 T1144 arg3Of ),(
R777 T1148 T1123 arg2Of and,with
R778 T1148 T1124 arg1Of and,the
R779 T1148 T1147 arg1Of and,","
R780 T1152 T1148 arg2Of pathways,and
R781 T1152 T1149 arg1Of pathways,p38
R782 T1152 T1150 arg1Of pathways,MAPK
R783 T1152 T1151 arg1Of pathways,signaling
R784 T1152 T1153 arg1Of pathways,[
R785 T1154 T1153 arg2Of 12–16,[
R786 T1155 T1153 arg3Of ],[
R787 T1156 T1157 arg1Of Activation,of
R788 T1156 T1159 arg1Of Activation,is
R789 T1156 T1160 arg2Of Activation,required
R790 T1158 T1157 arg2Of NFκB,of
R791 T1160 T1159 arg2Of required,is
R792 T1160 T1161 arg1Of required,for
R793 T1160 T1166 arg1Of required,and
R794 T1165 T1161 arg2Of transformation,for
R795 T1165 T1162 arg1Of transformation,EBV-induced
R796 T1165 T1163 arg1Of transformation,B
R797 T1165 T1164 arg1Of transformation,cell
R798 T1168 T1167 arg1Of inhibition,its
R799 T1168 T1170 arg1Of inhibition,results
R800 T1170 T1166 arg2Of results,and
R801 T1170 T1169 arg1Of results,rapidly
R802 T1170 T1171 arg1Of results,in
R803 T1170 T1174 arg1Of results,[
R804 T1173 T1171 arg2Of death,in
R805 T1173 T1172 arg1Of death,cell
R806 T1175 T1174 arg2Of "17,18",[
R807 T1176 T1174 arg3Of ],[
R808 T1178 T1177 arg1Of studies,Recent
R809 T1178 T1179 arg1Of studies,indicate
R810 T1181 T1183 arg1Of LMP1,activates
R811 T1183 T1180 arg1Of activates,that
R812 T1183 T1182 arg1Of activates,also
R813 T1183 T1192 arg1Of activates,and
R814 T1186 T1184 arg1Of kinase,phosphatidylinositol
R815 T1186 T1185 arg1Of kinase,3
R816 T1186 T1187 arg1Of kinase,(
R817 T1188 T1187 arg2Of PI3K,(
R818 T1189 T1187 arg3Of ),(
R819 T1191 T1183 arg2Of signaling,activates
R820 T1191 T1186 arg1Of signaling,kinase
R821 T1191 T1190 arg1Of signaling,/Akt
R822 T1192 T1179 arg2Of and,indicate
R823 T1193 T1192 arg2Of that,and
R824 T1195 T1194 arg1Of activation,this
R825 T1195 T1196 arg1Of activation,is
R826 T1195 T1197 arg2Of activation,required
R827 T1197 T1193 arg2Of required,that
R828 T1197 T1196 arg2Of required,is
R829 T1197 T1198 arg1Of required,for
R830 T1200 T1198 arg2Of transformation,for
R831 T1200 T1199 arg1Of transformation,LMP1-mediated
R832 T1200 T1201 arg1Of transformation,of
R833 T1203 T1201 arg2Of fibroblasts,of
R834 T1203 T1202 arg1Of fibroblasts,rodent
R835 T1203 T1204 arg1Of fibroblasts,[
R836 T1205 T1204 arg2Of "5,19",[
R837 T1206 T1204 arg3Of ],[
R838 T1208 T1207 arg1Of vitro,In
R839 T1212 T1210 arg1Of cells,primary
R840 T1212 T1211 arg1Of cells,B
R841 T1212 T1213 arg1Of cells,can
R842 T1212 T1214 arg1Of cells,be
R843 T1212 T1215 arg2Of cells,maintained
R844 T1215 T1208 arg1Of maintained,vitro
R845 T1215 T1209 arg1Of maintained,","
R846 T1215 T1213 arg2Of maintained,can
R847 T1215 T1214 arg2Of maintained,be
R848 T1215 T1219 arg1Of maintained,in
R849 T1218 T1215 arg1Of ligation,maintained
R850 T1218 T1216 arg2Of ligation,by
R851 T1218 T1217 arg1Of ligation,CD40
R852 T1220 T1219 arg2Of combination,in
R853 T1220 T1221 arg1Of combination,with
R854 T1223 T1221 arg2Of treatment,with
R855 T1223 T1222 arg1Of treatment,IL4
R856 T1224 T1229 modOf In,is
R857 T1228 T1227 arg1Of signaling,CD40
R858 T1228 T1229 arg1Of signaling,is
R859 T1228 T1230 arg1Of signaling,necessary
R860 T1229 T1225 arg1Of is,vivo
R861 T1229 T1226 arg1Of is,","
R862 T1230 T1229 arg2Of necessary,is
R863 T1230 T1231 arg1Of necessary,for
R864 T1233 T1231 arg2Of center,for
R865 T1233 T1232 arg1Of center,germinal
R866 T1233 T1234 arg1Of center,(
R867 T1235 T1234 arg2Of GC,(
R868 T1236 T1234 arg3Of ),(
R869 T1237 T1238 arg1Of formation,such
R870 T1238 T1224 arg1Of such,In
R871 T1240 T1241 arg1Of mice,deficient
R872 T1240 T1246 arg1Of mice,are
R873 T1240 T1247 arg1Of mice,unable
R874 T1240 T1249 arg1Of mice,form
R875 T1241 T1242 arg1Of deficient,for
R876 T1243 T1244 arg1Of CD40,or
R877 T1244 T1242 arg2Of or,for
R878 T1245 T1244 arg2Of CD40L,or
R879 T1246 T1238 arg2Of are,such
R880 T1246 T1239 arg1Of are,that
R881 T1247 T1246 arg2Of unable,are
R882 T1249 T1247 arg2Of form,unable
R883 T1249 T1248 arg1Of form,to
R884 T1249 T1251 arg1Of form,in
R885 T1250 T1249 arg2Of GCs,form
R886 T1252 T1251 arg2Of response,in
R887 T1252 T1253 arg1Of response,to
R888 T1256 T1253 arg2Of antigens,to
R889 T1256 T1254 arg1Of antigens,T
R890 T1256 T1255 arg1Of antigens,cell–dependent
R891 T1256 T1257 arg1Of antigens,[
R892 T1258 T1257 arg2Of "20,21",[
R893 T1259 T1257 arg3Of ],[
R894 T1263 T1264 arg1Of proximal,and
R895 T1265 T1264 arg2Of distal,and
R896 T1267 T1260 arg1Of regions,Both
R897 T1267 T1261 arg1Of regions,the
R898 T1267 T1262 arg1Of regions,membrane
R899 T1267 T1263 arg1Of regions,proximal
R900 T1267 T1265 arg1Of regions,distal
R901 T1267 T1266 arg1Of regions,cytoplasmic
R902 T1267 T1268 arg1Of regions,of
R903 T1267 T1270 arg1Of regions,that
R904 T1267 T1271 arg1Of regions,bind
R905 T1267 T1278 arg1Of regions,are
R906 T1267 T1279 arg1Of regions,necessary
R907 T1269 T1268 arg2Of CD40,of
R908 T1271 T1275 arg1Of bind,","
R909 T1271 T1276 arg1Of bind,respectively
R910 T1272 T1273 arg1Of TRAF6,and
R911 T1273 T1271 arg2Of and,bind
R912 T1274 T1273 arg2Of TRAFs2/3/5,and
R913 T1278 T1277 arg1Of are,","
R914 T1278 T1284 arg1Of are,but
R915 T1279 T1278 arg2Of necessary,are
R916 T1279 T1280 arg1Of necessary,for
R917 T1282 T1280 arg2Of formation,for
R918 T1282 T1281 arg1Of formation,GC
R919 T1284 T1283 arg1Of but,","
R920 T1286 T1285 arg1Of region,either
R921 T1286 T1287 arg1Of region,is
R922 T1286 T1288 arg1Of region,sufficient
R923 T1287 T1284 arg2Of is,but
R924 T1288 T1287 arg2Of sufficient,is
R925 T1290 T1295 arg1Of induce,and
R926 T1294 T1290 arg2Of differentiation,induce
R927 T1294 T1291 arg1Of differentiation,extrafollicular
R928 T1294 T1292 arg1Of differentiation,B
R929 T1294 T1293 arg1Of differentiation,cell
R930 T1295 T1288 arg2Of and,sufficient
R931 T1295 T1289 arg1Of and,to
R932 T1296 T1295 arg2Of restore,and
R933 T1296 T1301 arg1Of restore,[
R934 T1300 T1296 arg2Of production,restore
R935 T1300 T1297 arg1Of production,low
R936 T1300 T1298 arg1Of production,affinity
R937 T1300 T1299 arg1Of production,antibody
R938 T1302 T1301 arg2Of 22,[
R939 T1303 T1301 arg3Of ],[
R940 T1306 T1307 arg1Of LMP1,can
R941 T1306 T1308 arg1Of LMP1,rescue
R942 T1306 T1312 arg1Of LMP1,restore
R943 T1308 T1311 arg1Of rescue,and
R944 T1310 T1308 arg2Of mice,rescue
R945 T1310 T1309 arg1Of mice,CD40-deficient
R946 T1311 T1304 arg1Of and,Functionally
R947 T1311 T1305 arg1Of and,","
R948 T1311 T1307 arg2Of and,can
R949 T1311 T1319 arg1Of and,","
R950 T1311 T1321 arg1Of and,likely
R951 T1311 T1322 arg1Of and,because
R952 T1311 T1343 arg1Of and,","
R953 T1311 T1344 arg1Of and,respectively
R954 T1312 T1311 arg2Of restore,and
R955 T1315 T1314 arg2Of Ig,(
R956 T1316 T1314 arg3Of ),(
R957 T1318 T1312 arg2Of switching,restore
R958 T1318 T1313 arg1Of switching,immunoglobulin
R959 T1318 T1314 arg1Of switching,(
R960 T1318 T1317 arg1Of switching,class
R961 T1321 T1320 arg1Of likely,most
R962 T1323 T1324 arg1Of LMP1,recruits
R963 T1324 T1322 arg2Of recruits,because
R964 T1324 T1333 arg1Of recruits,","
R965 T1324 T1334 arg1Of recruits,through
R966 T1327 T1324 arg2Of molecules,recruits
R967 T1327 T1325 arg1Of molecules,similar
R968 T1327 T1326 arg1Of molecules,TRAF
R969 T1327 T1328 arg1Of molecules,","
R970 T1330 T1331 arg1Of 1/2/3/5,and
R971 T1331 T1328 arg2Of and,","
R972 T1331 T1329 arg1Of and,TRAFs
R973 T1332 T1331 arg2Of TRAF6,and
R974 T1338 T1336 arg1Of regions,C-terminal
R975 T1338 T1337 arg1Of regions,activation
R976 T1339 T1340 arg1Of 1,and
R977 T1341 T1340 arg2Of 2,and
R978 T1342 T1334 arg2Of domains,through
R979 T1342 T1335 arg1Of domains,the
R980 T1342 T1338 arg1Of domains,regions
R981 T1342 T1339 arg1Of domains,1
R982 T1342 T1341 arg1Of domains,2
R983 T1347 T1348 arg1Of LMP1,is
R984 T1347 T1349 arg1Of LMP1,unable
R985 T1347 T1351 arg1Of LMP1,restore
R986 T1348 T1345 arg1Of is,However
R987 T1348 T1346 arg1Of is,","
R988 T1348 T1357 arg1Of is,[
R989 T1349 T1348 arg2Of unable,is
R990 T1351 T1349 arg2Of restore,unable
R991 T1351 T1350 arg1Of restore,to
R992 T1353 T1352 arg1Of maturation,affinity
R993 T1353 T1354 arg1Of maturation,and
R994 T1354 T1351 arg2Of and,restore
R995 T1356 T1354 arg2Of formation,and
R996 T1356 T1355 arg1Of formation,GC
R997 T1358 T1357 arg2Of 23,[
R998 T1359 T1357 arg3Of ],[
R999 T1363 T1360 arg1Of proteins,Several
R1000 T1363 T1361 arg1Of proteins,EBV
R1001 T1363 T1362 arg1Of proteins,transforming
R1002 T1363 T1364 arg1Of proteins,have
R1003 T1363 T1365 arg1Of proteins,been
R1004 T1363 T1366 arg2Of proteins,studied
R1005 T1366 T1364 arg2Of studied,have
R1006 T1366 T1365 arg2Of studied,been
R1007 T1366 T1367 arg1Of studied,in
R1008 T1366 T1371 arg1Of studied,","
R1009 T1370 T1367 arg2Of models,in
R1010 T1370 T1368 arg1Of models,transgenic
R1011 T1370 T1369 arg1Of models,mouse
R1012 T1375 T1374 arg1Of LMP1,only
R1013 T1375 T1376 arg1Of LMP1,induces
R1014 T1376 T1371 arg2Of induces,","
R1015 T1376 T1372 arg1Of induces,however
R1016 T1376 T1373 arg1Of induces,","
R1017 T1376 T1379 arg1Of induces,when
R1018 T1378 T1376 arg2Of development,induces
R1019 T1378 T1377 arg1Of development,tumor
R1020 T1380 T1379 arg2Of expressed,when
R1021 T1380 T1381 arg1Of expressed,under
R1022 T1383 T1382 arg1Of control,the
R1023 T1383 T1384 arg1Of control,of
R1024 T1383 T1390 arg1Of control,and
R1025 T1389 T1384 arg2Of promoter,of
R1026 T1389 T1385 arg1Of promoter,the
R1027 T1389 T1386 arg1Of promoter,Ig
R1028 T1389 T1387 arg1Of promoter,heavy
R1029 T1389 T1388 arg1Of promoter,chain
R1030 T1390 T1381 arg2Of and,under
R1031 T1391 T1390 arg2Of enhancer,and
R1032 T1391 T1392 arg1Of enhancer,[
R1033 T1393 T1392 arg2Of 24–26,[
R1034 T1394 T1392 arg3Of ],[
R1035 T1398 T1395 arg1Of mice,The
R1036 T1398 T1396 arg1Of mice,LMP1
R1037 T1398 T1397 arg1Of mice,transgenic
R1038 T1398 T1399 arg1Of mice,(
R1039 T1398 T1402 arg1Of mice,express
R1040 T1400 T1399 arg2Of IgLMP1,(
R1041 T1401 T1399 arg3Of ),(
R1042 T1402 T1404 arg1Of express,in
R1043 T1402 T1408 arg1Of express,and
R1044 T1403 T1402 arg2Of LMP1,express
R1045 T1406 T1404 arg2Of lymphocytes,in
R1046 T1406 T1405 arg1Of lymphocytes,B
R1047 T1408 T1407 arg1Of and,","
R1048 T1410 T1409 arg2Of mice,in
R1049 T1410 T1411 arg1Of mice,older
R1050 T1411 T1412 arg1Of older,than
R1051 T1414 T1412 arg2Of mo,than
R1052 T1414 T1413 arg1Of mo,12
R1053 T1416 T1417 arg1Of lymphoma,develops
R1054 T1417 T1408 arg2Of develops,and
R1055 T1417 T1409 arg1Of develops,in
R1056 T1417 T1415 arg1Of develops,","
R1057 T1417 T1418 arg1Of develops,with
R1058 T1417 T1427 arg1Of develops,compared
R1059 T1417 T1436 arg1Of develops,","
R1060 T1417 T1437 modOf develops,suggesting
R1061 T1420 T1418 arg2Of incidence,with
R1062 T1420 T1419 arg2Of incidence,increased
R1063 T1420 T1421 arg1Of incidence,(
R1064 T1425 T1421 arg2Of %,(
R1065 T1425 T1422 arg1Of %,40
R1066 T1425 T1423 arg1Of %,%
R1067 T1425 T1424 arg1Of %,–50
R1068 T1426 T1421 arg3Of ),(
R1069 T1428 T1427 arg2Of to,compared
R1070 T1431 T1428 arg2Of mice,to
R1071 T1431 T1429 arg1Of mice,wild-type
R1072 T1431 T1430 arg1Of mice,control
R1073 T1431 T1432 arg1Of mice,(
R1074 T1434 T1432 arg2Of %,(
R1075 T1434 T1433 arg1Of %,11
R1076 T1435 T1432 arg3Of ),(
R1077 T1439 T1440 arg1Of LMP1,contributes
R1078 T1440 T1437 arg2Of contributes,suggesting
R1079 T1440 T1438 arg1Of contributes,that
R1080 T1440 T1441 arg1Of contributes,to
R1081 T1440 T1444 arg1Of contributes,[
R1082 T1443 T1441 arg2Of development,to
R1083 T1443 T1442 arg1Of development,tumor
R1084 T1445 T1444 arg2Of 26,[
R1085 T1446 T1444 arg3Of ],[
R1086 T1449 T1447 arg1Of lymphomas,The
R1087 T1449 T1448 arg1Of lymphomas,LMP1
R1088 T1449 T1450 arg1Of lymphomas,have
R1089 T1449 T1451 arg1Of lymphomas,rearranged
R1090 T1449 T1455 arg1Of lymphomas,have
R1091 T1449 T1456 arg1Of lymphomas,activated
R1092 T1451 T1450 arg2Of rearranged,have
R1093 T1451 T1454 arg1Of rearranged,and
R1094 T1453 T1451 arg2Of genes,rearranged
R1095 T1453 T1452 arg1Of genes,Ig
R1096 T1456 T1454 arg2Of activated,and
R1097 T1456 T1455 arg2Of activated,have
R1098 T1456 T1465 arg1Of activated,","
R1099 T1456 T1466 arg1Of activated,with
R1100 T1456 T1475 arg1Of activated,[
R1101 T1457 T1458 arg1Of Akt,","
R1102 T1458 T1460 arg1Of ",",","
R1103 T1459 T1458 arg2Of JNK,","
R1104 T1460 T1463 arg1Of ",",and
R1105 T1461 T1460 arg2Of p38,","
R1106 T1463 T1456 arg2Of and,activated
R1107 T1463 T1462 arg1Of and,","
R1108 T1464 T1463 arg2Of NFκB,and
R1109 T1468 T1466 arg2Of activation,with
R1110 T1468 T1467 arg1Of activation,specific
R1111 T1468 T1469 arg1Of activation,of
R1112 T1474 T1469 arg2Of cRel,of
R1113 T1474 T1470 arg1Of cRel,the
R1114 T1474 T1471 arg1Of cRel,NFκB
R1115 T1474 T1472 arg1Of cRel,family
R1116 T1474 T1473 arg1Of cRel,member
R1117 T1476 T1475 arg2Of 27,[
R1118 T1477 T1475 arg3Of ],[
R1119 T1480 T1478 arg2Of study,In
R1120 T1480 T1479 arg1Of study,this
R1121 T1485 T1486 arg1Of lymphocytes,and
R1122 T1486 T1482 arg1Of and,the
R1123 T1486 T1483 arg1Of and,LMP1
R1124 T1486 T1484 arg1Of and,transgenic
R1125 T1486 T1488 arg1Of and,were
R1126 T1486 T1490 arg2Of and,characterized
R1127 T1487 T1486 arg2Of lymphomas,and
R1128 T1490 T1488 arg2Of characterized,were
R1129 T1490 T1489 arg1Of characterized,further
R1130 T1490 T1491 arg1Of characterized,and
R1131 T1491 T1478 arg1Of and,In
R1132 T1491 T1481 arg1Of and,","
R1133 T1494 T1492 arg1Of properties,their
R1134 T1494 T1493 arg1Of properties,growth
R1135 T1494 T1496 arg1Of properties,vitro
R1136 T1494 T1497 arg1Of properties,were
R1137 T1494 T1498 arg2Of properties,determined
R1138 T1496 T1495 arg1Of vitro,in
R1139 T1498 T1491 arg2Of determined,and
R1140 T1498 T1497 arg2Of determined,were
R1141 T1500 T1499 arg1Of obtain,To
R1142 T1500 T1506 arg1Of obtain,and
R1143 T1502 T1500 arg2Of populations,obtain
R1144 T1502 T1501 arg1Of populations,pure
R1145 T1502 T1503 arg1Of populations,of
R1146 T1505 T1503 arg2Of lymphocytes,of
R1147 T1505 T1504 arg1Of lymphocytes,malignant
R1148 T1508 T1506 arg2Of enable,and
R1149 T1508 T1507 arg1Of enable,to
R1150 T1510 T1509 arg1Of detailed,more
R1151 T1512 T1508 arg2Of analyses,enable
R1152 T1512 T1510 arg1Of analyses,detailed
R1153 T1512 T1511 arg1Of analyses,biochemical
R1154 T1514 T1515 arg1Of examples,of
R1155 T1514 T1518 arg1Of examples,were
R1156 T1514 T1519 arg2Of examples,inoculated
R1157 T1514 T1521 arg2Of examples,passaged
R1158 T1517 T1515 arg2Of lymphomas,of
R1159 T1533 T1531 arg2Of lymphocytes,to
R1160 T1533 T1532 arg1Of lymphocytes,B-1a
R1161 T1533 T1534 arg1Of lymphocytes,","
R1162 T1517 T1516 arg1Of lymphomas,primary
R1163 T1519 T1520 arg1Of inoculated,and
R1164 T1537 T1534 arg2Of population,","
R1165 T1537 T1535 arg1Of population,a
R1166 T1537 T1536 arg1Of population,self-replenishing
R1167 T1537 T1538 arg1Of population,of
R1168 T1539 T1538 arg2Of cells,of
R1169 T1539 T1540 arg1Of cells,that
R1170 T1539 T1541 arg1Of cells,are
R1171 T1539 T1542 arg1Of cells,prone
R1172 T1520 T1499 modOf and,To
R1173 T1542 T1541 arg2Of prone,are
R1174 T1542 T1543 arg1Of prone,to
R1175 T1520 T1507 modOf and,to
R1176 T1544 T1543 arg2Of malignancy,to
R1177 T1544 T1545 arg1Of malignancy,[
R1178 T1520 T1513 arg1Of and,","
R1179 T1546 T1545 arg2Of "28,29",[
R1180 T1520 T1518 arg2Of and,were
R1181 T1547 T1545 arg3Of ],[
R1182 T1520 T1522 arg1Of and,in
R1183 T1521 T1520 arg2Of passaged,and
R1184 T1550 T1548 arg1Of lymphocytes,LMP1
R1185 T1550 T1549 arg1Of lymphocytes,transgenic
R1186 T1550 T1551 arg1Of lymphocytes,had
R1187 T1550 T1552 arg1Of lymphocytes,increased
R1188 T1552 T1551 arg2Of increased,had
R1189 T1552 T1555 arg1Of increased,vitro
R1190 T1552 T1556 arg1Of increased,and
R1191 T1553 T1552 arg2Of viability,increased
R1192 T1555 T1554 arg1Of vitro,in
R1193 T1524 T1522 arg2Of mice,in
R1194 T1557 T1558 arg1Of viability,was
R1195 T1557 T1559 arg2Of viability,increased
R1196 T1559 T1556 arg2Of increased,and
R1197 T1559 T1558 arg2Of increased,was
R1198 T1559 T1560 arg1Of increased,by
R1199 T1562 T1560 arg2Of addition,by
R1200 T1562 T1561 arg1Of addition,the
R1201 T1562 T1563 arg1Of addition,of
R1202 T1524 T1523 arg1Of mice,SCID
R1203 T1564 T1563 arg2Of IL4,of
R1204 T1528 T1527 arg1Of development,lymphoma
R1205 T1566 T1565 arg2Of contrast,In
R1206 T1569 T1570 arg1Of LMP1-positive,and
R1207 T1528 T1529 arg1Of development,was
R1208 T1571 T1570 arg2Of -negative,and
R1209 T1528 T1530 arg1Of development,restricted
R1210 T1573 T1568 arg1Of cells,both
R1211 T1573 T1569 arg1Of cells,LMP1-positive
R1212 T1573 T1571 arg1Of cells,-negative
R1213 T1573 T1572 arg1Of cells,lymphoma
R1214 T1573 T1574 arg1Of cells,were
R1215 T1573 T1575 arg1Of cells,independent
R1216 T1574 T1565 arg1Of were,In
R1217 T1574 T1567 arg1Of were,","
R1218 T1574 T1584 arg1Of were,vitro
R1219 T1574 T1585 arg1Of were,with
R1220 T1575 T1574 arg2Of independent,were
R1221 T1575 T1576 arg1Of independent,of
R1222 T1529 T1525 arg1Of was,Interestingly
R1223 T1578 T1576 arg2Of co-stimulation,of
R1224 T1578 T1577 arg1Of co-stimulation,IL4
R1225 T1578 T1579 arg1Of co-stimulation,for
R1226 T1580 T1581 arg1Of survival,and
R1227 T1529 T1526 arg1Of was,","
R1228 T1581 T1579 arg2Of and,for
R1229 T1530 T1529 arg2Of restricted,was
R1230 T1582 T1581 arg2Of proliferation,and
R1231 T1530 T1531 arg1Of restricted,to
R1232 T1584 T1583 arg1Of vitro,in
R1233 T1628 T1625 arg2Of growth,blocked
R1234 T1588 T1585 arg2Of absence,with
R1235 T1588 T1586 arg1Of absence,a
R1236 T1588 T1587 arg1Of absence,complete
R1237 T1588 T1589 arg1Of absence,of
R1238 T1591 T1589 arg2Of Stat6,of
R1239 T1591 T1590 arg2Of Stat6,activated
R1240 T1591 T1592 arg1Of Stat6,","
R1241 T1628 T1626 arg1Of growth,the
R1242 T1595 T1592 arg2Of target,","
R1243 T1595 T1593 arg1Of target,the
R1244 T1595 T1594 arg1Of target,IL4
R1245 T1597 T1596 arg1Of lymphomas,The
R1246 T1597 T1598 arg1Of lymphomas,were
R1247 T1597 T1600 arg2Of lymphomas,distinguished
R1248 T1628 T1627 arg2Of growth,enhanced
R1249 T1628 T1629 arg1Of growth,of
R1250 T1600 T1598 arg2Of distinguished,were
R1251 T1600 T1599 arg1Of distinguished,also
R1252 T1632 T1633 arg1Of transgenic,and
R1253 T1603 T1602 arg1Of activation,constitutive
R1254 T1603 T1604 arg1Of activation,of
R1255 T1603 T1606 arg1Of activation,and
R1256 T1605 T1604 arg2Of Stat3,of
R1257 T1606 T1600 arg1Of and,distinguished
R1258 T1606 T1601 arg2Of and,by
R1259 T1634 T1633 arg2Of malignant,and
R1260 T1607 T1606 arg2Of deregulation,and
R1261 T1607 T1608 arg1Of deregulation,of
R1262 T1635 T1629 arg2Of lymphocytes,of
R1263 T1613 T1608 arg2Of pathway,of
R1264 T1613 T1609 arg1Of pathway,the
R1265 T1613 T1610 arg1Of pathway,Rb
R1266 T1613 T1611 arg1Of pathway,cell
R1267 T1613 T1612 arg1Of pathway,cycle
R1268 T1614 T1615 arg1Of Inhibition,of
R1269 T1614 T1625 arg1Of Inhibition,blocked
R1270 T1635 T1630 arg1Of lymphocytes,both
R1271 T1635 T1631 arg1Of lymphocytes,LMP1
R1272 T1617 T1618 arg1Of PI3K/Akt,","
R1273 T1635 T1632 arg1Of lymphocytes,transgenic
R1274 T1618 T1621 arg1Of ",",and
R1275 T1635 T1634 arg1Of lymphocytes,malignant
R1276 T1619 T1618 arg2Of NFκB,","
R1277 T1637 T1625 arg3Of suggesting,blocked
R1278 T1621 T1620 arg1Of and,","
R1279 T1622 T1621 arg2Of Stat3,and
R1280 T1640 T1639 arg1Of pathways,these
R1281 T1624 T1615 arg2Of pathways,of
R1282 T1624 T1616 arg1Of pathways,the
R1283 T1624 T1617 arg1Of pathways,PI3K/Akt
R1284 T1624 T1619 arg1Of pathways,NFκB
R1285 T1624 T1622 arg1Of pathways,Stat3
R1286 T1624 T1623 arg1Of pathways,signaling
R1287 T1625 T1636 arg1Of blocked,","
R1288 T1640 T1641 arg1Of pathways,are
R1289 T1640 T1642 arg2Of pathways,required
R1290 T1642 T1637 arg2Of required,suggesting
R1291 T1642 T1638 arg1Of required,that
R1292 T1642 T1641 arg2Of required,are
R1293 T1642 T1643 arg1Of required,for
R1294 T1645 T1646 arg1Of growth,and
R1295 T1646 T1643 arg2Of and,for
R1296 T1646 T1644 arg1Of and,their
R1297 T1647 T1646 arg2Of survival,and
R1299 T1648 T1649 arg1Of These,appear
R1302 T1648 T1651 arg1Of These,be
R1303 T1651 T1649 arg2Of be,appear
R1304 T1651 T1650 arg1Of be,to
R1305 T1654 T1651 arg2Of targets,be
R1306 T1654 T1652 arg1Of targets,the
R1307 T1654 T1653 arg1Of targets,same
R1308 T1654 T1655 arg1Of targets,that
R1309 T1654 T1656 arg1Of targets,are
R1310 T1654 T1657 arg2Of targets,deregulated
R1311 T1657 T1656 arg2Of deregulated,are
R1312 T1657 T1658 arg1Of deregulated,in
R1313 T1661 T1658 arg2Of lymphomas,in
R1314 T1661 T1659 arg1Of lymphomas,wild-type
R1315 T1661 T1660 arg1Of lymphomas,B-1a
R1316 T1661 T1662 arg1Of lymphomas,that
R1317 T1661 T1663 arg1Of lymphomas,arise
R1318 T1663 T1664 arg1Of arise,spontaneously
R1319 T1663 T1665 arg1Of arise,through
R1320 T1667 T1665 arg2Of predisposition,through
R1321 T1667 T1666 arg1Of predisposition,age
R1322 T1669 T1668 arg1Of study,This
R1323 T1669 T1670 arg1Of study,reveals
R1324 T1672 T1673 arg1Of LMP1,promotes
R1325 T1673 T1671 arg1Of promotes,that
R1326 T1673 T1683 arg1Of promotes,and
R1327 T1674 T1673 arg2Of malignancy,promotes
R1328 T1674 T1675 arg1Of malignancy,in
R1329 T1676 T1675 arg2Of cells,in
R1330 T1676 T1677 arg1Of cells,with
R1331 T1680 T1677 arg2Of ability,with
R1332 T1680 T1678 arg1Of ability,the
R1333 T1680 T1679 arg1Of ability,inherent
R1334 T1680 T1681 modOf ability,to
R1335 T1682 T1681 arg1Of proliferate,to
R1336 T1683 T1670 arg2Of and,reveals
R1337 T1684 T1683 arg2Of that,and
R1338 T1686 T1687 arg1Of Akt,","
R1339 T1687 T1690 arg1Of ",",and
R1340 T1688 T1687 arg2Of NFκB,","
R1341 T1690 T1689 arg1Of and,","
R1342 T1691 T1690 arg2Of Stat3,and
R1344 T1693 T1685 arg1Of pathways,the
R1349 T1693 T1686 arg1Of pathways,Akt
R1352 T1693 T1688 arg1Of pathways,NFκB
R1354 T1693 T1691 arg1Of pathways,Stat3
R1357 T1693 T1692 arg1Of pathways,signaling
R1359 T1693 T1694 arg1Of pathways,are
R1361 T1693 T1695 arg2Of pathways,required
R1363 T1695 T1684 arg2Of required,that
R1368 T1695 T1694 arg2Of required,are
R1369 T1695 T1696 arg1Of required,for
R1371 T1700 T1696 arg2Of effects,for
R1381 T1700 T1697 arg1Of effects,its
R1383 T1700 T1698 arg1Of effects,growth
R1385 T1700 T1699 arg1Of effects,stimulatory
R2472 T3223 T3222 arg1Of Levels,High
R2473 T3223 T3224 arg1Of Levels,of
R2474 T3223 T3227 arg1Of Levels,Correlates
R2475 T3226 T3224 arg2Of Expression,of
R2476 T3226 T3225 arg1Of Expression,LMP1
R2477 T3227 T3228 arg1Of Correlates,with
R2478 T3230 T3228 arg2Of Development,with
R2479 T3230 T3229 arg1Of Development,the
R2480 T3230 T3231 arg1Of Development,of
R2481 T3232 T3231 arg2Of Lymphoma,of
R2482 T3234 T3233 arg1Of expression,LMP1
R2483 T3234 T3235 arg1Of expression,in
R2484 T3234 T3238 arg1Of expression,was
R2485 T3234 T3239 arg2Of expression,directed
R2486 T3237 T3235 arg2Of mice,in
R2487 T3237 T3236 arg1Of mice,IgLMP1
R2488 T3239 T3238 arg2Of directed,was
R2489 T3239 T3240 arg1Of directed,to
R2490 T3239 T3243 arg1Of directed,under
R2491 T3242 T3240 arg2Of cells,to
R2492 T3242 T3241 arg1Of cells,B
R2493 T3245 T3243 arg2Of control,under
R2494 T3245 T3244 arg1Of control,the
R2495 T3245 T3246 arg1Of control,of
R2496 T3251 T3247 arg1Of promoter,the
R2497 T3251 T3248 arg1Of promoter,Ig
R2498 T3251 T3249 arg1Of promoter,heavy
R2499 T3251 T3250 arg1Of promoter,chain
R2500 T3251 T3252 arg1Of promoter,and
R2501 T3252 T3246 arg2Of and,of
R2502 T3253 T3252 arg2Of enhancer,and
R2503 T3254 T3255 arg1Of It,has
R2504 T3254 T3257 arg1Of It,been
R2505 T3254 T3258 arg2Of It,shown
R2506 T3258 T3255 arg2Of shown,has
R2507 T3258 T3256 arg1Of shown,previously
R2508 T3258 T3257 arg2Of shown,been
R2509 T3263 T3260 arg2Of mice,in
R2510 T3263 T3261 arg1Of mice,these
R2511 T3263 T3262 arg1Of mice,transgenic
R2512 T3266 T3265 arg1Of expression,LMP1
R2513 T3266 T3267 arg1Of expression,was
R2514 T3266 T3268 arg1Of expression,restricted
R2515 T3267 T3258 arg3Of was,shown
R2516 T3267 T3259 arg1Of was,that
R2517 T3267 T3260 arg1Of was,in
R2518 T3267 T3264 arg1Of was,","
R2519 T3268 T3267 arg2Of restricted,was
R2520 T3268 T3269 arg1Of restricted,to
R2521 T3272 T3269 arg2Of cells,to
R2522 T3272 T3270 arg1Of cells,B220+
R2523 T3272 T3271 arg1Of cells,B
R2524 T3272 T3273 arg1Of cells,with
R2525 T3274 T3273 arg2Of lymphoma,with
R2526 T3274 T3275 arg2Of lymphoma,detected
R2527 T3275 T3276 arg1Of detected,in
R2528 T3278 T3277 arg1Of enlarged,greatly
R2529 T3279 T3276 arg2Of spleens,in
R2530 T3279 T3278 arg1Of spleens,enlarged
R2531 T3279 T3280 arg1Of spleens,[
R2532 T3281 T3280 arg2Of "23,26",[
R2533 T3282 T3280 arg3Of ],[
R2534 T3284 T3283 arg1Of investigate,To
R2535 T3287 T3286 arg1Of expression,LMP1
R2536 T3287 T3288 arg1Of expression,contributes
R2537 T3288 T3284 arg2Of contributes,investigate
R2538 T3288 T3285 arg1Of contributes,whether
R2539 T3288 T3289 arg1Of contributes,to
R2540 T3291 T3289 arg2Of development,to
R2541 T3291 T3290 arg1Of development,lymphoma
R2542 T3294 T3284 arg1Of cells,investigate
R2543 T3294 T3293 arg1Of cells,B
R2544 T3294 T3295 arg1Of cells,were
R2545 T3294 T3296 arg2Of cells,purified
R2546 T3296 T3295 arg2Of purified,were
R2547 T3296 T3297 arg1Of purified,from
R2548 T3296 T3308 arg1Of purified,and
R2549 T3298 T3297 arg2Of splenocytes,from
R2550 T3301 T3296 arg1Of selection,purified
R2551 T3301 T3299 arg2Of selection,by
R2552 T3301 T3300 arg1Of selection,positive
R2553 T3301 T3302 arg1Of selection,using
R2554 T3306 T3302 arg2Of beads,using
R2555 T3306 T3303 arg1Of beads,anti-CD19
R2556 T3306 T3304 arg1Of beads,MACS
R2557 T3306 T3305 arg1Of beads,magnetic
R2558 T3308 T3283 modOf and,To
R2559 T3308 T3292 arg1Of and,","
R2560 T3308 T3307 arg1Of and,","
R2561 T3310 T3309 arg1Of amounts,equivalent
R2562 T3310 T3311 arg1Of amounts,of
R2563 T3310 T3314 arg1Of amounts,were
R2564 T3310 T3315 arg2Of amounts,analyzed
R2565 T3313 T3311 arg2Of cells,of
R2566 T3313 T3312 arg1Of cells,B
R2567 T3315 T3308 arg2Of analyzed,and
R2568 T3315 T3314 arg2Of analyzed,were
R2569 T3317 T3315 arg1Of immunoblotting,analyzed
R2570 T3317 T3316 arg2Of immunoblotting,by
R2571 T3318 T3319 arg1Of LMP1,was
R2572 T3318 T3320 arg1Of LMP1,detectable
R2573 T3319 T3327 arg1Of was,but
R2574 T3320 T3319 arg2Of detectable,was
R2575 T3320 T3321 arg1Of detectable,in
R2576 T3325 T3321 arg2Of cells,in
R2577 T3325 T3322 arg1Of cells,LMP1
R2578 T3325 T3323 arg1Of cells,transgenic
R2579 T3325 T3324 arg1Of cells,B
R2580 T3327 T3326 arg1Of but,","
R2581 T3329 T3328 arg2Of development,upon
R2582 T3329 T3330 arg1Of development,of
R2583 T3331 T3330 arg2Of lymphoma,of
R2584 T3334 T3333 arg1Of expression,LMP1
R2585 T3334 T3335 arg1Of expression,was
R2586 T3334 T3336 arg1Of expression,stronger
R2587 T3335 T3327 arg2Of was,but
R2588 T3335 T3328 arg1Of was,upon
R2589 T3335 T3332 arg1Of was,","
R2590 T3336 T3335 arg2Of stronger,was
R2591 T3336 T3337 arg1Of stronger,in
R2592 T3339 T3337 arg2Of lymphomas,in
R2593 T3339 T3338 arg1Of lymphomas,5/7
R2594 T3339 T3340 arg2Of lymphomas,analyzed
R2595 T3340 T3341 arg1Of analyzed,with
R2596 T3343 T3341 arg2Of appearance,with
R2597 T3343 T3342 arg1Of appearance,concomitant
R2598 T3343 T3344 arg1Of appearance,of
R2599 T3346 T3344 arg2Of products,of
R2600 T3346 T3345 arg1Of products,degradation
R2601 T3346 T3347 arg1Of products,(
R2602 T3349 T3347 arg2Of 1A,(
R2603 T3349 T3348 arg1Of 1A,Figure
R2604 T3350 T3347 arg3Of ),(
R2605 T3352 T3351 arg1Of determine,To
R2606 T3356 T3354 arg1Of level,the
R2607 T3356 T3355 arg1Of level,higher
R2608 T3356 T3357 arg1Of level,of
R2609 T3356 T3360 arg1Of level,was
R2610 T3356 T3361 arg1Of level,due
R2611 T3358 T3357 arg2Of LMP1,of
R2612 T3358 T3359 arg2Of LMP1,detected
R2613 T3360 T3352 arg2Of was,determine
R2614 T3360 T3353 arg1Of was,whether
R2615 T3361 T3360 arg2Of due,was
R2616 T3361 T3362 arg1Of due,to
R2617 T3364 T3362 arg2Of expansion,to
R2618 T3364 T3363 arg1Of expansion,an
R2619 T3364 T3365 arg1Of expansion,of
R2620 T3367 T3365 arg2Of lymphocytes,of
R2621 T3367 T3366 arg1Of lymphocytes,malignant
R2622 T3369 T3370 arg1Of expression,of
R2623 T3369 T3372 arg1Of expression,in
R2624 T3369 T3375 arg1Of expression,was
R2625 T3369 T3377 arg2Of expression,evaluated
R2626 T3371 T3370 arg2Of LMP1,of
R2627 T3374 T3372 arg2Of spleen,in
R2628 T3374 T3373 arg1Of spleen,the
R2629 T3377 T3351 modOf evaluated,To
R2630 T3377 T3368 arg1Of evaluated,","
R2631 T3377 T3375 arg2Of evaluated,was
R2632 T3377 T3376 arg1Of evaluated,further
R2633 T3377 T3378 arg1Of evaluated,by
R2634 T3380 T3378 arg2Of staining,by
R2635 T3380 T3379 arg1Of staining,immunohistochemical
R2636 T3382 T3381 arg1Of analysis,Immunohistochemistry
R2637 T3382 T3383 arg1Of analysis,of
R2638 T3382 T3386 arg1Of analysis,detected
R2639 T3385 T3383 arg2Of sections,of
R2640 T3385 T3384 arg1Of sections,spleen
R2641 T3386 T3388 arg1Of detected,in
R2642 T3387 T3386 arg2Of LMP1,detected
R2643 T3391 T3388 arg2Of membrane,in
R2644 T3391 T3389 arg1Of membrane,the
R2645 T3391 T3390 arg1Of membrane,plasma
R2646 T3391 T3392 arg1Of membrane,of
R2647 T3391 T3394 arg1Of membrane,in
R2648 T3393 T3392 arg2Of cells,of
R2649 T3399 T3397 arg1Of pulp,follicular
R2650 T3399 T3398 arg1Of pulp,white
R2651 T3399 T3400 arg1Of pulp,and
R2652 T3400 T3394 arg2Of and,in
R2653 T3400 T3395 arg1Of and,both
R2654 T3400 T3396 arg1Of and,the
R2655 T3400 T3403 arg1Of and,in
R2656 T3402 T3400 arg2Of lymphocytes,and
R2657 T3402 T3401 arg1Of lymphocytes,circulating
R2658 T3406 T3403 arg2Of pulp,in
R2659 T3406 T3404 arg1Of pulp,the
R2660 T3406 T3405 arg1Of pulp,red
R2661 T3406 T3407 arg1Of pulp,(
R2662 T3409 T3407 arg2Of 1B,(
R2663 T3409 T3408 arg1Of 1B,Figure
R2664 T3410 T3407 arg3Of ),(
R2665 T3412 T3411 arg1Of expression,LMP1
R2666 T3412 T3413 arg1Of expression,was
R2667 T3412 T3414 arg1Of expression,heterogeneous
R2668 T3414 T3413 arg2Of heterogeneous,was
R2669 T3414 T3415 arg1Of heterogeneous,with
R2670 T3418 T3415 arg2Of staining,with
R2671 T3418 T3416 arg1Of staining,strong
R2672 T3418 T3417 arg1Of staining,LMP1
R2673 T3418 T3419 arg2Of staining,interspersed
R2674 T3419 T3420 arg1Of interspersed,amongst
R2675 T3422 T3420 arg2Of background,amongst
R2676 T3422 T3421 arg1Of background,a
R2677 T3422 T3423 arg1Of background,of
R2678 T3424 T3423 arg2Of cells,of
R2679 T3424 T3425 arg1Of cells,staining
R2680 T3425 T3426 arg1Of staining,weakly
R2681 T3425 T3427 arg1Of staining,for
R2682 T3428 T3427 arg2Of LMP1,for
R2683 T3430 T3429 arg2Of development,Upon
R2684 T3430 T3431 arg1Of development,to
R2685 T3432 T3431 arg2Of lymphoma,to
R2686 T3435 T3434 arg1Of expression,LMP1
R2687 T3435 T3436 arg1Of expression,was
R2688 T3435 T3439 arg2Of expression,detected
R2689 T3438 T3437 arg1Of abundantly,more
R2690 T3439 T3429 arg1Of detected,Upon
R2691 T3439 T3433 arg1Of detected,","
R2692 T3439 T3436 arg2Of detected,was
R2693 T3439 T3438 arg1Of detected,abundantly
R2694 T3439 T3440 arg1Of detected,with
R2695 T3442 T3440 arg2Of foci,with
R2696 T3442 T3441 arg1Of foci,multiple
R2697 T3442 T3443 arg1Of foci,of
R2698 T3446 T3443 arg2Of staining,of
R2699 T3446 T3444 arg1Of staining,intense
R2700 T3446 T3445 arg1Of staining,LMP1
R2701 T3447 T3448 arg1Of This,demonstrates
R2702 T3452 T3450 arg1Of LMP1,the
R2703 T3452 T3451 arg2Of LMP1,increased
R2704 T3452 T3453 arg2Of LMP1,detected
R2705 T3452 T3459 arg1Of LMP1,reflects
R2706 T3455 T3453 arg1Of immunoblotting,detected
R2707 T3455 T3454 arg2Of immunoblotting,by
R2708 T3455 T3456 arg1Of immunoblotting,upon
R2709 T3458 T3456 arg2Of progression,upon
R2710 T3458 T3457 arg1Of progression,malignant
R2711 T3459 T3448 arg2Of reflects,demonstrates
R2712 T3459 T3449 arg1Of reflects,that
R2713 T3461 T3460 arg1Of increase,an
R2714 T3461 T3462 arg1Of increase,in
R2715 T3461 T3465 arg1Of increase,and
R2716 T3464 T3462 arg2Of expression,in
R2717 T3464 T3463 arg1Of expression,LMP1
R2718 T3465 T3459 arg2Of and,reflects
R2719 T3467 T3465 arg2Of accumulation,and
R2720 T3467 T3466 arg1Of accumulation,an
R2721 T3467 T3468 arg1Of accumulation,of
R2722 T3469 T3468 arg2Of cells,of
R2723 T3469 T3470 arg1Of cells,expressing
R2724 T3472 T3470 arg2Of levels,expressing
R2725 T3472 T3471 arg1Of levels,high
R2726 T3472 T3473 arg1Of levels,of
R2727 T3474 T3473 arg2Of LMP1,of
R2728 T3476 T3475 arg1Of correlation,This
R2729 T3476 T3477 arg1Of correlation,between
R2730 T3476 T3486 arg1Of correlation,suggests
R2731 T3480 T3478 arg1Of expression,high
R2732 T3480 T3479 arg1Of expression,LMP1
R2733 T3480 T3481 arg1Of expression,and
R2734 T3481 T3477 arg2Of and,between
R2735 T3483 T3481 arg2Of development,and
R2736 T3483 T3482 arg1Of development,the
R2737 T3483 T3484 arg1Of development,of
R2738 T3485 T3484 arg2Of lymphoma,of
R2739 T3486 T3492 arg1Of suggests,from
R2740 T3488 T3489 arg1Of progression,to
R2741 T3488 T3491 arg1Of progression,results
R2742 T3490 T3489 arg2Of lymphoma,to
R2743 T3491 T3486 arg2Of results,suggests
R2744 T3491 T3487 arg1Of results,that
R2745 T3494 T3492 arg2Of levels,from
R2746 T3494 T3493 arg2Of levels,increased
R2747 T3494 T3495 arg1Of levels,of
R2748 T3496 T3495 arg2Of LMP1,of
R3168 T4142 T4140 arg2Of lymphomas,immunophenotype
R3169 T4142 T4141 arg1Of lymphomas,the
R3170 T4142 T4143 arg1Of lymphomas,that
R3171 T4142 T4144 arg1Of lymphomas,arise
R3172 T4144 T4145 arg1Of arise,from
R3173 T4147 T4145 arg2Of expression,from
R3174 T4147 T4146 arg1Of expression,LMP1
R3175 T4151 T4149 arg1Of expression,surface
R3176 T4151 T4150 arg1Of expression,Ig
R3177 T4151 T4152 arg1Of expression,of
R3178 T4151 T4167 arg1Of expression,","
R3179 T4151 T4170 arg1Of expression,were
R3180 T4151 T4171 arg2Of expression,analyzed
R3181 T4154 T4153 arg1Of chains,heavy
R3182 T4154 T4155 arg1Of chains,(
R3183 T4154 T4162 arg1Of chains,and
R3184 T4156 T4155 arg2Of IgM,(
R3185 T4156 T4157 arg1Of IgM,","
R3186 T4156 T4159 arg1Of IgM,","
R3187 T4158 T4157 arg2Of IgG,","
R3188 T4160 T4159 arg2Of IgD,","
R3189 T4161 T4155 arg3Of ),(
R3190 T4162 T4152 arg2Of and,of
R3191 T4164 T4162 arg2Of chains,and
R3192 T4164 T4163 arg1Of chains,light
R3193 T4164 T4166 arg1Of chains,κ
R3194 T4166 T4165 arg1Of κ,(
R3195 T4168 T4169 arg1Of λ,)
R3198 T4171 T4148 arg1Of analyzed,","
R3199 T4171 T4168 arg1Of analyzed,λ
R3200 T4171 T4170 arg2Of analyzed,were
R3201 T4174 T4171 arg1Of cytometry,analyzed
R3202 T4174 T4172 arg2Of cytometry,by
R3203 T4174 T4173 arg1Of cytometry,flow
R3204 T4176 T4175 arg1Of numbers,Similar
R3205 T4176 T4177 arg1Of numbers,of
R3206 T4176 T4185 arg1Of numbers,with
R3207 T4176 T4193 arg1Of numbers,were
R3208 T4176 T4194 arg2Of numbers,detected
R3209 T4180 T4179 arg2Of IgM+IgD+IgG−,(
R3210 T4181 T4179 arg3Of ),(
R3211 T4184 T4177 arg2Of cells,of
R3212 T4184 T4178 arg1Of cells,naïve
R3213 T4184 T4179 arg1Of cells,(
R3214 T4184 T4182 arg1Of cells,splenic
R3215 T4184 T4183 arg1Of cells,B
R3216 T4188 T4185 arg2Of bias,with
R3217 T4188 T4186 arg1Of bias,a
R3218 T4188 T4187 arg1Of bias,strong
R3219 T4188 T4189 arg1Of bias,towards
R3220 T4192 T4189 arg2Of chain,towards
R3221 T4192 T4190 arg1Of chain,κ
R3222 T4192 T4191 arg1Of chain,light
R3223 T4194 T4193 arg2Of detected,were
R3224 T4194 T4195 arg1Of detected,from
R3225 T4194 T4201 arg1Of detected,","
R3226 T4194 T4202 modOf detected,indicating
R3227 T4196 T4197 arg1Of wild-type,or
R3228 T4197 T4195 arg2Of or,from
R3229 T4200 T4197 arg2Of mice,or
R3230 T4200 T4198 arg1Of mice,LMP1
R3231 T4200 T4199 arg1Of mice,transgenic
R3232 T4205 T4204 arg1Of signaling,LMP1
R3233 T4205 T4206 arg1Of signaling,does
R3234 T4205 T4208 arg1Of signaling,affect
R3235 T4208 T4202 arg2Of affect,indicating
R3236 T4208 T4203 arg1Of affect,that
R3237 T4208 T4206 arg2Of affect,does
R3238 T4208 T4207 arg1Of affect,not
R3239 T4211 T4208 arg2Of maturation,affect
R3240 T4211 T4209 arg1Of maturation,B
R3241 T4211 T4210 arg1Of maturation,cell
R3242 T4211 T4212 arg1Of maturation,(
R3243 T4214 T4212 arg2Of data,(
R3244 T4214 T4213 arg1Of data,unpublished
R3245 T4215 T4212 arg3Of ),(
R3246 T4218 T4216 arg1Of analysis,Flow
R3247 T4218 T4217 arg1Of analysis,cytometry
R3248 T4218 T4219 arg1Of analysis,of
R3249 T4218 T4227 arg1Of analysis,revealed
R3250 T4222 T4221 arg1Of wild-type,SCID-passaged
R3251 T4222 T4223 arg1Of wild-type,and
R3252 T4223 T4219 arg2Of and,of
R3253 T4223 T4220 arg1Of and,the
R3254 T4226 T4223 arg2Of lymphomas,and
R3255 T4226 T4224 arg1Of lymphomas,LMP1
R3256 T4226 T4225 arg1Of lymphomas,transgenic
R3257 T4230 T4229 arg1Of phenotype,IgMhighIgDlow
R3258 T4230 T4231 arg1Of phenotype,(
R3259 T4230 T4235 arg1Of phenotype,","
R3260 T4230 T4236 arg1Of phenotype,indicative
R3261 T4230 T4240 arg1Of phenotype,","
R3262 T4233 T4231 arg2Of 2A,(
R3263 T4233 T4232 arg1Of 2A,Figure
R3264 T4234 T4231 arg3Of ),(
R3265 T4236 T4237 arg1Of indicative,of
R3266 T4239 T4237 arg2Of zone,of
R3267 T4239 T4238 arg1Of zone,marginal
R3268 T4240 T4243 arg1Of ",",or
R3269 T4241 T4240 arg2Of B-1,","
R3270 T4243 T4227 arg2Of or,revealed
R3271 T4243 T4228 arg1Of or,an
R3272 T4243 T4242 arg1Of or,","
R3273 T4246 T4243 arg2Of cells,or
R3274 T4246 T4244 arg1Of cells,memory
R3275 T4246 T4245 arg1Of cells,B
R3276 T4248 T4247 arg1Of cells,B-1
R3277 T4248 T4249 arg1Of cells,are
R3278 T4248 T4251 arg2Of cells,separated
R3279 T4251 T4249 arg2Of separated,are
R3280 T4251 T4250 arg1Of separated,further
R3281 T4251 T4252 arg1Of separated,into
R3282 T4253 T4254 arg1Of CD5+,(
R3283 T4253 T4257 arg1Of CD5+,and
R3284 T4255 T4254 arg2Of B-1a,(
R3285 T4256 T4254 arg3Of ),(
R3286 T4257 T4252 arg2Of and,into
R3287 T4260 T4259 arg2Of B-1b,(
R3288 T4261 T4259 arg3Of ),(
R3289 T4262 T4257 arg2Of subsets,and
R3290 T4262 T4258 arg1Of subsets,CD5−
R3291 T4262 T4259 arg1Of subsets,(
R3292 T4264 T4263 arg1Of differentiate,To
R3293 T4264 T4265 arg1Of differentiate,between
R3294 T4268 T4265 arg2Of types,between
R3295 T4268 T4266 arg1Of types,these
R3296 T4268 T4267 arg1Of types,cell
R3297 T4271 T4264 arg1Of cells,differentiate
R3298 T4271 T4270 arg1Of cells,lymphoma
R3299 T4271 T4272 arg1Of cells,were
R3300 T4271 T4274 arg2Of cells,analyzed
R3301 T4274 T4263 modOf analyzed,To
R3302 T4274 T4269 arg1Of analyzed,","
R3303 T4274 T4272 arg2Of analyzed,were
R3304 T4274 T4273 arg1Of analyzed,further
R3305 T4274 T4275 arg1Of analyzed,for
R3306 T4279 T4275 arg2Of CD5,for
R3307 T4279 T4276 arg1Of CD5,the
R3308 T4279 T4277 arg1Of CD5,B-1a
R3309 T4279 T4278 arg1Of CD5,marker
R3310 T4282 T4280 arg1Of 5/5,All
R3311 T4282 T4281 arg2Of 5/5,(
R3312 T4282 T4284 arg1Of 5/5,of
R3313 T4282 T4290 arg1Of 5/5,displayed
R3314 T4283 T4281 arg3Of ),(
R3315 T4289 T4284 arg2Of lymphomas,of
R3316 T4289 T4285 arg1Of lymphomas,the
R3317 T4289 T4286 arg2Of lymphomas,tested
R3318 T4289 T4287 arg1Of lymphomas,LMP1
R3319 T4289 T4288 arg1Of lymphomas,transgenic
R3320 T4293 T4290 arg2Of phenotype,displayed
R3321 T4293 T4291 arg1Of phenotype,an
R3322 T4293 T4292 arg1Of phenotype,IgMhighIgDlowCD5+
R3323 T4293 T4294 arg1Of phenotype,(
R3324 T4293 T4298 arg1Of phenotype,","
R3325 T4296 T4294 arg2Of 2A,(
R3326 T4296 T4295 arg1Of 2A,Figure
R3327 T4297 T4294 arg3Of ),(
R3328 T4301 T4298 arg2Of pattern,","
R3329 T4301 T4299 arg1Of pattern,an
R3330 T4301 T4300 arg1Of pattern,expression
R3331 T4301 T4302 arg1Of pattern,that
R3332 T4301 T4303 arg1Of pattern,distinguishes
R3333 T4305 T4303 arg2Of cells,distinguishes
R3334 T4305 T4304 arg1Of cells,B-1a
R3335 T4311 T4308 arg1Of lymphoma,a
R3336 T4311 T4309 arg1Of lymphoma,spontaneous
R3337 T4311 T4310 arg1Of lymphoma,wild-type
R3338 T4311 T4313 arg1Of lymphoma,developed
R3339 T4313 T4306 arg1Of developed,Interestingly
R3340 T4313 T4307 arg1Of developed,","
R3341 T4313 T4312 arg1Of developed,also
R3342 T4313 T4314 arg1Of developed,in
R3343 T4316 T4314 arg2Of cells,in
R3344 T4316 T4315 arg1Of cells,B-1a
R3345 T4316 T4317 arg1Of cells,(
R3346 T4319 T4317 arg2Of 2A,(
R3347 T4319 T4318 arg1Of 2A,Figure
R3348 T4320 T4317 arg3Of ),(
R3349 T4322 T4321 arg1Of cells,These
R3350 T4322 T4323 arg1Of cells,are
R3351 T4323 T4330 modOf are,replenishing
R3352 T4326 T4323 arg2Of population,are
R3353 T4326 T4324 arg1Of population,an
R3354 T4326 T4325 arg1Of population,interesting
R3355 T4326 T4327 arg1Of population,that
R3356 T4326 T4328 arg1Of population,is
R3357 T4329 T4328 arg2Of self,is
R3358 T4330 T4331 arg1Of replenishing,with
R3359 T4330 T4335 modOf replenishing,to
R3360 T4330 T4341 arg1Of replenishing,[
R3361 T4334 T4331 arg2Of likelihood,with
R3362 T4334 T4332 arg1Of likelihood,an
R3363 T4334 T4333 arg2Of likelihood,increased
R3364 T4336 T4335 arg1Of become,to
R3365 T4336 T4338 arg1Of become,in
R3366 T4337 T4336 arg2Of malignant,become
R3367 T4340 T4338 arg2Of mice,in
R3368 T4340 T4339 arg1Of mice,aged
R3369 T4342 T4341 arg2Of 30,[
R3370 T4343 T4341 arg3Of ],[
R3371 T4344 T4345 arg1Of Analysis,of
R3372 T4344 T4354 arg1Of Analysis,showed
R3373 T4348 T4345 arg2Of mice,of
R3374 T4348 T4346 arg1Of mice,LMP1
R3375 T4348 T4347 arg1Of mice,transgenic
R3376 T4348 T4349 arg1Of mice,before
R3377 T4351 T4349 arg2Of development,before
R3378 T4351 T4350 arg1Of development,the
R3379 T4351 T4352 arg1Of development,of
R3380 T4353 T4352 arg2Of lymphoma,of
R3381 T4354 T4371 arg1Of showed,","
R3382 T4354 T4372 modOf showed,indicating
R3383 T4356 T4354 arg2Of numbers,showed
R3384 T4356 T4355 arg1Of numbers,similar
R3385 T4356 T4357 arg1Of numbers,of
R3386 T4359 T4360 arg1Of B-1a,(
R3387 T4359 T4363 arg1Of B-1a,and
R3388 T4361 T4360 arg2Of CD19+CD5+,(
R3389 T4362 T4360 arg3Of ),(
R3390 T4364 T4365 arg1Of B-1b,or
R3391 T4365 T4363 arg2Of or,and
R3392 T4366 T4365 arg2Of B-2,or
R3393 T4367 T4357 arg2Of populations,of
R3394 T4367 T4358 arg1Of populations,splenic
R3395 T4367 T4359 arg1Of populations,B-1a
R3396 T4367 T4364 arg1Of populations,B-1b
R3397 T4367 T4366 arg1Of populations,B-2
R3398 T4367 T4368 arg1Of populations,(
R3399 T4369 T4368 arg2Of CD19+CD5−,(
R3400 T4370 T4368 arg3Of ),(
R3401 T4374 T4375 arg1Of LMP1,does
R3402 T4374 T4377 arg1Of LMP1,affect
R3403 T4377 T4372 arg2Of affect,indicating
R3404 T4377 T4373 arg1Of affect,that
R3405 T4377 T4375 arg2Of affect,does
R3406 T4377 T4376 arg1Of affect,not
R3407 T4380 T4377 arg2Of differentiation,affect
R3408 T4380 T4378 arg1Of differentiation,B
R3409 T4380 T4379 arg1Of differentiation,cell
R3410 T4380 T4381 arg1Of differentiation,(
R3411 T4383 T4381 arg2Of 2B,(
R3412 T4383 T4382 arg1Of 2B,Figure
R3413 T4384 T4381 arg3Of ),(
R3414 T4386 T4385 arg1Of to,Due
R3415 T4388 T4386 arg2Of exclusion,to
R3416 T4388 T4387 arg1Of exclusion,allelic
R3417 T4392 T4390 arg1Of cells,mature
R3418 T4392 T4391 arg1Of cells,B
R3419 T4392 T4393 arg1Of cells,that
R3420 T4392 T4394 arg1Of cells,have
R3421 T4392 T4395 arg1Of cells,been
R3422 T4392 T4396 arg2Of cells,exposed
R3423 T4392 T4399 arg1Of cells,will
R3424 T4392 T4401 arg1Of cells,express
R3425 T4392 T4420 arg1Of cells,λ
R3426 T4396 T4394 arg2Of exposed,have
R3427 T4396 T4395 arg2Of exposed,been
R3428 T4396 T4397 arg1Of exposed,to
R3429 T4398 T4397 arg2Of antigen,to
R3430 T4401 T4419 arg1Of express,or
R3431 T4403 T4402 arg1Of one,only
R3432 T4406 T4403 arg1Of isotype,one
R3433 T4406 T4404 arg1Of isotype,heavy
R3434 T4406 T4405 arg1Of isotype,chain
R3435 T4406 T4407 arg1Of isotype,(
R3436 T4406 T4415 arg1Of isotype,and
R3437 T4408 T4409 arg1Of IgG,","
R3438 T4409 T4412 arg1Of ",",or
R3439 T4410 T4409 arg2Of IgE,","
R3440 T4412 T4407 arg2Of or,(
R3441 T4412 T4411 arg1Of or,","
R3442 T4413 T4412 arg2Of IgA,or
R3443 T4414 T4407 arg3Of ),(
R3444 T4415 T4401 arg2Of and,express
R3445 T4418 T4415 arg2Of κ,and
R3446 T4418 T4416 arg1Of κ,either
R3447 T4418 T4417 arg1Of κ,a
R3448 T4419 T4386 arg1Of or,to
R3449 T4419 T4389 arg1Of or,","
R3450 T4419 T4399 arg2Of or,will
R3451 T4419 T4400 arg1Of or,typically
R3452 T4420 T4419 arg2Of λ,or
R3453 T4422 T4420 arg2Of chain,λ
R3454 T4422 T4421 arg1Of chain,light
R3455 T4428 T4425 arg1Of lymphomas,2/5
R3456 T4428 T4426 arg1Of lymphomas,LMP1
R3457 T4428 T4427 arg1Of lymphomas,transgenic
R3458 T4428 T4429 arg2Of lymphomas,analyzed
R3459 T4428 T4436 arg1Of lymphomas,were
R3460 T4428 T4438 arg1Of lymphomas,positive
R3461 T4428 T4446 arg1Of lymphomas,λ
R3462 T4429 T4430 arg1Of analyzed,(
R3463 T4432 T4433 arg1Of 2,and
R3464 T4433 T4430 arg2Of and,(
R3465 T4433 T4431 arg1Of and,lymphomas
R3466 T4434 T4433 arg2Of 4,and
R3467 T4435 T4430 arg3Of ),(
R3468 T4436 T4445 arg1Of were,and
R3469 T4438 T4436 arg2Of positive,were
R3470 T4438 T4437 arg1Of positive,doubly
R3471 T4438 T4439 arg1Of positive,for
R3472 T4441 T4439 arg2Of levels,for
R3473 T4441 T4440 arg1Of levels,low
R3474 T4441 T4442 arg1Of levels,of
R3475 T4444 T4442 arg2Of κ,of
R3476 T4444 T4443 arg1Of κ,both
R3477 T4445 T4423 arg1Of and,Interestingly
R3478 T4445 T4424 arg1Of and,","
R3479 T4446 T4445 arg2Of λ,and
R3480 T4448 T4446 arg2Of chains,λ
R3481 T4448 T4447 arg1Of chains,light
R3482 T4448 T4449 arg1Of chains,(
R3483 T4451 T4449 arg2Of 2A,(
R3484 T4451 T4450 arg1Of 2A,Figure
R3485 T4452 T4449 arg3Of ),(
R3486 T4454 T4453 arg1Of characterization,Previous
R3487 T4454 T4455 arg1Of characterization,of
R3488 T4454 T4459 arg1Of characterization,had
R3489 T4454 T4460 arg1Of characterization,revealed
R3490 T4458 T4455 arg2Of lymphomas,of
R3491 T4458 T4456 arg1Of lymphomas,the
R3492 T4458 T4457 arg1Of lymphomas,LMP1
R3493 T4460 T4459 arg2Of revealed,had
R3494 T4463 T4462 arg1Of lymphomas,the
R3495 T4463 T4464 arg1Of lymphomas,were
R3496 T4463 T4465 arg1Of lymphomas,clonal
R3497 T4464 T4466 arg1Of were,as
R3498 T4464 T4473 arg1Of were,[
R3499 T4464 T4477 arg1Of were,and
R3500 T4465 T4464 arg2Of clonal,were
R3501 T4467 T4466 arg2Of determined,as
R3502 T4472 T4467 arg1Of rearrangement,determined
R3503 T4472 T4468 arg2Of rearrangement,by
R3504 T4472 T4469 arg1Of rearrangement,Ig
R3505 T4472 T4470 arg1Of rearrangement,heavy
R3506 T4472 T4471 arg1Of rearrangement,chain
R3507 T4474 T4473 arg2Of 26,[
R3508 T4475 T4473 arg3Of ],[
R3509 T4477 T4460 arg2Of and,revealed
R3510 T4477 T4461 arg1Of and,that
R3511 T4477 T4476 arg1Of and,","
R3512 T4478 T4479 arg1Of analysis,of
R3513 T4478 T4494 arg1Of analysis,confirmed
R3514 T4482 T4479 arg2Of rearrangement,of
R3515 T4482 T4480 arg1Of rearrangement,κ
R3516 T4482 T4481 arg1Of rearrangement,chain
R3517 T4482 T4483 arg1Of rearrangement,(
R3518 T4482 T4487 arg1Of rearrangement,of
R3519 T4485 T4483 arg2Of S1,(
R3520 T4485 T4484 arg1Of S1,Figure
R3521 T4486 T4483 arg3Of ),(
R3522 T4489 T4487 arg2Of samples,of
R3523 T4489 T4488 arg1Of samples,the
R3524 T4489 T4490 arg2Of samples,analyzed
R3525 T4490 T4491 arg1Of analyzed,in
R3526 T4493 T4491 arg2Of study,in
R3527 T4493 T4492 arg1Of study,this
R3528 T4494 T4477 arg2Of confirmed,and
R3529 T4495 T4494 arg2Of clonality,confirmed
R3530 T4498 T4496 arg1Of assess,To
R3531 T4498 T4497 arg1Of assess,further
R3532 T4501 T4498 arg2Of expression,assess
R3533 T4501 T4499 arg1Of expression,light
R3534 T4501 T4500 arg1Of expression,chain
R3535 T4505 T4498 arg1Of samples,assess
R3536 T4505 T4503 arg1Of samples,the
R3537 T4505 T4504 arg2Of samples,passaged
R3538 T4505 T4506 arg1Of samples,were
R3539 T4505 T4507 arg2Of samples,tested
R3540 T4505 T4513 arg1Of samples,λ
R3541 T4507 T4506 arg2Of tested,were
R3542 T4507 T4508 arg1Of tested,by
R3543 T4507 T4512 arg1Of tested,and
R3544 T4509 T4508 arg2Of immunoblotting,by
R3545 T4509 T4510 arg1Of immunoblotting,for
R3546 T4511 T4510 arg2Of κ,for
R3547 T4512 T4496 modOf and,To
R3548 T4512 T4502 arg1Of and,","
R3549 T4513 T4512 arg2Of λ,and
R3550 T4515 T4513 arg2Of chains,λ
R3551 T4515 T4514 arg1Of chains,light
R3552 T4515 T4516 arg1Of chains,(
R3553 T4518 T4516 arg2Of 2C,(
R3554 T4518 T4517 arg1Of 2C,Figure
R3555 T4519 T4516 arg3Of ),(
R3556 T4523 T4522 arg1Of low,very
R3557 T4524 T4523 arg1Of levels,low
R3558 T4524 T4525 arg1Of levels,of
R3559 T4524 T4531 arg1Of levels,were
R3560 T4524 T4532 arg2Of levels,detected
R3561 T4526 T4525 arg2Of expression,of
R3562 T4526 T4527 arg1Of expression,of
R3563 T4530 T4527 arg2Of chains,of
R3564 T4530 T4528 arg1Of chains,both
R3565 T4530 T4529 arg1Of chains,light
R3566 T4532 T4520 arg1Of detected,Interestingly
R3567 T4532 T4521 arg1Of detected,","
R3568 T4532 T4531 arg2Of detected,were
R3569 T4535 T4532 arg1Of cytometry,detected
R3570 T4535 T4533 arg2Of cytometry,by
R3571 T4535 T4534 arg1Of cytometry,flow
R3572 T4538 T4536 arg1Of levels,The
R3573 T4538 T4537 arg1Of levels,low
R3574 T4538 T4539 arg1Of levels,of
R3575 T4538 T4541 arg1Of levels,may
R3576 T4538 T4542 arg1Of levels,reflect
R3577 T4540 T4539 arg2Of expression,of
R3578 T4542 T4541 arg2Of reflect,may
R3579 T4544 T4542 arg2Of limitation,reflect
R3580 T4544 T4543 arg1Of limitation,a
R3581 T4544 T4545 arg1Of limitation,of
R3582 T4548 T4545 arg2Of number,of
R3583 T4548 T4546 arg1Of number,the
R3584 T4548 T4547 arg1Of number,total
R3585 T4548 T4549 arg1Of number,of
R3586 T4551 T4549 arg2Of chains,of
R3587 T4551 T4550 arg1Of chains,light
R3588 T4551 T4552 arg1Of chains,that
R3589 T4551 T4553 arg1Of chains,can
R3590 T4551 T4554 arg1Of chains,be
R3591 T4551 T4555 arg2Of chains,expressed
R3592 T4555 T4553 arg2Of expressed,can
R3593 T4555 T4554 arg2Of expressed,be
R3594 T4555 T4556 arg1Of expressed,on
R3595 T4558 T4556 arg2Of surface,on
R3596 T4558 T4557 arg1Of surface,the
R3597 T4558 T4559 arg1Of surface,of
R3598 T4562 T4559 arg2Of cell,of
R3599 T4562 T4560 arg1Of cell,a
R3600 T4562 T4561 arg1Of cell,B
R3601 T4563 T4565 arg1Of In,with
R3602 T4564 T4563 arg2Of agreement,In
R3603 T4569 T4563 arg3Of analysis,In
R3604 T4569 T4566 arg1Of analysis,the
R3605 T4569 T4567 arg1Of analysis,flow
R3606 T4569 T4568 arg1Of analysis,cytometry
R3607 T4573 T4571 arg1Of lymphomas,LMP1
R3608 T4573 T4572 arg1Of lymphomas,transgenic
R3609 T4574 T4575 arg1Of 2,and
R3610 T4575 T4573 arg1Of and,lymphomas
R3611 T4575 T4577 arg1Of and,were
R3612 T4575 T4579 arg1Of and,positive
R3613 T4575 T4583 arg1Of and,λ
R3614 T4576 T4575 arg2Of 4,and
R3615 T4577 T4578 arg1Of were,also
R3616 T4577 T4582 arg1Of were,and
R3617 T4579 T4577 arg2Of positive,were
R3618 T4579 T4580 arg1Of positive,for
R3619 T4581 T4580 arg2Of κ,for
R3620 T4582 T4563 arg1Of and,In
R3621 T4582 T4570 arg1Of and,","
R3622 T4583 T4582 arg2Of λ,and
R3623 T4583 T4586 arg1Of λ,by
R3624 T4583 T4593 arg1Of λ,","
R3625 T4583 T4594 modOf λ,confirming
R3626 T4585 T4583 arg2Of chains,λ
R3627 T4585 T4584 arg1Of chains,light
R3628 T4588 T4586 arg2Of analysis,by
R3629 T4588 T4587 arg1Of analysis,immunoblot
R3630 T4588 T4589 arg1Of analysis,(
R3631 T4591 T4589 arg2Of 2C,(
R3632 T4591 T4590 arg1Of 2C,Figure
R3633 T4592 T4589 arg3Of ),(
R3634 T4597 T4596 arg1Of lymphomas,these
R3635 T4597 T4598 arg1Of lymphomas,express
R3636 T4598 T4594 arg2Of express,confirming
R3637 T4598 T4595 arg1Of express,that
R3638 T4601 T4598 arg2Of chains,express
R3639 T4601 T4599 arg1Of chains,both
R3640 T4601 T4600 arg1Of chains,light
R3641 T4604 T4602 arg1Of study,A
R3642 T4604 T4603 arg1Of study,previous
R3643 T4604 T4605 arg1Of study,of
R3644 T4604 T4618 arg1Of study,determined
R3645 T4606 T4605 arg2Of mice,of
R3646 T4606 T4607 arg1Of mice,that
R3647 T4606 T4608 arg1Of mice,developed
R3648 T4608 T4611 arg1Of developed,to
R3649 T4609 T4608 arg2Of leukemia,developed
R3650 T4611 T4610 arg1Of to,due
R3651 T4613 T4611 arg2Of expansion,to
R3652 T4613 T4612 arg1Of expansion,an
R3653 T4613 T4614 arg1Of expansion,of
R3654 T4617 T4614 arg2Of cells,of
R3655 T4617 T4615 arg1Of cells,self-reactive
R3656 T4617 T4616 arg1Of cells,B-1a
R3657 T4622 T4620 arg1Of leukemias,the
R3658 T4622 T4621 arg1Of leukemias,B-1a
R3659 T4622 T4623 arg1Of leukemias,were
R3660 T4622 T4626 arg1Of leukemias,positive
R3661 T4622 T4630 arg1Of leukemias,λ
R3662 T4623 T4624 arg1Of were,also
R3663 T4623 T4629 arg1Of were,and
R3664 T4626 T4623 arg2Of positive,were
R3665 T4626 T4625 arg1Of positive,doubly
R3666 T4626 T4627 arg1Of positive,for
R3667 T4628 T4627 arg2Of κ,for
R3668 T4629 T4618 arg2Of and,determined
R3669 T4629 T4619 arg1Of and,that
R3670 T4630 T4629 arg2Of λ,and
R3671 T4632 T4630 arg2Of chains,λ
R3672 T4632 T4631 arg1Of chains,light
R3673 T4632 T4633 arg1Of chains,[
R3674 T4634 T4633 arg2Of 31,[
R3675 T4635 T4633 arg3Of ],[
R3676 T4637 T4636 arg1Of findings,These
R3677 T4637 T4638 arg1Of findings,indicate
R3678 T4640 T4641 arg1Of expression,of
R3679 T4640 T4643 arg1Of expression,in
R3680 T4640 T4646 arg1Of expression,promotes
R3681 T4640 T4652 arg1Of expression,can
R3682 T4640 T4653 arg1Of expression,result
R3683 T4642 T4641 arg2Of LMP1,of
R3684 T4645 T4643 arg2Of cells,in
R3685 T4645 T4644 arg1Of cells,B-1a
R3686 T4646 T4651 arg1Of promotes,and
R3687 T4648 T4646 arg2Of development,promotes
R3688 T4648 T4647 arg1Of development,the
R3689 T4648 T4649 arg1Of development,of
R3690 T4650 T4649 arg2Of malignancy,of
R3691 T4651 T4638 arg2Of and,indicate
R3692 T4651 T4639 arg1Of and,that
R3693 T4653 T4651 arg2Of result,and
R3694 T4653 T4652 arg2Of result,can
R3695 T4653 T4654 arg1Of result,in
R3696 T4657 T4654 arg2Of escape,in
R3697 T4657 T4655 arg1Of escape,the
R3698 T4657 T4656 arg1Of escape,aberrant
R3699 T4657 T4658 arg1Of escape,from
R3700 T4660 T4658 arg2Of exclusion,from
R3701 T4660 T4659 arg1Of exclusion,allelic
R4323 T5547 T5548 arg1Of LMP1,Promotes
R4324 T5551 T5552 arg1Of Survival,and
R4325 T5552 T5548 arg2Of and,Promotes
R4326 T5552 T5549 arg1Of and,B
R4327 T5552 T5550 arg1Of and,Cell
R4328 T5552 T5554 arg1Of and,In
R4329 T5553 T5552 arg2Of Proliferation,and
R4330 T5555 T5554 arg2Of Vitro,In
R4331 T5559 T5556 arg1Of cultures,Primary
R4332 T5559 T5557 arg1Of cultures,B
R4333 T5559 T5558 arg1Of cultures,cell
R4334 T5559 T5560 arg1Of cultures,can
R4335 T5559 T5561 arg1Of cultures,be
R4336 T5559 T5562 arg2Of cultures,maintained
R4337 T5562 T5560 arg2Of maintained,can
R4338 T5562 T5561 arg2Of maintained,be
R4339 T5562 T5563 arg1Of maintained,through
R4340 T5562 T5570 arg1Of maintained,[
R4341 T5565 T5566 arg1Of ligation,and
R4342 T5566 T5563 arg2Of and,through
R4343 T5566 T5564 arg1Of and,CD40
R4344 T5566 T5568 arg1Of and,with
R4345 T5567 T5566 arg2Of supplementation,and
R4346 T5569 T5568 arg2Of IL4,with
R4347 T5571 T5570 arg2Of 32,[
R4348 T5572 T5570 arg3Of ],[
R4349 T5574 T5573 arg1Of investigate,To
R4350 T5576 T5577 arg1Of LMP1,affects
R4351 T5577 T5574 arg2Of affects,investigate
R4352 T5577 T5575 arg1Of affects,whether
R4353 T5581 T5582 arg1Of survival,and
R4354 T5582 T5577 arg2Of and,affects
R4355 T5582 T5578 arg1Of and,primary
R4356 T5582 T5579 arg1Of and,B
R4357 T5582 T5580 arg1Of and,cell
R4358 T5583 T5582 arg2Of proliferation,and
R4359 T5585 T5574 arg1Of splenocytes,investigate
R4360 T5585 T5586 arg1Of splenocytes,were
R4361 T5585 T5587 arg2Of splenocytes,cultured
R4362 T5585 T5596 arg2Of splenocytes,analyzed
R4363 T5587 T5588 arg1Of cultured,in
R4364 T5587 T5595 arg1Of cultured,and
R4365 T5590 T5591 arg1Of presence,or
R4366 T5591 T5588 arg2Of or,in
R4367 T5591 T5589 arg1Of or,the
R4368 T5591 T5593 arg1Of or,of
R4369 T5592 T5591 arg2Of absence,or
R4370 T5594 T5593 arg2Of IL4,of
R4371 T5595 T5573 modOf and,To
R4372 T5595 T5584 arg1Of and,","
R4373 T5595 T5586 arg2Of and,were
R4374 T5596 T5595 arg2Of analyzed,and
R4375 T5596 T5597 arg1Of analyzed,by
R4376 T5596 T5599 arg1Of analyzed,as
R4377 T5596 T5603 arg1Of analyzed,","
R4378 T5596 T5611 arg1Of analyzed,for
R4379 T5596 T5615 arg1Of analyzed,by
R4380 T5598 T5597 arg2Of MTS,by
R4381 T5602 T5599 arg2Of marker,as
R4382 T5602 T5600 arg1Of marker,a
R4383 T5602 T5601 arg1Of marker,metabolic
R4384 T5606 T5605 arg1Of monoazide,ethidium
R4385 T5606 T5607 arg1Of monoazide,(
R4386 T5608 T5607 arg2Of EMA,(
R4387 T5609 T5607 arg3Of ),(
R4388 T5610 T5596 arg1Of exclusion,analyzed
R4389 T5610 T5604 arg2Of exclusion,by
R4390 T5610 T5606 arg1Of exclusion,monoazide
R4391 T5611 T5614 arg1Of for,and
R4392 T5612 T5611 arg2Of viability,for
R4393 T5614 T5613 arg1Of and,","
R4394 T5615 T5614 arg2Of by,and
R4395 T5618 T5617 arg2Of BrdU,(
R4396 T5619 T5617 arg3Of ),(
R4397 T5620 T5615 arg2Of incorporation,by
R4398 T5620 T5616 arg1Of incorporation,5-bromo-2′-deoxy-uridine
R4399 T5620 T5617 arg1Of incorporation,(
R4400 T5620 T5621 arg1Of incorporation,for
R4401 T5622 T5621 arg2Of proliferation,for
R4402 T5626 T5623 arg2Of assay,In
R4403 T5626 T5624 arg1Of assay,the
R4404 T5626 T5625 arg1Of assay,MTS
R4405 T5629 T5628 arg2Of expected,as
R4406 T5631 T5632 arg1Of splenocytes,from
R4407 T5631 T5635 arg1Of splenocytes,did
R4408 T5631 T5637 arg1Of splenocytes,survive
R4409 T5634 T5632 arg2Of mice,from
R4410 T5634 T5633 arg1Of mice,wild-type
R4411 T5637 T5623 arg1Of survive,In
R4412 T5637 T5627 arg1Of survive,","
R4413 T5637 T5628 arg1Of survive,as
R4414 T5637 T5630 arg1Of survive,","
R4415 T5637 T5635 arg2Of survive,did
R4416 T5637 T5636 arg1Of survive,not
R4417 T5637 T5639 arg1Of survive,with
R4418 T5639 T5638 arg1Of with,even
R4419 T5641 T5639 arg2Of addition,with
R4420 T5641 T5640 arg1Of addition,the
R4421 T5641 T5642 arg1Of addition,of
R4422 T5641 T5645 arg1Of addition,to
R4423 T5643 T5642 arg2Of IL4,of
R4424 T5645 T5644 arg1Of to,due
R4425 T5647 T5645 arg2Of lack,to
R4426 T5647 T5646 arg1Of lack,a
R4427 T5647 T5648 arg1Of lack,of
R4428 T5650 T5648 arg2Of ligation,of
R4429 T5650 T5649 arg1Of ligation,CD40
R4430 T5650 T5651 arg1Of ligation,(
R4431 T5653 T5651 arg2Of 3A,(
R4432 T5653 T5652 arg1Of 3A,Figure
R4433 T5654 T5651 arg3Of ),(
R4434 T5656 T5655 arg2Of contrast,In
R4435 T5659 T5658 arg1Of splenocytes,LMP1
R4436 T5659 T5660 arg1Of splenocytes,had
R4437 T5659 T5661 arg1Of splenocytes,increased
R4438 T5661 T5655 arg1Of increased,In
R4439 T5661 T5657 arg1Of increased,","
R4440 T5661 T5660 arg2Of increased,had
R4441 T5661 T5664 arg1Of increased,in
R4442 T5662 T5661 arg2Of metabolism,increased
R4443 T5664 T5663 arg1Of in,even
R4444 T5666 T5664 arg2Of absence,in
R4445 T5666 T5665 arg1Of absence,the
R4446 T5666 T5667 arg1Of absence,of
R4447 T5666 T5669 arg1Of absence,","
R4448 T5666 T5670 arg1Of absence,which
R4449 T5666 T5671 arg1Of absence,was
R4450 T5666 T5673 arg2Of absence,enhanced
R4451 T5668 T5667 arg2Of IL4,of
R4452 T5673 T5671 arg2Of enhanced,was
R4453 T5673 T5672 arg1Of enhanced,further
R4454 T5673 T5674 arg1Of enhanced,upon
R4455 T5675 T5674 arg2Of addition,upon
R4456 T5675 T5676 arg1Of addition,of
R4457 T5677 T5676 arg2Of IL4,of
R4458 T5678 T5679 arg1Of Wild-type,and
R4459 T5679 T5684 arg1Of and,had
R4460 T5683 T5679 arg2Of cells,and
R4461 T5683 T5680 arg1Of cells,LMP1
R4462 T5683 T5681 arg1Of cells,transgenic
R4463 T5683 T5682 arg1Of cells,lymphoma
R4464 T5684 T5691 arg1Of had,in
R4465 T5686 T5684 arg2Of levels,had
R4466 T5686 T5685 arg1Of levels,high
R4467 T5686 T5687 arg1Of levels,of
R4468 T5689 T5687 arg2Of activity,of
R4469 T5689 T5688 arg1Of activity,MTS
R4470 T5691 T5690 arg1Of in,even
R4471 T5693 T5691 arg2Of absence,in
R4472 T5693 T5692 arg1Of absence,the
R4473 T5693 T5694 arg1Of absence,of
R4474 T5695 T5694 arg2Of IL4,of
R4475 T5695 T5696 arg1Of IL4,(
R4476 T5698 T5696 arg2Of 3A,(
R4477 T5698 T5697 arg1Of 3A,Figure
R4478 T5699 T5696 arg3Of ),(
R4479 T5704 T5700 arg1Of cells,The
R4480 T5704 T5701 arg1Of cells,LMP1
R4481 T5704 T5702 arg1Of cells,transgenic
R4482 T5704 T5703 arg1Of cells,lymphoma
R4483 T5704 T5705 arg1Of cells,had
R4484 T5704 T5717 arg1Of cells,were
R4485 T5704 T5721 arg1Of cells,higher
R4486 T5705 T5716 arg1Of had,and
R4487 T5707 T5706 arg1Of 4-fold,approximately
R4488 T5708 T5707 arg1Of higher,4-fold
R4489 T5710 T5705 arg2Of activity,had
R4490 T5710 T5708 arg1Of activity,higher
R4491 T5710 T5709 arg1Of activity,MTS
R4492 T5710 T5711 arg1Of activity,than
R4493 T5715 T5711 arg2Of lymphocytes,than
R4494 T5715 T5712 arg1Of lymphocytes,the
R4495 T5715 T5713 arg1Of lymphocytes,normal
R4496 T5715 T5714 arg1Of lymphocytes,transgenic
R4497 T5717 T5716 arg2Of were,and
R4498 T5717 T5719 arg1Of were,least
R4499 T5719 T5718 arg1Of least,at
R4500 T5721 T5717 arg2Of higher,were
R4501 T5721 T5720 arg1Of higher,2-fold
R4502 T5721 T5722 arg1Of higher,than
R4503 T5725 T5722 arg2Of lymphoma,than
R4504 T5725 T5723 arg1Of lymphoma,the
R4505 T5725 T5724 arg1Of lymphoma,control
R4506 T5728 T5727 arg1Of published,previously
R4507 T5730 T5728 arg1Of lymphoma,published
R4508 T5730 T5729 arg1Of lymphoma,","
R4509 T5730 T5732 arg1Of lymphoma,develops
R4510 T5732 T5726 arg1Of develops,As
R4511 T5732 T5731 arg1Of develops,usually
R4512 T5732 T5733 arg1Of develops,in
R4513 T5732 T5735 arg1Of develops,over
R4514 T5732 T5740 arg1Of develops,and
R4515 T5734 T5733 arg2Of mice,in
R4516 T5737 T5735 arg2Of mo,over
R4517 T5737 T5736 arg1Of mo,12
R4518 T5737 T5738 arg1Of mo,of
R4519 T5739 T5738 arg2Of age,of
R4520 T5742 T5741 arg1Of mice,all
R4521 T5742 T5743 arg1Of mice,are
R4522 T5742 T5744 arg2Of mice,sacrificed
R4523 T5744 T5740 arg2Of sacrificed,and
R4524 T5744 T5743 arg2Of sacrificed,are
R4525 T5744 T5745 arg1Of sacrificed,by
R4526 T5747 T5745 arg2Of mo,by
R4527 T5747 T5746 arg1Of mo,18–20
R4528 T5749 T5748 arg1Of ages,The
R4529 T5749 T5750 arg1Of ages,of
R4530 T5749 T5758 arg1Of ages,ranged
R4531 T5753 T5750 arg2Of mice,of
R4532 T5753 T5751 arg1Of mice,the
R4533 T5753 T5752 arg1Of mice,transgenic
R4534 T5753 T5754 arg1Of mice,with
R4535 T5753 T5756 arg1Of mice,without
R4536 T5754 T5755 arg1Of with,or
R4537 T5756 T5755 arg2Of without,or
R4538 T5757 T5754 arg2Of lymphoma,with
R4539 T5757 T5756 arg2Of lymphoma,without
R4540 T5758 T5764 arg1Of ranged,old
R4541 T5760 T5761 arg1Of 6,and
R4542 T5761 T5759 arg1Of and,between
R4543 T5762 T5761 arg2Of 20,and
R4544 T5763 T5760 arg1Of mo,6
R4545 T5763 T5762 arg1Of mo,20
R4546 T5764 T5763 arg1Of old,mo
R4547 T5765 T5766 arg1Of There,was
R4548 T5768 T5766 arg2Of correlation,was
R4549 T5768 T5767 arg1Of correlation,no
R4550 T5768 T5769 arg1Of correlation,between
R4551 T5770 T5771 arg1Of age,and
R4552 T5771 T5769 arg2Of and,between
R4553 T5773 T5771 arg2Of activity,and
R4554 T5773 T5772 arg1Of activity,MTS
R4555 T5775 T5774 arg1Of exclusion,EMA
R4556 T5775 T5776 arg1Of exclusion,of
R4557 T5775 T5790 arg1Of exclusion,indicated
R4558 T5780 T5776 arg2Of cells,of
R4559 T5780 T5777 arg1Of cells,CD19+
R4560 T5780 T5778 arg2Of cells,gated
R4561 T5780 T5779 arg1Of cells,B
R4562 T5780 T5781 arg2Of cells,prepared
R4563 T5781 T5782 arg1Of prepared,from
R4564 T5784 T5785 arg1Of wild-type,and
R4565 T5786 T5785 arg2Of two,and
R4566 T5789 T5782 arg2Of mice,from
R4567 T5789 T5783 arg1Of mice,two
R4568 T5789 T5784 arg1Of mice,wild-type
R4569 T5789 T5786 arg1Of mice,two
R4570 T5789 T5787 arg1Of mice,LMP1
R4571 T5789 T5788 arg1Of mice,transgenic
R4572 T5793 T5790 arg2Of increase,indicated
R4573 T5793 T5791 arg1Of increase,a
R4574 T5793 T5792 arg1Of increase,2-fold
R4575 T5793 T5794 arg1Of increase,in
R4576 T5793 T5796 arg1Of increase,in
R4577 T5795 T5794 arg2Of viability,in
R4578 T5800 T5796 arg2Of lymphocytes,in
R4579 T5800 T5797 arg1Of lymphocytes,the
R4580 T5800 T5798 arg1Of lymphocytes,LMP1
R4581 T5800 T5799 arg1Of lymphocytes,transgenic
R4582 T5800 T5801 arg1Of lymphocytes,compared
R4583 T5802 T5801 arg2Of to,compared
R4584 T5804 T5802 arg2Of lymphocytes,to
R4585 T5804 T5803 arg1Of lymphocytes,wild-type
R4586 T5806 T5805 arg1Of examples,Two
R4587 T5806 T5807 arg1Of examples,of
R4588 T5806 T5812 arg1Of examples,had
R4589 T5811 T5807 arg2Of cells,of
R4590 T5811 T5808 arg1Of cells,LMP1
R4591 T5811 T5809 arg1Of cells,transgenic
R4592 T5811 T5810 arg1Of cells,lymphoma
R4593 T5814 T5813 arg1Of increased,greatly
R4594 T5815 T5812 arg2Of viability,had
R4595 T5815 T5814 arg1Of viability,increased
R4596 T5815 T5816 arg1Of viability,that
R4597 T5815 T5817 arg1Of viability,was
R4598 T5815 T5819 arg2Of viability,increased
R4599 T5819 T5817 arg2Of increased,was
R4600 T5819 T5818 arg1Of increased,not
R4601 T5819 T5823 arg1Of increased,","
R4602 T5819 T5824 modOf increased,indicating
R4603 T5822 T5819 arg1Of treatment,increased
R4604 T5822 T5820 arg2Of treatment,by
R4605 T5822 T5821 arg1Of treatment,IL4
R4606 T5828 T5826 arg1Of cells,the
R4607 T5828 T5827 arg1Of cells,lymphoma
R4608 T5828 T5829 arg1Of cells,are
R4609 T5828 T5830 arg1Of cells,independent
R4610 T5829 T5824 arg2Of are,indicating
R4611 T5829 T5825 arg1Of are,that
R4612 T5830 T5829 arg2Of independent,are
R4613 T5830 T5831 arg1Of independent,of
R4614 T5833 T5831 arg2Of co-stimulation,of
R4615 T5833 T5832 arg1Of co-stimulation,IL4
R4616 T5833 T5834 arg1Of co-stimulation,(
R4617 T5836 T5834 arg2Of 3B,(
R4618 T5836 T5835 arg1Of 3B,Figure
R4619 T5837 T5834 arg3Of ),(
R4620 T5838 T5839 arg1Of Enhancement,in
R4621 T5838 T5842 arg1Of Enhancement,was
R4622 T5838 T5843 arg2Of Enhancement,observed
R4623 T5841 T5839 arg2Of activity,in
R4624 T5841 T5840 arg1Of activity,MTS
R4625 T5843 T5842 arg2Of observed,was
R4626 T5843 T5844 arg1Of observed,in
R4627 T5843 T5849 arg1Of observed,by
R4628 T5843 T5854 arg1Of observed,;
R4629 T5848 T5844 arg2Of cells,in
R4630 T5848 T5845 arg1Of cells,LMP1
R4631 T5848 T5846 arg1Of cells,transgenic
R4632 T5848 T5847 arg1Of cells,lymphoma
R4633 T5851 T5849 arg2Of addition,by
R4634 T5851 T5850 arg1Of addition,the
R4635 T5851 T5852 arg1Of addition,of
R4636 T5853 T5852 arg2Of IL4,of
R4637 T5858 T5857 arg1Of exclusion,EMA
R4638 T5858 T5859 arg1Of exclusion,did
R4639 T5858 T5861 arg1Of exclusion,reveal
R4640 T5861 T5854 arg2Of reveal,;
R4641 T5861 T5855 arg1Of reveal,however
R4642 T5861 T5856 arg1Of reveal,","
R4643 T5861 T5859 arg2Of reveal,did
R4644 T5861 T5860 arg1Of reveal,not
R4645 T5864 T5861 arg2Of increase,reveal
R4646 T5864 T5862 arg1Of increase,a
R4647 T5864 T5863 arg1Of increase,similar
R4648 T5865 T5866 arg1Of This,could
R4649 T5865 T5867 arg1Of This,reflect
R4650 T5867 T5866 arg2Of reflect,could
R4651 T5869 T5867 arg2Of difference,reflect
R4652 T5869 T5868 arg1Of difference,a
R4653 T5869 T5870 arg1Of difference,for
R4654 T5872 T5870 arg2Of requirement,for
R4655 T5872 T5871 arg1Of requirement,IL4
R4656 T5872 T5873 arg1Of requirement,in
R4657 T5876 T5873 arg2Of activity,in
R4658 T5876 T5874 arg1Of activity,the
R4659 T5876 T5875 arg1Of activity,metabolic
R4660 T5876 T5877 arg1Of activity,versus
R4661 T5879 T5877 arg2Of viability,versus
R4662 T5879 T5878 arg1Of viability,the
R4663 T5879 T5880 arg1Of viability,of
R4664 T5884 T5880 arg2Of cells,of
R4665 T5884 T5881 arg1Of cells,LMP1
R4666 T5884 T5882 arg1Of cells,transgenic
R4667 T5884 T5883 arg1Of cells,lymphoma
R4668 T5886 T5887 arg1Of expression,of
R4669 T5886 T5889 arg1Of expression,could
R4670 T5886 T5890 arg1Of expression,enhance
R4671 T5888 T5887 arg2Of LMP1,of
R4672 T5890 T5885 arg2Of enhance,Although
R4673 T5890 T5889 arg2Of enhance,could
R4674 T5891 T5890 arg2Of survival,enhance
R4675 T5891 T5892 arg1Of survival,of
R4676 T5895 T5892 arg2Of lymphocytes,of
R4677 T5895 T5893 arg1Of lymphocytes,non-malignant
R4678 T5895 T5894 arg1Of lymphocytes,primary
R4679 T5898 T5897 arg1Of incorporation,BrdU
R4680 T5898 T5899 arg1Of incorporation,revealed
R4681 T5899 T5885 arg1Of revealed,Although
R4682 T5899 T5896 arg1Of revealed,","
R4683 T5902 T5901 arg1Of expression,LMP1
R4684 T5902 T5903 arg1Of expression,alone
R4685 T5902 T5904 arg1Of expression,was
R4686 T5902 T5906 arg1Of expression,sufficient
R4687 T5904 T5899 arg2Of was,revealed
R4688 T5904 T5900 arg1Of was,that
R4689 T5904 T5905 arg1Of was,not
R4690 T5904 T5907 modOf was,to
R4691 T5906 T5904 arg2Of sufficient,was
R4692 T5908 T5907 arg1Of induce,to
R4693 T5908 T5910 arg1Of induce,in
R4694 T5909 T5908 arg2Of proliferation,induce
R4695 T5911 T5910 arg2Of culture,in
R4696 T5911 T5912 arg1Of culture,(
R4697 T5914 T5912 arg2Of data,(
R4698 T5914 T5913 arg1Of data,unpublished
R4699 T5915 T5912 arg3Of ),(
R4700 T5918 T5916 arg1Of cells,Only
R4701 T5918 T5917 arg1Of cells,lymphoma
R4702 T5918 T5919 arg1Of cells,had
R4703 T5921 T5919 arg2Of levels,had
R4704 T5921 T5920 arg1Of levels,detectable
R4705 T5921 T5922 arg1Of levels,of
R4706 T5924 T5922 arg2Of incorporation,of
R4707 T5924 T5923 arg1Of incorporation,BrdU
R4708 T5924 T5925 arg2Of incorporation,detected
R4709 T5928 T5925 arg1Of cytometry,detected
R4710 T5928 T5926 arg2Of cytometry,by
R4711 T5928 T5927 arg1Of cytometry,flow
R4712 T5928 T5929 arg1Of cytometry,(
R4713 T5931 T5929 arg2Of 3C,(
R4714 T5931 T5930 arg1Of 3C,Figure
R4715 T5932 T5929 arg3Of ),(
R4716 T5937 T5935 arg1Of cells,LMP1
R4717 T5937 T5936 arg1Of cells,lymphoma
R4718 T5937 T5938 arg1Of cells,had
R4719 T5938 T5933 arg1Of had,Interestingly
R4720 T5938 T5934 arg1Of had,","
R4721 T5938 T5944 arg1Of had,in
R4722 T5940 T5939 arg1Of higher,significantly
R4723 T5941 T5938 arg2Of levels,had
R4724 T5941 T5940 arg1Of levels,higher
R4725 T5941 T5942 arg1Of levels,of
R4726 T5943 T5942 arg2Of proliferation,of
R4727 T5944 T5946 arg1Of in,to
R4728 T5945 T5944 arg2Of comparison,in
R4729 T5949 T5944 arg3Of lymphoma,in
R4730 T5949 T5947 arg1Of lymphoma,the
R4731 T5949 T5948 arg1Of lymphoma,spontaneous
R4732 T5949 T5950 arg1Of lymphoma,that
R4733 T5949 T5951 arg1Of lymphoma,developed
R4734 T5951 T5952 arg1Of developed,in
R4735 T5955 T5952 arg2Of littermate,in
R4736 T5955 T5953 arg1Of littermate,an
R4737 T5955 T5954 arg1Of littermate,LMP1-negative
R4738 T5955 T5956 arg1Of littermate,(
R4739 T5958 T5957 arg1Of %,25
R4740 T5961 T5956 arg2Of %,(
R4741 T5961 T5958 arg1Of %,%
R4742 T5961 T5959 arg1Of %,versus
R4743 T5961 T5960 arg1Of %,4
R4744 T5962 T5956 arg3Of ),(
R4745 T5965 T5963 arg1Of level,This
R4746 T5965 T5964 arg1Of level,higher
R4747 T5965 T5966 arg1Of level,of
R4748 T5965 T5968 arg1Of level,was
R4749 T5965 T5969 arg2Of level,observed
R4750 T5967 T5966 arg2Of proliferation,of
R4751 T5969 T5968 arg2Of observed,was
R4752 T5969 T5970 arg1Of observed,in
R4753 T5969 T5995 arg1Of observed,","
R4754 T5969 T5996 modOf observed,suggesting
R4755 T5971 T5970 arg2Of lymphomas,in
R4756 T5971 T5972 arg1Of lymphomas,that
R4757 T5971 T5973 arg1Of lymphomas,express
R4758 T5978 T5975 arg1Of 1,high
R4759 T5978 T5976 arg2Of 1,(
R4760 T5978 T5977 arg1Of 1,Table
R4761 T5978 T5979 arg1Of 1,","
R4762 T5978 T5984 arg1Of 1,and
R4763 T5980 T5981 arg1Of LMP1-L2,and
R4764 T5981 T5979 arg2Of and,","
R4765 T5982 T5981 arg2Of LMP1-L3,and
R4766 T5983 T5976 arg3Of ),(
R4767 T5984 T5973 arg2Of and,express
R4768 T5984 T5974 arg1Of and,both
R4769 T5985 T5986 arg1Of low,(
R4770 T5988 T5986 arg2Of 1,(
R4771 T5988 T5987 arg1Of 1,Table
R4772 T5988 T5989 arg1Of 1,","
R4773 T5990 T5989 arg2Of LMP1-L5,","
R4774 T5991 T5986 arg3Of ),(
R4775 T5992 T5984 arg2Of levels,and
R4776 T5992 T5985 arg1Of levels,low
R4777 T5992 T5993 arg1Of levels,of
R4778 T5994 T5993 arg2Of LMP1,of
R4779 T6000 T5998 arg1Of amounts,even
R4780 T6000 T5999 arg1Of amounts,small
R4781 T6000 T6001 arg1Of amounts,of
R4782 T6000 T6003 arg1Of amounts,is
R4783 T6000 T6004 arg1Of amounts,sufficient
R4784 T6002 T6001 arg2Of LMP1,of
R4785 T6003 T5996 arg2Of is,suggesting
R4786 T6003 T5997 arg1Of is,that
R4787 T6004 T6003 arg2Of sufficient,is
R4788 T6006 T6004 arg2Of induce,sufficient
R4789 T6006 T6005 arg1Of induce,to
R4790 T6006 T6009 arg1Of induce,in
R4791 T6008 T6006 arg2Of effects,induce
R4792 T6008 T6007 arg1Of effects,dramatic
R4793 T6010 T6009 arg2Of proliferation,in
R4794 T6012 T6011 arg1Of level,The
R4795 T6012 T6013 arg1Of level,of
R4796 T6012 T6015 arg1Of level,was
R4797 T6012 T6017 arg2Of level,enhanced
R4798 T6014 T6013 arg2Of proliferation,of
R4799 T6017 T6015 arg2Of enhanced,was
R4800 T6017 T6016 arg1Of enhanced,not
R4801 T6017 T6018 arg1Of enhanced,upon
R4802 T6017 T6021 arg1Of enhanced,","
R4803 T6020 T6018 arg2Of addition,upon
R4804 T6020 T6019 arg1Of addition,IL4
R4805 T6022 T6017 arg3Of confirming,enhanced
R4806 T6025 T6022 arg2Of independence,confirming
R4807 T6025 T6023 arg1Of independence,the
R4808 T6025 T6024 arg1Of independence,IL4
R4809 T6025 T6026 arg2Of independence,observed
R4810 T6026 T6027 arg1Of observed,in
R4811 T6030 T6027 arg2Of studies,in
R4812 T6030 T6028 arg1Of studies,the
R4813 T6030 T6029 arg1Of studies,viability
R4814 T6030 T6031 arg1Of studies,(
R4815 T6033 T6031 arg2Of 3C,(
R4816 T6033 T6032 arg1Of 3C,Figure
R4817 T6033 T6034 arg1Of 3C,;
R4818 T6035 T6034 arg2Of Table1,;
R4819 T6036 T6031 arg3Of ),(
R4898 T6408 T6409 arg1Of wild-type,and
R4899 T6409 T6416 arg1Of and,Require
R4900 T6414 T6409 arg2Of Do,and
R4901 T6414 T6410 arg1Of Do,LMP1
R4902 T6414 T6411 arg1Of Do,transgenic
R4903 T6414 T6412 arg1Of Do,lymphoma
R4904 T6414 T6413 arg1Of Do,Cells
R4905 T6416 T6415 arg1Of Require,Not
R4906 T6417 T6418 arg1Of IL4,and
R4907 T6419 T6418 arg2Of Stat6,and
R4908 T6420 T6416 arg2Of Signaling,Require
R4909 T6420 T6417 arg1Of Signaling,IL4
R4910 T6420 T6419 arg1Of Signaling,Stat6
R4911 T6422 T6421 arg1Of investigate,To
R4912 T6425 T6424 arg1Of independence,IL4
R4913 T6425 T6426 arg1Of independence,was
R4914 T6425 T6427 arg1Of independence,due
R4915 T6426 T6422 arg2Of was,investigate
R4916 T6426 T6423 arg1Of was,whether
R4917 T6427 T6426 arg2Of due,was
R4918 T6427 T6428 arg1Of due,to
R4919 T6431 T6428 arg2Of expression,to
R4920 T6431 T6429 arg1Of expression,endogenous
R4921 T6431 T6430 arg1Of expression,IL4
R4922 T6434 T6422 arg1Of transcription,investigate
R4923 T6434 T6433 arg1Of transcription,IL4
R4924 T6434 T6435 arg1Of transcription,was
R4925 T6434 T6436 arg2Of transcription,assessed
R4926 T6436 T6421 modOf assessed,To
R4927 T6436 T6432 arg1Of assessed,","
R4928 T6436 T6435 arg2Of assessed,was
R4929 T6441 T6436 arg1Of assay,assessed
R4930 T6441 T6437 arg2Of assay,by
R4931 T6441 T6438 arg1Of assay,an
R4932 T6441 T6439 arg1Of assay,Rnase
R4933 T6441 T6440 arg1Of assay,protection
R4934 T6441 T6442 arg1Of assay,(
R4935 T6443 T6442 arg2Of RPA,(
R4936 T6444 T6442 arg3Of ),(
R4937 T6446 T6445 arg1Of transcription,IL4
R4938 T6446 T6447 arg1Of transcription,was
R4939 T6446 T6448 arg1Of transcription,detectable
R4940 T6448 T6447 arg2Of detectable,was
R4941 T6448 T6449 arg1Of detectable,with
R4942 T6448 T6454 arg1Of detectable,in
R4943 T6449 T6452 arg1Of with,and
R4944 T6451 T6449 arg2Of RNA,with
R4945 T6451 T6450 arg1Of RNA,control
R4946 T6454 T6452 arg2Of in,and
R4947 T6454 T6453 arg1Of in,faintly
R4948 T6460 T6454 arg2Of K46μ,in
R4949 T6460 T6455 arg1Of K46μ,the
R4950 T6460 T6456 arg1Of K46μ,mouse
R4951 T6460 T6457 arg1Of K46μ,lymphoma
R4952 T6460 T6458 arg1Of K46μ,cell
R4953 T6460 T6459 arg1Of K46μ,line
R4954 T6460 T6461 arg1Of K46μ,(
R4955 T6463 T6461 arg2Of 4A,(
R4956 T6463 T6462 arg1Of 4A,Figure
R4957 T6464 T6461 arg3Of ),(
R4958 T6468 T6467 arg1Of transcription,IL4
R4959 T6468 T6469 arg1Of transcription,was
R4960 T6468 T6471 arg1Of transcription,detectable
R4961 T6469 T6465 arg1Of was,However
R4962 T6469 T6466 arg1Of was,","
R4963 T6469 T6470 arg1Of was,not
R4964 T6469 T6492 arg1Of was,","
R4965 T6469 T6493 arg1Of was,although
R4966 T6471 T6469 arg2Of detectable,was
R4967 T6471 T6472 arg1Of detectable,in
R4968 T6476 T6473 arg1Of cells,CD19+
R4969 T6476 T6474 arg1Of cells,MACS-purified
R4970 T6476 T6475 arg1Of cells,B
R4971 T6476 T6477 arg1Of cells,from
R4972 T6476 T6484 arg1Of cells,","
R4973 T6479 T6477 arg2Of lymphocytes,from
R4974 T6479 T6478 arg1Of lymphocytes,wild-type
R4975 T6479 T6480 arg1Of lymphocytes,(
R4976 T6482 T6480 arg2Of data,(
R4977 T6482 T6481 arg1Of data,unpublished
R4978 T6483 T6480 arg3Of ),(
R4979 T6484 T6489 arg1Of ",",or
R4980 T6487 T6484 arg2Of lymphocytes,","
R4981 T6487 T6485 arg1Of lymphocytes,LMP1
R4982 T6487 T6486 arg1Of lymphocytes,transgenic
R4983 T6489 T6472 arg2Of or,in
R4984 T6489 T6488 arg1Of or,","
R4985 T6491 T6489 arg2Of cells,or
R4986 T6491 T6490 arg1Of cells,lymphoma
R4987 T6495 T6496 arg1Of GAPDH,and
R4988 T6497 T6496 arg2Of L32,and
R4989 T6498 T6494 arg1Of controls,the
R4990 T6498 T6495 arg1Of controls,GAPDH
R4991 T6498 T6497 arg1Of controls,L32
R4992 T6498 T6499 arg1Of controls,were
R4993 T6498 T6501 arg2Of controls,protected
R4994 T6501 T6493 arg2Of protected,although
R4995 T6501 T6499 arg2Of protected,were
R4996 T6501 T6500 arg1Of protected,effectively
R4997 T6501 T6502 arg1Of protected,(
R4998 T6504 T6502 arg2Of 4A,(
R4999 T6504 T6503 arg1Of 4A,Figure
R5000 T6505 T6502 arg3Of ),(
R5001 T6507 T6506 arg2Of Stat6,Activated
R5002 T6507 T6508 arg1Of Stat6,(
R5003 T6507 T6511 arg1Of Stat6,","
R5004 T6507 T6520 arg1Of Stat6,was
R5005 T6507 T6521 arg2Of Stat6,detected
R5006 T6509 T6508 arg2Of pStat6,(
R5007 T6510 T6508 arg3Of ),(
R5008 T6513 T6511 arg2Of target,","
R5009 T6513 T6512 arg1Of target,a
R5010 T6513 T6514 arg1Of target,of
R5011 T6518 T6514 arg2Of pathway,of
R5012 T6518 T6515 arg1Of pathway,the
R5013 T6518 T6516 arg1Of pathway,IL4
R5014 T6518 T6517 arg1Of pathway,receptor
R5015 T6521 T6519 arg1Of detected,","
R5016 T6521 T6520 arg2Of detected,was
R5017 T6521 T6522 arg1Of detected,in
R5018 T6524 T6525 arg1Of wild-type,and
R5019 T6525 T6522 arg2Of and,in
R5020 T6525 T6523 arg1Of and,the
R5021 T6528 T6525 arg2Of lymphocytes,and
R5022 T6528 T6526 arg1Of lymphocytes,LMP1
R5023 T6528 T6527 arg1Of lymphocytes,transgenic
R5024 T6528 T6529 arg1Of lymphocytes,(
R5025 T6531 T6529 arg2Of 4B,(
R5026 T6531 T6530 arg1Of 4B,Figure
R5027 T6532 T6529 arg3Of ),(
R5028 T6534 T6533 arg2Of contrast,In
R5029 T6536 T6537 arg1Of pStat6,was
R5030 T6536 T6539 arg2Of pStat6,detected
R5031 T6539 T6533 arg1Of detected,In
R5032 T6539 T6535 arg1Of detected,","
R5033 T6539 T6537 arg2Of detected,was
R5034 T6539 T6538 arg1Of detected,barely
R5035 T6539 T6540 arg1Of detected,in
R5036 T6543 T6544 arg1Of wild-type,or
R5037 T6545 T6544 arg2Of LMP1,or
R5038 T6548 T6540 arg2Of cells,in
R5039 T6548 T6541 arg1Of cells,either
R5040 T6548 T6542 arg1Of cells,the
R5041 T6548 T6543 arg1Of cells,wild-type
R5042 T6548 T6545 arg1Of cells,LMP1
R5043 T6548 T6546 arg1Of cells,transgenic
R5044 T6548 T6547 arg1Of cells,lymphoma
R5045 T6552 T6551 arg1Of pathway,the
R5046 T6552 T6553 arg1Of pathway,was
R5047 T6552 T6555 arg2Of pathway,disabled
R5048 T6555 T6549 arg1Of disabled,However
R5049 T6555 T6550 arg1Of disabled,","
R5050 T6555 T6553 arg2Of disabled,was
R5051 T6555 T6554 arg1Of disabled,not
R5052 T6555 T6556 arg1Of disabled,","
R5053 T6555 T6557 arg1Of disabled,as
R5054 T6558 T6559 arg1Of treatment,of
R5055 T6558 T6563 arg1Of treatment,with
R5056 T6558 T6565 arg1Of treatment,induced
R5057 T6562 T6559 arg2Of cells,of
R5058 T6562 T6560 arg1Of cells,the
R5059 T6562 T6561 arg1Of cells,lymphoma
R5060 T6564 T6563 arg2Of IL4,with
R5061 T6565 T6557 arg2Of induced,as
R5062 T6567 T6565 arg2Of phosphorylation,induced
R5063 T6567 T6566 arg1Of phosphorylation,Stat6
R5064 T6567 T6568 arg1Of phosphorylation,(
R5065 T6570 T6568 arg2Of 4C,(
R5066 T6570 T6569 arg1Of 4C,Figure
R5067 T6571 T6568 arg3Of ),(
R5068 T6574 T6573 arg1Of lymphocytes,wild-type
R5069 T6574 T6575 arg1Of lymphocytes,can
R5070 T6574 T6577 arg1Of lymphocytes,be
R5071 T6574 T6578 arg2Of lymphocytes,maintained
R5072 T6578 T6572 arg2Of maintained,Although
R5073 T6578 T6575 arg2Of maintained,can
R5074 T6578 T6576 arg1Of maintained,not
R5075 T6578 T6577 arg2Of maintained,be
R5076 T6578 T6579 arg1Of maintained,in
R5077 T6580 T6579 arg2Of culture,in
R5078 T6580 T6581 arg1Of culture,with
R5079 T6583 T6581 arg2Of supplementation,with
R5080 T6583 T6582 arg1Of supplementation,IL4
R5081 T6583 T6584 arg1Of supplementation,alone
R5082 T6583 T6585 arg1Of supplementation,(
R5083 T6587 T6585 arg2Of 3A,(
R5084 T6587 T6586 arg1Of 3A,Figure
R5085 T6588 T6585 arg3Of ),(
R5086 T6591 T6590 arg1Of enhancement,slight
R5087 T6591 T6592 arg1Of enhancement,in
R5088 T6591 T6595 arg1Of enhancement,could
R5089 T6591 T6596 arg1Of enhancement,be
R5090 T6591 T6597 arg2Of enhancement,detected
R5091 T6594 T6592 arg2Of activity,in
R5092 T6594 T6593 arg1Of activity,MTS
R5093 T6597 T6572 arg1Of detected,Although
R5094 T6597 T6589 arg1Of detected,","
R5095 T6597 T6595 arg2Of detected,could
R5096 T6597 T6596 arg2Of detected,be
R5097 T6597 T6598 arg1Of detected,if
R5098 T6597 T6608 arg1Of detected,","
R5099 T6597 T6609 arg1Of detected,at
R5100 T6600 T6599 arg1Of cells,the
R5101 T6600 T6601 arg1Of cells,were
R5102 T6600 T6602 arg2Of cells,analyzed
R5103 T6602 T6598 arg2Of analyzed,if
R5104 T6602 T6601 arg2Of analyzed,were
R5105 T6602 T6603 arg1Of analyzed,at
R5106 T6607 T6603 arg2Of point,at
R5107 T6607 T6604 arg1Of point,an
R5108 T6607 T6605 arg1Of point,earlier
R5109 T6607 T6606 arg1Of point,time
R5110 T6611 T6609 arg2Of d,at
R5111 T6611 T6610 arg1Of d,1
R5112 T6611 T6612 arg1Of d,(
R5113 T6611 T6616 arg1Of d,versus
R5114 T6611 T6623 arg1Of d,post-harvest
R5115 T6614 T6612 arg2Of 4D,(
R5116 T6614 T6613 arg1Of 4D,Figure
R5117 T6615 T6612 arg3Of ),(
R5118 T6618 T6616 arg2Of d,versus
R5119 T6618 T6617 arg1Of d,3
R5120 T6618 T6619 arg1Of d,(
R5121 T6621 T6619 arg2Of 3A,(
R5122 T6621 T6620 arg1Of 3A,Figure
R5123 T6622 T6619 arg3Of ),(
R5124 T6625 T6624 arg1Of enhancement,The
R5125 T6625 T6626 arg1Of enhancement,of
R5126 T6625 T6635 arg1Of enhancement,could
R5127 T6625 T6636 arg1Of enhancement,be
R5128 T6625 T6637 arg2Of enhancement,neutralized
R5129 T6628 T6626 arg2Of activity,of
R5130 T6628 T6627 arg1Of activity,MTS
R5131 T6628 T6629 arg2Of activity,induced
R5132 T6631 T6629 arg1Of IL4,induced
R5133 T6631 T6630 arg2Of IL4,by
R5134 T6631 T6632 arg1Of IL4,in
R5135 T6634 T6632 arg2Of lymphocytes,in
R5136 T6634 T6633 arg1Of lymphocytes,wild-type
R5137 T6637 T6635 arg2Of neutralized,could
R5138 T6637 T6636 arg2Of neutralized,be
R5139 T6640 T6637 arg1Of addition,neutralized
R5140 T6640 T6638 arg2Of addition,by
R5141 T6640 T6639 arg1Of addition,the
R5142 T6640 T6641 arg1Of addition,of
R5143 T6643 T6641 arg2Of antibody,of
R5144 T6643 T6642 arg1Of antibody,IL4
R5145 T6643 T6644 arg1Of antibody,(
R5146 T6646 T6644 arg2Of 4D,(
R5147 T6646 T6645 arg1Of 4D,Figure
R5148 T6647 T6644 arg3Of ),(
R5149 T6651 T6650 arg1Of antibodies,neutralizing
R5150 T6651 T6652 arg1Of antibodies,to
R5151 T6651 T6654 arg1Of antibodies,did
R5152 T6651 T6656 arg1Of antibodies,affect
R5153 T6653 T6652 arg2Of IL4,to
R5154 T6656 T6648 arg1Of affect,However
R5155 T6656 T6649 arg1Of affect,","
R5156 T6656 T6654 arg2Of affect,did
R5157 T6656 T6655 arg1Of affect,not
R5158 T6659 T6656 arg2Of activity,affect
R5159 T6659 T6657 arg1Of activity,the
R5160 T6659 T6658 arg1Of activity,MTS
R5161 T6659 T6660 arg1Of activity,of
R5162 T6664 T6660 arg2Of cells,of
R5163 T6664 T6661 arg1Of cells,LMP1
R5164 T6664 T6662 arg1Of cells,transgenic
R5165 T6664 T6663 arg1Of cells,lymphoma
R5166 T6664 T6665 arg1Of cells,(
R5167 T6667 T6665 arg2Of 4E,(
R5168 T6667 T6666 arg1Of 4E,Figure
R5169 T6668 T6665 arg3Of ),(
R5170 T6670 T6669 arg2Of summary,In
R5171 T6678 T6672 arg1Of cells,the
R5172 T6678 T6673 arg1Of cells,wild-type
R5173 T6678 T6674 arg1Of cells,and
R5174 T6678 T6675 arg1Of cells,LMP1
R5175 T6678 T6676 arg1Of cells,transgenic
R5176 T6678 T6677 arg1Of cells,lymphoma
R5177 T6678 T6679 arg1Of cells,grew
R5178 T6678 T6685 arg1Of cells,did
R5179 T6678 T6687 arg1Of cells,require
R5180 T6679 T6680 arg1Of grew,independently
R5181 T6679 T6681 arg1Of grew,of
R5182 T6679 T6684 arg1Of grew,and
R5183 T6683 T6681 arg2Of treatment,of
R5184 T6683 T6682 arg1Of treatment,IL4
R5185 T6684 T6669 arg1Of and,In
R5186 T6684 T6671 arg1Of and,","
R5187 T6687 T6684 arg2Of require,and
R5188 T6687 T6685 arg2Of require,did
R5189 T6687 T6686 arg1Of require,not
R5190 T6689 T6687 arg2Of signaling,require
R5191 T6689 T6688 arg1Of signaling,Stat6
R5724 T7580 T7581 arg1Of LMP1,Upregulates
R5725 T7580 T7585 arg1Of LMP1,Activates
R5726 T7581 T7583 arg1Of Upregulates,and
R5727 T7582 T7581 arg2Of IL10,Upregulates
R5728 T7585 T7583 arg2Of Activates,and
R5729 T7585 T7584 arg1Of Activates,Constitutively
R5730 T7586 T7585 arg2Of Stat3,Activates
R5731 T7588 T7587 arg1Of identify,To
R5732 T7589 T7588 arg2Of cytokines,identify
R5733 T7589 T7590 arg1Of cytokines,that
R5734 T7589 T7591 arg1Of cytokines,may
R5735 T7589 T7592 arg1Of cytokines,contribute
R5736 T7592 T7591 arg2Of contribute,may
R5737 T7592 T7593 arg1Of contribute,to
R5738 T7596 T7597 arg1Of survival,and
R5739 T7597 T7593 arg2Of and,to
R5740 T7597 T7594 arg1Of and,the
R5741 T7597 T7595 arg2Of and,increased
R5742 T7597 T7599 arg1Of and,of
R5743 T7598 T7597 arg2Of growth,and
R5744 T7600 T7599 arg2Of lymphomas,of
R5745 T7604 T7602 arg1Of levels,the
R5746 T7604 T7603 arg1Of levels,expression
R5747 T7604 T7605 arg1Of levels,of
R5748 T7604 T7610 arg1Of levels,were
R5749 T7604 T7611 arg2Of levels,screened
R5750 T7607 T7605 arg2Of panel,of
R5751 T7607 T7606 arg1Of panel,a
R5752 T7607 T7608 arg1Of panel,of
R5753 T7609 T7608 arg2Of cytokines,of
R5754 T7611 T7587 modOf screened,To
R5755 T7611 T7601 arg1Of screened,","
R5756 T7611 T7610 arg2Of screened,were
R5757 T7611 T7612 arg1Of screened,on
R5758 T7611 T7617 arg1Of screened,","
R5759 T7611 T7618 modOf screened,using
R5760 T7616 T7612 arg2Of cells,on
R5761 T7616 T7613 arg1Of cells,CD19+
R5762 T7616 T7614 arg1Of cells,MACS-purified
R5763 T7616 T7615 arg1Of cells,B
R5764 T7621 T7618 arg2Of probe,using
R5765 T7621 T7619 arg1Of probe,an
R5766 T7621 T7620 arg1Of probe,RPA
R5767 T7621 T7622 arg2Of probe,set
R5768 T7622 T7623 arg1Of set,for
R5769 T7624 T7625 arg1Of IL4,","
R5770 T7625 T7627 arg1Of ",",","
R5771 T7626 T7625 arg2Of IL5,","
R5772 T7627 T7629 arg1Of ",",","
R5773 T7628 T7627 arg2Of IL10,","
R5774 T7629 T7631 arg1Of ",",","
R5775 T7630 T7629 arg2Of IL13,","
R5776 T7631 T7633 arg1Of ",",","
R5777 T7632 T7631 arg2Of IL15,","
R5778 T7633 T7635 arg1Of ",",","
R5779 T7634 T7633 arg2Of IL9,","
R5780 T7635 T7623 arg2Of ",",for
R5781 T7636 T7637 arg1Of IL2,","
R5782 T7637 T7640 arg1Of ",",and
R5783 T7638 T7637 arg2Of IL6,","
R5784 T7640 T7635 arg2Of and,","
R5785 T7640 T7639 arg1Of and,","
R5786 T7641 T7640 arg2Of IFNγ,and
R5787 T7643 T7642 arg1Of levels,Expression
R5788 T7643 T7644 arg1Of levels,were
R5789 T7643 T7645 arg2Of levels,quantified
R5790 T7643 T7650 arg1Of levels,normalized
R5791 T7645 T7644 arg2Of quantified,were
R5792 T7645 T7646 arg1Of quantified,with
R5793 T7645 T7649 arg1Of quantified,and
R5794 T7648 T7646 arg2Of phosphorimager,with
R5795 T7648 T7647 arg1Of phosphorimager,a
R5796 T7650 T7649 arg2Of normalized,and
R5797 T7650 T7651 arg1Of normalized,to
R5798 T7656 T7651 arg2Of L32,to
R5799 T7656 T7652 arg1Of L32,the
R5800 T7656 T7653 arg1Of L32,ribosomal
R5801 T7656 T7654 arg1Of L32,housekeeping
R5802 T7656 T7655 arg1Of L32,gene
R5803 T7657 T7658 arg1Of None,of
R5804 T7657 T7662 arg1Of None,were
R5805 T7657 T7663 arg2Of None,detected
R5806 T7661 T7658 arg2Of cytokines,of
R5807 T7661 T7659 arg1Of cytokines,the
R5808 T7661 T7660 arg2Of cytokines,tested
R5809 T7663 T7662 arg2Of detected,were
R5810 T7663 T7664 arg1Of detected,in
R5811 T7663 T7667 arg1Of detected,","
R5812 T7666 T7664 arg2Of lymphocytes,in
R5813 T7666 T7665 arg1Of lymphocytes,wild-type
R5814 T7669 T7670 arg1Of cytokine,:
R5815 T7670 T7668 arg1Of :,therefore
R5816 T7670 T7673 arg1Of :,were
R5817 T7670 T7674 arg2Of :,set
R5818 T7672 T7670 arg2Of ratios,:
R5819 T7672 T7671 arg1Of ratios,L32
R5820 T7674 T7667 arg2Of set,","
R5821 T7674 T7673 arg2Of set,were
R5822 T7674 T7675 arg1Of set,to
R5823 T7674 T7677 arg1Of set,in
R5824 T7676 T7675 arg2Of 1,to
R5825 T7683 T7677 arg2Of line,in
R5826 T7683 T7678 arg1Of line,the
R5827 T7683 T7679 arg1Of line,mouse
R5828 T7683 T7680 arg1Of line,B
R5829 T7683 T7681 arg1Of line,cell
R5830 T7683 T7682 arg1Of line,lymphoma
R5831 T7683 T7684 arg1Of line,967
R5832 T7685 T7686 arg1Of Transcription,of
R5833 T7685 T7693 arg1Of Transcription,were
R5834 T7685 T7695 arg2Of Transcription,detected
R5835 T7685 T7704 arg1Of Transcription,was
R5836 T7685 T7705 arg1Of Transcription,higher
R5837 T7687 T7688 arg1Of IL10,","
R5838 T7688 T7691 arg1Of ",",and
R5839 T7689 T7688 arg2Of IL15,","
R5840 T7691 T7686 arg2Of and,of
R5841 T7691 T7690 arg1Of and,","
R5842 T7692 T7691 arg2Of IFNγ,and
R5843 T7695 T7693 arg2Of detected,were
R5844 T7695 T7694 arg1Of detected,reproducibly
R5845 T7695 T7696 arg1Of detected,in
R5846 T7695 T7703 arg1Of detected,and
R5847 T7699 T7697 arg1Of lymphocytes,LMP1
R5848 T7699 T7698 arg1Of lymphocytes,transgenic
R5849 T7699 T7700 arg1Of lymphocytes,and
R5850 T7700 T7696 arg2Of and,in
R5851 T7702 T7700 arg2Of cells,and
R5852 T7702 T7701 arg1Of cells,lymphoma
R5853 T7704 T7703 arg2Of was,and
R5854 T7705 T7704 arg2Of higher,was
R5855 T7705 T7706 arg1Of higher,than
R5856 T7707 T7706 arg2Of in,than
R5857 T7713 T7709 arg1Of lines,B
R5858 T7713 T7710 arg1Of lines,cell
R5859 T7713 T7711 arg1Of lines,lymphoma
R5860 T7713 T7712 arg1Of lines,cell
R5861 T7714 T7715 arg1Of 967,and
R5862 T7715 T7707 arg2Of and,in
R5863 T7715 T7708 arg1Of and,the
R5864 T7715 T7713 arg1Of and,lines
R5865 T7715 T7717 arg1Of and,(
R5866 T7716 T7715 arg2Of K46μ,and
R5867 T7719 T7717 arg2Of 5A,(
R5868 T7719 T7718 arg1Of 5A,Figure
R5869 T7720 T7717 arg3Of ),(
R5870 T7721 T7722 arg1Of There,was
R5871 T7722 T7726 arg1Of was,in
R5872 T7722 T7740 arg1Of was,","
R5873 T7722 T7741 modOf was,suggesting
R5874 T7725 T7722 arg2Of difference,was
R5875 T7725 T7723 arg1Of difference,no
R5876 T7725 T7724 arg1Of difference,significant
R5877 T7728 T7726 arg2Of expression,in
R5878 T7728 T7727 arg1Of expression,the
R5879 T7728 T7729 arg1Of expression,of
R5880 T7730 T7731 arg1Of IL15,and
R5881 T7731 T7729 arg2Of and,of
R5882 T7731 T7733 arg1Of and,between
R5883 T7732 T7731 arg2Of IFNγ,and
R5884 T7736 T7734 arg1Of lymphocytes,LMP1
R5885 T7736 T7735 arg1Of lymphocytes,transgenic
R5886 T7736 T7737 arg1Of lymphocytes,and
R5887 T7737 T7733 arg2Of and,between
R5888 T7739 T7737 arg2Of cells,and
R5889 T7739 T7738 arg1Of cells,lymphoma
R5890 T7743 T7744 arg1Of upregulation,of
R5891 T7743 T7748 arg1Of upregulation,is
R5892 T7743 T7749 arg2Of upregulation,induced
R5893 T7743 T7757 arg1Of upregulation,is
R5894 T7745 T7746 arg1Of IL15,and
R5895 T7746 T7744 arg2Of and,of
R5896 T7747 T7746 arg2Of IFNγ,and
R5897 T7749 T7748 arg2Of induced,is
R5898 T7749 T7753 arg1Of induced,in
R5899 T7749 T7756 arg1Of induced,but
R5900 T7752 T7749 arg1Of expression,induced
R5901 T7752 T7750 arg2Of expression,by
R5902 T7752 T7751 arg1Of expression,LMP1
R5903 T7755 T7753 arg2Of lymphocytes,in
R5904 T7755 T7754 arg1Of lymphocytes,healthy
R5905 T7756 T7741 arg2Of but,suggesting
R5906 T7756 T7742 arg1Of but,that
R5907 T7757 T7756 arg2Of is,but
R5908 T7757 T7758 arg1Of is,not
R5909 T7761 T7757 arg2Of property,is
R5910 T7761 T7759 arg1Of property,a
R5911 T7761 T7760 arg1Of property,unique
R5912 T7761 T7762 arg1Of property,of
R5913 T7764 T7762 arg2Of lymphocytes,of
R5914 T7764 T7763 arg1Of lymphocytes,malignant
R5915 T7767 T7768 arg1Of IL10,","
R5916 T7767 T7775 arg1Of IL10,was
R5917 T7767 T7776 arg2Of IL10,increased
R5918 T7773 T7768 arg2Of cytokine,","
R5919 T7773 T7769 arg1Of cytokine,a
R5920 T7773 T7770 arg1Of cytokine,B
R5921 T7773 T7771 arg1Of cytokine,lymphocyte
R5922 T7773 T7772 arg1Of cytokine,stimulatory
R5923 T7776 T7765 arg1Of increased,Strikingly
R5924 T7776 T7766 arg1Of increased,","
R5925 T7776 T7774 arg1Of increased,","
R5926 T7776 T7775 arg2Of increased,was
R5927 T7776 T7779 arg1Of increased,5-fold
R5928 T7776 T7780 arg1Of increased,in
R5929 T7776 T7788 arg1Of increased,compared
R5930 T7779 T7777 arg1Of 5-fold,1.5-
R5931 T7779 T7778 arg1Of 5-fold,to
R5932 T7782 T7783 arg1Of wild-type,and
R5933 T7784 T7783 arg2Of LMP1,and
R5934 T7787 T7780 arg2Of cells,in
R5935 T7787 T7781 arg1Of cells,the
R5936 T7787 T7782 arg1Of cells,wild-type
R5937 T7787 T7784 arg1Of cells,LMP1
R5938 T7787 T7785 arg1Of cells,transgenic
R5939 T7787 T7786 arg1Of cells,lymphoma
R5940 T7789 T7788 arg2Of to,compared
R5941 T7792 T7789 arg2Of lymphocytes,to
R5942 T7792 T7790 arg1Of lymphocytes,LMP1
R5943 T7792 T7791 arg1Of lymphocytes,transgenic
R5944 T7792 T7793 arg1Of lymphocytes,(
R5945 T7795 T7793 arg2Of 5A,(
R5946 T7795 T7794 arg1Of 5A,Figure
R5947 T7796 T7793 arg3Of ),(
R5948 T7797 T7798 arg1Of Production,of
R5949 T7797 T7802 arg1Of Production,has
R5950 T7797 T7803 arg1Of Production,been
R5951 T7797 T7804 arg2Of Production,associated
R5952 T7799 T7800 arg1Of IL15,and
R5953 T7800 T7798 arg2Of and,of
R5954 T7801 T7800 arg2Of IFNγ,and
R5955 T7804 T7802 arg2Of associated,has
R5956 T7804 T7803 arg2Of associated,been
R5957 T7804 T7805 arg1Of associated,with
R5958 T7806 T7805 arg2Of induction,with
R5959 T7806 T7807 arg1Of induction,of
R5960 T7806 T7811 arg1Of induction,in
R5961 T7810 T7807 arg2Of responses,of
R5962 T7810 T7808 arg1Of responses,cytotoxic
R5963 T7810 T7809 arg1Of responses,effector
R5964 T7812 T7811 arg2Of cells,in
R5965 T7812 T7814 arg2Of cells,infected
R5966 T7814 T7813 arg1Of infected,latently
R5967 T7814 T7815 arg1Of infected,with
R5968 T7816 T7815 arg2Of EBV,with
R5969 T7816 T7817 arg1Of EBV,[
R5970 T7818 T7817 arg2Of "33,34",[
R5971 T7819 T7817 arg3Of ],[
R5972 T7822 T7823 arg1Of transformation,and
R5973 T7823 T7826 arg2Of and,induced
R5974 T7823 T7829 arg1Of and,are
R5975 T7823 T7830 arg2Of and,associated
R5976 T7825 T7823 arg2Of properties,and
R5977 T7825 T7824 arg1Of properties,growth
R5978 T7828 T7826 arg1Of EBV,induced
R5979 T7828 T7827 arg2Of EBV,by
R5980 T7830 T7820 arg1Of associated,However
R5981 T7830 T7821 arg1Of associated,","
R5982 T7830 T7829 arg2Of associated,are
R5983 T7830 T7831 arg1Of associated,with
R5984 T7830 T7839 arg1Of associated,;
R5985 T7833 T7831 arg2Of upregulation,with
R5986 T7833 T7832 arg1Of upregulation,the
R5987 T7833 T7834 arg1Of upregulation,of
R5988 T7835 T7834 arg2Of IL10,of
R5989 T7835 T7836 arg1Of IL10,[
R5990 T7837 T7836 arg2Of 35–38,[
R5991 T7838 T7836 arg3Of ],[
R5992 T7843 T7842 arg1Of effects,the
R5993 T7843 T7844 arg1Of effects,of
R5994 T7843 T7847 arg1Of effects,on
R5995 T7843 T7855 arg1Of effects,were
R5996 T7843 T7857 arg2Of effects,examined
R5997 T7846 T7844 arg2Of upregulation,of
R5998 T7846 T7845 arg1Of upregulation,IL10
R5999 T7850 T7847 arg2Of properties,on
R6000 T7850 T7848 arg1Of properties,the
R6001 T7850 T7849 arg1Of properties,growth
R6002 T7850 T7851 arg1Of properties,of
R6003 T7854 T7851 arg2Of cells,of
R6004 T7854 T7852 arg1Of cells,the
R6005 T7854 T7853 arg1Of cells,lymphoma
R6006 T7857 T7839 arg2Of examined,;
R6007 T7857 T7840 arg1Of examined,hence
R6008 T7857 T7841 arg1Of examined,","
R6009 T7857 T7855 arg2Of examined,were
R6010 T7857 T7856 arg1Of examined,further
R6011 T7859 T7858 arg1Of analysis,Immunoblot
R6012 T7859 T7860 arg1Of analysis,indicated
R6013 T7864 T7862 arg1Of lymphocytes,LMP1
R6014 T7864 T7863 arg1Of lymphocytes,transgenic
R6015 T7864 T7865 arg1Of lymphocytes,and
R6016 T7865 T7872 arg1Of and,had
R6017 T7865 T7880 arg1Of and,β
R6018 T7871 T7865 arg2Of cells,and
R6019 T7871 T7866 arg1Of cells,wild-type
R6020 T7871 T7867 arg1Of cells,and
R6021 T7871 T7868 arg1Of cells,LMP1
R6022 T7871 T7869 arg1Of cells,transgenic
R6023 T7871 T7870 arg1Of cells,lymphoma
R6024 T7872 T7879 arg1Of had,and
R6025 T7875 T7872 arg2Of levels,had
R6026 T7875 T7873 arg1Of levels,corresponding
R6027 T7875 T7874 arg2Of levels,increased
R6028 T7875 T7876 arg1Of levels,of
R6029 T7878 T7876 arg2Of α,of
R6030 T7878 T7877 arg2Of α,phosphorylated
R6031 T7879 T7860 arg2Of and,indicated
R6032 T7879 T7861 arg1Of and,that
R6033 T7880 T7879 arg2Of β,and
R6034 T7881 T7880 arg2Of isoforms,β
R6035 T7881 T7882 arg1Of isoforms,of
R6036 T7884 T7882 arg2Of Stat3,of
R6037 T7884 T7883 arg2Of Stat3,activated
R6038 T7884 T7885 arg1Of Stat3,","
R6039 T7887 T7885 arg2Of target,","
R6040 T7887 T7886 arg1Of target,a
R6041 T7887 T7888 arg1Of target,of
R6042 T7891 T7888 arg2Of receptor,of
R6043 T7891 T7889 arg1Of receptor,the
R6044 T7891 T7890 arg1Of receptor,IL10
R6045 T7891 T7892 arg1Of receptor,(
R6046 T7894 T7892 arg2Of 5B,(
R6047 T7894 T7893 arg1Of 5B,Figure
R6048 T7895 T7892 arg3Of ),(
R6049 T7899 T7898 arg2Of comparing,when
R6050 T7902 T7899 arg2Of lymphomas,comparing
R6051 T7902 T7900 arg1Of lymphomas,the
R6052 T7902 T7901 arg1Of lymphomas,same
R6053 T7904 T7899 arg1Of there,comparing
R6054 T7904 T7905 arg1Of there,was
R6055 T7905 T7896 arg1Of was,However
R6056 T7905 T7897 arg1Of was,","
R6057 T7905 T7898 arg1Of was,when
R6058 T7905 T7903 arg1Of was,","
R6059 T7907 T7905 arg2Of correlation,was
R6060 T7907 T7906 arg1Of correlation,no
R6061 T7907 T7908 arg1Of correlation,between
R6062 T7910 T7909 arg1Of levels,the
R6063 T7910 T7911 arg1Of levels,of
R6064 T7910 T7914 arg1Of levels,and
R6065 T7913 T7911 arg2Of induction,of
R6066 T7913 T7912 arg1Of induction,IL10
R6067 T7914 T7908 arg2Of and,between
R6068 T7916 T7914 arg2Of levels,and
R6069 T7916 T7915 arg1Of levels,the
R6070 T7916 T7917 arg1Of levels,of
R6071 T7919 T7917 arg2Of activation,of
R6072 T7919 T7918 arg1Of activation,Stat3
R6073 T7920 T7921 arg1Of This,suggests
R6074 T7924 T7923 arg1Of activation,the
R6075 T7924 T7925 arg1Of activation,of
R6076 T7924 T7927 arg1Of activation,is
R6077 T7924 T7930 arg2Of activation,induced
R6078 T7926 T7925 arg2Of Stat3,of
R6079 T7930 T7922 arg1Of induced,that
R6080 T7930 T7927 arg2Of induced,is
R6081 T7930 T7928 arg1Of induced,not
R6082 T7930 T7929 arg1Of induced,solely
R6083 T7930 T7933 arg1Of induced,or
R6084 T7932 T7930 arg1Of IL10,induced
R6085 T7932 T7931 arg2Of IL10,by
R6086 T7933 T7921 arg2Of or,suggests
R6087 T7934 T7933 arg2Of that,or
R6088 T7936 T7935 arg1Of activation,Stat3
R6089 T7936 T7937 arg1Of activation,may
R6090 T7936 T7938 arg1Of activation,be
R6091 T7936 T7939 arg1Of activation,constitutive
R6092 T7938 T7934 arg2Of be,that
R6093 T7938 T7937 arg2Of be,may
R6094 T7939 T7938 arg2Of constitutive,be
R6095 T7942 T7943 arg1Of there,was
R6096 T7943 T7940 arg1Of was,Additionally
R6097 T7943 T7941 arg1Of was,","
R6098 T7945 T7944 arg1Of correlation,no
R6099 T7945 T7946 arg1Of correlation,between
R6100 T7945 T7952 arg1Of correlation,and
R6101 T7948 T7946 arg2Of levels,between
R6102 T7948 T7947 arg1Of levels,the
R6103 T7948 T7949 arg1Of levels,of
R6104 T7951 T7949 arg2Of expression,of
R6105 T7951 T7950 arg1Of expression,LMP1
R6106 T7952 T7943 arg2Of and,was
R6107 T7954 T7952 arg2Of levels,and
R6108 T7954 T7953 arg1Of levels,the
R6109 T7954 T7955 arg1Of levels,of
R6110 T7957 T7955 arg2Of induction,of
R6111 T7957 T7956 arg1Of induction,IL10
R6112 T7957 T7958 arg1Of induction,(
R6113 T7960 T7961 arg1Of 1A,and
R6114 T7961 T7958 arg2Of and,(
R6115 T7961 T7959 arg1Of and,Figures
R6116 T7962 T7961 arg2Of 5A,and
R6117 T7963 T7958 arg3Of ),(
R6118 T7964 T7965 arg1Of This,indicates
R6119 T7968 T7967 arg1Of induction,the
R6120 T7968 T7969 arg1Of induction,of
R6121 T7968 T7971 arg1Of induction,is
R6122 T7968 T7980 arg1Of induction,may
R6123 T7968 T7982 arg1Of induction,be
R6124 T7968 T7984 arg2Of induction,affected
R6125 T7970 T7969 arg2Of IL10,of
R6126 T7971 T7979 arg1Of is,and
R6127 T7974 T7971 arg2Of property,is
R6128 T7974 T7972 arg1Of property,a
R6129 T7974 T7973 arg1Of property,general
R6130 T7974 T7975 arg2Of property,associated
R6131 T7975 T7976 arg1Of associated,with
R6132 T7978 T7976 arg2Of survival,with
R6133 T7978 T7977 arg2Of survival,enhanced
R6134 T7979 T7965 arg2Of and,indicates
R6135 T7979 T7966 arg1Of and,that
R6136 T7984 T7979 arg2Of affected,and
R6137 T7984 T7980 arg2Of affected,may
R6138 T7984 T7981 arg1Of affected,only
R6139 T7984 T7982 arg2Of affected,be
R6140 T7984 T7983 arg1Of affected,indirectly
R6141 T7986 T7984 arg1Of LMP1,affected
R6142 T7986 T7985 arg2Of LMP1,by
R6143 T7988 T7987 arg1Of antibodies,Neutralizing
R6144 T7988 T7989 arg1Of antibodies,to
R6145 T7988 T7991 arg1Of antibodies,did
R6146 T7988 T7993 arg1Of antibodies,affect
R6147 T7990 T7989 arg2Of IL10,to
R6148 T7993 T7991 arg2Of affect,did
R6149 T7993 T7992 arg1Of affect,not
R6150 T7993 T7999 arg1Of affect,as
R6151 T7993 T8009 arg1Of affect,","
R6152 T7993 T8010 modOf affect,suggesting
R6153 T7995 T7993 arg2Of survival,affect
R6154 T7995 T7994 arg1Of survival,the
R6155 T7995 T7996 arg1Of survival,of
R6156 T7998 T7996 arg2Of cells,of
R6157 T7998 T7997 arg1Of cells,lymphoma
R6158 T8000 T7999 arg2Of determined,as
R6159 T8004 T8000 arg1Of assay,determined
R6160 T8004 T8001 arg2Of assay,by
R6161 T8004 T8002 arg1Of assay,the
R6162 T8004 T8003 arg1Of assay,MTS
R6163 T8004 T8005 arg1Of assay,(
R6164 T8007 T8005 arg2Of data,(
R6165 T8007 T8006 arg1Of data,unpublished
R6166 T8008 T8005 arg3Of ),(
R6167 T8012 T8010 arg2Of activation,suggesting
R6168 T8012 T8011 arg1Of activation,constitutive
R6169 T8012 T8013 arg1Of activation,of
R6170 T8014 T8013 arg2Of Stat3,of
R6171 T8015 T8016 arg1Of This,was
R6172 T8015 T8017 arg2Of This,confirmed
R6173 T8017 T8016 arg2Of confirmed,was
R6174 T8017 T8030 arg1Of confirmed,","
R6175 T8020 T8017 arg1Of analysis,confirmed
R6176 T8020 T8018 arg2Of analysis,by
R6177 T8020 T8019 arg1Of analysis,immunoblot
R6178 T8020 T8022 arg1Of analysis,that
R6179 T8022 T8021 arg1Of that,such
R6180 T8022 T8023 arg1Of that,in
R6181 T8025 T8023 arg2Of presence,in
R6182 T8025 T8024 arg1Of presence,the
R6183 T8025 T8026 arg1Of presence,of
R6184 T8029 T8026 arg2Of antibodies,of
R6185 T8029 T8027 arg1Of antibodies,anti-IL10
R6186 T8029 T8028 arg1Of antibodies,neutralizing
R6187 T8032 T8031 arg1Of levels,pStat3
R6188 T8032 T8033 arg1Of levels,remained
R6189 T8032 T8034 arg2Of levels,activated
R6190 T8034 T8030 arg2Of activated,","
R6191 T8034 T8033 arg2Of activated,remained
R6192 T8034 T8035 arg1Of activated,in
R6193 T8037 T8035 arg2Of cells,in
R6194 T8037 T8036 arg1Of cells,lymphoma
R6195 T8037 T8038 arg2Of cells,isolated
R6196 T8038 T8039 arg1Of isolated,from
R6197 T8040 T8041 arg1Of wild-type,and
R6198 T8041 T8039 arg2Of and,from
R6199 T8044 T8041 arg2Of lymphomas,and
R6200 T8044 T8042 arg1Of lymphomas,LMP1
R6201 T8044 T8043 arg1Of lymphomas,transgenic
R6202 T8044 T8045 arg1Of lymphomas,(
R6203 T8047 T8045 arg2Of 5C,(
R6204 T8047 T8046 arg1Of 5C,Figure
R6205 T8048 T8045 arg3Of ),(
R6206 T8050 T8049 arg1Of addition,Exogenous
R6207 T8050 T8051 arg1Of addition,of
R6208 T8050 T8053 arg1Of addition,enhanced
R6209 T8052 T8051 arg2Of IL10,of
R6210 T8053 T8056 arg1Of enhanced,above
R6211 T8053 T8059 arg1Of enhanced,","
R6212 T8055 T8053 arg2Of activation,enhanced
R6213 T8055 T8054 arg1Of activation,pStat3
R6214 T8058 T8056 arg2Of levels,above
R6215 T8058 T8057 arg1Of levels,constitutive
R6216 T8060 T8053 arg3Of indicating,enhanced
R6217 T8063 T8062 arg1Of cells,lymphoma
R6218 T8063 T8064 arg1Of cells,are
R6219 T8063 T8065 arg1Of cells,responsive
R6220 T8064 T8060 arg2Of are,indicating
R6221 T8064 T8061 arg1Of are,that
R6222 T8065 T8064 arg2Of responsive,are
R6223 T8065 T8066 arg1Of responsive,to
R6224 T8068 T8066 arg2Of treatment,to
R6225 T8068 T8067 arg1Of treatment,IL10
R6226 T8068 T8069 arg1Of treatment,(
R6227 T8071 T8069 arg2Of 5C,(
R6228 T8071 T8070 arg1Of 5C,Figure
R6229 T8072 T8069 arg3Of ),(
R6230 T8073 T8074 arg1Of This,means
R6231 T8079 T8077 arg1Of cells,the
R6232 T8079 T8078 arg1Of cells,lymphoma
R6233 T8079 T8080 arg1Of cells,have
R6234 T8080 T8076 arg2Of have,although
R6235 T8083 T8080 arg2Of activation,have
R6236 T8083 T8081 arg1Of activation,constitutive
R6237 T8083 T8082 arg1Of activation,Stat3
R6238 T8085 T8086 arg1Of it,may
R6239 T8085 T8087 arg1Of it,be
R6240 T8085 T8089 arg2Of it,enhanced
R6241 T8089 T8074 arg2Of enhanced,means
R6242 T8089 T8075 arg1Of enhanced,that
R6243 T8089 T8076 arg1Of enhanced,although
R6244 T8089 T8084 arg1Of enhanced,","
R6245 T8089 T8086 arg2Of enhanced,may
R6246 T8089 T8087 arg2Of enhanced,be
R6247 T8089 T8088 arg1Of enhanced,further
R6248 T8092 T8089 arg1Of induction,enhanced
R6249 T8092 T8090 arg2Of induction,by
R6250 T8092 T8091 arg1Of induction,IL10
R6251 T8095 T8093 arg1Of effect,The
R6252 T8095 T8094 arg1Of effect,neutralizing
R6253 T8095 T8096 arg1Of effect,of
R6254 T8095 T8100 arg1Of effect,was
R6255 T8095 T8101 arg2Of effect,confirmed
R6256 T8099 T8096 arg2Of antibody,of
R6257 T8099 T8097 arg1Of antibody,the
R6258 T8099 T8098 arg1Of antibody,anti-IL10
R6259 T8101 T8100 arg2Of confirmed,was
R6260 T8101 T8109 arg1Of confirmed,compared
R6261 T8103 T8101 arg1Of pre-incubation,confirmed
R6262 T8103 T8102 arg2Of pre-incubation,by
R6263 T8103 T8104 arg1Of pre-incubation,of
R6264 T8103 T8106 arg1Of pre-incubation,with
R6265 T8105 T8104 arg2Of IL10,of
R6266 T8108 T8106 arg2Of antibody,with
R6267 T8108 T8107 arg1Of antibody,anti-IL10
R6268 T8110 T8109 arg2Of to,compared
R6269 T8115 T8110 arg2Of control,to
R6270 T8115 T8111 arg1Of control,a
R6271 T8115 T8112 arg1Of control,rat
R6272 T8115 T8113 arg1Of control,IgG1
R6273 T8115 T8114 arg1Of control,isotype
R6274 T8115 T8116 arg1Of control,(
R6275 T8118 T8116 arg2Of 5C,(
R6276 T8118 T8117 arg1Of 5C,Figure
R6277 T8119 T8116 arg3Of ),(
R6278 T8121 T8120 arg1Of translocation,Nuclear
R6279 T8121 T8122 arg1Of translocation,of
R6280 T8121 T8124 arg1Of translocation,is
R6281 T8123 T8122 arg2Of pStat3,of
R6282 T8124 T8130 arg1Of is,and
R6283 T8126 T8124 arg2Of consequence,is
R6284 T8126 T8125 arg1Of consequence,a
R6285 T8126 T8127 arg1Of consequence,of
R6286 T8128 T8127 arg2Of activation,of
R6287 T8130 T8129 arg1Of and,","
R6288 T8132 T8131 arg1Of pStat3,nuclear
R6289 T8132 T8133 arg1Of pStat3,was
R6290 T8132 T8135 arg2Of pStat3,detected
R6291 T8135 T8130 arg2Of detected,and
R6292 T8135 T8133 arg2Of detected,was
R6293 T8135 T8134 arg1Of detected,not
R6294 T8138 T8135 arg1Of staining,detected
R6295 T8138 T8136 arg2Of staining,by
R6296 T8138 T8137 arg1Of staining,immunohistochemistry
R6297 T8138 T8139 arg1Of staining,of
R6298 T8141 T8139 arg2Of sections,of
R6299 T8141 T8140 arg1Of sections,spleen
R6300 T8141 T8142 arg1Of sections,from
R6301 T8144 T8142 arg2Of mice,from
R6302 T8144 T8143 arg1Of mice,control
R6303 T8148 T8147 arg1Of pStat3,nuclear
R6304 T8148 T8149 arg1Of pStat3,was
R6305 T8148 T8150 arg1Of pStat3,detectable
R6306 T8148 T8159 arg1Of pStat3,was
R6307 T8148 T8160 arg2Of pStat3,detected
R6308 T8149 T8158 arg1Of was,and
R6309 T8150 T8149 arg2Of detectable,was
R6310 T8150 T8151 arg1Of detectable,in
R6311 T8154 T8152 arg1Of mice,LMP1
R6312 T8154 T8153 arg1Of mice,transgenic
R6313 T8154 T8155 arg1Of mice,and
R6314 T8155 T8151 arg2Of and,in
R6315 T8157 T8155 arg2Of lymphomas,and
R6316 T8157 T8156 arg1Of lymphomas,wild-type
R6317 T8158 T8145 arg1Of and,However
R6318 T8158 T8146 arg1Of and,","
R6319 T8160 T8158 arg2Of detected,and
R6320 T8160 T8159 arg2Of detected,was
R6321 T8160 T8162 arg1Of detected,homogeneously
R6322 T8160 T8163 arg1Of detected,in
R6323 T8162 T8161 arg1Of homogeneously,more
R6324 T8166 T8163 arg2Of lymphomas,in
R6325 T8166 T8164 arg1Of lymphomas,LMP1
R6326 T8166 T8165 arg1Of lymphomas,transgenic
R6327 T8166 T8167 arg1Of lymphomas,(
R6328 T8169 T8167 arg2Of 5D,(
R6329 T8169 T8168 arg1Of 5D,Figure
R6330 T8170 T8167 arg3Of ),(
R6331 T8173 T8171 arg1Of activation,The
R6332 T8173 T8172 arg1Of activation,constitutive
R6333 T8173 T8174 arg1Of activation,of
R6334 T8173 T8180 arg1Of activation,suggests
R6335 T8175 T8176 arg1Of pStat3,and
R6336 T8176 T8174 arg2Of and,of
R6337 T8179 T8176 arg2Of Stat3,and
R6338 T8179 T8177 arg1Of Stat3,abundant
R6339 T8179 T8178 arg1Of Stat3,nuclear
R6340 T8183 T8182 arg1Of signaling,Stat3
R6341 T8183 T8184 arg1Of signaling,contributes
R6342 T8184 T8180 arg2Of contributes,suggests
R6343 T8184 T8181 arg1Of contributes,that
R6344 T8184 T8185 arg1Of contributes,to
R6345 T8188 T8185 arg2Of development,to
R6346 T8188 T8186 arg1Of development,LMP1-mediated
R6347 T8188 T8187 arg1Of development,lymphoma
R7393 T9824 T9825 arg1Of LMP1,Activates
R7394 T9824 T9829 arg1Of LMP1,Deregulates
R7395 T9825 T9828 arg1Of Activates,and
R7396 T9827 T9825 arg2Of Signaling,Activates
R7397 T9827 T9826 arg1Of Signaling,Akt
R7398 T9829 T9828 arg2Of Deregulates,and
R7403 T9834 T9833 arg1Of Pathway,Cycle
R7404 T9836 T9835 arg1Of transformation,LMP1
R7405 T9836 T9837 arg1Of transformation,of
R7406 T9836 T9840 arg1Of transformation,requires
R7407 T9839 T9837 arg2Of fibroblasts,of
R7408 T9839 T9838 arg1Of fibroblasts,rodent
R7409 T9841 T9842 arg1Of activation,of
R7410 T9841 T9844 arg1Of activation,and
R7411 T9843 T9842 arg2Of PI3K,of
R7412 T9844 T9840 arg2Of and,requires
R7413 T9845 T9844 arg2Of Akt,and
R7414 T9845 T9846 arg1Of Akt,[
R7415 T9847 T9846 arg2Of 5,[
R7416 T9848 T9846 arg3Of ],[
R7417 T9852 T9851 arg2Of pAkt,activated
R7418 T9852 T9853 arg1Of pAkt,is
R7419 T9852 T9855 arg2Of pAkt,detected
R7420 T9855 T9849 arg1Of detected,Additionally
R7421 T9855 T9850 arg1Of detected,","
R7422 T9855 T9853 arg2Of detected,is
R7423 T9855 T9854 arg1Of detected,frequently
R7424 T9855 T9856 arg1Of detected,in
R7425 T9857 T9858 arg1Of NPC,and
R7426 T9858 T9856 arg2Of and,in
R7427 T9862 T9858 arg2Of cells,and
R7428 T9862 T9859 arg1Of cells,the
R7429 T9862 T9860 arg1Of cells,neoplastic
R7430 T9862 T9861 arg1Of cells,Reed-Sternberg
R7431 T9862 T9863 arg1Of cells,of
R7432 T9865 T9863 arg2Of HD,of
R7433 T9865 T9864 arg1Of HD,classical
R7434 T9865 T9866 arg1Of HD,[
R7435 T9867 T9866 arg2Of "39,40",[
R7436 T9868 T9866 arg3Of ],[
R7437 T9870 T9869 arg1Of determine,To
R7438 T9873 T9872 arg1Of signaling,Akt
R7439 T9873 T9874 arg1Of signaling,is
R7440 T9873 T9875 arg2Of signaling,activated
R7441 T9875 T9870 arg2Of activated,determine
R7442 T9875 T9871 arg1Of activated,if
R7443 T9875 T9874 arg2Of activated,is
R7444 T9875 T9876 arg1Of activated,in
R7445 T9879 T9876 arg2Of mice,in
R7446 T9879 T9877 arg1Of mice,LMP1
R7447 T9879 T9878 arg1Of mice,transgenic
R7448 T9881 T9882 arg1Of pAkt,and
R7449 T9882 T9887 arg1Of and,were
R7450 T9882 T9888 arg2Of and,assessed
R7451 T9883 T9882 arg2Of several,and
R7452 T9883 T9884 arg1Of several,of
R7453 T9886 T9884 arg2Of targets,of
R7454 T9886 T9885 arg1Of targets,its
R7455 T9888 T9869 modOf assessed,To
R7456 T9888 T9880 arg1Of assessed,","
R7457 T9888 T9887 arg2Of assessed,were
R7458 T9890 T9888 arg1Of immunoblotting,assessed
R7459 T9890 T9889 arg2Of immunoblotting,by
R7460 T9890 T9891 arg1Of immunoblotting,of
R7461 T9896 T9891 arg2Of cells,of
R7462 T9896 T9892 arg1Of cells,splenic
R7463 T9896 T9893 arg1Of cells,CD19+
R7464 T9896 T9894 arg1Of cells,MACS-purified
R7465 T9896 T9895 arg1Of cells,B
R7466 T9900 T9897 arg1Of cells,LMP1
R7467 T9900 T9898 arg1Of cells,transgenic
R7468 T9900 T9899 arg1Of cells,B
R7469 T9900 T9901 arg1Of cells,had
R7470 T9900 T9902 arg1Of cells,increased
R7471 T9902 T9901 arg2Of increased,had
R7472 T9902 T9906 arg1Of increased,compared
R7473 T9902 T9910 arg1Of increased,;
R7474 T9903 T9902 arg2Of levels,increased
R7475 T9903 T9904 arg1Of levels,of
R7476 T9905 T9904 arg2Of pAkt,of
R7477 T9907 T9906 arg2Of to,compared
R7478 T9909 T9907 arg2Of lymphocytes,to
R7479 T9909 T9908 arg1Of lymphocytes,wild-type
R7480 T9913 T9914 arg1Of progression,to
R7481 T9913 T9916 arg1Of progression,in
R7482 T9913 T9923 arg1Of progression,did
R7483 T9913 T9926 arg1Of progression,increase
R7484 T9915 T9914 arg2Of lymphoma,to
R7485 T9918 T9919 arg1Of LMP1-positive,and
R7486 T9920 T9919 arg2Of -negative,and
R7487 T9922 T9916 arg2Of cells,in
R7488 T9922 T9917 arg1Of cells,both
R7489 T9922 T9918 arg1Of cells,LMP1-positive
R7490 T9922 T9920 arg1Of cells,-negative
R7491 T9922 T9921 arg1Of cells,lymphoma
R7492 T9926 T9910 arg2Of increase,;
R7493 T9926 T9911 arg1Of increase,however
R7494 T9926 T9912 arg1Of increase,","
R7495 T9926 T9923 arg2Of increase,did
R7496 T9926 T9924 arg1Of increase,not
R7497 T9926 T9925 arg1Of increase,further
R7498 T9928 T9926 arg2Of levels,increase
R7499 T9928 T9927 arg1Of levels,pAkt
R7500 T9934 T9929 arg1Of kinase,The
R7501 T9934 T9930 arg1Of kinase,Akt
R7502 T9934 T9931 arg1Of kinase,target
R7503 T9934 T9932 arg1Of kinase,glycogen
R7504 T9934 T9933 arg1Of kinase,synthase
R7505 T9934 T9935 arg1Of kinase,3
R7506 T9934 T9936 arg1Of kinase,(
R7507 T9934 T9939 arg1Of kinase,is
R7508 T9934 T9940 arg2Of kinase,inactivated
R7509 T9937 T9936 arg2Of GSK3,(
R7510 T9938 T9936 arg3Of ),(
R7511 T9940 T9939 arg2Of inactivated,is
R7512 T9940 T9943 arg1Of inactivated,;
R7513 T9942 T9940 arg1Of phosphorylation,inactivated
R7514 T9942 T9941 arg2Of phosphorylation,by
R7515 T9948 T9946 arg2Of GSK3,increased
R7516 T9948 T9947 arg2Of GSK3,phosphorylated
R7517 T9948 T9949 arg1Of GSK3,was
R7518 T9948 T9951 arg2Of GSK3,detected
R7519 T9948 T9957 arg1Of GSK3,was
R7520 T9948 T9959 arg1Of GSK3,absent
R7521 T9951 T9949 arg2Of detected,was
R7522 T9951 T9950 arg1Of detected,not
R7523 T9951 T9952 arg1Of detected,in
R7524 T9951 T9956 arg1Of detected,and
R7525 T9955 T9952 arg2Of lymphocytes,in
R7526 T9955 T9953 arg1Of lymphocytes,the
R7527 T9955 T9954 arg1Of lymphocytes,transgenic
R7528 T9956 T9943 arg2Of and,;
R7529 T9956 T9944 arg1Of and,however
R7530 T9956 T9945 arg1Of and,","
R7531 T9957 T9956 arg2Of was,and
R7532 T9959 T9957 arg2Of absent,was
R7533 T9959 T9958 arg1Of absent,almost
R7534 T9959 T9960 arg1Of absent,in
R7535 T9963 T9960 arg2Of samples,in
R7536 T9963 T9961 arg1Of samples,the
R7537 T9963 T9962 arg1Of samples,lymphoma
R7538 T9963 T9964 arg1Of samples,(
R7539 T9966 T9964 arg2Of 6A,(
R7540 T9966 T9965 arg1Of 6A,Figure
R7541 T9967 T9964 arg3Of ),(
R7542 T9969 T9968 arg1Of finding,This
R7543 T9969 T9970 arg1Of finding,indicates
R7544 T9972 T9973 arg1Of GSK3,is
R7545 T9973 T9970 arg2Of is,indicates
R7546 T9973 T9971 arg1Of is,that
R7547 T9973 T9974 arg1Of is,not
R7548 T9976 T9973 arg2Of target,is
R7549 T9976 T9975 arg1Of target,a
R7550 T9976 T9977 arg1Of target,of
R7551 T9979 T9978 arg2Of Akt,activated
R7552 T9979 T9980 arg1Of Akt,in
R7553 T9979 T9985 arg1Of Akt,and
R7554 T9984 T9980 arg2Of lymphocytes,in
R7555 T9984 T9981 arg1Of lymphocytes,the
R7556 T9984 T9982 arg1Of lymphocytes,LMP1
R7557 T9984 T9983 arg1Of lymphocytes,transgenic
R7558 T9985 T9977 arg2Of and,of
R7559 T9987 T9985 arg2Of cells,and
R7560 T9987 T9986 arg1Of cells,lymphoma
R7561 T9990 T9991 arg1Of activation,of
R7562 T9990 T9993 arg1Of activation,without
R7563 T9990 T9997 arg1Of activation,has
R7564 T9990 T9998 arg1Of activation,been
R7565 T9990 T10000 arg2Of activation,shown
R7566 T9992 T9991 arg2Of Akt,of
R7567 T9994 T9993 arg2Of phosphorylation,without
R7568 T9994 T9995 arg1Of phosphorylation,of
R7569 T9996 T9995 arg2Of GSK3,of
R7570 T10000 T9988 arg1Of shown,Similarly
R7571 T10000 T9989 arg1Of shown,","
R7572 T10000 T9997 arg2Of shown,has
R7573 T10000 T9998 arg2Of shown,been
R7574 T10000 T9999 arg1Of shown,previously
R7575 T10000 T10001 arg1Of shown,in
R7576 T10003 T10001 arg2Of HD,in
R7577 T10003 T10002 arg1Of HD,EBV-positive
R7578 T10003 T10004 arg1Of HD,[
R7579 T10005 T10004 arg2Of 40,[
R7580 T10006 T10004 arg3Of ],[
R7581 T10008 T10007 arg2Of contrast,In
R7582 T10012 T10010 arg1Of lymphocytes,the
R7583 T10012 T10011 arg1Of lymphocytes,wild-type
R7584 T10012 T10013 arg1Of lymphocytes,lacked
R7585 T10012 T10017 arg1Of lymphocytes,did
R7586 T10012 T10018 arg1Of lymphocytes,have
R7587 T10013 T10016 arg1Of lacked,but
R7588 T10015 T10013 arg2Of Akt,lacked
R7589 T10015 T10014 arg2Of Akt,activated
R7590 T10016 T10007 arg1Of but,In
R7591 T10016 T10009 arg1Of but,","
R7592 T10018 T10016 arg2Of have,but
R7593 T10018 T10017 arg2Of have,did
R7594 T10021 T10018 arg2Of GSK3,have
R7595 T10021 T10019 arg1Of GSK3,detectable
R7596 T10021 T10020 arg2Of GSK3,phosphorylated
R7597 T10022 T10024 arg1Of This,suggests
R7598 T10024 T10023 arg1Of suggests,further
R7599 T10027 T10026 arg1Of pathways,additional
R7600 T10027 T10028 arg1Of pathways,are
R7601 T10027 T10029 arg2Of pathways,involved
R7602 T10029 T10024 arg2Of involved,suggests
R7603 T10029 T10025 arg1Of involved,that
R7604 T10029 T10028 arg2Of involved,are
R7605 T10029 T10030 arg1Of involved,in
R7606 T10032 T10030 arg2Of regulation,in
R7607 T10032 T10031 arg1Of regulation,the
R7608 T10032 T10033 arg1Of regulation,of
R7609 T10034 T10033 arg2Of GSK3,of
R7610 T10036 T10035 arg1Of identify,To
R7611 T10040 T10036 arg2Of targets,identify
R7612 T10040 T10037 arg1Of targets,other
R7613 T10040 T10038 arg1Of targets,potential
R7614 T10040 T10039 arg1Of targets,Akt
R7615 T10043 T10036 arg1Of analysis,identify
R7616 T10043 T10042 arg1Of analysis,immunoblot
R7617 T10043 T10044 arg1Of analysis,for
R7618 T10043 T10046 arg1Of analysis,was
R7619 T10043 T10047 arg2Of analysis,performed
R7620 T10045 T10044 arg2Of p-mTOR,for
R7621 T10047 T10035 modOf performed,To
R7622 T10047 T10041 arg1Of performed,","
R7623 T10047 T10046 arg2Of performed,was
R7624 T10049 T10048 arg2Of p-mTOR,Activated
R7625 T10049 T10050 arg1Of p-mTOR,was
R7626 T10049 T10052 arg2Of p-mTOR,increased
R7627 T10052 T10050 arg2Of increased,was
R7628 T10052 T10051 arg1Of increased,not
R7629 T10052 T10053 arg1Of increased,in
R7630 T10052 T10060 arg1Of increased,","
R7631 T10052 T10061 modOf increased,indicating
R7632 T10056 T10054 arg1Of lymphocytes,LMP1
R7633 T10056 T10055 arg1Of lymphocytes,transgenic
R7634 T10056 T10057 arg1Of lymphocytes,or
R7635 T10057 T10053 arg2Of or,in
R7636 T10059 T10057 arg2Of cells,or
R7637 T10059 T10058 arg1Of cells,lymphoma
R7638 T10064 T10063 arg1Of pathway,this
R7639 T10064 T10065 arg1Of pathway,is
R7640 T10064 T10067 arg2Of pathway,affected
R7641 T10064 T10073 arg1Of pathway,does
R7642 T10064 T10075 arg1Of pathway,contribute
R7643 T10067 T10065 arg2Of affected,is
R7644 T10067 T10066 arg1Of affected,not
R7645 T10067 T10072 arg1Of affected,and
R7646 T10071 T10067 arg1Of activation,affected
R7647 T10071 T10068 arg2Of activation,by
R7648 T10071 T10069 arg1Of activation,LMP1-induced
R7649 T10071 T10070 arg1Of activation,Akt
R7650 T10072 T10061 arg2Of and,indicating
R7651 T10072 T10062 arg1Of and,that
R7652 T10075 T10072 arg2Of contribute,and
R7653 T10075 T10073 arg2Of contribute,does
R7654 T10075 T10074 arg1Of contribute,not
R7655 T10075 T10076 arg1Of contribute,to
R7656 T10078 T10076 arg2Of development,to
R7657 T10078 T10077 arg1Of development,lymphoma
R7658 T10078 T10079 arg1Of development,(
R7659 T10081 T10079 arg2Of 6B,(
R7660 T10081 T10080 arg1Of 6B,Figure
R7661 T10082 T10079 arg3Of ),(
R7662 T10083 T10084 arg1Of Akt,is
R7663 T10083 T10086 arg2Of Akt,known
R7664 T10083 T10088 arg1Of Akt,phosphorylate
R7665 T10083 T10090 arg1Of Akt,induce
R7666 T10086 T10084 arg2Of known,is
R7667 T10086 T10085 arg1Of known,also
R7668 T10088 T10089 arg1Of phosphorylate,and
R7669 T10089 T10086 arg3Of and,known
R7670 T10089 T10087 arg1Of and,to
R7671 T10090 T10089 arg2Of induce,and
R7672 T10092 T10088 arg2Of degradation,phosphorylate
R7673 T10092 T10090 arg2Of degradation,induce
R7674 T10092 T10091 arg1Of degradation,the
R7675 T10092 T10093 arg1Of degradation,of
R7676 T10097 T10093 arg2Of family,of
R7677 T10097 T10094 arg1Of family,the
R7678 T10097 T10095 arg1Of family,pro-apoptotic
R7679 T10097 T10096 arg1Of family,Forkhead
R7680 T10097 T10098 arg1Of family,of
R7681 T10097 T10101 arg1Of family,","
R7682 T10097 T10102 arg1Of family,leading
R7683 T10100 T10098 arg2Of factors,of
R7684 T10100 T10099 arg1Of factors,transcription
R7685 T10102 T10103 arg1Of leading,to
R7686 T10106 T10104 arg1Of progression,cell
R7687 T10106 T10105 arg1Of progression,cycle
R7688 T10106 T10107 arg1Of progression,and
R7689 T10107 T10103 arg2Of and,to
R7690 T10107 T10109 arg1Of and,in
R7691 T10108 T10107 arg2Of survival,and
R7692 T10112 T10109 arg2Of tumors,in
R7693 T10112 T10110 arg1Of tumors,some
R7694 T10112 T10111 arg1Of tumors,human
R7695 T10112 T10113 arg1Of tumors,[
R7696 T10114 T10113 arg2Of "41,42",[
R7697 T10115 T10113 arg3Of ],[
R7698 T10117 T10116 arg1Of analysis,Immunoblot
R7699 T10117 T10118 arg1Of analysis,of
R7700 T10117 T10122 arg1Of analysis,did
R7701 T10117 T10125 arg1Of analysis,detect
R7702 T10121 T10118 arg2Of cells,of
R7703 T10121 T10119 arg1Of cells,splenic
R7704 T10121 T10120 arg1Of cells,B
R7705 T10125 T10122 arg2Of detect,did
R7706 T10125 T10123 arg1Of detect,not
R7707 T10125 T10124 arg1Of detect,consistently
R7708 T10127 T10125 arg2Of levels,detect
R7709 T10127 T10126 arg1Of levels,p-FoxO1
R7710 T10127 T10128 arg1Of levels,","
R7711 T10130 T10128 arg2Of signal,","
R7712 T10130 T10129 arg1Of signal,a
R7713 T10130 T10131 arg1Of signal,that
R7714 T10130 T10132 arg1Of signal,targets
R7715 T10132 T10134 arg1Of targets,for
R7716 T10133 T10132 arg2Of FoxO1,targets
R7717 T10135 T10134 arg2Of degradation,for
R7718 T10138 T10139 arg1Of degradation,of
R7719 T10138 T10141 arg1Of degradation,was
R7720 T10138 T10142 arg2Of degradation,assessed
R7721 T10140 T10139 arg2Of FoxO1,of
R7722 T10142 T10136 arg1Of assessed,Hence
R7723 T10142 T10137 arg1Of assessed,","
R7724 T10142 T10141 arg2Of assessed,was
R7725 T10144 T10142 arg1Of detection,assessed
R7726 T10144 T10143 arg2Of detection,by
R7727 T10144 T10145 arg1Of detection,of
R7728 T10148 T10145 arg2Of levels,of
R7729 T10148 T10146 arg1Of levels,total
R7730 T10148 T10147 arg1Of levels,FoxO1
R7731 T10150 T10149 arg1Of analysis,Immunoblot
R7732 T10150 T10151 arg1Of analysis,indicated
R7733 T10155 T10153 arg1Of levels,total
R7734 T10155 T10154 arg1Of levels,FoxO1
R7735 T10155 T10156 arg1Of levels,were
R7736 T10155 T10158 arg2Of levels,decreased
R7737 T10158 T10151 arg2Of decreased,indicated
R7738 T10158 T10152 arg1Of decreased,that
R7739 T10158 T10156 arg2Of decreased,were
R7740 T10158 T10157 arg1Of decreased,greatly
R7741 T10158 T10159 arg1Of decreased,in
R7742 T10158 T10169 arg1Of decreased,","
R7743 T10158 T10170 modOf decreased,suggesting
R7744 T10160 T10161 arg1Of wild-type,and
R7745 T10161 T10159 arg2Of and,in
R7746 T10164 T10161 arg2Of lymphomas,and
R7747 T10164 T10162 arg1Of lymphomas,LMP1
R7748 T10164 T10163 arg1Of lymphomas,transgenic
R7749 T10164 T10165 arg1Of lymphomas,(
R7750 T10167 T10165 arg2Of 6B,(
R7751 T10167 T10166 arg1Of 6B,Figure
R7752 T10168 T10165 arg3Of ),(
R7753 T10172 T10173 arg1Of inhibition,of
R7754 T10172 T10178 arg1Of inhibition,is
R7755 T10177 T10173 arg2Of pathway,of
R7756 T10177 T10174 arg1Of pathway,the
R7757 T10177 T10175 arg1Of pathway,Forkhead
R7758 T10177 T10176 arg1Of pathway,signaling
R7759 T10178 T10170 arg2Of is,suggesting
R7760 T10178 T10171 arg1Of is,that
R7761 T10181 T10178 arg2Of target,is
R7762 T10181 T10179 arg1Of target,an
R7763 T10181 T10180 arg1Of target,important
R7764 T10181 T10182 arg1Of target,of
R7765 T10181 T10184 arg1Of target,in
R7766 T10183 T10182 arg2Of Akt,of
R7767 T10186 T10184 arg2Of development,in
R7768 T10186 T10185 arg1Of development,lymphoma
R7769 T10192 T10191 arg1Of activation,Akt
R7770 T10192 T10193 arg1Of activation,did
R7771 T10192 T10195 arg1Of activation,induce
R7772 T10195 T10189 arg2Of induce,considering
R7773 T10195 T10190 arg1Of induce,that
R7774 T10195 T10193 arg2Of induce,did
R7775 T10195 T10194 arg1Of induce,not
R7776 T10195 T10198 arg1Of induce,in
R7777 T10197 T10195 arg2Of degradation,induce
R7778 T10197 T10196 arg1Of degradation,FoxO1
R7779 T10202 T10198 arg2Of cells,in
R7780 T10202 T10199 arg1Of cells,LMP1
R7781 T10202 T10200 arg1Of cells,transgenic
R7782 T10202 T10201 arg1Of cells,B
R7783 T10204 T10189 arg1Of Akt,considering
R7784 T10204 T10205 arg1Of Akt,may
R7785 T10204 T10207 arg1Of Akt,be
R7786 T10207 T10205 arg2Of be,may
R7787 T10207 T10206 arg1Of be,not
R7788 T10207 T10214 arg1Of be,and
R7789 T10210 T10207 arg2Of regulator,be
R7790 T10210 T10208 arg1Of regulator,the
R7791 T10210 T10209 arg1Of regulator,sole
R7792 T10210 T10211 arg1Of regulator,of
R7793 T10212 T10211 arg2Of FoxO1,of
R7794 T10214 T10187 arg1Of and,However
R7795 T10214 T10188 arg1Of and,","
R7796 T10214 T10189 modOf and,considering
R7797 T10214 T10203 arg1Of and,","
R7798 T10214 T10213 arg1Of and,","
R7799 T10215 T10216 arg1Of it,may
R7800 T10215 T10217 arg1Of it,be
R7801 T10217 T10214 arg2Of be,and
R7802 T10217 T10216 arg2Of be,may
R7803 T10219 T10220 arg1Of progression,to
R7804 T10219 T10222 arg1Of progression,requires
R7805 T10221 T10220 arg2Of lymphoma,to
R7806 T10222 T10217 arg2Of requires,be
R7807 T10222 T10218 arg1Of requires,that
R7808 T10223 T10222 arg2Of modulation,requires
R7809 T10223 T10224 arg1Of modulation,of
R7810 T10226 T10224 arg2Of pathways,of
R7811 T10226 T10225 arg1Of pathways,multiple
R7812 T10229 T10227 arg1Of family,The
R7813 T10229 T10228 arg1Of family,Forkhead
R7814 T10229 T10230 arg1Of family,of
R7815 T10229 T10233 arg1Of family,is
R7816 T10229 T10234 arg2Of family,known
R7817 T10229 T10236 arg1Of family,induce
R7818 T10232 T10230 arg2Of factors,of
R7819 T10232 T10231 arg1Of factors,transcription
R7820 T10234 T10233 arg2Of known,is
R7821 T10236 T10234 arg3Of induce,known
R7822 T10236 T10235 arg1Of induce,to
R7823 T10236 T10244 arg1Of induce,[
R7824 T10238 T10236 arg2Of expression,induce
R7825 T10238 T10237 arg1Of expression,the
R7826 T10238 T10239 arg1Of expression,of
R7827 T10243 T10239 arg2Of p27,of
R7828 T10243 T10240 arg1Of p27,the
R7829 T10243 T10241 arg1Of p27,Cdk
R7830 T10243 T10242 arg1Of p27,inhibitor
R7831 T10245 T10244 arg2Of "43,44",[
R7832 T10246 T10244 arg3Of ],[
R7833 T10249 T10247 arg1Of fibroblasts,LMP1-transformed
R7834 T10249 T10248 arg1Of fibroblasts,rodent
R7835 T10249 T10250 arg1Of fibroblasts,have
R7836 T10249 T10251 arg1Of fibroblasts,decreased
R7837 T10251 T10250 arg2Of decreased,have
R7838 T10251 T10271 arg1Of decreased,[
R7839 T10252 T10251 arg2Of expression,decreased
R7840 T10252 T10253 arg1Of expression,of
R7841 T10252 T10265 arg1Of expression,of
R7842 T10254 T10255 arg1Of p27,","
R7843 T10255 T10260 arg1Of ",",and
R7844 T10256 T10255 arg2Of upregulation,","
R7845 T10256 T10257 arg1Of upregulation,of
R7846 T10258 T10257 arg2Of Cdk2,of
R7847 T10260 T10253 arg2Of and,of
R7848 T10260 T10259 arg1Of and,","
R7849 T10262 T10263 arg1Of phosphorylation,and
R7850 T10263 T10260 arg2Of and,and
R7851 T10263 T10261 arg1Of and,subsequent
R7852 T10264 T10263 arg2Of inactivation,and
R7853 T10270 T10265 arg2Of Rb,of
R7854 T10270 T10266 arg1Of Rb,the
R7855 T10270 T10267 arg1Of Rb,tumor
R7856 T10270 T10268 arg1Of Rb,suppressor
R7857 T10270 T10269 arg1Of Rb,gene
R7858 T10272 T10271 arg2Of 45,[
R7859 T10273 T10271 arg3Of ],[
R7860 T10275 T10274 arg1Of investigate,To
R7861 T10277 T10278 arg1Of LMP1,affected
R7862 T10278 T10275 arg2Of affected,investigate
R7863 T10278 T10276 arg1Of affected,whether
R7864 T10281 T10278 arg2Of regulation,affected
R7865 T10281 T10279 arg1Of regulation,cell
R7866 T10281 T10280 arg1Of regulation,cycle
R7867 T10281 T10282 arg1Of regulation,through
R7868 T10281 T10286 arg1Of regulation,in
R7869 T10285 T10282 arg2Of pathway,through
R7870 T10285 T10283 arg1Of pathway,the
R7871 T10285 T10284 arg1Of pathway,Rb
R7872 T10288 T10286 arg2Of cells,in
R7873 T10288 T10287 arg1Of cells,B
R7874 T10291 T10275 arg1Of analyses,investigate
R7875 T10291 T10290 arg1Of analyses,immunoblot
R7876 T10291 T10292 arg1Of analyses,for
R7877 T10291 T10299 arg1Of analyses,were
R7878 T10291 T10300 arg2Of analyses,performed
R7879 T10293 T10294 arg1Of pRb,","
R7880 T10294 T10297 arg1Of ",",and
R7881 T10295 T10294 arg2Of Cdk2,","
R7882 T10297 T10292 arg2Of and,for
R7883 T10297 T10296 arg1Of and,","
R7884 T10298 T10297 arg2Of p27,and
R7885 T10300 T10274 modOf performed,To
R7886 T10300 T10289 arg1Of performed,","
R7887 T10300 T10299 arg2Of performed,were
R7888 T10300 T10301 arg1Of performed,on
R7889 T10306 T10301 arg2Of cells,on
R7890 T10306 T10302 arg1Of cells,splenic
R7891 T10306 T10303 arg1Of cells,CD19+
R7892 T10306 T10304 arg1Of cells,MACS-purified
R7893 T10306 T10305 arg1Of cells,B
R7894 T10310 T10307 arg1Of cells,LMP1
R7895 T10310 T10308 arg1Of cells,transgenic
R7896 T10310 T10309 arg1Of cells,B
R7897 T10310 T10311 arg1Of cells,had
R7898 T10310 T10312 arg1Of cells,enhanced
R7899 T10312 T10311 arg2Of enhanced,had
R7900 T10312 T10325 arg1Of enhanced,compared
R7901 T10313 T10312 arg2Of levels,enhanced
R7902 T10313 T10314 arg1Of levels,of
R7903 T10315 T10314 arg2Of pRb,of
R7904 T10315 T10316 arg1Of pRb,with
R7905 T10318 T10317 arg1Of stabilization,concomitant
R7906 T10318 T10319 arg1Of stabilization,of
R7907 T10318 T10323 arg1Of stabilization,and
R7908 T10322 T10319 arg2Of levels,of
R7909 T10322 T10320 arg1Of levels,total
R7910 T10322 T10321 arg1Of levels,Rb
R7911 T10323 T10316 arg2Of and,with
R7912 T10324 T10323 arg2Of Cdk2,and
R7913 T10326 T10325 arg2Of to,compared
R7914 T10329 T10326 arg2Of lymphocytes,to
R7915 T10329 T10327 arg1Of lymphocytes,wild-type
R7916 T10329 T10328 arg1Of lymphocytes,B
R7917 T10329 T10330 arg1Of lymphocytes,(
R7918 T10332 T10330 arg2Of 6C,(
R7919 T10332 T10331 arg1Of 6C,Figure
R7920 T10333 T10330 arg3Of ),(
R7921 T10334 T10335 arg1Of Progression,to
R7922 T10334 T10337 arg1Of Progression,in
R7923 T10334 T10345 arg1Of Progression,led
R7924 T10334 T10359 arg1Of Progression,decreased
R7925 T10336 T10335 arg2Of lymphoma,to
R7926 T10344 T10337 arg2Of cells,in
R7927 T10344 T10338 arg1Of cells,both
R7928 T10344 T10339 arg1Of cells,wild-type
R7929 T10344 T10340 arg1Of cells,and
R7930 T10344 T10341 arg1Of cells,LMP1
R7931 T10344 T10342 arg1Of cells,transgenic
R7932 T10344 T10343 arg1Of cells,lymphoma
R7933 T10345 T10346 arg1Of led,to
R7934 T10345 T10358 arg1Of led,and
R7935 T10348 T10346 arg2Of levels,to
R7936 T10348 T10347 arg2Of levels,increased
R7937 T10348 T10349 arg1Of levels,of
R7938 T10350 T10349 arg2Of Rb,of
R7939 T10350 T10351 arg1Of Rb,","
R7940 T10354 T10351 arg2Of levels,","
R7941 T10354 T10352 arg1Of levels,correspondingly
R7942 T10354 T10353 arg1Of levels,high
R7943 T10354 T10355 arg1Of levels,of
R7944 T10356 T10355 arg2Of Cdk2,of
R7945 T10358 T10357 arg1Of and,","
R7946 T10359 T10358 arg2Of decreased,and
R7947 T10360 T10359 arg2Of levels,decreased
R7948 T10360 T10361 arg1Of levels,of
R7949 T10360 T10363 arg1Of levels,(
R7950 T10362 T10361 arg2Of p27,of
R7951 T10365 T10363 arg2Of 6C,(
R7952 T10365 T10364 arg1Of 6C,Figure
R7953 T10366 T10363 arg3Of ),(
R7954 T10368 T10367 arg1Of data,These
R7955 T10368 T10369 arg1Of data,indicate
R7956 T10373 T10371 arg1Of pathway,the
R7957 T10373 T10372 arg1Of pathway,Rb
R7958 T10373 T10374 arg1Of pathway,is
R7959 T10373 T10375 arg2Of pathway,deregulated
R7960 T10375 T10370 arg1Of deregulated,that
R7961 T10375 T10374 arg2Of deregulated,is
R7962 T10375 T10376 arg1Of deregulated,in
R7963 T10375 T10380 arg1Of deregulated,and
R7964 T10379 T10376 arg2Of lymphocytes,in
R7965 T10379 T10377 arg1Of lymphocytes,LMP1
R7966 T10379 T10378 arg1Of lymphocytes,transgenic
R7967 T10380 T10369 arg2Of and,indicate
R7968 T10381 T10380 arg2Of that,and
R7969 T10383 T10382 arg1Of cells,lymphoma
R7970 T10383 T10384 arg1Of cells,are
R7971 T10383 T10385 arg2Of cells,distinguished
R7972 T10385 T10381 arg2Of distinguished,that
R7973 T10385 T10384 arg2Of distinguished,are
R7974 T10387 T10385 arg1Of loss,distinguished
R7975 T10387 T10386 arg2Of loss,by
R7976 T10387 T10388 arg1Of loss,of
R7977 T10389 T10390 arg1Of FoxO1,and
R7978 T10390 T10388 arg2Of and,of
R7979 T10392 T10390 arg2Of p27,and
R7980 T10392 T10391 arg2Of p27,decreased
R8882 T11897 T11898 arg1Of LMP1,Promotes
R8883 T11898 T11903 arg1Of Promotes,through
R8884 T11900 T11901 arg1Of Growth,and
R8885 T11901 T11898 arg2Of and,Promotes
R8886 T11901 T11899 arg1Of and,Tumor
R8887 T11902 T11901 arg2Of Survival,and
R8888 T11904 T11903 arg2Of Activation,through
R8889 T11904 T11905 arg1Of Activation,of
R8890 T11906 T11907 arg1Of Akt,","
R8891 T11907 T11910 arg1Of ",",and
R8892 T11908 T11907 arg2Of NFκB,","
R8893 T11910 T11905 arg2Of and,of
R8894 T11910 T11909 arg1Of and,","
R8895 T11912 T11910 arg2Of Pathways,and
R8896 T11912 T11911 arg1Of Pathways,Stat3
R8897 T11914 T11913 arg1Of explore,To
R8898 T11915 T11914 arg2Of which,explore
R8899 T11916 T11915 arg1Of pathways,which
R8900 T11916 T11917 arg1Of pathways,were
R8901 T11916 T11918 arg2Of pathways,required
R8902 T11918 T11917 arg2Of required,were
R8903 T11918 T11919 arg1Of required,for
R8904 T11922 T11923 arg1Of growth,and
R8905 T11923 T11919 arg2Of and,for
R8906 T11923 T11920 arg1Of and,the
R8907 T11923 T11921 arg2Of and,enhanced
R8908 T11923 T11925 arg1Of and,of
R8909 T11924 T11923 arg2Of survival,and
R8910 T11927 T11925 arg2Of lymphomas,of
R8911 T11927 T11926 arg1Of lymphomas,LMP1-induced
R8912 T11929 T11914 arg1Of splenocytes,explore
R8913 T11929 T11930 arg1Of splenocytes,from
R8914 T11929 T11936 arg1Of splenocytes,were
R8915 T11929 T11937 arg2Of splenocytes,cultured
R8916 T11931 T11932 arg1Of wild-type,and
R8917 T11932 T11930 arg2Of and,from
R8918 T11935 T11932 arg2Of mice,and
R8919 T11935 T11933 arg1Of mice,LMP1
R8920 T11935 T11934 arg1Of mice,transgenic
R8921 T11937 T11913 modOf cultured,To
R8922 T11937 T11928 arg1Of cultured,","
R8923 T11937 T11936 arg2Of cultured,were
R8924 T11937 T11938 arg1Of cultured,in
R8925 T11940 T11938 arg2Of presence,in
R8926 T11940 T11939 arg1Of presence,the
R8927 T11940 T11941 arg1Of presence,of
R8928 T11942 T11941 arg2Of inhibitors,of
R8929 T11942 T11943 arg1Of inhibitors,for
R8930 T11942 T11955 arg2Of inhibitors,assayed
R8931 T11943 T11954 arg1Of for,and
R8932 T11944 T11945 arg1Of Akt,","
R8933 T11945 T11947 arg1Of ",",","
R8934 T11946 T11945 arg2Of NFκB,","
R8935 T11947 T11949 arg1Of ",",","
R8936 T11948 T11947 arg2Of Stat3,","
R8937 T11949 T11952 arg1Of ",",or
R8938 T11950 T11949 arg2Of mTOR,","
R8939 T11952 T11943 arg2Of or,for
R8940 T11952 T11951 arg1Of or,","
R8941 T11953 T11952 arg2Of MAPK,or
R8942 T11955 T11954 arg2Of assayed,and
R8943 T11955 T11956 arg1Of assayed,for
R8944 T11957 T11958 arg1Of growth,and
R8945 T11958 T11956 arg2Of and,for
R8946 T11958 T11960 arg1Of and,by
R8947 T11959 T11958 arg2Of survival,and
R8948 T11963 T11960 arg2Of assay,by
R8949 T11963 T11961 arg1Of assay,the
R8950 T11963 T11962 arg1Of assay,MTS
R8951 T11966 T11964 arg2Of shown,As
R8952 T11966 T11965 arg1Of shown,previously
R8953 T11969 T11968 arg1Of lymphocytes,wild-type
R8954 T11969 T11970 arg1Of lymphocytes,were
R8955 T11969 T11972 arg1Of lymphocytes,viable
R8956 T11969 T11976 arg1Of lymphocytes,could
R8957 T11969 T11978 arg1Of lymphocytes,be
R8958 T11969 T11979 arg2Of lymphocytes,tested
R8959 T11970 T11971 arg1Of were,not
R8960 T11970 T11973 arg1Of were,in
R8961 T11970 T11975 arg1Of were,and
R8962 T11972 T11970 arg2Of viable,were
R8963 T11974 T11973 arg2Of culture,in
R8964 T11975 T11964 arg1Of and,As
R8965 T11975 T11967 arg1Of and,","
R8966 T11979 T11975 arg2Of tested,and
R8967 T11979 T11976 arg2Of tested,could
R8968 T11979 T11977 arg1Of tested,not
R8969 T11979 T11978 arg2Of tested,be
R8970 T11979 T11980 arg1Of tested,with
R8971 T11982 T11980 arg2Of inhibitors,with
R8972 T11982 T11981 arg1Of inhibitors,the
R8973 T11987 T11985 arg1Of viability,the
R8974 T11987 T11986 arg2Of viability,enhanced
R8975 T11987 T11988 arg1Of viability,of
R8976 T11987 T11992 arg1Of viability,was
R8977 T11987 T11994 arg2Of viability,blocked
R8978 T11991 T11988 arg2Of lymphocytes,of
R8979 T11991 T11989 arg1Of lymphocytes,LMP1
R8980 T11991 T11990 arg1Of lymphocytes,transgenic
R8981 T11994 T11983 arg1Of blocked,However
R8982 T11994 T11984 arg1Of blocked,","
R8983 T11994 T11992 arg2Of blocked,was
R8984 T11994 T11993 arg1Of blocked,effectively
R8985 T11994 T11997 arg1Of blocked,with
R8986 T11994 T12007 arg1Of blocked,with
R8987 T11994 T12012 arg1Of blocked,by
R8988 T11996 T11994 arg1Of treatment,blocked
R8989 T11996 T11995 arg2Of treatment,by
R8990 T11997 T12005 arg1Of with,and
R8991 T11998 T11999 arg1Of triciribine,","
R8992 T11999 T12001 arg1Of ",",","
R8993 T12000 T11999 arg2Of BAY11–7085,","
R8994 T12001 T11997 arg2Of ",",with
R8995 T12003 T12001 arg2Of I,","
R8996 T12003 T12002 arg1Of I,cucurbitacin
R8997 T12005 T12004 arg1Of and,","
R8998 T12005 T12010 arg1Of and,but
R8999 T12007 T12005 arg2Of with,and
R9000 T12007 T12006 arg1Of with,slightly
R9001 T12008 T12007 arg2Of SB203580,with
R9002 T12010 T12009 arg1Of but,","
R9003 T12012 T12010 arg2Of by,but
R9004 T12012 T12011 arg1Of by,not
R9005 T12013 T12012 arg2Of treatment,by
R9006 T12013 T12014 arg1Of treatment,with
R9007 T12015 T12016 arg1Of rapamycin,","
R9008 T12016 T12019 arg1Of ",",or
R9009 T12017 T12016 arg2Of U0126,","
R9010 T12019 T12014 arg2Of or,with
R9011 T12019 T12018 arg1Of or,","
R9012 T12020 T12019 arg2Of AG490,or
R9013 T12020 T12021 arg1Of AG490,(
R9014 T12022 T12021 arg2Of Figure,(
R9015 T12022 T12023 arg1Of Figure,7
R9016 T12024 T12021 arg3Of ),(
R9017 T12025 T12026 arg1Of Triciribine,inhibits
R9018 T12025 T12035 arg1Of Triciribine,has
R9019 T12025 T12036 arg1Of Triciribine,been
R9020 T12025 T12037 arg2Of Triciribine,shown
R9021 T12025 T12039 arg1Of Triciribine,induce
R9022 T12026 T12031 arg1Of inhibits,and
R9023 T12028 T12026 arg2Of activation,inhibits
R9024 T12028 T12027 arg1Of activation,the
R9025 T12028 T12029 arg1Of activation,of
R9026 T12030 T12029 arg2Of Akt,of
R9027 T12034 T12032 arg2Of μM,at
R9028 T12034 T12033 arg1Of μM,20
R9029 T12037 T12031 arg2Of shown,and
R9030 T12037 T12032 arg1Of shown,at
R9031 T12037 T12035 arg2Of shown,has
R9032 T12037 T12036 arg2Of shown,been
R9033 T12039 T12037 arg3Of induce,shown
R9034 T12039 T12038 arg1Of induce,to
R9035 T12041 T12039 arg2Of arrest,induce
R9036 T12041 T12040 arg1Of arrest,growth
R9037 T12041 T12042 arg1Of arrest,in
R9038 T12041 T12045 arg1Of arrest,with
R9039 T12044 T12042 arg2Of cells,in
R9040 T12044 T12043 arg1Of cells,cancer
R9041 T12048 T12045 arg2Of activity,with
R9042 T12048 T12046 arg1Of activity,aberrant
R9043 T12048 T12047 arg1Of activity,Akt
R9044 T12048 T12049 arg1Of activity,[
R9045 T12050 T12049 arg2Of 46,[
R9046 T12051 T12049 arg3Of ],[
R9047 T12053 T12052 arg1Of effects,The
R9048 T12053 T12054 arg1Of effects,of
R9049 T12053 T12056 arg1Of effects,on
R9050 T12053 T12065 arg1Of effects,were
R9051 T12053 T12066 arg1Of effects,apparent
R9052 T12055 T12054 arg2Of triciribine,of
R9053 T12058 T12056 arg2Of growth,on
R9054 T12058 T12057 arg1Of growth,cell
R9055 T12058 T12059 arg1Of growth,of
R9056 T12062 T12063 arg1Of lymphocytes,and
R9057 T12063 T12059 arg2Of and,of
R9058 T12063 T12060 arg1Of and,the
R9059 T12063 T12061 arg1Of and,transgenic
R9060 T12064 T12063 arg2Of lymphomas,and
R9061 T12065 T12067 arg1Of were,as
R9062 T12065 T12072 arg1Of were,","
R9063 T12065 T12073 modOf were,suggesting
R9064 T12066 T12065 arg2Of apparent,were
R9065 T12067 T12068 arg1Of as,low
R9066 T12067 T12069 arg1Of as,as
R9067 T12071 T12069 arg2Of μM,as
R9068 T12071 T12070 arg1Of μM,1
R9069 T12075 T12076 arg1Of activation,of
R9070 T12075 T12078 arg1Of activation,is
R9071 T12075 T12079 arg2Of activation,required
R9072 T12077 T12076 arg2Of Akt,of
R9073 T12079 T12073 arg2Of required,suggesting
R9074 T12079 T12074 arg1Of required,that
R9075 T12079 T12078 arg2Of required,is
R9076 T12079 T12080 arg1Of required,for
R9077 T12082 T12083 arg1Of survival,and
R9078 T12083 T12080 arg2Of and,for
R9079 T12083 T12081 arg1Of and,the
R9080 T12083 T12085 arg1Of and,of
R9081 T12084 T12083 arg2Of growth,and
R9082 T12088 T12086 arg1Of lymphocytes,LMP1
R9083 T12088 T12087 arg1Of lymphocytes,transgenic
R9084 T12088 T12089 arg1Of lymphocytes,and
R9085 T12089 T12085 arg2Of and,of
R9086 T12091 T12089 arg2Of cells,and
R9087 T12091 T12090 arg1Of cells,lymphoma
R9088 T12091 T12092 arg1Of cells,(
R9089 T12093 T12092 arg2Of Figure,(
R9090 T12093 T12094 arg1Of Figure,7
R9091 T12095 T12092 arg3Of ),(
R9092 T12097 T12096 arg1Of effects,The
R9093 T12097 T12098 arg1Of effects,of
R9094 T12097 T12101 arg1Of effects,were
R9095 T12097 T12102 arg2Of effects,assessed
R9096 T12100 T12098 arg2Of inhibitors,of
R9097 T12100 T12099 arg1Of inhibitors,the
R9098 T12102 T12101 arg2Of assessed,were
R9099 T12102 T12103 arg1Of assessed,by
R9100 T12104 T12103 arg2Of identifying,by
R9101 T12106 T12105 arg2Of Akt,phosphorylated
R9102 T12106 T12107 arg1Of Akt,","
R9103 T12107 T12110 arg1Of ",",and
R9104 T12108 T12107 arg2Of Stat3,","
R9105 T12110 T12104 arg2Of and,identifying
R9106 T12110 T12109 arg1Of and,","
R9107 T12112 T12110 arg2Of levels,and
R9108 T12112 T12111 arg1Of levels,total
R9109 T12112 T12113 arg1Of levels,of
R9110 T12114 T12113 arg2Of IκBα,of
R9111 T12114 T12115 arg1Of IκBα,(
R9112 T12116 T12115 arg2Of Figure,(
R9113 T12116 T12117 arg1Of Figure,8
R9114 T12118 T12115 arg3Of ),(
R9115 T12119 T12120 arg1Of Treatment,with
R9116 T12119 T12123 arg1Of Treatment,blocked
R9117 T12121 T12120 arg2Of triciribine,with
R9118 T12123 T12122 arg1Of blocked,effectively
R9119 T12123 T12128 arg1Of blocked,and
R9120 T12124 T12123 arg2Of phosphorylation,blocked
R9121 T12124 T12125 arg1Of phosphorylation,of
R9122 T12126 T12125 arg2Of Akt,of
R9123 T12128 T12127 arg1Of and,","
R9124 T12130 T12129 arg2Of Akt,phosphorylated
R9125 T12130 T12131 arg1Of Akt,was
R9126 T12130 T12134 arg2Of Akt,detected
R9127 T12133 T12132 arg1Of longer,no
R9128 T12134 T12128 arg2Of detected,and
R9129 T12134 T12131 arg2Of detected,was
R9130 T12134 T12133 arg1Of detected,longer
R9131 T12134 T12135 arg1Of detected,past
R9132 T12137 T12135 arg2Of μM,past
R9133 T12137 T12136 arg1Of μM,5
R9134 T12139 T12140 arg1Of Stat3,and
R9135 T12140 T12138 arg2Of and,Phosphorylated
R9136 T12140 T12142 arg1Of and,were
R9137 T12140 T12144 arg1Of and,present
R9138 T12141 T12140 arg2Of IκBα,and
R9139 T12142 T12143 arg1Of were,still
R9140 T12144 T12142 arg2Of present,were
R9141 T12144 T12145 arg1Of present,at
R9142 T12147 T12145 arg2Of μM,at
R9143 T12147 T12146 arg1Of μM,25
R9144 T12149 T12148 arg1Of findings,These
R9145 T12149 T12150 arg1Of findings,suggest
R9146 T12152 T12154 arg1Of triciribine,targets
R9147 T12154 T12151 arg1Of targets,that
R9148 T12154 T12153 arg1Of targets,specifically
R9149 T12154 T12156 arg1Of targets,and
R9150 T12155 T12154 arg2Of Akt,targets
R9151 T12156 T12150 arg2Of and,suggest
R9152 T12157 T12156 arg2Of that,and
R9153 T12159 T12158 arg1Of activation,Akt
R9154 T12159 T12160 arg1Of activation,is
R9155 T12159 T12161 arg2Of activation,required
R9156 T12161 T12157 arg2Of required,that
R9157 T12161 T12160 arg2Of required,is
R9158 T12161 T12162 arg1Of required,for
R9159 T12165 T12162 arg2Of viability,for
R9160 T12165 T12163 arg1Of viability,the
R9161 T12165 T12164 arg2Of viability,enhanced
R9162 T12165 T12166 arg1Of viability,of
R9163 T12169 T12168 arg1Of lymphocytes,transgenic
R9164 T12169 T12170 arg1Of lymphocytes,and
R9165 T12170 T12166 arg2Of and,of
R9166 T12170 T12167 arg1Of and,the
R9167 T12172 T12170 arg2Of cells,and
R9168 T12172 T12171 arg1Of cells,lymphoma
R9169 T12173 T12174 arg1Of Inhibition,of
R9170 T12173 T12178 arg1Of Inhibition,induces
R9171 T12176 T12174 arg2Of signaling,of
R9172 T12176 T12175 arg1Of signaling,NFκB
R9173 T12178 T12177 arg1Of induces,rapidly
R9174 T12178 T12184 arg1Of induces,[
R9175 T12180 T12178 arg2Of death,induces
R9176 T12180 T12179 arg1Of death,cell
R9177 T12180 T12181 arg1Of death,of
R9178 T12183 T12181 arg2Of lymphocytes,of
R9179 T12183 T12182 arg1Of lymphocytes,EBV-transformed
R9180 T12185 T12184 arg2Of "17,18",[
R9181 T12186 T12184 arg3Of ],[
R9182 T12187 T12188 arg1Of BAY11–7085,","
R9183 T12187 T12197 arg1Of BAY11–7085,decreased
R9184 T12190 T12188 arg2Of inhibitor,","
R9185 T12190 T12189 arg1Of inhibitor,an
R9186 T12190 T12191 arg1Of inhibitor,of
R9187 T12193 T12191 arg2Of signaling,of
R9188 T12193 T12192 arg1Of signaling,NFκB
R9189 T12197 T12194 arg1Of decreased,","
R9190 T12197 T12195 arg1Of decreased,also
R9191 T12197 T12196 arg1Of decreased,greatly
R9192 T12197 T12216 arg1Of decreased,and
R9193 T12199 T12197 arg2Of viability,decreased
R9194 T12199 T12198 arg1Of viability,the
R9195 T12199 T12200 arg1Of viability,of
R9196 T12199 T12208 arg1Of viability,at
R9197 T12204 T12202 arg1Of lymphocytes,LMP1
R9198 T12204 T12203 arg1Of lymphocytes,transgenic
R9199 T12204 T12205 arg1Of lymphocytes,and
R9200 T12205 T12200 arg2Of and,of
R9201 T12205 T12201 arg1Of and,the
R9202 T12207 T12205 arg2Of cells,and
R9203 T12207 T12206 arg1Of cells,lymphoma
R9204 T12213 T12210 arg1Of 1,as
R9205 T12213 T12211 arg1Of 1,low
R9206 T12213 T12212 arg1Of 1,as
R9207 T12214 T12208 arg2Of μM,at
R9208 T12214 T12209 arg1Of μM,doses
R9209 T12214 T12213 arg1Of μM,1
R9210 T12216 T12215 arg1Of and,","
R9211 T12219 T12217 arg2Of μM,at
R9212 T12219 T12218 arg1Of μM,5
R9213 T12221 T12220 arg1Of cells,the
R9214 T12221 T12222 arg1Of cells,were
R9215 T12221 T12224 arg1Of cells,nonviable
R9216 T12222 T12216 arg2Of were,and
R9217 T12222 T12217 arg1Of were,at
R9218 T12224 T12222 arg2Of nonviable,were
R9219 T12224 T12223 arg1Of nonviable,completely
R9220 T12224 T12225 arg1Of nonviable,(
R9221 T12226 T12225 arg2Of Figure,(
R9222 T12226 T12227 arg1Of Figure,7
R9223 T12228 T12225 arg3Of ),(
R9224 T12229 T12230 arg1Of This,is
R9225 T12229 T12232 arg1Of This,within
R9226 T12230 T12231 arg1Of is,well
R9227 T12232 T12230 arg2Of within,is
R9228 T12235 T12232 arg2Of IC50,within
R9229 T12235 T12233 arg1Of IC50,the
R9230 T12235 T12234 arg2Of IC50,reported
R9231 T12235 T12236 arg1Of IC50,of
R9232 T12238 T12236 arg2Of μM,of
R9233 T12238 T12237 arg1Of μM,10
R9234 T12240 T12241 arg1Of Akt,","
R9235 T12241 T12244 arg1Of ",",and
R9236 T12242 T12241 arg2Of Stat3,","
R9237 T12244 T12239 arg2Of and,Phosphorylated
R9238 T12244 T12243 arg1Of and,","
R9239 T12244 T12247 arg1Of and,were
R9240 T12244 T12249 arg1Of and,present
R9241 T12244 T12258 arg1Of and,were
R9242 T12244 T12261 arg2Of and,detected
R9243 T12246 T12244 arg2Of IκBα,and
R9244 T12246 T12245 arg1Of IκBα,total
R9245 T12247 T12248 arg1Of were,still
R9246 T12247 T12256 arg1Of were,and
R9247 T12249 T12247 arg2Of present,were
R9248 T12249 T12251 arg1Of present,to
R9249 T12251 T12250 arg1Of to,up
R9250 T12252 T12251 arg2Of treatment,to
R9251 T12252 T12253 arg1Of treatment,with
R9252 T12255 T12253 arg2Of μM,with
R9253 T12255 T12254 arg1Of μM,15
R9254 T12260 T12259 arg1Of longer,no
R9255 T12261 T12256 arg2Of detected,and
R9256 T12261 T12257 arg1Of detected,then
R9257 T12261 T12258 arg2Of detected,were
R9258 T12261 T12260 arg1Of detected,longer
R9259 T12261 T12262 arg1Of detected,(
R9260 T12263 T12262 arg2Of Figure,(
R9261 T12263 T12264 arg1Of Figure,8
R9262 T12265 T12262 arg3Of ),(
R9263 T12267 T12266 arg1Of finding,This
R9264 T12267 T12268 arg1Of finding,suggests
R9265 T12270 T12271 arg1Of inhibition,of
R9266 T12270 T12273 arg1Of inhibition,can
R9267 T12270 T12274 arg1Of inhibition,induce
R9268 T12272 T12271 arg2Of NFκB,of
R9269 T12274 T12268 arg2Of induce,suggests
R9270 T12274 T12269 arg1Of induce,that
R9271 T12274 T12273 arg2Of induce,can
R9272 T12274 T12284 arg1Of induce,without
R9273 T12274 T12287 arg1Of induce,on
R9274 T12276 T12274 arg2Of death,induce
R9275 T12276 T12275 arg1Of death,cell
R9276 T12276 T12277 arg1Of death,in
R9277 T12280 T12278 arg1Of lymphocytes,LMP1
R9278 T12280 T12279 arg1Of lymphocytes,transgenic
R9279 T12280 T12281 arg1Of lymphocytes,and
R9280 T12281 T12277 arg2Of and,in
R9281 T12283 T12281 arg2Of cells,and
R9282 T12283 T12282 arg1Of cells,lymphoma
R9283 T12286 T12284 arg2Of effects,without
R9284 T12286 T12285 arg1Of effects,significant
R9285 T12288 T12287 arg2Of activation,on
R9286 T12288 T12289 arg1Of activation,of
R9287 T12290 T12291 arg1Of Akt,or
R9288 T12291 T12289 arg2Of or,of
R9289 T12292 T12291 arg2Of Stat3,or
R9290 T12294 T12293 arg1Of I,Cucurbitacin
R9291 T12294 T12295 arg1Of I,inhibits
R9292 T12294 T12300 arg1Of I,suppressing
R9293 T12295 T12299 arg1Of inhibits,by
R9294 T12296 T12295 arg2Of activation,inhibits
R9295 T12296 T12297 arg1Of activation,of
R9296 T12298 T12297 arg2Of Stat3,of
R9297 T12300 T12299 arg2Of suppressing,by
R9298 T12302 T12300 arg2Of activation,suppressing
R9299 T12302 T12301 arg1Of activation,the
R9300 T12302 T12303 arg1Of activation,of
R9301 T12306 T12303 arg2Of JAK2,of
R9302 T12306 T12304 arg1Of JAK2,its
R9303 T12306 T12305 arg1Of JAK2,kinase
R9304 T12307 T12308 arg1Of It,has
R9305 T12307 T12309 arg1Of It,been
R9306 T12307 T12310 arg2Of It,shown
R9307 T12307 T12313 arg1Of It,inhibit
R9308 T12310 T12308 arg2Of shown,has
R9309 T12310 T12309 arg2Of shown,been
R9310 T12313 T12310 arg3Of inhibit,shown
R9311 T12313 T12311 arg1Of inhibit,to
R9312 T12313 T12312 arg1Of inhibit,selectively
R9313 T12315 T12313 arg2Of growth,inhibit
R9314 T12315 T12314 arg1Of growth,the
R9315 T12315 T12316 arg1Of growth,of
R9316 T12317 T12316 arg2Of tumors,of
R9317 T12317 T12318 arg1Of tumors,with
R9318 T12320 T12319 arg1Of activated,constitutively
R9319 T12321 T12318 arg2Of Stat3,with
R9320 T12321 T12320 arg1Of Stat3,activated
R9321 T12321 T12322 arg1Of Stat3,[
R9322 T12323 T12322 arg2Of 47,[
R9323 T12324 T12322 arg3Of ],[
R9324 T12329 T12327 arg1Of lymphocytes,LMP1
R9325 T12329 T12328 arg1Of lymphocytes,transgenic
R9326 T12329 T12330 arg1Of lymphocytes,and
R9327 T12330 T12333 arg1Of and,were
R9328 T12330 T12334 arg1Of and,susceptible
R9329 T12332 T12330 arg2Of cells,and
R9330 T12332 T12331 arg1Of cells,lymphoma
R9331 T12333 T12325 arg1Of were,Similarly
R9332 T12333 T12326 arg1Of were,","
R9333 T12334 T12333 arg2Of susceptible,were
R9334 T12334 T12335 arg1Of susceptible,to
R9335 T12338 T12335 arg2Of treatment,to
R9336 T12338 T12336 arg1Of treatment,cucurbitacin
R9337 T12338 T12337 arg1Of treatment,I
R9338 T12338 T12339 arg1Of treatment,starting
R9339 T12338 T12343 arg1Of treatment,","
R9340 T12339 T12340 arg1Of starting,at
R9341 T12342 T12340 arg2Of μM,at
R9342 T12342 T12341 arg1Of μM,0.1
R9343 T12345 T12343 arg2Of dose,","
R9344 T12345 T12344 arg1Of dose,a
R9345 T12345 T12346 arg1Of dose,that
R9346 T12345 T12347 arg1Of dose,corresponds
R9347 T12347 T12348 arg1Of corresponds,closely
R9348 T12347 T12349 arg1Of corresponds,to
R9349 T12352 T12349 arg2Of IC50,to
R9350 T12352 T12350 arg1Of IC50,the
R9351 T12352 T12351 arg2Of IC50,reported
R9352 T12352 T12353 arg1Of IC50,of
R9353 T12355 T12353 arg2Of nM,of
R9354 T12355 T12354 arg1Of nM,500
R9355 T12355 T12356 arg1Of nM,(
R9356 T12355 T12360 arg1Of nM,[
R9357 T12357 T12356 arg2Of Figure,(
R9358 T12357 T12358 arg1Of Figure,7
R9359 T12359 T12356 arg3Of ),(
R9360 T12361 T12360 arg2Of 47,[
R9361 T12362 T12360 arg3Of ],[
R9362 T12364 T12365 arg1Of Akt,","
R9363 T12365 T12368 arg1Of ",",and
R9364 T12366 T12365 arg2Of Stat3,","
R9365 T12368 T12363 arg2Of and,Phosphorylated
R9366 T12368 T12367 arg1Of and,","
R9367 T12368 T12371 arg1Of and,were
R9368 T12368 T12373 arg1Of and,detectable
R9369 T12370 T12368 arg2Of IκBα,and
R9370 T12370 T12369 arg1Of IκBα,total
R9371 T12371 T12372 arg1Of were,not
R9372 T12371 T12374 arg1Of were,past
R9373 T12371 T12377 arg1Of were,and
R9374 T12373 T12371 arg2Of detectable,were
R9375 T12376 T12374 arg2Of μM,past
R9376 T12376 T12375 arg1Of μM,1
R9377 T12380 T12378 arg2Of doses,at
R9378 T12380 T12379 arg1Of doses,higher
R9379 T12383 T12381 arg1Of levels,all
R9380 T12383 T12382 arg1Of levels,protein
R9381 T12383 T12384 arg1Of levels,were
R9382 T12383 T12386 arg2Of levels,decreased
R9383 T12386 T12377 arg2Of decreased,and
R9384 T12386 T12378 arg1Of decreased,at
R9385 T12386 T12384 arg2Of decreased,were
R9386 T12386 T12385 arg1Of decreased,greatly
R9387 T12386 T12387 arg1Of decreased,","
R9388 T12386 T12388 arg1Of decreased,indicative
R9389 T12388 T12389 arg1Of indicative,of
R9390 T12392 T12389 arg2Of loss,of
R9391 T12392 T12390 arg1Of loss,the
R9392 T12392 T12391 arg1Of loss,total
R9393 T12392 T12393 arg1Of loss,of
R11228 T14963 T14962 arg1Of lack,this
R11229 T14963 T14964 arg1Of lack,of
R11230 T14965 T14964 arg2Of effect,of
R11231 T14968 T14967 arg1Of differentiation,the
R11232 T14968 T14969 arg1Of differentiation,of
R11233 T14968 T14971 arg1Of differentiation,versus
R11234 T14968 T14974 arg1Of differentiation,is
R11235 T14968 T14975 arg2Of differentiation,thought
R11236 T14968 T14977 arg1Of differentiation,be
R11237 T14968 T14978 arg1Of differentiation,independent
R11238 T14970 T14969 arg2Of B-1,of
R11239 T14973 T14971 arg2Of cells,versus
R11240 T14973 T14972 arg1Of cells,B-2
R11241 T14975 T14959 arg1Of thought,In
R11242 T14975 T14966 arg1Of thought,","
R11243 T14975 T14974 arg2Of thought,is
R11244 T14977 T14975 arg3Of be,thought
R11245 T14977 T14976 arg1Of be,to
R11246 T14977 T14982 arg1Of be,[
R11247 T14978 T14977 arg2Of independent,be
R11248 T14978 T14979 arg1Of independent,of
R11249 T14981 T14979 arg2Of signaling,of
R11250 T14981 T14980 arg1Of signaling,CD40
R11251 T14983 T14982 arg2Of 54,[
R11252 T14984 T14982 arg3Of ],[
R11253 T14986 T14985 arg1Of cells,B-1
R11254 T14986 T14987 arg1Of cells,constitute
R11255 T14987 T14992 arg1Of constitute,in
R11256 T14987 T14998 arg1Of constitute,","
R11257 T14987 T14999 arg1Of constitute,while
R11258 T14991 T14987 arg2Of population,constitute
R11259 T14991 T14988 arg1Of population,the
R11260 T14991 T14989 arg1Of population,predominant
R11261 T14991 T14990 arg1Of population,lymphocyte
R11262 T14994 T14995 arg1Of peritoneal,and
R11263 T14996 T14995 arg2Of pleuropericardial,and
R11264 T14997 T14992 arg2Of cavities,in
R11265 T14997 T14993 arg1Of cavities,the
R11266 T14997 T14994 arg1Of cavities,peritoneal
R11267 T14997 T14996 arg1Of cavities,pleuropericardial
R11268 T15001 T15000 arg1Of cells,B-2
R11269 T15001 T15002 arg1Of cells,are
R11270 T15001 T15004 arg2Of cells,found
R11271 T15004 T14999 arg2Of found,while
R11272 T15004 T15002 arg2Of found,are
R11273 T15004 T15003 arg1Of found,mainly
R11274 T15004 T15005 arg1Of found,in
R11275 T15007 T15008 arg1Of spleen,","
R11276 T15009 T15008 arg2Of lymph,","
R11277 T15010 T15007 arg1Of node,spleen
R11278 T15010 T15009 arg1Of node,lymph
R11279 T15010 T15012 arg1Of node,and
R11280 T15012 T15005 arg2Of and,in
R11281 T15012 T15006 arg1Of and,the
R11282 T15012 T15011 arg1Of and,","
R11283 T15014 T15012 arg2Of blood,and
R11284 T15014 T15013 arg1Of blood,peripheral
R11285 T15016 T15015 arg1Of cells,B-1
R11286 T15016 T15017 arg1Of cells,produce
R11287 T15020 T15017 arg2Of source,produce
R11288 T15020 T15018 arg1Of source,the
R11289 T15020 T15019 arg1Of source,main
R11290 T15020 T15021 arg1Of source,of
R11291 T15020 T15026 arg1Of source,in
R11292 T15022 T15023 arg1Of IgM,and
R11293 T15024 T15023 arg2Of IgA,and
R11294 T15025 T15021 arg2Of antibodies,of
R11295 T15025 T15022 arg1Of antibodies,IgM
R11296 T15025 T15024 arg1Of antibodies,IgA
R11297 T15027 T15026 arg2Of serum,in
R11298 T15027 T15028 arg1Of serum,","
R11299 T15027 T15029 arg1Of serum,which
R11300 T15027 T15030 arg1Of serum,are
R11301 T15027 T15031 arg2Of serum,involved
R11302 T15031 T15030 arg2Of involved,are
R11303 T15031 T15032 arg1Of involved,in
R11304 T15035 T15032 arg2Of responses,in
R11305 T15035 T15033 arg1Of responses,T
R11306 T15035 T15034 arg1Of responses,cell–independent
R11307 T15035 T15036 arg1Of responses,to
R11308 T15039 T15036 arg2Of antigens,to
R11309 T15039 T15037 arg1Of antigens,common
R11310 T15039 T15038 arg1Of antigens,microbial
R11311 T15043 T15042 arg1Of cells,B-1
R11312 T15043 T15044 arg1Of cells,have
R11313 T15043 T15052 arg1Of cells,are
R11314 T15043 T15054 arg2Of cells,predisposed
R11315 T15044 T15048 arg1Of have,to
R11316 T15044 T15051 arg1Of have,and
R11317 T15047 T15044 arg2Of capacity,have
R11318 T15047 T15045 arg1Of capacity,the
R11319 T15047 T15046 arg1Of capacity,unique
R11320 T15047 T15050 arg1Of capacity,replenish
R11321 T15049 T15048 arg2Of self,to
R11322 T15050 T15044 arg3Of replenish,have
R11323 T15051 T15040 arg1Of and,Importantly
R11324 T15051 T15041 arg1Of and,","
R11325 T15054 T15051 arg2Of predisposed,and
R11326 T15054 T15052 arg2Of predisposed,are
R11327 T15054 T15053 arg1Of predisposed,also
R11328 T15054 T15055 arg1Of predisposed,to
R11329 T15056 T15055 arg2Of transformation,to
R11330 T15056 T15057 arg1Of transformation,[
R11331 T15058 T15057 arg2Of "28,29",[
R11332 T15059 T15057 arg3Of ],[
R11333 T15061 T15060 arg1Of expansion,Clonal
R11334 T15061 T15062 arg1Of expansion,of
R11335 T15061 T15065 arg1Of expansion,can
R11336 T15061 T15066 arg1Of expansion,be
R11337 T15061 T15067 arg2Of expansion,detected
R11338 T15064 T15062 arg2Of cells,of
R11339 T15064 T15063 arg1Of cells,B-1
R11340 T15067 T15065 arg2Of detected,can
R11341 T15067 T15066 arg2Of detected,be
R11342 T15067 T15068 arg1Of detected,in
R11343 T15067 T15077 arg1Of detected,and
R11344 T15070 T15068 arg2Of mice,in
R11345 T15070 T15069 arg1Of mice,aging
R11346 T15070 T15071 arg1Of mice,above
R11347 T15073 T15071 arg2Of mo,above
R11348 T15073 T15072 arg1Of mo,18
R11349 T15073 T15074 arg1Of mo,of
R11350 T15075 T15074 arg2Of age,of
R11351 T15077 T15076 arg1Of and,","
R11352 T15079 T15078 arg1Of cells,B-1
R11353 T15079 T15080 arg1Of cells,are
R11354 T15079 T15081 arg2Of cells,thought
R11355 T15079 T15083 arg1Of cells,be
R11356 T15081 T15077 arg2Of thought,and
R11357 T15081 T15080 arg2Of thought,are
R11358 T15083 T15081 arg3Of be,thought
R11359 T15083 T15082 arg1Of be,to
R11360 T15086 T15083 arg2Of progenitor,be
R11361 T15086 T15084 arg1Of progenitor,the
R11362 T15086 T15085 arg1Of progenitor,murine
R11363 T15086 T15087 arg1Of progenitor,of
R11364 T15092 T15087 arg2Of leukemia,of
R11365 T15092 T15088 arg1Of leukemia,B
R11366 T15092 T15089 arg1Of leukemia,cell
R11367 T15092 T15090 arg1Of leukemia,chronic
R11368 T15092 T15091 arg1Of leukemia,lymphocytic
R11369 T15092 T15093 arg1Of leukemia,[
R11370 T15094 T15093 arg2Of 30,[
R11371 T15095 T15093 arg3Of ],[
R11372 T15097 T15096 arg1Of data,The
R11373 T15097 T15098 arg2Of data,presented
R11374 T15097 T15102 arg1Of data,indicate
R11375 T15098 T15099 arg1Of presented,in
R11376 T15101 T15099 arg2Of study,in
R11377 T15101 T15100 arg1Of study,this
R11378 T15105 T15106 arg1Of LMP1,is
R11379 T15105 T15107 arg2Of LMP1,expressed
R11380 T15107 T15104 arg2Of expressed,although
R11381 T15107 T15106 arg2Of expressed,is
R11382 T15107 T15108 arg1Of expressed,in
R11383 T15111 T15108 arg2Of lymphocytes,in
R11384 T15111 T15109 arg1Of lymphocytes,all
R11385 T15111 T15110 arg1Of lymphocytes,B
R11386 T15111 T15112 arg1Of lymphocytes,in
R11387 T15115 T15112 arg2Of mice,in
R11388 T15115 T15113 arg1Of mice,the
R11389 T15115 T15114 arg1Of mice,transgenic
R11390 T15117 T15118 arg1Of malignancy,develops
R11391 T15118 T15102 arg2Of develops,indicate
R11392 T15118 T15103 arg1Of develops,that
R11393 T15118 T15104 arg1Of develops,although
R11394 T15118 T15116 arg1Of develops,","
R11395 T15118 T15119 arg1Of develops,in
R11396 T15122 T15119 arg2Of subset,in
R11397 T15122 T15120 arg1Of subset,this
R11398 T15122 T15121 arg1Of subset,specific
R11399 T15122 T15123 arg1Of subset,of
R11400 T15125 T15123 arg2Of cells,of
R11401 T15125 T15124 arg1Of cells,B
R11402 T15128 T15126 arg1Of expression,The
R11403 T15128 T15127 arg2Of expression,elevated
R11404 T15128 T15129 arg1Of expression,of
R11405 T15128 T15131 arg1Of expression,in
R11406 T15128 T15134 arg1Of expression,and
R11407 T15130 T15129 arg2Of LMP1,of
R11408 T15133 T15131 arg2Of cells,in
R11409 T15133 T15132 arg1Of cells,B-1a
R11410 T15134 T15141 arg1Of and,induce
R11411 T15136 T15134 arg2Of activation,and
R11412 T15136 T15135 arg1Of activation,the
R11413 T15136 T15137 arg1Of activation,of
R11414 T15139 T15137 arg2Of pathways,of
R11415 T15139 T15138 arg1Of pathways,specific
R11416 T15141 T15140 arg1Of induce,apparently
R11417 T15143 T15141 arg2Of growth,induce
R11418 T15143 T15142 arg1Of growth,malignant
R11419 T15146 T15144 arg1Of pathways,These
R11420 T15146 T15145 arg1Of pathways,same
R11421 T15146 T15147 arg1Of pathways,can
R11422 T15146 T15149 arg1Of pathways,become
R11423 T15146 T15151 arg2Of pathways,activated
R11424 T15146 T15157 arg1Of pathways,result
R11425 T15151 T15147 arg2Of activated,can
R11426 T15151 T15148 arg1Of activated,also
R11427 T15151 T15149 arg2Of activated,become
R11428 T15151 T15150 arg1Of activated,sporadically
R11429 T15151 T15152 arg1Of activated,in
R11430 T15151 T15155 arg1Of activated,and
R11431 T15154 T15152 arg2Of mice,in
R11432 T15154 T15153 arg1Of mice,aged
R11433 T15157 T15155 arg2Of result,and
R11434 T15157 T15156 arg1Of result,also
R11435 T15157 T15158 arg1Of result,in
R11436 T15160 T15158 arg2Of development,in
R11437 T15160 T15159 arg1Of development,lymphoma
R11438 T15161 T15162 arg1Of This,is
R11439 T15161 T15163 arg1Of This,similar
R11440 T15163 T15162 arg2Of similar,is
R11441 T15163 T15164 arg1Of similar,to
R11442 T15166 T15164 arg2Of cancers,to
R11443 T15166 T15165 arg1Of cancers,EBV-associated
R11444 T15166 T15168 arg1Of cancers,vivo
R11445 T15166 T15169 arg1Of cancers,","
R11446 T15166 T15170 arg1Of cancers,where
R11447 T15168 T15167 arg1Of vivo,in
R11448 T15171 T15172 arg1Of pathways,that
R11449 T15171 T15173 arg1Of pathways,are
R11450 T15171 T15174 arg2Of pathways,activated
R11451 T15171 T15177 arg1Of pathways,are
R11452 T15171 T15179 arg2Of pathways,activated
R11453 T15174 T15173 arg2Of activated,are
R11454 T15176 T15174 arg1Of LMP1,activated
R11455 T15176 T15175 arg2Of LMP1,by
R11456 T15179 T15170 arg2Of activated,where
R11457 T15179 T15177 arg2Of activated,are
R11458 T15179 T15178 arg1Of activated,also
R11459 T15179 T15180 arg1Of activated,in
R11460 T15183 T15182 arg1Of prevalent,less
R11461 T15185 T15180 arg2Of forms,in
R11462 T15185 T15181 arg1Of forms,the
R11463 T15185 T15183 arg1Of forms,prevalent
R11464 T15185 T15184 arg1Of forms,EBV-negative
R11465 T15185 T15186 arg1Of forms,of
R11466 T15188 T15186 arg2Of cancers,of
R11467 T15188 T15187 arg1Of cancers,the
R11468 T15188 T15189 arg1Of cancers,[
R11469 T15190 T15189 arg2Of "40,55–58",[
R11470 T15191 T15189 arg3Of ],[
R11471 T15195 T15194 arg1Of contribution,the
R11472 T15195 T15196 arg1Of contribution,of
R11473 T15195 T15200 arg1Of contribution,to
R11474 T15195 T15203 arg1Of contribution,is
R11475 T15197 T15198 arg1Of EBV,and
R11476 T15198 T15196 arg2Of and,of
R11477 T15199 T15198 arg2Of LMP1,and
R11478 T15202 T15200 arg2Of development,to
R11479 T15202 T15201 arg1Of development,tumor
R11480 T15203 T15192 arg1Of is,Thus
R11481 T15203 T15193 arg1Of is,","
R11482 T15203 T15204 arg1Of is,apparently
R11483 T15207 T15203 arg2Of activation,is
R11484 T15207 T15205 arg1Of activation,the
R11485 T15207 T15206 arg1Of activation,continuous
R11486 T15207 T15208 arg1Of activation,of
R11487 T15209 T15208 arg2Of pathways,of
R11488 T15209 T15210 arg1Of pathways,that
R11489 T15209 T15211 arg1Of pathways,can
R11490 T15209 T15213 arg1Of pathways,be
R11491 T15209 T15215 arg2Of pathways,activated
R11492 T15209 T15217 arg1Of pathways,contribute
R11493 T15215 T15211 arg2Of activated,can
R11494 T15215 T15212 arg1Of activated,also
R11495 T15215 T15213 arg2Of activated,be
R11496 T15215 T15214 arg1Of activated,sporadically
R11497 T15215 T15216 arg1Of activated,and
R11498 T15217 T15216 arg2Of contribute,and
R11499 T15217 T15218 arg1Of contribute,to
R11500 T15220 T15218 arg2Of development,to
R11501 T15220 T15219 arg1Of development,tumor
R11502 T15222 T15221 arg1Of lymphomas,The
R11503 T15222 T15223 arg1Of lymphomas,were
R11504 T15222 T15224 arg2Of lymphomas,marked
R11505 T15224 T15223 arg2Of marked,were
R11506 T15227 T15224 arg1Of upregulation,marked
R11507 T15227 T15225 arg2Of upregulation,by
R11508 T15227 T15226 arg1Of upregulation,the
R11509 T15227 T15228 arg1Of upregulation,of
R11510 T15229 T15230 arg1Of IL10,","
R11511 T15229 T15237 arg1Of IL10,and
R11512 T15232 T15230 arg2Of activation,","
R11513 T15232 T15231 arg1Of activation,constitutive
R11514 T15232 T15233 arg1Of activation,of
R11515 T15235 T15233 arg2Of signaling,of
R11516 T15235 T15234 arg1Of signaling,Stat3
R11517 T15237 T15228 arg2Of and,of
R11518 T15237 T15236 arg1Of and,","
R11519 T15239 T15237 arg2Of requirement,and
R11520 T15239 T15238 arg1Of requirement,a
R11521 T15239 T15240 arg1Of requirement,for
R11522 T15241 T15240 arg2Of activation,for
R11523 T15241 T15242 arg1Of activation,of
R11524 T15243 T15244 arg1Of Akt,","
R11525 T15244 T15247 arg1Of ",",and
R11526 T15245 T15244 arg2Of NFκB,","
R11527 T15247 T15242 arg2Of and,of
R11528 T15247 T15246 arg1Of and,","
R11529 T15249 T15247 arg2Of pathways,and
R11530 T15249 T15248 arg1Of pathways,Stat3
R11531 T15249 T15250 arg1Of pathways,(
R11532 T15252 T15253 arg1Of 5,and
R11533 T15253 T15250 arg2Of and,(
R11534 T15253 T15251 arg1Of and,Figures
R11535 T15254 T15253 arg2Of 7,and
R11536 T15255 T15250 arg3Of ),(
R11537 T15256 T15257 arg1Of Induction,of
R11538 T15256 T15259 arg1Of Induction,is
R11539 T15256 T15260 arg2Of Induction,associated
R11540 T15256 T15273 arg1Of Induction,is
R11541 T15256 T15275 arg2Of Induction,associated
R11542 T15258 T15257 arg2Of IL10,of
R11543 T15260 T15259 arg2Of associated,is
R11544 T15260 T15261 arg1Of associated,with
R11545 T15260 T15269 arg1Of associated,[
R11546 T15260 T15272 arg1Of associated,and
R11547 T15263 T15261 arg2Of transformation,with
R11548 T15263 T15262 arg1Of transformation,the
R11549 T15263 T15264 arg1Of transformation,of
R11550 T15263 T15267 arg1Of transformation,in
R11551 T15266 T15264 arg2Of lymphomas,of
R11552 T15266 T15265 arg1Of lymphomas,B-1
R11553 T15268 T15267 arg2Of mice,in
R11554 T15270 T15269 arg2Of "59,60",[
R11555 T15271 T15269 arg3Of ],[
R11556 T15275 T15272 arg2Of associated,and
R11557 T15275 T15273 arg2Of associated,is
R11558 T15275 T15274 arg1Of associated,frequently
R11559 T15275 T15276 arg1Of associated,with
R11560 T15280 T15276 arg2Of malignancies,with
R11561 T15280 T15277 arg1Of malignancies,EBV-positive
R11562 T15280 T15278 arg1Of malignancies,B
R11563 T15280 T15279 arg1Of malignancies,cell
R11564 T15280 T15281 arg1Of malignancies,acting
R11565 T15281 T15282 arg1Of acting,as
R11566 T15287 T15282 arg2Of factor,as
R11567 T15287 T15283 arg1Of factor,a
R11568 T15287 T15284 arg1Of factor,B
R11569 T15287 T15285 arg1Of factor,cell
R11570 T15287 T15286 arg1Of factor,growth
R11571 T15287 T15288 arg1Of factor,[
R11572 T15289 T15288 arg2Of 35–38,[
R11573 T15290 T15288 arg3Of ],[
R11574 T15292 T15291 arg2Of addition,In
R11575 T15294 T15295 arg1Of LMP1,has
R11576 T15294 T15296 arg1Of LMP1,been
R11577 T15294 T15297 arg2Of LMP1,shown
R11578 T15294 T15299 arg1Of LMP1,stimulate
R11579 T15297 T15291 arg1Of shown,In
R11580 T15297 T15293 arg1Of shown,","
R11581 T15297 T15295 arg2Of shown,has
R11582 T15297 T15296 arg2Of shown,been
R11583 T15299 T15297 arg3Of stimulate,shown
R11584 T15299 T15298 arg1Of stimulate,to
R11585 T15299 T15302 arg1Of stimulate,in
R11586 T15301 T15299 arg2Of expression,stimulate
R11587 T15301 T15300 arg1Of expression,IL10
R11588 T15306 T15302 arg2Of lines,in
R11589 T15306 T15303 arg1Of lines,Burkitt
R11590 T15306 T15304 arg1Of lines,lymphoma
R11591 T15306 T15305 arg1Of lines,cell
R11592 T15306 T15307 arg1Of lines,[
R11593 T15308 T15307 arg2Of "61,62",[
R11594 T15309 T15307 arg3Of ],[
R11595 T15310 T15311 arg1Of This,suggests
R11596 T15314 T15315 arg1Of Stat3,is
R11597 T15314 T15317 arg2Of Stat3,activated
R11598 T15317 T15313 arg2Of activated,although
R11599 T15317 T15315 arg2Of activated,is
R11600 T15317 T15316 arg1Of activated,constitutively
R11601 T15317 T15318 arg1Of activated,in
R11602 T15321 T15318 arg2Of cells,in
R11603 T15321 T15319 arg1Of cells,the
R11604 T15321 T15320 arg1Of cells,lymphoma
R11605 T15324 T15323 arg1Of induction,the
R11606 T15324 T15325 arg1Of induction,of
R11607 T15324 T15327 arg1Of induction,may
R11608 T15324 T15329 arg1Of induction,enhance
R11609 T15324 T15333 arg1Of induction,may
R11610 T15324 T15334 arg1Of induction,contribute
R11611 T15326 T15325 arg2Of IL10,of
R11612 T15329 T15327 arg2Of enhance,may
R11613 T15329 T15328 arg1Of enhance,further
R11614 T15329 T15332 arg1Of enhance,or
R11615 T15331 T15329 arg2Of activation,enhance
R11616 T15331 T15330 arg1Of activation,Stat3
R11617 T15332 T15311 arg2Of or,suggests
R11618 T15332 T15312 arg1Of or,that
R11619 T15332 T15313 arg1Of or,although
R11620 T15332 T15322 arg1Of or,","
R11621 T15334 T15332 arg2Of contribute,or
R11622 T15334 T15333 arg2Of contribute,may
R11623 T15334 T15335 arg1Of contribute,to
R11624 T15339 T15335 arg2Of pathways,to
R11625 T15339 T15336 arg1Of pathways,other
R11626 T15339 T15337 arg1Of pathways,IL10-responsive
R11627 T15339 T15338 arg1Of pathways,signaling
R11628 T15340 T15341 arg1Of LMP1,activates
R11629 T15341 T15355 arg1Of activates,and
R11630 T15344 T15345 arg1Of canonical,and
R11631 T15346 T15345 arg2Of non-canonical,and
R11632 T15347 T15341 arg2Of pathways,activates
R11633 T15347 T15342 arg1Of pathways,both
R11634 T15347 T15343 arg1Of pathways,the
R11635 T15347 T15344 arg1Of pathways,canonical
R11636 T15347 T15346 arg1Of pathways,non-canonical
R11637 T15347 T15348 arg1Of pathways,of
R11638 T15350 T15348 arg2Of signaling,of
R11639 T15350 T15349 arg1Of signaling,NFκB
R11640 T15350 T15351 arg1Of signaling,[
R11641 T15352 T15351 arg2Of "14,63–65",[
R11642 T15353 T15351 arg3Of ],[
R11643 T15355 T15354 arg1Of and,","
R11644 T15356 T15357 arg1Of inhibition,of
R11645 T15356 T15359 arg1Of inhibition,blocked
R11646 T15358 T15357 arg2Of NFκB,of
R11647 T15359 T15355 arg2Of blocked,and
R11648 T15361 T15359 arg2Of survival,blocked
R11649 T15361 T15360 arg1Of survival,the
R11650 T15361 T15362 arg1Of survival,of
R11651 T15365 T15363 arg1Of lymphocytes,LMP1
R11652 T15365 T15364 arg1Of lymphocytes,transgenic
R11653 T15365 T15366 arg1Of lymphocytes,and
R11654 T15366 T15362 arg2Of and,of
R11655 T15367 T15368 arg1Of LMP1-positive,and
R11656 T15369 T15368 arg2Of -negative,and
R11657 T15371 T15366 arg2Of cells,and
R11658 T15371 T15367 arg1Of cells,LMP1-positive
R11659 T15371 T15369 arg1Of cells,-negative
R11660 T15371 T15370 arg1Of cells,lymphoma
R11661 T15372 T15373 arg1Of NFκB,and
R11662 T15373 T15376 arg1Of and,are
R11663 T15373 T15377 arg1Of and,crucial
R11664 T15375 T15373 arg2Of signaling,and
R11665 T15375 T15374 arg1Of signaling,PI3K
R11666 T15376 T15382 arg1Of are,and
R11667 T15377 T15376 arg2Of crucial,are
R11668 T15377 T15378 arg1Of crucial,for
R11669 T15380 T15378 arg2Of proliferation,for
R11670 T15380 T15379 arg1Of proliferation,CD40-induced
R11671 T15382 T15381 arg1Of and,","
R11672 T15383 T15384 arg1Of mice,deficient
R11673 T15383 T15387 arg1Of mice,or
R11674 T15384 T15385 arg1Of deficient,for
R11675 T15386 T15385 arg2Of cRel,for
R11676 T15387 T15394 arg1Of or,are
R11677 T15387 T15395 arg1Of or,unresponsive
R11678 T15391 T15387 arg2Of subunit,or
R11679 T15391 T15388 arg1Of subunit,the
R11680 T15391 T15389 arg1Of subunit,p85
R11681 T15391 T15390 arg1Of subunit,regulatory
R11682 T15391 T15392 arg1Of subunit,of
R11683 T15393 T15392 arg2Of PI3K,of
R11684 T15394 T15382 arg2Of are,and
R11685 T15395 T15394 arg2Of unresponsive,are
R11686 T15395 T15396 arg1Of unresponsive,to
R11687 T15398 T15396 arg2Of stimuli,to
R11688 T15398 T15397 arg1Of stimuli,mitogenic
R11689 T15398 T15399 arg1Of stimuli,","
R11690 T15398 T15400 arg1Of stimuli,including
R11691 T15402 T15400 arg2Of ligation,including
R11692 T15402 T15401 arg1Of ligation,CD40
R11693 T15402 T15403 arg1Of ligation,[
R11694 T15404 T15403 arg2Of 66–68,[
R11695 T15405 T15403 arg3Of ],[
R11696 T15406 T15407 arg1Of We,have
R11697 T15406 T15409 arg1Of We,shown
R11698 T15409 T15407 arg2Of shown,have
R11699 T15409 T15408 arg1Of shown,previously
R11700 T15411 T15412 arg1Of cRel,is
R11701 T15411 T15414 arg2Of cRel,activated
R11702 T15414 T15409 arg2Of activated,shown
R11703 T15414 T15410 arg1Of activated,that
R11704 T15414 T15412 arg2Of activated,is
R11705 T15414 T15413 arg1Of activated,specifically
R11706 T15414 T15415 arg1Of activated,in
R11707 T15414 T15422 arg1Of activated,","
R11708 T15421 T15415 arg2Of lymphomas,in
R11709 T15421 T15416 arg1Of lymphomas,both
R11710 T15421 T15417 arg1Of lymphomas,wild-type
R11711 T15421 T15418 arg1Of lymphomas,and
R11712 T15421 T15419 arg1Of lymphomas,LMP1
R11713 T15421 T15420 arg1Of lymphomas,transgenic
R11714 T15423 T15414 arg3Of suggesting,activated
R11715 T15425 T15426 arg1Of activation,of
R11716 T15425 T15428 arg1Of activation,is
R11717 T15425 T15429 arg2Of activation,associated
R11718 T15427 T15426 arg2Of cRel,of
R11719 T15429 T15423 arg2Of associated,suggesting
R11720 T15429 T15424 arg1Of associated,that
R11721 T15429 T15428 arg2Of associated,is
R11722 T15429 T15430 arg1Of associated,with
R11723 T15429 T15434 arg1Of associated,[
R11724 T15433 T15430 arg2Of transformation,with
R11725 T15433 T15431 arg1Of transformation,B
R11726 T15433 T15432 arg1Of transformation,cell
R11727 T15435 T15434 arg2Of 27,[
R11728 T15436 T15434 arg3Of ],[
R11729 T15438 T15437 arg1Of observations,Our
R11730 T15438 T15439 arg1Of observations,suggest
R11731 T15444 T15442 arg2Of proliferation,to
R11732 T15444 T15443 arg1Of proliferation,CD40-induced
R11733 T15446 T15447 arg1Of LMP1,induces
R11734 T15447 T15439 arg2Of induces,suggest
R11735 T15447 T15440 arg1Of induces,that
R11736 T15447 T15441 arg1Of induces,similar
R11737 T15447 T15442 arg1Of induces,to
R11738 T15447 T15445 arg1Of induces,","
R11739 T15447 T15449 arg1Of induces,through
R11740 T15448 T15447 arg2Of proliferation,induces
R11741 T15451 T15450 arg1Of activation,PI3K-mediated
R11742 T15451 T15452 arg1Of activation,of
R11743 T15451 T15454 arg1Of activation,and
R11744 T15453 T15452 arg2Of Akt,of
R11745 T15454 T15449 arg2Of and,through
R11746 T15455 T15454 arg2Of activation,and
R11747 T15455 T15456 arg1Of activation,of
R11748 T15458 T15456 arg2Of components,of
R11749 T15458 T15457 arg1Of components,NFκB
R11750 T15458 T15460 arg1Of components,as
R11751 T15460 T15459 arg1Of as,such
R11752 T15461 T15460 arg2Of cRel,as
R11753 T15462 T15464 arg1Of CD40,induces
R11754 T15464 T15463 arg1Of induces,also
R11755 T15464 T15472 arg1Of induces,through
R11756 T15464 T15477 arg1Of induces,and
R11757 T15465 T15464 arg2Of downregulation,induces
R11758 T15465 T15466 arg1Of downregulation,of
R11759 T15471 T15466 arg2Of p27,of
R11760 T15471 T15467 arg1Of p27,the
R11761 T15471 T15468 arg1Of p27,cell
R11762 T15471 T15469 arg1Of p27,cycle
R11763 T15471 T15470 arg1Of p27,inhibitor
R11764 T15475 T15472 arg2Of manner,through
R11765 T15475 T15473 arg1Of manner,a
R11766 T15475 T15474 arg1Of manner,PI3K-dependent
R11767 T15477 T15476 arg1Of and,","
R11768 T15481 T15478 arg1Of cells,the
R11769 T15481 T15479 arg1Of cells,LMP1
R11770 T15481 T15480 arg1Of cells,lymphoma
R11771 T15481 T15483 arg1Of cells,had
R11772 T15481 T15484 arg1Of cells,decreased
R11773 T15484 T15477 arg2Of decreased,and
R11774 T15484 T15482 arg1Of decreased,also
R11775 T15484 T15483 arg2Of decreased,had
R11776 T15484 T15488 arg1Of decreased,with
R11777 T15484 T15499 arg1Of decreased,[
R11778 T15485 T15484 arg2Of levels,decreased
R11779 T15485 T15486 arg1Of levels,of
R11780 T15487 T15486 arg2Of p27,of
R11781 T15489 T15490 arg1Of phosphorylation,of
R11782 T15489 T15492 arg1Of phosphorylation,and
R11783 T15491 T15490 arg2Of Rb,of
R11784 T15492 T15488 arg2Of and,with
R11785 T15494 T15492 arg2Of Cdk2,and
R11786 T15494 T15493 arg2Of Cdk2,increased
R11787 T15494 T15495 arg1Of Cdk2,(
R11788 T15497 T15495 arg2Of 6C,(
R11789 T15497 T15496 arg1Of 6C,Figure
R11790 T15498 T15495 arg3Of ),(
R11791 T15500 T15499 arg2Of 66,[
R11792 T15501 T15499 arg3Of ],[
R11793 T15503 T15504 arg1Of LMP1,has
R11794 T15503 T15505 arg1Of LMP1,been
R11795 T15503 T15506 arg2Of LMP1,shown
R11796 T15503 T15508 arg1Of LMP1,deregulate
R11797 T15506 T15502 arg2Of shown,Although
R11798 T15506 T15504 arg2Of shown,has
R11799 T15506 T15505 arg2Of shown,been
R11800 T15506 T15518 arg1Of shown,","
R11801 T15506 T15519 arg1Of shown,to
R11802 T15508 T15506 arg3Of deregulate,shown
R11803 T15508 T15507 arg1Of deregulate,to
R11804 T15511 T15508 arg2Of pathway,deregulate
R11805 T15511 T15509 arg1Of pathway,the
R11806 T15511 T15510 arg1Of pathway,Rb
R11807 T15511 T15512 arg1Of pathway,in
R11808 T15514 T15512 arg2Of cells,in
R11809 T15514 T15513 arg1Of cells,epithelial
R11810 T15514 T15515 arg1Of cells,[
R11811 T15516 T15515 arg2Of 69,[
R11812 T15517 T15515 arg3Of ],[
R11813 T15521 T15519 arg2Of knowledge,to
R11814 T15521 T15520 arg1Of knowledge,our
R11815 T15522 T15523 arg1Of this,is
R11816 T15523 T15502 arg1Of is,Although
R11817 T15526 T15523 arg2Of demonstration,is
R11818 T15526 T15524 arg1Of demonstration,the
R11819 T15526 T15525 arg1Of demonstration,first
R11820 T15526 T15527 arg1Of demonstration,of
R11821 T15529 T15527 arg2Of property,of
R11822 T15529 T15528 arg1Of property,this
R11823 T15529 T15530 arg1Of property,in
R11824 T15532 T15530 arg2Of lymphocytes,in
R11825 T15532 T15531 arg1Of lymphocytes,B
R11826 T15534 T15533 arg1Of requirement,The
R11827 T15534 T15535 arg1Of requirement,for
R11828 T15534 T15538 arg1Of requirement,was
R11829 T15534 T15539 arg2Of requirement,confirmed
R11830 T15537 T15535 arg2Of activation,for
R11831 T15537 T15536 arg1Of activation,Akt
R11832 T15539 T15538 arg2Of confirmed,was
R11833 T15543 T15539 arg1Of inhibition,confirmed
R11834 T15543 T15540 arg2Of inhibition,by
R11835 T15543 T15541 arg1Of inhibition,the
R11836 T15543 T15542 arg1Of inhibition,striking
R11837 T15543 T15544 arg1Of inhibition,of
R11838 T15543 T15547 arg1Of inhibition,by
R11839 T15546 T15544 arg2Of viability,of
R11840 T15546 T15545 arg1Of viability,lymphoma
R11841 T15548 T15547 arg2Of triciribine,by
R11842 T15548 T15549 arg1Of triciribine,","
R11843 T15552 T15549 arg2Of inhibitor,","
R11844 T15552 T15550 arg1Of inhibitor,an
R11845 T15552 T15551 arg1Of inhibitor,Akt
R11846 T15557 T15555 arg1Of pAkt,the
R11847 T15557 T15556 arg2Of pAkt,activated
R11848 T15557 T15558 arg1Of pAkt,did
R11849 T15557 T15560 arg1Of pAkt,lead
R11850 T15560 T15553 arg1Of lead,However
R11851 T15560 T15554 arg1Of lead,","
R11852 T15560 T15558 arg2Of lead,did
R11853 T15560 T15559 arg1Of lead,not
R11854 T15560 T15561 arg1Of lead,to
R11855 T15562 T15563 arg1Of phosphorylation,and
R11856 T15563 T15561 arg2Of and,to
R11857 T15563 T15565 arg1Of and,of
R11858 T15564 T15563 arg2Of inactivation,and
R11859 T15569 T15565 arg2Of GSK3,of
R11860 T15569 T15566 arg1Of GSK3,the
R11861 T15569 T15567 arg1Of GSK3,downstream
R11862 T15569 T15568 arg1Of GSK3,target
R11863 T15569 T15570 arg1Of GSK3,(
R11864 T15572 T15570 arg2Of 6A,(
R11865 T15572 T15571 arg1Of 6A,Figure
R11866 T15573 T15570 arg3Of ),(
R11867 T15575 T15574 arg1Of effect,This
R11868 T15575 T15576 arg1Of effect,has
R11869 T15575 T15578 arg1Of effect,been
R11870 T15575 T15579 arg2Of effect,described
R11871 T15579 T15576 arg2Of described,has
R11872 T15579 T15577 arg1Of described,also
R11873 T15579 T15578 arg2Of described,been
R11874 T15579 T15580 arg1Of described,in
R11875 T15579 T15584 arg1Of described,[
R11876 T15583 T15580 arg2Of biopsies,in
R11877 T15583 T15581 arg1Of biopsies,EBV-positive
R11878 T15583 T15582 arg1Of biopsies,HD
R11879 T15585 T15584 arg2Of 40,[
R11880 T15586 T15584 arg3Of ],[
R11881 T15588 T15587 arg2Of contrast,In
R11882 T15590 T15591 arg1Of rapamycin,","
R11883 T15591 T15594 arg1Of ",",and
R11884 T15592 T15591 arg2Of U0126,","
R11885 T15594 T15593 arg1Of and,","
R11886 T15594 T15596 arg1Of and,did
R11887 T15594 T15598 arg1Of and,affect
R11888 T15595 T15594 arg2Of SB202190,and
R11889 T15598 T15587 arg1Of affect,In
R11890 T15598 T15589 arg1Of affect,","
R11891 T15598 T15596 arg2Of affect,did
R11892 T15598 T15597 arg1Of affect,not
R11893 T15600 T15599 arg1Of survival,the
R11894 T15600 T15601 arg1Of survival,of
R11895 T15600 T15605 arg1Of survival,or
R11896 T15604 T15601 arg2Of lymphocytes,of
R11897 T15604 T15602 arg1Of lymphocytes,LMP1
R11898 T15604 T15603 arg1Of lymphocytes,transgenic
R11899 T15605 T15598 arg2Of or,affect
R11900 T15607 T15608 arg1Of wild-type,and
R11901 T15608 T15605 arg2Of and,or
R11902 T15608 T15606 arg1Of and,the
R11903 T15608 T15613 arg1Of and,(
R11904 T15612 T15608 arg2Of cells,and
R11905 T15612 T15609 arg1Of cells,LMP1
R11906 T15612 T15610 arg1Of cells,transgenic
R11907 T15612 T15611 arg1Of cells,lymphoma
R11908 T15615 T15614 arg1Of 7A,Figure
R11909 T15615 T15616 arg1Of 7A,","
R11910 T15616 T15619 arg1Of ",",and
R11911 T15617 T15616 arg2Of 7C,","
R11912 T15619 T15613 arg2Of and,(
R11913 T15619 T15618 arg1Of and,","
R11914 T15620 T15619 arg2Of 7E,and
R11915 T15621 T15613 arg3Of ),(
R11916 T15623 T15622 arg1Of lack,This
R11917 T15623 T15624 arg1Of lack,of
R11918 T15623 T15628 arg1Of lack,confirmed
R11919 T15625 T15624 arg2Of effect,of
R11920 T15625 T15626 arg1Of effect,by
R11921 T15627 T15626 arg2Of rapamycin,by
R11922 T15630 T15628 arg2Of absence,confirmed
R11923 T15630 T15629 arg1Of absence,the
R11924 T15630 T15631 arg1Of absence,of
R11925 T15634 T15631 arg2Of levels,of
R11926 T15634 T15632 arg2Of levels,activated
R11927 T15634 T15633 arg1Of levels,p-mTOR
R11928 T15634 T15635 arg1Of levels,(
R11929 T15637 T15635 arg2Of 6B,(
R11930 T15637 T15636 arg1Of 6B,Figure
R11931 T15638 T15635 arg3Of ),(
R11932 T15640 T15639 arg1Of findings,These
R11933 T15640 T15641 arg1Of findings,suggest
R11934 T15645 T15643 arg1Of targets,other
R11935 T15645 T15644 arg1Of targets,Akt
R11936 T15645 T15646 arg1Of targets,contribute
R11937 T15646 T15641 arg2Of contribute,suggest
R11938 T15646 T15642 arg1Of contribute,that
R11939 T15646 T15647 arg1Of contribute,to
R11940 T15649 T15647 arg2Of progression,to
R11941 T15649 T15648 arg1Of progression,malignant
R11942 T15652 T15650 arg1Of target,One
R11943 T15652 T15651 arg1Of target,key
R11944 T15652 T15653 arg1Of target,is
R11945 T15653 T15654 arg1Of is,likely
R11946 T15656 T15653 arg2Of inhibition,is
R11947 T15656 T15655 arg1Of inhibition,the
R11948 T15656 T15657 arg1Of inhibition,of
R11949 T15661 T15657 arg2Of factors,of
R11950 T15661 T15658 arg1Of factors,the
R11951 T15661 T15659 arg1Of factors,Fox01
R11952 T15661 T15660 arg1Of factors,transcription
R11953 T15662 T15663 arg1Of Repression,of
R11954 T15662 T15673 arg1Of Repression,can
R11955 T15662 T15674 arg1Of Repression,inhibit
R11956 T15668 T15663 arg2Of FoxO1,of
R11957 T15668 T15664 arg1Of FoxO1,the
R11958 T15668 T15665 arg1Of FoxO1,pro-apoptotic
R11959 T15668 T15666 arg1Of FoxO1,transcription
R11960 T15668 T15667 arg1Of FoxO1,factor
R11961 T15668 T15669 arg1Of FoxO1,in
R11962 T15672 T15669 arg2Of manner,in
R11963 T15672 T15670 arg1Of manner,a
R11964 T15672 T15671 arg1Of manner,PI3K-dependent
R11965 T15674 T15673 arg2Of inhibit,can
R11966 T15675 T15674 arg2Of expression,inhibit
R11967 T15675 T15676 arg1Of expression,of
R11968 T15677 T15676 arg2Of bcl6,of
R11969 T15677 T15678 arg1Of bcl6,","
R11970 T15681 T15678 arg2Of factor,","
R11971 T15681 T15679 arg1Of factor,a
R11972 T15681 T15680 arg1Of factor,transcription
R11973 T15681 T15682 arg1Of factor,necessary
R11974 T15682 T15683 arg1Of necessary,for
R11975 T15685 T15683 arg2Of formation,for
R11976 T15685 T15684 arg1Of formation,GC
R11977 T15685 T15686 arg1Of formation,[
R11978 T15687 T15686 arg2Of "49,70",[
R11979 T15688 T15686 arg3Of ],[
R11980 T15689 T15690 arg1Of It,has
R11981 T15689 T15691 arg1Of It,been
R11982 T15689 T15692 arg2Of It,shown
R11983 T15692 T15690 arg2Of shown,has
R11984 T15692 T15691 arg2Of shown,been
R11985 T15694 T15695 arg1Of overstimulation,of
R11986 T15694 T15698 arg1Of overstimulation,with
R11987 T15694 T15701 arg1Of overstimulation,inhibits
R11988 T15697 T15695 arg2Of signaling,of
R11989 T15697 T15696 arg1Of signaling,CD40
R11990 T15700 T15698 arg2Of antibodies,with
R11991 T15700 T15699 arg1Of antibodies,agonistic
R11992 T15701 T15692 arg3Of inhibits,shown
R11993 T15701 T15693 arg1Of inhibits,that
R11994 T15703 T15701 arg2Of formation,inhibits
R11995 T15703 T15702 arg1Of formation,GC
R11996 T15703 T15704 arg1Of formation,[
R11997 T15705 T15704 arg2Of 71,[
R11998 T15706 T15704 arg3Of ],[
R11999 T15710 T15709 arg1Of to,due
R12000 T15711 T15710 arg2Of mimicry,to
R12001 T15711 T15712 arg1Of mimicry,of
R12002 T15714 T15712 arg2Of signaling,of
R12003 T15714 T15713 arg1Of signaling,CD40
R12004 T15718 T15716 arg1Of mice,transgenic
R12005 T15718 T15717 arg1Of mice,LMP1
R12006 T15718 T15719 arg1Of mice,are
R12007 T15718 T15721 arg1Of mice,defective
R12008 T15719 T15707 arg1Of are,Similarly
R12009 T15719 T15708 arg1Of are,","
R12010 T15719 T15710 arg1Of are,to
R12011 T15719 T15715 arg1Of are,","
R12012 T15719 T15720 arg1Of are,also
R12013 T15721 T15719 arg2Of defective,are
R12014 T15721 T15722 arg1Of defective,in
R12015 T15724 T15722 arg2Of formation,in
R12016 T15724 T15723 arg1Of formation,GC
R12017 T15724 T15725 arg1Of formation,[
R12018 T15726 T15725 arg2Of "23,49",[
R12019 T15727 T15725 arg3Of ],[
R12020 T15730 T15728 arg1Of signaling,The
R12021 T15730 T15729 arg1Of signaling,constitutive
R12022 T15730 T15731 arg1Of signaling,by
R12023 T15730 T15734 arg1Of signaling,blocks
R12024 T15732 T15731 arg2Of LMP1,by
R12025 T15734 T15733 arg1Of blocks,likely
R12026 T15734 T15737 arg1Of blocks,through
R12027 T15736 T15734 arg2Of formation,blocks
R12028 T15736 T15735 arg1Of formation,GC
R12029 T15738 T15737 arg2Of downregulation,through
R12030 T15738 T15739 arg1Of downregulation,of
R12031 T15740 T15739 arg2Of bcl6,of
R12032 T15744 T15743 arg1Of studies,clinical
R12033 T15744 T15745 arg1Of studies,indicate
R12034 T15745 T15741 arg1Of indicate,Interestingly
R12035 T15745 T15742 arg1Of indicate,","
R12036 T15747 T15748 arg1Of expression,of
R12037 T15747 T15752 arg1Of expression,are
R12038 T15747 T15754 arg1Of expression,exclusive
R12039 T15749 T15750 arg1Of LMP1,and
R12040 T15750 T15748 arg2Of and,of
R12041 T15751 T15750 arg2Of bcl6,and
R12042 T15752 T15745 arg2Of are,indicate
R12043 T15752 T15746 arg1Of are,that
R12044 T15754 T15752 arg2Of exclusive,are
R12045 T15754 T15753 arg1Of exclusive,mutually
R12046 T15754 T15755 arg1Of exclusive,in
R12047 T15756 T15757 arg1Of non-HD,and
R12048 T15758 T15757 arg2Of classical,and
R12049 T15759 T15755 arg2Of HD,in
R12050 T15759 T15756 arg1Of HD,non-HD
R12051 T15759 T15758 arg1Of HD,classical
R12052 T15759 T15760 arg1Of HD,[
R12053 T15761 T15760 arg2Of "72,73",[
R12054 T15762 T15760 arg3Of ],[
R12055 T15768 T15765 arg1Of lymphomas,the
R12056 T15768 T15766 arg1Of lymphomas,LMP1
R12057 T15768 T15767 arg1Of lymphomas,transgenic
R12058 T15768 T15769 arg1Of lymphomas,mirror
R12059 T15769 T15763 arg1Of mirror,Thus
R12060 T15769 T15764 arg1Of mirror,","
R12061 T15770 T15769 arg2Of aspects,mirror
R12062 T15770 T15771 arg1Of aspects,of
R12063 T15773 T15771 arg2Of HD,of
R12064 T15773 T15772 arg1Of HD,EBV-induced
R12065 T15776 T15775 arg1Of activation,the
R12066 T15776 T15777 arg1Of activation,of
R12067 T15776 T15779 arg1Of activation,and
R12068 T15778 T15777 arg2Of Akt,of
R12069 T15779 T15788 arg1Of and,suggest
R12070 T15781 T15779 arg2Of lack,and
R12071 T15781 T15780 arg1Of lack,the
R12072 T15781 T15782 arg1Of lack,of
R12073 T15781 T15784 arg1Of lack,in
R12074 T15783 T15782 arg2Of Fox01,of
R12075 T15787 T15784 arg2Of cells,in
R12076 T15787 T15785 arg1Of cells,the
R12077 T15787 T15786 arg1Of cells,lymphoma
R12078 T15788 T15774 arg2Of suggest,Although
R12079 T15790 T15791 arg1Of LMP1,affects
R12080 T15791 T15788 arg2Of affects,suggest
R12081 T15791 T15789 arg1Of affects,that
R12082 T15791 T15796 arg1Of affects,through
R12083 T15792 T15793 arg1Of bcl6,and
R12084 T15794 T15793 arg2Of GC,and
R12085 T15795 T15791 arg2Of formation,affects
R12086 T15795 T15792 arg1Of formation,bcl6
R12087 T15795 T15794 arg1Of formation,GC
R12088 T15798 T15796 arg2Of pathway,through
R12089 T15798 T15797 arg1Of pathway,this
R12090 T15800 T15801 arg1Of regulation,of
R12091 T15800 T15818 arg1Of regulation,contribute
R12092 T15804 T15801 arg2Of targets,of
R12093 T15804 T15802 arg1Of targets,other
R12094 T15804 T15803 arg1Of targets,Forkhead
R12095 T15804 T15805 arg2Of targets,involved
R12096 T15804 T15810 arg1Of targets,","
R12097 T15804 T15812 arg1Of targets,as
R12098 T15805 T15806 arg1Of involved,in
R12099 T15809 T15806 arg2Of progression,in
R12100 T15809 T15807 arg1Of progression,cell
R12101 T15809 T15808 arg1Of progression,cycle
R12102 T15812 T15811 arg1Of as,such
R12103 T15813 T15814 arg1Of p27,and
R12104 T15814 T15812 arg2Of and,as
R12105 T15815 T15814 arg2Of CyclinD2,and
R12106 T15818 T15774 arg1Of contribute,Although
R12107 T15818 T15799 arg1Of contribute,","
R12108 T15818 T15816 arg1Of contribute,","
R12109 T15818 T15817 arg1Of contribute,likely
R12110 T15818 T15819 arg1Of contribute,to
R12111 T15821 T15819 arg2Of transformation,to
R12112 T15821 T15820 arg1Of transformation,malignant
R12113 T15824 T15825 arg1Of loss,of
R12114 T15824 T15828 arg1Of loss,in
R12115 T15824 T15831 arg1Of loss,correlated
R12116 T15827 T15825 arg2Of expression,of
R12117 T15827 T15826 arg1Of expression,FoxO1
R12118 T15830 T15828 arg2Of cells,in
R12119 T15830 T15829 arg1Of cells,lymphoma
R12120 T15831 T15822 arg1Of correlated,Indeed
R12121 T15831 T15823 arg1Of correlated,","
R12122 T15831 T15832 arg1Of correlated,with
R12123 T15834 T15832 arg2Of loss,with
R12124 T15834 T15833 arg1Of loss,a
R12125 T15834 T15835 arg1Of loss,of
R12126 T15834 T15837 arg1Of loss,(
R12127 T15836 T15835 arg2Of p27,of
R12128 T15839 T15838 arg1Of 6B,Figure
R12129 T15839 T15840 arg1Of 6B,and
R12130 T15840 T15837 arg2Of and,(
R12131 T15841 T15840 arg2Of 6C,and
R12132 T15842 T15837 arg3Of ),(
R12133 T15843 T15844 arg1Of CyclinD2,has
R12134 T15843 T15846 arg1Of CyclinD2,been
R12135 T15843 T15847 arg2Of CyclinD2,shown
R12136 T15843 T15849 arg1Of CyclinD2,be
R12137 T15843 T15850 arg2Of CyclinD2,upregulated
R12138 T15847 T15844 arg2Of shown,has
R12139 T15847 T15845 arg1Of shown,also
R12140 T15847 T15846 arg2Of shown,been
R12141 T15850 T15847 arg3Of upregulated,shown
R12142 T15850 T15848 arg1Of upregulated,to
R12143 T15850 T15849 arg2Of upregulated,be
R12144 T15850 T15853 arg1Of upregulated,through
R12145 T15850 T15858 arg1Of upregulated,[
R12146 T15852 T15850 arg1Of LMP1,upregulated
R12147 T15852 T15851 arg2Of LMP1,by
R12148 T15854 T15853 arg2Of release,through
R12149 T15854 T15855 arg1Of release,of
R12150 T15857 T15855 arg2Of repression,of
R12151 T15857 T15856 arg1Of repression,FoxO1-mediated
R12152 T15859 T15858 arg2Of 70,[
R12153 T15860 T15858 arg3Of ],[
R12154 T15862 T15861 arg2Of summary,In
R12155 T15867 T15864 arg2Of model,in
R12156 T15867 T15865 arg1Of model,this
R12157 T15867 T15866 arg1Of model,transgenic
R12158 T15867 T15868 arg1Of model,of
R12159 T15869 T15868 arg2Of lymphomagenesis,of
R12160 T15871 T15872 arg1Of LMP1,promotes
R12161 T15872 T15861 arg1Of promotes,In
R12162 T15872 T15863 arg1Of promotes,","
R12163 T15872 T15864 arg1Of promotes,in
R12164 T15872 T15870 arg1Of promotes,","
R12165 T15873 T15872 arg2Of malignancy,promotes
R12166 T15873 T15874 arg1Of malignancy,in
R12167 T15876 T15874 arg2Of cells,in
R12168 T15876 T15875 arg1Of cells,B-1a
R12169 T15876 T15877 arg1Of cells,","
R12170 T15879 T15877 arg2Of population,","
R12171 T15879 T15878 arg1Of population,a
R12172 T15879 T15880 arg1Of population,that
R12173 T15879 T15881 arg1Of population,is
R12174 T15879 T15882 arg2Of population,predisposed
R12175 T15882 T15881 arg2Of predisposed,is
R12176 T15882 T15883 arg1Of predisposed,to
R12177 T15885 T15883 arg2Of expansion,to
R12178 T15885 T15884 arg1Of expansion,clonal
R12179 T15885 T15886 arg1Of expansion,with
R12180 T15887 T15886 arg2Of age,with
R12181 T15890 T15888 arg1Of lymphocytes,The
R12182 T15890 T15889 arg1Of lymphocytes,malignant
R12183 T15890 T15891 arg1Of lymphocytes,were
R12184 T15890 T15892 arg2Of lymphocytes,distinguished
R12185 T15890 T15903 arg1Of lymphocytes,activated
R12186 T15892 T15891 arg2Of distinguished,were
R12187 T15892 T15902 arg1Of distinguished,and
R12188 T15895 T15894 arg1Of active,constitutively
R12189 T15897 T15892 arg1Of signaling,distinguished
R12190 T15897 T15893 arg2Of signaling,by
R12191 T15897 T15895 arg1Of signaling,active
R12192 T15897 T15896 arg1Of signaling,Stat3
R12193 T15897 T15898 arg1Of signaling,","
R12194 T15900 T15898 arg2Of p27,","
R12195 T15900 T15899 arg2Of p27,decreased
R12196 T15902 T15901 arg1Of and,","
R12197 T15903 T15902 arg2Of activated,and
R12198 T15904 T15905 arg1Of Akt,and
R12199 T15905 T15903 arg2Of and,activated
R12200 T15905 T15908 arg1Of and,","
R12201 T15907 T15905 arg2Of pathways,and
R12202 T15907 T15906 arg1Of pathways,NFκB
R12203 T15909 T15908 arg2Of properties,","
R12204 T15909 T15910 arg1Of properties,that
R12205 T15909 T15911 arg1Of properties,are
R12206 T15909 T15912 arg2Of properties,associated
R12207 T15912 T15911 arg2Of associated,are
R12208 T15912 T15913 arg1Of associated,with
R12209 T15914 T15913 arg2Of promoting,with
R12210 T15916 T15917 arg1Of growth,and
R12211 T15917 T15914 arg2Of and,promoting
R12212 T15917 T15915 arg1Of and,the
R12213 T15917 T15919 arg1Of and,of
R12214 T15918 T15917 arg2Of survival,and
R12215 T15921 T15919 arg2Of lymphocytes,of
R12216 T15921 T15920 arg1Of lymphocytes,B
R12217 T15924 T15925 arg1Of Akt,","
R12218 T15925 T15928 arg1Of ",",and
R12219 T15926 T15925 arg2Of NFκB,","
R12220 T15928 T15927 arg1Of and,","
R12221 T15928 T15931 arg1Of and,were
R12222 T15928 T15933 arg2Of and,required
R12223 T15930 T15928 arg2Of pathways,and
R12224 T15930 T15929 arg1Of pathways,Stat3
R12225 T15933 T15922 arg1Of required,Importantly
R12226 T15933 T15923 arg1Of required,","
R12227 T15933 T15931 arg2Of required,were
R12228 T15933 T15932 arg1Of required,critically
R12229 T15933 T15934 arg1Of required,for
R12230 T15936 T15937 arg1Of growth,and
R12231 T15937 T15934 arg2Of and,for
R12232 T15937 T15935 arg1Of and,the
R12233 T15937 T15939 arg1Of and,of
R12234 T15938 T15937 arg2Of survival,and
R12235 T15941 T15940 arg1Of lymphocytes,malignant
R12236 T15941 T15944 arg1Of lymphocytes,as
R12237 T15944 T15939 arg2Of as,of
R12238 T15944 T15942 arg1Of as,as
R12239 T15944 T15943 arg1Of as,well
R12240 T15948 T15944 arg2Of lymphocytes,as
R12241 T15948 T15945 arg1Of lymphocytes,healthy
R12242 T15948 T15946 arg1Of lymphocytes,LMP1
R12243 T15948 T15947 arg1Of lymphocytes,transgenic
R12244 T15950 T15949 arg1Of growth,The
R12245 T15950 T15951 arg1Of growth,of
R12246 T15950 T15955 arg1Of growth,requires
R12247 T15953 T15951 arg2Of lymphocytes,of
R12248 T15953 T15952 arg1Of lymphocytes,EBV-transformed
R12249 T15955 T15954 arg1Of requires,also
R12250 T15955 T15960 arg1Of requires,and
R12251 T15956 T15955 arg2Of activation,requires
R12252 T15956 T15957 arg1Of activation,of
R12253 T15958 T15957 arg2Of NFκB,of
R12254 T15960 T15959 arg1Of and,","
R12255 T15962 T15961 arg1Of studies,these
R12256 T15962 T15963 arg1Of studies,provide
R12257 T15963 T15960 arg2Of provide,and
R12258 T15964 T15963 arg2Of insight,provide
R12259 T15964 T15965 arg1Of insight,into
R12260 T15966 T15965 arg2Of how,into
R12261 T15967 T15968 arg1Of LMP1,contributes
R12262 T15968 T15966 arg1Of contributes,how
R12263 T15968 T15969 arg1Of contributes,to
R12264 T15971 T15969 arg2Of transformation,to
R12265 T15971 T15970 arg1Of transformation,EBV-associated
R12266 T15974 T15972 arg1Of lymphomas,The
R12267 T15974 T15973 arg1Of lymphomas,transgenic
R12268 T15974 T15975 arg1Of lymphomas,mirror
R12269 T15974 T15982 arg1Of lymphomas,suggest
R12270 T15975 T15981 arg1Of mirror,and
R12271 T15977 T15975 arg2Of aspects,mirror
R12272 T15977 T15976 arg1Of aspects,multiple
R12273 T15977 T15978 arg1Of aspects,of
R12274 T15980 T15978 arg2Of tumors,of
R12275 T15980 T15979 arg1Of tumors,EBV-induced
R12276 T15982 T15981 arg2Of suggest,and
R12277 T15985 T15984 arg1Of vivo,in
R12278 T15987 T15986 arg1Of properties,these
R12279 T15987 T15988 arg1Of properties,of
R12280 T15987 T15990 arg1Of properties,are
R12281 T15989 T15988 arg2Of LMP1,of
R12282 T15990 T15982 arg2Of are,suggest
R12283 T15990 T15983 arg1Of are,that
R12284 T15990 T15985 arg1Of are,vivo
R12285 T15992 T15990 arg2Of factors,are
R12286 T15992 T15991 arg1Of factors,major
R12287 T15992 T15993 arg1Of factors,in
R12288 T15995 T15993 arg2Of development,in
R12289 T15995 T15994 arg1Of development,the
R12290 T15995 T15996 arg1Of development,of
R12291 T15997 T15996 arg2Of cancer,of
R14045 T18296 T18295 arg1Of mice,Transgenic
R14046 T18297 T18298 arg1Of Generation,of
R14047 T18297 T18301 arg1Of Generation,under
R14048 T18297 T18309 arg1Of Generation,have
R14049 T18297 T18310 arg1Of Generation,been
R14050 T18297 T18311 arg2Of Generation,described
R14051 T18297 T18314 arg1Of Generation,were
R14052 T18297 T18315 arg2Of Generation,maintained
R14053 T18300 T18298 arg2Of mice,of
R14054 T18300 T18299 arg1Of mice,LMP1
R14055 T18306 T18302 arg1Of promoter,the
R14056 T18306 T18303 arg1Of promoter,Ig
R14057 T18306 T18304 arg1Of promoter,heavy
R14058 T18306 T18305 arg1Of promoter,chain
R14059 T18306 T18307 arg1Of promoter,and
R14060 T18307 T18301 arg2Of and,under
R14061 T18308 T18307 arg2Of enhancer,and
R14062 T18311 T18309 arg2Of described,have
R14063 T18311 T18310 arg2Of described,been
R14064 T18311 T18312 arg1Of described,previously
R14065 T18311 T18313 arg1Of described,and
R14066 T18313 T18322 arg1Of and,[
R14067 T18315 T18313 arg2Of maintained,and
R14068 T18315 T18314 arg2Of maintained,were
R14069 T18315 T18316 arg1Of maintained,as
R14070 T18315 T18318 arg1Of maintained,on
R14071 T18317 T18316 arg2Of heterozygotes,as
R14072 T18321 T18318 arg2Of background,on
R14073 T18321 T18319 arg1Of background,a
R14074 T18321 T18320 arg1Of background,Balbc
R14075 T18323 T18322 arg2Of 26,[
R14076 T18324 T18322 arg3Of ],[
R14077 T18326 T18325 arg1Of mice,LMP1
R14078 T18326 T18327 arg1Of mice,were
R14079 T18326 T18328 arg2Of mice,genotyped
R14080 T18328 T18327 arg2Of genotyped,were
R14081 T18328 T18338 arg1Of genotyped,as
R14082 T18331 T18332 arg1Of blot,and
R14083 T18333 T18332 arg2Of PCR,and
R14084 T18334 T18328 arg1Of analysis,genotyped
R14085 T18334 T18329 arg2Of analysis,by
R14086 T18334 T18330 arg1Of analysis,Southern
R14087 T18334 T18331 arg1Of analysis,blot
R14088 T18334 T18333 arg1Of analysis,PCR
R14089 T18334 T18335 arg1Of analysis,of
R14090 T18337 T18335 arg2Of DNA,of
R14091 T18337 T18336 arg1Of DNA,tail
R14092 T18339 T18338 arg2Of described,as
R14093 T18339 T18340 arg1Of described,previously
R14094 T18339 T18341 arg1Of described,[
R14095 T18342 T18341 arg2Of 26,[
R14096 T18343 T18341 arg3Of ],[
R14097 T18344 T18345 arg1Of Spleen,and
R14098 T18346 T18345 arg2Of liver,and
R14099 T18347 T18344 arg1Of sections,Spleen
R14100 T18347 T18346 arg1Of sections,liver
R14101 T18347 T18348 arg1Of sections,were
R14102 T18347 T18349 arg2Of sections,fixed
R14103 T18347 T18355 arg2Of sections,embedded
R14104 T18349 T18350 arg1Of fixed,in
R14105 T18349 T18354 arg1Of fixed,and
R14106 T18351 T18352 arg1Of 4,%
R14107 T18353 T18350 arg2Of paraformaldehyde,in
R14108 T18353 T18351 arg1Of paraformaldehyde,4
R14109 T18354 T18348 arg2Of and,were
R14110 T18354 T18359 arg1Of and,and
R14111 T18355 T18354 arg2Of embedded,and
R14112 T18355 T18356 arg1Of embedded,in
R14113 T18357 T18356 arg2Of paraffin,in
R14114 T18359 T18358 arg1Of and,","
R14115 T18361 T18360 arg1Of sections,5-μm
R14116 T18361 T18362 arg1Of sections,were
R14117 T18361 T18363 arg2Of sections,stained
R14118 T18363 T18359 arg2Of stained,and
R14119 T18363 T18362 arg2Of stained,were
R14120 T18363 T18364 arg1Of stained,with
R14121 T18365 T18366 arg1Of hematoxylin,and
R14122 T18366 T18364 arg2Of and,with
R14123 T18366 T18368 arg1Of and,for
R14124 T18367 T18366 arg2Of eosin,and
R14125 T18370 T18368 arg2Of analysis,for
R14126 T18370 T18369 arg1Of analysis,histopathological
R14127 T18371 T18372 arg1Of Lymphomas,were
R14128 T18371 T18373 arg2Of Lymphomas,passaged
R14129 T18371 T18386 arg2Of Lymphomas,sacrificed
R14130 T18373 T18382 arg1Of passaged,into
R14131 T18373 T18385 arg1Of passaged,and
R14132 T18376 T18373 arg1Of injection,passaged
R14133 T18376 T18374 arg2Of injection,by
R14134 T18376 T18375 arg1Of injection,intraperitoneal
R14135 T18376 T18377 arg1Of injection,of
R14136 T18381 T18377 arg2Of splenocytes,of
R14137 T18381 T18378 arg1Of splenocytes,1
R14138 T18381 T18379 arg1Of splenocytes,×
R14139 T18381 T18380 arg1Of splenocytes,108
R14140 T18384 T18382 arg2Of mice,into
R14141 T18384 T18383 arg1Of mice,SCID
R14142 T18385 T18372 arg2Of and,were
R14143 T18386 T18385 arg2Of sacrificed,and
R14144 T18386 T18387 arg1Of sacrificed,upon
R14145 T18388 T18387 arg2Of development,upon
R14146 T18388 T18389 arg1Of development,of
R14147 T18392 T18389 arg2Of abdomen,of
R14148 T18392 T18390 arg1Of abdomen,an
R14149 T18392 T18391 arg2Of abdomen,extended
R14150 T18393 T18394 arg1Of Animals,were
R14151 T18393 T18395 arg2Of Animals,housed
R14152 T18395 T18394 arg2Of housed,were
R14153 T18395 T18396 arg1Of housed,in
R14154 T18398 T18396 arg2Of Association,in
R14155 T18398 T18397 arg1Of Association,the
R14156 T18398 T18399 arg1Of Association,for
R14157 T18398 T18403 arg1Of Association,for
R14158 T18400 T18401 arg1Of Assessment,and
R14159 T18401 T18399 arg2Of and,for
R14160 T18402 T18401 arg2Of Accreditation,and
R14161 T18405 T18404 arg1Of Care–approved,Animal
R14162 T18407 T18403 arg2Of facility,for
R14163 T18407 T18405 arg1Of facility,Care–approved
R14164 T18407 T18406 arg1Of facility,animal
R14165 T18407 T18408 arg1Of facility,at
R14166 T18407 T18414 arg1Of facility,at
R14167 T18407 T18419 modOf facility,were
R14168 T18410 T18408 arg2Of University,at
R14169 T18410 T18409 arg1Of University,the
R14170 T18410 T18411 arg1Of University,of
R14171 T18413 T18411 arg2Of Carolina,of
R14172 T18413 T18412 arg1Of Carolina,North
R14173 T18416 T18414 arg2Of Hill.,at
R14174 T18416 T18415 arg1Of Hill.,Chapel
R14175 T18418 T18417 arg1Of protocols,All
R14176 T18418 T18419 arg1Of protocols,were
R14177 T18418 T18420 arg2Of protocols,approved
R14178 T18420 T18419 arg2Of approved,were
R14179 T18425 T18423 arg1Of Care,Institutional
R14180 T18425 T18424 arg1Of Care,Animal
R14181 T18425 T18426 arg1Of Care,and
R14182 T18426 T18420 arg1Of and,approved
R14183 T18426 T18421 arg2Of and,by
R14184 T18426 T18422 arg1Of and,the
R14185 T18428 T18426 arg2Of Committee,and
R14186 T18428 T18427 arg1Of Committee,Use
R14329 T18617 T18618 arg1Of Isolation,and
R14330 T18618 T18620 arg1Of and,of
R14331 T18619 T18618 arg2Of growth,and
R14332 T18622 T18620 arg2Of cells,of
R14333 T18622 T18621 arg1Of cells,B
R14334 T18623 T18624 arg1Of Splenocytes,were
R14335 T18623 T18625 arg2Of Splenocytes,prepared
R14336 T18625 T18624 arg2Of prepared,were
R14337 T18625 T18626 arg1Of prepared,by
R14338 T18625 T18634 arg1Of prepared,and
R14339 T18627 T18626 arg2Of homogenizing,by
R14340 T18627 T18630 arg1Of homogenizing,with
R14341 T18629 T18627 arg2Of tissue,homogenizing
R14342 T18629 T18628 arg1Of tissue,spleen
R14343 T18633 T18630 arg2Of slides,with
R14344 T18633 T18631 arg1Of slides,two
R14345 T18633 T18632 arg1Of slides,frosted
R14346 T18635 T18636 arg1Of debris,was
R14347 T18635 T18637 arg2Of debris,filtered
R14348 T18637 T18634 arg2Of filtered,and
R14349 T18637 T18636 arg2Of filtered,was
R14350 T18637 T18638 arg1Of filtered,through
R14351 T18642 T18638 arg2Of strainer,through
R14352 T18642 T18639 arg1Of strainer,a
R14353 T18642 T18640 arg1Of strainer,100-μm
R14354 T18642 T18641 arg1Of strainer,cell
R14355 T18643 T18644 arg1Of Erythrocytes,were
R14356 T18643 T18645 arg2Of Erythrocytes,lysed
R14357 T18643 T18662 arg2Of Erythrocytes,washed
R14358 T18645 T18661 arg1Of lysed,and
R14359 T18646 T18645 arg3Of using,lysed
R14360 T18647 T18648 arg1Of 0.8,%
R14361 T18651 T18646 arg2Of solution,using
R14362 T18651 T18647 arg1Of solution,0.8
R14363 T18651 T18649 arg1Of solution,ammonium
R14364 T18651 T18650 arg1Of solution,chloride
R14365 T18651 T18652 arg1Of solution,(
R14366 T18651 T18656 arg1Of solution,for
R14367 T18651 T18659 arg1Of solution,on
R14368 T18654 T18652 arg2Of Technologies,(
R14369 T18654 T18653 arg1Of Technologies,StemCell
R14370 T18655 T18652 arg3Of ),(
R14371 T18658 T18656 arg2Of min,for
R14372 T18658 T18657 arg1Of min,10
R14373 T18660 T18659 arg2Of ice,on
R14374 T18661 T18644 arg2Of and,were
R14375 T18662 T18661 arg2Of washed,and
R14376 T18662 T18663 arg1Of washed,twice
R14377 T18662 T18664 arg1Of washed,with
R14378 T18665 T18664 arg2Of PBS,with
R14379 T18667 T18666 arg1Of cells,B
R14380 T18667 T18668 arg1Of cells,were
R14381 T18667 T18669 arg2Of cells,isolated
R14382 T18667 T18684 arg2Of cells,grown
R14383 T18669 T18670 modOf isolated,using
R14384 T18669 T18673 arg1Of isolated,according
R14385 T18669 T18683 arg1Of isolated,and
R14386 T18672 T18670 arg2Of beads,using
R14387 T18672 T18671 arg1Of beads,CD19-MACS
R14388 T18674 T18673 arg2Of to,according
R14389 T18676 T18675 arg1Of manufacturer,the
R14390 T18676 T18677 arg2Of manufacturer,'s
R14391 T18678 T18674 arg2Of instructions,to
R14392 T18678 T18677 arg1Of instructions,'s
R14393 T18678 T18679 arg1Of instructions,(
R14394 T18681 T18679 arg2Of Biotec,(
R14395 T18681 T18680 arg1Of Biotec,Miltenyi
R14396 T18682 T18679 arg3Of ),(
R14397 T18683 T18668 arg2Of and,were
R14398 T18684 T18683 arg2Of grown,and
R14399 T18684 T18685 arg1Of grown,in
R14400 T18686 T18687 arg2Of Iscove,'s
R14401 T18688 T18685 arg2Of medium,in
R14402 T18688 T18687 arg1Of medium,'s
R14403 T18688 T18689 arg2Of medium,supplemented
R14404 T18689 T18690 arg1Of supplemented,with
R14405 T18692 T18693 arg1Of 10,%
R14406 T18696 T18691 arg1Of serum,heat-inactivated
R14407 T18696 T18692 arg1Of serum,10
R14408 T18696 T18694 arg1Of serum,fetal
R14409 T18696 T18695 arg1Of serum,bovine
R14410 T18696 T18697 arg1Of serum,and
R14411 T18697 T18690 arg2Of and,with
R14412 T18698 T18697 arg2Of antibiotic/antimycotic,and
R14413 T18698 T18699 arg1Of antibiotic/antimycotic,(
R14414 T18700 T18699 arg2Of GIBCO,(
R14415 T18701 T18699 arg3Of ),(
R14416 T18702 T18703 arg2Of Splenocytes,isolated
R14417 T18702 T18707 arg1Of Splenocytes,consisted
R14418 T18702 T18722 arg1Of Splenocytes,were
R14419 T18702 T18726 arg2Of Splenocytes,purified
R14420 T18703 T18704 arg1Of isolated,from
R14421 T18706 T18704 arg2Of lymphomas,from
R14422 T18706 T18705 arg1Of lymphomas,SCID-passaged
R14423 T18707 T18708 arg1Of consisted,of
R14424 T18707 T18715 arg1Of consisted,as
R14425 T18707 T18721 arg1Of consisted,and
R14426 T18711 T18712 arg1Of –90,%
R14427 T18714 T18708 arg2Of cells,of
R14428 T18714 T18709 arg1Of cells,80
R14429 T18714 T18710 arg1Of cells,%
R14430 T18714 T18711 arg1Of cells,–90
R14431 T18714 T18713 arg1Of cells,B
R14432 T18716 T18715 arg2Of determined,as
R14433 T18719 T18716 arg1Of cytometry,determined
R14434 T18719 T18717 arg2Of cytometry,by
R14435 T18719 T18718 arg1Of cytometry,flow
R14436 T18721 T18720 arg1Of and,","
R14437 T18725 T18724 arg1Of further,not
R14438 T18726 T18721 arg2Of purified,and
R14439 T18726 T18722 arg2Of purified,were
R14440 T18726 T18723 arg1Of purified,hence
R14441 T18726 T18725 arg1Of purified,further
R14442 T18726 T18727 arg1Of purified,with
R14443 T18729 T18727 arg2Of beads,with
R14444 T18729 T18728 arg1Of beads,CD19-MACS
R14445 T18730 T18731 arg1Of Splenocytes,were
R14446 T18730 T18732 arg2Of Splenocytes,seeded
R14447 T18732 T18731 arg2Of seeded,were
R14448 T18732 T18733 arg1Of seeded,at
R14449 T18734 T18735 arg1Of 1.25,×
R14450 T18736 T18735 arg2Of 106,×
R14451 T18737 T18734 arg1Of cells/ml,1.25
R14452 T18737 T18736 arg1Of cells/ml,106
R14453 T18737 T18738 arg1Of cells/ml,and
R14454 T18738 T18733 arg2Of and,at
R14455 T18739 T18738 arg2Of where,and
R14456 T18740 T18741 arg1Of applicable,","
R14457 T18742 T18741 arg2Of recombinant,","
R14458 T18744 T18740 arg1Of IL4,applicable
R14459 T18744 T18742 arg1Of IL4,recombinant
R14460 T18744 T18743 arg1Of IL4,mouse
R14461 T18744 T18745 arg1Of IL4,was
R14462 T18744 T18746 arg2Of IL4,added
R14463 T18746 T18739 arg1Of added,where
R14464 T18746 T18745 arg2Of added,was
R14465 T18746 T18747 arg1Of added,at
R14466 T18746 T18771 arg1Of added,(
R14467 T18749 T18748 arg1Of ng/ml,100
R14468 T18749 T18750 arg1Of ng/ml,","
R14469 T18750 T18758 arg1Of ",",and
R14470 T18753 T18750 arg2Of IL10,","
R14471 T18753 T18751 arg1Of IL10,recombinant
R14472 T18753 T18752 arg1Of IL10,mouse
R14473 T18753 T18754 arg1Of IL10,at
R14474 T18756 T18754 arg2Of ng/ml,at
R14475 T18756 T18755 arg1Of ng/ml,10
R14476 T18758 T18747 arg2Of and,at
R14477 T18758 T18757 arg1Of and,","
R14478 T18762 T18759 arg1Of IL10,rat
R14479 T18762 T18760 arg1Of IL10,IgG1
R14480 T18762 T18761 arg1Of IL10,anti-mouse
R14481 T18762 T18763 arg1Of IL10,and
R14482 T18763 T18758 arg2Of and,and
R14483 T18763 T18768 arg1Of and,at
R14484 T18767 T18763 arg2Of control,and
R14485 T18767 T18764 arg1Of control,rat
R14486 T18767 T18765 arg1Of control,IgG1
R14487 T18767 T18766 arg1Of control,isotype
R14488 T18770 T18768 arg2Of μg/ml,at
R14489 T18770 T18769 arg1Of μg/ml,10
R14490 T18775 T18771 arg2Of Systems,(
R14491 T18775 T18772 arg1Of Systems,R
R14492 T18775 T18773 arg1Of Systems,&
R14493 T18775 T18774 arg1Of Systems,D
R14494 T18776 T18771 arg3Of ),(
R14495 T18780 T18777 arg2Of assays,For
R14496 T18780 T18778 arg1Of assays,BrdU
R14497 T18780 T18779 arg1Of assays,incorporation
R14498 T18782 T18783 arg1Of splenocytes,were
R14499 T18782 T18784 arg2Of splenocytes,pulsed
R14500 T18784 T18777 arg1Of pulsed,For
R14501 T18784 T18781 arg1Of pulsed,","
R14502 T18784 T18783 arg2Of pulsed,were
R14503 T18784 T18785 arg1Of pulsed,for
R14504 T18784 T18788 arg1Of pulsed,with
R14505 T18787 T18785 arg2Of h,for
R14506 T18787 T18786 arg1Of h,24
R14507 T18791 T18790 arg1Of BrdU,μM
R14508 T18791 T18792 arg1Of BrdU,1
R14509 T18793 T18788 arg2Of d,with
R14510 T18793 T18789 arg1Of d,10
R14511 T18793 T18791 arg1Of d,BrdU
R14512 T18793 T18794 arg1Of d,post-harvest
R14700 T19052 T19051 arg1Of assay,MTS
R14701 T19054 T19053 arg1Of 3-,The
R14702 T19054 T19055 arg1Of 3-,(
R14703 T19054 T19060 arg1Of 3-,-5-
R14704 T19054 T19061 arg1Of 3-,(
R14705 T19054 T19064 arg1Of 3-,-2-
R14706 T19054 T19077 modOf 3-,were
R14707 T19056 T19055 arg2Of 4,(
R14708 T19056 T19057 arg1Of 4,","
R14709 T19058 T19057 arg2Of 5-dimethylthiazol-2-yl,","
R14710 T19059 T19055 arg3Of ),(
R14711 T19062 T19061 arg2Of 3-carboxymethoxyphenyl,(
R14712 T19063 T19061 arg3Of ),(
R14713 T19066 T19065 arg2Of 4-sulfophenyl,(
R14714 T19067 T19065 arg3Of ),(
R14715 T19072 T19071 arg2Of MTS,(
R14716 T19073 T19071 arg3Of ),(
R14717 T19076 T19065 arg1Of assays,(
R14718 T19076 T19068 arg1Of assays,-2H-tetrazolium
R14719 T19076 T19069 arg1Of assays,inner
R14720 T19076 T19070 arg1Of assays,salt
R14721 T19076 T19071 arg1Of assays,(
R14722 T19076 T19074 arg1Of assays,cell
R14723 T19076 T19075 arg1Of assays,cytotoxicity/proliferation
R14724 T19076 T19077 arg1Of assays,were
R14725 T19076 T19078 arg2Of assays,performed
R14726 T19078 T19077 arg2Of performed,were
R14727 T19078 T19091 arg1Of performed,","
R14728 T19078 T19092 arg1Of performed,according
R14729 T19079 T19078 arg3Of using,performed
R14730 T19081 T19082 arg1Of CellTiter,96
R14731 T19087 T19079 arg2Of assay,using
R14732 T19087 T19080 arg1Of assay,the
R14733 T19087 T19081 arg1Of assay,CellTiter
R14734 T19087 T19083 arg1Of assay,aqueous
R14735 T19087 T19084 arg1Of assay,one-solution
R14736 T19087 T19085 arg1Of assay,cell
R14737 T19087 T19086 arg1Of assay,proliferation
R14738 T19087 T19088 arg1Of assay,(
R14739 T19089 T19088 arg2Of Promega,(
R14740 T19090 T19088 arg3Of ),(
R14741 T19093 T19092 arg2Of to,according
R14742 T19094 T19095 arg2Of manufacturer,'s
R14743 T19096 T19093 arg2Of instructions,to
R14744 T19096 T19095 arg1Of instructions,'s
R14745 T19099 T19097 arg2Of studies,For
R14746 T19099 T19098 arg1Of studies,IL4
R14747 T19101 T19102 arg1Of splenocytes,were
R14748 T19101 T19103 arg2Of splenocytes,cultured
R14749 T19103 T19097 arg1Of cultured,For
R14750 T19103 T19100 arg1Of cultured,","
R14751 T19103 T19102 arg2Of cultured,were
R14752 T19103 T19104 arg1Of cultured,for
R14753 T19103 T19107 arg1Of cultured,in
R14754 T19106 T19104 arg2Of d,for
R14755 T19106 T19105 arg1Of d,3
R14756 T19109 T19110 arg1Of presence,or
R14757 T19110 T19107 arg2Of or,in
R14758 T19110 T19108 arg1Of or,the
R14759 T19110 T19112 arg1Of or,of
R14760 T19111 T19110 arg2Of absence,or
R14761 T19113 T19114 arg1Of 100,ng/ml
R14762 T19115 T19112 arg2Of IL4,of
R14763 T19115 T19113 arg1Of IL4,100
R14764 T19116 T19117 arg1Of Cells,were
R14765 T19116 T19118 arg2Of Cells,seeded
R14766 T19118 T19117 arg2Of seeded,were
R14767 T19118 T19119 arg1Of seeded,on
R14768 T19118 T19122 arg1Of seeded,in
R14769 T19118 T19124 arg1Of seeded,in
R14770 T19120 T19119 arg2Of day,on
R14771 T19120 T19121 arg1Of day,3
R14772 T19123 T19122 arg2Of triplicate,in
R14773 T19127 T19124 arg2Of plate,in
R14774 T19127 T19125 arg1Of plate,a
R14775 T19127 T19126 arg1Of plate,96-well
R14776 T19127 T19128 arg1Of plate,at
R14777 T19127 T19133 arg1Of plate,at
R14778 T19129 T19130 arg1Of 2.5,×
R14779 T19131 T19130 arg2Of 106,×
R14780 T19132 T19128 arg2Of cells/ml,at
R14781 T19132 T19129 arg1Of cells/ml,2.5
R14782 T19132 T19131 arg1Of cells/ml,106
R14783 T19135 T19133 arg2Of μl,at
R14784 T19135 T19134 arg1Of μl,100
R14785 T19135 T19136 arg1Of μl,per
R14786 T19137 T19136 arg2Of well,per
R14787 T19139 T19138 arg1Of reagent,MTS
R14788 T19139 T19140 arg1Of reagent,was
R14789 T19139 T19141 arg2Of reagent,added
R14790 T19141 T19140 arg2Of added,was
R14791 T19141 T19142 arg1Of added,for
R14792 T19141 T19145 arg1Of added,and
R14793 T19144 T19142 arg2Of h,for
R14794 T19144 T19143 arg1Of h,4
R14795 T19145 T19152 arg1Of and,;
R14796 T19146 T19147 arg1Of absorbance,was
R14797 T19146 T19148 arg2Of absorbance,read
R14798 T19148 T19145 arg2Of read,and
R14799 T19148 T19147 arg2Of read,was
R14800 T19148 T19149 arg1Of read,at
R14801 T19151 T19149 arg2Of nm,at
R14802 T19151 T19150 arg1Of nm,540
R14803 T19153 T19154 arg2Of values,plotted
R14804 T19153 T19155 arg1Of values,were
R14805 T19153 T19156 arg2Of values,subtracted
R14806 T19156 T19152 arg2Of subtracted,;
R14807 T19156 T19155 arg2Of subtracted,were
R14808 T19156 T19157 arg1Of subtracted,from
R14809 T19158 T19157 arg2Of blanks,from
R14810 T19161 T19159 arg2Of assays,For
R14811 T19161 T19160 arg1Of assays,neutralization
R14812 T19163 T19164 arg1Of splenocytes,were
R14813 T19163 T19165 arg2Of splenocytes,seeded
R14814 T19165 T19159 arg1Of seeded,For
R14815 T19165 T19162 arg1Of seeded,","
R14816 T19165 T19164 arg2Of seeded,were
R14817 T19165 T19166 arg1Of seeded,at
R14818 T19165 T19170 arg1Of seeded,cells/ml
R14819 T19167 T19166 arg2Of 5,at
R14820 T19170 T19168 arg1Of cells/ml,×
R14821 T19170 T19169 arg1Of cells/ml,106
R14822 T19170 T19171 arg1Of cells/ml,at
R14823 T19170 T19199 modOf cells/ml,were
R14824 T19173 T19171 arg2Of μl,at
R14825 T19173 T19172 arg1Of μl,100
R14826 T19177 T19174 arg1Of day,per
R14827 T19177 T19175 arg1Of day,well
R14828 T19177 T19176 arg1Of day,on
R14829 T19177 T19178 arg1Of day,of
R14830 T19177 T19199 arg1Of day,were
R14831 T19177 T19200 arg2Of day,added
R14832 T19179 T19180 arg1Of harvest,and
R14833 T19180 T19182 arg1Of and,","
R14834 T19181 T19180 arg2Of IL4,and
R14835 T19182 T19188 arg1Of ",",or
R14836 T19186 T19182 arg2Of IL4,","
R14837 T19186 T19183 arg1Of IL4,rat
R14838 T19186 T19184 arg1Of IL4,IgG1
R14839 T19186 T19185 arg1Of IL4,anti-mouse
R14840 T19188 T19178 arg2Of or,of
R14841 T19188 T19187 arg1Of or,","
R14842 T19192 T19188 arg2Of control,or
R14843 T19192 T19189 arg1Of control,rat
R14844 T19192 T19190 arg1Of control,IgG1
R14845 T19192 T19191 arg1Of control,isotype
R14846 T19192 T19193 arg1Of control,(
R14847 T19197 T19193 arg2Of Systems,(
R14848 T19197 T19194 arg1Of Systems,R
R14849 T19197 T19195 arg1Of Systems,&
R14850 T19197 T19196 arg1Of Systems,D
R14851 T19198 T19193 arg3Of ),(
R14852 T19200 T19199 arg2Of added,were
R14853 T19200 T19201 arg1Of added,at
R14854 T19203 T19201 arg2Of concentrations,at
R14855 T19203 T19202 arg1Of concentrations,the
R14856 T19203 T19204 arg2Of concentrations,indicated
R14857 T19204 T19205 arg1Of indicated,in
R14858 T19207 T19205 arg2Of figures,in
R14859 T19207 T19206 arg1Of figures,the
R14860 T19208 T19209 arg1Of Cultures,were
R14861 T19208 T19210 arg2Of Cultures,pulsed
R14862 T19210 T19209 arg2Of pulsed,were
R14863 T19210 T19211 arg1Of pulsed,for
R14864 T19213 T19211 arg2Of h,for
R14865 T19213 T19212 arg1Of h,4
R14866 T19213 T19214 arg1Of h,with
R14867 T19218 T19214 arg2Of d,with
R14868 T19218 T19215 arg1Of d,MTS
R14869 T19218 T19216 arg1Of d,reagent
R14870 T19218 T19217 arg1Of d,1
R14871 T19218 T19219 arg1Of d,post-seeding
R14872 T19222 T19220 arg2Of studies,For
R14873 T19222 T19221 arg1Of studies,inhibitor
R14874 T19224 T19225 arg1Of splenocytes,were
R14875 T19224 T19226 arg2Of splenocytes,seeded
R14876 T19226 T19220 arg1Of seeded,For
R14877 T19226 T19223 arg1Of seeded,","
R14878 T19226 T19225 arg2Of seeded,were
R14879 T19226 T19227 arg1Of seeded,at
R14880 T19226 T19232 arg1Of seeded,at
R14881 T19226 T19242 arg1Of seeded,and
R14882 T19231 T19227 arg2Of cells/ml,at
R14883 T19231 T19228 arg1Of cells/ml,1
R14884 T19231 T19229 arg1Of cells/ml,×
R14885 T19231 T19230 arg1Of cells/ml,107
R14886 T19234 T19233 arg1Of μl,100
R14887 T19235 T19234 arg1Of per,μl
R14888 T19238 T19232 arg2Of day,at
R14889 T19238 T19235 arg1Of day,per
R14890 T19238 T19236 arg1Of day,well
R14891 T19238 T19237 arg1Of day,on
R14892 T19238 T19239 arg1Of day,of
R14893 T19240 T19239 arg2Of harvest,of
R14894 T19242 T19241 arg1Of and,","
R14895 T19243 T19244 arg1Of inhibitors,were
R14896 T19243 T19245 arg2Of inhibitors,added
R14897 T19245 T19242 arg2Of added,and
R14898 T19245 T19244 arg2Of added,were
R14899 T19245 T19246 arg1Of added,at
R14900 T19248 T19246 arg2Of concentrations,at
R14901 T19248 T19247 arg1Of concentrations,the
R14902 T19248 T19249 arg2Of concentrations,indicated
R14903 T19249 T19250 arg1Of indicated,in
R14904 T19252 T19250 arg2Of figures,in
R14905 T19252 T19251 arg1Of figures,the
R14906 T19255 T19256 arg1Of BAY11–7085,","
R14907 T19256 T19258 arg1Of ",",","
R14908 T19257 T19256 arg2Of rapamycin,","
R14909 T19258 T19260 arg1Of ",",","
R14910 T19259 T19258 arg2Of triciribine,","
R14911 T19260 T19262 arg1Of ",",","
R14912 T19261 T19260 arg2Of U0126,","
R14913 T19262 T19254 arg1Of ",",inhibitors
R14914 T19262 T19265 arg1Of ",",and
R14915 T19263 T19262 arg2Of SB202190,","
R14916 T19265 T19264 arg1Of and,","
R14917 T19265 T19277 arg1Of and,","
R14918 T19266 T19265 arg2Of cucurbitacin,and
R14919 T19266 T19268 modOf cucurbitacin,were
R14920 T19267 T19268 arg1Of I,were
R14921 T19267 T19269 arg2Of I,purchased
R14922 T19269 T19268 arg2Of purchased,were
R14923 T19269 T19270 arg1Of purchased,from
R14924 T19269 T19273 arg1Of purchased,For
R14925 T19272 T19270 arg2Of Biosciences.,from
R14926 T19272 T19271 arg1Of Biosciences.,EMD
R14927 T19276 T19273 arg2Of cultures,For
R14928 T19276 T19274 arg1Of cultures,non-malignant
R14929 T19276 T19275 arg1Of cultures,splenocyte
R14930 T19277 T19253 arg1Of ",",The
R14931 T19277 T19281 arg1Of ",",was
R14932 T19277 T19282 arg2Of ",",induced
R14933 T19280 T19277 arg2Of activation,","
R14934 T19280 T19278 arg1Of activation,B
R14935 T19280 T19279 arg1Of activation,cell
R14936 T19282 T19281 arg2Of induced,was
R14937 T19282 T19283 arg1Of induced,with
R14938 T19285 T19283 arg2Of μg/ml,with
R14939 T19285 T19284 arg1Of μg/ml,10
R14940 T19285 T19286 arg1Of μg/ml,of
R14941 T19290 T19289 arg2Of ab,(
R14942 T19290 T19291 arg1Of ab,'
R14943 T19292 T19289 arg3Of ),(
R14944 T19294 T19286 arg2Of IgM,of
R14945 T19294 T19287 arg1Of IgM,goat
R14946 T19294 T19288 arg1Of IgM,F
R14947 T19294 T19289 arg1Of IgM,(
R14948 T19294 T19293 arg1Of IgM,anti-mouse
R14949 T19294 T19295 arg1Of IgM,(
R14950 T19297 T19295 arg2Of ImmunoResearch,(
R14951 T19297 T19296 arg1Of ImmunoResearch,Jackson
R14952 T19298 T19295 arg3Of ),(
R14953 T19299 T19300 arg1Of Cultures,were
R14954 T19299 T19301 arg2Of Cultures,pulsed
R14955 T19301 T19300 arg2Of pulsed,were
R14956 T19301 T19302 arg1Of pulsed,for
R14957 T19304 T19302 arg2Of h,for
R14958 T19304 T19303 arg1Of h,4
R14959 T19304 T19305 arg1Of h,with
R14960 T19309 T19305 arg2Of d,with
R14961 T19309 T19306 arg1Of d,MTS
R14962 T19309 T19307 arg1Of d,reagent
R14963 T19309 T19308 arg1Of d,1
R14964 T19309 T19310 arg1Of d,post-seeding
R15243 T19653 T19651 arg1Of sections,Paraffin-embedded
R15244 T19653 T19652 arg1Of sections,spleen
R15245 T19653 T19654 arg1Of sections,were
R15246 T19653 T19655 arg2Of sections,deparaffinized
R15247 T19653 T19663 arg2Of sections,rehydrated
R15248 T19655 T19656 arg1Of deparaffinized,in
R15249 T19655 T19662 arg1Of deparaffinized,and
R15250 T19657 T19656 arg2Of Histoclear,in
R15251 T19657 T19658 arg1Of Histoclear,(
R15252 T19660 T19658 arg2Of Diagnostics,(
R15253 T19660 T19659 arg1Of Diagnostics,National
R15254 T19661 T19658 arg3Of ),(
R15255 T19662 T19654 arg2Of and,were
R15256 T19663 T19662 arg2Of rehydrated,and
R15257 T19663 T19664 arg1Of rehydrated,in
R15258 T19666 T19664 arg2Of ethanol,in
R15259 T19666 T19665 arg2Of ethanol,graded
R15260 T19667 T19668 arg1Of Sections,were
R15261 T19669 T19668 arg2Of antigen,were
R15262 T19669 T19670 arg2Of antigen,retrieved
R15263 T19670 T19671 arg1Of retrieved,by
R15264 T19672 T19671 arg2Of microwaving,by
R15265 T19672 T19673 arg1Of microwaving,in
R15266 T19672 T19680 arg1Of microwaving,for
R15267 T19675 T19673 arg2Of buffer,in
R15268 T19675 T19674 arg1Of buffer,citrate
R15269 T19675 T19676 arg1Of buffer,(
R15270 T19677 T19676 arg2Of pH,(
R15271 T19677 T19678 arg1Of pH,6.0
R15272 T19679 T19676 arg3Of ),(
R15273 T19682 T19681 arg1Of min,15
R15274 T19682 T19683 arg1Of min,(
R15275 T19682 T19687 arg1Of min,and
R15276 T19685 T19683 arg2Of staining,(
R15277 T19685 T19684 arg1Of staining,LMP1
R15278 T19686 T19683 arg3Of ),(
R15279 T19687 T19680 arg2Of and,for
R15280 T19689 T19687 arg2Of min,and
R15281 T19689 T19688 arg1Of min,10
R15282 T19689 T19690 arg1Of min,(
R15283 T19692 T19690 arg2Of staining,(
R15284 T19692 T19691 arg1Of staining,pStat3
R15285 T19693 T19690 arg3Of ),(
R15286 T19696 T19694 arg2Of staining,For
R15287 T19696 T19695 arg1Of staining,LMP1
R15288 T19698 T19699 arg1Of sections,were
R15289 T19698 T19700 arg2Of sections,blocked
R15290 T19700 T19694 arg1Of blocked,For
R15291 T19700 T19697 arg1Of blocked,","
R15292 T19700 T19699 arg2Of blocked,were
R15293 T19700 T19701 arg1Of blocked,with
R15294 T19704 T19702 arg1Of BSA,1
R15295 T19704 T19703 arg1Of BSA,%
R15296 T19704 T19705 arg1Of BSA,and
R15297 T19705 T19701 arg2Of and,with
R15298 T19705 T19712 arg2Of and,followed
R15299 T19706 T19707 arg1Of 0.1,%
R15300 T19711 T19705 arg2Of gelatin,and
R15301 T19711 T19706 arg1Of gelatin,0.1
R15302 T19711 T19708 arg1Of gelatin,cold
R15303 T19711 T19709 arg1Of gelatin,fish
R15304 T19711 T19710 arg1Of gelatin,skin
R15305 T19712 T19713 arg1Of followed,with
R15306 T19715 T19713 arg2Of block,with
R15307 T19715 T19714 arg1Of block,streptavidin/biotin
R15308 T19715 T19716 arg1Of block,(
R15309 T19718 T19716 arg2Of Labs,(
R15310 T19718 T19717 arg1Of Labs,Vector
R15311 T19719 T19716 arg3Of ),(
R15312 T19722 T19720 arg1Of anti-LMP1,Rat
R15313 T19722 T19721 arg1Of anti-LMP1,IgG
R15314 T19722 T19723 arg1Of anti-LMP1,(
R15315 T19722 T19731 arg1Of anti-LMP1,were
R15316 T19722 T19732 arg2Of anti-LMP1,used
R15317 T19725 T19726 arg1Of 8G3,and
R15318 T19726 T19723 arg2Of and,(
R15319 T19726 T19724 arg1Of and,clones
R15320 T19726 T19728 arg1Of and,","
R15321 T19727 T19726 arg2Of 1G6,and
R15322 T19729 T19728 arg2Of Ascenion,","
R15323 T19730 T19723 arg3Of ),(
R15324 T19732 T19731 arg2Of used,were
R15325 T19732 T19733 arg1Of used,at
R15326 T19732 T19738 arg1Of used,from
R15327 T19732 T19742 arg1Of used,","
R15328 T19732 T19743 modOf used,followed
R15329 T19736 T19735 arg1Of 10,:
R15330 T19737 T19733 arg2Of dilution,at
R15331 T19737 T19734 arg1Of dilution,1
R15332 T19737 T19736 arg1Of dilution,10
R15333 T19741 T19738 arg2Of supernatants,from
R15334 T19741 T19739 arg1Of supernatants,tissue
R15335 T19741 T19740 arg1Of supernatants,culture
R15336 T19743 T19744 arg1Of followed,with
R15337 T19743 T19755 arg1Of followed,IgG
R15338 T19747 T19746 arg1Of biotinylated,μg/ml
R15339 T19749 T19744 arg2Of F,with
R15340 T19749 T19745 arg1Of F,8
R15341 T19749 T19747 arg1Of F,biotinylated
R15342 T19749 T19748 arg1Of F,mouse
R15343 T19751 T19750 arg2Of ab,(
R15344 T19751 T19752 arg1Of ab,'
R15345 T19753 T19750 arg3Of ),(
R15346 T19755 T19750 arg1Of IgG,(
R15347 T19755 T19754 arg1Of IgG,anti-rat
R15348 T19755 T19759 arg1Of IgG,pre-adsorbed
R15349 T19757 T19756 arg2Of H+L,(
R15350 T19758 T19756 arg3Of ),(
R15351 T19759 T19756 arg1Of pre-adsorbed,(
R15352 T19759 T19760 arg1Of pre-adsorbed,to
R15353 T19762 T19761 arg1Of serum,mouse
R15354 T19762 T19763 arg1Of serum,(
R15355 T19762 T19767 arg1Of serum,and
R15356 T19765 T19763 arg2Of ImmunoResearch,(
R15357 T19765 T19764 arg1Of ImmunoResearch,Jackson
R15358 T19766 T19763 arg3Of ),(
R15359 T19767 T19760 arg2Of and,to
R15360 T19772 T19767 arg2Of conjugate,and
R15361 T19772 T19768 arg1Of conjugate,2
R15362 T19772 T19769 arg1Of conjugate,μg/ml
R15363 T19772 T19770 arg1Of conjugate,streptavidin-alkaline
R15364 T19772 T19771 arg1Of conjugate,phosphatase
R15365 T19772 T19773 arg1Of conjugate,(
R15366 T19775 T19773 arg2Of ImmunoResearch,(
R15367 T19775 T19774 arg1Of ImmunoResearch,Jackson
R15368 T19776 T19773 arg3Of ),(
R15369 T19777 T19778 arg1Of Stains,were
R15370 T19777 T19779 arg2Of Stains,developed
R15371 T19777 T19783 arg2Of Stains,counterstained
R15372 T19779 T19780 arg1Of developed,with
R15373 T19779 T19782 arg1Of developed,and
R15374 T19781 T19780 arg2Of BCIP/NBT,with
R15375 T19782 T19778 arg2Of and,were
R15376 T19783 T19782 arg2Of counterstained,and
R15377 T19783 T19784 arg1Of counterstained,in
R15378 T19787 T19784 arg2Of Red,in
R15379 T19787 T19785 arg1Of Red,Nuclear
R15380 T19787 T19786 arg1Of Red,Fast
R15381 T19787 T19788 arg1Of Red,(
R15382 T19789 T19788 arg2Of Dako,(
R15383 T19790 T19788 arg3Of ),(
R15384 T19791 T19792 arg1Of Phospho-Stat3,was
R15385 T19791 T19793 arg2Of Phospho-Stat3,detected
R15386 T19791 T19807 arg2Of Phospho-Stat3,detected
R15387 T19793 T19794 arg1Of detected,with
R15388 T19793 T19806 arg1Of detected,and
R15389 T19796 T19794 arg2Of μg/ml,with
R15390 T19796 T19795 arg1Of μg/ml,4
R15391 T19796 T19797 arg1Of μg/ml,of
R15392 T19796 T19800 arg1Of μg/ml,(
R15393 T19799 T19797 arg2Of antibody,of
R15394 T19799 T19798 arg1Of antibody,pStat3
R15395 T19801 T19800 arg2Of Tyr705,(
R15396 T19801 T19802 arg1Of Tyr705,","
R15397 T19804 T19802 arg2Of Signaling,","
R15398 T19804 T19803 arg1Of Signaling,Cell
R15399 T19805 T19800 arg3Of ),(
R15400 T19806 T19792 arg2Of and,was
R15401 T19806 T19814 arg1Of and,(
R15402 T19807 T19806 arg2Of detected,and
R15403 T19807 T19808 arg1Of detected,with
R15404 T19813 T19808 arg2Of kit,with
R15405 T19813 T19809 arg1Of kit,anti-rabbit
R15406 T19813 T19810 arg1Of kit,Poly-HRP
R15407 T19813 T19811 arg1Of kit,IHC
R15408 T19813 T19812 arg1Of kit,detection
R15409 T19815 T19814 arg2Of Chemicon,(
R15410 T19816 T19814 arg3Of ),(
R15589 T20046 T20045 arg1Of cytometry,Flow
R15590 T20048 T20047 arg1Of million,One
R15591 T20049 T20048 arg1Of splenocytes,million
R15592 T20049 T20050 arg1Of splenocytes,were
R15593 T20049 T20051 arg2Of splenocytes,stained
R15594 T20049 T20059 arg2Of splenocytes,conjugated
R15595 T20051 T20052 arg1Of stained,with
R15596 T20051 T20058 arg1Of stained,or
R15597 T20056 T20052 arg2Of antibody,with
R15598 T20056 T20053 arg1Of antibody,the
R15599 T20056 T20054 arg1Of antibody,appropriate
R15600 T20056 T20055 arg1Of antibody,primary
R15601 T20056 T20057 arg1Of antibody,unconjugated
R15602 T20058 T20050 arg2Of or,were
R15603 T20059 T20058 arg2Of conjugated,or
R15604 T20059 T20060 arg1Of conjugated,to
R15605 T20061 T20062 arg1Of FITC,","
R15606 T20062 T20065 arg1Of ",",or
R15607 T20063 T20062 arg2Of PE,","
R15608 T20065 T20060 arg2Of or,to
R15609 T20065 T20064 arg1Of or,","
R15610 T20065 T20067 arg2Of or,diluted
R15611 T20066 T20065 arg2Of APC,or
R15612 T20067 T20068 arg1Of diluted,in
R15613 T20070 T20068 arg2Of buffer,in
R15614 T20070 T20069 arg1Of buffer,stain
R15615 T20070 T20071 arg1Of buffer,(
R15616 T20072 T20071 arg2Of PBS,(
R15617 T20072 T20073 arg1Of PBS,with
R15618 T20074 T20075 arg1Of 3,%
R15619 T20076 T20073 arg2Of FBS,with
R15620 T20076 T20074 arg1Of FBS,3
R15621 T20077 T20071 arg3Of ),(
R15622 T20080 T20078 arg2Of detection,For
R15623 T20080 T20079 arg1Of detection,BrdU
R15624 T20085 T20082 arg1Of kit,the
R15625 T20085 T20083 arg1Of kit,FITC-BrdU
R15626 T20085 T20084 arg1Of kit,flow
R15627 T20085 T20086 arg1Of kit,was
R15628 T20085 T20087 arg2Of kit,used
R15629 T20087 T20078 arg1Of used,For
R15630 T20087 T20081 arg1Of used,","
R15631 T20087 T20086 arg2Of used,was
R15632 T20087 T20088 arg1Of used,as
R15633 T20089 T20088 arg2Of instructed,as
R15634 T20092 T20089 arg1Of manufacturer,instructed
R15635 T20092 T20090 arg2Of manufacturer,by
R15636 T20092 T20091 arg1Of manufacturer,the
R15637 T20092 T20093 arg1Of manufacturer,(
R15638 T20095 T20093 arg2Of Bioscience,(
R15639 T20095 T20094 arg1Of Bioscience,BD
R15640 T20096 T20093 arg3Of ),(
R15641 T20099 T20100 arg1Of cells,were
R15642 T20099 T20101 arg2Of cells,exposed
R15643 T20099 T20124 arg2Of cells,permeabilized
R15644 T20101 T20102 arg1Of exposed,to
R15645 T20101 T20123 arg1Of exposed,and
R15646 T20103 T20102 arg2Of EMA,to
R15647 T20103 T20104 arg1Of EMA,(
R15648 T20103 T20108 arg1Of EMA,for
R15649 T20106 T20104 arg2Of Probes,(
R15650 T20106 T20105 arg1Of Probes,Molecular
R15651 T20107 T20104 arg3Of ),(
R15652 T20109 T20108 arg2Of exclusion,for
R15653 T20109 T20110 arg1Of exclusion,of
R15654 T20109 T20113 arg1Of exclusion,","
R15655 T20109 T20114 arg2Of exclusion,stained
R15656 T20109 T20118 arg1Of exclusion,","
R15657 T20109 T20119 arg2Of exclusion,fixed
R15658 T20112 T20110 arg2Of cells,of
R15659 T20112 T20111 arg1Of cells,dead
R15660 T20114 T20115 arg1Of stained,for
R15661 T20117 T20115 arg2Of antigens,for
R15662 T20117 T20116 arg1Of antigens,surface
R15663 T20119 T20120 arg1Of fixed,in
R15664 T20121 T20120 arg2Of paraformaldehyde,in
R15665 T20123 T20097 arg1Of and,Briefly
R15666 T20123 T20098 arg1Of and,","
R15667 T20123 T20100 arg2Of and,were
R15668 T20123 T20122 arg1Of and,","
R15669 T20124 T20123 arg2Of permeabilized,and
R15670 T20124 T20125 arg1Of permeabilized,with
R15671 T20126 T20125 arg2Of saponin,with
R15672 T20128 T20127 arg1Of expose,To
R15673 T20130 T20128 arg2Of epitopes,expose
R15674 T20130 T20129 arg1Of epitopes,BrdU
R15675 T20132 T20128 arg1Of cells,expose
R15676 T20132 T20133 arg1Of cells,were
R15677 T20132 T20134 arg2Of cells,treated
R15678 T20132 T20138 arg2Of cells,stained
R15679 T20134 T20135 arg1Of treated,with
R15680 T20134 T20137 arg1Of treated,and
R15681 T20136 T20135 arg2Of Dnase,with
R15682 T20137 T20127 modOf and,To
R15683 T20137 T20131 arg1Of and,","
R15684 T20137 T20133 arg2Of and,were
R15685 T20138 T20137 arg2Of stained,and
R15686 T20138 T20139 arg1Of stained,with
R15687 T20142 T20139 arg2Of antibody,with
R15688 T20142 T20140 arg1Of antibody,FITC-conjugated
R15689 T20142 T20141 arg1Of antibody,anti-BrdU
R15690 T20144 T20143 arg1Of cytometry,Flow
R15691 T20144 T20145 arg1Of cytometry,was
R15692 T20144 T20146 arg2Of cytometry,performed
R15693 T20146 T20145 arg2Of performed,was
R15694 T20146 T20147 arg1Of performed,on
R15695 T20148 T20147 arg2Of FACScalibur,on
R15696 T20149 T20146 arg3Of using,performed
R15697 T20152 T20149 arg2Of program,using
R15698 T20152 T20150 arg1Of program,the
R15699 T20152 T20151 arg1Of program,CellQuest
R15700 T20152 T20153 arg1Of program,(
R15701 T20155 T20153 arg2Of Dickinson,(
R15702 T20155 T20154 arg1Of Dickinson,Becton
R15703 T20156 T20153 arg3Of ),(
R15704 T20158 T20157 arg1Of analysis,Further
R15705 T20158 T20159 arg1Of analysis,was
R15706 T20158 T20160 arg2Of analysis,conducted
R15707 T20160 T20159 arg2Of conducted,was
R15708 T20160 T20161 arg1Of conducted,on
R15709 T20165 T20161 arg2Of program,on
R15710 T20165 T20162 arg1Of program,the
R15711 T20165 T20163 arg1Of program,Summit
R15712 T20165 T20164 arg1Of program,v4.2
R15713 T20165 T20166 arg1Of program,(
R15714 T20167 T20166 arg2Of Dako,(
R15715 T20168 T20166 arg3Of ),(
R15849 T20346 T20344 arg1Of assay,Rnase
R15850 T20346 T20345 arg1Of assay,protection
R15851 T20348 T20347 arg1Of RNA,Total
R15852 T20348 T20349 arg1Of RNA,was
R15853 T20348 T20350 arg2Of RNA,isolated
R15854 T20350 T20349 arg2Of isolated,was
R15855 T20350 T20351 arg1Of isolated,from
R15856 T20350 T20365 arg1Of isolated,","
R15857 T20350 T20366 arg1Of isolated,according
R15858 T20355 T20351 arg2Of cells,from
R15859 T20355 T20352 arg1Of cells,CD19+
R15860 T20355 T20353 arg1Of cells,MACS-purified
R15861 T20355 T20354 arg1Of cells,B
R15862 T20355 T20356 arg1Of cells,using
R15863 T20361 T20356 arg2Of kit,using
R15864 T20361 T20357 arg1Of kit,the
R15865 T20361 T20358 arg1Of kit,Rneasy
R15866 T20361 T20359 arg1Of kit,midi
R15867 T20361 T20360 arg1Of kit,purification
R15868 T20361 T20362 arg1Of kit,with
R15869 T20364 T20362 arg2Of treatment,with
R15870 T20364 T20363 arg1Of treatment,Dnase
R15871 T20367 T20366 arg2Of to,according
R15872 T20369 T20368 arg1Of manufacturer,the
R15873 T20369 T20370 arg2Of manufacturer,'s
R15874 T20371 T20367 arg2Of instructions,to
R15875 T20371 T20370 arg1Of instructions,'s
R15876 T20371 T20372 arg1Of instructions,(
R15877 T20373 T20372 arg2Of Qiagen,(
R15878 T20374 T20372 arg3Of ),(
R15879 T20379 T20375 arg1Of set,The
R15880 T20379 T20376 arg1Of set,mCK-1
R15881 T20379 T20377 arg1Of set,probe
R15882 T20379 T20378 arg1Of set,template
R15883 T20379 T20380 arg1Of set,(
R15884 T20379 T20384 arg1Of set,was
R15885 T20379 T20385 arg2Of set,labeled
R15886 T20382 T20380 arg2Of Biosciences,(
R15887 T20382 T20381 arg1Of Biosciences,BD
R15888 T20383 T20380 arg3Of ),(
R15889 T20385 T20384 arg2Of labeled,was
R15890 T20385 T20386 modOf labeled,using
R15891 T20386 T20392 arg1Of using,according
R15892 T20389 T20388 arg1Of Vitro,In
R15893 T20391 T20386 arg2Of Kit,using
R15894 T20391 T20387 arg1Of Kit,the
R15895 T20391 T20389 arg1Of Kit,Vitro
R15896 T20391 T20390 arg1Of Kit,Transcription
R15897 T20393 T20392 arg2Of to,according
R15898 T20395 T20394 arg1Of manufacturer,the
R15899 T20395 T20396 arg2Of manufacturer,'s
R15900 T20397 T20393 arg2Of instructions,to
R15901 T20397 T20396 arg1Of instructions,'s
R15902 T20397 T20398 arg1Of instructions,(
R15903 T20400 T20398 arg2Of Biosciences,(
R15904 T20400 T20399 arg1Of Biosciences,BD
R15905 T20401 T20398 arg3Of ),(
R15906 T20405 T20404 arg1Of ng,50
R15907 T20405 T20406 arg1Of ng,of
R15908 T20405 T20410 arg1Of ng,was
R15909 T20405 T20411 arg2Of ng,labeled
R15910 T20409 T20406 arg2Of set,of
R15911 T20409 T20407 arg1Of set,mCK-1
R15912 T20409 T20408 arg1Of set,probe
R15913 T20411 T20402 arg1Of labeled,Briefly
R15914 T20411 T20403 arg1Of labeled,","
R15915 T20411 T20410 arg2Of labeled,was
R15916 T20411 T20412 arg1Of labeled,with
R15917 T20414 T20413 arg2Of α-32P,[
R15918 T20415 T20413 arg3Of ],[
R15919 T20416 T20412 arg2Of UTP,with
R15920 T20416 T20413 arg1Of UTP,[
R15921 T20416 T20417 arg1Of UTP,using
R15922 T20416 T20422 arg2Of UTP,purified
R15923 T20417 T20421 arg1Of using,and
R15924 T20420 T20417 arg2Of polymerase,using
R15925 T20420 T20418 arg1Of polymerase,T7
R15926 T20420 T20419 arg1Of polymerase,RNA
R15927 T20422 T20421 arg2Of purified,and
R15928 T20422 T20423 modOf purified,using
R15929 T20426 T20423 arg2Of columns,using
R15930 T20426 T20424 arg1Of columns,Sephadex
R15931 T20426 T20425 arg1Of columns,G-50
R15932 T20426 T20427 arg1Of columns,(
R15933 T20429 T20428 arg1Of Spin,NucAway
R15934 T20430 T20427 arg2Of column,(
R15935 T20430 T20429 arg1Of column,Spin
R15936 T20430 T20431 arg1Of column,","
R15937 T20432 T20431 arg2Of Ambion,","
R15938 T20433 T20427 arg3Of ),(
R15939 T20436 T20434 arg1Of probe,The
R15940 T20436 T20435 arg2Of probe,labeled
R15941 T20436 T20437 arg1Of probe,was
R15942 T20436 T20438 arg2Of probe,quantitated
R15943 T20436 T20439 arg1Of probe,using
R15944 T20438 T20437 arg2Of quantitated,was
R15945 T20438 T20444 arg1Of quantitated,and
R15946 T20439 T20438 arg3Of using,quantitated
R15947 T20442 T20439 arg2Of counter,using
R15948 T20442 T20440 arg1Of counter,a
R15949 T20442 T20441 arg1Of counter,scintillation
R15950 T20444 T20443 arg1Of and,","
R15951 T20447 T20446 arg1Of 105,×
R15952 T20449 T20445 arg1Of cpm,6
R15953 T20449 T20447 arg1Of cpm,105
R15954 T20449 T20448 arg1Of cpm,cherenkov
R15955 T20449 T20450 arg1Of cpm,was
R15956 T20449 T20451 arg2Of cpm,used
R15957 T20449 T20453 arg1Of cpm,hybridize
R15958 T20451 T20444 arg2Of used,and
R15959 T20451 T20450 arg2Of used,was
R15960 T20453 T20451 arg3Of hybridize,used
R15961 T20453 T20452 arg1Of hybridize,to
R15962 T20453 T20454 arg1Of hybridize,to
R15963 T20456 T20454 arg2Of μg,to
R15964 T20456 T20455 arg1Of μg,4
R15965 T20456 T20457 arg1Of μg,of
R15966 T20459 T20457 arg2Of RNA,of
R15967 T20459 T20458 arg1Of RNA,total
R15968 T20459 T20460 arg1Of RNA,using
R15969 T20463 T20460 arg2Of kit,using
R15970 T20463 T20461 arg1Of kit,the
R15971 T20463 T20462 arg1Of kit,RPA
R15972 T20463 T20464 arg1Of kit,(
R15973 T20466 T20464 arg2Of Biosciences,(
R15974 T20466 T20465 arg1Of Biosciences,BD
R15975 T20467 T20464 arg3Of ),(
R15976 T20468 T20469 arg1Of Samples,were
R15977 T20468 T20470 arg2Of Samples,denatured
R15978 T20468 T20475 arg1Of Samples,hybridized
R15979 T20470 T20469 arg2Of denatured,were
R15980 T20470 T20471 arg1Of denatured,at
R15981 T20470 T20474 arg1Of denatured,and
R15982 T20473 T20471 arg2Of °C,at
R15983 T20473 T20472 arg1Of °C,90
R15984 T20475 T20474 arg2Of hybridized,and
R15985 T20475 T20476 arg1Of hybridized,at
R15986 T20478 T20476 arg2Of °C,at
R15987 T20478 T20477 arg1Of °C,56
R15988 T20478 T20479 arg1Of °C,overnight
R15989 T20481 T20480 arg1Of RNA,Single-stranded
R15990 T20481 T20482 arg1Of RNA,was
R15991 T20481 T20483 arg2Of RNA,digested
R15992 T20481 T20494 arg2Of RNA,precipitated
R15993 T20481 T20495 arg1Of RNA,using
R15994 T20483 T20484 arg1Of digested,with
R15995 T20483 T20493 arg1Of digested,and
R15996 T20486 T20484 arg2Of mixture,with
R15997 T20486 T20485 arg1Of mixture,a
R15998 T20486 T20487 arg1Of mixture,of
R15999 T20489 T20488 arg1Of A,Rnase
R16000 T20489 T20490 arg1Of A,and
R16001 T20490 T20487 arg2Of and,of
R16002 T20491 T20490 arg2Of T1,and
R16003 T20493 T20482 arg2Of and,was
R16004 T20493 T20492 arg1Of and,","
R16005 T20494 T20493 arg2Of precipitated,and
R16006 T20495 T20494 arg3Of using,precipitated
R16007 T20496 T20495 arg2Of isopropanol,using
R16008 T20498 T20497 arg2Of probes,Protected
R16009 T20498 T20499 arg1Of probes,were
R16010 T20498 T20500 arg2Of probes,resolved
R16011 T20498 T20512 arg2Of probes,imaged
R16012 T20498 T20513 arg1Of probes,using
R16013 T20500 T20501 arg1Of resolved,on
R16014 T20500 T20511 arg1Of resolved,and
R16015 T20504 T20505 arg1Of 4.75,%
R16016 T20507 T20501 arg2Of gel,on
R16017 T20507 T20502 arg1Of gel,a
R16018 T20507 T20503 arg1Of gel,denaturing
R16019 T20507 T20504 arg1Of gel,4.75
R16020 T20507 T20506 arg1Of gel,acrylamide
R16021 T20507 T20508 arg1Of gel,","
R16022 T20507 T20509 arg2Of gel,dried
R16023 T20511 T20499 arg2Of and,were
R16024 T20511 T20510 arg1Of and,","
R16025 T20512 T20511 arg2Of imaged,and
R16026 T20513 T20512 arg3Of using,imaged
R16027 T20515 T20513 arg2Of phosphorImager,using
R16028 T20515 T20514 arg1Of phosphorImager,a
R16029 T20515 T20516 arg1Of phosphorImager,(
R16030 T20518 T20516 arg2Of Dynamics,(
R16031 T20518 T20517 arg1Of Dynamics,Molecular
R16032 T20519 T20516 arg3Of ),(
R16033 T20520 T20521 arg1Of Densitometry,was
R16034 T20520 T20522 arg2Of Densitometry,performed
R16035 T20522 T20521 arg2Of performed,was
R16036 T20523 T20522 arg3Of using,performed
R16037 T20528 T20523 arg2Of software,using
R16038 T20528 T20524 arg1Of software,the
R16039 T20528 T20525 arg1Of software,ImageQuant
R16040 T20528 T20526 arg1Of software,TL
R16041 T20528 T20527 arg1Of software,v2005
R16042 T20528 T20529 arg1Of software,(
R16043 T20531 T20529 arg2Of Healthcare,(
R16044 T20531 T20530 arg1Of Healthcare,GE
R16045 T20532 T20529 arg3Of ),(
R16247 T20774 T20773 arg1Of analysis,PCR
R16248 T20774 T20775 arg1Of analysis,of
R16249 T20778 T20775 arg2Of rearrangement,of
R16250 T20778 T20776 arg1Of rearrangement,κ
R16251 T20778 T20777 arg1Of rearrangement,chain
R16252 T20779 T20780 arg1Of DNA,was
R16253 T20779 T20781 arg2Of DNA,isolated
R16254 T20781 T20780 arg2Of isolated,was
R16255 T20781 T20782 arg1Of isolated,from
R16256 T20781 T20792 arg1Of isolated,","
R16257 T20781 T20793 arg1Of isolated,with
R16258 T20783 T20782 arg2Of splenocytes,from
R16259 T20783 T20784 arg1Of splenocytes,using
R16260 T20788 T20784 arg2Of Kit,using
R16261 T20788 T20785 arg1Of Kit,the
R16262 T20788 T20786 arg1Of Kit,Dneasy
R16263 T20788 T20787 arg1Of Kit,Tissue
R16264 T20788 T20789 arg1Of Kit,(
R16265 T20790 T20789 arg2Of Qiagen,(
R16266 T20791 T20789 arg3Of ),(
R16267 T20795 T20793 arg2Of treatment,with
R16268 T20795 T20794 arg1Of treatment,Rnase
R16269 T20797 T20796 arg1Of reactions,PCR
R16270 T20797 T20798 arg1Of reactions,contained
R16271 T20800 T20798 arg2Of ng,contained
R16272 T20800 T20799 arg1Of ng,100
R16273 T20800 T20801 arg1Of ng,of
R16274 T20803 T20802 arg1Of DNA,genomic
R16275 T20803 T20804 arg1Of DNA,","
R16276 T20804 T20809 arg1Of ",",","
R16277 T20806 T20804 arg2Of μM,","
R16278 T20806 T20805 arg1Of μM,0.2
R16279 T20806 T20808 arg1Of μM,primer
R16280 T20808 T20807 arg1Of primer,each
R16281 T20809 T20814 arg1Of ",",and
R16282 T20812 T20809 arg2Of dNTPs,","
R16283 T20812 T20810 arg1Of dNTPs,0.2
R16284 T20812 T20811 arg1Of dNTPs,mM
R16285 T20814 T20801 arg2Of and,of
R16286 T20814 T20813 arg1Of and,","
R16287 T20814 T20823 arg2Of and,performed
R16288 T20815 T20816 arg1Of 2.5,U
R16289 T20819 T20814 arg2Of polymerase,and
R16290 T20819 T20815 arg1Of polymerase,2.5
R16291 T20819 T20817 arg1Of polymerase,Taq
R16292 T20819 T20818 arg1Of polymerase,DNA
R16293 T20819 T20820 arg1Of polymerase,(
R16294 T20821 T20820 arg2Of NEB,(
R16295 T20822 T20820 arg3Of ),(
R16296 T20823 T20824 arg1Of performed,in
R16297 T20827 T20824 arg2Of buffer,in
R16298 T20827 T20825 arg1Of buffer,1X
R16299 T20827 T20826 arg1Of buffer,ThermoPol
R16300 T20827 T20828 arg1Of buffer,(
R16301 T20829 T20828 arg2Of NEB,(
R16302 T20830 T20828 arg3Of ),(
R16303 T20831 T20832 arg2Of Primers,used
R16304 T20831 T20833 arg1Of Primers,were
R16305 T20831 T20838 arg1Of Primers,have
R16306 T20831 T20839 arg1Of Primers,been
R16307 T20831 T20840 arg2Of Primers,described
R16308 T20833 T20837 arg1Of were,and
R16309 T20834 T20835 arg1Of Vκcon,and
R16310 T20835 T20833 arg2Of and,were
R16311 T20836 T20835 arg2Of Jκ5–1°,and
R16312 T20840 T20837 arg2Of described,and
R16313 T20840 T20838 arg2Of described,have
R16314 T20840 T20839 arg2Of described,been
R16315 T20840 T20841 arg1Of described,previously
R16316 T20840 T20842 arg1Of described,[
R16317 T20843 T20842 arg2Of 74,[
R16318 T20844 T20842 arg3Of ],[
R16319 T20846 T20845 arg1Of conditions,PCR
R16320 T20846 T20847 arg1Of conditions,were
R16321 T20847 T20850 arg1Of were,for
R16324 T20849 T20847 arg2Of °C,were
R16325 T20849 T20848 arg1Of °C,94
R16326 T20852 T20851 arg1Of min,2
R16327 T20852 T20853 arg1Of min,","
R16329 T20855 T20853 arg2Of cycles,","
R16330 T20855 T20854 arg1Of cycles,40
R16331 T20855 T20856 arg1Of cycles,of
R16332 T20858 T20856 arg2Of °C,of
R16333 T20858 T20857 arg1Of °C,94
R16343 T20869 T20850 arg2Of and,for
R16484 T21035 T21034 arg1Of analysis,Immunoblot
R16485 T21038 T21036 arg1Of lysates,Whole
R16486 T21038 T21037 arg1Of lysates,cell
R16487 T21038 T21039 arg1Of lysates,were
R16488 T21038 T21040 arg2Of lysates,prepared
R16489 T21040 T21039 arg2Of prepared,were
R16490 T21040 T21041 arg1Of prepared,in
R16491 T21040 T21047 arg1Of prepared,buffer
R16494 T21043 T21041 arg2Of assay,in
R16495 T21045 T21044 arg2Of RIPA,(
R16496 T21046 T21044 arg3Of ),(
R16497 T21047 T21048 arg1Of buffer,(
R16498 T21047 T21078 arg2Of buffer,supplemented
R16499 T21049 T21050 arg1Of 20,mM
R16500 T21051 T21049 arg1Of Tris-HCl,20
R16501 T21051 T21052 arg1Of Tris-HCl,[
R16502 T21051 T21056 arg1Of Tris-HCl,","
R16503 T21053 T21052 arg2Of pH,[
R16504 T21053 T21054 arg1Of pH,7.5
R16505 T21055 T21052 arg3Of ],[
R16506 T21056 T21048 arg2Of ",",(
R16507 T21057 T21058 arg1Of 150,mM
R16508 T21059 T21057 arg1Of NaCl,150
R16509 T21059 T21060 arg1Of NaCl,","
R16510 T21060 T21064 arg1Of ",",","
R16511 T21061 T21062 arg1Of 1,mM
R16512 T21063 T21060 arg2Of EDTA,","
R16513 T21063 T21061 arg1Of EDTA,1
R16514 T21064 T21068 arg1Of ",",","
R16515 T21065 T21066 arg1Of 1,%
R16516 T21067 T21064 arg2Of NP-40,","
R16517 T21067 T21065 arg1Of NP-40,1
R16518 T21068 T21072 arg1Of ",",","
R16519 T21069 T21070 arg1Of 0.1,%
R16520 T21071 T21068 arg2Of SDS,","
R16521 T21071 T21069 arg1Of SDS,0.1
R16522 T21072 T21056 arg2Of ",",","
R16523 T21073 T21074 arg1Of 0.1,%
R16524 T21076 T21072 arg2Of deoxycholate,","
R16525 T21076 T21073 arg1Of deoxycholate,0.1
R16526 T21076 T21075 arg1Of deoxycholate,sodium
R16527 T21077 T21048 arg3Of ),(
R16528 T21078 T21079 arg1Of supplemented,with
R16529 T21080 T21081 arg1Of 2,mM
R16530 T21083 T21080 arg1Of fluoride,2
R16531 T21083 T21082 arg1Of fluoride,phenylmethylsulfonyl
R16532 T21083 T21084 arg1Of fluoride,","
R16533 T21084 T21089 arg1Of ",",and
R16534 T21085 T21086 arg1Of 1,mM
R16535 T21087 T21084 arg2Of Na3VO4,","
R16536 T21087 T21085 arg1Of Na3VO4,1
R16537 T21089 T21079 arg2Of and,with
R16538 T21089 T21088 arg1Of and,","
R16539 T21092 T21090 arg1Of 100,1
R16540 T21092 T21091 arg1Of 100,:
R16541 T21095 T21089 arg2Of cocktails,and
R16542 T21095 T21092 arg1Of cocktails,100
R16543 T21095 T21093 arg1Of cocktails,protease/phosphatase
R16544 T21095 T21094 arg1Of cocktails,inhibitor
R16545 T21095 T21096 arg1Of cocktails,(
R16546 T21097 T21096 arg2Of Sigma,(
R16547 T21098 T21096 arg3Of ),(
R16548 T21100 T21099 arg1Of lysates,Crude
R16549 T21100 T21101 arg1Of lysates,were
R16550 T21100 T21102 arg2Of lysates,centrifuged
R16551 T21102 T21101 arg2Of centrifuged,were
R16552 T21102 T21103 arg1Of centrifuged,at
R16553 T21102 T21106 arg1Of centrifuged,for
R16554 T21102 T21109 arg1Of centrifuged,at
R16555 T21102 T21112 arg1Of centrifuged,and
R16556 T21105 T21103 arg2Of rpm,at
R16557 T21105 T21104 arg1Of rpm,"13,000"
R16558 T21108 T21106 arg2Of min,for
R16559 T21108 T21107 arg1Of min,10
R16560 T21111 T21109 arg2Of °C,at
R16561 T21111 T21110 arg1Of °C,4
R16562 T21114 T21113 arg1Of supernatants,the
R16563 T21114 T21115 arg1Of supernatants,were
R16564 T21114 T21116 arg2Of supernatants,collected
R16565 T21116 T21112 arg2Of collected,and
R16566 T21116 T21115 arg2Of collected,were
R16567 T21116 T21117 arg1Of collected,for
R16568 T21119 T21117 arg2Of analysis,for
R16569 T21119 T21118 arg1Of analysis,further
R16570 T21121 T21120 arg1Of concentrations,Protein
R16571 T21121 T21122 arg1Of concentrations,were
R16572 T21121 T21123 arg2Of concentrations,determined
R16573 T21123 T21122 arg2Of determined,were
R16574 T21123 T21124 arg1Of determined,with
R16575 T21130 T21124 arg2Of system,with
R16576 T21130 T21125 arg1Of system,the
R16577 T21130 T21126 arg1Of system,Bio-Rad
R16578 T21130 T21127 arg1Of system,DC
R16579 T21130 T21128 arg1Of system,protein
R16580 T21130 T21129 arg1Of system,assay
R16581 T21131 T21132 arg1Of Lysates,were
R16582 T21131 T21133 arg2Of Lysates,boiled
R16583 T21131 T21148 arg2Of Lysates,transferred
R16584 T21133 T21134 arg1Of boiled,in
R16585 T21133 T21147 arg1Of boiled,and
R16586 T21136 T21134 arg2Of presence,in
R16587 T21136 T21135 arg1Of presence,the
R16588 T21136 T21137 arg1Of presence,of
R16589 T21136 T21141 arg1Of presence,","
R16590 T21136 T21142 arg2Of presence,separated
R16591 T21138 T21139 arg1Of 2.5,%
R16592 T21140 T21137 arg2Of β-mecaptoethanol,of
R16593 T21140 T21138 arg1Of β-mecaptoethanol,2.5
R16594 T21145 T21142 arg1Of SDS-PAGE,separated
R16595 T21145 T21143 arg2Of SDS-PAGE,by
R16596 T21145 T21144 arg1Of SDS-PAGE,denaturing
R16597 T21147 T21132 arg2Of and,were
R16598 T21147 T21146 arg1Of and,","
R16599 T21148 T21147 arg2Of transferred,and
R16600 T21148 T21149 arg1Of transferred,to
R16601 T21148 T21153 arg1Of transferred,(
R16602 T21148 T21158 arg1Of transferred,in
R16603 T21152 T21149 arg2Of membranes,to
R16604 T21152 T21150 arg1Of membranes,0.45-μm
R16605 T21152 T21151 arg1Of membranes,Optitran
R16606 T21156 T21153 arg2Of Schuell,(
R16607 T21156 T21154 arg1Of Schuell,Schleicher
R16608 T21156 T21155 arg1Of Schuell,&
R16609 T21157 T21153 arg3Of ),(
R16610 T21162 T21158 arg2Of unit,in
R16611 T21162 T21159 arg1Of unit,a
R16612 T21162 T21160 arg1Of unit,Bio-Rad
R16613 T21162 T21161 arg1Of unit,transfer
R16614 T21163 T21164 arg1Of Membranes,were
R16615 T21163 T21165 arg2Of Membranes,immunoblotted
R16616 T21165 T21164 arg2Of immunoblotted,were
R16617 T21165 T21166 arg1Of immunoblotted,with
R16618 T21170 T21166 arg2Of antibody,with
R16619 T21170 T21167 arg1Of antibody,the
R16620 T21170 T21168 arg1Of antibody,appropriate
R16621 T21170 T21169 arg1Of antibody,primary
R16622 T21170 T21171 arg2Of antibody,followed
R16623 T21173 T21171 arg1Of horseradish,followed
R16624 T21173 T21172 arg2Of horseradish,by
R16625 T21173 T21174 arg2Of horseradish,peroxidase–tagged
R16626 T21173 T21184 arg2Of horseradish,detected
R16627 T21174 T21183 arg1Of peroxidase–tagged,and
R16628 T21176 T21174 arg3Of antibodies,peroxidase–tagged
R16629 T21176 T21175 arg1Of antibodies,secondary
R16630 T21176 T21177 arg1Of antibodies,(
R16631 T21179 T21178 arg1Of Biosciences,Amersham
R16632 T21179 T21180 arg1Of Biosciences,and
R16633 T21180 T21177 arg2Of and,(
R16634 T21181 T21180 arg2Of Dako,and
R16635 T21182 T21177 arg3Of ),(
R16636 T21184 T21183 arg2Of detected,and
R16637 T21184 T21185 arg1Of detected,with
R16638 T21190 T21185 arg2Of System,with
R16639 T21190 T21186 arg1Of System,the
R16640 T21190 T21187 arg1Of System,SuperSignal
R16641 T21190 T21188 arg1Of System,West
R16642 T21190 T21189 arg1Of System,Pico
R16643 T21190 T21191 arg1Of System,(
R16644 T21192 T21191 arg2Of Pierce,(
R16645 T21193 T21191 arg3Of ),(
R17146 T21926 T21924 arg1Of Expression,High
R17147 T21926 T21925 arg1Of Expression,LMP1
R17148 T21926 T21927 arg1Of Expression,Correlates
R17149 T21927 T21928 arg1Of Correlates,with
R17150 T21930 T21928 arg2Of Development,with
R17151 T21930 T21929 arg1Of Development,the
R17152 T21930 T21931 arg1Of Development,of
R17153 T21932 T21931 arg2Of Lymphoma,of
R17154 T21934 T21933 arg1Of expression,LMP1
R17155 T21934 T21935 arg1Of expression,is
R17156 T21934 T21936 arg2Of expression,shown
R17157 T21936 T21935 arg2Of shown,is
R17158 T21939 T21938 arg2Of A,(
R17159 T21940 T21938 arg3Of ),(
R17160 T21941 T21938 arg1Of immunoblotting,(
R17161 T21941 T21942 arg1Of immunoblotting,of
R17162 T21941 T21949 arg1Of immunoblotting,and
R17163 T21945 T21942 arg2Of cells,of
R17164 T21945 T21943 arg2Of cells,purified
R17165 T21945 T21944 arg1Of cells,B
R17166 T21945 T21946 arg1Of cells,(
R17167 T21947 T21946 arg2Of CD19+,(
R17168 T21948 T21946 arg3Of ),(
R17169 T21949 T21936 arg1Of and,shown
R17170 T21949 T21937 arg2Of and,by
R17171 T21951 T21950 arg2Of B,(
R17172 T21952 T21950 arg3Of ),(
R17173 T21954 T21949 arg2Of staining,and
R17174 T21954 T21950 arg1Of staining,(
R17175 T21954 T21953 arg1Of staining,immunohistochemistry
R17176 T21954 T21955 arg1Of staining,of
R17177 T21957 T21955 arg2Of tissue,of
R17178 T21957 T21956 arg1Of tissue,spleen
R17179 T21957 T21958 arg1Of tissue,from
R17180 T21959 T21960 arg1Of wild-type,(
R17181 T21959 T21963 arg1Of wild-type,and
R17182 T21961 T21960 arg2Of WT,(
R17183 T21962 T21960 arg3Of ),(
R17184 T21963 T21958 arg2Of and,from
R17185 T21966 T21963 arg2Of mice,and
R17186 T21966 T21964 arg1Of mice,LMP1
R17187 T21966 T21965 arg1Of mice,transgenic
R17188 T21968 T21967 arg2Of A,(
R17189 T21969 T21967 arg3Of ),(
R17190 T21970 T21967 arg1Of Lymphomas,(
R17191 T21970 T21971 arg1Of Lymphomas,are
R17192 T21970 T21972 arg2Of Lymphomas,identified
R17193 T21972 T21971 arg2Of identified,are
R17194 T21972 T21973 arg1Of identified,with
R17195 T21975 T21973 arg2Of number,with
R17196 T21975 T21974 arg1Of number,a
R17197 T21975 T21976 arg1Of number,(
R17198 T21977 T21976 arg2Of 1–7,(
R17199 T21978 T21976 arg3Of ),(
R17200 T21979 T21980 arg1Of Arrows,indicate
R17201 T21983 T21981 arg1Of band,the
R17202 T21983 T21982 arg1Of band,LMP1-specific
R17203 T21983 T21984 arg1Of band,and
R17204 T21984 T21990 arg1Of and,as
R17205 T21987 T21984 arg2Of products,and
R17206 T21987 T21985 arg1Of products,its
R17207 T21987 T21986 arg1Of products,degradation
R17208 T21990 T21980 arg2Of as,indicate
R17209 T21990 T21988 arg1Of as,as
R17210 T21990 T21989 arg1Of as,well
R17211 T21993 T21990 arg2Of band,as
R17212 T21993 T21991 arg1Of band,a
R17213 T21993 T21992 arg1Of band,non-specific
R17214 T21994 T21995 arg1Of Actin,was
R17215 T21994 T21996 arg2Of Actin,used
R17216 T21996 T21995 arg2Of used,was
R17217 T21996 T21997 arg1Of used,as
R17218 T22000 T21997 arg2Of control,as
R17219 T22000 T21998 arg1Of control,a
R17220 T22000 T21999 arg1Of control,loading
R17221 T22002 T22001 arg2Of B,(
R17222 T22003 T22001 arg3Of ),(
R17223 T22004 T22005 arg1Of White,and
R17224 T22006 T22005 arg2Of red,and
R17225 T22007 T22001 arg1Of pulps,(
R17226 T22007 T22004 arg1Of pulps,White
R17227 T22007 T22006 arg1Of pulps,red
R17228 T22007 T22008 arg1Of pulps,are
R17229 T22007 T22009 arg2Of pulps,shown
R17230 T22009 T22008 arg2Of shown,are
R17231 T22009 T22011 arg1Of shown,but
R17232 T22011 T22010 arg1Of but,","
R17233 T22013 T22012 arg1Of architecture,this
R17234 T22013 T22014 arg1Of architecture,is
R17235 T22013 T22015 arg2Of architecture,lost
R17236 T22015 T22011 arg2Of lost,but
R17237 T22015 T22014 arg2Of lost,is
R17238 T22015 T22016 arg1Of lost,upon
R17239 T22017 T22016 arg2Of development,upon
R17240 T22017 T22018 arg1Of development,of
R17241 T22019 T22018 arg2Of lymphoma,of
R17242 T22021 T22020 arg1Of bar,Scale
R17243 T22021 T22022 arg1Of bar,","
R17244 T22024 T22022 arg2Of μm,","
R17245 T22024 T22023 arg1Of μm,20
R17258 T22122 T22123 arg1Of LMP1,Promotes
R17259 T22125 T22123 arg2Of Lymphomas,Promotes
R17260 T22125 T22124 arg1Of Lymphomas,B-1a
R17261 T22125 T22126 arg1Of Lymphomas,That
R17262 T22125 T22127 arg1Of Lymphomas,Can
R17263 T22125 T22130 arg1Of Lymphomas,Exclusion
R17264 T22130 T22128 arg1Of Exclusion,Escape
R17265 T22130 T22129 arg1Of Exclusion,Allelic
R17266 T22132 T22131 arg2Of A,(
R17267 T22133 T22131 arg3Of ),(
R17268 T22136 T22131 arg1Of analysis,(
R17269 T22136 T22134 arg1Of analysis,Flow
R17270 T22136 T22135 arg1Of analysis,cytometry
R17271 T22136 T22137 arg1Of analysis,of
R17272 T22136 T22146 arg1Of analysis,for
R17273 T22138 T22137 arg2Of splenocytes,of
R17274 T22138 T22139 arg1Of splenocytes,from
R17275 T22141 T22142 arg1Of WT,or
R17276 T22143 T22142 arg2Of LMP1,or
R17277 T22145 T22139 arg2Of lymphoma,from
R17278 T22145 T22140 arg1Of lymphoma,a
R17279 T22145 T22141 arg1Of lymphoma,WT
R17280 T22145 T22143 arg1Of lymphoma,LMP1
R17281 T22145 T22144 arg1Of lymphoma,transgenic
R17282 T22149 T22148 arg1Of cell,pan–B
R17283 T22149 T22150 arg1Of cell,(
R17284 T22149 T22153 arg1Of cell,","
R17285 T22151 T22150 arg2Of CD19,(
R17286 T22152 T22150 arg3Of ),(
R17287 T22154 T22153 arg2Of B-1a,","
R17288 T22155 T22149 arg1Of cell,cell
R17289 T22155 T22154 arg1Of cell,B-1a
R17290 T22155 T22156 arg1Of cell,(
R17291 T22155 T22160 arg1Of cell,and
R17292 T22157 T22156 arg2Of CD5,(
R17293 T22158 T22156 arg3Of ),(
R17294 T22160 T22159 arg1Of and,","
R17295 T22160 T22169 arg1Of and,and
R17296 T22163 T22160 arg2Of chain,and
R17297 T22163 T22161 arg1Of chain,Ig
R17298 T22163 T22162 arg1Of chain,heavy
R17299 T22163 T22164 arg1Of chain,(
R17300 T22165 T22166 arg1Of IgM,and
R17301 T22166 T22164 arg2Of and,(
R17302 T22167 T22166 arg2Of IgD,and
R17303 T22168 T22164 arg3Of ),(
R17304 T22169 T22146 arg2Of and,for
R17305 T22169 T22147 arg1Of and,the
R17306 T22171 T22169 arg2Of chain,and
R17307 T22171 T22170 arg1Of chain,light
R17308 T22173 T22174 arg1Of κ,and
R17309 T22174 T22146 arg3Of and,for
R17310 T22174 T22172 arg1Of and,(
R17311 T22175 T22176 arg1Of λ,)
R17312 T22177 T22174 arg2Of markers,and
R17313 T22177 T22175 arg1Of markers,λ
R17314 T22179 T22178 modOf are,Shown
R17315 T22181 T22178 arg2Of results,Shown
R17316 T22181 T22179 arg1Of results,are
R17317 T22181 T22180 arg1Of results,the
R17318 T22181 T22182 arg1Of results,from
R17319 T22184 T22183 arg1Of lymphoma,WT
R17320 T22184 T22185 arg1Of lymphoma,1
R17321 T22184 T22186 arg1Of lymphoma,and
R17322 T22186 T22182 arg2Of and,from
R17323 T22189 T22186 arg2Of lymphoma,and
R17324 T22189 T22187 arg1Of lymphoma,LMP1
R17325 T22189 T22188 arg1Of lymphoma,transgenic
R17326 T22189 T22190 arg1Of lymphoma,4
R17327 T22192 T22191 arg1Of analysis,This
R17328 T22192 T22193 arg1Of analysis,was
R17329 T22192 T22194 arg2Of analysis,repeated
R17330 T22194 T22193 arg2Of repeated,was
R17331 T22194 T22195 arg1Of repeated,on
R17332 T22200 T22195 arg2Of lymphomas,on
R17333 T22200 T22196 arg1Of lymphomas,four
R17334 T22200 T22197 arg1Of lymphomas,other
R17335 T22200 T22198 arg1Of lymphomas,LMP1
R17336 T22200 T22199 arg1Of lymphomas,transgenic
R17337 T22200 T22201 arg1Of lymphomas,(
R17338 T22200 T22211 arg1Of lymphomas,showing
R17339 T22200 T22216 arg1Of lymphomas,","
R17340 T22200 T22217 arg2Of lymphomas,of
R17341 T22200 T22218 arg1Of lymphomas,which
R17342 T22202 T22203 arg1Of 1,","
R17343 T22203 T22205 arg1Of ",",","
R17344 T22204 T22203 arg2Of 2,","
R17345 T22205 T22208 arg1Of ",",and
R17346 T22206 T22205 arg2Of 3,","
R17347 T22208 T22201 arg2Of and,(
R17348 T22208 T22207 arg1Of and,","
R17349 T22209 T22208 arg2Of 6,and
R17350 T22210 T22201 arg3Of ),(
R17351 T22215 T22211 arg2Of phenotype,showing
R17352 T22215 T22212 arg1Of phenotype,a
R17353 T22215 T22213 arg1Of phenotype,similar
R17354 T22215 T22214 arg1Of phenotype,B-1a
R17355 T22220 T22221 arg1Of 2,and
R17356 T22221 T22219 arg1Of and,lymphomas
R17357 T22221 T22223 arg1Of and,were
R17358 T22221 T22226 arg1Of and,positive
R17359 T22221 T22230 arg1Of and,λ
R17360 T22222 T22221 arg2Of 4,and
R17361 T22223 T22224 arg1Of were,also
R17362 T22223 T22229 arg1Of were,and
R17363 T22226 T22223 arg2Of positive,were
R17364 T22226 T22225 arg1Of positive,doubly
R17365 T22226 T22227 arg1Of positive,for
R17366 T22228 T22227 arg2Of κ,for
R17367 T22229 T22217 arg1Of and,of
R17368 T22230 T22229 arg2Of λ,and
R17369 T22232 T22230 arg2Of chains,λ
R17370 T22232 T22231 arg1Of chains,light
R17371 T22234 T22233 arg2Of B,(
R17372 T22235 T22233 arg3Of ),(
R17373 T22238 T22233 arg1Of analysis,(
R17374 T22238 T22236 arg1Of analysis,Flow
R17375 T22238 T22237 arg1Of analysis,cytometry
R17376 T22238 T22239 arg1Of analysis,of
R17377 T22238 T22245 arg1Of analysis,for
R17378 T22238 T22255 arg1Of analysis,(
R17379 T22240 T22241 arg1Of WT,or
R17380 T22242 T22241 arg2Of LMP1,or
R17381 T22244 T22239 arg2Of splenocytes,of
R17382 T22244 T22240 arg1Of splenocytes,WT
R17383 T22244 T22242 arg1Of splenocytes,LMP1
R17384 T22244 T22243 arg1Of splenocytes,transgenic
R17385 T22246 T22247 arg1Of B-1a,(
R17386 T22246 T22250 arg1Of B-1a,and
R17387 T22248 T22247 arg2Of CD19+CD5+,(
R17388 T22249 T22247 arg3Of ),(
R17389 T22251 T22252 arg1Of B-1b,or
R17390 T22252 T22250 arg2Of or,and
R17391 T22253 T22252 arg2Of B2,or
R17392 T22254 T22245 arg2Of subsets,for
R17393 T22254 T22246 arg1Of subsets,B-1a
R17394 T22254 T22251 arg1Of subsets,B-1b
R17395 T22254 T22253 arg1Of subsets,B2
R17396 T22256 T22255 arg2Of CD19+CD5−,(
R17397 T22257 T22255 arg3Of ),(
R17398 T22258 T22259 arg1Of Percentages,of
R17399 T22258 T22266 arg1Of Percentages,are
R17400 T22258 T22267 arg2Of Percentages,shown
R17401 T22260 T22261 arg1Of B-1a,and
R17402 T22261 T22263 arg1Of and,or
R17403 T22262 T22261 arg2Of B-1b,and
R17404 T22264 T22263 arg2Of B2,or
R17405 T22265 T22259 arg2Of subsets,of
R17406 T22265 T22260 arg1Of subsets,B-1a
R17407 T22265 T22262 arg1Of subsets,B-1b
R17408 T22265 T22264 arg1Of subsets,B2
R17409 T22267 T22266 arg2Of shown,are
R17410 T22267 T22268 arg1Of shown,in
R17411 T22270 T22268 arg2Of quadrant,in
R17412 T22270 T22269 arg1Of quadrant,each
R17413 T22272 T22271 arg1Of analysis,This
R17414 T22272 T22273 arg1Of analysis,was
R17415 T22272 T22274 arg2Of analysis,repeated
R17416 T22274 T22273 arg2Of repeated,was
R17417 T22274 T22275 arg1Of repeated,on
R17418 T22278 T22276 arg1Of WT,three
R17419 T22278 T22277 arg1Of WT,other
R17420 T22278 T22279 arg1Of WT,and
R17421 T22279 T22275 arg2Of and,on
R17422 T22284 T22279 arg2Of mice,and
R17423 T22284 T22280 arg1Of mice,two
R17424 T22284 T22281 arg1Of mice,other
R17425 T22284 T22282 arg1Of mice,LMP1
R17426 T22284 T22283 arg1Of mice,transgenic
R17427 T22284 T22285 arg1Of mice,with
R17428 T22287 T22285 arg2Of results,with
R17429 T22287 T22286 arg1Of results,similar
R17430 T22289 T22288 arg2Of C,(
R17431 T22290 T22288 arg3Of ),(
R17432 T22292 T22288 arg1Of analysis,(
R17433 T22292 T22291 arg1Of analysis,Immunoblot
R17434 T22292 T22293 arg1Of analysis,for
R17435 T22292 T22305 arg2Of analysis,purified
R17436 T22294 T22295 arg1Of κ,and
R17437 T22295 T22293 arg2Of and,for
R17438 T22298 T22295 arg2Of chains,and
R17439 T22298 T22296 arg1Of chains,λ
R17440 T22298 T22297 arg1Of chains,light
R17441 T22298 T22299 arg1Of chains,of
R17442 T22301 T22299 arg2Of cells,of
R17443 T22301 T22300 arg1Of cells,B
R17444 T22301 T22302 arg1Of cells,(
R17445 T22303 T22302 arg2Of CD19+,(
R17446 T22304 T22302 arg3Of ),(
R17447 T22305 T22306 arg1Of purified,from
R17448 T22307 T22308 arg1Of WT,and
R17449 T22309 T22308 arg2Of LMP1,and
R17450 T22311 T22306 arg2Of mice,from
R17451 T22311 T22307 arg1Of mice,WT
R17452 T22311 T22309 arg1Of mice,LMP1
R17453 T22311 T22310 arg1Of mice,transgenic
R17454 T22312 T22313 arg1Of Actin,was
R17455 T22312 T22314 arg2Of Actin,used
R17456 T22314 T22313 arg2Of used,was
R17457 T22314 T22315 arg1Of used,as
R17458 T22318 T22315 arg2Of control,as
R17459 T22318 T22316 arg1Of control,a
R17460 T22318 T22317 arg1Of control,loading
R17674 T22664 T22665 arg1Of LMP1,Promotes
R17675 T22668 T22669 arg1Of Survival,and
R17676 T22669 T22665 arg2Of and,Promotes
R17677 T22669 T22666 arg1Of and,B
R17678 T22669 T22667 arg1Of and,Cell
R17679 T22669 T22671 arg1Of and,In
R17680 T22670 T22669 arg2Of Proliferation,and
R17681 T22672 T22671 arg2Of Vitro,In
R17682 T22674 T22673 arg2Of A,(
R17683 T22675 T22673 arg3Of ),(
R17684 T22677 T22673 arg1Of assay,(
R17685 T22677 T22676 arg1Of assay,MTS
R17686 T22677 T22678 arg1Of assay,of
R17687 T22679 T22678 arg2Of splenocytes,of
R17688 T22679 T22680 arg1Of splenocytes,from
R17689 T22681 T22682 arg1Of WT,and
R17690 T22683 T22682 arg2Of LMP1,and
R17691 T22685 T22680 arg2Of mice,from
R17692 T22685 T22681 arg1Of mice,WT
R17693 T22685 T22683 arg1Of mice,LMP1
R17694 T22685 T22684 arg1Of mice,transgenic
R17695 T22686 T22687 arg1Of Splenocytes,were
R17696 T22686 T22688 arg2Of Splenocytes,cultured
R17697 T22688 T22687 arg2Of cultured,were
R17698 T22688 T22689 arg1Of cultured,in
R17699 T22688 T22704 arg1Of cultured,for
R17700 T22691 T22690 arg1Of presence,the
R17701 T22691 T22692 arg1Of presence,(
R17702 T22691 T22696 arg1Of presence,or
R17703 T22694 T22692 arg2Of bars,(
R17704 T22694 T22693 arg1Of bars,grey
R17705 T22695 T22692 arg3Of ),(
R17706 T22696 T22689 arg2Of or,in
R17707 T22697 T22696 arg2Of absence,or
R17708 T22697 T22698 arg1Of absence,(
R17709 T22697 T22702 arg1Of absence,of
R17710 T22700 T22698 arg2Of bars,(
R17711 T22700 T22699 arg1Of bars,black
R17712 T22701 T22698 arg3Of ),(
R17713 T22703 T22702 arg2Of IL4,of
R17714 T22706 T22704 arg2Of d,for
R17715 T22706 T22705 arg1Of d,3
R17716 T22708 T22707 arg1Of results,The
R17717 T22708 T22709 arg1Of results,are
R17718 T22713 T22710 arg1Of SEM,the
R17719 T22713 T22711 arg1Of SEM,mean
R17720 T22713 T22712 arg1Of SEM,±
R17721 T22713 T22714 arg1Of SEM,of
R17722 T22713 T22717 arg1Of SEM,averaged
R17723 T22716 T22714 arg2Of samples,of
R17724 T22716 T22715 arg1Of samples,triplicate
R17725 T22717 T22709 arg2Of averaged,are
R17726 T22717 T22718 arg1Of averaged,from
R17727 T22720 T22718 arg2Of mice,from
R17728 T22720 T22719 arg1Of mice,multiple
R17729 T22720 T22721 arg1Of mice,where
R17730 T22724 T22722 arg1Of number,“n”
R17731 T22724 T22723 arg1Of number,the
R17732 T22724 T22725 arg1Of number,of
R17733 T22724 T22728 arg1Of number,is
R17734 T22724 T22730 arg1Of number,follows
R17735 T22726 T22725 arg2Of mice,of
R17736 T22726 T22727 arg2Of mice,analyzed
R17737 T22730 T22721 arg2Of follows,where
R17738 T22730 T22728 arg2Of follows,is
R17739 T22730 T22729 arg1Of follows,as
R17740 T22730 T22731 arg1Of follows,:
R17741 T22732 T22733 arg1Of n,=
R17742 T22732 T22750 arg1Of n,and
R17743 T22733 T22734 arg1Of =,2
R17744 T22733 T22735 arg1Of =,for
R17745 T22737 T22736 arg1Of lymphocytes,WT
R17746 T22737 T22738 arg1Of lymphocytes,and
R17747 T22738 T22735 arg2Of and,for
R17748 T22738 T22741 arg1Of and,","
R17749 T22740 T22738 arg2Of lymphomas,and
R17750 T22740 T22739 arg1Of lymphomas,WT
R17751 T22742 T22741 arg2Of n,","
R17752 T22742 T22745 arg1Of n,for
R17753 T22743 T22744 arg1Of =,11
R17754 T22745 T22743 arg1Of for,=
R17755 T22748 T22745 arg2Of lymphocytes,for
R17756 T22748 T22746 arg1Of lymphocytes,LMP1
R17757 T22748 T22747 arg1Of lymphocytes,transgenic
R17758 T22750 T22730 arg2Of and,follows
R17759 T22750 T22749 arg1Of and,","
R17760 T22751 T22750 arg2Of n,and
R17761 T22751 T22752 arg1Of n,=
R17762 T22752 T22753 arg1Of =,13
R17763 T22752 T22754 arg1Of =,for
R17764 T22757 T22754 arg2Of lymphomas,for
R17765 T22757 T22755 arg1Of lymphomas,LMP1
R17766 T22757 T22756 arg1Of lymphomas,transgenic
R17767 T22759 T22758 arg2Of B,(
R17768 T22760 T22758 arg3Of ),(
R17769 T22762 T22758 arg1Of exclusion,(
R17770 T22762 T22761 arg1Of exclusion,EMA
R17771 T22762 T22763 arg1Of exclusion,of
R17772 T22762 T22767 arg1Of exclusion,from
R17773 T22766 T22763 arg2Of splenocytes,of
R17774 T22766 T22764 arg1Of splenocytes,CD19+
R17775 T22766 T22765 arg1Of splenocytes,gated
R17776 T22768 T22769 arg1Of WT,and
R17777 T22770 T22769 arg2Of LMP1,and
R17778 T22772 T22767 arg2Of mice,from
R17779 T22772 T22768 arg1Of mice,WT
R17780 T22772 T22770 arg1Of mice,LMP1
R17781 T22772 T22771 arg1Of mice,transgenic
R17782 T22772 T22773 arg1Of mice,showing
R17783 T22774 T22773 arg2Of percentage,showing
R17784 T22774 T22775 arg1Of percentage,of
R17785 T22778 T22775 arg2Of cells,of
R17786 T22778 T22776 arg1Of cells,viable
R17787 T22778 T22777 arg1Of cells,B
R17788 T22778 T22779 arg2Of cells,cultured
R17789 T22779 T22780 arg1Of cultured,with
R17790 T22779 T22786 arg1Of cultured,without
R17791 T22780 T22785 arg1Of with,or
R17792 T22783 T22780 arg2Of bars,with
R17793 T22783 T22781 arg2Of bars,(
R17794 T22783 T22782 arg1Of bars,white
R17795 T22784 T22781 arg3Of ),(
R17796 T22786 T22785 arg2Of without,or
R17797 T22789 T22787 arg2Of bars,(
R17798 T22789 T22788 arg1Of bars,black
R17799 T22790 T22787 arg3Of ),(
R17800 T22791 T22786 arg2Of IL4,without
R17801 T22791 T22787 arg1Of IL4,(
R17802 T22791 T22792 arg1Of IL4,for
R17803 T22794 T22792 arg2Of d,for
R17804 T22794 T22793 arg1Of d,2
R17805 T22796 T22795 arg2Of C,(
R17806 T22797 T22795 arg3Of ),(
R17807 T22800 T22795 arg1Of analysis,(
R17808 T22800 T22798 arg1Of analysis,Flow
R17809 T22800 T22799 arg1Of analysis,cytometry
R17810 T22800 T22801 arg1Of analysis,for
R17811 T22800 T22804 arg1Of analysis,in
R17812 T22803 T22801 arg2Of BrdU,for
R17813 T22803 T22802 arg1Of BrdU,incorporated
R17814 T22805 T22806 arg1Of WT,and
R17815 T22807 T22806 arg2Of LMP1,and
R17816 T22810 T22804 arg2Of cells,in
R17817 T22810 T22805 arg1Of cells,WT
R17818 T22810 T22807 arg1Of cells,LMP1
R17819 T22810 T22808 arg1Of cells,transgenic
R17820 T22810 T22809 arg1Of cells,lymphoma
R17821 T22810 T22811 arg2Of cells,cultured
R17822 T22811 T22812 arg1Of cultured,with
R17823 T22811 T22814 arg1Of cultured,without
R17824 T22811 T22816 arg1Of cultured,for
R17825 T22812 T22813 arg1Of with,or
R17826 T22814 T22813 arg2Of without,or
R17827 T22815 T22812 arg2Of IL4,with
R17828 T22815 T22814 arg2Of IL4,without
R17829 T22818 T22816 arg2Of d,for
R17830 T22818 T22817 arg1Of d,2
R17831 T22820 T22819 modOf are,Shown
R17832 T22822 T22819 arg2Of results,Shown
R17833 T22822 T22820 arg1Of results,are
R17834 T22822 T22821 arg1Of results,the
R17835 T22822 T22823 arg1Of results,from
R17836 T22825 T22824 arg1Of lymphoma,WT
R17837 T22825 T22826 arg1Of lymphoma,1
R17838 T22825 T22827 arg1Of lymphoma,and
R17839 T22827 T22823 arg2Of and,from
R17840 T22830 T22827 arg2Of lymphoma,and
R17841 T22830 T22828 arg1Of lymphoma,LMP1
R17842 T22830 T22829 arg1Of lymphoma,transgenic
R17843 T22830 T22831 arg1Of lymphoma,2
R17844 T22832 T22833 arg1Of Percentages,of
R17845 T22832 T22838 arg1Of Percentages,are
R17846 T22832 T22839 arg2Of Percentages,shown
R17847 T22834 T22833 arg2Of cells,of
R17848 T22834 T22835 arg1Of cells,in
R17849 T22837 T22835 arg2Of quadrant,in
R17850 T22837 T22836 arg1Of quadrant,each
R17851 T22839 T22838 arg2Of shown,are
R18037 T23152 T23153 arg1Of Wild-Type,and
R18038 T23159 T23153 arg2Of Independently,and
R18039 T23159 T23154 arg1Of Independently,LMP1
R18040 T23159 T23155 arg1Of Independently,Transgenic
R18041 T23159 T23156 arg1Of Independently,Lymphoma
R18042 T23159 T23157 arg1Of Independently,Cells
R18043 T23159 T23158 arg1Of Independently,Survive
R18044 T23159 T23160 arg1Of Independently,of
R18045 T23162 T23160 arg2Of Signaling,of
R18046 T23162 T23161 arg1Of Signaling,IL4/Stat6
R18047 T23162 T23163 arg1Of Signaling,in
R18048 T23164 T23163 arg2Of Culture,in
R18049 T23166 T23165 arg2Of A,(
R18050 T23167 T23165 arg3Of ),(
R18051 T23170 T23165 arg1Of assay,(
R18052 T23170 T23168 arg1Of assay,Rnase
R18053 T23170 T23169 arg1Of assay,protection
R18054 T23170 T23171 arg1Of assay,for
R18055 T23170 T23181 arg1Of assay,from
R18056 T23173 T23171 arg2Of mRNA,for
R18057 T23173 T23172 arg1Of mRNA,IL4
R18058 T23173 T23174 arg1Of mRNA,from
R18059 T23177 T23174 arg2Of cells,from
R18060 T23177 T23175 arg2Of cells,purified
R18061 T23177 T23176 arg1Of cells,B
R18062 T23177 T23178 arg1Of cells,(
R18063 T23179 T23178 arg2Of CD19+,(
R18064 T23180 T23178 arg3Of ),(
R18065 T23182 T23183 arg1Of WT,and
R18066 T23184 T23183 arg2Of LMP1,and
R18067 T23186 T23181 arg2Of splenocytes,from
R18068 T23186 T23182 arg1Of splenocytes,WT
R18069 T23186 T23184 arg1Of splenocytes,LMP1
R18070 T23186 T23185 arg1Of splenocytes,transgenic
R18071 T23188 T23189 arg1Of L32,and
R18072 T23190 T23189 arg2Of GAPDH,and
R18073 T23192 T23187 arg1Of genes,The
R18074 T23192 T23188 arg1Of genes,L32
R18075 T23192 T23190 arg1Of genes,GAPDH
R18076 T23192 T23191 arg1Of genes,housekeeping
R18077 T23192 T23193 arg1Of genes,were
R18078 T23192 T23194 arg2Of genes,used
R18079 T23194 T23193 arg2Of used,were
R18080 T23194 T23195 arg1Of used,as
R18081 T23198 T23195 arg2Of control,as
R18082 T23198 T23196 arg1Of control,a
R18083 T23198 T23197 arg1Of control,loading
R18084 T23199 T23200 arg1Of Arrow,indicates
R18085 T23202 T23200 arg2Of position,indicates
R18086 T23202 T23201 arg1Of position,the
R18087 T23202 T23203 arg1Of position,of
R18088 T23206 T23203 arg2Of probe,of
R18089 T23206 T23204 arg1Of probe,the
R18090 T23206 T23205 arg1Of probe,protected
R18091 T23208 T23209 arg1Of B,and
R18092 T23209 T23254 arg1Of and,was
R18093 T23209 T23255 arg2Of and,used
R18094 T23213 T23209 arg2Of analysis,and
R18095 T23213 T23210 arg1Of analysis,C
R18096 T23213 T23211 arg1Of analysis,)
R18097 T23213 T23212 arg1Of analysis,Immunoblot
R18098 T23213 T23214 arg1Of analysis,of
R18099 T23215 T23216 arg1Of WT,and
R18100 T23217 T23216 arg2Of LMP1,and
R18101 T23219 T23214 arg2Of mice,of
R18102 T23219 T23215 arg1Of mice,WT
R18103 T23219 T23217 arg1Of mice,LMP1
R18104 T23219 T23218 arg1Of mice,transgenic
R18105 T23219 T23220 arg1Of mice,for
R18106 T23222 T23220 arg2Of pStat6,for
R18107 T23222 T23221 arg2Of pStat6,activated
R18108 T23223 T23233 arg1Of in,at
R18109 T23223 T23238 arg1Of in,or
R18110 T23225 T23224 arg2Of B,(
R18111 T23226 T23224 arg3Of ),(
R18112 T23229 T23223 arg2Of cells,in
R18113 T23229 T23224 arg1Of cells,(
R18114 T23229 T23227 arg2Of cells,purified
R18115 T23229 T23228 arg1Of cells,B
R18116 T23229 T23230 arg1Of cells,(
R18117 T23231 T23230 arg2Of CD19+,(
R18118 T23232 T23230 arg3Of ),(
R18119 T23235 T23233 arg2Of time,at
R18120 T23235 T23234 arg1Of time,the
R18121 T23235 T23236 arg1Of time,of
R18122 T23237 T23236 arg2Of harvest,of
R18123 T23238 T23220 arg3Of or,for
R18124 T23239 T23238 arg2Of in,or
R18125 T23241 T23240 arg2Of C,(
R18126 T23242 T23240 arg3Of ),(
R18127 T23244 T23239 arg2Of splenocytes,in
R18128 T23244 T23240 arg1Of splenocytes,(
R18129 T23244 T23243 arg1Of splenocytes,whole
R18130 T23244 T23245 arg2Of splenocytes,cultured
R18131 T23245 T23246 arg1Of cultured,with
R18132 T23245 T23248 arg1Of cultured,without
R18133 T23246 T23247 arg1Of with,or
R18134 T23248 T23247 arg2Of without,or
R18135 T23251 T23250 arg2Of B,(
R18136 T23252 T23250 arg3Of ),(
R18137 T23253 T23246 arg2Of Actin,with
R18138 T23253 T23248 arg2Of Actin,without
R18139 T23253 T23249 arg1Of Actin,IL4.
R18140 T23253 T23250 arg1Of Actin,(
R18141 T23255 T23254 arg2Of used,was
R18142 T23255 T23256 arg1Of used,as
R18143 T23255 T23261 arg1Of used,and
R18144 T23259 T23256 arg2Of control,as
R18145 T23259 T23257 arg1Of control,a
R18146 T23259 T23258 arg1Of control,loading
R18147 T23261 T23207 arg1Of and,(
R18148 T23261 T23260 arg1Of and,","
R18149 T23264 T23262 arg1Of line,the
R18150 T23264 T23263 arg1Of line,white
R18151 T23264 T23265 arg1Of line,indicates
R18152 T23265 T23261 arg2Of indicates,and
R18153 T23268 T23267 arg1Of lanes,intervening
R18154 T23268 T23269 arg1Of lanes,have
R18155 T23268 T23270 arg1Of lanes,been
R18156 T23268 T23271 arg2Of lanes,spliced
R18157 T23271 T23265 arg2Of spliced,indicates
R18158 T23271 T23266 arg1Of spliced,that
R18159 T23271 T23269 arg2Of spliced,have
R18160 T23271 T23270 arg2Of spliced,been
R18161 T23271 T23272 arg1Of spliced,out
R18162 T23274 T23275 arg1Of D,and
R18163 T23275 T23273 arg1Of and,(
R18164 T23275 T23294 arg2Of and,cultured
R18165 T23279 T23275 arg2Of assay,and
R18166 T23279 T23276 arg1Of assay,E
R18167 T23279 T23277 arg1Of assay,)
R18168 T23279 T23278 arg1Of assay,MTS
R18169 T23279 T23280 arg1Of assay,of
R18170 T23282 T23281 arg2Of D,(
R18171 T23283 T23281 arg3Of ),(
R18172 T23285 T23281 arg1Of lymphocytes,(
R18173 T23285 T23284 arg1Of lymphocytes,WT
R18174 T23285 T23286 arg1Of lymphocytes,and
R18175 T23286 T23280 arg2Of and,of
R18176 T23288 T23287 arg2Of E,(
R18177 T23289 T23287 arg3Of ),(
R18178 T23293 T23286 arg2Of cells,and
R18179 T23293 T23287 arg1Of cells,(
R18180 T23293 T23290 arg1Of cells,LMP1
R18181 T23293 T23291 arg1Of cells,transgenic
R18182 T23293 T23292 arg1Of cells,lymphoma
R18183 T23294 T23295 arg1Of cultured,with
R18184 T23296 T23297 arg1Of IL4,","
R18185 T23296 T23304 arg1Of IL4,or
R18186 T23300 T23297 arg2Of antibody,","
R18187 T23300 T23298 arg1Of antibody,a
R18188 T23300 T23299 arg1Of antibody,neutralizing
R18189 T23300 T23301 arg1Of antibody,to
R18190 T23302 T23301 arg2Of IL4,to
R18191 T23304 T23295 arg2Of or,with
R18192 T23304 T23303 arg1Of or,","
R18193 T23309 T23304 arg2Of control,or
R18194 T23309 T23305 arg1Of control,a
R18195 T23309 T23306 arg1Of control,rat
R18196 T23309 T23307 arg1Of control,IgG
R18197 T23309 T23308 arg1Of control,isotype
R18198 T23309 T23310 arg1Of control,at
R18199 T23313 T23310 arg2Of concentrations,at
R18200 T23313 T23311 arg1Of concentrations,the
R18201 T23313 T23312 arg2Of concentrations,indicated
R18202 T23315 T23314 modOf are,Shown
R18203 T23317 T23314 arg2Of results,Shown
R18204 T23317 T23315 arg1Of results,are
R18205 T23317 T23316 arg1Of results,the
R18206 T23317 T23318 arg1Of results,from
R18207 T23321 T23318 arg2Of lymphoma,from
R18208 T23321 T23319 arg1Of lymphoma,LMP1
R18209 T23321 T23320 arg1Of lymphoma,transgenic
R18210 T23321 T23322 arg1Of lymphoma,3
R18211 T23324 T23323 arg1Of results,The
R18212 T23324 T23325 arg1Of results,are
R18213 T23329 T23325 arg2Of SEM,are
R18214 T23329 T23326 arg1Of SEM,the
R18215 T23329 T23327 arg1Of SEM,mean
R18216 T23329 T23328 arg1Of SEM,±
R18217 T23329 T23330 arg1Of SEM,of
R18218 T23329 T23338 arg1Of SEM,that
R18219 T23329 T23339 arg1Of SEM,was
R18220 T23329 T23340 arg2Of SEM,repeated
R18221 T23332 T23330 arg2Of samples,of
R18222 T23332 T23331 arg1Of samples,triplicate
R18223 T23332 T23333 arg1Of samples,from
R18224 T23337 T23333 arg2Of experiment,from
R18225 T23337 T23334 arg1Of experiment,a
R18226 T23337 T23335 arg1Of experiment,single
R18227 T23337 T23336 arg1Of experiment,representative
R18228 T23340 T23339 arg2Of repeated,was
R18229 T23340 T23341 arg1Of repeated,twice
R18230 T23340 T23342 arg1Of repeated,with
R18231 T23344 T23342 arg2Of results,with
R18232 T23344 T23343 arg1Of results,similar
R18471 T23741 T23742 arg1Of LMP1,Upregulates
R18474 T23744 T23742 arg2Of Expression,Upregulates
R18476 T23747 T23746 arg1Of Activates,Constitutively
R18477 T23748 T23747 arg2Of Stat3,Activates
R18478 T23750 T23749 arg2Of A,(
R18479 T23751 T23749 arg3Of ),(
R18480 T23753 T23749 arg1Of expression,(
R18481 T23753 T23752 arg1Of expression,Relative
R18482 T23753 T23754 arg1Of expression,of
R18483 T23753 T23762 arg1Of expression,in
R18484 T23753 T23772 arg1Of expression,","
R18485 T23753 T23773 arg1Of expression,as
R18486 T23755 T23756 arg1Of IL10,","
R18487 T23756 T23759 arg1Of ",",and
R18488 T23757 T23756 arg2Of IL15,","
R18489 T23759 T23754 arg2Of and,of
R18490 T23759 T23758 arg1Of and,","
R18491 T23761 T23759 arg2Of mRNA,and
R18492 T23761 T23760 arg1Of mRNA,IFNγ
R18493 T23763 T23764 arg1Of WT,and
R18494 T23765 T23764 arg2Of LMP1,and
R18495 T23768 T23762 arg2Of cells,in
R18496 T23768 T23763 arg1Of cells,WT
R18497 T23768 T23765 arg1Of cells,LMP1
R18498 T23768 T23766 arg1Of cells,transgenic
R18499 T23768 T23767 arg1Of cells,B
R18500 T23768 T23769 arg1Of cells,(
R18501 T23770 T23769 arg2Of CD19+,(
R18502 T23771 T23769 arg3Of ),(
R18503 T23774 T23773 arg2Of detected,as
R18504 T23774 T23775 arg1Of detected,with
R18505 T23779 T23775 arg2Of assay,with
R18506 T23779 T23776 arg1Of assay,an
R18507 T23779 T23777 arg1Of assay,Rnase
R18508 T23779 T23778 arg1Of assay,protection
R18509 T23783 T23780 arg1Of lines,Mouse
R18510 T23783 T23781 arg1Of lines,lymphoma
R18511 T23783 T23782 arg1Of lines,cell
R18512 T23784 T23785 arg1Of 967,and
R18513 T23785 T23783 arg1Of and,lines
R18514 T23785 T23787 arg1Of and,were
R18515 T23785 T23788 arg2Of and,used
R18516 T23786 T23785 arg2Of K46μ,and
R18517 T23788 T23787 arg2Of used,were
R18518 T23788 T23789 arg1Of used,as
R18519 T23790 T23789 arg2Of controls,as
R18520 T23792 T23791 arg1Of levels,Expression
R18521 T23792 T23793 arg1Of levels,were
R18522 T23792 T23794 arg2Of levels,quantified
R18523 T23794 T23793 arg2Of quantified,were
R18524 T23794 T23795 arg1Of quantified,with
R18525 T23794 T23798 arg1Of quantified,and
R18526 T23797 T23795 arg2Of phosphorimager,with
R18527 T23797 T23796 arg1Of phosphorimager,a
R18528 T23799 T23800 arg1Of values,were
R18529 T23799 T23801 arg2Of values,normalized
R18530 T23801 T23798 arg2Of normalized,and
R18531 T23801 T23800 arg2Of normalized,were
R18532 T23801 T23802 arg1Of normalized,to
R18533 T23807 T23802 arg2Of L32,to
R18534 T23807 T23803 arg1Of L32,the
R18535 T23807 T23804 arg1Of L32,ribosomal
R18536 T23807 T23805 arg1Of L32,housekeeping
R18537 T23807 T23806 arg1Of L32,gene
R18538 T23809 T23810 arg1Of cytokine,:
R18539 T23811 T23810 arg2Of L32,:
R18540 T23812 T23808 arg1Of ratio,The
R18541 T23812 T23809 arg1Of ratio,cytokine
R18542 T23812 T23811 arg1Of ratio,L32
R18543 T23812 T23813 arg1Of ratio,was
R18544 T23812 T23814 arg2Of ratio,set
R18545 T23814 T23813 arg2Of set,was
R18546 T23814 T23815 arg1Of set,to
R18547 T23814 T23817 arg1Of set,in
R18548 T23816 T23815 arg2Of 1,to
R18549 T23823 T23817 arg2Of line,in
R18550 T23823 T23818 arg1Of line,the
R18551 T23823 T23819 arg1Of line,mouse
R18552 T23823 T23820 arg1Of line,B
R18553 T23823 T23821 arg1Of line,cell
R18554 T23823 T23822 arg1Of line,lymphoma
R18555 T23823 T23824 arg1Of line,967
R18556 T23826 T23827 arg1Of B,and
R18557 T23827 T23851 arg1Of and,at
R18558 T23827 T23857 arg1Of and,and
R18559 T23831 T23827 arg2Of analysis,and
R18560 T23831 T23828 arg1Of analysis,C
R18561 T23831 T23829 arg1Of analysis,)
R18562 T23831 T23830 arg1Of analysis,Immunoblot
R18563 T23831 T23832 arg1Of analysis,of
R18564 T23831 T23842 arg1Of analysis,from
R18565 T23834 T23832 arg2Of pStat3,of
R18566 T23834 T23833 arg2Of pStat3,activated
R18567 T23834 T23835 arg1Of pStat3,in
R18568 T23838 T23835 arg2Of cells,in
R18569 T23838 T23836 arg2Of cells,purified
R18570 T23838 T23837 arg1Of cells,B
R18571 T23838 T23839 arg1Of cells,(
R18572 T23840 T23839 arg2Of CD19+,(
R18573 T23841 T23839 arg3Of ),(
R18574 T23843 T23844 arg1Of WT,and
R18575 T23845 T23844 arg2Of LMP1,and
R18576 T23847 T23842 arg2Of mice,from
R18577 T23847 T23843 arg1Of mice,WT
R18578 T23847 T23845 arg1Of mice,LMP1
R18579 T23847 T23846 arg1Of mice,transgenic
R18580 T23847 T23848 arg1Of mice,(
R18581 T23849 T23848 arg2Of B,(
R18582 T23850 T23848 arg3Of ),(
R18583 T23853 T23851 arg2Of time,at
R18584 T23853 T23852 arg1Of time,the
R18585 T23853 T23854 arg1Of time,of
R18586 T23855 T23854 arg2Of harvest,of
R18587 T23857 T23856 arg1Of and,","
R18588 T23857 T23886 arg1Of and,are
R18589 T23859 T23858 arg2Of C,(
R18590 T23860 T23858 arg3Of ),(
R18591 T23862 T23858 arg1Of h,(
R18592 T23862 T23861 arg1Of h,4
R18593 T23863 T23862 arg1Of after,h
R18594 T23864 T23863 arg1Of culture,after
R18595 T23864 T23865 arg1Of culture,with
R18596 T23864 T23867 arg1Of culture,without
R18597 T23864 T23876 arg1Of culture,or
R18598 T23865 T23866 arg1Of with,or
R18599 T23867 T23866 arg2Of without,or
R18600 T23868 T23865 arg2Of IL10,with
R18601 T23868 T23867 arg2Of IL10,without
R18602 T23868 T23869 arg1Of IL10,","
R18603 T23872 T23869 arg2Of antibody,","
R18604 T23872 T23870 arg1Of antibody,a
R18605 T23872 T23871 arg1Of antibody,neutralizing
R18606 T23872 T23873 arg1Of antibody,to
R18607 T23874 T23873 arg2Of IL10,to
R18608 T23876 T23857 arg2Of or,and
R18609 T23876 T23875 arg1Of or,","
R18610 T23881 T23879 arg1Of control.,IgG1
R18611 T23881 T23880 arg1Of control.,isotype
R18612 T23881 T23882 arg1Of control.,(
R18613 T23883 T23882 arg2Of C,(
R18614 T23884 T23882 arg3Of ),(
R18615 T23885 T23876 arg2Of Shown,or
R18616 T23885 T23877 arg1Of Shown,a
R18617 T23885 T23878 arg1Of Shown,rat
R18618 T23885 T23881 arg1Of Shown,control.
R18619 T23886 T23825 arg1Of are,(
R18620 T23888 T23886 arg2Of results,are
R18621 T23888 T23887 arg1Of results,the
R18622 T23888 T23889 arg1Of results,for
R18623 T23891 T23890 arg1Of lymphoma,WT
R18624 T23891 T23892 arg1Of lymphoma,1
R18625 T23891 T23893 arg1Of lymphoma,and
R18626 T23893 T23889 arg2Of and,for
R18627 T23896 T23893 arg2Of lymphoma,and
R18628 T23896 T23894 arg1Of lymphoma,LMP1
R18629 T23896 T23895 arg1Of lymphoma,transgenic
R18630 T23896 T23897 arg1Of lymphoma,1
R18631 T23898 T23899 arg1Of Arrows,indicate
R18632 T23898 T23906 arg1Of Arrows,β
R18633 T23899 T23905 arg1Of indicate,and
R18634 T23901 T23899 arg2Of positions,indicate
R18635 T23901 T23900 arg1Of positions,the
R18636 T23901 T23902 arg1Of positions,of
R18637 T23904 T23902 arg2Of α,of
R18638 T23904 T23903 arg1Of α,the
R18639 T23906 T23905 arg2Of β,and
R18640 T23907 T23906 arg2Of isoforms,β
R18641 T23907 T23908 arg1Of isoforms,of
R18642 T23909 T23908 arg2Of Stat3,of
R18643 T23910 T23911 arg1Of Actin,was
R18644 T23910 T23912 arg2Of Actin,used
R18645 T23912 T23911 arg2Of used,was
R18646 T23912 T23913 arg1Of used,as
R18647 T23916 T23913 arg2Of control,as
R18648 T23916 T23914 arg1Of control,a
R18649 T23916 T23915 arg1Of control,loading
R18650 T23918 T23917 arg2Of D,(
R18651 T23919 T23917 arg3Of ),(
R18652 T23921 T23917 arg1Of detection,(
R18653 T23921 T23920 arg1Of detection,Immunohistochemistry
R18654 T23921 T23922 arg1Of detection,of
R18655 T23921 T23926 arg1Of detection,in
R18656 T23925 T23922 arg2Of pStat3,of
R18657 T23925 T23923 arg2Of pStat3,activated
R18658 T23925 T23924 arg1Of pStat3,nuclear
R18659 T23928 T23926 arg2Of spleens,in
R18660 T23928 T23927 arg1Of spleens,the
R18661 T23928 T23929 arg1Of spleens,of
R18662 T23930 T23931 arg1Of WT,and
R18663 T23932 T23931 arg2Of LMP1,and
R18664 T23934 T23929 arg2Of mice,of
R18665 T23934 T23930 arg1Of mice,WT
R18666 T23934 T23932 arg1Of mice,LMP1
R18667 T23934 T23933 arg1Of mice,transgenic
R18668 T23936 T23935 arg1Of bar,Scale
R18669 T23936 T23937 arg1Of bar,","
R18670 T23939 T23937 arg2Of μm,","
R18671 T23939 T23938 arg1Of μm,20
R18940 T24376 T24377 arg1Of LMP1,Activates
R18941 T24376 T24381 arg1Of LMP1,Deregulates
R18942 T24377 T24380 arg1Of Activates,and
R18943 T24379 T24377 arg2Of Signaling,Activates
R18944 T24379 T24378 arg1Of Signaling,Akt
R18945 T24381 T24380 arg2Of Deregulates,and
R18946 T24386 T24381 arg2Of Pathway,Deregulates
R18947 T24386 T24382 arg1Of Pathway,the
R18948 T24386 T24383 arg1Of Pathway,Rb
R18949 T24386 T24384 arg1Of Pathway,Cell
R18950 T24386 T24385 arg1Of Pathway,Cycle
R18951 T24388 T24389 arg1Of A,and
R18952 T24389 T24401 arg1Of and,from
R18953 T24389 T24429 arg1Of and,and
R18954 T24393 T24389 arg2Of analysis,and
R18955 T24393 T24390 arg1Of analysis,B
R18956 T24393 T24391 arg1Of analysis,)
R18957 T24393 T24392 arg1Of analysis,Immunoblot
R18958 T24393 T24394 arg1Of analysis,of
R18959 T24397 T24394 arg2Of cells,of
R18960 T24397 T24395 arg2Of cells,purified
R18961 T24397 T24396 arg1Of cells,B
R18962 T24397 T24398 arg1Of cells,(
R18963 T24399 T24398 arg2Of CD19+,(
R18964 T24400 T24398 arg3Of ),(
R18965 T24403 T24401 arg2Of spleens,from
R18966 T24403 T24402 arg1Of spleens,the
R18967 T24403 T24404 arg1Of spleens,of
R18968 T24403 T24413 arg1Of spleens,","
R18969 T24403 T24414 arg1Of spleens,probing
R18970 T24403 T24424 arg1Of spleens,","
R18971 T24403 T24425 arg1Of spleens,including
R18972 T24405 T24406 arg1Of WT,and
R18973 T24406 T24404 arg2Of and,of
R18974 T24406 T24410 arg1Of and,for
R18975 T24409 T24406 arg2Of mice,and
R18976 T24409 T24407 arg1Of mice,LMP1
R18977 T24409 T24408 arg1Of mice,transgenic
R18978 T24412 T24410 arg2Of signaling,for
R18979 T24412 T24411 arg1Of signaling,Akt
R18980 T24414 T24415 arg1Of probing,for
R18981 T24417 T24416 arg2Of A,(
R18982 T24418 T24416 arg3Of ),(
R18983 T24420 T24416 arg1Of pAkt,(
R18984 T24420 T24419 arg2Of pAkt,activated
R18985 T24420 T24421 arg1Of pAkt,and
R18986 T24421 T24415 arg2Of and,for
R18987 T24423 T24421 arg2Of targets,and
R18988 T24423 T24422 arg1Of targets,downstream
R18989 T24427 T24425 arg2Of pGSK3α/β,including
R18990 T24427 T24426 arg2Of pGSK3α/β,inactivated
R18991 T24429 T24428 arg1Of and,","
R18992 T24429 T24433 arg1Of and,activated
R18993 T24431 T24429 arg2Of B,and
R18994 T24431 T24430 arg2Of B,(
R18995 T24432 T24430 arg3Of ),(
R18996 T24433 T24387 arg1Of activated,(
R18997 T24434 T24436 arg1Of p-mTOR,and
R18998 T24436 T24435 arg1Of and,","
R18999 T24437 T24436 arg2Of total,and
R19000 T24438 T24433 arg2Of levels,activated
R19001 T24438 T24434 arg1Of levels,p-mTOR
R19002 T24438 T24437 arg1Of levels,total
R19003 T24438 T24439 arg1Of levels,of
R19004 T24440 T24439 arg2Of FoxO1,of
R19005 T24441 T24442 arg1Of Arrows,indicate
R19006 T24441 T24448 arg1Of Arrows,β
R19007 T24442 T24447 arg1Of indicate,and
R19008 T24444 T24442 arg2Of positions,indicate
R19009 T24444 T24443 arg1Of positions,the
R19010 T24444 T24445 arg1Of positions,of
R19011 T24446 T24445 arg2Of α,of
R19012 T24448 T24447 arg2Of β,and
R19013 T24449 T24448 arg2Of isoforms,β
R19014 T24449 T24450 arg1Of isoforms,of
R19015 T24451 T24450 arg2Of GSK3,of
R19016 T24454 T24452 arg1Of line,The
R19017 T24454 T24453 arg1Of line,white
R19018 T24454 T24455 arg1Of line,indicates
R19019 T24458 T24457 arg1Of lanes,intervening
R19020 T24458 T24459 arg1Of lanes,have
R19021 T24458 T24460 arg1Of lanes,been
R19022 T24458 T24461 arg2Of lanes,spliced
R19023 T24461 T24455 arg2Of spliced,indicates
R19024 T24461 T24456 arg1Of spliced,that
R19025 T24461 T24459 arg2Of spliced,have
R19026 T24461 T24460 arg2Of spliced,been
R19027 T24461 T24462 arg1Of spliced,out
R19028 T24464 T24463 arg2Of C,(
R19029 T24465 T24463 arg3Of ),(
R19030 T24467 T24463 arg1Of analysis,(
R19031 T24467 T24466 arg1Of analysis,Immunoblot
R19032 T24467 T24468 arg1Of analysis,for
R19033 T24471 T24469 arg1Of proteins,cell
R19034 T24471 T24470 arg1Of proteins,cycle
R19035 T24471 T24472 arg1Of proteins,regulating
R19036 T24471 T24482 arg1Of proteins,and
R19037 T24472 T24476 arg1Of regulating,","
R19038 T24472 T24477 modOf regulating,probing
R19039 T24475 T24472 arg2Of pathway,regulating
R19040 T24475 T24473 arg1Of pathway,the
R19041 T24475 T24474 arg1Of pathway,Rb
R19042 T24477 T24478 arg1Of probing,for
R19043 T24480 T24478 arg2Of pRb,for
R19044 T24480 T24479 arg2Of pRb,activated
R19045 T24482 T24468 arg2Of and,for
R19046 T24482 T24481 arg1Of and,","
R19047 T24484 T24482 arg2Of levels,and
R19048 T24484 T24483 arg1Of levels,total
R19049 T24484 T24485 arg1Of levels,of
R19050 T24486 T24487 arg1Of Cdk2,and
R19051 T24490 T24487 arg2Of inhibitor,and
R19052 T24490 T24488 arg1Of inhibitor,the
R19053 T24490 T24489 arg1Of inhibitor,Cdk
R19054 T24491 T24485 arg2Of p27,of
R19055 T24491 T24486 arg1Of p27,Cdk2
R19056 T24491 T24490 arg1Of p27,inhibitor
R19057 T24492 T24493 arg1Of Actin,was
R19058 T24492 T24494 arg2Of Actin,used
R19059 T24494 T24493 arg2Of used,was
R19060 T24494 T24495 arg1Of used,as
R19061 T24498 T24495 arg2Of control,as
R19062 T24498 T24496 arg1Of control,a
R19063 T24498 T24497 arg1Of control,loading
R19229 T24804 T24805 arg1Of Akt,","
R19230 T24805 T24808 arg1Of ",",and
R19231 T24806 T24805 arg2Of NFκB,","
R19232 T24808 T24807 arg1Of and,","
R19233 T24808 T24811 arg1Of and,Are
R19234 T24808 T24812 arg2Of and,Required
R19235 T24810 T24808 arg2Of Signaling,and
R19236 T24810 T24809 arg1Of Signaling,Stat3
R19237 T24812 T24811 arg2Of Required,Are
R19238 T24812 T24813 arg1Of Required,for
R19239 T24815 T24816 arg1Of Growth,and
R19240 T24816 T24813 arg2Of and,for
R19241 T24816 T24814 arg1Of and,the
R19242 T24816 T24818 arg1Of and,of
R19243 T24817 T24816 arg2Of Survival,and
R19244 T24820 T24818 arg2Of Cells,of
R19245 T24820 T24819 arg1Of Cells,Lymphoma
R19246 T24822 T24821 arg1Of assay,MTS
R19247 T24822 T24823 arg1Of assay,of
R19248 T24822 T24832 arg1Of assay,or
R19249 T24824 T24823 arg2Of splenocytes,of
R19250 T24824 T24825 arg1Of splenocytes,from
R19251 T24827 T24828 arg1Of A,and
R19252 T24828 T24826 arg2Of and,(
R19253 T24829 T24828 arg2Of B,and
R19254 T24830 T24826 arg3Of ),(
R19255 T24831 T24825 arg2Of WT,from
R19256 T24831 T24826 arg1Of WT,(
R19257 T24834 T24835 arg1Of C,and
R19258 T24835 T24833 arg2Of and,(
R19259 T24836 T24835 arg2Of D,and
R19260 T24837 T24833 arg3Of ),(
R19261 T24840 T24833 arg1Of lymphomas,(
R19262 T24840 T24838 arg1Of lymphomas,LMP1
R19263 T24840 T24839 arg1Of lymphomas,transgenic
R19264 T24840 T24841 arg1Of lymphomas,and
R19265 T24841 T24832 arg2Of and,or
R19266 T24843 T24844 arg1Of E,and
R19267 T24844 T24842 arg2Of and,(
R19268 T24845 T24844 arg2Of F,and
R19269 T24846 T24842 arg3Of ),(
R19270 T24849 T24841 arg2Of lymphoctyes,and
R19271 T24849 T24842 arg1Of lymphoctyes,(
R19272 T24849 T24847 arg1Of lymphoctyes,LMP1
R19273 T24849 T24848 arg1Of lymphoctyes,transgenic
R19274 T24850 T24851 arg1Of Splenocytes,were
R19275 T24850 T24852 arg2Of Splenocytes,cultured
R19276 T24852 T24851 arg2Of cultured,were
R19277 T24852 T24853 arg1Of cultured,with
R19278 T24852 T24855 arg1Of cultured,without
R19279 T24853 T24854 arg1Of with,or
R19280 T24855 T24854 arg2Of without,or
R19281 T24856 T24853 arg2Of inhibitors,with
R19282 T24856 T24855 arg2Of inhibitors,without
R19283 T24856 T24857 arg1Of inhibitors,of
R19284 T24858 T24859 arg1Of NFκB,(
R19285 T24858 T24862 arg1Of NFκB,","
R19286 T24860 T24859 arg2Of BAY11,(
R19287 T24861 T24859 arg3Of ),(
R19288 T24862 T24867 arg1Of ",",","
R19289 T24863 T24862 arg2Of mTOR,","
R19290 T24863 T24864 arg1Of mTOR,(
R19291 T24865 T24864 arg2Of rapamycin,(
R19292 T24866 T24864 arg3Of ),(
R19293 T24867 T24872 arg1Of ",",","
R19294 T24868 T24867 arg2Of Akt,","
R19295 T24868 T24869 arg1Of Akt,(
R19296 T24870 T24869 arg2Of triciribine,(
R19297 T24871 T24869 arg3Of ),(
R19298 T24872 T24857 arg2Of ",",of
R19299 T24873 T24874 arg1Of MEK1/2,(
R19300 T24873 T24877 arg1Of MEK1/2,","
R19301 T24875 T24874 arg2Of U0126,(
R19302 T24876 T24874 arg3Of ),(
R19303 T24877 T24883 arg1Of ",",or
R19304 T24878 T24877 arg2Of p38,","
R19305 T24878 T24879 arg1Of p38,(
R19306 T24880 T24879 arg2Of SB202190,(
R19307 T24881 T24879 arg3Of ),(
R19308 T24883 T24872 arg2Of or,","
R19309 T24883 T24882 arg1Of or,","
R19310 T24884 T24883 arg2Of Stat3,or
R19311 T24884 T24885 arg1Of Stat3,(
R19312 T24884 T24891 arg1Of Stat3,at
R19313 T24886 T24887 arg1Of cucurbitacin,I
R19314 T24886 T24888 arg1Of cucurbitacin,and
R19315 T24888 T24885 arg2Of and,(
R19316 T24889 T24888 arg2Of AG490,and
R19317 T24890 T24885 arg3Of ),(
R19318 T24894 T24891 arg2Of concentrations,at
R19319 T24894 T24892 arg1Of concentrations,the
R19320 T24894 T24893 arg2Of concentrations,indicated
R19321 T24896 T24895 arg1Of results,The
R19322 T24896 T24897 arg1Of results,are
R19323 T24901 T24897 arg2Of SEM,are
R19324 T24901 T24898 arg1Of SEM,the
R19325 T24901 T24899 arg1Of SEM,mean
R19326 T24901 T24900 arg1Of SEM,±
R19327 T24901 T24902 arg1Of SEM,of
R19328 T24904 T24902 arg2Of samples,of
R19329 T24904 T24903 arg1Of samples,triplicate
R19330 T24906 T24905 modOf are,Shown
R19331 T24908 T24905 arg2Of results,Shown
R19332 T24908 T24906 arg1Of results,are
R19333 T24908 T24907 arg1Of results,the
R19334 T24908 T24909 arg1Of results,for
R19335 T24911 T24912 arg1Of A,and
R19336 T24912 T24910 arg2Of and,(
R19337 T24913 T24912 arg2Of B,and
R19338 T24914 T24910 arg3Of ),(
R19339 T24916 T24910 arg1Of lymphoma,(
R19340 T24916 T24915 arg1Of lymphoma,WT
R19341 T24916 T24917 arg1Of lymphoma,1
R19342 T24916 T24918 arg1Of lymphoma,","
R19343 T24918 T24929 arg1Of ",",and
R19344 T24920 T24921 arg1Of C,and
R19345 T24921 T24919 arg2Of and,(
R19346 T24922 T24921 arg2Of D,and
R19347 T24923 T24919 arg3Of ),(
R19348 T24926 T24918 arg2Of lymphoma,","
R19349 T24926 T24919 arg1Of lymphoma,(
R19350 T24926 T24924 arg1Of lymphoma,LMP1
R19351 T24926 T24925 arg1Of lymphoma,transgenic
R19352 T24926 T24927 arg1Of lymphoma,2
R19353 T24929 T24909 arg2Of and,for
R19354 T24929 T24928 arg1Of and,","
R19355 T24929 T24935 arg1Of and,one
R19356 T24931 T24932 arg1Of E,and
R19357 T24932 T24929 arg2Of and,and
R19358 T24932 T24930 arg2Of and,(
R19359 T24933 T24932 arg2Of F,and
R19360 T24934 T24930 arg3Of ),(
R19361 T24935 T24936 arg1Of one,out
R19362 T24941 T24936 arg2Of mice,out
R19363 T24941 T24937 arg1Of mice,of
R19364 T24941 T24938 arg1Of mice,two
R19365 T24941 T24939 arg1Of mice,LMP1
R19366 T24941 T24940 arg1Of mice,transgenic
R19367 T24941 T24942 arg2Of mice,analyzed
R19368 T24944 T24943 arg1Of analysis,This
R19369 T24944 T24945 arg1Of analysis,was
R19370 T24944 T24946 arg2Of analysis,repeated
R19371 T24946 T24945 arg2Of repeated,was
R19372 T24946 T24947 arg1Of repeated,with
R19373 T24954 T24947 arg2Of results,with
R19374 T24954 T24948 arg1Of results,LMP1
R19375 T24954 T24949 arg1Of results,transgenic
R19376 T24954 T24950 arg1Of results,lymphoma
R19377 T24954 T24951 arg1Of results,4
R19378 T24954 T24952 arg1Of results,yielding
R19379 T24954 T24953 arg1Of results,similar
R19563 T25244 T25245 arg1Of Analysis,of
R19564 T25244 T25253 arg1Of Analysis,in
R19565 T25246 T25247 arg1Of Akt,","
R19566 T25247 T25250 arg1Of ",",and
R19567 T25248 T25247 arg2Of NFκB,","
R19568 T25250 T25245 arg2Of and,of
R19569 T25250 T25249 arg1Of and,","
R19570 T25252 T25250 arg2Of Pathways,and
R19571 T25252 T25251 arg1Of Pathways,Stat3
R19572 T25254 T25253 arg2Of Contribution,in
R19573 T25254 T25255 arg1Of Contribution,to
R19574 T25257 T25258 arg1Of Growth,and
R19575 T25258 T25255 arg2Of and,to
R19576 T25258 T25256 arg1Of and,the
R19577 T25258 T25260 arg1Of and,of
R19578 T25259 T25258 arg2Of Survival,and
R19579 T25262 T25260 arg2Of Cells,of
R19580 T25262 T25261 arg1Of Cells,Lymphoma
R19581 T25264 T25263 arg2Of A–D,(
R19582 T25265 T25263 arg3Of ),(
R19583 T25267 T25263 arg1Of analysis,(
R19584 T25267 T25266 arg1Of analysis,Immunoblot
R19585 T25267 T25268 arg1Of analysis,of
R19586 T25267 T25274 arg1Of analysis,for
R19587 T25267 T25282 arg1Of analysis,after
R19588 T25267 T25312 arg1Of analysis,and
R19589 T25269 T25270 arg1Of wild-type,and
R19590 T25270 T25268 arg2Of and,of
R19591 T25273 T25270 arg2Of lymphomas,and
R19592 T25273 T25271 arg1Of lymphomas,LMP1
R19593 T25273 T25272 arg1Of lymphomas,transgenic
R19594 T25275 T25276 arg1Of Akt,","
R19595 T25276 T25279 arg1Of ",",and
R19596 T25277 T25276 arg2Of NFκB,","
R19597 T25279 T25274 arg2Of and,for
R19598 T25279 T25278 arg1Of and,","
R19599 T25281 T25279 arg2Of signaling,and
R19600 T25281 T25280 arg1Of signaling,Stat3
R19601 T25283 T25284 arg1Of treatment,with
R19602 T25283 T25293 arg1Of treatment,","
R19603 T25284 T25285 arg1Of with,(
R19604 T25286 T25285 arg2Of A,(
R19605 T25287 T25285 arg3Of ),(
R19606 T25290 T25284 arg2Of inhibitor,with
R19607 T25290 T25288 arg1Of inhibitor,an
R19608 T25290 T25289 arg1Of inhibitor,Akt
R19609 T25290 T25291 arg1Of inhibitor,","
R19610 T25292 T25291 arg2Of triciribine,","
R19611 T25293 T25300 arg1Of ",",","
R19612 T25293 T25303 arg1Of ",",and
R19613 T25295 T25294 arg2Of B,(
R19614 T25295 T25298 arg1Of B,NFκB
R19615 T25296 T25294 arg3Of ),(
R19616 T25298 T25297 arg1Of NFκB,an
R19617 T25299 T25293 arg2Of inhibitor,","
R19618 T25299 T25294 arg1Of inhibitor,(
R19619 T25301 T25300 arg2Of BAY11–7085,","
R19620 T25303 T25282 arg2Of and,after
R19621 T25303 T25302 arg1Of and,","
R19622 T25306 T25305 arg1Of inhibitors,Stat3
R19623 T25306 T25307 arg1Of inhibitors,(
R19624 T25308 T25307 arg2Of C,(
R19625 T25309 T25307 arg3Of ),(
R19626 T25310 T25303 arg2Of cucurbitacin,and
R19627 T25310 T25304 arg1Of cucurbitacin,the
R19628 T25310 T25306 arg1Of cucurbitacin,inhibitors
R19629 T25310 T25311 arg1Of cucurbitacin,I
R19630 T25312 T25317 arg1Of and,","
R19631 T25312 T25318 arg1Of and,at
R19632 T25314 T25313 arg2Of D,(
R19633 T25315 T25313 arg3Of ),(
R19634 T25316 T25312 arg2Of AG490,and
R19635 T25316 T25313 arg1Of AG490,(
R19636 T25321 T25318 arg2Of concentrations,at
R19637 T25321 T25319 arg1Of concentrations,the
R19638 T25321 T25320 arg2Of concentrations,indicated
R19639 T25322 T25323 arg1Of Arrows,indicate
R19640 T25322 T25329 arg1Of Arrows,β
R19641 T25323 T25328 arg1Of indicate,and
R19642 T25325 T25323 arg2Of positions,indicate
R19643 T25325 T25324 arg1Of positions,the
R19644 T25325 T25326 arg1Of positions,of
R19645 T25327 T25326 arg2Of α,of
R19646 T25329 T25328 arg2Of β,and
R19647 T25330 T25329 arg2Of isoforms,β
R19648 T25330 T25331 arg1Of isoforms,of
R19649 T25332 T25331 arg2Of Stat3,of
R19650 T25333 T25334 arg1Of Actin,was
R19651 T25333 T25335 arg2Of Actin,used
R19652 T25335 T25334 arg2Of used,was
R19653 T25335 T25336 arg1Of used,as
R19654 T25339 T25336 arg2Of control,as
R19655 T25339 T25337 arg1Of control,a
R19656 T25339 T25338 arg1Of control,loading
R3150 T4123 T4128 arg1Of Lymphomas,Exclusion
R3157 T4130 T4129 arg1Of determine,To
R3196 T4171 T4129 modOf analyzed,To
R7399 T9834 T9829 arg2Of Pathway,Deregulates
R7400 T9834 T9830 arg1Of Pathway,the
R7401 T9834 T9831 arg1Of Pathway,Rb
R7402 T9834 T9832 arg1Of Pathway,Cell
R16492 T21043 T21042 arg1Of assay,radioimmunoprecipitation
R16493 T21043 T21044 arg1Of assay,(
R18470 T23741 T23747 arg1Of LMP1,Activates
R18472 T23742 T23745 arg1Of Upregulates,and
R18473 T23744 T23743 arg1Of Expression,IL10
R18475 T23747 T23745 arg2Of Activates,and
R3149 T4120 T4121 arg1Of LMP1,Promotes
R3151 T4123 T4121 arg2Of Lymphomas,Promotes
R3152 T4123 T4122 arg1Of Lymphomas,B-1a
R3153 T4123 T4124 arg1Of Lymphomas,That
R3154 T4123 T4125 arg1Of Lymphomas,Can
R3155 T4128 T4126 arg1Of Exclusion,Escape
R3156 T4128 T4127 arg1Of Exclusion,Allelic
R3158 T4130 T4138 arg1Of determine,and
R3159 T4133 T4132 arg1Of signaling,LMP1
R3160 T4133 T4134 arg1Of signaling,affects
R3161 T4134 T4130 arg2Of affects,determine
R3162 T4134 T4131 arg1Of affects,if
R3163 T4137 T4134 arg2Of differentiation,affects
R3164 T4137 T4135 arg1Of differentiation,B
R3165 T4137 T4136 arg1Of differentiation,cell
R3166 T4140 T4138 arg2Of immunophenotype,and
R3167 T4140 T4139 arg1Of immunophenotype,to
R3197 T4171 T4139 modOf analyzed,to
R16322 T20847 T20875 arg1Of were,","
R16323 T20847 T20876 modOf were,followed
R16328 T20853 T20862 arg1Of ",",","
R16334 T20858 T20859 arg1Of °C,for
R16335 T20861 T20859 arg2Of s,for
R16336 T20861 T20860 arg1Of s,30
R16337 T20862 T20869 arg1Of ",",and
R16338 T20864 T20862 arg2Of °C,","
R16339 T20864 T20863 arg1Of °C,63
R16340 T20864 T20865 arg1Of °C,for
R16341 T20867 T20865 arg2Of s,for
R16342 T20867 T20866 arg1Of s,90
R16344 T20869 T20868 arg1Of and,","
R16345 T20871 T20869 arg2Of °C,and
R16346 T20871 T20870 arg1Of °C,72
R16347 T20871 T20872 arg1Of °C,for
R16348 T20874 T20872 arg2Of min,for
R16349 T20874 T20873 arg1Of min,1
R16350 T20879 T20876 arg1Of cycle,followed
R16351 T20879 T20877 arg2Of cycle,by
R16352 T20879 T20878 arg1Of cycle,1
R16353 T20879 T20880 arg1Of cycle,of
R16354 T20882 T20880 arg2Of °C,of
R16355 T20882 T20881 arg1Of °C,72
R16356 T20882 T20883 arg1Of °C,for
R16357 T20885 T20883 arg2Of min,for
R16358 T20885 T20884 arg1Of min,5
R19769 T25510 T25511 arg1Of Summary,of
R19770 T25510 T25514 arg1Of Summary,on
R19771 T25513 T25511 arg2Of Performed,of
R19772 T25513 T25512 arg1Of Performed,Analysis
R19773 T25515 T25516 arg1Of Wild-Type,and
R19774 T25516 T25514 arg2Of and,on
R19775 T25519 T25516 arg2Of Lymphomas,and
R19776 T25519 T25517 arg1Of Lymphomas,LMP1
R19777 T25519 T25518 arg1Of Lymphomas,Transgenic

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T229 761-779 Anaphor denotes These same targets
T230 658-661 Antecedent denotes IL4
T231 662-667 Antecedent denotes Stat6
T232 744-749 Antecedent denotes Stat3
T1701 2721-2723 Anaphor denotes it
T1702 2641-2666 Antecedent denotes Latent membrane protein 1
T1703 6354-6370 Anaphor denotes the same targets
T1704 6141-6144 Antecedent denotes Akt
T1705 6156-6161 Antecedent denotes Stat3
T12659 32578-32589 Anaphor denotes all protein
T12660 32501-32504 Antecedent denotes Akt
T12661 32506-32511 Antecedent denotes Stat3
T12662 32523-32527 Antecedent denotes IκBα
T8189 20078-20098 Anaphor denotes the tested cytokines
T8190 19906-19909 Antecedent denotes IL4
T8191 19911-19914 Antecedent denotes IL5
T8192 19916-19920 Antecedent denotes IL10
T8193 19922-19926 Antecedent denotes IL13
T8194 19928-19932 Antecedent denotes IL15
T8195 19934-19937 Antecedent denotes IL9
T8196 19939-19942 Antecedent denotes IL2
T8197 19944-19947 Antecedent denotes IL6
T8198 19953-19957 Antecedent denotes IFNγ
T8199 22668-22670 Anaphor denotes it
T8200 22656-22666 Antecedent denotes activation
T10393 26570-26582 Anaphor denotes this pathway
T10394 26469-26478 Antecedent denotes Activated
T15998 39256-39271 Anaphor denotes NFκB components
T15999 39280-39284 Antecedent denotes cRel
T16000 41259-41263 Anaphor denotes this
T16001 41175-41180 Antecedent denotes Fox01
T16002 41287-41309 Anaphor denotes other Forkhead targets
T16003 41354-41357 Antecedent denotes p27
T16004 41362-41370 Antecedent denotes CyclinD2
R355 T229 T230 boundBy These same targets,IL4
R356 T229 T231 boundBy These same targets,Stat6
R357 T229 T232 boundBy These same targets,Stat3
R1298 T1701 T1702 boundBy it,Latent membrane protein 1
R1300 T1703 T1704 boundBy the same targets,Akt
R1301 T1703 T1705 boundBy the same targets,Stat3
R9668 T12659 T12660 boundBy all protein,Akt
R9669 T12659 T12661 boundBy all protein,Stat3
R9670 T12659 T12662 boundBy all protein,IκBα
R6350 T8189 T8192 boundBy the tested cytokines,IL10
R6351 T8189 T8193 boundBy the tested cytokines,IL13
R6352 T8189 T8194 boundBy the tested cytokines,IL15
R6353 T8189 T8195 boundBy the tested cytokines,IL9
R6354 T8189 T8196 boundBy the tested cytokines,IL2
R6348 T8189 T8190 boundBy the tested cytokines,IL4
R6349 T8189 T8191 boundBy the tested cytokines,IL5
R6355 T8189 T8197 boundBy the tested cytokines,IL6
R6356 T8189 T8198 boundBy the tested cytokines,IFNγ
R6357 T8199 T8200 boundBy it,activation
R7981 T10393 T10394 boundBy this pathway,Activated
R12292 T15998 T15999 boundBy NFκB components,cRel
R12293 T16000 T16001 boundBy this,Fox01
R12294 T16002 T16003 boundBy other Forkhead targets,p27
R12295 T16002 T16004 boundBy other Forkhead targets,CyclinD2

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T255 11-19 NNP denotes Membrane
T256 20-27 NNP denotes Protein
T257 28-29 CD denotes 1
T258 30-39 NNP denotes Activates
T259 40-43 NNP denotes Akt
T260 43-44 , denotes ,
T261 45-49 NNP denotes NFκB
T262 49-50 , denotes ,
T263 51-54 CC denotes and
T264 55-60 NNP denotes Stat3
T265 61-63 IN denotes in
T266 64-65 NNP denotes B
T267 66-70 NNP denotes Cell
T268 71-80 NNP denotes Lymphomas
T269 141-147 NNP denotes Latent
T270 148-156 NN denotes membrane
T271 157-164 NN denotes protein
T272 165-166 CD denotes 1
T273 167-168 -LRB- denotes (
T274 168-172 CD denotes LMP1
T275 172-173 -RRB- denotes )
T276 174-176 VBZ denotes is
T277 177-180 DT denotes the
T278 181-186 JJ denotes major
T279 187-198 NN denotes oncoprotein
T280 199-201 IN denotes of
T281 202-214 NNP denotes Epstein-Barr
T282 215-220 NN denotes virus
T283 221-222 -LRB- denotes (
T284 222-225 NNP denotes EBV
T285 225-226 -RRB- denotes )
T286 226-227 . denotes .
T287 228-230 IN denotes In
T288 231-241 JJ denotes transgenic
T289 242-246 NNS denotes mice
T290 246-247 , denotes ,
T291 248-252 NNP denotes LMP1
T292 253-261 VBZ denotes promotes
T293 262-271 VBN denotes increased
T294 272-280 NN denotes lymphoma
T295 281-292 NN denotes development
T296 293-295 IN denotes by
T297 296-298 CD denotes 12
T298 299-301 NN denotes mo
T299 302-304 IN denotes of
T300 305-308 NN denotes age
T301 308-309 . denotes .
T302 310-314 DT denotes This
T303 315-320 NN denotes study
T304 321-328 VBZ denotes reveals
T305 329-333 IN denotes that
T306 334-342 NN denotes lymphoma
T307 343-351 VBZ denotes develops
T308 352-354 IN denotes in
T309 355-359 NN denotes B-1a
T310 360-371 NNS denotes lymphocytes
T311 371-372 , denotes ,
T312 373-374 DT denotes a
T313 375-385 NN denotes population
T314 386-390 WDT denotes that
T315 391-393 VBZ denotes is
T316 394-404 VBN denotes associated
T317 405-409 IN denotes with
T318 410-424 NN denotes transformation
T319 425-427 IN denotes in
T320 428-433 JJR denotes older
T321 434-438 NNS denotes mice
T322 438-439 . denotes .
T323 440-443 DT denotes The
T324 444-452 NN denotes lymphoma
T325 453-458 NNS denotes cells
T326 459-463 VBP denotes have
T327 464-475 VBN denotes deregulated
T328 476-480 NN denotes cell
T329 481-486 NN denotes cycle
T330 487-494 NNS denotes markers
T331 494-495 , denotes ,
T332 496-499 CC denotes and
T333 500-510 NNS denotes inhibitors
T334 511-513 IN denotes of
T335 514-517 NNP denotes Akt
T336 517-518 , denotes ,
T337 519-523 NNP denotes NFκB
T338 523-524 , denotes ,
T339 525-528 CC denotes and
T340 529-534 JJ denotes Stat3
T341 535-540 NN denotes block
T342 541-544 DT denotes the
T343 545-553 JJ denotes enhanced
T344 554-563 NN denotes viability
T345 564-566 IN denotes of
T346 567-571 CD denotes LMP1
T347 572-582 JJ denotes transgenic
T348 583-594 NNS denotes lymphocytes
T349 595-598 CC denotes and
T350 599-607 NN denotes lymphoma
T351 608-613 NNS denotes cells
T352 614-616 IN denotes in
T353 617-622 NN denotes vitro
T354 622-623 . denotes .
T355 624-632 NNP denotes Lymphoma
T356 633-638 NNS denotes cells
T357 639-642 VBP denotes are
T358 643-654 JJ denotes independent
T359 655-657 IN denotes of
T360 658-667 NNP denotes IL4/Stat6
T361 668-677 VBG denotes signaling
T362 678-681 IN denotes for
T363 682-690 NN denotes survival
T364 691-694 CC denotes and
T365 695-708 NN denotes proliferation
T366 708-709 , denotes ,
T367 710-713 CC denotes but
T368 714-718 VBP denotes have
T369 719-733 RB denotes constitutively
T370 734-743 VBN denotes activated
T371 744-749 JJ denotes Stat3
T372 750-759 VBG denotes signaling
T373 759-760 . denotes .
T374 761-766 DT denotes These
T375 767-771 JJ denotes same
T376 772-779 NNS denotes targets
T377 780-783 VBP denotes are
T378 784-788 RB denotes also
T379 789-800 VBN denotes deregulated
T380 801-803 IN denotes in
T381 804-813 JJ denotes wild-type
T382 814-818 NN denotes B-1a
T383 819-828 NNS denotes lymphomas
T384 829-833 WDT denotes that
T385 834-839 VBP denotes arise
T386 840-853 RB denotes spontaneously
T387 854-861 IN denotes through
T388 862-865 NN denotes age
T389 866-880 NN denotes predisposition
T390 880-881 . denotes .
T391 882-887 DT denotes These
T392 888-895 NNS denotes results
T393 896-903 VBP denotes suggest
T394 904-908 IN denotes that
T395 909-912 NNP denotes Akt
T396 912-913 , denotes ,
T397 914-918 NNP denotes NFκB
T398 918-919 , denotes ,
T399 920-923 CC denotes and
T400 924-929 JJ denotes Stat3
T401 930-938 NNS denotes pathways
T402 939-942 MD denotes may
T403 943-948 VB denotes serve
T404 949-951 IN denotes as
T405 952-961 JJ denotes effective
T406 962-969 NNS denotes targets
T407 970-972 IN denotes in
T408 973-976 DT denotes the
T409 977-986 NN denotes treatment
T410 987-989 IN denotes of
T411 990-1004 JJ denotes EBV-associated
T412 1005-1006 NNP denotes B
T413 1007-1011 NN denotes cell
T414 1012-1021 NNS denotes lymphomas
T415 1021-1022 . denotes .
T1774 1750-1762 NNP denotes Epstein-Barr
T1775 1763-1768 NN denotes virus
T1776 1769-1770 -LRB- denotes (
T1777 1770-1773 NNP denotes EBV
T1778 1773-1774 -RRB- denotes )
T1779 1775-1777 VBZ denotes is
T1780 1778-1779 DT denotes a
T1781 1780-1790 JJ denotes ubiquitous
T1782 1791-1804 NN denotes γ-herpesvirus
T1783 1805-1809 WDT denotes that
T1784 1810-1817 VBZ denotes infects
T1785 1818-1824 NNS denotes humans
T1786 1825-1838 RB denotes predominantly
T1787 1839-1841 IN denotes at
T1788 1842-1844 DT denotes an
T1789 1845-1850 JJ denotes early
T1790 1851-1854 NN denotes age
T1791 1855-1859 IN denotes with
T1792 1860-1867 JJR denotes greater
T1793 1868-1872 IN denotes than
T1794 1873-1875 CD denotes 90
T1795 1875-1876 NN denotes %
T1796 1877-1879 IN denotes of
T1797 1880-1883 DT denotes the
T1798 1884-1889 NN denotes adult
T1799 1890-1900 NN denotes population
T1800 1901-1909 VBN denotes infected
T1801 1910-1914 IN denotes with
T1802 1915-1918 NNP denotes EBV
T1803 1919-1920 NNP denotes [
T1804 1920-1921 CD denotes 1
T1805 1921-1922 NNP denotes ]
T1806 1922-1923 . denotes .
T1807 1924-1927 NNP denotes EBV
T1808 1928-1930 VBZ denotes is
T1809 1931-1937 VBN denotes linked
T1810 1938-1940 TO denotes to
T1811 1941-1944 DT denotes the
T1812 1945-1956 NN denotes development
T1813 1957-1959 IN denotes of
T1814 1960-1964 DT denotes both
T1815 1965-1966 NNP denotes B
T1816 1967-1977 NN denotes lymphocyte
T1817 1978-1981 CC denotes and
T1818 1982-1992 JJ denotes epithelial
T1819 1993-1997 NN denotes cell
T1820 1998-2010 NNS denotes malignancies
T1821 2010-2011 , denotes ,
T1822 2012-2021 VBG denotes including
T1823 2022-2029 NNP denotes Burkitt
T1824 2030-2038 NN denotes lymphoma
T1825 2038-2039 , denotes ,
T1826 2040-2047 NNP denotes Hodgkin
T1827 2048-2055 NN denotes disease
T1828 2056-2057 -LRB- denotes (
T1829 2057-2059 NNP denotes HD
T1830 2059-2060 -RRB- denotes )
T1831 2060-2061 , denotes ,
T1832 2062-2065 CC denotes and
T1833 2066-2080 JJ denotes nasopharyngeal
T1834 2081-2090 NN denotes carcinoma
T1835 2091-2092 -LRB- denotes (
T1836 2092-2095 NNP denotes NPC
T1837 2095-2096 -RRB- denotes )
T1838 2096-2097 , denotes ,
T1839 2098-2101 CC denotes and
T1840 2102-2109 NNS denotes cancers
T1841 2110-2116 VBN denotes linked
T1842 2117-2119 TO denotes to
T1843 2120-2137 NN denotes immunosuppression
T1844 2137-2138 , denotes ,
T1845 2139-2148 VBG denotes including
T1846 2149-2164 JJ denotes post-transplant
T1847 2165-2173 NN denotes lymphoma
T1848 2174-2177 CC denotes and
T1849 2178-2193 JJ denotes AIDS-associated
T1850 2194-2203 NNS denotes lymphomas
T1851 2204-2205 NNP denotes [
T1852 2205-2208 CD denotes 2,3
T1853 2208-2209 NNP denotes ]
T1854 2209-2210 . denotes .
T1855 2211-2213 IN denotes In
T1856 2214-2219 NN denotes vitro
T1857 2220-2229 NN denotes infection
T1858 2230-2232 IN denotes of
T1859 2233-2234 NNP denotes B
T1860 2235-2246 NNS denotes lymphocytes
T1861 2247-2251 IN denotes with
T1862 2252-2255 NNP denotes EBV
T1863 2256-2263 VBZ denotes induces
T1864 2264-2273 JJ denotes permanent
T1865 2274-2280 NN denotes growth
T1866 2281-2295 NN denotes transformation
T1867 2295-2296 , denotes ,
T1868 2297-2300 CC denotes and
T1869 2301-2305 DT denotes this
T1870 2306-2313 NN denotes ability
T1871 2314-2316 TO denotes to
T1872 2317-2323 VB denotes affect
T1873 2324-2328 NN denotes cell
T1874 2329-2335 NN denotes growth
T1875 2336-2346 NN denotes regulation
T1876 2347-2353 JJ denotes likely
T1877 2354-2365 VBZ denotes contributes
T1878 2366-2368 TO denotes to
T1879 2369-2372 DT denotes the
T1880 2373-2384 NN denotes development
T1881 2385-2387 IN denotes of
T1882 2388-2394 NN denotes cancer
T1883 2394-2395 . denotes .
T1884 2396-2400 JJ denotes Many
T1885 2401-2403 IN denotes of
T1886 2404-2407 DT denotes the
T1887 2408-2413 JJ denotes viral
T1888 2414-2422 NNS denotes proteins
T1889 2423-2432 VBN denotes expressed
T1890 2433-2435 IN denotes in
T1891 2436-2447 VBN denotes transformed
T1892 2448-2453 NNS denotes cells
T1893 2453-2454 , denotes ,
T1894 2455-2464 VBG denotes including
T1895 2465-2468 DT denotes the
T1896 2469-2472 NNP denotes EBV
T1897 2473-2480 JJ denotes nuclear
T1898 2481-2489 NNS denotes antigens
T1899 2490-2493 CC denotes and
T1900 2494-2500 NN denotes latent
T1901 2501-2509 NN denotes membrane
T1902 2510-2518 NNS denotes proteins
T1903 2518-2519 , denotes ,
T1904 2520-2524 VBP denotes have
T1905 2525-2533 JJ denotes profound
T1906 2534-2541 NNS denotes effects
T1907 2542-2544 IN denotes on
T1908 2545-2549 NN denotes cell
T1909 2550-2556 NN denotes growth
T1910 2557-2567 NN denotes regulation
T1911 2568-2571 CC denotes and
T1912 2572-2575 VBP denotes are
T1913 2576-2584 VBN denotes required
T1914 2585-2588 IN denotes for
T1915 2589-2592 NNP denotes EBV
T1916 2593-2599 NN denotes latent
T1917 2600-2609 NN denotes infection
T1918 2610-2613 CC denotes and
T1919 2614-2615 NNP denotes B
T1920 2616-2620 NN denotes cell
T1921 2621-2635 NN denotes transformation
T1922 2636-2637 NNP denotes [
T1923 2637-2638 CD denotes 1
T1924 2638-2639 NNP denotes ]
T1925 2639-2640 . denotes .
T1926 2641-2647 NN denotes Latent
T1927 2648-2656 NN denotes membrane
T1928 2657-2664 NN denotes protein
T1929 2665-2666 CD denotes 1
T1930 2667-2668 -LRB- denotes (
T1931 2668-2672 CD denotes LMP1
T1932 2672-2673 -RRB- denotes )
T1933 2674-2676 VBZ denotes is
T1934 2677-2687 VBN denotes considered
T1935 2688-2691 DT denotes the
T1936 2692-2697 JJ denotes major
T1937 2698-2709 NN denotes oncoprotein
T1938 2710-2712 IN denotes of
T1939 2713-2716 NNP denotes EBV
T1940 2716-2717 , denotes ,
T1941 2718-2720 IN denotes as
T1942 2721-2723 PRP denotes it
T1943 2724-2734 VBZ denotes transforms
T1944 2735-2741 JJ denotes rodent
T1945 2742-2753 NNS denotes fibroblasts
T1946 2754-2756 TO denotes to
T1947 2757-2771 NN denotes tumorigenicity
T1948 2772-2774 IN denotes in
T1949 2775-2779 JJ denotes nude
T1950 2780-2784 NNS denotes mice
T1951 2785-2788 CC denotes and
T1952 2789-2791 VBZ denotes is
T1953 2792-2801 VBN denotes expressed
T1954 2802-2804 IN denotes in
T1955 2805-2807 NNP denotes HD
T1956 2807-2808 , denotes ,
T1957 2809-2812 NNP denotes NPC
T1958 2812-2813 , denotes ,
T1959 2814-2817 CC denotes and
T1960 2818-2846 JJ denotes immunosuppression-associated
T1961 2847-2853 NNS denotes tumors
T1962 2854-2855 VBP denotes [
T1963 2855-2856 CD denotes 4
T1964 2857-2858 CD denotes 8
T1965 2858-2859 NNP denotes ]
T1966 2859-2860 . denotes .
T1967 2861-2863 IN denotes In
T1968 2864-2865 NNP denotes B
T1969 2866-2877 NNS denotes lymphocytes
T1970 2877-2878 , denotes ,
T1971 2879-2883 NNP denotes LMP1
T1972 2884-2890 NNS denotes mimics
T1973 2891-2895 NNP denotes CD40
T1974 2896-2905 VBG denotes signaling
T1975 2905-2906 , denotes ,
T1976 2907-2910 CC denotes and
T1977 2911-2915 DT denotes both
T1978 2916-2920 CD denotes LMP1
T1979 2921-2924 CC denotes and
T1980 2925-2929 CD denotes CD40
T1981 2930-2933 VBP denotes are
T1982 2934-2943 JJ denotes essential
T1983 2944-2947 IN denotes for
T1984 2948-2960 JJ denotes EBV-mediated
T1985 2961-2962 NNP denotes B
T1986 2963-2967 NN denotes cell
T1987 2968-2982 NN denotes transformation
T1988 2983-2984 NN denotes [
T1989 2984-2985 CD denotes 9
T1990 2986-2988 CD denotes 11
T1991 2988-2989 NN denotes ]
T1992 2989-2990 . denotes .
T1993 2991-2996 IN denotes While
T1994 2997-3001 CD denotes CD40
T1995 3002-3011 NNS denotes interacts
T1996 3012-3016 IN denotes with
T1997 3017-3021 JJ denotes CD40
T1998 3022-3028 NN denotes ligand
T1999 3029-3038 VBN denotes expressed
T2000 3039-3041 IN denotes on
T2001 3042-3051 VBN denotes activated
T2002 3052-3053 NNP denotes T
T2003 3054-3059 NNS denotes cells
T2004 3060-3062 TO denotes to
T2005 3063-3069 VB denotes induce
T2006 3070-3071 NNP denotes B
T2007 3072-3076 NN denotes cell
T2008 3077-3087 NN denotes activation
T2009 3088-3091 CC denotes and
T2010 3092-3107 NN denotes differentiation
T2011 3107-3108 , denotes ,
T2012 3109-3113 NNP denotes LMP1
T2013 3114-3118 VBZ denotes acts
T2014 3119-3121 IN denotes as
T2015 3122-3123 DT denotes a
T2016 3124-3136 JJ denotes constitutive
T2017 3137-3143 NN denotes signal
T2018 3144-3151 IN denotes through
T2019 3152-3170 JJ denotes ligand-independent
T2020 3171-3186 NN denotes oligomerization
T2021 3186-3187 . denotes .
T2022 3188-3192 CD denotes LMP1
T2023 3193-3196 CC denotes and
T2024 3197-3201 CD denotes CD40
T2025 3202-3210 NN denotes interact
T2026 3211-3215 IN denotes with
T2027 3216-3219 DT denotes the
T2028 3220-3224 JJ denotes same
T2029 3225-3230 NN denotes tumor
T2030 3231-3239 NN denotes necrosis
T2031 3240-3246 NN denotes factor
T2032 3247-3255 NN denotes receptor
T2033 3256-3266 VBN denotes associated
T2034 3267-3274 NNS denotes factors
T2035 3275-3276 -LRB- denotes (
T2036 3276-3281 NNS denotes TRAFs
T2037 3281-3282 -RRB- denotes )
T2038 3283-3290 VBG denotes leading
T2039 3291-3293 TO denotes to
T2040 3294-3304 NN denotes activation
T2041 3305-3307 IN denotes of
T2042 3308-3312 NNP denotes NFκB
T2043 3312-3313 , denotes ,
T2044 3314-3319 NNP denotes c-Jun
T2045 3320-3321 NNP denotes N
T2046 3322-3330 NN denotes terminal
T2047 3331-3337 NN denotes kinase
T2048 3338-3339 -LRB- denotes (
T2049 3339-3342 NNP denotes JNK
T2050 3342-3343 -RRB- denotes )
T2051 3343-3344 , denotes ,
T2052 3345-3348 CC denotes and
T2053 3349-3352 CD denotes p38
T2054 3353-3357 NNP denotes MAPK
T2055 3358-3367 VBG denotes signaling
T2056 3368-3376 NNS denotes pathways
T2057 3377-3378 NNP denotes [
T2058 3378-3380 CD denotes 12
T2059 3381-3383 CD denotes 16
T2060 3383-3384 NN denotes ]
T2061 3384-3385 . denotes .
T2062 3386-3396 NNP denotes Activation
T2063 3397-3399 IN denotes of
T2064 3400-3404 NNP denotes NFκB
T2065 3405-3407 VBZ denotes is
T2066 3408-3416 VBN denotes required
T2067 3417-3420 IN denotes for
T2068 3421-3432 JJ denotes EBV-induced
T2069 3433-3434 NNP denotes B
T2070 3435-3439 NN denotes cell
T2071 3440-3454 NN denotes transformation
T2072 3455-3458 CC denotes and
T2073 3459-3462 PRP$ denotes its
T2074 3463-3473 NN denotes inhibition
T2075 3474-3481 RB denotes rapidly
T2076 3482-3489 NNS denotes results
T2077 3490-3492 IN denotes in
T2078 3493-3497 NN denotes cell
T2079 3498-3503 NN denotes death
T2080 3504-3505 NNP denotes [
T2081 3505-3510 CD denotes 17,18
T2082 3510-3511 NNP denotes ]
T2083 3511-3512 . denotes .
T2084 3513-3519 JJ denotes Recent
T2085 3520-3527 NNS denotes studies
T2086 3528-3536 VBP denotes indicate
T2087 3537-3541 IN denotes that
T2088 3542-3546 NNP denotes LMP1
T2089 3547-3551 RB denotes also
T2090 3552-3561 VBZ denotes activates
T2091 3562-3582 NN denotes phosphatidylinositol
T2092 3583-3584 CD denotes 3
T2093 3585-3591 NN denotes kinase
T2094 3592-3593 -LRB- denotes (
T2095 3593-3597 NNP denotes PI3K
T2096 3597-3598 -RRB- denotes )
T2097 3598-3599 VBP denotes /
T2098 3599-3602 NNP denotes Akt
T2099 3603-3612 VBG denotes signaling
T2100 3613-3616 CC denotes and
T2101 3617-3621 IN denotes that
T2102 3622-3626 DT denotes this
T2103 3627-3637 NN denotes activation
T2104 3638-3640 VBZ denotes is
T2105 3641-3649 VBN denotes required
T2106 3650-3653 IN denotes for
T2107 3654-3667 JJ denotes LMP1-mediated
T2108 3668-3682 NN denotes transformation
T2109 3683-3685 IN denotes of
T2110 3686-3692 NN denotes rodent
T2111 3693-3704 NNS denotes fibroblasts
T2112 3705-3706 NNP denotes [
T2113 3706-3710 CD denotes 5,19
T2114 3710-3711 NNP denotes ]
T2115 3711-3712 . denotes .
T2116 3713-3715 IN denotes In
T2117 3716-3721 NN denotes vitro
T2118 3721-3722 , denotes ,
T2119 3723-3730 JJ denotes primary
T2120 3731-3732 NNP denotes B
T2121 3733-3738 NNS denotes cells
T2122 3739-3742 MD denotes can
T2123 3743-3745 VB denotes be
T2124 3746-3756 VBN denotes maintained
T2125 3757-3759 IN denotes by
T2126 3760-3764 NNP denotes CD40
T2127 3765-3773 NN denotes ligation
T2128 3774-3776 IN denotes in
T2129 3777-3788 NN denotes combination
T2130 3789-3793 IN denotes with
T2131 3794-3797 CD denotes IL4
T2132 3798-3807 NN denotes treatment
T2133 3807-3808 . denotes .
T2134 3809-3811 IN denotes In
T2135 3812-3816 NN denotes vivo
T2136 3816-3817 , denotes ,
T2137 3818-3822 NNP denotes CD40
T2138 3823-3832 VBG denotes signaling
T2139 3833-3835 VBZ denotes is
T2140 3836-3845 JJ denotes necessary
T2141 3846-3849 IN denotes for
T2142 3850-3858 JJ denotes germinal
T2143 3859-3865 NN denotes center
T2144 3866-3867 -LRB- denotes (
T2145 3867-3869 NNP denotes GC
T2146 3869-3870 -RRB- denotes )
T2147 3871-3880 NN denotes formation
T2148 3881-3885 JJ denotes such
T2149 3886-3890 IN denotes that
T2150 3891-3895 NNS denotes mice
T2151 3896-3905 NN denotes deficient
T2152 3906-3909 IN denotes for
T2153 3910-3914 NNP denotes CD40
T2154 3915-3917 CC denotes or
T2155 3918-3923 NNP denotes CD40L
T2156 3924-3927 VBP denotes are
T2157 3928-3934 JJ denotes unable
T2158 3935-3937 TO denotes to
T2159 3938-3942 VB denotes form
T2160 3943-3946 NNS denotes GCs
T2161 3947-3949 IN denotes in
T2162 3950-3958 NN denotes response
T2163 3959-3961 TO denotes to
T2164 3962-3963 NNP denotes T
T2165 3964-3968 NN denotes cell
T2166 3969-3978 JJ denotes dependent
T2167 3979-3987 NNS denotes antigens
T2168 3988-3989 NNP denotes [
T2169 3989-3994 CD denotes 20,21
T2170 3994-3995 NNP denotes ]
T2171 3995-3996 . denotes .
T2172 3997-4001 DT denotes Both
T2173 4002-4005 DT denotes the
T2174 4006-4014 NN denotes membrane
T2175 4015-4023 NN denotes proximal
T2176 4024-4027 CC denotes and
T2177 4028-4034 JJ denotes distal
T2178 4035-4046 JJ denotes cytoplasmic
T2179 4047-4054 NNS denotes regions
T2180 4055-4057 IN denotes of
T2181 4058-4062 NNP denotes CD40
T2182 4063-4067 IN denotes that
T2183 4068-4072 NN denotes bind
T2184 4073-4078 CD denotes TRAF6
T2185 4079-4082 CC denotes and
T2186 4083-4093 CD denotes TRAFs2/3/5
T2187 4093-4094 , denotes ,
T2188 4095-4107 RB denotes respectively
T2189 4107-4108 , denotes ,
T2190 4109-4112 VBP denotes are
T2191 4113-4122 JJ denotes necessary
T2192 4123-4126 IN denotes for
T2193 4127-4129 NNP denotes GC
T2194 4130-4139 NN denotes formation
T2195 4139-4140 , denotes ,
T2196 4141-4144 CC denotes but
T2197 4145-4151 DT denotes either
T2198 4152-4158 NN denotes region
T2199 4159-4161 VBZ denotes is
T2200 4162-4172 JJ denotes sufficient
T2201 4173-4175 TO denotes to
T2202 4176-4182 VB denotes induce
T2203 4183-4198 JJ denotes extrafollicular
T2204 4199-4200 NNP denotes B
T2205 4201-4205 NN denotes cell
T2206 4206-4221 NN denotes differentiation
T2207 4222-4225 CC denotes and
T2208 4226-4233 VB denotes restore
T2209 4234-4237 JJ denotes low
T2210 4238-4246 NN denotes affinity
T2211 4247-4255 NN denotes antibody
T2212 4256-4266 NN denotes production
T2213 4267-4268 NNP denotes [
T2214 4268-4270 CD denotes 22
T2215 4270-4271 NNP denotes ]
T2216 4271-4272 . denotes .
T2217 4273-4285 RB denotes Functionally
T2218 4285-4286 , denotes ,
T2219 4287-4291 NNP denotes LMP1
T2220 4292-4295 MD denotes can
T2221 4296-4302 VB denotes rescue
T2222 4303-4317 JJ denotes CD40-deficient
T2223 4318-4322 NNS denotes mice
T2224 4323-4326 CC denotes and
T2225 4327-4334 VB denotes restore
T2226 4335-4349 NN denotes immunoglobulin
T2227 4350-4351 -LRB- denotes (
T2228 4351-4353 NNP denotes Ig
T2229 4353-4354 -RRB- denotes )
T2230 4355-4360 NN denotes class
T2231 4361-4370 NN denotes switching
T2232 4370-4371 , denotes ,
T2233 4372-4376 RBS denotes most
T2234 4377-4383 JJ denotes likely
T2235 4384-4391 IN denotes because
T2236 4392-4396 CD denotes LMP1
T2237 4397-4405 NNS denotes recruits
T2238 4406-4413 JJ denotes similar
T2239 4414-4418 NNP denotes TRAF
T2240 4419-4428 NNS denotes molecules
T2241 4428-4429 , denotes ,
T2242 4430-4435 VBZ denotes TRAFs
T2243 4436-4441 CD denotes 1/2/3
T2244 4441-4442 NN denotes /
T2245 4442-4443 CD denotes 5
T2246 4444-4447 CC denotes and
T2247 4448-4453 CD denotes TRAF6
T2248 4453-4454 , denotes ,
T2249 4455-4462 IN denotes through
T2250 4463-4466 DT denotes the
T2251 4467-4477 JJ denotes C-terminal
T2252 4478-4488 NN denotes activation
T2253 4489-4496 NNS denotes regions
T2254 4497-4498 CD denotes 1
T2255 4499-4502 CC denotes and
T2256 4503-4504 CD denotes 2
T2257 4505-4512 NNS denotes domains
T2258 4512-4513 , denotes ,
T2259 4514-4526 RB denotes respectively
T2260 4526-4527 . denotes .
T2261 4528-4535 RB denotes However
T2262 4535-4536 , denotes ,
T2263 4537-4541 NNP denotes LMP1
T2264 4542-4544 VBZ denotes is
T2265 4545-4551 JJ denotes unable
T2266 4552-4554 TO denotes to
T2267 4555-4562 VB denotes restore
T2268 4563-4571 NN denotes affinity
T2269 4572-4582 NN denotes maturation
T2270 4583-4586 CC denotes and
T2271 4587-4589 NNP denotes GC
T2272 4590-4599 NN denotes formation
T2273 4600-4601 NNP denotes [
T2274 4601-4603 CD denotes 23
T2275 4603-4604 NNP denotes ]
T2276 4604-4605 . denotes .
T2277 4606-4613 JJ denotes Several
T2278 4614-4617 NNP denotes EBV
T2279 4618-4630 VBG denotes transforming
T2280 4631-4639 NNS denotes proteins
T2281 4640-4644 VBP denotes have
T2282 4645-4649 VBN denotes been
T2283 4650-4657 VBN denotes studied
T2284 4658-4660 IN denotes in
T2285 4661-4671 JJ denotes transgenic
T2286 4672-4677 NN denotes mouse
T2287 4678-4684 NNS denotes models
T2288 4684-4685 , denotes ,
T2289 4686-4693 RB denotes however
T2290 4693-4694 , denotes ,
T2291 4695-4699 RB denotes only
T2292 4700-4704 CD denotes LMP1
T2293 4705-4712 VBZ denotes induces
T2294 4713-4718 NN denotes tumor
T2295 4719-4730 NN denotes development
T2296 4731-4735 WRB denotes when
T2297 4736-4745 VBN denotes expressed
T2298 4746-4751 IN denotes under
T2299 4752-4755 DT denotes the
T2300 4756-4763 NN denotes control
T2301 4764-4766 IN denotes of
T2302 4767-4770 DT denotes the
T2303 4771-4773 NNP denotes Ig
T2304 4774-4779 JJ denotes heavy
T2305 4780-4785 NN denotes chain
T2306 4786-4794 NN denotes promoter
T2307 4795-4798 CC denotes and
T2308 4799-4807 NN denotes enhancer
T2309 4808-4809 NNP denotes [
T2310 4809-4811 CD denotes 24
T2311 4812-4814 CD denotes 26
T2312 4814-4815 NN denotes ]
T2313 4815-4816 . denotes .
T2314 4817-4820 DT denotes The
T2315 4821-4825 NNP denotes LMP1
T2316 4826-4836 NN denotes transgenic
T2317 4837-4841 NNS denotes mice
T2318 4842-4843 -LRB- denotes (
T2319 4843-4849 NNP denotes IgLMP1
T2320 4849-4850 -RRB- denotes )
T2321 4851-4858 VBP denotes express
T2322 4859-4863 CD denotes LMP1
T2323 4864-4866 IN denotes in
T2324 4867-4868 NNP denotes B
T2325 4869-4880 NNS denotes lymphocytes
T2326 4880-4881 , denotes ,
T2327 4882-4885 CC denotes and
T2328 4886-4888 IN denotes in
T2329 4889-4893 NNS denotes mice
T2330 4894-4899 JJR denotes older
T2331 4900-4904 IN denotes than
T2332 4905-4907 CD denotes 12
T2333 4908-4910 NN denotes mo
T2334 4910-4911 , denotes ,
T2335 4912-4920 NN denotes lymphoma
T2336 4921-4929 VBZ denotes develops
T2337 4930-4934 IN denotes with
T2338 4935-4944 VBN denotes increased
T2339 4945-4954 NN denotes incidence
T2340 4955-4956 -LRB- denotes (
T2341 4956-4958 CD denotes 40
T2342 4958-4959 NN denotes %
T2343 4960-4962 CD denotes 50
T2344 4962-4963 NN denotes %
T2345 4963-4964 -RRB- denotes )
T2346 4965-4973 VBN denotes compared
T2347 4974-4976 TO denotes to
T2348 4977-4986 JJ denotes wild-type
T2349 4987-4994 NN denotes control
T2350 4995-4999 NNS denotes mice
T2351 5000-5001 -LRB- denotes (
T2352 5001-5003 CD denotes 11
T2353 5003-5004 NN denotes %
T2354 5004-5005 -RRB- denotes )
T2355 5005-5006 , denotes ,
T2356 5007-5017 VBG denotes suggesting
T2357 5018-5022 IN denotes that
T2358 5023-5027 CD denotes LMP1
T2359 5028-5039 VBZ denotes contributes
T2360 5040-5042 TO denotes to
T2361 5043-5048 NN denotes tumor
T2362 5049-5060 NN denotes development
T2363 5061-5062 NNP denotes [
T2364 5062-5064 CD denotes 26
T2365 5064-5065 NNP denotes ]
T2366 5065-5066 . denotes .
T2367 5067-5070 DT denotes The
T2368 5071-5075 NNP denotes LMP1
T2369 5076-5085 NNS denotes lymphomas
T2370 5086-5090 VBP denotes have
T2371 5091-5101 VBN denotes rearranged
T2372 5102-5104 NNP denotes Ig
T2373 5105-5110 NNS denotes genes
T2374 5111-5114 CC denotes and
T2375 5115-5119 VBP denotes have
T2376 5120-5129 VBN denotes activated
T2377 5130-5133 NNP denotes Akt
T2378 5133-5134 , denotes ,
T2379 5135-5138 NNP denotes JNK
T2380 5138-5139 , denotes ,
T2381 5140-5143 CD denotes p38
T2382 5143-5144 , denotes ,
T2383 5145-5148 CC denotes and
T2384 5149-5153 NNP denotes NFκB
T2385 5153-5154 , denotes ,
T2386 5155-5159 IN denotes with
T2387 5160-5168 JJ denotes specific
T2388 5169-5179 NN denotes activation
T2389 5180-5182 IN denotes of
T2390 5183-5186 DT denotes the
T2391 5187-5191 NNP denotes NFκB
T2392 5192-5198 NN denotes family
T2393 5199-5205 NN denotes member
T2394 5206-5210 NNP denotes cRel
T2395 5211-5212 NNP denotes [
T2396 5212-5214 CD denotes 27
T2397 5214-5215 NNP denotes ]
T2398 5215-5216 . denotes .
T2399 5217-5219 IN denotes In
T2400 5220-5224 DT denotes this
T2401 5225-5230 NN denotes study
T2402 5230-5231 , denotes ,
T2403 5232-5235 DT denotes the
T2404 5236-5240 NNP denotes LMP1
T2405 5241-5251 NN denotes transgenic
T2406 5252-5263 NNS denotes lymphocytes
T2407 5264-5267 CC denotes and
T2408 5268-5277 NNS denotes lymphomas
T2409 5278-5282 VBD denotes were
T2410 5283-5290 JJ denotes further
T2411 5291-5304 VBN denotes characterized
T2412 5305-5308 CC denotes and
T2413 5309-5314 PRP$ denotes their
T2414 5315-5321 NN denotes growth
T2415 5322-5332 NNS denotes properties
T2416 5333-5335 IN denotes in
T2417 5336-5341 NN denotes vitro
T2418 5342-5346 VBD denotes were
T2419 5347-5357 VBN denotes determined
T2420 5357-5358 . denotes .
T2421 5359-5361 TO denotes To
T2422 5362-5368 VB denotes obtain
T2423 5369-5373 JJ denotes pure
T2424 5374-5385 NNS denotes populations
T2425 5386-5388 IN denotes of
T2426 5389-5398 JJ denotes malignant
T2427 5399-5410 NNS denotes lymphocytes
T2428 5411-5414 CC denotes and
T2429 5415-5417 TO denotes to
T2430 5418-5424 VB denotes enable
T2431 5425-5429 JJR denotes more
T2432 5430-5438 JJ denotes detailed
T2433 5439-5450 NN denotes biochemical
T2434 5451-5459 NNS denotes analyses
T2435 5459-5460 , denotes ,
T2436 5461-5469 NNS denotes examples
T2437 5470-5472 IN denotes of
T2438 5473-5480 JJ denotes primary
T2439 5481-5490 NNS denotes lymphomas
T2440 5491-5495 VBD denotes were
T2441 5496-5506 VBN denotes inoculated
T2442 5507-5510 CC denotes and
T2443 5511-5519 VBN denotes passaged
T2444 5520-5522 IN denotes in
T2445 5523-5527 NNP denotes SCID
T2446 5528-5532 NNS denotes mice
T2447 5532-5533 . denotes .
T2448 5534-5547 RB denotes Interestingly
T2449 5547-5548 , denotes ,
T2450 5549-5557 NN denotes lymphoma
T2451 5558-5569 NN denotes development
T2452 5570-5573 VBD denotes was
T2453 5574-5584 VBN denotes restricted
T2454 5585-5587 TO denotes to
T2455 5588-5592 JJ denotes B-1a
T2456 5593-5604 NNS denotes lymphocytes
T2457 5604-5605 , denotes ,
T2458 5606-5607 DT denotes a
T2459 5608-5625 JJ denotes self-replenishing
T2460 5626-5636 NN denotes population
T2461 5637-5639 IN denotes of
T2462 5640-5645 NNS denotes cells
T2463 5646-5650 WDT denotes that
T2464 5651-5654 VBP denotes are
T2465 5655-5660 JJ denotes prone
T2466 5661-5663 TO denotes to
T2467 5664-5674 NN denotes malignancy
T2468 5675-5676 NNP denotes [
T2469 5676-5681 CD denotes 28,29
T2470 5681-5682 NNP denotes ]
T2471 5682-5683 . denotes .
T2472 5684-5688 CD denotes LMP1
T2473 5689-5699 JJ denotes transgenic
T2474 5700-5711 NNS denotes lymphocytes
T2475 5712-5715 VBD denotes had
T2476 5716-5725 VBN denotes increased
T2477 5726-5735 NN denotes viability
T2478 5736-5738 IN denotes in
T2479 5739-5744 NN denotes vitro
T2480 5745-5748 CC denotes and
T2481 5749-5758 NN denotes viability
T2482 5759-5762 VBD denotes was
T2483 5763-5772 VBN denotes increased
T2484 5773-5775 IN denotes by
T2485 5776-5779 DT denotes the
T2486 5780-5788 NN denotes addition
T2487 5789-5791 IN denotes of
T2488 5792-5795 NNP denotes IL4
T2489 5795-5796 . denotes .
T2490 5797-5799 IN denotes In
T2491 5800-5808 NN denotes contrast
T2492 5808-5809 , denotes ,
T2493 5810-5814 DT denotes both
T2494 5815-5828 JJ denotes LMP1-positive
T2495 5829-5832 CC denotes and
T2496 5833-5834 : denotes -
T2497 5834-5842 JJ denotes negative
T2498 5843-5851 NN denotes lymphoma
T2499 5852-5857 NNS denotes cells
T2500 5858-5862 VBD denotes were
T2501 5863-5874 JJ denotes independent
T2502 5875-5877 IN denotes of
T2503 5878-5881 CD denotes IL4
T2504 5882-5896 NN denotes co-stimulation
T2505 5897-5900 IN denotes for
T2506 5901-5909 NN denotes survival
T2507 5910-5913 CC denotes and
T2508 5914-5927 NN denotes proliferation
T2509 5928-5930 IN denotes in
T2510 5931-5936 NN denotes vitro
T2511 5937-5941 IN denotes with
T2512 5942-5943 DT denotes a
T2513 5944-5952 JJ denotes complete
T2514 5953-5960 NN denotes absence
T2515 5961-5963 IN denotes of
T2516 5964-5973 VBN denotes activated
T2517 5974-5979 NNP denotes Stat6
T2518 5979-5980 , denotes ,
T2519 5981-5984 DT denotes the
T2520 5985-5988 NNP denotes IL4
T2521 5989-5995 NN denotes target
T2522 5995-5996 . denotes .
T2523 5997-6000 DT denotes The
T2524 6001-6010 NNS denotes lymphomas
T2525 6011-6015 VBD denotes were
T2526 6016-6020 RB denotes also
T2527 6021-6034 VBN denotes distinguished
T2528 6035-6037 IN denotes by
T2529 6038-6050 JJ denotes constitutive
T2530 6051-6061 NN denotes activation
T2531 6062-6064 IN denotes of
T2532 6065-6070 NNP denotes Stat3
T2533 6071-6074 CC denotes and
T2534 6075-6087 NN denotes deregulation
T2535 6088-6090 IN denotes of
T2536 6091-6094 DT denotes the
T2537 6095-6097 NNP denotes Rb
T2538 6098-6102 NN denotes cell
T2539 6103-6108 NN denotes cycle
T2540 6109-6116 NN denotes pathway
T2541 6116-6117 . denotes .
T2542 6118-6128 NNP denotes Inhibition
T2543 6129-6131 IN denotes of
T2544 6132-6135 DT denotes the
T2545 6136-6144 NNP denotes PI3K/Akt
T2546 6144-6145 , denotes ,
T2547 6146-6150 NNP denotes NFκB
T2548 6150-6151 , denotes ,
T2549 6152-6155 CC denotes and
T2550 6156-6161 JJ denotes Stat3
T2551 6162-6171 VBG denotes signaling
T2552 6172-6180 NNS denotes pathways
T2553 6181-6188 VBD denotes blocked
T2554 6189-6192 DT denotes the
T2555 6193-6201 JJ denotes enhanced
T2556 6202-6208 NN denotes growth
T2557 6209-6211 IN denotes of
T2558 6212-6216 DT denotes both
T2559 6217-6221 CD denotes LMP1
T2560 6222-6232 NN denotes transgenic
T2561 6233-6236 CC denotes and
T2562 6237-6246 JJ denotes malignant
T2563 6247-6258 NNS denotes lymphocytes
T2564 6258-6259 , denotes ,
T2565 6260-6270 VBG denotes suggesting
T2566 6271-6275 IN denotes that
T2567 6276-6281 DT denotes these
T2568 6282-6290 NNS denotes pathways
T2569 6291-6294 VBP denotes are
T2570 6295-6303 VBN denotes required
T2571 6304-6307 IN denotes for
T2572 6308-6313 PRP$ denotes their
T2573 6314-6320 NN denotes growth
T2574 6321-6324 CC denotes and
T2575 6325-6333 NN denotes survival
T2576 6333-6334 . denotes .
T2577 6335-6340 DT denotes These
T2578 6341-6347 VBP denotes appear
T2579 6348-6350 TO denotes to
T2580 6351-6353 VB denotes be
T2581 6354-6357 DT denotes the
T2582 6358-6362 JJ denotes same
T2583 6363-6370 NNS denotes targets
T2584 6371-6375 WDT denotes that
T2585 6376-6379 VBP denotes are
T2586 6380-6391 VBN denotes deregulated
T2587 6392-6394 IN denotes in
T2588 6395-6404 JJ denotes wild-type
T2589 6405-6409 NN denotes B-1a
T2590 6410-6419 NNS denotes lymphomas
T2591 6420-6424 WDT denotes that
T2592 6425-6430 VBP denotes arise
T2593 6431-6444 RB denotes spontaneously
T2594 6445-6452 IN denotes through
T2595 6453-6456 NN denotes age
T2596 6457-6471 NN denotes predisposition
T2597 6471-6472 . denotes .
T2598 6473-6477 DT denotes This
T2599 6478-6483 NN denotes study
T2600 6484-6491 VBZ denotes reveals
T2601 6492-6496 IN denotes that
T2602 6497-6501 CD denotes LMP1
T2603 6502-6510 VBZ denotes promotes
T2604 6511-6521 NN denotes malignancy
T2605 6522-6524 IN denotes in
T2606 6525-6530 NNS denotes cells
T2607 6531-6535 IN denotes with
T2608 6536-6539 DT denotes the
T2609 6540-6548 JJ denotes inherent
T2610 6549-6556 NN denotes ability
T2611 6557-6559 TO denotes to
T2612 6560-6571 VB denotes proliferate
T2613 6572-6575 CC denotes and
T2614 6576-6580 IN denotes that
T2615 6581-6584 DT denotes the
T2616 6585-6588 NNP denotes Akt
T2617 6588-6589 , denotes ,
T2618 6590-6594 NNP denotes NFκB
T2619 6594-6595 , denotes ,
T2620 6596-6599 CC denotes and
T2621 6600-6605 JJ denotes Stat3
T2622 6606-6615 VBG denotes signaling
T2623 6616-6624 NNS denotes pathways
T2624 6625-6628 VBP denotes are
T2625 6629-6637 VBN denotes required
T2626 6638-6641 IN denotes for
T2627 6642-6645 PRP$ denotes its
T2628 6646-6652 NN denotes growth
T2629 6653-6664 JJ denotes stimulatory
T2630 6665-6672 NNS denotes effects
T2631 6672-6673 . denotes .
T3518 6684-6688 NNP denotes High
T3519 6689-6695 NNP denotes Levels
T3520 6696-6698 IN denotes of
T3521 6699-6703 NNP denotes LMP1
T3522 6704-6714 NNP denotes Expression
T3523 6715-6725 NNPS denotes Correlates
T3524 6726-6730 IN denotes with
T3525 6731-6734 DT denotes the
T3526 6735-6746 NNP denotes Development
T3527 6747-6749 IN denotes of
T3528 6750-6758 NNP denotes Lymphoma
T3529 6759-6763 NNP denotes LMP1
T3530 6764-6774 NN denotes expression
T3531 6775-6777 IN denotes in
T3532 6778-6784 NNP denotes IgLMP1
T3533 6785-6789 NNS denotes mice
T3534 6790-6793 VBD denotes was
T3535 6794-6802 VBN denotes directed
T3536 6803-6805 TO denotes to
T3537 6806-6807 NNP denotes B
T3538 6808-6813 NNS denotes cells
T3539 6814-6819 IN denotes under
T3540 6820-6823 DT denotes the
T3541 6824-6831 NN denotes control
T3542 6832-6834 IN denotes of
T3543 6835-6838 DT denotes the
T3544 6839-6841 NNP denotes Ig
T3545 6842-6847 JJ denotes heavy
T3546 6848-6853 NN denotes chain
T3547 6854-6862 NN denotes promoter
T3548 6863-6866 CC denotes and
T3549 6867-6875 NN denotes enhancer
T3550 6875-6876 . denotes .
T3551 6877-6879 PRP denotes It
T3552 6880-6883 VBZ denotes has
T3553 6884-6894 RB denotes previously
T3554 6895-6899 VBN denotes been
T3555 6900-6905 VBN denotes shown
T3556 6906-6910 IN denotes that
T3557 6911-6913 IN denotes in
T3558 6914-6919 DT denotes these
T3559 6920-6930 JJ denotes transgenic
T3560 6931-6935 NNS denotes mice
T3561 6935-6936 , denotes ,
T3562 6937-6941 NNP denotes LMP1
T3563 6942-6952 NN denotes expression
T3564 6953-6956 VBD denotes was
T3565 6957-6967 VBN denotes restricted
T3566 6968-6970 TO denotes to
T3567 6971-6975 NNP denotes B220
T3568 6975-6976 NNP denotes +
T3569 6977-6978 NNP denotes B
T3570 6979-6984 NNS denotes cells
T3571 6985-6989 IN denotes with
T3572 6990-6998 NN denotes lymphoma
T3573 6999-7007 VBN denotes detected
T3574 7008-7010 IN denotes in
T3575 7011-7018 RB denotes greatly
T3576 7019-7027 JJ denotes enlarged
T3577 7028-7035 NNS denotes spleens
T3578 7036-7037 NNP denotes [
T3579 7037-7042 CD denotes 23,26
T3580 7042-7043 NNP denotes ]
T3581 7043-7044 . denotes .
T3582 7045-7047 TO denotes To
T3583 7048-7059 VB denotes investigate
T3584 7060-7067 IN denotes whether
T3585 7068-7072 NNP denotes LMP1
T3586 7073-7083 NN denotes expression
T3587 7084-7095 VBZ denotes contributes
T3588 7096-7098 TO denotes to
T3589 7099-7107 VB denotes lymphoma
T3590 7108-7119 NN denotes development
T3591 7119-7120 , denotes ,
T3592 7121-7122 NNP denotes B
T3593 7123-7128 NNS denotes cells
T3594 7129-7133 VBD denotes were
T3595 7134-7142 VBN denotes purified
T3596 7143-7147 IN denotes from
T3597 7148-7159 NNS denotes splenocytes
T3598 7160-7162 IN denotes by
T3599 7163-7171 JJ denotes positive
T3600 7172-7181 NN denotes selection
T3601 7182-7187 VBG denotes using
T3602 7188-7197 JJ denotes anti-CD19
T3603 7198-7202 NNP denotes MACS
T3604 7203-7211 JJ denotes magnetic
T3605 7212-7217 NNS denotes beads
T3606 7217-7218 , denotes ,
T3607 7219-7222 CC denotes and
T3608 7223-7233 JJ denotes equivalent
T3609 7234-7241 NNS denotes amounts
T3610 7242-7244 IN denotes of
T3611 7245-7246 NNP denotes B
T3612 7247-7252 NNS denotes cells
T3613 7253-7257 VBD denotes were
T3614 7258-7266 VBN denotes analyzed
T3615 7267-7269 IN denotes by
T3616 7270-7284 VBG denotes immunoblotting
T3617 7284-7285 . denotes .
T3618 7286-7290 CD denotes LMP1
T3619 7291-7294 VBD denotes was
T3620 7295-7305 JJ denotes detectable
T3621 7306-7308 IN denotes in
T3622 7309-7313 CD denotes LMP1
T3623 7314-7324 JJ denotes transgenic
T3624 7325-7326 NNP denotes B
T3625 7327-7332 NNS denotes cells
T3626 7332-7333 , denotes ,
T3627 7334-7337 CC denotes but
T3628 7338-7342 IN denotes upon
T3629 7343-7354 NN denotes development
T3630 7355-7357 IN denotes of
T3631 7358-7366 NN denotes lymphoma
T3632 7366-7367 , denotes ,
T3633 7368-7372 NNP denotes LMP1
T3634 7373-7383 NN denotes expression
T3635 7384-7387 VBD denotes was
T3636 7388-7396 JJR denotes stronger
T3637 7397-7399 IN denotes in
T3638 7400-7403 CD denotes 5/7
T3639 7404-7413 NNS denotes lymphomas
T3640 7414-7422 VBD denotes analyzed
T3641 7423-7427 IN denotes with
T3642 7428-7439 JJ denotes concomitant
T3643 7440-7450 NN denotes appearance
T3644 7451-7453 IN denotes of
T3645 7454-7465 NN denotes degradation
T3646 7466-7474 NNS denotes products
T3647 7475-7476 -LRB- denotes (
T3648 7476-7482 NN denotes Figure
T3649 7483-7485 CD denotes 1A
T3650 7485-7486 -RRB- denotes )
T3651 7486-7487 . denotes .
T3652 7488-7490 TO denotes To
T3653 7491-7500 VB denotes determine
T3654 7501-7508 IN denotes whether
T3655 7509-7512 DT denotes the
T3656 7513-7519 JJR denotes higher
T3657 7520-7525 NN denotes level
T3658 7526-7528 IN denotes of
T3659 7529-7533 NNP denotes LMP1
T3660 7534-7542 VBD denotes detected
T3661 7543-7546 VBD denotes was
T3662 7547-7550 JJ denotes due
T3663 7551-7553 TO denotes to
T3664 7554-7556 DT denotes an
T3665 7557-7566 NN denotes expansion
T3666 7567-7569 IN denotes of
T3667 7570-7579 JJ denotes malignant
T3668 7580-7591 NNS denotes lymphocytes
T3669 7591-7592 , denotes ,
T3670 7593-7603 NN denotes expression
T3671 7604-7606 IN denotes of
T3672 7607-7611 CD denotes LMP1
T3673 7612-7614 IN denotes in
T3674 7615-7618 DT denotes the
T3675 7619-7625 NN denotes spleen
T3676 7626-7629 VBD denotes was
T3677 7630-7637 JJ denotes further
T3678 7638-7647 VBN denotes evaluated
T3679 7648-7650 IN denotes by
T3680 7651-7670 JJ denotes immunohistochemical
T3681 7671-7679 NN denotes staining
T3682 7679-7680 . denotes .
T3683 7681-7701 NNP denotes Immunohistochemistry
T3684 7702-7710 NN denotes analysis
T3685 7711-7713 IN denotes of
T3686 7714-7720 JJ denotes spleen
T3687 7721-7729 NNS denotes sections
T3688 7730-7738 VBD denotes detected
T3689 7739-7743 CD denotes LMP1
T3690 7744-7746 IN denotes in
T3691 7747-7750 DT denotes the
T3692 7751-7757 NN denotes plasma
T3693 7758-7766 NN denotes membrane
T3694 7767-7769 IN denotes of
T3695 7770-7775 NNS denotes cells
T3696 7776-7778 IN denotes in
T3697 7779-7783 DT denotes both
T3698 7784-7787 DT denotes the
T3699 7788-7798 JJ denotes follicular
T3700 7799-7804 JJ denotes white
T3701 7805-7809 NN denotes pulp
T3702 7810-7813 CC denotes and
T3703 7814-7825 VBG denotes circulating
T3704 7826-7837 NNS denotes lymphocytes
T3705 7838-7840 IN denotes in
T3706 7841-7844 DT denotes the
T3707 7845-7848 JJ denotes red
T3708 7849-7853 NN denotes pulp
T3709 7854-7855 -LRB- denotes (
T3710 7855-7861 NN denotes Figure
T3711 7862-7864 NN denotes 1B
T3712 7864-7865 -RRB- denotes )
T3713 7865-7866 . denotes .
T3714 7867-7871 CD denotes LMP1
T3715 7872-7882 NN denotes expression
T3716 7883-7886 VBD denotes was
T3717 7887-7900 JJ denotes heterogeneous
T3718 7901-7905 IN denotes with
T3719 7906-7912 JJ denotes strong
T3720 7913-7917 NNP denotes LMP1
T3721 7918-7926 VBG denotes staining
T3722 7927-7939 VBN denotes interspersed
T3723 7940-7947 IN denotes amongst
T3724 7948-7949 DT denotes a
T3725 7950-7960 NN denotes background
T3726 7961-7963 IN denotes of
T3727 7964-7969 NNS denotes cells
T3728 7970-7978 VBG denotes staining
T3729 7979-7985 RB denotes weakly
T3730 7986-7989 IN denotes for
T3731 7990-7994 NNP denotes LMP1
T3732 7994-7995 . denotes .
T3733 7996-8000 IN denotes Upon
T3734 8001-8012 NN denotes development
T3735 8013-8015 TO denotes to
T3736 8016-8024 NN denotes lymphoma
T3737 8024-8025 , denotes ,
T3738 8026-8030 NNP denotes LMP1
T3739 8031-8041 NN denotes expression
T3740 8042-8045 VBD denotes was
T3741 8046-8050 RBR denotes more
T3742 8051-8061 RB denotes abundantly
T3743 8062-8070 VBN denotes detected
T3744 8071-8075 IN denotes with
T3745 8076-8084 JJ denotes multiple
T3746 8085-8089 NNS denotes foci
T3747 8090-8092 IN denotes of
T3748 8093-8100 JJ denotes intense
T3749 8101-8105 NNP denotes LMP1
T3750 8106-8114 NN denotes staining
T3751 8114-8115 . denotes .
T3752 8116-8120 DT denotes This
T3753 8121-8133 VBZ denotes demonstrates
T3754 8134-8138 IN denotes that
T3755 8139-8142 DT denotes the
T3756 8143-8152 VBN denotes increased
T3757 8153-8157 NNP denotes LMP1
T3758 8158-8166 VBN denotes detected
T3759 8167-8169 IN denotes by
T3760 8170-8184 VBG denotes immunoblotting
T3761 8185-8189 IN denotes upon
T3762 8190-8199 JJ denotes malignant
T3763 8200-8211 NN denotes progression
T3764 8212-8220 VBZ denotes reflects
T3765 8221-8223 DT denotes an
T3766 8224-8232 NN denotes increase
T3767 8233-8235 IN denotes in
T3768 8236-8240 CD denotes LMP1
T3769 8241-8251 NN denotes expression
T3770 8252-8255 CC denotes and
T3771 8256-8258 DT denotes an
T3772 8259-8271 NN denotes accumulation
T3773 8272-8274 IN denotes of
T3774 8275-8280 NNS denotes cells
T3775 8281-8291 VBG denotes expressing
T3776 8292-8296 JJ denotes high
T3777 8297-8303 NNS denotes levels
T3778 8304-8306 IN denotes of
T3779 8307-8311 NNP denotes LMP1
T3780 8311-8312 . denotes .
T3781 8313-8317 DT denotes This
T3782 8318-8329 NN denotes correlation
T3783 8330-8337 IN denotes between
T3784 8338-8342 JJ denotes high
T3785 8343-8347 CD denotes LMP1
T3786 8348-8358 NN denotes expression
T3787 8359-8362 CC denotes and
T3788 8363-8366 DT denotes the
T3789 8367-8378 NN denotes development
T3790 8379-8381 IN denotes of
T3791 8382-8390 NN denotes lymphoma
T3792 8391-8399 VBZ denotes suggests
T3793 8400-8404 IN denotes that
T3794 8405-8416 NN denotes progression
T3795 8417-8419 TO denotes to
T3796 8420-8428 NN denotes lymphoma
T3797 8429-8436 NNS denotes results
T3798 8437-8441 IN denotes from
T3799 8442-8451 VBN denotes increased
T3800 8452-8458 NNS denotes levels
T3801 8459-8461 IN denotes of
T3802 8462-8466 NNP denotes LMP1
T3803 8466-8467 . denotes .
T4681 9020-9024 CD denotes LMP1
T4682 9025-9033 NNP denotes Promotes
T4683 9034-9038 NNP denotes B-1a
T4684 9039-9048 NNP denotes Lymphomas
T4685 9049-9053 WDT denotes That
T4686 9054-9057 MD denotes Can
T4687 9058-9064 VB denotes Escape
T4688 9065-9072 NNP denotes Allelic
T4689 9073-9082 NNP denotes Exclusion
T4690 9083-9085 TO denotes To
T4691 9086-9095 VB denotes determine
T4692 9096-9098 IN denotes if
T4693 9099-9103 CD denotes LMP1
T4694 9104-9113 VBG denotes signaling
T4695 9114-9121 VBZ denotes affects
T4696 9122-9123 NNP denotes B
T4697 9124-9128 NN denotes cell
T4698 9129-9144 NN denotes differentiation
T4699 9145-9148 CC denotes and
T4700 9149-9151 TO denotes to
T4701 9152-9167 VB denotes immunophenotype
T4702 9168-9171 DT denotes the
T4703 9172-9181 NNS denotes lymphomas
T4704 9182-9186 WDT denotes that
T4705 9187-9192 VBP denotes arise
T4706 9193-9197 IN denotes from
T4707 9198-9202 CD denotes LMP1
T4708 9203-9213 NN denotes expression
T4709 9213-9214 , denotes ,
T4710 9215-9222 NN denotes surface
T4711 9223-9225 NNP denotes Ig
T4712 9226-9236 NN denotes expression
T4713 9237-9239 IN denotes of
T4714 9240-9245 JJ denotes heavy
T4715 9246-9252 NNS denotes chains
T4716 9253-9254 -LRB- denotes (
T4717 9254-9257 NNP denotes IgM
T4718 9257-9258 , denotes ,
T4719 9259-9262 NNP denotes IgG
T4720 9262-9263 , denotes ,
T4721 9264-9267 NNP denotes IgD
T4722 9267-9268 -RRB- denotes )
T4723 9269-9272 CC denotes and
T4724 9273-9278 JJ denotes light
T4725 9279-9285 NNS denotes chains
T4726 9286-9287 -LRB- denotes (
T4727 9287-9288 NN denotes κ
T4728 9288-9289 , denotes ,
T4729 9290-9291 NN denotes λ
T4730 9291-9292 -RRB- denotes )
T4731 9293-9297 VBD denotes were
T4732 9298-9306 VBN denotes analyzed
T4733 9307-9309 IN denotes by
T4734 9310-9314 NN denotes flow
T4735 9315-9324 NN denotes cytometry
T4736 9324-9325 . denotes .
T4737 9326-9333 JJ denotes Similar
T4738 9334-9341 NNS denotes numbers
T4739 9342-9344 IN denotes of
T4740 9345-9350 NN denotes naïve
T4741 9351-9352 -LRB- denotes (
T4742 9352-9355 NNP denotes IgM
T4743 9355-9356 NNP denotes +
T4744 9356-9359 NNP denotes IgD
T4745 9359-9360 NNP denotes +
T4746 9360-9363 NNP denotes IgG
T4747 9363-9364 NNP denotes −
T4748 9364-9365 -RRB- denotes )
T4749 9366-9373 JJ denotes splenic
T4750 9374-9375 NNP denotes B
T4751 9376-9381 NNS denotes cells
T4752 9382-9386 IN denotes with
T4753 9387-9388 DT denotes a
T4754 9389-9395 JJ denotes strong
T4755 9396-9400 NN denotes bias
T4756 9401-9408 IN denotes towards
T4757 9409-9410 NN denotes κ
T4758 9411-9416 NN denotes light
T4759 9417-9422 NN denotes chain
T4760 9423-9427 VBD denotes were
T4761 9428-9436 VBN denotes detected
T4762 9437-9441 IN denotes from
T4763 9442-9451 JJ denotes wild-type
T4764 9452-9454 CC denotes or
T4765 9455-9459 JJ denotes LMP1
T4766 9460-9470 JJ denotes transgenic
T4767 9471-9475 NNS denotes mice
T4768 9475-9476 , denotes ,
T4769 9477-9487 VBG denotes indicating
T4770 9488-9492 IN denotes that
T4771 9493-9497 CD denotes LMP1
T4772 9498-9507 VBG denotes signaling
T4773 9508-9512 VBZ denotes does
T4774 9513-9516 RB denotes not
T4775 9517-9523 VB denotes affect
T4776 9524-9525 NNP denotes B
T4777 9526-9530 NN denotes cell
T4778 9531-9541 NN denotes maturation
T4779 9542-9543 -LRB- denotes (
T4780 9543-9554 JJ denotes unpublished
T4781 9555-9559 NNS denotes data
T4782 9559-9560 -RRB- denotes )
T4783 9560-9561 . denotes .
T4784 9562-9566 NN denotes Flow
T4785 9567-9576 NN denotes cytometry
T4786 9577-9585 NN denotes analysis
T4787 9586-9588 IN denotes of
T4788 9589-9592 DT denotes the
T4789 9593-9606 JJ denotes SCID-passaged
T4790 9607-9616 JJ denotes wild-type
T4791 9617-9620 CC denotes and
T4792 9621-9625 JJ denotes LMP1
T4793 9626-9636 JJ denotes transgenic
T4794 9637-9646 NNS denotes lymphomas
T4795 9647-9655 VBD denotes revealed
T4796 9656-9658 DT denotes an
T4797 9659-9672 NNP denotes IgMhighIgDlow
T4798 9673-9682 NN denotes phenotype
T4799 9683-9684 -LRB- denotes (
T4800 9684-9690 NN denotes Figure
T4801 9691-9693 NN denotes 2A
T4802 9693-9694 -RRB- denotes )
T4803 9694-9695 , denotes ,
T4804 9696-9706 JJ denotes indicative
T4805 9707-9709 IN denotes of
T4806 9710-9718 JJ denotes marginal
T4807 9719-9723 NN denotes zone
T4808 9723-9724 , denotes ,
T4809 9725-9728 JJ denotes B-1
T4810 9728-9729 , denotes ,
T4811 9730-9732 CC denotes or
T4812 9733-9739 NN denotes memory
T4813 9740-9741 NNP denotes B
T4814 9742-9747 NNS denotes cells
T4815 9747-9748 . denotes .
T4816 9749-9752 JJ denotes B-1
T4817 9753-9758 NNS denotes cells
T4818 9759-9762 VBP denotes are
T4819 9763-9770 JJ denotes further
T4820 9771-9780 VBD denotes separated
T4821 9781-9785 IN denotes into
T4822 9786-9789 CD denotes CD5
T4823 9789-9790 NN denotes +
T4824 9791-9792 -LRB- denotes (
T4825 9792-9796 NN denotes B-1a
T4826 9796-9797 -RRB- denotes )
T4827 9798-9801 CC denotes and
T4828 9802-9805 CD denotes CD5
T4829 9805-9806 NN denotes −
T4830 9807-9808 -LRB- denotes (
T4831 9808-9812 JJ denotes B-1b
T4832 9812-9813 -RRB- denotes )
T4833 9814-9821 NNS denotes subsets
T4834 9821-9822 . denotes .
T4835 9823-9825 TO denotes To
T4836 9826-9839 VB denotes differentiate
T4837 9840-9847 IN denotes between
T4838 9848-9853 DT denotes these
T4839 9854-9858 NN denotes cell
T4840 9859-9864 NNS denotes types
T4841 9864-9865 , denotes ,
T4842 9866-9874 NN denotes lymphoma
T4843 9875-9880 NNS denotes cells
T4844 9881-9885 VBD denotes were
T4845 9886-9893 JJ denotes further
T4846 9894-9902 VBD denotes analyzed
T4847 9903-9906 IN denotes for
T4848 9907-9910 DT denotes the
T4849 9911-9915 NN denotes B-1a
T4850 9916-9922 NN denotes marker
T4851 9923-9926 NNP denotes CD5
T4852 9926-9927 . denotes .
T4853 9928-9931 DT denotes All
T4854 9932-9933 -LRB- denotes (
T4855 9933-9936 CD denotes 5/5
T4856 9936-9937 -RRB- denotes )
T4857 9938-9940 IN denotes of
T4858 9941-9944 DT denotes the
T4859 9945-9951 VBN denotes tested
T4860 9952-9956 NNP denotes LMP1
T4861 9957-9967 JJ denotes transgenic
T4862 9968-9977 NNS denotes lymphomas
T4863 9978-9987 VBD denotes displayed
T4864 9988-9990 DT denotes an
T4865 9991-10007 JJ denotes IgMhighIgDlowCD5
T4866 10007-10008 NN denotes +
T4867 10009-10018 NN denotes phenotype
T4868 10019-10020 -LRB- denotes (
T4869 10020-10026 NN denotes Figure
T4870 10027-10029 NN denotes 2A
T4871 10029-10030 -RRB- denotes )
T4872 10030-10031 , denotes ,
T4873 10032-10034 DT denotes an
T4874 10035-10045 NN denotes expression
T4875 10046-10053 NN denotes pattern
T4876 10054-10058 WDT denotes that
T4877 10059-10072 VBZ denotes distinguishes
T4878 10073-10077 JJ denotes B-1a
T4879 10078-10083 NNS denotes cells
T4880 10083-10084 . denotes .
T4881 10085-10098 RB denotes Interestingly
T4882 10098-10099 , denotes ,
T4883 10100-10101 DT denotes a
T4884 10102-10113 JJ denotes spontaneous
T4885 10114-10123 JJ denotes wild-type
T4886 10124-10132 NN denotes lymphoma
T4887 10133-10137 RB denotes also
T4888 10138-10147 VBD denotes developed
T4889 10148-10150 IN denotes in
T4890 10151-10155 JJ denotes B-1a
T4891 10156-10161 NNS denotes cells
T4892 10162-10163 -LRB- denotes (
T4893 10163-10169 NN denotes Figure
T4894 10170-10172 NN denotes 2A
T4895 10172-10173 -RRB- denotes )
T4896 10173-10174 . denotes .
T4897 10175-10180 DT denotes These
T4898 10181-10186 NNS denotes cells
T4899 10187-10190 VBP denotes are
T4900 10191-10193 DT denotes an
T4901 10194-10205 JJ denotes interesting
T4902 10206-10216 NN denotes population
T4903 10217-10221 WDT denotes that
T4904 10222-10224 VBZ denotes is
T4905 10225-10229 NN denotes self
T4906 10230-10242 VBG denotes replenishing
T4907 10243-10247 IN denotes with
T4908 10248-10250 DT denotes an
T4909 10251-10260 VBN denotes increased
T4910 10261-10271 NN denotes likelihood
T4911 10272-10274 TO denotes to
T4912 10275-10281 VB denotes become
T4913 10282-10291 JJ denotes malignant
T4914 10292-10294 IN denotes in
T4915 10295-10299 VBN denotes aged
T4916 10300-10304 NNS denotes mice
T4917 10305-10306 NNP denotes [
T4918 10306-10308 CD denotes 30
T4919 10308-10309 NNP denotes ]
T4920 10309-10310 . denotes .
T4921 10311-10319 NN denotes Analysis
T4922 10320-10322 IN denotes of
T4923 10323-10327 CD denotes LMP1
T4924 10328-10338 JJ denotes transgenic
T4925 10339-10343 NNS denotes mice
T4926 10344-10350 IN denotes before
T4927 10351-10354 DT denotes the
T4928 10355-10366 NN denotes development
T4929 10367-10369 IN denotes of
T4930 10370-10378 NN denotes lymphoma
T4931 10379-10385 VBD denotes showed
T4932 10386-10393 JJ denotes similar
T4933 10394-10401 NNS denotes numbers
T4934 10402-10404 IN denotes of
T4935 10405-10412 JJ denotes splenic
T4936 10413-10417 NN denotes B-1a
T4937 10418-10419 -LRB- denotes (
T4938 10419-10423 CD denotes CD19
T4939 10423-10424 NN denotes +
T4940 10424-10427 CD denotes CD5
T4941 10427-10428 NN denotes +
T4942 10428-10429 -RRB- denotes )
T4943 10430-10433 CC denotes and
T4944 10434-10438 JJ denotes B-1b
T4945 10439-10441 CC denotes or
T4946 10442-10445 JJ denotes B-2
T4947 10446-10457 NNS denotes populations
T4948 10458-10459 -LRB- denotes (
T4949 10459-10463 CD denotes CD19
T4950 10463-10464 NN denotes +
T4951 10464-10467 CD denotes CD5
T4952 10467-10468 NN denotes −
T4953 10468-10469 -RRB- denotes )
T4954 10469-10470 , denotes ,
T4955 10471-10481 VBG denotes indicating
T4956 10482-10486 IN denotes that
T4957 10487-10491 CD denotes LMP1
T4958 10492-10496 VBZ denotes does
T4959 10497-10500 RB denotes not
T4960 10501-10507 VB denotes affect
T4961 10508-10509 NNP denotes B
T4962 10510-10514 NN denotes cell
T4963 10515-10530 NN denotes differentiation
T4964 10531-10532 -LRB- denotes (
T4965 10532-10538 NN denotes Figure
T4966 10539-10541 NN denotes 2B
T4967 10541-10542 -RRB- denotes )
T4968 10542-10543 . denotes .
T4969 11525-11528 JJ denotes Due
T4970 11529-11531 TO denotes to
T4971 11532-11539 JJ denotes allelic
T4972 11540-11549 NN denotes exclusion
T4973 11549-11550 , denotes ,
T4974 11551-11557 VBP denotes mature
T4975 11558-11559 NNP denotes B
T4976 11560-11565 NNS denotes cells
T4977 11566-11570 WDT denotes that
T4978 11571-11575 VBP denotes have
T4979 11576-11580 VBN denotes been
T4980 11581-11588 VBN denotes exposed
T4981 11589-11591 TO denotes to
T4982 11592-11599 NN denotes antigen
T4983 11600-11604 MD denotes will
T4984 11605-11614 RB denotes typically
T4985 11615-11622 VB denotes express
T4986 11623-11627 RB denotes only
T4987 11628-11631 CD denotes one
T4988 11632-11637 JJ denotes heavy
T4989 11638-11643 NN denotes chain
T4990 11644-11651 NN denotes isotype
T4991 11652-11653 -LRB- denotes (
T4992 11653-11656 NNP denotes IgG
T4993 11656-11657 , denotes ,
T4994 11658-11661 NNP denotes IgE
T4995 11661-11662 , denotes ,
T4996 11663-11665 CC denotes or
T4997 11666-11669 NNP denotes IgA
T4998 11669-11670 -RRB- denotes )
T4999 11671-11674 CC denotes and
T5000 11675-11681 RB denotes either
T5001 11682-11683 DT denotes a
T5002 11684-11685 NN denotes κ
T5003 11686-11688 CC denotes or
T5004 11689-11690 NN denotes λ
T5005 11691-11696 NN denotes light
T5006 11697-11702 NN denotes chain
T5007 11702-11703 . denotes .
T5008 11704-11717 RB denotes Interestingly
T5009 11717-11718 , denotes ,
T5010 11719-11722 CD denotes 2/5
T5011 11723-11727 CD denotes LMP1
T5012 11728-11738 JJ denotes transgenic
T5013 11739-11748 NNS denotes lymphomas
T5014 11749-11757 VBD denotes analyzed
T5015 11758-11759 -LRB- denotes (
T5016 11759-11768 NNS denotes lymphomas
T5017 11769-11770 CD denotes 2
T5018 11771-11774 CC denotes and
T5019 11775-11776 CD denotes 4
T5020 11776-11777 -RRB- denotes )
T5021 11778-11782 VBD denotes were
T5022 11783-11789 RB denotes doubly
T5023 11790-11798 JJ denotes positive
T5024 11799-11802 IN denotes for
T5025 11803-11806 JJ denotes low
T5026 11807-11813 NNS denotes levels
T5027 11814-11816 IN denotes of
T5028 11817-11821 DT denotes both
T5029 11822-11823 NN denotes κ
T5030 11824-11827 CC denotes and
T5031 11828-11829 NN denotes λ
T5032 11830-11835 NN denotes light
T5033 11836-11842 NNS denotes chains
T5034 11843-11844 -LRB- denotes (
T5035 11844-11850 NN denotes Figure
T5036 11851-11853 NN denotes 2A
T5037 11853-11854 -RRB- denotes )
T5038 11854-11855 . denotes .
T5039 11856-11864 JJ denotes Previous
T5040 11865-11881 NN denotes characterization
T5041 11882-11884 IN denotes of
T5042 11885-11888 DT denotes the
T5043 11889-11893 NNP denotes LMP1
T5044 11894-11903 NNS denotes lymphomas
T5045 11904-11907 VBD denotes had
T5046 11908-11916 VBN denotes revealed
T5047 11917-11921 IN denotes that
T5048 11922-11925 DT denotes the
T5049 11926-11935 NNS denotes lymphomas
T5050 11936-11940 VBD denotes were
T5051 11941-11947 JJ denotes clonal
T5052 11948-11950 IN denotes as
T5053 11951-11961 VBN denotes determined
T5054 11962-11964 IN denotes by
T5055 11965-11967 NNP denotes Ig
T5056 11968-11973 JJ denotes heavy
T5057 11974-11979 NN denotes chain
T5058 11980-11993 NN denotes rearrangement
T5059 11994-11995 NNP denotes [
T5060 11995-11997 CD denotes 26
T5061 11997-11998 NNP denotes ]
T5062 11998-11999 , denotes ,
T5063 12000-12003 CC denotes and
T5064 12004-12012 NN denotes analysis
T5065 12013-12015 IN denotes of
T5066 12016-12017 NN denotes κ
T5067 12018-12023 NN denotes chain
T5068 12024-12037 NN denotes rearrangement
T5069 12038-12039 -LRB- denotes (
T5070 12039-12045 NN denotes Figure
T5071 12046-12048 CD denotes S1
T5072 12048-12049 -RRB- denotes )
T5073 12050-12052 IN denotes of
T5074 12053-12056 DT denotes the
T5075 12057-12064 NNS denotes samples
T5076 12065-12073 VBD denotes analyzed
T5077 12074-12076 IN denotes in
T5078 12077-12081 DT denotes this
T5079 12082-12087 NN denotes study
T5080 12088-12097 VBD denotes confirmed
T5081 12098-12107 NN denotes clonality
T5082 12107-12108 . denotes .
T5083 12109-12111 TO denotes To
T5084 12112-12119 RBR denotes further
T5085 12120-12126 VB denotes assess
T5086 12127-12132 JJ denotes light
T5087 12133-12138 NN denotes chain
T5088 12139-12149 NN denotes expression
T5089 12149-12150 , denotes ,
T5090 12151-12154 DT denotes the
T5091 12155-12163 JJ denotes passaged
T5092 12164-12171 NNS denotes samples
T5093 12172-12176 VBD denotes were
T5094 12177-12183 VBN denotes tested
T5095 12184-12186 IN denotes by
T5096 12187-12201 VBG denotes immunoblotting
T5097 12202-12205 IN denotes for
T5098 12206-12207 NN denotes κ
T5099 12208-12211 CC denotes and
T5100 12212-12213 NN denotes λ
T5101 12214-12219 NN denotes light
T5102 12220-12226 NNS denotes chains
T5103 12227-12228 -LRB- denotes (
T5104 12228-12234 NN denotes Figure
T5105 12235-12237 CD denotes 2C
T5106 12237-12238 -RRB- denotes )
T5107 12238-12239 . denotes .
T5108 12240-12253 RB denotes Interestingly
T5109 12253-12254 , denotes ,
T5110 12255-12259 RB denotes very
T5111 12260-12263 JJ denotes low
T5112 12264-12270 NNS denotes levels
T5113 12271-12273 IN denotes of
T5114 12274-12284 NN denotes expression
T5115 12285-12287 IN denotes of
T5116 12288-12292 DT denotes both
T5117 12293-12298 JJ denotes light
T5118 12299-12305 NNS denotes chains
T5119 12306-12310 VBD denotes were
T5120 12311-12319 VBN denotes detected
T5121 12320-12322 IN denotes by
T5122 12323-12327 NN denotes flow
T5123 12328-12337 NN denotes cytometry
T5124 12337-12338 . denotes .
T5125 12339-12342 DT denotes The
T5126 12343-12346 JJ denotes low
T5127 12347-12353 NNS denotes levels
T5128 12354-12356 IN denotes of
T5129 12357-12367 NN denotes expression
T5130 12368-12371 MD denotes may
T5131 12372-12379 VB denotes reflect
T5132 12380-12381 DT denotes a
T5133 12382-12392 NN denotes limitation
T5134 12393-12395 IN denotes of
T5135 12396-12399 DT denotes the
T5136 12400-12405 JJ denotes total
T5137 12406-12412 NN denotes number
T5138 12413-12415 IN denotes of
T5139 12416-12421 JJ denotes light
T5140 12422-12428 NNS denotes chains
T5141 12429-12433 WDT denotes that
T5142 12434-12437 MD denotes can
T5143 12438-12440 VB denotes be
T5144 12441-12450 VBN denotes expressed
T5145 12451-12453 IN denotes on
T5146 12454-12457 DT denotes the
T5147 12458-12465 NN denotes surface
T5148 12466-12468 IN denotes of
T5149 12469-12470 DT denotes a
T5150 12471-12472 NNP denotes B
T5151 12473-12477 NN denotes cell
T5152 12477-12478 . denotes .
T5153 12479-12481 IN denotes In
T5154 12482-12491 NN denotes agreement
T5155 12492-12496 IN denotes with
T5156 12497-12500 DT denotes the
T5157 12501-12505 NN denotes flow
T5158 12506-12515 NN denotes cytometry
T5159 12516-12524 NN denotes analysis
T5160 12524-12525 , denotes ,
T5161 12526-12530 NNP denotes LMP1
T5162 12531-12541 JJ denotes transgenic
T5163 12542-12551 NNS denotes lymphomas
T5164 12552-12553 CD denotes 2
T5165 12554-12557 CC denotes and
T5166 12558-12559 CD denotes 4
T5167 12560-12564 VBD denotes were
T5168 12565-12569 RB denotes also
T5169 12570-12578 JJ denotes positive
T5170 12579-12582 IN denotes for
T5171 12583-12584 NN denotes κ
T5172 12585-12588 CC denotes and
T5173 12589-12590 NN denotes λ
T5174 12591-12596 NN denotes light
T5175 12597-12603 NNS denotes chains
T5176 12604-12606 IN denotes by
T5177 12607-12617 NN denotes immunoblot
T5178 12618-12626 NN denotes analysis
T5179 12627-12628 -LRB- denotes (
T5180 12628-12634 NN denotes Figure
T5181 12635-12637 CD denotes 2C
T5182 12637-12638 -RRB- denotes )
T5183 12638-12639 , denotes ,
T5184 12640-12650 VBG denotes confirming
T5185 12651-12655 IN denotes that
T5186 12656-12661 DT denotes these
T5187 12662-12671 NNS denotes lymphomas
T5188 12672-12679 VBP denotes express
T5189 12680-12684 DT denotes both
T5190 12685-12690 JJ denotes light
T5191 12691-12697 NNS denotes chains
T5192 12697-12698 . denotes .
T5193 12699-12700 DT denotes A
T5194 12701-12709 JJ denotes previous
T5195 12710-12715 NN denotes study
T5196 12716-12718 IN denotes of
T5197 12719-12723 NNS denotes mice
T5198 12724-12728 WDT denotes that
T5199 12729-12738 VBD denotes developed
T5200 12739-12747 NN denotes leukemia
T5201 12748-12751 JJ denotes due
T5202 12752-12754 TO denotes to
T5203 12755-12757 DT denotes an
T5204 12758-12767 NN denotes expansion
T5205 12768-12770 IN denotes of
T5206 12771-12784 JJ denotes self-reactive
T5207 12785-12789 JJ denotes B-1a
T5208 12790-12795 NNS denotes cells
T5209 12796-12806 VBD denotes determined
T5210 12807-12811 IN denotes that
T5211 12812-12815 DT denotes the
T5212 12816-12820 NN denotes B-1a
T5213 12821-12830 NNS denotes leukemias
T5214 12831-12835 VBD denotes were
T5245 12997-13003 VB denotes result
T5246 13004-13006 IN denotes in
T5247 13007-13010 DT denotes the
T5248 13011-13019 JJ denotes aberrant
T5249 13020-13026 NN denotes escape
T5250 13027-13031 IN denotes from
T5251 13032-13039 JJ denotes allelic
T5252 13040-13049 NN denotes exclusion
T5253 13049-13050 . denotes .
T6719 8678-8687 NNP denotes wild-type
T6720 9617-9620 CC denotes and
T6721 9621-9625 NNP denotes LMP1
T6722 9626-9636 NNP denotes transgenic
T6723 9637-9645 NNP denotes lymphoma
T6724 17017-17022 NNP denotes Cells
T6725 17023-17025 VBP denotes Do
T6726 17026-17029 RB denotes Not
T6727 17030-17037 VB denotes Require
T6728 17038-17041 NNP denotes IL4
T6729 17042-17045 CC denotes and
T6730 17046-17051 NNP denotes Stat6
T6731 17052-17061 NNP denotes Signaling
T6732 17062-17064 TO denotes To
T6733 17065-17076 VB denotes investigate
T6734 17077-17084 IN denotes whether
T6735 17085-17088 NNP denotes IL4
T6736 17089-17101 NN denotes independence
T6737 17102-17105 VBD denotes was
T6738 17106-17109 JJ denotes due
T6739 17110-17112 TO denotes to
T6740 17113-17123 JJ denotes endogenous
T6741 17124-17127 NNP denotes IL4
T6742 17128-17138 NN denotes expression
T6743 17138-17139 , denotes ,
T6744 17140-17143 NNP denotes IL4
T6745 17144-17157 NN denotes transcription
T6746 17158-17161 VBD denotes was
T6747 17162-17170 VBN denotes assessed
T6748 17171-17173 IN denotes by
T6749 17174-17176 DT denotes an
T6750 17177-17182 JJ denotes Rnase
T6751 17183-17193 NN denotes protection
T6752 17194-17199 NN denotes assay
T6753 17200-17201 -LRB- denotes (
T6754 17201-17204 NNP denotes RPA
T6755 17204-17205 -RRB- denotes )
T6756 17205-17206 . denotes .
T6757 17207-17210 CD denotes IL4
T6758 17211-17224 NN denotes transcription
T6759 17225-17228 VBD denotes was
T6760 17229-17239 JJ denotes detectable
T6761 17240-17244 IN denotes with
T6762 17245-17252 NN denotes control
T6763 17253-17256 NNP denotes RNA
T6764 17257-17260 CC denotes and
T6765 17261-17268 RB denotes faintly
T6766 17269-17271 IN denotes in
T6767 17272-17275 DT denotes the
T6768 17276-17281 NN denotes mouse
T6769 17282-17290 NN denotes lymphoma
T6770 17291-17295 NN denotes cell
T6771 17296-17300 NN denotes line
T6772 17301-17305 NNP denotes K46μ
T6773 17306-17307 -LRB- denotes (
T6774 17307-17313 NNP denotes Figure
T6775 17314-17316 NNP denotes 4A
T6776 17316-17317 -RRB- denotes )
T6777 17317-17318 . denotes .
T6778 17319-17326 RB denotes However
T6779 17326-17327 , denotes ,
T6780 17328-17331 NNP denotes IL4
T6781 17332-17345 NN denotes transcription
T6782 17346-17349 VBD denotes was
T6783 17350-17353 RB denotes not
T6784 17354-17364 JJ denotes detectable
T6785 17365-17367 IN denotes in
T6786 17368-17372 NNP denotes CD19
T6787 17372-17373 NNP denotes +
T6788 17374-17387 NNP denotes MACS-purified
T6789 17388-17389 NNP denotes B
T6790 17390-17395 NNS denotes cells
T6791 17396-17400 IN denotes from
T6792 17401-17410 JJ denotes wild-type
T6793 17411-17422 NNS denotes lymphocytes
T6794 17423-17424 -LRB- denotes (
T6795 17424-17435 JJ denotes unpublished
T6796 17436-17440 NNS denotes data
T6797 17440-17441 -RRB- denotes )
T6798 17441-17442 , denotes ,
T6799 17443-17447 NNP denotes LMP1
T6800 17448-17458 JJ denotes transgenic
T6801 17459-17470 NNS denotes lymphocytes
T6802 17470-17471 , denotes ,
T6803 17472-17474 CC denotes or
T6804 17475-17483 NN denotes lymphoma
T6805 17484-17489 NNS denotes cells
T6806 17489-17490 , denotes ,
T6807 17491-17499 IN denotes although
T6808 17500-17503 DT denotes the
T6809 17504-17509 NNP denotes GAPDH
T6810 17510-17513 CC denotes and
T6811 17514-17517 NNP denotes L32
T6812 17518-17526 NNS denotes controls
T6813 17527-17531 VBD denotes were
T6814 17532-17543 RB denotes effectively
T6815 17544-17553 VBN denotes protected
T6816 17554-17555 -LRB- denotes (
T6817 17555-17561 NN denotes Figure
T6818 17562-17564 NN denotes 4A
T6819 17564-17565 -RRB- denotes )
T6820 17565-17566 . denotes .
T6821 17567-17576 VBN denotes Activated
T6822 17577-17582 NNP denotes Stat6
T6823 17583-17584 -LRB- denotes (
T6824 17584-17590 NNP denotes pStat6
T6825 17590-17591 -RRB- denotes )
T6826 17591-17592 , denotes ,
T6827 17593-17594 DT denotes a
T6828 17595-17601 NN denotes target
T6829 17602-17604 IN denotes of
T6830 17605-17608 DT denotes the
T6831 17609-17612 NN denotes IL4
T6832 17613-17621 NN denotes receptor
T6833 17622-17629 NN denotes pathway
T6834 17629-17630 , denotes ,
T6835 17631-17634 VBD denotes was
T6836 17635-17643 VBN denotes detected
T6837 17644-17646 IN denotes in
T6838 17647-17650 DT denotes the
T6839 17651-17660 JJ denotes wild-type
T6840 17661-17664 CC denotes and
T6841 17665-17669 JJ denotes LMP1
T6842 17670-17680 JJ denotes transgenic
T6843 17681-17692 NNS denotes lymphocytes
T6844 17693-17694 -LRB- denotes (
T6845 17694-17700 NN denotes Figure
T6846 17701-17703 NN denotes 4B
T6847 17703-17704 -RRB- denotes )
T6848 17704-17705 . denotes .
T6849 17706-17708 IN denotes In
T6850 17709-17717 NN denotes contrast
T6851 17717-17718 , denotes ,
T6852 17719-17725 NNP denotes pStat6
T6853 17726-17729 VBD denotes was
T6854 17730-17736 RB denotes barely
T6855 17737-17745 VBN denotes detected
T6856 17746-17748 IN denotes in
T6857 17749-17755 CC denotes either
T6858 17756-17759 DT denotes the
T6859 17760-17769 JJ denotes wild-type
T6860 17770-17772 CC denotes or
T6861 17773-17777 JJ denotes LMP1
T6862 17778-17788 JJ denotes transgenic
T6863 17789-17797 NN denotes lymphoma
T6864 17798-17803 NNS denotes cells
T6865 17803-17804 . denotes .
T6866 17805-17812 RB denotes However
T6867 17812-17813 , denotes ,
T6868 17814-17817 DT denotes the
T6869 17818-17825 NN denotes pathway
T6870 17826-17829 VBD denotes was
T6871 17830-17833 RB denotes not
T6872 17834-17842 JJ denotes disabled
T6873 17842-17843 , denotes ,
T6874 17844-17846 IN denotes as
T6875 17847-17856 NN denotes treatment
T6876 17857-17859 IN denotes of
T6877 17860-17863 DT denotes the
T6878 17864-17872 NN denotes lymphoma
T6879 17873-17878 NNS denotes cells
T6880 17879-17883 IN denotes with
T6881 17884-17887 NNP denotes IL4
T6882 17888-17895 VBD denotes induced
T6883 17896-17901 NNP denotes Stat6
T6884 17902-17917 NN denotes phosphorylation
T6885 17918-17919 -LRB- denotes (
T6886 17919-17925 NN denotes Figure
T6887 17926-17928 NN denotes 4C
T6888 17928-17929 -RRB- denotes )
T6889 17929-17930 . denotes .
T6890 18976-18984 IN denotes Although
T6891 18985-18994 JJ denotes wild-type
T6892 18995-19006 NNS denotes lymphocytes
T6893 19007-19010 MD denotes can
T6894 19010-19013 RB denotes not
T6895 19014-19016 VB denotes be
T6896 19017-19027 VBN denotes maintained
T6897 19028-19030 IN denotes in
T6898 19031-19038 NN denotes culture
T6899 19039-19043 IN denotes with
T6900 19044-19047 CD denotes IL4
T6901 19048-19063 NN denotes supplementation
T6902 19064-19069 RB denotes alone
T6903 19070-19071 -LRB- denotes (
T6904 19071-19077 NN denotes Figure
T6905 19078-19080 NN denotes 3A
T6906 19080-19081 -RRB- denotes )
T6907 19081-19082 , denotes ,
T6908 19083-19089 JJ denotes slight
T6909 19090-19101 NN denotes enhancement
T6910 19102-19104 IN denotes in
T6911 19105-19108 NNP denotes MTS
T6912 19109-19117 NN denotes activity
T6913 19118-19123 MD denotes could
T6914 19124-19126 VB denotes be
T6915 19127-19135 VBN denotes detected
T6916 19136-19138 IN denotes if
T6917 19139-19142 DT denotes the
T6918 19143-19148 NNS denotes cells
T6919 19149-19153 VBD denotes were
T6920 19154-19162 VBN denotes analyzed
T6921 19163-19165 IN denotes at
T6922 19166-19168 DT denotes an
T6923 19169-19176 JJR denotes earlier
T6924 19177-19181 NN denotes time
T6925 19182-19187 NN denotes point
T6926 19187-19188 , denotes ,
T6927 19189-19191 IN denotes at
T6928 19192-19193 CD denotes 1
T6929 19194-19195 LS denotes d
T6930 19196-19197 -LRB- denotes (
T6931 19197-19203 NN denotes Figure
T6932 19204-19206 CD denotes 4D
T6933 19206-19207 -RRB- denotes )
T6934 19208-19214 CC denotes versus
T6935 19215-19216 CD denotes 3
T6936 19217-19218 LS denotes d
T6937 19219-19220 -LRB- denotes (
T6938 19220-19226 NNP denotes Figure
T6939 19227-19229 NNP denotes 3A
T6940 19229-19230 -RRB- denotes )
T6941 19231-19243 JJS denotes post-harvest
T6942 19243-19244 . denotes .
T6943 19245-19248 DT denotes The
T6944 19249-19260 NN denotes enhancement
T6945 19261-19263 IN denotes of
T6946 19264-19267 NNP denotes MTS
T6947 19268-19276 NN denotes activity
T6948 19277-19284 VBN denotes induced
T6949 19285-19287 IN denotes by
T6950 19288-19291 NNP denotes IL4
T6951 19292-19294 IN denotes in
T6952 19295-19304 JJ denotes wild-type
T6953 19305-19316 NNS denotes lymphocytes
T6954 19317-19322 MD denotes could
T6955 19323-19325 VB denotes be
T6956 19326-19337 VBN denotes neutralized
T6957 19338-19340 IN denotes by
T6958 19341-19344 DT denotes the
T6959 19345-19353 NN denotes addition
T6960 19354-19356 IN denotes of
T6961 19357-19360 CD denotes IL4
T6962 19361-19369 NN denotes antibody
T6963 19370-19371 -LRB- denotes (
T6964 19371-19377 NN denotes Figure
T6965 19378-19380 CD denotes 4D
T6966 19380-19381 -RRB- denotes )
T6967 19381-19382 . denotes .
T6968 19383-19390 RB denotes However
T6969 19390-19391 , denotes ,
T6970 19392-19404 VBG denotes neutralizing
T6971 19405-19415 NNS denotes antibodies
T6972 19416-19418 TO denotes to
T6973 19419-19422 NNP denotes IL4
T6974 19423-19426 VBD denotes did
T6975 19427-19430 RB denotes not
T6976 19431-19437 VB denotes affect
T6977 19438-19441 DT denotes the
T6978 19442-19445 NNP denotes MTS
T6979 19446-19454 NN denotes activity
T6980 19455-19457 IN denotes of
T6981 19458-19462 CD denotes LMP1
T6982 19463-19473 JJ denotes transgenic
T6983 19474-19482 NN denotes lymphoma
T6984 19483-19488 NNS denotes cells
T6985 19489-19490 -LRB- denotes (
T6986 19490-19496 NN denotes Figure
T6987 19497-19499 CD denotes 4E
T6988 19499-19500 -RRB- denotes )
T6989 19500-19501 . denotes .
T6990 19502-19504 IN denotes In
T6991 19505-19512 NN denotes summary
T6992 19512-19513 , denotes ,
T6993 19514-19517 DT denotes the
T6994 19518-19527 JJ denotes wild-type
T6995 19528-19531 CC denotes and
T6996 19532-19536 JJ denotes LMP1
T6997 19537-19547 JJ denotes transgenic
T6998 19548-19556 NN denotes lymphoma
T6999 19557-19562 NNS denotes cells
T7000 19563-19567 VBD denotes grew
T7001 19568-19581 RB denotes independently
T7002 19582-19584 IN denotes of
T7003 19585-19588 CD denotes IL4
T7004 19589-19598 NN denotes treatment
T7005 19599-19602 CC denotes and
T7006 19603-19606 VBD denotes did
T7007 19607-19610 RB denotes not
T7008 19611-19618 VB denotes require
T7009 19619-19624 JJ denotes Stat6
T7010 19625-19634 VBG denotes signaling
T7011 19634-19635 . denotes .
T8264 19637-19641 CD denotes LMP1
T8265 19642-19653 NNPS denotes Upregulates
T8266 19654-19658 NNP denotes IL10
T8267 19659-19662 CC denotes and
T8268 19663-19677 NNP denotes Constitutively
T8269 19678-19687 NNP denotes Activates
T8270 19688-19693 NNP denotes Stat3
T8271 19694-19696 TO denotes To
T8272 19697-19705 VB denotes identify
T8273 19706-19715 NNS denotes cytokines
T8274 19716-19720 WDT denotes that
T8275 19721-19724 MD denotes may
T8276 19725-19735 VB denotes contribute
T8277 19736-19738 TO denotes to
T8278 19739-19742 DT denotes the
T8279 19743-19752 VBN denotes increased
T8280 19753-19761 NN denotes survival
T8281 19762-19765 CC denotes and
T8282 19766-19772 NN denotes growth
T8283 19773-19775 IN denotes of
T8284 19776-19785 NNS denotes lymphomas
T8285 19785-19786 , denotes ,
T8286 19787-19790 DT denotes the
T8287 19791-19801 NN denotes expression
T8288 19802-19808 NNS denotes levels
T8289 19809-19811 IN denotes of
T8290 19812-19813 DT denotes a
T8291 19814-19819 NN denotes panel
T8292 19820-19822 IN denotes of
T8293 19823-19832 NNS denotes cytokines
T8294 19833-19837 VBD denotes were
T8295 19838-19846 VBN denotes screened
T8296 19847-19849 IN denotes on
T8297 19850-19854 NNP denotes CD19
T8298 19854-19855 NNP denotes +
T8299 19856-19869 NNP denotes MACS-purified
T8300 19870-19871 NNP denotes B
T8301 19872-19877 NNS denotes cells
T8302 19877-19878 , denotes ,
T8303 19879-19884 VBG denotes using
T8304 19885-19887 DT denotes an
T8305 19888-19891 NNP denotes RPA
T8306 19892-19897 NN denotes probe
T8307 19898-19901 NN denotes set
T8308 19902-19905 IN denotes for
T8309 19906-19909 NNP denotes IL4
T8310 19909-19910 , denotes ,
T8311 19911-19914 NNP denotes IL5
T8312 19914-19915 , denotes ,
T8313 19916-19920 NNP denotes IL10
T8314 19920-19921 , denotes ,
T8315 19922-19926 NNP denotes IL13
T8316 19926-19927 , denotes ,
T8317 19928-19932 NNP denotes IL15
T8318 19932-19933 , denotes ,
T8319 19934-19937 NNP denotes IL9
T8320 19937-19938 , denotes ,
T8321 19939-19942 NNP denotes IL2
T8322 19942-19943 , denotes ,
T8323 19944-19947 NNP denotes IL6
T8324 19947-19948 , denotes ,
T8325 19949-19952 CC denotes and
T8326 19953-19957 NNP denotes IFNγ
T8327 19957-19958 . denotes .
T8328 19959-19969 NN denotes Expression
T8329 19970-19976 NNS denotes levels
T8330 19977-19981 VBD denotes were
T8331 19982-19992 VBN denotes quantified
T8332 19993-19997 IN denotes with
T8333 19998-19999 DT denotes a
T8334 20000-20014 NN denotes phosphorimager
T8335 20015-20018 CC denotes and
T8336 20019-20029 VBN denotes normalized
T8337 20030-20032 TO denotes to
T8338 20033-20036 DT denotes the
T8339 20037-20046 JJ denotes ribosomal
T8340 20047-20059 NN denotes housekeeping
T8341 20060-20064 NN denotes gene
T8342 20065-20068 NNP denotes L32
T8343 20068-20069 . denotes .
T8344 20070-20074 NN denotes None
T8345 20075-20077 IN denotes of
T8346 20078-20081 DT denotes the
T8347 20082-20088 VBN denotes tested
T8348 20089-20098 NNS denotes cytokines
T8349 20099-20103 VBD denotes were
T8350 20104-20112 VBN denotes detected
T8351 20113-20115 IN denotes in
T8352 20116-20125 JJ denotes wild-type
T8353 20126-20137 NNS denotes lymphocytes
T8354 20137-20138 , denotes ,
T8355 20139-20148 RB denotes therefore
T8356 20149-20157 NN denotes cytokine
T8357 20157-20158 : denotes :
T8358 20158-20161 JJ denotes L32
T8359 20162-20168 NNS denotes ratios
T8360 20169-20173 VBD denotes were
T8361 20174-20177 VBN denotes set
T8362 20178-20180 TO denotes to
T8363 20181-20182 CD denotes 1
T8364 20183-20185 IN denotes in
T8365 20186-20189 DT denotes the
T8366 20190-20195 NN denotes mouse
T8367 20196-20197 NNP denotes B
T8368 20198-20202 NN denotes cell
T8369 20203-20211 NN denotes lymphoma
T8370 20212-20216 NN denotes line
T8371 20217-20220 CD denotes 967
T8372 20220-20221 . denotes .
T8373 20222-20235 NNP denotes Transcription
T8374 20236-20238 IN denotes of
T8375 20239-20243 NNP denotes IL10
T8376 20243-20244 , denotes ,
T8377 20245-20249 NNP denotes IL15
T8378 20249-20250 , denotes ,
T8379 20251-20254 CC denotes and
T8380 20255-20259 NNP denotes IFNγ
T8381 20260-20264 VBD denotes were
T8382 20265-20277 RB denotes reproducibly
T8383 20278-20286 VBN denotes detected
T8384 20287-20289 IN denotes in
T8385 20290-20294 CD denotes LMP1
T8386 20295-20305 JJ denotes transgenic
T8387 20306-20317 NNS denotes lymphocytes
T8388 20318-20321 CC denotes and
T8389 20322-20330 NN denotes lymphoma
T8390 20331-20336 NNS denotes cells
T8391 20337-20340 CC denotes and
T8392 20341-20344 VBD denotes was
T8393 20345-20351 JJR denotes higher
T8394 20352-20356 IN denotes than
T8395 20357-20359 IN denotes in
T8396 20360-20363 DT denotes the
T8397 20364-20365 NNP denotes B
T8398 20366-20370 NN denotes cell
T8399 20371-20379 NN denotes lymphoma
T8400 20380-20384 NN denotes cell
T8401 20385-20390 NNS denotes lines
T8402 20391-20394 CD denotes 967
T8403 20395-20398 CC denotes and
T8404 20399-20403 NNP denotes K46μ
T8405 20404-20405 -LRB- denotes (
T8406 20405-20411 NNP denotes Figure
T8407 20412-20414 NNP denotes 5A
T8408 20414-20415 -RRB- denotes )
T8409 20415-20416 . denotes .
T8410 20417-20422 EX denotes There
T8411 20423-20426 VBD denotes was
T8412 20427-20429 DT denotes no
T8413 20430-20441 JJ denotes significant
T8414 20442-20452 NN denotes difference
T8415 20453-20455 IN denotes in
T8416 20456-20459 DT denotes the
T8417 20460-20470 NN denotes expression
T8418 20471-20473 IN denotes of
T8419 20474-20478 NNP denotes IL15
T8420 20479-20482 CC denotes and
T8421 20483-20487 NNP denotes IFNγ
T8422 20488-20495 IN denotes between
T8423 20496-20500 NNP denotes LMP1
T8424 20501-20511 JJ denotes transgenic
T8425 20512-20523 NNS denotes lymphocytes
T8426 20524-20527 CC denotes and
T8427 20528-20536 NN denotes lymphoma
T8428 20537-20542 NNS denotes cells
T8429 20542-20543 , denotes ,
T8430 20544-20554 VBG denotes suggesting
T8431 20555-20559 IN denotes that
T8432 20560-20572 NN denotes upregulation
T8433 20573-20575 IN denotes of
T8434 20576-20580 CD denotes IL15
T8435 20581-20584 CC denotes and
T8436 20585-20589 NNP denotes IFNγ
T8437 20590-20592 VBZ denotes is
T8438 20593-20600 VBN denotes induced
T8439 20601-20603 IN denotes by
T8440 20604-20608 CD denotes LMP1
T8441 20609-20619 NN denotes expression
T8442 20620-20622 IN denotes in
T8443 20623-20630 JJ denotes healthy
T8444 20631-20642 NNS denotes lymphocytes
T8445 20643-20646 CC denotes but
T8446 20647-20649 VBZ denotes is
T8447 20650-20653 RB denotes not
T8448 20654-20655 DT denotes a
T8449 20656-20662 JJ denotes unique
T8450 20663-20671 NN denotes property
T8451 20672-20674 IN denotes of
T8452 20675-20684 JJ denotes malignant
T8453 20685-20696 NNS denotes lymphocytes
T8454 20696-20697 . denotes .
T8455 20698-20708 RB denotes Strikingly
T8456 20708-20709 , denotes ,
T8457 20710-20714 NNP denotes IL10
T8458 20714-20715 , denotes ,
T8459 20716-20717 DT denotes a
T8460 20718-20719 NNP denotes B
T8461 20720-20730 NN denotes lymphocyte
T8462 20731-20742 JJ denotes stimulatory
T8463 20743-20751 NN denotes cytokine
T8464 20751-20752 , denotes ,
T8465 20753-20756 VBD denotes was
T8466 20757-20766 VBN denotes increased
T8467 20767-20770 CD denotes 1.5
T8468 20770-20771 : denotes -
T8469 20772-20774 TO denotes to
T8470 20775-20781 JJ denotes 5-fold
T8471 20782-20784 IN denotes in
T8472 20785-20788 DT denotes the
T8473 20789-20798 JJ denotes wild-type
T8474 20799-20802 CC denotes and
T8475 20803-20807 JJ denotes LMP1
T8476 20808-20818 JJ denotes transgenic
T8477 20819-20827 NN denotes lymphoma
T8478 20828-20833 NNS denotes cells
T8479 20834-20842 VBN denotes compared
T8480 20843-20845 TO denotes to
T8481 20846-20850 CD denotes LMP1
T8482 20851-20861 JJ denotes transgenic
T8483 20862-20873 NNS denotes lymphocytes
T8484 20874-20875 -LRB- denotes (
T8485 20875-20881 NN denotes Figure
T8486 20882-20884 NN denotes 5A
T8487 20884-20885 -RRB- denotes )
T8488 20885-20886 . denotes .
T8489 20887-20897 NN denotes Production
T8490 20898-20900 IN denotes of
T8491 20901-20905 CD denotes IL15
T8492 20906-20909 CC denotes and
T8493 20910-20914 NNP denotes IFNγ
T8494 20915-20918 VBZ denotes has
T8495 20919-20923 VBN denotes been
T8496 20924-20934 VBN denotes associated
T8497 20935-20939 IN denotes with
T8498 20940-20949 NN denotes induction
T8499 20950-20952 IN denotes of
T8500 20953-20962 JJ denotes cytotoxic
T8501 20963-20971 NN denotes effector
T8502 20972-20981 NNS denotes responses
T8503 20982-20984 IN denotes in
T8504 20985-20990 NNS denotes cells
T8505 20991-20999 RB denotes latently
T8506 21000-21008 VBN denotes infected
T8507 21009-21013 IN denotes with
T8508 21014-21017 NNP denotes EBV
T8509 21018-21019 NNP denotes [
T8510 21019-21024 CD denotes 33,34
T8511 21024-21025 NNP denotes ]
T8512 21025-21026 . denotes .
T8513 21027-21034 RB denotes However
T8514 21034-21035 , denotes ,
T8515 21036-21050 NN denotes transformation
T8516 21051-21054 CC denotes and
T8517 21055-21061 NN denotes growth
T8518 21062-21072 NNS denotes properties
T8519 21073-21080 VBN denotes induced
T8520 21081-21083 IN denotes by
T8521 21084-21087 NNP denotes EBV
T8522 21088-21091 VBP denotes are
T8523 21092-21102 VBN denotes associated
T8524 21103-21107 IN denotes with
T8525 21108-21111 DT denotes the
T8526 21112-21124 NN denotes upregulation
T8527 21125-21127 IN denotes of
T8528 21128-21132 NNP denotes IL10
T8529 21133-21134 NNP denotes [
T8530 21134-21136 CD denotes 35
T8531 21137-21139 CD denotes 38
T8532 21139-21140 NN denotes ]
T8533 21140-21141 : denotes ;
T8534 21142-21147 RB denotes hence
T8535 21147-21148 , denotes ,
T8536 21149-21152 DT denotes the
T8537 21153-21160 NNS denotes effects
T8538 21161-21163 IN denotes of
T8539 21164-21168 NNP denotes IL10
T8540 21169-21181 NN denotes upregulation
T8541 21182-21184 IN denotes on
T8542 21185-21188 DT denotes the
T8543 21189-21195 NN denotes growth
T8544 21196-21206 NNS denotes properties
T8545 21207-21209 IN denotes of
T8546 21210-21213 DT denotes the
T8547 21214-21222 NN denotes lymphoma
T8548 21223-21228 NNS denotes cells
T8549 21229-21233 VBD denotes were
T8550 21234-21241 JJ denotes further
T8551 21242-21250 VBD denotes examined
T8552 21250-21251 . denotes .
T8553 21252-21262 NNP denotes Immunoblot
T8554 21263-21271 NN denotes analysis
T8555 21272-21281 VBD denotes indicated
T8556 21282-21286 IN denotes that
T8557 21287-21291 CD denotes LMP1
T8558 21292-21302 JJ denotes transgenic
T8559 21303-21314 NNS denotes lymphocytes
T8560 21315-21318 CC denotes and
T8561 21319-21328 JJ denotes wild-type
T8562 21329-21332 CC denotes and
T8563 21333-21337 JJ denotes LMP1
T8564 21338-21348 JJ denotes transgenic
T8565 21349-21357 NN denotes lymphoma
T8566 21358-21363 NNS denotes cells
T8567 21364-21367 VBD denotes had
T8568 21368-21381 JJ denotes corresponding
T8569 21382-21391 VBN denotes increased
T8570 21392-21398 NNS denotes levels
T8571 21399-21401 IN denotes of
T8572 21402-21416 VBN denotes phosphorylated
T8573 21417-21418 NN denotes α
T8574 21419-21422 CC denotes and
T8575 21423-21424 NN denotes β
T8576 21425-21433 NNS denotes isoforms
T8577 21434-21436 IN denotes of
T8578 21437-21446 VBN denotes activated
T8579 21447-21452 NNP denotes Stat3
T8580 21452-21453 , denotes ,
T8581 21454-21455 DT denotes a
T8582 21456-21462 NN denotes target
T8583 21463-21465 IN denotes of
T8584 21466-21469 DT denotes the
T8585 21470-21474 NN denotes IL10
T8586 21475-21483 NN denotes receptor
T8587 21484-21485 -LRB- denotes (
T8588 21485-21491 NN denotes Figure
T8589 21492-21494 NN denotes 5B
T8590 21494-21495 -RRB- denotes )
T8591 21495-21496 . denotes .
T8592 21497-21504 RB denotes However
T8593 21504-21505 , denotes ,
T8594 21506-21510 WRB denotes when
T8595 21511-21520 VBG denotes comparing
T8596 21521-21524 DT denotes the
T8597 21525-21529 JJ denotes same
T8598 21530-21539 NNS denotes lymphomas
T8599 21539-21540 , denotes ,
T8600 21541-21546 EX denotes there
T8601 21547-21550 VBD denotes was
T8602 21551-21553 DT denotes no
T8603 21554-21565 NN denotes correlation
T8604 21566-21573 IN denotes between
T8605 21574-21577 DT denotes the
T8606 21578-21584 NNS denotes levels
T8607 21585-21587 IN denotes of
T8608 21588-21592 NNP denotes IL10
T8609 21593-21602 NN denotes induction
T8610 21603-21606 CC denotes and
T8611 21607-21610 DT denotes the
T8612 21611-21617 NNS denotes levels
T8613 21618-21620 IN denotes of
T8614 21621-21626 JJ denotes Stat3
T8615 21627-21637 NN denotes activation
T8616 21637-21638 . denotes .
T8617 21639-21643 DT denotes This
T8618 21644-21652 VBZ denotes suggests
T8619 21653-21657 IN denotes that
T8620 21658-21661 DT denotes the
T8621 21662-21672 NN denotes activation
T8622 21673-21675 IN denotes of
T8623 21676-21681 NNP denotes Stat3
T8624 21682-21684 VBZ denotes is
T8625 21685-21688 RB denotes not
T8626 21689-21695 RB denotes solely
T8627 21696-21703 VBN denotes induced
T8628 21704-21706 IN denotes by
T8629 21707-21711 CD denotes IL10
T8630 21712-21714 CC denotes or
T8631 21715-21719 DT denotes that
T8632 21720-21725 JJ denotes Stat3
T8633 21726-21736 NN denotes activation
T8634 21737-21740 MD denotes may
T8635 21741-21743 VB denotes be
T8636 21744-21756 JJ denotes constitutive
T8637 21756-21757 . denotes .
T8638 21758-21770 RB denotes Additionally
T8639 21770-21771 , denotes ,
T8640 21772-21777 EX denotes there
T8641 21778-21781 VBD denotes was
T8642 21782-21784 DT denotes no
T8643 21785-21796 NN denotes correlation
T8644 21797-21804 IN denotes between
T8645 21805-21808 DT denotes the
T8646 21809-21815 NNS denotes levels
T8647 21816-21818 IN denotes of
T8648 21819-21823 CD denotes LMP1
T8649 21824-21834 NN denotes expression
T8650 21835-21838 CC denotes and
T8651 21839-21842 DT denotes the
T8652 21843-21849 NNS denotes levels
T8653 21850-21852 IN denotes of
T8654 21853-21857 NNP denotes IL10
T8655 21858-21867 NN denotes induction
T8656 21868-21869 -LRB- denotes (
T8657 21869-21876 NNS denotes Figures
T8658 21877-21879 NNP denotes 1A
T8659 21880-21883 CC denotes and
T8660 21884-21886 NNP denotes 5A
T8661 21886-21887 -RRB- denotes )
T8662 21887-21888 . denotes .
T8663 21889-21893 DT denotes This
T8664 21894-21903 VBZ denotes indicates
T8665 21904-21908 IN denotes that
T8666 21909-21912 DT denotes the
T8667 21913-21922 NN denotes induction
T8668 21923-21925 IN denotes of
T8669 21926-21930 NNP denotes IL10
T8670 21931-21933 VBZ denotes is
T8671 21934-21935 DT denotes a
T8672 21936-21943 JJ denotes general
T8673 21944-21952 NN denotes property
T8674 21953-21963 VBN denotes associated
T8675 21964-21968 IN denotes with
T8676 21969-21977 JJ denotes enhanced
T8677 21978-21986 NN denotes survival
T8678 21987-21990 CC denotes and
T8679 21991-21994 MD denotes may
T8680 21995-21999 RB denotes only
T8681 22000-22002 VB denotes be
T8682 22003-22013 RB denotes indirectly
T8683 22014-22022 VBN denotes affected
T8684 22023-22025 IN denotes by
T8685 22026-22030 NNP denotes LMP1
T8686 22030-22031 . denotes .
T8687 22032-22044 VBG denotes Neutralizing
T8688 22045-22055 NNS denotes antibodies
T8689 22056-22058 TO denotes to
T8690 22059-22063 NNP denotes IL10
T8691 22064-22067 VBD denotes did
T8692 22068-22071 RB denotes not
T8693 22072-22078 VB denotes affect
T8694 22079-22082 DT denotes the
T8695 22083-22091 NN denotes survival
T8696 22092-22094 IN denotes of
T8697 22095-22103 NN denotes lymphoma
T8698 22104-22109 NNS denotes cells
T8699 22110-22112 IN denotes as
T8700 22113-22123 VBN denotes determined
T8701 22124-22126 IN denotes by
T8702 22127-22130 DT denotes the
T8703 22131-22134 NNP denotes MTS
T8704 22135-22140 NN denotes assay
T8705 22141-22142 -LRB- denotes (
T8706 22142-22153 JJ denotes unpublished
T8707 22154-22158 NNS denotes data
T8708 22158-22159 -RRB- denotes )
T8709 22159-22160 , denotes ,
T8710 22161-22171 VBG denotes suggesting
T8711 22172-22184 JJ denotes constitutive
T8712 22185-22195 NN denotes activation
T8713 22196-22198 IN denotes of
T8714 22199-22204 NNP denotes Stat3
T8715 22204-22205 . denotes .
T8716 22206-22210 DT denotes This
T8717 22211-22214 VBD denotes was
T8718 22215-22224 VBN denotes confirmed
T8719 22225-22227 IN denotes by
T8720 22228-22238 NN denotes immunoblot
T8721 22239-22247 NN denotes analysis
T8722 22248-22252 JJ denotes such
T8723 22253-22257 IN denotes that
T8724 22258-22260 IN denotes in
T8725 22261-22264 DT denotes the
T8726 22265-22273 NN denotes presence
T8727 22274-22276 IN denotes of
T8728 22277-22286 JJ denotes anti-IL10
T8729 22287-22299 VBG denotes neutralizing
T8730 22300-22310 NNS denotes antibodies
T8731 22310-22311 , denotes ,
T8732 22312-22318 JJ denotes pStat3
T8733 22319-22325 NNS denotes levels
T8734 22326-22334 VBD denotes remained
T8735 22335-22344 VBN denotes activated
T8736 22345-22347 IN denotes in
T8737 22348-22356 NN denotes lymphoma
T8738 22357-22362 NNS denotes cells
T8739 22363-22371 VBN denotes isolated
T8740 22372-22376 IN denotes from
T8741 22377-22386 JJ denotes wild-type
T8742 22387-22390 CC denotes and
T8743 22391-22395 JJ denotes LMP1
T8744 22396-22406 JJ denotes transgenic
T8745 22407-22416 NNS denotes lymphomas
T8746 22417-22418 -LRB- denotes (
T8747 22418-22424 NN denotes Figure
T8748 22425-22427 NN denotes 5C
T8749 22427-22428 -RRB- denotes )
T8750 22428-22429 . denotes .
T8751 22430-22439 JJ denotes Exogenous
T8752 22440-22448 NN denotes addition
T8753 22449-22451 IN denotes of
T8754 22452-22456 CD denotes IL10
T8755 22457-22465 JJ denotes enhanced
T8756 22466-22472 JJ denotes pStat3
T8757 22473-22483 NN denotes activation
T8758 22484-22489 IN denotes above
T8759 22490-22502 JJ denotes constitutive
T8760 22503-22509 NNS denotes levels
T8761 22509-22510 , denotes ,
T8762 22511-22521 VBG denotes indicating
T8763 22522-22526 IN denotes that
T8764 22527-22535 NN denotes lymphoma
T8765 22536-22541 NNS denotes cells
T8766 22542-22545 VBP denotes are
T8767 22546-22556 JJ denotes responsive
T8768 22557-22559 TO denotes to
T8769 22560-22564 NNP denotes IL10
T8770 22565-22574 NN denotes treatment
T8771 22575-22576 -LRB- denotes (
T8772 22576-22582 NN denotes Figure
T8773 22583-22585 NN denotes 5C
T8774 22585-22586 -RRB- denotes )
T8775 22586-22587 . denotes .
T8776 22588-22592 DT denotes This
T8777 22593-22598 VBZ denotes means
T8778 22599-22603 IN denotes that
T8779 22604-22612 IN denotes although
T8780 22613-22616 DT denotes the
T8781 22617-22625 NN denotes lymphoma
T8782 22626-22631 NNS denotes cells
T8783 22632-22636 VBP denotes have
T8784 22637-22649 JJ denotes constitutive
T8785 22650-22655 JJ denotes Stat3
T8786 22656-22666 NN denotes activation
T8787 22666-22667 , denotes ,
T8788 22668-22670 PRP denotes it
T8789 22671-22674 MD denotes may
T8790 22675-22677 VB denotes be
T8791 22678-22685 JJ denotes further
T8792 22686-22694 VBN denotes enhanced
T8793 22695-22697 IN denotes by
T8794 22698-22702 NNP denotes IL10
T8795 22703-22712 NN denotes induction
T8796 22712-22713 . denotes .
T8797 22714-22717 DT denotes The
T8798 22718-22730 VBG denotes neutralizing
T8799 22731-22737 NN denotes effect
T8800 22738-22740 IN denotes of
T8801 22741-22744 DT denotes the
T8802 22745-22754 JJ denotes anti-IL10
T8803 22755-22763 NN denotes antibody
T8804 22764-22767 VBD denotes was
T8805 22768-22777 VBN denotes confirmed
T8806 22778-22780 IN denotes by
T8807 22781-22795 NN denotes pre-incubation
T8808 22796-22798 IN denotes of
T8809 22799-22803 CD denotes IL10
T8810 22804-22808 IN denotes with
T8811 22809-22818 JJ denotes anti-IL10
T8812 22819-22827 NN denotes antibody
T8813 22828-22836 VBN denotes compared
T8814 22837-22839 TO denotes to
T8815 22840-22841 DT denotes a
T8816 22842-22845 NN denotes rat
T8817 22846-22850 JJ denotes IgG1
T8818 22851-22858 NN denotes isotype
T8819 22859-22866 NN denotes control
T8820 22867-22868 -LRB- denotes (
T8821 22868-22874 NN denotes Figure
T8822 22875-22877 NN denotes 5C
T8823 22877-22878 -RRB- denotes )
T8824 22878-22879 . denotes .
T8825 23916-23923 NNP denotes Nuclear
T8826 23924-23937 NN denotes translocation
T8827 23938-23940 IN denotes of
T8828 23941-23947 NNP denotes pStat3
T8829 23948-23950 VBZ denotes is
T8830 23951-23952 DT denotes a
T8831 23953-23964 NN denotes consequence
T8832 23965-23967 IN denotes of
T8833 23968-23978 NN denotes activation
T8834 23978-23979 , denotes ,
T8835 23980-23983 CC denotes and
T8836 23984-23991 JJ denotes nuclear
T8837 23992-23998 NN denotes pStat3
T8838 23999-24002 VBD denotes was
T8839 24003-24006 RB denotes not
T8840 24007-24015 VBN denotes detected
T8841 24016-24018 IN denotes by
T8842 24019-24039 NN denotes immunohistochemistry
T8843 24040-24048 NN denotes staining
T8844 24049-24051 IN denotes of
T8845 24052-24058 JJ denotes spleen
T8846 24059-24067 NNS denotes sections
T8847 24068-24072 IN denotes from
T8848 24073-24080 NN denotes control
T8849 24081-24085 NNS denotes mice
T8850 24085-24086 . denotes .
T8851 24087-24094 RB denotes However
T8852 24094-24095 , denotes ,
T8853 24096-24103 JJ denotes nuclear
T8854 24104-24110 NN denotes pStat3
T8855 24111-24114 VBD denotes was
T8856 24115-24125 JJ denotes detectable
T8857 24126-24128 IN denotes in
T8858 24129-24133 CD denotes LMP1
T8859 24134-24144 JJ denotes transgenic
T8860 24145-24149 NNS denotes mice
T8861 24150-24153 CC denotes and
T8862 24154-24163 JJ denotes wild-type
T8863 24164-24173 NNS denotes lymphomas
T8864 24174-24177 CC denotes and
T8865 24178-24181 VBD denotes was
T8866 24182-24190 VBN denotes detected
T8867 24191-24195 RBR denotes more
T8868 24196-24209 RB denotes homogeneously
T8869 24210-24212 IN denotes in
T8870 24213-24217 CD denotes LMP1
T8871 24218-24228 JJ denotes transgenic
T8872 24229-24238 NNS denotes lymphomas
T8873 24239-24240 -LRB- denotes (
T8874 24240-24246 NN denotes Figure
T8875 24247-24249 CD denotes 5D
T8876 24249-24250 -RRB- denotes )
T8877 24250-24251 . denotes .
T8878 24252-24255 DT denotes The
T8879 24256-24268 JJ denotes constitutive
T8880 24269-24279 NN denotes activation
T8881 24280-24282 IN denotes of
T8882 24283-24289 JJ denotes pStat3
T8883 24290-24293 CC denotes and
T8884 24294-24302 JJ denotes abundant
T8885 24303-24310 JJ denotes nuclear
T8886 24311-24316 JJ denotes Stat3
T8887 24317-24325 VBZ denotes suggests
T8888 24326-24330 IN denotes that
T8889 24331-24336 JJ denotes Stat3
T8890 24337-24346 VBG denotes signaling
T8891 24347-24358 VBZ denotes contributes
T8892 24359-24361 TO denotes to
T8893 24362-24375 JJ denotes LMP1-mediated
T8894 24376-24384 NN denotes lymphoma
T8895 24385-24396 NN denotes development
T8896 24396-24397 . denotes .
T10502 24399-24403 CD denotes LMP1
T10503 24404-24413 NNP denotes Activates
T10504 24414-24417 NNP denotes Akt
T10505 24418-24427 VBG denotes Signaling
T10506 24428-24431 CC denotes and
T10507 24432-24443 VBZ denotes Deregulates
T10508 24444-24447 DT denotes the
T10509 24448-24450 NNP denotes Rb
T10510 24451-24455 NNP denotes Cell
T10511 24456-24461 NNP denotes Cycle
T10512 24462-24469 NNP denotes Pathway
T10513 24470-24474 NNP denotes LMP1
T10514 24475-24489 NN denotes transformation
T10515 24490-24492 IN denotes of
T10516 24493-24499 NN denotes rodent
T10517 24500-24511 NNS denotes fibroblasts
T10518 24512-24520 VBZ denotes requires
T10519 24521-24531 NN denotes activation
T10520 24532-24534 IN denotes of
T10521 24535-24539 NNP denotes PI3K
T10522 24540-24543 CC denotes and
T10523 24544-24547 NNP denotes Akt
T10524 24548-24549 NNP denotes [
T10525 24549-24550 CD denotes 5
T10526 24550-24551 NNP denotes ]
T10527 24551-24552 . denotes .
T10528 24553-24565 RB denotes Additionally
T10529 24565-24566 , denotes ,
T10530 24567-24576 VBN denotes activated
T10531 24577-24581 NNP denotes pAkt
T10532 24582-24584 VBZ denotes is
T10533 24585-24595 RB denotes frequently
T10534 24596-24604 VBN denotes detected
T10535 24605-24607 IN denotes in
T10536 24608-24611 NNP denotes NPC
T10537 24612-24615 CC denotes and
T10538 24616-24619 DT denotes the
T10539 24620-24630 JJ denotes neoplastic
T10540 24631-24645 NNP denotes Reed-Sternberg
T10541 24646-24651 NNS denotes cells
T10542 24652-24654 IN denotes of
T10543 24655-24664 JJ denotes classical
T10544 24665-24667 NNP denotes HD
T10545 24668-24669 NNP denotes [
T10546 24669-24674 CD denotes 39,40
T10547 24674-24675 NNP denotes ]
T10548 24675-24676 . denotes .
T10549 24677-24679 TO denotes To
T10550 24680-24689 VB denotes determine
T10551 24690-24692 IN denotes if
T10552 24693-24696 NNP denotes Akt
T10553 24697-24706 VBG denotes signaling
T10554 24707-24709 VBZ denotes is
T10555 24710-24719 VBN denotes activated
T10556 24720-24722 IN denotes in
T10557 24723-24727 CD denotes LMP1
T10558 24728-24738 JJ denotes transgenic
T10559 24739-24743 NNS denotes mice
T10560 24743-24744 , denotes ,
T10561 24745-24749 NNP denotes pAkt
T10562 24750-24753 CC denotes and
T10563 24754-24761 JJ denotes several
T10564 24762-24764 IN denotes of
T10565 24765-24768 PRP$ denotes its
T10566 24769-24776 NNS denotes targets
T10567 24777-24781 VBD denotes were
T10568 24782-24790 VBN denotes assessed
T10569 24791-24793 IN denotes by
T10570 24794-24808 VBG denotes immunoblotting
T10571 24809-24811 IN denotes of
T10572 24812-24819 JJ denotes splenic
T10573 24820-24824 NNP denotes CD19
T10574 24824-24825 NNP denotes +
T10575 24826-24839 NNP denotes MACS-purified
T10576 24840-24841 NNP denotes B
T10577 24842-24847 NNS denotes cells
T10578 24847-24848 . denotes .
T10579 24849-24853 CD denotes LMP1
T10580 24854-24864 JJ denotes transgenic
T10581 24865-24866 NNP denotes B
T10582 24867-24872 NNS denotes cells
T10583 24873-24876 VBD denotes had
T10584 24877-24886 VBN denotes increased
T10585 24887-24893 NNS denotes levels
T10586 24894-24896 IN denotes of
T10587 24897-24901 NN denotes pAkt
T10588 24902-24910 VBN denotes compared
T10589 24911-24913 TO denotes to
T10590 24914-24923 JJ denotes wild-type
T10591 24924-24935 NNS denotes lymphocytes
T10592 24935-24936 : denotes ;
T10593 24937-24944 RB denotes however
T10594 24944-24945 , denotes ,
T10595 24946-24957 NN denotes progression
T10596 24958-24960 TO denotes to
T10597 24961-24969 NN denotes lymphoma
T10598 24970-24972 IN denotes in
T10599 24973-24977 DT denotes both
T10600 24978-24991 JJ denotes LMP1-positive
T10601 24992-24995 CC denotes and
T10602 24996-24997 : denotes -
T10603 24997-25005 JJ denotes negative
T10604 25006-25014 NN denotes lymphoma
T10605 25015-25020 NNS denotes cells
T10606 25021-25024 VBD denotes did
T10607 25025-25028 RB denotes not
T10608 25029-25036 JJ denotes further
T10609 25037-25045 NN denotes increase
T10610 25046-25050 NN denotes pAkt
T10611 25051-25057 NNS denotes levels
T10612 25057-25058 . denotes .
T10613 25059-25062 DT denotes The
T10614 25063-25066 NNP denotes Akt
T10615 25067-25073 NN denotes target
T10616 25074-25082 NN denotes glycogen
T10617 25083-25091 NN denotes synthase
T10618 25092-25098 NN denotes kinase
T10619 25099-25100 CD denotes 3
T10620 25101-25102 -LRB- denotes (
T10621 25102-25106 NN denotes GSK3
T10622 25106-25107 -RRB- denotes )
T10623 25108-25110 VBZ denotes is
T10624 25111-25122 VBN denotes inactivated
T10625 25123-25125 IN denotes by
T10626 25126-25141 NN denotes phosphorylation
T10627 25141-25142 : denotes ;
T10628 25143-25150 RB denotes however
T10629 25150-25151 , denotes ,
T10630 25152-25161 VBD denotes increased
T10631 25162-25176 VBN denotes phosphorylated
T10632 25177-25181 NNP denotes GSK3
T10633 25182-25185 VBD denotes was
T10634 25186-25189 RB denotes not
T10635 25190-25198 VBN denotes detected
T10636 25199-25201 IN denotes in
T10637 25202-25205 DT denotes the
T10638 25206-25216 JJ denotes transgenic
T10639 25217-25228 NNS denotes lymphocytes
T10640 25229-25232 CC denotes and
T10641 25233-25236 VBD denotes was
T10642 25237-25243 RB denotes almost
T10643 25244-25250 JJ denotes absent
T10644 25251-25253 IN denotes in
T10645 25254-25257 DT denotes the
T10646 25258-25266 NN denotes lymphoma
T10647 25267-25274 NNS denotes samples
T10648 25275-25276 -LRB- denotes (
T10649 25276-25282 NN denotes Figure
T10650 25283-25285 NN denotes 6A
T10651 25285-25286 -RRB- denotes )
T10652 25286-25287 . denotes .
T10653 25288-25292 DT denotes This
T10654 25293-25300 NN denotes finding
T10655 25301-25310 VBZ denotes indicates
T10656 25311-25315 IN denotes that
T10657 25316-25320 NNP denotes GSK3
T10658 25321-25323 VBZ denotes is
T10659 25324-25327 RB denotes not
T10660 25328-25329 DT denotes a
T10661 25330-25336 NN denotes target
T10662 25337-25339 IN denotes of
T10663 25340-25349 VBN denotes activated
T10664 25350-25353 NNP denotes Akt
T10665 25354-25356 IN denotes in
T10666 25357-25360 DT denotes the
T10667 25361-25365 NNP denotes LMP1
T10668 25366-25376 NN denotes transgenic
T10669 25377-25388 NNS denotes lymphocytes
T10670 25389-25392 CC denotes and
T10671 25393-25401 NN denotes lymphoma
T10672 25402-25407 NNS denotes cells
T10673 25407-25408 . denotes .
T10674 25409-25418 RB denotes Similarly
T10675 25418-25419 , denotes ,
T10676 25420-25430 NN denotes activation
T10677 25431-25433 IN denotes of
T10678 25434-25437 NNP denotes Akt
T10679 25438-25445 IN denotes without
T10680 25446-25461 NN denotes phosphorylation
T10681 25462-25464 IN denotes of
T10682 25465-25469 NNP denotes GSK3
T10683 25470-25473 VBZ denotes has
T10684 25474-25478 VBN denotes been
T10685 25479-25489 RB denotes previously
T10686 25490-25495 VBN denotes shown
T10687 25496-25498 IN denotes in
T10688 25499-25511 JJ denotes EBV-positive
T10689 25512-25514 NNP denotes HD
T10690 25515-25516 NNP denotes [
T10691 25516-25518 CD denotes 40
T10692 25518-25519 NNP denotes ]
T10693 25519-25520 . denotes .
T10694 25521-25523 IN denotes In
T10695 25524-25532 NN denotes contrast
T10696 25532-25533 , denotes ,
T10697 25534-25537 DT denotes the
T10698 25538-25547 JJ denotes wild-type
T10699 25548-25559 NNS denotes lymphocytes
T10700 25560-25566 VBD denotes lacked
T10701 25567-25576 VBN denotes activated
T10702 25577-25580 NNP denotes Akt
T10703 25581-25584 CC denotes but
T10704 25585-25588 VBD denotes did
T10705 25589-25593 VB denotes have
T10706 25594-25604 JJ denotes detectable
T10707 25605-25619 VBN denotes phosphorylated
T10708 25620-25624 NNP denotes GSK3
T10709 25624-25625 . denotes .
T10710 25626-25630 DT denotes This
T10711 25631-25638 JJ denotes further
T10712 25639-25647 VBZ denotes suggests
T10713 25648-25652 IN denotes that
T10714 25653-25663 JJ denotes additional
T10715 25664-25672 NNS denotes pathways
T10716 25673-25676 VBP denotes are
T10717 25677-25685 VBN denotes involved
T10718 25686-25688 IN denotes in
T10719 25689-25692 DT denotes the
T10720 25693-25703 NN denotes regulation
T10721 25704-25706 IN denotes of
T10722 25707-25711 NNP denotes GSK3
T10723 25711-25712 . denotes .
T10724 26382-26384 TO denotes To
T10725 26385-26393 VB denotes identify
T10726 26394-26399 JJ denotes other
T10727 26400-26409 JJ denotes potential
T10728 26410-26413 NNP denotes Akt
T10729 26414-26421 NNS denotes targets
T10730 26421-26422 , denotes ,
T10731 26423-26433 NN denotes immunoblot
T10732 26434-26442 NN denotes analysis
T10733 26443-26446 IN denotes for
T10734 26447-26453 NN denotes p-mTOR
T10735 26454-26457 VBD denotes was
T10736 26458-26467 VBN denotes performed
T10737 26467-26468 . denotes .
T10738 26469-26478 VBN denotes Activated
T10739 26479-26485 NN denotes p-mTOR
T10740 26486-26489 VBD denotes was
T10741 26490-26493 RB denotes not
T10742 26494-26503 VBN denotes increased
T10743 26504-26506 IN denotes in
T10744 26507-26511 CD denotes LMP1
T10745 26512-26522 JJ denotes transgenic
T10746 26523-26534 NNS denotes lymphocytes
T10747 26535-26537 CC denotes or
T10748 26538-26546 NN denotes lymphoma
T10749 26547-26552 NNS denotes cells
T10750 26552-26553 , denotes ,
T10751 26554-26564 VBG denotes indicating
T10752 26565-26569 IN denotes that
T10753 26570-26574 DT denotes this
T10754 26575-26582 NN denotes pathway
T10755 26583-26585 VBZ denotes is
T10756 26586-26589 RB denotes not
T10757 26590-26598 VBN denotes affected
T10758 26599-26601 IN denotes by
T10759 26602-26614 JJ denotes LMP1-induced
T10760 26615-26618 NNP denotes Akt
T10761 26619-26629 NN denotes activation
T10762 26630-26633 CC denotes and
T10763 26634-26638 VBZ denotes does
T10764 26639-26642 RB denotes not
T10765 26643-26653 VB denotes contribute
T10766 26654-26656 TO denotes to
T10767 26657-26665 VB denotes lymphoma
T10768 26666-26677 NN denotes development
T10769 26678-26679 -LRB- denotes (
T10770 26679-26685 NN denotes Figure
T10771 26686-26688 NN denotes 6B
T10772 26688-26689 -RRB- denotes )
T10773 26689-26690 . denotes .
T10774 26691-26694 NNP denotes Akt
T10775 26695-26697 VBZ denotes is
T10776 26698-26702 RB denotes also
T10777 26703-26708 VBN denotes known
T10778 26709-26711 TO denotes to
T10779 26712-26725 VB denotes phosphorylate
T10780 26726-26729 CC denotes and
T10781 26730-26736 VB denotes induce
T10782 26737-26740 DT denotes the
T10783 26741-26752 NN denotes degradation
T10784 26753-26755 IN denotes of
T10785 26756-26759 DT denotes the
T10786 26760-26773 JJ denotes pro-apoptotic
T10787 26774-26782 NNP denotes Forkhead
T10788 26783-26789 NN denotes family
T10789 26790-26792 IN denotes of
T10790 26793-26806 NN denotes transcription
T10791 26807-26814 NNS denotes factors
T10792 26814-26815 , denotes ,
T10793 26816-26823 VBG denotes leading
T10794 26824-26826 TO denotes to
T10795 26827-26831 NN denotes cell
T10796 26832-26837 NN denotes cycle
T10797 26838-26849 NN denotes progression
T10798 26850-26853 CC denotes and
T10799 26854-26862 NN denotes survival
T10800 26863-26865 IN denotes in
T10801 26866-26870 DT denotes some
T10802 26871-26876 JJ denotes human
T10803 26877-26883 NNS denotes tumors
T10804 26884-26885 NNP denotes [
T10805 26885-26890 CD denotes 41,42
T10806 26890-26891 NNP denotes ]
T10807 26891-26892 . denotes .
T10808 26893-26903 NNP denotes Immunoblot
T10809 26904-26912 NN denotes analysis
T10810 26913-26915 IN denotes of
T10811 26916-26923 JJ denotes splenic
T10812 26924-26925 NNP denotes B
T10813 26926-26931 NNS denotes cells
T10814 26932-26935 VBD denotes did
T10815 26936-26939 RB denotes not
T10816 26940-26952 RB denotes consistently
T10817 26953-26959 VB denotes detect
T10818 26960-26967 JJ denotes p-FoxO1
T10819 26968-26974 NNS denotes levels
T10820 26974-26975 , denotes ,
T10821 26976-26977 DT denotes a
T10822 26978-26984 NN denotes signal
T10823 26985-26989 WDT denotes that
T10824 26990-26997 VBZ denotes targets
T10825 26998-27003 NNP denotes FoxO1
T10826 27004-27007 IN denotes for
T10827 27008-27019 NN denotes degradation
T10828 27019-27020 . denotes .
T10829 27021-27026 RB denotes Hence
T10830 27026-27027 , denotes ,
T10831 27028-27039 NN denotes degradation
T10832 27040-27042 IN denotes of
T10833 27043-27048 NNP denotes FoxO1
T10834 27049-27052 VBD denotes was
T10835 27053-27061 VBN denotes assessed
T10836 27062-27064 IN denotes by
T10837 27065-27074 NN denotes detection
T10838 27075-27077 IN denotes of
T10839 27078-27083 JJ denotes total
T10840 27084-27089 JJ denotes FoxO1
T10841 27090-27096 NNS denotes levels
T10842 27096-27097 . denotes .
T10843 27098-27108 NNP denotes Immunoblot
T10844 27109-27117 NN denotes analysis
T10845 27118-27127 VBD denotes indicated
T10846 27128-27132 IN denotes that
T10847 27133-27138 JJ denotes total
T10848 27139-27144 JJ denotes FoxO1
T10849 27145-27151 NNS denotes levels
T10850 27152-27156 VBD denotes were
T10851 27157-27164 RB denotes greatly
T10852 27165-27174 VBN denotes decreased
T10853 27175-27177 IN denotes in
T10854 27178-27187 JJ denotes wild-type
T10855 27188-27191 CC denotes and
T10856 27192-27196 JJ denotes LMP1
T10857 27197-27207 JJ denotes transgenic
T10858 27208-27217 NNS denotes lymphomas
T10859 27218-27219 -LRB- denotes (
T10860 27219-27225 NN denotes Figure
T10861 27226-27228 NN denotes 6B
T10862 27228-27229 -RRB- denotes )
T10863 27229-27230 , denotes ,
T10864 27231-27241 VBG denotes suggesting
T10865 27242-27246 IN denotes that
T10866 27247-27257 NN denotes inhibition
T10867 27258-27260 IN denotes of
T10868 27261-27264 DT denotes the
T10869 27265-27273 NNP denotes Forkhead
T10870 27274-27283 VBG denotes signaling
T10871 27284-27291 NN denotes pathway
T10872 27292-27294 VBZ denotes is
T10873 27295-27297 DT denotes an
T10874 27298-27307 JJ denotes important
T10875 27308-27314 NN denotes target
T10876 27315-27317 IN denotes of
T10877 27318-27321 NNP denotes Akt
T10878 27322-27324 IN denotes in
T10879 27325-27333 NN denotes lymphoma
T10880 27334-27345 NN denotes development
T10881 27345-27346 . denotes .
T10882 27347-27354 RB denotes However
T10883 27354-27355 , denotes ,
T10884 27356-27367 VBG denotes considering
T10885 27368-27372 IN denotes that
T10886 27373-27376 NNP denotes Akt
T10887 27377-27387 NN denotes activation
T10888 27388-27391 VBD denotes did
T10889 27392-27395 RB denotes not
T10890 27396-27402 VB denotes induce
T10891 27403-27408 JJ denotes FoxO1
T10892 27409-27420 NN denotes degradation
T10893 27421-27423 IN denotes in
T10894 27424-27428 CD denotes LMP1
T10895 27429-27439 JJ denotes transgenic
T10896 27440-27441 NNP denotes B
T10897 27442-27447 NNS denotes cells
T10898 27447-27448 , denotes ,
T10899 27449-27452 NNP denotes Akt
T10900 27453-27456 MD denotes may
T10901 27457-27460 RB denotes not
T10902 27461-27463 VB denotes be
T10903 27464-27467 DT denotes the
T10904 27468-27472 JJ denotes sole
T10905 27473-27482 NN denotes regulator
T10906 27483-27485 IN denotes of
T10907 27486-27491 NNP denotes FoxO1
T10908 27491-27492 , denotes ,
T10909 27493-27496 CC denotes and
T10910 27497-27499 PRP denotes it
T10911 27500-27503 MD denotes may
T10912 27504-27506 VB denotes be
T10913 27507-27511 IN denotes that
T10914 27512-27523 NN denotes progression
T10915 27524-27526 TO denotes to
T10916 27527-27535 NN denotes lymphoma
T10917 27536-27544 VBZ denotes requires
T10918 27545-27555 NN denotes modulation
T10919 27556-27558 IN denotes of
T10920 27559-27567 JJ denotes multiple
T10921 27568-27576 NNS denotes pathways
T10922 27576-27577 . denotes .
T10923 27578-27581 DT denotes The
T10924 27582-27590 NNP denotes Forkhead
T10925 27591-27597 NN denotes family
T10926 27598-27600 IN denotes of
T10927 27601-27614 NN denotes transcription
T10928 27615-27622 NNS denotes factors
T10929 27623-27625 VBZ denotes is
T10930 27626-27631 VBN denotes known
T10931 27632-27634 TO denotes to
T10932 27635-27641 VB denotes induce
T10933 27642-27645 DT denotes the
T10934 27646-27656 NN denotes expression
T10935 27657-27659 IN denotes of
T10936 27660-27663 DT denotes the
T10937 27664-27667 NNP denotes Cdk
T10938 27668-27677 NN denotes inhibitor
T10939 27678-27681 CD denotes p27
T10940 27682-27683 NNP denotes [
T10941 27683-27688 CD denotes 43,44
T10942 27688-27689 NNP denotes ]
T10943 27689-27690 . denotes .
T10944 27691-27707 JJ denotes LMP1-transformed
T10945 27708-27714 NN denotes rodent
T10946 27715-27726 NNS denotes fibroblasts
T10947 27727-27731 VBP denotes have
T10948 27732-27741 VBN denotes decreased
T10949 27742-27752 NN denotes expression
T10950 27753-27755 IN denotes of
T10951 27756-27759 CD denotes p27
T10952 27759-27760 , denotes ,
T10953 27761-27773 NN denotes upregulation
T10954 27774-27776 IN denotes of
T10955 27777-27781 NNP denotes Cdk2
T10956 27781-27782 , denotes ,
T10957 27783-27786 CC denotes and
T10958 27787-27797 JJ denotes subsequent
T10959 27798-27813 NN denotes phosphorylation
T10960 27814-27817 CC denotes and
T10961 27818-27830 NN denotes inactivation
T10962 27831-27833 IN denotes of
T10963 27834-27837 DT denotes the
T10964 27838-27843 NN denotes tumor
T10965 27844-27854 NN denotes suppressor
T10966 27855-27859 NN denotes gene
T10967 27860-27862 NNP denotes Rb
T10968 27863-27864 NNP denotes [
T10969 27864-27866 CD denotes 45
T10970 27866-27867 NNP denotes ]
T10971 27867-27868 . denotes .
T10972 27869-27871 TO denotes To
T10973 27872-27883 VB denotes investigate
T10974 27884-27891 IN denotes whether
T10975 27892-27896 NNP denotes LMP1
T10976 27897-27905 VBD denotes affected
T10977 27906-27910 NN denotes cell
T10978 27911-27916 NN denotes cycle
T10979 27917-27927 NN denotes regulation
T10980 27928-27935 IN denotes through
T10981 27936-27939 DT denotes the
T10982 27940-27942 NNP denotes Rb
T10983 27943-27950 NN denotes pathway
T10984 27951-27953 IN denotes in
T10985 27954-27955 NNP denotes B
T10986 27956-27961 NNS denotes cells
T10987 27961-27962 , denotes ,
T10988 27963-27973 NN denotes immunoblot
T10989 27974-27982 NNS denotes analyses
T10990 27983-27986 IN denotes for
T10991 27987-27990 NNP denotes pRb
T10992 27990-27991 , denotes ,
T10993 27992-27996 NNP denotes Cdk2
T10994 27996-27997 , denotes ,
T10995 27998-28001 CC denotes and
T10996 28002-28005 CD denotes p27
T10997 28006-28010 VBD denotes were
T10998 28011-28020 VBN denotes performed
T10999 28021-28023 IN denotes on
T11000 28024-28031 JJ denotes splenic
T11001 28032-28036 NNP denotes CD19
T11002 28036-28037 NNP denotes +
T11003 28038-28051 NNP denotes MACS-purified
T11004 28052-28053 NNP denotes B
T11005 28054-28059 NNS denotes cells
T11006 28059-28060 . denotes .
T11007 28061-28065 CD denotes LMP1
T11008 28066-28076 JJ denotes transgenic
T11009 28077-28078 NNP denotes B
T11010 28079-28084 NNS denotes cells
T11011 28085-28088 VBD denotes had
T11012 28089-28097 VBN denotes enhanced
T11013 28098-28104 NNS denotes levels
T11014 28105-28107 IN denotes of
T11015 28108-28111 NN denotes pRb
T11016 28112-28116 IN denotes with
T11017 28117-28128 JJ denotes concomitant
T11018 28129-28142 NN denotes stabilization
T11019 28143-28145 IN denotes of
T11020 28146-28151 JJ denotes total
T11021 28152-28154 NN denotes Rb
T11022 28155-28161 NNS denotes levels
T11023 28162-28165 CC denotes and
T11024 28166-28170 JJ denotes Cdk2
T11025 28171-28179 VBN denotes compared
T11026 28180-28182 TO denotes to
T11027 28183-28192 JJ denotes wild-type
T11028 28193-28194 NNP denotes B
T11029 28195-28206 NNS denotes lymphocytes
T11030 28207-28208 -LRB- denotes (
T11031 28208-28214 NN denotes Figure
T11032 28215-28217 NN denotes 6C
T11033 28217-28218 -RRB- denotes )
T11034 28218-28219 . denotes .
T11035 28220-28231 NNP denotes Progression
T11036 28232-28234 TO denotes to
T11037 28235-28243 VB denotes lymphoma
T11038 28244-28246 IN denotes in
T11039 28247-28251 DT denotes both
T11040 28252-28261 JJ denotes wild-type
T11041 28262-28265 CC denotes and
T11042 28266-28270 JJ denotes LMP1
T11043 28271-28281 JJ denotes transgenic
T11044 28282-28290 NN denotes lymphoma
T11045 28291-28296 NNS denotes cells
T11046 28297-28300 VBD denotes led
T11047 28301-28303 TO denotes to
T11048 28304-28313 VBN denotes increased
T11049 28314-28320 NNS denotes levels
T11050 28321-28323 IN denotes of
T11051 28324-28326 NNP denotes Rb
T11052 28326-28327 , denotes ,
T11053 28328-28343 RB denotes correspondingly
T11054 28344-28348 JJ denotes high
T11055 28349-28355 NNS denotes levels
T11056 28356-28358 IN denotes of
T11057 28359-28363 NNP denotes Cdk2
T11058 28363-28364 , denotes ,
T11059 28365-28368 CC denotes and
T11060 28369-28378 VBD denotes decreased
T11061 28379-28385 NNS denotes levels
T11062 28386-28388 IN denotes of
T11063 28389-28392 CD denotes p27
T11064 28393-28394 -LRB- denotes (
T11065 28394-28400 NN denotes Figure
T11066 28401-28403 NN denotes 6C
T11067 28403-28404 -RRB- denotes )
T11068 28404-28405 . denotes .
T11069 28406-28411 DT denotes These
T11070 28412-28416 NNS denotes data
T11071 28417-28425 VBP denotes indicate
T11072 28426-28430 IN denotes that
T11073 28431-28434 DT denotes the
T11074 28435-28437 NNP denotes Rb
T11075 28438-28445 NN denotes pathway
T11076 28446-28448 VBZ denotes is
T11077 28449-28460 VBN denotes deregulated
T11078 28461-28463 IN denotes in
T11079 28464-28468 CD denotes LMP1
T11080 28469-28479 JJ denotes transgenic
T11081 28480-28491 NNS denotes lymphocytes
T11082 28492-28495 CC denotes and
T11083 28496-28500 IN denotes that
T11084 28501-28509 NN denotes lymphoma
T11085 28510-28515 NNS denotes cells
T11086 28516-28519 VBP denotes are
T11087 28520-28533 VBN denotes distinguished
T11088 28534-28536 IN denotes by
T11089 28537-28541 NN denotes loss
T11090 28542-28544 IN denotes of
T11091 28545-28550 NNP denotes FoxO1
T11092 28551-28554 CC denotes and
T11093 28555-28564 VBD denotes decreased
T11094 28565-28568 CD denotes p27
T11095 28568-28569 . denotes .
T12763 28571-28575 CD denotes LMP1
T12764 28576-28584 NNP denotes Promotes
T12765 28585-28590 NNP denotes Tumor
T12766 28591-28597 NNP denotes Growth
T12767 28598-28601 CC denotes and
T12768 28602-28610 NNP denotes Survival
T12769 28611-28618 IN denotes through
T12770 28619-28629 NNP denotes Activation
T12771 28630-28632 IN denotes of
T12772 28633-28636 NNP denotes Akt
T12773 28636-28637 , denotes ,
T12774 28638-28642 NNP denotes NFκB
T12775 28642-28643 , denotes ,
T12776 28644-28647 CC denotes and
T12777 28648-28653 NNP denotes Stat3
T12778 28654-28662 NNPS denotes Pathways
T12779 28663-28665 TO denotes To
T12780 28666-28673 VB denotes explore
T12781 28674-28679 WDT denotes which
T12782 28680-28688 NNS denotes pathways
T12783 28689-28693 VBD denotes were
T12784 28694-28702 VBN denotes required
T12785 28703-28706 IN denotes for
T12786 28707-28710 DT denotes the
T12787 28711-28719 JJ denotes enhanced
T12788 28720-28726 NN denotes growth
T12789 28727-28730 CC denotes and
T12790 28731-28739 NN denotes survival
T12791 28740-28742 IN denotes of
T12792 28743-28755 JJ denotes LMP1-induced
T12793 28756-28765 NNS denotes lymphomas
T12794 28765-28766 , denotes ,
T12795 28767-28778 NNS denotes splenocytes
T12796 28779-28783 IN denotes from
T12797 28784-28793 JJ denotes wild-type
T12798 28794-28797 CC denotes and
T12799 28798-28802 JJ denotes LMP1
T12800 28803-28813 JJ denotes transgenic
T12801 28814-28818 NNS denotes mice
T12802 28819-28823 VBD denotes were
T12803 28824-28832 VBN denotes cultured
T12804 28833-28835 IN denotes in
T12805 28836-28839 DT denotes the
T12806 28840-28848 NN denotes presence
T12807 28849-28851 IN denotes of
T12808 28852-28862 NNS denotes inhibitors
T12809 28863-28866 IN denotes for
T12810 28867-28870 NNP denotes Akt
T12811 28870-28871 , denotes ,
T12812 28872-28876 NNP denotes NFκB
T12813 28876-28877 , denotes ,
T12814 28878-28883 NNP denotes Stat3
T12815 28883-28884 , denotes ,
T12816 28885-28889 NNP denotes mTOR
T12817 28889-28890 , denotes ,
T12818 28891-28893 CC denotes or
T12819 28894-28898 NNP denotes MAPK
T12820 28899-28902 CC denotes and
T12821 28903-28910 VBN denotes assayed
T12822 28911-28914 IN denotes for
T12823 28915-28921 NN denotes growth
T12824 28922-28925 CC denotes and
T12825 28926-28934 NN denotes survival
T12826 28935-28937 IN denotes by
T12827 28938-28941 DT denotes the
T12828 28942-28945 NNP denotes MTS
T12829 28946-28951 NN denotes assay
T12830 28951-28952 . denotes .
T12831 28953-28955 IN denotes As
T12832 28956-28966 RB denotes previously
T12833 28967-28972 VBN denotes shown
T12834 28972-28973 , denotes ,
T12835 28974-28983 JJ denotes wild-type
T12836 28984-28995 NNS denotes lymphocytes
T12837 28996-29000 VBD denotes were
T12838 29001-29004 RB denotes not
T12839 29005-29011 JJ denotes viable
T12840 29012-29014 IN denotes in
T12841 29015-29022 NN denotes culture
T12842 29023-29026 CC denotes and
T12843 29027-29032 MD denotes could
T12844 29033-29036 RB denotes not
T12845 29037-29039 VB denotes be
T12846 29040-29046 VBN denotes tested
T12847 29047-29051 IN denotes with
T12848 29052-29055 DT denotes the
T12849 29056-29066 NNS denotes inhibitors
T12850 29066-29067 . denotes .
T12851 29068-29075 RB denotes However
T12852 29075-29076 , denotes ,
T12853 29077-29080 DT denotes the
T12854 29081-29089 JJ denotes enhanced
T12855 29090-29099 NN denotes viability
T12856 29100-29102 IN denotes of
T12857 29103-29107 CD denotes LMP1
T12858 29108-29118 JJ denotes transgenic
T12859 29119-29130 NNS denotes lymphocytes
T12860 29131-29134 VBD denotes was
T12861 29135-29146 RB denotes effectively
T12862 29147-29154 VBN denotes blocked
T12863 29155-29157 IN denotes by
T12864 29158-29167 NN denotes treatment
T12865 29168-29172 IN denotes with
T12866 29173-29184 NN denotes triciribine
T12867 29184-29185 , denotes ,
T12868 29186-29191 NNP denotes BAY11
T12869 29192-29196 CD denotes 7085
T12870 29196-29197 , denotes ,
T12871 29198-29210 NN denotes cucurbitacin
T12872 29211-29212 PRP denotes I
T12873 29212-29213 , denotes ,
T12874 29214-29217 CC denotes and
T12875 29218-29226 RB denotes slightly
T12876 29227-29231 IN denotes with
T12877 29232-29240 CD denotes SB203580
T12878 29240-29241 , denotes ,
T12879 29242-29245 CC denotes but
T12880 29246-29249 RB denotes not
T12881 29250-29252 IN denotes by
T12882 29253-29262 NN denotes treatment
T12883 29263-29267 IN denotes with
T12884 29268-29277 NN denotes rapamycin
T12885 29277-29278 , denotes ,
T12886 29279-29284 NNP denotes U0126
T12887 29284-29285 , denotes ,
T12888 29286-29288 CC denotes or
T12889 29289-29294 NNP denotes AG490
T12890 29295-29296 -LRB- denotes (
T12891 29296-29302 NNP denotes Figure
T12892 29303-29304 CD denotes 7
T12893 29304-29305 -RRB- denotes )
T12894 29305-29306 . denotes .
T12895 29307-29318 NNP denotes Triciribine
T12896 29319-29327 VBZ denotes inhibits
T12897 29328-29331 DT denotes the
T12898 29332-29342 NN denotes activation
T12899 29343-29345 IN denotes of
T12900 29346-29349 NNP denotes Akt
T12901 29350-29353 CC denotes and
T12902 29354-29356 IN denotes at
T12903 29357-29359 CD denotes 20
T12904 29360-29362 NN denotes μM
T12905 29363-29366 VBZ denotes has
T12906 29367-29371 VBN denotes been
T12907 29372-29377 VBN denotes shown
T12908 29378-29380 TO denotes to
T12909 29381-29387 VB denotes induce
T12910 29388-29394 NN denotes growth
T12911 29395-29401 NN denotes arrest
T12912 29402-29404 IN denotes in
T12913 29405-29411 NN denotes cancer
T12914 29412-29417 NNS denotes cells
T12915 29418-29422 IN denotes with
T12916 29423-29431 JJ denotes aberrant
T12917 29432-29435 NNP denotes Akt
T12918 29436-29444 NN denotes activity
T12919 29445-29446 NNP denotes [
T12920 29446-29448 CD denotes 46
T12921 29448-29449 NNP denotes ]
T12922 29449-29450 . denotes .
T12923 29451-29454 DT denotes The
T12924 29455-29462 NNS denotes effects
T12925 29463-29465 IN denotes of
T12926 29466-29477 NN denotes triciribine
T12927 29478-29480 IN denotes on
T12928 29481-29485 NN denotes cell
T12929 29486-29492 NN denotes growth
T12930 29493-29495 IN denotes of
T12931 29496-29499 DT denotes the
T12932 29500-29510 JJ denotes transgenic
T12933 29511-29522 NNS denotes lymphocytes
T12934 29523-29526 CC denotes and
T12935 29527-29536 NNS denotes lymphomas
T12936 29537-29541 VBD denotes were
T12937 29542-29550 JJ denotes apparent
T12938 29551-29553 RB denotes as
T12939 29554-29557 JJ denotes low
T12940 29558-29560 IN denotes as
T12941 29561-29562 CD denotes 1
T12942 29563-29565 NNP denotes μM
T12943 29565-29566 , denotes ,
T12944 29567-29577 VBG denotes suggesting
T12945 29578-29582 IN denotes that
T12946 29583-29593 NN denotes activation
T12947 29594-29596 IN denotes of
T12948 29597-29600 NNP denotes Akt
T12949 29601-29603 VBZ denotes is
T12950 29604-29612 VBN denotes required
T12951 29613-29616 IN denotes for
T12952 29617-29620 DT denotes the
T12953 29621-29629 NN denotes survival
T12954 29630-29633 CC denotes and
T12955 29634-29640 NN denotes growth
T12956 29641-29643 IN denotes of
T12957 29644-29648 CD denotes LMP1
T12958 29649-29659 JJ denotes transgenic
T12959 29660-29671 NNS denotes lymphocytes
T12960 29672-29675 CC denotes and
T12961 29676-29684 NN denotes lymphoma
T12962 29685-29690 NNS denotes cells
T12963 29691-29692 -LRB- denotes (
T12964 29692-29698 NN denotes Figure
T12965 29699-29700 CD denotes 7
T12966 29700-29701 -RRB- denotes )
T12967 29701-29702 . denotes .
T12968 29703-29706 DT denotes The
T12969 29707-29714 NNS denotes effects
T12970 29715-29717 IN denotes of
T12971 29718-29721 DT denotes the
T12972 29722-29732 NNS denotes inhibitors
T12973 29733-29737 VBD denotes were
T12974 29738-29746 VBN denotes assessed
T12975 29747-29749 IN denotes by
T12976 29750-29761 VBG denotes identifying
T12977 29762-29776 VBN denotes phosphorylated
T12978 29777-29780 NNP denotes Akt
T12979 29780-29781 , denotes ,
T12980 29782-29787 NNP denotes Stat3
T12981 29787-29788 , denotes ,
T12982 29789-29792 CC denotes and
T12983 29793-29798 JJ denotes total
T12984 29799-29805 NNS denotes levels
T12985 29806-29808 IN denotes of
T12986 29809-29813 NNP denotes IκBα
T12987 29814-29815 -LRB- denotes (
T12988 29815-29821 NNP denotes Figure
T12989 29822-29823 CD denotes 8
T12990 29823-29824 -RRB- denotes )
T12991 29824-29825 . denotes .
T12992 29826-29835 NNP denotes Treatment
T12993 29836-29840 IN denotes with
T12994 29841-29852 JJ denotes triciribine
T12995 29853-29864 RB denotes effectively
T12996 29865-29872 VBN denotes blocked
T12997 29873-29888 NN denotes phosphorylation
T12998 29889-29891 IN denotes of
T12999 29892-29895 NNP denotes Akt
T13000 29895-29896 , denotes ,
T13001 29897-29900 CC denotes and
T13002 29901-29915 VBD denotes phosphorylated
T13003 29916-29919 NNP denotes Akt
T13004 29920-29923 VBD denotes was
T13005 29924-29926 RB denotes no
T13006 29927-29933 RB denotes longer
T13007 29934-29942 VBN denotes detected
T13008 29943-29947 JJ denotes past
T13009 29948-29949 CD denotes 5
T13010 29950-29952 NN denotes μM
T13011 29952-29953 . denotes .
T13012 29954-29968 NNP denotes Phosphorylated
T13013 29969-29974 NNP denotes Stat3
T13014 29975-29978 CC denotes and
T13015 29979-29983 NNP denotes IκBα
T13016 29984-29988 VBD denotes were
T13017 29989-29994 RB denotes still
T13018 29995-30002 JJ denotes present
T13019 30003-30005 IN denotes at
T13020 30006-30008 CD denotes 25
T13021 30009-30011 NN denotes μM
T13022 30011-30012 . denotes .
T13023 30013-30018 DT denotes These
T13024 30019-30027 NNS denotes findings
T13025 30028-30035 VBP denotes suggest
T13026 30036-30040 IN denotes that
T13027 30041-30052 JJ denotes triciribine
T13028 30053-30065 RB denotes specifically
T13029 30066-30073 VBZ denotes targets
T13030 30074-30077 NNP denotes Akt
T13031 30078-30081 CC denotes and
T13032 30082-30086 IN denotes that
T13033 30087-30090 NNP denotes Akt
T13034 30091-30101 NN denotes activation
T13035 30102-30104 VBZ denotes is
T13036 30105-30113 VBN denotes required
T13037 30114-30117 IN denotes for
T13038 30118-30121 DT denotes the
T13039 30122-30130 JJ denotes enhanced
T13040 30131-30140 NN denotes viability
T13041 30141-30143 IN denotes of
T13042 30144-30147 DT denotes the
T13043 30148-30158 JJ denotes transgenic
T13044 30159-30170 NNS denotes lymphocytes
T13045 30171-30174 CC denotes and
T13046 30175-30183 NN denotes lymphoma
T13047 30184-30189 NNS denotes cells
T13048 30189-30190 . denotes .
T13049 31411-31421 NNP denotes Inhibition
T13050 31422-31424 IN denotes of
T13051 31425-31429 NNP denotes NFκB
T13052 31430-31439 VBG denotes signaling
T13053 31440-31447 RB denotes rapidly
T13054 31448-31455 VBZ denotes induces
T13055 31456-31460 NN denotes cell
T13056 31461-31466 NN denotes death
T13057 31467-31469 IN denotes of
T13058 31470-31485 JJ denotes EBV-transformed
T13059 31486-31497 NNS denotes lymphocytes
T13060 31498-31499 NNP denotes [
T13061 31499-31504 CD denotes 17,18
T13062 31504-31505 NNP denotes ]
T13063 31505-31506 . denotes .
T13064 31507-31512 CD denotes BAY11
T13065 31513-31517 CD denotes 7085
T13066 31517-31518 , denotes ,
T13067 31519-31521 DT denotes an
T13068 31522-31531 NN denotes inhibitor
T13069 31532-31534 IN denotes of
T13070 31535-31539 NNP denotes NFκB
T13071 31540-31549 VBG denotes signaling
T13072 31549-31550 , denotes ,
T13073 31551-31555 RB denotes also
T13074 31556-31563 RB denotes greatly
T13075 31564-31573 VBD denotes decreased
T13076 31574-31577 DT denotes the
T13077 31578-31587 NN denotes viability
T13078 31588-31590 IN denotes of
T13079 31591-31594 DT denotes the
T13080 31595-31599 NNP denotes LMP1
T13081 31600-31610 NN denotes transgenic
T13082 31611-31622 NNS denotes lymphocytes
T13083 31623-31626 CC denotes and
T13084 31627-31635 NN denotes lymphoma
T13085 31636-31641 NNS denotes cells
T13086 31642-31644 IN denotes at
T13087 31645-31650 NNS denotes doses
T13088 31651-31653 RB denotes as
T13089 31654-31657 JJ denotes low
T13090 31658-31660 IN denotes as
T13091 31661-31662 CD denotes 1
T13092 31663-31665 NNP denotes μM
T13093 31665-31666 , denotes ,
T13094 31667-31670 CC denotes and
T13095 31671-31673 IN denotes at
T13096 31674-31675 CD denotes 5
T13097 31676-31678 NNP denotes μM
T13098 31679-31682 DT denotes the
T13099 31683-31688 NNS denotes cells
T13100 31689-31693 VBD denotes were
T13101 31694-31704 RB denotes completely
T13102 31705-31714 JJ denotes nonviable
T13103 31715-31716 -LRB- denotes (
T13104 31716-31722 NN denotes Figure
T13105 31723-31724 CD denotes 7
T13106 31724-31725 -RRB- denotes )
T13107 31725-31726 . denotes .
T13108 31727-31731 DT denotes This
T13109 31732-31734 VBZ denotes is
T13110 31735-31739 RB denotes well
T13111 31740-31746 IN denotes within
T13112 31747-31750 DT denotes the
T13113 31751-31759 VBN denotes reported
T13114 31760-31764 NNP denotes IC50
T13115 31765-31767 IN denotes of
T13116 31768-31770 CD denotes 10
T13117 31771-31773 NN denotes μM
T13118 31773-31774 . denotes .
T13119 31775-31789 NNP denotes Phosphorylated
T13120 31790-31793 NNP denotes Akt
T13121 31793-31794 , denotes ,
T13122 31795-31800 NNP denotes Stat3
T13123 31800-31801 , denotes ,
T13124 31802-31805 CC denotes and
T13125 31806-31811 JJ denotes total
T13126 31812-31816 NNP denotes IκBα
T13127 31817-31821 VBD denotes were
T13128 31822-31827 RB denotes still
T13129 31828-31835 JJ denotes present
T13130 31836-31838 IN denotes up
T13131 31839-31841 TO denotes to
T13132 31842-31851 NN denotes treatment
T13133 31852-31856 IN denotes with
T13134 31857-31859 CD denotes 15
T13135 31860-31862 NN denotes μM
T13136 31863-31866 CC denotes and
T13137 31867-31871 RB denotes then
T13138 31872-31876 VBD denotes were
T13139 31877-31879 RB denotes no
T13140 31880-31886 RB denotes longer
T13141 31887-31895 VBN denotes detected
T13142 31896-31897 -LRB- denotes (
T13143 31897-31903 NN denotes Figure
T13144 31904-31905 CD denotes 8
T13145 31905-31906 -RRB- denotes )
T13146 31906-31907 . denotes .
T13147 31908-31912 DT denotes This
T13148 31913-31920 NN denotes finding
T13149 31921-31929 VBZ denotes suggests
T13150 31930-31934 IN denotes that
T13151 31935-31945 NN denotes inhibition
T13152 31946-31948 IN denotes of
T13153 31949-31953 NNP denotes NFκB
T13154 31954-31957 MD denotes can
T13155 31958-31964 VB denotes induce
T13156 31965-31969 NN denotes cell
T13157 31970-31975 NN denotes death
T13158 31976-31978 IN denotes in
T13159 31979-31983 CD denotes LMP1
T13160 31984-31994 JJ denotes transgenic
T13161 31995-32006 NNS denotes lymphocytes
T13162 32007-32010 CC denotes and
T13163 32011-32019 NN denotes lymphoma
T13164 32020-32025 NNS denotes cells
T13165 32026-32033 IN denotes without
T13166 32034-32045 JJ denotes significant
T13167 32046-32053 NNS denotes effects
T13168 32054-32056 IN denotes on
T13169 32057-32067 NN denotes activation
T13170 32068-32070 IN denotes of
T13171 32071-32074 NNP denotes Akt
T13172 32075-32077 CC denotes or
T13173 32078-32083 NNP denotes Stat3
T13174 32083-32084 . denotes .
T13175 32085-32097 NNP denotes Cucurbitacin
T13176 32098-32099 PRP denotes I
T13177 32100-32108 VBZ denotes inhibits
T13178 32109-32119 NN denotes activation
T13179 32120-32122 IN denotes of
T13180 32123-32128 JJ denotes Stat3
T13181 32129-32131 IN denotes by
T13182 32132-32143 VBG denotes suppressing
T13183 32144-32147 DT denotes the
T13184 32148-32158 NN denotes activation
T13185 32159-32161 IN denotes of
T13186 32162-32165 PRP$ denotes its
T13187 32166-32172 NN denotes kinase
T13188 32173-32177 NN denotes JAK2
T13189 32177-32178 . denotes .
T13190 32179-32181 PRP denotes It
T13191 32182-32185 VBZ denotes has
T13192 32186-32190 VBN denotes been
T13193 32191-32196 VBN denotes shown
T13194 32197-32199 TO denotes to
T13195 32200-32211 RB denotes selectively
T13196 32212-32219 VB denotes inhibit
T13197 32220-32223 DT denotes the
T13198 32224-32230 NN denotes growth
T13199 32231-32233 IN denotes of
T13200 32234-32240 NNS denotes tumors
T13201 32241-32245 IN denotes with
T13202 32246-32260 RB denotes constitutively
T13203 32261-32270 VBN denotes activated
T13204 32271-32276 NNP denotes Stat3
T13205 32277-32278 NNP denotes [
T13206 32278-32280 CD denotes 47
T13207 32280-32281 NNP denotes ]
T13208 32281-32282 . denotes .
T13209 32283-32292 RB denotes Similarly
T13210 32292-32293 , denotes ,
T13211 32294-32298 NNP denotes LMP1
T13212 32299-32309 JJ denotes transgenic
T13213 32310-32321 NNS denotes lymphocytes
T13214 32322-32325 CC denotes and
T13215 32326-32334 NN denotes lymphoma
T13216 32335-32340 NNS denotes cells
T13217 32341-32345 VBD denotes were
T13218 32346-32357 JJ denotes susceptible
T13219 32358-32360 TO denotes to
T13220 32361-32373 VB denotes cucurbitacin
T13221 32374-32375 PRP denotes I
T13222 32376-32385 NN denotes treatment
T13223 32386-32394 VBG denotes starting
T13224 32395-32397 IN denotes at
T13225 32398-32401 CD denotes 0.1
T13226 32402-32404 NNP denotes μM
T13227 32404-32405 , denotes ,
T13228 32406-32407 DT denotes a
T13229 32408-32412 NN denotes dose
T13230 32413-32417 WDT denotes that
T13231 32418-32429 VBZ denotes corresponds
T13232 32430-32437 RB denotes closely
T13233 32438-32440 TO denotes to
T13234 32441-32444 DT denotes the
T13235 32445-32453 VBN denotes reported
T13236 32454-32458 NNP denotes IC50
T13237 32459-32461 IN denotes of
T13238 32462-32465 CD denotes 500
T13239 32466-32468 NNP denotes nM
T13240 32469-32470 -LRB- denotes (
T13241 32470-32476 NNP denotes Figure
T13242 32477-32478 CD denotes 7
T13243 32478-32479 -RRB- denotes )
T13244 32480-32481 NNP denotes [
T13245 32481-32483 CD denotes 47
T13246 32483-32484 NNP denotes ]
T13247 32484-32485 . denotes .
T13248 32486-32500 NNP denotes Phosphorylated
T13249 32501-32504 NNP denotes Akt
T13250 32504-32505 , denotes ,
T13251 32506-32511 NNP denotes Stat3
T13252 32511-32512 , denotes ,
T13253 32513-32516 CC denotes and
T13254 32517-32522 JJ denotes total
T13255 32523-32527 NNP denotes IκBα
T13256 32528-32532 VBD denotes were
T13257 32533-32536 RB denotes not
T13258 32537-32547 JJ denotes detectable
T13259 32548-32552 IN denotes past
T13260 32553-32554 CD denotes 1
T13261 32555-32557 NNP denotes μM
T13262 32558-32561 CC denotes and
T13263 32562-32564 IN denotes at
T13264 32565-32571 JJR denotes higher
T13265 32572-32577 NNS denotes doses
T13266 32578-32581 DT denotes all
T13267 32582-32589 NN denotes protein
T13268 32590-32596 NNS denotes levels
T13269 32597-32601 VBD denotes were
T13270 32602-32609 RB denotes greatly
T13271 32610-32619 VBN denotes decreased
T13272 32619-32620 , denotes ,
T13273 32621-32631 JJ denotes indicative
T13274 32632-32634 IN denotes of
T13275 32635-32638 DT denotes the
T13276 32639-32644 JJ denotes total
T13277 32645-32649 NN denotes loss
T13278 32650-32652 IN denotes of
T13279 32653-32662 NN denotes viability
T13280 32663-32664 -LRB- denotes (
T13281 32664-32670 NN denotes Figure
T13282 32671-32672 CD denotes 8
T13283 32672-32673 -RRB- denotes )
T13284 32673-32674 . denotes .
T13285 32675-32676 DT denotes A
T13286 32677-32683 NN denotes second
T13287 32684-32692 VBD denotes reported
T13288 32693-32702 NN denotes inhibitor
T13289 32703-32705 IN denotes of
T13290 32706-32711 NNP denotes Stat3
T13291 32711-32712 , denotes ,
T13292 32713-32718 NNP denotes AG490
T13293 32718-32719 , denotes ,
T13294 32720-32723 VBD denotes had
T13295 32724-32726 DT denotes no
T13296 32727-32733 NN denotes effect
T13297 32734-32736 IN denotes on
T13298 32737-32743 NN denotes growth
T13299 32744-32745 -LRB- denotes (
T13300 32745-32751 NN denotes Figure
T13301 32752-32753 CD denotes 7
T13302 32753-32754 -RRB- denotes )
T13303 32754-32755 , denotes ,
T13304 32756-32759 CC denotes but
T13305 32760-32770 NN denotes activation
T13306 32771-32773 IN denotes of
T13307 32774-32777 NNP denotes Akt
T13308 32777-32778 , denotes ,
T13309 32779-32784 NNP denotes Stat3
T13310 32784-32785 , denotes ,
T13311 32786-32788 CC denotes or
T13312 32789-32795 NNS denotes levels
T13313 32796-32798 IN denotes of
T13314 32799-32803 NNP denotes IκBα
T13315 32804-32808 VBD denotes were
T13316 32809-32813 RB denotes also
T13317 32814-32817 RB denotes not
T13318 32818-32826 JJ denotes affected
T13319 32827-32828 -LRB- denotes (
T13320 32828-32834 NN denotes Figure
T13321 32835-32836 CD denotes 8
T13322 32836-32837 -RRB- denotes )
T13323 32837-32838 . denotes .
T13324 32839-32844 DT denotes These
T13325 32845-32853 NNS denotes findings
T13326 32854-32861 VBP denotes suggest
T13327 32862-32866 IN denotes that
T13328 32867-32877 NN denotes inhibition
T13329 32878-32880 IN denotes of
T13330 32881-32886 NNP denotes Stat3
T13331 32887-32890 MD denotes can
T13332 32891-32897 VB denotes induce
T13333 32898-32902 NN denotes cell
T13334 32903-32908 NN denotes death
T13335 32909-32911 IN denotes in
T13336 32912-32916 CD denotes LMP1
T13337 32917-32927 JJ denotes transgenic
T13338 32928-32939 NNS denotes lymphocytes
T13339 32940-32943 CC denotes and
T13340 32944-32952 NN denotes lymphoma
T13341 32953-32958 NNS denotes cells
T13342 32958-32959 , denotes ,
T13343 32960-32963 CC denotes but
T13344 32964-32969 JJ denotes Stat3
T13345 32970-32980 NN denotes inhibition
T13346 32981-32985 RB denotes also
T13347 32986-32989 VBZ denotes has
T13348 32990-33002 JJ denotes considerable
T13349 33003-33012 NN denotes crossover
T13350 33013-33020 NNS denotes effects
T13351 33021-33023 IN denotes on
T13352 33024-33027 NNP denotes Akt
T13353 33028-33031 CC denotes and
T13354 33032-33036 NNP denotes NFκB
T13355 33037-33046 VBG denotes signaling
T13356 33046-33047 . denotes .
T13357 33048-33052 CD denotes LMP1
T13358 33053-33056 VBZ denotes has
T13359 33057-33061 RB denotes also
T13360 33062-33066 VBN denotes been
T13361 33067-33072 VBN denotes shown
T13362 33073-33075 TO denotes to
T13363 33076-33084 VB denotes activate
T13364 33085-33088 NNP denotes JNK
T13365 33089-33092 CC denotes and
T13366 33093-33096 CD denotes p38
T13367 33097-33101 NNP denotes MAPK
T13368 33102-33110 NNS denotes pathways
T13369 33111-33112 NNP denotes [
T13370 33112-33117 CD denotes 13,48
T13371 33117-33118 NNP denotes ]
T13372 33118-33119 , denotes ,
T13373 33120-33123 CC denotes and
T13374 33124-33128 NNP denotes LMP1
T13375 33129-33139 JJ denotes transgenic
T13376 33140-33151 NNS denotes lymphocytes
T13377 33152-33156 VBD denotes were
T13378 33157-33163 RB denotes mildly
T13379 33164-33175 JJ denotes susceptible
T13380 33176-33178 TO denotes to
T13381 33179-33185 NN denotes growth
T13382 33186-33196 NN denotes inhibition
T13383 33197-33199 IN denotes by
T13384 33200-33208 NNP denotes SB202190
T13385 33208-33209 , denotes ,
T13386 33210-33212 DT denotes an
T13387 33213-33222 NN denotes inhibitor
T13388 33223-33225 IN denotes of
T13389 33226-33229 CD denotes p38
T13390 33230-33234 NNP denotes MAPK
T13391 33234-33235 , denotes ,
T13392 33236-33239 CC denotes but
T13393 33240-33243 RB denotes not
T13394 33244-33249 NNP denotes U0126
T13395 33249-33250 , denotes ,
T13396 33251-33253 DT denotes an
T13397 33254-33263 NN denotes inhibitor
T13398 33264-33266 IN denotes of
T13399 33267-33273 NNP denotes MEK1/2
T13400 33274-33282 NN denotes activity
T13401 33282-33283 . denotes .
T13402 33284-33291 RB denotes However
T13403 33291-33292 , denotes ,
T13404 33293-33300 NNS denotes effects
T13405 33301-33303 IN denotes of
T13406 33304-33312 CD denotes SB202190
T13407 33313-33317 VBD denotes were
T13408 33318-33322 RB denotes only
T13409 33323-33331 JJ denotes apparent
T13410 33332-33334 IN denotes at
T13411 33335-33339 JJ denotes high
T13412 33340-33345 NNS denotes doses
T13413 33346-33347 -LRB- denotes (
T13414 33347-33348 CD denotes >
T13415 33348-33350 CD denotes 10
T13416 33351-33353 NNP denotes μM
T13417 33353-33354 -RRB- denotes )
T13418 33354-33355 , denotes ,
T13419 33356-33360 RB denotes much
T13420 33361-33367 JJR denotes higher
T13421 33368-33372 IN denotes than
T13422 33373-33376 DT denotes the
T13423 33377-33385 VBN denotes reported
T13424 33386-33390 NNP denotes IC50
T13425 33391-33393 IN denotes of
T13426 33394-33398 CD denotes 0.35
T13427 33399-33401 NNP denotes μM
T13428 33401-33402 , denotes ,
T13429 33403-33413 VBG denotes suggesting
T13430 33414-33418 IN denotes that
T13431 33419-33422 CD denotes p38
T13432 33423-33427 NNP denotes MAPK
T13433 33428-33432 VBZ denotes does
T13434 33433-33436 RB denotes not
T13435 33437-33450 RB denotes significantly
T13436 33451-33461 VB denotes contribute
T13437 33462-33464 TO denotes to
T13438 33465-33468 DT denotes the
T13439 33469-33477 JJ denotes enhanced
T13440 33478-33487 NN denotes viability
T13441 33488-33490 IN denotes in
T13442 33491-33495 CD denotes LMP1
T13443 33496-33506 JJ denotes transgenic
T13444 33507-33518 NNS denotes lymphocytes
T13445 33519-33521 CC denotes or
T13446 33522-33530 NN denotes lymphoma
T13447 33531-33536 NNS denotes cells
T13448 33537-33538 -LRB- denotes (
T13449 33538-33544 NN denotes Figure
T13450 33545-33546 CD denotes 7
T13451 33546-33547 -RRB- denotes )
T13452 33547-33548 . denotes .
T13453 33549-33562 RB denotes Interestingly
T13454 33562-33563 , denotes ,
T13455 33564-33568 DT denotes both
T13456 33569-33578 JJ denotes wild-type
T13457 33579-33582 CC denotes and
T13458 33583-33587 JJ denotes LMP1
T13459 33588-33598 JJ denotes transgenic
T13460 33599-33608 NNS denotes lymphomas
T13461 33609-33613 VBD denotes were
T13462 33614-33623 RB denotes similarly
T13463 33624-33635 JJ denotes susceptible
T13464 33636-33638 TO denotes to
T13465 33639-33650 VB denotes triciribine
T13466 33650-33651 , denotes ,
T13467 33652-33657 NNP denotes BAY11
T13468 33658-33662 CD denotes 7085
T13469 33662-33663 , denotes ,
T13470 33664-33667 CC denotes and
T13471 33668-33680 NN denotes cucurbitacin
T13472 33681-33682 PRP denotes I
T13473 33683-33693 NNS denotes treatments
T13474 33693-33694 , denotes ,
T13475 33695-33698 CC denotes but
T13476 33699-33702 RB denotes not
T13477 33703-33711 NNP denotes SB202190
T13478 33711-33712 , denotes ,
T13479 33713-33718 NNP denotes AG490
T13480 33718-33719 , denotes ,
T13481 33720-33722 CC denotes or
T13482 33723-33728 NNP denotes U0126
T13483 33729-33738 NN denotes treatment
T13484 33738-33739 , denotes ,
T13485 33740-33750 VBG denotes suggesting
T13486 33751-33755 IN denotes that
T13487 33756-33766 NN denotes activation
T13488 33767-33769 IN denotes of
T13489 33770-33773 NNP denotes Akt
T13490 33773-33774 , denotes ,
T13491 33775-33779 NNP denotes NFκB
T13492 33779-33780 , denotes ,
T13493 33781-33784 CC denotes and
T13494 33785-33790 NNP denotes Stat3
T13495 33791-33794 CC denotes but
T13496 33795-33798 RB denotes not
T13497 33799-33803 NNP denotes MAPK
T13498 33804-33812 NNS denotes pathways
T13499 33813-33816 VBP denotes are
T13500 33817-33832 NNS denotes characteristics
T13501 33833-33843 VBN denotes associated
T13502 33844-33848 IN denotes with
T13503 33849-33858 JJ denotes malignant
T13504 33859-33873 NN denotes transformation
T13505 33874-33875 -LRB- denotes (
T13506 33875-33881 NN denotes Figure
T13507 33882-33883 CD denotes 7
T13508 33883-33884 -RRB- denotes )
T13509 33884-33885 . denotes .
T13510 33886-33895 NN denotes rapamycin
T13511 33895-33896 , denotes ,
T13512 33897-33899 DT denotes an
T13513 33900-33909 NN denotes inhibitor
T13514 33910-33912 IN denotes of
T13515 33913-33917 NNP denotes mTOR
T13516 33917-33918 , denotes ,
T13517 33919-33922 VBD denotes did
T13518 33923-33926 RB denotes not
T13519 33927-33933 VB denotes affect
T13520 33934-33937 DT denotes the
T13521 33938-33947 NN denotes viability
T13522 33948-33950 IN denotes of
T13523 33951-33954 DT denotes the
T13524 33955-33965 JJ denotes transgenic
T13525 33966-33977 NNS denotes lymphocytes
T13526 33978-33980 CC denotes or
T13527 33981-33989 NN denotes lymphoma
T13528 33990-33995 NNS denotes cells
T13529 33995-33996 , denotes ,
T13530 33997-34007 VBG denotes confirming
T13531 34008-34012 IN denotes that
T13532 34013-34017 NNP denotes mTOR
T13533 34018-34020 VBZ denotes is
T13534 34021-34024 RB denotes not
T13535 34025-34033 VBN denotes targeted
T13536 34034-34036 IN denotes by
T13537 34037-34040 NNP denotes Akt
T13538 34041-34051 NN denotes activation
T13539 34052-34054 IN denotes in
T13540 34055-34059 CD denotes LMP1
T13541 34060-34070 JJ denotes transgenic
T13542 34071-34082 NNS denotes lymphocytes
T13543 34083-34085 CC denotes or
T13544 34086-34095 JJ denotes malignant
T13545 34096-34104 NN denotes lymphoma
T13546 34105-34110 NNS denotes cells
T13547 34111-34112 -LRB- denotes (
T13548 34112-34118 NN denotes Figure
T13549 34119-34120 CD denotes 7
T13550 34120-34121 -RRB- denotes )
T13551 34121-34122 . denotes .
T16112 34135-34139 DT denotes This
T16113 34140-34145 NN denotes study
T16114 34146-34153 VBZ denotes defines
T16115 34154-34157 DT denotes the
T16116 34158-34167 JJ denotes oncogenic
T16117 34168-34178 NNS denotes properties
T16118 34179-34181 IN denotes of
T16119 34182-34186 CD denotes LMP1
T16120 34187-34189 IN denotes in
T16121 34190-34199 VBG denotes promoting
T16122 34200-34201 NNP denotes B
T16123 34202-34206 NN denotes cell
T16124 34207-34222 NN denotes lymphomagenesis
T16125 34222-34223 . denotes .
T16126 34224-34228 CD denotes LMP1
T16127 34229-34239 JJ denotes transgenic
T16128 34240-34244 NNS denotes mice
T16129 34245-34249 VBP denotes have
T16130 34250-34251 DT denotes a
T16131 34252-34258 JJR denotes higher
T16132 34259-34268 NN denotes incidence
T16133 34269-34271 IN denotes of
T16134 34272-34280 NN denotes lymphoma
T16135 34281-34282 NNP denotes [
T16136 34282-34284 CD denotes 26
T16137 34284-34285 NNP denotes ]
T16138 34286-34289 CC denotes and
T16139 34290-34293 DT denotes the
T16140 34294-34305 NN denotes progression
T16141 34306-34308 TO denotes to
T16142 34309-34317 NN denotes lymphoma
T16143 34318-34328 NNS denotes correlates
T16144 34329-34333 IN denotes with
T16145 34334-34340 JJR denotes higher
T16146 34341-34351 NN denotes expression
T16147 34352-34358 NNS denotes levels
T16148 34359-34361 IN denotes of
T16149 34362-34366 NNP denotes LMP1
T16150 34367-34368 -LRB- denotes (
T16151 34368-34374 NNP denotes Figure
T16152 34375-34377 NNP denotes 1A
T16153 34378-34381 CC denotes and
T16154 34382-34384 NNP denotes 1B
T16155 34384-34385 -RRB- denotes )
T16156 34385-34386 , denotes ,
T16157 34387-34397 VBG denotes suggesting
T16158 34398-34402 IN denotes that
T16159 34403-34407 NNP denotes LMP1
T16160 34408-34410 VBZ denotes is
T16161 34411-34419 RB denotes directly
T16162 34420-34428 VBN denotes involved
T16163 34429-34431 IN denotes in
T16164 34432-34437 NN denotes tumor
T16165 34438-34449 NN denotes development
T16166 34449-34450 . denotes .
T16167 34451-34456 NNP denotes Table
T16168 34457-34458 CD denotes 1
T16169 34459-34469 VBZ denotes summarizes
T16170 34470-34473 DT denotes the
T16171 34474-34484 JJ denotes biological
T16172 34485-34488 CC denotes and
T16173 34489-34498 JJ denotes molecular
T16174 34499-34509 NNS denotes properties
T16175 34510-34514 WDT denotes that
T16176 34515-34519 VBD denotes were
T16177 34520-34530 VBN denotes identified
T16178 34531-34533 IN denotes in
T16179 34534-34543 JJ denotes wild-type
T16180 34544-34547 CC denotes and
T16181 34548-34552 JJ denotes LMP1
T16182 34553-34563 JJ denotes transgenic
T16183 34564-34573 NNS denotes lymphomas
T16184 34573-34574 . denotes .
T16185 34575-34583 IN denotes Although
T16186 34584-34588 JJ denotes many
T16187 34589-34591 IN denotes of
T16188 34592-34595 DT denotes the
T16189 34596-34605 JJ denotes molecular
T16190 34606-34616 NNS denotes properties
T16191 34617-34624 VBN denotes studied
T16192 34625-34629 VBD denotes were
T16193 34630-34637 JJ denotes similar
T16194 34638-34645 IN denotes between
T16195 34646-34655 JJ denotes wild-type
T16196 34656-34659 CC denotes and
T16197 34660-34664 JJ denotes LMP1
T16198 34665-34675 JJ denotes transgenic
T16199 34676-34685 NNS denotes lymphomas
T16200 34685-34686 , denotes ,
T16201 34687-34692 EX denotes there
T16202 34693-34697 VBD denotes were
T16203 34698-34712 VBG denotes distinguishing
T16204 34713-34723 JJ denotes biological
T16205 34724-34734 NNS denotes properties
T16206 34734-34735 , denotes ,
T16207 34736-34742 RB denotes namely
T16208 34743-34746 DT denotes the
T16209 34747-34754 NN denotes ability
T16210 34755-34757 IN denotes of
T16211 34758-34762 CD denotes LMP1
T16212 34763-34773 JJ denotes transgenic
T16213 34774-34783 NNS denotes lymphomas
T16214 34784-34786 TO denotes to
T16215 34787-34793 VB denotes induce
T16216 34794-34800 JJR denotes higher
T16217 34801-34807 NNS denotes levels
T16218 34808-34810 IN denotes of
T16219 34811-34819 NN denotes survival
T16220 34820-34823 CC denotes and
T16221 34824-34837 NN denotes proliferation
T16222 34837-34838 . denotes .
T16223 34839-34852 RB denotes Interestingly
T16224 34852-34853 , denotes ,
T16225 34854-34862 IN denotes although
T16226 34863-34867 JJ denotes LMP1
T16227 34868-34878 JJ denotes transgenic
T16228 34879-34883 NNS denotes mice
T16229 34884-34891 VBP denotes develop
T16230 34892-34901 NNS denotes lymphomas
T16231 34902-34904 IN denotes in
T16232 34905-34908 DT denotes the
T16233 34909-34913 JJ denotes same
T16234 34914-34918 NN denotes B-1a
T16235 34919-34923 NN denotes cell
T16236 34924-34928 NN denotes type
T16237 34929-34931 IN denotes as
T16238 34932-34943 JJ denotes spontaneous
T16239 34944-34953 JJ denotes wild-type
T16240 34954-34963 NNS denotes lymphomas
T16241 34964-34965 -LRB- denotes (
T16242 34965-34971 NN denotes Figure
T16243 34972-34973 CD denotes 2
T16244 34973-34974 -RRB- denotes )
T16245 34974-34975 , denotes ,
T16246 34976-34980 DT denotes some
T16247 34981-34990 VBG denotes signaling
T16248 34991-34998 NNS denotes effects
T16249 34999-35006 VBN denotes induced
T16250 35007-35009 IN denotes by
T16251 35010-35014 NNP denotes LMP1
T16252 35015-35018 MD denotes may
T16253 35019-35026 VB denotes explain
T16254 35027-35030 DT denotes the
T16255 35031-35039 JJ denotes enhanced
T16256 35040-35049 NN denotes promotion
T16257 35050-35052 TO denotes to
T16258 35053-35068 NN denotes lymphomagenesis
T16259 35068-35069 . denotes .
T16260 35070-35075 IN denotes Since
T16261 35076-35090 JJ denotes CD40-deficient
T16262 35091-35095 NNS denotes mice
T16263 35096-35100 VBP denotes have
T16264 35101-35110 VBN denotes decreased
T16265 35111-35118 NNS denotes numbers
T16266 35119-35121 IN denotes of
T16267 35122-35135 NNP denotes IgMhighIgDlow
T16268 35136-35141 NNS denotes cells
T16269 35141-35142 , denotes ,
T16270 35143-35144 DT denotes a
T16271 35145-35154 NN denotes phenotype
T16272 35155-35165 VBN denotes associated
T16273 35166-35170 IN denotes with
T16274 35171-35174 JJ denotes B-1
T16275 35174-35175 , denotes ,
T16276 35176-35184 JJ denotes marginal
T16277 35185-35189 NN denotes zone
T16278 35189-35190 , denotes ,
T16279 35191-35194 CC denotes and
T16280 35195-35201 NN denotes memory
T16281 35202-35203 NNP denotes B
T16282 35204-35209 NNS denotes cells
T16283 35209-35210 , denotes ,
T16284 35211-35214 DT denotes the
T16285 35215-35222 NN denotes mimicry
T16286 35223-35225 IN denotes of
T16287 35226-35230 NNP denotes CD40
T16288 35231-35240 VBG denotes signaling
T16289 35241-35243 IN denotes by
T16290 35244-35248 NNP denotes LMP1
T16291 35249-35254 MD denotes could
T16292 35255-35263 RB denotes possibly
T16293 35264-35274 VB denotes contribute
T16294 35275-35277 TO denotes to
T16295 35278-35281 DT denotes the
T16296 35282-35291 NN denotes expansion
T16297 35292-35294 IN denotes of
T16298 35295-35298 JJ denotes B-1
T16299 35299-35304 NNS denotes cells
T16300 35305-35306 NNP denotes [
T16301 35306-35308 CD denotes 20
T16302 35308-35309 NNP denotes ]
T16303 35309-35310 . denotes .
T16304 35311-35313 PRP denotes It
T16305 35314-35316 VBZ denotes is
T16306 35317-35327 JJ denotes noteworthy
T16307 35328-35332 IN denotes that
T16308 35333-35343 NN denotes expression
T16309 35344-35346 IN denotes of
T16310 35347-35351 CD denotes LMP1
T16311 35352-35354 IN denotes in
T16312 35355-35365 JJ denotes transgenic
T16313 35366-35370 NNS denotes mice
T16314 35371-35374 VBZ denotes has
T16315 35375-35379 VBN denotes been
T16316 35380-35385 VBN denotes shown
T16317 35386-35388 TO denotes to
T16318 35389-35396 VB denotes inhibit
T16319 35397-35400 DT denotes the
T16320 35401-35410 NN denotes formation
T16321 35411-35413 IN denotes of
T16322 35414-35417 NNP denotes GCs
T16323 35418-35419 NNP denotes [
T16324 35419-35424 CD denotes 23,49
T16325 35424-35425 NNP denotes ]
T16326 35425-35426 , denotes ,
T16327 35427-35437 VBG denotes preventing
T16328 35438-35445 JJ denotes typical
T16329 35446-35449 NN denotes B-2
T16330 35450-35455 NNS denotes cells
T16331 35456-35460 IN denotes from
T16332 35461-35475 JJ denotes antigen-driven
T16333 35476-35485 NN denotes selection
T16334 35486-35489 CC denotes and
T16335 35490-35499 NN denotes expansion
T16336 35499-35500 . denotes .
T16337 35501-35504 DT denotes The
T16338 35505-35509 NN denotes lack
T16339 35510-35512 IN denotes of
T16340 35513-35515 NNP denotes GC
T16341 35516-35525 NNS denotes reactions
T16342 35526-35529 MD denotes may
T16343 35530-35540 VB denotes contribute
T16344 35541-35543 TO denotes to
T16345 35544-35547 DT denotes the
T16346 35548-35552 NN denotes bias
T16347 35553-35555 IN denotes of
T16348 35556-35560 CD denotes LMP1
T16349 35561-35571 JJ denotes transgenic
T16350 35572-35576 NNS denotes mice
T16351 35577-35584 IN denotes towards
T16352 35585-35588 JJ denotes B-1
T16353 35589-35593 NN denotes cell
T16354 35594-35603 NNS denotes lymphomas
T16355 35603-35604 . denotes .
T16356 35605-35618 RB denotes Interestingly
T16357 35618-35619 , denotes ,
T16358 35620-35624 NNP denotes LMP2
T16359 35625-35634 VBG denotes signaling
T16360 35635-35639 RB denotes also
T16361 35640-35646 VBZ denotes favors
T16362 35647-35658 NN denotes development
T16363 35659-35661 IN denotes of
T16364 35662-35665 JJ denotes B-1
T16365 35666-35671 NNS denotes cells
T16366 35671-35672 , denotes ,
T16367 35673-35676 CC denotes but
T16368 35677-35681 DT denotes this
T16369 35682-35688 VBZ denotes occurs
T16370 35689-35691 IN denotes in
T16371 35692-35695 DT denotes the
T16372 35696-35703 NN denotes absence
T16373 35704-35706 IN denotes of
T16374 35707-35721 NN denotes transformation
T16375 35721-35722 . denotes .
T16376 35723-35728 DT denotes These
T16377 35729-35736 NNS denotes results
T16378 35737-35744 VBP denotes suggest
T16379 35745-35749 IN denotes that
T16380 35750-35753 DT denotes the
T16381 35754-35761 NN denotes mimicry
T16382 35762-35764 IN denotes of
T16383 35765-35766 NNP denotes B
T16384 35767-35771 NN denotes cell
T16385 35772-35780 NN denotes receptor
T16386 35781-35790 VBG denotes signaling
T16387 35791-35793 IN denotes by
T16388 35794-35798 NNP denotes LMP2
T16389 35799-35807 VBZ denotes promotes
T16390 35808-35811 JJ denotes B-1
T16391 35812-35816 NN denotes cell
T16392 35817-35832 NN denotes differentiation
T16393 35833-35836 CC denotes but
T16394 35837-35840 RB denotes not
T16395 35841-35855 NN denotes transformation
T16396 35856-35857 NNP denotes [
T16397 35857-35865 CD denotes 24,50,51
T16398 35865-35866 NNP denotes ]
T16399 35866-35867 . denotes .
T16400 35868-35872 DT denotes This
T16401 35873-35882 NN denotes promotion
T16402 35883-35885 IN denotes of
T16403 35886-35889 JJ denotes B-1
T16404 35890-35905 NN denotes differentiation
T16405 35906-35909 MD denotes may
T16406 35910-35917 VB denotes account
T16407 35918-35921 IN denotes for
T16408 35922-35925 DT denotes the
T16409 35926-35933 NN denotes ability
T16410 35934-35936 IN denotes of
T16411 35937-35941 CD denotes LMP2
T16412 35942-35944 TO denotes to
T16413 35945-35955 VB denotes exacerbate
T16414 35956-35968 NN denotes autoimmunity
T16415 35969-35972 CC denotes and
T16416 35973-35979 NN denotes bypass
T16417 35980-35986 NN denotes anergy
T16418 35987-35996 NN denotes induction
T16419 35997-35998 NNP denotes [
T16420 35998-36003 CD denotes 52,53
T16421 36003-36004 NNP denotes ]
T16422 36004-36005 . denotes .
T16423 36006-36008 IN denotes In
T16424 36009-36017 NN denotes contrast
T16425 36017-36018 , denotes ,
T16426 36019-36022 DT denotes the
T16427 36023-36036 NN denotes preponderance
T16428 36037-36039 IN denotes of
T16429 36040-36046 NNS denotes tumors
T16430 36047-36049 IN denotes of
T16431 36050-36054 JJ denotes B-1a
T16432 36055-36061 NN denotes origin
T16433 36062-36066 VBZ denotes does
T16434 36067-36070 RB denotes not
T16435 36071-36078 VB denotes reflect
T16436 36079-36086 NNS denotes effects
T16437 36087-36089 IN denotes of
T16438 36090-36094 CD denotes LMP1
T16439 36095-36104 VBG denotes signaling
T16440 36105-36107 IN denotes on
T16441 36108-36109 NNP denotes B
T16442 36110-36114 NN denotes cell
T16443 36115-36130 NN denotes differentiation
T16444 36130-36131 , denotes ,
T16445 36132-36134 IN denotes as
T16446 36135-36142 JJ denotes splenic
T16447 36143-36144 NNP denotes B
T16448 36145-36150 NNS denotes cells
T16449 36151-36155 IN denotes from
T16450 36156-36163 JJ denotes healthy
T16451 36164-36168 NNP denotes LMP1
T16452 36169-36179 NN denotes transgenic
T16453 36180-36184 NNS denotes mice
T16454 36185-36192 VBP denotes contain
T16455 36193-36200 JJ denotes similar
T16456 36201-36208 NNS denotes numbers
T16457 36209-36211 IN denotes of
T16458 36212-36215 JJ denotes B-1
T16459 36216-36219 CC denotes and
T16460 36220-36223 JJ denotes B-2
T16461 36224-36229 NNS denotes cells
T16462 36230-36232 IN denotes as
T16463 36233-36242 JJ denotes wild-type
T16464 36243-36247 NNS denotes mice
T16465 36247-36248 . denotes .
T16466 36249-36251 IN denotes In
T16467 36252-36259 NN denotes support
T16468 36260-36262 IN denotes of
T16469 36263-36267 DT denotes this
T16470 36268-36272 NN denotes lack
T16471 36273-36275 IN denotes of
T16472 36276-36282 NN denotes effect
T16473 36282-36283 , denotes ,
T16474 36284-36287 DT denotes the
T16475 36288-36303 NN denotes differentiation
T16476 36304-36306 IN denotes of
T16477 36307-36310 JJ denotes B-1
T16478 36311-36317 CC denotes versus
T16479 36318-36321 JJ denotes B-2
T16480 36322-36327 NNS denotes cells
T16481 36328-36330 VBZ denotes is
T16482 36331-36338 VBN denotes thought
T16483 36339-36341 TO denotes to
T16484 36342-36344 VB denotes be
T16485 36345-36356 JJ denotes independent
T16486 36357-36359 IN denotes of
T16487 36360-36364 CD denotes CD40
T16488 36365-36374 VBG denotes signaling
T16489 36375-36376 NNP denotes [
T16490 36376-36378 CD denotes 54
T16491 36378-36379 NNP denotes ]
T16492 36379-36380 . denotes .
T16493 36381-36384 JJ denotes B-1
T16494 36385-36390 NNS denotes cells
T16495 36391-36401 VBP denotes constitute
T16496 36402-36405 DT denotes the
T16497 36406-36417 JJ denotes predominant
T16498 36418-36428 NN denotes lymphocyte
T16499 36429-36439 NN denotes population
T16500 36440-36442 IN denotes in
T16501 36443-36446 DT denotes the
T16502 36447-36457 JJ denotes peritoneal
T16503 36458-36461 CC denotes and
T16504 36462-36479 JJ denotes pleuropericardial
T16505 36480-36488 NNS denotes cavities
T16506 36488-36489 , denotes ,
T16507 36490-36495 IN denotes while
T16508 36496-36499 NNP denotes B-2
T16509 36500-36505 NNS denotes cells
T16510 36506-36509 VBP denotes are
T16511 36510-36516 RB denotes mainly
T16512 36517-36522 VBN denotes found
T16513 36523-36525 IN denotes in
T16514 36526-36529 DT denotes the
T16515 36530-36536 NN denotes spleen
T16516 36536-36537 , denotes ,
T16517 36538-36543 VBP denotes lymph
T16518 36544-36548 NN denotes node
T16519 36548-36549 , denotes ,
T16520 36550-36553 CC denotes and
T16521 36554-36564 JJ denotes peripheral
T16522 36565-36570 NN denotes blood
T16523 36570-36571 . denotes .
T16524 36572-36575 JJ denotes B-1
T16525 36576-36581 NNS denotes cells
T16526 36582-36589 VBP denotes produce
T16527 36590-36593 DT denotes the
T16528 36594-36598 JJ denotes main
T16529 36599-36605 NN denotes source
T16530 36606-36608 IN denotes of
T16531 36609-36612 NNP denotes IgM
T16532 36613-36616 CC denotes and
T16533 36617-36620 NNP denotes IgA
T16534 36621-36631 NNS denotes antibodies
T16535 36632-36634 IN denotes in
T16536 36635-36640 NN denotes serum
T16537 36640-36641 , denotes ,
T16538 36642-36647 WDT denotes which
T16539 36648-36651 VBP denotes are
T16540 36652-36660 VBN denotes involved
T16541 36661-36663 IN denotes in
T16542 36664-36665 NNP denotes T
T16543 36666-36670 NN denotes cell
T16544 36671-36682 JJ denotes independent
T16545 36683-36692 NNS denotes responses
T16546 36693-36695 TO denotes to
T16547 36696-36702 JJ denotes common
T16548 36703-36712 JJ denotes microbial
T16549 36713-36721 NNS denotes antigens
T16550 36721-36722 . denotes .
T16551 36723-36734 RB denotes Importantly
T16552 36734-36735 , denotes ,
T16553 36736-36739 JJ denotes B-1
T16554 36740-36745 NNS denotes cells
T16555 36746-36750 VBP denotes have
T16556 36751-36754 DT denotes the
T16557 36755-36761 JJ denotes unique
T16558 36762-36770 NN denotes capacity
T16559 36771-36773 TO denotes to
T16560 36774-36778 NN denotes self
T16561 36779-36788 VB denotes replenish
T16562 36789-36792 CC denotes and
T16563 36793-36796 VBP denotes are
T16564 36797-36801 RB denotes also
T16565 36802-36813 VBN denotes predisposed
T16566 36814-36816 TO denotes to
T16567 36817-36831 NN denotes transformation
T16568 36832-36833 NNP denotes [
T16569 36833-36838 CD denotes 28,29
T16570 36838-36839 NNP denotes ]
T16571 36839-36840 . denotes .
T16572 36841-36847 JJ denotes Clonal
T16573 36848-36857 NN denotes expansion
T16574 36858-36860 IN denotes of
T16575 36861-36864 JJ denotes B-1
T16576 36865-36870 NNS denotes cells
T16577 36871-36874 MD denotes can
T16578 36875-36877 VB denotes be
T16579 36878-36886 VBN denotes detected
T16580 36887-36889 IN denotes in
T16581 36890-36895 VBG denotes aging
T16582 36896-36900 NNS denotes mice
T16583 36901-36906 IN denotes above
T16584 36907-36909 CD denotes 18
T16585 36910-36912 NN denotes mo
T16586 36913-36915 IN denotes of
T16587 36916-36919 NN denotes age
T16588 36919-36920 , denotes ,
T16589 36921-36924 CC denotes and
T16590 36925-36928 JJ denotes B-1
T16591 36929-36934 NNS denotes cells
T16592 36935-36938 VBP denotes are
T16593 36939-36946 VBN denotes thought
T16594 36947-36949 TO denotes to
T16595 36950-36952 VB denotes be
T16596 36953-36956 DT denotes the
T16597 36957-36963 NN denotes murine
T16598 36964-36974 NN denotes progenitor
T16599 36975-36977 IN denotes of
T16600 36978-36979 NNP denotes B
T16601 36980-36984 NN denotes cell
T16602 36985-36992 NN denotes chronic
T16603 36993-37004 JJ denotes lymphocytic
T16604 37005-37013 NN denotes leukemia
T16605 37014-37015 NNP denotes [
T16606 37015-37017 CD denotes 30
T16607 37017-37018 NNP denotes ]
T16608 37018-37019 . denotes .
T16609 37020-37023 DT denotes The
T16610 37024-37028 NNS denotes data
T16611 37029-37038 VBN denotes presented
T16612 37039-37041 IN denotes in
T16613 37042-37046 DT denotes this
T16614 37047-37052 NN denotes study
T16615 37053-37061 VBP denotes indicate
T16616 37062-37066 IN denotes that
T16617 37067-37075 IN denotes although
T16618 37076-37080 NNP denotes LMP1
T16619 37081-37083 VBZ denotes is
T16620 37084-37093 VBN denotes expressed
T16621 37094-37096 IN denotes in
T16622 37097-37100 DT denotes all
T16623 37101-37102 NNP denotes B
T16624 37103-37114 NNS denotes lymphocytes
T16625 37115-37117 IN denotes in
T16626 37118-37121 DT denotes the
T16627 37122-37132 JJ denotes transgenic
T16628 37133-37137 NNS denotes mice
T16629 37137-37138 , denotes ,
T16630 37139-37149 NN denotes malignancy
T16631 37150-37158 VBZ denotes develops
T16632 37159-37161 IN denotes in
T16633 37162-37166 DT denotes this
T16634 37167-37175 JJ denotes specific
T16635 37176-37182 NN denotes subset
T16636 37183-37185 IN denotes of
T16637 37186-37187 NNP denotes B
T16638 37188-37193 NNS denotes cells
T16639 37193-37194 . denotes .
T16640 37195-37198 DT denotes The
T16641 37199-37207 JJ denotes elevated
T16642 37208-37218 NN denotes expression
T16643 37219-37221 IN denotes of
T16644 37222-37226 CD denotes LMP1
T16645 37227-37229 IN denotes in
T16646 37230-37234 JJ denotes B-1a
T16647 37235-37240 NNS denotes cells
T16648 37241-37244 CC denotes and
T16649 37245-37248 DT denotes the
T16650 37249-37259 NN denotes activation
T16651 37260-37262 IN denotes of
T16652 37263-37271 JJ denotes specific
T16653 37272-37280 NNS denotes pathways
T16654 37281-37291 RB denotes apparently
T16655 37292-37298 VBP denotes induce
T16656 37299-37308 JJ denotes malignant
T16657 37309-37315 NN denotes growth
T16658 37315-37316 . denotes .
T16659 37317-37322 DT denotes These
T16660 37323-37327 JJ denotes same
T16661 37328-37336 NNS denotes pathways
T16662 37337-37340 MD denotes can
T16663 37341-37345 RB denotes also
T16664 37346-37352 VB denotes become
T16665 37353-37365 RB denotes sporadically
T16666 37366-37375 VBN denotes activated
T16667 37376-37378 IN denotes in
T16668 37379-37383 VBN denotes aged
T16669 37384-37388 NNS denotes mice
T16670 37389-37392 CC denotes and
T16671 37393-37397 RB denotes also
T16672 37398-37404 VB denotes result
T16673 37405-37407 IN denotes in
T16674 37408-37416 NN denotes lymphoma
T16675 37417-37428 NN denotes development
T16676 37428-37429 . denotes .
T16677 37430-37434 DT denotes This
T16678 37435-37437 VBZ denotes is
T16679 37438-37445 JJ denotes similar
T16680 37446-37448 TO denotes to
T16681 37449-37463 JJ denotes EBV-associated
T16682 37464-37471 NNS denotes cancers
T16683 37472-37474 IN denotes in
T16684 37475-37479 NN denotes vivo
T16685 37479-37480 , denotes ,
T16686 37481-37486 WRB denotes where
T16687 37487-37495 NNS denotes pathways
T16688 37496-37500 WDT denotes that
T16689 37501-37504 VBP denotes are
T16690 37505-37514 VBN denotes activated
T16691 37515-37517 IN denotes by
T16692 37518-37522 NNP denotes LMP1
T16693 37523-37526 VBP denotes are
T16694 37527-37531 RB denotes also
T16695 37532-37541 VBN denotes activated
T16696 37542-37544 IN denotes in
T16697 37545-37548 DT denotes the
T16698 37549-37553 JJR denotes less
T16699 37554-37563 JJ denotes prevalent
T16700 37564-37576 JJ denotes EBV-negative
T16701 37577-37582 NNS denotes forms
T16702 37583-37585 IN denotes of
T16703 37586-37589 DT denotes the
T16704 37590-37597 NNS denotes cancers
T16705 37598-37599 NNP denotes [
T16706 37599-37604 CD denotes 40,55
T16707 37605-37607 CD denotes 58
T16708 37607-37608 NN denotes ]
T16709 37608-37609 . denotes .
T16710 37610-37614 RB denotes Thus
T16711 37614-37615 , denotes ,
T16712 37616-37619 DT denotes the
T16713 37620-37632 NN denotes contribution
T16714 37633-37635 IN denotes of
T16715 37636-37639 NNP denotes EBV
T16716 37640-37643 CC denotes and
T16717 37644-37648 NNP denotes LMP1
T16718 37649-37651 TO denotes to
T16719 37652-37657 NN denotes tumor
T16720 37658-37669 NN denotes development
T16721 37670-37672 VBZ denotes is
T16722 37673-37683 RB denotes apparently
T16723 37684-37687 DT denotes the
T16724 37688-37698 JJ denotes continuous
T16725 37699-37709 NN denotes activation
T16726 37710-37712 IN denotes of
T16727 37713-37721 NNS denotes pathways
T16728 37722-37726 WDT denotes that
T16729 37727-37730 MD denotes can
T16730 37731-37735 RB denotes also
T16731 37736-37738 VB denotes be
T16732 37739-37751 RB denotes sporadically
T16733 37752-37761 VBN denotes activated
T16734 37762-37765 CC denotes and
T16735 37766-37776 VBP denotes contribute
T16736 37777-37779 TO denotes to
T16737 37780-37785 NN denotes tumor
T16738 37786-37797 NN denotes development
T16739 37797-37798 . denotes .
T16740 37799-37802 DT denotes The
T16741 37803-37812 NNS denotes lymphomas
T16742 37813-37817 VBD denotes were
T16743 37818-37824 VBN denotes marked
T16744 37825-37827 IN denotes by
T16745 37828-37831 DT denotes the
T16746 37832-37844 NN denotes upregulation
T16747 37845-37847 IN denotes of
T16748 37848-37852 NNP denotes IL10
T16749 37852-37853 , denotes ,
T16750 37854-37866 JJ denotes constitutive
T16751 37867-37877 NN denotes activation
T16752 37878-37880 IN denotes of
T16753 37881-37886 JJ denotes Stat3
T16754 37887-37896 VBG denotes signaling
T16755 37896-37897 , denotes ,
T16756 37898-37901 CC denotes and
T16757 37902-37903 DT denotes a
T16758 37904-37915 NN denotes requirement
T16759 37916-37919 IN denotes for
T16760 37920-37930 NN denotes activation
T16761 37931-37933 IN denotes of
T16762 37934-37937 NNP denotes Akt
T16763 37937-37938 , denotes ,
T16764 37939-37943 NNP denotes NFκB
T16765 37943-37944 , denotes ,
T16766 37945-37948 CC denotes and
T16767 37949-37954 JJ denotes Stat3
T16768 37955-37963 NNS denotes pathways
T16769 37964-37965 -LRB- denotes (
T16770 37965-37972 NNS denotes Figures
T16771 37973-37974 CD denotes 5
T16772 37975-37978 CC denotes and
T16773 37979-37980 CD denotes 7
T16774 37980-37981 -RRB- denotes )
T16775 37981-37982 . denotes .
T16776 37983-37992 NNP denotes Induction
T16777 37993-37995 IN denotes of
T16778 37996-38000 NNP denotes IL10
T16779 38001-38003 VBZ denotes is
T16780 38004-38014 VBN denotes associated
T16781 38015-38019 IN denotes with
T16782 38020-38023 DT denotes the
T16783 38024-38038 NN denotes transformation
T16784 38039-38041 IN denotes of
T16785 38042-38045 JJ denotes B-1
T16786 38046-38055 NNS denotes lymphomas
T16787 38056-38058 IN denotes in
T16788 38059-38063 NNS denotes mice
T16789 38064-38065 NNP denotes [
T16790 38065-38070 CD denotes 59,60
T16791 38070-38071 NNP denotes ]
T16792 38072-38075 CC denotes and
T16793 38076-38078 VBZ denotes is
T16794 38079-38089 RB denotes frequently
T16795 38090-38100 VBN denotes associated
T16796 38101-38105 IN denotes with
T16797 38106-38118 JJ denotes EBV-positive
T16798 38119-38120 NNP denotes B
T16799 38121-38125 NN denotes cell
T16800 38126-38138 NNS denotes malignancies
T16801 38139-38145 VBG denotes acting
T16802 38146-38148 IN denotes as
T16803 38149-38150 DT denotes a
T16804 38151-38152 NNP denotes B
T16805 38153-38157 NN denotes cell
T16806 38158-38164 NN denotes growth
T16807 38165-38171 NN denotes factor
T16808 38172-38173 NNP denotes [
T16809 38173-38175 CD denotes 35
T16810 38176-38178 CD denotes 38
T16811 38178-38179 NN denotes ]
T16812 38179-38180 . denotes .
T16813 38181-38183 IN denotes In
T16814 38184-38192 NN denotes addition
T16815 38192-38193 , denotes ,
T16816 38194-38198 NNP denotes LMP1
T16817 38199-38202 VBZ denotes has
T16818 38203-38207 VBN denotes been
T16819 38208-38213 VBN denotes shown
T16820 38214-38216 TO denotes to
T16821 38217-38226 VB denotes stimulate
T16822 38227-38231 NNP denotes IL10
T16823 38232-38242 NN denotes expression
T16824 38243-38245 IN denotes in
T16825 38246-38253 NNP denotes Burkitt
T16826 38254-38262 NN denotes lymphoma
T16827 38263-38267 NN denotes cell
T16828 38268-38273 NNS denotes lines
T16829 38274-38275 NNP denotes [
T16830 38275-38280 CD denotes 61,62
T16831 38280-38281 NNP denotes ]
T16832 38281-38282 . denotes .
T16833 38283-38287 DT denotes This
T16834 38288-38296 VBZ denotes suggests
T16835 38297-38301 IN denotes that
T16836 38302-38310 IN denotes although
T16837 38311-38316 NNP denotes Stat3
T16838 38317-38319 VBZ denotes is
T16839 38320-38334 RB denotes constitutively
T16840 38335-38344 VBN denotes activated
T16841 38345-38347 IN denotes in
T16842 38348-38351 DT denotes the
T16843 38352-38360 NN denotes lymphoma
T16844 38361-38366 NNS denotes cells
T16845 38366-38367 , denotes ,
T16846 38368-38371 DT denotes the
T16847 38372-38381 NN denotes induction
T16848 38382-38384 IN denotes of
T16849 38385-38389 NNP denotes IL10
T16850 38390-38393 MD denotes may
T16851 38394-38401 RB denotes further
T16852 38402-38409 VB denotes enhance
T16853 38410-38415 JJ denotes Stat3
T16854 38416-38426 NN denotes activation
T16855 38427-38429 CC denotes or
T16856 38430-38433 MD denotes may
T16857 38434-38444 VB denotes contribute
T16858 38445-38447 TO denotes to
T16859 38448-38453 JJ denotes other
T16860 38454-38469 JJ denotes IL10-responsive
T16861 38470-38479 VBG denotes signaling
T16862 38480-38488 NNS denotes pathways
T16863 38488-38489 . denotes .
T16864 38490-38494 CD denotes LMP1
T16865 38495-38504 NNS denotes activates
T16866 38505-38509 CC denotes both
T16867 38510-38513 DT denotes the
T16868 38514-38523 JJ denotes canonical
T16869 38524-38527 CC denotes and
T16870 38528-38541 JJ denotes non-canonical
T16871 38542-38550 NNS denotes pathways
T16872 38551-38553 IN denotes of
T16873 38554-38558 NNP denotes NFκB
T16874 38559-38568 VBG denotes signaling
T16875 38569-38570 NNP denotes [
T16876 38570-38575 CD denotes 14,63
T16877 38576-38578 CD denotes 65
T16878 38578-38579 NNP denotes ]
T16879 38579-38580 , denotes ,
T16880 38581-38584 CC denotes and
T16881 38585-38595 NN denotes inhibition
T16882 38596-38598 IN denotes of
T16883 38599-38603 NNP denotes NFκB
T16884 38604-38611 VBD denotes blocked
T16885 38612-38615 DT denotes the
T16886 38616-38624 NN denotes survival
T16887 38625-38627 IN denotes of
T16888 38628-38632 CD denotes LMP1
T16889 38633-38643 JJ denotes transgenic
T16890 38644-38655 NNS denotes lymphocytes
T16891 38656-38659 CC denotes and
T16892 38660-38673 JJ denotes LMP1-positive
T16893 38674-38677 CC denotes and
T16894 38678-38679 : denotes -
T16895 38679-38687 JJ denotes negative
T16896 38688-38696 NN denotes lymphoma
T16897 38697-38702 NNS denotes cells
T16898 38702-38703 . denotes .
T16899 38704-38708 NNP denotes NFκB
T16900 38709-38712 CC denotes and
T16901 38713-38717 NNP denotes PI3K
T16902 38718-38727 VBG denotes signaling
T16903 38728-38731 VBP denotes are
T16904 38732-38739 JJ denotes crucial
T16905 38740-38743 IN denotes for
T16906 38744-38756 JJ denotes CD40-induced
T16907 38757-38770 NN denotes proliferation
T16908 38770-38771 , denotes ,
T16909 38772-38775 CC denotes and
T16910 38776-38780 NNS denotes mice
T16911 38781-38790 NN denotes deficient
T16912 38791-38794 IN denotes for
T16913 38795-38799 NNP denotes cRel
T16914 38800-38802 CC denotes or
T16915 38803-38806 DT denotes the
T16916 38807-38810 NNS denotes p85
T16917 38811-38821 JJ denotes regulatory
T16918 38822-38829 NN denotes subunit
T16919 38830-38832 IN denotes of
T16920 38833-38837 NNP denotes PI3K
T16921 38838-38841 VBP denotes are
T16922 38842-38854 JJ denotes unresponsive
T16923 38855-38857 TO denotes to
T16924 38858-38867 JJ denotes mitogenic
T16925 38868-38875 NNS denotes stimuli
T16926 38875-38876 , denotes ,
T16927 38877-38886 VBG denotes including
T16928 38887-38891 NNP denotes CD40
T16929 38892-38900 NN denotes ligation
T16930 38901-38902 NNP denotes [
T16931 38902-38904 CD denotes 66
T16932 38905-38907 CD denotes 68
T16933 38907-38908 NN denotes ]
T16934 38908-38909 . denotes .
T16935 38910-38912 PRP denotes We
T16936 38913-38917 VBP denotes have
T16937 38918-38928 RB denotes previously
T16938 38929-38934 VBN denotes shown
T16939 38935-38939 IN denotes that
T16940 38940-38944 NNP denotes cRel
T16941 38945-38947 VBZ denotes is
T16942 38948-38960 RB denotes specifically
T16943 38961-38970 VBN denotes activated
T16944 38971-38973 IN denotes in
T16945 38974-38978 DT denotes both
T16946 38979-38988 JJ denotes wild-type
T16947 38989-38992 CC denotes and
T16948 38993-38997 JJ denotes LMP1
T16949 38998-39008 JJ denotes transgenic
T16950 39009-39018 NNS denotes lymphomas
T16951 39018-39019 , denotes ,
T16952 39020-39030 VBG denotes suggesting
T16953 39031-39035 IN denotes that
T16954 39036-39046 NN denotes activation
T16955 39047-39049 IN denotes of
T16956 39050-39054 NNP denotes cRel
T16957 39055-39057 VBZ denotes is
T16958 39058-39068 VBN denotes associated
T16959 39069-39073 IN denotes with
T16960 39074-39075 NNP denotes B
T16961 39076-39080 NN denotes cell
T16962 39081-39095 NN denotes transformation
T16963 39096-39097 NNP denotes [
T16964 39097-39099 CD denotes 27
T16965 39099-39100 NNP denotes ]
T16966 39100-39101 . denotes .
T16967 39102-39105 PRP$ denotes Our
T16968 39106-39118 NNS denotes observations
T16969 39119-39126 VBP denotes suggest
T16970 39127-39131 IN denotes that
T16971 39132-39139 JJ denotes similar
T16972 39140-39142 TO denotes to
T16973 39143-39155 JJ denotes CD40-induced
T16974 39156-39169 NN denotes proliferation
T16975 39169-39170 , denotes ,
T16976 39171-39175 NNP denotes LMP1
T16977 39176-39183 VBZ denotes induces
T16978 39184-39197 NN denotes proliferation
T16979 39198-39205 IN denotes through
T16980 39206-39219 JJ denotes PI3K-mediated
T16981 39220-39230 NN denotes activation
T16982 39231-39233 IN denotes of
T16983 39234-39237 NNP denotes Akt
T16984 39238-39241 CC denotes and
T16985 39242-39252 NN denotes activation
T16986 39253-39255 IN denotes of
T16987 39256-39260 NNP denotes NFκB
T16988 39261-39271 NNS denotes components
T16989 39272-39276 JJ denotes such
T16990 39277-39279 IN denotes as
T16991 39280-39284 NNP denotes cRel
T16992 39284-39285 . denotes .
T16993 39286-39290 CD denotes CD40
T16994 39291-39295 RB denotes also
T16995 39296-39303 VBZ denotes induces
T16996 39304-39318 NN denotes downregulation
T16997 39319-39321 IN denotes of
T16998 39322-39325 DT denotes the
T16999 39326-39330 NN denotes cell
T17000 39331-39336 NN denotes cycle
T17001 39337-39346 NN denotes inhibitor
T17002 39347-39350 CD denotes p27
T17003 39351-39358 IN denotes through
T17004 39359-39360 DT denotes a
T17005 39361-39375 JJ denotes PI3K-dependent
T17006 39376-39382 NN denotes manner
T17007 39382-39383 , denotes ,
T17008 39384-39387 CC denotes and
T17009 39388-39391 DT denotes the
T17010 39392-39396 NNP denotes LMP1
T17011 39397-39405 NN denotes lymphoma
T17012 39406-39411 NNS denotes cells
T17013 39412-39416 RB denotes also
T17014 39417-39420 VBD denotes had
T17015 39421-39430 VBN denotes decreased
T17016 39431-39437 NNS denotes levels
T17017 39438-39440 IN denotes of
T17018 39441-39444 CD denotes p27
T17019 39445-39449 IN denotes with
T17020 39450-39465 NN denotes phosphorylation
T17021 39466-39468 IN denotes of
T17022 39469-39471 NNP denotes Rb
T17023 39472-39475 CC denotes and
T17024 39476-39485 VBD denotes increased
T17025 39486-39490 NNP denotes Cdk2
T17026 39491-39492 -LRB- denotes (
T17027 39492-39498 NNP denotes Figure
T17028 39499-39501 NNP denotes 6C
T17029 39501-39502 -RRB- denotes )
T17030 39503-39504 NNP denotes [
T17031 39504-39506 CD denotes 66
T17032 39506-39507 NNP denotes ]
T17033 39507-39508 . denotes .
T17034 39509-39517 IN denotes Although
T17035 39518-39522 NNP denotes LMP1
T17036 39523-39526 VBZ denotes has
T17037 39527-39531 VBN denotes been
T17038 39532-39537 VBN denotes shown
T17039 39538-39540 TO denotes to
T17040 39541-39551 VB denotes deregulate
T17041 39552-39555 DT denotes the
T17042 39556-39558 NNP denotes Rb
T17043 39559-39566 NN denotes pathway
T17044 39567-39569 IN denotes in
T17045 39570-39580 JJ denotes epithelial
T17046 39581-39586 NNS denotes cells
T17047 39587-39588 NNP denotes [
T17048 39588-39590 CD denotes 69
T17049 39590-39591 NNP denotes ]
T17050 39591-39592 , denotes ,
T17051 39593-39595 TO denotes to
T17052 39596-39599 PRP$ denotes our
T17053 39600-39609 NN denotes knowledge
T17054 39610-39614 DT denotes this
T17055 39615-39617 VBZ denotes is
T17056 39618-39621 DT denotes the
T17057 39622-39627 JJ denotes first
T17058 39628-39641 NN denotes demonstration
T17059 39642-39644 IN denotes of
T17060 39645-39649 DT denotes this
T17061 39650-39658 NN denotes property
T17062 39659-39661 IN denotes in
T17063 39662-39663 NNP denotes B
T17064 39664-39675 NNS denotes lymphocytes
T17065 39675-39676 . denotes .
T17066 39677-39680 DT denotes The
T17067 39681-39692 NN denotes requirement
T17068 39693-39696 IN denotes for
T17069 39697-39700 NNP denotes Akt
T17070 39701-39711 NN denotes activation
T17071 39712-39715 VBD denotes was
T17072 39716-39725 VBN denotes confirmed
T17073 39726-39728 IN denotes by
T17074 39729-39732 DT denotes the
T17075 39733-39741 JJ denotes striking
T17076 39742-39752 NN denotes inhibition
T17077 39753-39755 IN denotes of
T17078 39756-39764 NN denotes lymphoma
T17079 39765-39774 NN denotes viability
T17080 39775-39777 IN denotes by
T17081 39778-39789 NN denotes triciribine
T17082 39789-39790 , denotes ,
T17083 39791-39793 DT denotes an
T17084 39794-39797 NNP denotes Akt
T17085 39798-39807 NN denotes inhibitor
T17086 39807-39808 . denotes .
T17087 39809-39816 RB denotes However
T17088 39816-39817 , denotes ,
T17089 39818-39821 DT denotes the
T17090 39822-39831 VBN denotes activated
T17091 39832-39836 NN denotes pAkt
T17092 39837-39840 VBD denotes did
T17093 39841-39844 RB denotes not
T17094 39845-39849 VB denotes lead
T17095 39850-39852 TO denotes to
T17096 39853-39868 NN denotes phosphorylation
T17097 39869-39872 CC denotes and
T17098 39873-39885 NN denotes inactivation
T17099 39886-39888 IN denotes of
T17100 39889-39892 DT denotes the
T17101 39893-39903 JJ denotes downstream
T17102 39904-39910 NN denotes target
T17103 39911-39915 NNP denotes GSK3
T17104 39916-39917 -LRB- denotes (
T17105 39917-39923 NNP denotes Figure
T17106 39924-39926 NNP denotes 6A
T17107 39926-39927 -RRB- denotes )
T17108 39927-39928 . denotes .
T17109 39929-39933 DT denotes This
T17110 39934-39940 NN denotes effect
T17111 39941-39944 VBZ denotes has
T17112 39945-39949 RB denotes also
T17113 39950-39954 VBN denotes been
T17114 39955-39964 VBN denotes described
T17115 39965-39967 IN denotes in
T17116 39968-39980 JJ denotes EBV-positive
T17117 39981-39983 NNP denotes HD
T17118 39984-39992 NNS denotes biopsies
T17119 39993-39994 NNP denotes [
T17120 39994-39996 CD denotes 40
T17121 39996-39997 NNP denotes ]
T17122 39997-39998 . denotes .
T17123 39999-40001 IN denotes In
T17124 40002-40010 NN denotes contrast
T17125 40010-40011 , denotes ,
T17126 40012-40021 NN denotes rapamycin
T17127 40021-40022 , denotes ,
T17128 40023-40028 NNP denotes U0126
T17129 40028-40029 , denotes ,
T17130 40030-40033 CC denotes and
T17131 40034-40042 NNP denotes SB202190
T17132 40043-40046 VBD denotes did
T17133 40047-40050 RB denotes not
T17134 40051-40057 VB denotes affect
T17135 40058-40061 DT denotes the
T17136 40062-40070 NN denotes survival
T17137 40071-40073 IN denotes of
T17138 40074-40078 CD denotes LMP1
T17139 40079-40089 JJ denotes transgenic
T17140 40090-40101 NNS denotes lymphocytes
T17141 40102-40104 CC denotes or
T17142 40105-40108 DT denotes the
T17143 40109-40118 JJ denotes wild-type
T17144 40119-40122 CC denotes and
T17145 40123-40127 JJ denotes LMP1
T17146 40128-40138 JJ denotes transgenic
T17147 40139-40147 NN denotes lymphoma
T17148 40148-40153 NNS denotes cells
T17149 40154-40155 -LRB- denotes (
T17150 40155-40161 NN denotes Figure
T17151 40162-40164 NN denotes 7A
T17152 40164-40165 , denotes ,
T17153 40166-40168 NNP denotes 7C
T17154 40168-40169 , denotes ,
T17155 40170-40173 CC denotes and
T17156 40174-40176 NNP denotes 7E
T17157 40176-40177 -RRB- denotes )
T17158 40177-40178 . denotes .
T17159 40179-40183 DT denotes This
T17160 40184-40188 NN denotes lack
T17161 40189-40191 IN denotes of
T17162 40192-40198 NN denotes effect
T17163 40199-40201 IN denotes by
T17164 40202-40211 NN denotes rapamycin
T17165 40212-40221 VBD denotes confirmed
T17166 40222-40225 DT denotes the
T17167 40226-40233 NN denotes absence
T17168 40234-40236 IN denotes of
T17169 40237-40246 VBN denotes activated
T17170 40247-40253 NN denotes p-mTOR
T17171 40254-40260 NNS denotes levels
T17172 40261-40262 -LRB- denotes (
T17173 40262-40268 NN denotes Figure
T17174 40269-40271 NN denotes 6B
T17175 40271-40272 -RRB- denotes )
T17176 40272-40273 . denotes .
T17177 40274-40279 DT denotes These
T17178 40280-40288 NNS denotes findings
T17179 40289-40296 VBP denotes suggest
T17180 40297-40301 IN denotes that
T17181 40302-40307 JJ denotes other
T17182 40308-40311 NNP denotes Akt
T17183 40312-40319 NNS denotes targets
T17184 40320-40330 VBP denotes contribute
T17185 40331-40333 TO denotes to
T17186 40334-40343 JJ denotes malignant
T17187 40344-40355 NN denotes progression
T17188 40355-40356 . denotes .
T17189 40357-40360 CD denotes One
T17190 40361-40364 JJ denotes key
T17191 40365-40371 NN denotes target
T17192 40372-40374 VBZ denotes is
T17193 40375-40381 JJ denotes likely
T17194 40382-40385 DT denotes the
T17195 40386-40396 NN denotes inhibition
T17196 40397-40399 IN denotes of
T17197 40400-40403 DT denotes the
T17198 40404-40409 NNP denotes Fox01
T17199 40410-40423 NN denotes transcription
T17200 40424-40431 NNS denotes factors
T17201 40431-40432 . denotes .
T17202 40433-40443 NN denotes Repression
T17203 40444-40446 IN denotes of
T17204 40447-40450 DT denotes the
T17205 40451-40464 JJ denotes pro-apoptotic
T17206 40465-40478 NN denotes transcription
T17207 40479-40485 NN denotes factor
T17208 40486-40491 NNP denotes FoxO1
T17209 40492-40494 IN denotes in
T17210 40495-40496 DT denotes a
T17211 40497-40511 JJ denotes PI3K-dependent
T17212 40512-40518 NN denotes manner
T17213 40519-40522 MD denotes can
T17214 40523-40530 VB denotes inhibit
T17215 40531-40541 NN denotes expression
T17216 40542-40544 IN denotes of
T17217 40545-40549 CD denotes bcl6
T17218 40549-40550 , denotes ,
T17219 40551-40552 DT denotes a
T17220 40553-40566 NN denotes transcription
T17221 40567-40573 NN denotes factor
T17222 40574-40583 JJ denotes necessary
T17223 40584-40587 IN denotes for
T17224 40588-40590 NNP denotes GC
T17225 40591-40600 NN denotes formation
T17226 40601-40602 NNP denotes [
T17227 40602-40607 CD denotes 49,70
T17228 40607-40608 NNP denotes ]
T17229 40608-40609 . denotes .
T17230 40610-40612 PRP denotes It
T17231 40613-40616 VBZ denotes has
T17232 40617-40621 VBN denotes been
T17233 40622-40627 VBN denotes shown
T17234 40628-40632 IN denotes that
T17235 40633-40648 NN denotes overstimulation
T17236 40649-40651 IN denotes of
T17237 40652-40656 NNP denotes CD40
T17238 40657-40666 VBG denotes signaling
T17239 40667-40671 IN denotes with
T17240 40672-40681 JJ denotes agonistic
T17241 40682-40692 NNS denotes antibodies
T17242 40693-40701 VBZ denotes inhibits
T17243 40702-40704 NNP denotes GC
T17244 40705-40714 NN denotes formation
T17245 40715-40716 NNP denotes [
T17246 40716-40718 CD denotes 71
T17247 40718-40719 NNP denotes ]
T17248 40719-40720 . denotes .
T17249 40721-40730 RB denotes Similarly
T17250 40730-40731 , denotes ,
T17251 40732-40735 JJ denotes due
T17252 40736-40738 TO denotes to
T17253 40739-40746 NN denotes mimicry
T17254 40747-40749 IN denotes of
T17255 40750-40754 NNP denotes CD40
T17256 40755-40764 VBG denotes signaling
T17257 40764-40765 , denotes ,
T17258 40766-40776 JJ denotes transgenic
T17259 40777-40781 NNP denotes LMP1
T17260 40782-40786 NNS denotes mice
T17261 40787-40790 VBP denotes are
T17262 40791-40795 RB denotes also
T17263 40796-40805 JJ denotes defective
T17264 40806-40808 IN denotes in
T17265 40809-40811 NNP denotes GC
T17266 40812-40821 NN denotes formation
T17267 40822-40823 NNP denotes [
T17268 40823-40828 CD denotes 23,49
T17269 40828-40829 NNP denotes ]
T17270 40829-40830 . denotes .
T17271 40831-40834 DT denotes The
T17272 40835-40847 JJ denotes constitutive
T17273 40848-40857 VBG denotes signaling
T17274 40858-40860 IN denotes by
T17275 40861-40865 CD denotes LMP1
T17276 40866-40872 JJ denotes likely
T17277 40873-40879 NNS denotes blocks
T17278 40880-40882 NNP denotes GC
T17279 40883-40892 NN denotes formation
T17280 40893-40900 IN denotes through
T17281 40901-40915 NN denotes downregulation
T17282 40916-40918 IN denotes of
T17283 40919-40923 CD denotes bcl6
T17284 40923-40924 . denotes .
T17285 40925-40938 RB denotes Interestingly
T17286 40938-40939 , denotes ,
T17287 40940-40948 JJ denotes clinical
T17288 40949-40956 NNS denotes studies
T17289 40957-40965 VBP denotes indicate
T17290 40966-40970 IN denotes that
T17291 40971-40981 NN denotes expression
T17292 40982-40984 IN denotes of
T17293 40985-40989 CD denotes LMP1
T17294 40990-40993 CC denotes and
T17295 40994-40998 CD denotes bcl6
T17296 40999-41002 VBP denotes are
T17297 41003-41011 RB denotes mutually
T17298 41012-41021 JJ denotes exclusive
T17299 41022-41024 IN denotes in
T17300 41025-41031 JJ denotes non-HD
T17301 41032-41035 CC denotes and
T17302 41036-41045 JJ denotes classical
T17303 41046-41048 NNP denotes HD
T17304 41049-41050 NNP denotes [
T17305 41050-41055 CD denotes 72,73
T17306 41055-41056 NNP denotes ]
T17307 41056-41057 . denotes .
T17308 41058-41062 RB denotes Thus
T17309 41062-41063 , denotes ,
T17310 41064-41067 DT denotes the
T17311 41068-41072 NNP denotes LMP1
T17312 41073-41083 JJ denotes transgenic
T17313 41084-41093 NNS denotes lymphomas
T17314 41094-41100 VBP denotes mirror
T17315 41101-41108 NNS denotes aspects
T17316 41109-41111 IN denotes of
T17317 41112-41123 JJ denotes EBV-induced
T17318 41124-41126 NNP denotes HD
T17319 41126-41127 . denotes .
T17320 41128-41136 IN denotes Although
T17321 41137-41140 DT denotes the
T17322 41141-41151 NN denotes activation
T17323 41152-41154 IN denotes of
T17324 41155-41158 NNP denotes Akt
T17325 41159-41162 CC denotes and
T17326 41163-41166 DT denotes the
T17327 41167-41171 NN denotes lack
T17328 41172-41174 IN denotes of
T17329 41175-41180 NNP denotes Fox01
T17330 41181-41183 IN denotes in
T17331 41184-41187 DT denotes the
T17332 41188-41196 NN denotes lymphoma
T17333 41197-41202 NNS denotes cells
T17334 41203-41210 VBP denotes suggest
T17335 41211-41215 IN denotes that
T17336 41216-41220 CD denotes LMP1
T17337 41221-41228 VBZ denotes affects
T17338 41229-41233 CD denotes bcl6
T17339 41234-41237 CC denotes and
T17340 41238-41240 NNP denotes GC
T17341 41241-41250 NN denotes formation
T17342 41251-41258 IN denotes through
T17343 41259-41263 DT denotes this
T17344 41264-41271 NN denotes pathway
T17345 41271-41272 , denotes ,
T17346 41273-41283 NN denotes regulation
T17347 41284-41286 IN denotes of
T17348 41287-41292 JJ denotes other
T17349 41293-41301 NNP denotes Forkhead
T17350 41302-41309 NNS denotes targets
T17351 41310-41318 VBN denotes involved
T17352 41319-41321 IN denotes in
T17353 41322-41326 NN denotes cell
T17354 41327-41332 NN denotes cycle
T17355 41333-41344 NN denotes progression
T17356 41344-41345 , denotes ,
T17357 41346-41350 JJ denotes such
T17358 41351-41353 IN denotes as
T17359 41354-41357 CD denotes p27
T17360 41358-41361 CC denotes and
T17361 41362-41370 NNP denotes CyclinD2
T17362 41370-41371 , denotes ,
T17363 41372-41378 JJ denotes likely
T17364 41379-41389 VBP denotes contribute
T17365 41390-41392 TO denotes to
T17366 41393-41402 JJ denotes malignant
T17367 41403-41417 NN denotes transformation
T17368 41417-41418 . denotes .
T17369 41419-41425 RB denotes Indeed
T17370 41425-41426 , denotes ,
T17371 41427-41431 NN denotes loss
T17372 41432-41434 IN denotes of
T17373 41435-41440 JJ denotes FoxO1
T17374 41441-41451 NN denotes expression
T17375 41452-41454 IN denotes in
T17376 41455-41463 NN denotes lymphoma
T17377 41464-41469 NNS denotes cells
T17378 41470-41480 VBN denotes correlated
T17379 41481-41485 IN denotes with
T17380 41486-41487 DT denotes a
T17381 41488-41492 NN denotes loss
T17382 41493-41495 IN denotes of
T17383 41496-41499 CD denotes p27
T17384 41500-41501 -LRB- denotes (
T17385 41501-41507 NN denotes Figure
T17386 41508-41510 NN denotes 6B
T17387 41511-41514 CC denotes and
T17388 41515-41517 NN denotes 6C
T17389 41517-41518 -RRB- denotes )
T17390 41518-41519 . denotes .
T17391 41520-41528 NNP denotes CyclinD2
T17392 41529-41532 VBZ denotes has
T17393 41533-41537 RB denotes also
T17394 41538-41542 VBN denotes been
T17395 41543-41548 VBN denotes shown
T17396 41549-41551 TO denotes to
T17397 41552-41554 VB denotes be
T17398 41555-41566 VBN denotes upregulated
T17399 41567-41569 IN denotes by
T17400 41570-41574 CD denotes LMP1
T17401 41575-41582 IN denotes through
T17402 41583-41590 NN denotes release
T17403 41591-41593 IN denotes of
T17404 41594-41608 JJ denotes FoxO1-mediated
T17405 41609-41619 NN denotes repression
T17406 41620-41621 NNP denotes [
T17407 41621-41623 CD denotes 70
T17408 41623-41624 NNP denotes ]
T17409 41624-41625 . denotes .
T17410 41626-41628 IN denotes In
T17411 41629-41636 NN denotes summary
T17412 41636-41637 , denotes ,
T17413 41638-41640 IN denotes in
T17414 41641-41645 DT denotes this
T17415 41646-41656 JJ denotes transgenic
T17416 41657-41662 NN denotes model
T17417 41663-41665 IN denotes of
T17418 41666-41681 NN denotes lymphomagenesis
T17419 41681-41682 , denotes ,
T17420 41683-41687 NNP denotes LMP1
T17421 41688-41696 VBZ denotes promotes
T17422 41697-41707 NN denotes malignancy
T17423 41708-41710 IN denotes in
T17424 41711-41715 JJ denotes B-1a
T17425 41716-41721 NNS denotes cells
T17426 41721-41722 , denotes ,
T17427 41723-41724 DT denotes a
T17428 41725-41735 NN denotes population
T17429 41736-41740 WDT denotes that
T17430 41741-41743 VBZ denotes is
T17431 41744-41755 VBN denotes predisposed
T17432 41756-41758 TO denotes to
T17433 41759-41765 JJ denotes clonal
T17434 41766-41775 NN denotes expansion
T17435 41776-41780 IN denotes with
T17436 41781-41784 NN denotes age
T17437 41784-41785 . denotes .
T17438 41786-41789 DT denotes The
T17439 41790-41799 JJ denotes malignant
T17440 41800-41811 NNS denotes lymphocytes
T17441 41812-41816 VBD denotes were
T17442 41817-41830 VBN denotes distinguished
T17443 41831-41833 IN denotes by
T17444 41834-41848 RB denotes constitutively
T17445 41849-41855 JJ denotes active
T17446 41856-41861 JJ denotes Stat3
T17447 41862-41871 VBG denotes signaling
T17448 41871-41872 , denotes ,
T17449 41873-41882 VBD denotes decreased
T17450 41883-41886 CD denotes p27
T17451 41886-41887 , denotes ,
T17452 41888-41891 CC denotes and
T17453 41892-41901 VBD denotes activated
T17454 41902-41905 NNP denotes Akt
T17455 41906-41909 CC denotes and
T17456 41910-41914 NNP denotes NFκB
T17457 41915-41923 NNS denotes pathways
T17458 41923-41924 , denotes ,
T17459 41925-41935 NNS denotes properties
T17460 41936-41940 WDT denotes that
T17461 41941-41944 VBP denotes are
T17462 41945-41955 VBN denotes associated
T17463 41956-41960 IN denotes with
T17464 41961-41970 VBG denotes promoting
T17465 41971-41974 DT denotes the
T17466 41975-41981 NN denotes growth
T17467 41982-41985 CC denotes and
T17468 41986-41994 NN denotes survival
T17469 41995-41997 IN denotes of
T17470 41998-41999 NNP denotes B
T17471 42000-42011 NNS denotes lymphocytes
T17472 42011-42012 . denotes .
T17473 42013-42024 RB denotes Importantly
T17474 42024-42025 , denotes ,
T17475 42026-42029 NNP denotes Akt
T17476 42029-42030 , denotes ,
T17477 42031-42035 NNP denotes NFκB
T17478 42035-42036 , denotes ,
T17479 42037-42040 CC denotes and
T17480 42041-42046 JJ denotes Stat3
T17481 42047-42055 NNS denotes pathways
T17482 42056-42060 VBD denotes were
T17483 42061-42071 RB denotes critically
T17484 42072-42080 VBN denotes required
T17485 42081-42084 IN denotes for
T17486 42085-42088 DT denotes the
T17487 42089-42095 NN denotes growth
T17488 42096-42099 CC denotes and
T17489 42100-42108 NN denotes survival
T17490 42109-42111 IN denotes of
T17491 42112-42121 JJ denotes malignant
T17492 42122-42133 NNS denotes lymphocytes
T17493 42134-42136 RB denotes as
T17494 42137-42141 RB denotes well
T17495 42142-42144 IN denotes as
T17496 42145-42152 JJ denotes healthy
T17497 42153-42157 CD denotes LMP1
T17498 42158-42168 JJ denotes transgenic
T17499 42169-42180 NNS denotes lymphocytes
T17500 42180-42181 . denotes .
T17501 42182-42185 DT denotes The
T17502 42186-42192 NN denotes growth
T17503 42193-42195 IN denotes of
T17504 42196-42211 JJ denotes EBV-transformed
T17505 42212-42223 NNS denotes lymphocytes
T17506 42224-42228 RB denotes also
T17507 42229-42237 VBZ denotes requires
T17508 42238-42248 NN denotes activation
T17509 42249-42251 IN denotes of
T17510 42252-42256 NNP denotes NFκB
T17511 42256-42257 , denotes ,
T17512 42258-42261 CC denotes and
T17513 42262-42267 DT denotes these
T17514 42268-42275 NNS denotes studies
T17515 42276-42283 VBP denotes provide
T17516 42284-42291 NN denotes insight
T17517 42292-42296 IN denotes into
T17518 42297-42300 WRB denotes how
T17519 42301-42305 JJ denotes LMP1
T17520 42306-42317 VBZ denotes contributes
T17521 42318-42320 TO denotes to
T17522 42321-42335 JJ denotes EBV-associated
T17523 42336-42350 NN denotes transformation
T17524 42350-42351 . denotes .
T17525 42352-42355 DT denotes The
T17526 42356-42366 JJ denotes transgenic
T17527 42367-42376 NNS denotes lymphomas
T17528 42377-42383 VBP denotes mirror
T17529 42384-42392 JJ denotes multiple
T17530 42393-42400 NNS denotes aspects
T17531 42401-42403 IN denotes of
T17532 42404-42415 JJ denotes EBV-induced
T17533 42416-42422 NNS denotes tumors
T17534 42423-42426 CC denotes and
T17535 42427-42434 VBP denotes suggest
T17536 42435-42439 IN denotes that
T17537 42440-42442 IN denotes in
T17538 42443-42447 NN denotes vivo
T17539 42448-42453 DT denotes these
T17540 42454-42464 NNS denotes properties
T17541 42465-42467 IN denotes of
T17542 42468-42472 CD denotes LMP1
T17543 42473-42476 VBP denotes are
T17544 42477-42482 JJ denotes major
T17545 42483-42490 NNS denotes factors
T17546 42491-42493 IN denotes in
T17547 42494-42497 DT denotes the
T17548 42498-42509 NN denotes development
T17549 42510-42512 IN denotes of
T17550 42513-42519 NN denotes cancer
T17551 42519-42520 . denotes .
T18431 42545-42555 NNP denotes Transgenic
T18432 42556-42560 NNS denotes mice
T18433 42560-42561 . denotes .
T18434 42562-42572 NNP denotes Generation
T18435 42573-42575 IN denotes of
T18436 42576-42580 NNP denotes LMP1
T18437 42581-42585 NNS denotes mice
T18438 42586-42591 IN denotes under
T18439 42592-42595 DT denotes the
T18440 42596-42598 NNP denotes Ig
T18441 42599-42604 JJ denotes heavy
T18442 42605-42610 NN denotes chain
T18443 42611-42619 NN denotes promoter
T18444 42620-42623 CC denotes and
T18445 42624-42632 NN denotes enhancer
T18446 42633-42637 VBP denotes have
T18447 42638-42642 VBN denotes been
T18448 42643-42652 VBN denotes described
T18449 42653-42663 RB denotes previously
T18450 42664-42667 CC denotes and
T18451 42668-42672 VBD denotes were
T18452 42673-42683 VBN denotes maintained
T18453 42684-42686 IN denotes as
T18454 42687-42700 NNS denotes heterozygotes
T18455 42701-42703 IN denotes on
T18456 42704-42705 DT denotes a
T18457 42706-42711 NNP denotes Balbc
T18458 42712-42722 NN denotes background
T18459 42723-42724 NNP denotes [
T18460 42724-42726 CD denotes 26
T18461 42726-42727 NNP denotes ]
T18462 42727-42728 . denotes .
T18463 42729-42733 CD denotes LMP1
T18464 42734-42738 NNS denotes mice
T18465 42739-42743 VBD denotes were
T18466 42744-42753 VBN denotes genotyped
T18467 42754-42756 IN denotes by
T18468 42757-42765 NNP denotes Southern
T18469 42766-42770 NN denotes blot
T18470 42771-42774 CC denotes and
T18471 42775-42778 NNP denotes PCR
T18472 42779-42787 NN denotes analysis
T18473 42788-42790 IN denotes of
T18474 42791-42795 NN denotes tail
T18475 42796-42799 NN denotes DNA
T18476 42800-42802 IN denotes as
T18477 42803-42812 VBN denotes described
T18478 42813-42823 RB denotes previously
T18479 42824-42825 NNP denotes [
T18480 42825-42827 CD denotes 26
T18481 42827-42828 NNP denotes ]
T18482 42828-42829 . denotes .
T18483 42830-42836 NNP denotes Spleen
T18484 42837-42840 CC denotes and
T18485 42841-42846 JJR denotes liver
T18486 42847-42855 NNS denotes sections
T18487 42856-42860 VBD denotes were
T18488 42861-42866 VBN denotes fixed
T18489 42867-42869 IN denotes in
T18490 42870-42871 CD denotes 4
T18491 42871-42872 NN denotes %
T18492 42873-42889 NN denotes paraformaldehyde
T18493 42890-42893 CC denotes and
T18494 42894-42902 VBN denotes embedded
T18495 42903-42905 IN denotes in
T18496 42906-42914 NN denotes paraffin
T18497 42914-42915 , denotes ,
T18498 42916-42919 CC denotes and
T18499 42920-42924 JJ denotes 5-μm
T18500 42925-42933 NNS denotes sections
T18501 42934-42938 VBD denotes were
T18502 42939-42946 VBN denotes stained
T18503 42947-42951 IN denotes with
T18504 42952-42963 NN denotes hematoxylin
T18505 42964-42967 CC denotes and
T18506 42968-42973 NN denotes eosin
T18507 42974-42977 IN denotes for
T18508 42978-42995 JJ denotes histopathological
T18509 42996-43004 NN denotes analysis
T18510 43004-43005 . denotes .
T18511 43006-43015 NNP denotes Lymphomas
T18512 43016-43020 VBD denotes were
T18513 43021-43029 VBN denotes passaged
T18514 43030-43032 IN denotes by
T18515 43033-43048 JJ denotes intraperitoneal
T18516 43049-43058 NN denotes injection
T18517 43059-43061 IN denotes of
T18518 43062-43063 CD denotes 1
T18519 43064-43065 CD denotes ×
T18520 43066-43069 CD denotes 108
T18521 43070-43081 NNS denotes splenocytes
T18522 43082-43086 IN denotes into
T18523 43087-43091 NNP denotes SCID
T18524 43092-43096 NNS denotes mice
T18525 43097-43100 CC denotes and
T18526 43101-43111 JJ denotes sacrificed
T18527 43112-43116 IN denotes upon
T18528 43117-43128 NN denotes development
T18529 43129-43131 IN denotes of
T18530 43132-43134 DT denotes an
T18531 43135-43143 JJ denotes extended
T18532 43144-43151 NNS denotes abdomen
T18533 43151-43152 . denotes .
T18534 43153-43160 NNS denotes Animals
T18535 43161-43165 VBD denotes were
T18536 43166-43172 VBN denotes housed
T18537 43173-43175 IN denotes in
T18538 43176-43179 DT denotes the
T18539 43180-43191 NNP denotes Association
T18540 43192-43195 IN denotes for
T18541 43196-43206 NNP denotes Assessment
T18542 43207-43210 CC denotes and
T18543 43211-43224 NNP denotes Accreditation
T18544 43225-43228 IN denotes for
T18545 43229-43235 NNP denotes Animal
T18546 43236-43240 NNP denotes Care
T18547 43241-43249 VBD denotes approved
T18548 43250-43256 JJ denotes animal
T18549 43257-43265 NN denotes facility
T18550 43266-43268 IN denotes at
T18551 43269-43272 DT denotes the
T18552 43273-43283 NNP denotes University
T18553 43284-43286 IN denotes of
T18554 43287-43292 NNP denotes North
T18555 43293-43301 NNP denotes Carolina
T18556 43302-43304 IN denotes at
T18557 43305-43311 NNP denotes Chapel
T18558 43312-43316 NNP denotes Hill
T18559 43316-43317 . denotes .
T18560 43318-43321 DT denotes All
T18561 43322-43331 NNS denotes protocols
T18562 43332-43336 VBD denotes were
T18563 43337-43345 VBN denotes approved
T18564 43346-43348 IN denotes by
T18565 43349-43352 DT denotes the
T18566 43353-43366 JJ denotes Institutional
T18567 43367-43373 NNP denotes Animal
T18568 43374-43378 NNP denotes Care
T18569 43379-43382 CC denotes and
T18570 43383-43386 NNP denotes Use
T18571 43387-43396 NNP denotes Committee
T18572 43396-43397 . denotes .
T18800 43399-43408 NN denotes Isolation
T18801 43409-43412 CC denotes and
T18802 43413-43419 NN denotes growth
T18803 43420-43422 IN denotes of
T18804 43423-43424 NNP denotes B
T18805 43425-43430 NNS denotes cells
T18806 43430-43431 . denotes .
T18807 43432-43443 NNS denotes Splenocytes
T18808 43444-43448 VBD denotes were
T18809 43449-43457 VBN denotes prepared
T18810 43458-43460 IN denotes by
T18811 43461-43473 VBG denotes homogenizing
T18812 43474-43480 JJ denotes spleen
T18813 43481-43487 NN denotes tissue
T18814 43488-43492 IN denotes with
T18815 43493-43496 CD denotes two
T18816 43497-43504 JJ denotes frosted
T18817 43505-43511 NNS denotes slides
T18818 43512-43515 CC denotes and
T18819 43516-43522 NN denotes debris
T18820 43523-43526 VBD denotes was
T18821 43527-43535 VBN denotes filtered
T18822 43536-43543 IN denotes through
T18823 43544-43545 DT denotes a
T18824 43546-43552 JJ denotes 100-μm
T18825 43553-43557 NN denotes cell
T18826 43558-43566 NN denotes strainer
T18827 43566-43567 . denotes .
T18828 43568-43580 NNS denotes Erythrocytes
T18829 43581-43585 VBD denotes were
T18830 43586-43591 VBN denotes lysed
T18831 43592-43597 VBG denotes using
T18832 43598-43601 CD denotes 0.8
T18833 43601-43602 NN denotes %
T18834 43603-43611 NN denotes ammonium
T18835 43612-43620 NN denotes chloride
T18836 43621-43629 NN denotes solution
T18837 43630-43631 -LRB- denotes (
T18838 43631-43639 NNP denotes StemCell
T18839 43640-43652 NNPS denotes Technologies
T18840 43652-43653 -RRB- denotes )
T18841 43654-43657 IN denotes for
T18842 43658-43660 CD denotes 10
T18843 43661-43664 NN denotes min
T18844 43665-43667 IN denotes on
T18845 43668-43671 NN denotes ice
T18846 43672-43675 CC denotes and
T18847 43676-43682 VBD denotes washed
T18848 43683-43688 RB denotes twice
T18849 43689-43693 IN denotes with
T18850 43694-43697 NNP denotes PBS
T18851 43697-43698 . denotes .
T18852 43699-43700 NNP denotes B
T18853 43701-43706 NNS denotes cells
T18854 43707-43711 VBD denotes were
T18855 43712-43720 VBN denotes isolated
T18856 43721-43726 VBG denotes using
T18857 43727-43736 NN denotes CD19-MACS
T18858 43737-43742 NNS denotes beads
T18859 43743-43752 VBG denotes according
T18860 43753-43755 TO denotes to
T18861 43756-43759 DT denotes the
T18862 43760-43772 NN denotes manufacturer
T18863 43772-43774 POS denotes 's
T18864 43775-43787 NNS denotes instructions
T18865 43788-43789 -LRB- denotes (
T18866 43789-43797 NNP denotes Miltenyi
T18867 43798-43804 NNP denotes Biotec
T18868 43804-43805 -RRB- denotes )
T18869 43806-43809 CC denotes and
T18870 43810-43815 VBN denotes grown
T18871 43816-43818 IN denotes in
T18872 43819-43825 NNP denotes Iscove
T18873 43825-43827 POS denotes 's
T18874 43828-43834 NN denotes medium
T18875 43835-43847 VBN denotes supplemented
T18876 43848-43852 IN denotes with
T18877 43853-43869 JJ denotes heat-inactivated
T18878 43870-43872 CD denotes 10
T18879 43872-43873 NN denotes %
T18880 43874-43879 JJ denotes fetal
T18881 43880-43886 JJ denotes bovine
T18882 43887-43892 NN denotes serum
T18883 43893-43896 CC denotes and
T18884 43897-43919 JJ denotes antibiotic/antimycotic
T18885 43920-43921 -LRB- denotes (
T18886 43921-43926 NNP denotes GIBCO
T18887 43926-43927 -RRB- denotes )
T18888 43927-43928 . denotes .
T18889 43929-43940 NNS denotes Splenocytes
T18890 43941-43949 VBD denotes isolated
T18891 43950-43954 IN denotes from
T18892 43955-43968 JJ denotes SCID-passaged
T18893 43969-43978 NNS denotes lymphomas
T18894 43979-43988 VBD denotes consisted
T18895 43989-43991 IN denotes of
T18896 43992-43994 CD denotes 80
T18897 43994-43995 NN denotes %
T18898 43996-43998 CD denotes 90
T18899 43998-43999 NN denotes %
T18900 44000-44001 NN denotes B
T18901 44002-44007 NNS denotes cells
T18902 44008-44010 IN denotes as
T18903 44011-44021 VBN denotes determined
T18904 44022-44024 IN denotes by
T18905 44025-44029 NN denotes flow
T18906 44030-44039 NN denotes cytometry
T18907 44039-44040 , denotes ,
T18908 44041-44044 CC denotes and
T18909 44045-44049 VBD denotes were
T18910 44050-44055 RB denotes hence
T18911 44056-44059 RB denotes not
T18912 44060-44067 JJ denotes further
T18913 44068-44076 VBN denotes purified
T18914 44077-44081 IN denotes with
T18915 44082-44091 NN denotes CD19-MACS
T18916 44092-44097 NNS denotes beads
T18917 44097-44098 . denotes .
T18918 44099-44110 NNS denotes Splenocytes
T18919 44111-44115 VBD denotes were
T18920 44116-44122 VBN denotes seeded
T18921 44123-44125 IN denotes at
T18922 44126-44130 CD denotes 1.25
T18923 44131-44132 CD denotes ×
T18924 44133-44136 CD denotes 106
T18925 44137-44145 NN denotes cells/ml
T18926 44146-44149 CC denotes and
T18927 44150-44155 WRB denotes where
T18928 44156-44166 JJ denotes applicable
T18929 44166-44167 , denotes ,
T18930 44168-44179 JJ denotes recombinant
T18931 44180-44185 NN denotes mouse
T18932 44186-44189 NNP denotes IL4
T18933 44190-44193 VBD denotes was
T18934 44194-44199 VBN denotes added
T18935 44200-44202 IN denotes at
T18936 44203-44206 CD denotes 100
T18937 44207-44212 NN denotes ng/ml
T18938 44212-44213 , denotes ,
T18939 44214-44225 JJ denotes recombinant
T18940 44226-44231 NN denotes mouse
T18941 44232-44236 NNP denotes IL10
T18942 44237-44239 IN denotes at
T18943 44240-44242 CD denotes 10
T18944 44243-44248 NN denotes ng/ml
T18945 44248-44249 , denotes ,
T18946 44250-44253 CC denotes and
T18947 44254-44257 NN denotes rat
T18948 44258-44262 JJ denotes IgG1
T18949 44263-44273 JJ denotes anti-mouse
T18950 44274-44278 NNP denotes IL10
T18951 44279-44282 CC denotes and
T18952 44283-44286 VB denotes rat
T18953 44287-44291 JJ denotes IgG1
T18954 44292-44299 NN denotes isotype
T18955 44300-44307 NN denotes control
T18956 44308-44310 IN denotes at
T18957 44311-44313 CD denotes 10
T18958 44314-44316 NN denotes μg
T18959 44316-44317 NN denotes /
T18960 44317-44319 NN denotes ml
T18961 44320-44321 -LRB- denotes (
T18962 44321-44324 NNP denotes R&D
T18963 44325-44332 NNPS denotes Systems
T18964 44332-44333 -RRB- denotes )
T18965 44333-44334 . denotes .
T18966 44335-44338 IN denotes For
T18967 44339-44343 NNP denotes BrdU
T18968 44344-44357 NN denotes incorporation
T18969 44358-44364 NNS denotes assays
T18970 44364-44365 , denotes ,
T18971 44366-44377 NNS denotes splenocytes
T18972 44378-44382 VBD denotes were
T18973 44383-44389 VBN denotes pulsed
T18974 44390-44393 IN denotes for
T18975 44394-44396 CD denotes 24
T18976 44397-44398 NN denotes h
T18977 44399-44403 IN denotes with
T18978 44404-44406 CD denotes 10
T18979 44407-44409 NNP denotes μM
T18980 44410-44414 NNP denotes BrdU
T18981 44415-44416 CD denotes 1
T18982 44417-44418 LS denotes d
T18983 44419-44431 JJS denotes post-harvest
T18984 44431-44432 . denotes .
T19315 44434-44437 NNP denotes MTS
T19316 44438-44443 NN denotes assay
T19317 44443-44444 . denotes .
T19318 44445-44448 DT denotes The
T19319 44449-44450 LS denotes 3
T19320 44450-44451 : denotes -
T19321 44451-44452 -LRB- denotes (
T19322 44452-44453 CD denotes 4
T19323 44453-44454 , denotes ,
T19324 44455-44477 JJ denotes 5-dimethylthiazol-2-yl
T19325 44477-44478 -RRB- denotes )
T19326 44478-44480 SYM denotes -5
T19327 44480-44481 : denotes -
T19328 44481-44482 -LRB- denotes (
T19329 44482-44504 JJ denotes 3-carboxymethoxyphenyl
T19330 44504-44505 -RRB- denotes )
T19331 44505-44507 SYM denotes -2
T19332 44507-44508 : denotes -
T19333 44508-44509 -LRB- denotes (
T19334 44509-44522 JJ denotes 4-sulfophenyl
T19335 44522-44523 -RRB- denotes )
T19336 44523-44525 CD denotes -2
T19337 44525-44538 NN denotes H-tetrazolium
T19338 44539-44544 JJ denotes inner
T19339 44545-44549 NN denotes salt
T19340 44550-44551 -LRB- denotes (
T19341 44551-44554 NNP denotes MTS
T19342 44554-44555 -RRB- denotes )
T19343 44556-44560 NN denotes cell
T19344 44561-44587 NN denotes cytotoxicity/proliferation
T19345 44588-44594 NNS denotes assays
T19346 44595-44599 VBD denotes were
T19347 44600-44609 VBN denotes performed
T19348 44610-44615 VBG denotes using
T19349 44616-44619 DT denotes the
T19350 44620-44629 NNP denotes CellTiter
T19351 44630-44632 CD denotes 96
T19352 44633-44640 JJ denotes aqueous
T19353 44641-44653 JJ denotes one-solution
T19354 44654-44658 NN denotes cell
T19355 44659-44672 NN denotes proliferation
T19356 44673-44678 NN denotes assay
T19357 44679-44680 -LRB- denotes (
T19358 44680-44687 NNP denotes Promega
T19359 44687-44688 -RRB- denotes )
T19360 44688-44689 , denotes ,
T19361 44690-44699 VBG denotes according
T19362 44700-44702 TO denotes to
T19363 44703-44715 NN denotes manufacturer
T19364 44715-44717 POS denotes 's
T19365 44718-44730 NNS denotes instructions
T19366 44730-44731 . denotes .
T19367 44732-44735 IN denotes For
T19368 44736-44739 CD denotes IL4
T19369 44740-44747 NNS denotes studies
T19370 44747-44748 , denotes ,
T19371 44749-44760 NNS denotes splenocytes
T19372 44761-44765 VBD denotes were
T19373 44766-44774 VBN denotes cultured
T19374 44775-44778 IN denotes for
T19375 44779-44780 CD denotes 3
T19376 44781-44782 LS denotes d
T19377 44783-44785 IN denotes in
T19378 44786-44789 DT denotes the
T19379 44790-44798 NN denotes presence
T19380 44799-44801 CC denotes or
T19381 44802-44809 NN denotes absence
T19382 44810-44812 IN denotes of
T19383 44813-44816 CD denotes 100
T19384 44817-44822 JJ denotes ng/ml
T19385 44823-44826 NN denotes IL4
T19386 44826-44827 . denotes .
T19387 44828-44833 NNS denotes Cells
T19388 44834-44838 VBD denotes were
T19389 44839-44845 VBN denotes seeded
T19390 44846-44848 IN denotes on
T19391 44849-44852 NN denotes day
T19392 44853-44854 CD denotes 3
T19393 44855-44857 IN denotes in
T19394 44858-44868 NN denotes triplicate
T19395 44869-44871 IN denotes in
T19396 44872-44873 DT denotes a
T19397 44874-44881 JJ denotes 96-well
T19398 44882-44887 NN denotes plate
T19399 44888-44890 IN denotes at
T19400 44891-44894 CD denotes 2.5
T19401 44895-44896 CD denotes ×
T19402 44897-44900 CD denotes 106
T19403 44901-44909 NN denotes cells/ml
T19404 44910-44912 IN denotes at
T19405 44913-44916 CD denotes 100
T19406 44917-44919 NN denotes μl
T19407 44920-44923 IN denotes per
T19408 44924-44928 RB denotes well
T19409 44928-44929 . denotes .
T19410 44930-44933 NNP denotes MTS
T19411 44934-44941 NN denotes reagent
T19412 44942-44945 VBD denotes was
T19413 44946-44951 VBN denotes added
T19414 44952-44955 IN denotes for
T19415 44956-44957 CD denotes 4
T19416 44958-44959 NN denotes h
T19417 44960-44963 CC denotes and
T19418 44964-44974 NN denotes absorbance
T19419 44975-44978 VBD denotes was
T19420 44979-44983 VBN denotes read
T19421 44984-44986 IN denotes at
T19422 44987-44990 CD denotes 540
T19423 44991-44993 NN denotes nm
T19424 44993-44994 : denotes ;
T19425 44995-45001 NNS denotes values
T19426 45002-45009 VBN denotes plotted
T19427 45010-45014 VBD denotes were
T19428 45015-45025 VBN denotes subtracted
T19429 45026-45030 IN denotes from
T19430 45031-45037 NNS denotes blanks
T19431 45037-45038 . denotes .
T19432 45039-45042 IN denotes For
T19433 45043-45057 NN denotes neutralization
T19434 45058-45064 NNS denotes assays
T19435 45064-45065 , denotes ,
T19436 45066-45077 NNS denotes splenocytes
T19437 45078-45082 VBD denotes were
T19438 45083-45089 VBN denotes seeded
T19439 45090-45092 IN denotes at
T19440 45093-45094 CD denotes 5
T19441 45095-45096 CD denotes ×
T19442 45097-45100 CD denotes 106
T19443 45101-45109 NN denotes cells/ml
T19444 45110-45112 IN denotes at
T19445 45113-45116 CD denotes 100
T19446 45117-45119 NN denotes μl
T19447 45120-45123 IN denotes per
T19448 45124-45128 RB denotes well
T19449 45129-45131 IN denotes on
T19450 45132-45135 NN denotes day
T19451 45136-45138 IN denotes of
T19452 45139-45146 NN denotes harvest
T19453 45147-45150 CC denotes and
T19454 45151-45154 NNP denotes IL4
T19455 45154-45155 , denotes ,
T19456 45156-45159 NN denotes rat
T19457 45160-45164 NNP denotes IgG1
T19458 45165-45175 JJ denotes anti-mouse
T19459 45176-45179 NNP denotes IL4
T19460 45179-45180 , denotes ,
T19461 45181-45183 CC denotes or
T19462 45184-45187 NN denotes rat
T19463 45188-45192 JJ denotes IgG1
T19464 45193-45200 NN denotes isotype
T19465 45201-45208 NN denotes control
T19466 45209-45210 -LRB- denotes (
T19467 45210-45213 NNP denotes R&D
T19468 45214-45221 NNPS denotes Systems
T19469 45221-45222 -RRB- denotes )
T19470 45223-45227 VBD denotes were
T19471 45228-45233 VBN denotes added
T19472 45234-45236 IN denotes at
T19473 45237-45240 DT denotes the
T19474 45241-45255 NNS denotes concentrations
T19475 45256-45265 VBD denotes indicated
T19476 45266-45268 IN denotes in
T19477 45269-45272 DT denotes the
T19478 45273-45280 NNS denotes figures
T19479 45280-45281 . denotes .
T19480 45282-45290 NNS denotes Cultures
T19481 45291-45295 VBD denotes were
T19482 45296-45302 VBN denotes pulsed
T19483 45303-45306 IN denotes for
T19484 45307-45308 CD denotes 4
T19485 45309-45310 NN denotes h
T19486 45311-45315 IN denotes with
T19487 45316-45319 NNP denotes MTS
T19488 45320-45327 NN denotes reagent
T19489 45328-45329 CD denotes 1
T19490 45330-45331 LS denotes d
T19491 45332-45344 NN denotes post-seeding
T19492 45344-45345 . denotes .
T19493 45346-45349 IN denotes For
T19494 45350-45359 JJ denotes inhibitor
T19495 45360-45367 NNS denotes studies
T19496 45367-45368 , denotes ,
T19497 45369-45380 NNS denotes splenocytes
T19498 45381-45385 VBD denotes were
T19499 45386-45392 VBN denotes seeded
T19500 45393-45395 IN denotes at
T19501 45396-45397 CD denotes 1
T19502 45398-45399 CD denotes ×
T19503 45400-45403 CD denotes 107
T19504 45404-45412 NN denotes cells/ml
T19505 45413-45415 IN denotes at
T19506 45416-45419 CD denotes 100
T19507 45420-45422 NN denotes μl
T19508 45423-45426 IN denotes per
T19509 45427-45431 RB denotes well
T19510 45432-45434 IN denotes on
T19511 45435-45438 NN denotes day
T19512 45439-45441 IN denotes of
T19513 45442-45449 NN denotes harvest
T19514 45449-45450 , denotes ,
T19515 45451-45454 CC denotes and
T19516 45455-45465 NNS denotes inhibitors
T19517 45466-45470 VBD denotes were
T19518 45471-45476 VBN denotes added
T19519 45477-45479 IN denotes at
T19520 45480-45483 DT denotes the
T19521 45484-45498 NNS denotes concentrations
T19522 45499-45508 VBD denotes indicated
T19523 45509-45511 IN denotes in
T19524 45512-45515 DT denotes the
T19525 45516-45523 NNS denotes figures
T19526 45523-45524 . denotes .
T19527 45525-45528 DT denotes The
T19528 45529-45539 NNS denotes inhibitors
T19529 45540-45545 NNP denotes BAY11
T19530 45546-45550 CD denotes 7085
T19531 45550-45551 , denotes ,
T19532 45552-45561 NN denotes rapamycin
T19533 45561-45562 , denotes ,
T19534 45563-45574 NN denotes triciribine
T19535 45574-45575 , denotes ,
T19536 45576-45581 NNP denotes U0126
T19537 45581-45582 , denotes ,
T19538 45583-45591 NNP denotes SB202190
T19539 45591-45592 , denotes ,
T19540 45593-45596 CC denotes and
T19541 45597-45609 NN denotes cucurbitacin
T19542 45610-45611 PRP denotes I
T19543 45612-45616 VBD denotes were
T19544 45617-45626 VBN denotes purchased
T19545 45627-45631 IN denotes from
T19546 45632-45635 NNP denotes EMD
T19547 45636-45647 NNPS denotes Biosciences
T19548 45647-45648 . denotes .
T19549 45649-45652 IN denotes For
T19550 45653-45666 JJ denotes non-malignant
T19551 45667-45677 NN denotes splenocyte
T19552 45678-45686 NNS denotes cultures
T19553 45686-45687 , denotes ,
T19554 45688-45689 NNP denotes B
T19555 45690-45694 NN denotes cell
T19556 45695-45705 NN denotes activation
T19557 45706-45709 VBD denotes was
T19558 45710-45717 VBN denotes induced
T19559 45718-45722 IN denotes with
T19560 45723-45725 CD denotes 10
T19561 45726-45728 NN denotes μg
T19562 45728-45729 NN denotes /
T19563 45729-45731 NN denotes ml
T19564 45732-45734 IN denotes of
T19565 45735-45739 NN denotes goat
T19566 45740-45741 NN denotes F
T19567 45741-45742 -LRB- denotes (
T19568 45742-45744 NN denotes ab
T19569 45744-45745 '' denotes '
T19570 45745-45746 -RRB- denotes )
T19571 45747-45757 JJ denotes anti-mouse
T19572 45758-45761 NNP denotes IgM
T19573 45762-45763 -LRB- denotes (
T19574 45763-45770 NNP denotes Jackson
T19575 45771-45785 NNP denotes ImmunoResearch
T19576 45785-45786 -RRB- denotes )
T19577 45786-45787 . denotes .
T19578 45788-45796 NNS denotes Cultures
T19579 45797-45801 VBD denotes were
T19580 45802-45808 VBN denotes pulsed
T19581 45809-45812 IN denotes for
T19582 45813-45814 CD denotes 4
T19583 45815-45816 NN denotes h
T19584 45817-45821 IN denotes with
T19585 45822-45825 NNP denotes MTS
T19586 45826-45833 NN denotes reagent
T19587 45834-45835 CD denotes 1
T19588 45836-45837 LS denotes d
T19589 45838-45850 NN denotes post-seeding
T19590 45850-45851 . denotes .
T19824 45853-45873 NNP denotes Immunohistochemistry
T19825 45873-45874 . denotes .
T19826 45875-45892 JJ denotes Paraffin-embedded
T19827 45893-45899 JJ denotes spleen
T19828 45900-45908 NNS denotes sections
T19829 45909-45913 VBD denotes were
T19830 45914-45928 VBN denotes deparaffinized
T19831 45929-45931 IN denotes in
T19832 45932-45942 NNP denotes Histoclear
T19833 45943-45944 -LRB- denotes (
T19834 45944-45952 NNP denotes National
T19835 45953-45964 NNPS denotes Diagnostics
T19836 45964-45965 -RRB- denotes )
T19837 45966-45969 CC denotes and
T19838 45970-45980 VBD denotes rehydrated
T19839 45981-45983 IN denotes in
T19840 45984-45990 JJ denotes graded
T19841 45991-45998 NN denotes ethanol
T19842 45998-45999 . denotes .
T19843 46000-46008 NNS denotes Sections
T19844 46009-46013 VBD denotes were
T19845 46014-46021 NN denotes antigen
T19846 46022-46031 VBN denotes retrieved
T19847 46032-46034 IN denotes by
T19848 46035-46046 NN denotes microwaving
T19849 46047-46049 IN denotes in
T19850 46050-46057 JJ denotes citrate
T19851 46058-46064 NN denotes buffer
T19852 46065-46066 -LRB- denotes (
T19853 46066-46068 NNP denotes pH
T19854 46069-46072 CD denotes 6.0
T19855 46072-46073 -RRB- denotes )
T19856 46074-46077 IN denotes for
T19857 46078-46080 CD denotes 15
T19858 46081-46084 NN denotes min
T19859 46085-46086 -LRB- denotes (
T19860 46086-46090 CD denotes LMP1
T19861 46091-46099 NN denotes staining
T19862 46099-46100 -RRB- denotes )
T19863 46101-46104 CC denotes and
T19864 46105-46107 CD denotes 10
T19865 46108-46111 NN denotes min
T19866 46112-46113 -LRB- denotes (
T19867 46113-46119 JJ denotes pStat3
T19868 46120-46128 NN denotes staining
T19869 46128-46129 -RRB- denotes )
T19870 46129-46130 . denotes .
T19871 46131-46134 IN denotes For
T19872 46135-46139 CD denotes LMP1
T19873 46140-46148 NN denotes staining
T19874 46148-46149 , denotes ,
T19875 46150-46158 NNS denotes sections
T19876 46159-46163 VBD denotes were
T19877 46164-46171 VBN denotes blocked
T19878 46172-46176 IN denotes with
T19879 46177-46178 CD denotes 1
T19880 46178-46179 NN denotes %
T19881 46180-46183 NNP denotes BSA
T19882 46184-46187 CC denotes and
T19883 46188-46191 CD denotes 0.1
T19884 46191-46192 NN denotes %
T19885 46193-46197 JJ denotes cold
T19886 46198-46202 NN denotes fish
T19887 46203-46207 NN denotes skin
T19888 46208-46215 NN denotes gelatin
T19889 46216-46224 VBD denotes followed
T19890 46225-46229 IN denotes with
T19891 46230-46249 NNP denotes streptavidin/biotin
T19892 46250-46255 NN denotes block
T19893 46256-46257 -LRB- denotes (
T19894 46257-46263 NNP denotes Vector
T19895 46264-46268 NNPS denotes Labs
T19896 46268-46269 -RRB- denotes )
T19897 46269-46270 . denotes .
T19898 46271-46274 NN denotes Rat
T19899 46275-46278 NNP denotes IgG
T19900 46279-46288 NNP denotes anti-LMP1
T19901 46289-46290 -LRB- denotes (
T19902 46290-46296 NNS denotes clones
T19903 46297-46300 NNP denotes 8G3
T19904 46301-46304 CC denotes and
T19905 46305-46308 NNP denotes 1G6
T19906 46308-46309 , denotes ,
T19907 46310-46318 NNP denotes Ascenion
T19908 46318-46319 -RRB- denotes )
T19909 46320-46324 VBD denotes were
T19910 46325-46329 VBN denotes used
T19911 46330-46332 IN denotes at
T19912 46333-46337 CD denotes 1:10
T19913 46338-46346 NN denotes dilution
T19914 46347-46351 IN denotes from
T19915 46352-46358 NN denotes tissue
T19916 46359-46366 NN denotes culture
T19917 46367-46379 NNS denotes supernatants
T19918 46379-46380 , denotes ,
T19919 46381-46389 VBD denotes followed
T19920 46390-46394 IN denotes with
T19921 46395-46396 CD denotes 8
T19922 46397-46399 NN denotes μg
T19923 46399-46400 NN denotes /
T19924 46400-46402 NN denotes ml
T19925 46403-46415 VBD denotes biotinylated
T19926 46416-46421 NN denotes mouse
T19927 46422-46423 NN denotes F
T19928 46423-46424 -LRB- denotes (
T19929 46424-46426 NN denotes ab
T19930 46426-46427 '' denotes '
T19931 46427-46428 -RRB- denotes )
T19932 46429-46437 JJ denotes anti-rat
T19933 46438-46441 NNP denotes IgG
T19934 46442-46443 -LRB- denotes (
T19935 46443-46446 NNP denotes H+L
T19936 46446-46447 -RRB- denotes )
T19937 46448-46460 JJ denotes pre-adsorbed
T19938 46461-46463 TO denotes to
T19939 46464-46469 NN denotes mouse
T19940 46470-46475 NN denotes serum
T19941 46476-46477 -LRB- denotes (
T19942 46477-46484 NNP denotes Jackson
T19943 46485-46499 NNP denotes ImmunoResearch
T19944 46499-46500 -RRB- denotes )
T19945 46501-46504 CC denotes and
T19946 46505-46506 CD denotes 2
T19947 46507-46509 NN denotes μg
T19948 46509-46510 NN denotes /
T19949 46510-46512 NN denotes ml
T19950 46513-46534 JJ denotes streptavidin-alkaline
T19951 46535-46546 NN denotes phosphatase
T19952 46547-46556 NN denotes conjugate
T19953 46557-46558 -LRB- denotes (
T19954 46558-46565 NNP denotes Jackson
T19955 46566-46580 NNP denotes ImmunoResearch
T19956 46580-46581 -RRB- denotes )
T19957 46581-46582 . denotes .
T19958 46583-46589 NNS denotes Stains
T19959 46590-46594 VBD denotes were
T19960 46595-46604 VBN denotes developed
T19961 46605-46609 IN denotes with
T19962 46610-46618 NNP denotes BCIP/NBT
T19963 46619-46622 CC denotes and
T19964 46623-46637 VBN denotes counterstained
T19965 46638-46640 IN denotes in
T19966 46641-46648 NNP denotes Nuclear
T19967 46649-46653 NNP denotes Fast
T19968 46654-46657 NNP denotes Red
T19969 46658-46659 -LRB- denotes (
T19970 46659-46663 NNP denotes Dako
T19971 46663-46664 -RRB- denotes )
T19972 46664-46665 . denotes .
T19973 46666-46679 NN denotes Phospho-Stat3
T19974 46680-46683 VBD denotes was
T19975 46684-46692 VBN denotes detected
T19976 46693-46697 IN denotes with
T19977 46698-46699 CD denotes 4
T19978 46700-46702 NN denotes μg
T19979 46702-46703 NN denotes /
T19980 46703-46705 NN denotes ml
T19981 46706-46708 IN denotes of
T19982 46709-46715 JJ denotes pStat3
T19983 46716-46724 NN denotes antibody
T19984 46725-46726 -LRB- denotes (
T19985 46726-46732 NNS denotes Tyr705
T19986 46732-46733 , denotes ,
T19987 46734-46738 NNP denotes Cell
T19988 46739-46748 NNP denotes Signaling
T19989 46748-46749 -RRB- denotes )
T19990 46750-46753 CC denotes and
T19991 46754-46762 VBN denotes detected
T19992 46763-46767 IN denotes with
T19993 46768-46779 JJ denotes anti-rabbit
T19994 46780-46788 NNP denotes Poly-HRP
T19995 46789-46792 NNP denotes IHC
T19996 46793-46802 NN denotes detection
T19997 46803-46806 NN denotes kit
T19998 46807-46808 -LRB- denotes (
T19999 46808-46816 NNP denotes Chemicon
T20000 46816-46817 -RRB- denotes )
T20001 46817-46818 . denotes .
T20169 46820-46824 NN denotes Flow
T20170 46825-46834 NN denotes cytometry
T20171 46834-46835 . denotes .
T20172 46836-46839 CD denotes One
T20173 46840-46847 CD denotes million
T20174 46848-46859 NNS denotes splenocytes
T20175 46860-46864 VBD denotes were
T20176 46865-46872 VBN denotes stained
T20177 46873-46877 IN denotes with
T20178 46878-46881 DT denotes the
T20179 46882-46893 JJ denotes appropriate
T20180 46894-46901 JJ denotes primary
T20181 46902-46910 NN denotes antibody
T20182 46911-46923 JJ denotes unconjugated
T20183 46924-46926 CC denotes or
T20184 46927-46937 VBN denotes conjugated
T20185 46938-46940 TO denotes to
T20186 46941-46945 NNP denotes FITC
T20187 46945-46946 , denotes ,
T20188 46947-46949 NNP denotes PE
T20189 46949-46950 , denotes ,
T20190 46951-46953 CC denotes or
T20191 46954-46957 NNP denotes APC
T20192 46958-46965 VBN denotes diluted
T20193 46966-46968 IN denotes in
T20194 46969-46974 VB denotes stain
T20195 46975-46981 NN denotes buffer
T20196 46982-46983 -LRB- denotes (
T20197 46983-46986 NNP denotes PBS
T20198 46987-46991 IN denotes with
T20199 46992-46993 CD denotes 3
T20200 46993-46994 NN denotes %
T20201 46995-46998 NNP denotes FBS
T20202 46998-46999 -RRB- denotes )
T20203 46999-47000 . denotes .
T20204 47001-47004 IN denotes For
T20205 47005-47009 NNP denotes BrdU
T20206 47010-47019 NN denotes detection
T20207 47019-47020 , denotes ,
T20208 47021-47024 DT denotes the
T20209 47025-47034 NNP denotes FITC-BrdU
T20210 47035-47039 NN denotes flow
T20211 47040-47043 NN denotes kit
T20212 47044-47047 VBD denotes was
T20213 47048-47052 VBN denotes used
T20214 47053-47055 IN denotes as
T20215 47056-47066 VBN denotes instructed
T20216 47067-47069 IN denotes by
T20217 47070-47073 DT denotes the
T20218 47074-47086 NN denotes manufacturer
T20219 47087-47088 -LRB- denotes (
T20220 47088-47090 NNP denotes BD
T20221 47091-47101 NNP denotes Bioscience
T20222 47101-47102 -RRB- denotes )
T20223 47102-47103 . denotes .
T20224 47104-47111 RB denotes Briefly
T20225 47111-47112 , denotes ,
T20226 47113-47118 NNS denotes cells
T20227 47119-47123 VBD denotes were
T20228 47124-47131 VBN denotes exposed
T20229 47132-47134 TO denotes to
T20230 47135-47138 NNP denotes EMA
T20231 47139-47140 -LRB- denotes (
T20232 47140-47149 NNP denotes Molecular
T20233 47150-47156 NNP denotes Probes
T20234 47156-47157 -RRB- denotes )
T20235 47158-47161 IN denotes for
T20236 47162-47171 NN denotes exclusion
T20237 47172-47174 IN denotes of
T20238 47175-47179 JJ denotes dead
T20239 47180-47185 NNS denotes cells
T20240 47185-47186 , denotes ,
T20241 47187-47194 VBN denotes stained
T20242 47195-47198 IN denotes for
T20243 47199-47206 NN denotes surface
T20244 47207-47215 NNS denotes antigens
T20245 47215-47216 , denotes ,
T20246 47217-47222 VBN denotes fixed
T20247 47223-47225 IN denotes in
T20248 47226-47242 NN denotes paraformaldehyde
T20249 47242-47243 , denotes ,
T20250 47244-47247 CC denotes and
T20251 47248-47261 VBN denotes permeabilized
T20252 47262-47266 IN denotes with
T20253 47267-47274 NN denotes saponin
T20254 47274-47275 . denotes .
T20255 47276-47278 TO denotes To
T20256 47279-47285 VB denotes expose
T20257 47286-47290 NNP denotes BrdU
T20258 47291-47299 NNS denotes epitopes
T20259 47299-47300 , denotes ,
T20260 47301-47306 NNS denotes cells
T20261 47307-47311 VBD denotes were
T20262 47312-47319 VBN denotes treated
T20263 47320-47324 IN denotes with
T20264 47325-47330 NNP denotes Dnase
T20265 47331-47334 CC denotes and
T20266 47335-47342 VBN denotes stained
T20267 47343-47347 IN denotes with
T20268 47348-47363 JJ denotes FITC-conjugated
T20269 47364-47373 JJ denotes anti-BrdU
T20270 47374-47382 NN denotes antibody
T20271 47382-47383 . denotes .
T20272 47384-47388 NN denotes Flow
T20273 47389-47398 NN denotes cytometry
T20274 47399-47402 VBD denotes was
T20275 47403-47412 VBN denotes performed
T20276 47413-47415 IN denotes on
T20277 47416-47427 NNP denotes FACScalibur
T20278 47428-47433 VBG denotes using
T20279 47434-47437 DT denotes the
T20280 47438-47447 NNP denotes CellQuest
T20281 47448-47455 NN denotes program
T20282 47456-47457 -LRB- denotes (
T20283 47457-47463 NNP denotes Becton
T20284 47464-47473 NNP denotes Dickinson
T20285 47473-47474 -RRB- denotes )
T20286 47474-47475 . denotes .
T20287 47476-47483 JJ denotes Further
T20288 47484-47492 NN denotes analysis
T20289 47493-47496 VBD denotes was
T20290 47497-47506 VBN denotes conducted
T20291 47507-47509 IN denotes on
T20292 47510-47513 DT denotes the
T20293 47514-47520 NNP denotes Summit
T20294 47521-47523 CD denotes v4
T20295 47523-47525 CD denotes .2
T20296 47526-47533 NN denotes program
T20297 47534-47535 -LRB- denotes (
T20298 47535-47539 NNP denotes Dako
T20299 47539-47540 -RRB- denotes )
T20300 47540-47541 . denotes .
T20534 47543-47548 JJ denotes Rnase
T20535 47549-47559 NN denotes protection
T20536 47560-47565 NN denotes assay
T20537 47565-47566 . denotes .
T20538 47567-47572 JJ denotes Total
T20539 47573-47576 NNP denotes RNA
T20540 47577-47580 VBD denotes was
T20541 47581-47589 VBN denotes isolated
T20542 47590-47594 IN denotes from
T20543 47595-47599 CD denotes CD19
T20544 47599-47600 CD denotes +
T20545 47601-47614 JJ denotes MACS-purified
T20546 47615-47616 NNP denotes B
T20547 47617-47622 NNS denotes cells
T20548 47623-47628 VBG denotes using
T20549 47629-47632 DT denotes the
T20550 47633-47639 NNP denotes Rneasy
T20551 47640-47644 NN denotes midi
T20552 47645-47657 NN denotes purification
T20553 47658-47661 NN denotes kit
T20554 47662-47666 IN denotes with
T20555 47667-47672 NNP denotes Dnase
T20556 47673-47682 NN denotes treatment
T20557 47682-47683 , denotes ,
T20558 47684-47693 VBG denotes according
T20559 47694-47696 TO denotes to
T20560 47697-47700 DT denotes the
T20561 47701-47713 NN denotes manufacturer
T20562 47713-47715 POS denotes 's
T20563 47716-47728 NNS denotes instructions
T20564 47729-47730 -LRB- denotes (
T20565 47730-47736 NNP denotes Qiagen
T20566 47736-47737 -RRB- denotes )
T20567 47737-47738 . denotes .
T20568 47739-47742 DT denotes The
T20569 47743-47748 JJ denotes mCK-1
T20570 47749-47754 NN denotes probe
T20571 47755-47763 NN denotes template
T20572 47764-47767 NN denotes set
T20573 47768-47769 -LRB- denotes (
T20574 47769-47771 NNP denotes BD
T20575 47772-47783 NNPS denotes Biosciences
T20576 47783-47784 -RRB- denotes )
T20577 47785-47788 VBD denotes was
T20578 47789-47796 VBN denotes labeled
T20579 47797-47802 VBG denotes using
T20580 47803-47806 DT denotes the
T20581 47807-47809 NNP denotes In
T20582 47810-47815 NNP denotes Vitro
T20583 47816-47829 NNP denotes Transcription
T20584 47830-47833 NNP denotes Kit
T20585 47834-47843 VBG denotes according
T20586 47844-47846 TO denotes to
T20587 47847-47850 DT denotes the
T20588 47851-47863 NN denotes manufacturer
T20589 47863-47865 POS denotes 's
T20590 47866-47878 NNS denotes instructions
T20591 47879-47880 -LRB- denotes (
T20592 47880-47882 NNP denotes BD
T20593 47883-47894 NNPS denotes Biosciences
T20594 47894-47895 -RRB- denotes )
T20595 47895-47896 . denotes .
T20596 47897-47904 RB denotes Briefly
T20597 47904-47905 , denotes ,
T20598 47906-47908 CD denotes 50
T20599 47909-47911 NN denotes ng
T20600 47912-47914 IN denotes of
T20601 47915-47920 JJ denotes mCK-1
T20602 47921-47926 NN denotes probe
T20603 47927-47930 NN denotes set
T20604 47931-47934 VBD denotes was
T20605 47935-47942 VBN denotes labeled
T20606 47943-47947 IN denotes with
T20607 47948-47949 NNP denotes [
T20608 47949-47954 NNP denotes α-32P
T20609 47954-47955 NNP denotes ]
T20610 47955-47958 NNP denotes UTP
T20611 47959-47964 VBG denotes using
T20612 47965-47967 CD denotes T7
T20613 47968-47971 NNP denotes RNA
T20614 47972-47982 NN denotes polymerase
T20615 47983-47986 CC denotes and
T20616 47987-47995 VBD denotes purified
T20617 47996-48001 VBG denotes using
T20618 48002-48010 NNP denotes Sephadex
T20619 48011-48015 NNP denotes G-50
T20620 48016-48023 NNS denotes columns
T20621 48024-48025 -LRB- denotes (
T20622 48025-48032 NNP denotes NucAway
T20623 48033-48037 NNP denotes Spin
T20624 48038-48044 NN denotes column
T20625 48044-48045 , denotes ,
T20626 48046-48052 NNP denotes Ambion
T20627 48052-48053 -RRB- denotes )
T20628 48053-48054 . denotes .
T20629 48055-48058 DT denotes The
T20630 48059-48066 VBN denotes labeled
T20631 48067-48072 NN denotes probe
T20632 48073-48076 VBD denotes was
T20633 48077-48088 VBN denotes quantitated
T20634 48089-48094 VBG denotes using
T20635 48095-48096 DT denotes a
T20636 48097-48110 NN denotes scintillation
T20637 48111-48118 RB denotes counter
T20638 48118-48119 , denotes ,
T20639 48120-48123 CC denotes and
T20640 48124-48125 CD denotes 6
T20641 48126-48127 NN denotes ×
T20642 48128-48131 CD denotes 105
T20643 48132-48141 NN denotes cherenkov
T20644 48142-48145 NN denotes cpm
T20645 48146-48149 VBD denotes was
T20646 48150-48154 VBN denotes used
T20647 48155-48157 TO denotes to
T20648 48158-48167 VB denotes hybridize
T20649 48168-48170 TO denotes to
T20650 48171-48172 CD denotes 4
T20651 48173-48175 NN denotes μg
T20652 48176-48178 IN denotes of
T20653 48179-48184 JJ denotes total
T20654 48185-48188 NNP denotes RNA
T20655 48189-48194 VBG denotes using
T20656 48195-48198 DT denotes the
T20657 48199-48202 NNP denotes RPA
T20658 48203-48206 NN denotes kit
T20659 48207-48208 -LRB- denotes (
T20660 48208-48210 NNP denotes BD
T20661 48211-48222 NNPS denotes Biosciences
T20662 48222-48223 -RRB- denotes )
T20663 48223-48224 . denotes .
T20664 48225-48232 NNS denotes Samples
T20665 48233-48237 VBD denotes were
T20666 48238-48247 VBN denotes denatured
T20667 48248-48250 IN denotes at
T20668 48251-48253 CD denotes 90
T20669 48254-48255 CD denotes °
T20670 48255-48256 NNP denotes C
T20671 48257-48260 CC denotes and
T20672 48261-48271 VBN denotes hybridized
T20673 48272-48274 IN denotes at
T20674 48275-48277 CD denotes 56
T20675 48278-48279 CD denotes °
T20676 48279-48280 NNP denotes C
T20677 48281-48290 JJ denotes overnight
T20678 48290-48291 . denotes .
T20679 48292-48307 JJ denotes Single-stranded
T20680 48308-48311 NNP denotes RNA
T20681 48312-48315 VBD denotes was
T20682 48316-48324 VBN denotes digested
T20683 48325-48329 IN denotes with
T20684 48330-48331 DT denotes a
T20685 48332-48339 NN denotes mixture
T20686 48340-48342 IN denotes of
T20687 48343-48348 NNP denotes Rnase
T20688 48349-48350 NNP denotes A
T20689 48351-48354 CC denotes and
T20690 48355-48357 NNP denotes T1
T20691 48357-48358 , denotes ,
T20692 48359-48362 CC denotes and
T20693 48363-48375 VBD denotes precipitated
T20694 48376-48381 VBG denotes using
T20695 48382-48393 NN denotes isopropanol
T20696 48393-48394 . denotes .
T20697 48395-48404 VBN denotes Protected
T20698 48405-48411 NNS denotes probes
T20699 48412-48416 VBD denotes were
T20700 48417-48425 VBN denotes resolved
T20701 48426-48428 IN denotes on
T20702 48429-48430 DT denotes a
T20703 48431-48441 VBG denotes denaturing
T20704 48442-48446 CD denotes 4.75
T20705 48446-48447 NN denotes %
T20706 48448-48458 NN denotes acrylamide
T20707 48459-48462 NN denotes gel
T20708 48462-48463 , denotes ,
T20709 48464-48469 VBD denotes dried
T20710 48469-48470 , denotes ,
T20711 48471-48474 CC denotes and
T20712 48475-48481 VBD denotes imaged
T20713 48482-48487 VBG denotes using
T20714 48488-48489 DT denotes a
T20715 48490-48504 NNP denotes phosphorImager
T20716 48505-48506 -LRB- denotes (
T20717 48506-48515 NNP denotes Molecular
T20718 48516-48524 NNP denotes Dynamics
T20719 48524-48525 -RRB- denotes )
T20720 48525-48526 . denotes .
T20721 48527-48539 NNP denotes Densitometry
T20722 48540-48543 VBD denotes was
T20723 48544-48553 VBN denotes performed
T20724 48554-48559 VBG denotes using
T20725 48560-48563 DT denotes the
T20726 48564-48574 NNP denotes ImageQuant
T20727 48575-48577 NNP denotes TL
T20728 48578-48583 CD denotes v2005
T20729 48584-48592 NN denotes software
T20730 48593-48594 -LRB- denotes (
T20731 48594-48596 NNP denotes GE
T20732 48597-48607 NNP denotes Healthcare
T20733 48607-48608 -RRB- denotes )
T20734 48608-48609 . denotes .
T20886 48611-48614 NNP denotes PCR
T20887 48615-48623 NN denotes analysis
T20888 48624-48626 IN denotes of
T20889 48627-48628 NN denotes κ
T20890 48629-48634 NN denotes chain
T20891 48635-48648 NN denotes rearrangement
T20892 48648-48649 . denotes .
T20893 48650-48653 NNP denotes DNA
T20894 48654-48657 VBD denotes was
T20895 48658-48666 VBN denotes isolated
T20896 48667-48671 IN denotes from
T20897 48672-48683 NNS denotes splenocytes
T20898 48684-48689 VBG denotes using
T20899 48690-48693 DT denotes the
T20900 48694-48700 NNP denotes Dneasy
T20901 48701-48707 NNP denotes Tissue
T20902 48708-48711 NNP denotes Kit
T20903 48712-48713 -LRB- denotes (
T20904 48713-48719 NNP denotes Qiagen
T20905 48719-48720 -RRB- denotes )
T20906 48720-48721 , denotes ,
T20907 48722-48726 IN denotes with
T20908 48727-48732 NNP denotes Rnase
T20909 48733-48742 NN denotes treatment
T20910 48742-48743 . denotes .
T20911 48744-48747 NNP denotes PCR
T20912 48748-48757 NNS denotes reactions
T20913 48758-48767 VBD denotes contained
T20914 48768-48771 CD denotes 100
T20915 48772-48774 NN denotes ng
T20916 48775-48777 IN denotes of
T20917 48778-48785 JJ denotes genomic
T20918 48786-48789 NNP denotes DNA
T20919 48789-48790 , denotes ,
T20920 48791-48794 CD denotes 0.2
T20921 48795-48797 NNP denotes μM
T20922 48798-48802 DT denotes each
T20923 48803-48809 NN denotes primer
T20924 48809-48810 , denotes ,
T20925 48811-48814 CD denotes 0.2
T20926 48815-48817 NNP denotes mM
T20927 48818-48823 NNP denotes dNTPs
T20928 48823-48824 , denotes ,
T20929 48825-48828 CC denotes and
T20930 48829-48832 CD denotes 2.5
T20931 48833-48834 NNP denotes U
T20932 48835-48838 NNP denotes Taq
T20933 48839-48842 NNP denotes DNA
T20934 48843-48853 NN denotes polymerase
T20935 48854-48855 -LRB- denotes (
T20936 48855-48858 NNP denotes NEB
T20937 48858-48859 -RRB- denotes )
T20938 48860-48869 VBN denotes performed
T20939 48870-48872 IN denotes in
T20940 48873-48875 NNP denotes 1X
T20941 48876-48885 NNP denotes ThermoPol
T20942 48886-48892 NN denotes buffer
T20943 48893-48894 -LRB- denotes (
T20944 48894-48897 NNP denotes NEB
T20945 48897-48898 -RRB- denotes )
T20946 48898-48899 . denotes .
T20947 48900-48907 NNS denotes Primers
T20948 48908-48912 VBN denotes used
T20949 48913-48917 VBD denotes were
T20950 48918-48923 NNP denotes Vκcon
T20951 48924-48927 CC denotes and
T20952 48928-48931 NNP denotes Jκ5
T20953 48932-48933 CD denotes 1
T20954 48933-48934 CD denotes °
T20955 48935-48938 CC denotes and
T20956 48939-48943 VBP denotes have
T20957 48944-48948 VBN denotes been
T20958 48949-48958 VBN denotes described
T20959 48959-48969 RB denotes previously
T20960 48970-48971 NNP denotes [
T20961 48971-48973 CD denotes 74
T20962 48973-48974 NNP denotes ]
T20963 48974-48975 . denotes .
T20964 48976-48979 NNP denotes PCR
T20965 48980-48990 NNS denotes conditions
T20966 48991-48995 VBD denotes were
T20967 48996-48998 CD denotes 94
T20968 48999-49000 NN denotes °
T20969 49000-49001 NNP denotes C
T20970 49002-49005 IN denotes for
T20971 49006-49007 CD denotes 2
T20972 49008-49011 NN denotes min
T20973 49011-49012 , denotes ,
T20974 49013-49015 CD denotes 40
T20975 49016-49022 NNS denotes cycles
T20976 49023-49025 IN denotes of
T20977 49026-49028 CD denotes 94
T20978 49029-49030 CD denotes °
T20979 49030-49031 NNP denotes C
T20980 49032-49035 IN denotes for
T20981 49036-49038 CD denotes 30
T20982 49039-49040 PRP denotes s
T20983 49040-49041 , denotes ,
T20984 49042-49044 CD denotes 63
T20985 49045-49046 NN denotes °
T20986 49046-49047 NNP denotes C
T20987 49048-49051 IN denotes for
T20988 49052-49054 CD denotes 90
T20989 49055-49056 PRP denotes s
T20990 49056-49057 , denotes ,
T20991 49058-49061 CC denotes and
T20992 49062-49064 CD denotes 72
T20993 49065-49066 NN denotes °
T20994 49066-49067 NNP denotes C
T20995 49068-49071 IN denotes for
T20996 49072-49073 CD denotes 1
T20997 49074-49077 NN denotes min
T20998 49077-49078 , denotes ,
T20999 49079-49087 VBN denotes followed
T21000 49088-49090 IN denotes by
T21001 49091-49092 CD denotes 1
T21002 49093-49098 NN denotes cycle
T21003 49099-49101 IN denotes of
T21004 49102-49104 CD denotes 72
T21005 49105-49106 CD denotes °
T21006 49106-49107 NNP denotes C
T21007 49108-49111 IN denotes for
T21008 49112-49113 CD denotes 5
T21009 49114-49117 NN denotes min
T21010 49117-49118 . denotes .
T21195 49120-49130 NNP denotes Immunoblot
T21196 49131-49139 NN denotes analysis
T21197 49139-49140 . denotes .
T21198 49141-49146 JJ denotes Whole
T21199 49147-49151 NN denotes cell
T21200 49152-49159 NNS denotes lysates
T21201 49160-49164 VBD denotes were
T21202 49165-49173 VBN denotes prepared
T21203 49174-49176 IN denotes in
T21204 49177-49201 NN denotes radioimmunoprecipitation
T21205 49202-49207 NN denotes assay
T21206 49208-49209 -LRB- denotes (
T21207 49209-49213 NNP denotes RIPA
T21208 49213-49214 -RRB- denotes )
T21209 49215-49221 NN denotes buffer
T21210 49222-49223 -LRB- denotes (
T21211 49223-49225 CD denotes 20
T21212 49226-49228 NNP denotes mM
T21213 49229-49237 NNP denotes Tris-HCl
T21214 49238-49239 NNP denotes [
T21215 49239-49241 NNP denotes pH
T21216 49242-49245 CD denotes 7.5
T21217 49245-49246 NNP denotes ]
T21218 49246-49247 , denotes ,
T21219 49248-49251 CD denotes 150
T21220 49252-49254 NNP denotes mM
T21221 49255-49259 NNP denotes NaCl
T21222 49259-49260 , denotes ,
T21223 49261-49262 CD denotes 1
T21224 49263-49265 NNP denotes mM
T21225 49266-49270 NNP denotes EDTA
T21226 49270-49271 , denotes ,
T21227 49272-49273 CD denotes 1
T21228 49273-49274 NN denotes %
T21229 49275-49280 NN denotes NP-40
T21230 49280-49281 , denotes ,
T21231 49282-49285 CD denotes 0.1
T21232 49285-49286 NN denotes %
T21233 49287-49290 NNP denotes SDS
T21234 49290-49291 , denotes ,
T21235 49292-49295 CD denotes 0.1
T21236 49295-49296 NN denotes %
T21237 49297-49303 NN denotes sodium
T21238 49304-49316 NN denotes deoxycholate
T21239 49316-49317 -RRB- denotes )
T21240 49318-49330 VBN denotes supplemented
T21241 49331-49335 IN denotes with
T21242 49336-49337 CD denotes 2
T21243 49338-49340 NNP denotes mM
T21244 49341-49361 NN denotes phenylmethylsulfonyl
T21245 49362-49370 NN denotes fluoride
T21246 49370-49371 , denotes ,
T21247 49372-49373 CD denotes 1
T21248 49374-49376 NNP denotes mM
T21249 49377-49383 NNP denotes Na3VO4
T21250 49383-49384 , denotes ,
T21251 49385-49388 CC denotes and
T21252 49389-49394 CD denotes 1:100
T21253 49395-49415 JJ denotes protease/phosphatase
T21254 49416-49425 NN denotes inhibitor
T21255 49426-49435 NNS denotes cocktails
T21256 49436-49437 -LRB- denotes (
T21257 49437-49442 NNP denotes Sigma
T21258 49442-49443 -RRB- denotes )
T21259 49443-49444 . denotes .
T21260 49445-49450 JJ denotes Crude
T21261 49451-49458 NNS denotes lysates
T21262 49459-49463 VBD denotes were
T21263 49464-49475 VBN denotes centrifuged
T21264 49476-49478 IN denotes at
T21265 49479-49485 CD denotes 13,000
T21266 49486-49489 NN denotes rpm
T21267 49490-49493 IN denotes for
T21268 49494-49496 CD denotes 10
T21269 49497-49500 NN denotes min
T21270 49501-49503 IN denotes at
T21271 49504-49505 CD denotes 4
T21272 49506-49507 CD denotes °
T21273 49507-49508 NNP denotes C
T21274 49509-49512 CC denotes and
T21275 49513-49516 DT denotes the
T21276 49517-49529 NNS denotes supernatants
T21277 49530-49534 VBD denotes were
T21278 49535-49544 VBN denotes collected
T21279 49545-49548 IN denotes for
T21280 49549-49556 JJ denotes further
T21281 49557-49565 NN denotes analysis
T21282 49565-49566 . denotes .
T21283 49567-49574 NN denotes Protein
T21284 49575-49589 NNS denotes concentrations
T21285 49590-49594 VBD denotes were
T21286 49595-49605 VBN denotes determined
T21287 49606-49610 IN denotes with
T21288 49611-49614 DT denotes the
T21289 49615-49622 NNP denotes Bio-Rad
T21290 49623-49625 NNP denotes DC
T21291 49626-49633 NN denotes protein
T21292 49634-49639 NN denotes assay
T21293 49640-49646 NN denotes system
T21294 49646-49647 . denotes .
T21295 49648-49655 NNS denotes Lysates
T21296 49656-49660 VBD denotes were
T21297 49661-49667 VBN denotes boiled
T21298 49668-49670 IN denotes in
T21299 49671-49674 DT denotes the
T21300 49675-49683 NN denotes presence
T21301 49684-49686 IN denotes of
T21302 49687-49690 CD denotes 2.5
T21303 49690-49691 NN denotes %
T21304 49692-49708 NN denotes β-mecaptoethanol
T21305 49708-49709 , denotes ,
T21306 49710-49719 VBN denotes separated
T21307 49720-49722 IN denotes by
T21308 49723-49733 VBG denotes denaturing
T21309 49734-49742 NNP denotes SDS-PAGE
T21310 49742-49743 , denotes ,
T21311 49744-49747 CC denotes and
T21312 49748-49759 VBD denotes transferred
T21313 49760-49762 TO denotes to
T21314 49763-49767 CD denotes 0.45
T21315 49767-49768 : denotes -
T21316 49768-49770 NN denotes μm
T21317 49771-49779 NNP denotes Optitran
T21318 49780-49789 NNS denotes membranes
T21319 49790-49791 -LRB- denotes (
T21320 49791-49801 NNP denotes Schleicher
T21321 49802-49803 CC denotes &
T21322 49804-49811 NNP denotes Schuell
T21323 49811-49812 -RRB- denotes )
T21324 49813-49815 IN denotes in
T21325 49816-49817 DT denotes a
T21326 49818-49825 NNP denotes Bio-Rad
T21327 49826-49834 NN denotes transfer
T21328 49835-49839 NN denotes unit
T21329 49839-49840 . denotes .
T21330 49841-49850 NNS denotes Membranes
T21331 49851-49855 VBD denotes were
T21332 49856-49869 VBN denotes immunoblotted
T21333 49870-49874 IN denotes with
T21334 49875-49878 DT denotes the
T21335 49879-49890 JJ denotes appropriate
T21336 49891-49898 JJ denotes primary
T21337 49899-49907 NN denotes antibody
T21338 49908-49916 VBN denotes followed
T21339 49917-49919 IN denotes by
T21340 49920-49931 JJ denotes horseradish
T21341 49932-49942 NN denotes peroxidase
T21342 49943-49949 VBD denotes tagged
T21343 49950-49959 JJ denotes secondary
T21344 49960-49970 NNS denotes antibodies
T21345 49971-49972 -LRB- denotes (
T21346 49972-49980 NNP denotes Amersham
T21347 49981-49992 NNPS denotes Biosciences
T21348 49993-49996 CC denotes and
T21349 49997-50001 NNP denotes Dako
T21350 50001-50002 -RRB- denotes )
T21351 50003-50006 CC denotes and
T21352 50007-50015 VBN denotes detected
T21353 50016-50020 IN denotes with
T21354 50021-50024 DT denotes the
T21355 50025-50036 NNP denotes SuperSignal
T21356 50037-50041 NNP denotes West
T21357 50042-50046 NNP denotes Pico
T21358 50047-50053 NNP denotes System
T21359 50054-50055 -LRB- denotes (
T21360 50055-50061 NNP denotes Pierce
T21361 50061-50062 -RRB- denotes )
T21362 50062-50063 . denotes .
T21474 50065-50075 NNS denotes Antibodies
T21475 50075-50076 . denotes .
T21476 50077-50092 JJ denotes FITC-conjugated
T21477 50093-50097 NN denotes goat
T21478 50098-50108 JJ denotes anti-mouse
T21479 50109-50112 NNP denotes IgM
T21480 50112-50113 , denotes ,
T21481 50114-50117 NN denotes rat
T21482 50118-50124 NNP denotes IgG2aκ
T21483 50125-50135 JJ denotes anti-mouse
T21484 50136-50139 NNP denotes IgD
T21485 50140-50141 -LRB- denotes (
T21486 50141-50146 VBP denotes clone
T21487 50147-50149 CD denotes 11
T21488 50150-50152 CD denotes 26
T21489 50152-50153 -RRB- denotes )
T21490 50153-50154 , denotes ,
T21491 50155-50158 NN denotes rat
T21492 50159-50164 NNP denotes IgG1κ
T21493 50165-50175 JJ denotes anti-mouse
T21494 50176-50181 NN denotes kappa
T21495 50182-50183 -LRB- denotes (
T21496 50183-50188 JJ denotes clone
T21497 50189-50194 CD denotes 187.1
T21498 50194-50195 -RRB- denotes )
T21499 50195-50196 , denotes ,
T21500 50197-50200 NN denotes rat
T21501 50201-50207 NNP denotes IgG2bκ
T21502 50208-50218 JJ denotes anti-mouse
T21503 50219-50225 NN denotes lambda
T21504 50226-50227 -LRB- denotes (
T21505 50227-50232 JJ denotes clone
T21506 50233-50236 NNS denotes JC5
T21507 50237-50238 LS denotes 1
T21508 50238-50239 -RRB- denotes )
T21509 50239-50240 : denotes ;
T21510 50241-50254 VBN denotes PE-conjugated
T21511 50255-50259 NN denotes goat
T21512 50260-50270 NN denotes anti-mouse
T21513 50271-50274 NNP denotes IgG
T21514 50274-50275 : denotes ;
T21515 50276-50289 JJ denotes un-conjugated
T21516 50290-50294 JJ denotes goat
T21517 50295-50305 JJ denotes anti-mouse
T21518 50306-50311 NN denotes kappa
T21519 50312-50315 CC denotes and
T21520 50316-50326 JJ denotes anti-mouse
T21521 50327-50333 NNS denotes lambda
T21522 50334-50338 VBD denotes were
T21523 50339-50348 VBN denotes purchased
T21524 50349-50353 IN denotes from
T21525 50354-50362 NNP denotes Southern
T21526 50363-50370 NNP denotes Biotech
T21527 50370-50371 . denotes .
T21528 50372-50386 JJ denotes APC-conjugated
T21529 50387-50390 NN denotes rat
T21530 50391-50397 NNP denotes IgG2aκ
T21531 50398-50408 JJ denotes anti-mouse
T21532 50409-50413 NNP denotes CD19
T21533 50414-50415 -LRB- denotes (
T21534 50415-50420 VBN denotes clone
T21535 50421-50424 NNP denotes 6D5
T21536 50424-50425 -RRB- denotes )
T21537 50425-50426 , denotes ,
T21538 50427-50440 JJ denotes PE-conjugated
T21539 50441-50446 NN denotes mouse
T21540 50447-50453 NNP denotes IgG2aκ
T21541 50454-50463 NNP denotes anti-LMP1
T21542 50464-50465 -LRB- denotes (
T21543 50465-50470 VBN denotes clone
T21544 50471-50474 NNP denotes S12
T21545 50474-50475 -RRB- denotes )
T21546 50475-50476 , denotes ,
T21547 50477-50490 JJ denotes un-conjugated
T21548 50491-50496 NN denotes mouse
T21549 50497-50502 NNP denotes IgG2a
T21550 50503-50510 NNP denotes anti-Rb
T21551 50511-50512 -LRB- denotes (
T21552 50512-50517 VBN denotes clone
T21553 50518-50519 LS denotes 2
T21554 50519-50520 -RRB- denotes )
T21555 50520-50521 , denotes ,
T21556 50522-50525 CC denotes and
T21557 50526-50535 JJ denotes anti-Cdk2
T21558 50536-50537 -LRB- denotes (
T21559 50537-50542 JJ denotes clone
T21560 50543-50545 CD denotes 55
T21561 50545-50546 -RRB- denotes )
T21562 50547-50551 VBD denotes were
T21563 50552-50561 VBN denotes purchased
T21564 50562-50566 IN denotes from
T21565 50567-50569 NNP denotes BD
T21566 50570-50580 NNP denotes Bioscience
T21567 50580-50581 . denotes .
T21568 50582-50595 JJ denotes PE-conjugated
T21569 50596-50599 NN denotes rat
T21570 50600-50606 NNP denotes IgG2aκ
T21571 50607-50617 JJ denotes anti-mouse
T21572 50618-50621 NNS denotes CD5
T21573 50622-50623 -LRB- denotes (
T21574 50623-50628 NN denotes clone
T21575 50629-50631 CD denotes 53
T21576 50632-50635 CD denotes 7.3
T21577 50635-50636 -RRB- denotes )
T21578 50637-50640 VBD denotes was
T21579 50641-50650 VBN denotes purchased
T21580 50651-50655 IN denotes from
T21581 50656-50667 NNP denotes eBioscience
T21582 50667-50668 . denotes .
T21583 50669-50672 NN denotes Rat
T21584 50673-50682 NN denotes anti-LMP1
T21585 50683-50684 -LRB- denotes (
T21586 50684-50690 NNS denotes clones
T21587 50691-50694 NNP denotes 8G3
T21588 50694-50695 , denotes ,
T21589 50696-50699 NNP denotes 1G6
T21590 50699-50700 , denotes ,
T21591 50701-50705 NNP denotes 7E10
T21592 50705-50706 , denotes ,
T21593 50707-50710 CC denotes and
T21594 50711-50714 NNP denotes 7G8
T21595 50714-50715 -RRB- denotes )
T21596 50716-50719 VBD denotes was
T21597 50720-50729 VBN denotes purchased
T21598 50730-50734 IN denotes from
T21599 50735-50743 NNP denotes Ascenion
T21600 50743-50744 . denotes .
T21601 50745-50751 NN denotes Rabbit
T21602 50752-50761 JJ denotes anti-pAkt
T21603 50762-50763 -LRB- denotes (
T21604 50763-50769 JJ denotes Ser473
T21605 50769-50770 -RRB- denotes )
T21606 50770-50771 , denotes ,
T21607 50772-50783 JJ denotes anti-pGSK3α
T21608 50783-50784 NN denotes /
T21609 50784-50785 NN denotes β
T21610 50786-50787 -LRB- denotes (
T21611 50787-50794 CD denotes Ser21/9
T21612 50794-50795 -RRB- denotes )
T21613 50795-50796 , denotes ,
T21614 50797-50808 JJ denotes anti-pStat3
T21615 50809-50810 -LRB- denotes (
T21616 50810-50816 NNS denotes Tyr705
T21617 50816-50817 -RRB- denotes )
T21618 50817-50818 , denotes ,
T21619 50819-50830 JJ denotes anti-pStat6
T21620 50831-50832 -LRB- denotes (
T21621 50832-50838 NNP denotes Tyr641
T21622 50838-50839 -RRB- denotes )
T21623 50839-50840 , denotes ,
T21624 50841-50851 JJ denotes anti-pmTOR
T21625 50852-50853 -LRB- denotes (
T21626 50853-50860 CD denotes Ser2448
T21627 50860-50861 -RRB- denotes )
T21628 50861-50862 , denotes ,
T21629 50863-50873 JJ denotes anti-Stat6
T21630 50873-50874 , denotes ,
T21631 50875-50883 JJ denotes anti-Akt
T21632 50883-50884 , denotes ,
T21633 50885-50895 JJ denotes anti-FoxO1
T21634 50895-50896 , denotes ,
T21635 50897-50900 CC denotes and
T21636 50901-50909 JJ denotes anti-p27
T21637 50910-50914 VBD denotes were
T21638 50915-50924 VBN denotes purchased
T21639 50925-50929 IN denotes from
T21640 50930-50934 NNP denotes Cell
T21641 50935-50944 NNP denotes Signaling
T21642 50944-50945 . denotes .
T21643 50946-50952 NN denotes Rabbit
T21644 50953-50963 NN denotes anti-Stat3
T21645 50964-50965 -LRB- denotes (
T21646 50965-50970 NNP denotes H-190
T21647 50970-50971 -RRB- denotes )
T21648 50971-50972 , denotes ,
T21649 50973-50982 JJ denotes anti-IκBα
T21650 50983-50984 -LRB- denotes (
T21651 50984-50988 NN denotes C-21
T21652 50988-50989 -RRB- denotes )
T21653 50989-50990 , denotes ,
T21654 50991-50994 CC denotes and
T21655 50995-50999 NN denotes goat
T21656 51000-51006 JJ denotes anti-β
T21657 51007-51012 NN denotes actin
T21658 51013-51014 -LRB- denotes (
T21659 51014-51018 NN denotes I-19
T21660 51018-51019 -RRB- denotes )
T21661 51020-51024 VBD denotes were
T21662 51025-51034 VBN denotes purchased
T21663 51035-51039 IN denotes from
T21664 51040-51045 NNP denotes Santa
T21665 51046-51050 NNP denotes Cruz
T21666 51051-51064 NNP denotes Biotechnology
T21667 51064-51065 . denotes .
T21668 51066-51071 NNP denotes Mouse
T21669 51072-51077 NNP denotes IgG1κ
T21670 51078-51087 NN denotes anti-GSK3
T21671 51088-51091 VBD denotes was
T21672 51092-51101 VBN denotes purchased
T21673 51102-51106 IN denotes from
T21674 51107-51114 NNP denotes Upstate
T21675 51115-51128 NNP denotes Biotechnology
T21676 51128-51129 . denotes .
T21677 51130-51136 NN denotes Rabbit
T21678 51137-51145 JJ denotes anti-pRb
T21679 51146-51147 -LRB- denotes (
T21680 51147-51153 JJ denotes Thr373
T21681 51153-51154 -RRB- denotes )
T21682 51155-51158 VBD denotes was
T21683 51159-51168 VBN denotes purchased
T21684 51169-51173 IN denotes from
T21685 51174-51177 NNP denotes EMD
T21686 51178-51189 NNPS denotes Biosciences
T21687 51189-51190 . denotes .
T21815 8478-8482 NNP denotes High
T21816 8483-8487 NNP denotes LMP1
T21817 8488-8498 NNP denotes Expression
T21818 8499-8509 NNPS denotes Correlates
T21819 8510-8514 IN denotes with
T21820 8515-8518 DT denotes the
T21821 8519-8530 NNP denotes Development
T21857 8702-8712 JJ denotes transgenic
T21858 8713-8717 NNS denotes mice
T21859 8717-8718 . denotes .
T21860 8719-8720 -LRB- denotes (
T21861 8720-8721 NNP denotes A
T21862 8721-8722 -RRB- denotes )
T21863 8723-8732 NNP denotes Lymphomas
T21864 8733-8736 VBP denotes are
T21865 8737-8747 VBN denotes identified
T21866 8748-8752 IN denotes with
T21867 8753-8754 DT denotes a
T21868 8755-8761 NN denotes number
T21869 8762-8763 -LRB- denotes (
T21870 8763-8764 CD denotes 1
T21871 8765-8766 CD denotes 7
T21872 8766-8767 -RRB- denotes )
T21873 8767-8768 . denotes .
T21874 8769-8775 NNS denotes Arrows
T21875 8776-8784 VBP denotes indicate
T21876 8785-8788 DT denotes the
T21877 8789-8802 JJ denotes LMP1-specific
T21878 8803-8807 NN denotes band
T21879 8808-8811 CC denotes and
T21880 8812-8815 PRP$ denotes its
T21881 8816-8827 NN denotes degradation
T21882 8828-8836 NNS denotes products
T21883 8837-8839 RB denotes as
T21884 8840-8844 RB denotes well
T21885 8845-8847 IN denotes as
T22333 10554-10558 CD denotes LMP1
T22334 10559-10567 NNP denotes Promotes
T22335 10568-10572 NNP denotes B-1a
T22336 10573-10582 NNP denotes Lymphomas
T22337 10583-10587 WDT denotes That
T22338 10588-10591 MD denotes Can
T22339 10592-10598 VB denotes Escape
T22340 10599-10606 NNP denotes Allelic
T22341 10607-10616 NNP denotes Exclusion
T22342 10617-10618 -LRB- denotes (
T22343 10618-10619 NNP denotes A
T22344 10619-10620 -RRB- denotes )
T22345 10621-10625 NNP denotes Flow
T22346 10626-10635 NN denotes cytometry
T22347 10636-10644 NN denotes analysis
T22348 10645-10647 IN denotes of
T22349 10648-10659 NNS denotes splenocytes
T22350 10660-10664 IN denotes from
T22351 10665-10666 DT denotes a
T22352 10667-10669 NNP denotes WT
T22353 10670-10672 CC denotes or
T22354 10673-10677 NNP denotes LMP1
T22355 10678-10688 JJ denotes transgenic
T22356 10689-10697 NN denotes lymphoma
T22357 10698-10701 IN denotes for
T22358 10702-10705 DT denotes the
T22359 10706-10709 VB denotes pan
T22360 10710-10711 NNP denotes B
T22361 10712-10716 NN denotes cell
T22362 10717-10718 -LRB- denotes (
T22363 10718-10722 CD denotes CD19
T22364 10722-10723 -RRB- denotes )
T22365 10723-10724 , denotes ,
T22366 10725-10729 JJ denotes B-1a
T22367 10730-10734 NN denotes cell
T22368 10735-10736 -LRB- denotes (
T22369 10736-10739 CD denotes CD5
T22370 10739-10740 -RRB- denotes )
T22371 10740-10741 , denotes ,
T22372 10742-10745 CC denotes and
T22373 10746-10748 NNP denotes Ig
T22374 10749-10754 JJ denotes heavy
T22375 10755-10760 NN denotes chain
T22376 10761-10762 -LRB- denotes (
T22377 10762-10765 NNP denotes IgM
T22378 10766-10769 CC denotes and
T22379 10770-10773 NNP denotes IgD
T22380 10773-10774 -RRB- denotes )
T22381 10775-10778 CC denotes and
T22382 10779-10784 JJ denotes light
T22383 10785-10790 NN denotes chain
T22384 10791-10792 -LRB- denotes (
T22385 10792-10793 NN denotes κ
T22386 10794-10797 CC denotes and
T22387 10798-10799 NN denotes λ
T22388 10799-10800 -RRB- denotes )
T22389 10801-10808 NNS denotes markers
T22390 10808-10809 . denotes .
T22391 10810-10815 VBN denotes Shown
T22392 10816-10819 VBP denotes are
T22393 10820-10823 DT denotes the
T22394 10824-10831 NNS denotes results
T22395 10832-10836 IN denotes from
T22396 10837-10839 NNP denotes WT
T22397 10840-10848 NN denotes lymphoma
T22398 10849-10850 CD denotes 1
T22399 10851-10854 CC denotes and
T22400 10855-10859 CD denotes LMP1
T22401 10860-10870 JJ denotes transgenic
T22402 10871-10879 NN denotes lymphoma
T22403 10880-10881 CD denotes 4
T22404 10881-10882 . denotes .
T22405 10883-10887 DT denotes This
T22406 10888-10896 NN denotes analysis
T22407 10897-10900 VBD denotes was
T22408 10901-10909 VBN denotes repeated
T22409 10910-10912 IN denotes on
T22410 10913-10917 CD denotes four
T22411 10918-10923 JJ denotes other
T22412 10924-10928 NNP denotes LMP1
T22413 10929-10939 NN denotes transgenic
T22414 10940-10949 NNS denotes lymphomas
T22415 10950-10951 -LRB- denotes (
T22416 10951-10952 CD denotes 1
T22417 10952-10953 , denotes ,
T22418 10954-10955 CD denotes 2
T22419 10955-10956 , denotes ,
T22420 10957-10958 CD denotes 3
T22421 10958-10959 , denotes ,
T22422 10960-10963 CC denotes and
T22423 10964-10965 CD denotes 6
T22424 10965-10966 -RRB- denotes )
T22425 10967-10974 VBG denotes showing
T22426 10975-10976 DT denotes a
T22427 10977-10984 JJ denotes similar
T22428 10985-10989 NN denotes B-1a
T22429 10990-10999 NN denotes phenotype
T22430 10999-11000 , denotes ,
T22431 11001-11003 IN denotes of
T22432 11004-11009 WDT denotes which
T22433 11010-11019 VBZ denotes lymphomas
T22434 11020-11021 CD denotes 2
T22435 11022-11025 CC denotes and
T22436 11026-11027 CD denotes 4
T22437 11028-11032 VBD denotes were
T22438 11033-11037 RB denotes also
T22439 11038-11044 RB denotes doubly
T22440 11045-11053 JJ denotes positive
T22441 11054-11057 IN denotes for
T22442 11058-11059 NN denotes κ
T22443 11060-11063 CC denotes and
T22444 11064-11065 NN denotes λ
T22445 11066-11071 NN denotes light
T22446 11072-11078 NNS denotes chains
T22447 11078-11079 . denotes .
T22448 11080-11081 -LRB- denotes (
T22449 11081-11082 NNP denotes B
T22450 11082-11083 -RRB- denotes )
T22451 11084-11088 NNP denotes Flow
T22452 11089-11098 NN denotes cytometry
T22453 11099-11107 NN denotes analysis
T22454 11108-11110 IN denotes of
T22455 11111-11113 NNP denotes WT
T22456 11114-11116 CC denotes or
T22457 11117-11121 NNP denotes LMP1
T22458 11122-11132 JJ denotes transgenic
T22459 11133-11144 NNS denotes splenocytes
T22460 11145-11148 IN denotes for
T22461 11149-11153 NN denotes B-1a
T22462 11154-11155 -LRB- denotes (
T22463 11155-11159 CD denotes CD19
T22464 11159-11160 NN denotes +
T22465 11160-11163 CD denotes CD5
T22466 11163-11164 NN denotes +
T22467 11164-11165 -RRB- denotes )
T22468 11166-11169 CC denotes and
T22469 11170-11174 JJ denotes B-1b
T22470 11175-11177 CC denotes or
T22471 11178-11180 JJ denotes B2
T22472 11181-11188 NNS denotes subsets
T22473 11189-11190 -LRB- denotes (
T22474 11190-11194 CD denotes CD19
T22475 11194-11195 NN denotes +
T22476 11195-11198 CD denotes CD5
T22477 11198-11199 NN denotes −
T22478 11199-11200 -RRB- denotes )
T22479 11200-11201 . denotes .
T22480 11202-11213 NNS denotes Percentages
T22481 11214-11216 IN denotes of
T22482 11217-11221 NN denotes B-1a
T22483 11222-11225 CC denotes and
T22484 11226-11230 NN denotes B-1b
T22485 11231-11233 CC denotes or
T22486 11234-11236 NN denotes B2
T22487 11237-11244 NNS denotes subsets
T22488 11245-11248 VBP denotes are
T22489 11249-11254 VBN denotes shown
T22490 11255-11257 IN denotes in
T22491 11258-11262 DT denotes each
T22492 11263-11271 NN denotes quadrant
T22493 11271-11272 . denotes .
T22494 11273-11277 DT denotes This
T22495 11278-11286 NN denotes analysis
T22496 11287-11290 VBD denotes was
T22497 11291-11299 VBN denotes repeated
T22498 11300-11302 IN denotes on
T22499 11303-11308 CD denotes three
T22500 11309-11314 JJ denotes other
T22501 11315-11317 NNP denotes WT
T22502 11318-11321 CC denotes and
T22503 11322-11325 CD denotes two
T22504 11326-11331 JJ denotes other
T22505 11332-11336 NNP denotes LMP1
T22506 11337-11347 NN denotes transgenic
T22507 11348-11352 NNS denotes mice
T22508 11353-11357 IN denotes with
T22509 11358-11365 JJ denotes similar
T22510 11366-11373 NNS denotes results
T22511 11373-11374 . denotes .
T22512 11375-11376 -LRB- denotes (
T22513 11376-11377 NNP denotes C
T22514 11377-11378 -RRB- denotes )
T22515 11379-11389 NNP denotes Immunoblot
T22516 11390-11398 NN denotes analysis
T22517 11399-11402 IN denotes for
T22518 11403-11404 NN denotes κ
T22519 11405-11408 CC denotes and
T22520 11409-11410 NN denotes λ
T22521 11411-11416 NN denotes light
T22522 11417-11423 NNS denotes chains
T22523 11424-11426 IN denotes of
T22524 11427-11428 NNP denotes B
T22525 11429-11434 NNS denotes cells
T22526 11435-11436 -LRB- denotes (
T22527 11436-11440 CD denotes CD19
T22528 11440-11441 NN denotes +
T22529 11441-11442 -RRB- denotes )
T22530 11443-11451 VBN denotes purified
T22531 11452-11456 IN denotes from
T22532 11457-11459 NNP denotes WT
T22533 11460-11463 CC denotes and
T22534 11464-11468 NNP denotes LMP1
T22535 11469-11479 JJ denotes transgenic
T22536 11480-11484 NNS denotes mice
T22537 11484-11485 . denotes .
T22538 11486-11491 NNP denotes Actin
T22539 11492-11495 VBD denotes was
T22540 11496-11500 VBN denotes used
T22541 11501-11503 IN denotes as
T22542 11504-11505 DT denotes a
T22543 11506-11513 VBG denotes loading
T22544 11514-11521 NN denotes control
T22545 11521-11522 . denotes .
T22851 14367-14371 CD denotes LMP1
T22852 14372-14380 NNP denotes Promotes
T22853 14381-14382 NNP denotes B
T22854 14383-14387 NNP denotes Cell
T22855 14388-14396 NNP denotes Survival
T22856 14397-14400 CC denotes and
T22857 14401-14414 NNP denotes Proliferation
T22858 14415-14417 IN denotes In
T22859 14418-14423 NNP denotes Vitro
T22860 14424-14425 -LRB- denotes (
T22861 14425-14426 NNP denotes A
T22862 14426-14427 -RRB- denotes )
T22863 14428-14431 NNP denotes MTS
T22864 14432-14437 NN denotes assay
T22865 14438-14440 IN denotes of
T22866 14441-14452 NNS denotes splenocytes
T22867 14453-14457 IN denotes from
T22868 14458-14460 NNP denotes WT
T22869 14461-14464 CC denotes and
T22870 14465-14469 NNP denotes LMP1
T22871 14470-14480 JJ denotes transgenic
T22872 14481-14485 NNS denotes mice
T22873 14485-14486 . denotes .
T22874 14487-14498 NNS denotes Splenocytes
T22875 14499-14503 VBD denotes were
T22876 14504-14512 VBN denotes cultured
T22877 14513-14515 IN denotes in
T22878 14516-14519 DT denotes the
T22879 14520-14528 NN denotes presence
T22880 14529-14530 -LRB- denotes (
T22881 14530-14534 NN denotes grey
T22882 14535-14539 NNS denotes bars
T22883 14539-14540 -RRB- denotes )
T22884 14541-14543 CC denotes or
T22885 14544-14551 NN denotes absence
T22886 14552-14553 -LRB- denotes (
T22887 14553-14558 JJ denotes black
T22888 14559-14563 NNS denotes bars
T22889 14563-14564 -RRB- denotes )
T22890 14565-14567 IN denotes of
T22891 14568-14571 NNP denotes IL4
T22892 14572-14575 IN denotes for
T22893 14576-14577 CD denotes 3
T22894 14578-14579 LS denotes d
T22895 14579-14580 . denotes .
T22896 14581-14584 DT denotes The
T22897 14585-14592 NNS denotes results
T22898 14593-14596 VBP denotes are
T22899 14597-14600 DT denotes the
T22900 14601-14605 JJ denotes mean
T22901 14606-14607 NN denotes ±
T22902 14608-14611 NNP denotes SEM
T22903 14612-14614 IN denotes of
T22904 14615-14625 NN denotes triplicate
T22905 14626-14633 NNS denotes samples
T22906 14634-14642 VBD denotes averaged
T22907 14643-14647 IN denotes from
T22908 14648-14656 JJ denotes multiple
T22909 14657-14661 NNS denotes mice
T22910 14662-14667 WRB denotes where
T22911 14669-14670 FW denotes n
T22912 14672-14675 DT denotes the
T22913 14676-14682 NN denotes number
T22914 14683-14685 IN denotes of
T22915 14686-14690 NNS denotes mice
T22916 14691-14699 VBD denotes analyzed
T22917 14700-14702 VBZ denotes is
T22918 14703-14705 IN denotes as
T22919 14706-14713 VBZ denotes follows
T22920 14713-14714 : denotes :
T22921 14715-14716 VB denotes n
T22922 14717-14718 SYM denotes =
T22923 14719-14720 CD denotes 2
T22924 14721-14724 IN denotes for
T22925 14725-14727 NNP denotes WT
T22926 14728-14739 NNS denotes lymphocytes
T22927 14740-14743 CC denotes and
T22928 14744-14746 NNP denotes WT
T22929 14747-14756 NNS denotes lymphomas
T22930 14756-14757 , denotes ,
T22931 14758-14759 VBP denotes n
T22932 14760-14761 SYM denotes =
T22933 14762-14764 CD denotes 11
T22934 14765-14768 IN denotes for
T22935 14769-14773 CD denotes LMP1
T22936 14774-14784 JJ denotes transgenic
T22937 14785-14796 NNS denotes lymphocytes
T22938 14796-14797 , denotes ,
T22939 14798-14801 CC denotes and
T22940 14802-14803 JJ denotes n
T22941 14804-14805 SYM denotes =
T22942 14806-14808 CD denotes 13
T22943 14809-14812 IN denotes for
T22944 14813-14817 CD denotes LMP1
T22945 14818-14828 JJ denotes transgenic
T22946 14829-14838 NNS denotes lymphomas
T22947 14838-14839 . denotes .
T22948 14840-14841 -LRB- denotes (
T22949 14841-14842 NNP denotes B
T22950 14842-14843 -RRB- denotes )
T22951 14844-14847 NNP denotes EMA
T22952 14848-14857 NN denotes exclusion
T22953 14858-14860 IN denotes of
T22954 14861-14865 NNP denotes CD19
T22955 14865-14866 NNP denotes +
T22956 14867-14872 VBD denotes gated
T22957 14873-14884 NNS denotes splenocytes
T22958 14885-14889 IN denotes from
T22959 14890-14892 NNP denotes WT
T22960 14893-14896 CC denotes and
T22961 14897-14901 NNP denotes LMP1
T22962 14902-14912 JJ denotes transgenic
T22963 14913-14917 NNS denotes mice
T22964 14918-14925 VBG denotes showing
T22965 14926-14936 NN denotes percentage
T22966 14937-14939 IN denotes of
T22967 14940-14946 JJ denotes viable
T22968 14947-14948 NNP denotes B
T22969 14949-14954 NNS denotes cells
T22970 14955-14963 VBD denotes cultured
T22971 14964-14968 IN denotes with
T22972 14969-14970 -LRB- denotes (
T22973 14970-14975 JJ denotes white
T22974 14976-14980 NNS denotes bars
T22975 14980-14981 -RRB- denotes )
T22976 14982-14984 CC denotes or
T22977 14985-14992 IN denotes without
T22978 14993-14994 -LRB- denotes (
T22979 14994-14999 JJ denotes black
T22980 15000-15004 NNS denotes bars
T22981 15004-15005 -RRB- denotes )
T22982 15006-15009 CD denotes IL4
T22983 15010-15013 IN denotes for
T22984 15014-15015 CD denotes 2
T22985 15016-15018 NN denotes d.
T22986 15019-15020 -LRB- denotes (
T22987 15020-15021 NNP denotes C
T22988 15021-15022 -RRB- denotes )
T22989 15023-15027 NNP denotes Flow
T22990 15028-15037 NN denotes cytometry
T22991 15038-15046 NN denotes analysis
T22992 15047-15050 IN denotes for
T22993 15051-15063 JJ denotes incorporated
T22994 15064-15068 NNP denotes BrdU
T22995 15069-15071 IN denotes in
T22996 15072-15074 NNP denotes WT
T22997 15075-15078 CC denotes and
T22998 15079-15083 NNP denotes LMP1
T22999 15084-15094 JJ denotes transgenic
T23000 15095-15103 NN denotes lymphoma
T23001 15104-15109 NNS denotes cells
T23002 15110-15118 VBN denotes cultured
T23003 15119-15123 IN denotes with
T23004 15124-15126 CC denotes or
T23005 15127-15134 IN denotes without
T23006 15135-15138 NNP denotes IL4
T23007 15139-15142 IN denotes for
T23008 15143-15144 CD denotes 2
T23009 15145-15147 NN denotes d.
T23010 15148-15153 VBN denotes Shown
T23011 15154-15157 VBP denotes are
T23012 15158-15161 DT denotes the
T23013 15162-15169 NNS denotes results
T23014 15170-15174 IN denotes from
T23015 15175-15177 NNP denotes WT
T23016 15178-15186 NN denotes lymphoma
T23017 15187-15188 CD denotes 1
T23018 15189-15192 CC denotes and
T23019 15193-15197 CD denotes LMP1
T23020 15198-15208 JJ denotes transgenic
T23021 15209-15217 NN denotes lymphoma
T23022 15218-15219 CD denotes 2
T23023 15219-15220 . denotes .
T23024 15221-15232 NNS denotes Percentages
T23025 15233-15235 IN denotes of
T23026 15236-15241 NNS denotes cells
T23027 15242-15244 IN denotes in
T23028 15245-15249 DT denotes each
T23029 15250-15258 NN denotes quadrant
T23030 15259-15262 VBP denotes are
T23031 15263-15268 VBN denotes shown
T23032 15268-15269 . denotes .
T23362 17941-17950 NNP denotes Wild-Type
T23363 17951-17954 CC denotes and
T23364 17955-17959 NNP denotes LMP1
T23365 17960-17970 NNP denotes Transgenic
T23366 17971-17979 NNP denotes Lymphoma
T23367 17980-17985 NNP denotes Cells
T23368 17986-17993 VB denotes Survive
T23369 17994-18007 RB denotes Independently
T23370 18008-18010 IN denotes of
T23371 18011-18020 NNP denotes IL4/Stat6
T23372 18021-18030 NNP denotes Signaling
T23373 18031-18033 IN denotes in
T23374 18034-18041 NNP denotes Culture
T23375 18042-18043 -LRB- denotes (
T23376 18043-18044 NNP denotes A
T23377 18044-18045 -RRB- denotes )
T23378 18046-18051 NNP denotes Rnase
T23379 18052-18062 NN denotes protection
T23380 18063-18068 NN denotes assay
T23381 18069-18072 IN denotes for
T23382 18073-18076 NNP denotes IL4
T23383 18077-18081 NNP denotes mRNA
T23384 18082-18086 IN denotes from
T23385 18087-18095 VBN denotes purified
T23386 18096-18097 NNP denotes B
T23387 18098-18103 NNS denotes cells
T23388 18104-18105 -LRB- denotes (
T23389 18105-18109 CD denotes CD19
T23390 18109-18110 NN denotes +
T23391 18110-18111 -RRB- denotes )
T23392 18112-18116 IN denotes from
T23393 18117-18119 NNP denotes WT
T23394 18120-18123 CC denotes and
T23395 18124-18128 NNP denotes LMP1
T23396 18129-18139 JJ denotes transgenic
T23397 18140-18151 NNS denotes splenocytes
T23398 18151-18152 . denotes .
T23399 18153-18156 DT denotes The
T23400 18157-18160 NNP denotes L32
T23401 18161-18164 CC denotes and
T23402 18165-18170 NNP denotes GAPDH
T23403 18171-18183 NN denotes housekeeping
T23404 18184-18189 NNS denotes genes
T23405 18190-18194 VBD denotes were
T23406 18195-18199 VBN denotes used
T23407 18200-18202 IN denotes as
T23408 18203-18204 DT denotes a
T23409 18205-18212 VBG denotes loading
T23410 18213-18220 NN denotes control
T23411 18220-18221 . denotes .
T23412 18222-18227 NNP denotes Arrow
T23413 18228-18237 VBZ denotes indicates
T23414 18238-18241 DT denotes the
T23415 18242-18250 NN denotes position
T23416 18251-18253 IN denotes of
T23417 18254-18257 DT denotes the
T23418 18258-18267 JJ denotes protected
T23419 18268-18273 NN denotes probe
T23420 18273-18274 . denotes .
T23421 18275-18276 -LRB- denotes (
T23422 18276-18277 NNP denotes B
T23423 18278-18281 CC denotes and
T23424 18282-18283 NNP denotes C
T23425 18283-18284 -RRB- denotes )
T23426 18285-18295 NNP denotes Immunoblot
T23427 18296-18304 NN denotes analysis
T23428 18305-18307 IN denotes of
T23429 18308-18310 NNP denotes WT
T23430 18311-18314 CC denotes and
T23431 18315-18319 NNP denotes LMP1
T23432 18320-18330 JJ denotes transgenic
T23433 18331-18335 NNS denotes mice
T23434 18336-18339 IN denotes for
T23435 18340-18349 VBN denotes activated
T23436 18350-18356 NNP denotes pStat6
T23437 18357-18359 IN denotes in
T23438 18360-18361 -LRB- denotes (
T23439 18361-18362 NNP denotes B
T23440 18362-18363 -RRB- denotes )
T23441 18364-18372 VBD denotes purified
T23442 18373-18374 NNP denotes B
T23443 18375-18380 NNS denotes cells
T23444 18381-18382 -LRB- denotes (
T23445 18382-18386 CD denotes CD19
T23446 18386-18387 NN denotes +
T23447 18387-18388 -RRB- denotes )
T23448 18389-18391 IN denotes at
T23449 18392-18395 DT denotes the
T23450 18396-18400 NN denotes time
T23451 18401-18403 IN denotes of
T23452 18404-18411 NN denotes harvest
T23453 18412-18414 CC denotes or
T23454 18415-18417 IN denotes in
T23455 18418-18419 -LRB- denotes (
T23456 18419-18420 NNP denotes C
T23457 18420-18421 -RRB- denotes )
T23458 18422-18427 JJ denotes whole
T23459 18428-18439 NNS denotes splenocytes
T23460 18440-18448 VBN denotes cultured
T23461 18449-18453 IN denotes with
T23462 18454-18456 CC denotes or
T23463 18457-18464 IN denotes without
T23464 18465-18468 NNP denotes IL4
T23465 18468-18469 . denotes .
T23466 18470-18471 -LRB- denotes (
T23467 18471-18472 NNP denotes B
T23468 18472-18473 -RRB- denotes )
T23469 18474-18479 NNP denotes Actin
T23470 18480-18483 VBD denotes was
T23471 18484-18488 VBN denotes used
T23472 18489-18491 IN denotes as
T23473 18492-18493 DT denotes a
T23474 18494-18501 VBG denotes loading
T23475 18502-18509 NN denotes control
T23476 18509-18510 , denotes ,
T23477 18511-18514 CC denotes and
T23478 18515-18518 DT denotes the
T23479 18519-18524 JJ denotes white
T23480 18525-18529 NN denotes line
T23481 18530-18539 VBZ denotes indicates
T23482 18540-18544 IN denotes that
T23483 18545-18556 VBG denotes intervening
T23484 18557-18562 NNS denotes lanes
T23485 18563-18567 VBP denotes have
T23486 18568-18572 VBN denotes been
T23487 18573-18580 VBN denotes spliced
T23488 18581-18584 RP denotes out
T23489 18584-18585 . denotes .
T23490 18586-18587 -LRB- denotes (
T23491 18587-18588 NNP denotes D
T23492 18589-18592 CC denotes and
T23493 18593-18594 NNP denotes E
T23494 18594-18595 -RRB- denotes )
T23495 18596-18599 NNP denotes MTS
T23496 18600-18605 NN denotes assay
T23497 18606-18608 IN denotes of
T23498 18609-18610 -LRB- denotes (
T23499 18610-18611 NNP denotes D
T23500 18611-18612 -RRB- denotes )
T23501 18613-18615 NNP denotes WT
T23502 18616-18627 NNS denotes lymphocytes
T23503 18628-18631 CC denotes and
T23504 18632-18633 -LRB- denotes (
T23505 18633-18634 NNP denotes E
T23506 18634-18635 -RRB- denotes )
T23507 18636-18640 CD denotes LMP1
T23508 18641-18651 JJ denotes transgenic
T23509 18652-18660 NN denotes lymphoma
T23510 18661-18666 NNS denotes cells
T23511 18667-18675 VBN denotes cultured
T23512 18676-18680 IN denotes with
T23513 18681-18684 NNP denotes IL4
T23514 18684-18685 , denotes ,
T23515 18686-18687 DT denotes a
T23516 18688-18700 VBG denotes neutralizing
T23517 18701-18709 NN denotes antibody
T23518 18710-18712 TO denotes to
T23519 18713-18716 NNP denotes IL4
T23520 18716-18717 , denotes ,
T23521 18718-18720 CC denotes or
T23522 18721-18722 DT denotes a
T23523 18723-18726 NN denotes rat
T23524 18727-18730 NNP denotes IgG
T23525 18731-18738 NN denotes isotype
T23526 18739-18746 NN denotes control
T23527 18747-18749 IN denotes at
T23528 18750-18753 DT denotes the
T23529 18754-18763 VBN denotes indicated
T23530 18764-18778 NNS denotes concentrations
T23531 18778-18779 . denotes .
T23532 18780-18785 VBN denotes Shown
T23533 18786-18789 VBP denotes are
T23534 18790-18793 DT denotes the
T23535 18794-18801 NNS denotes results
T23536 18802-18806 IN denotes from
T23537 18807-18811 CD denotes LMP1
T23538 18812-18822 JJ denotes transgenic
T23539 18823-18831 NN denotes lymphoma
T23540 18832-18833 CD denotes 3
T23541 18833-18834 . denotes .
T23542 18835-18838 DT denotes The
T23543 18839-18846 NNS denotes results
T23544 18847-18850 VBP denotes are
T23545 18851-18854 DT denotes the
T23546 18855-18859 JJ denotes mean
T23547 18860-18861 NN denotes ±
T23548 18862-18865 NNP denotes SEM
T23549 18866-18868 IN denotes of
T23550 18869-18879 NN denotes triplicate
T23551 18880-18887 NNS denotes samples
T23552 18888-18892 IN denotes from
T23553 18893-18894 DT denotes a
T23554 18895-18901 JJ denotes single
T23555 18902-18916 NN denotes representative
T23556 18917-18927 NN denotes experiment
T23557 18928-18932 WDT denotes that
T23558 18933-18936 VBD denotes was
T23559 18937-18945 VBN denotes repeated
T23560 18946-18951 RB denotes twice
T23561 18952-18956 IN denotes with
T23562 18957-18964 JJ denotes similar
T23563 18965-18972 NNS denotes results
T23564 18972-18973 . denotes .
T23961 22890-22894 CD denotes LMP1
T23962 22895-22906 NNPS denotes Upregulates
T23963 22907-22911 NNP denotes IL10
T23964 22912-22922 NNP denotes Expression
T23965 22923-22926 CC denotes and
T23966 22927-22941 NNP denotes Constitutively
T23967 22942-22951 NNP denotes Activates
T23968 22952-22957 NNP denotes Stat3
T23969 22958-22959 -LRB- denotes (
T23970 22959-22960 NNP denotes A
T23971 22960-22961 -RRB- denotes )
T23972 22962-22970 JJ denotes Relative
T23973 22971-22981 NN denotes expression
T23974 22982-22984 IN denotes of
T23975 22985-22989 NNP denotes IL10
T23976 22989-22990 , denotes ,
T23977 22991-22995 NNP denotes IL15
T23978 22995-22996 , denotes ,
T23979 22997-23000 CC denotes and
T23980 23001-23005 NNP denotes IFNγ
T23981 23006-23010 NNP denotes mRNA
T23982 23011-23013 IN denotes in
T23983 23014-23016 NNP denotes WT
T23984 23017-23020 CC denotes and
T23985 23021-23025 NNP denotes LMP1
T23986 23026-23036 JJ denotes transgenic
T23987 23037-23038 NNP denotes B
T23988 23039-23044 NNS denotes cells
T23989 23045-23046 -LRB- denotes (
T23990 23046-23050 CD denotes CD19
T23991 23050-23051 NN denotes +
T23992 23051-23052 -RRB- denotes )
T23993 23052-23053 , denotes ,
T23994 23054-23056 IN denotes as
T23995 23057-23065 VBN denotes detected
T23996 23066-23070 IN denotes with
T23997 23071-23073 DT denotes an
T23998 23074-23079 JJ denotes Rnase
T23999 23080-23090 NN denotes protection
T24000 23091-23096 NN denotes assay
T24001 23096-23097 . denotes .
T24002 23098-23103 NNP denotes Mouse
T24003 23104-23112 NN denotes lymphoma
T24004 23113-23117 NN denotes cell
T24005 23118-23123 NNS denotes lines
T24006 23124-23127 CD denotes 967
T24007 23128-23131 CC denotes and
T24008 23132-23136 NNP denotes K46μ
T24009 23137-23141 VBD denotes were
T24010 23142-23146 VBN denotes used
T24011 23147-23149 IN denotes as
T24012 23150-23158 NNS denotes controls
T24013 23158-23159 . denotes .
T24014 23160-23170 NN denotes Expression
T24015 23171-23177 NNS denotes levels
T24016 23178-23182 VBD denotes were
T24017 23183-23193 VBN denotes quantified
T24018 23194-23198 IN denotes with
T24019 23199-23200 DT denotes a
T24020 23201-23215 NN denotes phosphorimager
T24021 23216-23219 CC denotes and
T24022 23220-23226 NNS denotes values
T24023 23227-23231 VBD denotes were
T24024 23232-23242 VBN denotes normalized
T24025 23243-23245 TO denotes to
T24026 23246-23249 DT denotes the
T24027 23250-23259 JJ denotes ribosomal
T24028 23260-23272 NN denotes housekeeping
T24029 23273-23277 NN denotes gene
T24030 23278-23281 NNP denotes L32
T24031 23281-23282 . denotes .
T24032 23283-23286 DT denotes The
T24033 23287-23295 NN denotes cytokine
T24034 23295-23296 : denotes :
T24035 23296-23299 CD denotes L32
T24036 23300-23305 NN denotes ratio
T24037 23306-23309 VBD denotes was
T24038 23310-23313 VBN denotes set
T24039 23314-23316 TO denotes to
T24040 23317-23318 CD denotes 1
T24041 23319-23321 IN denotes in
T24042 23322-23325 DT denotes the
T24043 23326-23331 NN denotes mouse
T24044 23332-23333 NNP denotes B
T24045 23334-23338 NN denotes cell
T24046 23339-23347 NN denotes lymphoma
T24047 23348-23352 NN denotes line
T24048 23353-23356 CD denotes 967
T24049 23356-23357 . denotes .
T24050 23358-23359 -LRB- denotes (
T24051 23359-23360 NNP denotes B
T24052 23361-23364 CC denotes and
T24053 23365-23366 NNP denotes C
T24054 23366-23367 -RRB- denotes )
T24055 23368-23378 NNP denotes Immunoblot
T24056 23379-23387 NN denotes analysis
T24057 23388-23390 IN denotes of
T24058 23391-23400 VBN denotes activated
T24059 23401-23407 NNP denotes pStat3
T24060 23408-23410 IN denotes in
T24061 23411-23419 JJ denotes purified
T24062 23420-23421 NNP denotes B
T24063 23422-23427 NNS denotes cells
T24064 23428-23429 -LRB- denotes (
T24065 23429-23433 CD denotes CD19
T24066 23433-23434 NN denotes +
T24067 23434-23435 -RRB- denotes )
T24068 23436-23440 IN denotes from
T24069 23441-23443 NNP denotes WT
T24070 23444-23447 CC denotes and
T24071 23448-23452 NNP denotes LMP1
T24072 23453-23463 JJ denotes transgenic
T24073 23464-23468 NNS denotes mice
T24074 23469-23470 -LRB- denotes (
T24075 23470-23471 NNP denotes B
T24076 23471-23472 -RRB- denotes )
T24077 23473-23475 IN denotes at
T24078 23476-23479 DT denotes the
T24079 23480-23484 NN denotes time
T24080 23485-23487 IN denotes of
T24081 23488-23495 NN denotes harvest
T24082 23495-23496 , denotes ,
T24083 23497-23500 CC denotes and
T24084 23501-23502 -LRB- denotes (
T24085 23502-23503 NNP denotes C
T24086 23503-23504 -RRB- denotes )
T24087 23505-23506 CD denotes 4
T24088 23507-23508 NN denotes h
T24089 23509-23514 IN denotes after
T24090 23515-23522 NN denotes culture
T24091 23523-23527 IN denotes with
T24092 23528-23530 CC denotes or
T24093 23531-23538 IN denotes without
T24094 23539-23543 NNP denotes IL10
T24095 23543-23544 , denotes ,
T24096 23545-23546 DT denotes a
T24097 23547-23559 VBG denotes neutralizing
T24098 23560-23568 NN denotes antibody
T24099 23569-23571 TO denotes to
T24100 23572-23576 NNP denotes IL10
T24101 23576-23577 , denotes ,
T24102 23578-23580 CC denotes or
T24103 23581-23582 DT denotes a
T24104 23583-23586 NN denotes rat
T24105 23587-23591 JJ denotes IgG1
T24106 23592-23599 NN denotes isotype
T24107 23600-23607 NN denotes control
T24108 23607-23608 . denotes .
T24109 23609-23610 -LRB- denotes (
T24110 23610-23611 $ denotes C
T24111 23611-23612 -RRB- denotes )
T24112 23613-23618 VBN denotes Shown
T24113 23619-23622 VBP denotes are
T24114 23623-23626 DT denotes the
T24115 23627-23634 NNS denotes results
T24116 23635-23638 IN denotes for
T24117 23639-23641 NNP denotes WT
T24118 23642-23650 NN denotes lymphoma
T24119 23651-23652 CD denotes 1
T24120 23653-23656 CC denotes and
T24121 23657-23661 CD denotes LMP1
T24122 23662-23672 JJ denotes transgenic
T24123 23673-23681 NN denotes lymphoma
T24124 23682-23683 CD denotes 1
T24125 23683-23684 . denotes .
T24126 23685-23691 NNS denotes Arrows
T24127 23692-23700 VBP denotes indicate
T24128 23701-23704 DT denotes the
T24129 23705-23714 NNS denotes positions
T24130 23715-23717 IN denotes of
T24131 23718-23721 DT denotes the
T24132 23722-23723 NN denotes α
T24133 23724-23727 CC denotes and
T24134 23728-23729 NN denotes β
T24135 23730-23738 NNS denotes isoforms
T24136 23739-23741 IN denotes of
T24137 23742-23747 NNP denotes Stat3
T24138 23747-23748 . denotes .
T24139 23749-23754 NNP denotes Actin
T24140 23755-23758 VBD denotes was
T24141 23759-23763 VBN denotes used
T24142 23764-23766 IN denotes as
T24143 23767-23768 DT denotes a
T24144 23769-23776 VBG denotes loading
T24145 23777-23784 NN denotes control
T24146 23784-23785 . denotes .
T24147 23786-23787 -LRB- denotes (
T24148 23787-23788 NNP denotes D
T24149 23788-23789 -RRB- denotes )
T24150 23790-23810 NNP denotes Immunohistochemistry
T24151 23811-23820 NN denotes detection
T24152 23821-23823 IN denotes of
T24153 23824-23833 VBN denotes activated
T24154 23834-23841 JJ denotes nuclear
T24155 23842-23848 NN denotes pStat3
T24156 23849-23851 IN denotes in
T24157 23852-23855 DT denotes the
T24158 23856-23863 NNS denotes spleens
T24159 23864-23866 IN denotes of
T24160 23867-23869 NNP denotes WT
T24161 23870-23873 CC denotes and
T24162 23874-23878 NNP denotes LMP1
T24163 23879-23889 JJ denotes transgenic
T24164 23890-23894 NNS denotes mice
T24165 23894-23895 . denotes .
T24166 23896-23901 NNP denotes Scale
T24167 23902-23905 NN denotes bar
T24168 23905-23906 , denotes ,
T24169 23907-23909 CD denotes 20
T24170 23910-23912 NN denotes μm
T24171 23912-23913 . denotes .
T24520 25723-25727 CD denotes LMP1
T24521 25728-25737 NNP denotes Activates
T24522 25738-25741 NNP denotes Akt
T24523 25742-25751 VBG denotes Signaling
T24524 25752-25755 CC denotes and
T24525 25756-25767 VBZ denotes Deregulates
T24526 25768-25771 DT denotes the
T24527 25772-25774 NNP denotes Rb
T24528 25775-25779 NNP denotes Cell
T24529 25780-25785 NNP denotes Cycle
T24530 25786-25793 NNP denotes Pathway
T24531 25794-25795 -LRB- denotes (
T24532 25795-25796 DT denotes A
T24533 25797-25800 CC denotes and
T24534 25801-25802 NNP denotes B
T24535 25802-25803 -RRB- denotes )
T24536 25804-25814 NNP denotes Immunoblot
T24537 25815-25823 NN denotes analysis
T24538 25824-25826 IN denotes of
T24539 25827-25835 VBN denotes purified
T24540 25836-25837 NNP denotes B
T24541 25838-25843 NNS denotes cells
T24542 25844-25845 -LRB- denotes (
T24543 25845-25849 CD denotes CD19
T24544 25849-25850 NN denotes +
T24545 25850-25851 -RRB- denotes )
T24546 25852-25856 IN denotes from
T24547 25857-25860 DT denotes the
T24548 25861-25868 NNS denotes spleens
T24549 25869-25871 IN denotes of
T24550 25872-25874 NNP denotes WT
T24551 25875-25878 CC denotes and
T24552 25879-25883 NNP denotes LMP1
T24553 25884-25894 JJ denotes transgenic
T24554 25895-25899 NNS denotes mice
T24555 25900-25903 IN denotes for
T24556 25904-25907 NNP denotes Akt
T24557 25908-25917 VBG denotes signaling
T24558 25917-25918 , denotes ,
T24559 25919-25926 VBG denotes probing
T24560 25927-25930 IN denotes for
T24561 25931-25932 -LRB- denotes (
T24562 25932-25933 NN denotes A
T24563 25933-25934 -RRB- denotes )
T24564 25935-25944 VBN denotes activated
T24565 25945-25949 NNP denotes pAkt
T24566 25950-25953 CC denotes and
T24567 25954-25964 JJ denotes downstream
T24568 25965-25972 NNS denotes targets
T24569 25972-25973 , denotes ,
T24570 25974-25983 VBG denotes including
T24571 25984-25995 JJ denotes inactivated
T24572 25996-26002 JJ denotes pGSK3α
T24573 26002-26003 NN denotes /
T24574 26003-26004 NN denotes β
T24575 26004-26005 , denotes ,
T24576 26006-26009 CC denotes and
T24577 26010-26011 -LRB- denotes (
T24578 26011-26012 NNP denotes B
T24579 26012-26013 -RRB- denotes )
T24580 26014-26023 VBD denotes activated
T24581 26024-26030 NNP denotes p-mTOR
T24582 26030-26031 , denotes ,
T24583 26032-26035 CC denotes and
T24584 26036-26041 JJ denotes total
T24585 26042-26048 NNS denotes levels
T24586 26049-26051 IN denotes of
T24587 26052-26057 NNP denotes FoxO1
T24588 26057-26058 . denotes .
T24589 26059-26065 NNS denotes Arrows
T24590 26066-26074 VBP denotes indicate
T24591 26075-26078 DT denotes the
T24592 26079-26088 NNS denotes positions
T24593 26089-26091 IN denotes of
T24594 26092-26093 NN denotes α
T24595 26094-26097 CC denotes and
T24596 26098-26099 NN denotes β
T24597 26100-26108 NNS denotes isoforms
T24598 26109-26111 IN denotes of
T24599 26112-26116 NNP denotes GSK3
T24600 26116-26117 . denotes .
T24601 26118-26121 DT denotes The
T24602 26122-26127 JJ denotes white
T24603 26128-26132 NN denotes line
T24604 26133-26142 VBZ denotes indicates
T24605 26143-26147 IN denotes that
T24606 26148-26159 VBG denotes intervening
T24607 26160-26165 NNS denotes lanes
T24608 26166-26170 VBP denotes have
T24609 26171-26175 VBN denotes been
T24610 26176-26183 VBN denotes spliced
T24611 26184-26187 RP denotes out
T24612 26187-26188 . denotes .
T24613 26189-26190 -LRB- denotes (
T24614 26190-26191 NNP denotes C
T24615 26191-26192 -RRB- denotes )
T24616 26193-26203 NNP denotes Immunoblot
T24617 26204-26212 NN denotes analysis
T24618 26213-26216 IN denotes for
T24619 26217-26221 NN denotes cell
T24620 26222-26227 NN denotes cycle
T24621 26228-26236 NNS denotes proteins
T24622 26237-26247 VBG denotes regulating
T24623 26248-26251 DT denotes the
T24624 26252-26254 NNP denotes Rb
T24625 26255-26262 NN denotes pathway
T24626 26262-26263 , denotes ,
T24627 26264-26271 VBG denotes probing
T24628 26272-26275 IN denotes for
T24629 26276-26285 VBN denotes activated
T24630 26286-26289 NNP denotes pRb
T24631 26289-26290 , denotes ,
T24632 26291-26294 CC denotes and
T24633 26295-26300 JJ denotes total
T24634 26301-26307 NNS denotes levels
T24635 26308-26310 IN denotes of
T24636 26311-26315 NNP denotes Cdk2
T24637 26316-26319 CC denotes and
T24638 26320-26323 DT denotes the
T24639 26324-26327 NNP denotes Cdk
T24640 26328-26337 NN denotes inhibitor
T24641 26338-26341 NN denotes p27
T24642 26341-26342 . denotes .
T24643 26343-26348 NNP denotes Actin
T24644 26349-26352 VBD denotes was
T24645 26353-26357 VBN denotes used
T24646 26358-26360 IN denotes as
T24647 26361-26362 DT denotes a
T24648 26363-26370 VBG denotes loading
T24649 26371-26378 NN denotes control
T24650 26378-26379 . denotes .
T24974 30201-30204 NNP denotes Akt
T24975 30204-30205 , denotes ,
T24976 30206-30210 NNP denotes NFκB
T24977 30210-30211 , denotes ,
T24978 30212-30215 CC denotes and
T24979 30216-30221 NNP denotes Stat3
T24980 30222-30231 NNP denotes Signaling
T24981 30232-30235 VBP denotes Are
T24982 30236-30244 VBN denotes Required
T24983 30245-30248 IN denotes for
T24984 30249-30252 DT denotes the
T24985 30253-30259 NN denotes Growth
T24986 30260-30263 CC denotes and
T24987 30264-30272 NN denotes Survival
T24988 30273-30275 IN denotes of
T24989 30276-30284 NNP denotes Lymphoma
T24990 30285-30290 NNP denotes Cells
T24991 30291-30294 NNP denotes MTS
T24992 30295-30300 NN denotes assay
T24993 30301-30303 IN denotes of
T24994 30304-30315 NNS denotes splenocytes
T24995 30316-30320 IN denotes from
T24996 30321-30322 -LRB- denotes (
T24997 30322-30323 DT denotes A
T24998 30324-30327 CC denotes and
T24999 30328-30329 NNP denotes B
T25000 30329-30330 -RRB- denotes )
T25001 30331-30333 NNP denotes WT
T25002 30334-30336 CC denotes or
T25003 30337-30338 -LRB- denotes (
T25004 30338-30339 NNP denotes C
T25005 30340-30343 CC denotes and
T25006 30344-30345 NNP denotes D
T25007 30345-30346 -RRB- denotes )
T25008 30347-30351 CD denotes LMP1
T25009 30352-30362 JJ denotes transgenic
T25010 30363-30372 NNS denotes lymphomas
T25011 30373-30376 CC denotes and
T25012 30377-30378 -LRB- denotes (
T25013 30378-30379 NNP denotes E
T25014 30380-30383 CC denotes and
T25015 30384-30385 NN denotes F
T25016 30385-30386 -RRB- denotes )
T25017 30387-30391 CD denotes LMP1
T25018 30392-30402 JJ denotes transgenic
T25019 30403-30414 NNS denotes lymphoctyes
T25020 30414-30415 . denotes .
T25021 30416-30427 NNS denotes Splenocytes
T25022 30428-30432 VBD denotes were
T25023 30433-30441 VBN denotes cultured
T25024 30442-30446 IN denotes with
T25025 30447-30449 CC denotes or
T25026 30450-30457 IN denotes without
T25027 30458-30468 NNS denotes inhibitors
T25028 30469-30471 IN denotes of
T25029 30472-30476 NNP denotes NFκB
T25030 30477-30478 -LRB- denotes (
T25031 30478-30483 NNP denotes BAY11
T25032 30483-30484 -RRB- denotes )
T25033 30484-30485 , denotes ,
T25034 30486-30490 NNP denotes mTOR
T25035 30491-30492 -LRB- denotes (
T25036 30492-30501 NN denotes rapamycin
T25037 30501-30502 -RRB- denotes )
T25038 30502-30503 , denotes ,
T25039 30504-30507 NNP denotes Akt
T25040 30508-30509 -LRB- denotes (
T25041 30509-30520 NN denotes triciribine
T25042 30520-30521 -RRB- denotes )
T25043 30521-30522 , denotes ,
T25044 30523-30529 NNP denotes MEK1/2
T25045 30530-30531 -LRB- denotes (
T25046 30531-30536 NNP denotes U0126
T25047 30536-30537 -RRB- denotes )
T25048 30537-30538 , denotes ,
T25049 30539-30542 JJ denotes p38
T25050 30543-30544 -LRB- denotes (
T25051 30544-30552 CD denotes SB202190
T25052 30552-30553 -RRB- denotes )
T25053 30553-30554 , denotes ,
T25054 30555-30557 CC denotes or
T25055 30558-30563 NNP denotes Stat3
T25056 30564-30565 -LRB- denotes (
T25057 30565-30577 NN denotes cucurbitacin
T25058 30578-30579 PRP denotes I
T25059 30580-30583 CC denotes and
T25060 30584-30589 NNP denotes AG490
T25061 30589-30590 -RRB- denotes )
T25062 30591-30593 IN denotes at
T25063 30594-30597 DT denotes the
T25064 30598-30607 VBN denotes indicated
T25065 30608-30622 NNS denotes concentrations
T25066 30622-30623 . denotes .
T25067 30624-30627 DT denotes The
T25068 30628-30635 NNS denotes results
T25069 30636-30639 VBP denotes are
T25070 30640-30643 DT denotes the
T25071 30644-30648 JJ denotes mean
T25072 30649-30650 NN denotes ±
T25073 30651-30654 NNP denotes SEM
T25074 30655-30657 IN denotes of
T25075 30658-30668 NN denotes triplicate
T25076 30669-30676 NNS denotes samples
T25077 30676-30677 . denotes .
T25078 30678-30683 VBN denotes Shown
T25079 30684-30687 VBP denotes are
T25080 30688-30691 DT denotes the
T25081 30692-30699 NNS denotes results
T25082 30700-30703 IN denotes for
T25083 30704-30705 -LRB- denotes (
T25084 30705-30706 DT denotes A
T25085 30707-30710 CC denotes and
T25086 30711-30712 NNP denotes B
T25087 30712-30713 -RRB- denotes )
T25088 30714-30716 NNP denotes WT
T25089 30717-30725 NN denotes lymphoma
T25090 30726-30727 CD denotes 1
T25091 30727-30728 , denotes ,
T25092 30729-30730 -LRB- denotes (
T25093 30730-30731 NNP denotes C
T25094 30732-30735 CC denotes and
T25095 30736-30737 NNP denotes D
T25096 30737-30738 -RRB- denotes )
T25097 30739-30743 CD denotes LMP1
T25098 30744-30754 JJ denotes transgenic
T25099 30755-30763 NN denotes lymphoma
T25100 30764-30765 CD denotes 2
T25101 30765-30766 , denotes ,
T25102 30767-30770 CC denotes and
T25103 30771-30772 -LRB- denotes (
T25104 30772-30773 NNP denotes E
T25105 30774-30777 CC denotes and
T25106 30778-30779 NN denotes F
T25107 30779-30780 -RRB- denotes )
T25108 30781-30784 CD denotes one
T25109 30785-30788 IN denotes out
T25110 30789-30791 IN denotes of
T25111 30792-30795 CD denotes two
T25112 30796-30800 CD denotes LMP1
T25113 30801-30811 JJ denotes transgenic
T25114 30812-30816 NNS denotes mice
T25115 30817-30825 VBD denotes analyzed
T25116 30825-30826 . denotes .
T25117 30827-30831 DT denotes This
T25118 30832-30840 NN denotes analysis
T25119 30841-30844 VBD denotes was
T25120 30845-30853 VBN denotes repeated
T25121 30854-30858 IN denotes with
T25122 30859-30863 CD denotes LMP1
T25123 30864-30874 JJ denotes transgenic
T25124 30875-30883 NN denotes lymphoma
T25125 30884-30885 CD denotes 4
T25126 30886-30894 VBG denotes yielding
T25127 30895-30902 JJ denotes similar
T25128 30903-30910 NNS denotes results
T25129 30910-30911 . denotes .
T25354 30922-30930 NN denotes Analysis
T25355 30931-30933 IN denotes of
T25356 30934-30937 NNP denotes Akt
T25357 30937-30938 , denotes ,
T25358 30939-30943 NNP denotes NFκB
T25359 30943-30944 , denotes ,
T25360 30945-30948 CC denotes and
T25361 30949-30954 NNP denotes Stat3
T25362 30955-30963 NNPS denotes Pathways
T25363 30964-30966 IN denotes in
T25364 30967-30979 NN denotes Contribution
T25365 30980-30982 TO denotes to
T25366 30983-30986 DT denotes the
T25367 30987-30993 NN denotes Growth
T25368 30994-30997 CC denotes and
T25369 30998-31006 NN denotes Survival
T25370 31007-31009 IN denotes of
T25371 31010-31018 NNP denotes Lymphoma
T25372 31019-31024 NNP denotes Cells
T25373 31025-31026 -LRB- denotes (
T25374 31026-31027 DT denotes A
T25375 31028-31029 NNP denotes D
T25376 31029-31030 -RRB- denotes )
T25377 31031-31041 NNP denotes Immunoblot
T25378 31042-31050 NN denotes analysis
T25379 31051-31053 IN denotes of
T25380 31054-31063 JJ denotes wild-type
T25381 31064-31067 CC denotes and
T25382 31068-31072 JJ denotes LMP1
T25383 31073-31083 JJ denotes transgenic
T25384 31084-31093 NNS denotes lymphomas
T25385 31094-31097 IN denotes for
T25386 31098-31101 NNP denotes Akt
T25387 31101-31102 , denotes ,
T25388 31103-31107 NNP denotes NFκB
T25389 31107-31108 , denotes ,
T25390 31109-31112 CC denotes and
T25391 31113-31118 JJ denotes Stat3
T25392 31119-31128 VBG denotes signaling
T25393 31129-31134 IN denotes after
T25394 31135-31144 NN denotes treatment
T25395 31145-31149 IN denotes with
T25396 31150-31151 -LRB- denotes (
T25397 31151-31152 NN denotes A
T25398 31152-31153 -RRB- denotes )
T25399 31154-31156 DT denotes an
T25400 31157-31160 NNP denotes Akt
T25401 31161-31170 NN denotes inhibitor
T25402 31170-31171 , denotes ,
T25403 31172-31183 NN denotes triciribine
T25404 31183-31184 , denotes ,
T25405 31185-31186 -LRB- denotes (
T25406 31186-31187 NNP denotes B
T25407 31187-31188 -RRB- denotes )
T25408 31189-31191 DT denotes an
T25409 31192-31196 NN denotes NFκB
T25410 31197-31206 NN denotes inhibitor
T25411 31206-31207 , denotes ,
T25412 31208-31213 NNP denotes BAY11
T25413 31214-31218 CD denotes 7085
T25414 31218-31219 , denotes ,
T25415 31220-31223 CC denotes and
T25416 31224-31227 DT denotes the
T25417 31228-31233 JJ denotes Stat3
T25418 31234-31244 NNS denotes inhibitors
T25419 31245-31246 -LRB- denotes (
T25420 31246-31247 NNP denotes C
T25421 31247-31248 -RRB- denotes )
T25422 31249-31261 NN denotes cucurbitacin
T25423 31262-31263 PRP denotes I
T25424 31264-31267 CC denotes and
T25425 31268-31269 -LRB- denotes (
T25426 31269-31270 NNP denotes D
T25427 31270-31271 -RRB- denotes )
T25428 31272-31277 NNP denotes AG490
T25429 31277-31278 , denotes ,
T25430 31279-31281 IN denotes at
T25431 31282-31285 DT denotes the
T25432 31286-31295 VBN denotes indicated
T25433 31296-31310 NNS denotes concentrations
T25434 31310-31311 . denotes .
T25435 31312-31318 NNS denotes Arrows
T25436 31319-31327 VBP denotes indicate
T25437 31328-31331 DT denotes the
T25438 31332-31341 NNS denotes positions
T25439 31342-31344 IN denotes of
T25440 31345-31346 NN denotes α
T25441 31347-31350 CC denotes and
T25442 31351-31352 NN denotes β
T25443 31353-31361 NNS denotes isoforms
T25444 31362-31364 IN denotes of
T25445 31365-31370 NNP denotes Stat3
T25446 31370-31371 . denotes .
T25447 31372-31377 NNP denotes Actin
T25448 31378-31381 VBD denotes was
T25449 31382-31386 VBN denotes used
T25450 31387-31389 IN denotes as
T25451 31390-31391 DT denotes a
T25452 31392-31399 VBG denotes loading
T21822 8531-8533 IN denotes of
T21823 8534-8542 NNP denotes Lymphoma
T21824 8543-8547 NNP denotes LMP1
T21825 8548-8558 NN denotes expression
T21826 8559-8561 VBZ denotes is
T21827 8562-8567 VBN denotes shown
T21828 8568-8570 IN denotes by
T21829 8571-8572 -LRB- denotes (
T21830 8572-8573 NN denotes A
T21831 8573-8574 -RRB- denotes )
T21832 8575-8589 NN denotes immunoblotting
T21833 8590-8592 IN denotes of
T21834 8593-8601 VBN denotes purified
T21835 8602-8603 NNP denotes B
T21836 8604-8609 NNS denotes cells
T21837 8610-8611 -LRB- denotes (
T21838 8611-8615 CD denotes CD19
T21839 8615-8616 NN denotes +
T21840 8616-8617 -RRB- denotes )
T21841 8618-8621 CC denotes and
T21842 8622-8623 -LRB- denotes (
T21843 8623-8624 NNP denotes B
T21844 8624-8625 -RRB- denotes )
T21845 8626-8646 NN denotes immunohistochemistry
T21846 8647-8655 NN denotes staining
T21847 8656-8658 IN denotes of
T21848 8659-8665 JJ denotes spleen
T21849 8666-8672 NN denotes tissue
T21850 8673-8677 IN denotes from
T21851 8678-8687 JJ denotes wild-type
T21852 8688-8689 -LRB- denotes (
T21853 8689-8691 NNP denotes WT
T21854 8691-8692 -RRB- denotes )
T21855 8693-8696 CC denotes and
T21856 8697-8701 CD denotes LMP1
T21886 8848-8849 DT denotes a
T21887 8850-8862 JJ denotes non-specific
T21888 8863-8867 NN denotes band
T21889 8867-8868 . denotes .
T21890 8869-8874 NNP denotes Actin
T21891 8875-8878 VBD denotes was
T21892 8879-8883 VBN denotes used
T21893 8884-8886 IN denotes as
T21894 8887-8888 DT denotes a
T21895 8889-8896 VBG denotes loading
T21896 8897-8904 NN denotes control
T21897 8904-8905 . denotes .
T21898 8906-8907 -LRB- denotes (
T21899 8907-8908 NNP denotes B
T21900 8908-8909 -RRB- denotes )
T21901 8910-8915 NNP denotes White
T21902 8916-8919 CC denotes and
T21903 8920-8923 JJ denotes red
T21904 8924-8929 NNS denotes pulps
T21905 8930-8933 VBP denotes are
T21906 8934-8939 VBN denotes shown
T21907 8939-8940 , denotes ,
T21908 8941-8944 CC denotes but
T21909 8945-8949 DT denotes this
T21910 8950-8962 NN denotes architecture
T21911 8963-8965 VBZ denotes is
T21912 8966-8970 VBN denotes lost
T21913 8971-8975 IN denotes upon
T21914 8976-8987 NN denotes development
T21915 8988-8990 IN denotes of
T21916 8991-8999 NN denotes lymphoma
T21917 8999-9000 . denotes .
T21918 9001-9006 NNP denotes Scale
T21919 9007-9010 NN denotes bar
T21920 9010-9011 , denotes ,
T21921 9012-9014 CD denotes 20
T21922 9015-9017 NN denotes μm
T21923 9017-9018 . denotes .
T253 0-3 NNP denotes EBV
T254 4-10 NNP denotes Latent
T5215 12836-12840 RB denotes also
T5216 12841-12847 RB denotes doubly
T5217 12848-12856 JJ denotes positive
T5218 12857-12860 IN denotes for
T5219 12861-12862 NN denotes κ
T5220 12863-12866 CC denotes and
T5221 12867-12868 NN denotes λ
T5222 12869-12874 NN denotes light
T5223 12875-12881 NNS denotes chains
T5224 12882-12883 NNP denotes [
T5225 12883-12885 CD denotes 31
T5226 12885-12886 NNP denotes ]
T5227 12886-12887 . denotes .
T5228 12888-12893 DT denotes These
T5229 12894-12902 NNS denotes findings
T5230 12903-12911 VBP denotes indicate
T5231 12912-12916 IN denotes that
T5232 12917-12927 NN denotes expression
T5233 12928-12930 IN denotes of
T5234 12931-12935 CD denotes LMP1
T5235 12936-12938 IN denotes in
T5236 12939-12943 JJ denotes B-1a
T5237 12944-12949 NNS denotes cells
T5238 12950-12958 VBZ denotes promotes
T5239 12959-12962 DT denotes the
T5240 12963-12974 NN denotes development
T5241 12975-12977 IN denotes of
T5242 12978-12988 NN denotes malignancy
T5243 12989-12992 CC denotes and
T5244 12993-12996 MD denotes can
T25453 31400-31407 NN denotes control
T25454 31407-31408 . denotes .
T25521 16904-16911 NN denotes Summary
T25522 16912-16914 IN denotes of
T25523 16915-16923 NNP denotes Analysis
T25524 16924-16933 NNP denotes Performed
T25525 16934-16936 IN denotes on
T25526 16937-16946 NNP denotes Wild-Type
T25527 16947-16950 CC denotes and
T25528 16951-16955 NNP denotes LMP1
T25529 16956-16966 NNP denotes Transgenic
T25530 16967-16976 NNP denotes Lymphomas
R9671 T12763 T12778 nummod LMP1,Pathways
R9672 T12764 T12778 compound Promotes,Pathways
R9673 T12765 T12778 compound Tumor,Pathways
R9674 T12766 T12769 preconj Growth,through
R9675 T12767 T12766 cc and,Growth
R9676 T12768 T12766 conj Survival,Growth
R9677 T12769 T12778 prep through,Pathways
R9678 T12770 T12769 pobj Activation,through
R9679 T12771 T12770 prep of,Activation
R9680 T12772 T12771 pobj Akt,of
R9681 T12773 T12772 punct ",",Akt
R9682 T12774 T12772 conj NFκB,Akt
R9683 T12775 T12774 punct ",",NFκB
R9684 T12776 T12774 cc and,NFκB
R9685 T12777 T12774 conj Stat3,NFκB
R9686 T12778 T12780 nsubj Pathways,explore
R9687 T12779 T12780 aux To,explore
R9688 T12780 T12780 ROOT explore,explore
R9689 T12781 T12782 det which,pathways
R9690 T12782 T12784 nsubjpass pathways,required
R9691 T12783 T12784 auxpass were,required
R9692 T12784 T12780 ccomp required,explore
R9693 T12785 T12784 prep for,required
R9694 T12786 T12788 det the,growth
R9695 T12787 T12788 amod enhanced,growth
R9696 T12788 T12785 pobj growth,for
R9697 T12789 T12788 cc and,growth
R9698 T12790 T12788 conj survival,growth
R9699 T12791 T12790 prep of,survival
R9700 T12792 T12793 amod LMP1-induced,lymphomas
R9701 T12793 T12791 pobj lymphomas,of
R9702 T12794 T12780 punct ",",explore
R9703 T12795 T12803 nsubjpass splenocytes,cultured
R9704 T12796 T12795 prep from,splenocytes
R9705 T12797 T12801 amod wild-type,mice
R9706 T12798 T12797 cc and,wild-type
R9707 T12799 T12797 conj LMP1,wild-type
R9708 T12800 T12801 amod transgenic,mice
R9709 T12801 T12796 pobj mice,from
R9710 T12802 T12803 auxpass were,cultured
R9711 T12803 T12780 conj cultured,explore
R9712 T12804 T12803 prep in,cultured
R9713 T12805 T12806 det the,presence
R9714 T12806 T12804 pobj presence,in
R9715 T12807 T12806 prep of,presence
R9716 T12808 T12807 pobj inhibitors,of
R9717 T12809 T12808 prep for,inhibitors
R9718 T12810 T12809 pobj Akt,for
R9719 T12811 T12810 punct ",",Akt
R9720 T12812 T12810 conj NFκB,Akt
R9721 T12813 T12812 punct ",",NFκB
R9722 T12814 T12812 conj Stat3,NFκB
R9723 T12815 T12814 punct ",",Stat3
R9724 T12816 T12814 conj mTOR,Stat3
R9725 T12817 T12816 punct ",",mTOR
R9726 T12818 T12816 cc or,mTOR
R9727 T12819 T12816 conj MAPK,mTOR
R9728 T12820 T12803 cc and,cultured
R9729 T12821 T12803 conj assayed,cultured
R9730 T12822 T12821 prep for,assayed
R9731 T12823 T12822 pobj growth,for
R9732 T12824 T12823 cc and,growth
R9733 T12825 T12823 conj survival,growth
R9734 T12826 T12821 agent by,assayed
R9735 T12827 T12829 det the,assay
R9736 T12828 T12829 compound MTS,assay
R9737 T12829 T12826 pobj assay,by
R9738 T12830 T12780 punct .,explore
R9739 T12831 T12833 mark As,shown
R9740 T12832 T12833 advmod previously,shown
R9741 T12833 T12837 advcl shown,were
R9742 T12834 T12837 punct ",",were
R9743 T12835 T12836 amod wild-type,lymphocytes
R9744 T12836 T12837 nsubj lymphocytes,were
R9745 T12837 T12837 ROOT were,were
R9746 T12838 T12837 neg not,were
R9747 T12839 T12837 acomp viable,were
R9748 T12840 T12839 prep in,viable
R9749 T12841 T12840 pobj culture,in
R9750 T12842 T12837 cc and,were
R9751 T12843 T12846 aux could,tested
R9752 T12844 T12846 neg not,tested
R9753 T12845 T12846 auxpass be,tested
R9754 T12846 T12837 conj tested,were
R9755 T12847 T12846 prep with,tested
R9756 T12848 T12849 det the,inhibitors
R9757 T12849 T12847 pobj inhibitors,with
R9758 T12850 T12837 punct .,were
R9759 T12851 T12862 advmod However,blocked
R9760 T12852 T12862 punct ",",blocked
R9761 T12853 T12855 det the,viability
R9762 T12854 T12855 amod enhanced,viability
R9763 T12855 T12862 nsubjpass viability,blocked
R9764 T12856 T12855 prep of,viability
R9765 T12857 T12859 nummod LMP1,lymphocytes
R9766 T12858 T12859 amod transgenic,lymphocytes
R9767 T12859 T12856 pobj lymphocytes,of
R9768 T12860 T12862 auxpass was,blocked
R9769 T12861 T12862 advmod effectively,blocked
R9770 T12862 T12862 ROOT blocked,blocked
R9771 T12863 T12862 agent by,blocked
R9772 T12864 T12863 pobj treatment,by
R9773 T12865 T12862 prep with,blocked
R9774 T12866 T12865 pobj triciribine,with
R9775 T12867 T12866 punct ",",triciribine
R9776 T12868 T12866 appos BAY11,triciribine
R9777 T12869 T12866 appos 7085,triciribine
R9778 T12870 T12866 punct ",",triciribine
R9779 T12871 T12866 conj cucurbitacin,triciribine
R9780 T12872 T12871 conj I,cucurbitacin
R9781 T12873 T12872 punct ",",I
R9782 T12874 T12872 cc and,I
R9783 T12875 T12876 advmod slightly,with
R9784 T12876 T12862 prep with,blocked
R9785 T12877 T12876 pobj SB203580,with
R9786 T12878 T12862 punct ",",blocked
R9787 T12879 T12862 cc but,blocked
R9788 T12880 T12881 neg not,by
R9789 T12881 T12862 conj by,blocked
R9790 T12882 T12881 pobj treatment,by
R9791 T12883 T12881 conj with,by
R9792 T12884 T12883 pobj rapamycin,with
R9793 T12885 T12884 punct ",",rapamycin
R9794 T12886 T12884 conj U0126,rapamycin
R9795 T12887 T12886 punct ",",U0126
R9796 T12888 T12886 cc or,U0126
R9797 T12889 T12886 conj AG490,U0126
R9798 T12890 T12891 punct (,Figure
R9799 T12891 T12889 appos Figure,AG490
R9800 T12892 T12891 nummod 7,Figure
R9801 T12893 T12889 punct ),AG490
R9802 T12894 T12862 punct .,blocked
R9803 T12895 T12896 nsubj Triciribine,inhibits
R9804 T12896 T12896 ROOT inhibits,inhibits
R9805 T12897 T12898 det the,activation
R9806 T12898 T12896 dobj activation,inhibits
R9807 T12899 T12898 prep of,activation
R9808 T12900 T12899 pobj Akt,of
R9809 T12901 T12896 cc and,inhibits
R9810 T12902 T12907 prep at,shown
R9811 T12903 T12904 nummod 20,μM
R9812 T12904 T12902 pobj μM,at
R9813 T12905 T12907 aux has,shown
R9814 T12906 T12907 auxpass been,shown
R9815 T12907 T12896 conj shown,inhibits
R9816 T12908 T12909 aux to,induce
R9817 T12909 T12907 xcomp induce,shown
R9818 T12910 T12911 compound growth,arrest
R9819 T12911 T12909 dobj arrest,induce
R9820 T12912 T12909 prep in,induce
R9821 T12913 T12914 compound cancer,cells
R9822 T12914 T12912 pobj cells,in
R9823 T12915 T12909 prep with,induce
R9824 T12916 T12918 amod aberrant,activity
R9825 T12917 T12918 compound Akt,activity
R9826 T12918 T12921 compound activity,]
R9827 T12919 T12921 nmod [,]
R9828 T12920 T12921 nummod 46,]
R9829 T12921 T12915 pobj ],with
R9830 T12922 T12896 punct .,inhibits
R9831 T12923 T12924 det The,effects
R9832 T12924 T12936 nsubj effects,were
R9833 T12925 T12924 prep of,effects
R9834 T12926 T12925 pobj triciribine,of
R9835 T12927 T12924 prep on,effects
R9836 T12928 T12929 compound cell,growth
R9837 T12929 T12927 pobj growth,on
R9838 T12930 T12929 prep of,growth
R9839 T12931 T12933 det the,lymphocytes
R9840 T12932 T12933 amod transgenic,lymphocytes
R9841 T12933 T12930 pobj lymphocytes,of
R9842 T12934 T12933 cc and,lymphocytes
R9843 T12935 T12933 conj lymphomas,lymphocytes
R9844 T12936 T12936 ROOT were,were
R9845 T12937 T12936 acomp apparent,were
R9846 T12938 T12939 advmod as,low
R9847 T12939 T12937 amod low,apparent
R9848 T12940 T12939 prep as,low
R9849 T12941 T12942 nummod 1,μM
R9850 T12942 T12940 pobj μM,as
R9851 T12943 T12936 punct ",",were
R9852 T12944 T12936 advcl suggesting,were
R9853 T12945 T12950 mark that,required
R9854 T12946 T12950 nsubjpass activation,required
R9855 T12947 T12946 prep of,activation
R9856 T12948 T12947 pobj Akt,of
R9857 T12949 T12950 auxpass is,required
R9858 T12950 T12944 ccomp required,suggesting
R9859 T12951 T12950 prep for,required
R9860 T12952 T12953 det the,survival
R9861 T12953 T12951 pobj survival,for
R9862 T12954 T12953 cc and,survival
R9863 T12955 T12953 conj growth,survival
R9864 T12956 T12953 prep of,survival
R9865 T12957 T12959 nummod LMP1,lymphocytes
R9866 T12958 T12959 amod transgenic,lymphocytes
R9867 T12959 T12956 pobj lymphocytes,of
R9868 T12960 T12959 cc and,lymphocytes
R9869 T12961 T12962 compound lymphoma,cells
R9870 T12962 T12959 conj cells,lymphocytes
R9871 T12963 T12964 punct (,Figure
R9872 T12964 T12959 appos Figure,lymphocytes
R9873 T12965 T12964 nummod 7,Figure
R9874 T12966 T12964 punct ),Figure
R9875 T12967 T12936 punct .,were
R9876 T12968 T12969 det The,effects
R9877 T12969 T12974 nsubjpass effects,assessed
R9878 T12970 T12969 prep of,effects
R9879 T12971 T12972 det the,inhibitors
R9880 T12972 T12970 pobj inhibitors,of
R9881 T12973 T12974 auxpass were,assessed
R9882 T12974 T12974 ROOT assessed,assessed
R9883 T12975 T12974 prep by,assessed
R9884 T12976 T12975 pcomp identifying,by
R9885 T12977 T12978 compound phosphorylated,Akt
R9886 T12978 T12976 dobj Akt,identifying
R9887 T12979 T12978 punct ",",Akt
R9888 T12980 T12978 conj Stat3,Akt
R9889 T12981 T12980 punct ",",Stat3
R9890 T12982 T12980 cc and,Stat3
R9891 T12983 T12984 amod total,levels
R9892 T12984 T12978 appos levels,Akt
R9893 T12985 T12984 prep of,levels
R9894 T12986 T12985 pobj IκBα,of
R9895 T12987 T12988 punct (,Figure
R9896 T12988 T12986 appos Figure,IκBα
R9897 T12989 T12988 nummod 8,Figure
R9898 T12990 T12986 punct ),IκBα
R9899 T12991 T12974 punct .,assessed
R9900 T12992 T13004 nsubj Treatment,was
R9901 T12993 T12992 prep with,Treatment
R9902 T12994 T12997 amod triciribine,phosphorylation
R9903 T12995 T12996 advmod effectively,blocked
R9904 T12996 T12997 amod blocked,phosphorylation
R9905 T12997 T12993 pobj phosphorylation,with
R9906 T12998 T12997 prep of,phosphorylation
R9907 T12999 T12998 pobj Akt,of
R9908 T13000 T12992 punct ",",Treatment
R9909 T13001 T12992 cc and,Treatment
R9910 T13002 T13003 compound phosphorylated,Akt
R9911 T13003 T12992 conj Akt,Treatment
R9912 T13004 T13007 auxpass was,detected
R9913 T13005 T13006 neg no,longer
R9914 T13006 T13007 advmod longer,detected
R9915 T13007 T13007 ROOT detected,detected
R9916 T13008 T13010 amod past,μM
R9917 T13009 T13010 nummod 5,μM
R9918 T13010 T13007 dobj μM,detected
R9919 T13011 T13007 punct .,detected
R9920 T13012 T13013 compound Phosphorylated,Stat3
R9921 T13013 T13016 nsubj Stat3,were
R9922 T13014 T13013 cc and,Stat3
R9923 T13015 T13013 conj IκBα,Stat3
R9924 T13016 T13016 ROOT were,were
R9925 T13017 T13016 advmod still,were
R9926 T13018 T13016 acomp present,were
R9927 T13019 T13018 prep at,present
R9928 T13020 T13021 nummod 25,μM
R9929 T13021 T13019 pobj μM,at
R9930 T13022 T13016 punct .,were
R9931 T13023 T13024 det These,findings
R9932 T13024 T13025 nsubj findings,suggest
R9933 T13025 T13025 ROOT suggest,suggest
R9934 T13026 T13029 mark that,targets
R9935 T13027 T13029 nsubj triciribine,targets
R9936 T13028 T13029 advmod specifically,targets
R9937 T13029 T13025 ccomp targets,suggest
R9938 T13030 T13029 dobj Akt,targets
R9939 T13031 T13029 cc and,targets
R9940 T13032 T13036 mark that,required
R9941 T13033 T13034 compound Akt,activation
R9942 T13034 T13036 nsubjpass activation,required
R9943 T13035 T13036 auxpass is,required
R9944 T13036 T13029 conj required,targets
R9945 T13037 T13036 prep for,required
R9946 T13038 T13040 det the,viability
R9947 T13039 T13040 amod enhanced,viability
R9948 T13040 T13037 pobj viability,for
R9949 T13041 T13040 prep of,viability
R9950 T13042 T13044 det the,lymphocytes
R9951 T13043 T13044 amod transgenic,lymphocytes
R9952 T13044 T13041 pobj lymphocytes,of
R9953 T13045 T13044 cc and,lymphocytes
R9954 T13046 T13047 compound lymphoma,cells
R9955 T13047 T13044 conj cells,lymphocytes
R9956 T13048 T13025 punct .,suggest
R9957 T13049 T13054 nsubj Inhibition,induces
R9958 T13050 T13049 prep of,Inhibition
R9959 T13051 T13050 pobj NFκB,of
R9960 T13052 T13054 nsubj signaling,induces
R9961 T13053 T13054 advmod rapidly,induces
R9962 T13054 T13054 ROOT induces,induces
R9963 T13055 T13056 compound cell,death
R9964 T13056 T13054 dobj death,induces
R9965 T13057 T13056 prep of,death
R9966 T13058 T13059 amod EBV-transformed,lymphocytes
R9967 T13059 T13057 pobj lymphocytes,of
R9968 T13060 T13062 compound [,]
R9969 T13061 T13062 compound "17,18",]
R9970 T13062 T13054 dobj ],induces
R9971 T13063 T13054 punct .,induces
R9972 T13064 T13075 nsubj BAY11,decreased
R9973 T13065 T13064 appos 7085,BAY11
R9974 T13066 T13064 punct ",",BAY11
R9975 T13067 T13068 det an,inhibitor
R9976 T13068 T13064 appos inhibitor,BAY11
R9977 T13069 T13068 prep of,inhibitor
R9978 T13070 T13069 pobj NFκB,of
R9979 T13071 T13068 acl signaling,inhibitor
R9980 T13072 T13071 punct ",",signaling
R9981 T13073 T13075 advmod also,decreased
R9982 T13074 T13075 advmod greatly,decreased
R9983 T13075 T13075 ROOT decreased,decreased
R9984 T13076 T13077 det the,viability
R9985 T13077 T13075 dobj viability,decreased
R9986 T13078 T13077 prep of,viability
R9987 T13079 T13082 det the,lymphocytes
R9988 T13080 T13082 compound LMP1,lymphocytes
R9989 T13081 T13082 compound transgenic,lymphocytes
R9990 T13082 T13078 pobj lymphocytes,of
R9991 T13083 T13082 cc and,lymphocytes
R9992 T13084 T13085 compound lymphoma,cells
R9993 T13085 T13082 conj cells,lymphocytes
R9994 T13086 T13075 prep at,decreased
R9995 T13087 T13086 pobj doses,at
R9996 T13088 T13089 advmod as,low
R9997 T13089 T13087 amod low,doses
R9998 T13090 T13089 prep as,low
R9999 T13091 T13092 nummod 1,μM
R10000 T13092 T13090 pobj μM,as
R10001 T13093 T13092 punct ",",μM
R10002 T13094 T13086 cc and,at
R10003 T13095 T13086 conj at,at
R10004 T13096 T13097 nummod 5,μM
R10005 T13097 T13095 pobj μM,at
R10006 T13098 T13099 det the,cells
R10007 T13099 T13100 nsubj cells,were
R10008 T13100 T13075 conj were,decreased
R10009 T13101 T13102 advmod completely,nonviable
R10010 T13102 T13100 acomp nonviable,were
R10011 T13103 T13104 punct (,Figure
R10012 T13104 T13102 parataxis Figure,nonviable
R10013 T13105 T13104 nummod 7,Figure
R10014 T13106 T13104 punct ),Figure
R10015 T13107 T13100 punct .,were
R10039 T13131 T13129 prep to,present
R10040 T13132 T13131 pobj treatment,to
R10041 T13133 T13129 prep with,present
R10042 T13134 T13135 nummod 15,μM
R10043 T13135 T13133 pobj μM,with
R10044 T13136 T13127 cc and,were
R10045 T13137 T13141 advmod then,detected
R10046 T13138 T13141 auxpass were,detected
R10047 T13139 T13140 neg no,longer
R10048 T13140 T13141 advmod longer,detected
R10049 T13141 T13127 conj detected,were
R10050 T13142 T13143 punct (,Figure
R10051 T13143 T13141 oprd Figure,detected
R10052 T13144 T13143 nummod 8,Figure
R10053 T13145 T13143 punct ),Figure
R10054 T13146 T13127 punct .,were
R10055 T13147 T13148 det This,finding
R10056 T13148 T13149 nsubj finding,suggests
R10057 T13149 T13149 ROOT suggests,suggests
R10058 T13150 T13155 mark that,induce
R10059 T13151 T13155 nsubj inhibition,induce
R10060 T13152 T13151 prep of,inhibition
R10061 T13153 T13152 pobj NFκB,of
R10062 T13154 T13155 aux can,induce
R10063 T13155 T13149 ccomp induce,suggests
R10064 T13156 T13157 compound cell,death
R10065 T13157 T13155 dobj death,induce
R10066 T13158 T13155 prep in,induce
R10067 T13159 T13161 nummod LMP1,lymphocytes
R10068 T13160 T13161 amod transgenic,lymphocytes
R10069 T13161 T13158 pobj lymphocytes,in
R10070 T13162 T13161 cc and,lymphocytes
R10071 T13163 T13164 compound lymphoma,cells
R10072 T13164 T13161 conj cells,lymphocytes
R10073 T13165 T13155 prep without,induce
R10074 T13166 T13167 amod significant,effects
R10075 T13167 T13165 pobj effects,without
R10076 T13168 T13167 prep on,effects
R10077 T13169 T13168 pobj activation,on
R10078 T13170 T13169 prep of,activation
R10079 T13171 T13170 pobj Akt,of
R10080 T13172 T13171 cc or,Akt
R10081 T13173 T13171 conj Stat3,Akt
R10082 T13174 T13149 punct .,suggests
R10083 T13175 T13177 intj Cucurbitacin,inhibits
R10084 T13176 T13177 nsubj I,inhibits
R10085 T13177 T13177 ROOT inhibits,inhibits
R10086 T13178 T13177 dobj activation,inhibits
R10087 T13179 T13178 prep of,activation
R10088 T13180 T13179 pobj Stat3,of
R10089 T13181 T13177 prep by,inhibits
R10090 T13182 T13181 pcomp suppressing,by
R10091 T13183 T13184 det the,activation
R10092 T13184 T13182 dobj activation,suppressing
R10093 T13185 T13184 prep of,activation
R10094 T13186 T13188 poss its,JAK2
R10095 T13187 T13188 compound kinase,JAK2
R10096 T13188 T13185 pobj JAK2,of
R10097 T13189 T13177 punct .,inhibits
R10098 T13190 T13193 nsubjpass It,shown
R10099 T13191 T13193 aux has,shown
R10100 T13192 T13193 auxpass been,shown
R10101 T13193 T13193 ROOT shown,shown
R10102 T13194 T13196 aux to,inhibit
R10103 T13195 T13196 advmod selectively,inhibit
R10104 T13196 T13193 xcomp inhibit,shown
R10105 T13197 T13198 det the,growth
R10106 T13198 T13196 dobj growth,inhibit
R10107 T13199 T13198 prep of,growth
R10108 T13200 T13199 pobj tumors,of
R10109 T13201 T13198 prep with,growth
R10110 T13202 T13203 nsubj constitutively,activated
R10111 T13203 T13205 amod activated,[
R10112 T13204 T13205 compound Stat3,[
R10113 T13205 T13201 pobj [,with
R10114 T13206 T13207 nummod 47,]
R10115 T13207 T13205 appos ],[
R10116 T13208 T13193 punct .,shown
R10117 T13209 T13217 advmod Similarly,were
R10118 T13210 T13217 punct ",",were
R10119 T13211 T13213 nmod LMP1,lymphocytes
R10120 T13212 T13213 amod transgenic,lymphocytes
R10121 T13213 T13217 nsubj lymphocytes,were
R10122 T13214 T13213 cc and,lymphocytes
R10123 T13215 T13216 compound lymphoma,cells
R10124 T13216 T13213 conj cells,lymphocytes
R10125 T13217 T13217 ROOT were,were
R10126 T13218 T13217 acomp susceptible,were
R10127 T13219 T13220 aux to,cucurbitacin
R10128 T13220 T13218 xcomp cucurbitacin,susceptible
R10129 T13221 T13222 compound I,treatment
R10130 T13222 T13220 dobj treatment,cucurbitacin
R10131 T13223 T13220 advcl starting,cucurbitacin
R10132 T13224 T13223 prep at,starting
R10133 T13225 T13226 nummod 0.1,μM
R10134 T13226 T13224 pobj μM,at
R10135 T13227 T13226 punct ",",μM
R10136 T13228 T13229 det a,dose
R10137 T13229 T13226 appos dose,μM
R10138 T13230 T13231 nsubj that,corresponds
R10139 T13231 T13229 relcl corresponds,dose
R10140 T13232 T13231 advmod closely,corresponds
R10141 T13233 T13231 prep to,corresponds
R10142 T13234 T13236 det the,IC50
R10143 T13235 T13236 amod reported,IC50
R10144 T13236 T13233 pobj IC50,to
R10145 T13237 T13236 prep of,IC50
R10146 T13238 T13239 nummod 500,nM
R10147 T13239 T13237 pobj nM,of
R10148 T13240 T13241 punct (,Figure
R10149 T13241 T13239 appos Figure,nM
R10150 T13242 T13241 nummod 7,Figure
R10151 T13243 T13239 punct ),nM
R10152 T13244 T13246 nmod [,]
R10153 T13245 T13246 nummod 47,]
R10154 T13246 T13236 appos ],IC50
R10155 T13247 T13217 punct .,were
R10156 T13248 T13249 compound Phosphorylated,Akt
R10157 T13249 T13256 nsubj Akt,were
R10158 T13250 T13249 punct ",",Akt
R10159 T13251 T13249 conj Stat3,Akt
R10160 T13252 T13251 punct ",",Stat3
R10161 T13253 T13251 cc and,Stat3
R10162 T13254 T13255 amod total,IκBα
R10163 T13255 T13251 conj IκBα,Stat3
R10164 T13256 T13256 ROOT were,were
R10165 T13257 T13256 neg not,were
R10166 T13258 T13256 acomp detectable,were
R10167 T13259 T13258 prep past,detectable
R10168 T13260 T13261 nummod 1,μM
R10169 T13261 T13259 pobj μM,past
R10170 T13262 T13256 cc and,were
R10171 T13263 T13271 prep at,decreased
R10194 T13286 T13287 nsubj second,reported
R10195 T13287 T13287 ROOT reported,reported
R10196 T13288 T13287 dobj inhibitor,reported
R10197 T13289 T13288 prep of,inhibitor
R10198 T13290 T13289 pobj Stat3,of
R10199 T13291 T13290 punct ",",Stat3
R10200 T13292 T13290 appos AG490,Stat3
R10201 T13293 T13294 punct ",",had
R10202 T13294 T13287 advcl had,reported
R10203 T13295 T13296 det no,effect
R10204 T13296 T13294 dobj effect,had
R10205 T13297 T13296 prep on,effect
R10206 T13298 T13297 pobj growth,on
R10207 T13299 T13300 punct (,Figure
R10208 T13300 T13298 appos Figure,growth
R10209 T13301 T13300 nummod 7,Figure
R10210 T13302 T13300 punct ),Figure
R10211 T13303 T13294 punct ",",had
R10212 T13304 T13287 cc but,reported
R10213 T13305 T13315 nsubj activation,were
R10214 T13306 T13305 prep of,activation
R10215 T13307 T13306 pobj Akt,of
R10216 T13308 T13307 punct ",",Akt
R10217 T13309 T13307 conj Stat3,Akt
R10218 T13310 T13309 punct ",",Stat3
R10219 T13311 T13309 cc or,Stat3
R10220 T13312 T13305 conj levels,activation
R10221 T13313 T13312 prep of,levels
R10222 T13314 T13313 pobj IκBα,of
R10223 T13315 T13287 conj were,reported
R10224 T13316 T13315 advmod also,were
R10225 T13317 T13318 neg not,affected
R10226 T13318 T13315 prep affected,were
R10227 T13319 T13320 punct (,Figure
R10249 T13341 T13338 conj cells,lymphocytes
R10273 T13365 T13364 cc and,JNK
R10274 T13366 T13368 nummod p38,pathways
R10275 T13367 T13368 compound MAPK,pathways
R10276 T13368 T13377 nsubj pathways,were
R10277 T13369 T13371 compound [,]
R10278 T13370 T13371 compound "13,48",]
R10279 T13371 T13368 appos ],pathways
R10280 T13372 T13371 punct ",",]
R10281 T13373 T13371 cc and,]
R10282 T13374 T13371 conj LMP1,]
R10283 T13375 T13376 amod transgenic,lymphocytes
R10284 T13376 T13368 conj lymphocytes,pathways
R10285 T13377 T13361 conj were,shown
R10286 T13378 T13379 advmod mildly,susceptible
R10287 T13379 T13377 acomp susceptible,were
R10288 T13380 T13379 prep to,susceptible
R10289 T13381 T13382 compound growth,inhibition
R10290 T13382 T13380 pobj inhibition,to
R10291 T13383 T13382 prep by,inhibition
R10292 T13384 T13383 pobj SB202190,by
R10293 T13385 T13384 punct ",",SB202190
R10294 T13386 T13387 det an,inhibitor
R10295 T13387 T13384 appos inhibitor,SB202190
R10296 T13388 T13387 prep of,inhibitor
R10297 T13389 T13390 nummod p38,MAPK
R10298 T13390 T13388 pobj MAPK,of
R10299 T13391 T13377 punct ",",were
R10300 T13392 T13377 cc but,were
R10301 T13393 T13394 neg not,U0126
R10302 T13394 T13394 ROOT U0126,U0126
R10303 T13395 T13394 punct ",",U0126
R10304 T13396 T13397 det an,inhibitor
R10305 T13397 T13394 appos inhibitor,U0126
R10328 T13420 T13407 acomp higher,were
R10329 T13421 T13420 prep than,higher
R10330 T13422 T13424 det the,IC50
R10331 T13423 T13424 amod reported,IC50
R10332 T13424 T13421 pobj IC50,than
R10333 T13425 T13424 prep of,IC50
R10334 T13426 T13427 nummod 0.35,μM
R10335 T13427 T13425 pobj μM,of
R10336 T13428 T13407 punct ",",were
R10337 T13429 T13407 advcl suggesting,were
R10338 T13430 T13436 mark that,contribute
R10339 T13431 T13432 compound p38,MAPK
R10340 T13432 T13436 nsubj MAPK,contribute
R10341 T13433 T13436 aux does,contribute
R10342 T13434 T13436 neg not,contribute
R10343 T13435 T13436 advmod significantly,contribute
R10344 T13436 T13429 ccomp contribute,suggesting
R10345 T13437 T13436 prep to,contribute
R10346 T13438 T13440 det the,viability
R10347 T13439 T13440 amod enhanced,viability
R10348 T13440 T13437 pobj viability,to
R10349 T13441 T13440 prep in,viability
R10350 T13442 T13444 nummod LMP1,lymphocytes
R10351 T13443 T13444 amod transgenic,lymphocytes
R10352 T13444 T13441 pobj lymphocytes,in
R10353 T13445 T13444 cc or,lymphocytes
R10354 T13446 T13447 compound lymphoma,cells
R10355 T13447 T13444 conj cells,lymphocytes
R10356 T13448 T13449 punct (,Figure
R10357 T13449 T13447 appos Figure,cells
R10358 T13450 T13449 nummod 7,Figure
R10359 T13451 T13449 punct ),Figure
R10360 T13452 T13407 punct .,were
R10361 T13453 T13461 advmod Interestingly,were
R10362 T13454 T13461 punct ",",were
R10363 T13455 T13456 preconj both,wild-type
R10364 T13456 T13460 amod wild-type,lymphomas
R10365 T13457 T13456 cc and,wild-type
R10366 T13458 T13456 conj LMP1,wild-type
R10367 T13459 T13460 amod transgenic,lymphomas
R10368 T13460 T13461 nsubj lymphomas,were
R10369 T13461 T13461 ROOT were,were
R10370 T13462 T13463 advmod similarly,susceptible
R10371 T13463 T13461 acomp susceptible,were
R10372 T13464 T13463 prep to,susceptible
R10373 T13465 T13464 pobj triciribine,to
R10374 T13466 T13461 punct ",",were
R10375 T13467 T13473 nmod BAY11,treatments
R10376 T13468 T13467 appos 7085,BAY11
R10377 T13469 T13467 punct ",",BAY11
R10378 T13470 T13467 cc and,BAY11
R10379 T13471 T13467 conj cucurbitacin,BAY11
R10380 T13472 T13473 nsubj I,treatments
R10381 T13473 T13461 advcl treatments,were
R10382 T13474 T13473 punct ",",treatments
R10383 T13475 T13473 cc but,treatments
R10384 T13476 T13477 neg not,SB202190
R10385 T13477 T13473 conj SB202190,treatments
R10386 T13478 T13477 punct ",",SB202190
R10387 T13479 T13477 conj AG490,SB202190
R10388 T13480 T13479 punct ",",AG490
R10389 T13481 T13479 cc or,AG490
R10390 T13482 T13479 conj U0126,AG490
R10391 T13483 T13473 conj treatment,treatments
R10392 T13484 T13461 punct ",",were
R10393 T13485 T13461 advcl suggesting,were
R10394 T13486 T13499 mark that,are
R10395 T13487 T13499 nsubj activation,are
R10396 T13488 T13487 prep of,activation
R10397 T13489 T13488 pobj Akt,of
R10398 T13490 T13489 punct ",",Akt
R10399 T13491 T13489 conj NFκB,Akt
R10400 T13492 T13491 punct ",",NFκB
R10401 T13493 T13491 cc and,NFκB
R10402 T13494 T13491 conj Stat3,NFκB
R10403 T13495 T13494 cc but,Stat3
R10404 T13496 T13497 neg not,MAPK
R10405 T13497 T13494 conj MAPK,Stat3
R10406 T13498 T13487 conj pathways,activation
R10432 T13524 T13525 amod transgenic,lymphocytes
R10433 T13525 T13522 pobj lymphocytes,of
R10434 T13526 T13525 cc or,lymphocytes
R10435 T13527 T13528 compound lymphoma,cells
R10436 T13528 T13525 conj cells,lymphocytes
R10437 T13529 T13519 punct ",",affect
R10438 T13530 T13519 advcl confirming,affect
R10439 T13531 T13535 mark that,targeted
R10440 T13532 T13535 nsubjpass mTOR,targeted
R10441 T13533 T13535 auxpass is,targeted
R10442 T13534 T13535 neg not,targeted
R10443 T13535 T13530 ccomp targeted,confirming
R10444 T13536 T13535 agent by,targeted
R10445 T13537 T13538 compound Akt,activation
R10446 T13538 T13536 pobj activation,by
R10447 T13539 T13535 prep in,targeted
R10448 T13540 T13542 nummod LMP1,lymphocytes
R10449 T13541 T13542 amod transgenic,lymphocytes
R10450 T13542 T13539 pobj lymphocytes,in
R10451 T13543 T13542 cc or,lymphocytes
R10452 T13544 T13546 amod malignant,cells
R10453 T13545 T13546 compound lymphoma,cells
R10454 T13546 T13542 conj cells,lymphocytes
R10455 T13547 T13548 punct (,Figure
R10456 T13548 T13542 appos Figure,lymphocytes
R10457 T13549 T13548 nummod 7,Figure
R10458 T13550 T13548 punct ),Figure
R10459 T13551 T13519 punct .,affect
R187 T275 T271 punct ),protein
R188 T276 T276 ROOT is,is
R189 T277 T279 det the,oncoprotein
R190 T278 T279 amod major,oncoprotein
R191 T279 T276 attr oncoprotein,is
R192 T280 T279 prep of,oncoprotein
R193 T281 T282 compound Epstein-Barr,virus
R194 T282 T280 pobj virus,of
R195 T283 T284 punct (,EBV
R196 T284 T282 appos EBV,virus
R197 T285 T279 punct ),oncoprotein
R198 T286 T276 punct .,is
R199 T287 T292 prep In,promotes
R200 T288 T289 amod transgenic,mice
R201 T289 T287 pobj mice,In
R202 T290 T292 punct ",",promotes
R203 T291 T292 nsubj LMP1,promotes
R204 T292 T292 ROOT promotes,promotes
R205 T293 T295 amod increased,development
R206 T294 T295 compound lymphoma,development
R207 T295 T292 dobj development,promotes
R208 T296 T292 prep by,promotes
R209 T297 T298 nummod 12,mo
R210 T298 T296 pobj mo,by
R211 T299 T298 prep of,mo
R212 T300 T299 pobj age,of
R213 T301 T292 punct .,promotes
R214 T302 T303 det This,study
R215 T303 T304 nsubj study,reveals
R216 T304 T304 ROOT reveals,reveals
R217 T305 T307 mark that,develops
R218 T306 T307 nsubj lymphoma,develops
R219 T307 T304 ccomp develops,reveals
R220 T308 T307 prep in,develops
R221 T309 T310 compound B-1a,lymphocytes
R222 T310 T308 pobj lymphocytes,in
R223 T311 T307 punct ",",develops
R224 T312 T313 det a,population
R225 T313 T307 dobj population,develops
R226 T314 T316 nsubjpass that,associated
R227 T315 T316 auxpass is,associated
R228 T316 T313 relcl associated,population
R229 T317 T316 prep with,associated
R230 T318 T317 pobj transformation,with
R231 T319 T318 prep in,transformation
R232 T320 T321 amod older,mice
R233 T321 T319 pobj mice,in
R234 T322 T304 punct .,reveals
R235 T323 T325 det The,cells
R236 T324 T325 compound lymphoma,cells
R237 T325 T327 nsubj cells,deregulated
R238 T326 T327 aux have,deregulated
R239 T327 T327 ROOT deregulated,deregulated
R240 T328 T329 compound cell,cycle
R241 T329 T330 compound cycle,markers
R242 T330 T327 dobj markers,deregulated
R243 T331 T330 punct ",",markers
R244 T332 T330 cc and,markers
R245 T333 T330 conj inhibitors,markers
R246 T334 T330 prep of,markers
R247 T335 T334 pobj Akt,of
R248 T336 T335 punct ",",Akt
R249 T337 T335 conj NFκB,Akt
R250 T338 T337 punct ",",NFκB
R251 T339 T337 cc and,NFκB
R252 T340 T341 amod Stat3,block
R253 T341 T330 appos block,markers
R254 T342 T344 det the,viability
R255 T343 T344 amod enhanced,viability
R256 T344 T341 dobj viability,block
R257 T345 T344 prep of,viability
R258 T346 T348 nummod LMP1,lymphocytes
R259 T347 T348 amod transgenic,lymphocytes
R260 T348 T345 pobj lymphocytes,of
R261 T349 T348 cc and,lymphocytes
R262 T350 T351 compound lymphoma,cells
R263 T351 T348 conj cells,lymphocytes
R264 T352 T344 prep in,viability
R265 T353 T352 pobj vitro,in
R266 T354 T327 punct .,deregulated
R267 T355 T356 compound Lymphoma,cells
R268 T356 T357 nsubj cells,are
R269 T357 T357 ROOT are,are
R270 T358 T357 acomp independent,are
R271 T359 T358 prep of,independent
R272 T360 T359 pobj IL4/Stat6,of
R273 T361 T357 advcl signaling,are
R274 T362 T361 prep for,signaling
R275 T363 T362 pobj survival,for
R276 T364 T363 cc and,survival
R277 T365 T363 conj proliferation,survival
R278 T366 T357 punct ",",are
R279 T367 T357 cc but,are
R280 T368 T370 aux have,activated
R281 T369 T370 advmod constitutively,activated
R282 T370 T357 conj activated,are
R283 T371 T372 amod Stat3,signaling
R284 T372 T370 dobj signaling,activated
R285 T373 T357 punct .,are
R286 T374 T376 det These,targets
R287 T375 T376 amod same,targets
R288 T376 T379 nsubjpass targets,deregulated
R289 T377 T379 auxpass are,deregulated
R290 T378 T379 advmod also,deregulated
R291 T379 T379 ROOT deregulated,deregulated
R292 T380 T379 prep in,deregulated
R293 T381 T383 amod wild-type,lymphomas
R294 T382 T383 compound B-1a,lymphomas
R295 T383 T380 pobj lymphomas,in
R296 T384 T385 nsubj that,arise
R297 T385 T383 relcl arise,lymphomas
R298 T386 T385 advmod spontaneously,arise
R299 T387 T385 prep through,arise
R300 T388 T389 compound age,predisposition
R301 T389 T387 pobj predisposition,through
R302 T390 T379 punct .,deregulated
R303 T391 T392 det These,results
R304 T392 T393 nsubj results,suggest
R305 T393 T393 ROOT suggest,suggest
R306 T394 T403 mark that,serve
R307 T395 T403 nsubj Akt,serve
R308 T396 T395 punct ",",Akt
R309 T397 T395 conj NFκB,Akt
R310 T398 T397 punct ",",NFκB
R311 T399 T397 cc and,NFκB
R312 T400 T401 amod Stat3,pathways
R313 T401 T397 conj pathways,NFκB
R314 T402 T403 aux may,serve
R315 T403 T393 ccomp serve,suggest
R316 T404 T403 prep as,serve
R317 T405 T406 amod effective,targets
R318 T406 T404 pobj targets,as
R319 T407 T406 prep in,targets
R320 T408 T409 det the,treatment
R321 T409 T407 pobj treatment,in
R322 T410 T409 prep of,treatment
R323 T411 T414 amod EBV-associated,lymphomas
R324 T412 T413 compound B,cell
R325 T413 T414 compound cell,lymphomas
R326 T414 T410 pobj lymphomas,of
R327 T415 T393 punct .,suggest
R1343 T1774 T1775 compound Epstein-Barr,virus
R1345 T1775 T1779 nsubj virus,is
R1346 T1776 T1777 punct (,EBV
R1347 T1777 T1775 appos EBV,virus
R1348 T1778 T1775 punct ),virus
R1350 T1779 T1779 ROOT is,is
R1351 T1780 T1782 det a,γ-herpesvirus
R1353 T1781 T1782 amod ubiquitous,γ-herpesvirus
R1355 T1782 T1779 attr γ-herpesvirus,is
R1356 T1783 T1784 nsubj that,infects
R1358 T1784 T1782 relcl infects,γ-herpesvirus
R1360 T1785 T1784 dobj humans,infects
R1362 T1786 T1784 advmod predominantly,infects
R1364 T1787 T1784 prep at,infects
R1365 T1788 T1790 det an,age
R1366 T1789 T1790 amod early,age
R1367 T1790 T1787 pobj age,at
R1370 T1791 T1784 prep with,infects
R1372 T1792 T1794 amod greater,90
R1373 T1793 T1794 quantmod than,90
R1374 T1794 T1795 nummod 90,%
R1375 T1795 T1791 pobj %,with
R1376 T1796 T1795 prep of,%
R1377 T1797 T1799 det the,population
R1378 T1798 T1799 compound adult,population
R1379 T1799 T1796 pobj population,of
R1380 T1800 T1799 acl infected,population
R1382 T1801 T1800 prep with,infected
R1384 T1802 T1803 compound EBV,[
R1386 T1869 T1870 det this,ability
R1387 T1803 T1801 pobj [,with
R1388 T1870 T1877 nsubj ability,contributes
R1389 T1804 T1805 nummod 1,]
R1390 T1805 T1803 appos ],[
R1391 T1806 T1779 punct .,is
R1392 T1807 T1809 nsubjpass EBV,linked
R1393 T1808 T1809 auxpass is,linked
R1394 T1809 T1809 ROOT linked,linked
R1395 T1810 T1809 prep to,linked
R1396 T1871 T1872 aux to,affect
R1397 T1811 T1812 det the,development
R1398 T1812 T1810 pobj development,to
R1399 T1813 T1812 prep of,development
R1400 T1814 T1816 det both,lymphocyte
R1401 T1872 T1870 acl affect,ability
R1402 T1815 T1816 compound B,lymphocyte
R1403 T1816 T1813 pobj lymphocyte,of
R1404 T1817 T1816 cc and,lymphocyte
R1405 T1873 T1874 compound cell,growth
R1406 T1818 T1820 amod epithelial,malignancies
R1407 T1819 T1820 compound cell,malignancies
R1408 T1820 T1816 conj malignancies,lymphocyte
R1409 T1821 T1820 punct ",",malignancies
R1410 T1874 T1875 compound growth,regulation
R1411 T1822 T1820 prep including,malignancies
R1412 T1823 T1824 compound Burkitt,lymphoma
R1413 T1824 T1822 pobj lymphoma,including
R1414 T1825 T1824 punct ",",lymphoma
R1415 T1875 T1872 dobj regulation,affect
R1416 T1826 T1827 compound Hodgkin,disease
R1417 T1827 T1824 conj disease,lymphoma
R1418 T1828 T1829 punct (,HD
R1419 T1876 T1877 nsubj likely,contributes
R1420 T1829 T1827 appos HD,disease
R1421 T1830 T1827 punct ),disease
R1422 T1831 T1827 punct ",",disease
R1423 T1877 T1863 conj contributes,induces
R1424 T1832 T1827 cc and,disease
R1425 T1833 T1834 amod nasopharyngeal,carcinoma
R1426 T1834 T1827 conj carcinoma,disease
R1427 T1835 T1834 punct (,carcinoma
R1428 T1878 T1877 prep to,contributes
R1429 T1836 T1834 npadvmod NPC,carcinoma
R1430 T1837 T1834 punct ),carcinoma
R1431 T1838 T1834 punct ",",carcinoma
R1432 T1879 T1880 det the,development
R1433 T1880 T1878 pobj development,to
R1434 T1839 T1834 cc and,carcinoma
R1435 T1840 T1834 conj cancers,carcinoma
R1436 T1881 T1880 prep of,development
R1437 T1841 T1840 acl linked,cancers
R1438 T1842 T1841 prep to,linked
R1439 T1843 T1842 pobj immunosuppression,to
R1440 T1882 T1881 pobj cancer,of
R1441 T1844 T1843 punct ",",immunosuppression
R1442 T1845 T1843 prep including,immunosuppression
R1443 T1846 T1847 amod post-transplant,lymphoma
R1444 T1847 T1845 pobj lymphoma,including
R1445 T1848 T1847 cc and,lymphoma
R1446 T1849 T1850 amod AIDS-associated,lymphomas
R1447 T1883 T1877 punct .,contributes
R1448 T1850 T1847 conj lymphomas,lymphoma
R1449 T1851 T1853 compound [,]
R1450 T1852 T1853 compound "2,3",]
R1451 T1884 T1889 nsubj Many,expressed
R1452 T1853 T1847 conj ],lymphoma
R1453 T1854 T1809 punct .,linked
R1454 T1855 T1863 prep In,induces
R1455 T1856 T1857 amod vitro,infection
R1456 T1885 T1884 prep of,Many
R1457 T1857 T1855 pobj infection,In
R1458 T1858 T1857 prep of,infection
R1459 T1859 T1860 compound B,lymphocytes
R1460 T1886 T1888 det the,proteins
R1461 T1860 T1858 pobj lymphocytes,of
R1462 T1861 T1857 prep with,infection
R1463 T1862 T1861 pobj EBV,with
R1464 T1887 T1888 amod viral,proteins
R1465 T1863 T1863 ROOT induces,induces
R1466 T1864 T1866 amod permanent,transformation
R1467 T1865 T1866 compound growth,transformation
R1468 T1866 T1863 dobj transformation,induces
R1469 T1888 T1885 pobj proteins,of
R1470 T1867 T1863 punct ",",induces
R1471 T1889 T1904 nsubj expressed,have
R1472 T1890 T1889 prep in,expressed
R1473 T1868 T1863 cc and,induces
R1474 T1891 T1892 amod transformed,cells
R1475 T1892 T1890 pobj cells,in
R1476 T1893 T1889 punct ",",expressed
R1477 T1894 T1889 prep including,expressed
R1478 T1895 T1898 det the,antigens
R1479 T1900 T1902 amod latent,proteins
R1480 T1901 T1902 compound membrane,proteins
R1481 T1896 T1898 nmod EBV,antigens
R1482 T1902 T1898 conj proteins,antigens
R1483 T1903 T1889 punct ",",expressed
R1484 T1897 T1898 amod nuclear,antigens
R1485 T1904 T1904 ROOT have,have
R1486 T1905 T1906 amod profound,effects
R1487 T1906 T1904 dobj effects,have
R1488 T1898 T1894 pobj antigens,including
R1489 T1907 T1906 prep on,effects
R1490 T1908 T1909 compound cell,growth
R1491 T1909 T1910 compound growth,regulation
R1492 T1899 T1898 cc and,antigens
R1493 T1910 T1907 pobj regulation,on
R1494 T1911 T1904 cc and,have
R1495 T1912 T1913 auxpass are,required
R1496 T1913 T1904 conj required,have
R1497 T1914 T1913 prep for,required
R1498 T1915 T1917 compound EBV,infection
R1499 T1997 T1998 amod CD40,ligand
R1500 T1916 T1917 compound latent,infection
R1501 T1917 T1914 pobj infection,for
R1502 T1918 T1917 cc and,infection
R1503 T1919 T1920 compound B,cell
R1504 T1920 T1921 compound cell,transformation
R1505 T1921 T1917 conj transformation,infection
R1506 T1998 T1996 pobj ligand,with
R1507 T1922 T1924 nmod [,]
R1508 T1923 T1924 nummod 1,]
R1509 T1924 T1921 appos ],transformation
R1510 T1999 T2013 advcl expressed,acts
R1511 T1925 T1904 punct .,have
R1512 T1926 T1934 advmod Latent,considered
R1513 T1927 T1928 compound membrane,protein
R1514 T2000 T1999 prep on,expressed
R1515 T1928 T1934 nsubjpass protein,considered
R1516 T1929 T1928 nummod 1,protein
R1517 T1930 T1928 punct (,protein
R1518 T2001 T2003 amod activated,cells
R1519 T1931 T1928 appos LMP1,protein
R1520 T1932 T1928 punct ),protein
R1521 T1933 T1934 auxpass is,considered
R1522 T1934 T1934 ROOT considered,considered
R1523 T2002 T2003 compound T,cells
R1524 T1935 T1937 det the,oncoprotein
R1525 T1936 T1937 amod major,oncoprotein
R1526 T1937 T1934 oprd oncoprotein,considered
R1527 T2003 T2000 pobj cells,on
R1528 T1938 T1937 prep of,oncoprotein
R1529 T1939 T1938 pobj EBV,of
R1530 T1940 T1934 punct ",",considered
R1531 T2004 T2005 aux to,induce
R1532 T1941 T1943 mark as,transforms
R1533 T1942 T1943 nsubj it,transforms
R1534 T1943 T1934 advcl transforms,considered
R1535 T2005 T1999 xcomp induce,expressed
R1536 T1944 T1945 compound rodent,fibroblasts
R1537 T1945 T1943 dobj fibroblasts,transforms
R1538 T1946 T1943 prep to,transforms
R1539 T2006 T2008 compound B,activation
R1540 T1947 T1946 pobj tumorigenicity,to
R1541 T2007 T2008 compound cell,activation
R1542 T1948 T1947 prep in,tumorigenicity
R1543 T2008 T2005 dobj activation,induce
R1544 T1949 T1950 amod nude,mice
R1545 T1950 T1948 pobj mice,in
R1546 T1951 T1943 cc and,transforms
R1547 T2009 T2008 cc and,activation
R1548 T1952 T1953 auxpass is,expressed
R1549 T1953 T1943 conj expressed,transforms
R1550 T1954 T1953 prep in,expressed
R1551 T2010 T2008 conj differentiation,activation
R1552 T1955 T1954 pobj HD,in
R1553 T1956 T1955 punct ",",HD
R1554 T2011 T2013 punct ",",acts
R1555 T1957 T1955 conj NPC,HD
R1556 T1958 T1957 punct ",",NPC
R1557 T1959 T1957 cc and,NPC
R1558 T2012 T2013 nsubj LMP1,acts
R1559 T1960 T1961 compound immunosuppression-associated,tumors
R1560 T1961 T1957 conj tumors,NPC
R1561 T1962 T1943 conj [,transforms
R1562 T2013 T2013 ROOT acts,acts
R1563 T1963 T1962 nummod 4,[
R1564 T2014 T2013 prep as,acts
R1565 T1964 T1965 nummod 8,]
R1566 T2015 T2017 det a,signal
R1567 T1965 T1962 appos ],[
R1568 T1966 T1934 punct .,considered
R1569 T2016 T2017 amod constitutive,signal
R1570 T1967 T1972 prep In,mimics
R1571 T1968 T1969 compound B,lymphocytes
R1572 T2017 T2014 pobj signal,as
R1573 T1969 T1967 pobj lymphocytes,In
R1574 T1970 T1972 punct ",",mimics
R1575 T1971 T1972 nsubj LMP1,mimics
R1576 T2018 T2017 prep through,signal
R1577 T1972 T1972 ROOT mimics,mimics
R1578 T1973 T1972 dobj CD40,mimics
R1579 T1974 T1972 advcl signaling,mimics
R1580 T2019 T2020 amod ligand-independent,oligomerization
R1581 T1975 T1974 punct ",",signaling
R1582 T1976 T1972 cc and,mimics
R1583 T1977 T1978 det both,LMP1
R1584 T1978 T1981 nsubj LMP1,are
R1585 T2020 T2018 pobj oligomerization,through
R1586 T1979 T1978 cc and,LMP1
R1587 T1980 T1978 conj CD40,LMP1
R1588 T1981 T1972 conj are,mimics
R1589 T2021 T2013 punct .,acts
R1590 T1982 T1981 acomp essential,are
R1591 T1983 T1982 prep for,essential
R1592 T1984 T1987 amod EBV-mediated,transformation
R1593 T2022 T2025 nummod LMP1,interact
R1594 T1985 T1986 compound B,cell
R1595 T1986 T1987 compound cell,transformation
R1596 T1987 T1983 pobj transformation,for
R1597 T1988 T1983 dep [,for
R1598 T1989 T1988 nummod 9,[
R1599 T1990 T1991 nummod 11,]
R1600 T1991 T1988 appos ],[
R1601 T2023 T2022 cc and,LMP1
R1602 T1992 T1981 punct .,are
R1603 T1993 T1999 mark While,expressed
R1604 T1994 T1995 nummod CD40,interacts
R1605 T2024 T2022 conj CD40,LMP1
R1606 T1995 T1999 nsubj interacts,expressed
R1607 T1996 T1995 prep with,interacts
R1608 T2025 T2025 ROOT interact,interact
R1609 T2026 T2025 prep with,interact
R1610 T2027 T2031 det the,factor
R1611 T2028 T2031 amod same,factor
R1612 T2029 T2030 compound tumor,necrosis
R1613 T2094 T2095 punct (,PI3K
R1614 T2095 T2093 appos PI3K,kinase
R1615 T2096 T2091 punct ),phosphatidylinositol
R1616 T2030 T2031 compound necrosis,factor
R1617 T2097 T2098 compound /,Akt
R1618 T2098 T2099 nsubj Akt,signaling
R1619 T2099 T2090 advcl signaling,activates
R1620 T2031 T2026 pobj factor,with
R1621 T2100 T2099 cc and,signaling
R1622 T2101 T2105 mark that,required
R1623 T2032 T2060 nmod receptor,]
R1624 T2102 T2103 det this,activation
R1625 T2103 T2105 nsubjpass activation,required
R1626 T2033 T2034 amod associated,factors
R1627 T2104 T2105 auxpass is,required
R1628 T2034 T2032 appos factors,receptor
R1629 T2105 T2099 conj required,signaling
R1630 T2035 T2036 punct (,TRAFs
R1631 T2036 T2034 appos TRAFs,factors
R1632 T2106 T2105 prep for,required
R1633 T2107 T2108 amod LMP1-mediated,transformation
R1634 T2037 T2034 punct ),factors
R1635 T2108 T2106 pobj transformation,for
R1636 T2109 T2108 prep of,transformation
R1637 T2110 T2111 compound rodent,fibroblasts
R1638 T2038 T2032 acl leading,receptor
R1639 T2111 T2114 compound fibroblasts,]
R1640 T2112 T2114 compound [,]
R1641 T2039 T2038 prep to,leading
R1642 T2113 T2114 compound "5,19",]
R1643 T2114 T2109 pobj ],of
R1644 T2115 T2086 punct .,indicate
R1645 T2116 T2124 prep In,maintained
R1646 T2117 T2116 pobj vitro,In
R1647 T2118 T2124 punct ",",maintained
R1648 T2040 T2039 pobj activation,to
R1649 T2119 T2121 amod primary,cells
R1650 T2120 T2121 compound B,cells
R1651 T2121 T2124 nsubjpass cells,maintained
R1652 T2041 T2040 prep of,activation
R1653 T2122 T2124 aux can,maintained
R1654 T2123 T2124 auxpass be,maintained
R1655 T2042 T2041 pobj NFκB,of
R1656 T2124 T2124 ROOT maintained,maintained
R1657 T2125 T2124 agent by,maintained
R1658 T2126 T2127 compound CD40,ligation
R1659 T2043 T2042 punct ",",NFκB
R1660 T2127 T2125 pobj ligation,by
R1661 T2128 T2127 prep in,ligation
R1662 T2129 T2128 pobj combination,in
R1663 T2044 T2046 compound c-Jun,terminal
R1664 T2130 T2124 prep with,maintained
R1665 T2131 T2132 nummod IL4,treatment
R1666 T2045 T2046 compound N,terminal
R1667 T2132 T2130 pobj treatment,with
R1668 T2133 T2124 punct .,maintained
R1669 T2134 T2139 prep In,is
R1670 T2135 T2134 pobj vivo,In
R1671 T2046 T2047 compound terminal,kinase
R1672 T2136 T2139 punct ",",is
R1673 T2137 T2138 nsubj CD40,signaling
R1674 T2047 T2042 appos kinase,NFκB
R1675 T2138 T2139 nsubj signaling,is
R1676 T2139 T2139 ROOT is,is
R1677 T2140 T2139 acomp necessary,is
R1678 T2048 T2049 punct (,JNK
R1679 T2141 T2139 prep for,is
R1680 T2142 T2143 amod germinal,center
R1681 T2143 T2141 pobj center,for
R1682 T2144 T2145 punct (,GC
R1683 T2049 T2047 appos JNK,kinase
R1684 T2145 T2143 appos GC,center
R1685 T2146 T2145 punct ),GC
R1686 T2147 T2148 npadvmod formation,such
R1687 T2050 T2049 punct ),JNK
R1688 T2148 T2139 acomp such,is
R1689 T2149 T2156 mark that,are
R1690 T2150 T2151 nsubj mice,deficient
R1691 T2051 T2032 punct ",",receptor
R1692 T2151 T2156 nsubj deficient,are
R1693 T2152 T2151 prep for,deficient
R1694 T2153 T2152 pobj CD40,for
R1695 T2154 T2153 cc or,CD40
R1696 T2155 T2153 conj CD40L,CD40
R1697 T2052 T2032 cc and,receptor
R1698 T2053 T2054 nummod p38,MAPK
R1699 T2156 T2148 acl are,such
R1700 T2157 T2156 acomp unable,are
R1701 T2054 T2032 conj MAPK,receptor
R1702 T2158 T2159 aux to,form
R1703 T2159 T2157 xcomp form,unable
R1704 T2160 T2159 dobj GCs,form
R1705 T2055 T2032 conj signaling,receptor
R1706 T2161 T2159 prep in,form
R1707 T2162 T2161 pobj response,in
R1708 T2056 T2060 nsubj pathways,]
R1709 T2163 T2162 prep to,response
R1710 T2164 T2165 compound T,cell
R1711 T2165 T2163 pobj cell,to
R1712 T2057 T2060 dep [,]
R1713 T2166 T2167 amod dependent,antigens
R1714 T2167 T2159 dobj antigens,form
R1715 T2058 T2057 nummod 12,[
R1716 T2168 T2170 compound [,]
R1717 T2169 T2170 compound "20,21",]
R1718 T2170 T2167 appos ],antigens
R1719 T2059 T2060 nummod 16,]
R1720 T2171 T2139 punct .,is
R1721 T2172 T2175 preconj Both,proximal
R1722 T2173 T2175 det the,proximal
R1723 T2060 T2031 appos ],factor
R1724 T2061 T2060 punct .,]
R1725 T2174 T2175 compound membrane,proximal
R1726 T2175 T2199 nsubj proximal,is
R1727 T2062 T2066 nsubjpass Activation,required
R1728 T2176 T2175 cc and,proximal
R1729 T2177 T2179 amod distal,regions
R1730 T2178 T2179 amod cytoplasmic,regions
R1731 T2063 T2062 prep of,Activation
R1732 T2179 T2175 conj regions,proximal
R1733 T2180 T2179 prep of,regions
R1734 T2064 T2063 pobj NFκB,of
R1735 T2181 T2180 pobj CD40,of
R1736 T2182 T2190 mark that,are
R1737 T2183 T2190 nsubj bind,are
R1738 T2065 T2066 auxpass is,required
R1739 T2066 T2066 ROOT required,required
R1740 T2184 T2183 nummod TRAF6,bind
R1741 T2067 T2066 prep for,required
R1742 T2185 T2183 cc and,bind
R1743 T2186 T2183 conj TRAFs2/3/5,bind
R1744 T2068 T2070 amod EBV-induced,cell
R1745 T2187 T2183 punct ",",bind
R1746 T2188 T2183 advmod respectively,bind
R1747 T2189 T2190 punct ",",are
R1748 T2190 T2175 acl are,proximal
R1749 T2069 T2070 compound B,cell
R1750 T2191 T2190 acomp necessary,are
R1751 T2070 T2071 compound cell,transformation
R1752 T2192 T2190 prep for,are
R1753 T2071 T2067 pobj transformation,for
R1754 T2193 T2194 compound GC,formation
R1755 T2194 T2192 pobj formation,for
R1756 T2195 T2190 punct ",",are
R1757 T2072 T2071 cc and,transformation
R1758 T2196 T2190 cc but,are
R1759 T2197 T2198 det either,region
R1760 T2198 T2199 nsubj region,is
R1761 T2073 T2074 poss its,inhibition
R1762 T2199 T2199 ROOT is,is
R1763 T2200 T2199 acomp sufficient,is
R1764 T2201 T2202 aux to,induce
R1765 T2074 T2071 conj inhibition,transformation
R1766 T2202 T2200 xcomp induce,sufficient
R1767 T2203 T2206 amod extrafollicular,differentiation
R1768 T2204 T2205 compound B,cell
R1769 T2075 T2076 advmod rapidly,results
R1770 T2205 T2206 compound cell,differentiation
R1771 T2076 T2066 advcl results,required
R1772 T2206 T2202 dobj differentiation,induce
R1773 T2207 T2202 cc and,induce
R1774 T2208 T2202 conj restore,induce
R1775 T2209 T2212 amod low,production
R1776 T2077 T2076 prep in,results
R1777 T2210 T2211 compound affinity,antibody
R1778 T2211 T2212 compound antibody,production
R1779 T2212 T2208 dobj production,restore
R1780 T2078 T2079 compound cell,death
R1781 T2213 T2215 nmod [,]
R1782 T2214 T2215 nummod 22,]
R1783 T2215 T2212 nmod ],production
R1784 T2079 T2077 pobj death,in
R1785 T2216 T2199 punct .,is
R1786 T2217 T2221 advmod Functionally,rescue
R1787 T2218 T2221 punct ",",rescue
R1788 T2080 T2082 compound [,]
R1789 T2219 T2221 nsubj LMP1,rescue
R1790 T2220 T2221 aux can,rescue
R1791 T2221 T2221 ROOT rescue,rescue
R1792 T2081 T2082 compound "17,18",]
R1793 T2222 T2223 amod CD40-deficient,mice
R1794 T2223 T2221 dobj mice,rescue
R1795 T2224 T2221 cc and,rescue
R1796 T2225 T2221 conj restore,rescue
R1797 T2226 T2231 compound immunoglobulin,switching
R1798 T2227 T2230 punct (,class
R1799 T2082 T2076 appos ],results
R1800 T2228 T2230 nmod Ig,class
R1801 T2229 T2230 punct ),class
R1802 T2230 T2231 compound class,switching
R1803 T2231 T2225 dobj switching,restore
R1804 T2083 T2066 punct .,required
R1805 T2232 T2234 punct ",",likely
R1806 T2233 T2234 advmod most,likely
R1807 T2234 T2225 conj likely,restore
R1808 T2235 T2237 mark because,recruits
R1809 T2084 T2085 amod Recent,studies
R1810 T2236 T2237 nummod LMP1,recruits
R1811 T2237 T2234 advcl recruits,likely
R1812 T2238 T2240 amod similar,molecules
R1813 T2239 T2240 compound TRAF,molecules
R1814 T2085 T2086 nsubj studies,indicate
R1815 T2240 T2237 dobj molecules,recruits
R1816 T2241 T2237 punct ",",recruits
R1817 T2242 T2237 appos TRAFs,recruits
R1818 T2086 T2086 ROOT indicate,indicate
R1819 T2243 T2244 nummod 1/2/3,/
R1820 T2244 T2242 dobj /,TRAFs
R1821 T2245 T2244 nummod 5,/
R1822 T2087 T2090 mark that,activates
R1823 T2246 T2244 cc and,/
R1824 T2247 T2244 conj TRAF6,/
R1825 T2248 T2247 punct ",",TRAF6
R1826 T2088 T2090 nsubj LMP1,activates
R1827 T2249 T2244 prep through,/
R1828 T2250 T2253 det the,regions
R1829 T2251 T2253 amod C-terminal,regions
R1830 T2089 T2090 advmod also,activates
R1831 T2252 T2253 compound activation,regions
R1832 T2253 T2249 pobj regions,through
R1833 T2254 T2253 nummod 1,regions
R1834 T2090 T2086 ccomp activates,indicate
R1835 T2255 T2253 cc and,regions
R1836 T2256 T2257 nummod 2,domains
R1837 T2091 T2090 dobj phosphatidylinositol,activates
R1838 T2092 T2093 nummod 3,kinase
R1839 T2257 T2253 conj domains,regions
R1840 T2258 T2257 punct ",",domains
R1841 T2259 T2237 advmod respectively,recruits
R1842 T2093 T2091 appos kinase,phosphatidylinositol
R1843 T2260 T2221 punct .,rescue
R1844 T2261 T2264 advmod However,is
R1845 T2288 T2283 punct ",",studied
R1846 T2262 T2264 punct ",",is
R1847 T2263 T2264 nsubj LMP1,is
R1848 T2264 T2264 ROOT is,is
R1849 T2265 T2264 acomp unable,is
R1850 T2289 T2283 advmod however,studied
R1851 T2266 T2267 aux to,restore
R1852 T2267 T2265 xcomp restore,unable
R1853 T2268 T2269 compound affinity,maturation
R1854 T2269 T2267 dobj maturation,restore
R1855 T2290 T2283 punct ",",studied
R1856 T2270 T2269 cc and,maturation
R1857 T2271 T2272 compound GC,formation
R1858 T2291 T2292 advmod only,LMP1
R1859 T2272 T2269 conj formation,maturation
R1860 T2273 T2275 nmod [,]
R1861 T2274 T2275 nummod 23,]
R1862 T2292 T2293 nsubj LMP1,induces
R1863 T2275 T2264 dobj ],is
R1864 T2276 T2264 punct .,is
R1865 T2277 T2280 amod Several,proteins
R1866 T2293 T2283 conj induces,studied
R1867 T2278 T2280 nmod EBV,proteins
R1868 T2279 T2280 amod transforming,proteins
R1869 T2280 T2283 nsubjpass proteins,studied
R1870 T2294 T2295 compound tumor,development
R1871 T2281 T2283 aux have,studied
R1872 T2282 T2283 auxpass been,studied
R1873 T2295 T2293 dobj development,induces
R1874 T2283 T2283 ROOT studied,studied
R1875 T2284 T2283 prep in,studied
R1876 T2285 T2287 amod transgenic,models
R1877 T2296 T2297 advmod when,expressed
R1878 T2286 T2287 compound mouse,models
R1879 T2287 T2284 pobj models,in
R1880 T2297 T2293 advcl expressed,induces
R1881 T2298 T2297 prep under,expressed
R1882 T2299 T2300 det the,control
R1883 T2300 T2298 pobj control,under
R1884 T2354 T2350 punct ),mice
R1885 T2301 T2300 prep of,control
R1886 T2355 T2321 punct ",",express
R1887 T2356 T2321 advcl suggesting,express
R1888 T2357 T2359 mark that,contributes
R1889 T2302 T2306 det the,promoter
R1890 T2358 T2359 nsubj LMP1,contributes
R1891 T2359 T2356 ccomp contributes,suggesting
R1892 T2360 T2359 prep to,contributes
R1893 T2303 T2306 nmod Ig,promoter
R1894 T2361 T2362 compound tumor,development
R1895 T2362 T2360 pobj development,to
R1896 T2363 T2365 nmod [,]
R1897 T2364 T2365 nummod 26,]
R1898 T2365 T2362 appos ],development
R1899 T2366 T2321 punct .,express
R1900 T2367 T2369 det The,lymphomas
R1901 T2304 T2306 amod heavy,promoter
R1902 T2368 T2369 compound LMP1,lymphomas
R1903 T2369 T2371 nsubj lymphomas,rearranged
R1904 T2370 T2371 aux have,rearranged
R1905 T2305 T2306 compound chain,promoter
R1906 T2371 T2371 ROOT rearranged,rearranged
R1907 T2372 T2373 compound Ig,genes
R1908 T2373 T2371 dobj genes,rearranged
R1909 T2306 T2301 pobj promoter,of
R1910 T2374 T2371 cc and,rearranged
R1911 T2375 T2376 aux have,activated
R1912 T2376 T2371 conj activated,rearranged
R1913 T2307 T2306 cc and,promoter
R1914 T2377 T2376 dobj Akt,activated
R1915 T2378 T2377 punct ",",Akt
R1916 T2379 T2377 conj JNK,Akt
R1917 T2308 T2309 compound enhancer,[
R1918 T2380 T2379 punct ",",JNK
R1919 T2381 T2379 appos p38,JNK
R1920 T2382 T2379 punct ",",JNK
R1921 T2309 T2300 appos [,control
R1922 T2383 T2379 cc and,JNK
R1923 T2384 T2379 conj NFκB,JNK
R1924 T2310 T2309 nummod 24,[
R1925 T2311 T2312 nummod 26,]
R1926 T2312 T2300 appos ],control
R1927 T2385 T2376 punct ",",activated
R1928 T2386 T2376 prep with,activated
R1929 T2313 T2293 punct .,induces
R1930 T2387 T2388 amod specific,activation
R1931 T2388 T2386 pobj activation,with
R1932 T2389 T2388 prep of,activation
R1933 T2314 T2317 det The,mice
R1934 T2390 T2393 det the,member
R1935 T2391 T2393 compound NFκB,member
R1936 T2392 T2393 compound family,member
R1937 T2393 T2389 pobj member,of
R1938 T2315 T2317 compound LMP1,mice
R1939 T2394 T2395 compound cRel,[
R1940 T2395 T2376 dobj [,activated
R1941 T2316 T2317 compound transgenic,mice
R1942 T2396 T2397 nummod 27,]
R1943 T2397 T2395 appos ],[
R1944 T2398 T2371 punct .,rearranged
R1945 T2317 T2321 nsubj mice,express
R1946 T2399 T2411 prep In,characterized
R1947 T2400 T2401 det this,study
R1948 T2401 T2399 pobj study,In
R1949 T2402 T2411 punct ",",characterized
R1950 T2403 T2406 det the,lymphocytes
R1951 T2404 T2406 compound LMP1,lymphocytes
R1952 T2318 T2319 punct (,IgLMP1
R1953 T2405 T2406 compound transgenic,lymphocytes
R1954 T2406 T2411 nsubjpass lymphocytes,characterized
R1955 T2407 T2406 cc and,lymphocytes
R1956 T2408 T2406 conj lymphomas,lymphocytes
R1957 T2319 T2317 appos IgLMP1,mice
R1958 T2409 T2411 auxpass were,characterized
R1959 T2410 T2411 advmod further,characterized
R1960 T2411 T2411 ROOT characterized,characterized
R1961 T2320 T2317 punct ),mice
R1962 T2412 T2411 cc and,characterized
R1963 T2413 T2415 poss their,properties
R1964 T2414 T2415 compound growth,properties
R1965 T2321 T2321 ROOT express,express
R1966 T2415 T2419 nsubjpass properties,determined
R1967 T2416 T2415 prep in,properties
R1968 T2322 T2321 dobj LMP1,express
R1969 T2417 T2416 pobj vitro,in
R1970 T2323 T2322 prep in,LMP1
R1971 T2418 T2419 auxpass were,determined
R1972 T2324 T2325 compound B,lymphocytes
R1973 T2419 T2411 conj determined,characterized
R1974 T2420 T2419 punct .,determined
R1975 T2421 T2422 aux To,obtain
R1976 T2325 T2323 pobj lymphocytes,in
R1977 T2422 T2441 advcl obtain,inoculated
R1978 T2423 T2424 amod pure,populations
R1979 T2424 T2422 dobj populations,obtain
R1980 T2326 T2321 punct ",",express
R1981 T2425 T2424 prep of,populations
R1982 T2426 T2427 amod malignant,lymphocytes
R1983 T2327 T2321 cc and,express
R1984 T2427 T2425 pobj lymphocytes,of
R1985 T2428 T2422 cc and,obtain
R1986 T2328 T2336 prep in,develops
R1987 T2429 T2430 aux to,enable
R1988 T2430 T2422 conj enable,obtain
R1989 T2431 T2432 advmod more,detailed
R1990 T2329 T2328 pobj mice,in
R1991 T2432 T2434 amod detailed,analyses
R1992 T2433 T2434 compound biochemical,analyses
R1993 T2434 T2430 dobj analyses,enable
R1994 T2330 T2336 advcl older,develops
R1995 T2435 T2434 punct ",",analyses
R1996 T2436 T2434 conj examples,analyses
R1997 T2437 T2434 prep of,analyses
R1998 T2438 T2439 amod primary,lymphomas
R1999 T2439 T2437 pobj lymphomas,of
R2000 T2440 T2441 auxpass were,inoculated
R2001 T2331 T2336 prep than,develops
R2002 T2441 T2441 ROOT inoculated,inoculated
R2003 T2442 T2441 cc and,inoculated
R2004 T2443 T2441 conj passaged,inoculated
R2005 T2332 T2333 nummod 12,mo
R2006 T2444 T2443 prep in,passaged
R2007 T2445 T2446 compound SCID,mice
R2008 T2446 T2444 pobj mice,in
R2009 T2333 T2331 pobj mo,than
R2010 T2447 T2441 punct .,inoculated
R2011 T2448 T2453 advmod Interestingly,restricted
R2012 T2449 T2453 punct ",",restricted
R2013 T2334 T2336 punct ",",develops
R2014 T2450 T2451 compound lymphoma,development
R2015 T2335 T2336 nsubj lymphoma,develops
R2016 T2336 T2321 conj develops,express
R2017 T2451 T2453 nsubjpass development,restricted
R2018 T2337 T2336 prep with,develops
R2019 T2338 T2339 amod increased,incidence
R2020 T2452 T2453 auxpass was,restricted
R2021 T2339 T2337 pobj incidence,with
R2022 T2453 T2453 ROOT restricted,restricted
R2023 T2454 T2453 prep to,restricted
R2024 T2340 T2339 punct (,incidence
R2025 T2455 T2456 amod B-1a,lymphocytes
R2026 T2456 T2454 pobj lymphocytes,to
R2027 T2457 T2456 punct ",",lymphocytes
R2028 T2341 T2342 nummod 40,%
R2029 T2458 T2460 det a,population
R2030 T2459 T2460 amod self-replenishing,population
R2031 T2460 T2453 dobj population,restricted
R2032 T2342 T2339 appos %,incidence
R2033 T2461 T2460 prep of,population
R2034 T2462 T2461 pobj cells,of
R2035 T2343 T2344 nummod 50,%
R2036 T2463 T2464 nsubj that,are
R2037 T2464 T2462 relcl are,cells
R2038 T2465 T2464 acomp prone,are
R2039 T2344 T2339 appos %,incidence
R2040 T2466 T2467 aux to,malignancy
R2041 T2467 T2465 xcomp malignancy,prone
R2042 T2468 T2470 compound [,]
R2043 T2345 T2336 punct ),develops
R2044 T2469 T2470 compound "28,29",]
R2045 T2470 T2467 dobj ],malignancy
R2046 T2471 T2453 punct .,restricted
R2047 T2472 T2474 nummod LMP1,lymphocytes
R2048 T2473 T2474 amod transgenic,lymphocytes
R2049 T2474 T2476 nsubj lymphocytes,increased
R2050 T2346 T2321 prep compared,express
R2051 T2475 T2476 aux had,increased
R2052 T2476 T2476 ROOT increased,increased
R2053 T2477 T2476 dobj viability,increased
R2054 T2347 T2346 prep to,compared
R2055 T2478 T2476 prep in,increased
R2056 T2479 T2481 amod vitro,viability
R2057 T2480 T2479 cc and,vitro
R2058 T2348 T2350 amod wild-type,mice
R2059 T2481 T2478 pobj viability,in
R2060 T2349 T2350 compound control,mice
R2061 T2350 T2347 pobj mice,to
R2062 T2482 T2483 auxpass was,increased
R2063 T2483 T2476 conj increased,increased
R2064 T2484 T2483 agent by,increased
R2065 T2351 T2350 punct (,mice
R2066 T2485 T2486 det the,addition
R2067 T2486 T2484 pobj addition,by
R2068 T2487 T2486 prep of,addition
R2069 T2352 T2353 nummod 11,%
R2070 T2488 T2487 pobj IL4,of
R2071 T2489 T2476 punct .,increased
R2072 T2490 T2500 prep In,were
R2073 T2353 T2350 appos %,mice
R2074 T2491 T2490 pobj contrast,In
R2075 T2492 T2500 punct ",",were
R2076 T2548 T2547 punct ",",NFκB
R2077 T2493 T2494 preconj both,LMP1-positive
R2078 T2494 T2499 amod LMP1-positive,cells
R2079 T2495 T2494 cc and,LMP1-positive
R2080 T2496 T2497 punct -,negative
R2081 T2549 T2547 cc and,NFκB
R2082 T2497 T2494 conj negative,LMP1-positive
R2083 T2550 T2552 amod Stat3,pathways
R2084 T2498 T2499 compound lymphoma,cells
R2085 T2499 T2500 nsubj cells,were
R2086 T2500 T2500 ROOT were,were
R2087 T2551 T2552 compound signaling,pathways
R2088 T2501 T2500 acomp independent,were
R2089 T2502 T2501 prep of,independent
R2090 T2552 T2553 nsubj pathways,blocked
R2091 T2503 T2504 nummod IL4,co-stimulation
R2092 T2504 T2502 pobj co-stimulation,of
R2093 T2505 T2504 prep for,co-stimulation
R2094 T2553 T2553 ROOT blocked,blocked
R2095 T2506 T2505 pobj survival,for
R2096 T2507 T2506 cc and,survival
R2097 T2554 T2556 det the,growth
R2098 T2508 T2506 conj proliferation,survival
R2099 T2509 T2500 prep in,were
R2100 T2510 T2509 pobj vitro,in
R2101 T2511 T2500 prep with,were
R2102 T2512 T2514 det a,absence
R2103 T2513 T2514 amod complete,absence
R2104 T2555 T2556 amod enhanced,growth
R2105 T2514 T2511 pobj absence,with
R2106 T2515 T2514 prep of,absence
R2107 T2516 T2517 amod activated,Stat6
R2108 T2556 T2553 dobj growth,blocked
R2109 T2517 T2515 pobj Stat6,of
R2110 T2518 T2517 punct ",",Stat6
R2111 T2519 T2521 det the,target
R2112 T2520 T2521 compound IL4,target
R2113 T2557 T2556 prep of,growth
R2114 T2521 T2517 appos target,Stat6
R2115 T2522 T2500 punct .,were
R2116 T2558 T2563 det both,lymphocytes
R2117 T2523 T2524 det The,lymphomas
R2118 T2524 T2527 nsubjpass lymphomas,distinguished
R2119 T2525 T2527 auxpass were,distinguished
R2120 T2526 T2527 advmod also,distinguished
R2121 T2559 T2563 nummod LMP1,lymphocytes
R2122 T2527 T2527 ROOT distinguished,distinguished
R2123 T2528 T2527 agent by,distinguished
R2124 T2529 T2530 amod constitutive,activation
R2125 T2560 T2563 nmod transgenic,lymphocytes
R2126 T2530 T2528 pobj activation,by
R2127 T2531 T2530 prep of,activation
R2128 T2532 T2531 pobj Stat3,of
R2129 T2561 T2560 cc and,transgenic
R2130 T2533 T2530 cc and,activation
R2131 T2534 T2530 conj deregulation,activation
R2132 T2535 T2530 prep of,activation
R2133 T2562 T2560 conj malignant,transgenic
R2134 T2536 T2540 det the,pathway
R2135 T2537 T2539 compound Rb,cycle
R2136 T2538 T2539 compound cell,cycle
R2137 T2563 T2557 pobj lymphocytes,of
R2138 T2539 T2540 compound cycle,pathway
R2139 T2540 T2535 pobj pathway,of
R2140 T2541 T2527 punct .,distinguished
R2141 T2564 T2553 punct ",",blocked
R2142 T2542 T2552 nmod Inhibition,pathways
R2143 T2543 T2542 prep of,Inhibition
R2144 T2544 T2545 det the,PI3K/Akt
R2145 T2565 T2553 advcl suggesting,blocked
R2146 T2566 T2570 mark that,required
R2147 T2545 T2543 pobj PI3K/Akt,of
R2148 T2546 T2545 punct ",",PI3K/Akt
R2149 T2547 T2545 conj NFκB,PI3K/Akt
R2150 T2567 T2568 det these,pathways
R2151 T2568 T2570 nsubjpass pathways,required
R2152 T2569 T2570 auxpass are,required
R2153 T2579 T2580 aux to,be
R2154 T2580 T2578 xcomp be,appear
R2155 T2570 T2565 ccomp required,suggesting
R2156 T2581 T2583 det the,targets
R2157 T2582 T2583 amod same,targets
R2158 T2583 T2580 attr targets,be
R2159 T2571 T2570 prep for,required
R2160 T2584 T2586 nsubjpass that,deregulated
R2161 T2585 T2586 auxpass are,deregulated
R2162 T2572 T2573 poss their,growth
R2163 T2586 T2583 relcl deregulated,targets
R2164 T2587 T2586 prep in,deregulated
R2165 T2588 T2590 amod wild-type,lymphomas
R2166 T2573 T2571 pobj growth,for
R2167 T2589 T2590 compound B-1a,lymphomas
R2168 T2590 T2587 pobj lymphomas,in
R2169 T2591 T2592 nsubj that,arise
R2170 T2592 T2590 relcl arise,lymphomas
R2171 T2574 T2573 cc and,growth
R2172 T2593 T2592 advmod spontaneously,arise
R2173 T2594 T2592 prep through,arise
R2174 T2595 T2596 compound age,predisposition
R2175 T2575 T2573 conj survival,growth
R2176 T2596 T2594 pobj predisposition,through
R2177 T2597 T2578 punct .,appear
R2178 T2576 T2553 punct .,blocked
R2179 T2598 T2599 det This,study
R2180 T2599 T2600 nsubj study,reveals
R2181 T2600 T2600 ROOT reveals,reveals
R2182 T2601 T2603 mark that,promotes
R2183 T2602 T2603 nsubj LMP1,promotes
R2184 T2603 T2600 ccomp promotes,reveals
R2185 T2577 T2578 nsubj These,appear
R2186 T2604 T2603 dobj malignancy,promotes
R2187 T2605 T2603 prep in,promotes
R2188 T2606 T2605 pobj cells,in
R2189 T2578 T2578 ROOT appear,appear
R2190 T2607 T2606 prep with,cells
R2191 T2608 T2610 det the,ability
R2192 T2609 T2610 amod inherent,ability
R2194 T2610 T2607 pobj ability,with
R2195 T2611 T2612 aux to,proliferate
R2196 T2612 T2610 acl proliferate,ability
R2197 T2613 T2603 cc and,promotes
R2198 T2614 T2625 mark that,required
R2199 T2615 T2616 det the,Akt
R2200 T2616 T2623 nmod Akt,pathways
R2201 T2617 T2616 punct ",",Akt
R2202 T2618 T2616 conj NFκB,Akt
R2203 T2619 T2618 punct ",",NFκB
R2204 T2620 T2618 cc and,NFκB
R2205 T2621 T2623 amod Stat3,pathways
R2206 T2622 T2623 compound signaling,pathways
R2207 T2623 T2625 nsubjpass pathways,required
R2208 T2624 T2625 auxpass are,required
R2209 T2625 T2603 conj required,promotes
R2210 T2626 T2625 prep for,required
R2211 T2627 T2630 poss its,effects
R2212 T2628 T2630 nmod growth,effects
R2213 T2629 T2630 amod stimulatory,effects
R2214 T2630 T2626 pobj effects,for
R2215 T2631 T2600 punct .,reveals
R2749 T3518 T3519 compound High,Levels
R2750 T3519 T3535 nsubjpass Levels,directed
R2751 T3520 T3519 prep of,Levels
R2752 T3521 T3523 compound LMP1,Correlates
R2753 T3522 T3523 compound Expression,Correlates
R2754 T3523 T3520 pobj Correlates,of
R2755 T3524 T3519 prep with,Levels
R2756 T3525 T3526 det the,Development
R2757 T3526 T3524 pobj Development,with
R2758 T3527 T3526 prep of,Development
R2759 T3528 T3529 compound Lymphoma,LMP1
R2760 T3529 T3530 compound LMP1,expression
R2761 T3530 T3527 pobj expression,of
R2762 T3531 T3519 prep in,Levels
R2763 T3532 T3533 compound IgLMP1,mice
R2764 T3533 T3531 pobj mice,in
R2765 T3534 T3535 auxpass was,directed
R2766 T3535 T3535 ROOT directed,directed
R2767 T3536 T3535 prep to,directed
R2768 T3537 T3536 pobj B,to
R2769 T3538 T3537 dobj cells,B
R2770 T3539 T3535 prep under,directed
R2771 T3540 T3541 det the,control
R2772 T3541 T3539 pobj control,under
R2773 T3542 T3541 prep of,control
R2774 T3543 T3547 det the,promoter
R2775 T3544 T3547 nmod Ig,promoter
R2776 T3545 T3547 amod heavy,promoter
R2777 T3546 T3547 compound chain,promoter
R2778 T3547 T3542 pobj promoter,of
R2779 T3548 T3547 cc and,promoter
R2780 T3549 T3547 conj enhancer,promoter
R2781 T3550 T3535 punct .,directed
R2782 T3551 T3555 nsubj It,shown
R2783 T3552 T3555 aux has,shown
R2784 T3553 T3555 advmod previously,shown
R2785 T3554 T3555 auxpass been,shown
R2786 T3555 T3555 ROOT shown,shown
R2787 T3556 T3565 mark that,restricted
R2788 T3557 T3565 prep in,restricted
R2789 T3558 T3560 det these,mice
R2790 T3559 T3560 amod transgenic,mice
R2791 T3560 T3557 pobj mice,in
R2792 T3561 T3565 punct ",",restricted
R2793 T3562 T3563 compound LMP1,expression
R2794 T3563 T3565 nsubjpass expression,restricted
R2795 T3564 T3565 auxpass was,restricted
R2796 T3565 T3555 ccomp restricted,shown
R2797 T3566 T3565 prep to,restricted
R2798 T3567 T3570 compound B220,cells
R2799 T3568 T3569 compound +,B
R2800 T3569 T3570 compound B,cells
R2801 T3570 T3566 pobj cells,to
R2802 T3571 T3570 prep with,cells
R2803 T3572 T3571 pobj lymphoma,with
R2804 T3573 T3570 acl detected,cells
R2805 T3574 T3573 prep in,detected
R2806 T3575 T3576 advmod greatly,enlarged
R2807 T3576 T3577 amod enlarged,spleens
R2808 T3577 T3574 pobj spleens,in
R2809 T3578 T3580 compound [,]
R2810 T3579 T3580 compound "23,26",]
R2811 T3580 T3570 appos ],cells
R2812 T3581 T3555 punct .,shown
R2813 T3582 T3583 aux To,investigate
R2814 T3583 T3595 advcl investigate,purified
R2815 T3584 T3587 mark whether,contributes
R2816 T3585 T3586 compound LMP1,expression
R2817 T3586 T3587 nsubj expression,contributes
R2818 T3587 T3583 ccomp contributes,investigate
R2819 T3588 T3587 prep to,contributes
R2820 T3589 T3595 advcl lymphoma,purified
R2821 T3590 T3589 dobj development,lymphoma
R2822 T3591 T3595 punct ",",purified
R2823 T3592 T3593 compound B,cells
R2824 T3593 T3595 nsubjpass cells,purified
R2825 T3594 T3595 auxpass were,purified
R2826 T3595 T3595 ROOT purified,purified
R2827 T3596 T3595 prep from,purified
R2828 T3597 T3596 pobj splenocytes,from
R2829 T3598 T3595 agent by,purified
R2830 T3599 T3600 amod positive,selection
R2831 T3600 T3598 pobj selection,by
R2832 T3601 T3595 advcl using,purified
R2833 T3602 T3605 amod anti-CD19,beads
R2834 T3603 T3605 nmod MACS,beads
R2835 T3604 T3605 amod magnetic,beads
R2836 T3605 T3601 dobj beads,using
R2837 T3606 T3605 punct ",",beads
R2838 T3607 T3605 cc and,beads
R2839 T3608 T3609 amod equivalent,amounts
R2840 T3609 T3605 conj amounts,beads
R2841 T3610 T3609 prep of,amounts
R2842 T3611 T3612 compound B,cells
R2843 T3612 T3610 pobj cells,of
R2844 T3613 T3614 auxpass were,analyzed
R2845 T3614 T3595 conj analyzed,purified
R2846 T3615 T3614 agent by,analyzed
R2847 T3616 T3615 pobj immunoblotting,by
R2848 T3617 T3595 punct .,purified
R2849 T3618 T3619 nsubj LMP1,was
R2850 T3619 T3635 ccomp was,was
R2851 T3620 T3619 acomp detectable,was
R2852 T3621 T3620 prep in,detectable
R2853 T3622 T3625 nummod LMP1,cells
R2854 T3623 T3625 amod transgenic,cells
R2855 T3624 T3625 compound B,cells
R2856 T3625 T3621 pobj cells,in
R2857 T3626 T3619 punct ",",was
R2858 T3627 T3619 cc but,was
R2859 T3628 T3619 conj upon,was
R2860 T3629 T3628 pobj development,upon
R2861 T3630 T3629 prep of,development
R2862 T3631 T3630 pobj lymphoma,of
R2863 T3632 T3635 punct ",",was
R2864 T3633 T3634 compound LMP1,expression
R2865 T3634 T3635 nsubj expression,was
R2866 T3635 T3635 ROOT was,was
R2867 T3636 T3635 acomp stronger,was
R2868 T3637 T3636 prep in,stronger
R2869 T3638 T3639 nummod 5/7,lymphomas
R2870 T3639 T3637 pobj lymphomas,in
R2871 T3640 T3635 conj analyzed,was
R2872 T3641 T3640 prep with,analyzed
R2873 T3642 T3643 amod concomitant,appearance
R2874 T3643 T3641 pobj appearance,with
R2875 T3644 T3643 prep of,appearance
R2876 T3645 T3646 compound degradation,products
R2877 T3646 T3644 pobj products,of
R2878 T3647 T3648 punct (,Figure
R2879 T3648 T3646 appos Figure,products
R2880 T3649 T3648 nummod 1A,Figure
R2881 T3650 T3648 punct ),Figure
R2882 T3651 T3635 punct .,was
R2883 T3652 T3653 aux To,determine
R2884 T3653 T3678 advcl determine,evaluated
R2885 T3654 T3660 mark whether,detected
R2886 T3655 T3657 det the,level
R2887 T3656 T3657 amod higher,level
R2888 T3657 T3660 nsubj level,detected
R2889 T3658 T3657 prep of,level
R2890 T3659 T3658 pobj LMP1,of
R2891 T3660 T3661 csubj detected,was
R2892 T3661 T3653 ccomp was,determine
R2893 T3662 T3661 acomp due,was
R2894 T3663 T3662 prep to,due
R2895 T3664 T3665 det an,expansion
R2896 T3665 T3663 pobj expansion,to
R2897 T3666 T3665 prep of,expansion
R2898 T3667 T3668 amod malignant,lymphocytes
R2899 T3668 T3666 pobj lymphocytes,of
R2900 T3669 T3668 punct ",",lymphocytes
R2901 T3670 T3665 conj expression,expansion
R2902 T3671 T3670 prep of,expression
R2903 T3672 T3671 pobj LMP1,of
R2904 T3673 T3665 prep in,expansion
R2905 T3674 T3675 det the,spleen
R2906 T3675 T3673 pobj spleen,in
R2907 T3676 T3678 auxpass was,evaluated
R2908 T3677 T3678 advmod further,evaluated
R2909 T3678 T3678 ROOT evaluated,evaluated
R2910 T3679 T3678 agent by,evaluated
R2911 T3680 T3681 amod immunohistochemical,staining
R2912 T3681 T3679 pobj staining,by
R2913 T3682 T3678 punct .,evaluated
R2914 T3683 T3684 compound Immunohistochemistry,analysis
R2915 T3684 T3688 nsubj analysis,detected
R2916 T3685 T3684 prep of,analysis
R2917 T3686 T3687 amod spleen,sections
R2918 T3687 T3685 pobj sections,of
R2919 T3688 T3688 ROOT detected,detected
R2920 T3689 T3688 dobj LMP1,detected
R2921 T3690 T3689 prep in,LMP1
R2922 T3691 T3693 det the,membrane
R2923 T3692 T3693 compound plasma,membrane
R2924 T3693 T3690 pobj membrane,in
R2925 T3694 T3693 prep of,membrane
R2926 T3695 T3694 pobj cells,of
R2927 T3696 T3689 prep in,LMP1
R2928 T3697 T3701 preconj both,pulp
R2929 T3698 T3701 det the,pulp
R2930 T3699 T3701 amod follicular,pulp
R2931 T3700 T3701 amod white,pulp
R2932 T3701 T3696 pobj pulp,in
R2933 T3702 T3701 cc and,pulp
R2934 T3703 T3701 conj circulating,pulp
R2935 T3704 T3703 dobj lymphocytes,circulating
R2936 T3705 T3703 prep in,circulating
R2937 T3706 T3708 det the,pulp
R2938 T3707 T3708 amod red,pulp
R2939 T3708 T3705 pobj pulp,in
R2940 T3709 T3711 punct (,1B
R2941 T3710 T3711 compound Figure,1B
R2942 T3711 T3708 appos 1B,pulp
R2943 T3712 T3688 punct ),detected
R2944 T3713 T3688 punct .,detected
R2945 T3714 T3715 nummod LMP1,expression
R2946 T3715 T3716 nsubj expression,was
R2947 T3716 T3716 ROOT was,was
R2948 T3717 T3716 acomp heterogeneous,was
R2949 T3718 T3717 prep with,heterogeneous
R2950 T3719 T3721 amod strong,staining
R2951 T3720 T3721 compound LMP1,staining
R2952 T3721 T3718 pobj staining,with
R2953 T3722 T3721 xcomp interspersed,staining
R2954 T3723 T3722 prep amongst,interspersed
R2955 T3724 T3725 det a,background
R2956 T3725 T3723 pobj background,amongst
R2957 T3726 T3725 prep of,background
R2958 T3727 T3726 pobj cells,of
R2959 T3728 T3727 acl staining,cells
R2960 T3729 T3728 advmod weakly,staining
R2961 T3730 T3728 prep for,staining
R2962 T3731 T3730 pobj LMP1,for
R2963 T3732 T3716 punct .,was
R2964 T3733 T3740 prep Upon,was
R2965 T3734 T3733 pobj development,Upon
R2966 T3735 T3734 prep to,development
R2967 T3736 T3735 pobj lymphoma,to
R2968 T3737 T3740 punct ",",was
R2969 T3738 T3739 compound LMP1,expression
R2970 T3739 T3740 nsubj expression,was
R2971 T3740 T3740 ROOT was,was
R2972 T3741 T3742 advmod more,abundantly
R2973 T3742 T3743 advmod abundantly,detected
R2974 T3743 T3740 acomp detected,was
R2975 T3744 T3743 prep with,detected
R2976 T3745 T3746 amod multiple,foci
R2977 T3746 T3744 pobj foci,with
R2978 T3747 T3746 prep of,foci
R2979 T3748 T3750 amod intense,staining
R2980 T3749 T3750 compound LMP1,staining
R2981 T3750 T3747 pobj staining,of
R2982 T3751 T3740 punct .,was
R2983 T3752 T3753 nsubj This,demonstrates
R2984 T3753 T3753 ROOT demonstrates,demonstrates
R2985 T3754 T3764 mark that,reflects
R2986 T3755 T3757 det the,LMP1
R2987 T3756 T3757 amod increased,LMP1
R2988 T3757 T3764 nsubj LMP1,reflects
R2989 T3758 T3757 acl detected,LMP1
R2990 T3759 T3758 agent by,detected
R2991 T3760 T3759 pcomp immunoblotting,by
R2992 T3761 T3760 prep upon,immunoblotting
R2993 T3762 T3763 compound malignant,progression
R2994 T3763 T3761 pobj progression,upon
R2995 T3764 T3753 ccomp reflects,demonstrates
R2996 T3765 T3766 det an,increase
R2997 T3766 T3764 dobj increase,reflects
R2998 T3767 T3766 prep in,increase
R2999 T3768 T3769 nummod LMP1,expression
R3000 T3769 T3767 pobj expression,in
R3001 T3770 T3769 cc and,expression
R3002 T3771 T3772 det an,accumulation
R3003 T3772 T3766 conj accumulation,increase
R3004 T3773 T3772 prep of,accumulation
R3005 T3774 T3773 pobj cells,of
R3006 T3775 T3774 acl expressing,cells
R3007 T3776 T3777 amod high,levels
R3008 T3777 T3775 dobj levels,expressing
R3009 T3778 T3777 prep of,levels
R3010 T3779 T3778 pobj LMP1,of
R3011 T3780 T3753 punct .,demonstrates
R3012 T3781 T3782 det This,correlation
R3013 T3782 T3792 nsubj correlation,suggests
R3014 T3783 T3782 prep between,correlation
R3015 T3784 T3786 amod high,expression
R3016 T3785 T3786 nummod LMP1,expression
R3017 T3786 T3783 pobj expression,between
R3018 T3787 T3786 cc and,expression
R3019 T3788 T3789 det the,development
R3020 T3789 T3786 conj development,expression
R3021 T3790 T3789 prep of,development
R3022 T3791 T3790 pobj lymphoma,of
R3023 T3792 T3792 ROOT suggests,suggests
R3024 T3793 T3792 dobj that,suggests
R3025 T3794 T3797 compound progression,results
R3026 T3795 T3796 aux to,lymphoma
R3027 T3796 T3797 compound lymphoma,results
R3028 T3797 T3793 nsubj results,that
R3029 T3798 T3797 prep from,results
R3030 T3799 T3800 amod increased,levels
R3031 T3800 T3798 pobj levels,from
R3032 T3801 T3800 prep of,levels
R3033 T3802 T3801 pobj LMP1,of
R3034 T3803 T3792 punct .,suggests
R3702 T4681 T4684 nummod LMP1,Lymphomas
R3703 T4682 T4684 compound Promotes,Lymphomas
R3704 T4683 T4684 compound B-1a,Lymphomas
R3705 T4684 T4732 nsubjpass Lymphomas,analyzed
R3706 T4685 T4687 nsubj That,Escape
R3707 T4686 T4687 aux Can,Escape
R3708 T4687 T4732 advcl Escape,analyzed
R3709 T4688 T4689 compound Allelic,Exclusion
R3710 T4689 T4687 dobj Exclusion,Escape
R3711 T4690 T4691 aux To,determine
R3712 T4691 T4732 advcl determine,analyzed
R3713 T4692 T4695 mark if,affects
R3714 T4693 T4695 nsubj LMP1,affects
R3715 T4694 T4695 nsubj signaling,affects
R3716 T4695 T4691 ccomp affects,determine
R3717 T4696 T4698 compound B,differentiation
R3718 T4697 T4698 compound cell,differentiation
R3719 T4698 T4695 dobj differentiation,affects
R3720 T4699 T4695 cc and,affects
R3721 T4700 T4701 aux to,immunophenotype
R3722 T4701 T4732 advcl immunophenotype,analyzed
R3723 T4702 T4703 det the,lymphomas
R3724 T4703 T4701 dobj lymphomas,immunophenotype
R3725 T4704 T4705 nsubj that,arise
R3726 T4705 T4703 relcl arise,lymphomas
R3727 T4706 T4705 prep from,arise
R3728 T4707 T4708 nummod LMP1,expression
R3729 T4708 T4706 pobj expression,from
R3730 T4709 T4712 punct ",",expression
R3731 T4710 T4712 compound surface,expression
R3732 T4711 T4712 compound Ig,expression
R3733 T4712 T4701 conj expression,immunophenotype
R3734 T4713 T4712 prep of,expression
R3735 T4714 T4715 amod heavy,chains
R3736 T4715 T4713 pobj chains,of
R3737 T4716 T4732 punct (,analyzed
R3738 T4717 T4725 nmod IgM,chains
R3739 T4718 T4717 punct ",",IgM
R3740 T4719 T4717 conj IgG,IgM
R3741 T4720 T4719 punct ",",IgG
R3742 T4721 T4719 conj IgD,IgG
R3743 T4722 T4721 punct ),IgD
R3744 T4723 T4719 cc and,IgG
R3745 T4724 T4725 amod light,chains
R3746 T4725 T4732 nsubjpass chains,analyzed
R3747 T4726 T4727 punct (,κ
R3748 T4727 T4732 nsubjpass κ,analyzed
R3749 T4728 T4729 punct ",",λ
R3750 T4729 T4727 appos λ,κ
R3751 T4730 T4727 punct ),κ
R3752 T4731 T4732 auxpass were,analyzed
R3753 T4732 T4732 ROOT analyzed,analyzed
R3754 T4733 T4732 agent by,analyzed
R3755 T4734 T4735 compound flow,cytometry
R3756 T4735 T4733 pobj cytometry,by
R3757 T4736 T4732 punct .,analyzed
R3758 T4737 T4738 amod Similar,numbers
R3759 T4738 T4761 nsubjpass numbers,detected
R3760 T4739 T4738 prep of,numbers
R3761 T4740 T4739 pobj naïve,of
R3762 T4741 T4747 punct (,−
R3763 T4742 T4747 compound IgM,−
R3764 T4743 T4747 compound +,−
R3765 T4744 T4745 compound IgD,+
R3766 T4745 T4747 compound +,−
R3767 T4746 T4747 compound IgG,−
R3768 T4747 T4738 appos −,numbers
R3769 T4748 T4738 punct ),numbers
R3770 T4749 T4751 amod splenic,cells
R3771 T4750 T4751 compound B,cells
R3772 T4751 T4761 nsubjpass cells,detected
R3773 T4752 T4751 prep with,cells
R3774 T4753 T4755 det a,bias
R3775 T4754 T4755 amod strong,bias
R3776 T4755 T4752 pobj bias,with
R3777 T4756 T4755 prep towards,bias
R3778 T4757 T4759 amod κ,chain
R3779 T4758 T4759 amod light,chain
R3780 T4759 T4756 pobj chain,towards
R3781 T4760 T4761 auxpass were,detected
R3782 T4761 T4761 ROOT detected,detected
R3783 T4762 T4761 prep from,detected
R3784 T4763 T4767 amod wild-type,mice
R3785 T4764 T4763 cc or,wild-type
R3786 T4765 T4763 conj LMP1,wild-type
R3787 T4766 T4767 amod transgenic,mice
R3788 T4767 T4762 pobj mice,from
R3789 T4768 T4761 punct ",",detected
R3790 T4769 T4761 advcl indicating,detected
R3791 T4770 T4775 mark that,affect
R3792 T4771 T4772 nummod LMP1,signaling
R3793 T4772 T4775 nsubj signaling,affect
R3794 T4773 T4775 aux does,affect
R3795 T4774 T4775 neg not,affect
R3796 T4775 T4769 ccomp affect,indicating
R3797 T4776 T4778 compound B,maturation
R3798 T4777 T4778 compound cell,maturation
R3799 T4778 T4775 dobj maturation,affect
R3800 T4779 T4781 punct (,data
R3801 T4780 T4781 amod unpublished,data
R3802 T4781 T4778 appos data,maturation
R3803 T4782 T4775 punct ),affect
R3804 T4783 T4761 punct .,detected
R3805 T4784 T4786 amod Flow,analysis
R3806 T4785 T4786 amod cytometry,analysis
R3807 T4786 T4795 nsubj analysis,revealed
R3808 T4787 T4786 prep of,analysis
R3809 T4788 T4794 det the,lymphomas
R3810 T4789 T4794 nmod SCID-passaged,lymphomas
R3811 T4790 T4789 conj wild-type,SCID-passaged
R3812 T4791 T4790 cc and,wild-type
R3813 T4792 T4790 conj LMP1,wild-type
R3814 T4793 T4794 amod transgenic,lymphomas
R3815 T4794 T4787 pobj lymphomas,of
R3816 T4795 T4795 ROOT revealed,revealed
R3817 T4796 T4798 det an,phenotype
R3818 T4797 T4798 compound IgMhighIgDlow,phenotype
R3819 T4798 T4795 dobj phenotype,revealed
R3820 T4799 T4801 punct (,2A
R3821 T4800 T4801 compound Figure,2A
R3822 T4801 T4798 appos 2A,phenotype
R3823 T4802 T4801 punct ),2A
R3824 T4803 T4798 punct ",",phenotype
R3825 T4804 T4798 amod indicative,phenotype
R3826 T4805 T4804 prep of,indicative
R3827 T4806 T4807 amod marginal,zone
R3828 T4807 T4805 pobj zone,of
R3829 T4808 T4807 punct ",",zone
R3830 T4809 T4807 conj B-1,zone
R3831 T4810 T4809 punct ",",B-1
R3832 T4811 T4809 cc or,B-1
R3833 T4812 T4814 compound memory,cells
R3834 T4813 T4814 compound B,cells
R3835 T4814 T4809 conj cells,B-1
R3836 T4815 T4795 punct .,revealed
R3837 T4816 T4817 amod B-1,cells
R3838 T4817 T4820 nsubjpass cells,separated
R3839 T4818 T4820 auxpass are,separated
R3840 T4819 T4820 advmod further,separated
R3841 T4820 T4820 ROOT separated,separated
R3842 T4821 T4820 prep into,separated
R3843 T4822 T4823 nummod CD5,+
R3844 T4823 T4821 pobj +,into
R3845 T4824 T4823 punct (,+
R3846 T4825 T4823 appos B-1a,+
R3847 T4826 T4823 punct ),+
R3848 T4827 T4820 cc and,separated
R3849 T4828 T4829 nummod CD5,−
R3850 T4829 T4833 npadvmod −,subsets
R3851 T4830 T4831 punct (,B-1b
R3852 T4831 T4829 appos B-1b,−
R3853 T4832 T4831 punct ),B-1b
R3854 T4833 T4820 conj subsets,separated
R3855 T4834 T4820 punct .,separated
R3856 T4835 T4836 aux To,differentiate
R3857 T4836 T4846 advcl differentiate,analyzed
R3858 T4837 T4836 prep between,differentiate
R3859 T4838 T4840 det these,types
R3860 T4839 T4840 compound cell,types
R3861 T4840 T4837 pobj types,between
R3862 T4841 T4846 punct ",",analyzed
R3863 T4842 T4843 compound lymphoma,cells
R3864 T4843 T4846 nsubjpass cells,analyzed
R3865 T4844 T4846 auxpass were,analyzed
R3866 T4845 T4846 advmod further,analyzed
R3867 T4846 T4846 ROOT analyzed,analyzed
R3868 T4847 T4846 prep for,analyzed
R3869 T4848 T4850 det the,marker
R3870 T4849 T4850 compound B-1a,marker
R3871 T4850 T4847 pobj marker,for
R3872 T4851 T4850 appos CD5,marker
R3873 T4852 T4846 punct .,analyzed
R3874 T4853 T4863 nsubj All,displayed
R3875 T4854 T4855 punct (,5/5
R3876 T4855 T4853 appos 5/5,All
R3877 T4856 T4855 punct ),5/5
R3878 T4857 T4855 prep of,5/5
R3879 T4858 T4862 det the,lymphomas
R3880 T4859 T4862 amod tested,lymphomas
R3881 T4860 T4862 nmod LMP1,lymphomas
R3882 T4861 T4862 amod transgenic,lymphomas
R3883 T4862 T4857 pobj lymphomas,of
R3884 T4863 T4863 ROOT displayed,displayed
R3885 T4864 T4867 det an,phenotype
R3886 T4865 T4867 amod IgMhighIgDlowCD5,phenotype
R3887 T4866 T4867 compound +,phenotype
R3888 T4867 T4863 dobj phenotype,displayed
R3889 T4868 T4870 punct (,2A
R3890 T4869 T4870 compound Figure,2A
R3891 T4870 T4867 appos 2A,phenotype
R3892 T4871 T4867 punct ),phenotype
R3893 T4872 T4867 punct ",",phenotype
R3894 T4873 T4875 det an,pattern
R3895 T4874 T4875 compound expression,pattern
R3896 T4875 T4867 appos pattern,phenotype
R3897 T4876 T4877 nsubj that,distinguishes
R3898 T4877 T4875 relcl distinguishes,pattern
R3899 T4878 T4879 amod B-1a,cells
R3900 T4879 T4877 dobj cells,distinguishes
R3901 T4880 T4863 punct .,displayed
R3902 T4881 T4888 advmod Interestingly,developed
R3903 T4882 T4888 punct ",",developed
R3904 T4883 T4886 det a,lymphoma
R3905 T4884 T4886 amod spontaneous,lymphoma
R3906 T4885 T4886 amod wild-type,lymphoma
R3907 T4886 T4888 nsubj lymphoma,developed
R3908 T4887 T4888 advmod also,developed
R3909 T4888 T4888 ROOT developed,developed
R3910 T4889 T4888 prep in,developed
R3911 T4890 T4891 amod B-1a,cells
R3912 T4891 T4889 pobj cells,in
R3913 T4892 T4894 punct (,2A
R3914 T4893 T4894 compound Figure,2A
R3915 T4894 T4891 appos 2A,cells
R3916 T4895 T4888 punct ),developed
R3917 T4896 T4888 punct .,developed
R3918 T4897 T4898 det These,cells
R3919 T4898 T4899 nsubj cells,are
R3920 T4899 T4899 ROOT are,are
R3921 T4900 T4902 det an,population
R3922 T4901 T4902 amod interesting,population
R3923 T4902 T4899 attr population,are
R3924 T4903 T4904 nsubj that,is
R3925 T4904 T4902 relcl is,population
R3926 T4905 T4906 npadvmod self,replenishing
R3927 T4906 T4904 acomp replenishing,is
R3928 T4907 T4906 prep with,replenishing
R3929 T4908 T4910 det an,likelihood
R3930 T4909 T4910 amod increased,likelihood
R3931 T4910 T4907 pobj likelihood,with
R3932 T4911 T4912 aux to,become
R3933 T4912 T4910 acl become,likelihood
R3934 T4913 T4912 acomp malignant,become
R3935 T4914 T4913 prep in,malignant
R3936 T4915 T4916 amod aged,mice
R3937 T4916 T4914 pobj mice,in
R3938 T4917 T4919 nmod [,]
R3939 T4918 T4919 nummod 30,]
R3940 T4919 T4916 appos ],mice
R3941 T4920 T4899 punct .,are
R3942 T4921 T4931 nsubj Analysis,showed
R3943 T4922 T4921 prep of,Analysis
R3944 T4923 T4925 nummod LMP1,mice
R3945 T4924 T4925 amod transgenic,mice
R3946 T4925 T4922 pobj mice,of
R3947 T4926 T4921 prep before,Analysis
R3948 T4927 T4928 det the,development
R3949 T4928 T4931 nsubj development,showed
R3950 T4929 T4928 prep of,development
R3951 T4930 T4929 pobj lymphoma,of
R3952 T4931 T4931 ROOT showed,showed
R3953 T4932 T4933 amod similar,numbers
R3954 T4933 T4931 dobj numbers,showed
R3955 T4934 T4933 prep of,numbers
R3956 T4935 T4936 amod splenic,B-1a
R3957 T4936 T4934 pobj B-1a,of
R3958 T4937 T4936 punct (,B-1a
R3959 T4938 T4941 nummod CD19,+
R3960 T4939 T4941 nmod +,+
R3961 T4940 T4939 dep CD5,+
R3962 T4941 T4936 appos +,B-1a
R3963 T4942 T4936 punct ),B-1a
R3964 T4943 T4936 cc and,B-1a
R3965 T4944 T4955 dep B-1b,indicating
R3966 T4945 T4944 cc or,B-1b
R3967 T4946 T4944 conj B-2,B-1b
R3968 T4947 T4944 conj populations,B-1b
R3969 T4948 T4947 punct (,populations
R3970 T4949 T4950 nummod CD19,+
R3971 T4950 T4947 appos +,populations
R3972 T4951 T4952 nummod CD5,−
R3973 T4952 T4950 appos −,+
R3974 T4953 T4950 punct ),+
R3975 T4954 T4947 punct ",",populations
R3976 T4955 T4931 advcl indicating,showed
R3977 T4956 T4960 mark that,affect
R3978 T4957 T4960 nsubj LMP1,affect
R3979 T4958 T4960 aux does,affect
R3980 T4959 T4960 neg not,affect
R3981 T4960 T4955 ccomp affect,indicating
R3982 T4961 T4963 compound B,differentiation
R3983 T4962 T4963 compound cell,differentiation
R3984 T4963 T4960 dobj differentiation,affect
R3985 T4964 T4966 punct (,2B
R3986 T4965 T4966 compound Figure,2B
R3987 T4966 T4963 appos 2B,differentiation
R3988 T4967 T4955 punct ),indicating
R3989 T4968 T4931 punct .,showed
R3990 T4969 T4976 amod Due,cells
R3991 T4970 T4969 pcomp to,Due
R3992 T4971 T4972 amod allelic,exclusion
R3993 T4972 T4976 compound exclusion,cells
R3994 T4973 T4974 punct ",",mature
R3995 T4974 T4976 amod mature,cells
R3996 T4975 T4976 compound B,cells
R3997 T4976 T4985 nsubj cells,express
R3998 T4977 T4980 nsubjpass that,exposed
R3999 T4978 T4980 aux have,exposed
R4000 T4979 T4980 auxpass been,exposed
R4001 T4980 T4976 relcl exposed,cells
R4002 T4981 T4980 prep to,exposed
R4003 T4982 T4981 pobj antigen,to
R4004 T4983 T4985 aux will,express
R4005 T4984 T4985 advmod typically,express
R4006 T4985 T4985 ROOT express,express
R4007 T4986 T4987 advmod only,one
R4008 T4987 T4989 nummod one,chain
R4009 T4988 T4989 amod heavy,chain
R4010 T4989 T4985 dobj chain,express
R4011 T4990 T4985 conj isotype,express
R4012 T4991 T4992 punct (,IgG
R4013 T4992 T4990 dobj IgG,isotype
R4014 T4993 T4992 punct ",",IgG
R4015 T4994 T4992 conj IgE,IgG
R4016 T4995 T4994 punct ",",IgE
R4017 T4996 T4994 cc or,IgE
R4018 T4997 T4994 conj IgA,IgE
R4019 T4998 T4997 punct ),IgA
R4020 T4999 T4990 cc and,isotype
R4021 T5000 T5002 preconj either,κ
R4022 T5001 T5002 det a,κ
R4023 T5002 T5006 nmod κ,chain
R4024 T5003 T5002 cc or,κ
R4025 T5004 T5002 conj λ,κ
R4026 T5005 T5006 amod light,chain
R4027 T5006 T4990 conj chain,isotype
R4028 T5007 T4985 punct .,express
R4029 T5008 T5014 advmod Interestingly,analyzed
R4030 T5009 T5014 punct ",",analyzed
R4031 T5010 T5013 nummod 2/5,lymphomas
R4032 T5011 T5013 nummod LMP1,lymphomas
R4033 T5012 T5013 amod transgenic,lymphomas
R4034 T5013 T5014 nsubj lymphomas,analyzed
R4035 T5014 T5014 ROOT analyzed,analyzed
R4036 T5015 T5016 punct (,lymphomas
R4037 T5016 T5014 dobj lymphomas,analyzed
R4038 T5017 T5016 nummod 2,lymphomas
R4039 T5018 T5017 cc and,2
R4040 T5019 T5017 conj 4,2
R4041 T5020 T5017 punct ),2
R4042 T5021 T5014 conj were,analyzed
R4043 T5022 T5023 advmod doubly,positive
R4044 T5023 T5021 acomp positive,were
R4045 T5024 T5023 prep for,positive
R4046 T5025 T5026 amod low,levels
R4047 T5026 T5024 pobj levels,for
R4048 T5027 T5026 prep of,levels
R4049 T5028 T5029 det both,κ
R4050 T5029 T5027 pobj κ,of
R4051 T5030 T5029 cc and,κ
R4052 T5031 T5033 compound λ,chains
R4053 T5032 T5033 compound light,chains
R4054 T5033 T5029 conj chains,κ
R4055 T5034 T5036 punct (,2A
R4056 T5035 T5036 compound Figure,2A
R4057 T5036 T5033 appos 2A,chains
R4058 T5037 T5036 punct ),2A
R4059 T5038 T5014 punct .,analyzed
R4060 T5039 T5040 amod Previous,characterization
R4061 T5040 T5046 nsubj characterization,revealed
R4062 T5041 T5040 prep of,characterization
R4063 T5042 T5044 det the,lymphomas
R4064 T5043 T5044 compound LMP1,lymphomas
R4065 T5044 T5041 pobj lymphomas,of
R4066 T5045 T5046 aux had,revealed
R4067 T5046 T5080 ccomp revealed,confirmed
R4068 T5047 T5051 mark that,clonal
R4069 T5048 T5049 det the,lymphomas
R4070 T5049 T5051 nsubjpass lymphomas,clonal
R4071 T5050 T5051 auxpass were,clonal
R4072 T5051 T5046 ccomp clonal,revealed
R4073 T5052 T5053 mark as,determined
R4074 T5053 T5051 advcl determined,clonal
R4075 T5054 T5053 agent by,determined
R4076 T5055 T5057 nmod Ig,chain
R4077 T5056 T5057 amod heavy,chain
R4078 T5057 T5058 compound chain,rearrangement
R4079 T5058 T5054 pobj rearrangement,by
R4080 T5059 T5061 nmod [,]
R4081 T5060 T5061 nummod 26,]
R4082 T5061 T5080 nsubj ],confirmed
R4083 T5062 T5061 punct ",",]
R4084 T5063 T5061 cc and,]
R4085 T5064 T5061 conj analysis,]
R4086 T5065 T5064 prep of,analysis
R4087 T5066 T5068 compound κ,rearrangement
R4088 T5067 T5068 compound chain,rearrangement
R4089 T5068 T5065 pobj rearrangement,of
R4090 T5069 T5070 punct (,Figure
R4091 T5070 T5068 appos Figure,rearrangement
R4092 T5071 T5070 nummod S1,Figure
R4093 T5072 T5070 punct ),Figure
R4094 T5073 T5070 prep of,Figure
R4095 T5074 T5075 det the,samples
R4096 T5075 T5073 pobj samples,of
R4097 T5076 T5075 acl analyzed,samples
R4098 T5077 T5076 prep in,analyzed
R4099 T5078 T5079 det this,study
R4100 T5079 T5077 pobj study,in
R4101 T5080 T5080 ROOT confirmed,confirmed
R4102 T5081 T5080 dobj clonality,confirmed
R4103 T5082 T5080 punct .,confirmed
R4104 T5083 T5085 aux To,assess
R4105 T5084 T5085 advmod further,assess
R4106 T5085 T5094 advcl assess,tested
R4107 T5086 T5088 amod light,expression
R4108 T5087 T5088 compound chain,expression
R4109 T5088 T5085 dobj expression,assess
R4110 T5089 T5094 punct ",",tested
R4111 T5090 T5092 det the,samples
R4112 T5091 T5092 amod passaged,samples
R4113 T5092 T5094 nsubjpass samples,tested
R4114 T5093 T5094 auxpass were,tested
R4115 T5094 T5094 ROOT tested,tested
R4116 T5095 T5094 agent by,tested
R4117 T5096 T5095 pcomp immunoblotting,by
R4118 T5097 T5096 prep for,immunoblotting
R4119 T5098 T5097 pobj κ,for
R4120 T5099 T5098 cc and,κ
R4121 T5100 T5102 compound λ,chains
R4122 T5101 T5102 compound light,chains
R4123 T5102 T5098 conj chains,κ
R4124 T5103 T5104 punct (,Figure
R4125 T5104 T5094 npadvmod Figure,tested
R4126 T5105 T5104 nummod 2C,Figure
R4127 T5106 T5104 punct ),Figure
R4128 T5107 T5094 punct .,tested
R4129 T5108 T5120 advmod Interestingly,detected
R4130 T5109 T5120 punct ",",detected
R4131 T5110 T5111 advmod very,low
R4132 T5111 T5112 amod low,levels
R4133 T5112 T5120 nsubjpass levels,detected
R4134 T5113 T5112 prep of,levels
R4135 T5114 T5113 pobj expression,of
R4136 T5115 T5114 prep of,expression
R4137 T5116 T5118 det both,chains
R4138 T5117 T5118 amod light,chains
R4139 T5118 T5115 pobj chains,of
R4140 T5119 T5120 auxpass were,detected
R4141 T5120 T5120 ROOT detected,detected
R4142 T5121 T5120 agent by,detected
R4143 T5122 T5123 compound flow,cytometry
R4144 T5123 T5121 pobj cytometry,by
R4145 T5124 T5120 punct .,detected
R4146 T5125 T5127 det The,levels
R4147 T5126 T5127 amod low,levels
R4148 T5127 T5131 nsubj levels,reflect
R4149 T5128 T5127 prep of,levels
R4150 T5129 T5128 pobj expression,of
R4151 T5130 T5131 aux may,reflect
R4152 T5131 T5131 ROOT reflect,reflect
R4153 T5132 T5133 det a,limitation
R4154 T5133 T5131 dobj limitation,reflect
R4155 T5134 T5133 prep of,limitation
R4156 T5135 T5137 det the,number
R4157 T5136 T5137 amod total,number
R4158 T5137 T5134 pobj number,of
R4159 T5138 T5137 prep of,number
R4160 T5139 T5140 amod light,chains
R4161 T5140 T5138 pobj chains,of
R4162 T5141 T5144 nsubjpass that,expressed
R4163 T5142 T5144 aux can,expressed
R4164 T5143 T5144 auxpass be,expressed
R4165 T5144 T5140 relcl expressed,chains
R4166 T5145 T5144 prep on,expressed
R4167 T5146 T5147 det the,surface
R4168 T5147 T5145 pobj surface,on
R4169 T5148 T5147 prep of,surface
R4170 T5149 T5151 det a,cell
R4171 T5150 T5151 compound B,cell
R4172 T5151 T5148 pobj cell,of
R4173 T5152 T5131 punct .,reflect
R4174 T5153 T5167 prep In,were
R4175 T5154 T5153 pobj agreement,In
R4176 T5155 T5154 prep with,agreement
R4177 T5156 T5159 det the,analysis
R4178 T5157 T5159 compound flow,analysis
R4179 T5158 T5159 compound cytometry,analysis
R4180 T5159 T5155 pobj analysis,with
R4181 T5160 T5159 punct ",",analysis
R4182 T5161 T5163 nmod LMP1,lymphomas
R4183 T5162 T5163 amod transgenic,lymphomas
R4184 T5163 T5167 nsubj lymphomas,were
R4185 T5164 T5163 nummod 2,lymphomas
R4186 T5165 T5164 cc and,2
R4187 T5166 T5164 conj 4,2
R4188 T5167 T5167 ROOT were,were
R4189 T5168 T5167 advmod also,were
R4190 T5169 T5167 acomp positive,were
R4191 T5170 T5169 prep for,positive
R4192 T5171 T5175 nmod κ,chains
R4193 T5172 T5171 cc and,κ
R4194 T5173 T5175 compound λ,chains
R4195 T5174 T5175 compound light,chains
R4196 T5175 T5170 pobj chains,for
R4197 T5176 T5167 prep by,were
R4198 T5177 T5178 compound immunoblot,analysis
R4199 T5178 T5176 pobj analysis,by
R4200 T5179 T5180 punct (,Figure
R4201 T5180 T5178 appos Figure,analysis
R4202 T5181 T5180 npadvmod 2C,Figure
R4203 T5182 T5180 punct ),Figure
R4204 T5183 T5167 punct ",",were
R4205 T5184 T5167 advcl confirming,were
R4206 T5185 T5188 mark that,express
R4207 T5186 T5187 det these,lymphomas
R4208 T5187 T5188 nsubj lymphomas,express
R4209 T5188 T5184 ccomp express,confirming
R4210 T5189 T5191 det both,chains
R4211 T5190 T5191 amod light,chains
R4212 T5191 T5188 dobj chains,express
R4213 T5192 T5167 punct .,were
R4214 T5193 T5195 det A,study
R4215 T5194 T5195 amod previous,study
R4216 T5195 T5209 nsubj study,determined
R4217 T5196 T5195 prep of,study
R4218 T5197 T5196 pobj mice,of
R4219 T5198 T5199 nsubj that,developed
R4220 T5199 T5197 relcl developed,mice
R4221 T5200 T5199 dobj leukemia,developed
R4222 T5201 T5200 amod due,leukemia
R4223 T5202 T5201 pcomp to,due
R4224 T5203 T5204 det an,expansion
R4225 T5204 T5209 nsubj expansion,determined
R4226 T5205 T5204 prep of,expansion
R4227 T5206 T5208 amod self-reactive,cells
R4228 T5207 T5208 amod B-1a,cells
R4229 T5208 T5205 pobj cells,of
R4230 T5209 T5209 ROOT determined,determined
R4231 T5210 T5214 mark that,were
R4232 T5211 T5213 det the,leukemias
R4233 T5212 T5213 compound B-1a,leukemias
R4234 T5213 T5214 nsubj leukemias,were
R4235 T5214 T5209 ccomp were,determined
R4236 T5215 T5214 advmod also,were
R4237 T5216 T5217 advmod doubly,positive
R4238 T5217 T5214 acomp positive,were
R4239 T5218 T5217 prep for,positive
R4240 T5219 T5223 nmod κ,chains
R4241 T5220 T5219 cc and,κ
R4242 T5221 T5223 compound λ,chains
R4243 T5222 T5223 compound light,chains
R4244 T5223 T5218 pobj chains,for
R4245 T5224 T5226 nmod [,]
R4246 T5225 T5226 nummod 31,]
R4247 T5226 T5223 appos ],chains
R4248 T5227 T5209 punct .,determined
R4249 T5228 T5229 det These,findings
R4250 T5229 T5230 nsubj findings,indicate
R4251 T5230 T5230 ROOT indicate,indicate
R4252 T5231 T5238 mark that,promotes
R4253 T5232 T5238 nsubj expression,promotes
R4254 T5233 T5232 prep of,expression
R4255 T5234 T5233 pobj LMP1,of
R4256 T5235 T5234 prep in,LMP1
R4257 T5236 T5237 amod B-1a,cells
R4258 T5237 T5235 pobj cells,in
R4259 T5238 T5230 ccomp promotes,indicate
R4260 T5239 T5240 det the,development
R4261 T5240 T5238 dobj development,promotes
R4262 T5241 T5240 prep of,development
R4263 T5242 T5241 pobj malignancy,of
R4264 T5243 T5238 cc and,promotes
R4265 T5244 T5245 aux can,result
R4266 T5245 T5238 conj result,promotes
R4267 T5246 T5245 prep in,result
R4268 T5247 T5249 det the,escape
R4269 T5248 T5249 amod aberrant,escape
R4270 T5249 T5246 pobj escape,in
R4271 T5250 T5249 prep from,escape
R4272 T5251 T5252 amod allelic,exclusion
R4273 T5252 T5250 pobj exclusion,from
R4274 T5253 T5230 punct .,indicate
R5219 T6746 T6747 auxpass was,assessed
R5220 T6747 T6733 ccomp assessed,investigate
R5221 T6748 T6747 agent by,assessed
R5222 T6749 T6752 det an,assay
R5223 T6750 T6752 amod Rnase,assay
R5224 T6751 T6752 compound protection,assay
R5225 T6752 T6748 pobj assay,by
R5226 T6753 T6752 punct (,assay
R5227 T6754 T6752 appos RPA,assay
R5228 T6755 T6752 punct ),assay
R5229 T6756 T6727 punct .,Require
R5230 T6757 T6758 nummod IL4,transcription
R5231 T6758 T6759 nsubj transcription,was
R5232 T6759 T6759 ROOT was,was
R5233 T6760 T6759 acomp detectable,was
R5234 T6761 T6760 prep with,detectable
R5235 T6762 T6763 compound control,RNA
R5236 T6763 T6761 pobj RNA,with
R5237 T6764 T6763 cc and,RNA
R5238 T6765 T6759 advmod faintly,was
R5239 T6766 T6759 prep in,was
R5240 T6767 T6771 det the,line
R5241 T6768 T6770 compound mouse,cell
R5242 T6769 T6770 compound lymphoma,cell
R5243 T6770 T6771 compound cell,line
R5244 T6771 T6766 pobj line,in
R5245 T6772 T6771 appos K46μ,line
R5246 T6773 T6775 punct (,4A
R5247 T6774 T6775 compound Figure,4A
R5248 T6775 T6772 appos 4A,K46μ
R5249 T6776 T6772 punct ),K46μ
R5250 T6777 T6759 punct .,was
R5251 T6778 T6782 advmod However,was
R5252 T6779 T6782 punct ",",was
R5253 T6780 T6781 compound IL4,transcription
R5254 T6781 T6782 nsubj transcription,was
R5255 T6782 T6782 ROOT was,was
R5256 T6783 T6782 neg not,was
R5257 T6784 T6782 acomp detectable,was
R5258 T6785 T6784 prep in,detectable
R5259 T6786 T6789 compound CD19,B
R5260 T6787 T6789 compound +,B
R5261 T6788 T6789 compound MACS-purified,B
R5262 T6789 T6790 compound B,cells
R5263 T6790 T6785 pobj cells,in
R5264 T6791 T6790 prep from,cells
R5265 T6792 T6793 amod wild-type,lymphocytes
R5266 T6793 T6791 pobj lymphocytes,from
R5267 T6794 T6793 punct (,lymphocytes
R5268 T6795 T6796 amod unpublished,data
R5269 T6796 T6793 appos data,lymphocytes
R5270 T6797 T6793 punct ),lymphocytes
R5271 T6798 T6782 punct ",",was
R5272 T6799 T6801 nmod LMP1,lymphocytes
R5273 T6800 T6801 amod transgenic,lymphocytes
R5274 T6801 T6782 attr lymphocytes,was
R5275 T6802 T6801 punct ",",lymphocytes
R5276 T6803 T6801 cc or,lymphocytes
R5277 T6804 T6805 compound lymphoma,cells
R5278 T6805 T6801 conj cells,lymphocytes
R5279 T6806 T6782 punct ",",was
R5280 T6807 T6815 mark although,protected
R5281 T6808 T6812 det the,controls
R5282 T6809 T6812 nmod GAPDH,controls
R5283 T6810 T6809 cc and,GAPDH
R5284 T6811 T6809 conj L32,GAPDH
R5285 T6812 T6815 nsubjpass controls,protected
R5286 T6813 T6815 auxpass were,protected
R5287 T6814 T6815 advmod effectively,protected
R5288 T6815 T6782 advcl protected,was
R5289 T6816 T6818 punct (,4A
R5290 T6817 T6818 compound Figure,4A
R5291 T6818 T6815 oprd 4A,protected
R5292 T6819 T6818 punct ),4A
R5293 T6820 T6782 punct .,was
R5294 T6821 T6822 compound Activated,Stat6
R5295 T6822 T6836 nsubjpass Stat6,detected
R5296 T6823 T6822 punct (,Stat6
R5297 T6824 T6822 appos pStat6,Stat6
R5298 T6825 T6822 punct ),Stat6
R5299 T6826 T6822 punct ",",Stat6
R5300 T6827 T6828 det a,target
R5301 T6828 T6822 appos target,Stat6
R5302 T6829 T6828 prep of,target
R5303 T6830 T6833 det the,pathway
R5304 T6831 T6833 compound IL4,pathway
R5305 T6832 T6833 compound receptor,pathway
R5306 T6833 T6829 pobj pathway,of
R5307 T6834 T6836 punct ",",detected
R5308 T6835 T6836 auxpass was,detected
R5309 T6836 T6836 ROOT detected,detected
R5310 T6837 T6836 prep in,detected
R5311 T6838 T6843 det the,lymphocytes
R5312 T6839 T6843 nmod wild-type,lymphocytes
R5313 T6840 T6839 cc and,wild-type
R5314 T6841 T6839 conj LMP1,wild-type
R5315 T6842 T6843 amod transgenic,lymphocytes
R5316 T6843 T6837 pobj lymphocytes,in
R5317 T6844 T6846 punct (,4B
R5318 T6845 T6846 compound Figure,4B
R5319 T6846 T6843 appos 4B,lymphocytes
R5320 T6847 T6843 punct ),lymphocytes
R5321 T6848 T6836 punct .,detected
R5322 T6849 T6855 prep In,detected
R5323 T6850 T6849 pobj contrast,In
R5324 T6851 T6855 punct ",",detected
R5325 T6852 T6855 nsubjpass pStat6,detected
R5326 T6853 T6855 auxpass was,detected
R5327 T6854 T6855 advmod barely,detected
R5328 T6855 T6855 ROOT detected,detected
R5329 T6856 T6855 prep in,detected
R5330 T6857 T6864 preconj either,cells
R5331 T6858 T6864 det the,cells
R5332 T6859 T6864 amod wild-type,cells
R5333 T6860 T6859 cc or,wild-type
R5334 T6861 T6859 conj LMP1,wild-type
R5335 T6862 T6864 amod transgenic,cells
R5336 T6863 T6864 compound lymphoma,cells
R5337 T6864 T6856 pobj cells,in
R5338 T6865 T6855 punct .,detected
R5339 T6866 T6870 advmod However,was
R5340 T6867 T6870 punct ",",was
R5341 T6868 T6869 det the,pathway
R5342 T6869 T6870 nsubj pathway,was
R5343 T6870 T6870 ROOT was,was
R5344 T6871 T6870 neg not,was
R5345 T6872 T6870 acomp disabled,was
R5346 T6873 T6872 punct ",",disabled
R5347 T6874 T6872 prep as,disabled
R5348 T6875 T6874 pobj treatment,as
R5349 T6876 T6875 prep of,treatment
R5350 T6877 T6879 det the,cells
R5351 T6878 T6879 compound lymphoma,cells
R5352 T6879 T6876 pobj cells,of
R5353 T6880 T6875 prep with,treatment
R5354 T6881 T6880 pobj IL4,with
R5355 T6882 T6870 conj induced,was
R5356 T6883 T6884 compound Stat6,phosphorylation
R5357 T6884 T6882 dobj phosphorylation,induced
R5358 T6885 T6887 punct (,4C
R5359 T6886 T6887 compound Figure,4C
R5360 T6887 T6884 appos 4C,phosphorylation
R5361 T6888 T6887 punct ),4C
R5362 T6889 T6870 punct .,was
R5363 T6890 T6896 mark Although,maintained
R5364 T6891 T6892 amod wild-type,lymphocytes
R5365 T6892 T6896 nsubjpass lymphocytes,maintained
R5366 T6893 T6896 aux can,maintained
R5367 T6894 T6896 neg not,maintained
R5368 T6895 T6896 auxpass be,maintained
R5369 T6896 T6915 advcl maintained,detected
R5370 T6897 T6896 prep in,maintained
R5371 T6898 T6897 pobj culture,in
R5372 T6899 T6896 prep with,maintained
R5373 T6900 T6901 nummod IL4,supplementation
R5374 T6901 T6899 pobj supplementation,with
R5375 T6902 T6901 advmod alone,supplementation
R5376 T6903 T6905 punct (,3A
R5377 T6904 T6905 compound Figure,3A
R5378 T6905 T6901 appos 3A,supplementation
R5379 T6906 T6901 punct ),supplementation
R5380 T6907 T6901 punct ",",supplementation
R5381 T6908 T6909 amod slight,enhancement
R5382 T6909 T6901 appos enhancement,supplementation
R5383 T6910 T6909 prep in,enhancement
R5384 T6911 T6912 compound MTS,activity
R5385 T6912 T6910 pobj activity,in
R5386 T6913 T6915 aux could,detected
R5387 T6914 T6915 auxpass be,detected
R5388 T6915 T6915 ROOT detected,detected
R5389 T6916 T6920 mark if,analyzed
R5390 T6917 T6918 det the,cells
R5391 T6918 T6920 nsubjpass cells,analyzed
R5392 T6919 T6920 auxpass were,analyzed
R5393 T6920 T6915 advcl analyzed,detected
R5394 T6921 T6920 prep at,analyzed
R5395 T6922 T6925 det an,point
R5396 T6923 T6925 amod earlier,point
R5397 T6924 T6925 compound time,point
R5398 T6925 T6921 pobj point,at
R5399 T6926 T6920 punct ",",analyzed
R5400 T6927 T6920 prep at,analyzed
R5401 T6928 T6929 nummod 1,d
R5403 T6930 T6931 punct (,Figure
R5404 T6931 T6929 appos Figure,d
R5405 T6932 T6931 nummod 4D,Figure
R5406 T6933 T6931 punct ),Figure
R5407 T6934 T6929 cc versus,d
R5408 T6935 T6936 nummod 3,d
R5409 T6936 T6929 conj d,d
R5410 T6937 T6939 punct (,3A
R5411 T6938 T6939 compound Figure,3A
R5412 T6939 T6936 npadvmod 3A,d
R5413 T6940 T6939 punct ),3A
R5414 T6941 T6941 ROOT post-harvest,post-harvest
R5415 T6942 T6941 punct .,post-harvest
R5416 T6943 T6944 det The,enhancement
R5417 T6944 T6956 nsubjpass enhancement,neutralized
R5418 T6945 T6944 prep of,enhancement
R5419 T6946 T6947 compound MTS,activity
R5420 T6947 T6945 pobj activity,of
R5421 T6948 T6944 acl induced,enhancement
R5422 T6949 T6948 agent by,induced
R5423 T6950 T6949 pobj IL4,by
R5424 T6951 T6948 prep in,induced
R5425 T6952 T6953 amod wild-type,lymphocytes
R5426 T6953 T6951 pobj lymphocytes,in
R5427 T6954 T6956 aux could,neutralized
R5428 T6955 T6956 auxpass be,neutralized
R5429 T6956 T6956 ROOT neutralized,neutralized
R5430 T6957 T6956 agent by,neutralized
R5431 T6958 T6959 det the,addition
R5432 T6959 T6957 pobj addition,by
R5433 T6960 T6959 prep of,addition
R5434 T6961 T6962 nummod IL4,antibody
R5435 T6962 T6960 pobj antibody,of
R5436 T6963 T6964 punct (,Figure
R5437 T6964 T6962 appos Figure,antibody
R5438 T6965 T6964 nummod 4D,Figure
R5439 T6966 T6964 punct ),Figure
R5440 T6967 T6956 punct .,neutralized
R5441 T6968 T6976 advmod However,affect
R5442 T6969 T6976 punct ",",affect
R5443 T6970 T6976 csubj neutralizing,affect
R5444 T6971 T6970 dobj antibodies,neutralizing
R5445 T6972 T6970 prep to,neutralizing
R5446 T6973 T6972 pobj IL4,to
R5447 T6974 T6976 aux did,affect
R5448 T6975 T6976 neg not,affect
R5449 T6976 T6976 ROOT affect,affect
R5450 T6977 T6979 det the,activity
R5451 T6978 T6979 compound MTS,activity
R5452 T6979 T6976 dobj activity,affect
R5453 T6980 T6979 prep of,activity
R5454 T6981 T6984 nummod LMP1,cells
R5455 T6982 T6984 amod transgenic,cells
R5456 T6983 T6984 compound lymphoma,cells
R5457 T6984 T6980 pobj cells,of
R5458 T6985 T6986 punct (,Figure
R5459 T6986 T6984 appos Figure,cells
R5460 T6987 T6986 nummod 4E,Figure
R5461 T6988 T6986 punct ),Figure
R5462 T6989 T6976 punct .,affect
R5463 T6990 T7000 prep In,grew
R5464 T6991 T6990 pobj summary,In
R5465 T6992 T7000 punct ",",grew
R5466 T6993 T6999 det the,cells
R5467 T6994 T6999 amod wild-type,cells
R5468 T6995 T6994 cc and,wild-type
R5469 T6996 T6994 conj LMP1,wild-type
R5470 T6997 T6999 amod transgenic,cells
R5471 T6998 T6999 compound lymphoma,cells
R5472 T6999 T7000 nsubj cells,grew
R5473 T7000 T7000 ROOT grew,grew
R5474 T7001 T7000 advmod independently,grew
R5475 T7002 T7001 prep of,independently
R5476 T7003 T7004 nummod IL4,treatment
R5477 T7004 T7002 pobj treatment,of
R5478 T7005 T7000 cc and,grew
R5479 T7006 T7008 aux did,require
R5480 T7007 T7008 neg not,require
R5482 T7009 T7010 amod Stat6,signaling
R5483 T7010 T7008 dobj signaling,require
R5484 T7011 T7000 punct .,grew
R6358 T8264 T8266 nummod LMP1,IL10
R6359 T8265 T8266 compound Upregulates,IL10
R6360 T8266 T8272 nsubj IL10,identify
R6361 T8267 T8266 cc and,IL10
R6362 T8268 T8269 nsubj Constitutively,Activates
R6363 T8269 T8266 conj Activates,IL10
R6364 T8270 T8269 dobj Stat3,Activates
R6365 T8271 T8272 aux To,identify
R6366 T8272 T8272 ROOT identify,identify
R6367 T8273 T8272 dobj cytokines,identify
R6368 T8274 T8276 nsubj that,contribute
R6369 T8275 T8276 aux may,contribute
R6370 T8276 T8273 relcl contribute,cytokines
R6371 T8277 T8276 prep to,contribute
R6372 T8278 T8280 det the,survival
R6373 T8279 T8280 amod increased,survival
R6374 T8280 T8277 pobj survival,to
R6375 T8281 T8280 cc and,survival
R6376 T8282 T8280 conj growth,survival
R6377 T8283 T8282 prep of,growth
R6378 T8284 T8283 pobj lymphomas,of
R6379 T8285 T8295 punct ",",screened
R6380 T8286 T8288 det the,levels
R6381 T8287 T8288 compound expression,levels
R6382 T8288 T8295 nsubjpass levels,screened
R6383 T8289 T8288 prep of,levels
R6384 T8290 T8291 det a,panel
R6385 T8291 T8289 pobj panel,of
R6386 T8292 T8291 prep of,panel
R6387 T8293 T8292 pobj cytokines,of
R6388 T8294 T8295 auxpass were,screened
R6389 T8295 T8272 conj screened,identify
R6390 T8296 T8295 prep on,screened
R6391 T8297 T8301 compound CD19,cells
R6392 T8298 T8300 compound +,B
R6393 T8299 T8300 compound MACS-purified,B
R6394 T8300 T8301 compound B,cells
R6395 T8301 T8296 pobj cells,on
R6396 T8302 T8295 punct ",",screened
R6397 T8303 T8295 advcl using,screened
R6398 T8304 T8306 det an,probe
R6399 T8305 T8306 compound RPA,probe
R6400 T8306 T8307 compound probe,set
R6401 T8307 T8303 dobj set,using
R6402 T8308 T8307 prep for,set
R6403 T8309 T8308 pobj IL4,for
R6404 T8310 T8309 punct ",",IL4
R6405 T8311 T8309 conj IL5,IL4
R6406 T8312 T8311 punct ",",IL5
R6407 T8313 T8311 conj IL10,IL5
R6408 T8314 T8313 punct ",",IL10
R6409 T8315 T8313 conj IL13,IL10
R6410 T8316 T8315 punct ",",IL13
R6411 T8317 T8315 conj IL15,IL13
R6412 T8318 T8317 punct ",",IL15
R6413 T8319 T8317 conj IL9,IL15
R6414 T8320 T8319 punct ",",IL9
R6415 T8321 T8319 conj IL2,IL9
R6416 T8322 T8321 punct ",",IL2
R6417 T8323 T8321 conj IL6,IL2
R6418 T8324 T8323 punct ",",IL6
R6419 T8325 T8323 cc and,IL6
R6420 T8326 T8323 conj IFNγ,IL6
R6421 T8327 T8295 punct .,screened
R6422 T8328 T8329 compound Expression,levels
R6423 T8329 T8331 nsubjpass levels,quantified
R6424 T8330 T8331 auxpass were,quantified
R6425 T8331 T8331 ROOT quantified,quantified
R6426 T8332 T8331 prep with,quantified
R6427 T8333 T8334 det a,phosphorimager
R6428 T8334 T8332 pobj phosphorimager,with
R6429 T8335 T8331 cc and,quantified
R6430 T8336 T8331 conj normalized,quantified
R6431 T8337 T8336 prep to,normalized
R6432 T8338 T8341 det the,gene
R6433 T8339 T8341 amod ribosomal,gene
R6434 T8340 T8341 compound housekeeping,gene
R6435 T8341 T8337 pobj gene,to
R6436 T8342 T8341 appos L32,gene
R6437 T8343 T8331 punct .,quantified
R6438 T8344 T8350 nsubjpass None,detected
R6439 T8345 T8344 prep of,None
R6440 T8346 T8348 det the,cytokines
R6441 T8347 T8348 amod tested,cytokines
R6442 T8348 T8345 pobj cytokines,of
R6443 T8349 T8350 auxpass were,detected
R6444 T8350 T8350 ROOT detected,detected
R6445 T8351 T8350 prep in,detected
R6446 T8352 T8353 amod wild-type,lymphocytes
R6447 T8353 T8351 pobj lymphocytes,in
R6448 T8354 T8350 punct ",",detected
R6449 T8355 T8356 advmod therefore,cytokine
R6450 T8356 T8356 ROOT cytokine,cytokine
R6451 T8357 T8356 punct :,cytokine
R6452 T8358 T8359 amod L32,ratios
R6453 T8359 T8361 nsubjpass ratios,set
R6454 T8360 T8361 auxpass were,set
R6455 T8361 T8350 advcl set,detected
R6456 T8362 T8361 prep to,set
R6457 T8363 T8362 pobj 1,to
R6458 T8364 T8361 prep in,set
R6459 T8365 T8370 det the,line
R6460 T8366 T8368 compound mouse,cell
R6461 T8367 T8368 compound B,cell
R6462 T8368 T8369 compound cell,lymphoma
R6463 T8369 T8370 compound lymphoma,line
R6464 T8370 T8364 pobj line,in
R6465 T8371 T8370 nummod 967,line
R6466 T8372 T8361 punct .,set
R6467 T8373 T8383 nsubjpass Transcription,detected
R6468 T8374 T8373 prep of,Transcription
R6469 T8375 T8374 pobj IL10,of
R6470 T8376 T8375 punct ",",IL10
R6471 T8377 T8375 conj IL15,IL10
R6472 T8378 T8377 punct ",",IL15
R6473 T8379 T8377 cc and,IL15
R6474 T8380 T8377 conj IFNγ,IL15
R6475 T8381 T8383 auxpass were,detected
R6476 T8382 T8383 advmod reproducibly,detected
R6477 T8383 T8383 ROOT detected,detected
R6478 T8384 T8383 prep in,detected
R6479 T8385 T8387 nummod LMP1,lymphocytes
R6480 T8386 T8387 amod transgenic,lymphocytes
R6481 T8387 T8384 pobj lymphocytes,in
R6482 T8388 T8387 cc and,lymphocytes
R6483 T8389 T8390 compound lymphoma,cells
R6484 T8390 T8387 conj cells,lymphocytes
R6485 T8391 T8383 cc and,detected
R6486 T8392 T8383 conj was,detected
R6487 T8393 T8392 acomp higher,was
R6488 T8394 T8393 prep than,higher
R6489 T8395 T8394 prep in,than
R6490 T8396 T8398 det the,cell
R6491 T8397 T8398 compound B,cell
R6492 T8398 T8400 compound cell,cell
R6493 T8399 T8400 compound lymphoma,cell
R6494 T8400 T8401 compound cell,lines
R6495 T8401 T8395 pobj lines,in
R6496 T8402 T8394 pobj 967,than
R6497 T8403 T8402 cc and,967
R6498 T8404 T8402 conj K46μ,967
R6499 T8405 T8407 punct (,5A
R6500 T8406 T8407 compound Figure,5A
R6501 T8407 T8404 appos 5A,K46μ
R6502 T8408 T8404 punct ),K46μ
R6503 T8409 T8383 punct .,detected
R6504 T8410 T8411 expl There,was
R6505 T8411 T8411 ROOT was,was
R6506 T8412 T8414 det no,difference
R6507 T8413 T8414 amod significant,difference
R6508 T8414 T8411 attr difference,was
R6509 T8415 T8414 prep in,difference
R6510 T8416 T8417 det the,expression
R6511 T8417 T8415 pobj expression,in
R6512 T8418 T8417 prep of,expression
R6513 T8419 T8418 pobj IL15,of
R6514 T8420 T8419 cc and,IL15
R6515 T8421 T8419 conj IFNγ,IL15
R6516 T8422 T8417 prep between,expression
R6517 T8423 T8425 nmod LMP1,lymphocytes
R6518 T8424 T8425 amod transgenic,lymphocytes
R6519 T8425 T8422 pobj lymphocytes,between
R6520 T8426 T8425 cc and,lymphocytes
R6521 T8427 T8428 compound lymphoma,cells
R6522 T8428 T8425 conj cells,lymphocytes
R6523 T8429 T8411 punct ",",was
R6524 T8430 T8411 advcl suggesting,was
R6525 T8431 T8438 mark that,induced
R6526 T8432 T8438 nsubjpass upregulation,induced
R6527 T8433 T8432 prep of,upregulation
R6528 T8434 T8433 pobj IL15,of
R6529 T8435 T8432 cc and,upregulation
R6530 T8436 T8432 conj IFNγ,upregulation
R6531 T8437 T8438 auxpass is,induced
R6532 T8438 T8430 ccomp induced,suggesting
R6533 T8439 T8438 prep by,induced
R6534 T8440 T8441 nummod LMP1,expression
R6535 T8441 T8439 pobj expression,by
R6536 T8442 T8438 prep in,induced
R6537 T8443 T8444 amod healthy,lymphocytes
R6538 T8444 T8442 pobj lymphocytes,in
R6539 T8445 T8438 cc but,induced
R6540 T8446 T8438 conj is,induced
R6541 T8447 T8446 neg not,is
R6542 T8448 T8450 det a,property
R6543 T8449 T8450 amod unique,property
R6544 T8450 T8446 attr property,is
R6545 T8451 T8450 prep of,property
R6546 T8452 T8453 amod malignant,lymphocytes
R6547 T8453 T8451 pobj lymphocytes,of
R6548 T8454 T8411 punct .,was
R6549 T8455 T8466 advmod Strikingly,increased
R6550 T8456 T8466 punct ",",increased
R6551 T8457 T8466 nsubj IL10,increased
R6552 T8458 T8457 punct ",",IL10
R6553 T8459 T8463 det a,cytokine
R6554 T8460 T8463 nmod B,cytokine
R6555 T8461 T8463 nmod lymphocyte,cytokine
R6556 T8462 T8463 amod stimulatory,cytokine
R6557 T8463 T8457 appos cytokine,IL10
R6558 T8464 T8466 punct ",",increased
R6559 T8465 T8466 auxpass was,increased
R6560 T8466 T8466 ROOT increased,increased
R6561 T8467 T8479 meta 1.5,compared
R6562 T8468 T8479 punct -,compared
R6563 T8469 T8479 prep to,compared
R6564 T8470 T8469 pobj 5-fold,to
R6565 T8471 T8470 prep in,5-fold
R6566 T8472 T8478 det the,cells
R6567 T8473 T8478 amod wild-type,cells
R6568 T8474 T8473 cc and,wild-type
R6569 T8475 T8473 conj LMP1,wild-type
R6570 T8476 T8478 amod transgenic,cells
R6571 T8477 T8478 compound lymphoma,cells
R6572 T8478 T8471 pobj cells,in
R6573 T8479 T8466 prep compared,increased
R6574 T8480 T8479 prep to,compared
R6575 T8481 T8483 nummod LMP1,lymphocytes
R6576 T8482 T8483 amod transgenic,lymphocytes
R6577 T8483 T8480 pobj lymphocytes,to
R6578 T8484 T8486 punct (,5A
R6579 T8485 T8486 compound Figure,5A
R6580 T8486 T8483 appos 5A,lymphocytes
R6581 T8487 T8479 punct ),compared
R6582 T8488 T8466 punct .,increased
R6583 T8489 T8496 nsubjpass Production,associated
R6584 T8490 T8489 prep of,Production
R6585 T8491 T8490 pobj IL15,of
R6586 T8492 T8489 cc and,Production
R6587 T8493 T8489 conj IFNγ,Production
R6588 T8494 T8496 aux has,associated
R6589 T8495 T8496 auxpass been,associated
R6590 T8496 T8496 ROOT associated,associated
R6591 T8497 T8496 prep with,associated
R6592 T8498 T8497 pobj induction,with
R6593 T8499 T8498 prep of,induction
R6594 T8500 T8502 amod cytotoxic,responses
R6595 T8501 T8502 compound effector,responses
R6596 T8502 T8499 pobj responses,of
R6597 T8503 T8502 prep in,responses
R6598 T8504 T8503 pobj cells,in
R6599 T8505 T8506 advmod latently,infected
R6600 T8506 T8504 acl infected,cells
R6601 T8507 T8506 prep with,infected
R6602 T8508 T8509 compound EBV,[
R6603 T8509 T8507 pobj [,with
R6604 T8510 T8511 nummod "33,34",]
R6605 T8511 T8509 appos ],[
R6606 T8512 T8496 punct .,associated
R6607 T8513 T8523 advmod However,associated
R6608 T8514 T8523 punct ",",associated
R6609 T8515 T8518 nmod transformation,properties
R6610 T8516 T8515 cc and,transformation
R6611 T8517 T8515 conj growth,transformation
R6612 T8518 T8523 nsubjpass properties,associated
R6613 T8519 T8518 acl induced,properties
R6614 T8520 T8519 agent by,induced
R6615 T8521 T8520 pobj EBV,by
R6616 T8522 T8523 auxpass are,associated
R6617 T8523 T8551 ccomp associated,examined
R6618 T8524 T8523 prep with,associated
R6619 T8525 T8526 det the,upregulation
R6620 T8526 T8524 pobj upregulation,with
R6621 T8527 T8526 prep of,upregulation
R6622 T8528 T8529 compound IL10,[
R6623 T8529 T8527 pobj [,of
R6624 T8530 T8529 nummod 35,[
R6625 T8531 T8532 nummod 38,]
R6626 T8532 T8529 appos ],[
R6627 T8533 T8551 punct ;,examined
R6628 T8534 T8551 advmod hence,examined
R6629 T8535 T8551 punct ",",examined
R6630 T8536 T8537 det the,effects
R6631 T8537 T8551 nsubjpass effects,examined
R6632 T8538 T8537 prep of,effects
R6633 T8539 T8540 compound IL10,upregulation
R6634 T8540 T8538 pobj upregulation,of
R6635 T8541 T8540 prep on,upregulation
R6636 T8542 T8544 det the,properties
R6637 T8543 T8544 compound growth,properties
R6638 T8544 T8541 pobj properties,on
R6639 T8545 T8544 prep of,properties
R6640 T8546 T8548 det the,cells
R6641 T8547 T8548 compound lymphoma,cells
R6642 T8548 T8545 pobj cells,of
R6643 T8549 T8551 auxpass were,examined
R6644 T8550 T8551 advmod further,examined
R6645 T8551 T8551 ROOT examined,examined
R6646 T8552 T8551 punct .,examined
R6647 T8553 T8554 compound Immunoblot,analysis
R6648 T8554 T8555 nsubj analysis,indicated
R6649 T8555 T8555 ROOT indicated,indicated
R6650 T8556 T8567 mark that,had
R6651 T8557 T8559 nummod LMP1,lymphocytes
R6652 T8558 T8559 amod transgenic,lymphocytes
R6653 T8559 T8567 nsubj lymphocytes,had
R6654 T8560 T8559 cc and,lymphocytes
R6655 T8561 T8559 conj wild-type,lymphocytes
R6656 T8562 T8561 cc and,wild-type
R6657 T8563 T8561 conj LMP1,wild-type
R6658 T8564 T8566 amod transgenic,cells
R6659 T8565 T8566 compound lymphoma,cells
R6660 T8566 T8559 conj cells,lymphocytes
R6661 T8567 T8555 ccomp had,indicated
R6662 T8568 T8570 amod corresponding,levels
R6663 T8569 T8570 amod increased,levels
R6664 T8570 T8567 dobj levels,had
R6665 T8571 T8570 prep of,levels
R6666 T8572 T8573 amod phosphorylated,α
R6667 T8573 T8571 pobj α,of
R6668 T8574 T8573 cc and,α
R6669 T8575 T8576 compound β,isoforms
R6670 T8576 T8573 conj isoforms,α
R6671 T8577 T8576 prep of,isoforms
R6672 T8578 T8579 amod activated,Stat3
R6673 T8579 T8577 pobj Stat3,of
R6674 T8580 T8579 punct ",",Stat3
R6675 T8581 T8582 det a,target
R6676 T8582 T8579 appos target,Stat3
R6677 T8583 T8582 prep of,target
R6678 T8584 T8586 det the,receptor
R6679 T8585 T8586 compound IL10,receptor
R6680 T8586 T8583 pobj receptor,of
R6681 T8587 T8589 punct (,5B
R6682 T8588 T8589 compound Figure,5B
R6683 T8589 T8586 appos 5B,receptor
R6684 T8590 T8589 punct ),5B
R6685 T8591 T8555 punct .,indicated
R6686 T8592 T8601 advmod However,was
R6687 T8593 T8601 punct ",",was
R6688 T8594 T8595 advmod when,comparing
R6689 T8595 T8601 advcl comparing,was
R6690 T8596 T8598 det the,lymphomas
R6691 T8597 T8598 amod same,lymphomas
R6692 T8598 T8595 dobj lymphomas,comparing
R6693 T8599 T8601 punct ",",was
R6694 T8600 T8601 expl there,was
R6695 T8601 T8601 ROOT was,was
R6696 T8602 T8603 det no,correlation
R6697 T8603 T8601 attr correlation,was
R6698 T8604 T8603 prep between,correlation
R6699 T8605 T8606 det the,levels
R6700 T8606 T8604 pobj levels,between
R6701 T8607 T8606 prep of,levels
R6702 T8608 T8609 compound IL10,induction
R6703 T8609 T8607 pobj induction,of
R6704 T8610 T8606 cc and,levels
R6705 T8611 T8612 det the,levels
R6706 T8612 T8606 conj levels,levels
R6707 T8613 T8612 prep of,levels
R6708 T8614 T8615 amod Stat3,activation
R6709 T8615 T8613 pobj activation,of
R6710 T8616 T8601 punct .,was
R6711 T8617 T8618 nsubj This,suggests
R6712 T8618 T8618 ROOT suggests,suggests
R6713 T8619 T8624 mark that,is
R6714 T8620 T8621 det the,activation
R6715 T8621 T8624 nsubj activation,is
R6716 T8622 T8621 prep of,activation
R6717 T8623 T8622 pobj Stat3,of
R6718 T8624 T8627 auxpass is,induced
R6719 T8625 T8627 neg not,induced
R6720 T8626 T8627 advmod solely,induced
R6721 T8627 T8618 ccomp induced,suggests
R6722 T8628 T8627 agent by,induced
R6723 T8629 T8628 pobj IL10,by
R6724 T8630 T8629 cc or,IL10
R6725 T8631 T8633 det that,activation
R6726 T8632 T8633 amod Stat3,activation
R6727 T8633 T8635 nsubj activation,be
R6728 T8634 T8635 aux may,be
R6729 T8635 T8618 ccomp be,suggests
R6730 T8636 T8635 acomp constitutive,be
R6731 T8637 T8618 punct .,suggests
R6732 T8638 T8641 advmod Additionally,was
R6733 T8639 T8641 punct ",",was
R6734 T8640 T8641 expl there,was
R6735 T8641 T8641 ROOT was,was
R6736 T8642 T8643 det no,correlation
R6737 T8643 T8641 attr correlation,was
R6738 T8644 T8643 prep between,correlation
R6739 T8645 T8646 det the,levels
R6740 T8646 T8644 pobj levels,between
R6741 T8647 T8646 prep of,levels
R6742 T8648 T8649 nummod LMP1,expression
R6743 T8649 T8647 pobj expression,of
R6744 T8650 T8649 cc and,expression
R6745 T8651 T8652 det the,levels
R6746 T8652 T8649 conj levels,expression
R6747 T8653 T8652 prep of,levels
R6748 T8654 T8655 compound IL10,induction
R6749 T8655 T8653 pobj induction,of
R6750 T8656 T8658 punct (,1A
R6751 T8657 T8658 compound Figures,1A
R6752 T8658 T8655 appos 1A,induction
R6753 T8659 T8658 cc and,1A
R6754 T8660 T8658 conj 5A,1A
R6755 T8661 T8658 punct ),1A
R6756 T8662 T8641 punct .,was
R6757 T8663 T8664 nsubj This,indicates
R6758 T8664 T8664 ROOT indicates,indicates
R6759 T8665 T8670 mark that,is
R6760 T8666 T8667 det the,induction
R6761 T8667 T8670 nsubj induction,is
R6762 T8668 T8667 prep of,induction
R6763 T8669 T8668 pobj IL10,of
R6764 T8670 T8664 ccomp is,indicates
R6765 T8671 T8673 det a,property
R6766 T8672 T8673 amod general,property
R6767 T8673 T8670 attr property,is
R6768 T8674 T8673 acl associated,property
R6769 T8675 T8674 prep with,associated
R6770 T8676 T8677 amod enhanced,survival
R6771 T8677 T8675 pobj survival,with
R6772 T8678 T8670 cc and,is
R6773 T8679 T8683 aux may,affected
R6774 T8680 T8681 advmod only,be
R6775 T8681 T8683 auxpass be,affected
R6776 T8682 T8683 advmod indirectly,affected
R6777 T8683 T8670 conj affected,is
R6778 T8684 T8683 agent by,affected
R6779 T8685 T8684 pobj LMP1,by
R6780 T8686 T8664 punct .,indicates
R6781 T8687 T8693 csubj Neutralizing,affect
R6782 T8688 T8687 dobj antibodies,Neutralizing
R6783 T8689 T8687 prep to,Neutralizing
R6784 T8690 T8689 pobj IL10,to
R6785 T8691 T8693 aux did,affect
R6786 T8692 T8693 neg not,affect
R6787 T8693 T8693 ROOT affect,affect
R6788 T8694 T8695 det the,survival
R6789 T8695 T8693 dobj survival,affect
R6790 T8696 T8695 prep of,survival
R6791 T8697 T8698 compound lymphoma,cells
R6792 T8698 T8696 pobj cells,of
R6793 T8699 T8700 mark as,determined
R6794 T8700 T8693 advcl determined,affect
R6795 T8701 T8700 agent by,determined
R6796 T8702 T8704 det the,assay
R6797 T8703 T8704 compound MTS,assay
R6798 T8704 T8701 pobj assay,by
R6799 T8705 T8704 punct (,assay
R6800 T8706 T8707 amod unpublished,data
R6801 T8707 T8704 appos data,assay
R6802 T8708 T8704 punct ),assay
R6803 T8709 T8693 punct ",",affect
R6804 T8710 T8693 advcl suggesting,affect
R6805 T8711 T8712 amod constitutive,activation
R6806 T8712 T8710 dobj activation,suggesting
R6807 T8713 T8712 prep of,activation
R6808 T8714 T8713 pobj Stat3,of
R6809 T8715 T8693 punct .,affect
R6810 T8716 T8718 nsubjpass This,confirmed
R6811 T8717 T8718 auxpass was,confirmed
R6812 T8718 T8718 ROOT confirmed,confirmed
R6813 T8719 T8718 agent by,confirmed
R6814 T8720 T8721 compound immunoblot,analysis
R6815 T8721 T8719 pobj analysis,by
R6816 T8722 T8734 amod such,remained
R6817 T8723 T8734 mark that,remained
R6818 T8724 T8734 prep in,remained
R6819 T8725 T8726 det the,presence
R6820 T8726 T8724 pobj presence,in
R6821 T8727 T8726 prep of,presence
R6822 T8728 T8729 advmod anti-IL10,neutralizing
R6823 T8729 T8727 pcomp neutralizing,of
R6824 T8730 T8729 dobj antibodies,neutralizing
R6825 T8731 T8734 punct ",",remained
R6826 T8732 T8733 amod pStat3,levels
R6827 T8733 T8734 nsubj levels,remained
R6828 T8734 T8735 aux remained,activated
R6829 T8735 T8718 conj activated,confirmed
R6830 T8736 T8735 prep in,activated
R6831 T8737 T8738 compound lymphoma,cells
R6832 T8738 T8736 pobj cells,in
R6833 T8739 T8738 acl isolated,cells
R6834 T8740 T8739 prep from,isolated
R6835 T8741 T8745 nmod wild-type,lymphomas
R6836 T8742 T8741 cc and,wild-type
R6837 T8743 T8741 conj LMP1,wild-type
R6838 T8744 T8745 amod transgenic,lymphomas
R6839 T8745 T8740 pobj lymphomas,from
R6840 T8746 T8748 punct (,5C
R6841 T8747 T8748 compound Figure,5C
R6842 T8748 T8745 appos 5C,lymphomas
R6843 T8749 T8745 punct ),lymphomas
R6844 T8750 T8718 punct .,confirmed
R6845 T8751 T8752 amod Exogenous,addition
R6846 T8752 T8752 ROOT addition,addition
R6847 T8753 T8752 prep of,addition
R6848 T8754 T8757 nummod IL10,activation
R6849 T8755 T8757 amod enhanced,activation
R6850 T8756 T8757 amod pStat3,activation
R6851 T8757 T8753 pobj activation,of
R6852 T8758 T8757 prep above,activation
R6853 T8759 T8760 amod constitutive,levels
R6854 T8760 T8758 pobj levels,above
R6855 T8761 T8752 punct ",",addition
R6856 T8762 T8752 acl indicating,addition
R6857 T8763 T8766 mark that,are
R6858 T8764 T8765 compound lymphoma,cells
R6859 T8765 T8766 nsubj cells,are
R6860 T8766 T8762 ccomp are,indicating
R6861 T8767 T8766 acomp responsive,are
R6862 T8768 T8767 prep to,responsive
R6863 T8769 T8770 amod IL10,treatment
R6864 T8770 T8768 pobj treatment,to
R6865 T8771 T8773 punct (,5C
R6866 T8772 T8773 compound Figure,5C
R6867 T8773 T8770 appos 5C,treatment
R6868 T8774 T8752 punct ),addition
R6869 T8775 T8752 punct .,addition
R6870 T8776 T8777 nsubj This,means
R6871 T8777 T8777 ROOT means,means
R6872 T8778 T8792 mark that,enhanced
R6873 T8779 T8783 mark although,have
R6874 T8780 T8782 det the,cells
R6875 T8781 T8782 compound lymphoma,cells
R6876 T8782 T8783 nsubj cells,have
R6877 T8783 T8792 advcl have,enhanced
R6878 T8784 T8786 amod constitutive,activation
R6879 T8785 T8786 amod Stat3,activation
R6880 T8786 T8783 dobj activation,have
R6881 T8787 T8792 punct ",",enhanced
R6882 T8788 T8792 nsubjpass it,enhanced
R6883 T8789 T8792 aux may,enhanced
R6884 T8790 T8792 auxpass be,enhanced
R6885 T8791 T8792 advmod further,enhanced
R6886 T8792 T8777 ccomp enhanced,means
R6887 T8793 T8792 agent by,enhanced
R6888 T8794 T8795 compound IL10,induction
R6889 T8795 T8793 pobj induction,by
R6890 T8796 T8777 punct .,means
R6891 T8797 T8799 det The,effect
R6892 T8798 T8799 amod neutralizing,effect
R6893 T8799 T8805 nsubjpass effect,confirmed
R6894 T8800 T8799 prep of,effect
R6895 T8801 T8803 det the,antibody
R6896 T8802 T8803 amod anti-IL10,antibody
R6897 T8803 T8800 pobj antibody,of
R6898 T8804 T8805 auxpass was,confirmed
R6899 T8805 T8805 ROOT confirmed,confirmed
R6900 T8806 T8805 agent by,confirmed
R6901 T8807 T8806 pobj pre-incubation,by
R6902 T8808 T8807 prep of,pre-incubation
R6903 T8809 T8808 pobj IL10,of
R6904 T8810 T8809 prep with,IL10
R6905 T8811 T8812 amod anti-IL10,antibody
R6907 T8813 T8805 prep compared,confirmed
R6908 T8814 T8813 prep to,compared
R6909 T8815 T8819 det a,control
R6910 T8816 T8819 nmod rat,control
R6911 T8817 T8819 amod IgG1,control
R6912 T8818 T8819 compound isotype,control
R6913 T8819 T8814 pobj control,to
R6914 T8820 T8822 punct (,5C
R6915 T8821 T8822 compound Figure,5C
R6916 T8822 T8819 appos 5C,control
R6917 T8823 T8822 punct ),5C
R6918 T8824 T8805 punct .,confirmed
R6919 T8825 T8826 compound Nuclear,translocation
R6920 T8826 T8829 nsubj translocation,is
R6921 T8827 T8826 prep of,translocation
R6922 T8828 T8827 pobj pStat3,of
R6923 T8829 T8829 ROOT is,is
R6924 T8830 T8831 det a,consequence
R6925 T8831 T8829 attr consequence,is
R6926 T8832 T8831 prep of,consequence
R6927 T8833 T8832 pobj activation,of
R6928 T8834 T8831 punct ",",consequence
R6929 T8835 T8831 cc and,consequence
R6930 T8836 T8837 amod nuclear,pStat3
R6931 T8837 T8831 conj pStat3,consequence
R6932 T8838 T8840 auxpass was,detected
R6933 T8839 T8840 neg not,detected
R6934 T8840 T8829 conj detected,is
R6935 T8841 T8840 agent by,detected
R6936 T8842 T8841 pobj immunohistochemistry,by
R6937 T8843 T8840 conj staining,detected
R6938 T8844 T8843 prep of,staining
R6939 T8845 T8846 compound spleen,sections
R6940 T8846 T8844 pobj sections,of
R6941 T8847 T8846 prep from,sections
R6942 T8848 T8849 compound control,mice
R6943 T8849 T8847 pobj mice,from
R6944 T8850 T8829 punct .,is
R6945 T8851 T8855 advmod However,was
R6946 T8852 T8855 punct ",",was
R6947 T8853 T8854 amod nuclear,pStat3
R6948 T8854 T8855 nsubj pStat3,was
R6949 T8855 T8855 ROOT was,was
R6950 T8856 T8855 acomp detectable,was
R6951 T8857 T8855 prep in,was
R6952 T8858 T8860 nummod LMP1,mice
R6953 T8859 T8860 amod transgenic,mice
R6954 T8860 T8857 pobj mice,in
R6955 T8861 T8860 cc and,mice
R6956 T8862 T8863 amod wild-type,lymphomas
R6957 T8863 T8860 conj lymphomas,mice
R6958 T8864 T8855 cc and,was
R6959 T8865 T8866 auxpass was,detected
R6960 T8866 T8855 conj detected,was
R6961 T8867 T8868 advmod more,homogeneously
R6962 T8868 T8866 advmod homogeneously,detected
R6963 T8869 T8866 prep in,detected
R6964 T8870 T8872 nummod LMP1,lymphomas
R6965 T8871 T8872 amod transgenic,lymphomas
R6967 T8872 T8869 pobj lymphomas,in
R6968 T8873 T8874 punct (,Figure
R6969 T8874 T8872 appos Figure,lymphomas
R6970 T8875 T8874 nummod 5D,Figure
R6971 T8876 T8874 punct ),Figure
R6972 T8877 T8855 punct .,was
R6973 T8878 T8880 det The,activation
R6974 T8879 T8880 amod constitutive,activation
R6975 T8880 T8887 nsubj activation,suggests
R6976 T8881 T8880 prep of,activation
R6977 T8882 T8886 amod pStat3,Stat3
R6978 T8883 T8882 cc and,pStat3
R6979 T8884 T8882 conj abundant,pStat3
R6980 T8885 T8886 amod nuclear,Stat3
R6981 T8886 T8881 pobj Stat3,of
R6982 T8887 T8887 ROOT suggests,suggests
R6983 T8888 T8891 mark that,contributes
R6984 T8889 T8891 nsubj Stat3,contributes
R6985 T8890 T8891 nsubj signaling,contributes
R6986 T8891 T8887 ccomp contributes,suggests
R6987 T8892 T8891 prep to,contributes
R6988 T8893 T8895 amod LMP1-mediated,development
R6989 T8894 T8895 compound lymphoma,development
R6990 T8895 T8892 pobj development,to
R6991 T8896 T8887 punct .,suggests
R7982 T10502 T10507 nummod LMP1,Deregulates
R7983 T10503 T10504 compound Activates,Akt
R7984 T10504 T10507 compound Akt,Deregulates
R7985 T10505 T10507 amod Signaling,Deregulates
R7986 T10506 T10505 cc and,Signaling
R7987 T10507 T10507 ROOT Deregulates,Deregulates
R7988 T10508 T10514 det the,transformation
R7989 T10509 T10511 compound Rb,Cycle
R7990 T10510 T10511 compound Cell,Cycle
R7991 T10511 T10512 compound Cycle,Pathway
R7992 T10512 T10513 compound Pathway,LMP1
R7993 T10513 T10514 compound LMP1,transformation
R7994 T10514 T10507 dobj transformation,Deregulates
R7995 T10515 T10514 prep of,transformation
R7996 T10516 T10517 compound rodent,fibroblasts
R7997 T10517 T10515 pobj fibroblasts,of
R7998 T10518 T10507 conj requires,Deregulates
R7999 T10519 T10518 dobj activation,requires
R8000 T10520 T10519 prep of,activation
R8001 T10521 T10520 pobj PI3K,of
R8002 T10522 T10521 cc and,PI3K
R8003 T10523 T10524 compound Akt,[
R8004 T10524 T10507 appos [,Deregulates
R8005 T10525 T10526 nummod 5,]
R8006 T10526 T10524 appos ],[
R8007 T10527 T10507 punct .,Deregulates
R8008 T10528 T10534 advmod Additionally,detected
R8009 T10529 T10534 punct ",",detected
R8010 T10530 T10531 amod activated,pAkt
R8011 T10531 T10534 nsubjpass pAkt,detected
R8012 T10532 T10534 auxpass is,detected
R8013 T10533 T10534 advmod frequently,detected
R8014 T10534 T10534 ROOT detected,detected
R8015 T10535 T10534 prep in,detected
R8016 T10536 T10535 pobj NPC,in
R8017 T10537 T10536 cc and,NPC
R8018 T10538 T10541 det the,cells
R8019 T10539 T10541 amod neoplastic,cells
R8020 T10540 T10541 compound Reed-Sternberg,cells
R8021 T10541 T10536 conj cells,NPC
R8022 T10542 T10541 prep of,cells
R8023 T10543 T10545 amod classical,[
R8024 T10544 T10545 compound HD,[
R8025 T10545 T10542 pobj [,of
R8026 T10546 T10547 nummod "39,40",]
R8027 T10547 T10541 conj ],cells
R8028 T10548 T10534 punct .,detected
R8029 T10549 T10550 aux To,determine
R8030 T10550 T10550 ROOT determine,determine
R8031 T10551 T10553 mark if,signaling
R8032 T10552 T10553 compound Akt,signaling
R8033 T10553 T10555 nsubjpass signaling,activated
R8034 T10554 T10555 auxpass is,activated
R8035 T10555 T10550 ccomp activated,determine
R8036 T10556 T10555 prep in,activated
R8037 T10557 T10559 nummod LMP1,mice
R8038 T10558 T10559 amod transgenic,mice
R8039 T10559 T10556 pobj mice,in
R8040 T10560 T10559 punct ",",mice
R8041 T10561 T10568 nsubjpass pAkt,assessed
R8042 T10562 T10561 cc and,pAkt
R8043 T10563 T10561 conj several,pAkt
R8044 T10564 T10563 prep of,several
R8045 T10565 T10566 poss its,targets
R8046 T10566 T10564 pobj targets,of
R8047 T10567 T10568 auxpass were,assessed
R8048 T10568 T10555 advcl assessed,activated
R8049 T10569 T10568 agent by,assessed
R8050 T10570 T10569 pobj immunoblotting,by
R8051 T10571 T10570 prep of,immunoblotting
R8052 T10572 T10577 amod splenic,cells
R8053 T10573 T10576 compound CD19,B
R8054 T10574 T10576 compound +,B
R8055 T10575 T10576 compound MACS-purified,B
R8056 T10576 T10577 compound B,cells
R8057 T10577 T10571 pobj cells,of
R8058 T10578 T10550 punct .,determine
R8059 T10579 T10582 nummod LMP1,cells
R8060 T10580 T10582 amod transgenic,cells
R8061 T10581 T10582 compound B,cells
R8062 T10582 T10584 nsubj cells,increased
R8063 T10583 T10584 aux had,increased
R8064 T10584 T10609 ccomp increased,increase
R8065 T10585 T10584 dobj levels,increased
R8066 T10586 T10585 prep of,levels
R8067 T10587 T10586 pobj pAkt,of
R8068 T10588 T10584 prep compared,increased
R8069 T10589 T10588 prep to,compared
R8070 T10590 T10591 compound wild-type,lymphocytes
R8071 T10591 T10589 pobj lymphocytes,to
R8072 T10592 T10609 punct ;,increase
R8073 T10593 T10609 advmod however,increase
R8074 T10594 T10593 punct ",",however
R8075 T10595 T10609 nsubj progression,increase
R8076 T10596 T10609 prep to,increase
R8077 T10597 T10596 pobj lymphoma,to
R8078 T10598 T10597 prep in,lymphoma
R8079 T10599 T10600 det both,LMP1-positive
R8080 T10600 T10598 pobj LMP1-positive,in
R8081 T10601 T10600 cc and,LMP1-positive
R8082 T10602 T10603 punct -,negative
R8083 T10603 T10605 amod negative,cells
R8084 T10604 T10605 compound lymphoma,cells
R8085 T10605 T10609 nsubj cells,increase
R8086 T10606 T10609 aux did,increase
R8087 T10607 T10608 neg not,further
R8088 T10608 T10609 advmod further,increase
R8089 T10609 T10609 ROOT increase,increase
R8090 T10610 T10611 compound pAkt,levels
R8091 T10611 T10609 dobj levels,increase
R8092 T10612 T10609 punct .,increase
R8093 T10613 T10624 det The,inactivated
R8094 T10614 T10624 nsubjpass Akt,inactivated
R8095 T10615 T10616 compound target,glycogen
R8096 T10616 T10624 nsubjpass glycogen,inactivated
R8097 T10617 T10618 compound synthase,kinase
R8098 T10618 T10616 appos kinase,glycogen
R8099 T10619 T10618 nummod 3,kinase
R8100 T10620 T10621 punct (,GSK3
R8101 T10621 T10618 appos GSK3,kinase
R8102 T10622 T10618 punct ),kinase
R8103 T10623 T10624 auxpass is,inactivated
R8104 T10624 T10630 ccomp inactivated,increased
R8105 T10625 T10624 agent by,inactivated
R8106 T10626 T10625 pobj phosphorylation,by
R8107 T10627 T10630 punct ;,increased
R8108 T10628 T10630 advmod however,increased
R8109 T10629 T10630 punct ",",increased
R8110 T10630 T10630 ROOT increased,increased
R8111 T10631 T10632 compound phosphorylated,GSK3
R8112 T10632 T10635 nsubjpass GSK3,detected
R8113 T10633 T10635 auxpass was,detected
R8114 T10634 T10635 neg not,detected
R8115 T10635 T10630 ccomp detected,increased
R8116 T10636 T10635 prep in,detected
R8117 T10637 T10639 det the,lymphocytes
R8133 T10653 T10654 det This,finding
R8134 T10654 T10655 nsubj finding,indicates
R8135 T10655 T10655 ROOT indicates,indicates
R8136 T10656 T10658 mark that,is
R8137 T10657 T10658 nsubj GSK3,is
R8138 T10658 T10655 ccomp is,indicates
R8139 T10659 T10658 neg not,is
R8140 T10660 T10661 det a,target
R8141 T10661 T10658 attr target,is
R8142 T10662 T10661 prep of,target
R8143 T10663 T10664 amod activated,Akt
R8144 T10664 T10662 pobj Akt,of
R8145 T10665 T10664 prep in,Akt
R8146 T10666 T10669 det the,lymphocytes
R8147 T10667 T10669 compound LMP1,lymphocytes
R8148 T10668 T10669 compound transgenic,lymphocytes
R8149 T10669 T10665 pobj lymphocytes,in
R8150 T10670 T10669 cc and,lymphocytes
R8151 T10671 T10672 compound lymphoma,cells
R8152 T10672 T10669 conj cells,lymphocytes
R8153 T10673 T10655 punct .,indicates
R8154 T10674 T10686 advmod Similarly,shown
R8155 T10675 T10686 punct ",",shown
R8156 T10676 T10686 nsubjpass activation,shown
R8157 T10677 T10676 prep of,activation
R8158 T10678 T10677 pobj Akt,of
R8159 T10679 T10676 prep without,activation
R8160 T10680 T10679 pobj phosphorylation,without
R8161 T10681 T10680 prep of,phosphorylation
R8162 T10682 T10681 pobj GSK3,of
R8163 T10683 T10686 aux has,shown
R8164 T10684 T10686 auxpass been,shown
R8165 T10685 T10686 advmod previously,shown
R8166 T10686 T10686 ROOT shown,shown
R8167 T10687 T10686 prep in,shown
R8168 T10688 T10690 amod EBV-positive,[
R8169 T10689 T10690 compound HD,[
R8170 T10690 T10687 pobj [,in
R8171 T10691 T10692 nummod 40,]
R8172 T10692 T10686 dobj ],shown
R8173 T10693 T10686 punct .,shown
R8174 T10694 T10700 prep In,lacked
R8175 T10695 T10694 pobj contrast,In
R8176 T10696 T10700 punct ",",lacked
R8177 T10697 T10699 det the,lymphocytes
R8178 T10698 T10699 amod wild-type,lymphocytes
R8179 T10699 T10700 nsubj lymphocytes,lacked
R8180 T10700 T10700 ROOT lacked,lacked
R8181 T10701 T10700 conj activated,lacked
R8183 T10703 T10701 cc but,activated
R8184 T10704 T10705 aux did,have
R8185 T10705 T10701 conj have,activated
R8186 T10706 T10708 amod detectable,GSK3
R8187 T10707 T10708 compound phosphorylated,GSK3
R8188 T10708 T10705 dobj GSK3,have
R8189 T10709 T10700 punct .,lacked
R8190 T10710 T10712 nsubj This,suggests
R8191 T10711 T10712 advmod further,suggests
R8192 T10712 T10712 ROOT suggests,suggests
R8193 T10713 T10717 mark that,involved
R8194 T10714 T10715 amod additional,pathways
R8195 T10715 T10717 nsubjpass pathways,involved
R8196 T10716 T10717 auxpass are,involved
R8197 T10717 T10712 ccomp involved,suggests
R8198 T10718 T10717 prep in,involved
R8199 T10719 T10720 det the,regulation
R8200 T10720 T10718 pobj regulation,in
R8201 T10721 T10720 prep of,regulation
R8202 T10722 T10721 pobj GSK3,of
R8203 T10723 T10712 punct .,suggests
R8204 T10724 T10725 aux To,identify
R8205 T10725 T10736 advcl identify,performed
R8206 T10726 T10729 amod other,targets
R8207 T10727 T10729 amod potential,targets
R8208 T10728 T10729 compound Akt,targets
R8209 T10729 T10725 dobj targets,identify
R8210 T10730 T10729 punct ",",targets
R8211 T10731 T10732 compound immunoblot,analysis
R8212 T10732 T10736 nsubjpass analysis,performed
R8213 T10733 T10732 prep for,analysis
R8214 T10734 T10733 pobj p-mTOR,for
R8215 T10735 T10736 auxpass was,performed
R8216 T10736 T10736 ROOT performed,performed
R8217 T10737 T10736 punct .,performed
R8218 T10738 T10739 amod Activated,p-mTOR
R8219 T10739 T10742 nsubjpass p-mTOR,increased
R8220 T10740 T10742 auxpass was,increased
R8221 T10741 T10742 neg not,increased
R8222 T10742 T10742 ROOT increased,increased
R8223 T10743 T10742 prep in,increased
R8224 T10744 T10746 nummod LMP1,lymphocytes
R8225 T10745 T10746 amod transgenic,lymphocytes
R8226 T10746 T10743 pobj lymphocytes,in
R8227 T10747 T10746 cc or,lymphocytes
R8228 T10748 T10749 compound lymphoma,cells
R8229 T10749 T10746 conj cells,lymphocytes
R8230 T10750 T10742 punct ",",increased
R8231 T10751 T10742 advcl indicating,increased
R8232 T10752 T10757 mark that,affected
R8233 T10753 T10754 det this,pathway
R8234 T10754 T10757 nsubjpass pathway,affected
R8235 T10755 T10757 auxpass is,affected
R8236 T10756 T10757 neg not,affected
R8237 T10757 T10751 ccomp affected,indicating
R8238 T10758 T10757 agent by,affected
R8239 T10759 T10761 amod LMP1-induced,activation
R8240 T10760 T10761 compound Akt,activation
R8241 T10761 T10758 pobj activation,by
R8242 T10762 T10757 cc and,affected
R8243 T10763 T10765 aux does,contribute
R8244 T10764 T10765 neg not,contribute
R8245 T10765 T10757 conj contribute,affected
R8246 T10766 T10765 prep to,contribute
R8247 T10767 T10768 compound lymphoma,development
R8248 T10768 T10766 pobj development,to
R8249 T10769 T10771 punct (,6B
R8250 T10770 T10771 compound Figure,6B
R8251 T10771 T10768 appos 6B,development
R8252 T10772 T10771 punct ),6B
R8253 T10773 T10742 punct .,increased
R8254 T10774 T10777 nsubjpass Akt,known
R8255 T10775 T10777 auxpass is,known
R8256 T10776 T10777 advmod also,known
R8257 T10777 T10777 ROOT known,known
R8258 T10778 T10779 aux to,phosphorylate
R8259 T10779 T10777 xcomp phosphorylate,known
R8260 T10780 T10779 cc and,phosphorylate
R8261 T10781 T10779 conj induce,phosphorylate
R8262 T10782 T10783 det the,degradation
R8263 T10783 T10781 dobj degradation,induce
R8264 T10784 T10783 prep of,degradation
R8265 T10785 T10788 det the,family
R8266 T10786 T10788 amod pro-apoptotic,family
R8267 T10787 T10788 compound Forkhead,family
R8268 T10788 T10784 pobj family,of
R8269 T10789 T10788 prep of,family
R8270 T10790 T10791 compound transcription,factors
R8271 T10791 T10789 pobj factors,of
R8272 T10792 T10781 punct ",",induce
R8273 T10793 T10781 advcl leading,induce
R8274 T10794 T10793 prep to,leading
R8275 T10795 T10796 compound cell,cycle
R8276 T10796 T10797 compound cycle,progression
R8277 T10797 T10794 pobj progression,to
R8278 T10798 T10797 cc and,progression
R8279 T10799 T10797 conj survival,progression
R8280 T10800 T10793 prep in,leading
R8281 T10801 T10803 det some,tumors
R8282 T10802 T10803 amod human,tumors
R8283 T10803 T10800 pobj tumors,in
R8284 T10804 T10806 compound [,]
R8285 T10805 T10806 compound "41,42",]
R8286 T10806 T10806 ROOT ],]
R8287 T10807 T10777 punct .,known
R8288 T10808 T10809 compound Immunoblot,analysis
R8289 T10809 T10817 nsubj analysis,detect
R8290 T10810 T10809 prep of,analysis
R8291 T10811 T10813 amod splenic,cells
R8292 T10812 T10813 compound B,cells
R8293 T10813 T10810 pobj cells,of
R8294 T10814 T10817 aux did,detect
R8295 T10815 T10817 neg not,detect
R8296 T10816 T10817 advmod consistently,detect
R8297 T10817 T10817 ROOT detect,detect
R8298 T10818 T10819 amod p-FoxO1,levels
R8299 T10819 T10817 dobj levels,detect
R8300 T10820 T10817 punct ",",detect
R8301 T10821 T10822 det a,signal
R8302 T10822 T10817 dobj signal,detect
R8303 T10823 T10824 nsubj that,targets
R8304 T10824 T10822 relcl targets,signal
R8305 T10825 T10824 dobj FoxO1,targets
R8306 T10826 T10824 prep for,targets
R8307 T10827 T10826 pobj degradation,for
R8308 T10828 T10817 punct .,detect
R8309 T10829 T10835 advmod Hence,assessed
R8310 T10830 T10835 punct ",",assessed
R8311 T10831 T10835 nsubjpass degradation,assessed
R8312 T10832 T10831 prep of,degradation
R8313 T10833 T10832 pobj FoxO1,of
R8314 T10834 T10835 auxpass was,assessed
R8315 T10835 T10835 ROOT assessed,assessed
R8316 T10836 T10835 agent by,assessed
R8317 T10837 T10836 pobj detection,by
R8318 T10838 T10837 prep of,detection
R8319 T10839 T10841 amod total,levels
R8320 T10840 T10841 amod FoxO1,levels
R8321 T10841 T10838 pobj levels,of
R8322 T10842 T10835 punct .,assessed
R8323 T10843 T10844 compound Immunoblot,analysis
R8324 T10844 T10845 nsubj analysis,indicated
R8325 T10845 T10845 ROOT indicated,indicated
R8326 T10846 T10852 mark that,decreased
R8327 T10847 T10849 amod total,levels
R8328 T10848 T10849 amod FoxO1,levels
R8329 T10849 T10852 nsubjpass levels,decreased
R8330 T10850 T10852 auxpass were,decreased
R8331 T10851 T10852 advmod greatly,decreased
R8332 T10852 T10845 ccomp decreased,indicated
R8333 T10853 T10852 prep in,decreased
R8334 T10854 T10858 nmod wild-type,lymphomas
R8335 T10855 T10854 cc and,wild-type
R8336 T10856 T10854 conj LMP1,wild-type
R8337 T10857 T10858 amod transgenic,lymphomas
R8338 T10858 T10853 pobj lymphomas,in
R8339 T10859 T10861 punct (,6B
R8340 T10860 T10861 compound Figure,6B
R8341 T10861 T10858 appos 6B,lymphomas
R8342 T10862 T10858 punct ),lymphomas
R8343 T10863 T10852 punct ",",decreased
R8344 T10864 T10852 advcl suggesting,decreased
R8345 T10865 T10872 mark that,is
R8346 T10866 T10872 nsubj inhibition,is
R8347 T10867 T10866 prep of,inhibition
R8348 T10868 T10869 det the,Forkhead
R8349 T10869 T10867 pobj Forkhead,of
R8350 T10870 T10872 csubj signaling,is
R8392 T10912 T10902 conj be,be
R8393 T10913 T10914 det that,progression
R8394 T10914 T10912 attr progression,be
R8395 T10915 T10916 aux to,lymphoma
R8396 T10916 T10917 nsubj lymphoma,requires
R8397 T10917 T10912 advcl requires,be
R8398 T10918 T10917 dobj modulation,requires
R8399 T10919 T10918 prep of,modulation
R8400 T10920 T10921 amod multiple,pathways
R8401 T10921 T10919 pobj pathways,of
R8402 T10922 T10917 punct .,requires
R8403 T10923 T10925 det The,family
R8404 T10924 T10925 compound Forkhead,family
R8405 T10925 T10930 nsubjpass family,known
R8406 T10926 T10925 prep of,family
R8407 T10927 T10928 compound transcription,factors
R8408 T10928 T10926 pobj factors,of
R8409 T10929 T10930 auxpass is,known
R8410 T10930 T10930 ROOT known,known
R8411 T10931 T10932 aux to,induce
R8412 T10932 T10930 xcomp induce,known
R8413 T10933 T10934 det the,expression
R8414 T10934 T10932 dobj expression,induce
R8415 T10935 T10934 prep of,expression
R8416 T10936 T10938 det the,inhibitor
R8417 T10937 T10938 compound Cdk,inhibitor
R8418 T10938 T10935 pobj inhibitor,of
R8419 T10939 T10942 nummod p27,]
R8420 T10940 T10942 nmod [,]
R8421 T10941 T10942 nummod "43,44",]
R8422 T10942 T10938 appos ],inhibitor
R8423 T10943 T10930 punct .,known
R8424 T10944 T10946 amod LMP1-transformed,fibroblasts
R8425 T10945 T10946 compound rodent,fibroblasts
R8426 T10946 T10948 nsubj fibroblasts,decreased
R8427 T10947 T10948 aux have,decreased
R8428 T10948 T10948 ROOT decreased,decreased
R8429 T10949 T10948 dobj expression,decreased
R8451 T10971 T10948 punct .,decreased
R8452 T10972 T10973 aux To,investigate
R8453 T10973 T10998 advcl investigate,performed
R8454 T10974 T10976 mark whether,affected
R8455 T10975 T10976 nsubj LMP1,affected
R8456 T10976 T10998 advcl affected,performed
R8457 T10977 T10978 compound cell,cycle
R8458 T10978 T10979 compound cycle,regulation
R8459 T10979 T10976 dobj regulation,affected
R8460 T10980 T10976 prep through,affected
R8461 T10981 T10983 det the,pathway
R8462 T10982 T10983 compound Rb,pathway
R8463 T10983 T10980 pobj pathway,through
R8464 T10984 T10983 prep in,pathway
R8465 T10985 T10986 compound B,cells
R8466 T10986 T10984 pobj cells,in
R8467 T10987 T10983 punct ",",pathway
R8468 T10988 T10989 compound immunoblot,analyses
R8469 T10989 T10976 advcl analyses,affected
R8470 T10990 T10989 prep for,analyses
R8471 T10991 T10990 pobj pRb,for
R8472 T10992 T10991 punct ",",pRb
R8473 T10993 T10991 conj Cdk2,pRb
R8474 T10994 T10993 punct ",",Cdk2
R8475 T10995 T10989 cc and,analyses
R8476 T10996 T10998 nsubjpass p27,performed
R8477 T10997 T10998 auxpass were,performed
R8478 T10998 T10998 ROOT performed,performed
R8479 T10999 T10998 prep on,performed
R8480 T11000 T11001 compound splenic,CD19
R8481 T11001 T10999 pobj CD19,on
R8482 T11002 T11004 compound +,B
R8483 T11003 T11004 compound MACS-purified,B
R8484 T11004 T11005 compound B,cells
R8485 T11005 T10998 dobj cells,performed
R8486 T11006 T10998 punct .,performed
R8487 T11007 T11010 nummod LMP1,cells
R8488 T11008 T11010 amod transgenic,cells
R8489 T11009 T11010 compound B,cells
R8490 T11010 T11012 nsubj cells,enhanced
R8491 T11011 T11012 aux had,enhanced
R8492 T11012 T11012 ROOT enhanced,enhanced
R8493 T11013 T11012 dobj levels,enhanced
R8494 T11014 T11013 prep of,levels
R8495 T11015 T11014 pobj pRb,of
R8496 T11016 T11013 prep with,levels
R8497 T11017 T11018 amod concomitant,stabilization
R8498 T11018 T11016 pobj stabilization,with
R8499 T11019 T11018 prep of,stabilization
R8500 T11020 T11022 amod total,levels
R8501 T11021 T11022 compound Rb,levels
R8502 T11022 T11019 pobj levels,of
R8503 T11023 T11022 cc and,levels
R8504 T11024 T11022 conj Cdk2,levels
R8505 T11025 T11012 prep compared,enhanced
R8506 T11026 T11025 prep to,compared
R8507 T11027 T11029 amod wild-type,lymphocytes
R8508 T11028 T11029 compound B,lymphocytes
R8509 T11029 T11026 pobj lymphocytes,to
R8510 T11030 T11032 punct (,6C
R8511 T11031 T11032 compound Figure,6C
R8512 T11032 T11029 appos 6C,lymphocytes
R8513 T11033 T11032 punct ),6C
R8514 T11034 T11012 punct .,enhanced
R8515 T11035 T11046 nsubj Progression,led
R8516 T11036 T11037 aux to,lymphoma
R8517 T11037 T11035 xcomp lymphoma,Progression
R8518 T11038 T11037 prep in,lymphoma
R8519 T11039 T11040 preconj both,wild-type
R8520 T11040 T11045 amod wild-type,cells
R8521 T11041 T11040 cc and,wild-type
R8522 T11042 T11040 conj LMP1,wild-type
R8523 T11043 T11045 amod transgenic,cells
R8524 T11044 T11045 compound lymphoma,cells
R8525 T11045 T11038 pobj cells,in
R8526 T11046 T11046 ROOT led,led
R8527 T11047 T11046 prep to,led
R8528 T11048 T11049 amod increased,levels
R8529 T11049 T11047 pobj levels,to
R8530 T11050 T11049 prep of,levels
R8531 T11051 T11050 pobj Rb,of
R8532 T11052 T11049 punct ",",levels
R8533 T11053 T11054 advmod correspondingly,high
R8534 T11054 T11055 amod high,levels
R8535 T11055 T11049 conj levels,levels
R8536 T11056 T11055 prep of,levels
R8537 T11057 T11056 pobj Cdk2,of
R8538 T11058 T11055 punct ",",levels
R8539 T11059 T11055 cc and,levels
R8540 T11060 T11061 amod decreased,levels
R8541 T11061 T11055 conj levels,levels
R8542 T11062 T11061 prep of,levels
R8543 T11063 T11062 pobj p27,of
R8544 T11064 T11066 punct (,6C
R8545 T11065 T11066 compound Figure,6C
R8546 T11066 T11061 appos 6C,levels
R8547 T11067 T11066 punct ),6C
R8548 T11068 T11046 punct .,led
R8549 T11069 T11070 det These,data
R8550 T11070 T11071 nsubj data,indicate
R8551 T11071 T11071 ROOT indicate,indicate
R8552 T11072 T11077 mark that,deregulated
R8553 T11073 T11075 det the,pathway
R8554 T11074 T11075 compound Rb,pathway
R8555 T11075 T11077 nsubjpass pathway,deregulated
R8556 T11076 T11077 auxpass is,deregulated
R8557 T11077 T11071 ccomp deregulated,indicate
R8558 T11078 T11077 prep in,deregulated
R8559 T11079 T11081 nummod LMP1,lymphocytes
R8560 T11080 T11081 amod transgenic,lymphocytes
R8561 T11081 T11078 pobj lymphocytes,in
R8562 T11082 T11077 cc and,deregulated
R8563 T11083 T11087 mark that,distinguished
R8564 T11084 T11085 compound lymphoma,cells
R8565 T11085 T11087 nsubjpass cells,distinguished
R8566 T11086 T11087 auxpass are,distinguished
R8567 T11087 T11077 conj distinguished,deregulated
R8568 T11088 T11087 agent by,distinguished
R8569 T11089 T11088 pobj loss,by
R8570 T11090 T11089 prep of,loss
R8571 T11091 T11090 pobj FoxO1,of
R8572 T11092 T11087 cc and,distinguished
R8573 T11093 T11087 conj decreased,distinguished
R8574 T11094 T11093 dobj p27,decreased
R8575 T11095 T11071 punct .,indicate
R12296 T16112 T16113 det This,study
R12297 T16113 T16114 nsubj study,defines
R12298 T16114 T16114 ROOT defines,defines
R12299 T16115 T16117 det the,properties
R12300 T16116 T16117 amod oncogenic,properties
R12301 T16117 T16114 dobj properties,defines
R12302 T16118 T16117 prep of,properties
R12303 T16119 T16118 pobj LMP1,of
R12304 T16120 T16114 prep in,defines
R12305 T16121 T16120 pcomp promoting,in
R12306 T16122 T16123 compound B,cell
R12307 T16123 T16124 compound cell,lymphomagenesis
R12308 T16124 T16121 dobj lymphomagenesis,promoting
R12309 T16125 T16114 punct .,defines
R12310 T16126 T16128 nummod LMP1,mice
R12311 T16127 T16128 amod transgenic,mice
R12312 T16128 T16129 nsubj mice,have
R12313 T16129 T16129 ROOT have,have
R12314 T16130 T16132 det a,incidence
R12315 T16131 T16132 amod higher,incidence
R12316 T16132 T16129 dobj incidence,have
R12317 T16133 T16132 prep of,incidence
R12318 T16134 T16133 pobj lymphoma,of
R12319 T16135 T16132 appos [,incidence
R12320 T16136 T16137 nummod 26,]
R12321 T16137 T16135 appos ],[
R12322 T16138 T16137 cc and,]
R12323 T16139 T16140 det the,progression
R12324 T16140 T16137 conj progression,]
R12325 T16141 T16142 aux to,lymphoma
R12326 T16142 T16140 relcl lymphoma,progression
R12327 T16143 T16142 dobj correlates,lymphoma
R12328 T16144 T16143 prep with,correlates
R12329 T16145 T16147 amod higher,levels
R12330 T16146 T16147 compound expression,levels
R12331 T16147 T16144 pobj levels,with
R12332 T16148 T16147 prep of,levels
R12333 T16149 T16148 pobj LMP1,of
R12334 T16150 T16152 punct (,1A
R12335 T16151 T16152 compound Figure,1A
R12336 T16152 T16149 appos 1A,LMP1
R12337 T16153 T16152 cc and,1A
R12338 T16154 T16152 conj 1B,1A
R12339 T16155 T16152 punct ),1A
R12340 T16156 T16129 punct ",",have
R12341 T16157 T16129 advcl suggesting,have
R12342 T16158 T16162 mark that,involved
R12343 T16159 T16162 nsubjpass LMP1,involved
R12344 T16160 T16162 auxpass is,involved
R12345 T16161 T16162 advmod directly,involved
R12346 T16162 T16157 ccomp involved,suggesting
R12347 T16163 T16162 prep in,involved
R12348 T16164 T16165 compound tumor,development
R12349 T16165 T16163 pobj development,in
R12350 T16166 T16129 punct .,have
R12351 T16167 T16169 nsubj Table,summarizes
R12352 T16168 T16167 nummod 1,Table
R12353 T16169 T16169 ROOT summarizes,summarizes
R12354 T16170 T16174 det the,properties
R12355 T16171 T16174 amod biological,properties
R12356 T16172 T16171 cc and,biological
R12357 T16173 T16171 conj molecular,biological
R12358 T16174 T16169 dobj properties,summarizes
R12359 T16175 T16177 nsubjpass that,identified
R12360 T16176 T16177 auxpass were,identified
R12361 T16177 T16174 relcl identified,properties
R12362 T16178 T16177 prep in,identified
R12363 T16179 T16183 amod wild-type,lymphomas
R12364 T16180 T16179 cc and,wild-type
R12365 T16181 T16179 conj LMP1,wild-type
R12366 T16182 T16183 amod transgenic,lymphomas
R12367 T16183 T16178 pobj lymphomas,in
R12368 T16184 T16169 punct .,summarizes
R12369 T16185 T16191 mark Although,studied
R12370 T16186 T16191 nsubj many,studied
R12371 T16187 T16186 prep of,many
R12372 T16188 T16190 det the,properties
R12373 T16189 T16190 amod molecular,properties
R12374 T16190 T16187 pobj properties,of
R12375 T16191 T16203 advcl studied,distinguishing
R12376 T16192 T16193 auxpass were,similar
R12377 T16193 T16191 advmod similar,studied
R12378 T16194 T16193 prep between,similar
R12379 T16195 T16199 nmod wild-type,lymphomas
R12380 T16196 T16195 cc and,wild-type
R12381 T16197 T16195 conj LMP1,wild-type
R12382 T16198 T16199 amod transgenic,lymphomas
R12383 T16199 T16194 pobj lymphomas,between
R12384 T16200 T16203 punct ",",distinguishing
R12385 T16201 T16203 expl there,distinguishing
R12386 T16202 T16203 aux were,distinguishing
R12387 T16203 T16203 ROOT distinguishing,distinguishing
R12388 T16204 T16205 amod biological,properties
R12389 T16205 T16203 dobj properties,distinguishing
R12390 T16206 T16205 punct ",",properties
R12391 T16207 T16209 advmod namely,ability
R12392 T16208 T16209 det the,ability
R12393 T16209 T16205 appos ability,properties
R12394 T16210 T16209 prep of,ability
R12395 T16211 T16213 nummod LMP1,lymphomas
R12396 T16212 T16213 amod transgenic,lymphomas
R12397 T16213 T16210 pobj lymphomas,of
R12398 T16214 T16215 aux to,induce
R12399 T16215 T16209 acl induce,ability
R12400 T16216 T16217 amod higher,levels
R12401 T16217 T16215 dobj levels,induce
R12402 T16218 T16217 prep of,levels
R12403 T16219 T16218 pobj survival,of
R12404 T16220 T16219 cc and,survival
R12405 T16221 T16219 conj proliferation,survival
R12406 T16222 T16203 punct .,distinguishing
R12407 T16223 T16253 advmod Interestingly,explain
R12408 T16224 T16253 punct ",",explain
R12409 T16225 T16229 mark although,develop
R12410 T16226 T16228 amod LMP1,mice
R12411 T16227 T16228 amod transgenic,mice
R12412 T16228 T16229 nsubj mice,develop
R12413 T16229 T16253 advcl develop,explain
R12414 T16230 T16229 dobj lymphomas,develop
R12415 T16231 T16229 prep in,develop
R12416 T16232 T16236 det the,type
R12417 T16233 T16236 amod same,type
R12418 T16234 T16236 compound B-1a,type
R12419 T16235 T16236 compound cell,type
R12420 T16236 T16231 pobj type,in
R12421 T16237 T16253 prep as,explain
R12422 T16238 T16240 amod spontaneous,lymphomas
R12423 T16239 T16240 amod wild-type,lymphomas
R12424 T16240 T16237 pobj lymphomas,as
R12425 T16241 T16242 punct (,Figure
R12426 T16242 T16240 parataxis Figure,lymphomas
R12427 T16243 T16242 nummod 2,Figure
R12428 T16244 T16242 punct ),Figure
R12429 T16245 T16253 punct ",",explain
R12430 T16246 T16248 det some,effects
R12431 T16247 T16248 amod signaling,effects
R12432 T16248 T16253 nsubj effects,explain
R12433 T16249 T16248 acl induced,effects
R12434 T16250 T16249 agent by,induced
R12435 T16251 T16250 pobj LMP1,by
R12436 T16252 T16253 aux may,explain
R12437 T16253 T16253 ROOT explain,explain
R12438 T16254 T16256 det the,promotion
R12439 T16255 T16256 amod enhanced,promotion
R12440 T16256 T16253 dobj promotion,explain
R12441 T16257 T16258 aux to,lymphomagenesis
R12442 T16258 T16256 relcl lymphomagenesis,promotion
R12443 T16259 T16253 punct .,explain
R12444 T16260 T16264 prep Since,decreased
R12445 T16261 T16262 amod CD40-deficient,mice
R12446 T16262 T16264 nsubj mice,decreased
R12447 T16263 T16264 aux have,decreased
R12448 T16264 T16293 advcl decreased,contribute
R12449 T16265 T16264 dobj numbers,decreased
R12450 T16266 T16265 prep of,numbers
R12451 T16267 T16268 compound IgMhighIgDlow,cells
R12452 T16268 T16266 pobj cells,of
R12466 T16282 T16277 conj cells,zone
R12491 T16307 T16316 mark that,shown
R12492 T16308 T16316 nsubjpass expression,shown
R12493 T16309 T16308 prep of,expression
R12494 T16310 T16309 pobj LMP1,of
R12495 T16311 T16310 prep in,LMP1
R12496 T16312 T16313 amod transgenic,mice
R12555 T16371 T16372 det the,absence
R12556 T16372 T16370 pobj absence,in
R12557 T16373 T16372 prep of,absence
R12558 T16374 T16373 pobj transformation,of
R12559 T16375 T16369 punct .,occurs
R12560 T16376 T16377 det These,results
R12561 T16377 T16378 nsubj results,suggest
R12562 T16378 T16378 ROOT suggest,suggest
R12563 T16379 T16389 mark that,promotes
R12564 T16380 T16381 det the,mimicry
R12565 T16381 T16389 nsubj mimicry,promotes
R12566 T16382 T16381 prep of,mimicry
R12567 T16383 T16385 compound B,receptor
R12568 T16384 T16385 compound cell,receptor
R12569 T16385 T16382 pobj receptor,of
R12570 T16386 T16381 acl signaling,mimicry
R12571 T16387 T16386 prep by,signaling
R12572 T16388 T16387 pobj LMP2,by
R12573 T16389 T16378 ccomp promotes,suggest
R12574 T16390 T16392 amod B-1,differentiation
R12575 T16391 T16392 compound cell,differentiation
R12576 T16392 T16389 dobj differentiation,promotes
R12577 T16393 T16392 cc but,differentiation
R12578 T16394 T16395 neg not,transformation
R12579 T16395 T16392 conj transformation,differentiation
R12580 T16396 T16398 compound [,]
R12581 T16397 T16398 compound "24,50,51",]
R12582 T16398 T16395 appos ],transformation
R12583 T16399 T16378 punct .,suggest
R12584 T16400 T16401 det This,promotion
R12585 T16401 T16406 nsubj promotion,account
R12586 T16402 T16401 prep of,promotion
R12587 T16403 T16404 compound B-1,differentiation
R12588 T16404 T16402 pobj differentiation,of
R12589 T16405 T16406 aux may,account
R12590 T16406 T16406 ROOT account,account
R12591 T16407 T16406 prep for,account
R12592 T16408 T16409 det the,ability
R12593 T16409 T16407 pobj ability,for
R12594 T16410 T16409 prep of,ability
R12595 T16411 T16410 pobj LMP2,of
R12596 T16412 T16413 aux to,exacerbate
R12597 T16413 T16409 acl exacerbate,ability
R12598 T16414 T16413 dobj autoimmunity,exacerbate
R12599 T16415 T16414 cc and,autoimmunity
R12600 T16416 T16418 nmod bypass,induction
R12601 T16417 T16418 compound anergy,induction
R12602 T16418 T16414 conj induction,autoimmunity
R12603 T16419 T16421 compound [,]
R12604 T16420 T16421 compound "52,53",]
R12605 T16421 T16418 dobj ],induction
R12606 T16422 T16406 punct .,account
R12607 T16423 T16435 prep In,reflect
R12608 T16424 T16423 pobj contrast,In
R12609 T16425 T16435 punct ",",reflect
R12610 T16426 T16427 det the,preponderance
R12611 T16427 T16435 nsubj preponderance,reflect
R12612 T16428 T16427 prep of,preponderance
R12613 T16429 T16428 pobj tumors,of
R12614 T16430 T16429 prep of,tumors
R12615 T16431 T16432 amod B-1a,origin
R12616 T16432 T16430 pobj origin,of
R12617 T16433 T16435 aux does,reflect
R12618 T16434 T16435 neg not,reflect
R12619 T16435 T16435 ROOT reflect,reflect
R12620 T16436 T16454 nsubj effects,contain
R12621 T16437 T16436 prep of,effects
R12622 T16438 T16437 pobj LMP1,of
R12623 T16439 T16436 acl signaling,effects
R12624 T16440 T16439 prep on,signaling
R12625 T16441 T16443 compound B,differentiation
R12626 T16442 T16443 compound cell,differentiation
R12627 T16443 T16440 pobj differentiation,on
R12628 T16444 T16439 punct ",",signaling
R12629 T16445 T16436 prep as,effects
R12630 T16446 T16448 amod splenic,cells
R12631 T16447 T16448 compound B,cells
R12632 T16448 T16445 pobj cells,as
R12633 T16449 T16436 prep from,effects
R12634 T16450 T16453 amod healthy,mice
R12635 T16451 T16453 compound LMP1,mice
R12636 T16452 T16453 compound transgenic,mice
R12637 T16453 T16449 pobj mice,from
R12638 T16454 T16435 ccomp contain,reflect
R12639 T16455 T16456 amod similar,numbers
R12640 T16456 T16454 dobj numbers,contain
R12641 T16457 T16456 prep of,numbers
R12642 T16458 T16461 amod B-1,cells
R12643 T16459 T16458 cc and,B-1
R12644 T16460 T16458 conj B-2,B-1
R12645 T16461 T16457 pobj cells,of
R12646 T16462 T16454 prep as,contain
R12647 T16463 T16464 amod wild-type,mice
R12648 T16464 T16462 pobj mice,as
R12649 T16465 T16435 punct .,reflect
R12650 T16466 T16482 prep In,thought
R12651 T16467 T16466 pobj support,In
R12652 T16468 T16467 prep of,support
R12653 T16469 T16470 det this,lack
R12654 T16470 T16468 pobj lack,of
R12655 T16471 T16470 prep of,lack
R12656 T16472 T16471 pobj effect,of
R12657 T16473 T16482 punct ",",thought
R12658 T16474 T16475 det the,differentiation
R12659 T16475 T16482 nsubjpass differentiation,thought
R12660 T16476 T16475 prep of,differentiation
R12661 T16477 T16480 nmod B-1,cells
R12662 T16478 T16477 cc versus,B-1
R12663 T16479 T16477 conj B-2,B-1
R12664 T16480 T16476 pobj cells,of
R12665 T16481 T16482 auxpass is,thought
R12666 T16482 T16482 ROOT thought,thought
R12667 T16483 T16484 aux to,be
R12668 T16484 T16482 xcomp be,thought
R12669 T16485 T16484 acomp independent,be
R12670 T16486 T16485 prep of,independent
R12671 T16487 T16488 meta CD40,signaling
R12672 T16488 T16482 advcl signaling,thought
R12673 T16489 T16491 nmod [,]
R12674 T16490 T16491 nummod 54,]
R12675 T16491 T16488 dobj ],signaling
R12676 T16492 T16482 punct .,thought
R12677 T16493 T16494 compound B-1,cells
R12678 T16494 T16495 nsubj cells,constitute
R12679 T16495 T16495 ROOT constitute,constitute
R12680 T16496 T16499 det the,population
R12681 T16497 T16499 amod predominant,population
R12682 T16498 T16499 amod lymphocyte,population
R12683 T16499 T16495 dobj population,constitute
R12684 T16500 T16499 prep in,population
R12685 T16501 T16505 det the,cavities
R12686 T16502 T16505 amod peritoneal,cavities
R12687 T16503 T16502 cc and,peritoneal
R12688 T16504 T16502 conj pleuropericardial,peritoneal
R12689 T16505 T16500 pobj cavities,in
R12690 T16506 T16495 punct ",",constitute
R12691 T16507 T16512 mark while,found
R12692 T16508 T16509 compound B-2,cells
R12693 T16509 T16512 nsubjpass cells,found
R12694 T16510 T16512 auxpass are,found
R12695 T16511 T16512 advmod mainly,found
R12696 T16512 T16495 advcl found,constitute
R12697 T16513 T16512 prep in,found
R12698 T16514 T16515 det the,spleen
R12699 T16515 T16513 pobj spleen,in
R12700 T16516 T16512 punct ",",found
R12701 T16517 T16518 amod lymph,node
R12702 T16518 T16512 prep node,found
R12703 T16519 T16518 punct ",",node
R12704 T16520 T16518 cc and,node
R12705 T16521 T16522 amod peripheral,blood
R12706 T16522 T16518 conj blood,node
R12707 T16523 T16495 punct .,constitute
R12708 T16524 T16525 amod B-1,cells
R12709 T16525 T16526 nsubj cells,produce
R12710 T16526 T16526 ROOT produce,produce
R12711 T16527 T16529 det the,source
R12712 T16528 T16529 amod main,source
R12713 T16529 T16526 dobj source,produce
R12714 T16530 T16529 prep of,source
R12715 T16531 T16530 pobj IgM,of
R12716 T16532 T16531 cc and,IgM
R12717 T16533 T16531 conj IgA,IgM
R12718 T16534 T16529 conj antibodies,source
R12719 T16535 T16529 prep in,source
R12720 T16536 T16535 pobj serum,in
R12721 T16537 T16536 punct ",",serum
R12722 T16538 T16540 nsubjpass which,involved
R12723 T16539 T16540 auxpass are,involved
R12724 T16540 T16529 relcl involved,source
R12725 T16541 T16540 prep in,involved
R12726 T16542 T16543 compound T,cell
R12727 T16543 T16541 pobj cell,in
R12728 T16544 T16545 amod independent,responses
R12729 T16545 T16529 appos responses,source
R12730 T16546 T16545 prep to,responses
R12731 T16547 T16549 amod common,antigens
R12732 T16548 T16549 amod microbial,antigens
R12733 T16549 T16546 pobj antigens,to
R12734 T16550 T16526 punct .,produce
R12735 T16551 T16555 advmod Importantly,have
R12736 T16552 T16555 punct ",",have
R12737 T16553 T16554 amod B-1,cells
R12738 T16554 T16555 nsubj cells,have
R12739 T16555 T16555 ROOT have,have
R12740 T16556 T16558 det the,capacity
R12741 T16557 T16558 amod unique,capacity
R12742 T16558 T16555 dobj capacity,have
R12743 T16559 T16561 aux to,replenish
R12744 T16560 T16561 dep self,replenish
R12745 T16561 T16558 acl replenish,capacity
R12746 T16562 T16561 cc and,replenish
R12747 T16563 T16561 conj are,replenish
R12748 T16564 T16565 advmod also,predisposed
R12749 T16565 T16563 acomp predisposed,are
R12769 T16585 T16583 pobj mo,above
R12770 T16586 T16585 prep of,mo
R12771 T16587 T16586 pobj age,of
R12772 T16588 T16585 punct ",",mo
R12773 T16589 T16585 cc and,mo
R12774 T16590 T16591 amod B-1,cells
R12775 T16591 T16593 nsubjpass cells,thought
R12776 T16592 T16593 auxpass are,thought
R12777 T16593 T16579 conj thought,detected
R12778 T16594 T16595 aux to,be
R12779 T16595 T16593 xcomp be,thought
R12780 T16596 T16598 det the,progenitor
R12781 T16597 T16598 compound murine,progenitor
R12782 T16598 T16595 attr progenitor,be
R12783 T16599 T16598 prep of,progenitor
R12784 T16600 T16604 compound B,leukemia
R12785 T16601 T16602 compound cell,chronic
R12786 T16602 T16604 amod chronic,leukemia
R12787 T16603 T16604 compound lymphocytic,leukemia
R12788 T16604 T16599 pobj leukemia,of
R12789 T16605 T16604 appos [,leukemia
R12790 T16606 T16605 nummod 30,[
R12791 T16607 T16604 appos ],leukemia
R12792 T16608 T16593 punct .,thought
R12793 T16609 T16610 det The,data
R12794 T16610 T16615 nsubj data,indicate
R12795 T16611 T16610 acl presented,data
R12796 T16612 T16611 prep in,presented
R12797 T16613 T16614 det this,study
R12798 T16614 T16612 pobj study,in
R12799 T16615 T16615 ROOT indicate,indicate
R12800 T16616 T16631 mark that,develops
R12801 T16617 T16620 mark although,expressed
R12802 T16618 T16620 nsubjpass LMP1,expressed
R12803 T16619 T16620 auxpass is,expressed
R12804 T16620 T16631 advcl expressed,develops
R12805 T16621 T16620 prep in,expressed
R12806 T16622 T16624 det all,lymphocytes
R12807 T16623 T16624 compound B,lymphocytes
R12808 T16624 T16621 pobj lymphocytes,in
R12809 T16625 T16620 prep in,expressed
R12810 T16626 T16628 det the,mice
R12811 T16627 T16628 amod transgenic,mice
R12812 T16628 T16625 pobj mice,in
R12813 T16629 T16631 punct ",",develops
R12814 T16630 T16631 nsubj malignancy,develops
R12815 T16631 T16615 ccomp develops,indicate
R12816 T16632 T16631 prep in,develops
R12817 T16633 T16635 det this,subset
R12818 T16634 T16635 amod specific,subset
R12819 T16635 T16632 pobj subset,in
R12820 T16636 T16635 prep of,subset
R12821 T16637 T16638 compound B,cells
R12822 T16638 T16636 pobj cells,of
R12823 T16639 T16615 punct .,indicate
R12824 T16640 T16642 det The,expression
R12825 T16641 T16642 amod elevated,expression
R12826 T16642 T16655 nsubj expression,induce
R12827 T16643 T16642 prep of,expression
R12828 T16644 T16643 pobj LMP1,of
R12829 T16645 T16644 prep in,LMP1
R12830 T16646 T16647 amod B-1a,cells
R12831 T16647 T16645 pobj cells,in
R12832 T16648 T16642 cc and,expression
R12833 T16649 T16650 det the,activation
R12834 T16650 T16642 conj activation,expression
R12835 T16651 T16650 prep of,activation
R12836 T16652 T16653 amod specific,pathways
R12837 T16653 T16651 pobj pathways,of
R12838 T16654 T16655 advmod apparently,induce
R12839 T16655 T16655 ROOT induce,induce
R12840 T16656 T16657 compound malignant,growth
R12841 T16657 T16655 dobj growth,induce
R12842 T16658 T16655 punct .,induce
R12843 T16659 T16661 det These,pathways
R12844 T16660 T16661 amod same,pathways
R12845 T16661 T16664 nsubj pathways,become
R12846 T16662 T16664 aux can,become
R12847 T16663 T16664 advmod also,become
R12848 T16664 T16664 ROOT become,become
R12849 T16665 T16666 advmod sporadically,activated
R12850 T16666 T16664 acomp activated,become
R12851 T16667 T16666 prep in,activated
R12852 T16668 T16669 amod aged,mice
R12853 T16669 T16667 pobj mice,in
R12854 T16670 T16666 cc and,activated
R12855 T16671 T16672 advmod also,result
R12856 T16672 T16664 conj result,become
R12857 T16673 T16672 prep in,result
R12858 T16674 T16675 compound lymphoma,development
R12859 T16675 T16673 pobj development,in
R12860 T16676 T16664 punct .,become
R12861 T16677 T16678 nsubj This,is
R12862 T16678 T16678 ROOT is,is
R12863 T16679 T16678 acomp similar,is
R12864 T16680 T16679 prep to,similar
R12865 T16681 T16682 amod EBV-associated,cancers
R12866 T16682 T16680 pobj cancers,to
R12867 T16683 T16682 prep in,cancers
R12868 T16684 T16683 pobj vivo,in
R12869 T16685 T16684 punct ",",vivo
R12870 T16686 T16695 advmod where,activated
R12871 T16687 T16695 nsubjpass pathways,activated
R12872 T16688 T16690 nsubjpass that,activated
R12873 T16689 T16690 auxpass are,activated
R12874 T16690 T16687 relcl activated,pathways
R12875 T16691 T16690 agent by,activated
R12876 T16692 T16691 pobj LMP1,by
R12877 T16693 T16695 auxpass are,activated
R12878 T16694 T16695 advmod also,activated
R12879 T16695 T16682 relcl activated,cancers
R12880 T16696 T16695 prep in,activated
R12881 T16697 T16701 det the,forms
R12882 T16698 T16699 advmod less,prevalent
R12883 T16699 T16701 amod prevalent,forms
R12884 T16700 T16701 amod EBV-negative,forms
R12885 T16701 T16696 pobj forms,in
R12886 T16702 T16701 prep of,forms
R12887 T16703 T16704 det the,cancers
R12888 T16704 T16702 pobj cancers,of
R12889 T16741 T16743 nsubjpass lymphomas,marked
R12890 T16705 T16706 compound [,"40,55"
R12891 T16742 T16743 auxpass were,marked
R12892 T16743 T16743 ROOT marked,marked
R12893 T16744 T16743 agent by,marked
R12894 T16706 T16701 appos "40,55",forms
R12895 T16745 T16746 det the,upregulation
R12896 T16746 T16744 pobj upregulation,by
R12897 T16747 T16746 prep of,upregulation
R12898 T16707 T16708 nummod 58,]
R12899 T16748 T16747 pobj IL10,of
R12900 T16749 T16748 punct ",",IL10
R12901 T16708 T16701 appos ],forms
R12902 T16750 T16751 amod constitutive,activation
R12903 T16751 T16748 appos activation,IL10
R12904 T16709 T16678 punct .,is
R12905 T16752 T16751 prep of,activation
R12906 T16753 T16754 amod Stat3,signaling
R12907 T16754 T16752 pobj signaling,of
R12908 T16710 T16721 advmod Thus,is
R12909 T16755 T16743 punct ",",marked
R12910 T16756 T16743 cc and,marked
R12911 T16757 T16758 det a,requirement
R12912 T16758 T16743 conj requirement,marked
R12913 T16711 T16721 punct ",",is
R12914 T16759 T16758 prep for,requirement
R12915 T16760 T16759 pobj activation,for
R12916 T16712 T16713 det the,contribution
R12917 T16761 T16760 prep of,activation
R12918 T16762 T16761 pobj Akt,of
R12919 T16713 T16721 nsubj contribution,is
R12920 T16763 T16762 punct ",",Akt
R12921 T16764 T16762 conj NFκB,Akt
R12922 T16765 T16764 punct ",",NFκB
R12923 T16714 T16713 prep of,contribution
R12924 T16766 T16764 cc and,NFκB
R12925 T16767 T16768 amod Stat3,pathways
R12926 T16768 T16764 conj pathways,NFκB
R12927 T16715 T16714 pobj EBV,of
R12928 T16769 T16770 punct (,Figures
R12929 T16770 T16768 parataxis Figures,pathways
R12930 T16771 T16770 nummod 5,Figures
R12931 T16772 T16771 cc and,5
R12932 T16716 T16715 cc and,EBV
R12933 T16773 T16771 conj 7,5
R12934 T16774 T16770 punct ),Figures
R12935 T16775 T16743 punct .,marked
R12936 T16776 T16780 nsubjpass Induction,associated
R12937 T16717 T16715 conj LMP1,EBV
R12938 T16777 T16776 prep of,Induction
R12939 T16778 T16777 pobj IL10,of
R12940 T16779 T16780 auxpass is,associated
R12941 T16718 T16713 prep to,contribution
R12942 T16780 T16780 ROOT associated,associated
R12943 T16781 T16780 prep with,associated
R12944 T16782 T16783 det the,transformation
R12945 T16783 T16781 pobj transformation,with
R12946 T16784 T16783 prep of,transformation
R12947 T16785 T16786 compound B-1,lymphomas
R12948 T16719 T16720 compound tumor,development
R12949 T16786 T16784 pobj lymphomas,of
R12950 T16787 T16783 prep in,transformation
R12951 T16788 T16787 pobj mice,in
R12952 T16720 T16718 pobj development,to
R12953 T16789 T16791 compound [,]
R12954 T16790 T16791 compound "59,60",]
R12955 T16721 T16721 ROOT is,is
R12956 T16791 T16783 appos ],transformation
R12957 T16792 T16780 cc and,associated
R12958 T16793 T16795 auxpass is,associated
R12959 T16794 T16795 advmod frequently,associated
R12960 T16722 T16721 advmod apparently,is
R12961 T16795 T16780 conj associated,associated
R12962 T16796 T16795 prep with,associated
R12963 T16797 T16800 amod EBV-positive,malignancies
R12964 T16723 T16725 det the,activation
R12965 T16798 T16799 compound B,cell
R12966 T16799 T16800 compound cell,malignancies
R12967 T16800 T16796 pobj malignancies,with
R12968 T16724 T16725 amod continuous,activation
R12969 T16801 T16795 advcl acting,associated
R12970 T16802 T16801 prep as,acting
R12971 T16803 T16807 det a,factor
R12972 T16725 T16721 attr activation,is
R12973 T16804 T16805 compound B,cell
R12974 T16805 T16806 compound cell,growth
R12975 T16806 T16807 compound growth,factor
R12976 T16726 T16725 prep of,activation
R12977 T16807 T16802 pobj factor,as
R12978 T16727 T16726 pobj pathways,of
R12979 T16808 T16807 appos [,factor
R12980 T16809 T16808 nummod 35,[
R12981 T16810 T16811 nummod 38,]
R12982 T16811 T16808 appos ],[
R12983 T16728 T16733 nsubjpass that,activated
R12984 T16812 T16780 punct .,associated
R12985 T16813 T16819 prep In,shown
R12986 T16814 T16813 pobj addition,In
R12987 T16729 T16733 aux can,activated
R12988 T16815 T16819 punct ",",shown
R12989 T16730 T16733 advmod also,activated
R12990 T16816 T16819 nsubjpass LMP1,shown
R12991 T16731 T16733 auxpass be,activated
R12992 T16817 T16819 aux has,shown
R12993 T16818 T16819 auxpass been,shown
R12994 T16819 T16819 ROOT shown,shown
R12995 T16820 T16821 aux to,stimulate
R12996 T16821 T16819 xcomp stimulate,shown
R12997 T16822 T16823 compound IL10,expression
R12998 T16732 T16733 advmod sporadically,activated
R12999 T16823 T16821 dobj expression,stimulate
R13000 T16824 T16821 prep in,stimulate
R13001 T16733 T16727 relcl activated,pathways
R13002 T16825 T16828 compound Burkitt,lines
R13003 T16826 T16827 compound lymphoma,cell
R13004 T16827 T16828 compound cell,lines
R13005 T16734 T16733 cc and,activated
R13006 T16828 T16824 pobj lines,in
R13007 T16829 T16831 compound [,]
R13008 T16830 T16831 compound "61,62",]
R13009 T16735 T16721 conj contribute,is
R13010 T16831 T16828 appos ],lines
R13011 T16832 T16819 punct .,shown
R13012 T16833 T16834 nsubj This,suggests
R13013 T16736 T16735 prep to,contribute
R13014 T16834 T16834 ROOT suggests,suggests
R13015 T16835 T16852 mark that,enhance
R13016 T16836 T16840 mark although,activated
R13017 T16737 T16738 compound tumor,development
R13018 T16837 T16840 nsubjpass Stat3,activated
R13019 T16738 T16736 pobj development,to
R13020 T16739 T16721 punct .,is
R13021 T16740 T16741 det The,lymphomas
R13022 T16838 T16840 auxpass is,activated
R13023 T16935 T16938 nsubj We,shown
R13024 T16839 T16840 advmod constitutively,activated
R13025 T16840 T16852 advcl activated,enhance
R13026 T16841 T16840 prep in,activated
R13027 T16842 T16844 det the,cells
R13028 T16936 T16938 aux have,shown
R13029 T16843 T16844 compound lymphoma,cells
R13030 T16844 T16841 pobj cells,in
R13031 T16845 T16852 punct ",",enhance
R13032 T16937 T16938 advmod previously,shown
R13033 T16846 T16847 det the,induction
R13034 T16847 T16852 nsubj induction,enhance
R13035 T16938 T16938 ROOT shown,shown
R13036 T16848 T16847 prep of,induction
R13037 T16849 T16848 pobj IL10,of
R13038 T16850 T16852 aux may,enhance
R13039 T16851 T16852 advmod further,enhance
R13040 T16939 T16943 mark that,activated
R13041 T16852 T16834 ccomp enhance,suggests
R13042 T16853 T16854 amod Stat3,activation
R13043 T16854 T16852 dobj activation,enhance
R13044 T16855 T16852 cc or,enhance
R13045 T16856 T16857 aux may,contribute
R13046 T16857 T16852 conj contribute,enhance
R13047 T16940 T16943 nsubjpass cRel,activated
R13048 T16858 T16857 prep to,contribute
R13049 T16859 T16862 amod other,pathways
R13050 T16860 T16862 amod IL10-responsive,pathways
R13051 T16861 T16862 compound signaling,pathways
R13052 T16941 T16943 auxpass is,activated
R13053 T16862 T16858 pobj pathways,to
R13054 T16863 T16834 punct .,suggests
R13055 T16864 T16865 nummod LMP1,activates
R13056 T16942 T16943 advmod specifically,activated
R13057 T16865 T16884 npadvmod activates,blocked
R13058 T16866 T16871 preconj both,pathways
R13059 T16943 T16938 ccomp activated,shown
R13060 T16944 T16943 prep in,activated
R13061 T16867 T16871 det the,pathways
R13062 T16945 T16946 preconj both,wild-type
R13063 T16868 T16871 amod canonical,pathways
R13064 T16946 T16950 nmod wild-type,lymphomas
R13065 T16947 T16946 cc and,wild-type
R13066 T16869 T16868 cc and,canonical
R13067 T16948 T16946 conj LMP1,wild-type
R13068 T16870 T16868 conj non-canonical,canonical
R13069 T16949 T16950 amod transgenic,lymphomas
R13070 T16871 T16865 dobj pathways,activates
R13071 T16950 T16944 pobj lymphomas,in
R13072 T16951 T16943 punct ",",activated
R13073 T16872 T16871 prep of,pathways
R13074 T16952 T16943 advcl suggesting,activated
R13075 T16873 T16872 pobj NFκB,of
R13076 T16953 T16958 mark that,associated
R13077 T16874 T16871 acl signaling,pathways
R13078 T16954 T16958 nsubjpass activation,associated
R13079 T16875 T16876 compound [,"14,63"
R13080 T16876 T16874 dobj "14,63",signaling
R13081 T16877 T16878 nummod 65,]
R13082 T16955 T16954 prep of,activation
R13083 T16878 T16884 nsubj ],blocked
R13084 T16879 T16878 punct ",",]
R13085 T16880 T16878 cc and,]
R13086 T16956 T16955 pobj cRel,of
R13087 T16881 T16878 conj inhibition,]
R13088 T16882 T16881 prep of,inhibition
R13089 T16883 T16882 pobj NFκB,of
R13090 T16957 T16958 auxpass is,associated
R13091 T16884 T16884 ROOT blocked,blocked
R13092 T16885 T16886 det the,survival
R13093 T16886 T16884 dobj survival,blocked
R13094 T16887 T16886 prep of,survival
R13095 T16888 T16890 nummod LMP1,lymphocytes
R13096 T16889 T16890 amod transgenic,lymphocytes
R13097 T16958 T16952 ccomp associated,suggesting
R13098 T16890 T16887 pobj lymphocytes,of
R13099 T16891 T16890 cc and,lymphocytes
R13100 T16892 T16890 conj LMP1-positive,lymphocytes
R13101 T16893 T16892 cc and,LMP1-positive
R13102 T16959 T16958 prep with,associated
R13103 T16894 T16895 punct -,negative
R13104 T16895 T16897 amod negative,cells
R13105 T16960 T16961 compound B,cell
R13106 T16896 T16897 compound lymphoma,cells
R13107 T16897 T16892 conj cells,LMP1-positive
R13108 T16898 T16884 punct .,blocked
R13109 T16961 T16962 compound cell,transformation
R13110 T16899 T16903 nsubj NFκB,are
R13111 T16900 T16899 cc and,NFκB
R13112 T16901 T16899 conj PI3K,NFκB
R13113 T16962 T16959 pobj transformation,with
R13114 T16963 T16965 nmod [,]
R13115 T16902 T16899 conj signaling,NFκB
R13116 T16903 T16903 ROOT are,are
R13117 T16964 T16965 nummod 27,]
R13118 T16904 T16903 acomp crucial,are
R13119 T16905 T16904 prep for,crucial
R13120 T16906 T16907 amod CD40-induced,proliferation
R13121 T16965 T16962 appos ],transformation
R13122 T16907 T16905 pobj proliferation,for
R13123 T16908 T16903 punct ",",are
R13124 T16909 T16903 cc and,are
R13125 T16910 T16921 nsubj mice,are
R13126 T16966 T16938 punct .,shown
R13127 T16911 T16910 acl deficient,mice
R13128 T16912 T16911 prep for,deficient
R13129 T16967 T16968 poss Our,observations
R13130 T16913 T16912 pobj cRel,for
R13131 T16914 T16913 cc or,cRel
R13132 T16915 T16918 det the,subunit
R13133 T16968 T16969 nsubj observations,suggest
R13134 T16916 T16918 amod p85,subunit
R13135 T16917 T16918 amod regulatory,subunit
R13136 T16918 T16913 conj subunit,cRel
R13137 T16969 T16969 ROOT suggest,suggest
R13138 T16919 T16918 prep of,subunit
R13139 T16920 T16919 pobj PI3K,of
R13140 T16921 T16903 conj are,are
R13141 T16922 T16921 acomp unresponsive,are
R13142 T16970 T16977 mark that,induces
R13143 T16923 T16922 prep to,unresponsive
R13144 T16924 T16925 amod mitogenic,stimuli
R13145 T16925 T16923 pobj stimuli,to
R13146 T16926 T16925 punct ",",stimuli
R13147 T16927 T16925 prep including,stimuli
R13148 T16971 T16977 advcl similar,induces
R13149 T16928 T16929 compound CD40,ligation
R13150 T16929 T16930 compound ligation,[
R13151 T16930 T16927 pobj [,including
R13152 T16972 T16971 prep to,similar
R13153 T16931 T16930 nummod 66,[
R13154 T16932 T16933 nummod 68,]
R13155 T16933 T16930 appos ],[
R13156 T16934 T16921 punct .,are
R13157 T16973 T16974 amod CD40-induced,proliferation
R13158 T16974 T16972 pobj proliferation,to
R13159 T16975 T16977 punct ",",induces
R13160 T16976 T16977 nsubj LMP1,induces
R13161 T17032 T17024 dobj ],increased
R13162 T16977 T16969 ccomp induces,suggest
R13163 T17033 T17024 punct .,increased
R13164 T17034 T17038 mark Although,shown
R13165 T16978 T16977 dobj proliferation,induces
R13166 T17035 T17038 nsubjpass LMP1,shown
R13167 T17036 T17038 aux has,shown
R13168 T17037 T17038 auxpass been,shown
R13169 T16979 T16977 prep through,induces
R13170 T17038 T17055 advcl shown,is
R13171 T17039 T17040 aux to,deregulate
R13172 T17040 T17038 xcomp deregulate,shown
R13173 T16980 T16981 amod PI3K-mediated,activation
R13174 T17041 T17043 det the,pathway
R13175 T17042 T17043 compound Rb,pathway
R13176 T17043 T17040 dobj pathway,deregulate
R13177 T16981 T16979 pobj activation,through
R13178 T17044 T17043 prep in,pathway
R13179 T17045 T17046 amod epithelial,cells
R13180 T17046 T17044 pobj cells,in
R13181 T16982 T16981 prep of,activation
R13182 T17047 T17049 nmod [,]
R13183 T17048 T17049 nummod 69,]
R13184 T17049 T17043 appos ],pathway
R13185 T16983 T16982 pobj Akt,of
R13186 T17050 T17040 punct ",",deregulate
R13187 T17051 T17040 prep to,deregulate
R13188 T17052 T17053 poss our,knowledge
R13189 T16984 T16983 cc and,Akt
R13190 T17053 T17051 pobj knowledge,to
R13191 T17054 T17055 nsubj this,is
R13192 T16985 T16981 conj activation,activation
R13193 T17055 T17055 ROOT is,is
R13194 T17056 T17058 det the,demonstration
R13195 T17057 T17058 amod first,demonstration
R13196 T17058 T17055 attr demonstration,is
R13197 T17059 T17058 prep of,demonstration
R13198 T16986 T16981 prep of,activation
R13199 T16987 T16988 compound NFκB,components
R13200 T17060 T17061 det this,property
R13201 T17061 T17059 pobj property,of
R13202 T17062 T17058 prep in,demonstration
R13203 T16988 T16986 pobj components,of
R13204 T17063 T17064 compound B,lymphocytes
R13205 T17064 T17062 pobj lymphocytes,in
R13206 T17065 T17055 punct .,is
R13207 T17066 T17067 det The,requirement
R13208 T16989 T16990 amod such,as
R13209 T17067 T17072 nsubjpass requirement,confirmed
R13210 T17068 T17067 prep for,requirement
R13211 T16990 T16988 prep as,components
R13212 T17069 T17070 compound Akt,activation
R13213 T17070 T17068 pobj activation,for
R13214 T16991 T16990 pobj cRel,as
R13215 T17071 T17072 auxpass was,confirmed
R13216 T17072 T17072 ROOT confirmed,confirmed
R13217 T17073 T17072 agent by,confirmed
R13218 T17074 T17076 det the,inhibition
R13219 T16992 T16969 punct .,suggest
R13220 T17075 T17076 amod striking,inhibition
R13221 T17076 T17073 pobj inhibition,by
R13222 T17077 T17076 prep of,inhibition
R13223 T16993 T16995 nsubj CD40,induces
R13224 T17078 T17079 compound lymphoma,viability
R13225 T17079 T17077 pobj viability,of
R13226 T17080 T17072 agent by,confirmed
R13227 T16994 T16995 advmod also,induces
R13228 T17081 T17080 pobj triciribine,by
R13229 T17082 T17081 punct ",",triciribine
R13230 T17083 T17085 det an,inhibitor
R13231 T17084 T17085 compound Akt,inhibitor
R13232 T16995 T16995 ROOT induces,induces
R13233 T17085 T17081 appos inhibitor,triciribine
R13234 T17086 T17072 punct .,confirmed
R13235 T17087 T17094 advmod However,lead
R13236 T16996 T16995 dobj downregulation,induces
R13237 T17088 T17094 punct ",",lead
R13238 T17089 T17091 det the,pAkt
R13239 T17090 T17091 amod activated,pAkt
R13240 T16997 T16996 prep of,downregulation
R13241 T17091 T17094 nsubj pAkt,lead
R13242 T17092 T17094 aux did,lead
R13243 T17093 T17094 neg not,lead
R13244 T16998 T17001 det the,inhibitor
R13245 T17094 T17094 ROOT lead,lead
R13246 T17095 T17094 prep to,lead
R13247 T17096 T17095 pobj phosphorylation,to
R13248 T17097 T17096 cc and,phosphorylation
R13249 T17098 T17096 conj inactivation,phosphorylation
R13250 T17099 T17096 prep of,phosphorylation
R13251 T17100 T17102 det the,target
R13252 T16999 T17000 compound cell,cycle
R13253 T17101 T17102 amod downstream,target
R13254 T17102 T17099 pobj target,of
R13255 T17103 T17102 appos GSK3,target
R13256 T17000 T17001 compound cycle,inhibitor
R13257 T17104 T17106 punct (,6A
R13258 T17105 T17106 compound Figure,6A
R13259 T17106 T17103 appos 6A,GSK3
R13260 T17001 T16997 pobj inhibitor,of
R13261 T17107 T17103 punct ),GSK3
R13262 T17108 T17094 punct .,lead
R13263 T17109 T17110 det This,effect
R13264 T17002 T17001 nummod p27,inhibitor
R13265 T17110 T17114 nsubjpass effect,described
R13266 T17111 T17114 aux has,described
R13267 T17112 T17114 advmod also,described
R13268 T17113 T17114 auxpass been,described
R13269 T17003 T16995 prep through,induces
R13270 T17114 T17114 ROOT described,described
R13271 T17115 T17114 prep in,described
R13272 T17116 T17117 compound EBV-positive,HD
R13273 T17117 T17118 compound HD,biopsies
R13274 T17004 T17006 det a,manner
R13275 T17118 T17115 pobj biopsies,in
R13276 T17119 T17121 nmod [,]
R13277 T17120 T17121 nummod 40,]
R13278 T17005 T17006 amod PI3K-dependent,manner
R13279 T17121 T17118 appos ],biopsies
R13280 T17122 T17114 punct .,described
R13281 T17123 T17134 prep In,affect
R13282 T17006 T17003 pobj manner,through
R13283 T17124 T17123 pobj contrast,In
R13284 T17125 T17134 punct ",",affect
R13285 T17126 T17134 nsubj rapamycin,affect
R13286 T17007 T16995 punct ",",induces
R13287 T17127 T17126 punct ",",rapamycin
R13288 T17128 T17126 conj U0126,rapamycin
R13289 T17008 T16995 cc and,induces
R13290 T17009 T17012 det the,cells
R13291 T17010 T17012 compound LMP1,cells
R13292 T17129 T17128 punct ",",U0126
R13293 T17011 T17012 compound lymphoma,cells
R13294 T17130 T17128 cc and,U0126
R13295 T17131 T17128 conj SB202190,U0126
R13296 T17132 T17134 aux did,affect
R13297 T17133 T17134 neg not,affect
R13298 T17134 T17134 ROOT affect,affect
R13299 T17135 T17136 det the,survival
R13300 T17012 T17015 nsubj cells,decreased
R13301 T17136 T17134 dobj survival,affect
R13302 T17137 T17136 prep of,survival
R13303 T17013 T17015 advmod also,decreased
R13304 T17138 T17140 nummod LMP1,lymphocytes
R13305 T17139 T17140 amod transgenic,lymphocytes
R13306 T17140 T17137 pobj lymphocytes,of
R13307 T17141 T17140 cc or,lymphocytes
R13308 T17014 T17015 aux had,decreased
R13309 T17142 T17148 det the,cells
R13310 T17143 T17148 amod wild-type,cells
R13311 T17144 T17143 cc and,wild-type
R13312 T17015 T17016 amod decreased,levels
R13313 T17145 T17143 conj LMP1,wild-type
R13314 T17146 T17148 amod transgenic,cells
R13315 T17147 T17148 compound lymphoma,cells
R13316 T17016 T17024 nsubj levels,increased
R13317 T17148 T17140 conj cells,lymphocytes
R13318 T17149 T17151 punct (,7A
R13319 T17150 T17151 compound Figure,7A
R13320 T17151 T17140 appos 7A,lymphocytes
R13321 T17017 T17016 prep of,levels
R13322 T17152 T17151 punct ",",7A
R13323 T17153 T17151 conj 7C,7A
R13324 T17154 T17153 punct ",",7C
R13325 T17018 T17017 pobj p27,of
R13326 T17155 T17153 cc and,7C
R13327 T17156 T17153 conj 7E,7C
R13328 T17157 T17153 punct ),7C
R13329 T17158 T17134 punct .,affect
R13330 T17019 T17016 prep with,levels
R13331 T17159 T17160 det This,lack
R13332 T17160 T17165 nsubj lack,confirmed
R13333 T17161 T17160 prep of,lack
R13334 T17162 T17161 pobj effect,of
R13335 T17020 T17019 pobj phosphorylation,with
R13336 T17163 T17160 prep by,lack
R13337 T17164 T17163 pobj rapamycin,by
R13338 T17165 T17165 ROOT confirmed,confirmed
R13339 T17021 T17020 prep of,phosphorylation
R13340 T17166 T17167 det the,absence
R13341 T17167 T17165 dobj absence,confirmed
R13342 T17168 T17167 prep of,absence
R13343 T17022 T17021 pobj Rb,of
R13344 T17169 T17171 amod activated,levels
R13345 T17170 T17171 compound p-mTOR,levels
R13346 T17171 T17168 pobj levels,of
R13347 T17172 T17174 punct (,6B
R13348 T17173 T17174 compound Figure,6B
R13349 T17174 T17171 appos 6B,levels
R13350 T17023 T17016 cc and,levels
R13351 T17175 T17174 punct ),6B
R13352 T17176 T17165 punct .,confirmed
R13353 T17177 T17178 det These,findings
R13354 T17024 T16995 conj increased,induces
R13355 T17178 T17179 nsubj findings,suggest
R13356 T17179 T17179 ROOT suggest,suggest
R13357 T17180 T17184 mark that,contribute
R13358 T17025 T17032 nmod Cdk2,]
R13359 T17181 T17183 amod other,targets
R13360 T17182 T17183 compound Akt,targets
R13361 T17183 T17184 nsubj targets,contribute
R13362 T17184 T17179 ccomp contribute,suggest
R13363 T17026 T17028 punct (,6C
R13364 T17185 T17184 prep to,contribute
R13365 T17186 T17187 amod malignant,progression
R13366 T17187 T17185 pobj progression,to
R13367 T17027 T17028 compound Figure,6C
R13368 T17188 T17179 punct .,suggest
R13369 T17189 T17191 nummod One,target
R13370 T17190 T17191 amod key,target
R13371 T17191 T17192 nsubj target,is
R13372 T17028 T17025 appos 6C,Cdk2
R13373 T17192 T17192 ROOT is,is
R13374 T17193 T17192 acomp likely,is
R13375 T17194 T17195 det the,inhibition
R13376 T17029 T17028 punct ),6C
R13377 T17195 T17192 attr inhibition,is
R13378 T17196 T17195 prep of,inhibition
R13379 T17197 T17200 det the,factors
R13380 T17030 T17025 conj [,Cdk2
R13381 T17198 T17200 amod Fox01,factors
R13382 T17199 T17200 compound transcription,factors
R13383 T17200 T17196 pobj factors,of
R13384 T17031 T17032 nummod 66,]
R13385 T17201 T17192 punct .,is
R13386 T17202 T17214 nsubj Repression,inhibit
R13387 T17203 T17202 prep of,Repression
R13389 T17204 T17207 det the,factor
R13390 T17205 T17207 amod pro-apoptotic,factor
R13391 T17206 T17207 compound transcription,factor
R13392 T17207 T17203 pobj factor,of
R13394 T17208 T17202 conj FoxO1,Repression
R13395 T17209 T17214 prep in,inhibit
R13396 T17210 T17212 det a,manner
R13401 T17214 T17214 ROOT inhibit,inhibit
R13402 T17229 T17214 punct .,inhibit
R13403 T17215 T17214 dobj expression,inhibit
R13404 T17216 T17215 prep of,expression
R13405 T17217 T17216 pobj bcl6,of
R13406 T17230 T17233 nsubjpass It,shown
R13407 T17218 T17214 punct ",",inhibit
R13408 T17219 T17221 det a,factor
R13409 T17231 T17233 aux has,shown
R13410 T17220 T17221 compound transcription,factor
R13411 T17221 T17214 dobj factor,inhibit
R13412 T17222 T17221 amod necessary,factor
R13413 T17232 T17233 auxpass been,shown
R13414 T17223 T17221 prep for,factor
R13415 T17224 T17225 compound GC,formation
R13416 T17225 T17223 pobj formation,for
R13417 T17233 T17233 ROOT shown,shown
R13418 T17234 T17242 mark that,inhibits
R13419 T17235 T17242 nsubj overstimulation,inhibits
R13420 T17323 T17322 prep of,activation
R13421 T17324 T17323 pobj Akt,of
R13422 T17236 T17235 prep of,overstimulation
R13423 T17325 T17322 cc and,activation
R13424 T17237 T17236 pobj CD40,of
R13425 T17326 T17327 det the,lack
R13426 T17327 T17322 conj lack,activation
R13427 T17238 T17235 acl signaling,overstimulation
R13428 T17328 T17327 prep of,lack
R13429 T17329 T17328 pobj Fox01,of
R13430 T17239 T17238 prep with,signaling
R13431 T17330 T17327 prep in,lack
R13432 T17331 T17333 det the,cells
R13433 T17332 T17333 compound lymphoma,cells
R13434 T17240 T17241 amod agonistic,antibodies
R13435 T17333 T17330 pobj cells,in
R13436 T17334 T17364 advcl suggest,contribute
R13437 T17241 T17239 pobj antibodies,with
R13438 T17335 T17337 mark that,affects
R13439 T17336 T17337 nsubj LMP1,affects
R13440 T17337 T17334 ccomp affects,suggest
R13441 T17338 T17337 dobj bcl6,affects
R13442 T17242 T17233 ccomp inhibits,shown
R13443 T17339 T17337 cc and,affects
R13444 T17340 T17341 compound GC,formation
R13445 T17243 T17244 compound GC,formation
R13446 T17341 T17337 conj formation,affects
R13447 T17342 T17341 prep through,formation
R13448 T17343 T17344 det this,pathway
R13449 T17344 T17342 pobj pathway,through
R13450 T17345 T17344 punct ",",pathway
R13451 T17346 T17341 conj regulation,formation
R13452 T17244 T17242 dobj formation,inhibits
R13453 T17347 T17341 prep of,formation
R13454 T17348 T17350 amod other,targets
R13455 T17245 T17247 nmod [,]
R13456 T17246 T17247 nummod 71,]
R13457 T17349 T17350 compound Forkhead,targets
R13458 T17350 T17347 pobj targets,of
R13459 T17351 T17350 acl involved,targets
R13460 T17247 T17244 appos ],formation
R13461 T17352 T17351 prep in,involved
R13462 T17353 T17354 compound cell,cycle
R13463 T17354 T17355 compound cycle,progression
R13464 T17248 T17233 punct .,shown
R13465 T17355 T17352 pobj progression,in
R13466 T17356 T17350 punct ",",targets
R13467 T17357 T17358 amod such,as
R13468 T17249 T17261 advmod Similarly,are
R13469 T17358 T17350 prep as,targets
R13470 T17359 T17358 pobj p27,as
R13471 T17360 T17359 cc and,p27
R13472 T17250 T17261 punct ",",are
R13473 T17361 T17364 nsubj CyclinD2,contribute
R13474 T17362 T17361 punct ",",CyclinD2
R13475 T17363 T17361 amod likely,CyclinD2
R13476 T17251 T17261 prep due,are
R13477 T17364 T17364 ROOT contribute,contribute
R13478 T17365 T17364 prep to,contribute
R13479 T17252 T17251 pcomp to,due
R13480 T17366 T17367 compound malignant,transformation
R13481 T17367 T17365 pobj transformation,to
R13482 T17368 T17364 punct .,contribute
R13483 T17253 T17251 pobj mimicry,due
R13484 T17369 T17378 advmod Indeed,correlated
R13485 T17370 T17378 punct ",",correlated
R13486 T17371 T17378 nsubj loss,correlated
R13487 T17254 T17253 prep of,mimicry
R13488 T17372 T17371 prep of,loss
R13489 T17373 T17374 amod FoxO1,expression
R13490 T17255 T17254 pobj CD40,of
R13491 T17374 T17372 pobj expression,of
R13492 T17375 T17371 prep in,loss
R13493 T17376 T17377 compound lymphoma,cells
R13494 T17256 T17251 pcomp signaling,due
R13495 T17377 T17375 pobj cells,in
R13496 T17257 T17261 punct ",",are
R13497 T17378 T17378 ROOT correlated,correlated
R13498 T17258 T17260 amod transgenic,mice
R13499 T17379 T17378 prep with,correlated
R13500 T17259 T17260 compound LMP1,mice
R13501 T17260 T17261 nsubj mice,are
R13502 T17380 T17381 det a,loss
R13503 T17261 T17261 ROOT are,are
R13504 T17381 T17379 pobj loss,with
R13505 T17262 T17261 advmod also,are
R13506 T17263 T17261 acomp defective,are
R13507 T17382 T17381 prep of,loss
R13508 T17264 T17263 prep in,defective
R13509 T17383 T17382 pobj p27,of
R13510 T17265 T17266 compound GC,formation
R13511 T17384 T17386 punct (,6B
R13512 T17266 T17269 compound formation,]
R13513 T17385 T17386 compound Figure,6B
R13514 T17267 T17269 compound [,]
R13515 T17386 T17381 appos 6B,loss
R13516 T17387 T17386 cc and,6B
R13517 T17388 T17386 conj 6C,6B
R13518 T17268 T17269 compound "23,49",]
R13519 T17389 T17386 punct ),6B
R13520 T17390 T17378 punct .,correlated
R13521 T17391 T17395 nsubj CyclinD2,shown
R13522 T17269 T17264 pobj ],in
R13523 T17392 T17395 aux has,shown
R13524 T17393 T17395 advmod also,shown
R13525 T17270 T17261 punct .,are
R13526 T17394 T17395 auxpass been,shown
R13527 T17395 T17395 ROOT shown,shown
R13528 T17396 T17398 aux to,upregulated
R13529 T17271 T17272 det The,constitutive
R13530 T17397 T17398 auxpass be,upregulated
R13531 T17398 T17395 xcomp upregulated,shown
R13532 T17399 T17398 agent by,upregulated
R13533 T17400 T17399 pobj LMP1,by
R13534 T17272 T17273 nsubj constitutive,signaling
R13535 T17401 T17398 prep through,upregulated
R13536 T17402 T17401 pobj release,through
R13537 T17273 T17273 ROOT signaling,signaling
R13538 T17403 T17402 prep of,release
R13539 T17404 T17405 amod FoxO1-mediated,repression
R13540 T17405 T17403 pobj repression,of
R13541 T17274 T17273 prep by,signaling
R13542 T17406 T17408 nmod [,]
R13543 T17407 T17408 nummod 70,]
R13544 T17408 T17402 appos ],release
R13545 T17409 T17395 punct .,shown
R13546 T17410 T17421 prep In,promotes
R13547 T17411 T17410 pobj summary,In
R13548 T17412 T17421 punct ",",promotes
R13549 T17275 T17277 nummod LMP1,blocks
R13550 T17413 T17421 prep in,promotes
R13551 T17414 T17416 det this,model
R13552 T17415 T17416 amod transgenic,model
R13553 T17276 T17277 amod likely,blocks
R13554 T17416 T17413 pobj model,in
R13555 T17417 T17416 prep of,model
R13556 T17418 T17417 pobj lymphomagenesis,of
R13557 T17277 T17274 pobj blocks,by
R13558 T17419 T17421 punct ",",promotes
R13559 T17278 T17279 compound GC,formation
R13560 T17279 T17273 dobj formation,signaling
R13561 T17420 T17421 nsubj LMP1,promotes
R13562 T17280 T17273 prep through,signaling
R13563 T17421 T17421 ROOT promotes,promotes
R13564 T17422 T17421 dobj malignancy,promotes
R13565 T17281 T17280 pobj downregulation,through
R13566 T17423 T17422 prep in,malignancy
R13567 T17424 T17425 amod B-1a,cells
R13568 T17282 T17281 prep of,downregulation
R13569 T17425 T17423 pobj cells,in
R13570 T17426 T17422 punct ",",malignancy
R13571 T17427 T17428 det a,population
R13572 T17428 T17422 appos population,malignancy
R13573 T17283 T17282 pobj bcl6,of
R13574 T17429 T17431 nsubjpass that,predisposed
R13575 T17430 T17431 auxpass is,predisposed
R13576 T17431 T17428 relcl predisposed,population
R13577 T17284 T17273 punct .,signaling
R13578 T17432 T17431 prep to,predisposed
R13579 T17433 T17434 amod clonal,expansion
R13580 T17434 T17432 pobj expansion,to
R13581 T17285 T17289 advmod Interestingly,indicate
R13582 T17435 T17434 prep with,expansion
R13583 T17436 T17435 pobj age,with
R13584 T17437 T17421 punct .,promotes
R13585 T17286 T17289 punct ",",indicate
R13586 T17438 T17440 det The,lymphocytes
R13587 T17439 T17440 amod malignant,lymphocytes
R13588 T17440 T17442 nsubjpass lymphocytes,distinguished
R13589 T17287 T17288 amod clinical,studies
R13590 T17441 T17442 auxpass were,distinguished
R13591 T17442 T17442 ROOT distinguished,distinguished
R13592 T17443 T17442 agent by,distinguished
R13593 T17288 T17289 nsubj studies,indicate
R13594 T17444 T17445 advmod constitutively,active
R13595 T17445 T17447 amod active,signaling
R13596 T17446 T17447 amod Stat3,signaling
R13597 T17447 T17443 pobj signaling,by
R13598 T17448 T17449 punct ",",decreased
R13599 T17449 T17442 conj decreased,distinguished
R13600 T17450 T17449 nsubj p27,decreased
R13601 T17289 T17289 ROOT indicate,indicate
R13602 T17290 T17296 mark that,are
R13603 T17451 T17449 punct ",",decreased
R13604 T17452 T17449 cc and,decreased
R13605 T17291 T17296 nsubj expression,are
R13606 T17453 T17449 conj activated,decreased
R13607 T17454 T17457 nmod Akt,pathways
R13608 T17455 T17454 cc and,Akt
R13609 T17456 T17454 conj NFκB,Akt
R13610 T17292 T17291 prep of,expression
R13611 T17457 T17453 dobj pathways,activated
R13612 T17458 T17457 punct ",",pathways
R13613 T17459 T17457 appos properties,pathways
R13614 T17293 T17292 pobj LMP1,of
R13615 T17460 T17462 nsubjpass that,associated
R13616 T17461 T17462 auxpass are,associated
R13617 T17462 T17459 relcl associated,properties
R13618 T17294 T17293 cc and,LMP1
R13619 T17463 T17462 prep with,associated
R13620 T17464 T17463 pcomp promoting,with
R13621 T17465 T17466 det the,growth
R13622 T17466 T17464 dobj growth,promoting
R13623 T17467 T17466 cc and,growth
R13624 T17295 T17293 conj bcl6,LMP1
R13625 T17468 T17466 conj survival,growth
R13626 T17469 T17466 prep of,growth
R13627 T17470 T17471 compound B,lymphocytes
R13628 T17471 T17469 pobj lymphocytes,of
R13629 T17296 T17289 ccomp are,indicate
R13630 T17472 T17449 punct .,decreased
R13631 T17473 T17484 advmod Importantly,required
R13632 T17474 T17484 punct ",",required
R13633 T17297 T17298 advmod mutually,exclusive
R13634 T17475 T17481 nmod Akt,pathways
R13635 T17476 T17475 punct ",",Akt
R13636 T17477 T17475 conj NFκB,Akt
R13637 T17478 T17477 punct ",",NFκB
R13638 T17298 T17296 acomp exclusive,are
R13639 T17479 T17477 cc and,NFκB
R13640 T17480 T17481 amod Stat3,pathways
R13641 T17299 T17298 prep in,exclusive
R13642 T17481 T17484 nsubjpass pathways,required
R13643 T17482 T17484 auxpass were,required
R13644 T17483 T17484 advmod critically,required
R13645 T17484 T17484 ROOT required,required
R13646 T17300 T17304 amod non-HD,[
R13647 T17485 T17484 prep for,required
R13648 T17486 T17487 det the,growth
R13649 T17487 T17485 pobj growth,for
R13650 T17488 T17487 cc and,growth
R13651 T17489 T17487 conj survival,growth
R13652 T17490 T17489 prep of,survival
R13653 T17301 T17300 cc and,non-HD
R13654 T17491 T17492 amod malignant,lymphocytes
R13655 T17492 T17490 pobj lymphocytes,of
R13656 T17493 T17495 advmod as,as
R13657 T17494 T17495 advmod well,as
R13658 T17302 T17300 conj classical,non-HD
R13659 T17495 T17487 cc as,growth
R13660 T17496 T17499 amod healthy,lymphocytes
R13661 T17303 T17304 compound HD,[
R13662 T17497 T17499 nummod LMP1,lymphocytes
R13663 T17304 T17299 pobj [,in
R13664 T17498 T17499 amod transgenic,lymphocytes
R13665 T17499 T17487 conj lymphocytes,growth
R13666 T17305 T17306 nummod "72,73",]
R13667 T17500 T17484 punct .,required
R13668 T17501 T17502 det The,growth
R13669 T17502 T17507 nsubj growth,requires
R13670 T17503 T17502 prep of,growth
R13671 T17306 T17296 npadvmod ],are
R13672 T17504 T17505 amod EBV-transformed,lymphocytes
R13673 T17307 T17289 punct .,indicate
R13674 T17505 T17503 pobj lymphocytes,of
R13675 T17506 T17507 advmod also,requires
R13676 T17308 T17314 advmod Thus,mirror
R13677 T17507 T17507 ROOT requires,requires
R13678 T17508 T17507 dobj activation,requires
R13679 T17509 T17508 prep of,activation
R13680 T17510 T17509 pobj NFκB,of
R13681 T17309 T17314 punct ",",mirror
R13682 T17511 T17507 punct ",",requires
R13683 T17512 T17507 cc and,requires
R13684 T17513 T17514 det these,studies
R13685 T17310 T17313 det the,lymphomas
R13686 T17514 T17515 nsubj studies,provide
R13687 T17515 T17507 conj provide,requires
R13688 T17516 T17515 dobj insight,provide
R13689 T17311 T17313 nmod LMP1,lymphomas
R13690 T17312 T17313 amod transgenic,lymphomas
R13691 T17313 T17314 nsubj lymphomas,mirror
R13692 T17314 T17314 ROOT mirror,mirror
R13693 T17517 T17516 prep into,insight
R13694 T17518 T17520 advmod how,contributes
R13695 T17315 T17314 dobj aspects,mirror
R13696 T17519 T17520 nsubj LMP1,contributes
R13697 T17520 T17517 pcomp contributes,into
R13698 T17521 T17520 prep to,contributes
R13699 T17522 T17523 amod EBV-associated,transformation
R13700 T17523 T17521 pobj transformation,to
R13701 T17524 T17515 punct .,provide
R13702 T17316 T17315 prep of,aspects
R13703 T17525 T17527 det The,lymphomas
R13704 T17526 T17527 amod transgenic,lymphomas
R13705 T17527 T17528 nsubj lymphomas,mirror
R13706 T17317 T17318 compound EBV-induced,HD
R13707 T17528 T17528 ROOT mirror,mirror
R13708 T17529 T17530 amod multiple,aspects
R13709 T17530 T17528 dobj aspects,mirror
R13710 T17318 T17316 pobj HD,of
R13711 T17319 T17314 punct .,mirror
R13712 T17531 T17530 prep of,aspects
R13713 T17320 T17334 mark Although,suggest
R13714 T17532 T17533 amod EBV-induced,tumors
R13715 T17533 T17531 pobj tumors,of
R13716 T17534 T17528 cc and,mirror
R13717 T17321 T17322 det the,activation
R13718 T17535 T17528 conj suggest,mirror
R13719 T17536 T17543 mark that,are
R13720 T17322 T17334 nsubj activation,suggest
R13721 T17537 T17543 prep in,are
R13722 T17538 T17537 pobj vivo,in
R13723 T17539 T17540 det these,properties
R13725 T17540 T17538 dobj properties,vivo
R13726 T17541 T17538 prep of,vivo
R13727 T17542 T17541 pobj LMP1,of
R13728 T17543 T17535 ccomp are,suggest
R13729 T17544 T17545 amod major,factors
R13730 T17545 T17543 attr factors,are
R13731 T17546 T17545 prep in,factors
R13732 T17547 T17548 det the,development
R13733 T17548 T17546 pobj development,in
R13734 T17549 T17548 prep of,development
R13735 T17550 T17549 pobj cancer,of
R13736 T17551 T17528 punct .,mirror
R14187 T18431 T18432 compound Transgenic,mice
R14188 T18432 T18432 ROOT mice,mice
R14189 T18433 T18432 punct .,mice
R14190 T18434 T18448 nsubjpass Generation,described
R14191 T18435 T18434 prep of,Generation
R14192 T18436 T18437 compound LMP1,mice
R14193 T18437 T18435 pobj mice,of
R14194 T18438 T18434 prep under,Generation
R14195 T18439 T18443 det the,promoter
R14196 T18440 T18443 nmod Ig,promoter
R14197 T18441 T18443 amod heavy,promoter
R14198 T18442 T18443 compound chain,promoter
R14199 T18443 T18438 pobj promoter,under
R14200 T18444 T18443 cc and,promoter
R14201 T18445 T18443 conj enhancer,promoter
R14202 T18446 T18448 aux have,described
R14203 T18447 T18448 auxpass been,described
R14204 T18448 T18448 ROOT described,described
R14205 T18449 T18448 advmod previously,described
R14206 T18450 T18448 cc and,described
R14207 T18451 T18452 auxpass were,maintained
R14208 T18452 T18448 conj maintained,described
R14209 T18453 T18452 prep as,maintained
R14210 T18454 T18453 pobj heterozygotes,as
R14211 T18455 T18454 prep on,heterozygotes
R14212 T18456 T18458 det a,background
R14213 T18457 T18458 compound Balbc,background
R14214 T18458 T18455 pobj background,on
R14215 T18459 T18461 nmod [,]
R14216 T18460 T18461 nummod 26,]
R14217 T18461 T18458 appos ],background
R14218 T18462 T18448 punct .,described
R14219 T18463 T18464 nummod LMP1,mice
R14220 T18464 T18466 nsubjpass mice,genotyped
R14221 T18465 T18466 auxpass were,genotyped
R14222 T18466 T18466 ROOT genotyped,genotyped
R14223 T18467 T18466 agent by,genotyped
R14224 T18468 T18469 compound Southern,blot
R14225 T18469 T18467 pobj blot,by
R14226 T18470 T18469 cc and,blot
R14227 T18471 T18472 compound PCR,analysis
R14228 T18472 T18469 conj analysis,blot
R14229 T18473 T18472 prep of,analysis
R14230 T18474 T18475 compound tail,DNA
R14231 T18475 T18473 pobj DNA,of
R14232 T18476 T18477 mark as,described
R14233 T18477 T18466 advcl described,genotyped
R14234 T18478 T18481 advmod previously,]
R14235 T18479 T18481 nmod [,]
R14236 T18480 T18481 nummod 26,]
R14237 T18481 T18477 dobj ],described
R14238 T18482 T18466 punct .,genotyped
R14239 T18483 T18488 nsubjpass Spleen,fixed
R14240 T18484 T18483 cc and,Spleen
R14241 T18485 T18486 compound liver,sections
R14242 T18486 T18488 nsubjpass sections,fixed
R14243 T18487 T18488 auxpass were,fixed
R14244 T18488 T18488 ROOT fixed,fixed
R14245 T18489 T18488 prep in,fixed
R14246 T18490 T18491 nummod 4,%
R14247 T18491 T18492 compound %,paraformaldehyde
R14248 T18492 T18489 pobj paraformaldehyde,in
R14249 T18493 T18488 cc and,fixed
R14250 T18494 T18488 conj embedded,fixed
R14251 T18495 T18494 prep in,embedded
R14252 T18496 T18495 pobj paraffin,in
R14253 T18497 T18494 punct ",",embedded
R14254 T18498 T18494 cc and,embedded
R14255 T18499 T18500 amod 5-μm,sections
R14256 T18500 T18502 nsubjpass sections,stained
R14257 T18501 T18502 auxpass were,stained
R14258 T18502 T18494 conj stained,embedded
R14259 T18503 T18502 prep with,stained
R14260 T18504 T18503 pobj hematoxylin,with
R14261 T18505 T18504 cc and,hematoxylin
R14262 T18506 T18504 conj eosin,hematoxylin
R14263 T18507 T18502 prep for,stained
R14264 T18508 T18509 amod histopathological,analysis
R14265 T18509 T18507 pobj analysis,for
R14266 T18510 T18502 punct .,stained
R14267 T18511 T18513 nsubjpass Lymphomas,passaged
R14268 T18512 T18513 auxpass were,passaged
R14269 T18513 T18513 ROOT passaged,passaged
R14270 T18514 T18513 agent by,passaged
R14271 T18515 T18516 amod intraperitoneal,injection
R14272 T18516 T18514 pobj injection,by
R14273 T18517 T18516 prep of,injection
R14274 T18518 T18521 nummod 1,splenocytes
R14275 T18519 T18521 nummod ×,splenocytes
R14276 T18520 T18521 nummod 108,splenocytes
R14277 T18521 T18517 pobj splenocytes,of
R14278 T18522 T18516 prep into,injection
R14279 T18523 T18524 compound SCID,mice
R14280 T18524 T18522 pobj mice,into
R14281 T18525 T18513 cc and,passaged
R14282 T18526 T18513 conj sacrificed,passaged
R14283 T18527 T18526 prep upon,sacrificed
R14284 T18528 T18527 pobj development,upon
R14285 T18529 T18528 prep of,development
R14286 T18530 T18532 det an,abdomen
R14287 T18531 T18532 amod extended,abdomen
R14288 T18532 T18529 pobj abdomen,of
R14289 T18533 T18513 punct .,passaged
R14290 T18534 T18536 nsubjpass Animals,housed
R14291 T18535 T18536 auxpass were,housed
R14292 T18536 T18536 ROOT housed,housed
R14293 T18537 T18536 prep in,housed
R14294 T18538 T18539 det the,Association
R14295 T18539 T18537 pobj Association,in
R14296 T18540 T18539 prep for,Association
R14297 T18541 T18540 pobj Assessment,for
R14298 T18542 T18541 cc and,Assessment
R14299 T18543 T18547 nsubj Accreditation,approved
R14300 T18544 T18543 prep for,Accreditation
R14301 T18545 T18546 compound Animal,Care
R14302 T18546 T18544 pobj Care,for
R14303 T18547 T18536 advcl approved,housed
R14304 T18548 T18549 compound animal,facility
R14305 T18549 T18547 dobj facility,approved
R14306 T18550 T18547 prep at,approved
R14307 T18551 T18552 det the,University
R14308 T18552 T18550 pobj University,at
R14309 T18553 T18552 prep of,University
R14310 T18554 T18555 compound North,Carolina
R14311 T18555 T18553 pobj Carolina,of
R14312 T18556 T18552 prep at,University
R14313 T18557 T18558 compound Chapel,Hill
R14314 T18558 T18556 pobj Hill,at
R14315 T18559 T18547 punct .,approved
R14316 T18560 T18561 det All,protocols
R14317 T18561 T18563 nsubjpass protocols,approved
R14318 T18562 T18563 auxpass were,approved
R14319 T18563 T18563 ROOT approved,approved
R14320 T18564 T18563 agent by,approved
R14321 T18565 T18571 det the,Committee
R14322 T18566 T18568 compound Institutional,Care
R14323 T18567 T18568 compound Animal,Care
R14324 T18568 T18571 nmod Care,Committee
R14325 T18569 T18568 cc and,Care
R14326 T18570 T18571 compound Use,Committee
R14327 T18571 T18564 pobj Committee,by
R14328 T18572 T18563 punct .,approved
R14513 T18800 T18800 ROOT Isolation,Isolation
R14514 T18801 T18800 cc and,Isolation
R14515 T18802 T18800 conj growth,Isolation
R14516 T18803 T18802 prep of,growth
R14517 T18804 T18805 compound B,cells
R14518 T18805 T18803 pobj cells,of
R14519 T18806 T18800 punct .,Isolation
R14520 T18807 T18809 nsubjpass Splenocytes,prepared
R14521 T18808 T18809 auxpass were,prepared
R14522 T18809 T18809 ROOT prepared,prepared
R14523 T18810 T18809 agent by,prepared
R14524 T18811 T18810 pcomp homogenizing,by
R14525 T18812 T18813 compound spleen,tissue
R14526 T18813 T18811 dobj tissue,homogenizing
R14527 T18814 T18811 prep with,homogenizing
R14528 T18815 T18817 nummod two,slides
R14529 T18816 T18817 amod frosted,slides
R14530 T18817 T18814 pobj slides,with
R14531 T18818 T18817 cc and,slides
R14532 T18819 T18817 conj debris,slides
R14533 T18820 T18821 auxpass was,filtered
R14534 T18821 T18809 conj filtered,prepared
R14535 T18822 T18821 prep through,filtered
R14536 T18823 T18826 det a,strainer
R14537 T18824 T18825 amod 100-μm,cell
R14538 T18825 T18826 compound cell,strainer
R14539 T18826 T18822 pobj strainer,through
R14540 T18827 T18809 punct .,prepared
R14541 T18828 T18830 nsubjpass Erythrocytes,lysed
R14542 T18829 T18830 auxpass were,lysed
R14543 T18830 T18830 ROOT lysed,lysed
R14544 T18831 T18830 advcl using,lysed
R14545 T18832 T18833 nummod 0.8,%
R14546 T18833 T18836 compound %,solution
R14547 T18834 T18835 compound ammonium,chloride
R14548 T18835 T18836 compound chloride,solution
R14549 T18836 T18831 dobj solution,using
R14550 T18837 T18839 punct (,Technologies
R14551 T18838 T18839 compound StemCell,Technologies
R14552 T18839 T18836 appos Technologies,solution
R14553 T18840 T18836 punct ),solution
R14554 T18841 T18831 prep for,using
R14555 T18842 T18843 nummod 10,min
R14556 T18843 T18841 pobj min,for
R14557 T18844 T18843 prep on,min
R14558 T18845 T18844 pobj ice,on
R14559 T18846 T18830 cc and,lysed
R14560 T18847 T18830 conj washed,lysed
R14561 T18848 T18847 advmod twice,washed
R14562 T18849 T18847 prep with,washed
R14563 T18850 T18849 pobj PBS,with
R14564 T18851 T18830 punct .,lysed
R14565 T18852 T18853 amod B,cells
R14566 T18853 T18855 nsubjpass cells,isolated
R14567 T18854 T18855 auxpass were,isolated
R14568 T18855 T18855 ROOT isolated,isolated
R14569 T18856 T18855 advcl using,isolated
R14570 T18857 T18858 compound CD19-MACS,beads
R14571 T18858 T18856 dobj beads,using
R14572 T18859 T18855 prep according,isolated
R14573 T18860 T18859 prep to,according
R14574 T18861 T18862 det the,manufacturer
R14575 T18862 T18864 poss manufacturer,instructions
R14576 T18863 T18862 case 's,manufacturer
R14577 T18864 T18860 pobj instructions,to
R14578 T18865 T18867 punct (,Biotec
R14579 T18866 T18867 compound Miltenyi,Biotec
R14580 T18867 T18864 appos Biotec,instructions
R14581 T18868 T18867 punct ),Biotec
R14582 T18869 T18855 cc and,isolated
R14583 T18870 T18855 conj grown,isolated
R14584 T18871 T18870 prep in,grown
R14585 T18872 T18874 poss Iscove,medium
R14586 T18873 T18872 case 's,Iscove
R14587 T18874 T18871 pobj medium,in
R14588 T18875 T18874 acl supplemented,medium
R14589 T18876 T18875 prep with,supplemented
R14590 T18877 T18882 amod heat-inactivated,serum
R14591 T18878 T18879 nummod 10,%
R14592 T18879 T18882 nmod %,serum
R14593 T18880 T18882 amod fetal,serum
R14594 T18881 T18882 amod bovine,serum
R14595 T18882 T18876 pobj serum,with
R14596 T18883 T18882 cc and,serum
R14597 T18884 T18882 conj antibiotic/antimycotic,serum
R14598 T18885 T18884 punct (,antibiotic/antimycotic
R14599 T18886 T18884 appos GIBCO,antibiotic/antimycotic
R14600 T18887 T18884 punct ),antibiotic/antimycotic
R14601 T18888 T18855 punct .,isolated
R14602 T18889 T18890 nsubj Splenocytes,isolated
R14603 T18890 T18890 ROOT isolated,isolated
R14604 T18891 T18890 prep from,isolated
R14605 T18892 T18893 amod SCID-passaged,lymphomas
R14606 T18893 T18891 pobj lymphomas,from
R14607 T18894 T18890 dep consisted,isolated
R14608 T18895 T18894 prep of,consisted
R14609 T18896 T18897 nummod 80,%
R14610 T18897 T18895 pobj %,of
R14611 T18898 T18899 nummod 90,%
R14612 T18899 T18901 compound %,cells
R14613 T18900 T18901 compound B,cells
R14614 T18901 T18890 dobj cells,isolated
R14615 T18902 T18903 mark as,determined
R14616 T18903 T18890 advcl determined,isolated
R14617 T18904 T18903 agent by,determined
R14618 T18905 T18906 compound flow,cytometry
R14619 T18906 T18904 pobj cytometry,by
R14620 T18907 T18890 punct ",",isolated
R14621 T18908 T18890 cc and,isolated
R14622 T18909 T18890 conj were,isolated
R14623 T18910 T18909 advmod hence,were
R14624 T18911 T18912 neg not,further
R14625 T18912 T18913 advmod further,purified
R14626 T18913 T18909 acomp purified,were
R14627 T18914 T18913 prep with,purified
R14628 T18915 T18916 compound CD19-MACS,beads
R14629 T18916 T18914 pobj beads,with
R14630 T18917 T18890 punct .,isolated
R14631 T18918 T18920 nsubjpass Splenocytes,seeded
R14632 T18919 T18920 auxpass were,seeded
R14633 T18920 T18920 ROOT seeded,seeded
R14634 T18921 T18920 prep at,seeded
R14635 T18922 T18925 nummod 1.25,cells/ml
R14636 T18923 T18925 nummod ×,cells/ml
R14637 T18924 T18925 nummod 106,cells/ml
R14638 T18925 T18921 pobj cells/ml,at
R14639 T18926 T18925 cc and,cells/ml
R14640 T18927 T18934 advmod where,added
R14641 T18928 T18934 advmod applicable,added
R14642 T18929 T18934 punct ",",added
R14643 T18930 T18931 amod recombinant,mouse
R14644 T18931 T18932 compound mouse,IL4
R14645 T18932 T18934 nsubjpass IL4,added
R14646 T18933 T18934 auxpass was,added
R14647 T18934 T18920 advcl added,seeded
R14648 T18935 T18934 prep at,added
R14649 T18936 T18937 nummod 100,ng/ml
R14650 T18937 T18935 pobj ng/ml,at
R14651 T18938 T18937 punct ",",ng/ml
R14652 T18939 T18940 compound recombinant,mouse
R14653 T18940 T18941 compound mouse,IL10
R14654 T18941 T18937 appos IL10,ng/ml
R14655 T18942 T18941 prep at,IL10
R14656 T18943 T18944 nummod 10,ng/ml
R14657 T18944 T18942 pobj ng/ml,at
R14658 T18945 T18941 punct ",",IL10
R14659 T18946 T18937 cc and,ng/ml
R14660 T18947 T18950 compound rat,IL10
R14661 T18948 T18950 compound IgG1,IL10
R14662 T18949 T18950 compound anti-mouse,IL10
R14663 T18950 T18937 conj IL10,ng/ml
R14664 T18951 T18950 cc and,IL10
R14665 T18952 T18955 nmod rat,control
R14666 T18953 T18955 amod IgG1,control
R14667 T18954 T18955 compound isotype,control
R14668 T18955 T18950 conj control,IL10
R14669 T18956 T18955 prep at,control
R14670 T18957 T18958 nummod 10,μg
R14671 T18958 T18960 compound μg,ml
R14672 T18959 T18960 compound /,ml
R14673 T18960 T18956 pobj ml,at
R14674 T18961 T18963 punct (,Systems
R14675 T18962 T18963 compound R&D,Systems
R14676 T18963 T18960 appos Systems,ml
R14677 T18964 T18963 punct ),Systems
R14678 T18965 T18920 punct .,seeded
R14679 T18966 T18973 prep For,pulsed
R14680 T18967 T18969 compound BrdU,assays
R14681 T18968 T18969 compound incorporation,assays
R14682 T18969 T18966 pobj assays,For
R14683 T18970 T18973 punct ",",pulsed
R14684 T18971 T18973 nsubjpass splenocytes,pulsed
R14685 T18972 T18973 auxpass were,pulsed
R14686 T18973 T18973 ROOT pulsed,pulsed
R14687 T18974 T18973 prep for,pulsed
R14688 T18975 T18976 nummod 24,h
R14689 T18976 T18974 pobj h,for
R14690 T18977 T18976 prep with,h
R14691 T18978 T18983 nummod 10,post-harvest
R14692 T18979 T18980 compound μM,BrdU
R14693 T18980 T18983 nmod BrdU,post-harvest
R14694 T18981 T18980 nummod 1,BrdU
R14695 T18982 T18983 meta d,post-harvest
R14696 T18983 T18977 pobj post-harvest,with
R14697 T18984 T18973 punct .,pulsed
R14965 T19315 T19316 compound MTS,assay
R14966 T19316 T19316 ROOT assay,assay
R14967 T19317 T19316 punct .,assay
R14968 T19318 T19347 det The,performed
R14969 T19319 T19347 meta 3,performed
R14970 T19320 T19322 punct -,4
R14971 T19321 T19322 punct (,4
R14972 T19322 T19319 appos 4,3
R15004 T19354 T19355 compound cell,proliferation
R15005 T19355 T19356 compound proliferation,assay
R15006 T19356 T19348 dobj assay,using
R15007 T19357 T19356 punct (,assay
R15008 T19358 T19356 appos Promega,assay
R15009 T19359 T19356 punct ),assay
R15010 T19360 T19347 punct ",",performed
R15011 T19361 T19347 prep according,performed
R15012 T19362 T19361 prep to,according
R15013 T19363 T19365 poss manufacturer,instructions
R15014 T19364 T19363 case 's,manufacturer
R15015 T19365 T19362 pobj instructions,to
R15016 T19366 T19347 punct .,performed
R15017 T19367 T19373 prep For,cultured
R15018 T19368 T19369 nummod IL4,studies
R15019 T19369 T19367 pobj studies,For
R15020 T19370 T19373 punct ",",cultured
R15021 T19371 T19373 nsubjpass splenocytes,cultured
R15022 T19372 T19373 auxpass were,cultured
R15023 T19373 T19373 ROOT cultured,cultured
R15024 T19374 T19373 prep for,cultured
R15025 T19375 T19376 nummod 3,d
R15026 T19376 T19374 pobj d,for
R15027 T19377 T19373 prep in,cultured
R15028 T19378 T19379 det the,presence
R15029 T19379 T19377 pobj presence,in
R15030 T19380 T19379 cc or,presence
R15031 T19381 T19379 conj absence,presence
R15032 T19382 T19381 prep of,absence
R15033 T19383 T19385 nummod 100,IL4
R15034 T19384 T19385 amod ng/ml,IL4
R15035 T19385 T19382 pobj IL4,of
R15036 T19386 T19373 punct .,cultured
R15037 T19387 T19389 nsubjpass Cells,seeded
R15038 T19388 T19389 auxpass were,seeded
R15039 T19389 T19389 ROOT seeded,seeded
R15040 T19390 T19389 prep on,seeded
R15041 T19391 T19390 pobj day,on
R15042 T19392 T19391 nummod 3,day
R15043 T19393 T19389 prep in,seeded
R15044 T19394 T19393 pobj triplicate,in
R15045 T19395 T19389 prep in,seeded
R15046 T19396 T19398 det a,plate
R15047 T19397 T19398 amod 96-well,plate
R15048 T19398 T19395 pobj plate,in
R15049 T19399 T19389 prep at,seeded
R15050 T19400 T19403 nummod 2.5,cells/ml
R15051 T19401 T19403 nmod ×,cells/ml
R15052 T19402 T19403 nummod 106,cells/ml
R15053 T19403 T19399 pobj cells/ml,at
R15054 T19404 T19389 prep at,seeded
R15055 T19405 T19406 nummod 100,μl
R15056 T19406 T19404 pobj μl,at
R15057 T19407 T19408 advmod per,well
R15058 T19408 T19389 advmod well,seeded
R15059 T19409 T19389 punct .,seeded
R15060 T19410 T19411 compound MTS,reagent
R15061 T19411 T19413 nsubjpass reagent,added
R15062 T19412 T19413 auxpass was,added
R15063 T19413 T19428 ccomp added,subtracted
R15064 T19414 T19413 prep for,added
R15065 T19415 T19416 nummod 4,h
R15066 T19416 T19414 pobj h,for
R15067 T19417 T19416 cc and,h
R15068 T19418 T19416 conj absorbance,h
R15069 T19419 T19420 auxpass was,read
R15070 T19420 T19413 conj read,added
R15071 T19421 T19420 prep at,read
R15072 T19422 T19423 nummod 540,nm
R15073 T19423 T19421 pobj nm,at
R15074 T19424 T19428 punct ;,subtracted
R15075 T19425 T19428 nsubjpass values,subtracted
R15076 T19426 T19425 acl plotted,values
R15077 T19427 T19428 auxpass were,subtracted
R15078 T19428 T19428 ROOT subtracted,subtracted
R15079 T19429 T19428 prep from,subtracted
R15080 T19430 T19429 pobj blanks,from
R15081 T19431 T19428 punct .,subtracted
R15082 T19432 T19438 prep For,seeded
R15083 T19433 T19434 compound neutralization,assays
R15084 T19434 T19432 pobj assays,For
R15085 T19435 T19438 punct ",",seeded
R15086 T19436 T19438 nsubjpass splenocytes,seeded
R15087 T19437 T19438 auxpass were,seeded
R15088 T19438 T19438 ROOT seeded,seeded
R15089 T19439 T19438 prep at,seeded
R15090 T19440 T19441 nummod 5,×
R15091 T19441 T19439 pobj ×,at
R15092 T19442 T19443 nummod 106,cells/ml
R15093 T19443 T19441 appos cells/ml,×
R15094 T19444 T19438 prep at,seeded
R15095 T19445 T19446 nummod 100,μl
R15096 T19446 T19444 pobj μl,at
R15097 T19447 T19448 advmod per,well
R15098 T19448 T19438 advmod well,seeded
R15099 T19449 T19438 prep on,seeded
R15148 T19498 T19499 auxpass were,seeded
R15149 T19499 T19499 ROOT seeded,seeded
R15150 T19500 T19499 prep at,seeded
R15151 T19501 T19518 nummod 1,added
R15152 T19502 T19518 nsubjpass ×,added
R15153 T19503 T19504 nummod 107,cells/ml
R15154 T19504 T19502 appos cells/ml,×
R15155 T19505 T19504 prep at,cells/ml
R15156 T19506 T19507 nummod 100,μl
R15157 T19507 T19505 pobj μl,at
R15158 T19508 T19509 advmod per,well
R15159 T19509 T19510 advmod well,on
R15160 T19510 T19504 prep on,cells/ml
R15161 T19511 T19510 pobj day,on
R15162 T19512 T19511 prep of,day
R15163 T19513 T19512 pobj harvest,of
R15164 T19514 T19504 punct ",",cells/ml
R15165 T19515 T19504 cc and,cells/ml
R15166 T19516 T19504 conj inhibitors,cells/ml
R15167 T19517 T19518 auxpass were,added
R15168 T19518 T19499 conj added,seeded
R15169 T19519 T19518 prep at,added
R15170 T19520 T19521 det the,concentrations
R15171 T19521 T19519 pobj concentrations,at
R15172 T19522 T19521 acl indicated,concentrations
R15173 T19523 T19522 prep in,indicated
R15174 T19524 T19525 det the,figures
R15175 T19525 T19523 pobj figures,in
R15176 T19526 T19518 punct .,added
R15177 T19527 T19528 det The,inhibitors
R15178 T19528 T19528 ROOT inhibitors,inhibitors
R15179 T19529 T19528 appos BAY11,inhibitors
R15180 T19530 T19529 appos 7085,BAY11
R15181 T19531 T19529 punct ",",BAY11
R15182 T19532 T19529 appos rapamycin,BAY11
R15183 T19533 T19532 punct ",",rapamycin
R15184 T19534 T19532 conj triciribine,rapamycin
R15185 T19535 T19534 punct ",",triciribine
R15186 T19536 T19534 conj U0126,triciribine
R15187 T19537 T19536 punct ",",U0126
R15188 T19538 T19536 conj SB202190,U0126
R15189 T19539 T19538 punct ",",SB202190
R15190 T19540 T19538 cc and,SB202190
R15191 T19541 T19538 conj cucurbitacin,SB202190
R15192 T19542 T19544 nsubjpass I,purchased
R15193 T19543 T19544 auxpass were,purchased
R15194 T19544 T19528 relcl purchased,inhibitors
R15195 T19545 T19544 prep from,purchased
R15196 T19546 T19547 compound EMD,Biosciences
R15197 T19547 T19545 pobj Biosciences,from
R15198 T19548 T19544 punct .,purchased
R15199 T19549 T19558 prep For,induced
R15200 T19550 T19552 amod non-malignant,cultures
R15201 T19551 T19552 compound splenocyte,cultures
R15202 T19552 T19549 pobj cultures,For
R15203 T19553 T19558 punct ",",induced
R15204 T19554 T19556 compound B,activation
R15205 T19555 T19556 compound cell,activation
R15206 T19556 T19558 nsubjpass activation,induced
R15208 T19558 T19558 ROOT induced,induced
R15209 T19559 T19558 prep with,induced
R15210 T19560 T19561 nummod 10,μg
R15211 T19561 T19563 compound μg,ml
R15212 T19562 T19563 compound /,ml
R15213 T19563 T19559 pobj ml,with
R15214 T19564 T19563 prep of,ml
R15215 T19565 T19566 compound goat,F
R15216 T19566 T19564 pobj F,of
R15217 T19567 T19572 punct (,IgM
R15218 T19568 T19572 nmod ab,IgM
R15219 T19569 T19568 case ',ab
R15220 T19570 T19572 punct ),IgM
R15221 T19571 T19572 compound anti-mouse,IgM
R15222 T19572 T19563 appos IgM,ml
R15223 T19573 T19575 punct (,ImmunoResearch
R15224 T19574 T19575 compound Jackson,ImmunoResearch
R15225 T19575 T19572 appos ImmunoResearch,IgM
R15226 T19576 T19575 punct ),ImmunoResearch
R15227 T19577 T19558 punct .,induced
R15228 T19578 T19580 nsubjpass Cultures,pulsed
R15229 T19579 T19580 auxpass were,pulsed
R15230 T19580 T19580 ROOT pulsed,pulsed
R15231 T19581 T19580 prep for,pulsed
R15232 T19582 T19583 nummod 4,h
R15233 T19583 T19581 pobj h,for
R15234 T19584 T19583 prep with,h
R15235 T19585 T19586 compound MTS,reagent
R15236 T19586 T19584 pobj reagent,with
R15237 T19587 T19586 nummod 1,reagent
R15238 T19588 T19589 meta d,post-seeding
R15239 T19589 T19586 appos post-seeding,reagent
R15240 T19590 T19580 punct .,pulsed
R15411 T19824 T19824 ROOT Immunohistochemistry,Immunohistochemistry
R15412 T19825 T19824 punct .,Immunohistochemistry
R15413 T19826 T19828 amod Paraffin-embedded,sections
R15414 T19827 T19828 compound spleen,sections
R15415 T19828 T19830 nsubjpass sections,deparaffinized
R15416 T19829 T19830 auxpass were,deparaffinized
R15417 T19830 T19830 ROOT deparaffinized,deparaffinized
R15418 T19831 T19830 prep in,deparaffinized
R15419 T19832 T19831 pobj Histoclear,in
R15420 T19833 T19835 punct (,Diagnostics
R15421 T19834 T19835 compound National,Diagnostics
R15422 T19835 T19832 appos Diagnostics,Histoclear
R15423 T19836 T19835 punct ),Diagnostics
R15424 T19837 T19830 cc and,deparaffinized
R15425 T19838 T19830 conj rehydrated,deparaffinized
R15426 T19839 T19838 prep in,rehydrated
R15427 T19840 T19841 amod graded,ethanol
R15428 T19841 T19839 pobj ethanol,in
R15429 T19842 T19830 punct .,deparaffinized
R15430 T19843 T19844 nsubj Sections,were
R15431 T19844 T19844 ROOT were,were
R15432 T19845 T19844 attr antigen,were
R15433 T19846 T19845 acl retrieved,antigen
R15434 T19847 T19846 agent by,retrieved
R15435 T19848 T19847 pobj microwaving,by
R15436 T19849 T19848 prep in,microwaving
R15437 T19850 T19851 compound citrate,buffer
R15438 T19851 T19849 pobj buffer,in
R15439 T19852 T19853 punct (,pH
R15440 T19853 T19848 appos pH,microwaving
R15441 T19854 T19853 nummod 6.0,pH
R15442 T19855 T19853 punct ),pH
R15443 T19856 T19846 prep for,retrieved
R15444 T19857 T19858 nummod 15,min
R15445 T19858 T19856 pobj min,for
R15446 T19859 T19858 punct (,min
R15447 T19860 T19865 nummod LMP1,min
R15448 T19861 T19860 advmod staining,LMP1
R15449 T19862 T19860 punct ),LMP1
R15450 T19863 T19860 cc and,LMP1
R15451 T19864 T19860 conj 10,LMP1
R15452 T19865 T19858 appos min,min
R15453 T19866 T19868 punct (,staining
R15454 T19867 T19868 amod pStat3,staining
R15455 T19868 T19865 appos staining,min
R15456 T19869 T19865 punct ),min
R15457 T19870 T19844 punct .,were
R15458 T19871 T19877 prep For,blocked
R15459 T19872 T19873 nsubj LMP1,staining
R15460 T19873 T19871 pobj staining,For
R15461 T19874 T19877 punct ",",blocked
R15462 T19875 T19877 nsubjpass sections,blocked
R15463 T19876 T19877 auxpass were,blocked
R15464 T19877 T19877 ROOT blocked,blocked
R15465 T19878 T19877 prep with,blocked
R15466 T19879 T19880 nummod 1,%
R15467 T19880 T19881 compound %,BSA
R15468 T19881 T19878 pobj BSA,with
R15469 T19882 T19877 cc and,blocked
R15470 T19883 T19884 nummod 0.1,%
R15471 T19884 T19877 conj %,blocked
R15472 T19885 T19886 amod cold,fish
R15473 T19886 T19888 compound fish,gelatin
R15474 T19887 T19888 compound skin,gelatin
R15475 T19888 T19889 nsubj gelatin,followed
R15476 T19889 T19884 relcl followed,%
R15477 T19890 T19889 prep with,followed
R15478 T19891 T19892 compound streptavidin/biotin,block
R15479 T19892 T19890 pobj block,with
R15480 T19893 T19895 punct (,Labs
R15481 T19894 T19895 compound Vector,Labs
R15482 T19895 T19892 appos Labs,block
R15483 T19896 T19895 punct ),Labs
R15484 T19897 T19889 punct .,followed
R15485 T19898 T19900 compound Rat,anti-LMP1
R15486 T19899 T19900 compound IgG,anti-LMP1
R15487 T19900 T19910 nsubjpass anti-LMP1,used
R15488 T19901 T19910 punct (,used
R15489 T19902 T19910 nsubjpass clones,used
R15490 T19903 T19902 dobj 8G3,clones
R15491 T19904 T19903 cc and,8G3
R15492 T19905 T19903 conj 1G6,8G3
R15493 T19906 T19905 punct ",",1G6
R15494 T19907 T19905 conj Ascenion,1G6
R15495 T19908 T19902 punct ),clones
R15496 T19909 T19910 auxpass were,used
R15497 T19910 T19919 ccomp used,followed
R15498 T19911 T19910 prep at,used
R15499 T19912 T19913 nummod 1:10,dilution
R15500 T19913 T19911 pobj dilution,at
R15501 T19914 T19913 prep from,dilution
R15502 T19915 T19916 compound tissue,culture
R15503 T19916 T19917 compound culture,supernatants
R15504 T19917 T19914 pobj supernatants,from
R15505 T19918 T19919 punct ",",followed
R15506 T19919 T19919 ROOT followed,followed
R15507 T19920 T19919 prep with,followed
R15508 T19921 T19922 nummod 8,μg
R15509 T19922 T19940 nmod μg,serum
R15510 T19923 T19924 compound /,ml
R15511 T19924 T19933 nmod ml,IgG
R15512 T19925 T19927 amod biotinylated,F
R15513 T19926 T19927 compound mouse,F
R15514 T19927 T19924 appos F,ml
R15515 T19928 T19929 punct (,ab
R15516 T19929 T19927 appos ab,F
R15517 T19930 T19929 punct ',ab
R15518 T19931 T19924 punct ),ml
R15519 T19932 T19933 amod anti-rat,IgG
R15520 T19933 T19922 appos IgG,μg
R15530 T19943 T19940 appos ImmunoResearch,serum
R15531 T19944 T19940 punct ),serum
R15532 T19945 T19940 cc and,serum
R15533 T19946 T19947 nummod 2,μg
R15534 T19947 T19940 conj μg,serum
R15535 T19948 T19952 nmod /,conjugate
R15536 T19949 T19952 nmod ml,conjugate
R15537 T19950 T19952 nmod streptavidin-alkaline,conjugate
R15538 T19951 T19952 compound phosphatase,conjugate
R15539 T19952 T19947 appos conjugate,μg
R15540 T19953 T19955 punct (,ImmunoResearch
R15541 T19954 T19955 compound Jackson,ImmunoResearch
R15542 T19955 T19952 appos ImmunoResearch,conjugate
R15543 T19956 T19955 punct ),ImmunoResearch
R15544 T19957 T19919 punct .,followed
R15545 T19958 T19960 nsubjpass Stains,developed
R15546 T19959 T19960 auxpass were,developed
R15547 T19960 T19960 ROOT developed,developed
R15548 T19961 T19960 prep with,developed
R15549 T19962 T19961 pobj BCIP/NBT,with
R15550 T19963 T19960 cc and,developed
R15551 T19964 T19960 conj counterstained,developed
R15552 T19965 T19964 prep in,counterstained
R15553 T19966 T19968 compound Nuclear,Red
R15554 T19967 T19968 compound Fast,Red
R15555 T19968 T19965 pobj Red,in
R15556 T19969 T19968 punct (,Red
R15557 T19970 T19968 appos Dako,Red
R15558 T19971 T19968 punct ),Red
R15559 T19972 T19960 punct .,developed
R15560 T19973 T19975 nsubjpass Phospho-Stat3,detected
R15561 T19974 T19975 auxpass was,detected
R15562 T19975 T19975 ROOT detected,detected
R15563 T19976 T19975 prep with,detected
R15564 T19977 T19978 nummod 4,μg
R15565 T19978 T19980 compound μg,ml
R15566 T19979 T19980 compound /,ml
R15567 T19980 T19976 pobj ml,with
R15568 T19981 T19980 prep of,ml
R15569 T19982 T19983 amod pStat3,antibody
R15570 T19983 T19981 pobj antibody,of
R15571 T19984 T19988 punct (,Signaling
R15572 T19985 T19988 npadvmod Tyr705,Signaling
R15573 T19986 T19988 punct ",",Signaling
R15574 T19987 T19988 compound Cell,Signaling
R15575 T19988 T19980 appos Signaling,ml
R15576 T19989 T19988 punct ),Signaling
R15577 T19990 T19975 cc and,detected
R15578 T19991 T19975 conj detected,detected
R15579 T19992 T19991 prep with,detected
R15580 T19993 T19997 amod anti-rabbit,kit
R15581 T19994 T19995 compound Poly-HRP,IHC
R15582 T19995 T19997 compound IHC,kit
R15583 T19996 T19997 compound detection,kit
R15584 T19997 T19992 pobj kit,with
R15585 T19998 T19997 punct (,kit
R15586 T19999 T19997 appos Chemicon,kit
R15587 T20000 T19997 punct ),kit
R15588 T20001 T19975 punct .,detected
R15716 T20169 T20170 compound Flow,cytometry
R15717 T20170 T20170 ROOT cytometry,cytometry
R15718 T20171 T20170 punct .,cytometry
R15719 T20172 T20173 compound One,million
R15720 T20173 T20174 nummod million,splenocytes
R15721 T20174 T20176 nsubjpass splenocytes,stained
R15722 T20175 T20176 auxpass were,stained
R15723 T20176 T20176 ROOT stained,stained
R15724 T20177 T20176 prep with,stained
R15725 T20178 T20182 det the,unconjugated
R15726 T20179 T20182 amod appropriate,unconjugated
R15727 T20180 T20182 amod primary,unconjugated
R15728 T20181 T20182 compound antibody,unconjugated
R15729 T20182 T20177 pobj unconjugated,with
R15730 T20183 T20182 cc or,unconjugated
R15731 T20184 T20182 conj conjugated,unconjugated
R15732 T20185 T20184 prep to,conjugated
R15733 T20186 T20185 pobj FITC,to
R15734 T20187 T20186 punct ",",FITC
R15735 T20188 T20186 conj PE,FITC
R15736 T20189 T20188 punct ",",PE
R15737 T20190 T20188 cc or,PE
R15738 T20191 T20188 conj APC,PE
R15739 T20192 T20184 conj diluted,conjugated
R15740 T20193 T20192 prep in,diluted
R15741 T20194 T20195 compound stain,buffer
R15742 T20195 T20193 pobj buffer,in
R15743 T20196 T20197 punct (,PBS
R15744 T20197 T20195 amod PBS,buffer
R15745 T20198 T20192 prep with,diluted
R15746 T20199 T20200 nummod 3,%
R15747 T20200 T20201 compound %,FBS
R15748 T20201 T20198 pobj FBS,with
R15749 T20202 T20176 punct ),stained
R15750 T20203 T20176 punct .,stained
R15751 T20204 T20213 prep For,used
R15752 T20205 T20206 compound BrdU,detection
R15753 T20206 T20204 pobj detection,For
R15754 T20207 T20213 punct ",",used
R15755 T20208 T20211 det the,kit
R15756 T20209 T20211 compound FITC-BrdU,kit
R15757 T20210 T20211 compound flow,kit
R15784 T20237 T20236 prep of,exclusion
R15785 T20238 T20239 amod dead,cells
R15786 T20239 T20237 pobj cells,of
R15787 T20240 T20236 punct ",",exclusion
R15788 T20241 T20228 conj stained,exposed
R15789 T20242 T20241 prep for,stained
R15790 T20243 T20244 compound surface,antigens
R15791 T20244 T20242 pobj antigens,for
R15792 T20245 T20244 punct ",",antigens
R15793 T20246 T20244 acl fixed,antigens
R15794 T20247 T20246 prep in,fixed
R15795 T20248 T20247 pobj paraformaldehyde,in
R15796 T20249 T20228 punct ",",exposed
R15797 T20250 T20228 cc and,exposed
R15798 T20251 T20228 conj permeabilized,exposed
R15799 T20252 T20251 prep with,permeabilized
R15800 T20253 T20252 pobj saponin,with
R15801 T20254 T20228 punct .,exposed
R15802 T20255 T20256 aux To,expose
R15803 T20256 T20262 advcl expose,treated
R15804 T20257 T20258 compound BrdU,epitopes
R15805 T20258 T20256 dobj epitopes,expose
R15806 T20259 T20262 punct ",",treated
R15807 T20260 T20262 nsubjpass cells,treated
R15808 T20261 T20262 auxpass were,treated
R15809 T20262 T20262 ROOT treated,treated
R15810 T20263 T20262 prep with,treated
R15811 T20264 T20263 pobj Dnase,with
R15815 T20268 T20270 amod FITC-conjugated,antibody
R15816 T20269 T20270 amod anti-BrdU,antibody
R15817 T20270 T20267 pobj antibody,with
R15842 T20295 T20296 nummod .2,program
R15843 T20296 T20291 pobj program,on
R15844 T20297 T20296 punct (,program
R15845 T20298 T20296 appos Dako,program
R15846 T20299 T20296 punct ),program
R15847 T20300 T20290 punct .,conducted
R16046 T20534 T20536 amod Rnase,assay
R16047 T20535 T20536 compound protection,assay
R16048 T20536 T20536 ROOT assay,assay
R16049 T20537 T20536 punct .,assay
R16050 T20538 T20539 amod Total,RNA
R16051 T20539 T20541 nsubjpass RNA,isolated
R16052 T20540 T20541 auxpass was,isolated
R16053 T20541 T20541 ROOT isolated,isolated
R16054 T20542 T20541 prep from,isolated
R16055 T20543 T20547 nummod CD19,cells
R16056 T20544 T20547 nummod +,cells
R16057 T20545 T20547 amod MACS-purified,cells
R16058 T20546 T20547 compound B,cells
R16059 T20547 T20542 pobj cells,from
R16060 T20548 T20541 advcl using,isolated
R16061 T20549 T20553 det the,kit
R16062 T20550 T20553 nmod Rneasy,kit
R16063 T20551 T20553 amod midi,kit
R16064 T20552 T20553 compound purification,kit
R16065 T20553 T20548 dobj kit,using
R16066 T20554 T20553 prep with,kit
R16067 T20555 T20556 compound Dnase,treatment
R16068 T20556 T20554 pobj treatment,with
R16069 T20557 T20541 punct ",",isolated
R16070 T20558 T20541 prep according,isolated
R16071 T20559 T20558 prep to,according
R16072 T20560 T20561 det the,manufacturer
R16073 T20561 T20563 poss manufacturer,instructions
R16074 T20562 T20561 case 's,manufacturer
R16075 T20563 T20559 pobj instructions,to
R16076 T20564 T20565 punct (,Qiagen
R16077 T20565 T20563 appos Qiagen,instructions
R16078 T20566 T20563 punct ),instructions
R16079 T20567 T20541 punct .,isolated
R16080 T20568 T20571 det The,template
R16081 T20569 T20571 amod mCK-1,template
R16082 T20570 T20571 compound probe,template
R16083 T20571 T20578 nsubjpass template,labeled
R16084 T20572 T20571 acl set,template
R16085 T20573 T20575 punct (,Biosciences
R16086 T20574 T20575 compound BD,Biosciences
R16087 T20575 T20572 appos Biosciences,set
R16088 T20576 T20572 punct ),set
R16089 T20577 T20578 auxpass was,labeled
R16090 T20578 T20578 ROOT labeled,labeled
R16091 T20579 T20578 advcl using,labeled
R16092 T20580 T20584 det the,Kit
R16093 T20581 T20584 compound In,Kit
R16094 T20582 T20583 compound Vitro,Transcription
R16095 T20583 T20584 compound Transcription,Kit
R16096 T20584 T20579 dobj Kit,using
R16097 T20585 T20578 prep according,labeled
R16098 T20586 T20585 prep to,according
R16099 T20587 T20588 det the,manufacturer
R16100 T20588 T20590 poss manufacturer,instructions
R16101 T20589 T20588 case 's,manufacturer
R16102 T20590 T20586 pobj instructions,to
R16103 T20591 T20593 punct (,Biosciences
R16104 T20592 T20593 compound BD,Biosciences
R16105 T20593 T20590 appos Biosciences,instructions
R16106 T20594 T20590 punct ),instructions
R16107 T20595 T20578 punct .,labeled
R16108 T20596 T20605 advmod Briefly,labeled
R16109 T20597 T20605 punct ",",labeled
R16110 T20598 T20599 nummod 50,ng
R16111 T20599 T20605 nsubjpass ng,labeled
R16112 T20600 T20599 prep of,ng
R16113 T20601 T20603 amod mCK-1,set
R16114 T20602 T20603 compound probe,set
R16115 T20603 T20600 pobj set,of
R16116 T20604 T20605 auxpass was,labeled
R16117 T20605 T20605 ROOT labeled,labeled
R16118 T20606 T20605 prep with,labeled
R16119 T20607 T20610 compound [,UTP
R16120 T20608 T20610 compound α-32P,UTP
R16121 T20609 T20610 compound ],UTP
R16122 T20610 T20606 pobj UTP,with
R16123 T20611 T20605 advcl using,labeled
R16124 T20612 T20614 nummod T7,polymerase
R16125 T20613 T20614 compound RNA,polymerase
R16126 T20614 T20611 dobj polymerase,using
R16127 T20615 T20605 cc and,labeled
R16128 T20616 T20605 conj purified,labeled
R16129 T20617 T20616 xcomp using,purified
R16130 T20618 T20619 compound Sephadex,G-50
R16131 T20619 T20620 compound G-50,columns
R16132 T20620 T20617 dobj columns,using
R16133 T20621 T20620 punct (,columns
R16134 T20622 T20623 compound NucAway,Spin
R16135 T20623 T20624 compound Spin,column
R16136 T20624 T20620 appos column,columns
R16137 T20625 T20624 punct ",",column
R16138 T20626 T20624 appos Ambion,column
R16139 T20627 T20624 punct ),column
R16140 T20628 T20605 punct .,labeled
R16141 T20629 T20631 det The,probe
R16142 T20630 T20631 amod labeled,probe
R16143 T20631 T20633 nsubjpass probe,quantitated
R16144 T20632 T20633 auxpass was,quantitated
R16145 T20633 T20633 ROOT quantitated,quantitated
R16146 T20634 T20633 advcl using,quantitated
R16147 T20635 T20636 det a,scintillation
R16148 T20636 T20634 dobj scintillation,using
R16149 T20637 T20634 advmod counter,using
R16150 T20638 T20634 punct ",",using
R16151 T20639 T20633 cc and,quantitated
R16152 T20640 T20644 nummod 6,cpm
R16153 T20641 T20644 nmod ×,cpm
R16154 T20642 T20641 nummod 105,×
R16155 T20643 T20644 compound cherenkov,cpm
R16156 T20644 T20646 nsubjpass cpm,used
R16157 T20645 T20646 auxpass was,used
R16158 T20646 T20633 conj used,quantitated
R16159 T20647 T20648 aux to,hybridize
R16160 T20648 T20646 xcomp hybridize,used
R16161 T20649 T20648 prep to,hybridize
R16162 T20650 T20651 nummod 4,μg
R16163 T20651 T20649 pobj μg,to
R16164 T20652 T20651 prep of,μg
R16165 T20653 T20654 amod total,RNA
R16166 T20654 T20652 pobj RNA,of
R16167 T20655 T20648 advcl using,hybridize
R16168 T20656 T20658 det the,kit
R16169 T20657 T20658 compound RPA,kit
R16170 T20658 T20655 dobj kit,using
R16171 T20659 T20658 punct (,kit
R16172 T20660 T20661 compound BD,Biosciences
R16173 T20661 T20658 appos Biosciences,kit
R16174 T20662 T20658 punct ),kit
R16175 T20663 T20646 punct .,used
R16176 T20664 T20666 nsubjpass Samples,denatured
R16177 T20665 T20666 auxpass were,denatured
R16178 T20666 T20666 ROOT denatured,denatured
R16179 T20667 T20666 prep at,denatured
R16180 T20668 T20669 nummod 90,°
R16181 T20669 T20667 pobj °,at
R16182 T20670 T20666 conj C,denatured
R16183 T20671 T20670 cc and,C
R16184 T20672 T20670 conj hybridized,C
R16185 T20673 T20672 prep at,hybridized
R16186 T20674 T20676 nummod 56,C
R16187 T20675 T20676 nummod °,C
R16188 T20676 T20677 compound C,overnight
R16189 T20677 T20673 pobj overnight,at
R16190 T20678 T20666 punct .,denatured
R16191 T20679 T20680 compound Single-stranded,RNA
R16192 T20680 T20682 nsubjpass RNA,digested
R16193 T20681 T20682 auxpass was,digested
R16194 T20682 T20682 ROOT digested,digested
R16195 T20683 T20682 prep with,digested
R16196 T20684 T20685 det a,mixture
R16197 T20685 T20683 pobj mixture,with
R16198 T20686 T20685 prep of,mixture
R16199 T20687 T20688 compound Rnase,A
R16200 T20688 T20686 pobj A,of
R16201 T20689 T20688 cc and,A
R16202 T20690 T20688 conj T1,A
R16203 T20691 T20690 punct ",",T1
R16204 T20692 T20682 cc and,digested
R16205 T20693 T20682 conj precipitated,digested
R16206 T20694 T20693 xcomp using,precipitated
R16207 T20695 T20694 dobj isopropanol,using
R16208 T20696 T20682 punct .,digested
R16209 T20697 T20698 amod Protected,probes
R16210 T20698 T20700 nsubjpass probes,resolved
R16211 T20699 T20700 auxpass were,resolved
R16212 T20700 T20700 ROOT resolved,resolved
R16213 T20701 T20700 prep on,resolved
R16214 T20702 T20707 det a,gel
R16215 T20703 T20707 amod denaturing,gel
R16216 T20704 T20705 nummod 4.75,%
R16217 T20705 T20707 compound %,gel
R16218 T20706 T20707 compound acrylamide,gel
R16219 T20707 T20701 pobj gel,on
R16220 T20708 T20709 punct ",",dried
R16221 T20709 T20700 conj dried,resolved
R16222 T20710 T20709 punct ",",dried
R16223 T20711 T20709 cc and,dried
R16224 T20712 T20709 conj imaged,dried
R16225 T20713 T20712 xcomp using,imaged
R16226 T20714 T20715 det a,phosphorImager
R16227 T20715 T20713 dobj phosphorImager,using
R16228 T20716 T20718 punct (,Dynamics
R16229 T20717 T20718 compound Molecular,Dynamics
R16230 T20718 T20715 appos Dynamics,phosphorImager
R16231 T20719 T20715 punct ),phosphorImager
R16232 T20720 T20709 punct .,dried
R16233 T20721 T20723 nsubjpass Densitometry,performed
R16234 T20722 T20723 auxpass was,performed
R16235 T20723 T20723 ROOT performed,performed
R16236 T20724 T20723 advcl using,performed
R16237 T20725 T20729 det the,software
R16238 T20726 T20729 nmod ImageQuant,software
R16239 T20727 T20729 nmod TL,software
R16240 T20728 T20729 nummod v2005,software
R16241 T20729 T20724 dobj software,using
R16242 T20730 T20729 punct (,software
R16243 T20731 T20732 compound GE,Healthcare
R16244 T20732 T20729 appos Healthcare,software
R16245 T20733 T20729 punct ),software
R16246 T20734 T20723 punct .,performed
R16359 T20886 T20887 compound PCR,analysis
R16360 T20887 T20887 ROOT analysis,analysis
R16361 T20888 T20887 prep of,analysis
R16362 T20889 T20891 compound κ,rearrangement
R16363 T20890 T20891 compound chain,rearrangement
R16364 T20891 T20888 pobj rearrangement,of
R16365 T20892 T20887 punct .,analysis
R16366 T20893 T20894 nsubj DNA,was
R16367 T20894 T20894 ROOT was,was
R16368 T20895 T20894 acomp isolated,was
R16369 T20896 T20895 prep from,isolated
R16370 T20897 T20896 pobj splenocytes,from
R16371 T20898 T20894 advcl using,was
R16372 T20899 T20902 det the,Kit
R16373 T20900 T20902 compound Dneasy,Kit
R16374 T20901 T20902 compound Tissue,Kit
R16375 T20902 T20898 dobj Kit,using
R16376 T20903 T20902 punct (,Kit
R16377 T20904 T20902 appos Qiagen,Kit
R16378 T20905 T20902 punct ),Kit
R16379 T20906 T20898 punct ",",using
R16380 T20907 T20898 prep with,using
R16381 T20908 T20909 compound Rnase,treatment
R16382 T20909 T20907 pobj treatment,with
R16383 T20910 T20894 punct .,was
R16384 T20911 T20912 compound PCR,reactions
R16385 T20912 T20913 nsubj reactions,contained
R16386 T20913 T20913 ROOT contained,contained
R16387 T20914 T20915 nummod 100,ng
R16388 T20915 T20913 dobj ng,contained
R16389 T20916 T20915 prep of,ng
R16390 T20917 T20918 amod genomic,DNA
R16391 T20918 T20916 pobj DNA,of
R16392 T20919 T20915 punct ",",ng
R16393 T20920 T20921 nummod 0.2,μM
R16394 T20921 T20915 appos μM,ng
R16395 T20922 T20923 det each,primer
R16396 T20923 T20915 conj primer,ng
R16397 T20924 T20923 punct ",",primer
R16398 T20925 T20927 nummod 0.2,dNTPs
R16399 T20926 T20927 compound mM,dNTPs
R16400 T20927 T20923 appos dNTPs,primer
R16401 T20928 T20927 punct ",",dNTPs
R16402 T20929 T20927 cc and,dNTPs
R16403 T20930 T20934 nummod 2.5,polymerase
R16404 T20931 T20934 compound U,polymerase
R16405 T20932 T20934 compound Taq,polymerase
R16406 T20933 T20934 compound DNA,polymerase
R16407 T20934 T20938 nsubj polymerase,performed
R16408 T20935 T20936 punct (,NEB
R16409 T20936 T20934 appos NEB,polymerase
R16410 T20937 T20934 punct ),polymerase
R16411 T20938 T20915 relcl performed,ng
R16412 T20939 T20938 prep in,performed
R16413 T20940 T20942 compound 1X,buffer
R16414 T20941 T20942 compound ThermoPol,buffer
R16415 T20942 T20939 pobj buffer,in
R16416 T20943 T20944 punct (,NEB
R16417 T20944 T20942 appos NEB,buffer
R16418 T20945 T20944 punct ),NEB
R16419 T20946 T20913 punct .,contained
R16420 T20947 T20949 nsubj Primers,were
R16421 T20948 T20947 acl used,Primers
R16422 T20949 T20949 ROOT were,were
R16423 T20950 T20949 attr Vκcon,were
R16424 T20951 T20950 cc and,Vκcon
R16425 T20952 T20950 conj Jκ5,Vκcon
R16426 T20953 T20950 nummod 1,Vκcon
R16427 T20954 T20950 appos °,Vκcon
R16428 T20955 T20949 cc and,were
R16429 T20956 T20958 aux have,described
R16430 T20957 T20958 auxpass been,described
R16431 T20958 T20949 conj described,were
R16432 T20959 T20962 advmod previously,]
R16433 T20960 T20962 nmod [,]
R16434 T20961 T20962 nummod 74,]
R16435 T20962 T20958 dobj ],described
R16436 T20963 T20958 punct .,described
R16437 T20964 T20965 compound PCR,conditions
R16438 T20965 T20966 nsubj conditions,were
R16439 T20966 T20966 ROOT were,were
R16440 T20967 T20968 nummod 94,°
R16441 T20968 T20969 compound °,C
R16442 T20969 T20966 attr C,were
R16443 T20970 T20969 prep for,C
R16444 T20971 T20972 nummod 2,min
R16445 T20972 T20970 pobj min,for
R16446 T20973 T20972 punct ",",min
R16447 T20974 T20975 nummod 40,cycles
R16448 T20975 T20972 appos cycles,min
R16449 T20976 T20975 prep of,cycles
R16450 T20977 T20978 compound 94,°
R16451 T20978 T20979 nummod °,C
R16452 T20979 T20976 pobj C,of
R16453 T20980 T20969 prep for,C
R16454 T20981 T20987 preconj 30,for
R16455 T20982 T20981 nmod s,30
R16456 T20983 T20982 punct ",",s
R16457 T20984 T20985 nummod 63,°
R16458 T20985 T20986 compound °,C
R16459 T20986 T20982 appos C,s
R16460 T20987 T20966 prep for,were
R16461 T20988 T20989 nummod 90,s
R16462 T20989 T20987 pobj s,for
R16463 T20990 T20987 punct ",",for
R16464 T20991 T20987 cc and,for
R16465 T20992 T20994 nummod 72,C
R16466 T20993 T20994 compound °,C
R16467 T20994 T20987 conj C,for
R16468 T20995 T20994 prep for,C
R16469 T20996 T20997 nummod 1,min
R16470 T20997 T20995 pobj min,for
R16471 T20998 T20994 punct ",",C
R16472 T20999 T20966 advcl followed,were
R16473 T21000 T20999 agent by,followed
R16474 T21001 T21002 nummod 1,cycle
R16475 T21002 T21000 pobj cycle,by
R16476 T21003 T21002 prep of,cycle
R16477 T21004 T21005 compound 72,°
R16478 T21005 T21006 nummod °,C
R16479 T21006 T21003 pobj C,of
R16480 T21007 T20999 prep for,followed
R16481 T21008 T21009 nummod 5,min
R16482 T21009 T21007 pobj min,for
R16483 T21010 T20966 punct .,were
R16646 T21195 T21196 compound Immunoblot,analysis
R16647 T21196 T21196 ROOT analysis,analysis
R16648 T21197 T21196 punct .,analysis
R16649 T21198 T21199 amod Whole,cell
R16650 T21199 T21200 compound cell,lysates
R16651 T21200 T21202 nsubjpass lysates,prepared
R16652 T21201 T21202 auxpass were,prepared
R16653 T21202 T21202 ROOT prepared,prepared
R16654 T21203 T21202 prep in,prepared
R16655 T21204 T21205 compound radioimmunoprecipitation,assay
R16656 T21205 T21203 pobj assay,in
R16657 T21206 T21205 punct (,assay
R16658 T21207 T21209 nmod RIPA,buffer
R16659 T21208 T21209 punct ),buffer
R16660 T21209 T21205 appos buffer,assay
R16661 T21210 T21215 punct (,pH
R16662 T21211 T21215 nummod 20,pH
R16663 T21212 T21215 compound mM,pH
R16664 T21213 T21215 compound Tris-HCl,pH
R16665 T21214 T21215 compound [,pH
R16666 T21215 T21217 nmod pH,]
R16667 T21216 T21217 nummod 7.5,]
R16668 T21217 T21209 appos ],buffer
R16669 T21218 T21217 punct ",",]
R16670 T21219 T21221 nummod 150,NaCl
R16671 T21220 T21221 compound mM,NaCl
R16672 T21221 T21217 appos NaCl,]
R16673 T21222 T21221 punct ",",NaCl
R16674 T21223 T21225 nummod 1,EDTA
R16675 T21224 T21225 compound mM,EDTA
R16676 T21225 T21221 appos EDTA,NaCl
R16677 T21226 T21225 punct ",",EDTA
R16678 T21227 T21228 nummod 1,%
R16679 T21228 T21229 compound %,NP-40
R16680 T21229 T21225 appos NP-40,EDTA
R16681 T21230 T21229 punct ",",NP-40
R16682 T21231 T21232 nummod 0.1,%
R16683 T21232 T21233 compound %,SDS
R16684 T21233 T21217 appos SDS,]
R16685 T21234 T21233 punct ",",SDS
R16686 T21235 T21236 nummod 0.1,%
R16687 T21236 T21238 nmod %,deoxycholate
R16688 T21237 T21238 compound sodium,deoxycholate
R16689 T21238 T21233 appos deoxycholate,SDS
R16690 T21239 T21205 punct ),assay
R16691 T21240 T21202 conj supplemented,prepared
R16692 T21241 T21240 prep with,supplemented
R16693 T21242 T21245 nummod 2,fluoride
R16694 T21243 T21245 nmod mM,fluoride
R16695 T21244 T21245 compound phenylmethylsulfonyl,fluoride
R16696 T21245 T21241 pobj fluoride,with
R16697 T21246 T21245 punct ",",fluoride
R16698 T21247 T21249 nummod 1,Na3VO4
R16699 T21248 T21249 compound mM,Na3VO4
R16700 T21249 T21245 appos Na3VO4,fluoride
R16701 T21250 T21249 punct ",",Na3VO4
R16702 T21251 T21249 cc and,Na3VO4
R16703 T21252 T21255 nummod 1:100,cocktails
R16704 T21253 T21255 amod protease/phosphatase,cocktails
R16705 T21254 T21255 compound inhibitor,cocktails
R16706 T21255 T21249 conj cocktails,Na3VO4
R16707 T21256 T21255 punct (,cocktails
R16708 T21257 T21255 appos Sigma,cocktails
R16709 T21258 T21255 punct ),cocktails
R16710 T21259 T21202 punct .,prepared
R16711 T21260 T21261 amod Crude,lysates
R16712 T21261 T21263 nsubjpass lysates,centrifuged
R16713 T21262 T21263 auxpass were,centrifuged
R16714 T21263 T21263 ROOT centrifuged,centrifuged
R16715 T21264 T21263 prep at,centrifuged
R16716 T21265 T21266 nummod "13,000",rpm
R16717 T21266 T21264 pobj rpm,at
R16718 T21267 T21263 prep for,centrifuged
R16719 T21268 T21269 nummod 10,min
R16720 T21269 T21267 pobj min,for
R16721 T21270 T21263 prep at,centrifuged
R16722 T21271 T21272 nummod 4,°
R16723 T21272 T21273 nummod °,C
R16724 T21273 T21270 pobj C,at
R16725 T21274 T21273 cc and,C
R16726 T21275 T21276 det the,supernatants
R16727 T21276 T21273 conj supernatants,C
R16728 T21277 T21278 auxpass were,collected
R16729 T21278 T21263 conj collected,centrifuged
R16730 T21279 T21278 prep for,collected
R16731 T21280 T21281 amod further,analysis
R16732 T21281 T21279 pobj analysis,for
R16733 T21282 T21263 punct .,centrifuged
R16734 T21283 T21284 compound Protein,concentrations
R16735 T21284 T21286 nsubjpass concentrations,determined
R16736 T21285 T21286 auxpass were,determined
R16748 T21297 T21297 ROOT boiled,boiled
R16749 T21298 T21297 prep in,boiled
R16750 T21299 T21300 det the,presence
R16751 T21300 T21298 pobj presence,in
R16752 T21301 T21300 prep of,presence
R16753 T21302 T21303 nummod 2.5,%
R16754 T21303 T21304 compound %,β-mecaptoethanol
R16755 T21304 T21301 pobj β-mecaptoethanol,of
R16756 T21305 T21304 punct ",",β-mecaptoethanol
R16757 T21306 T21300 acl separated,presence
R16758 T21307 T21306 agent by,separated
R16759 T21308 T21309 compound denaturing,SDS-PAGE
R16760 T21309 T21307 pobj SDS-PAGE,by
R16761 T21310 T21297 punct ",",boiled
R16762 T21311 T21297 cc and,boiled
R16763 T21312 T21297 conj transferred,boiled
R16764 T21313 T21312 prep to,transferred
R16765 T21314 T21316 dep 0.45,μm
R16766 T21315 T21316 punct -,μm
R16767 T21316 T21318 compound μm,membranes
R16768 T21317 T21318 compound Optitran,membranes
R16769 T21318 T21313 pobj membranes,to
R16770 T21319 T21318 punct (,membranes
R16771 T21320 T21318 appos Schleicher,membranes
R16772 T21321 T21320 cc &,Schleicher
R16773 T21322 T21320 conj Schuell,Schleicher
R16774 T21323 T21318 punct ),membranes
R16775 T21324 T21312 prep in,transferred
R16776 T21325 T21328 det a,unit
R16777 T21326 T21328 compound Bio-Rad,unit
R16778 T21327 T21328 compound transfer,unit
R16779 T21328 T21324 pobj unit,in
R16780 T21329 T21297 punct .,boiled
R16781 T21330 T21332 nsubjpass Membranes,immunoblotted
R16782 T21331 T21332 auxpass were,immunoblotted
R16783 T21332 T21342 ccomp immunoblotted,tagged
R16784 T21333 T21332 prep with,immunoblotted
R16785 T21334 T21337 det the,antibody
R16786 T21335 T21337 amod appropriate,antibody
R16787 T21336 T21337 amod primary,antibody
R16788 T21337 T21333 pobj antibody,with
R16789 T21338 T21337 acl followed,antibody
R16790 T21339 T21338 agent by,followed
R16791 T21340 T21341 compound horseradish,peroxidase
R16792 T21341 T21339 pobj peroxidase,by
R16793 T21342 T21342 ROOT tagged,tagged
R16794 T21343 T21344 amod secondary,antibodies
R16795 T21344 T21342 dobj antibodies,tagged
R16796 T21345 T21352 punct (,detected
R16797 T21346 T21347 compound Amersham,Biosciences
R16798 T21347 T21352 nsubj Biosciences,detected
R16799 T21348 T21347 cc and,Biosciences
R16800 T21349 T21347 conj Dako,Biosciences
R16801 T21350 T21349 punct ),Dako
R16802 T21351 T21347 cc and,Biosciences
R16803 T21352 T21342 parataxis detected,tagged
R16804 T21353 T21352 prep with,detected
R16805 T21354 T21358 det the,System
R16806 T21355 T21358 compound SuperSignal,System
R16807 T21356 T21358 compound West,System
R16808 T21357 T21358 compound Pico,System
R16809 T21358 T21353 pobj System,with
R16810 T21359 T21358 punct (,System
R16811 T21360 T21358 appos Pierce,System
R16812 T21361 T21358 punct ),System
R16813 T21362 T21342 punct .,tagged
R16814 T21474 T21474 ROOT Antibodies,Antibodies
R16815 T21475 T21474 punct .,Antibodies
R16816 T21476 T21477 amod FITC-conjugated,goat
R16817 T21477 T21479 compound goat,IgM
R16818 T21478 T21479 compound anti-mouse,IgM
R16819 T21479 T21479 ROOT IgM,IgM
R16820 T21480 T21479 punct ",",IgM
R16821 T21481 T21484 compound rat,IgD
R16822 T21482 T21484 compound IgG2aκ,IgD
R16823 T21483 T21484 compound anti-mouse,IgD
R16824 T21484 T21479 appos IgD,IgM
R16825 T21485 T21486 punct (,clone
R16832 T21492 T21494 nmod IgG1κ,kappa
R16833 T21493 T21494 compound anti-mouse,kappa
R16834 T21494 T21486 appos kappa,clone
R16835 T21495 T21496 punct (,clone
R16836 T21496 T21494 appos clone,kappa
R16837 T21497 T21496 nummod 187.1,clone
R16838 T21498 T21496 punct ),clone
R16839 T21499 T21494 punct ",",kappa
R16840 T21500 T21510 npadvmod rat,PE-conjugated
R16841 T21501 T21503 nmod IgG2bκ,lambda
R16842 T21502 T21503 amod anti-mouse,lambda
R16843 T21503 T21510 ccomp lambda,PE-conjugated
R16844 T21504 T21506 punct (,JC5
R16845 T21505 T21506 compound clone,JC5
R16846 T21506 T21503 appos JC5,lambda
R16847 T21507 T21510 meta 1,PE-conjugated
R16848 T21508 T21507 punct ),1
R16849 T21509 T21510 punct ;,PE-conjugated
R16850 T21510 T21510 ROOT PE-conjugated,PE-conjugated
R16851 T21511 T21512 compound goat,anti-mouse
R16852 T21512 T21513 advmod anti-mouse,IgG
R16853 T21513 T21510 dobj IgG,PE-conjugated
R16854 T21514 T21513 punct ;,IgG
R16855 T21515 T21518 amod un-conjugated,kappa
R16856 T21516 T21518 compound goat,kappa
R16857 T21517 T21518 compound anti-mouse,kappa
R16858 T21518 T21513 appos kappa,IgG
R16859 T21519 T21518 cc and,kappa
R16860 T21520 T21518 conj anti-mouse,kappa
R16861 T21521 T21523 nsubjpass lambda,purchased
R16862 T21522 T21523 auxpass were,purchased
R16863 T21523 T21510 conj purchased,PE-conjugated
R16864 T21524 T21523 prep from,purchased
R16865 T21525 T21526 compound Southern,Biotech
R16866 T21526 T21524 pobj Biotech,from
R16867 T21527 T21510 punct .,PE-conjugated
R16868 T21528 T21529 amod APC-conjugated,rat
R16869 T21529 T21532 compound rat,CD19
R16870 T21530 T21532 compound IgG2aκ,CD19
R16871 T21531 T21532 compound anti-mouse,CD19
R16872 T21532 T21532 ROOT CD19,CD19
R16873 T21533 T21534 punct (,clone
R16874 T21534 T21535 compound clone,6D5
R16875 T21535 T21532 appos 6D5,CD19
R16876 T21536 T21532 punct ),CD19
R16877 T21537 T21532 punct ",",CD19
R16878 T21538 T21539 amod PE-conjugated,mouse
R16879 T21539 T21541 compound mouse,anti-LMP1
R16880 T21540 T21541 compound IgG2aκ,anti-LMP1
R16881 T21541 T21532 conj anti-LMP1,CD19
R16882 T21542 T21543 punct (,clone
R16883 T21543 T21544 compound clone,S12
R16884 T21544 T21541 appos S12,anti-LMP1
R16885 T21545 T21541 punct ),anti-LMP1
R16886 T21546 T21541 punct ",",anti-LMP1
R16887 T21547 T21548 amod un-conjugated,mouse
R16888 T21548 T21550 compound mouse,anti-Rb
R16889 T21549 T21550 compound IgG2a,anti-Rb
R16890 T21550 T21541 conj anti-Rb,anti-LMP1
R16891 T21551 T21552 punct (,clone
R16892 T21552 T21550 parataxis clone,anti-Rb
R16893 T21553 T21552 nummod 2,clone
R16894 T21554 T21553 punct ),2
R16895 T21555 T21552 punct ",",clone
R16896 T21556 T21552 cc and,clone
R16897 T21557 T21552 conj anti-Cdk2,clone
R16898 T21558 T21563 punct (,purchased
R16899 T21559 T21561 nmod clone,)
R16900 T21560 T21559 nummod 55,clone
R16901 T21561 T21563 punct ),purchased
R16902 T21562 T21563 auxpass were,purchased
R16903 T21563 T21563 ROOT purchased,purchased
R16904 T21564 T21563 prep from,purchased
R16905 T21565 T21566 compound BD,Bioscience
R16906 T21566 T21564 pobj Bioscience,from
R16907 T21567 T21563 punct .,purchased
R16908 T21568 T21569 amod PE-conjugated,rat
R16909 T21569 T21572 nmod rat,CD5
R16910 T21570 T21572 nmod IgG2aκ,CD5
R16911 T21571 T21572 compound anti-mouse,CD5
R16912 T21572 T21579 nsubjpass CD5,purchased
R16913 T21573 T21574 punct (,clone
R16914 T21574 T21572 appos clone,CD5
R16915 T21575 T21574 nummod 53,clone
R16916 T21576 T21574 appos 7.3,clone
R16917 T21577 T21574 punct ),clone
R16918 T21578 T21579 auxpass was,purchased
R16919 T21579 T21579 ROOT purchased,purchased
R16920 T21580 T21579 prep from,purchased
R16921 T21581 T21580 pobj eBioscience,from
R16922 T21582 T21579 punct .,purchased
R16923 T21583 T21584 compound Rat,anti-LMP1
R16924 T21584 T21597 nsubjpass anti-LMP1,purchased
R16925 T21585 T21597 punct (,purchased
R16926 T21586 T21597 nsubjpass clones,purchased
R16927 T21587 T21586 dobj 8G3,clones
R16928 T21588 T21587 punct ",",8G3
R16929 T21589 T21587 conj 1G6,8G3
R16930 T21590 T21589 punct ",",1G6
R16931 T21591 T21589 conj 7E10,1G6
R16932 T21592 T21591 punct ",",7E10
R16933 T21593 T21591 cc and,7E10
R16934 T21594 T21591 conj 7G8,7E10
R16935 T21595 T21597 punct ),purchased
R16936 T21596 T21597 auxpass was,purchased
R16937 T21597 T21597 ROOT purchased,purchased
R16938 T21598 T21597 prep from,purchased
R16939 T21599 T21598 pobj Ascenion,from
R16940 T21600 T21597 punct .,purchased
R16941 T21601 T21602 compound Rabbit,anti-pAkt
R16942 T21602 T21638 nsubj anti-pAkt,purchased
R16943 T21603 T21609 punct (,β
R16944 T21604 T21609 amod Ser473,β
R16945 T21605 T21604 punct ),Ser473
R16946 T21606 T21609 punct ",",β
R16947 T21607 T21609 amod anti-pGSK3α,β
R16948 T21608 T21609 compound /,β
R16949 T21609 T21602 appos β,anti-pAkt
R16950 T21610 T21609 punct (,β
R16951 T21611 T21609 appos Ser21/9,β
R16952 T21612 T21609 punct ),β
R16953 T21613 T21609 punct ",",β
R16954 T21614 T21638 nmod anti-pStat3,purchased
R16955 T21615 T21616 punct (,Tyr705
R16956 T21616 T21614 appos Tyr705,anti-pStat3
R16957 T21617 T21614 punct ),anti-pStat3
R16958 T21618 T21614 punct ",",anti-pStat3
R16959 T21619 T21614 conj anti-pStat6,anti-pStat3
R16960 T21620 T21619 punct (,anti-pStat6
R16961 T21621 T21619 appos Tyr641,anti-pStat6
R16962 T21622 T21619 punct ),anti-pStat6
R16963 T21623 T21619 punct ",",anti-pStat6
R16964 T21624 T21614 appos anti-pmTOR,anti-pStat3
R16965 T21625 T21624 punct (,anti-pmTOR
R16966 T21626 T21624 appos Ser2448,anti-pmTOR
R16967 T21627 T21624 punct ),anti-pmTOR
R16968 T21628 T21624 punct ",",anti-pmTOR
R16969 T21629 T21638 amod anti-Stat6,purchased
R16970 T21630 T21629 punct ",",anti-Stat6
R16971 T21631 T21638 nsubjpass anti-Akt,purchased
R16972 T21632 T21631 punct ",",anti-Akt
R16973 T21633 T21631 conj anti-FoxO1,anti-Akt
R16974 T21634 T21633 punct ",",anti-FoxO1
R16975 T21635 T21633 cc and,anti-FoxO1
R16976 T21636 T21633 conj anti-p27,anti-FoxO1
R16977 T21637 T21638 auxpass were,purchased
R16978 T21638 T21638 ROOT purchased,purchased
R16979 T21639 T21638 prep from,purchased
R16980 T21640 T21641 compound Cell,Signaling
R16981 T21641 T21639 pobj Signaling,from
R16982 T21642 T21638 punct .,purchased
R16983 T21643 T21644 compound Rabbit,anti-Stat3
R16984 T21644 T21662 nsubjpass anti-Stat3,purchased
R16985 T21645 T21646 punct (,H-190
R16986 T21646 T21644 appos H-190,anti-Stat3
R16987 T21647 T21646 punct ),H-190
R16988 T21648 T21644 punct ",",anti-Stat3
R16989 T21649 T21662 nsubjpass anti-IκBα,purchased
R16990 T21650 T21651 punct (,C-21
R16991 T21651 T21649 appos C-21,anti-IκBα
R16992 T21652 T21651 punct ),C-21
R16993 T21653 T21649 punct ",",anti-IκBα
R16994 T21654 T21649 cc and,anti-IκBα
R16995 T21655 T21657 nmod goat,actin
R16996 T21656 T21657 amod anti-β,actin
R16997 T21657 T21649 conj actin,anti-IκBα
R16998 T21658 T21659 punct (,I-19
R16999 T21659 T21657 appos I-19,actin
R17000 T21660 T21657 punct ),actin
R17001 T21661 T21662 auxpass were,purchased
R17002 T21662 T21662 ROOT purchased,purchased
R17003 T21663 T21662 prep from,purchased
R17004 T21664 T21665 compound Santa,Cruz
R17005 T21665 T21666 compound Cruz,Biotechnology
R17006 T21666 T21663 pobj Biotechnology,from
R17007 T21667 T21662 punct .,purchased
R17008 T21668 T21670 compound Mouse,anti-GSK3
R17009 T21669 T21670 compound IgG1κ,anti-GSK3
R17010 T21670 T21672 nsubjpass anti-GSK3,purchased
R17011 T21671 T21672 auxpass was,purchased
R17012 T21672 T21672 ROOT purchased,purchased
R17013 T21673 T21672 prep from,purchased
R17014 T21674 T21675 compound Upstate,Biotechnology
R17015 T21675 T21673 pobj Biotechnology,from
R17016 T21676 T21672 punct .,purchased
R17017 T21677 T21678 compound Rabbit,anti-pRb
R17018 T21678 T21678 ROOT anti-pRb,anti-pRb
R17019 T21679 T21683 punct (,purchased
R17020 T21680 T21683 nsubjpass Thr373,purchased
R17021 T21681 T21680 punct ),Thr373
R17022 T21682 T21683 auxpass was,purchased
R17023 T21683 T21683 ROOT purchased,purchased
R17024 T21684 T21683 prep from,purchased
R17025 T21685 T21686 compound EMD,Biosciences
R17026 T21686 T21684 pobj Biosciences,from
R17027 T21687 T21683 punct .,purchased
R17037 T21815 T21817 compound High,Expression
R17038 T21816 T21817 compound LMP1,Expression
R17039 T21817 T21818 compound Expression,Correlates
R17040 T21818 T21827 nsubjpass Correlates,shown
R17041 T21819 T21818 prep with,Correlates
R17042 T21820 T21821 det the,Development
R17043 T21821 T21819 pobj Development,with
R17044 T21822 T21821 prep of,Development
R17045 T21823 T21824 compound Lymphoma,LMP1
R17046 T21824 T21825 compound LMP1,expression
R17047 T21825 T21822 pobj expression,of
R17048 T21826 T21827 auxpass is,shown
R17049 T21827 T21827 ROOT shown,shown
R17050 T21828 T21827 agent by,shown
R17051 T21829 T21830 punct (,A
R17052 T21830 T21828 pobj A,by
R17053 T21831 T21830 punct ),A
R17054 T21832 T21827 npadvmod immunoblotting,shown
R17055 T21833 T21832 prep of,immunoblotting
R17056 T21834 T21836 amod purified,cells
R17057 T21835 T21836 compound B,cells
R17058 T21836 T21833 pobj cells,of
R17059 T21837 T21836 punct (,cells
R17060 T21838 T21839 nummod CD19,+
R17061 T21839 T21836 appos +,cells
R17062 T21840 T21836 punct ),cells
R17063 T21841 T21832 cc and,immunoblotting
R17064 T21842 T21843 punct (,B
R17065 T21843 T21846 nmod B,staining
R17066 T21844 T21843 punct ),B
R17067 T21845 T21846 compound immunohistochemistry,staining
R17068 T21846 T21832 conj staining,immunoblotting
R17069 T21847 T21846 prep of,staining
R17070 T21848 T21849 amod spleen,tissue
R17071 T21849 T21847 pobj tissue,of
R17072 T21850 T21849 prep from,tissue
R17073 T21851 T21850 pobj wild-type,from
R17074 T21852 T21851 punct (,wild-type
R17075 T21853 T21851 appos WT,wild-type
R17076 T21854 T21853 punct ),WT
R17077 T21855 T21851 cc and,wild-type
R17078 T21856 T21858 nummod LMP1,mice
R17079 T21857 T21858 amod transgenic,mice
R17080 T21858 T21851 conj mice,wild-type
R17081 T21859 T21827 punct .,shown
R17082 T21860 T21863 punct (,Lymphomas
R17083 T21861 T21863 nmod A,Lymphomas
R17084 T21862 T21863 punct ),Lymphomas
R17085 T21863 T21865 nsubjpass Lymphomas,identified
R17086 T21864 T21865 auxpass are,identified
R17087 T21865 T21865 ROOT identified,identified
R17088 T21866 T21865 prep with,identified
R17089 T21867 T21868 det a,number
R17090 T21868 T21866 pobj number,with
R17091 T21869 T21868 punct (,number
R17092 T21870 T21868 nummod 1,number
R17093 T21871 T21868 nummod 7,number
R17094 T21872 T21868 punct ),number
R17095 T21873 T21865 punct .,identified
R17096 T21874 T21875 nsubj Arrows,indicate
R17097 T21875 T21875 ROOT indicate,indicate
R17098 T21876 T21878 det the,band
R17099 T21877 T21878 amod LMP1-specific,band
R17100 T21878 T21875 dobj band,indicate
R17101 T21879 T21878 cc and,band
R17102 T21880 T21882 poss its,products
R17103 T21881 T21882 compound degradation,products
R17104 T21882 T21878 conj products,band
R17105 T21883 T21885 advmod as,as
R17106 T21884 T21885 advmod well,as
R17107 T21885 T21882 cc as,products
R17108 T21886 T21888 det a,band
R17109 T21887 T21888 amod non-specific,band
R17110 T21888 T21882 conj band,products
R17111 T21889 T21875 punct .,indicate
R17112 T21890 T21892 nsubjpass Actin,used
R17113 T21891 T21892 auxpass was,used
R17114 T21892 T21892 ROOT used,used
R17115 T21893 T21892 prep as,used
R17116 T21894 T21896 det a,control
R17117 T21895 T21896 compound loading,control
R17118 T21896 T21893 pobj control,as
R17119 T21897 T21892 punct .,used
R17120 T21898 T21901 punct (,White
R17121 T21899 T21901 nmod B,White
R17122 T21900 T21901 punct ),White
R17123 T21901 T21906 nsubjpass White,shown
R17124 T21902 T21901 cc and,White
R17125 T21903 T21904 amod red,pulps
R17126 T21904 T21901 conj pulps,White
R17127 T21905 T21906 auxpass are,shown
R17128 T21906 T21906 ROOT shown,shown
R17129 T21907 T21906 punct ",",shown
R17130 T21908 T21906 cc but,shown
R17131 T21909 T21910 det this,architecture
R17132 T21910 T21912 nsubjpass architecture,lost
R17133 T21911 T21912 auxpass is,lost
R17134 T21912 T21906 conj lost,shown
R17135 T21913 T21912 prep upon,lost
R17136 T21914 T21913 pobj development,upon
R17137 T21915 T21914 prep of,development
R17138 T21916 T21915 pobj lymphoma,of
R17139 T21917 T21912 punct .,lost
R17140 T21918 T21919 compound Scale,bar
R17141 T21919 T21919 ROOT bar,bar
R17142 T21920 T21919 punct ",",bar
R17143 T21921 T21922 nummod 20,μm
R17144 T21922 T21919 appos μm,bar
R17145 T21923 T21919 punct .,bar
R17461 T22333 T22336 nummod LMP1,Lymphomas
R17462 T22334 T22336 compound Promotes,Lymphomas
R17463 T22335 T22336 compound B-1a,Lymphomas
R17464 T22336 T22336 ROOT Lymphomas,Lymphomas
R17465 T22337 T22339 nsubj That,Escape
R17466 T22338 T22339 aux Can,Escape
R17467 T22339 T22336 relcl Escape,Lymphomas
R17468 T22340 T22341 compound Allelic,Exclusion
R17469 T22341 T22339 dobj Exclusion,Escape
R17470 T22342 T22341 punct (,Exclusion
R17471 T22343 T22341 appos A,Exclusion
R17472 T22344 T22343 punct ),A
R17473 T22345 T22347 compound Flow,analysis
R17474 T22346 T22347 compound cytometry,analysis
R17475 T22347 T22389 nmod analysis,markers
R17476 T22348 T22347 prep of,analysis
R17477 T22349 T22348 pobj splenocytes,of
R17478 T22350 T22349 prep from,splenocytes
R17479 T22351 T22352 det a,WT
R17480 T22352 T22350 pobj WT,from
R17481 T22353 T22352 cc or,WT
R17482 T22354 T22352 conj LMP1,WT
R17483 T22355 T22356 amod transgenic,lymphoma
R17484 T22356 T22347 appos lymphoma,analysis
R17485 T22357 T22356 prep for,lymphoma
R17486 T22358 T22359 det the,pan
R17487 T22359 T22357 pobj pan,for
R17488 T22360 T22361 compound B,cell
R17489 T22361 T22347 appos cell,analysis
R17490 T22362 T22361 punct (,cell
R17491 T22363 T22361 appos CD19,cell
R17492 T22364 T22361 punct ),cell
R17493 T22365 T22361 punct ",",cell
R17494 T22366 T22367 amod B-1a,cell
R17495 T22367 T22347 appos cell,analysis
R17496 T22368 T22367 punct (,cell
R17497 T22369 T22367 appos CD5,cell
R17498 T22370 T22367 punct ),cell
R17499 T22371 T22347 punct ",",analysis
R17500 T22372 T22347 cc and,analysis
R17501 T22373 T22375 nmod Ig,chain
R17502 T22374 T22375 amod heavy,chain
R17503 T22375 T22347 conj chain,analysis
R17504 T22376 T22375 punct (,chain
R17505 T22377 T22375 appos IgM,chain
R17506 T22378 T22377 cc and,IgM
R17507 T22379 T22377 conj IgD,IgM
R17508 T22380 T22375 punct ),chain
R17509 T22381 T22375 cc and,chain
R17510 T22382 T22383 amod light,chain
R17511 T22383 T22347 appos chain,analysis
R17512 T22384 T22385 punct (,κ
R17513 T22385 T22389 nmod κ,markers
R17514 T22386 T22385 cc and,κ
R17515 T22387 T22385 conj λ,κ
R17516 T22388 T22387 punct ),λ
R17517 T22389 T22389 ROOT markers,markers
R17518 T22390 T22389 punct .,markers
R17519 T22391 T22391 ROOT Shown,Shown
R17520 T22392 T22391 auxpass are,Shown
R17521 T22393 T22394 det the,results
R17522 T22394 T22391 nsubjpass results,Shown
R17523 T22395 T22394 prep from,results
R17524 T22396 T22397 compound WT,lymphoma
R17525 T22397 T22395 pobj lymphoma,from
R17526 T22398 T22397 nummod 1,lymphoma
R17527 T22399 T22397 cc and,lymphoma
R17528 T22400 T22402 nummod LMP1,lymphoma
R17529 T22401 T22402 amod transgenic,lymphoma
R17530 T22402 T22397 conj lymphoma,lymphoma
R17531 T22403 T22402 nummod 4,lymphoma
R17532 T22404 T22391 punct .,Shown
R17533 T22405 T22406 det This,analysis
R17534 T22406 T22408 nsubjpass analysis,repeated
R17535 T22407 T22408 auxpass was,repeated
R17536 T22408 T22408 ROOT repeated,repeated
R17537 T22409 T22408 prep on,repeated
R17538 T22410 T22414 nummod four,lymphomas
R17539 T22411 T22414 amod other,lymphomas
R17540 T22412 T22414 compound LMP1,lymphomas
R17541 T22413 T22414 compound transgenic,lymphomas
R17542 T22414 T22409 pobj lymphomas,on
R17543 T22415 T22414 punct (,lymphomas
R17544 T22416 T22414 appos 1,lymphomas
R17545 T22417 T22414 punct ",",lymphomas
R17546 T22418 T22414 appos 2,lymphomas
R17547 T22419 T22418 punct ",",2
R17548 T22420 T22418 conj 3,2
R17549 T22421 T22414 punct ",",lymphomas
R17550 T22422 T22414 cc and,lymphomas
R17551 T22423 T22433 dep 6,lymphomas
R17552 T22424 T22423 punct ),6
R17553 T22425 T22423 acl showing,6
R17554 T22426 T22429 det a,phenotype
R17555 T22427 T22429 amod similar,phenotype
R17556 T22428 T22429 compound B-1a,phenotype
R17557 T22429 T22425 dobj phenotype,showing
R17558 T22430 T22429 punct ",",phenotype
R17559 T22431 T22433 prep of,lymphomas
R17560 T22432 T22431 pobj which,of
R17561 T22433 T22414 conj lymphomas,lymphomas
R17562 T22434 T22433 dobj 2,lymphomas
R17563 T22435 T22434 cc and,2
R17564 T22436 T22434 conj 4,2
R17565 T22437 T22408 auxpass were,repeated
R17566 T22438 T22437 advmod also,were
R17567 T22439 T22440 advmod doubly,positive
R17568 T22440 T22437 acomp positive,were
R17569 T22441 T22440 prep for,positive
R17570 T22442 T22446 nmod κ,chains
R17571 T22443 T22442 cc and,κ
R17572 T22444 T22446 compound λ,chains
R17573 T22445 T22446 compound light,chains
R17574 T22446 T22441 pobj chains,for
R17575 T22447 T22437 punct .,were
R17576 T22448 T22449 punct (,B
R17577 T22449 T22449 ROOT B,B
R17578 T22450 T22449 punct ),B
R17579 T22451 T22453 compound Flow,analysis
R17580 T22452 T22453 compound cytometry,analysis
R17581 T22453 T22453 ROOT analysis,analysis
R17582 T22454 T22453 prep of,analysis
R17583 T22455 T22454 pobj WT,of
R17584 T22456 T22455 cc or,WT
R17585 T22457 T22455 conj LMP1,WT
R17586 T22458 T22459 amod transgenic,splenocytes
R17587 T22459 T22453 conj splenocytes,analysis
R17588 T22460 T22459 prep for,splenocytes
R17589 T22461 T22460 pobj B-1a,for
R17590 T22462 T22461 punct (,B-1a
R17591 T22463 T22461 nummod CD19,B-1a
R17592 T22464 T22461 conj +,B-1a
R17593 T22465 T22464 nummod CD5,+
R17594 T22466 T22464 appos +,+
R17595 T22467 T22464 punct ),+
R17596 T22468 T22461 cc and,B-1a
R17597 T22469 T22461 conj B-1b,B-1a
R17598 T22470 T22469 cc or,B-1b
R17599 T22471 T22469 conj B2,B-1b
R17600 T22472 T22469 conj subsets,B-1b
R17601 T22473 T22472 punct (,subsets
R17602 T22474 T22475 nummod CD19,+
R17603 T22475 T22472 appos +,subsets
R17604 T22476 T22477 nummod CD5,−
R17605 T22477 T22475 appos −,+
R17606 T22478 T22475 punct ),+
R17607 T22479 T22472 punct .,subsets
R17608 T22480 T22489 nsubjpass Percentages,shown
R17609 T22481 T22480 prep of,Percentages
R17610 T22482 T22481 pobj B-1a,of
R17611 T22483 T22482 cc and,B-1a
R17612 T22484 T22482 conj B-1b,B-1a
R17613 T22485 T22484 cc or,B-1b
R17614 T22486 T22484 conj B2,B-1b
R17615 T22487 T22481 pobj subsets,of
R17616 T22488 T22489 auxpass are,shown
R17617 T22489 T22489 ROOT shown,shown
R17618 T22490 T22489 prep in,shown
R17619 T22491 T22492 det each,quadrant
R17620 T22492 T22490 pobj quadrant,in
R17621 T22493 T22489 punct .,shown
R17622 T22494 T22495 det This,analysis
R17623 T22495 T22497 nsubjpass analysis,repeated
R17624 T22496 T22497 auxpass was,repeated
R17625 T22497 T22497 ROOT repeated,repeated
R17626 T22498 T22497 prep on,repeated
R17627 T22499 T22501 nummod three,WT
R17628 T22500 T22501 amod other,WT
R17629 T22501 T22498 pobj WT,on
R17630 T22502 T22501 cc and,WT
R17631 T22503 T22507 nummod two,mice
R17632 T22504 T22507 amod other,mice
R17633 T22505 T22507 compound LMP1,mice
R17634 T22506 T22507 compound transgenic,mice
R17635 T22507 T22501 conj mice,WT
R17636 T22508 T22507 prep with,mice
R17637 T22509 T22510 amod similar,results
R17638 T22510 T22508 pobj results,with
R17639 T22511 T22497 punct .,repeated
R17640 T22512 T22516 punct (,analysis
R17641 T22513 T22516 nmod C,analysis
R17642 T22514 T22513 punct ),C
R17643 T22515 T22516 compound Immunoblot,analysis
R17644 T22516 T22516 ROOT analysis,analysis
R17645 T22517 T22516 prep for,analysis
R17646 T22518 T22522 nmod κ,chains
R17647 T22519 T22518 cc and,κ
R17648 T22520 T22522 compound λ,chains
R17649 T22521 T22522 compound light,chains
R17650 T22522 T22517 pobj chains,for
R17651 T22523 T22522 prep of,chains
R17652 T22524 T22525 compound B,cells
R17653 T22525 T22523 pobj cells,of
R17654 T22526 T22516 punct (,analysis
R17655 T22527 T22528 nummod CD19,+
R17656 T22528 T22516 appos +,analysis
R17657 T22529 T22516 punct ),analysis
R17658 T22530 T22530 ROOT purified,purified
R17659 T22531 T22530 prep from,purified
R17660 T22532 T22536 nmod WT,mice
R17661 T22533 T22532 cc and,WT
R17662 T22534 T22532 conj LMP1,WT
R17663 T22535 T22536 amod transgenic,mice
R17664 T22536 T22531 pobj mice,from
R17665 T22537 T22530 punct .,purified
R17666 T22538 T22540 nsubjpass Actin,used
R17667 T22539 T22540 auxpass was,used
R17668 T22540 T22540 ROOT used,used
R17669 T22541 T22540 prep as,used
R17670 T22542 T22544 det a,control
R17671 T22543 T22544 compound loading,control
R17672 T22544 T22541 pobj control,as
R17673 T22545 T22540 punct .,used
R17852 T22851 T22851 ROOT LMP1,LMP1
R17853 T22852 T22852 ROOT Promotes,Promotes
R17854 T22853 T22855 compound B,Survival
R17855 T22854 T22855 compound Cell,Survival
R17856 T22855 T22852 dobj Survival,Promotes
R17857 T22856 T22855 cc and,Survival
R17858 T22857 T22855 conj Proliferation,Survival
R17859 T22858 T22858 ROOT In,In
R17860 T22859 T22861 nmod Vitro,A
R17861 T22860 T22861 punct (,A
R17862 T22861 T22858 pobj A,In
R17863 T22862 T22861 punct ),A
R17864 T22863 T22864 compound MTS,assay
R17865 T22864 T22858 pobj assay,In
R17866 T22865 T22864 prep of,assay
R17867 T22866 T22865 pobj splenocytes,of
R17868 T22867 T22866 prep from,splenocytes
R17869 T22868 T22872 nmod WT,mice
R17870 T22869 T22868 cc and,WT
R17871 T22870 T22868 conj LMP1,WT
R17886 T22885 T22882 conj absence,bars
R17887 T22886 T22888 punct (,bars
R17888 T22887 T22888 amod black,bars
R17889 T22888 T22885 appos bars,absence
R17890 T22889 T22882 punct ),bars
R17891 T22890 T22882 prep of,bars
R17892 T22891 T22890 pobj IL4,of
R17893 T22892 T22875 prep for,were
R17894 T22893 T22894 nummod 3,d
R17895 T22894 T22892 pobj d,for
R17896 T22895 T22875 punct .,were
R17897 T22896 T22897 det The,results
R17898 T22897 T22898 nsubj results,are
R17899 T22898 T22898 ROOT are,are
R17900 T22899 T22902 det the,SEM
R17901 T22900 T22902 amod mean,SEM
R17902 T22901 T22902 compound ±,SEM
R17903 T22902 T22898 attr SEM,are
R17904 T22903 T22902 prep of,SEM
R17905 T22904 T22905 compound triplicate,samples
R17906 T22905 T22903 pobj samples,of
R17907 T22906 T22902 acl averaged,SEM
R17908 T22907 T22906 prep from,averaged
R17909 T22908 T22909 amod multiple,mice
R17910 T22909 T22907 pobj mice,from
R17911 T22910 T22917 advmod where,is
R17912 T22911 T22911 ROOT n,n
R17913 T22912 T22913 det the,number
R17914 T22913 T22917 nsubj number,is
R17915 T22914 T22913 prep of,number
R17916 T22915 T22914 pobj mice,of
R17917 T22916 T22915 acl analyzed,mice
R17918 T22917 T22909 relcl is,mice
R17919 T22918 T22919 mark as,follows
R17920 T22919 T22917 advcl follows,is
R17921 T22920 T22909 punct :,mice
R17922 T22921 T22906 dobj n,averaged
R17923 T22922 T22923 punct =,2
R17924 T22923 T22921 nummod 2,n
R17925 T22924 T22921 prep for,n
R17926 T22925 T22926 compound WT,lymphocytes
R17927 T22926 T22924 pobj lymphocytes,for
R17928 T22927 T22926 cc and,lymphocytes
R17929 T22928 T22929 compound WT,lymphomas
R17930 T22929 T22926 conj lymphomas,lymphocytes
R17931 T22930 T22921 punct ",",n
R17932 T22931 T22933 dep n,11
R17933 T22932 T22933 punct =,11
R17934 T22933 T22921 dep 11,n
R17935 T22934 T22933 prep for,11
R17936 T22935 T22937 nummod LMP1,lymphocytes
R17937 T22936 T22937 amod transgenic,lymphocytes
R17938 T22937 T22934 pobj lymphocytes,for
R17939 T22938 T22933 punct ",",11
R17940 T22939 T22933 cc and,11
R17941 T22940 T22942 amod n,13
R17942 T22941 T22942 punct =,13
R17943 T22942 T22933 conj 13,11
R17944 T22943 T22942 prep for,13
R17945 T22944 T22946 nummod LMP1,lymphomas
R17946 T22945 T22946 amod transgenic,lymphomas
R17947 T22946 T22943 pobj lymphomas,for
R17948 T22947 T22898 punct .,are
R17949 T22948 T22949 punct (,B
R17950 T22949 T22949 ROOT B,B
R17951 T22950 T22949 punct ),B
R17952 T22951 T22952 compound EMA,exclusion
R17953 T22952 T22956 nsubj exclusion,gated
R17954 T22953 T22952 prep of,exclusion
R17955 T22954 T22955 compound CD19,+
R17956 T22955 T22953 pobj +,of
R17957 T22956 T22956 ROOT gated,gated
R17958 T22957 T22956 dobj splenocytes,gated
R17959 T22958 T22957 prep from,splenocytes
R17960 T22959 T22963 nmod WT,mice
R17961 T22960 T22959 cc and,WT
R17962 T22961 T22959 conj LMP1,WT
R17963 T22962 T22963 amod transgenic,mice
R17964 T22963 T22958 pobj mice,from
R17965 T22964 T22956 advcl showing,gated
R17966 T22965 T22964 dobj percentage,showing
R17967 T22966 T22965 prep of,percentage
R17968 T22967 T22969 amod viable,cells
R17969 T22968 T22969 compound B,cells
R17970 T22969 T22966 pobj cells,of
R17971 T22970 T22956 conj cultured,gated
R17972 T22971 T22970 prep with,cultured
R17973 T22972 T22974 punct (,bars
R17974 T22973 T22974 amod white,bars
R17975 T22974 T22971 pobj bars,with
R17976 T22975 T22970 punct ),cultured
R17977 T22976 T22956 cc or,gated
R17978 T22977 T22956 conj without,gated
R17979 T22978 T22980 punct (,bars
R17980 T22979 T22980 amod black,bars
R17981 T22980 T22977 pobj bars,without
R17982 T22981 T22956 punct ),gated
R17983 T22982 T22982 ROOT IL4,IL4
R17984 T22983 T22982 prep for,IL4
R17985 T22984 T22985 nummod 2,d.
R17986 T22985 T22983 pobj d.,for
R17987 T22986 T22987 punct (,C
R17988 T22987 T22982 appos C,IL4
R17989 T22988 T22987 punct ),C
R17990 T22989 T22991 compound Flow,analysis
R17991 T22990 T22991 compound cytometry,analysis
R17992 T22991 T23002 nsubj analysis,cultured
R17993 T22992 T22991 prep for,analysis
R17994 T22993 T22994 amod incorporated,BrdU
R17995 T22994 T22992 pobj BrdU,for
R17996 T22995 T22994 prep in,BrdU
R17997 T22996 T22995 pobj WT,in
R17998 T22997 T22996 cc and,WT
R17999 T22998 T22996 conj LMP1,WT
R18000 T22999 T23001 amod transgenic,cells
R18001 T23000 T23001 compound lymphoma,cells
R18002 T23001 T22992 pobj cells,for
R18003 T23002 T23011 acomp cultured,are
R18004 T23003 T23002 prep with,cultured
R18005 T23004 T23003 cc or,with
R18006 T23005 T23003 conj without,with
R18007 T23006 T23005 pobj IL4,without
R18008 T23007 T23002 prep for,cultured
R18009 T23008 T23009 nummod 2,d.
R18010 T23009 T23010 compound d.,Shown
R18011 T23010 T23007 pobj Shown,for
R18012 T23011 T23011 ROOT are,are
R18013 T23012 T23013 det the,results
R18014 T23013 T23011 nsubj results,are
R18015 T23014 T23013 prep from,results
R18016 T23015 T23016 compound WT,lymphoma
R18017 T23016 T23014 pobj lymphoma,from
R18018 T23017 T23016 nummod 1,lymphoma
R18019 T23018 T23016 cc and,lymphoma
R18020 T23019 T23021 nummod LMP1,lymphoma
R18021 T23020 T23021 amod transgenic,lymphoma
R18022 T23021 T23016 conj lymphoma,lymphoma
R18023 T23022 T23021 nummod 2,lymphoma
R18024 T23023 T23011 punct .,are
R18025 T23024 T23031 nsubjpass Percentages,shown
R18026 T23025 T23024 prep of,Percentages
R18027 T23026 T23025 pobj cells,of
R18028 T23027 T23024 prep in,Percentages
R18029 T23028 T23029 det each,quadrant
R18030 T23029 T23027 pobj quadrant,in
R18031 T23030 T23031 auxpass are,shown
R18032 T23031 T23031 ROOT shown,shown
R18033 T23032 T23031 punct .,shown
R18233 T23362 T23368 nsubj Wild-Type,Survive
R18234 T23363 T23362 cc and,Wild-Type
R18235 T23364 T23367 compound LMP1,Cells
R18236 T23365 T23367 compound Transgenic,Cells
R18237 T23366 T23367 compound Lymphoma,Cells
R18238 T23367 T23362 conj Cells,Wild-Type
R18239 T23368 T23368 ROOT Survive,Survive
R18240 T23369 T23368 dobj Independently,Survive
R18241 T23370 T23369 prep of,Independently
R18242 T23371 T23372 compound IL4/Stat6,Signaling
R18243 T23372 T23370 pobj Signaling,of
R18244 T23373 T23372 prep in,Signaling
R18245 T23374 T23373 pobj Culture,in
R18246 T23375 T23372 punct (,Signaling
R18247 T23376 T23372 npadvmod A,Signaling
R18248 T23377 T23376 punct ),A
R18249 T23378 T23378 ROOT Rnase,Rnase
R18250 T23379 T23380 compound protection,assay
R18251 T23380 T23378 dobj assay,Rnase
R18252 T23381 T23380 prep for,assay
R18253 T23382 T23383 compound IL4,mRNA
R18254 T23383 T23381 pobj mRNA,for
R18255 T23384 T23383 prep from,mRNA
R18256 T23385 T23387 amod purified,cells
R18257 T23386 T23387 compound B,cells
R18258 T23387 T23384 pobj cells,from
R18259 T23388 T23387 punct (,cells
R18260 T23389 T23390 nummod CD19,+
R18261 T23390 T23387 appos +,cells
R18262 T23391 T23387 punct ),cells
R18263 T23392 T23384 prep from,from
R18264 T23393 T23397 nmod WT,splenocytes
R18265 T23394 T23393 cc and,WT
R18266 T23395 T23393 conj LMP1,WT
R18267 T23396 T23397 amod transgenic,splenocytes
R18268 T23397 T23392 pobj splenocytes,from
R18269 T23398 T23378 punct .,Rnase
R18270 T23399 T23400 det The,L32
R18271 T23400 T23404 nmod L32,genes
R18272 T23401 T23400 cc and,L32
R18273 T23402 T23400 conj GAPDH,L32
R18274 T23403 T23404 compound housekeeping,genes
R18275 T23404 T23406 nsubjpass genes,used
R18276 T23405 T23406 auxpass were,used
R18277 T23406 T23406 ROOT used,used
R18278 T23407 T23406 prep as,used
R18279 T23408 T23410 det a,control
R18280 T23409 T23410 compound loading,control
R18281 T23410 T23407 pobj control,as
R18282 T23411 T23406 punct .,used
R18283 T23412 T23413 nsubj Arrow,indicates
R18284 T23413 T23413 ROOT indicates,indicates
R18285 T23414 T23415 det the,position
R18286 T23415 T23413 dobj position,indicates
R18287 T23416 T23415 prep of,position
R18288 T23417 T23419 det the,probe
R18289 T23418 T23419 amod protected,probe
R18290 T23419 T23416 pobj probe,of
R18291 T23420 T23413 punct .,indicates
R18292 T23421 T23427 punct (,analysis
R18293 T23422 T23427 nmod B,analysis
R18294 T23423 T23422 cc and,B
R18295 T23424 T23422 conj C,B
R18296 T23425 T23422 punct ),B
R18297 T23426 T23427 compound Immunoblot,analysis
R18298 T23427 T23460 dep analysis,cultured
R18299 T23428 T23427 prep of,analysis
R18300 T23429 T23428 pobj WT,of
R18301 T23430 T23429 cc and,WT
R18302 T23431 T23429 conj LMP1,WT
R18303 T23432 T23433 amod transgenic,mice
R18304 T23433 T23427 conj mice,analysis
R18305 T23434 T23433 prep for,mice
R18306 T23435 T23436 amod activated,pStat6
R18308 T23437 T23436 prep in,pStat6
R18309 T23438 T23439 punct (,B
R18310 T23439 T23437 pobj B,in
R18311 T23440 T23433 punct ),mice
R18312 T23441 T23443 amod purified,cells
R18313 T23442 T23443 compound B,cells
R18314 T23443 T23427 appos cells,analysis
R18315 T23444 T23443 punct (,cells
R18316 T23445 T23446 nummod CD19,+
R18317 T23446 T23443 appos +,cells
R18318 T23447 T23443 punct ),cells
R18319 T23448 T23427 prep at,analysis
R18320 T23449 T23450 det the,time
R18321 T23450 T23448 pobj time,at
R18322 T23451 T23450 prep of,time
R18323 T23452 T23451 pobj harvest,of
R18324 T23453 T23448 cc or,at
R18325 T23454 T23448 conj in,at
R18326 T23455 T23454 punct (,in
R18327 T23456 T23454 pobj C,in
R18328 T23457 T23456 punct ),C
R18329 T23458 T23459 amod whole,splenocytes
R18330 T23459 T23460 nsubj splenocytes,cultured
R18331 T23460 T23460 ROOT cultured,cultured
R18332 T23461 T23460 prep with,cultured
R18333 T23462 T23461 cc or,with
R18334 T23463 T23461 conj without,with
R18335 T23464 T23463 pobj IL4,without
R18336 T23465 T23460 punct .,cultured
R18337 T23466 T23467 punct (,B
R18338 T23467 T23467 ROOT B,B
R18339 T23468 T23467 punct ),B
R18340 T23469 T23471 nsubjpass Actin,used
R18341 T23470 T23471 auxpass was,used
R18342 T23471 T23471 ROOT used,used
R18343 T23472 T23471 prep as,used
R18344 T23473 T23475 det a,control
R18345 T23474 T23475 compound loading,control
R18346 T23475 T23472 pobj control,as
R18347 T23476 T23471 punct ",",used
R18348 T23477 T23471 cc and,used
R18349 T23478 T23480 det the,line
R18350 T23479 T23480 amod white,line
R18351 T23480 T23481 nsubj line,indicates
R18352 T23481 T23471 conj indicates,used
R18353 T23482 T23487 mark that,spliced
R18354 T23483 T23484 amod intervening,lanes
R18355 T23484 T23487 nsubjpass lanes,spliced
R18356 T23485 T23487 aux have,spliced
R18357 T23486 T23487 auxpass been,spliced
R18358 T23487 T23481 ccomp spliced,indicates
R18359 T23488 T23487 prt out,spliced
R18378 T23507 T23510 nummod LMP1,cells
R18379 T23508 T23510 amod transgenic,cells
R18380 T23509 T23510 compound lymphoma,cells
R18381 T23510 T23502 conj cells,lymphocytes
R18382 T23511 T23502 acl cultured,lymphocytes
R18383 T23512 T23511 prep with,cultured
R18384 T23513 T23512 pobj IL4,with
R18385 T23514 T23513 punct ",",IL4
R18386 T23515 T23517 det a,antibody
R18387 T23516 T23517 amod neutralizing,antibody
R18388 T23517 T23513 appos antibody,IL4
R18389 T23518 T23517 prep to,antibody
R18390 T23519 T23518 pobj IL4,to
R18391 T23520 T23519 punct ",",IL4
R18392 T23521 T23519 cc or,IL4
R18393 T23522 T23523 det a,rat
R18394 T23523 T23526 compound rat,control
R18395 T23524 T23526 compound IgG,control
R18396 T23525 T23526 compound isotype,control
R18397 T23526 T23517 conj control,antibody
R18398 T23527 T23526 prep at,control
R18399 T23528 T23530 det the,concentrations
R18400 T23529 T23530 amod indicated,concentrations
R18401 T23530 T23527 pobj concentrations,at
R18402 T23531 T23496 punct .,assay
R18403 T23532 T23532 ROOT Shown,Shown
R18404 T23533 T23532 auxpass are,Shown
R18405 T23534 T23535 det the,results
R18406 T23535 T23532 nsubjpass results,Shown
R18407 T23536 T23535 prep from,results
R18408 T23537 T23539 nummod LMP1,lymphoma
R18409 T23538 T23539 amod transgenic,lymphoma
R18410 T23539 T23536 pobj lymphoma,from
R18411 T23540 T23539 nummod 3,lymphoma
R18412 T23541 T23532 punct .,Shown
R18413 T23542 T23543 det The,results
R18414 T23543 T23544 nsubj results,are
R18415 T23544 T23544 ROOT are,are
R18416 T23545 T23548 det the,SEM
R18417 T23546 T23548 amod mean,SEM
R18418 T23547 T23548 compound ±,SEM
R18419 T23548 T23544 attr SEM,are
R18420 T23549 T23548 prep of,SEM
R18421 T23550 T23551 compound triplicate,samples
R18422 T23551 T23549 pobj samples,of
R18423 T23552 T23548 prep from,SEM
R18424 T23553 T23556 det a,experiment
R18425 T23554 T23556 amod single,experiment
R18676 T23965 T23964 cc and,Expression
R18677 T23966 T23964 conj Constitutively,Expression
R18678 T23967 T23967 ROOT Activates,Activates
R18679 T23968 T23967 dobj Stat3,Activates
R18747 T24036 T24038 nsubjpass ratio,set
R18748 T24037 T24038 auxpass was,set
R18749 T24038 T24038 ROOT set,set
R18789 T24078 T24079 det the,time
R18790 T24079 T24077 pobj time,at
R18792 T24081 T24080 pobj harvest,of
R18793 T24082 T24056 punct ",",analysis
R18794 T24083 T24056 cc and,analysis
R18795 T24084 T24085 punct (,C
R18796 T24085 T24056 conj C,analysis
R18797 T24086 T24085 punct ),C
R18798 T24087 T24088 nummod 4,h
R18799 T24088 T24056 appos h,analysis
R18800 T24089 T24088 prep after,h
R18801 T24090 T24089 pobj culture,after
R18802 T24091 T24088 prep with,h
R18803 T24092 T24091 cc or,with
R18804 T24093 T24091 conj without,with
R18805 T24094 T24093 pobj IL10,without
R18806 T24095 T24094 punct ",",IL10
R18807 T24096 T24098 det a,antibody
R18808 T24097 T24098 amod neutralizing,antibody
R18809 T24098 T24094 appos antibody,IL10
R18810 T24099 T24098 prep to,antibody
R18811 T24100 T24099 pobj IL10,to
R18812 T24101 T24100 punct ",",IL10
R18813 T24102 T24100 cc or,IL10
R18814 T24103 T24107 det a,control
R18815 T24104 T24107 nmod rat,control
R18816 T24105 T24107 amod IgG1,control
R18817 T24106 T24107 compound isotype,control
R18818 T24107 T24100 conj control,IL10
R18819 T24108 T24056 punct .,analysis
R18820 T24109 T24110 punct (,C
R18821 T24110 T24110 ROOT C,C
R18822 T24111 T24110 punct ),C
R18823 T24112 T24112 ROOT Shown,Shown
R18824 T24113 T24112 auxpass are,Shown
R18825 T24114 T24115 det the,results
R18826 T24115 T24112 nsubjpass results,Shown
R18827 T24116 T24115 prep for,results
R18828 T24117 T24118 compound WT,lymphoma
R18829 T24118 T24116 pobj lymphoma,for
R18830 T24119 T24118 nummod 1,lymphoma
R18831 T24120 T24118 cc and,lymphoma
R18832 T24121 T24123 nummod LMP1,lymphoma
R18833 T24122 T24123 amod transgenic,lymphoma
R18834 T24123 T24118 conj lymphoma,lymphoma
R18835 T24124 T24123 nummod 1,lymphoma
R18836 T24125 T24112 punct .,Shown
R18837 T24126 T24127 nsubj Arrows,indicate
R18838 T24127 T24127 ROOT indicate,indicate
R18839 T24128 T24129 det the,positions
R18840 T24129 T24127 dobj positions,indicate
R18841 T24130 T24129 prep of,positions
R18842 T24131 T24132 det the,α
R18843 T24132 T24130 pobj α,of
R18844 T24133 T24132 cc and,α
R18845 T24134 T24135 compound β,isoforms
R18846 T24135 T24132 conj isoforms,α
R18847 T24136 T24132 prep of,α
R18848 T24137 T24136 pobj Stat3,of
R18849 T24138 T24127 punct .,indicate
R18850 T24139 T24141 nsubjpass Actin,used
R18851 T24140 T24141 auxpass was,used
R18852 T24141 T24141 ROOT used,used
R18853 T24142 T24141 prep as,used
R18854 T24143 T24145 det a,control
R18855 T24144 T24145 compound loading,control
R18856 T24145 T24142 pobj control,as
R18857 T24146 T24141 punct .,used
R18858 T24147 T24151 punct (,detection
R18859 T24148 T24151 compound D,detection
R18860 T24149 T24150 punct ),Immunohistochemistry
R18861 T24150 T24151 compound Immunohistochemistry,detection
R18862 T24151 T24151 ROOT detection,detection
R18863 T24152 T24151 prep of,detection
R18864 T24153 T24155 amod activated,pStat3
R18865 T24154 T24155 amod nuclear,pStat3
R18866 T24155 T24152 pobj pStat3,of
R18867 T24156 T24151 prep in,detection
R18868 T24157 T24158 det the,spleens
R18869 T24158 T24156 pobj spleens,in
R18870 T24159 T24158 prep of,spleens
R18871 T24160 T24164 nmod WT,mice
R18872 T24161 T24160 cc and,WT
R18873 T24162 T24160 conj LMP1,WT
R18874 T24163 T24164 amod transgenic,mice
R19079 T24535 T24534 punct ),B
R19080 T24536 T24537 compound Immunoblot,analysis
R19081 T24537 T24564 nsubj analysis,activated
R19082 T24538 T24537 prep of,analysis
R19083 T24539 T24541 amod purified,cells
R19084 T24540 T24541 compound B,cells
R19085 T24541 T24538 pobj cells,of
R19086 T24542 T24541 punct (,cells
R19087 T24543 T24544 nummod CD19,+
R19088 T24544 T24541 appos +,cells
R19089 T24545 T24541 punct ),cells
R19090 T24546 T24537 prep from,analysis
R19091 T24547 T24548 det the,spleens
R19092 T24548 T24546 pobj spleens,from
R19093 T24549 T24548 prep of,spleens
R19094 T24550 T24549 pobj WT,of
R19095 T24551 T24550 cc and,WT
R19096 T24552 T24550 conj LMP1,WT
R19097 T24553 T24554 amod transgenic,mice
R19098 T24554 T24548 conj mice,spleens
R19099 T24555 T24537 prep for,analysis
R19100 T24556 T24557 compound Akt,signaling
R19101 T24557 T24555 pcomp signaling,for
R19102 T24558 T24557 punct ",",signaling
R19103 T24559 T24557 conj probing,signaling
R19104 T24560 T24559 prep for,probing
R19105 T24561 T24562 punct (,A
R19106 T24562 T24560 pobj A,for
R19107 T24563 T24562 punct ),A
R19108 T24564 T24564 ROOT activated,activated
R19109 T24565 T24564 dobj pAkt,activated
R19110 T24566 T24565 cc and,pAkt
R19111 T24567 T24568 amod downstream,targets
R19112 T24568 T24565 conj targets,pAkt
R19113 T24569 T24568 punct ",",targets
R19114 T24570 T24568 prep including,targets
R19115 T24571 T24574 amod inactivated,β
R19116 T24572 T24574 amod pGSK3α,β
R19117 T24573 T24574 compound /,β
R19118 T24574 T24570 pobj β,including
R19119 T24575 T24568 punct ",",targets
R19120 T24576 T24568 cc and,targets
R19121 T24577 T24578 punct (,B
R19122 T24578 T24568 conj B,targets
R19123 T24579 T24564 punct ),activated
R19124 T24580 T24580 ROOT activated,activated
R19125 T24581 T24580 dobj p-mTOR,activated
R19126 T24582 T24581 punct ",",p-mTOR
R19127 T24583 T24581 cc and,p-mTOR
R19128 T24584 T24585 amod total,levels
R19129 T24585 T24581 conj levels,p-mTOR
R19130 T24586 T24585 prep of,levels
R19131 T24587 T24586 pobj FoxO1,of
R19132 T24588 T24580 punct .,activated
R19133 T24589 T24590 nsubj Arrows,indicate
R19134 T24590 T24590 ROOT indicate,indicate
R19135 T24591 T24592 det the,positions
R19136 T24592 T24590 dobj positions,indicate
R19137 T24593 T24592 prep of,positions
R19138 T24594 T24593 pobj α,of
R19139 T24595 T24594 cc and,α
R19140 T24596 T24594 conj β,α
R19141 T24597 T24592 conj isoforms,positions
R19142 T24598 T24592 prep of,positions
R19143 T24599 T24598 pobj GSK3,of
R19144 T24600 T24590 punct .,indicate
R19145 T24601 T24603 det The,line
R19146 T24602 T24603 amod white,line
R19147 T24603 T24604 nsubj line,indicates
R19148 T24604 T24604 ROOT indicates,indicates
R19149 T24605 T24610 mark that,spliced
R19150 T24606 T24607 amod intervening,lanes
R19151 T24607 T24610 nsubjpass lanes,spliced
R19152 T24608 T24610 aux have,spliced
R19153 T24609 T24610 auxpass been,spliced
R19154 T24610 T24604 ccomp spliced,indicates
R19155 T24611 T24610 prt out,spliced
R19156 T24612 T24604 punct .,indicates
R19157 T24613 T24617 punct (,analysis
R19158 T24614 T24617 nmod C,analysis
R19159 T24615 T24614 punct ),C
R19160 T24616 T24617 compound Immunoblot,analysis
R19161 T24617 T24617 ROOT analysis,analysis
R19162 T24618 T24617 prep for,analysis
R19163 T24619 T24620 compound cell,cycle
R19164 T24620 T24621 compound cycle,proteins
R19165 T24621 T24618 pobj proteins,for
R19166 T24622 T24621 acl regulating,proteins
R19167 T24623 T24625 det the,pathway
R19168 T24624 T24625 compound Rb,pathway
R19169 T24625 T24622 dobj pathway,regulating
R19170 T24626 T24617 punct ",",analysis
R19171 T24627 T24617 acl probing,analysis
R19172 T24628 T24627 prep for,probing
R19173 T24629 T24630 amod activated,pRb
R19174 T24630 T24628 pobj pRb,for
R19175 T24631 T24630 punct ",",pRb
R19176 T24632 T24627 cc and,probing
R19177 T24633 T24634 amod total,levels
R19178 T24634 T24627 conj levels,probing
R19179 T24635 T24634 prep of,levels
R19180 T24636 T24635 pobj Cdk2,of
R19181 T24637 T24636 cc and,Cdk2
R19182 T24638 T24640 det the,inhibitor
R19183 T24639 T24640 compound Cdk,inhibitor
R19184 T24640 T24641 compound inhibitor,p27
R19185 T24641 T24636 conj p27,Cdk2
R19186 T24642 T24617 punct .,analysis
R19187 T24643 T24645 nsubjpass Actin,used
R19188 T24644 T24645 auxpass was,used
R19189 T24645 T24645 ROOT used,used
R19190 T24646 T24645 prep as,used
R19191 T24647 T24649 det a,control
R19192 T24648 T24649 compound loading,control
R19193 T24649 T24646 pobj control,as
R19194 T24650 T24645 punct .,used
R19380 T24974 T24982 nsubjpass Akt,Required
R19381 T24975 T24974 punct ",",Akt
R19382 T24976 T24974 conj NFκB,Akt
R19383 T24977 T24976 punct ",",NFκB
R19384 T24978 T24976 cc and,NFκB
R19385 T24979 T24976 conj Stat3,NFκB
R19386 T24980 T24976 conj Signaling,NFκB
R19387 T24981 T24982 auxpass Are,Required
R19388 T24982 T24982 ROOT Required,Required
R19389 T24983 T24982 prep for,Required
R19390 T24984 T24992 det the,assay
R19391 T24985 T24992 nmod Growth,assay
R19392 T24986 T24985 cc and,Growth
R19393 T24987 T24985 conj Survival,Growth
R19394 T24988 T24985 prep of,Growth
R19395 T24989 T24991 compound Lymphoma,MTS
R19396 T24990 T24991 compound Cells,MTS
R19397 T24991 T24992 compound MTS,assay
R19398 T24992 T24983 pobj assay,for
R19399 T24993 T24992 prep of,assay
R19400 T24994 T24993 pobj splenocytes,of
R19401 T24995 T24992 prep from,assay
R19402 T24996 T24997 punct (,A
R19403 T24997 T24995 pobj A,from
R19404 T24998 T24997 cc and,A
R19405 T24999 T25001 nmod B,WT
R19406 T25000 T25001 punct ),WT
R19407 T25001 T25010 nmod WT,lymphomas
R19408 T25002 T25001 cc or,WT
R19409 T25003 T25001 punct (,WT
R19410 T25004 T25001 conj C,WT
R19411 T25005 T25004 cc and,C
R19412 T25006 T25004 conj D,C
R19413 T25007 T25004 punct ),C
R19414 T25008 T25010 nummod LMP1,lymphomas
R19415 T25009 T25010 amod transgenic,lymphomas
R19416 T25010 T24997 conj lymphomas,A
R19417 T25011 T25010 cc and,lymphomas
R19418 T25012 T25010 punct (,lymphomas
R19419 T25013 T25019 nmod E,lymphoctyes
R19420 T25014 T25013 cc and,E
R19421 T25015 T25013 conj F,E
R19422 T25016 T25013 punct ),E
R19423 T25017 T25019 nummod LMP1,lymphoctyes
R19424 T25018 T25019 amod transgenic,lymphoctyes
R19425 T25019 T25010 appos lymphoctyes,lymphomas
R19426 T25020 T25010 punct .,lymphomas
R19427 T25021 T25023 nsubjpass Splenocytes,cultured
R19428 T25022 T25023 auxpass were,cultured
R19429 T25023 T25023 ROOT cultured,cultured
R19430 T25024 T25023 prep with,cultured
R19431 T25025 T25024 cc or,with
R19432 T25026 T25024 conj without,with
R19433 T25027 T25026 pobj inhibitors,without
R19434 T25028 T25027 prep of,inhibitors
R19435 T25029 T25028 pobj NFκB,of
R19436 T25030 T25029 punct (,NFκB
R19437 T25031 T25029 appos BAY11,NFκB
R19438 T25032 T25029 punct ),NFκB
R19439 T25033 T25029 punct ",",NFκB
R19440 T25034 T25057 nmod mTOR,cucurbitacin
R19441 T25035 T25036 punct (,rapamycin
R19442 T25036 T25034 appos rapamycin,mTOR
R19443 T25037 T25036 punct ),rapamycin
R19444 T25038 T25034 punct ",",mTOR
R19445 T25039 T25034 conj Akt,mTOR
R19446 T25040 T25041 punct (,triciribine
R19447 T25041 T25039 appos triciribine,Akt
R19448 T25042 T25041 punct ),triciribine
R19449 T25043 T25039 punct ",",Akt
R19450 T25044 T25039 conj MEK1/2,Akt
R19451 T25045 T25046 punct (,U0126
R19452 T25046 T25044 appos U0126,MEK1/2
R19453 T25047 T25044 punct ),MEK1/2
R19454 T25048 T25044 punct ",",MEK1/2
R19455 T25049 T25057 nmod p38,cucurbitacin
R19456 T25050 T25049 punct (,p38
R19457 T25051 T25049 appos SB202190,p38
R19458 T25052 T25049 punct ),p38
R19459 T25053 T25049 punct ",",p38
R19460 T25054 T25049 cc or,p38
R19461 T25055 T25049 conj Stat3,p38
R19462 T25056 T25057 punct (,cucurbitacin
R19463 T25057 T25023 npadvmod cucurbitacin,cultured
R19464 T25058 T25060 nsubj I,AG490
R19465 T25059 T25058 cc and,I
R19466 T25060 T25057 appos AG490,cucurbitacin
R19467 T25061 T25060 punct ),AG490
R19468 T25062 T25057 prep at,cucurbitacin
R19469 T25063 T25065 det the,concentrations
R19470 T25064 T25065 amod indicated,concentrations
R19471 T25065 T25062 pobj concentrations,at
R19472 T25066 T25023 punct .,cultured
R19473 T25067 T25068 det The,results
R19474 T25068 T25069 nsubj results,are
R19475 T25069 T25069 ROOT are,are
R19476 T25070 T25073 det the,SEM
R19477 T25071 T25073 amod mean,SEM
R19478 T25072 T25073 compound ±,SEM
R19479 T25073 T25069 attr SEM,are
R19480 T25074 T25073 prep of,SEM
R19481 T25075 T25076 compound triplicate,samples
R19482 T25076 T25074 pobj samples,of
R19483 T25077 T25069 punct .,are
R19484 T25078 T25078 ROOT Shown,Shown
R19485 T25079 T25078 auxpass are,Shown
R19486 T25080 T25081 det the,results
R19487 T25081 T25078 nsubjpass results,Shown
R19488 T25082 T25081 prep for,results
R19489 T25083 T25084 punct (,A
R19490 T25084 T25082 pobj A,for
R19491 T25085 T25084 cc and,A
R19492 T25086 T25084 conj B,A
R19493 T25087 T25086 punct ),B
R19494 T25088 T25089 compound WT,lymphoma
R19495 T25089 T25115 nsubj lymphoma,analyzed
R19496 T25090 T25089 nummod 1,lymphoma
R19497 T25091 T25089 punct ",",lymphoma
R19498 T25092 T25093 punct (,C
R19499 T25093 T25089 appos C,lymphoma
R19500 T25094 T25093 cc and,C
R19501 T25095 T25093 conj D,C
R19502 T25096 T25093 punct ),C
R19503 T25097 T25093 appos LMP1,C
R19504 T25098 T25099 amod transgenic,lymphoma
R19505 T25099 T25097 pobj lymphoma,LMP1
R19506 T25100 T25099 nummod 2,lymphoma
R19507 T25101 T25093 punct ",",C
R19508 T25102 T25089 cc and,lymphoma
R19509 T25103 T25104 punct (,E
R19510 T25104 T25104 ROOT E,E
R19511 T25105 T25104 cc and,E
R19512 T25106 T25104 conj F,E
R19513 T25107 T25106 punct ),F
R19514 T25108 T25115 nsubj one,analyzed
R19515 T25109 T25108 prep out,one
R19516 T25110 T25109 prep of,out
R19517 T25111 T25114 nummod two,mice
R19518 T25112 T25114 nummod LMP1,mice
R19519 T25113 T25114 amod transgenic,mice
R19520 T25114 T25110 pobj mice,of
R19521 T25115 T25115 ROOT analyzed,analyzed
R19522 T25116 T25115 punct .,analyzed
R19523 T25117 T25118 det This,analysis
R19524 T25118 T25120 nsubjpass analysis,repeated
R19525 T25119 T25120 auxpass was,repeated
R19526 T25120 T25120 ROOT repeated,repeated
R19527 T25121 T25120 prep with,repeated
R19528 T25122 T25126 nsubj LMP1,yielding
R19529 T25123 T25124 amod transgenic,lymphoma
R19530 T25124 T25126 dep lymphoma,yielding
R19531 T25125 T25124 nummod 4,lymphoma
R19532 T25126 T25121 pcomp yielding,with
R19533 T25127 T25128 amod similar,results
R19534 T25128 T25126 dobj results,yielding
R19535 T25129 T25120 punct .,repeated
R19657 T25354 T25354 ROOT Analysis,Analysis
R19658 T25355 T25354 prep of,Analysis
R19659 T25356 T25355 pobj Akt,of
R19660 T25357 T25356 punct ",",Akt
R19661 T25358 T25356 conj NFκB,Akt
R19662 T25359 T25358 punct ",",NFκB
R19663 T25360 T25358 cc and,NFκB
R19664 T25361 T25362 compound Stat3,Pathways
R19665 T25362 T25358 conj Pathways,NFκB
R19666 T25363 T25354 prep in,Analysis
R19667 T25364 T25363 pobj Contribution,in
R19668 T25365 T25364 prep to,Contribution
R19669 T25366 T25367 det the,Growth
R19670 T25367 T25365 pobj Growth,to
R19671 T25368 T25367 cc and,Growth
R19672 T25369 T25367 conj Survival,Growth
R19673 T25370 T25367 prep of,Growth
R19674 T25371 T25372 compound Lymphoma,Cells
R19675 T25372 T25370 pobj Cells,of
R19676 T25373 T25374 punct (,A
R19677 T25374 T25367 appos A,Growth
R19678 T25375 T25378 poss D,analysis
R19679 T25376 T25375 punct ),D
R19680 T25377 T25378 compound Immunoblot,analysis
R19681 T25378 T25391 dative analysis,Stat3
R19682 T25379 T25378 prep of,analysis
R19683 T25380 T25384 nmod wild-type,lymphomas
R19684 T25381 T25380 cc and,wild-type
R19685 T25382 T25380 conj LMP1,wild-type
R19686 T25383 T25384 amod transgenic,lymphomas
R19687 T25384 T25379 pobj lymphomas,of
R19688 T25385 T25378 prep for,analysis
R19689 T25386 T25385 pobj Akt,for
R19690 T25387 T25386 punct ",",Akt
R19691 T25388 T25386 conj NFκB,Akt
R19692 T25389 T25388 punct ",",NFκB
R19693 T25390 T25388 cc and,NFκB
R19694 T25391 T25367 appos Stat3,Growth
R19695 T25392 T25391 acl signaling,Stat3
R19696 T25393 T25392 prep after,signaling
R19697 T25394 T25393 pobj treatment,after
R19698 T25395 T25394 prep with,treatment
R19699 T25396 T25397 punct (,A
R19700 T25397 T25395 pobj A,with
R19701 T25398 T25397 punct ),A
R19702 T25399 T25401 det an,inhibitor
R19703 T25400 T25401 compound Akt,inhibitor
R19704 T25401 T25394 conj inhibitor,treatment
R19705 T25402 T25401 punct ",",inhibitor
R19706 T25403 T25401 conj triciribine,inhibitor
R19707 T25404 T25392 punct ",",signaling
R19708 T25405 T25406 punct (,B
R19709 T25406 T25392 appos B,signaling
R19710 T25407 T25406 punct ),B
R19711 T25408 T25410 det an,inhibitor
R19712 T25409 T25410 compound NFκB,inhibitor
R19713 T25410 T25392 dobj inhibitor,signaling
R19714 T25411 T25410 punct ",",inhibitor
R19715 T25412 T25410 appos BAY11,inhibitor
R19716 T25413 T25410 appos 7085,inhibitor
R19717 T25414 T25410 punct ",",inhibitor
R19718 T25415 T25410 cc and,inhibitor
R19719 T25416 T25418 det the,inhibitors
R19720 T25417 T25418 amod Stat3,inhibitors
R19721 T25418 T25410 conj inhibitors,inhibitor
R19722 T25419 T25418 punct (,inhibitors
R19723 T25420 T25418 appos C,inhibitors
R19724 T25421 T25418 punct ),inhibitors
R19725 T25422 T25428 nmod cucurbitacin,AG490
R19726 T25423 T25428 nmod I,AG490
R19727 T25424 T25423 cc and,I
R19728 T25425 T25426 punct (,D
R19729 T25426 T25428 nmod D,AG490
R19730 T25427 T25428 punct ),AG490
R19731 T25428 T25410 appos AG490,inhibitor
R19732 T25429 T25410 punct ",",inhibitor
R19733 T25430 T25410 prep at,inhibitor
R19734 T25431 T25433 det the,concentrations
R19735 T25432 T25433 amod indicated,concentrations
R19736 T25433 T25430 pobj concentrations,at
R19737 T25434 T25354 punct .,Analysis
R19738 T25435 T25436 nsubj Arrows,indicate
R19739 T25436 T25436 ROOT indicate,indicate
R19740 T25437 T25438 det the,positions
R19741 T25438 T25436 dobj positions,indicate
R19742 T25439 T25438 prep of,positions
R19743 T25440 T25439 pobj α,of
R19744 T25441 T25440 cc and,α
R19745 T25442 T25440 conj β,α
R19746 T25443 T25438 conj isoforms,positions
R19747 T25444 T25438 prep of,positions
R19748 T25445 T25444 pobj Stat3,of
R19749 T25446 T25436 punct .,indicate
R19750 T25447 T25449 nsubjpass Actin,used
R19751 T25448 T25449 auxpass was,used
R19752 T25449 T25449 ROOT used,used
R19753 T25450 T25449 prep as,used
R19754 T25451 T25453 det a,control
R19755 T25452 T25453 compound loading,control
R19756 T25453 T25450 pobj control,as
R19757 T25454 T25449 punct .,used
R19778 T25521 T25521 ROOT Summary,Summary
R19779 T25522 T25521 prep of,Summary
R19780 T25523 T25522 pobj Analysis,of
R19781 T25524 T25521 npadvmod Performed,Summary
R19782 T25525 T25524 prep on,Performed
R19783 T25526 T25525 pobj Wild-Type,on
R19784 T25527 T25526 cc and,Wild-Type
R19785 T25528 T25530 compound LMP1,Lymphomas
R19786 T25529 T25530 compound Transgenic,Lymphomas
R12485 T16301 T16302 nummod 20,]
R12486 T16302 T16296 appos ],expansion
R12487 T16303 T16293 punct .,contribute
R12488 T16304 T16305 nsubj It,is
R12489 T16305 T16305 ROOT is,is
R12490 T16306 T16305 acomp noteworthy,is
R12497 T16313 T16311 pobj mice,in
R12498 T16314 T16316 aux has,shown
R12499 T16315 T16316 auxpass been,shown
R12500 T16316 T16305 ccomp shown,is
R12501 T16317 T16318 aux to,inhibit
R12502 T16318 T16316 xcomp inhibit,shown
R12503 T16319 T16320 det the,formation
R12504 T16320 T16318 dobj formation,inhibit
R12505 T16321 T16320 prep of,formation
R12506 T16322 T16323 compound GCs,[
R12507 T16323 T16325 compound [,]
R12508 T16324 T16325 compound "23,49",]
R12509 T16325 T16321 pobj ],of
R12510 T16326 T16318 punct ",",inhibit
R12511 T16327 T16316 advcl preventing,shown
R12512 T16328 T16330 amod typical,cells
R12513 T16329 T16330 compound B-2,cells
R12514 T16330 T16327 dobj cells,preventing
R12515 T16331 T16327 prep from,preventing
R12516 T16332 T16333 compound antigen-driven,selection
R12517 T16333 T16331 pobj selection,from
R12518 T16334 T16333 cc and,selection
R12519 T16335 T16333 conj expansion,selection
R12520 T16336 T16305 punct .,is
R12521 T16337 T16338 det The,lack
R12522 T16338 T16343 nsubj lack,contribute
R12523 T16339 T16338 prep of,lack
R12524 T16340 T16341 compound GC,reactions
R12525 T16341 T16339 pobj reactions,of
R12526 T16342 T16343 aux may,contribute
R12527 T16343 T16343 ROOT contribute,contribute
R12528 T16344 T16343 prep to,contribute
R12529 T16345 T16346 det the,bias
R12530 T16346 T16344 pobj bias,to
R12531 T16347 T16346 prep of,bias
R12533 T16349 T16350 amod transgenic,mice
R12534 T16350 T16347 pobj mice,of
R12535 T16351 T16346 prep towards,bias
R12536 T16352 T16354 amod B-1,lymphomas
R12537 T16353 T16354 compound cell,lymphomas
R12538 T16354 T16351 pobj lymphomas,towards
R12539 T16355 T16343 punct .,contribute
R12540 T16356 T16361 advmod Interestingly,favors
R12541 T16357 T16361 punct ",",favors
R12542 T16358 T16359 compound LMP2,signaling
R12543 T16359 T16361 nsubj signaling,favors
R12544 T16360 T16361 advmod also,favors
R12545 T16361 T16361 ROOT favors,favors
R12546 T16362 T16361 dobj development,favors
R12547 T16363 T16362 prep of,development
R12548 T16364 T16365 compound B-1,cells
R12549 T16365 T16363 pobj cells,of
R12550 T16366 T16361 punct ",",favors
R12551 T16367 T16361 cc but,favors
R12552 T16368 T16369 nsubj this,occurs
R12553 T16369 T16361 conj occurs,favors
R12554 T16370 T16369 prep in,occurs
R12750 T16566 T16565 prep to,predisposed
R12751 T16567 T16566 pobj transformation,to
R12752 T16568 T16570 compound [,]
R12753 T16569 T16570 compound "28,29",]
R12754 T16570 T16567 appos ],transformation
R12755 T16571 T16555 punct .,have
R12756 T16572 T16573 amod Clonal,expansion
R15830 T20283 T20284 compound Becton,Dickinson
R15831 T20284 T20281 appos Dickinson,program
R15832 T20285 T20281 punct ),program
R15833 T20286 T20275 punct .,performed
R15834 T20287 T20288 amod Further,analysis
R17875 T22874 T22875 nsubj Splenocytes,were
R17876 T22875 T22875 ROOT were,were
R17877 T22876 T22875 acomp cultured,were
R17878 T22877 T22876 prep in,cultured
R17879 T22878 T22879 det the,presence
R17880 T22879 T22877 pobj presence,in
R17881 T22880 T22882 punct (,bars
R17882 T22881 T22882 amod grey,bars
R17883 T22882 T22879 appos bars,presence
R17884 T22883 T22882 punct ),bars
R17885 T22884 T22882 cc or,bars
R12453 T16269 T16265 punct ",",numbers
R12454 T16270 T16271 det a,phenotype
R12455 T16271 T16265 conj phenotype,numbers
R12456 T16272 T16271 acl associated,phenotype
R12457 T16273 T16272 prep with,associated
R12458 T16274 T16277 amod B-1,zone
R12459 T16275 T16277 punct ",",zone
R12460 T16276 T16277 amod marginal,zone
R12461 T16277 T16273 pobj zone,with
R12462 T16278 T16277 punct ",",zone
R12463 T16279 T16277 cc and,zone
R12464 T16280 T16282 compound memory,cells
R12465 T16281 T16282 compound B,cells
R12467 T16283 T16271 punct ",",phenotype
R12468 T16284 T16285 det the,mimicry
R12469 T16285 T16293 nsubj mimicry,contribute
R12470 T16286 T16285 prep of,mimicry
R12471 T16287 T16286 pobj CD40,of
R12472 T16288 T16285 acl signaling,mimicry
R12473 T16289 T16288 prep by,signaling
R12474 T16290 T16289 pobj LMP1,by
R12475 T16291 T16293 aux could,contribute
R12476 T16292 T16293 advmod possibly,contribute
R12477 T16293 T16293 ROOT contribute,contribute
R12478 T16294 T16293 prep to,contribute
R12479 T16295 T16296 det the,expansion
R12480 T16296 T16294 pobj expansion,to
R12481 T16297 T16296 prep of,expansion
R12482 T16298 T16299 compound B-1,cells
R12483 T16299 T16297 pobj cells,of
R12484 T16300 T16302 nmod [,]
R12532 T16348 T16350 nummod LMP1,mice
R12757 T16573 T16579 nsubjpass expansion,detected
R12758 T16574 T16573 prep of,expansion
R12759 T16575 T16576 compound B-1,cells
R12760 T16576 T16574 pobj cells,of
R12761 T16577 T16579 aux can,detected
R12762 T16578 T16579 auxpass be,detected
R12763 T16579 T16579 ROOT detected,detected
R12764 T16580 T16579 prep in,detected
R12765 T16581 T16582 amod aging,mice
R12766 T16582 T16580 pobj mice,in
R12767 T16583 T16579 prep above,detected
R12768 T16584 T16585 nummod 18,mo
R13388 T17226 T17228 compound [,]
R13393 T17227 T17228 nummod "49,70",]
R13397 T17228 T17221 appos ],factor
R13398 T17211 T17212 amod PI3K-dependent,manner
R13399 T17212 T17209 pobj manner,in
R13400 T17213 T17214 aux can,inhibit
R14973 T19323 T19322 punct ",",4
R14974 T19324 T19322 amod 5-dimethylthiazol-2-yl,4
R14975 T19325 T19322 punct ),4
R14976 T19326 T19322 punct -5,4
R14977 T19327 T19322 punct -,4
R14978 T19328 T19329 punct (,3-carboxymethoxyphenyl
R14979 T19329 T19322 appos 3-carboxymethoxyphenyl,4
R14980 T19330 T19322 punct ),4
R14981 T19331 T19322 punct -2,4
R14982 T19332 T19331 punct -,-2
R14983 T19333 T19331 punct (,-2
R14984 T19334 T19331 appos 4-sulfophenyl,-2
R14985 T19335 T19331 punct ),-2
R14986 T19336 T19339 nummod -2,salt
R14987 T19337 T19339 nmod H-tetrazolium,salt
R14988 T19338 T19339 amod inner,salt
R14989 T19339 T19345 nmod salt,assays
R14990 T19340 T19341 punct (,MTS
R14991 T19341 T19345 nmod MTS,assays
R14992 T19342 T19341 punct ),MTS
R14993 T19343 T19345 compound cell,assays
R14994 T19344 T19345 compound cytotoxicity/proliferation,assays
R14995 T19345 T19347 nsubjpass assays,performed
R14996 T19346 T19347 auxpass were,performed
R14997 T19347 T19347 ROOT performed,performed
R14998 T19348 T19347 advcl using,performed
R14999 T19349 T19356 det the,assay
R15000 T19350 T19355 nmod CellTiter,proliferation
R15001 T19351 T19352 nummod 96,aqueous
R15002 T19352 T19355 nmod aqueous,proliferation
R15003 T19353 T19355 amod one-solution,proliferation
R15100 T19450 T19449 pobj day,on
R15101 T19451 T19450 prep of,day
R15102 T19452 T19451 pobj harvest,of
R15103 T19453 T19452 cc and,harvest
R15104 T19454 T19452 conj IL4,harvest
R15105 T19455 T19454 punct ",",IL4
R15106 T19456 T19459 compound rat,IL4
R15107 T19457 T19459 compound IgG1,IL4
R15108 T19458 T19459 compound anti-mouse,IL4
R15109 T19459 T19454 conj IL4,IL4
R15110 T19460 T19459 punct ",",IL4
R15111 T19461 T19459 cc or,IL4
R15112 T19462 T19465 nmod rat,control
R15113 T19463 T19465 amod IgG1,control
R15114 T19464 T19465 compound isotype,control
R15115 T19465 T19459 conj control,IL4
R15116 T19466 T19468 punct (,Systems
R15117 T19467 T19468 compound R&D,Systems
R15118 T19468 T19465 appos Systems,control
R15119 T19469 T19438 punct ),seeded
R15120 T19470 T19471 auxpass were,added
R15121 T19471 T19475 csubj added,indicated
R15122 T19472 T19471 prep at,added
R15123 T19473 T19474 det the,concentrations
R15124 T19474 T19472 pobj concentrations,at
R15125 T19475 T19438 dep indicated,seeded
R15126 T19476 T19475 prep in,indicated
R15127 T19477 T19478 det the,figures
R15128 T19478 T19476 pobj figures,in
R15129 T19479 T19475 punct .,indicated
R15130 T19480 T19482 nsubjpass Cultures,pulsed
R15131 T19481 T19482 auxpass were,pulsed
R15132 T19482 T19482 ROOT pulsed,pulsed
R15133 T19483 T19482 prep for,pulsed
R15134 T19484 T19485 nummod 4,h
R15135 T19485 T19483 pobj h,for
R15136 T19486 T19485 prep with,h
R15137 T19487 T19488 compound MTS,reagent
R15138 T19488 T19486 pobj reagent,with
R15139 T19489 T19488 nummod 1,reagent
R15140 T19490 T19491 meta d,post-seeding
R15141 T19491 T19491 ROOT post-seeding,post-seeding
R15142 T19492 T19491 punct .,post-seeding
R15143 T19493 T19499 prep For,seeded
R15144 T19494 T19495 compound inhibitor,studies
R15145 T19495 T19493 pobj studies,For
R15146 T19496 T19499 punct ",",seeded
R15147 T19497 T19499 nsubjpass splenocytes,seeded
R15207 T19557 T19558 auxpass was,induced
R15521 T19934 T19933 punct (,IgG
R15522 T19935 T19933 appos H+L,IgG
R15523 T19936 T19933 punct ),IgG
R15524 T19937 T19922 conj pre-adsorbed,μg
R15525 T19938 T19939 aux to,mouse
R15526 T19939 T19940 compound mouse,serum
R15527 T19940 T19920 pobj serum,with
R15528 T19941 T19940 punct (,serum
R15529 T19942 T19943 compound Jackson,ImmunoResearch
R15758 T20211 T20213 nsubjpass kit,used
R15759 T20212 T20213 auxpass was,used
R15760 T20213 T20213 ROOT used,used
R15761 T20214 T20215 mark as,instructed
R15762 T20215 T20213 advcl instructed,used
R15763 T20216 T20215 agent by,instructed
R15764 T20217 T20218 det the,manufacturer
R15765 T20218 T20216 pobj manufacturer,by
R15766 T20219 T20221 punct (,Bioscience
R15767 T20220 T20221 compound BD,Bioscience
R15768 T20221 T20218 appos Bioscience,manufacturer
R15769 T20222 T20213 punct ),used
R15770 T20223 T20213 punct .,used
R15771 T20224 T20228 advmod Briefly,exposed
R15772 T20225 T20228 punct ",",exposed
R15773 T20226 T20228 nsubjpass cells,exposed
R15774 T20227 T20228 auxpass were,exposed
R15775 T20228 T20228 ROOT exposed,exposed
R15776 T20229 T20228 prep to,exposed
R15777 T20230 T20229 pobj EMA,to
R15778 T20231 T20233 punct (,Probes
R15779 T20232 T20233 compound Molecular,Probes
R15780 T20233 T20230 appos Probes,EMA
R15781 T20234 T20228 punct ),exposed
R15782 T20235 T20228 prep for,exposed
R15783 T20236 T20235 pobj exclusion,for
R15812 T20265 T20262 cc and,treated
R15813 T20266 T20262 conj stained,treated
R15814 T20267 T20266 prep with,stained
R15818 T20271 T20262 punct .,treated
R15819 T20272 T20273 compound Flow,cytometry
R15820 T20273 T20275 nsubjpass cytometry,performed
R15821 T20274 T20275 auxpass was,performed
R15822 T20275 T20275 ROOT performed,performed
R15823 T20276 T20275 prep on,performed
R15824 T20277 T20276 pobj FACScalibur,on
R15825 T20278 T20275 advcl using,performed
R15826 T20279 T20281 det the,program
R15827 T20280 T20281 compound CellQuest,program
R15828 T20281 T20278 dobj program,using
R15829 T20282 T20281 punct (,program
R15835 T20288 T20290 nsubjpass analysis,conducted
R15836 T20289 T20290 auxpass was,conducted
R15837 T20290 T20290 ROOT conducted,conducted
R15838 T20291 T20290 prep on,conducted
R15839 T20292 T20296 det the,program
R15840 T20293 T20296 nmod Summit,program
R15841 T20294 T20296 nummod v4,program
R16737 T21286 T21286 ROOT determined,determined
R16738 T21287 T21286 prep with,determined
R16739 T21288 T21293 det the,system
R16740 T21289 T21290 compound Bio-Rad,DC
R16741 T21290 T21293 compound DC,system
R16742 T21291 T21293 compound protein,system
R16743 T21292 T21293 compound assay,system
R16744 T21293 T21287 pobj system,with
R16745 T21294 T21286 punct .,determined
R16746 T21295 T21297 nsubjpass Lysates,boiled
R16747 T21296 T21297 auxpass were,boiled
R16826 T21486 T21510 dep clone,PE-conjugated
R16827 T21487 T21486 nummod 11,clone
R16828 T21488 T21486 appos 26,clone
R16829 T21489 T21486 punct ),clone
R16830 T21490 T21486 punct ",",clone
R16831 T21491 T21486 intj rat,clone
R17872 T22871 T22872 amod transgenic,mice
R17873 T22872 T22867 pobj mice,from
R17874 T22873 T22864 punct .,assay
R18307 T23436 T23434 pobj pStat6,for
R18360 T23489 T23481 punct .,indicates
R18361 T23490 T23496 punct (,assay
R18362 T23491 T23496 nmod D,assay
R18363 T23492 T23491 cc and,D
R18364 T23493 T23491 conj E,D
R18365 T23494 T23496 punct ),assay
R18366 T23495 T23496 compound MTS,assay
R18367 T23496 T23496 ROOT assay,assay
R18368 T23497 T23496 prep of,assay
R18369 T23498 T23499 punct (,D
R18370 T23499 T23497 pobj D,of
R18371 T23500 T23499 punct ),D
R18372 T23501 T23502 compound WT,lymphocytes
R18373 T23502 T23496 dobj lymphocytes,assay
R18374 T23503 T23502 cc and,lymphocytes
R18375 T23504 T23505 punct (,E
R18376 T23505 T23502 conj E,lymphocytes
R18377 T23506 T23505 punct ),E
R18426 T23555 T23556 compound representative,experiment
R18427 T23556 T23552 pobj experiment,from
R18428 T23557 T23559 nsubjpass that,repeated
R18429 T23558 T23559 auxpass was,repeated
R18430 T23559 T23556 relcl repeated,experiment
R18431 T23560 T23559 advmod twice,repeated
R18432 T23561 T23559 prep with,repeated
R18433 T23562 T23563 amod similar,results
R18434 T23563 T23561 pobj results,with
R18435 T23564 T23544 punct .,are
R18672 T23961 T23961 ROOT LMP1,LMP1
R18673 T23962 T23967 nsubj Upregulates,Activates
R18674 T23963 T23964 compound IL10,Expression
R18675 T23964 T23967 nsubj Expression,Activates
R18680 T23969 T23970 punct (,A
R18681 T23970 T23968 appos A,Stat3
R18682 T23971 T23970 punct ),A
R18683 T23972 T23973 amod Relative,expression
R18684 T23973 T23968 appos expression,Stat3
R18685 T23974 T23973 prep of,expression
R18686 T23975 T23974 pobj IL10,of
R18687 T23976 T23975 punct ",",IL10
R18688 T23977 T23975 conj IL15,IL10
R18689 T23978 T23977 punct ",",IL15
R18690 T23979 T23977 cc and,IL15
R18691 T23980 T23981 compound IFNγ,mRNA
R18692 T23981 T23977 conj mRNA,IL15
R18693 T23982 T23981 prep in,mRNA
R18694 T23983 T23988 nmod WT,cells
R18695 T23984 T23983 cc and,WT
R18696 T23985 T23983 conj LMP1,WT
R18697 T23986 T23988 amod transgenic,cells
R18698 T23987 T23988 compound B,cells
R18699 T23988 T23982 pobj cells,in
R18700 T23989 T23991 punct (,+
R18701 T23990 T23991 nummod CD19,+
R18702 T23991 T23988 appos +,cells
R18703 T23992 T23981 punct ),mRNA
R18704 T23993 T23968 punct ",",Stat3
R18705 T23994 T23995 mark as,detected
R18706 T23995 T23967 advcl detected,Activates
R18707 T23996 T23995 prep with,detected
R18708 T23997 T24000 det an,assay
R18709 T23998 T24000 amod Rnase,assay
R18710 T23999 T24000 compound protection,assay
R18711 T24000 T23996 pobj assay,with
R18712 T24001 T23967 punct .,Activates
R18713 T24002 T24005 compound Mouse,lines
R18714 T24003 T24005 compound lymphoma,lines
R18715 T24004 T24005 compound cell,lines
R18716 T24005 T24010 nsubjpass lines,used
R18717 T24006 T24005 appos 967,lines
R18718 T24007 T24006 cc and,967
R18719 T24008 T24006 conj K46μ,967
R18720 T24009 T24010 auxpass were,used
R18721 T24010 T24010 ROOT used,used
R18722 T24011 T24010 prep as,used
R18723 T24012 T24011 pobj controls,as
R18724 T24013 T24010 punct .,used
R18725 T24014 T24015 compound Expression,levels
R18726 T24015 T24017 nsubjpass levels,quantified
R18727 T24016 T24017 auxpass were,quantified
R18728 T24017 T24017 ROOT quantified,quantified
R18729 T24018 T24017 prep with,quantified
R18730 T24019 T24020 det a,phosphorimager
R18731 T24020 T24018 pobj phosphorimager,with
R18732 T24021 T24020 cc and,phosphorimager
R18733 T24022 T24023 nsubj values,were
R18734 T24023 T24023 ROOT were,were
R18735 T24024 T24023 acomp normalized,were
R18736 T24025 T24024 prep to,normalized
R18737 T24026 T24029 det the,gene
R18738 T24027 T24029 amod ribosomal,gene
R18739 T24028 T24029 compound housekeeping,gene
R18740 T24029 T24025 pobj gene,to
R18741 T24030 T24029 appos L32,gene
R18742 T24031 T24023 punct .,were
R18743 T24032 T24033 det The,cytokine
R18744 T24033 T24038 nsubjpass cytokine,set
R18745 T24034 T24033 punct :,cytokine
R18746 T24035 T24036 nummod L32,ratio
R18750 T24039 T24038 prep to,set
R18751 T24040 T24039 pobj 1,to
R18752 T24041 T24040 prep in,1
R18753 T24042 T24045 det the,cell
R18754 T24043 T24045 compound mouse,cell
R18755 T24044 T24045 compound B,cell
R18756 T24045 T24046 compound cell,lymphoma
R18757 T24046 T24047 compound lymphoma,line
R18758 T24047 T24041 pobj line,in
R18759 T24048 T24047 nummod 967,line
R18760 T24049 T24038 punct .,set
R18761 T24050 T24056 punct (,analysis
R18762 T24051 T24056 nmod B,analysis
R18763 T24052 T24051 cc and,B
R18764 T24053 T24051 conj C,B
R18765 T24054 T24051 punct ),B
R18766 T24055 T24056 compound Immunoblot,analysis
R18767 T24056 T24056 ROOT analysis,analysis
R18768 T24057 T24056 prep of,analysis
R18769 T24058 T24059 amod activated,pStat3
R18770 T24059 T24057 pobj pStat3,of
R18771 T24060 T24059 prep in,pStat3
R18772 T24061 T24063 amod purified,cells
R18773 T24062 T24063 compound B,cells
R18774 T24063 T24060 pobj cells,in
R18775 T24064 T24063 punct (,cells
R18776 T24065 T24066 nummod CD19,+
R18777 T24066 T24063 appos +,cells
R18778 T24067 T24063 punct ),cells
R18779 T24068 T24059 prep from,pStat3
R18780 T24069 T24073 nmod WT,mice
R18781 T24070 T24069 cc and,WT
R18782 T24071 T24069 conj LMP1,WT
R18783 T24072 T24073 amod transgenic,mice
R18784 T24073 T24068 pobj mice,from
R18785 T24074 T24075 punct (,B
R18786 T24075 T24073 appos B,mice
R18787 T24076 T24073 punct ),mice
R18788 T24077 T24056 prep at,analysis
R18791 T24080 T24079 prep of,time
R18875 T24164 T24159 pobj mice,of
R18876 T24165 T24151 punct .,detection
R18877 T24166 T24167 compound Scale,bar
R18878 T24167 T24167 ROOT bar,bar
R18879 T24168 T24167 punct ",",bar
R18880 T24169 T24170 nummod 20,μm
R18881 T24170 T24167 appos μm,bar
R18882 T24171 T24167 punct .,bar
R19064 T24520 T24520 ROOT LMP1,LMP1
R19065 T24521 T24522 compound Activates,Akt
R19066 T24522 T24564 npadvmod Akt,activated
R19067 T24523 T24525 amod Signaling,Deregulates
R19068 T24524 T24523 cc and,Signaling
R19069 T24525 T24564 dep Deregulates,activated
R19070 T24526 T24530 det the,Pathway
R19071 T24527 T24530 compound Rb,Pathway
R19072 T24528 T24529 compound Cell,Cycle
R19073 T24529 T24530 compound Cycle,Pathway
R19074 T24530 T24525 dobj Pathway,Deregulates
R19075 T24531 T24532 punct (,A
R19076 T24532 T24525 appos A,Deregulates
R19077 T24533 T24532 cc and,A
R19078 T24534 T24537 nmod B,analysis
R19787 T25530 T25526 conj Lymphomas,Wild-Type
R167 T255 T256 compound Membrane,Protein
R168 T256 T276 nsubj Protein,is
R169 T257 T256 nummod 1,Protein
R170 T258 T259 compound Activates,Akt
R171 T259 T256 npadvmod Akt,Protein
R172 T260 T259 punct ",",Akt
R173 T261 T259 conj NFκB,Akt
R174 T262 T261 punct ",",NFκB
R175 T263 T261 cc and,NFκB
R176 T264 T261 conj Stat3,NFκB
R177 T265 T259 prep in,Akt
R178 T266 T271 compound B,protein
R179 T267 T268 compound Cell,Lymphomas
R180 T268 T271 compound Lymphomas,protein
R181 T269 T271 compound Latent,protein
R182 T270 T271 compound membrane,protein
R183 T271 T265 pobj protein,in
R184 T272 T271 nummod 1,protein
R185 T273 T271 punct (,protein
R186 T274 T271 appos LMP1,protein
R358 T253 T256 compound EBV,Protein
R359 T254 T256 compound Latent,Protein
R5402 T6929 T6927 pobj d,at
R5192 T6719 T6727 nsubj wild-type,Require
R5193 T6720 T6719 cc and,wild-type
R5194 T6721 T6724 compound LMP1,Cells
R5195 T6722 T6724 compound transgenic,Cells
R5196 T6723 T6724 compound lymphoma,Cells
R5197 T6724 T6719 conj Cells,wild-type
R5198 T6725 T6727 aux Do,Require
R5199 T6726 T6727 neg Not,Require
R5200 T6727 T6727 ROOT Require,Require
R5201 T6728 T6727 dobj IL4,Require
R5202 T6729 T6728 cc and,IL4
R5203 T6730 T6731 compound Stat6,Signaling
R5204 T6731 T6728 conj Signaling,IL4
R5205 T6732 T6733 aux To,investigate
R5206 T6733 T6727 xcomp investigate,Require
R5207 T6734 T6737 mark whether,was
R5208 T6735 T6736 compound IL4,independence
R5209 T6736 T6737 nsubj independence,was
R5210 T6737 T6747 advcl was,assessed
R5211 T6738 T6742 amod due,expression
R5212 T6739 T6740 aux to,endogenous
R5213 T6740 T6742 amod endogenous,expression
R5214 T6741 T6742 compound IL4,expression
R5215 T6742 T6737 attr expression,was
R5216 T6743 T6747 punct ",",assessed
R5217 T6744 T6745 compound IL4,transcription
R5218 T6745 T6747 nsubjpass transcription,assessed
R5481 T7008 T7000 conj require,grew
R6906 T8812 T8810 pobj antibody,with
R8182 T10702 T10701 dobj Akt,activated
R8118 T10638 T10639 amod transgenic,lymphocytes
R8119 T10639 T10636 pobj lymphocytes,in
R8120 T10640 T10635 cc and,detected
R8121 T10641 T10643 auxpass was,absent
R8122 T10642 T10643 advmod almost,absent
R8123 T10643 T10635 conj absent,detected
R8124 T10644 T10643 prep in,absent
R8125 T10645 T10647 det the,samples
R8126 T10646 T10647 compound lymphoma,samples
R8127 T10647 T10644 pobj samples,in
R8128 T10648 T10650 punct (,6A
R8129 T10649 T10650 compound Figure,6A
R8130 T10650 T10647 appos 6A,samples
R8131 T10651 T10643 punct ),absent
R8132 T10652 T10630 punct .,increased
R8351 T10871 T10870 dobj pathway,signaling
R8352 T10872 T10864 ccomp is,suggesting
R8353 T10873 T10875 det an,target
R8354 T10874 T10875 amod important,target
R8355 T10875 T10872 attr target,is
R8356 T10876 T10875 prep of,target
R8357 T10877 T10876 pobj Akt,of
R8358 T10878 T10875 prep in,target
R8359 T10879 T10880 compound lymphoma,development
R8360 T10880 T10878 pobj development,in
R8361 T10881 T10845 punct .,indicated
R8362 T10882 T10902 advmod However,be
R8363 T10883 T10902 punct ",",be
R8364 T10884 T10902 advcl considering,be
R8365 T10885 T10887 det that,activation
R8366 T10886 T10887 compound Akt,activation
R8367 T10887 T10890 nsubj activation,induce
R8368 T10888 T10890 aux did,induce
R8369 T10889 T10890 neg not,induce
R8370 T10890 T10884 ccomp induce,considering
R8371 T10891 T10892 amod FoxO1,degradation
R8372 T10892 T10890 dobj degradation,induce
R8373 T10893 T10892 prep in,degradation
R8374 T10894 T10897 nummod LMP1,cells
R8375 T10895 T10897 amod transgenic,cells
R8376 T10896 T10897 compound B,cells
R8377 T10897 T10893 pobj cells,in
R8378 T10898 T10902 punct ",",be
R8379 T10899 T10902 nsubj Akt,be
R8380 T10900 T10902 aux may,be
R8381 T10901 T10902 neg not,be
R8382 T10902 T10902 ROOT be,be
R8383 T10903 T10905 det the,regulator
R8384 T10904 T10905 amod sole,regulator
R8385 T10905 T10902 attr regulator,be
R8386 T10906 T10905 prep of,regulator
R8387 T10907 T10906 pobj FoxO1,of
R8388 T10908 T10902 punct ",",be
R8389 T10909 T10902 cc and,be
R8390 T10910 T10912 nsubj it,be
R8391 T10911 T10912 aux may,be
R8430 T10950 T10949 prep of,expression
R8431 T10951 T10950 pobj p27,of
R8432 T10952 T10948 punct ",",decreased
R8433 T10953 T10948 npadvmod upregulation,decreased
R8434 T10954 T10953 prep of,upregulation
R8435 T10955 T10954 pobj Cdk2,of
R8436 T10956 T10953 punct ",",upregulation
R8437 T10957 T10953 cc and,upregulation
R8438 T10958 T10959 amod subsequent,phosphorylation
R8439 T10959 T10953 conj phosphorylation,upregulation
R8440 T10960 T10959 cc and,phosphorylation
R8441 T10961 T10959 conj inactivation,phosphorylation
R8442 T10962 T10959 prep of,phosphorylation
R8443 T10963 T10966 det the,gene
R8444 T10964 T10966 compound tumor,gene
R8445 T10965 T10966 compound suppressor,gene
R8446 T10966 T10970 nmod gene,]
R8447 T10967 T10968 compound Rb,[
R8448 T10968 T10966 appos [,gene
R8449 T10969 T10970 nummod 45,]
R8450 T10970 T10962 pobj ],of
R10016 T13108 T13109 nsubj This,is
R10017 T13109 T13109 ROOT is,is
R10018 T13110 T13111 advmod well,within
R10019 T13111 T13109 prep within,is
R10020 T13112 T13114 det the,IC50
R10021 T13113 T13114 amod reported,IC50
R10022 T13114 T13111 pobj IC50,within
R10023 T13115 T13114 prep of,IC50
R10024 T13116 T13117 nummod 10,μM
R10025 T13117 T13115 pobj μM,of
R10026 T13118 T13109 punct .,is
R10027 T13119 T13120 compound Phosphorylated,Akt
R10028 T13120 T13127 nsubj Akt,were
R10029 T13121 T13120 punct ",",Akt
R10030 T13122 T13120 conj Stat3,Akt
R10031 T13123 T13122 punct ",",Stat3
R10032 T13124 T13122 cc and,Stat3
R10033 T13125 T13126 amod total,IκBα
R10034 T13126 T13122 conj IκBα,Stat3
R10035 T13127 T13127 ROOT were,were
R10036 T13128 T13127 advmod still,were
R10037 T13129 T13127 acomp present,were
R10038 T13130 T13129 prt up,present
R10172 T13264 T13265 amod higher,doses
R10173 T13265 T13263 pobj doses,at
R10174 T13266 T13268 det all,levels
R10175 T13267 T13268 compound protein,levels
R10176 T13268 T13271 nsubjpass levels,decreased
R10177 T13269 T13271 auxpass were,decreased
R10178 T13270 T13271 advmod greatly,decreased
R10179 T13271 T13256 conj decreased,were
R10180 T13272 T13271 punct ",",decreased
R10181 T13273 T13271 advcl indicative,decreased
R10182 T13274 T13273 prep of,indicative
R10183 T13275 T13277 det the,loss
R10184 T13276 T13277 amod total,loss
R10185 T13277 T13274 pobj loss,of
R10186 T13278 T13277 prep of,loss
R10187 T13279 T13278 pobj viability,of
R10188 T13280 T13281 punct (,Figure
R10189 T13281 T13277 appos Figure,loss
R10190 T13282 T13281 nummod 8,Figure
R10191 T13283 T13281 punct ),Figure
R10192 T13284 T13271 punct .,decreased
R10193 T13285 T13287 det A,reported
R10228 T13320 T13318 parataxis Figure,affected
R10229 T13321 T13320 nummod 8,Figure
R10230 T13322 T13320 punct ),Figure
R10231 T13323 T13315 punct .,were
R10232 T13324 T13325 det These,findings
R10233 T13325 T13326 nsubj findings,suggest
R10234 T13326 T13326 ROOT suggest,suggest
R10235 T13327 T13332 mark that,induce
R10236 T13328 T13332 nsubj inhibition,induce
R10237 T13329 T13328 prep of,inhibition
R10238 T13330 T13329 pobj Stat3,of
R10239 T13331 T13332 aux can,induce
R10240 T13332 T13326 ccomp induce,suggest
R10241 T13333 T13334 compound cell,death
R10242 T13334 T13332 dobj death,induce
R10243 T13335 T13332 prep in,induce
R10244 T13336 T13338 nummod LMP1,lymphocytes
R10245 T13337 T13338 amod transgenic,lymphocytes
R10246 T13338 T13335 pobj lymphocytes,in
R10247 T13339 T13338 cc and,lymphocytes
R10248 T13340 T13341 compound lymphoma,cells
R10250 T13342 T13332 punct ",",induce
R10251 T13343 T13326 cc but,suggest
R10252 T13344 T13345 amod Stat3,inhibition
R10253 T13345 T13347 nsubj inhibition,has
R10254 T13346 T13347 advmod also,has
R10255 T13347 T13326 conj has,suggest
R10256 T13348 T13350 amod considerable,effects
R10257 T13349 T13350 amod crossover,effects
R10258 T13350 T13347 dobj effects,has
R10259 T13351 T13350 prep on,effects
R10260 T13352 T13351 pobj Akt,on
R10261 T13353 T13352 cc and,Akt
R10262 T13354 T13352 conj NFκB,Akt
R10263 T13355 T13350 acl signaling,effects
R10264 T13356 T13347 punct .,has
R10265 T13357 T13361 nsubjpass LMP1,shown
R10266 T13358 T13361 aux has,shown
R10267 T13359 T13361 advmod also,shown
R10268 T13360 T13361 auxpass been,shown
R10269 T13361 T13361 ROOT shown,shown
R10270 T13362 T13363 aux to,activate
R10271 T13363 T13361 xcomp activate,shown
R10272 T13364 T13363 dobj JNK,activate
R10306 T13398 T13397 prep of,inhibitor
R10307 T13399 T13400 compound MEK1/2,activity
R10308 T13400 T13398 pobj activity,of
R10309 T13401 T13377 punct .,were
R10310 T13402 T13407 advmod However,were
R10311 T13403 T13407 punct ",",were
R10312 T13404 T13407 nsubj effects,were
R10313 T13405 T13404 prep of,effects
R10314 T13406 T13405 pobj SB202190,of
R10315 T13407 T13407 ROOT were,were
R10316 T13408 T13409 advmod only,apparent
R10317 T13409 T13407 acomp apparent,were
R10318 T13410 T13409 prep at,apparent
R10319 T13411 T13412 amod high,doses
R10320 T13412 T13410 pobj doses,at
R10321 T13413 T13412 punct (,doses
R10322 T13414 T13412 appos >,doses
R10323 T13415 T13416 nummod 10,μM
R10324 T13416 T13414 nmod μM,>
R10325 T13417 T13412 punct ),doses
R10326 T13418 T13407 punct ",",were
R10327 T13419 T13420 advmod much,higher
R10407 T13499 T13485 ccomp are,suggesting
R10408 T13500 T13499 attr characteristics,are
R10409 T13501 T13500 acl associated,characteristics
R10410 T13502 T13501 prep with,associated
R10411 T13503 T13504 amod malignant,transformation
R10412 T13504 T13502 pobj transformation,with
R10413 T13505 T13506 punct (,Figure
R10414 T13506 T13504 appos Figure,transformation
R10415 T13507 T13506 nummod 7,Figure
R10416 T13508 T13506 punct ),Figure
R10417 T13509 T13461 punct .,were
R10418 T13510 T13519 nsubj rapamycin,affect
R10419 T13511 T13510 punct ",",rapamycin
R10420 T13512 T13513 det an,inhibitor
R10421 T13513 T13510 appos inhibitor,rapamycin
R10422 T13514 T13513 prep of,inhibitor
R10423 T13515 T13514 pobj mTOR,of
R10424 T13516 T13519 punct ",",affect
R10425 T13517 T13519 aux did,affect
R10426 T13518 T13519 neg not,affect
R10427 T13519 T13519 ROOT affect,affect
R10428 T13520 T13521 det the,viability
R10429 T13521 T13519 dobj viability,affect
R10430 T13522 T13521 prep of,viability
R10431 T13523 T13525 det the,lymphocytes

UBERON-AE

Id Subject Object Predicate Lexical cue
T687 3850-3865 http://purl.obolibrary.org/obo/UBERON_0010754 denotes germinal center
T3153 7028-7035 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleens
T3154 7619-7625 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T3155 7714-7720 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T7420 24052-24058 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T14338 36530-36536 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T14339 36538-36543 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
T14340 36538-36548 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph node
T14341 36565-36570 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T14342 36635-36640 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T18283 42791-42795 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T18284 42841-42846 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T18285 43144-43151 http://purl.obolibrary.org/obo/UBERON_0000916 denotes abdomen
T18601 43474-43480 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T18602 43481-43487 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T18603 43887-43892 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T19635 45893-45899 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T19636 46352-46358 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T19637 46470-46475 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T20766 48701-48707 http://purl.obolibrary.org/obo/UBERON_0000479 denotes Tissue
T21795 8659-8665 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T21796 8666-8672 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T23703 23856-23863 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleens
T24343 25861-25868 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleens

GO-BP

Id Subject Object Predicate Lexical cue
T67 281-292 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T68 305-308 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T69 862-865 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T70 476-486 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T71 668-677 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T72 750-759 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T807 1851-1854 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T808 6453-6456 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T809 1945-1956 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T810 2373-2384 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T811 4719-4730 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T812 5049-5060 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T813 5558-5569 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T814 2274-2280 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T815 2329-2335 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T816 2550-2556 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T817 5315-5321 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T818 6202-6208 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T819 6314-6320 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T820 6646-6652 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T821 2324-2335 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T822 2545-2556 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T823 2324-2346 http://purl.obolibrary.org/obo/GO_0030308 denotes cell growth regulation
T824 2545-2567 http://purl.obolibrary.org/obo/GO_0030308 denotes cell growth regulation
T825 2324-2346 http://purl.obolibrary.org/obo/GO_0061387 denotes cell growth regulation
T826 2545-2567 http://purl.obolibrary.org/obo/GO_0061387 denotes cell growth regulation
T827 2324-2346 http://purl.obolibrary.org/obo/GO_0061388 denotes cell growth regulation
T828 2545-2567 http://purl.obolibrary.org/obo/GO_0061388 denotes cell growth regulation
T829 2324-2346 http://purl.obolibrary.org/obo/GO_0051513 denotes cell growth regulation
T830 2545-2567 http://purl.obolibrary.org/obo/GO_0051513 denotes cell growth regulation
T831 2324-2346 http://purl.obolibrary.org/obo/GO_0051510 denotes cell growth regulation
T832 2545-2567 http://purl.obolibrary.org/obo/GO_0051510 denotes cell growth regulation
T833 2324-2346 http://purl.obolibrary.org/obo/GO_0051516 denotes cell growth regulation
T834 2545-2567 http://purl.obolibrary.org/obo/GO_0051516 denotes cell growth regulation
T853 3072-3107 http://purl.obolibrary.org/obo/GO_0045600 denotes cell activation and differentiation
T854 3231-3239 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T855 3231-3239 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T856 3493-3503 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T857 3231-3239 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T858 3231-3239 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T859 3339-3342 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T860 5135-5138 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T861 3349-3352 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T862 3353-3357 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T863 3349-3367 http://purl.obolibrary.org/obo/GO_0032872 denotes p38 MAPK signaling
T864 3349-3367 http://purl.obolibrary.org/obo/GO_0051403 denotes p38 MAPK signaling
T865 3353-3367 http://purl.obolibrary.org/obo/GO_0000165 denotes MAPK signaling
T866 3358-3376 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T867 6162-6180 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T868 6606-6624 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T869 3498-3503 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T870 3552-3591 http://purl.obolibrary.org/obo/GO_0043552 denotes activates phosphatidylinositol 3 kinase
T871 3593-3597 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T872 6136-6140 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T873 3871-3880 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T874 4130-4139 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T875 4590-4599 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T876 4201-4221 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T877 4247-4266 http://purl.obolibrary.org/obo/GO_0002377 denotes antibody production
T878 4355-4370 http://purl.obolibrary.org/obo/GO_0045190 denotes class switching
T879 6098-6108 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T3216 6735-6746 http://purl.obolibrary.org/obo/GO_0032502 denotes Development
T3217 7108-7119 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T3218 7343-7354 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T3219 8001-8012 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T3220 8367-8378 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T3221 7454-7465 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T4109 9104-9113 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T4110 9498-9507 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T4111 9124-9144 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T4112 10510-10530 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T4113 9526-9541 http://purl.obolibrary.org/obo/GO_0048469 denotes cell maturation
T4114 9733-9739 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T4115 9740-9752 http://purl.obolibrary.org/obo/GO_0002359 denotes B cells. B-1
T4116 9740-9752 http://purl.obolibrary.org/obo/GO_0001923 denotes B cells. B-1
T4117 10295-10299 http://purl.obolibrary.org/obo/GO_0007568 denotes aged
T4118 10355-10366 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T4119 12963-12974 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T5544 13712-13722 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T5545 14168-14171 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T5546 14335-14338 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T6403 17144-17157 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T6404 17211-17224 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T6405 17332-17345 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T6406 17902-17917 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6407 19625-19634 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T7573 19766-19772 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T7574 21055-21061 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T7575 21189-21195 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T7576 20222-20235 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T7577 21169-21195 http://purl.obolibrary.org/obo/GO_0045927 denotes upregulation on the growth
T7578 24337-24346 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T7579 24385-24396 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T9792 24451-24461 http://purl.obolibrary.org/obo/GO_0007049 denotes Cell Cycle
T9793 26827-26837 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T9794 27906-27916 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T9795 24535-24539 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T9796 24697-24706 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9797 27274-27283 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9798 25126-25141 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T9799 25446-25461 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T9800 27798-27813 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T9801 25693-25703 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T9802 27917-27927 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T9803 26666-26677 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T9804 27334-27345 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T9805 26741-26752 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T9806 27008-27019 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T9807 27028-27039 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T9808 27409-27420 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T9809 26793-26806 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T9810 27601-27614 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T9811 26827-26849 http://purl.obolibrary.org/obo/GO_0007050 denotes cell cycle progression
T9812 26827-26849 http://purl.obolibrary.org/obo/GO_0051726 denotes cell cycle progression
T9813 27838-27854 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T9814 27906-27935 http://purl.obolibrary.org/obo/GO_0051726 denotes cell cycle regulation through
T9815 27274-27291 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T9816 27906-27927 http://purl.obolibrary.org/obo/GO_0051445 denotes cell cycle regulation
T9817 27906-27927 http://purl.obolibrary.org/obo/GO_1901976 denotes cell cycle regulation
T9818 27906-27927 http://purl.obolibrary.org/obo/GO_0010564 denotes cell cycle regulation
T9819 27906-27927 http://purl.obolibrary.org/obo/GO_0032465 denotes cell cycle regulation
T9820 27906-27927 http://purl.obolibrary.org/obo/GO_0045787 denotes cell cycle regulation
T9821 27906-27927 http://purl.obolibrary.org/obo/GO_0007346 denotes cell cycle regulation
T9822 27906-27927 http://purl.obolibrary.org/obo/GO_0045786 denotes cell cycle regulation
T9823 27906-27927 http://purl.obolibrary.org/obo/GO_0071156 denotes cell cycle regulation
T11867 28591-28597 http://purl.obolibrary.org/obo/GO_0040007 denotes Growth
T11868 28720-28726 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11869 28915-28921 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11870 29388-29394 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11871 29486-29492 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11872 29634-29640 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11873 32224-32230 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11874 32737-32743 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11875 33179-33185 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11876 28894-28898 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T11877 33097-33101 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T11878 33230-33234 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T11879 33423-33427 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T11880 33093-33096 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T11881 33226-33229 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T11882 33419-33422 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T11883 29481-29492 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T11884 29873-29888 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T11885 31430-31439 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11886 31540-31549 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11887 33037-33046 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11888 31456-31466 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T11889 31965-31975 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T11890 32898-32908 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T11891 31461-31466 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T11892 31970-31975 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T11893 32903-32908 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T11894 33085-33088 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T11895 33179-33196 http://purl.obolibrary.org/obo/GO_0045926 denotes growth inhibition
T11896 33267-33271 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T14555 34438-34449 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T14556 35647-35658 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T14557 37417-37428 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T14558 37658-37669 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T14559 37786-37797 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T14560 42498-42509 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T14561 34981-34990 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14562 35231-35240 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14563 35625-35634 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14564 35781-35790 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14565 36095-36104 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14566 36365-36374 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14567 37887-37896 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14568 38470-38479 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14569 38559-38568 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14570 38718-38727 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14571 40657-40666 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14572 40755-40764 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14573 40848-40857 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14574 41862-41871 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14575 35195-35201 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T14576 35401-35410 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T14577 40591-40600 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T14578 40705-40714 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T14579 40812-40821 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T14580 40883-40892 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T14581 41241-41250 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T14582 35808-35832 http://purl.obolibrary.org/obo/GO_0001923 denotes B-1 cell differentiation
T14583 35812-35832 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T14584 36110-36130 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T14585 36890-36895 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T14586 36916-36919 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T14587 41781-41784 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T14588 37235-37259 http://purl.obolibrary.org/obo/GO_0001775 denotes cells and the activation
T14589 37309-37315 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T14590 38158-38164 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T14591 41975-41981 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T14592 42089-42095 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T14593 42186-42192 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T14594 38153-38164 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T14595 38470-38488 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T14596 38713-38717 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T14597 38833-38837 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T14598 39206-39210 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T14599 39361-39365 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T14600 40497-40501 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T14601 38713-38727 http://purl.obolibrary.org/obo/GO_0014065 denotes PI3K signaling
T14602 39304-39336 http://purl.obolibrary.org/obo/GO_1901988 denotes downregulation of the cell cycle
T14603 39304-39336 http://purl.obolibrary.org/obo/GO_1901994 denotes downregulation of the cell cycle
T14604 39304-39336 http://purl.obolibrary.org/obo/GO_1901977 denotes downregulation of the cell cycle
T14605 39304-39336 http://purl.obolibrary.org/obo/GO_1903451 denotes downregulation of the cell cycle
T14606 39326-39336 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T14607 41322-41332 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T14608 39450-39465 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T14609 39853-39868 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T14610 40410-40423 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T14611 40465-40478 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T14612 40553-40566 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T14613 41003-41011 http://purl.obolibrary.org/obo/GO_0085030 denotes mutually
T14614 41273-41283 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T14615 41322-41344 http://purl.obolibrary.org/obo/GO_0007050 denotes cell cycle progression
T14616 41322-41344 http://purl.obolibrary.org/obo/GO_0051726 denotes cell cycle progression
T18294 43117-43128 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T18616 43413-43419 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T19048 44654-44672 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T19049 45690-45705 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T19050 45690-45717 http://purl.obolibrary.org/obo/GO_0071888 denotes cell activation was induced
T19649 46535-46546 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T20343 47816-47829 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T21033 49404-49415 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T21812 8519-8530 http://purl.obolibrary.org/obo/GO_0032502 denotes Development
T21813 8976-8987 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T21814 8816-8827 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T23151 18573-18580 http://purl.obolibrary.org/obo/GO_0045292 denotes spliced
T24372 25775-25785 http://purl.obolibrary.org/obo/GO_0007049 denotes Cell Cycle
T24373 26217-26227 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T24374 25908-25917 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T24375 26176-26183 http://purl.obolibrary.org/obo/GO_0045292 denotes spliced
T24800 30253-30259 http://purl.obolibrary.org/obo/GO_0040007 denotes Growth
T24801 30523-30527 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T24802 30539-30542 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T24803 30764-30773 http://purl.obolibrary.org/obo/GO_0010309 denotes 2, and (E
T25242 30987-30993 http://purl.obolibrary.org/obo/GO_0040007 denotes Growth
T25243 31119-31128 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T835 2336-2346 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T836 2557-2567 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T837 2896-2905 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T838 3358-3367 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T839 3603-3612 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T840 3823-3832 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T841 6162-6171 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T842 6606-6615 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T843 3072-3087 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T844 3072-3107 http://purl.obolibrary.org/obo/GO_0014040 denotes cell activation and differentiation
T845 3072-3107 http://purl.obolibrary.org/obo/GO_0031287 denotes cell activation and differentiation
T846 3072-3107 http://purl.obolibrary.org/obo/GO_0045594 denotes cell activation and differentiation
T847 3072-3107 http://purl.obolibrary.org/obo/GO_0045606 denotes cell activation and differentiation
T848 3072-3107 http://purl.obolibrary.org/obo/GO_0045690 denotes cell activation and differentiation
T849 3072-3107 http://purl.obolibrary.org/obo/GO_1902107 denotes cell activation and differentiation
T850 3072-3107 http://purl.obolibrary.org/obo/GO_1902913 denotes cell activation and differentiation
T851 3072-3107 http://purl.obolibrary.org/obo/GO_0046534 denotes cell activation and differentiation
T852 3072-3107 http://purl.obolibrary.org/obo/GO_0045597 denotes cell activation and differentiation

GO-MF

Id Subject Object Predicate Lexical cue
T2659 3022-3028 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T2660 3152-3158 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T2661 3339-3342 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T2662 5135-5138 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T2663 3349-3352 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T2664 3353-3357 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T2665 3593-3597 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T2666 6136-6140 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T2667 4247-4255 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T2668 4335-4349 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T7023 19361-19369 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T7024 19405-19415 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T8919 22045-22055 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T8920 22300-22310 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T8921 22755-22763 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T8922 22819-22827 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T13576 28894-28898 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T13577 33097-33101 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T13578 33230-33234 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T13579 33423-33427 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T13580 33093-33096 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T11119 24535-24539 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T13581 33226-33229 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T13582 33419-33422 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T13583 33085-33088 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13584 33267-33271 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T17605 36621-36631 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T17606 40682-40692 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T17607 38713-38717 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T17608 38833-38837 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T17609 39206-39210 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T17610 39361-39365 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T17611 40497-40501 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T20009 46535-46546 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T20010 46716-46724 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T20308 46902-46910 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T20309 47374-47382 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T21369 49404-49415 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T21370 49899-49907 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T21371 49960-49970 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T23573 18701-18709 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T24182 23560-23568 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T25136 30523-30527 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T25137 30539-30542 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T25138 30764-30773 http://purl.obolibrary.org/obo/GO_0010309 denotes 2, and (E

GO-CC

Id Subject Object Predicate Lexical cue
T424 11-19 http://purl.obolibrary.org/obo/GO_0016020 denotes Membrane
T425 148-156 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T426 453-458 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T427 608-613 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T428 633-638 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T429 1007-1011 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2669 1993-1997 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2670 2324-2328 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2671 2545-2549 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2672 2616-2620 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2673 2963-2967 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2674 3072-3076 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2675 3435-3439 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2676 3493-3497 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2677 3964-3968 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2678 4201-4205 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2679 6098-6102 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5273 9124-9128 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5274 9526-9530 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5275 9854-9858 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5276 10510-10514 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5277 12473-12477 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5278 12790-12795 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5279 12944-12949 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6091 13254-13258 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6092 13839-13844 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6093 13946-13951 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6094 15303-15308 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6095 15518-15523 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6096 15626-15631 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6097 15752-15757 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6098 15967-15972 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6099 16206-16211 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6100 16325-16330 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7025 17201-17204 http://purl.obolibrary.org/obo/GO_0005662 denotes RPA
T7026 17291-17295 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7027 17390-17395 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7028 17484-17489 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7029 17798-17803 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7030 17873-17878 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7031 19143-19148 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7032 19483-19488 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7033 19557-19562 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7034 19361-19369 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T7035 19405-19415 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T7036 19361-19369 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T7037 19405-19415 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T8924 20331-20336 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8925 20537-20542 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8926 20828-20833 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8927 20985-20990 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8928 21223-21228 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8929 21358-21363 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8930 22104-22109 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8931 22357-22362 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8932 22536-22541 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8933 22626-22631 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8934 19888-19891 http://purl.obolibrary.org/obo/GO_0005662 denotes RPA
T8935 22045-22055 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T8936 22300-22310 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T8937 22755-22763 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T8938 22819-22827 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T8939 22045-22055 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T8940 22300-22310 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T8941 22755-22763 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T8942 22819-22827 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T8943 22846-22850 http://purl.obolibrary.org/obo/GO_0071735 denotes IgG1
T11122 24842-24847 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11123 24867-24872 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11124 25015-25020 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11125 25402-25407 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11126 26547-26552 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11127 26926-26931 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11128 27442-27447 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11129 27956-27961 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11130 28054-28059 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11131 28079-28084 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11132 28291-28296 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11133 28510-28515 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11134 24608-24611 http://purl.obolibrary.org/obo/GO_0005643 denotes NPC
T13585 29412-29417 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13586 29685-29690 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13587 30184-30189 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13588 31636-31641 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13589 31683-31688 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13590 32020-32025 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13591 32335-32340 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13592 32953-32958 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13593 33531-33536 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13594 33990-33995 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13595 34105-34110 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17612 34202-34206 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17613 34919-34923 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17614 35589-35593 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17615 35767-35771 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17616 35812-35816 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17617 36110-36114 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17618 36666-36670 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17619 36980-36984 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17620 38121-38125 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17621 38153-38157 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17622 38263-38267 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17623 39076-39080 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17624 39326-39330 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17625 41322-41326 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17626 41464-41469 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17627 41716-41721 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17628 36617-36631 http://purl.obolibrary.org/obo/GO_0071746 denotes IgA antibodies
T17629 36621-36631 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T17630 40682-40692 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T17631 36621-36631 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T17632 40682-40692 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T20310 46902-46910 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T20311 47374-47382 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T20312 46902-46910 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T20313 47374-47382 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T20314 46954-46957 http://purl.obolibrary.org/obo/GO_0005680 denotes APC
T20315 47113-47118 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20316 47180-47185 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20317 47301-47306 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20744 47617-47622 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20745 48199-48202 http://purl.obolibrary.org/obo/GO_0005662 denotes RPA
T22555 10712-10716 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T22556 10730-10734 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T23574 18098-18103 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23575 18375-18380 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23576 18661-18666 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23577 18701-18709 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T23578 18701-18709 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T2680 6525-6530 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2681 2092-2095 http://purl.obolibrary.org/obo/GO_0005643 denotes NPC
T2682 2809-2812 http://purl.obolibrary.org/obo/GO_0005643 denotes NPC
T2683 2501-2509 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T2684 2648-2656 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T2685 4006-4014 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T2686 4247-4255 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T2687 4247-4255 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T8923 19872-19877 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3815 6808-6813 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3816 6979-6984 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3817 7123-7128 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3818 7247-7252 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3819 7327-7332 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3820 7770-7775 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3821 7964-7969 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6090 13119-13123 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3822 8275-8280 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3823 7758-7775 http://purl.obolibrary.org/obo/GO_0005886 denotes membrane of cells
T3824 7751-7775 http://purl.obolibrary.org/obo/GO_0031520 denotes plasma membrane of cells
T3825 7751-7775 http://purl.obolibrary.org/obo/GO_0020002 denotes plasma membrane of cells
T3826 7758-7766 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T11120 24451-24455 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T11121 24646-24651 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19601 44556-44560 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T22557 11429-11434 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23041 14949-14954 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23042 15104-15109 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23043 15236-15241 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18992 43425-43430 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18993 43701-43706 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18994 44002-44007 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18995 44137-44142 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18996 44258-44262 http://purl.obolibrary.org/obo/GO_0071735 denotes IgG1
T18997 44287-44291 http://purl.obolibrary.org/obo/GO_0071735 denotes IgG1
T19602 44654-44658 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19603 45690-45694 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19604 45160-45164 http://purl.obolibrary.org/obo/GO_0071735 denotes IgG1
T19605 45188-45192 http://purl.obolibrary.org/obo/GO_0071735 denotes IgG1
T20011 46716-46724 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T20012 46716-46724 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T20013 46734-46738 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T21372 49147-49151 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T21373 49780-49789 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T21374 49841-49850 http://purl.obolibrary.org/obo/GO_0016020 denotes Membranes
T21375 49899-49907 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T21376 49960-49970 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T21377 49899-49907 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T21378 49960-49970 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T21691 50372-50375 http://purl.obolibrary.org/obo/GO_0005680 denotes APC
T21692 50497-50502 http://purl.obolibrary.org/obo/GO_0071735 denotes IgG2a
T21693 50930-50934 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T22037 8604-8609 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24183 23039-23044 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24184 23422-23427 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24185 23560-23568 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T24186 23560-23568 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T24187 23587-23591 http://purl.obolibrary.org/obo/GO_0071735 denotes IgG1
T24657 25775-25779 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T24658 25838-25843 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24659 26217-26221 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

sentences

Id Subject Object Predicate Lexical cue
T59 0-80 Sentence denotes EBV Latent Membrane Protein 1 Activates Akt, NFκB, and Stat3 in B Cell Lymphomas
T60 141-227 Sentence denotes Latent membrane protein 1 (LMP1) is the major oncoprotein of Epstein-Barr virus (EBV).
T61 228-309 Sentence denotes In transgenic mice, LMP1 promotes increased lymphoma development by 12 mo of age.
T62 310-439 Sentence denotes This study reveals that lymphoma develops in B-1a lymphocytes, a population that is associated with transformation in older mice.
T63 440-623 Sentence denotes The lymphoma cells have deregulated cell cycle markers, and inhibitors of Akt, NFκB, and Stat3 block the enhanced viability of LMP1 transgenic lymphocytes and lymphoma cells in vitro.
T64 624-760 Sentence denotes Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling.
T65 761-881 Sentence denotes These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition.
T66 882-1022 Sentence denotes These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.
T780 1750-1923 Sentence denotes Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus that infects humans predominantly at an early age with greater than 90% of the adult population infected with EBV [1].
T781 1924-2210 Sentence denotes EBV is linked to the development of both B lymphocyte and epithelial cell malignancies, including Burkitt lymphoma, Hodgkin disease (HD), and nasopharyngeal carcinoma (NPC), and cancers linked to immunosuppression, including post-transplant lymphoma and AIDS-associated lymphomas [2,3].
T782 2211-2395 Sentence denotes In vitro infection of B lymphocytes with EBV induces permanent growth transformation, and this ability to affect cell growth regulation likely contributes to the development of cancer.
T783 2396-2640 Sentence denotes Many of the viral proteins expressed in transformed cells, including the EBV nuclear antigens and latent membrane proteins, have profound effects on cell growth regulation and are required for EBV latent infection and B cell transformation [1].
T784 2641-2860 Sentence denotes Latent membrane protein 1 (LMP1) is considered the major oncoprotein of EBV, as it transforms rodent fibroblasts to tumorigenicity in nude mice and is expressed in HD, NPC, and immunosuppression-associated tumors [4–8].
T785 2861-2990 Sentence denotes In B lymphocytes, LMP1 mimics CD40 signaling, and both LMP1 and CD40 are essential for EBV-mediated B cell transformation [9–11].
T786 2991-3187 Sentence denotes While CD40 interacts with CD40 ligand expressed on activated T cells to induce B cell activation and differentiation, LMP1 acts as a constitutive signal through ligand-independent oligomerization.
T787 3188-3385 Sentence denotes LMP1 and CD40 interact with the same tumor necrosis factor receptor–associated factors (TRAFs) leading to activation of NFκB, c-Jun N terminal kinase (JNK), and p38 MAPK signaling pathways [12–16].
T788 3386-3512 Sentence denotes Activation of NFκB is required for EBV-induced B cell transformation and its inhibition rapidly results in cell death [17,18].
T789 3513-3712 Sentence denotes Recent studies indicate that LMP1 also activates phosphatidylinositol 3 kinase (PI3K)/Akt signaling and that this activation is required for LMP1-mediated transformation of rodent fibroblasts [5,19].
T790 3713-3808 Sentence denotes In vitro, primary B cells can be maintained by CD40 ligation in combination with IL4 treatment.
T791 3809-3996 Sentence denotes In vivo, CD40 signaling is necessary for germinal center (GC) formation such that mice deficient for CD40 or CD40L are unable to form GCs in response to T cell–dependent antigens [20,21].
T792 3997-4272 Sentence denotes Both the membrane proximal and distal cytoplasmic regions of CD40 that bind TRAF6 and TRAFs2/3/5, respectively, are necessary for GC formation, but either region is sufficient to induce extrafollicular B cell differentiation and restore low affinity antibody production [22].
T793 4273-4527 Sentence denotes Functionally, LMP1 can rescue CD40-deficient mice and restore immunoglobulin (Ig) class switching, most likely because LMP1 recruits similar TRAF molecules, TRAFs 1/2/3/5 and TRAF6, through the C-terminal activation regions 1 and 2 domains, respectively.
T794 4528-4605 Sentence denotes However, LMP1 is unable to restore affinity maturation and GC formation [23].
T795 4606-4816 Sentence denotes Several EBV transforming proteins have been studied in transgenic mouse models, however, only LMP1 induces tumor development when expressed under the control of the Ig heavy chain promoter and enhancer [24–26].
T796 4817-5066 Sentence denotes The LMP1 transgenic mice (IgLMP1) express LMP1 in B lymphocytes, and in mice older than 12 mo, lymphoma develops with increased incidence (40%–50%) compared to wild-type control mice (11%), suggesting that LMP1 contributes to tumor development [26].
T797 5067-5216 Sentence denotes The LMP1 lymphomas have rearranged Ig genes and have activated Akt, JNK, p38, and NFκB, with specific activation of the NFκB family member cRel [27].
T798 5217-5358 Sentence denotes In this study, the LMP1 transgenic lymphocytes and lymphomas were further characterized and their growth properties in vitro were determined.
T799 5359-5533 Sentence denotes To obtain pure populations of malignant lymphocytes and to enable more detailed biochemical analyses, examples of primary lymphomas were inoculated and passaged in SCID mice.
T800 5534-5683 Sentence denotes Interestingly, lymphoma development was restricted to B-1a lymphocytes, a self-replenishing population of cells that are prone to malignancy [28,29].
T801 5684-5796 Sentence denotes LMP1 transgenic lymphocytes had increased viability in vitro and viability was increased by the addition of IL4.
T802 5797-5996 Sentence denotes In contrast, both LMP1-positive and -negative lymphoma cells were independent of IL4 co-stimulation for survival and proliferation in vitro with a complete absence of activated Stat6, the IL4 target.
T803 5997-6117 Sentence denotes The lymphomas were also distinguished by constitutive activation of Stat3 and deregulation of the Rb cell cycle pathway.
T804 6118-6334 Sentence denotes Inhibition of the PI3K/Akt, NFκB, and Stat3 signaling pathways blocked the enhanced growth of both LMP1 transgenic and malignant lymphocytes, suggesting that these pathways are required for their growth and survival.
T805 6335-6472 Sentence denotes These appear to be the same targets that are deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition.
T806 6473-6673 Sentence denotes This study reveals that LMP1 promotes malignancy in cells with the inherent ability to proliferate and that the Akt, NFκB, and Stat3 signaling pathways are required for its growth stimulatory effects.
T3205 6684-6758 Sentence denotes High Levels of LMP1 Expression Correlates with the Development of Lymphoma
T3206 6759-6876 Sentence denotes LMP1 expression in IgLMP1 mice was directed to B cells under the control of the Ig heavy chain promoter and enhancer.
T3207 6877-7044 Sentence denotes It has previously been shown that in these transgenic mice, LMP1 expression was restricted to B220+ B cells with lymphoma detected in greatly enlarged spleens [23,26].
T3208 7045-7285 Sentence denotes To investigate whether LMP1 expression contributes to lymphoma development, B cells were purified from splenocytes by positive selection using anti-CD19 MACS magnetic beads, and equivalent amounts of B cells were analyzed by immunoblotting.
T3209 7286-7487 Sentence denotes LMP1 was detectable in LMP1 transgenic B cells, but upon development of lymphoma, LMP1 expression was stronger in 5/7 lymphomas analyzed with concomitant appearance of degradation products (Figure 1A).
T3210 7488-7680 Sentence denotes To determine whether the higher level of LMP1 detected was due to an expansion of malignant lymphocytes, expression of LMP1 in the spleen was further evaluated by immunohistochemical staining.
T3211 7681-7866 Sentence denotes Immunohistochemistry analysis of spleen sections detected LMP1 in the plasma membrane of cells in both the follicular white pulp and circulating lymphocytes in the red pulp (Figure 1B).
T3212 7867-7995 Sentence denotes LMP1 expression was heterogeneous with strong LMP1 staining interspersed amongst a background of cells staining weakly for LMP1.
T3213 7996-8115 Sentence denotes Upon development to lymphoma, LMP1 expression was more abundantly detected with multiple foci of intense LMP1 staining.
T3214 8116-8312 Sentence denotes This demonstrates that the increased LMP1 detected by immunoblotting upon malignant progression reflects an increase in LMP1 expression and an accumulation of cells expressing high levels of LMP1.
T3215 8313-8467 Sentence denotes This correlation between high LMP1 expression and the development of lymphoma suggests that progression to lymphoma results from increased levels of LMP1.
T4090 9020-9082 Sentence denotes LMP1 Promotes B-1a Lymphomas That Can Escape Allelic Exclusion
T4091 9083-9325 Sentence denotes To determine if LMP1 signaling affects B cell differentiation and to immunophenotype the lymphomas that arise from LMP1 expression, surface Ig expression of heavy chains (IgM, IgG, IgD) and light chains (κ, λ) were analyzed by flow cytometry.
T4092 9326-9561 Sentence denotes Similar numbers of naïve (IgM+IgD+IgG−) splenic B cells with a strong bias towards κ light chain were detected from wild-type or LMP1 transgenic mice, indicating that LMP1 signaling does not affect B cell maturation (unpublished data).
T4093 9562-9748 Sentence denotes Flow cytometry analysis of the SCID-passaged wild-type and LMP1 transgenic lymphomas revealed an IgMhighIgDlow phenotype (Figure 2A), indicative of marginal zone, B-1, or memory B cells.
T4094 9749-9822 Sentence denotes B-1 cells are further separated into CD5+ (B-1a) and CD5− (B-1b) subsets.
T4095 9823-9927 Sentence denotes To differentiate between these cell types, lymphoma cells were further analyzed for the B-1a marker CD5.
T4096 9928-10084 Sentence denotes All (5/5) of the tested LMP1 transgenic lymphomas displayed an IgMhighIgDlowCD5+ phenotype (Figure 2A), an expression pattern that distinguishes B-1a cells.
T4097 10085-10174 Sentence denotes Interestingly, a spontaneous wild-type lymphoma also developed in B-1a cells (Figure 2A).
T4098 10175-10310 Sentence denotes These cells are an interesting population that is self replenishing with an increased likelihood to become malignant in aged mice [30].
T4099 10311-10543 Sentence denotes Analysis of LMP1 transgenic mice before the development of lymphoma showed similar numbers of splenic B-1a (CD19+CD5+) and B-1b or B-2 populations (CD19+CD5−), indicating that LMP1 does not affect B cell differentiation (Figure 2B).
T4100 11525-11703 Sentence denotes Due to allelic exclusion, mature B cells that have been exposed to antigen will typically express only one heavy chain isotype (IgG, IgE, or IgA) and either a κ or λ light chain.
T4101 11704-11855 Sentence denotes Interestingly, 2/5 LMP1 transgenic lymphomas analyzed (lymphomas 2 and 4) were doubly positive for low levels of both κ and λ light chains (Figure 2A).
T4102 11856-12108 Sentence denotes Previous characterization of the LMP1 lymphomas had revealed that the lymphomas were clonal as determined by Ig heavy chain rearrangement [26], and analysis of κ chain rearrangement (Figure S1) of the samples analyzed in this study confirmed clonality.
T4103 12109-12239 Sentence denotes To further assess light chain expression, the passaged samples were tested by immunoblotting for κ and λ light chains (Figure 2C).
T4104 12240-12338 Sentence denotes Interestingly, very low levels of expression of both light chains were detected by flow cytometry.
T4105 12339-12478 Sentence denotes The low levels of expression may reflect a limitation of the total number of light chains that can be expressed on the surface of a B cell.
T4106 12479-12698 Sentence denotes In agreement with the flow cytometry analysis, LMP1 transgenic lymphomas 2 and 4 were also positive for κ and λ light chains by immunoblot analysis (Figure 2C), confirming that these lymphomas express both light chains.
T4107 12699-12887 Sentence denotes A previous study of mice that developed leukemia due to an expansion of self-reactive B-1a cells determined that the B-1a leukemias were also doubly positive for κ and λ light chains [31].
T4108 12888-13050 Sentence denotes These findings indicate that expression of LMP1 in B-1a cells promotes the development of malignancy and can result in the aberrant escape from allelic exclusion.
T5525 13052-13108 Sentence denotes LMP1 Promotes B Cell Survival and Proliferation In Vitro
T5526 13109-13207 Sentence denotes Primary B cell cultures can be maintained through CD40 ligation and supplementation with IL4 [32].
T5527 13208-13514 Sentence denotes To investigate whether LMP1 affects primary B cell survival and proliferation, splenocytes were cultured in the presence or absence of IL4 and analyzed by MTS as a metabolic marker, by ethidium monoazide (EMA) exclusion for viability, and by 5-bromo-2′-deoxy-uridine (BrdU) incorporation for proliferation.
T5528 13515-13667 Sentence denotes In the MTS assay, as expected, splenocytes from wild-type mice did not survive even with the addition of IL4 due to a lack of CD40 ligation (Figure 3A).
T5529 13668-13799 Sentence denotes In contrast, LMP1 splenocytes had increased metabolism even in the absence of IL4, which was further enhanced upon addition of IL4.
T5530 13800-13916 Sentence denotes Wild-type and LMP1 transgenic lymphoma cells had high levels of MTS activity even in the absence of IL4 (Figure 3A).
T5531 13917-14094 Sentence denotes The LMP1 transgenic lymphoma cells had approximately 4-fold higher MTS activity than the normal transgenic lymphocytes and were at least 2-fold higher than the control lymphoma.
T5532 14095-14212 Sentence denotes As previously published, lymphoma usually develops in mice over 12 mo of age and all mice are sacrificed by 18–20 mo.
T5533 14213-14301 Sentence denotes The ages of the transgenic mice with or without lymphoma ranged between 6 and 20 mo old.
T5534 14302-14356 Sentence denotes There was no correlation between age and MTS activity.
T5535 15272-15476 Sentence denotes EMA exclusion of CD19+ gated B cells prepared from two wild-type and two LMP1 transgenic mice indicated a 2-fold increase in viability in the LMP1 transgenic lymphocytes compared to wild-type lymphocytes.
T5536 15477-15682 Sentence denotes Two examples of LMP1 transgenic lymphoma cells had greatly increased viability that was not increased by IL4 treatment, indicating that the lymphoma cells are independent of IL4 co-stimulation (Figure 3B).
T5537 15683-15839 Sentence denotes Enhancement in MTS activity was observed in LMP1 transgenic lymphoma cells by the addition of IL4; however, EMA exclusion did not reveal a similar increase.
T5538 15840-15973 Sentence denotes This could reflect a difference for IL4 requirement in the metabolic activity versus the viability of LMP1 transgenic lymphoma cells.
T5539 15974-16191 Sentence denotes Although expression of LMP1 could enhance survival of non-malignant primary lymphocytes, BrdU incorporation revealed that LMP1 expression alone was not sufficient to induce proliferation in culture (unpublished data).
T5540 16192-16295 Sentence denotes Only lymphoma cells had detectable levels of BrdU incorporation detected by flow cytometry (Figure 3C).
T5541 16296-16484 Sentence denotes Interestingly, LMP1 lymphoma cells had significantly higher levels of proliferation in comparison to the spontaneous lymphoma that developed in an LMP1-negative littermate (25% versus 4%).
T5542 16485-16744 Sentence denotes This higher level of proliferation was observed in lymphomas that express both high (Table 1, LMP1-L2 and LMP1-L3) and low (Table 1, LMP1-L5) levels of LMP1, suggesting that even small amounts of LMP1 is sufficient to induce dramatic effects in proliferation.
T5543 16745-16894 Sentence denotes The level of proliferation was not enhanced upon IL4 addition, confirming the IL4 independence observed in the viability studies (Figure 3C; Table1).
T6392 8678-17061 Sentence denotes wild-type (WT) and LMP1 transgenic mice. (A) Lymphomas are identified with a number (1–7). Arrows indicate the LMP1-specific band and its degradation products as well as a non-specific band. Actin was used as a loading control. (B) White and red pulps are shown, but this architecture is lost upon development of lymphoma. Scale bar, 20 μm. LMP1 Promotes B-1a Lymphomas That Can Escape Allelic Exclusion To determine if LMP1 signaling affects B cell differentiation and to immunophenotype the lymphomas that arise from LMP1 expression, surface Ig expression of heavy chains (IgM, IgG, IgD) and light chains (κ, λ) were analyzed by flow cytometry. Similar numbers of naïve (IgM+IgD+IgG−) splenic B cells with a strong bias towards κ light chain were detected from wild-type or LMP1 transgenic mice, indicating that LMP1 signaling does not affect B cell maturation (unpublished data). Flow cytometry analysis of the SCID-passaged wild-type and LMP1 transgenic lymphomas revealed an IgMhighIgDlow phenotype (Figure 2A), indicative of marginal zone, B-1, or memory B cells. B-1 cells are further separated into CD5+ (B-1a) and CD5− (B-1b) subsets. To differentiate between these cell types, lymphoma cells were further analyzed for the B-1a marker CD5. All (5/5) of the tested LMP1 transgenic lymphomas displayed an IgMhighIgDlowCD5+ phenotype (Figure 2A), an expression pattern that distinguishes B-1a cells. Interestingly, a spontaneous wild-type lymphoma also developed in B-1a cells (Figure 2A). These cells are an interesting population that is self replenishing with an increased likelihood to become malignant in aged mice [30]. Analysis of LMP1 transgenic mice before the development of lymphoma showed similar numbers of splenic B-1a (CD19+CD5+) and B-1b or B-2 populations (CD19+CD5−), indicating that LMP1 does not affect B cell differentiation (Figure 2B). Figure 2 LMP1 Promotes B-1a Lymphomas That Can Escape Allelic Exclusion (A) Flow cytometry analysis of splenocytes from a WT or LMP1 transgenic lymphoma for the pan–B cell (CD19), B-1a cell (CD5), and Ig heavy chain (IgM and IgD) and light chain (κ and λ) markers. Shown are the results from WT lymphoma 1 and LMP1 transgenic lymphoma 4. This analysis was repeated on four other LMP1 transgenic lymphomas (1, 2, 3, and 6) showing a similar B-1a phenotype, of which lymphomas 2 and 4 were also doubly positive for κ and λ light chains. (B) Flow cytometry analysis of WT or LMP1 transgenic splenocytes for B-1a (CD19+CD5+) and B-1b or B2 subsets (CD19+CD5−). Percentages of B-1a and B-1b or B2 subsets are shown in each quadrant. This analysis was repeated on three other WT and two other LMP1 transgenic mice with similar results. (C) Immunoblot analysis for κ and λ light chains of B cells (CD19+) purified from WT and LMP1 transgenic mice. Actin was used as a loading control. Due to allelic exclusion, mature B cells that have been exposed to antigen will typically express only one heavy chain isotype (IgG, IgE, or IgA) and either a κ or λ light chain. Interestingly, 2/5 LMP1 transgenic lymphomas analyzed (lymphomas 2 and 4) were doubly positive for low levels of both κ and λ light chains (Figure 2A). Previous characterization of the LMP1 lymphomas had revealed that the lymphomas were clonal as determined by Ig heavy chain rearrangement [26], and analysis of κ chain rearrangement (Figure S1) of the samples analyzed in this study confirmed clonality. To further assess light chain expression, the passaged samples were tested by immunoblotting for κ and λ light chains (Figure 2C). Interestingly, very low levels of expression of both light chains were detected by flow cytometry. The low levels of expression may reflect a limitation of the total number of light chains that can be expressed on the surface of a B cell. In agreement with the flow cytometry analysis, LMP1 transgenic lymphomas 2 and 4 were also positive for κ and λ light chains by immunoblot analysis (Figure 2C), confirming that these lymphomas express both light chains. A previous study of mice that developed leukemia due to an expansion of self-reactive B-1a cells determined that the B-1a leukemias were also doubly positive for κ and λ light chains [31]. These findings indicate that expression of LMP1 in B-1a cells promotes the development of malignancy and can result in the aberrant escape from allelic exclusion. LMP1 Promotes B Cell Survival and Proliferation In Vitro Primary B cell cultures can be maintained through CD40 ligation and supplementation with IL4 [32]. To investigate whether LMP1 affects primary B cell survival and proliferation, splenocytes were cultured in the presence or absence of IL4 and analyzed by MTS as a metabolic marker, by ethidium monoazide (EMA) exclusion for viability, and by 5-bromo-2′-deoxy-uridine (BrdU) incorporation for proliferation. In the MTS assay, as expected, splenocytes from wild-type mice did not survive even with the addition of IL4 due to a lack of CD40 ligation (Figure 3A). In contrast, LMP1 splenocytes had increased metabolism even in the absence of IL4, which was further enhanced upon addition of IL4. Wild-type and LMP1 transgenic lymphoma cells had high levels of MTS activity even in the absence of IL4 (Figure 3A). The LMP1 transgenic lymphoma cells had approximately 4-fold higher MTS activity than the normal transgenic lymphocytes and were at least 2-fold higher than the control lymphoma. As previously published, lymphoma usually develops in mice over 12 mo of age and all mice are sacrificed by 18–20 mo. The ages of the transgenic mice with or without lymphoma ranged between 6 and 20 mo old. There was no correlation between age and MTS activity. Figure 3 LMP1 Promotes B Cell Survival and Proliferation In Vitro (A) MTS assay of splenocytes from WT and LMP1 transgenic mice. Splenocytes were cultured in the presence (grey bars) or absence (black bars) of IL4 for 3 d. The results are the mean ± SEM of triplicate samples averaged from multiple mice where “n” the number of mice analyzed is as follows: n = 2 for WT lymphocytes and WT lymphomas, n = 11 for LMP1 transgenic lymphocytes, and n = 13 for LMP1 transgenic lymphomas. (B) EMA exclusion of CD19+ gated splenocytes from WT and LMP1 transgenic mice showing percentage of viable B cells cultured with (white bars) or without (black bars) IL4 for 2 d. (C) Flow cytometry analysis for incorporated BrdU in WT and LMP1 transgenic lymphoma cells cultured with or without IL4 for 2 d. Shown are the results from WT lymphoma 1 and LMP1 transgenic lymphoma 2. Percentages of cells in each quadrant are shown. EMA exclusion of CD19+ gated B cells prepared from two wild-type and two LMP1 transgenic mice indicated a 2-fold increase in viability in the LMP1 transgenic lymphocytes compared to wild-type lymphocytes. Two examples of LMP1 transgenic lymphoma cells had greatly increased viability that was not increased by IL4 treatment, indicating that the lymphoma cells are independent of IL4 co-stimulation (Figure 3B). Enhancement in MTS activity was observed in LMP1 transgenic lymphoma cells by the addition of IL4; however, EMA exclusion did not reveal a similar increase. This could reflect a difference for IL4 requirement in the metabolic activity versus the viability of LMP1 transgenic lymphoma cells. Although expression of LMP1 could enhance survival of non-malignant primary lymphocytes, BrdU incorporation revealed that LMP1 expression alone was not sufficient to induce proliferation in culture (unpublished data). Only lymphoma cells had detectable levels of BrdU incorporation detected by flow cytometry (Figure 3C). Interestingly, LMP1 lymphoma cells had significantly higher levels of proliferation in comparison to the spontaneous lymphoma that developed in an LMP1-negative littermate (25% versus 4%). This higher level of proliferation was observed in lymphomas that express both high (Table 1, LMP1-L2 and LMP1-L3) and low (Table 1, LMP1-L5) levels of LMP1, suggesting that even small amounts of LMP1 is sufficient to induce dramatic effects in proliferation. The level of proliferation was not enhanced upon IL4 addition, confirming the IL4 independence observed in the viability studies (Figure 3C; Table1). Table 1 Summary of Analysis Performed on Wild-Type and LMP1 Transgenic Lymphomas Wild-Type and LMP1 Transgenic Lymphoma Cells Do Not Require IL4 and Stat6 Signaling
T6393 17062-17206 Sentence denotes To investigate whether IL4 independence was due to endogenous IL4 expression, IL4 transcription was assessed by an Rnase protection assay (RPA).
T6394 17207-17318 Sentence denotes IL4 transcription was detectable with control RNA and faintly in the mouse lymphoma cell line K46μ (Figure 4A).
T6395 17319-17566 Sentence denotes However, IL4 transcription was not detectable in CD19+ MACS-purified B cells from wild-type lymphocytes (unpublished data), LMP1 transgenic lymphocytes, or lymphoma cells, although the GAPDH and L32 controls were effectively protected (Figure 4A).
T6396 17567-17705 Sentence denotes Activated Stat6 (pStat6), a target of the IL4 receptor pathway, was detected in the wild-type and LMP1 transgenic lymphocytes (Figure 4B).
T6397 17706-17804 Sentence denotes In contrast, pStat6 was barely detected in either the wild-type or LMP1 transgenic lymphoma cells.
T6398 17805-17930 Sentence denotes However, the pathway was not disabled, as treatment of the lymphoma cells with IL4 induced Stat6 phosphorylation (Figure 4C).
T6399 18976-19244 Sentence denotes Although wild-type lymphocytes cannot be maintained in culture with IL4 supplementation alone (Figure 3A), slight enhancement in MTS activity could be detected if the cells were analyzed at an earlier time point, at 1 d (Figure 4D) versus 3 d (Figure 3A) post-harvest.
T6400 19245-19382 Sentence denotes The enhancement of MTS activity induced by IL4 in wild-type lymphocytes could be neutralized by the addition of IL4 antibody (Figure 4D).
T6401 19383-19501 Sentence denotes However, neutralizing antibodies to IL4 did not affect the MTS activity of LMP1 transgenic lymphoma cells (Figure 4E).
T6402 19502-19635 Sentence denotes In summary, the wild-type and LMP1 transgenic lymphoma cells grew independently of IL4 treatment and did not require Stat6 signaling.
T7551 19637-19693 Sentence denotes LMP1 Upregulates IL10 and Constitutively Activates Stat3
T7552 19694-19958 Sentence denotes To identify cytokines that may contribute to the increased survival and growth of lymphomas, the expression levels of a panel of cytokines were screened on CD19+ MACS-purified B cells, using an RPA probe set for IL4, IL5, IL10, IL13, IL15, IL9, IL2, IL6, and IFNγ.
T7553 19959-20069 Sentence denotes Expression levels were quantified with a phosphorimager and normalized to the ribosomal housekeeping gene L32.
T7554 20070-20221 Sentence denotes None of the tested cytokines were detected in wild-type lymphocytes, therefore cytokine:L32 ratios were set to 1 in the mouse B cell lymphoma line 967.
T7555 20222-20416 Sentence denotes Transcription of IL10, IL15, and IFNγ were reproducibly detected in LMP1 transgenic lymphocytes and lymphoma cells and was higher than in the B cell lymphoma cell lines 967 and K46μ (Figure 5A).
T7556 20417-20697 Sentence denotes There was no significant difference in the expression of IL15 and IFNγ between LMP1 transgenic lymphocytes and lymphoma cells, suggesting that upregulation of IL15 and IFNγ is induced by LMP1 expression in healthy lymphocytes but is not a unique property of malignant lymphocytes.
T7557 20698-20886 Sentence denotes Strikingly, IL10, a B lymphocyte stimulatory cytokine, was increased 1.5- to 5-fold in the wild-type and LMP1 transgenic lymphoma cells compared to LMP1 transgenic lymphocytes (Figure 5A).
T7558 20887-21026 Sentence denotes Production of IL15 and IFNγ has been associated with induction of cytotoxic effector responses in cells latently infected with EBV [33,34].
T7559 21027-21251 Sentence denotes However, transformation and growth properties induced by EBV are associated with the upregulation of IL10 [35–38]; hence, the effects of IL10 upregulation on the growth properties of the lymphoma cells were further examined.
T7560 21252-21496 Sentence denotes Immunoblot analysis indicated that LMP1 transgenic lymphocytes and wild-type and LMP1 transgenic lymphoma cells had corresponding increased levels of phosphorylated α and β isoforms of activated Stat3, a target of the IL10 receptor (Figure 5B).
T7561 21497-21638 Sentence denotes However, when comparing the same lymphomas, there was no correlation between the levels of IL10 induction and the levels of Stat3 activation.
T7562 21639-21757 Sentence denotes This suggests that the activation of Stat3 is not solely induced by IL10 or that Stat3 activation may be constitutive.
T7563 21758-21888 Sentence denotes Additionally, there was no correlation between the levels of LMP1 expression and the levels of IL10 induction (Figures 1A and 5A).
T7564 21889-22031 Sentence denotes This indicates that the induction of IL10 is a general property associated with enhanced survival and may only be indirectly affected by LMP1.
T7565 22032-22205 Sentence denotes Neutralizing antibodies to IL10 did not affect the survival of lymphoma cells as determined by the MTS assay (unpublished data), suggesting constitutive activation of Stat3.
T7566 22206-22429 Sentence denotes This was confirmed by immunoblot analysis such that in the presence of anti-IL10 neutralizing antibodies, pStat3 levels remained activated in lymphoma cells isolated from wild-type and LMP1 transgenic lymphomas (Figure 5C).
T7567 22430-22587 Sentence denotes Exogenous addition of IL10 enhanced pStat3 activation above constitutive levels, indicating that lymphoma cells are responsive to IL10 treatment (Figure 5C).
T7568 22588-22713 Sentence denotes This means that although the lymphoma cells have constitutive Stat3 activation, it may be further enhanced by IL10 induction.
T7569 22714-22879 Sentence denotes The neutralizing effect of the anti-IL10 antibody was confirmed by pre-incubation of IL10 with anti-IL10 antibody compared to a rat IgG1 isotype control (Figure 5C).
T7570 23916-24086 Sentence denotes Nuclear translocation of pStat3 is a consequence of activation, and nuclear pStat3 was not detected by immunohistochemistry staining of spleen sections from control mice.
T7571 24087-24251 Sentence denotes However, nuclear pStat3 was detectable in LMP1 transgenic mice and wild-type lymphomas and was detected more homogeneously in LMP1 transgenic lymphomas (Figure 5D).
T7572 24252-24397 Sentence denotes The constitutive activation of pStat3 and abundant nuclear Stat3 suggests that Stat3 signaling contributes to LMP1-mediated lymphoma development.
T9769 24399-24469 Sentence denotes LMP1 Activates Akt Signaling and Deregulates the Rb Cell Cycle Pathway
T9770 24470-24552 Sentence denotes LMP1 transformation of rodent fibroblasts requires activation of PI3K and Akt [5].
T9771 24553-24676 Sentence denotes Additionally, activated pAkt is frequently detected in NPC and the neoplastic Reed-Sternberg cells of classical HD [39,40].
T9772 24677-24848 Sentence denotes To determine if Akt signaling is activated in LMP1 transgenic mice, pAkt and several of its targets were assessed by immunoblotting of splenic CD19+ MACS-purified B cells.
T9773 24849-25058 Sentence denotes LMP1 transgenic B cells had increased levels of pAkt compared to wild-type lymphocytes; however, progression to lymphoma in both LMP1-positive and -negative lymphoma cells did not further increase pAkt levels.
T9774 25059-25287 Sentence denotes The Akt target glycogen synthase kinase 3 (GSK3) is inactivated by phosphorylation; however, increased phosphorylated GSK3 was not detected in the transgenic lymphocytes and was almost absent in the lymphoma samples (Figure 6A).
T9775 25288-25408 Sentence denotes This finding indicates that GSK3 is not a target of activated Akt in the LMP1 transgenic lymphocytes and lymphoma cells.
T9776 25409-25520 Sentence denotes Similarly, activation of Akt without phosphorylation of GSK3 has been previously shown in EBV-positive HD [40].
T9777 25521-25625 Sentence denotes In contrast, the wild-type lymphocytes lacked activated Akt but did have detectable phosphorylated GSK3.
T9778 25626-25712 Sentence denotes This further suggests that additional pathways are involved in the regulation of GSK3.
T9779 26382-26468 Sentence denotes To identify other potential Akt targets, immunoblot analysis for p-mTOR was performed.
T9780 26469-26690 Sentence denotes Activated p-mTOR was not increased in LMP1 transgenic lymphocytes or lymphoma cells, indicating that this pathway is not affected by LMP1-induced Akt activation and does not contribute to lymphoma development (Figure 6B).
T9781 26691-26892 Sentence denotes Akt is also known to phosphorylate and induce the degradation of the pro-apoptotic Forkhead family of transcription factors, leading to cell cycle progression and survival in some human tumors [41,42].
T9782 26893-27020 Sentence denotes Immunoblot analysis of splenic B cells did not consistently detect p-FoxO1 levels, a signal that targets FoxO1 for degradation.
T9783 27021-27097 Sentence denotes Hence, degradation of FoxO1 was assessed by detection of total FoxO1 levels.
T9784 27098-27346 Sentence denotes Immunoblot analysis indicated that total FoxO1 levels were greatly decreased in wild-type and LMP1 transgenic lymphomas (Figure 6B), suggesting that inhibition of the Forkhead signaling pathway is an important target of Akt in lymphoma development.
T9785 27347-27577 Sentence denotes However, considering that Akt activation did not induce FoxO1 degradation in LMP1 transgenic B cells, Akt may not be the sole regulator of FoxO1, and it may be that progression to lymphoma requires modulation of multiple pathways.
T9786 27578-27690 Sentence denotes The Forkhead family of transcription factors is known to induce the expression of the Cdk inhibitor p27 [43,44].
T9787 27691-27868 Sentence denotes LMP1-transformed rodent fibroblasts have decreased expression of p27, upregulation of Cdk2, and subsequent phosphorylation and inactivation of the tumor suppressor gene Rb [45].
T9788 27869-28060 Sentence denotes To investigate whether LMP1 affected cell cycle regulation through the Rb pathway in B cells, immunoblot analyses for pRb, Cdk2, and p27 were performed on splenic CD19+ MACS-purified B cells.
T9789 28061-28219 Sentence denotes LMP1 transgenic B cells had enhanced levels of pRb with concomitant stabilization of total Rb levels and Cdk2 compared to wild-type B lymphocytes (Figure 6C).
T9790 28220-28405 Sentence denotes Progression to lymphoma in both wild-type and LMP1 transgenic lymphoma cells led to increased levels of Rb, correspondingly high levels of Cdk2, and decreased levels of p27 (Figure 6C).
T9791 28406-28569 Sentence denotes These data indicate that the Rb pathway is deregulated in LMP1 transgenic lymphocytes and that lymphoma cells are distinguished by loss of FoxO1 and decreased p27.
T11843 28571-28662 Sentence denotes LMP1 Promotes Tumor Growth and Survival through Activation of Akt, NFκB, and Stat3 Pathways
T11844 28663-28952 Sentence denotes To explore which pathways were required for the enhanced growth and survival of LMP1-induced lymphomas, splenocytes from wild-type and LMP1 transgenic mice were cultured in the presence of inhibitors for Akt, NFκB, Stat3, mTOR, or MAPK and assayed for growth and survival by the MTS assay.
T11845 28953-29067 Sentence denotes As previously shown, wild-type lymphocytes were not viable in culture and could not be tested with the inhibitors.
T11846 29068-29306 Sentence denotes However, the enhanced viability of LMP1 transgenic lymphocytes was effectively blocked by treatment with triciribine, BAY11–7085, cucurbitacin I, and slightly with SB203580, but not by treatment with rapamycin, U0126, or AG490 (Figure 7).
T11847 29307-29450 Sentence denotes Triciribine inhibits the activation of Akt and at 20 μM has been shown to induce growth arrest in cancer cells with aberrant Akt activity [46].
T11848 29451-29702 Sentence denotes The effects of triciribine on cell growth of the transgenic lymphocytes and lymphomas were apparent as low as 1 μM, suggesting that activation of Akt is required for the survival and growth of LMP1 transgenic lymphocytes and lymphoma cells (Figure 7).
T11849 29703-29825 Sentence denotes The effects of the inhibitors were assessed by identifying phosphorylated Akt, Stat3, and total levels of IκBα (Figure 8).
T11850 29826-29953 Sentence denotes Treatment with triciribine effectively blocked phosphorylation of Akt, and phosphorylated Akt was no longer detected past 5 μM.
T11851 29954-30012 Sentence denotes Phosphorylated Stat3 and IκBα were still present at 25 μM.
T11852 30013-30190 Sentence denotes These findings suggest that triciribine specifically targets Akt and that Akt activation is required for the enhanced viability of the transgenic lymphocytes and lymphoma cells.
T11853 31411-31506 Sentence denotes Inhibition of NFκB signaling rapidly induces cell death of EBV-transformed lymphocytes [17,18].
T11854 31507-31726 Sentence denotes BAY11–7085, an inhibitor of NFκB signaling, also greatly decreased the viability of the LMP1 transgenic lymphocytes and lymphoma cells at doses as low as 1 μM, and at 5 μM the cells were completely nonviable (Figure 7).
T11855 31727-31774 Sentence denotes This is well within the reported IC50 of 10 μM.
T11856 31775-31907 Sentence denotes Phosphorylated Akt, Stat3, and total IκBα were still present up to treatment with 15 μM and then were no longer detected (Figure 8).
T11857 31908-32084 Sentence denotes This finding suggests that inhibition of NFκB can induce cell death in LMP1 transgenic lymphocytes and lymphoma cells without significant effects on activation of Akt or Stat3.
T11858 32085-32178 Sentence denotes Cucurbitacin I inhibits activation of Stat3 by suppressing the activation of its kinase JAK2.
T11859 32179-32282 Sentence denotes It has been shown to selectively inhibit the growth of tumors with constitutively activated Stat3 [47].
T11860 32283-32485 Sentence denotes Similarly, LMP1 transgenic lymphocytes and lymphoma cells were susceptible to cucurbitacin I treatment starting at 0.1 μM, a dose that corresponds closely to the reported IC50 of 500 nM (Figure 7) [47].
T11861 32486-32674 Sentence denotes Phosphorylated Akt, Stat3, and total IκBα were not detectable past 1 μM and at higher doses all protein levels were greatly decreased, indicative of the total loss of viability (Figure 8).
T11862 32675-32838 Sentence denotes A second reported inhibitor of Stat3, AG490, had no effect on growth (Figure 7), but activation of Akt, Stat3, or levels of IκBα were also not affected (Figure 8).
T11863 32839-33047 Sentence denotes These findings suggest that inhibition of Stat3 can induce cell death in LMP1 transgenic lymphocytes and lymphoma cells, but Stat3 inhibition also has considerable crossover effects on Akt and NFκB signaling.
T11864 33048-33283 Sentence denotes LMP1 has also been shown to activate JNK and p38 MAPK pathways [13,48], and LMP1 transgenic lymphocytes were mildly susceptible to growth inhibition by SB202190, an inhibitor of p38 MAPK, but not U0126, an inhibitor of MEK1/2 activity.
T11865 33284-33548 Sentence denotes However, effects of SB202190 were only apparent at high doses (>10 μM), much higher than the reported IC50 of 0.35 μM, suggesting that p38 MAPK does not significantly contribute to the enhanced viability in LMP1 transgenic lymphocytes or lymphoma cells (Figure 7).
T11866 33549-34122 Sentence denotes Interestingly, both wild-type and LMP1 transgenic lymphomas were similarly susceptible to triciribine, BAY11–7085, and cucurbitacin I treatments, but not SB202190, AG490, or U0126 treatment, suggesting that activation of Akt, NFκB, and Stat3 but not MAPK pathways are characteristics associated with malignant transformation (Figure 7). rapamycin, an inhibitor of mTOR, did not affect the viability of the transgenic lymphocytes or lymphoma cells, confirming that mTOR is not targeted by Akt activation in LMP1 transgenic lymphocytes or malignant lymphoma cells (Figure 7).
T14516 36572-36722 Sentence denotes B-1 cells produce the main source of IgM and IgA antibodies in serum, which are involved in T cell–independent responses to common microbial antigens.
T14517 36723-36840 Sentence denotes Importantly, B-1 cells have the unique capacity to self replenish and are also predisposed to transformation [28,29].
T14518 36841-37019 Sentence denotes Clonal expansion of B-1 cells can be detected in aging mice above 18 mo of age, and B-1 cells are thought to be the murine progenitor of B cell chronic lymphocytic leukemia [30].
T14519 37020-37194 Sentence denotes The data presented in this study indicate that although LMP1 is expressed in all B lymphocytes in the transgenic mice, malignancy develops in this specific subset of B cells.
T14520 37195-37316 Sentence denotes The elevated expression of LMP1 in B-1a cells and the activation of specific pathways apparently induce malignant growth.
T14521 37317-37429 Sentence denotes These same pathways can also become sporadically activated in aged mice and also result in lymphoma development.
T14522 37430-37609 Sentence denotes This is similar to EBV-associated cancers in vivo, where pathways that are activated by LMP1 are also activated in the less prevalent EBV-negative forms of the cancers [40,55–58].
T14523 37610-37798 Sentence denotes Thus, the contribution of EBV and LMP1 to tumor development is apparently the continuous activation of pathways that can also be sporadically activated and contribute to tumor development.
T14524 37799-37982 Sentence denotes The lymphomas were marked by the upregulation of IL10, constitutive activation of Stat3 signaling, and a requirement for activation of Akt, NFκB, and Stat3 pathways (Figures 5 and 7).
T14525 37983-38180 Sentence denotes Induction of IL10 is associated with the transformation of B-1 lymphomas in mice [59,60] and is frequently associated with EBV-positive B cell malignancies acting as a B cell growth factor [35–38].
T14526 38181-38282 Sentence denotes In addition, LMP1 has been shown to stimulate IL10 expression in Burkitt lymphoma cell lines [61,62].
T14527 38283-38489 Sentence denotes This suggests that although Stat3 is constitutively activated in the lymphoma cells, the induction of IL10 may further enhance Stat3 activation or may contribute to other IL10-responsive signaling pathways.
T14528 38490-38703 Sentence denotes LMP1 activates both the canonical and non-canonical pathways of NFκB signaling [14,63–65], and inhibition of NFκB blocked the survival of LMP1 transgenic lymphocytes and LMP1-positive and -negative lymphoma cells.
T14529 38704-38909 Sentence denotes NFκB and PI3K signaling are crucial for CD40-induced proliferation, and mice deficient for cRel or the p85 regulatory subunit of PI3K are unresponsive to mitogenic stimuli, including CD40 ligation [66–68].
T14530 38910-39101 Sentence denotes We have previously shown that cRel is specifically activated in both wild-type and LMP1 transgenic lymphomas, suggesting that activation of cRel is associated with B cell transformation [27].
T14531 39102-39285 Sentence denotes Our observations suggest that similar to CD40-induced proliferation, LMP1 induces proliferation through PI3K-mediated activation of Akt and activation of NFκB components such as cRel.
T14532 39286-39508 Sentence denotes CD40 also induces downregulation of the cell cycle inhibitor p27 through a PI3K-dependent manner, and the LMP1 lymphoma cells also had decreased levels of p27 with phosphorylation of Rb and increased Cdk2 (Figure 6C) [66].
T14533 39509-39676 Sentence denotes Although LMP1 has been shown to deregulate the Rb pathway in epithelial cells [69], to our knowledge this is the first demonstration of this property in B lymphocytes.
T14534 39677-39808 Sentence denotes The requirement for Akt activation was confirmed by the striking inhibition of lymphoma viability by triciribine, an Akt inhibitor.
T14535 39809-39928 Sentence denotes However, the activated pAkt did not lead to phosphorylation and inactivation of the downstream target GSK3 (Figure 6A).
T14536 39929-39998 Sentence denotes This effect has also been described in EBV-positive HD biopsies [40].
T14537 39999-40178 Sentence denotes In contrast, rapamycin, U0126, and SB202190 did not affect the survival of LMP1 transgenic lymphocytes or the wild-type and LMP1 transgenic lymphoma cells (Figure 7A, 7C, and 7E).
T14538 40179-40273 Sentence denotes This lack of effect by rapamycin confirmed the absence of activated p-mTOR levels (Figure 6B).
T14539 40274-40356 Sentence denotes These findings suggest that other Akt targets contribute to malignant progression.
T14540 40357-40432 Sentence denotes One key target is likely the inhibition of the Fox01 transcription factors.
T14541 40433-40609 Sentence denotes Repression of the pro-apoptotic transcription factor FoxO1 in a PI3K-dependent manner can inhibit expression of bcl6, a transcription factor necessary for GC formation [49,70].
T14542 40610-40720 Sentence denotes It has been shown that overstimulation of CD40 signaling with agonistic antibodies inhibits GC formation [71].
T14543 40721-40830 Sentence denotes Similarly, due to mimicry of CD40 signaling, transgenic LMP1 mice are also defective in GC formation [23,49].
T14544 40831-40924 Sentence denotes The constitutive signaling by LMP1 likely blocks GC formation through downregulation of bcl6.
T14545 40925-41057 Sentence denotes Interestingly, clinical studies indicate that expression of LMP1 and bcl6 are mutually exclusive in non-HD and classical HD [72,73].
T14546 41058-41127 Sentence denotes Thus, the LMP1 transgenic lymphomas mirror aspects of EBV-induced HD.
T14547 41128-41418 Sentence denotes Although the activation of Akt and the lack of Fox01 in the lymphoma cells suggest that LMP1 affects bcl6 and GC formation through this pathway, regulation of other Forkhead targets involved in cell cycle progression, such as p27 and CyclinD2, likely contribute to malignant transformation.
T14548 41419-41519 Sentence denotes Indeed, loss of FoxO1 expression in lymphoma cells correlated with a loss of p27 (Figure 6B and 6C).
T14549 41520-41625 Sentence denotes CyclinD2 has also been shown to be upregulated by LMP1 through release of FoxO1-mediated repression [70].
T14550 41626-41785 Sentence denotes In summary, in this transgenic model of lymphomagenesis, LMP1 promotes malignancy in B-1a cells, a population that is predisposed to clonal expansion with age.
T14551 41786-42012 Sentence denotes The malignant lymphocytes were distinguished by constitutively active Stat3 signaling, decreased p27, and activated Akt and NFκB pathways, properties that are associated with promoting the growth and survival of B lymphocytes.
T14552 42013-42181 Sentence denotes Importantly, Akt, NFκB, and Stat3 pathways were critically required for the growth and survival of malignant lymphocytes as well as healthy LMP1 transgenic lymphocytes.
T14553 42182-42351 Sentence denotes The growth of EBV-transformed lymphocytes also requires activation of NFκB, and these studies provide insight into how LMP1 contributes to EBV-associated transformation.
T14554 42352-42520 Sentence denotes The transgenic lymphomas mirror multiple aspects of EBV-induced tumors and suggest that in vivo these properties of LMP1 are major factors in the development of cancer.
T18288 42545-42561 Sentence denotes Transgenic mice.
T18289 42562-42728 Sentence denotes Generation of LMP1 mice under the Ig heavy chain promoter and enhancer have been described previously and were maintained as heterozygotes on a Balbc background [26].
T18290 42729-42829 Sentence denotes LMP1 mice were genotyped by Southern blot and PCR analysis of tail DNA as described previously [26].
T18291 42830-43005 Sentence denotes Spleen and liver sections were fixed in 4% paraformaldehyde and embedded in paraffin, and 5-μm sections were stained with hematoxylin and eosin for histopathological analysis.
T18292 43006-43152 Sentence denotes Lymphomas were passaged by intraperitoneal injection of 1 × 108 splenocytes into SCID mice and sacrificed upon development of an extended abdomen.
T18293 43153-43397 Sentence denotes Animals were housed in the Association for Assessment and Accreditation for Animal Care–approved animal facility at the University of North Carolina at Chapel Hill. All protocols were approved by the Institutional Animal Care and Use Committee.
T18609 43399-43431 Sentence denotes Isolation and growth of B cells.
T18610 43432-43567 Sentence denotes Splenocytes were prepared by homogenizing spleen tissue with two frosted slides and debris was filtered through a 100-μm cell strainer.
T18611 43568-43698 Sentence denotes Erythrocytes were lysed using 0.8% ammonium chloride solution (StemCell Technologies) for 10 min on ice and washed twice with PBS.
T18612 43699-43928 Sentence denotes B cells were isolated using CD19-MACS beads according to the manufacturer's instructions (Miltenyi Biotec) and grown in Iscove's medium supplemented with heat-inactivated 10% fetal bovine serum and antibiotic/antimycotic (GIBCO).
T18613 43929-44098 Sentence denotes Splenocytes isolated from SCID-passaged lymphomas consisted of 80%–90% B cells as determined by flow cytometry, and were hence not further purified with CD19-MACS beads.
T18614 44099-44334 Sentence denotes Splenocytes were seeded at 1.25 × 106 cells/ml and where applicable, recombinant mouse IL4 was added at 100 ng/ml, recombinant mouse IL10 at 10 ng/ml, and rat IgG1 anti-mouse IL10 and rat IgG1 isotype control at 10 μg/ml (R&D Systems).
T18615 44335-44432 Sentence denotes For BrdU incorporation assays, splenocytes were pulsed for 24 h with 10 μM BrdU 1 d post-harvest.
T19038 44434-44444 Sentence denotes MTS assay.
T19039 44445-44731 Sentence denotes The 3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) cell cytotoxicity/proliferation assays were performed using the CellTiter 96 aqueous one-solution cell proliferation assay (Promega), according to manufacturer's instructions.
T19040 44732-44827 Sentence denotes For IL4 studies, splenocytes were cultured for 3 d in the presence or absence of 100 ng/ml IL4.
T19041 44828-44929 Sentence denotes Cells were seeded on day 3 in triplicate in a 96-well plate at 2.5 × 106 cells/ml at 100 μl per well.
T19042 44930-45038 Sentence denotes MTS reagent was added for 4 h and absorbance was read at 540 nm; values plotted were subtracted from blanks.
T19043 45039-45281 Sentence denotes For neutralization assays, splenocytes were seeded at 5 × 106 cells/ml at 100 μl per well on day of harvest and IL4, rat IgG1 anti-mouse IL4, or rat IgG1 isotype control (R&D Systems) were added at the concentrations indicated in the figures.
T19044 45282-45345 Sentence denotes Cultures were pulsed for 4 h with MTS reagent 1 d post-seeding.
T19045 45346-45524 Sentence denotes For inhibitor studies, splenocytes were seeded at 1 × 107 cells/ml at 100 μl per well on day of harvest, and inhibitors were added at the concentrations indicated in the figures.
T19046 45525-45787 Sentence denotes The inhibitors BAY11–7085, rapamycin, triciribine, U0126, SB202190, and cucurbitacin I were purchased from EMD Biosciences. For non-malignant splenocyte cultures, B cell activation was induced with 10 μg/ml of goat F(ab') anti-mouse IgM (Jackson ImmunoResearch).
T19047 45788-45851 Sentence denotes Cultures were pulsed for 4 h with MTS reagent 1 d post-seeding.
T19642 45853-45874 Sentence denotes Immunohistochemistry.
T19643 45875-45999 Sentence denotes Paraffin-embedded spleen sections were deparaffinized in Histoclear (National Diagnostics) and rehydrated in graded ethanol.
T19644 46000-46130 Sentence denotes Sections were antigen retrieved by microwaving in citrate buffer (pH 6.0) for 15 min (LMP1 staining) and 10 min (pStat3 staining).
T19645 46131-46270 Sentence denotes For LMP1 staining, sections were blocked with 1% BSA and 0.1% cold fish skin gelatin followed with streptavidin/biotin block (Vector Labs).
T19646 46271-46582 Sentence denotes Rat IgG anti-LMP1 (clones 8G3 and 1G6, Ascenion) were used at 1:10 dilution from tissue culture supernatants, followed with 8 μg/ml biotinylated mouse F(ab') anti-rat IgG (H+L) pre-adsorbed to mouse serum (Jackson ImmunoResearch) and 2 μg/ml streptavidin-alkaline phosphatase conjugate (Jackson ImmunoResearch).
T19647 46583-46665 Sentence denotes Stains were developed with BCIP/NBT and counterstained in Nuclear Fast Red (Dako).
T19648 46666-46818 Sentence denotes Phospho-Stat3 was detected with 4 μg/ml of pStat3 antibody (Tyr705, Cell Signaling) and detected with anti-rabbit Poly-HRP IHC detection kit (Chemicon).
T20038 46820-46835 Sentence denotes Flow cytometry.
T20039 46836-47000 Sentence denotes One million splenocytes were stained with the appropriate primary antibody unconjugated or conjugated to FITC, PE, or APC diluted in stain buffer (PBS with 3% FBS).
T20040 47001-47103 Sentence denotes For BrdU detection, the FITC-BrdU flow kit was used as instructed by the manufacturer (BD Bioscience).
T20041 47104-47275 Sentence denotes Briefly, cells were exposed to EMA (Molecular Probes) for exclusion of dead cells, stained for surface antigens, fixed in paraformaldehyde, and permeabilized with saponin.
T20042 47276-47383 Sentence denotes To expose BrdU epitopes, cells were treated with Dnase and stained with FITC-conjugated anti-BrdU antibody.
T20043 47384-47475 Sentence denotes Flow cytometry was performed on FACScalibur using the CellQuest program (Becton Dickinson).
T20044 47476-47541 Sentence denotes Further analysis was conducted on the Summit v4.2 program (Dako).
T20334 47543-47566 Sentence denotes Rnase protection assay.
T20335 47567-47738 Sentence denotes Total RNA was isolated from CD19+ MACS-purified B cells using the Rneasy midi purification kit with Dnase treatment, according to the manufacturer's instructions (Qiagen).
T20336 47739-47896 Sentence denotes The mCK-1 probe template set (BD Biosciences) was labeled using the In Vitro Transcription Kit according to the manufacturer's instructions (BD Biosciences).
T20337 47897-48054 Sentence denotes Briefly, 50 ng of mCK-1 probe set was labeled with [α-32P]UTP using T7 RNA polymerase and purified using Sephadex G-50 columns (NucAway Spin column, Ambion).
T20338 48055-48224 Sentence denotes The labeled probe was quantitated using a scintillation counter, and 6 × 105 cherenkov cpm was used to hybridize to 4 μg of total RNA using the RPA kit (BD Biosciences).
T20339 48225-48291 Sentence denotes Samples were denatured at 90 °C and hybridized at 56 °C overnight.
T20340 48292-48394 Sentence denotes Single-stranded RNA was digested with a mixture of Rnase A and T1, and precipitated using isopropanol.
T20341 48395-48526 Sentence denotes Protected probes were resolved on a denaturing 4.75% acrylamide gel, dried, and imaged using a phosphorImager (Molecular Dynamics).
T20342 48527-48609 Sentence denotes Densitometry was performed using the ImageQuant TL v2005 software (GE Healthcare).
T20768 48611-48649 Sentence denotes PCR analysis of κ chain rearrangement.
T20769 48650-48743 Sentence denotes DNA was isolated from splenocytes using the Dneasy Tissue Kit (Qiagen), with Rnase treatment.
T20770 48744-48899 Sentence denotes PCR reactions contained 100 ng of genomic DNA, 0.2 μM each primer, 0.2 mM dNTPs, and 2.5 U Taq DNA polymerase (NEB) performed in 1X ThermoPol buffer (NEB).
T20771 48900-48975 Sentence denotes Primers used were Vκcon and Jκ5–1° and have been described previously [74].
T20772 48976-49118 Sentence denotes PCR conditions were 94 °C for 2 min, 40 cycles of 94 °C for 30 s, 63 °C for 90 s, and 72 °C for 1 min, followed by 1 cycle of 72 °C for 5 min.
T21027 49120-49140 Sentence denotes Immunoblot analysis.
T21028 49141-49444 Sentence denotes Whole cell lysates were prepared in radioimmunoprecipitation assay (RIPA) buffer (20 mM Tris-HCl [pH 7.5], 150 mM NaCl, 1 mM EDTA, 1% NP-40, 0.1% SDS, 0.1% sodium deoxycholate) supplemented with 2 mM phenylmethylsulfonyl fluoride, 1 mM Na3VO4, and 1:100 protease/phosphatase inhibitor cocktails (Sigma).
T21029 49445-49566 Sentence denotes Crude lysates were centrifuged at 13,000 rpm for 10 min at 4 °C and the supernatants were collected for further analysis.
T21030 49567-49647 Sentence denotes Protein concentrations were determined with the Bio-Rad DC protein assay system.
T21031 49648-49840 Sentence denotes Lysates were boiled in the presence of 2.5% β-mecaptoethanol, separated by denaturing SDS-PAGE, and transferred to 0.45-μm Optitran membranes (Schleicher & Schuell) in a Bio-Rad transfer unit.
T21032 49841-50063 Sentence denotes Membranes were immunoblotted with the appropriate primary antibody followed by horseradish peroxidase–tagged secondary antibodies (Amersham Biosciences and Dako) and detected with the SuperSignal West Pico System (Pierce).
T21448 50065-50076 Sentence denotes Antibodies.
T21449 50077-50668 Sentence denotes FITC-conjugated goat anti-mouse IgM, rat IgG2aκ anti-mouse IgD (clone 11–26), rat IgG1κ anti-mouse kappa (clone 187.1), rat IgG2bκ anti-mouse lambda (clone JC5–1); PE-conjugated goat anti-mouse IgG; un-conjugated goat anti-mouse kappa and anti-mouse lambda were purchased from Southern Biotech. APC-conjugated rat IgG2aκ anti-mouse CD19 (clone 6D5), PE-conjugated mouse IgG2aκ anti-LMP1 (clone S12), un-conjugated mouse IgG2a anti-Rb (clone 2), and anti-Cdk2 (clone 55) were purchased from BD Bioscience. PE-conjugated rat IgG2aκ anti-mouse CD5 (clone 53–7.3) was purchased from eBioscience.
T21450 50669-51190 Sentence denotes Rat anti-LMP1 (clones 8G3, 1G6, 7E10, and 7G8) was purchased from Ascenion. Rabbit anti-pAkt (Ser473), anti-pGSK3α/β (Ser21/9), anti-pStat3 (Tyr705), anti-pStat6 (Tyr641), anti-pmTOR (Ser2448), anti-Stat6, anti-Akt, anti-FoxO1, and anti-p27 were purchased from Cell Signaling. Rabbit anti-Stat3 (H-190), anti-IκBα (C-21), and goat anti-β actin (I-19) were purchased from Santa Cruz Biotechnology. Mouse IgG1κ anti-GSK3 was purchased from Upstate Biotechnology. Rabbit anti-pRb (Thr373) was purchased from EMD Biosciences.
T21805 8478-8542 Sentence denotes High LMP1 Expression Correlates with the Development of Lymphoma
T21806 8543-8718 Sentence denotes LMP1 expression is shown by (A) immunoblotting of purified B cells (CD19+) and (B) immunohistochemistry staining of spleen tissue from wild-type (WT) and LMP1 transgenic mice.
T21807 8719-8768 Sentence denotes (A) Lymphomas are identified with a number (1–7).
T21808 8769-8868 Sentence denotes Arrows indicate the LMP1-specific band and its degradation products as well as a non-specific band.
T21809 8869-8905 Sentence denotes Actin was used as a loading control.
T21810 8906-9000 Sentence denotes (B) White and red pulps are shown, but this architecture is lost upon development of lymphoma.
T21811 9001-9018 Sentence denotes Scale bar, 20 μm.
T22113 10554-10616 Sentence denotes LMP1 Promotes B-1a Lymphomas That Can Escape Allelic Exclusion
T22114 10617-10809 Sentence denotes (A) Flow cytometry analysis of splenocytes from a WT or LMP1 transgenic lymphoma for the pan–B cell (CD19), B-1a cell (CD5), and Ig heavy chain (IgM and IgD) and light chain (κ and λ) markers.
T22115 10810-10882 Sentence denotes Shown are the results from WT lymphoma 1 and LMP1 transgenic lymphoma 4.
T22116 10883-11079 Sentence denotes This analysis was repeated on four other LMP1 transgenic lymphomas (1, 2, 3, and 6) showing a similar B-1a phenotype, of which lymphomas 2 and 4 were also doubly positive for κ and λ light chains.
T22117 11080-11201 Sentence denotes (B) Flow cytometry analysis of WT or LMP1 transgenic splenocytes for B-1a (CD19+CD5+) and B-1b or B2 subsets (CD19+CD5−).
T22118 11202-11272 Sentence denotes Percentages of B-1a and B-1b or B2 subsets are shown in each quadrant.
T22119 11273-11374 Sentence denotes This analysis was repeated on three other WT and two other LMP1 transgenic mice with similar results.
T22120 11375-11485 Sentence denotes (C) Immunoblot analysis for κ and λ light chains of B cells (CD19+) purified from WT and LMP1 transgenic mice.
T22121 11486-11522 Sentence denotes Actin was used as a loading control.
T22656 14367-14423 Sentence denotes LMP1 Promotes B Cell Survival and Proliferation In Vitro
T22657 14424-14486 Sentence denotes (A) MTS assay of splenocytes from WT and LMP1 transgenic mice.
T22658 14487-14580 Sentence denotes Splenocytes were cultured in the presence (grey bars) or absence (black bars) of IL4 for 3 d.
T22659 14581-14839 Sentence denotes The results are the mean ± SEM of triplicate samples averaged from multiple mice where “n” the number of mice analyzed is as follows: n = 2 for WT lymphocytes and WT lymphomas, n = 11 for LMP1 transgenic lymphocytes, and n = 13 for LMP1 transgenic lymphomas.
T22660 14840-15018 Sentence denotes (B) EMA exclusion of CD19+ gated splenocytes from WT and LMP1 transgenic mice showing percentage of viable B cells cultured with (white bars) or without (black bars) IL4 for 2 d.
T22661 15019-15147 Sentence denotes (C) Flow cytometry analysis for incorporated BrdU in WT and LMP1 transgenic lymphoma cells cultured with or without IL4 for 2 d.
T22662 15148-15220 Sentence denotes Shown are the results from WT lymphoma 1 and LMP1 transgenic lymphoma 2.
T22663 15221-15269 Sentence denotes Percentages of cells in each quadrant are shown.
T23143 17941-18041 Sentence denotes Wild-Type and LMP1 Transgenic Lymphoma Cells Survive Independently of IL4/Stat6 Signaling in Culture
T23144 18042-18152 Sentence denotes (A) Rnase protection assay for IL4 mRNA from purified B cells (CD19+) from WT and LMP1 transgenic splenocytes.
T23145 18153-18221 Sentence denotes The L32 and GAPDH housekeeping genes were used as a loading control.
T23146 18222-18274 Sentence denotes Arrow indicates the position of the protected probe.
T23147 18275-18585 Sentence denotes (B and C) Immunoblot analysis of WT and LMP1 transgenic mice for activated pStat6 in (B) purified B cells (CD19+) at the time of harvest or in (C) whole splenocytes cultured with or without IL4. (B) Actin was used as a loading control, and the white line indicates that intervening lanes have been spliced out.
T23148 18586-18779 Sentence denotes (D and E) MTS assay of (D) WT lymphocytes and (E) LMP1 transgenic lymphoma cells cultured with IL4, a neutralizing antibody to IL4, or a rat IgG isotype control at the indicated concentrations.
T23149 18780-18834 Sentence denotes Shown are the results from LMP1 transgenic lymphoma 3.
T23150 18835-18973 Sentence denotes The results are the mean ± SEM of triplicate samples from a single representative experiment that was repeated twice with similar results.
T23731 22890-22957 Sentence denotes LMP1 Upregulates IL10 Expression and Constitutively Activates Stat3
T23732 22958-23097 Sentence denotes (A) Relative expression of IL10, IL15, and IFNγ mRNA in WT and LMP1 transgenic B cells (CD19+), as detected with an Rnase protection assay.
T23733 23098-23159 Sentence denotes Mouse lymphoma cell lines 967 and K46μ were used as controls.
T23734 23160-23282 Sentence denotes Expression levels were quantified with a phosphorimager and values were normalized to the ribosomal housekeeping gene L32.
T23735 23283-23357 Sentence denotes The cytokine:L32 ratio was set to 1 in the mouse B cell lymphoma line 967.
T23736 23358-23684 Sentence denotes (B and C) Immunoblot analysis of activated pStat3 in purified B cells (CD19+) from WT and LMP1 transgenic mice (B) at the time of harvest, and (C) 4 h after culture with or without IL10, a neutralizing antibody to IL10, or a rat IgG1 isotype control. (C) Shown are the results for WT lymphoma 1 and LMP1 transgenic lymphoma 1.
T23737 23685-23748 Sentence denotes Arrows indicate the positions of the α and β isoforms of Stat3.
T23738 23749-23785 Sentence denotes Actin was used as a loading control.
T23739 23786-23895 Sentence denotes (D) Immunohistochemistry detection of activated nuclear pStat3 in the spleens of WT and LMP1 transgenic mice.
T23740 23896-23913 Sentence denotes Scale bar, 20 μm.
T24366 25723-25793 Sentence denotes LMP1 Activates Akt Signaling and Deregulates the Rb Cell Cycle Pathway
T24367 25794-26058 Sentence denotes (A and B) Immunoblot analysis of purified B cells (CD19+) from the spleens of WT and LMP1 transgenic mice for Akt signaling, probing for (A) activated pAkt and downstream targets, including inactivated pGSK3α/β, and (B) activated p-mTOR, and total levels of FoxO1.
T24368 26059-26117 Sentence denotes Arrows indicate the positions of α and β isoforms of GSK3.
T24369 26118-26188 Sentence denotes The white line indicates that intervening lanes have been spliced out.
T24370 26189-26342 Sentence denotes (C) Immunoblot analysis for cell cycle proteins regulating the Rb pathway, probing for activated pRb, and total levels of Cdk2 and the Cdk inhibitor p27.
T24371 26343-26379 Sentence denotes Actin was used as a loading control.
T24794 30201-30290 Sentence denotes Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells
T24795 30291-30415 Sentence denotes MTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes.
T24796 30416-30623 Sentence denotes Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations.
T24797 30624-30677 Sentence denotes The results are the mean ± SEM of triplicate samples.
T24798 30678-30826 Sentence denotes Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed.
T24799 30827-30911 Sentence denotes This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.
T25238 30922-31024 Sentence denotes Analysis of Akt, NFκB, and Stat3 Pathways in Contribution to the Growth and Survival of Lymphoma Cells
T25239 31025-31311 Sentence denotes (A–D) Immunoblot analysis of wild-type and LMP1 transgenic lymphomas for Akt, NFκB, and Stat3 signaling after treatment with (A) an Akt inhibitor, triciribine, (B) an NFκB inhibitor, BAY11–7085, and the Stat3 inhibitors (C) cucurbitacin I and (D) AG490, at the indicated concentrations.
T25240 31312-31371 Sentence denotes Arrows indicate the positions of α and β isoforms of Stat3.
T25241 31372-31408 Sentence denotes Actin was used as a loading control.
T25509 16904-16976 Sentence denotes Summary of Analysis Performed on Wild-Type and LMP1 Transgenic Lymphomas
T14502 34135-34223 Sentence denotes This study defines the oncogenic properties of LMP1 in promoting B cell lymphomagenesis.
T14503 34224-34450 Sentence denotes LMP1 transgenic mice have a higher incidence of lymphoma [26] and the progression to lymphoma correlates with higher expression levels of LMP1 (Figure 1A and 1B), suggesting that LMP1 is directly involved in tumor development.
T14504 34451-34574 Sentence denotes Table 1 summarizes the biological and molecular properties that were identified in wild-type and LMP1 transgenic lymphomas.
T14505 34575-34838 Sentence denotes Although many of the molecular properties studied were similar between wild-type and LMP1 transgenic lymphomas, there were distinguishing biological properties, namely the ability of LMP1 transgenic lymphomas to induce higher levels of survival and proliferation.
T14506 34839-35069 Sentence denotes Interestingly, although LMP1 transgenic mice develop lymphomas in the same B-1a cell type as spontaneous wild-type lymphomas (Figure 2), some signaling effects induced by LMP1 may explain the enhanced promotion to lymphomagenesis.
T14507 35070-35310 Sentence denotes Since CD40-deficient mice have decreased numbers of IgMhighIgDlow cells, a phenotype associated with B-1, marginal zone, and memory B cells, the mimicry of CD40 signaling by LMP1 could possibly contribute to the expansion of B-1 cells [20].
T14508 35311-35500 Sentence denotes It is noteworthy that expression of LMP1 in transgenic mice has been shown to inhibit the formation of GCs [23,49], preventing typical B-2 cells from antigen-driven selection and expansion.
T14509 35501-35604 Sentence denotes The lack of GC reactions may contribute to the bias of LMP1 transgenic mice towards B-1 cell lymphomas.
T14510 35605-35722 Sentence denotes Interestingly, LMP2 signaling also favors development of B-1 cells, but this occurs in the absence of transformation.
T14511 35723-35867 Sentence denotes These results suggest that the mimicry of B cell receptor signaling by LMP2 promotes B-1 cell differentiation but not transformation [24,50,51].
T14512 35868-36005 Sentence denotes This promotion of B-1 differentiation may account for the ability of LMP2 to exacerbate autoimmunity and bypass anergy induction [52,53].
T14513 36006-36248 Sentence denotes In contrast, the preponderance of tumors of B-1a origin does not reflect effects of LMP1 signaling on B cell differentiation, as splenic B cells from healthy LMP1 transgenic mice contain similar numbers of B-1 and B-2 cells as wild-type mice.
T14514 36249-36380 Sentence denotes In support of this lack of effect, the differentiation of B-1 versus B-2 cells is thought to be independent of CD40 signaling [54].
T14515 36381-36571 Sentence denotes B-1 cells constitute the predominant lymphocyte population in the peritoneal and pleuropericardial cavities, while B-2 cells are mainly found in the spleen, lymph node, and peripheral blood.
T1 0-129 Sentence denotes EBV Latent Membrane Protein 1 Activates Akt, NFκB, and Stat3 in B Cell Lymphomas LMP1 Activates Akt, NFκB, and Stat3 in Lymphomas
T2 132-140 Sentence denotes Abstract
T3 141-227 Sentence denotes Latent membrane protein 1 (LMP1) is the major oncoprotein of Epstein-Barr virus (EBV).
T4 228-309 Sentence denotes In transgenic mice, LMP1 promotes increased lymphoma development by 12 mo of age.
T5 310-439 Sentence denotes This study reveals that lymphoma develops in B-1a lymphocytes, a population that is associated with transformation in older mice.
T6 440-623 Sentence denotes The lymphoma cells have deregulated cell cycle markers, and inhibitors of Akt, NFκB, and Stat3 block the enhanced viability of LMP1 transgenic lymphocytes and lymphoma cells in vitro.
T7 624-760 Sentence denotes Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling.
T8 761-881 Sentence denotes These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition.
T9 882-1022 Sentence denotes These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.
T10 1024-1038 Sentence denotes Author Summary
T11 1040-1197 Sentence denotes Epstein-Barr virus (EBV) is linked to the development of multiple cancers, including post-transplant lymphoma, Hodgkin disease, and nasopharyngeal carcinoma.
T12 1198-1379 Sentence denotes Latent membrane protein 1 (LMP1) is expressed in many EBV-associated cancers and is responsible for most of the altered cellular growth properties that are induced by EBV infection.
T13 1380-1511 Sentence denotes This study reveals that LMP1 induces lymphomas in B-1a lymphocytes, a cell type that is susceptible to transformation in aged mice.
T14 1512-1598 Sentence denotes The lymphomas require Akt, NFκB, and Stat3 signaling for enhanced growth and survival.
T15 1599-1734 Sentence denotes The activation of the Stat3, Akt, and NFκB signaling pathways likely underlies the ability of LMP1 to promote malignant transformation.
T16 1737-1749 Sentence denotes Introduction
T17 1750-1923 Sentence denotes Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus that infects humans predominantly at an early age with greater than 90% of the adult population infected with EBV [1].
T18 1924-2210 Sentence denotes EBV is linked to the development of both B lymphocyte and epithelial cell malignancies, including Burkitt lymphoma, Hodgkin disease (HD), and nasopharyngeal carcinoma (NPC), and cancers linked to immunosuppression, including post-transplant lymphoma and AIDS-associated lymphomas [2,3].
T19 2211-2395 Sentence denotes In vitro infection of B lymphocytes with EBV induces permanent growth transformation, and this ability to affect cell growth regulation likely contributes to the development of cancer.
T20 2396-2640 Sentence denotes Many of the viral proteins expressed in transformed cells, including the EBV nuclear antigens and latent membrane proteins, have profound effects on cell growth regulation and are required for EBV latent infection and B cell transformation [1].
T21 2641-2860 Sentence denotes Latent membrane protein 1 (LMP1) is considered the major oncoprotein of EBV, as it transforms rodent fibroblasts to tumorigenicity in nude mice and is expressed in HD, NPC, and immunosuppression-associated tumors [4–8].
T22 2861-2990 Sentence denotes In B lymphocytes, LMP1 mimics CD40 signaling, and both LMP1 and CD40 are essential for EBV-mediated B cell transformation [9–11].
T23 2991-3187 Sentence denotes While CD40 interacts with CD40 ligand expressed on activated T cells to induce B cell activation and differentiation, LMP1 acts as a constitutive signal through ligand-independent oligomerization.
T24 3188-3385 Sentence denotes LMP1 and CD40 interact with the same tumor necrosis factor receptor–associated factors (TRAFs) leading to activation of NFκB, c-Jun N terminal kinase (JNK), and p38 MAPK signaling pathways [12–16].
T25 3386-3512 Sentence denotes Activation of NFκB is required for EBV-induced B cell transformation and its inhibition rapidly results in cell death [17,18].
T26 3513-3712 Sentence denotes Recent studies indicate that LMP1 also activates phosphatidylinositol 3 kinase (PI3K)/Akt signaling and that this activation is required for LMP1-mediated transformation of rodent fibroblasts [5,19].
T27 3713-3808 Sentence denotes In vitro, primary B cells can be maintained by CD40 ligation in combination with IL4 treatment.
T28 3809-3996 Sentence denotes In vivo, CD40 signaling is necessary for germinal center (GC) formation such that mice deficient for CD40 or CD40L are unable to form GCs in response to T cell–dependent antigens [20,21].
T29 3997-4272 Sentence denotes Both the membrane proximal and distal cytoplasmic regions of CD40 that bind TRAF6 and TRAFs2/3/5, respectively, are necessary for GC formation, but either region is sufficient to induce extrafollicular B cell differentiation and restore low affinity antibody production [22].
T30 4273-4527 Sentence denotes Functionally, LMP1 can rescue CD40-deficient mice and restore immunoglobulin (Ig) class switching, most likely because LMP1 recruits similar TRAF molecules, TRAFs 1/2/3/5 and TRAF6, through the C-terminal activation regions 1 and 2 domains, respectively.
T31 4528-4605 Sentence denotes However, LMP1 is unable to restore affinity maturation and GC formation [23].
T32 4606-4816 Sentence denotes Several EBV transforming proteins have been studied in transgenic mouse models, however, only LMP1 induces tumor development when expressed under the control of the Ig heavy chain promoter and enhancer [24–26].
T33 4817-5066 Sentence denotes The LMP1 transgenic mice (IgLMP1) express LMP1 in B lymphocytes, and in mice older than 12 mo, lymphoma develops with increased incidence (40%–50%) compared to wild-type control mice (11%), suggesting that LMP1 contributes to tumor development [26].
T34 5067-5216 Sentence denotes The LMP1 lymphomas have rearranged Ig genes and have activated Akt, JNK, p38, and NFκB, with specific activation of the NFκB family member cRel [27].
T35 5217-5358 Sentence denotes In this study, the LMP1 transgenic lymphocytes and lymphomas were further characterized and their growth properties in vitro were determined.
T36 5359-5533 Sentence denotes To obtain pure populations of malignant lymphocytes and to enable more detailed biochemical analyses, examples of primary lymphomas were inoculated and passaged in SCID mice.
T37 5534-5683 Sentence denotes Interestingly, lymphoma development was restricted to B-1a lymphocytes, a self-replenishing population of cells that are prone to malignancy [28,29].
T38 5684-5796 Sentence denotes LMP1 transgenic lymphocytes had increased viability in vitro and viability was increased by the addition of IL4.
T39 5797-5996 Sentence denotes In contrast, both LMP1-positive and -negative lymphoma cells were independent of IL4 co-stimulation for survival and proliferation in vitro with a complete absence of activated Stat6, the IL4 target.
T40 5997-6117 Sentence denotes The lymphomas were also distinguished by constitutive activation of Stat3 and deregulation of the Rb cell cycle pathway.
T41 6118-6334 Sentence denotes Inhibition of the PI3K/Akt, NFκB, and Stat3 signaling pathways blocked the enhanced growth of both LMP1 transgenic and malignant lymphocytes, suggesting that these pathways are required for their growth and survival.
T42 6335-6472 Sentence denotes These appear to be the same targets that are deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition.
T43 6473-6673 Sentence denotes This study reveals that LMP1 promotes malignancy in cells with the inherent ability to proliferate and that the Akt, NFκB, and Stat3 signaling pathways are required for its growth stimulatory effects.
T44 6675-6682 Sentence denotes Results
T45 6684-6758 Sentence denotes High Levels of LMP1 Expression Correlates with the Development of Lymphoma
T46 6759-6876 Sentence denotes LMP1 expression in IgLMP1 mice was directed to B cells under the control of the Ig heavy chain promoter and enhancer.
T47 6877-7044 Sentence denotes It has previously been shown that in these transgenic mice, LMP1 expression was restricted to B220+ B cells with lymphoma detected in greatly enlarged spleens [23,26].
T48 7045-7285 Sentence denotes To investigate whether LMP1 expression contributes to lymphoma development, B cells were purified from splenocytes by positive selection using anti-CD19 MACS magnetic beads, and equivalent amounts of B cells were analyzed by immunoblotting.
T49 7286-7487 Sentence denotes LMP1 was detectable in LMP1 transgenic B cells, but upon development of lymphoma, LMP1 expression was stronger in 5/7 lymphomas analyzed with concomitant appearance of degradation products (Figure 1A).
T50 7488-7680 Sentence denotes To determine whether the higher level of LMP1 detected was due to an expansion of malignant lymphocytes, expression of LMP1 in the spleen was further evaluated by immunohistochemical staining.
T51 7681-7866 Sentence denotes Immunohistochemistry analysis of spleen sections detected LMP1 in the plasma membrane of cells in both the follicular white pulp and circulating lymphocytes in the red pulp (Figure 1B).
T52 7867-7995 Sentence denotes LMP1 expression was heterogeneous with strong LMP1 staining interspersed amongst a background of cells staining weakly for LMP1.
T53 7996-8115 Sentence denotes Upon development to lymphoma, LMP1 expression was more abundantly detected with multiple foci of intense LMP1 staining.
T54 8116-8312 Sentence denotes This demonstrates that the increased LMP1 detected by immunoblotting upon malignant progression reflects an increase in LMP1 expression and an accumulation of cells expressing high levels of LMP1.
T55 8313-8467 Sentence denotes This correlation between high LMP1 expression and the development of lymphoma suggests that progression to lymphoma results from increased levels of LMP1.
T56 8468-8542 Sentence denotes Figure 1 High LMP1 Expression Correlates with the Development of Lymphoma
T57 8543-8718 Sentence denotes LMP1 expression is shown by (A) immunoblotting of purified B cells (CD19+) and (B) immunohistochemistry staining of spleen tissue from wild-type (WT) and LMP1 transgenic mice.
T58 8719-8768 Sentence denotes (A) Lymphomas are identified with a number (1–7).
T59 8769-8868 Sentence denotes Arrows indicate the LMP1-specific band and its degradation products as well as a non-specific band.
T60 8869-8905 Sentence denotes Actin was used as a loading control.
T61 8906-9000 Sentence denotes (B) White and red pulps are shown, but this architecture is lost upon development of lymphoma.
T62 9001-9018 Sentence denotes Scale bar, 20 μm.
T63 9020-9082 Sentence denotes LMP1 Promotes B-1a Lymphomas That Can Escape Allelic Exclusion
T64 9083-9325 Sentence denotes To determine if LMP1 signaling affects B cell differentiation and to immunophenotype the lymphomas that arise from LMP1 expression, surface Ig expression of heavy chains (IgM, IgG, IgD) and light chains (κ, λ) were analyzed by flow cytometry.
T65 9326-9561 Sentence denotes Similar numbers of naïve (IgM+IgD+IgG−) splenic B cells with a strong bias towards κ light chain were detected from wild-type or LMP1 transgenic mice, indicating that LMP1 signaling does not affect B cell maturation (unpublished data).
T66 9562-9748 Sentence denotes Flow cytometry analysis of the SCID-passaged wild-type and LMP1 transgenic lymphomas revealed an IgMhighIgDlow phenotype (Figure 2A), indicative of marginal zone, B-1, or memory B cells.
T67 9749-9822 Sentence denotes B-1 cells are further separated into CD5+ (B-1a) and CD5− (B-1b) subsets.
T68 9823-9927 Sentence denotes To differentiate between these cell types, lymphoma cells were further analyzed for the B-1a marker CD5.
T69 9928-10084 Sentence denotes All (5/5) of the tested LMP1 transgenic lymphomas displayed an IgMhighIgDlowCD5+ phenotype (Figure 2A), an expression pattern that distinguishes B-1a cells.
T70 10085-10174 Sentence denotes Interestingly, a spontaneous wild-type lymphoma also developed in B-1a cells (Figure 2A).
T71 10175-10310 Sentence denotes These cells are an interesting population that is self replenishing with an increased likelihood to become malignant in aged mice [30].
T72 10311-10543 Sentence denotes Analysis of LMP1 transgenic mice before the development of lymphoma showed similar numbers of splenic B-1a (CD19+CD5+) and B-1b or B-2 populations (CD19+CD5−), indicating that LMP1 does not affect B cell differentiation (Figure 2B).
T73 10544-10616 Sentence denotes Figure 2 LMP1 Promotes B-1a Lymphomas That Can Escape Allelic Exclusion
T74 10617-10809 Sentence denotes (A) Flow cytometry analysis of splenocytes from a WT or LMP1 transgenic lymphoma for the pan–B cell (CD19), B-1a cell (CD5), and Ig heavy chain (IgM and IgD) and light chain (κ and λ) markers.
T75 10810-10882 Sentence denotes Shown are the results from WT lymphoma 1 and LMP1 transgenic lymphoma 4.
T76 10883-11079 Sentence denotes This analysis was repeated on four other LMP1 transgenic lymphomas (1, 2, 3, and 6) showing a similar B-1a phenotype, of which lymphomas 2 and 4 were also doubly positive for κ and λ light chains.
T77 11080-11201 Sentence denotes (B) Flow cytometry analysis of WT or LMP1 transgenic splenocytes for B-1a (CD19+CD5+) and B-1b or B2 subsets (CD19+CD5−).
T78 11202-11272 Sentence denotes Percentages of B-1a and B-1b or B2 subsets are shown in each quadrant.
T79 11273-11374 Sentence denotes This analysis was repeated on three other WT and two other LMP1 transgenic mice with similar results.
T80 11375-11485 Sentence denotes (C) Immunoblot analysis for κ and λ light chains of B cells (CD19+) purified from WT and LMP1 transgenic mice.
T81 11486-11522 Sentence denotes Actin was used as a loading control.
T82 11525-11703 Sentence denotes Due to allelic exclusion, mature B cells that have been exposed to antigen will typically express only one heavy chain isotype (IgG, IgE, or IgA) and either a κ or λ light chain.
T83 11704-11855 Sentence denotes Interestingly, 2/5 LMP1 transgenic lymphomas analyzed (lymphomas 2 and 4) were doubly positive for low levels of both κ and λ light chains (Figure 2A).
T84 11856-12108 Sentence denotes Previous characterization of the LMP1 lymphomas had revealed that the lymphomas were clonal as determined by Ig heavy chain rearrangement [26], and analysis of κ chain rearrangement (Figure S1) of the samples analyzed in this study confirmed clonality.
T85 12109-12239 Sentence denotes To further assess light chain expression, the passaged samples were tested by immunoblotting for κ and λ light chains (Figure 2C).
T86 12240-12338 Sentence denotes Interestingly, very low levels of expression of both light chains were detected by flow cytometry.
T87 12339-12478 Sentence denotes The low levels of expression may reflect a limitation of the total number of light chains that can be expressed on the surface of a B cell.
T88 12479-12698 Sentence denotes In agreement with the flow cytometry analysis, LMP1 transgenic lymphomas 2 and 4 were also positive for κ and λ light chains by immunoblot analysis (Figure 2C), confirming that these lymphomas express both light chains.
T89 12699-12887 Sentence denotes A previous study of mice that developed leukemia due to an expansion of self-reactive B-1a cells determined that the B-1a leukemias were also doubly positive for κ and λ light chains [31].
T90 12888-13050 Sentence denotes These findings indicate that expression of LMP1 in B-1a cells promotes the development of malignancy and can result in the aberrant escape from allelic exclusion.
T91 13052-13108 Sentence denotes LMP1 Promotes B Cell Survival and Proliferation In Vitro
T92 13109-13207 Sentence denotes Primary B cell cultures can be maintained through CD40 ligation and supplementation with IL4 [32].
T93 13208-13514 Sentence denotes To investigate whether LMP1 affects primary B cell survival and proliferation, splenocytes were cultured in the presence or absence of IL4 and analyzed by MTS as a metabolic marker, by ethidium monoazide (EMA) exclusion for viability, and by 5-bromo-2′-deoxy-uridine (BrdU) incorporation for proliferation.
T94 13515-13667 Sentence denotes In the MTS assay, as expected, splenocytes from wild-type mice did not survive even with the addition of IL4 due to a lack of CD40 ligation (Figure 3A).
T95 13668-13799 Sentence denotes In contrast, LMP1 splenocytes had increased metabolism even in the absence of IL4, which was further enhanced upon addition of IL4.
T96 13800-13916 Sentence denotes Wild-type and LMP1 transgenic lymphoma cells had high levels of MTS activity even in the absence of IL4 (Figure 3A).
T97 13917-14094 Sentence denotes The LMP1 transgenic lymphoma cells had approximately 4-fold higher MTS activity than the normal transgenic lymphocytes and were at least 2-fold higher than the control lymphoma.
T98 14095-14212 Sentence denotes As previously published, lymphoma usually develops in mice over 12 mo of age and all mice are sacrificed by 18–20 mo.
T99 14213-14301 Sentence denotes The ages of the transgenic mice with or without lymphoma ranged between 6 and 20 mo old.
T100 14302-14356 Sentence denotes There was no correlation between age and MTS activity.
T101 14357-14423 Sentence denotes Figure 3 LMP1 Promotes B Cell Survival and Proliferation In Vitro
T102 14424-14486 Sentence denotes (A) MTS assay of splenocytes from WT and LMP1 transgenic mice.
T103 14487-14580 Sentence denotes Splenocytes were cultured in the presence (grey bars) or absence (black bars) of IL4 for 3 d.
T104 14581-14839 Sentence denotes The results are the mean ± SEM of triplicate samples averaged from multiple mice where “n” the number of mice analyzed is as follows: n = 2 for WT lymphocytes and WT lymphomas, n = 11 for LMP1 transgenic lymphocytes, and n = 13 for LMP1 transgenic lymphomas.
T105 14840-15018 Sentence denotes (B) EMA exclusion of CD19+ gated splenocytes from WT and LMP1 transgenic mice showing percentage of viable B cells cultured with (white bars) or without (black bars) IL4 for 2 d.
T106 15019-15147 Sentence denotes (C) Flow cytometry analysis for incorporated BrdU in WT and LMP1 transgenic lymphoma cells cultured with or without IL4 for 2 d.
T107 15148-15220 Sentence denotes Shown are the results from WT lymphoma 1 and LMP1 transgenic lymphoma 2.
T108 15221-15269 Sentence denotes Percentages of cells in each quadrant are shown.
T109 15272-15476 Sentence denotes EMA exclusion of CD19+ gated B cells prepared from two wild-type and two LMP1 transgenic mice indicated a 2-fold increase in viability in the LMP1 transgenic lymphocytes compared to wild-type lymphocytes.
T110 15477-15682 Sentence denotes Two examples of LMP1 transgenic lymphoma cells had greatly increased viability that was not increased by IL4 treatment, indicating that the lymphoma cells are independent of IL4 co-stimulation (Figure 3B).
T111 15683-15839 Sentence denotes Enhancement in MTS activity was observed in LMP1 transgenic lymphoma cells by the addition of IL4; however, EMA exclusion did not reveal a similar increase.
T112 15840-15973 Sentence denotes This could reflect a difference for IL4 requirement in the metabolic activity versus the viability of LMP1 transgenic lymphoma cells.
T113 15974-16191 Sentence denotes Although expression of LMP1 could enhance survival of non-malignant primary lymphocytes, BrdU incorporation revealed that LMP1 expression alone was not sufficient to induce proliferation in culture (unpublished data).
T114 16192-16295 Sentence denotes Only lymphoma cells had detectable levels of BrdU incorporation detected by flow cytometry (Figure 3C).
T115 16296-16484 Sentence denotes Interestingly, LMP1 lymphoma cells had significantly higher levels of proliferation in comparison to the spontaneous lymphoma that developed in an LMP1-negative littermate (25% versus 4%).
T116 16485-16744 Sentence denotes This higher level of proliferation was observed in lymphomas that express both high (Table 1, LMP1-L2 and LMP1-L3) and low (Table 1, LMP1-L5) levels of LMP1, suggesting that even small amounts of LMP1 is sufficient to induce dramatic effects in proliferation.
T117 16745-16894 Sentence denotes The level of proliferation was not enhanced upon IL4 addition, confirming the IL4 independence observed in the viability studies (Figure 3C; Table1).
T118 16895-16976 Sentence denotes Table 1 Summary of Analysis Performed on Wild-Type and LMP1 Transgenic Lymphomas
T119 16978-17061 Sentence denotes Wild-Type and LMP1 Transgenic Lymphoma Cells Do Not Require IL4 and Stat6 Signaling
T120 17062-17206 Sentence denotes To investigate whether IL4 independence was due to endogenous IL4 expression, IL4 transcription was assessed by an Rnase protection assay (RPA).
T121 17207-17318 Sentence denotes IL4 transcription was detectable with control RNA and faintly in the mouse lymphoma cell line K46μ (Figure 4A).
T122 17319-17566 Sentence denotes However, IL4 transcription was not detectable in CD19+ MACS-purified B cells from wild-type lymphocytes (unpublished data), LMP1 transgenic lymphocytes, or lymphoma cells, although the GAPDH and L32 controls were effectively protected (Figure 4A).
T123 17567-17705 Sentence denotes Activated Stat6 (pStat6), a target of the IL4 receptor pathway, was detected in the wild-type and LMP1 transgenic lymphocytes (Figure 4B).
T124 17706-17804 Sentence denotes In contrast, pStat6 was barely detected in either the wild-type or LMP1 transgenic lymphoma cells.
T125 17805-17930 Sentence denotes However, the pathway was not disabled, as treatment of the lymphoma cells with IL4 induced Stat6 phosphorylation (Figure 4C).
T126 17931-18041 Sentence denotes Figure 4 Wild-Type and LMP1 Transgenic Lymphoma Cells Survive Independently of IL4/Stat6 Signaling in Culture
T127 18042-18152 Sentence denotes (A) Rnase protection assay for IL4 mRNA from purified B cells (CD19+) from WT and LMP1 transgenic splenocytes.
T128 18153-18221 Sentence denotes The L32 and GAPDH housekeeping genes were used as a loading control.
T129 18222-18274 Sentence denotes Arrow indicates the position of the protected probe.
T130 18275-18585 Sentence denotes (B and C) Immunoblot analysis of WT and LMP1 transgenic mice for activated pStat6 in (B) purified B cells (CD19+) at the time of harvest or in (C) whole splenocytes cultured with or without IL4. (B) Actin was used as a loading control, and the white line indicates that intervening lanes have been spliced out.
T131 18586-18779 Sentence denotes (D and E) MTS assay of (D) WT lymphocytes and (E) LMP1 transgenic lymphoma cells cultured with IL4, a neutralizing antibody to IL4, or a rat IgG isotype control at the indicated concentrations.
T132 18780-18834 Sentence denotes Shown are the results from LMP1 transgenic lymphoma 3.
T133 18835-18973 Sentence denotes The results are the mean ± SEM of triplicate samples from a single representative experiment that was repeated twice with similar results.
T134 18976-19244 Sentence denotes Although wild-type lymphocytes cannot be maintained in culture with IL4 supplementation alone (Figure 3A), slight enhancement in MTS activity could be detected if the cells were analyzed at an earlier time point, at 1 d (Figure 4D) versus 3 d (Figure 3A) post-harvest.
T135 19245-19382 Sentence denotes The enhancement of MTS activity induced by IL4 in wild-type lymphocytes could be neutralized by the addition of IL4 antibody (Figure 4D).
T136 19383-19501 Sentence denotes However, neutralizing antibodies to IL4 did not affect the MTS activity of LMP1 transgenic lymphoma cells (Figure 4E).
T137 19502-19635 Sentence denotes In summary, the wild-type and LMP1 transgenic lymphoma cells grew independently of IL4 treatment and did not require Stat6 signaling.
T138 19637-19693 Sentence denotes LMP1 Upregulates IL10 and Constitutively Activates Stat3
T139 19694-19958 Sentence denotes To identify cytokines that may contribute to the increased survival and growth of lymphomas, the expression levels of a panel of cytokines were screened on CD19+ MACS-purified B cells, using an RPA probe set for IL4, IL5, IL10, IL13, IL15, IL9, IL2, IL6, and IFNγ.
T140 19959-20069 Sentence denotes Expression levels were quantified with a phosphorimager and normalized to the ribosomal housekeeping gene L32.
T141 20070-20221 Sentence denotes None of the tested cytokines were detected in wild-type lymphocytes, therefore cytokine:L32 ratios were set to 1 in the mouse B cell lymphoma line 967.
T142 20222-20416 Sentence denotes Transcription of IL10, IL15, and IFNγ were reproducibly detected in LMP1 transgenic lymphocytes and lymphoma cells and was higher than in the B cell lymphoma cell lines 967 and K46μ (Figure 5A).
T143 20417-20697 Sentence denotes There was no significant difference in the expression of IL15 and IFNγ between LMP1 transgenic lymphocytes and lymphoma cells, suggesting that upregulation of IL15 and IFNγ is induced by LMP1 expression in healthy lymphocytes but is not a unique property of malignant lymphocytes.
T144 20698-20886 Sentence denotes Strikingly, IL10, a B lymphocyte stimulatory cytokine, was increased 1.5- to 5-fold in the wild-type and LMP1 transgenic lymphoma cells compared to LMP1 transgenic lymphocytes (Figure 5A).
T145 20887-21026 Sentence denotes Production of IL15 and IFNγ has been associated with induction of cytotoxic effector responses in cells latently infected with EBV [33,34].
T146 21027-21251 Sentence denotes However, transformation and growth properties induced by EBV are associated with the upregulation of IL10 [35–38]; hence, the effects of IL10 upregulation on the growth properties of the lymphoma cells were further examined.
T147 21252-21496 Sentence denotes Immunoblot analysis indicated that LMP1 transgenic lymphocytes and wild-type and LMP1 transgenic lymphoma cells had corresponding increased levels of phosphorylated α and β isoforms of activated Stat3, a target of the IL10 receptor (Figure 5B).
T148 21497-21638 Sentence denotes However, when comparing the same lymphomas, there was no correlation between the levels of IL10 induction and the levels of Stat3 activation.
T149 21639-21757 Sentence denotes This suggests that the activation of Stat3 is not solely induced by IL10 or that Stat3 activation may be constitutive.
T150 21758-21888 Sentence denotes Additionally, there was no correlation between the levels of LMP1 expression and the levels of IL10 induction (Figures 1A and 5A).
T151 21889-22031 Sentence denotes This indicates that the induction of IL10 is a general property associated with enhanced survival and may only be indirectly affected by LMP1.
T152 22032-22205 Sentence denotes Neutralizing antibodies to IL10 did not affect the survival of lymphoma cells as determined by the MTS assay (unpublished data), suggesting constitutive activation of Stat3.
T153 22206-22429 Sentence denotes This was confirmed by immunoblot analysis such that in the presence of anti-IL10 neutralizing antibodies, pStat3 levels remained activated in lymphoma cells isolated from wild-type and LMP1 transgenic lymphomas (Figure 5C).
T154 22430-22587 Sentence denotes Exogenous addition of IL10 enhanced pStat3 activation above constitutive levels, indicating that lymphoma cells are responsive to IL10 treatment (Figure 5C).
T155 22588-22713 Sentence denotes This means that although the lymphoma cells have constitutive Stat3 activation, it may be further enhanced by IL10 induction.
T156 22714-22879 Sentence denotes The neutralizing effect of the anti-IL10 antibody was confirmed by pre-incubation of IL10 with anti-IL10 antibody compared to a rat IgG1 isotype control (Figure 5C).
T157 22880-22957 Sentence denotes Figure 5 LMP1 Upregulates IL10 Expression and Constitutively Activates Stat3
T158 22958-23097 Sentence denotes (A) Relative expression of IL10, IL15, and IFNγ mRNA in WT and LMP1 transgenic B cells (CD19+), as detected with an Rnase protection assay.
T159 23098-23159 Sentence denotes Mouse lymphoma cell lines 967 and K46μ were used as controls.
T160 23160-23282 Sentence denotes Expression levels were quantified with a phosphorimager and values were normalized to the ribosomal housekeeping gene L32.
T161 23283-23357 Sentence denotes The cytokine:L32 ratio was set to 1 in the mouse B cell lymphoma line 967.
T162 23358-23684 Sentence denotes (B and C) Immunoblot analysis of activated pStat3 in purified B cells (CD19+) from WT and LMP1 transgenic mice (B) at the time of harvest, and (C) 4 h after culture with or without IL10, a neutralizing antibody to IL10, or a rat IgG1 isotype control. (C) Shown are the results for WT lymphoma 1 and LMP1 transgenic lymphoma 1.
T163 23685-23748 Sentence denotes Arrows indicate the positions of the α and β isoforms of Stat3.
T164 23749-23785 Sentence denotes Actin was used as a loading control.
T165 23786-23895 Sentence denotes (D) Immunohistochemistry detection of activated nuclear pStat3 in the spleens of WT and LMP1 transgenic mice.
T166 23896-23913 Sentence denotes Scale bar, 20 μm.
T167 23916-24086 Sentence denotes Nuclear translocation of pStat3 is a consequence of activation, and nuclear pStat3 was not detected by immunohistochemistry staining of spleen sections from control mice.
T168 24087-24251 Sentence denotes However, nuclear pStat3 was detectable in LMP1 transgenic mice and wild-type lymphomas and was detected more homogeneously in LMP1 transgenic lymphomas (Figure 5D).
T169 24252-24397 Sentence denotes The constitutive activation of pStat3 and abundant nuclear Stat3 suggests that Stat3 signaling contributes to LMP1-mediated lymphoma development.
T170 24399-24469 Sentence denotes LMP1 Activates Akt Signaling and Deregulates the Rb Cell Cycle Pathway
T171 24470-24552 Sentence denotes LMP1 transformation of rodent fibroblasts requires activation of PI3K and Akt [5].
T172 24553-24676 Sentence denotes Additionally, activated pAkt is frequently detected in NPC and the neoplastic Reed-Sternberg cells of classical HD [39,40].
T173 24677-24848 Sentence denotes To determine if Akt signaling is activated in LMP1 transgenic mice, pAkt and several of its targets were assessed by immunoblotting of splenic CD19+ MACS-purified B cells.
T174 24849-25058 Sentence denotes LMP1 transgenic B cells had increased levels of pAkt compared to wild-type lymphocytes; however, progression to lymphoma in both LMP1-positive and -negative lymphoma cells did not further increase pAkt levels.
T175 25059-25287 Sentence denotes The Akt target glycogen synthase kinase 3 (GSK3) is inactivated by phosphorylation; however, increased phosphorylated GSK3 was not detected in the transgenic lymphocytes and was almost absent in the lymphoma samples (Figure 6A).
T176 25288-25408 Sentence denotes This finding indicates that GSK3 is not a target of activated Akt in the LMP1 transgenic lymphocytes and lymphoma cells.
T177 25409-25520 Sentence denotes Similarly, activation of Akt without phosphorylation of GSK3 has been previously shown in EBV-positive HD [40].
T178 25521-25625 Sentence denotes In contrast, the wild-type lymphocytes lacked activated Akt but did have detectable phosphorylated GSK3.
T179 25626-25712 Sentence denotes This further suggests that additional pathways are involved in the regulation of GSK3.
T180 25713-25793 Sentence denotes Figure 6 LMP1 Activates Akt Signaling and Deregulates the Rb Cell Cycle Pathway
T181 25794-26058 Sentence denotes (A and B) Immunoblot analysis of purified B cells (CD19+) from the spleens of WT and LMP1 transgenic mice for Akt signaling, probing for (A) activated pAkt and downstream targets, including inactivated pGSK3α/β, and (B) activated p-mTOR, and total levels of FoxO1.
T182 26059-26117 Sentence denotes Arrows indicate the positions of α and β isoforms of GSK3.
T183 26118-26188 Sentence denotes The white line indicates that intervening lanes have been spliced out.
T184 26189-26342 Sentence denotes (C) Immunoblot analysis for cell cycle proteins regulating the Rb pathway, probing for activated pRb, and total levels of Cdk2 and the Cdk inhibitor p27.
T185 26343-26379 Sentence denotes Actin was used as a loading control.
T186 26382-26468 Sentence denotes To identify other potential Akt targets, immunoblot analysis for p-mTOR was performed.
T187 26469-26690 Sentence denotes Activated p-mTOR was not increased in LMP1 transgenic lymphocytes or lymphoma cells, indicating that this pathway is not affected by LMP1-induced Akt activation and does not contribute to lymphoma development (Figure 6B).
T188 26691-26892 Sentence denotes Akt is also known to phosphorylate and induce the degradation of the pro-apoptotic Forkhead family of transcription factors, leading to cell cycle progression and survival in some human tumors [41,42].
T189 26893-27020 Sentence denotes Immunoblot analysis of splenic B cells did not consistently detect p-FoxO1 levels, a signal that targets FoxO1 for degradation.
T190 27021-27097 Sentence denotes Hence, degradation of FoxO1 was assessed by detection of total FoxO1 levels.
T191 27098-27346 Sentence denotes Immunoblot analysis indicated that total FoxO1 levels were greatly decreased in wild-type and LMP1 transgenic lymphomas (Figure 6B), suggesting that inhibition of the Forkhead signaling pathway is an important target of Akt in lymphoma development.
T192 27347-27577 Sentence denotes However, considering that Akt activation did not induce FoxO1 degradation in LMP1 transgenic B cells, Akt may not be the sole regulator of FoxO1, and it may be that progression to lymphoma requires modulation of multiple pathways.
T193 27578-27690 Sentence denotes The Forkhead family of transcription factors is known to induce the expression of the Cdk inhibitor p27 [43,44].
T194 27691-27868 Sentence denotes LMP1-transformed rodent fibroblasts have decreased expression of p27, upregulation of Cdk2, and subsequent phosphorylation and inactivation of the tumor suppressor gene Rb [45].
T195 27869-28060 Sentence denotes To investigate whether LMP1 affected cell cycle regulation through the Rb pathway in B cells, immunoblot analyses for pRb, Cdk2, and p27 were performed on splenic CD19+ MACS-purified B cells.
T196 28061-28219 Sentence denotes LMP1 transgenic B cells had enhanced levels of pRb with concomitant stabilization of total Rb levels and Cdk2 compared to wild-type B lymphocytes (Figure 6C).
T197 28220-28405 Sentence denotes Progression to lymphoma in both wild-type and LMP1 transgenic lymphoma cells led to increased levels of Rb, correspondingly high levels of Cdk2, and decreased levels of p27 (Figure 6C).
T198 28406-28569 Sentence denotes These data indicate that the Rb pathway is deregulated in LMP1 transgenic lymphocytes and that lymphoma cells are distinguished by loss of FoxO1 and decreased p27.
T199 28571-28662 Sentence denotes LMP1 Promotes Tumor Growth and Survival through Activation of Akt, NFκB, and Stat3 Pathways
T200 28663-28952 Sentence denotes To explore which pathways were required for the enhanced growth and survival of LMP1-induced lymphomas, splenocytes from wild-type and LMP1 transgenic mice were cultured in the presence of inhibitors for Akt, NFκB, Stat3, mTOR, or MAPK and assayed for growth and survival by the MTS assay.
T201 28953-29067 Sentence denotes As previously shown, wild-type lymphocytes were not viable in culture and could not be tested with the inhibitors.
T202 29068-29306 Sentence denotes However, the enhanced viability of LMP1 transgenic lymphocytes was effectively blocked by treatment with triciribine, BAY11–7085, cucurbitacin I, and slightly with SB203580, but not by treatment with rapamycin, U0126, or AG490 (Figure 7).
T203 29307-29450 Sentence denotes Triciribine inhibits the activation of Akt and at 20 μM has been shown to induce growth arrest in cancer cells with aberrant Akt activity [46].
T204 29451-29702 Sentence denotes The effects of triciribine on cell growth of the transgenic lymphocytes and lymphomas were apparent as low as 1 μM, suggesting that activation of Akt is required for the survival and growth of LMP1 transgenic lymphocytes and lymphoma cells (Figure 7).
T205 29703-29825 Sentence denotes The effects of the inhibitors were assessed by identifying phosphorylated Akt, Stat3, and total levels of IκBα (Figure 8).
T206 29826-29953 Sentence denotes Treatment with triciribine effectively blocked phosphorylation of Akt, and phosphorylated Akt was no longer detected past 5 μM.
T207 29954-30012 Sentence denotes Phosphorylated Stat3 and IκBα were still present at 25 μM.
T208 30013-30190 Sentence denotes These findings suggest that triciribine specifically targets Akt and that Akt activation is required for the enhanced viability of the transgenic lymphocytes and lymphoma cells.
T209 30191-30290 Sentence denotes Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells
T210 30291-30415 Sentence denotes MTS assay of splenocytes from (A and B) WT or (C and D) LMP1 transgenic lymphomas and (E and F) LMP1 transgenic lymphoctyes.
T211 30416-30623 Sentence denotes Splenocytes were cultured with or without inhibitors of NFκB (BAY11), mTOR (rapamycin), Akt (triciribine), MEK1/2 (U0126), p38 (SB202190), or Stat3 (cucurbitacin I and AG490) at the indicated concentrations.
T212 30624-30677 Sentence denotes The results are the mean ± SEM of triplicate samples.
T213 30678-30826 Sentence denotes Shown are the results for (A and B) WT lymphoma 1, (C and D) LMP1 transgenic lymphoma 2, and (E and F) one out of two LMP1 transgenic mice analyzed.
T214 30827-30911 Sentence denotes This analysis was repeated with LMP1 transgenic lymphoma 4 yielding similar results.
T215 30912-31024 Sentence denotes Figure 8 Analysis of Akt, NFκB, and Stat3 Pathways in Contribution to the Growth and Survival of Lymphoma Cells
T216 31025-31311 Sentence denotes (A–D) Immunoblot analysis of wild-type and LMP1 transgenic lymphomas for Akt, NFκB, and Stat3 signaling after treatment with (A) an Akt inhibitor, triciribine, (B) an NFκB inhibitor, BAY11–7085, and the Stat3 inhibitors (C) cucurbitacin I and (D) AG490, at the indicated concentrations.
T217 31312-31371 Sentence denotes Arrows indicate the positions of α and β isoforms of Stat3.
T218 31372-31408 Sentence denotes Actin was used as a loading control.
T219 31411-31506 Sentence denotes Inhibition of NFκB signaling rapidly induces cell death of EBV-transformed lymphocytes [17,18].
T220 31507-31726 Sentence denotes BAY11–7085, an inhibitor of NFκB signaling, also greatly decreased the viability of the LMP1 transgenic lymphocytes and lymphoma cells at doses as low as 1 μM, and at 5 μM the cells were completely nonviable (Figure 7).
T221 31727-31774 Sentence denotes This is well within the reported IC50 of 10 μM.
T222 31775-31907 Sentence denotes Phosphorylated Akt, Stat3, and total IκBα were still present up to treatment with 15 μM and then were no longer detected (Figure 8).
T223 31908-32084 Sentence denotes This finding suggests that inhibition of NFκB can induce cell death in LMP1 transgenic lymphocytes and lymphoma cells without significant effects on activation of Akt or Stat3.
T224 32085-32178 Sentence denotes Cucurbitacin I inhibits activation of Stat3 by suppressing the activation of its kinase JAK2.
T225 32179-32282 Sentence denotes It has been shown to selectively inhibit the growth of tumors with constitutively activated Stat3 [47].
T226 32283-32485 Sentence denotes Similarly, LMP1 transgenic lymphocytes and lymphoma cells were susceptible to cucurbitacin I treatment starting at 0.1 μM, a dose that corresponds closely to the reported IC50 of 500 nM (Figure 7) [47].
T227 32486-32674 Sentence denotes Phosphorylated Akt, Stat3, and total IκBα were not detectable past 1 μM and at higher doses all protein levels were greatly decreased, indicative of the total loss of viability (Figure 8).
T228 32675-32838 Sentence denotes A second reported inhibitor of Stat3, AG490, had no effect on growth (Figure 7), but activation of Akt, Stat3, or levels of IκBα were also not affected (Figure 8).
T229 32839-33047 Sentence denotes These findings suggest that inhibition of Stat3 can induce cell death in LMP1 transgenic lymphocytes and lymphoma cells, but Stat3 inhibition also has considerable crossover effects on Akt and NFκB signaling.
T230 33048-33283 Sentence denotes LMP1 has also been shown to activate JNK and p38 MAPK pathways [13,48], and LMP1 transgenic lymphocytes were mildly susceptible to growth inhibition by SB202190, an inhibitor of p38 MAPK, but not U0126, an inhibitor of MEK1/2 activity.
T231 33284-33548 Sentence denotes However, effects of SB202190 were only apparent at high doses (>10 μM), much higher than the reported IC50 of 0.35 μM, suggesting that p38 MAPK does not significantly contribute to the enhanced viability in LMP1 transgenic lymphocytes or lymphoma cells (Figure 7).
T232 33549-34122 Sentence denotes Interestingly, both wild-type and LMP1 transgenic lymphomas were similarly susceptible to triciribine, BAY11–7085, and cucurbitacin I treatments, but not SB202190, AG490, or U0126 treatment, suggesting that activation of Akt, NFκB, and Stat3 but not MAPK pathways are characteristics associated with malignant transformation (Figure 7). rapamycin, an inhibitor of mTOR, did not affect the viability of the transgenic lymphocytes or lymphoma cells, confirming that mTOR is not targeted by Akt activation in LMP1 transgenic lymphocytes or malignant lymphoma cells (Figure 7).
T233 34124-34134 Sentence denotes Discussion
T234 34135-34223 Sentence denotes This study defines the oncogenic properties of LMP1 in promoting B cell lymphomagenesis.
T235 34224-34450 Sentence denotes LMP1 transgenic mice have a higher incidence of lymphoma [26] and the progression to lymphoma correlates with higher expression levels of LMP1 (Figure 1A and 1B), suggesting that LMP1 is directly involved in tumor development.
T236 34451-34574 Sentence denotes Table 1 summarizes the biological and molecular properties that were identified in wild-type and LMP1 transgenic lymphomas.
T237 34575-34838 Sentence denotes Although many of the molecular properties studied were similar between wild-type and LMP1 transgenic lymphomas, there were distinguishing biological properties, namely the ability of LMP1 transgenic lymphomas to induce higher levels of survival and proliferation.
T238 34839-35069 Sentence denotes Interestingly, although LMP1 transgenic mice develop lymphomas in the same B-1a cell type as spontaneous wild-type lymphomas (Figure 2), some signaling effects induced by LMP1 may explain the enhanced promotion to lymphomagenesis.
T239 35070-35310 Sentence denotes Since CD40-deficient mice have decreased numbers of IgMhighIgDlow cells, a phenotype associated with B-1, marginal zone, and memory B cells, the mimicry of CD40 signaling by LMP1 could possibly contribute to the expansion of B-1 cells [20].
T240 35311-35500 Sentence denotes It is noteworthy that expression of LMP1 in transgenic mice has been shown to inhibit the formation of GCs [23,49], preventing typical B-2 cells from antigen-driven selection and expansion.
T241 35501-35604 Sentence denotes The lack of GC reactions may contribute to the bias of LMP1 transgenic mice towards B-1 cell lymphomas.
T242 35605-35722 Sentence denotes Interestingly, LMP2 signaling also favors development of B-1 cells, but this occurs in the absence of transformation.
T243 35723-35867 Sentence denotes These results suggest that the mimicry of B cell receptor signaling by LMP2 promotes B-1 cell differentiation but not transformation [24,50,51].
T244 35868-36005 Sentence denotes This promotion of B-1 differentiation may account for the ability of LMP2 to exacerbate autoimmunity and bypass anergy induction [52,53].
T245 36006-36248 Sentence denotes In contrast, the preponderance of tumors of B-1a origin does not reflect effects of LMP1 signaling on B cell differentiation, as splenic B cells from healthy LMP1 transgenic mice contain similar numbers of B-1 and B-2 cells as wild-type mice.
T246 36249-36380 Sentence denotes In support of this lack of effect, the differentiation of B-1 versus B-2 cells is thought to be independent of CD40 signaling [54].
T247 36381-36571 Sentence denotes B-1 cells constitute the predominant lymphocyte population in the peritoneal and pleuropericardial cavities, while B-2 cells are mainly found in the spleen, lymph node, and peripheral blood.
T248 36572-36722 Sentence denotes B-1 cells produce the main source of IgM and IgA antibodies in serum, which are involved in T cell–independent responses to common microbial antigens.
T249 36723-36840 Sentence denotes Importantly, B-1 cells have the unique capacity to self replenish and are also predisposed to transformation [28,29].
T250 36841-37019 Sentence denotes Clonal expansion of B-1 cells can be detected in aging mice above 18 mo of age, and B-1 cells are thought to be the murine progenitor of B cell chronic lymphocytic leukemia [30].
T251 37020-37194 Sentence denotes The data presented in this study indicate that although LMP1 is expressed in all B lymphocytes in the transgenic mice, malignancy develops in this specific subset of B cells.
T252 37195-37316 Sentence denotes The elevated expression of LMP1 in B-1a cells and the activation of specific pathways apparently induce malignant growth.
T253 37317-37429 Sentence denotes These same pathways can also become sporadically activated in aged mice and also result in lymphoma development.
T254 37430-37609 Sentence denotes This is similar to EBV-associated cancers in vivo, where pathways that are activated by LMP1 are also activated in the less prevalent EBV-negative forms of the cancers [40,55–58].
T255 37610-37798 Sentence denotes Thus, the contribution of EBV and LMP1 to tumor development is apparently the continuous activation of pathways that can also be sporadically activated and contribute to tumor development.
T256 37799-37982 Sentence denotes The lymphomas were marked by the upregulation of IL10, constitutive activation of Stat3 signaling, and a requirement for activation of Akt, NFκB, and Stat3 pathways (Figures 5 and 7).
T257 37983-38180 Sentence denotes Induction of IL10 is associated with the transformation of B-1 lymphomas in mice [59,60] and is frequently associated with EBV-positive B cell malignancies acting as a B cell growth factor [35–38].
T258 38181-38282 Sentence denotes In addition, LMP1 has been shown to stimulate IL10 expression in Burkitt lymphoma cell lines [61,62].
T259 38283-38489 Sentence denotes This suggests that although Stat3 is constitutively activated in the lymphoma cells, the induction of IL10 may further enhance Stat3 activation or may contribute to other IL10-responsive signaling pathways.
T260 38490-38703 Sentence denotes LMP1 activates both the canonical and non-canonical pathways of NFκB signaling [14,63–65], and inhibition of NFκB blocked the survival of LMP1 transgenic lymphocytes and LMP1-positive and -negative lymphoma cells.
T261 38704-38909 Sentence denotes NFκB and PI3K signaling are crucial for CD40-induced proliferation, and mice deficient for cRel or the p85 regulatory subunit of PI3K are unresponsive to mitogenic stimuli, including CD40 ligation [66–68].
T262 38910-39101 Sentence denotes We have previously shown that cRel is specifically activated in both wild-type and LMP1 transgenic lymphomas, suggesting that activation of cRel is associated with B cell transformation [27].
T263 39102-39285 Sentence denotes Our observations suggest that similar to CD40-induced proliferation, LMP1 induces proliferation through PI3K-mediated activation of Akt and activation of NFκB components such as cRel.
T264 39286-39508 Sentence denotes CD40 also induces downregulation of the cell cycle inhibitor p27 through a PI3K-dependent manner, and the LMP1 lymphoma cells also had decreased levels of p27 with phosphorylation of Rb and increased Cdk2 (Figure 6C) [66].
T265 39509-39676 Sentence denotes Although LMP1 has been shown to deregulate the Rb pathway in epithelial cells [69], to our knowledge this is the first demonstration of this property in B lymphocytes.
T266 39677-39808 Sentence denotes The requirement for Akt activation was confirmed by the striking inhibition of lymphoma viability by triciribine, an Akt inhibitor.
T267 39809-39928 Sentence denotes However, the activated pAkt did not lead to phosphorylation and inactivation of the downstream target GSK3 (Figure 6A).
T268 39929-39998 Sentence denotes This effect has also been described in EBV-positive HD biopsies [40].
T269 39999-40178 Sentence denotes In contrast, rapamycin, U0126, and SB202190 did not affect the survival of LMP1 transgenic lymphocytes or the wild-type and LMP1 transgenic lymphoma cells (Figure 7A, 7C, and 7E).
T270 40179-40273 Sentence denotes This lack of effect by rapamycin confirmed the absence of activated p-mTOR levels (Figure 6B).
T271 40274-40356 Sentence denotes These findings suggest that other Akt targets contribute to malignant progression.
T272 40357-40432 Sentence denotes One key target is likely the inhibition of the Fox01 transcription factors.
T273 40433-40609 Sentence denotes Repression of the pro-apoptotic transcription factor FoxO1 in a PI3K-dependent manner can inhibit expression of bcl6, a transcription factor necessary for GC formation [49,70].
T274 40610-40720 Sentence denotes It has been shown that overstimulation of CD40 signaling with agonistic antibodies inhibits GC formation [71].
T275 40721-40830 Sentence denotes Similarly, due to mimicry of CD40 signaling, transgenic LMP1 mice are also defective in GC formation [23,49].
T276 40831-40924 Sentence denotes The constitutive signaling by LMP1 likely blocks GC formation through downregulation of bcl6.
T277 40925-41057 Sentence denotes Interestingly, clinical studies indicate that expression of LMP1 and bcl6 are mutually exclusive in non-HD and classical HD [72,73].
T278 41058-41127 Sentence denotes Thus, the LMP1 transgenic lymphomas mirror aspects of EBV-induced HD.
T279 41128-41418 Sentence denotes Although the activation of Akt and the lack of Fox01 in the lymphoma cells suggest that LMP1 affects bcl6 and GC formation through this pathway, regulation of other Forkhead targets involved in cell cycle progression, such as p27 and CyclinD2, likely contribute to malignant transformation.
T280 41419-41519 Sentence denotes Indeed, loss of FoxO1 expression in lymphoma cells correlated with a loss of p27 (Figure 6B and 6C).
T281 41520-41625 Sentence denotes CyclinD2 has also been shown to be upregulated by LMP1 through release of FoxO1-mediated repression [70].
T282 41626-41785 Sentence denotes In summary, in this transgenic model of lymphomagenesis, LMP1 promotes malignancy in B-1a cells, a population that is predisposed to clonal expansion with age.
T283 41786-42012 Sentence denotes The malignant lymphocytes were distinguished by constitutively active Stat3 signaling, decreased p27, and activated Akt and NFκB pathways, properties that are associated with promoting the growth and survival of B lymphocytes.
T284 42013-42181 Sentence denotes Importantly, Akt, NFκB, and Stat3 pathways were critically required for the growth and survival of malignant lymphocytes as well as healthy LMP1 transgenic lymphocytes.
T285 42182-42351 Sentence denotes The growth of EBV-transformed lymphocytes also requires activation of NFκB, and these studies provide insight into how LMP1 contributes to EBV-associated transformation.
T286 42352-42520 Sentence denotes The transgenic lymphomas mirror multiple aspects of EBV-induced tumors and suggest that in vivo these properties of LMP1 are major factors in the development of cancer.
T287 42522-42543 Sentence denotes Materials and Methods
T288 42545-42561 Sentence denotes Transgenic mice.
T289 42562-42728 Sentence denotes Generation of LMP1 mice under the Ig heavy chain promoter and enhancer have been described previously and were maintained as heterozygotes on a Balbc background [26].
T290 42729-42829 Sentence denotes LMP1 mice were genotyped by Southern blot and PCR analysis of tail DNA as described previously [26].
T291 42830-43005 Sentence denotes Spleen and liver sections were fixed in 4% paraformaldehyde and embedded in paraffin, and 5-μm sections were stained with hematoxylin and eosin for histopathological analysis.
T292 43006-43152 Sentence denotes Lymphomas were passaged by intraperitoneal injection of 1 × 108 splenocytes into SCID mice and sacrificed upon development of an extended abdomen.
T293 43153-43317 Sentence denotes Animals were housed in the Association for Assessment and Accreditation for Animal Care–approved animal facility at the University of North Carolina at Chapel Hill.
T294 43318-43397 Sentence denotes All protocols were approved by the Institutional Animal Care and Use Committee.
T295 43399-43431 Sentence denotes Isolation and growth of B cells.
T296 43432-43567 Sentence denotes Splenocytes were prepared by homogenizing spleen tissue with two frosted slides and debris was filtered through a 100-μm cell strainer.
T297 43568-43698 Sentence denotes Erythrocytes were lysed using 0.8% ammonium chloride solution (StemCell Technologies) for 10 min on ice and washed twice with PBS.
T298 43699-43928 Sentence denotes B cells were isolated using CD19-MACS beads according to the manufacturer's instructions (Miltenyi Biotec) and grown in Iscove's medium supplemented with heat-inactivated 10% fetal bovine serum and antibiotic/antimycotic (GIBCO).
T299 43929-44098 Sentence denotes Splenocytes isolated from SCID-passaged lymphomas consisted of 80%–90% B cells as determined by flow cytometry, and were hence not further purified with CD19-MACS beads.
T300 44099-44334 Sentence denotes Splenocytes were seeded at 1.25 × 106 cells/ml and where applicable, recombinant mouse IL4 was added at 100 ng/ml, recombinant mouse IL10 at 10 ng/ml, and rat IgG1 anti-mouse IL10 and rat IgG1 isotype control at 10 μg/ml (R&D Systems).
T301 44335-44432 Sentence denotes For BrdU incorporation assays, splenocytes were pulsed for 24 h with 10 μM BrdU 1 d post-harvest.
T302 44434-44444 Sentence denotes MTS assay.
T303 44445-44731 Sentence denotes The 3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) cell cytotoxicity/proliferation assays were performed using the CellTiter 96 aqueous one-solution cell proliferation assay (Promega), according to manufacturer's instructions.
T304 44732-44827 Sentence denotes For IL4 studies, splenocytes were cultured for 3 d in the presence or absence of 100 ng/ml IL4.
T305 44828-44929 Sentence denotes Cells were seeded on day 3 in triplicate in a 96-well plate at 2.5 × 106 cells/ml at 100 μl per well.
T306 44930-45038 Sentence denotes MTS reagent was added for 4 h and absorbance was read at 540 nm; values plotted were subtracted from blanks.
T307 45039-45281 Sentence denotes For neutralization assays, splenocytes were seeded at 5 × 106 cells/ml at 100 μl per well on day of harvest and IL4, rat IgG1 anti-mouse IL4, or rat IgG1 isotype control (R&D Systems) were added at the concentrations indicated in the figures.
T308 45282-45345 Sentence denotes Cultures were pulsed for 4 h with MTS reagent 1 d post-seeding.
T309 45346-45524 Sentence denotes For inhibitor studies, splenocytes were seeded at 1 × 107 cells/ml at 100 μl per well on day of harvest, and inhibitors were added at the concentrations indicated in the figures.
T310 45525-45648 Sentence denotes The inhibitors BAY11–7085, rapamycin, triciribine, U0126, SB202190, and cucurbitacin I were purchased from EMD Biosciences.
T311 45649-45787 Sentence denotes For non-malignant splenocyte cultures, B cell activation was induced with 10 μg/ml of goat F(ab') anti-mouse IgM (Jackson ImmunoResearch).
T312 45788-45851 Sentence denotes Cultures were pulsed for 4 h with MTS reagent 1 d post-seeding.
T313 45853-45874 Sentence denotes Immunohistochemistry.
T314 45875-45999 Sentence denotes Paraffin-embedded spleen sections were deparaffinized in Histoclear (National Diagnostics) and rehydrated in graded ethanol.
T315 46000-46130 Sentence denotes Sections were antigen retrieved by microwaving in citrate buffer (pH 6.0) for 15 min (LMP1 staining) and 10 min (pStat3 staining).
T316 46131-46270 Sentence denotes For LMP1 staining, sections were blocked with 1% BSA and 0.1% cold fish skin gelatin followed with streptavidin/biotin block (Vector Labs).
T317 46271-46582 Sentence denotes Rat IgG anti-LMP1 (clones 8G3 and 1G6, Ascenion) were used at 1:10 dilution from tissue culture supernatants, followed with 8 μg/ml biotinylated mouse F(ab') anti-rat IgG (H+L) pre-adsorbed to mouse serum (Jackson ImmunoResearch) and 2 μg/ml streptavidin-alkaline phosphatase conjugate (Jackson ImmunoResearch).
T318 46583-46665 Sentence denotes Stains were developed with BCIP/NBT and counterstained in Nuclear Fast Red (Dako).
T319 46666-46818 Sentence denotes Phospho-Stat3 was detected with 4 μg/ml of pStat3 antibody (Tyr705, Cell Signaling) and detected with anti-rabbit Poly-HRP IHC detection kit (Chemicon).
T320 46820-46835 Sentence denotes Flow cytometry.
T321 46836-47000 Sentence denotes One million splenocytes were stained with the appropriate primary antibody unconjugated or conjugated to FITC, PE, or APC diluted in stain buffer (PBS with 3% FBS).
T322 47001-47103 Sentence denotes For BrdU detection, the FITC-BrdU flow kit was used as instructed by the manufacturer (BD Bioscience).
T323 47104-47275 Sentence denotes Briefly, cells were exposed to EMA (Molecular Probes) for exclusion of dead cells, stained for surface antigens, fixed in paraformaldehyde, and permeabilized with saponin.
T324 47276-47383 Sentence denotes To expose BrdU epitopes, cells were treated with Dnase and stained with FITC-conjugated anti-BrdU antibody.
T325 47384-47475 Sentence denotes Flow cytometry was performed on FACScalibur using the CellQuest program (Becton Dickinson).
T326 47476-47541 Sentence denotes Further analysis was conducted on the Summit v4.2 program (Dako).
T327 47543-47566 Sentence denotes Rnase protection assay.
T328 47567-47738 Sentence denotes Total RNA was isolated from CD19+ MACS-purified B cells using the Rneasy midi purification kit with Dnase treatment, according to the manufacturer's instructions (Qiagen).
T329 47739-47896 Sentence denotes The mCK-1 probe template set (BD Biosciences) was labeled using the In Vitro Transcription Kit according to the manufacturer's instructions (BD Biosciences).
T330 47897-48054 Sentence denotes Briefly, 50 ng of mCK-1 probe set was labeled with [α-32P]UTP using T7 RNA polymerase and purified using Sephadex G-50 columns (NucAway Spin column, Ambion).
T331 48055-48224 Sentence denotes The labeled probe was quantitated using a scintillation counter, and 6 × 105 cherenkov cpm was used to hybridize to 4 μg of total RNA using the RPA kit (BD Biosciences).
T332 48225-48291 Sentence denotes Samples were denatured at 90 °C and hybridized at 56 °C overnight.
T333 48292-48394 Sentence denotes Single-stranded RNA was digested with a mixture of Rnase A and T1, and precipitated using isopropanol.
T334 48395-48526 Sentence denotes Protected probes were resolved on a denaturing 4.75% acrylamide gel, dried, and imaged using a phosphorImager (Molecular Dynamics).
T335 48527-48609 Sentence denotes Densitometry was performed using the ImageQuant TL v2005 software (GE Healthcare).
T336 48611-48649 Sentence denotes PCR analysis of κ chain rearrangement.
T337 48650-48743 Sentence denotes DNA was isolated from splenocytes using the Dneasy Tissue Kit (Qiagen), with Rnase treatment.
T338 48744-48899 Sentence denotes PCR reactions contained 100 ng of genomic DNA, 0.2 μM each primer, 0.2 mM dNTPs, and 2.5 U Taq DNA polymerase (NEB) performed in 1X ThermoPol buffer (NEB).
T339 48900-48975 Sentence denotes Primers used were Vκcon and Jκ5–1° and have been described previously [74].
T340 48976-49118 Sentence denotes PCR conditions were 94 °C for 2 min, 40 cycles of 94 °C for 30 s, 63 °C for 90 s, and 72 °C for 1 min, followed by 1 cycle of 72 °C for 5 min.
T341 49120-49140 Sentence denotes Immunoblot analysis.
T342 49141-49444 Sentence denotes Whole cell lysates were prepared in radioimmunoprecipitation assay (RIPA) buffer (20 mM Tris-HCl [pH 7.5], 150 mM NaCl, 1 mM EDTA, 1% NP-40, 0.1% SDS, 0.1% sodium deoxycholate) supplemented with 2 mM phenylmethylsulfonyl fluoride, 1 mM Na3VO4, and 1:100 protease/phosphatase inhibitor cocktails (Sigma).
T343 49445-49566 Sentence denotes Crude lysates were centrifuged at 13,000 rpm for 10 min at 4 °C and the supernatants were collected for further analysis.
T344 49567-49647 Sentence denotes Protein concentrations were determined with the Bio-Rad DC protein assay system.
T345 49648-49840 Sentence denotes Lysates were boiled in the presence of 2.5% β-mecaptoethanol, separated by denaturing SDS-PAGE, and transferred to 0.45-μm Optitran membranes (Schleicher & Schuell) in a Bio-Rad transfer unit.
T346 49841-50063 Sentence denotes Membranes were immunoblotted with the appropriate primary antibody followed by horseradish peroxidase–tagged secondary antibodies (Amersham Biosciences and Dako) and detected with the SuperSignal West Pico System (Pierce).
T347 50065-50076 Sentence denotes Antibodies.
T348 50077-50371 Sentence denotes FITC-conjugated goat anti-mouse IgM, rat IgG2aκ anti-mouse IgD (clone 11–26), rat IgG1κ anti-mouse kappa (clone 187.1), rat IgG2bκ anti-mouse lambda (clone JC5–1); PE-conjugated goat anti-mouse IgG; un-conjugated goat anti-mouse kappa and anti-mouse lambda were purchased from Southern Biotech.
T349 50372-50581 Sentence denotes APC-conjugated rat IgG2aκ anti-mouse CD19 (clone 6D5), PE-conjugated mouse IgG2aκ anti-LMP1 (clone S12), un-conjugated mouse IgG2a anti-Rb (clone 2), and anti-Cdk2 (clone 55) were purchased from BD Bioscience.
T350 50582-50668 Sentence denotes PE-conjugated rat IgG2aκ anti-mouse CD5 (clone 53–7.3) was purchased from eBioscience.
T351 50669-50744 Sentence denotes Rat anti-LMP1 (clones 8G3, 1G6, 7E10, and 7G8) was purchased from Ascenion.
T352 50745-50945 Sentence denotes Rabbit anti-pAkt (Ser473), anti-pGSK3α/β (Ser21/9), anti-pStat3 (Tyr705), anti-pStat6 (Tyr641), anti-pmTOR (Ser2448), anti-Stat6, anti-Akt, anti-FoxO1, and anti-p27 were purchased from Cell Signaling.
T353 50946-51065 Sentence denotes Rabbit anti-Stat3 (H-190), anti-IκBα (C-21), and goat anti-β actin (I-19) were purchased from Santa Cruz Biotechnology.
T354 51066-51129 Sentence denotes Mouse IgG1κ anti-GSK3 was purchased from Upstate Biotechnology.
T355 51130-51190 Sentence denotes Rabbit anti-pRb (Thr373) was purchased from EMD Biosciences.
T356 51192-51214 Sentence denotes Supporting Information
T357 51215-51277 Sentence denotes Figure S1 Lymphomas Are Clonal by κ Light Chain Rearrangement
T358 51278-51341 Sentence denotes PCR analysis of total spleen genomic DNA for the mouse κ locus.
T359 51342-51432 Sentence denotes Primers were designed to amplify all V-J rearrangements, including VJ1, VJ2, VJ4, and VJ5.
T360 51433-51547 Sentence denotes Specific PCR products for the four rearrangements corresponding to the calculated sizes are indicated with arrows.
T361 51548-51602 Sentence denotes Bands of other sizes are due to non-specific products.
T362 51603-51733 Sentence denotes If a tumor was present in the background of normal spleen cells, a single band appears brighter than all the other specific bands.
T363 51734-51852 Sentence denotes Wild-type and LMP1 transgenic lymphocytes are positive for all four V-J rearrangements and serve as positive controls.
T364 51853-51968 Sentence denotes Clonality is determined by the appearance of a predominant band at the correct size for a single V-J rearrangement.
T365 51969-52018 Sentence denotes (739 KB PDF) Click here for additional data file.
T366 52020-52037 Sentence denotes Accession Numbers
T367 52038-52146 Sentence denotes The GenBank (http://www.ncbi.nlm.nih.gov/Genbank/) accession number for the EBV genome sequence is AJ507799.
T368 52147-52185 Sentence denotes The gene identifier for LMP1 is BNLF1.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T2980 2925-2929 Protein denotes CD40
T2981 2997-3001 Protein denotes CD40
T2982 3002-3011 Binding denotes interacts
T2983 3017-3028 Protein denotes CD40 ligand
T2984 3029-3038 Gene_expression denotes expressed
T2985 3109-3113 Protein denotes LMP1
T2986 3171-3186 Binding denotes oligomerization
T2987 3188-3192 Protein denotes LMP1
T2988 3197-3201 Protein denotes CD40
T2989 3202-3210 Binding denotes interact
T2990 3202-3210 Binding denotes interact
T2991 3225-3246 Protein denotes tumor necrosis factor
T2992 3314-3319 Protein denotes c-Jun
T2993 3542-3546 Protein denotes LMP1
T2994 3599-3602 Protein denotes Akt
T2995 3654-3658 Protein denotes LMP1
T2996 3760-3764 Protein denotes CD40
T2997 3765-3773 Binding denotes ligation
T2998 3794-3797 Protein denotes IL4
T2999 3818-3822 Protein denotes CD40
T3000 3896-3905 Negative_regulation denotes deficient
T3001 3896-3905 Negative_regulation denotes deficient
T3002 3910-3914 Protein denotes CD40
T3003 3918-3923 Protein denotes CD40L
T3004 4006-4023 Entity denotes membrane proximal
T3005 4028-4054 Entity denotes distal cytoplasmic regions
T3006 4058-4062 Protein denotes CD40
T3007 4068-4072 Binding denotes bind
T3008 4068-4072 Binding denotes bind
T3009 4068-4072 Binding denotes bind
T3010 4068-4072 Binding denotes bind
T3011 4073-4078 Protein denotes TRAF6
T3012 4083-4089 Protein denotes TRAFs2
T3013 4090-4091 Protein denotes 3
T3014 4092-4093 Protein denotes 5
T3015 4287-4291 Protein denotes LMP1
T3016 4296-4302 Negative_regulation denotes rescue
T3017 4303-4307 Protein denotes CD40
T3018 4308-4317 Negative_regulation denotes deficient
T3019 4392-4396 Protein denotes LMP1
T3020 4397-4405 Binding denotes recruits
T3021 4397-4405 Binding denotes recruits
T3022 4397-4405 Binding denotes recruits
T3023 4397-4405 Binding denotes recruits
T3024 4397-4405 Binding denotes recruits
T3025 4430-4437 Protein denotes TRAFs 1
T3026 4438-4439 Protein denotes 2
T3027 4440-4441 Protein denotes 3
T3028 4442-4443 Protein denotes 5
T3029 4448-4453 Protein denotes TRAF6
T3030 4467-4498 Entity denotes C-terminal activation regions 1
T3031 4503-4512 Entity denotes 2 domains
T3032 4537-4541 Protein denotes LMP1
T3033 4700-4704 Protein denotes LMP1
T3034 4736-4745 Gene_expression denotes expressed
T3035 4746-4763 Positive_regulation denotes under the control
T3036 4821-4825 Protein denotes LMP1
T3037 4851-4858 Gene_expression denotes express
T3038 4859-4863 Protein denotes LMP1
T3039 5023-5027 Protein denotes LMP1
T3040 5071-5075 Protein denotes LMP1
T3041 5120-5129 Positive_regulation denotes activated
T3042 5130-5133 Protein denotes Akt
T3043 5169-5179 Positive_regulation denotes activation
T3044 5206-5210 Protein denotes cRel
T3045 5236-5240 Protein denotes LMP1
T3046 5684-5688 Protein denotes LMP1
T3047 5792-5795 Protein denotes IL4
T3048 5815-5819 Protein denotes LMP1
T3049 5878-5881 Protein denotes IL4
T3050 5953-5960 Negative_regulation denotes absence
T3051 5964-5973 Positive_regulation denotes activated
T3052 5974-5979 Protein denotes Stat6
T3053 5985-5988 Protein denotes IL4
T3054 5989-5995 Regulation denotes target
T3055 6051-6061 Positive_regulation denotes activation
T3056 6065-6070 Protein denotes Stat3
T3057 6095-6097 Protein denotes Rb
T3058 6141-6144 Protein denotes Akt
T3059 6156-6161 Protein denotes Stat3
T3060 6217-6221 Protein denotes LMP1
T3061 6380-6391 Regulation denotes deregulated true true
T3062 6380-6391 Regulation denotes deregulated true true
T3063 6497-6501 Protein denotes LMP1
T3064 6585-6588 Protein denotes Akt
T3065 6600-6605 Protein denotes Stat3
T3972 6684-6695 Positive_regulation denotes High Levels
T3973 6699-6703 Protein denotes LMP1
T3974 6704-6714 Gene_expression denotes Expression
T3975 6759-6763 Protein denotes LMP1
T3976 6764-6774 Gene_expression denotes expression
T3977 6814-6831 Regulation denotes under the control
T3978 6937-6941 Protein denotes LMP1
T3979 6942-6952 Gene_expression denotes expression
T3980 6957-6967 Positive_regulation denotes restricted
T3981 7068-7072 Protein denotes LMP1
T3982 7073-7083 Gene_expression denotes expression
T3983 7193-7197 Protein denotes CD19
T3984 7286-7290 Protein denotes LMP1
T3985 7295-7305 Gene_expression denotes detectable
T3986 7309-7313 Protein denotes LMP1
T3987 7368-7372 Protein denotes LMP1
T3988 7373-7383 Gene_expression denotes expression
T3989 7388-7396 Positive_regulation denotes stronger
T3990 7513-7525 Positive_regulation denotes higher level
T3991 7529-7533 Protein denotes LMP1
T3992 7593-7603 Gene_expression denotes expression true
T3993 7607-7611 Protein denotes LMP1
T3994 7730-7738 Gene_expression denotes detected
T3995 7739-7743 Protein denotes LMP1
T3996 7867-7871 Protein denotes LMP1
T3997 7872-7882 Gene_expression denotes expression
T3998 7906-7912 Positive_regulation denotes strong
T3999 7913-7917 Protein denotes LMP1
T4000 7979-7985 Positive_regulation denotes weakly true
T4001 7990-7994 Protein denotes LMP1
T4002 8026-8030 Protein denotes LMP1
T4003 8031-8041 Gene_expression denotes expression
T4004 8051-8061 Positive_regulation denotes abundantly
T4005 8093-8100 Positive_regulation denotes intense
T4006 8101-8105 Protein denotes LMP1
T4007 8143-8152 Positive_regulation denotes increased
T4008 8153-8157 Protein denotes LMP1
T4009 8224-8232 Positive_regulation denotes increase
T4010 8236-8240 Protein denotes LMP1
T4011 8241-8251 Gene_expression denotes expression
T4012 8281-8291 Gene_expression denotes expressing
T4013 8292-8303 Positive_regulation denotes high levels
T4014 8307-8311 Protein denotes LMP1
T4015 8338-8342 Positive_regulation denotes high
T4016 8343-8347 Protein denotes LMP1
T4017 8348-8358 Gene_expression denotes expression
T4018 8442-8451 Positive_regulation denotes increased
T4019 8452-8458 Gene_expression denotes levels
T4020 8462-8466 Protein denotes LMP1
T5364 9020-9024 Protein denotes LMP1
T5365 9099-9103 Protein denotes LMP1
T5366 9198-9202 Protein denotes LMP1
T5367 9203-9213 Gene_expression denotes expression
T5368 9455-9459 Protein denotes LMP1
T5369 9493-9497 Protein denotes LMP1
T5370 9621-9625 Protein denotes LMP1
T5371 9786-9789 Protein denotes CD5
T5372 9802-9805 Protein denotes CD5
T5373 9923-9926 Protein denotes CD5
T5374 9952-9956 Protein denotes LMP1
T5375 10004-10007 Protein denotes CD5
T5376 10323-10327 Protein denotes LMP1
T5377 10419-10423 Protein denotes CD19
T5378 10424-10427 Protein denotes CD5
T5379 10459-10463 Protein denotes CD19
T5380 10464-10467 Protein denotes CD5
T5381 10487-10491 Protein denotes LMP1
T5382 11723-11727 Protein denotes LMP1
T5383 11889-11893 Protein denotes LMP1
T5384 12526-12530 Protein denotes LMP1
T5385 12917-12927 Gene_expression denotes expression
T5386 12931-12935 Protein denotes LMP1
T6241 13052-13056 Protein denotes LMP1
T6242 13159-13163 Protein denotes CD40
T6243 13164-13172 Binding denotes ligation
T6244 13198-13201 Protein denotes IL4
T6245 13231-13235 Protein denotes LMP1
T6246 13343-13346 Protein denotes IL4
T6247 13620-13623 Protein denotes IL4
T6248 13633-13637 Negative_regulation denotes lack
T6249 13641-13645 Protein denotes CD40
T6250 13646-13654 Binding denotes ligation
T6251 13681-13685 Protein denotes LMP1
T6252 13735-13742 Negative_regulation denotes absence
T6253 13746-13749 Protein denotes IL4
T6254 13795-13798 Protein denotes IL4
T6255 13814-13818 Protein denotes LMP1
T6256 13889-13896 Negative_regulation denotes absence
T6257 13900-13903 Protein denotes IL4
T6258 13921-13925 Protein denotes LMP1
T6259 15289-15293 Protein denotes CD19
T6260 15345-15349 Protein denotes LMP1
T6261 15414-15418 Protein denotes LMP1
T6262 15493-15497 Protein denotes LMP1
T6263 15582-15585 Protein denotes IL4
T6264 15651-15654 Protein denotes IL4
T6265 15727-15731 Protein denotes LMP1
T6266 15777-15780 Protein denotes IL4
T6267 15876-15879 Protein denotes IL4
T6268 15942-15946 Protein denotes LMP1
T6269 15983-15993 Gene_expression denotes expression
T6270 15997-16001 Protein denotes LMP1
T6271 16096-16100 Protein denotes LMP1
T6272 16101-16111 Gene_expression denotes expression
T6273 16311-16315 Protein denotes LMP1
T6274 16443-16447 Protein denotes LMP1
T6275 16448-16456 Negative_regulation denotes negative
T6276 16551-16558 Gene_expression denotes express
T6277 16564-16568 Positive_regulation denotes high
T6278 16579-16583 Protein denotes LMP1
T6279 16591-16595 Protein denotes LMP1
T6280 16604-16607 Positive_regulation denotes low true
T6281 16618-16622 Protein denotes LMP1
T6282 16637-16641 Protein denotes LMP1
T6283 16681-16685 Protein denotes LMP1
T6284 16794-16797 Protein denotes IL4
T6285 16823-16826 Protein denotes IL4
T7147 9621-9625 Protein denotes LMP1
T7148 17038-17041 Protein denotes IL4
T7149 17046-17051 Protein denotes Stat6
T7150 17085-17088 Protein denotes IL4
T7151 17124-17127 Protein denotes IL4
T7152 17128-17138 Gene_expression denotes expression
T7153 17140-17143 Protein denotes IL4
T7154 17144-17157 Transcription denotes transcription true
T7155 17207-17210 Protein denotes IL4
T7156 17211-17224 Transcription denotes transcription
T7157 17328-17331 Protein denotes IL4
T7158 17332-17345 Transcription denotes transcription true
T7159 17368-17372 Protein denotes CD19
T7160 17443-17447 Protein denotes LMP1
T7161 17504-17509 Protein denotes GAPDH
T7162 17514-17517 Protein denotes L32
T7163 17567-17576 Positive_regulation denotes Activated
T7164 17577-17582 Protein denotes Stat6
T7165 17584-17590 Protein denotes pStat6
T7166 17595-17601 Regulation denotes target
T7167 17609-17621 Protein denotes IL4 receptor
T7168 17665-17669 Protein denotes LMP1
T7169 17773-17777 Protein denotes LMP1
T7170 17884-17887 Protein denotes IL4
T7171 17888-17895 Positive_regulation denotes induced
T7172 17896-17901 Protein denotes Stat6
T7173 17902-17917 Phosphorylation denotes phosphorylation
T7174 19044-19047 Protein denotes IL4
T7175 19288-19291 Protein denotes IL4
T7176 19357-19360 Protein denotes IL4
T7177 19419-19422 Protein denotes IL4
T7178 19458-19462 Protein denotes LMP1
T7179 19532-19536 Protein denotes LMP1
T7180 19585-19588 Protein denotes IL4
T7181 19619-19624 Protein denotes Stat6
T9316 19637-19641 Protein denotes LMP1
T9317 19642-19653 Positive_regulation denotes Upregulates
T9318 19654-19658 Protein denotes IL10
T9319 19678-19687 Positive_regulation denotes Activates
T9320 19688-19693 Protein denotes Stat3
T9321 19850-19854 Protein denotes CD19
T9322 19906-19909 Protein denotes IL4
T9323 19911-19914 Protein denotes IL5
T9324 19916-19920 Protein denotes IL10
T9325 19922-19926 Protein denotes IL13
T9326 19928-19932 Protein denotes IL15
T9327 19934-19937 Protein denotes IL9
T9328 19939-19942 Protein denotes IL2
T9329 19944-19947 Protein denotes IL6
T9330 19953-19957 Protein denotes IFNγ
T9331 20065-20068 Protein denotes L32
T9332 20104-20112 Gene_expression denotes detected true
T9333 20104-20112 Gene_expression denotes detected true
T9334 20104-20112 Gene_expression denotes detected true
T9335 20104-20112 Gene_expression denotes detected true
T9336 20104-20112 Gene_expression denotes detected true
T9397 21819-21823 Protein denotes LMP1
T9398 21824-21834 Gene_expression denotes expression
T9399 21853-21857 Protein denotes IL10
T9400 21858-21867 Positive_regulation denotes induction
T9401 21913-21922 Positive_regulation denotes induction
T9402 21926-21930 Protein denotes IL10
T9403 22014-22022 Regulation denotes affected true
T9404 22026-22030 Protein denotes LMP1
T9405 22032-22044 Negative_regulation denotes Neutralizing
T9406 22059-22063 Protein denotes IL10
T9407 22185-22195 Positive_regulation denotes activation true
T9408 22199-22204 Protein denotes Stat3
T9409 22282-22286 Protein denotes IL10
T9410 22312-22318 Protein denotes pStat3
T9411 22335-22344 Positive_regulation denotes activated
T9412 22391-22395 Protein denotes LMP1
T9413 22452-22456 Protein denotes IL10
T9414 22457-22465 Positive_regulation denotes enhanced
T9415 22466-22472 Protein denotes pStat3
T9416 22473-22483 Positive_regulation denotes activation
T9417 22560-22564 Protein denotes IL10
T9418 22650-22655 Protein denotes Stat3
T9419 22656-22666 Positive_regulation denotes activation
T9420 22686-22694 Positive_regulation denotes enhanced true
T9421 22698-22702 Protein denotes IL10
T9422 22718-22737 Negative_regulation denotes neutralizing effect
T9423 22750-22754 Protein denotes IL10
T9424 22799-22803 Protein denotes IL10
T9425 22814-22818 Protein denotes IL10
T9426 23916-23923 Entity denotes Nuclear
T9427 23924-23937 Localization denotes translocation
T9428 23941-23947 Protein denotes pStat3
T9429 23953-23964 Positive_regulation denotes consequence
T9430 23968-23978 Positive_regulation denotes activation
T9431 23984-23991 Entity denotes nuclear
T9432 23992-23998 Protein denotes pStat3
T9433 24007-24015 Localization denotes detected true
T9434 24096-24103 Entity denotes nuclear
T9435 24104-24110 Protein denotes pStat3
T9436 24115-24125 Localization denotes detectable
T9437 24129-24133 Protein denotes LMP1
T9438 24182-24190 Localization denotes detected
T9439 24213-24217 Protein denotes LMP1
T9440 24269-24279 Positive_regulation denotes activation
T9441 24269-24279 Positive_regulation denotes activation
T9442 24283-24289 Protein denotes pStat3
T9443 24311-24316 Protein denotes Stat3
T9444 24331-24336 Protein denotes Stat3
T9445 24362-24366 Protein denotes LMP1
T11445 24399-24403 Protein denotes LMP1
T11446 24414-24417 Protein denotes Akt
T11447 24448-24450 Protein denotes Rb
T11448 24470-24474 Protein denotes LMP1
T11449 24512-24520 Positive_regulation denotes requires
T11450 24521-24531 Positive_regulation denotes activation
T11451 24544-24547 Protein denotes Akt
T11452 24567-24576 Positive_regulation denotes activated
T11453 24577-24581 Protein denotes pAkt
T11454 24693-24696 Protein denotes Akt
T11455 24723-24727 Protein denotes LMP1
T11456 24745-24749 Protein denotes pAkt
T11457 24820-24824 Protein denotes CD19
T11458 24849-24853 Protein denotes LMP1
T11459 24877-24886 Positive_regulation denotes increased
T11460 24897-24901 Protein denotes pAkt
T11461 24978-24982 Protein denotes LMP1
T11462 25037-25045 Positive_regulation denotes increase true
T11463 25046-25050 Protein denotes pAkt
T11464 25063-25066 Protein denotes Akt
T11465 25067-25073 Binding denotes target
T11466 25074-25100 Protein denotes glycogen synthase kinase 3
T11467 25102-25106 Protein denotes GSK3
T11468 25111-25122 Negative_regulation denotes inactivated
T11469 25152-25161 Positive_regulation denotes increased true
T11470 25162-25176 Phosphorylation denotes phosphorylated
T11471 25177-25181 Protein denotes GSK3
T11472 25316-25320 Protein denotes GSK3
T11473 25330-25336 Binding denotes target true
T11474 25340-25349 Positive_regulation denotes activated
T11475 25350-25353 Protein denotes Akt
T11476 25361-25365 Protein denotes LMP1
T11477 25420-25430 Positive_regulation denotes activation
T11478 25434-25437 Protein denotes Akt
T11479 25446-25461 Phosphorylation denotes phosphorylation
T11480 25465-25469 Protein denotes GSK3
T11481 25567-25576 Positive_regulation denotes activated true
T11482 25577-25580 Protein denotes Akt
T11483 25605-25619 Phosphorylation denotes phosphorylated
T11484 25620-25624 Protein denotes GSK3
T11485 25693-25703 Regulation denotes regulation
T11486 25707-25711 Protein denotes GSK3
T11487 26410-26413 Protein denotes Akt
T11488 26414-26421 Binding denotes targets true
T11489 26447-26453 Protein denotes p-mTOR
T11490 26469-26478 Positive_regulation denotes Activated
T11491 26479-26485 Protein denotes p-mTOR
T11492 26494-26503 Positive_regulation denotes increased true
T11493 26507-26511 Protein denotes LMP1
T11494 26590-26598 Regulation denotes affected true
T11495 26602-26606 Protein denotes LMP1
T11496 26607-26614 Positive_regulation denotes induced
T11497 26615-26618 Protein denotes Akt
T11498 26619-26629 Positive_regulation denotes activation
T11499 26691-26694 Protein denotes Akt
T11500 26962-26967 Protein denotes FoxO1
T11501 26990-26997 Regulation denotes targets
T11502 26998-27003 Protein denotes FoxO1
T11503 27043-27048 Protein denotes FoxO1
T11504 27084-27089 Protein denotes FoxO1
T11505 27139-27144 Protein denotes FoxO1
T11506 27165-27174 Negative_regulation denotes decreased
T11507 27192-27196 Protein denotes LMP1
T11508 27318-27321 Protein denotes Akt
T11509 27373-27376 Protein denotes Akt
T11510 27377-27387 Positive_regulation denotes activation
T11511 27396-27402 Positive_regulation denotes induce true
T11512 27403-27408 Protein denotes FoxO1
T11513 27409-27420 Negative_regulation denotes degradation
T11514 27424-27428 Protein denotes LMP1
T11515 27449-27452 Protein denotes Akt
T11516 27473-27482 Regulation denotes regulator true true
T11517 27486-27491 Protein denotes FoxO1
T11518 27646-27656 Gene_expression denotes expression
T11519 27678-27681 Protein denotes p27
T11520 27691-27695 Protein denotes LMP1
T11521 27756-27759 Protein denotes p27
T11522 27777-27781 Protein denotes Cdk2
T11523 27860-27862 Protein denotes Rb
T11524 27892-27896 Protein denotes LMP1
T11525 27940-27942 Protein denotes Rb
T11526 27987-27990 Protein denotes pRb
T11527 27992-27996 Protein denotes Cdk2
T11528 28002-28005 Protein denotes p27
T11529 28032-28036 Protein denotes CD19
T11530 28061-28065 Protein denotes LMP1
T11531 28089-28097 Positive_regulation denotes enhanced
T11532 28089-28097 Positive_regulation denotes enhanced
T11533 28108-28111 Protein denotes pRb
T11534 28152-28154 Protein denotes Rb
T11535 28166-28170 Protein denotes Cdk2
T11536 28266-28270 Protein denotes LMP1
T11537 28297-28300 Positive_regulation denotes led
T11538 28304-28313 Positive_regulation denotes increased
T11539 28324-28326 Protein denotes Rb
T11540 28344-28355 Positive_regulation denotes high levels
T11541 28359-28363 Protein denotes Cdk2
T11542 28369-28378 Negative_regulation denotes decreased
T11543 28389-28392 Protein denotes p27
T11544 28435-28437 Protein denotes Rb
T11545 28464-28468 Protein denotes LMP1
T11546 28537-28541 Negative_regulation denotes loss
T11547 28545-28550 Protein denotes FoxO1
T11548 28555-28564 Negative_regulation denotes decreased
T11549 28565-28568 Protein denotes p27
T13929 28571-28575 Protein denotes LMP1
T13930 28633-28636 Protein denotes Akt
T13931 28648-28653 Protein denotes Stat3
T13932 28743-28747 Protein denotes LMP1
T13933 28798-28802 Protein denotes LMP1
T13934 28852-28862 Negative_regulation denotes inhibitors
T13935 28852-28862 Negative_regulation denotes inhibitors
T13936 28852-28862 Negative_regulation denotes inhibitors
T13937 28867-28870 Protein denotes Akt
T13938 28878-28883 Protein denotes Stat3
T13939 28885-28889 Protein denotes mTOR
T13940 29103-29107 Protein denotes LMP1
T13941 29319-29327 Negative_regulation denotes inhibits
T13942 29332-29342 Positive_regulation denotes activation
T13943 29346-29349 Protein denotes Akt
T13944 29432-29435 Protein denotes Akt
T13945 29583-29593 Positive_regulation denotes activation
T13946 29597-29600 Protein denotes Akt
T13947 29644-29648 Protein denotes LMP1
T13948 29762-29776 Phosphorylation denotes phosphorylated
T13949 29762-29776 Phosphorylation denotes phosphorylated
T13950 29777-29780 Protein denotes Akt
T13951 29782-29787 Protein denotes Stat3
T13952 29809-29813 Protein denotes IκBα
T13953 29865-29872 Negative_regulation denotes blocked
T13954 29873-29888 Phosphorylation denotes phosphorylation
T13955 29892-29895 Protein denotes Akt
T13956 29901-29915 Phosphorylation denotes phosphorylated
T13957 29916-29919 Protein denotes Akt
T13958 29934-29942 Positive_regulation denotes detected true
T13959 29954-29968 Phosphorylation denotes Phosphorylated
T13960 29954-29968 Phosphorylation denotes Phosphorylated
T13961 29969-29974 Protein denotes Stat3
T13962 29979-29983 Protein denotes IκBα
T13963 30066-30073 Regulation denotes targets true
T13964 30074-30077 Protein denotes Akt
T13965 30087-30090 Protein denotes Akt
T13966 30091-30101 Positive_regulation denotes activation
T13967 31595-31599 Protein denotes LMP1
T13968 31775-31789 Phosphorylation denotes Phosphorylated
T13969 31775-31789 Phosphorylation denotes Phosphorylated
T13970 31790-31793 Protein denotes Akt
T13971 31795-31800 Protein denotes Stat3
T13972 31812-31816 Protein denotes IκBα
T13973 31828-31835 Positive_regulation denotes present
T13974 31828-31835 Positive_regulation denotes present
T13975 31828-31835 Positive_regulation denotes present
T13976 31887-31895 Positive_regulation denotes detected true
T13977 31887-31895 Positive_regulation denotes detected true
T13978 31887-31895 Positive_regulation denotes detected true
T13979 31979-31983 Protein denotes LMP1
T13980 32046-32053 Regulation denotes effects true true
T13981 32046-32053 Regulation denotes effects true true
T13982 32057-32067 Positive_regulation denotes activation
T13983 32057-32067 Positive_regulation denotes activation
T13984 32071-32074 Protein denotes Akt
T13985 32078-32083 Protein denotes Stat3
T13986 32100-32108 Negative_regulation denotes inhibits
T13987 32109-32119 Positive_regulation denotes activation
T13988 32123-32128 Protein denotes Stat3
T13989 32173-32177 Protein denotes JAK2
T13990 32261-32270 Positive_regulation denotes activated
T13991 32271-32276 Protein denotes Stat3
T13992 32294-32298 Protein denotes LMP1
T13993 32486-32500 Phosphorylation denotes Phosphorylated
T13994 32486-32500 Phosphorylation denotes Phosphorylated
T13995 32501-32504 Protein denotes Akt
T13996 32506-32511 Protein denotes Stat3
T13997 32523-32527 Protein denotes IκBα
T13998 32537-32547 Positive_regulation denotes detectable true
T13999 32537-32547 Positive_regulation denotes detectable true
T14000 32537-32547 Positive_regulation denotes detectable true
T14001 32610-32619 Negative_regulation denotes decreased
T14002 32610-32619 Negative_regulation denotes decreased
T14003 32610-32619 Negative_regulation denotes decreased
T14004 32693-32702 Negative_regulation denotes inhibitor
T14005 32706-32711 Protein denotes Stat3
T14006 32774-32777 Protein denotes Akt
T14007 32779-32784 Protein denotes Stat3
T14008 32799-32803 Protein denotes IκBα
T14009 32818-32826 Regulation denotes affected true
T14010 32867-32877 Negative_regulation denotes inhibition
T14011 32881-32886 Protein denotes Stat3
T14012 32912-32916 Protein denotes LMP1
T14013 32964-32969 Protein denotes Stat3
T14014 32970-32980 Negative_regulation denotes inhibition
T14015 33024-33027 Protein denotes Akt
T14016 33048-33052 Protein denotes LMP1
T14017 33124-33128 Protein denotes LMP1
T14018 33254-33263 Negative_regulation denotes inhibitor
T14019 33254-33263 Negative_regulation denotes inhibitor
T14020 33267-33271 Protein denotes MEK1
T14021 33272-33273 Protein denotes 2
T14022 33491-33495 Protein denotes LMP1
T14023 33583-33587 Protein denotes LMP1
T14024 33770-33773 Protein denotes Akt
T14025 33785-33790 Protein denotes Stat3
T14026 33900-33909 Negative_regulation denotes inhibitor
T14027 33913-33917 Protein denotes mTOR
T14028 34013-34017 Protein denotes mTOR
T14029 34025-34033 Regulation denotes targeted true
T14030 34037-34040 Protein denotes Akt
T14031 34055-34059 Protein denotes LMP1
T18120 34182-34186 Protein denotes LMP1
T18121 34224-34228 Protein denotes LMP1
T18122 34334-34340 Positive_regulation denotes higher
T18123 34341-34351 Gene_expression denotes expression
T18124 34362-34366 Protein denotes LMP1
T18125 34403-34407 Protein denotes LMP1
T18126 34548-34552 Protein denotes LMP1
T18127 34660-34664 Protein denotes LMP1
T18128 34758-34762 Protein denotes LMP1
T18129 34863-34867 Protein denotes LMP1
T18130 35010-35014 Protein denotes LMP1
T18131 35076-35080 Protein denotes CD40
T18132 35081-35090 Negative_regulation denotes deficient
T18133 35226-35230 Protein denotes CD40
T18134 35244-35248 Protein denotes LMP1
T18135 35333-35343 Gene_expression denotes expression
T18136 35347-35351 Protein denotes LMP1
T18137 35556-35560 Protein denotes LMP1
T18147 37208-37218 Gene_expression denotes expression
T18148 37222-37226 Protein denotes LMP1
T18149 37518-37522 Protein denotes LMP1
T18150 37644-37648 Protein denotes LMP1
T18151 37832-37844 Positive_regulation denotes upregulation
T18152 37848-37852 Protein denotes IL10
T18153 37881-37886 Protein denotes Stat3
T18154 37934-37937 Protein denotes Akt
T18155 37949-37954 Protein denotes Stat3
T18156 37983-37992 Positive_regulation denotes Induction
T18157 37996-38000 Protein denotes IL10
T18158 38194-38198 Protein denotes LMP1
T18159 38217-38226 Positive_regulation denotes stimulate
T18160 38227-38231 Protein denotes IL10
T18161 38232-38242 Gene_expression denotes expression
T18162 38311-38316 Protein denotes Stat3
T18163 38335-38344 Positive_regulation denotes activated
T18164 38372-38381 Positive_regulation denotes induction
T18165 38385-38389 Protein denotes IL10
T18166 38402-38409 Positive_regulation denotes enhance true
T18167 38410-38415 Protein denotes Stat3
T18168 38416-38426 Positive_regulation denotes activation
T18169 38454-38458 Protein denotes IL10
T18170 38490-38494 Protein denotes LMP1
T18171 38628-38632 Protein denotes LMP1
T18172 38660-38664 Protein denotes LMP1
T18173 38744-38748 Protein denotes CD40
T18174 38781-38790 Negative_regulation denotes deficient
T18175 38781-38790 Negative_regulation denotes deficient
T18176 38795-38799 Protein denotes cRel
T18177 38807-38810 Protein denotes p85
T18178 38887-38891 Protein denotes CD40
T18179 38892-38900 Binding denotes ligation
T18180 38940-38944 Protein denotes cRel
T18181 38961-38970 Positive_regulation denotes activated
T18182 38993-38997 Protein denotes LMP1
T18183 39036-39046 Positive_regulation denotes activation
T18184 39050-39054 Protein denotes cRel
T18185 39143-39147 Protein denotes CD40
T18186 39171-39175 Protein denotes LMP1
T18187 39176-39183 Positive_regulation denotes induces
T18188 39176-39183 Positive_regulation denotes induces
T18189 39220-39230 Positive_regulation denotes activation
T18190 39234-39237 Protein denotes Akt
T18191 39242-39252 Positive_regulation denotes activation
T18192 39280-39284 Protein denotes cRel
T18193 39286-39290 Protein denotes CD40
T18194 39296-39303 Positive_regulation denotes induces
T18195 39304-39318 Negative_regulation denotes downregulation
T18196 39347-39350 Protein denotes p27
T18197 39392-39396 Protein denotes LMP1
T18198 39421-39430 Negative_regulation denotes decreased
T18199 39441-39444 Protein denotes p27
T18200 39450-39465 Phosphorylation denotes phosphorylation
T18201 39469-39471 Protein denotes Rb
T18202 39476-39485 Positive_regulation denotes increased
T18203 39486-39490 Protein denotes Cdk2
T18204 39518-39522 Protein denotes LMP1
T18205 39556-39558 Protein denotes Rb
T18206 39681-39692 Positive_regulation denotes requirement
T18207 39697-39700 Protein denotes Akt
T18208 39701-39711 Positive_regulation denotes activation
T18209 39794-39797 Protein denotes Akt
T18210 39798-39807 Negative_regulation denotes inhibitor
T18211 39822-39831 Positive_regulation denotes activated
T18212 39832-39836 Protein denotes pAkt
T18213 39845-39849 Positive_regulation denotes lead true
T18214 39845-39849 Positive_regulation denotes lead true
T18215 39853-39868 Phosphorylation denotes phosphorylation
T18216 39873-39885 Negative_regulation denotes inactivation
T18217 39911-39915 Protein denotes GSK3
T18218 40074-40078 Protein denotes LMP1
T18219 40123-40127 Protein denotes LMP1
T18220 40226-40233 Negative_regulation denotes absence
T18221 40237-40246 Positive_regulation denotes activated
T18222 40247-40253 Protein denotes p-mTOR
T18223 40308-40311 Protein denotes Akt
T18224 40365-40371 Regulation denotes target
T18225 40386-40396 Negative_regulation denotes inhibition
T18226 40404-40409 Protein denotes Fox01
T18227 40433-40443 Negative_regulation denotes Repression
T18228 40486-40491 Protein denotes FoxO1
T18229 40523-40530 Negative_regulation denotes inhibit
T18230 40531-40541 Gene_expression denotes expression
T18231 40545-40549 Protein denotes bcl6
T18232 40652-40656 Protein denotes CD40
T18233 40750-40754 Protein denotes CD40
T18234 40777-40781 Protein denotes LMP1
T18235 40861-40865 Protein denotes LMP1
T18236 40901-40915 Negative_regulation denotes downregulation
T18237 40919-40923 Protein denotes bcl6
T18238 40971-40981 Gene_expression denotes expression
T18239 40971-40981 Gene_expression denotes expression
T18240 40985-40989 Protein denotes LMP1
T18241 40994-40998 Protein denotes bcl6
T18242 41012-41021 Negative_regulation denotes exclusive
T18243 41012-41021 Negative_regulation denotes exclusive
T18244 41012-41021 Negative_regulation denotes exclusive
T18245 41012-41021 Negative_regulation denotes exclusive
T18246 41068-41072 Protein denotes LMP1
T18247 41141-41151 Positive_regulation denotes activation
T18248 41155-41158 Protein denotes Akt
T18249 41167-41171 Negative_regulation denotes lack
T18250 41175-41180 Protein denotes Fox01
T18251 41216-41220 Protein denotes LMP1
T18252 41221-41228 Regulation denotes affects true
T18253 41229-41233 Protein denotes bcl6
T18254 41264-41271 Regulation denotes pathway
T18255 41273-41283 Regulation denotes regulation
T18256 41273-41283 Regulation denotes regulation
T18257 41354-41357 Protein denotes p27
T18258 41362-41370 Protein denotes CyclinD2
T18259 41427-41431 Negative_regulation denotes loss
T18260 41435-41440 Protein denotes FoxO1
T18261 41441-41451 Gene_expression denotes expression
T18262 41470-41480 Positive_regulation denotes correlated
T18263 41488-41492 Negative_regulation denotes loss
T18264 41496-41499 Protein denotes p27
T18265 41520-41528 Protein denotes CyclinD2
T18266 41555-41566 Positive_regulation denotes upregulated
T18267 41570-41574 Protein denotes LMP1
T18268 41594-41599 Protein denotes FoxO1
T18269 41683-41687 Protein denotes LMP1
T18270 41856-41861 Protein denotes Stat3
T18271 41873-41882 Negative_regulation denotes decreased
T18272 41883-41886 Protein denotes p27
T18273 41902-41905 Protein denotes Akt
T18274 42026-42029 Protein denotes Akt
T18275 42041-42046 Protein denotes Stat3
T18276 42153-42157 Protein denotes LMP1
T18277 42301-42305 Protein denotes LMP1
T18278 42468-42472 Protein denotes LMP1
T18589 42576-42580 Protein denotes LMP1
T18590 42729-42733 Protein denotes LMP1
T19021 43727-43731 Protein denotes CD19
T19022 44082-44086 Protein denotes CD19
T19023 44186-44189 Protein denotes IL4
T19024 44232-44236 Protein denotes IL10
T19025 44274-44278 Protein denotes IL10
T19622 44736-44739 Protein denotes IL4
T19623 44823-44826 Protein denotes IL4
T19624 45151-45154 Protein denotes IL4
T19625 45176-45179 Protein denotes IL4
T20034 46086-46090 Protein denotes LMP1
T20035 46135-46139 Protein denotes LMP1
T20036 46284-46288 Protein denotes LMP1
T20037 46674-46679 Protein denotes Stat3
T20761 47595-47599 Protein denotes CD19
T20762 48343-48350 Protein denotes Rnase A
T20763 48355-48357 Protein denotes T1
T21023 48835-48853 Protein denotes Taq DNA polymerase
T21384 49932-49942 Protein denotes peroxidase
T21758 50409-50413 Protein denotes CD19
T21759 50459-50463 Protein denotes LMP1
T21760 50508-50510 Protein denotes Rb
T21761 50531-50535 Protein denotes Cdk2
T21762 50618-50621 Protein denotes CD5
T21763 50678-50682 Protein denotes LMP1
T21764 50757-50761 Protein denotes pAkt
T21765 50777-50783 Protein denotes pGSK3α
T21766 50784-50785 Protein denotes β
T21767 50802-50808 Protein denotes pStat3
T21768 50824-50830 Protein denotes pStat6
T21769 50846-50851 Protein denotes pmTOR
T21770 50868-50873 Protein denotes Stat6
T21771 50880-50883 Protein denotes Akt
T21772 50890-50895 Protein denotes FoxO1
T21773 50906-50909 Protein denotes p27
T21774 50958-50963 Protein denotes Stat3
T21775 50978-50982 Protein denotes IκBα
T21776 51005-51012 Protein denotes β actin
T21777 51083-51087 Protein denotes GSK3
T21778 51142-51145 Protein denotes pRb
T22063 8478-8482 Positive_regulation denotes High
T22064 8483-8487 Protein denotes LMP1
T22065 8488-8498 Gene_expression denotes Expression
T22066 8543-8547 Protein denotes LMP1
T22067 8548-8558 Gene_expression denotes expression
T22068 8611-8615 Protein denotes CD19
T22069 8697-8701 Protein denotes LMP1
T22070 8789-8793 Protein denotes LMP1
T22609 10554-10558 Protein denotes LMP1
T22610 10673-10677 Protein denotes LMP1
T22611 10718-10722 Protein denotes CD19
T22612 10736-10739 Protein denotes CD5
T22613 10855-10859 Protein denotes LMP1
T22614 10924-10928 Protein denotes LMP1
T22615 11117-11121 Protein denotes LMP1
T22616 11155-11159 Protein denotes CD19
T22617 11160-11163 Protein denotes CD5
T22618 11190-11194 Protein denotes CD19
T22619 11195-11198 Protein denotes CD5
T22620 11332-11336 Protein denotes LMP1
T22621 11436-11440 Protein denotes CD19
T22622 11464-11468 Protein denotes LMP1
T23081 14367-14371 Protein denotes LMP1
T23082 14465-14469 Protein denotes LMP1
T23083 14568-14571 Protein denotes IL4
T23084 14769-14773 Protein denotes LMP1
T23085 14813-14817 Protein denotes LMP1
T23086 14861-14865 Protein denotes CD19
T23087 14897-14901 Protein denotes LMP1
T23088 15006-15009 Protein denotes IL4
T23089 15079-15083 Protein denotes LMP1
T23090 15135-15138 Protein denotes IL4
T23091 15193-15197 Protein denotes LMP1
T23634 17955-17959 Protein denotes LMP1
T23635 18011-18014 Protein denotes IL4
T23636 18015-18020 Protein denotes Stat6
T23637 18073-18076 Protein denotes IL4
T23638 18105-18109 Protein denotes CD19
T23639 18124-18128 Protein denotes LMP1
T23640 18157-18160 Protein denotes L32
T23641 18165-18170 Protein denotes GAPDH
T23642 18315-18319 Protein denotes LMP1
T23643 18340-18349 Positive_regulation denotes activated true
T23644 18350-18356 Protein denotes pStat6
T23645 18382-18386 Protein denotes CD19
T23646 18465-18468 Protein denotes IL4
T23647 18636-18640 Protein denotes LMP1
T23648 18681-18684 Protein denotes IL4
T23649 18713-18716 Protein denotes IL4
T23650 18807-18811 Protein denotes LMP1
T24273 22890-22894 Protein denotes LMP1
T24274 22895-22906 Positive_regulation denotes Upregulates
T24275 22907-22911 Protein denotes IL10
T24276 22912-22922 Gene_expression denotes Expression
T24277 22942-22951 Positive_regulation denotes Activates
T24278 22952-22957 Protein denotes Stat3
T24279 22971-22981 Transcription denotes expression true
T24280 22971-22981 Transcription denotes expression true
T24281 22971-22981 Transcription denotes expression true
T24282 22985-22989 Protein denotes IL10
T24283 22991-22995 Protein denotes IL15
T24284 23001-23005 Protein denotes IFNγ
T24285 23021-23025 Protein denotes LMP1
T24286 23046-23050 Protein denotes CD19
T24287 23278-23281 Protein denotes L32
T24288 23296-23299 Protein denotes L32
T24289 23391-23400 Positive_regulation denotes activated true
T24290 23401-23407 Protein denotes pStat3
T24291 23429-23433 Protein denotes CD19
T24292 23448-23452 Protein denotes LMP1
T24293 23539-23543 Protein denotes IL10
T24294 23572-23576 Protein denotes IL10
T24295 23657-23661 Protein denotes LMP1
T24296 23742-23747 Protein denotes Stat3
T24297 23824-23833 Positive_regulation denotes activated true
T24298 23842-23848 Protein denotes pStat3
T24299 23874-23878 Protein denotes LMP1
T24726 25723-25727 Protein denotes LMP1
T24727 25738-25741 Protein denotes Akt
T24728 25772-25774 Protein denotes Rb
T24729 25845-25849 Protein denotes CD19
T24730 25879-25883 Protein denotes LMP1
T24731 25904-25907 Protein denotes Akt
T24732 25945-25949 Protein denotes pAkt
T24733 25965-25972 Regulation denotes targets
T24734 25965-25972 Regulation denotes targets
T24735 25984-25995 Positive_regulation denotes inactivated true true
T24736 25984-25995 Positive_regulation denotes inactivated true true
T24737 25996-26002 Protein denotes pGSK3α
T24738 26003-26004 Protein denotes β
T24739 26014-26023 Positive_regulation denotes activated true
T24740 26024-26030 Protein denotes p-mTOR
T24741 26052-26057 Protein denotes FoxO1
T24742 26112-26116 Protein denotes GSK3
T24743 26252-26254 Protein denotes Rb
T24744 26276-26285 Positive_regulation denotes activated true
T24745 26286-26289 Protein denotes pRb
T24746 26311-26315 Protein denotes Cdk2
T24747 26338-26341 Protein denotes p27
T25191 30201-30204 Protein denotes Akt
T25192 30216-30221 Protein denotes Stat3
T25193 30347-30351 Protein denotes LMP1
T25194 30387-30391 Protein denotes LMP1
T25195 30458-30468 Negative_regulation denotes inhibitors
T25196 30458-30468 Negative_regulation denotes inhibitors
T25197 30458-30468 Negative_regulation denotes inhibitors
T25198 30458-30468 Negative_regulation denotes inhibitors
T25199 30458-30468 Negative_regulation denotes inhibitors
T25200 30486-30490 Protein denotes mTOR
T25201 30504-30507 Protein denotes Akt
T25202 30523-30527 Protein denotes MEK1
T25203 30528-30529 Protein denotes 2
T25204 30558-30563 Protein denotes Stat3
T25205 30739-30743 Protein denotes LMP1
T25206 30796-30800 Protein denotes LMP1
T25207 30859-30863 Protein denotes LMP1
T25494 30934-30937 Protein denotes Akt
T25495 30949-30954 Protein denotes Stat3
T25496 31068-31072 Protein denotes LMP1
T25497 31098-31101 Protein denotes Akt
T25498 31113-31118 Protein denotes Stat3
T25499 31157-31160 Protein denotes Akt
T25500 31161-31170 Negative_regulation denotes inhibitor
T25501 31228-31233 Protein denotes Stat3
T25502 31234-31244 Negative_regulation denotes inhibitors
T25503 31365-31370 Protein denotes Stat3
T25537 16951-16955 Protein denotes LMP1
T495 4-29 Protein denotes Latent Membrane Protein 1
T496 30-39 Positive_regulation denotes Activates
T497 30-39 Positive_regulation denotes Activates
T498 40-43 Protein denotes Akt
T499 55-60 Protein denotes Stat3
T500 141-166 Protein denotes Latent membrane protein 1
T501 168-172 Protein denotes LMP1
T502 248-252 Protein denotes LMP1
T503 500-510 Negative_regulation denotes inhibitors
T504 500-510 Negative_regulation denotes inhibitors
T505 514-517 Protein denotes Akt
T506 529-534 Protein denotes Stat3
T507 567-571 Protein denotes LMP1
T508 658-661 Protein denotes IL4
T509 662-667 Protein denotes Stat6
T510 744-749 Protein denotes Stat3
T511 789-800 Regulation denotes deregulated true
T512 789-800 Regulation denotes deregulated true
T513 789-800 Regulation denotes deregulated true
T514 909-912 Protein denotes Akt
T515 924-929 Protein denotes Stat3
T2974 2641-2666 Protein denotes Latent membrane protein 1
T2975 2668-2672 Protein denotes LMP1
T2976 2792-2801 Gene_expression denotes expressed
T2977 2879-2883 Protein denotes LMP1
T2978 2891-2895 Protein denotes CD40
T2979 2916-2920 Protein denotes LMP1
T18138 35620-35624 Protein denotes LMP2
T18139 35794-35798 Protein denotes LMP2
T18140 35937-35941 Protein denotes LMP2
T18141 36090-36094 Protein denotes LMP1
T18142 36164-36168 Protein denotes LMP1
T18143 36360-36364 Protein denotes CD40
T18144 37076-37080 Protein denotes LMP1
T18145 37084-37093 Gene_expression denotes expressed
T18146 37199-37207 Positive_regulation denotes elevated
T9337 20104-20112 Gene_expression denotes detected true
T9338 20104-20112 Gene_expression denotes detected true
T9339 20104-20112 Gene_expression denotes detected true
T9340 20104-20112 Gene_expression denotes detected true
T9341 20158-20161 Protein denotes L32
T9342 20222-20235 Transcription denotes Transcription
T9343 20222-20235 Transcription denotes Transcription
T9344 20222-20235 Transcription denotes Transcription
T9345 20239-20243 Protein denotes IL10
T9346 20245-20249 Protein denotes IL15
T9347 20255-20259 Protein denotes IFNγ
T9348 20290-20294 Protein denotes LMP1
T9349 20345-20351 Positive_regulation denotes higher
T9350 20345-20351 Positive_regulation denotes higher
T9351 20345-20351 Positive_regulation denotes higher
T9352 20460-20470 Gene_expression denotes expression
T9353 20460-20470 Gene_expression denotes expression
T9354 20474-20478 Protein denotes IL15
T9355 20483-20487 Protein denotes IFNγ
T9356 20496-20500 Protein denotes LMP1
T9357 20528-20542 Protein denotes lymphoma cells
T9358 20560-20572 Positive_regulation denotes upregulation
T9359 20560-20572 Positive_regulation denotes upregulation
T9360 20576-20580 Protein denotes IL15
T9361 20585-20589 Protein denotes IFNγ
T9362 20593-20600 Positive_regulation denotes induced true
T9363 20593-20600 Positive_regulation denotes induced true
T9364 20604-20608 Protein denotes LMP1
T9365 20609-20619 Gene_expression denotes expression
T9366 20710-20714 Protein denotes IL10
T9367 20757-20766 Positive_regulation denotes increased
T9368 20803-20807 Protein denotes LMP1
T9369 20846-20850 Protein denotes LMP1
T9370 20887-20897 Gene_expression denotes Production
T9371 20887-20897 Gene_expression denotes Production
T9372 20901-20905 Protein denotes IL15
T9373 20910-20914 Protein denotes IFNγ
T9374 21112-21124 Positive_regulation denotes upregulation
T9375 21128-21132 Protein denotes IL10
T9376 21164-21168 Protein denotes IL10
T9377 21169-21181 Positive_regulation denotes upregulation
T9378 21287-21291 Protein denotes LMP1
T9379 21333-21337 Protein denotes LMP1
T9380 21382-21391 Positive_regulation denotes increased
T9381 21402-21416 Phosphorylation denotes phosphorylated
T9382 21437-21446 Positive_regulation denotes activated
T9383 21447-21452 Protein denotes Stat3
T9384 21456-21462 Regulation denotes target
T9385 21470-21474 Protein denotes IL10
T9386 21554-21565 Regulation denotes correlation true
T9387 21588-21592 Protein denotes IL10
T9388 21593-21602 Positive_regulation denotes induction
T9389 21621-21626 Protein denotes Stat3
T9390 21627-21637 Positive_regulation denotes activation
T9391 21662-21672 Positive_regulation denotes activation
T9392 21676-21681 Protein denotes Stat3
T9393 21696-21703 Positive_regulation denotes induced true true
T9394 21707-21711 Protein denotes IL10
T9395 21720-21725 Protein denotes Stat3
T9396 21785-21796 Regulation denotes correlation true
T25538 16956-16966 Gene_expression denotes Transgenic
R10614 T13937 T13935 themeOf Akt,inhibitors
R10621 T13938 T13936 themeOf Stat3,inhibitors
R10622 T13939 T13934 themeOf mTOR,inhibitors
R10623 T13942 T13941 themeOf activation,inhibits
R10624 T13943 T13942 themeOf Akt,activation
R10625 T13946 T13945 themeOf Akt,activation
R10626 T13950 T13948 themeOf Akt,phosphorylated
R10627 T13951 T13949 themeOf Stat3,phosphorylated
R10628 T13954 T13953 themeOf phosphorylation,blocked
R10629 T13955 T13954 themeOf Akt,phosphorylation
R10630 T13956 T13958 themeOf phosphorylated,detected
R10631 T13957 T13956 themeOf Akt,phosphorylated
R10632 T13961 T13960 themeOf Stat3,Phosphorylated
R10633 T13962 T13959 themeOf IκBα,Phosphorylated
R10634 T13964 T13963 themeOf Akt,targets
R10635 T13965 T13966 themeOf Akt,activation
R10636 T13968 T13974 themeOf Phosphorylated,present
R10637 T13968 T13977 themeOf Phosphorylated,detected
R10638 T13969 T13973 themeOf Phosphorylated,present
R10639 T13969 T13978 themeOf Phosphorylated,detected
R10640 T13970 T13969 themeOf Akt,Phosphorylated
R10641 T13971 T13968 themeOf Stat3,Phosphorylated
R10642 T13972 T13975 themeOf IκBα,present
R10643 T13972 T13976 themeOf IκBα,detected
R10644 T13982 T13981 themeOf activation,effects
R10645 T13983 T13980 themeOf activation,effects
R10646 T13984 T13983 themeOf Akt,activation
R10647 T13985 T13982 themeOf Stat3,activation
R10648 T13987 T13986 themeOf activation,inhibits
R10649 T13988 T13987 themeOf Stat3,activation
R10650 T13991 T13990 themeOf Stat3,activated
R10651 T13995 T13993 themeOf Akt,Phosphorylated
R10652 T13995 T13999 themeOf Akt,detectable
R10653 T13995 T14003 themeOf Akt,decreased
R10654 T13996 T13994 themeOf Stat3,Phosphorylated
R10655 T13996 T13998 themeOf Stat3,detectable
R10656 T13996 T14002 themeOf Stat3,decreased
R10657 T13997 T14000 themeOf IκBα,detectable
R10658 T13997 T14001 themeOf IκBα,decreased
R10659 T14005 T14004 themeOf Stat3,inhibitor
R10660 T14008 T14009 themeOf IκBα,affected
R10661 T14011 T14010 themeOf Stat3,inhibition
R10662 T14013 T14014 themeOf Stat3,inhibition
R10663 T14020 T14019 themeOf MEK1,inhibitor
R10664 T14021 T14018 themeOf 2,inhibitor
R10665 T14027 T14026 themeOf mTOR,inhibitor
R10666 T14028 T14029 themeOf mTOR,targeted
R2354 T2974 T2976 themeOf Latent membrane protein 1,expressed
R2355 T2975 T2974 equivalentTo LMP1,Latent membrane protein 1
R2356 T2981 T2982 themeOf CD40,interacts
R2357 T2983 T2982 themeOf CD40 ligand,interacts
R2358 T2983 T2984 themeOf CD40 ligand,expressed
R2390 T3034 T3035 themeOf expressed,under the control
R2391 T3038 T3037 themeOf LMP1,express
R2392 T3042 T3041 themeOf Akt,activated
R2393 T3044 T3043 themeOf cRel,activation
R2394 T3051 T3050 themeOf activated,absence
R2395 T3052 T3051 themeOf Stat6,activated
R2396 T3052 T3054 themeOf Stat6,target
R2397 T3053 T3054 causeOf IL4,target
R2398 T3056 T3055 themeOf Stat3,activation
R2399 T3058 T3061 themeOf Akt,deregulated
R2400 T3059 T3062 themeOf Stat3,deregulated
R3115 T3973 T3974 themeOf LMP1,Expression
R3116 T3974 T3972 themeOf Expression,High Levels
R3117 T3975 T3976 themeOf LMP1,expression
R3118 T3976 T3977 themeOf expression,under the control
R3119 T3978 T3979 themeOf LMP1,expression
R3120 T3979 T3980 themeOf expression,restricted
R3121 T3981 T3982 themeOf LMP1,expression
R3122 T3984 T3985 themeOf LMP1,detectable
R3123 T3987 T3988 themeOf LMP1,expression
R3124 T3988 T3989 themeOf expression,stronger
R3125 T3991 T3990 themeOf LMP1,higher level
R3126 T3993 T3992 themeOf LMP1,expression
R3127 T3995 T3994 themeOf LMP1,detected
R3128 T3996 T3997 themeOf LMP1,expression
R3129 T3999 T3998 themeOf LMP1,strong
R3130 T4001 T4000 themeOf LMP1,weakly
R3131 T4002 T4003 themeOf LMP1,expression
R3132 T4003 T4004 themeOf expression,abundantly
R3133 T4006 T4005 themeOf LMP1,intense
R3134 T4008 T4007 themeOf LMP1,increased
R3135 T4010 T4011 themeOf LMP1,expression
R3136 T4011 T4009 themeOf expression,increase
R3137 T4012 T4013 themeOf expressing,high levels
R3138 T4014 T4012 themeOf LMP1,expressing
R3139 T4016 T4017 themeOf LMP1,expression
R3140 T4017 T4015 themeOf expression,high
R3141 T4019 T4018 themeOf levels,increased
R3142 T4020 T4019 themeOf LMP1,levels
R4285 T5366 T5367 themeOf LMP1,expression
R4286 T5386 T5385 themeOf LMP1,expression
R4857 T6242 T6243 themeOf CD40,ligation
R4858 T6249 T6250 themeOf CD40,ligation
R4859 T6250 T6248 themeOf ligation,lack
R4860 T6253 T6252 themeOf IL4,absence
R4861 T6257 T6256 themeOf IL4,absence
R4862 T6270 T6269 themeOf LMP1,expression
R4863 T6271 T6272 themeOf LMP1,expression
R4864 T6274 T6275 themeOf LMP1,negative
R4865 T6276 T6277 themeOf express,high
R4866 T6276 T6280 themeOf express,low
R4867 T6282 T6276 themeOf LMP1,express
R5515 T7151 T7152 themeOf IL4,expression
R5516 T7153 T7154 themeOf IL4,transcription
R5517 T7155 T7156 themeOf IL4,transcription
R5518 T7157 T7158 themeOf IL4,transcription
R5519 T7164 T7163 themeOf Stat6,Activated
R5520 T7164 T7166 themeOf Stat6,target
R5521 T7165 T7164 equivalentTo pStat6,Stat6
R5522 T7170 T7171 causeOf IL4,induced
R5523 T7172 T7173 themeOf Stat6,phosphorylation
R5524 T7173 T7171 themeOf phosphorylation,induced
R7188 T9342 T9349 themeOf Transcription,higher
R7189 T9316 T9317 causeOf LMP1,Upregulates
R7190 T9316 T9319 causeOf LMP1,Activates
R7191 T9318 T9317 themeOf IL10,Upregulates
R7192 T9320 T9319 themeOf Stat3,Activates
R7193 T9322 T9335 themeOf IL4,detected
R7194 T9323 T9336 themeOf IL5,detected
R7195 T9324 T9333 themeOf IL10,detected
R7196 T9343 T9351 themeOf Transcription,higher
R7197 T9325 T9332 themeOf IL13,detected
R7198 T9326 T9339 themeOf IL15,detected
R7199 T9327 T9337 themeOf IL9,detected
R7200 T9344 T9350 themeOf Transcription,higher
R7201 T9328 T9338 themeOf IL2,detected
R7202 T9329 T9340 themeOf IL6,detected
R7203 T9330 T9334 themeOf IFNγ,detected
R7204 T9345 T9344 themeOf IL10,Transcription
R7205 T9346 T9343 themeOf IL15,Transcription
R7206 T9347 T9342 themeOf IFNγ,Transcription
R7207 T9354 T9352 themeOf IL15,expression
R7208 T9372 T9371 themeOf IL15,Production
R7209 T9355 T9353 themeOf IFNγ,expression
R7210 T9373 T9370 themeOf IFNγ,Production
R7211 T9358 T9363 themeOf upregulation,induced
R7212 T9375 T9374 themeOf IL10,upregulation
R7213 T9376 T9377 themeOf IL10,upregulation
R7214 T9359 T9362 themeOf upregulation,induced
R7215 T9381 T9380 themeOf phosphorylated,increased
R7216 T9360 T9358 themeOf IL15,upregulation
R7217 T9383 T9381 themeOf Stat3,phosphorylated
R7218 T9383 T9382 themeOf Stat3,activated
R7219 T9383 T9384 themeOf Stat3,target
R7220 T9361 T9359 themeOf IFNγ,upregulation
R7221 T9387 T9388 themeOf IL10,induction
R7222 T9364 T9365 themeOf LMP1,expression
R7223 T9388 T9386 causeOf induction,correlation
R7224 T9389 T9390 themeOf Stat3,activation
R7225 T9390 T9386 themeOf activation,correlation
R7226 T9391 T9393 themeOf activation,induced
R7227 T9392 T9391 themeOf Stat3,activation
R7228 T9365 T9363 causeOf expression,induced
R7229 T9394 T9393 causeOf IL10,induced
R7230 T9365 T9362 causeOf expression,induced
R7231 T9366 T9367 themeOf IL10,increased
R7232 T9397 T9398 themeOf LMP1,expression
R7233 T9398 T9396 causeOf expression,correlation
R7234 T9399 T9400 themeOf IL10,induction
R7235 T9442 T9440 themeOf pStat3,activation
R7236 T9400 T9396 themeOf induction,correlation
R7237 T9401 T9403 themeOf induction,affected
R7238 T9402 T9401 themeOf IL10,induction
R7239 T9404 T9403 causeOf LMP1,affected
R7240 T9406 T9405 themeOf IL10,Neutralizing
R7241 T9408 T9407 themeOf Stat3,activation
R7242 T9410 T9411 themeOf pStat3,activated
R7243 T9413 T9414 causeOf IL10,enhanced
R7244 T9443 T9441 themeOf Stat3,activation
R7245 T9415 T9416 themeOf pStat3,activation
R7246 T9416 T9414 themeOf activation,enhanced
R7247 T9418 T9419 themeOf Stat3,activation
R7248 T9419 T9420 themeOf activation,enhanced
R7249 T9423 T9422 themeOf IL10,neutralizing effect
R7250 T9426 T9427 locationOf Nuclear,translocation
R7251 T9427 T9429 themeOf translocation,consequence
R7252 T9428 T9427 themeOf pStat3,translocation
R7253 T9428 T9430 themeOf pStat3,activation
R7254 T9430 T9429 causeOf activation,consequence
R7255 T9431 T9433 locationOf nuclear,detected
R7256 T9432 T9433 themeOf pStat3,detected
R7257 T9434 T9436 locationOf nuclear,detectable
R7258 T9434 T9438 locationOf nuclear,detected
R7259 T9435 T9436 themeOf pStat3,detectable
R7260 T9435 T9438 themeOf pStat3,detected
R8705 T11450 T11449 themeOf activation,requires
R8706 T11451 T11450 themeOf Akt,activation
R8707 T11453 T11452 themeOf pAkt,activated
R8708 T11460 T11459 themeOf pAkt,increased
R8709 T11463 T11462 themeOf pAkt,increase
R8710 T11464 T11465 themeOf Akt,target
R8711 T11465 T11468 themeOf target,inactivated
R8712 T11466 T11465 themeOf glycogen synthase kinase 3,target
R8713 T11467 T11466 equivalentTo GSK3,glycogen synthase kinase 3
R8714 T11470 T11469 themeOf phosphorylated,increased
R8715 T11471 T11470 themeOf GSK3,phosphorylated
R8716 T11472 T11473 themeOf GSK3,target
R8717 T11475 T11473 themeOf Akt,target
R8718 T11475 T11474 themeOf Akt,activated
R8719 T11478 T11477 themeOf Akt,activation
R8720 T11480 T11479 themeOf GSK3,phosphorylation
R8721 T11482 T11481 themeOf Akt,activated
R8722 T11484 T11483 themeOf GSK3,phosphorylated
R8723 T11486 T11485 themeOf GSK3,regulation
R8724 T11487 T11488 themeOf Akt,targets
R8725 T11490 T11492 themeOf Activated,increased
R8726 T11490 T11494 themeOf Activated,affected
R8727 T11491 T11490 themeOf p-mTOR,Activated
R8728 T11495 T11496 causeOf LMP1,induced
R8729 T11496 T11494 causeOf induced,affected
R8730 T11497 T11498 themeOf Akt,activation
R8731 T11498 T11496 themeOf activation,induced
R8732 T11502 T11501 themeOf FoxO1,targets
R8733 T11505 T11506 themeOf FoxO1,decreased
R8734 T11509 T11510 themeOf Akt,activation
R8735 T11510 T11511 causeOf activation,induce
R8736 T11512 T11513 themeOf FoxO1,degradation
R8737 T11513 T11511 themeOf degradation,induce
R8738 T11515 T11516 causeOf Akt,regulator
R8739 T11517 T11516 themeOf FoxO1,regulator
R8740 T11519 T11518 themeOf p27,expression
R8741 T11533 T11531 themeOf pRb,enhanced
R8742 T11535 T11532 themeOf Cdk2,enhanced
R8743 T11538 T11537 themeOf increased,led
R8744 T11539 T11538 themeOf Rb,increased
R8745 T11541 T11540 themeOf Cdk2,high levels
R8746 T11543 T11542 themeOf p27,decreased
R8747 T11547 T11546 themeOf FoxO1,loss
R8748 T11549 T11548 themeOf p27,decreased
R13959 T18123 T18122 themeOf expression,higher
R13960 T18124 T18123 themeOf LMP1,expression
R13965 T18131 T18132 themeOf CD40,deficient
R13967 T18136 T18135 themeOf LMP1,expression
R13970 T18144 T18145 themeOf LMP1,expressed
R13971 T18227 T18229 causeOf Repression,inhibit
R13972 T18147 T18146 themeOf expression,elevated
R13973 T18148 T18147 themeOf LMP1,expression
R13974 T18152 T18151 themeOf IL10,upregulation
R13975 T18228 T18227 themeOf FoxO1,Repression
R13976 T18230 T18229 themeOf expression,inhibit
R13977 T18157 T18156 themeOf IL10,Induction
R13978 T18158 T18159 causeOf LMP1,stimulate
R13979 T18160 T18161 themeOf IL10,expression
R13980 T18231 T18230 themeOf bcl6,expression
R13981 T18161 T18159 themeOf expression,stimulate
R13982 T18162 T18163 themeOf Stat3,activated
R13983 T18237 T18236 themeOf bcl6,downregulation
R13984 T18164 T18166 causeOf induction,enhance
R13985 T18165 T18164 themeOf IL10,induction
R13986 T18167 T18168 themeOf Stat3,activation
R13987 T18168 T18166 themeOf activation,enhance
R13988 T18238 T18243 themeOf expression,exclusive
R13989 T18238 T18243 causeOf expression,exclusive
R13990 T18238 T18242 themeOf expression,exclusive
R13991 T18176 T18175 themeOf cRel,deficient
R13992 T18238 T18244 causeOf expression,exclusive
R13993 T18177 T18174 themeOf p85,deficient
R13994 T18178 T18179 themeOf CD40,ligation
R13995 T18239 T18242 causeOf expression,exclusive
R13996 T18180 T18181 themeOf cRel,activated
R13997 T18239 T18244 themeOf expression,exclusive
R13998 T18239 T18245 themeOf expression,exclusive
R13999 T18239 T18245 causeOf expression,exclusive
R14000 T18184 T18183 themeOf cRel,activation
R14001 T18240 T18238 themeOf LMP1,expression
R14002 T18186 T18187 causeOf LMP1,induces
R14003 T18186 T18188 causeOf LMP1,induces
R14004 T18189 T18187 themeOf activation,induces
R14005 T18190 T18189 themeOf Akt,activation
R14006 T18241 T18239 themeOf bcl6,expression
R14007 T18191 T18188 themeOf activation,induces
R14008 T18192 T18191 themeOf cRel,activation
R14009 T18193 T18194 causeOf CD40,induces
R14010 T18248 T18247 themeOf Akt,activation
R14011 T18195 T18194 themeOf downregulation,induces
R14012 T18196 T18195 themeOf p27,downregulation
R14013 T18199 T18198 themeOf p27,decreased
R14014 T18201 T18200 themeOf Rb,phosphorylation
R14015 T18250 T18249 themeOf Fox01,lack
R14016 T18203 T18202 themeOf Cdk2,increased
R14017 T18250 T18254 themeOf Fox01,pathway
R14018 T18207 T18208 themeOf Akt,activation
R14019 T18251 T18254 causeOf LMP1,pathway
R14020 T18208 T18206 themeOf activation,requirement
R14021 T18209 T18210 themeOf Akt,inhibitor
R14022 T18253 T18252 themeOf bcl6,affects
R14023 T18211 T18214 causeOf activated,lead
R14024 T18211 T18213 causeOf activated,lead
R14025 T18212 T18211 themeOf pAkt,activated
R14026 T18254 T18252 causeOf pathway,affects
R14027 T18215 T18214 themeOf phosphorylation,lead
R14028 T18216 T18213 themeOf inactivation,lead
R14029 T18217 T18215 themeOf GSK3,phosphorylation
R14030 T18217 T18216 themeOf GSK3,inactivation
R14031 T18257 T18255 themeOf p27,regulation
R14032 T18221 T18220 themeOf activated,absence
R14033 T18258 T18256 themeOf CyclinD2,regulation
R14034 T18259 T18262 causeOf loss,correlated
R14035 T18222 T18221 themeOf p-mTOR,activated
R14036 T18223 T18224 causeOf Akt,target
R14037 T18260 T18261 themeOf FoxO1,expression
R14038 T18225 T18224 themeOf inhibition,target
R14039 T18261 T18259 themeOf expression,loss
R14040 T18226 T18225 themeOf Fox01,inhibition
R14041 T18263 T18262 themeOf loss,correlated
R14042 T18264 T18263 themeOf p27,loss
R14043 T18265 T18266 themeOf CyclinD2,upregulated
R14044 T18272 T18271 themeOf p27,decreased
R18439 T23644 T23643 themeOf pStat6,activated
R18911 T24273 T24274 causeOf LMP1,Upregulates
R18912 T24273 T24277 causeOf LMP1,Activates
R18913 T24275 T24276 themeOf IL10,Expression
R18914 T24276 T24274 themeOf Expression,Upregulates
R18915 T24278 T24277 themeOf Stat3,Activates
R18916 T24282 T24279 themeOf IL10,expression
R18917 T24283 T24281 themeOf IL15,expression
R18918 T24284 T24280 themeOf IFNγ,expression
R18919 T24290 T24289 themeOf pStat3,activated
R18920 T24298 T24297 themeOf pStat3,activated
R19213 T24737 T24733 themeOf pGSK3α,targets
R19214 T24737 T24736 themeOf pGSK3α,inactivated
R19215 T24738 T24734 themeOf β,targets
R369 T495 T496 causeOf Latent Membrane Protein 1,Activates
R370 T495 T497 causeOf Latent Membrane Protein 1,Activates
R371 T498 T496 themeOf Akt,Activates
R372 T499 T497 themeOf Stat3,Activates
R373 T505 T504 themeOf Akt,inhibitors
R374 T506 T503 themeOf Stat3,inhibitors
R375 T508 T513 themeOf IL4,deregulated
R376 T509 T511 themeOf Stat6,deregulated
R377 T510 T512 themeOf Stat3,deregulated
R2359 T2985 T2986 themeOf LMP1,oligomerization
R2360 T2987 T2990 themeOf LMP1,interact
R2361 T2988 T2989 themeOf CD40,interact
R2362 T2996 T2997 themeOf CD40,ligation
R2363 T3002 T3001 themeOf CD40,deficient
R2364 T3003 T3000 themeOf CD40L,deficient
R2365 T3004 T3008 themeOf membrane proximal,bind
R2366 T3004 T3006 partOf membrane proximal,CD40
R2367 T3005 T3010 themeOf distal cytoplasmic regions,bind
R2368 T3005 T3006 partOf distal cytoplasmic regions,CD40
R2369 T3005 T3009 themeOf distal cytoplasmic regions,bind
R2370 T3005 T3007 themeOf distal cytoplasmic regions,bind
R2371 T3011 T3008 themeOf TRAF6,bind
R2372 T3012 T3010 themeOf TRAFs2,bind
R2373 T3013 T3009 themeOf 3,bind
R2374 T3014 T3007 themeOf 5,bind
R2375 T3017 T3018 themeOf CD40,deficient
R2376 T3018 T3016 themeOf deficient,rescue
R2377 T3025 T3021 themeOf TRAFs 1,recruits
R2378 T3026 T3024 themeOf 2,recruits
R2379 T3027 T3023 themeOf 3,recruits
R2380 T3028 T3020 themeOf 5,recruits
R2381 T3029 T3022 themeOf TRAF6,recruits
R2382 T3030 T3021 themeOf C-terminal activation regions 1,recruits
R2383 T3030 T3019 partOf C-terminal activation regions 1,LMP1
R2384 T3030 T3024 themeOf C-terminal activation regions 1,recruits
R2385 T3030 T3023 themeOf C-terminal activation regions 1,recruits
R2386 T3030 T3020 themeOf C-terminal activation regions 1,recruits
R2387 T3031 T3022 themeOf 2 domains,recruits
R2388 T3031 T3019 partOf 2 domains,LMP1
R2389 T3033 T3034 themeOf LMP1,expressed
R17255 T22064 T22065 themeOf LMP1,Expression
R17256 T22065 T22063 themeOf Expression,High
R17257 T22066 T22067 themeOf LMP1,expression
R19216 T24738 T24735 themeOf β,inactivated
R19217 T24740 T24739 themeOf p-mTOR,activated
R19218 T24745 T24744 themeOf pRb,activated
R19552 T25200 T25198 themeOf mTOR,inhibitors
R19553 T25201 T25197 themeOf Akt,inhibitors
R19554 T25202 T25196 themeOf MEK1,inhibitors
R19555 T25203 T25195 themeOf 2,inhibitors
R19556 T25204 T25199 themeOf Stat3,inhibitors
R19765 T25499 T25500 themeOf Akt,inhibitor
R19766 T25501 T25502 themeOf Stat3,inhibitors
R19790 T25537 T25538 themeOf LMP1,Transgenic

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T472 0-29 Protein denotes EBV Latent Membrane Protein 1
T473 40-43 Protein denotes Akt
T474 45-49 Protein denotes NFκB
T475 55-60 Protein denotes Stat3
T476 30-39 Positive_regulation denotes Activates
T477 30-39 Positive_regulation denotes Activates
T478 30-39 Positive_regulation denotes Activates
T479 141-166 Protein denotes Latent membrane protein 1
T480 168-172 Protein denotes LMP1
T481 248-252 Protein denotes LMP1
T482 514-517 Protein denotes Akt
T483 519-523 Protein denotes NFκB
T484 529-534 Protein denotes Stat3
T485 567-571 Protein denotes LMP1
T486 500-510 Negative_regulation denotes inhibitors
T487 500-510 Negative_regulation denotes inhibitors
T488 500-510 Negative_regulation denotes inhibitors
T489 658-661 Protein denotes IL4
T490 662-667 Protein denotes Stat6
T491 744-749 Protein denotes Stat3
T492 909-912 Protein denotes Akt
T493 914-918 Protein denotes NFκB
T494 924-929 Protein denotes Stat3
T2872 2641-2666 Protein denotes Latent membrane protein 1
T2873 2668-2672 Protein denotes LMP1
T2874 2792-2801 Gene_expression denotes expressed
T2875 2792-2801 Gene_expression denotes expressed
T2876 2879-2883 Protein denotes LMP1
T2877 2891-2895 Protein denotes CD40
T2878 2916-2920 Protein denotes LMP1
T2879 2925-2929 Protein denotes CD40
T2880 2997-3001 Protein denotes CD40
T2881 3017-3028 Protein denotes CD40 ligand
T2882 3109-3113 Protein denotes LMP1
T2883 3002-3011 Binding denotes interacts
T2884 3029-3038 Gene_expression denotes expressed
T2885 3171-3186 Binding denotes oligomerization
T2886 3188-3192 Protein denotes LMP1
T2887 3197-3210 Protein denotes CD40 interact
T2888 3225-3274 Protein denotes tumor necrosis factor receptor–associated factors
T2889 3276-3281 Protein denotes TRAFs
T2890 3308-3312 Protein denotes NFκB
T2891 3314-3337 Protein denotes c-Jun N terminal kinase
T2892 3339-3342 Protein denotes JNK
T2893 3349-3352 Protein denotes p38
T2894 3294-3304 Positive_regulation denotes activation
T2895 3294-3304 Positive_regulation denotes activation
T2896 3294-3304 Positive_regulation denotes activation
T2897 3400-3404 Protein denotes NFκB
T2898 3386-3396 Positive_regulation denotes Activation
T2899 3542-3546 Protein denotes LMP1
T2900 3562-3591 Protein denotes phosphatidylinositol 3 kinase
T2901 3593-3597 Protein denotes PI3K
T2902 3599-3602 Protein denotes Akt
T2903 3654-3658 Protein denotes LMP1
T2904 3552-3561 Positive_regulation denotes activates
T2905 3552-3561 Positive_regulation denotes activates
T2906 3760-3764 Protein denotes CD40
T2907 3794-3797 Protein denotes IL4
T2908 3765-3773 Binding denotes ligation
T2909 3818-3822 Protein denotes CD40
T2910 3910-3914 Protein denotes CD40
T2911 3918-3923 Protein denotes CD40L
T2912 3896-3905 Negative_regulation denotes deficient
T2913 3896-3905 Negative_regulation denotes deficient
T2914 4058-4062 Protein denotes CD40
T2915 4073-4078 Protein denotes TRAF6
T2916 4047-4054 Entity denotes regions
T2917 4068-4072 Binding denotes bind
T2918 4068-4072 Binding denotes bind
T2919 4287-4291 Protein denotes LMP1
T2920 4303-4307 Protein denotes CD40
T2921 4335-4349 Protein denotes immunoglobulin
T2922 4351-4353 Protein denotes Ig
T2923 4392-4396 Protein denotes LMP1
T2924 4448-4453 Protein denotes TRAF6
T2925 4308-4317 Negative_regulation denotes deficient
T2926 4355-4360 Entity denotes class
T2927 4361-4370 Binding denotes switching
T2928 4397-4405 Binding denotes recruits
T2929 4505-4512 Entity denotes domains
T2930 4327-4334 Negative_regulation denotes restore
T2931 4537-4541 Protein denotes LMP1
T2932 4700-4704 Protein denotes LMP1
T2933 4771-4794 Protein denotes Ig heavy chain promoter
T2934 4756-4763 Regulation denotes control
T2935 4821-4841 Protein denotes LMP1 transgenic mice
T2936 4843-4849 Protein denotes IgLMP1
T2937 4859-4863 Protein denotes LMP1
T2938 5023-5027 Protein denotes LMP1
T2939 4851-4858 Gene_expression denotes express
T2940 4851-4858 Gene_expression denotes express
T2941 4851-4858 Gene_expression denotes express
T2942 5071-5075 Protein denotes LMP1
T2943 5102-5110 Protein denotes Ig genes
T2944 5130-5133 Protein denotes Akt
T2945 5135-5138 Protein denotes JNK
T2946 5140-5143 Protein denotes p38
T2947 5149-5153 Protein denotes NFκB
T2948 5187-5198 Protein denotes NFκB family
T2949 5120-5129 Positive_regulation denotes activated
T2950 5120-5129 Positive_regulation denotes activated
T2951 5120-5129 Positive_regulation denotes activated
T2952 5169-5179 Positive_regulation denotes activation
T2953 5236-5240 Protein denotes LMP1
T2954 5684-5688 Protein denotes LMP1
T2955 5792-5795 Protein denotes IL4
T2956 5815-5819 Protein denotes LMP1
T2957 5878-5881 Protein denotes IL4
T2958 5974-5979 Protein denotes Stat6
T2959 5985-5995 Protein denotes IL4 target
T2960 5964-5973 Positive_regulation denotes activated
T2961 5953-5960 Negative_regulation denotes absence
T2962 6065-6070 Protein denotes Stat3
T2963 6095-6097 Protein denotes Rb
T2964 6051-6061 Positive_regulation denotes activation
T2965 6136-6140 Protein denotes PI3K
T2966 6141-6144 Protein denotes Akt
T2967 6146-6150 Protein denotes NFκB
T2968 6156-6161 Protein denotes Stat3
T2969 6217-6221 Protein denotes LMP1
T2970 6497-6501 Protein denotes LMP1
T2971 6585-6588 Protein denotes Akt
T2972 6590-6594 Protein denotes NFκB
T2973 6600-6605 Protein denotes Stat3
T3925 6699-6703 Protein denotes LMP1
T3926 6704-6714 Gene_expression denotes Expression
T3927 6689-6695 Positive_regulation denotes Levels
T3928 6759-6763 Protein denotes LMP1
T3929 6778-6784 Protein denotes IgLMP1
T3930 6839-6862 Protein denotes Ig heavy chain promoter
T3931 6764-6774 Gene_expression denotes expression
T3932 6764-6774 Gene_expression denotes expression
T3933 6824-6831 Regulation denotes control
T3934 6824-6831 Regulation denotes control
T3935 6824-6831 Regulation denotes control
T3936 6937-6941 Protein denotes LMP1
T3937 6942-6952 Gene_expression denotes expression
T3938 7068-7072 Protein denotes LMP1
T3939 7193-7197 Protein denotes CD19
T3940 7073-7083 Gene_expression denotes expression
T3941 7286-7290 Protein denotes LMP1
T3942 7309-7313 Protein denotes LMP1
T3943 7368-7372 Protein denotes LMP1
T3944 7295-7305 Gene_expression denotes detectable
T3945 7373-7383 Gene_expression denotes expression
T3946 7388-7396 Positive_regulation denotes stronger
T3947 7529-7533 Protein denotes LMP1
T3948 7607-7611 Protein denotes LMP1
T3949 7520-7525 Positive_regulation denotes level
T3950 7593-7603 Gene_expression denotes expression
T3951 7739-7743 Protein denotes LMP1
T3952 7730-7738 Gene_expression denotes detected
T3953 7867-7871 Protein denotes LMP1
T3954 7913-7917 Protein denotes LMP1
T3955 7990-7994 Protein denotes LMP1
T3956 7872-7882 Gene_expression denotes expression
T3957 8026-8030 Protein denotes LMP1
T3958 8101-8105 Protein denotes LMP1
T3959 8031-8041 Gene_expression denotes expression
T3960 8153-8157 Protein denotes LMP1
T3961 8236-8240 Protein denotes LMP1
T3962 8307-8311 Protein denotes LMP1
T3963 8143-8152 Positive_regulation denotes increased
T3964 8241-8251 Gene_expression denotes expression
T3965 8281-8291 Gene_expression denotes expressing
T3966 8224-8232 Positive_regulation denotes increase
T3967 8343-8347 Protein denotes LMP1
T3968 8462-8466 Protein denotes LMP1
T3969 8348-8358 Gene_expression denotes expression
T3970 8442-8451 Positive_regulation denotes increased
T3971 8338-8342 Positive_regulation denotes high
T5326 9020-9024 Protein denotes LMP1
T5327 9058-9082 Protein denotes Escape Allelic Exclusion
T5328 9099-9103 Protein denotes LMP1
T5329 9198-9202 Protein denotes LMP1
T5330 9215-9252 Protein denotes surface Ig expression of heavy chains
T5331 9254-9257 Protein denotes IgM
T5332 9259-9262 Protein denotes IgG
T5333 9264-9267 Protein denotes IgD
T5334 9203-9213 Gene_expression denotes expression
T5335 9360-9363 Protein denotes IgG
T5336 9455-9459 Protein denotes LMP1
T5337 9493-9497 Protein denotes LMP1
T5338 9621-9625 Protein denotes LMP1
T5339 9786-9790 Protein denotes CD5+
T5340 9792-9796 Protein denotes B-1a
T5341 9911-9926 Protein denotes B-1a marker CD5
T5342 9952-9956 Protein denotes LMP1
T5343 10323-10327 Protein denotes LMP1
T5344 10405-10417 Protein denotes splenic B-1a
T5345 10419-10423 Protein denotes CD19
T5346 10424-10427 Protein denotes CD5
T5347 10459-10463 Protein denotes CD19
T5348 10464-10467 Protein denotes CD5
T5349 10487-10491 Protein denotes LMP1
T5350 11628-11651 Protein denotes one heavy chain isotype
T5351 11653-11656 Protein denotes IgG
T5352 11658-11661 Protein denotes IgE
T5353 11666-11669 Protein denotes IgA
T5354 11615-11622 Gene_expression denotes express
T5355 11615-11622 Gene_expression denotes express
T5356 11615-11622 Gene_expression denotes express
T5357 11615-11622 Gene_expression denotes express
T5358 11889-11893 Protein denotes LMP1
T5359 11965-11979 Protein denotes Ig heavy chain
T5360 12526-12530 Protein denotes LMP1
T5361 12816-12820 Protein denotes B-1a
T5362 12931-12935 Protein denotes LMP1
T5363 12917-12927 Gene_expression denotes expression
T6191 13052-13056 Protein denotes LMP1
T6192 13159-13163 Protein denotes CD40
T6193 13164-13172 Binding denotes ligation
T6194 13231-13235 Protein denotes LMP1
T6195 13343-13346 Protein denotes IL4
T6196 13620-13623 Protein denotes IL4
T6197 13641-13645 Protein denotes CD40
T6198 13646-13654 Binding denotes ligation
T6199 13633-13637 Negative_regulation denotes lack
T6200 13681-13685 Protein denotes LMP1
T6201 13746-13749 Protein denotes IL4
T6202 13795-13798 Protein denotes IL4
T6203 13769-13777 Positive_regulation denotes enhanced
T6204 13814-13818 Protein denotes LMP1
T6205 13864-13867 Protein denotes MTS
T6206 13921-13925 Protein denotes LMP1
T6207 15289-15293 Protein denotes CD19
T6208 15295-15302 Protein denotes gated B
T6209 15345-15349 Protein denotes LMP1
T6210 15414-15418 Protein denotes LMP1
T6211 15493-15497 Protein denotes LMP1
T6212 15651-15654 Protein denotes IL4
T6213 15727-15731 Protein denotes LMP1
T6214 15777-15780 Protein denotes IL4
T6215 15876-15879 Protein denotes IL4
T6216 15942-15946 Protein denotes LMP1
T6217 15880-15891 Positive_regulation denotes requirement
T6218 15997-16001 Protein denotes LMP1
T6219 16063-16067 Protein denotes BrdU
T6220 16096-16100 Protein denotes LMP1
T6221 15983-15993 Gene_expression denotes expression
T6222 16101-16111 Gene_expression denotes expression
T6223 16237-16241 Protein denotes BrdU
T6224 16311-16315 Protein denotes LMP1
T6225 16443-16447 Protein denotes LMP1
T6226 16448-16456 Gene_expression denotes negative
T6227 16579-16583 Protein denotes LMP1
T6228 16584-16586 Protein denotes L2
T6229 16618-16625 Protein denotes LMP1-L5
T6230 16637-16641 Protein denotes LMP1
T6231 16681-16685 Protein denotes LMP1
T6232 16551-16558 Gene_expression denotes express
T6233 16551-16558 Gene_expression denotes express
T6234 16551-16558 Gene_expression denotes express
T6235 16564-16568 Positive_regulation denotes high
T6236 16564-16568 Positive_regulation denotes high
T6237 16564-16568 Positive_regulation denotes high
T6238 16564-16568 Positive_regulation denotes high
T6239 16794-16797 Protein denotes IL4
T6240 16823-16826 Protein denotes IL4
T7108 17038-17041 Protein denotes IL4
T7109 17046-17051 Protein denotes Stat6
T7110 17085-17088 Protein denotes IL4
T7111 17124-17127 Protein denotes IL4
T7112 17140-17143 Protein denotes IL4
T7113 17177-17182 Protein denotes Rnase
T7114 17128-17138 Gene_expression denotes expression
T7115 17144-17157 Transcription denotes transcription
T7116 17207-17210 Protein denotes IL4
T7117 17211-17224 Transcription denotes transcription
T7118 17328-17331 Protein denotes IL4
T7119 17368-17372 Protein denotes CD19
T7120 17374-17378 Protein denotes MACS
T7121 17443-17447 Protein denotes LMP1
T7122 17504-17509 Protein denotes GAPDH
T7123 17514-17517 Protein denotes L32
T7124 17332-17345 Transcription denotes transcription
T7125 17577-17582 Protein denotes Stat6
T7126 17584-17590 Protein denotes pStat6
T7127 17609-17621 Protein denotes IL4 receptor
T7128 17665-17669 Protein denotes LMP1
T7129 17567-17576 Positive_regulation denotes Activated
T7130 17567-17576 Positive_regulation denotes Activated
T7131 17719-17725 Protein denotes pStat6
T7132 17773-17777 Protein denotes LMP1
T7133 17884-17887 Protein denotes IL4
T7134 17896-17901 Protein denotes Stat6
T7135 17902-17917 Phosphorylation denotes phosphorylation
T7136 17888-17895 Positive_regulation denotes induced
T7137 19044-19047 Protein denotes IL4
T7138 19288-19291 Protein denotes IL4
T7139 19357-19360 Protein denotes IL4
T7140 19419-19422 Protein denotes IL4
T7141 19442-19445 Protein denotes MTS
T7142 19458-19462 Protein denotes LMP1
T7143 19431-19437 Regulation denotes affect
T7144 19532-19536 Protein denotes LMP1
T7145 19585-19588 Protein denotes IL4
T7146 19619-19624 Protein denotes Stat6
T9257 21447-21452 Protein denotes Stat3
T9258 21470-21483 Protein denotes IL10 receptor
T9259 21392-21398 Gene_expression denotes levels
T9260 21392-21398 Gene_expression denotes levels
T9261 21437-21446 Positive_regulation denotes activated
T9262 21456-21462 Positive_regulation denotes target
T9263 21382-21391 Positive_regulation denotes increased
T9264 21382-21391 Positive_regulation denotes increased
T9265 21588-21592 Protein denotes IL10
T9266 21621-21626 Protein denotes Stat3
T9267 21593-21602 Positive_regulation denotes induction
T9268 21627-21637 Positive_regulation denotes activation
T9269 21676-21681 Protein denotes Stat3
T9270 21707-21711 Protein denotes IL10
T9271 21720-21725 Protein denotes Stat3
T9272 21662-21672 Positive_regulation denotes activation
T9273 21696-21703 Positive_regulation denotes induced
T9274 21726-21736 Positive_regulation denotes activation
T9275 21819-21823 Protein denotes LMP1
T9276 21853-21857 Protein denotes IL10
T9277 21824-21834 Gene_expression denotes expression
T9278 21858-21867 Positive_regulation denotes induction
T9279 21926-21930 Protein denotes IL10
T9280 22026-22030 Protein denotes LMP1
T9281 21913-21922 Positive_regulation denotes induction
T9282 22014-22022 Regulation denotes affected
T9283 22059-22063 Protein denotes IL10
T9284 22199-22204 Protein denotes Stat3
T9285 22185-22195 Positive_regulation denotes activation
T9286 22277-22286 Protein denotes anti-IL10
T9287 22312-22318 Protein denotes pStat3
T9288 22391-22395 Protein denotes LMP1
T9289 22335-22344 Positive_regulation denotes activated
T9290 22452-22456 Protein denotes IL10
T9291 22466-22472 Protein denotes pStat3
T9292 22560-22564 Protein denotes IL10
T9293 22473-22483 Positive_regulation denotes activation
T9294 22457-22465 Positive_regulation denotes enhanced
T9295 22650-22655 Protein denotes Stat3
T9296 22698-22702 Protein denotes IL10
T9297 22656-22666 Positive_regulation denotes activation
T9298 22703-22712 Positive_regulation denotes induction
T9299 22686-22694 Positive_regulation denotes enhanced
T9300 22745-22763 Protein denotes anti-IL10 antibody
T9301 22799-22803 Protein denotes IL10
T9302 22809-22827 Protein denotes anti-IL10 antibody
T9303 22842-22858 Protein denotes rat IgG1 isotype
T9304 23941-23947 Protein denotes pStat3
T9305 23916-23923 Entity denotes Nuclear
T9306 23924-23937 Localization denotes translocation
T9307 23984-23991 Entity denotes nuclear
T9308 24129-24133 Protein denotes LMP1
T9309 24213-24217 Protein denotes LMP1
T9310 24283-24289 Protein denotes pStat3
T9311 24311-24316 Protein denotes Stat3
T9312 24331-24336 Protein denotes Stat3
T9313 24362-24366 Protein denotes LMP1
T9314 24269-24279 Positive_regulation denotes activation
T9315 24269-24279 Positive_regulation denotes activation
T11345 24399-24403 Protein denotes LMP1
T11346 24414-24417 Protein denotes Akt
T11347 24448-24461 Protein denotes Rb Cell Cycle
T11348 24404-24413 Positive_regulation denotes Activates
T11349 24470-24474 Protein denotes LMP1
T11350 24535-24539 Protein denotes PI3K
T11351 24544-24551 Protein denotes Akt [5]
T11352 24521-24531 Positive_regulation denotes activation
T11353 24512-24520 Positive_regulation denotes requires
T11354 24577-24581 Protein denotes pAkt
T11355 24567-24576 Positive_regulation denotes activated
T11356 24693-24696 Protein denotes Akt
T11357 24723-24727 Protein denotes LMP1
T11358 24812-24830 Protein denotes splenic CD19+ MACS
T11359 24849-24853 Protein denotes LMP1
T11360 24978-24982 Protein denotes LMP1
T11361 25046-25050 Protein denotes pAkt
T11362 25037-25045 Positive_regulation denotes increase
T11363 25063-25100 Protein denotes Akt target glycogen synthase kinase 3
T11364 25102-25106 Protein denotes GSK3
T11365 25177-25181 Protein denotes GSK3
T11366 25111-25122 Negative_regulation denotes inactivated
T11367 25111-25122 Negative_regulation denotes inactivated
T11368 25162-25176 Phosphorylation denotes phosphorylated
T11369 25152-25161 Positive_regulation denotes increased
T11370 25316-25320 Protein denotes GSK3
T11371 25350-25353 Protein denotes Akt
T11372 25361-25365 Protein denotes LMP1
T11373 25330-25336 Binding denotes target
T11374 25340-25349 Positive_regulation denotes activated
T11375 25434-25437 Protein denotes Akt
T11376 25465-25469 Protein denotes GSK3
T11377 25420-25430 Positive_regulation denotes activation
T11378 25446-25461 Phosphorylation denotes phosphorylation
T11379 25420-25430 Positive_regulation denotes activation
T11380 25577-25580 Protein denotes Akt
T11381 25620-25624 Protein denotes GSK3
T11382 25567-25576 Positive_regulation denotes activated
T11383 25605-25619 Phosphorylation denotes phosphorylated
T11384 25707-25711 Protein denotes GSK3
T11385 25693-25703 Regulation denotes regulation
T11386 26469-26485 Protein denotes Activated p-mTOR
T11387 26507-26511 Protein denotes LMP1
T11388 26602-26606 Protein denotes LMP1
T11389 26615-26618 Protein denotes Akt
T11390 26494-26503 Positive_regulation denotes increased
T11391 26691-26694 Protein denotes Akt
T11392 26998-27003 Protein denotes FoxO1
T11393 27008-27019 Protein_catabolism denotes degradation
T11394 26990-26997 Regulation denotes targets
T11395 27043-27048 Protein denotes FoxO1
T11396 27084-27089 Protein denotes FoxO1
T11397 27028-27039 Protein_catabolism denotes degradation
T11398 27139-27144 Protein denotes FoxO1
T11399 27192-27196 Protein denotes LMP1
T11400 27265-27273 Protein denotes Forkhead
T11401 27318-27321 Protein denotes Akt
T11402 27165-27174 Negative_regulation denotes decreased
T11403 27247-27257 Negative_regulation denotes inhibition
T11404 27308-27314 Positive_regulation denotes target
T11405 27373-27376 Protein denotes Akt
T11406 27403-27408 Protein denotes FoxO1
T11407 27424-27428 Protein denotes LMP1
T11408 27449-27452 Protein denotes Akt
T11409 27486-27491 Protein denotes FoxO1
T11410 27377-27387 Positive_regulation denotes activation
T11411 27409-27420 Negative_regulation denotes degradation
T11412 27473-27482 Regulation denotes regulator
T11413 27582-27622 Protein denotes Forkhead family of transcription factors
T11414 27664-27667 Protein denotes Cdk
T11415 27646-27656 Gene_expression denotes expression
T11416 27691-27695 Protein denotes LMP1
T11417 27756-27759 Protein denotes p27
T11418 27777-27781 Protein denotes Cdk2
T11419 27742-27752 Gene_expression denotes expression
T11420 27761-27773 Positive_regulation denotes upregulation
T11421 27892-27896 Protein denotes LMP1
T11422 27940-27942 Protein denotes Rb
T11423 27987-27990 Protein denotes pRb
T11424 27992-27996 Protein denotes Cdk2
T11425 28002-28005 Protein denotes p27
T11426 28024-28042 Protein denotes splenic CD19+ MACS
T11427 28061-28065 Protein denotes LMP1
T11428 28108-28111 Protein denotes pRb
T11429 28152-28154 Protein denotes Rb
T11430 28166-28170 Protein denotes Cdk2
T11431 28089-28097 Positive_regulation denotes enhanced
T11432 28089-28097 Positive_regulation denotes enhanced
T11433 28266-28270 Protein denotes LMP1
T11434 28324-28326 Protein denotes Rb
T11435 28359-28363 Protein denotes Cdk2
T11436 28389-28392 Protein denotes p27
T11437 28304-28313 Positive_regulation denotes increased
T11438 28369-28378 Negative_regulation denotes decreased
T11439 28435-28437 Protein denotes Rb
T11440 28464-28468 Protein denotes LMP1
T11441 28565-28568 Protein denotes p27
T11442 28537-28541 Negative_regulation denotes loss
T11443 28555-28564 Negative_regulation denotes decreased
T11444 28537-28541 Negative_regulation denotes loss
T13802 28571-28575 Protein denotes LMP1
T13803 28633-28636 Protein denotes Akt
T13804 28638-28642 Protein denotes NFκB
T13805 28648-28653 Protein denotes Stat3
T13806 28619-28629 Positive_regulation denotes Activation
T13807 28619-28629 Positive_regulation denotes Activation
T13808 28619-28629 Positive_regulation denotes Activation
T13809 28743-28747 Protein denotes LMP1
T13810 28798-28802 Protein denotes LMP1
T13811 28867-28870 Protein denotes Akt
T13812 28872-28876 Protein denotes NFκB
T13813 28878-28883 Protein denotes Stat3
T13814 28885-28889 Protein denotes mTOR
T13815 28894-28898 Protein denotes MAPK
T13816 28852-28862 Negative_regulation denotes inhibitors
T13817 28852-28862 Negative_regulation denotes inhibitors
T13818 28852-28862 Negative_regulation denotes inhibitors
T13819 28852-28862 Negative_regulation denotes inhibitors
T13820 28852-28862 Negative_regulation denotes inhibitors
T13821 29103-29107 Protein denotes LMP1
T13822 29186-29212 Protein denotes BAY11–7085, cucurbitacin I
T13823 29346-29349 Protein denotes Akt
T13824 29432-29435 Protein denotes Akt
T13825 29332-29342 Positive_regulation denotes activation
T13826 29319-29327 Negative_regulation denotes inhibits
T13827 29597-29600 Protein denotes Akt
T13828 29644-29648 Protein denotes LMP1
T13907 33076-33084 Positive_regulation denotes activate
T13908 33076-33084 Positive_regulation denotes activate
T13909 33076-33084 Positive_regulation denotes activate
T13910 33213-33222 Negative_regulation denotes inhibitor
T13911 33254-33263 Negative_regulation denotes inhibitor
T13912 33419-33427 Protein denotes p38 MAPK
T13913 33491-33495 Protein denotes LMP1
T13914 33583-33587 Protein denotes LMP1
T13915 33770-33773 Protein denotes Akt
T13916 33775-33779 Protein denotes NFκB
T13917 33785-33790 Protein denotes Stat3
T13918 33799-33803 Protein denotes MAPK
T13919 33913-33917 Protein denotes mTOR
T13920 34013-34017 Protein denotes mTOR
T13921 34037-34040 Protein denotes Akt
T13922 34055-34059 Protein denotes LMP1
T13923 33756-33766 Positive_regulation denotes activation
T13924 33756-33766 Positive_regulation denotes activation
T13925 33756-33766 Positive_regulation denotes activation
T13926 33756-33766 Positive_regulation denotes activation
T13927 33900-33909 Negative_regulation denotes inhibitor
T13928 34025-34033 Regulation denotes targeted
T17951 34182-34186 Protein denotes LMP1
T17952 34224-34228 Protein denotes LMP1
T17953 34362-34366 Protein denotes LMP1
T17954 34403-34407 Protein denotes LMP1
T17955 34341-34351 Gene_expression denotes expression
T17956 34548-34552 Protein denotes LMP1
T17957 34660-34664 Protein denotes LMP1
T17958 34758-34762 Protein denotes LMP1
T17959 34863-34867 Protein denotes LMP1
T17960 35010-35014 Protein denotes LMP1
T17961 35076-35080 Protein denotes CD40
T17962 35226-35230 Protein denotes CD40
T17963 35244-35248 Protein denotes LMP1
T17964 35081-35090 Negative_regulation denotes deficient
T17965 35347-35351 Protein denotes LMP1
T17966 35333-35343 Gene_expression denotes expression
T17967 35556-35560 Protein denotes LMP1
T17968 35620-35624 Protein denotes LMP2
T17969 35765-35780 Protein denotes B cell receptor
T17970 35794-35798 Protein denotes LMP2
T17971 35937-35941 Protein denotes LMP2
T17972 36090-36094 Protein denotes LMP1
T17973 36360-36364 Protein denotes CD40
T17974 36609-36612 Protein denotes IgM
T17975 36617-36631 Protein denotes IgA antibodies
T17976 36582-36589 Gene_expression denotes produce
T17977 36599-36605 Gene_expression denotes source
T17978 36599-36605 Gene_expression denotes source
T17979 37076-37080 Protein denotes LMP1
T17980 37084-37093 Gene_expression denotes expressed
T17981 37222-37226 Protein denotes LMP1
T17982 37208-37218 Gene_expression denotes expression
T17983 37199-37207 Positive_regulation denotes elevated
T17984 37518-37522 Protein denotes LMP1
T17985 37636-37639 Protein denotes EBV
T17986 37644-37648 Protein denotes LMP1
T17987 37848-37852 Protein denotes IL10
T17988 37881-37886 Protein denotes Stat3
T17989 37934-37937 Protein denotes Akt
T17990 37939-37943 Protein denotes NFκB
T17991 37949-37954 Protein denotes Stat3
T17992 37832-37844 Positive_regulation denotes upregulation
T17993 37920-37930 Positive_regulation denotes activation
T17994 37920-37930 Positive_regulation denotes activation
T17995 37920-37930 Positive_regulation denotes activation
T17996 37904-37915 Positive_regulation denotes requirement
T17997 37904-37915 Positive_regulation denotes requirement
T17998 37904-37915 Positive_regulation denotes requirement
T17999 37996-38000 Protein denotes IL10
T18000 37983-37992 Positive_regulation denotes Induction
T18001 38194-38198 Protein denotes LMP1
T18002 38227-38231 Protein denotes IL10
T18003 38232-38242 Gene_expression denotes expression
T18004 38217-38226 Positive_regulation denotes stimulate
T18005 38311-38316 Protein denotes Stat3
T18006 38385-38389 Protein denotes IL10
T18007 38410-38415 Protein denotes Stat3
T18008 38335-38344 Positive_regulation denotes activated
T18009 38372-38381 Positive_regulation denotes induction
T18010 38416-38426 Positive_regulation denotes activation
T18011 38402-38409 Positive_regulation denotes enhance
T18012 38490-38494 Protein denotes LMP1
T18013 38554-38558 Protein denotes NFκB
T18014 38599-38603 Protein denotes NFκB
T18015 38628-38632 Protein denotes LMP1
T18016 38660-38664 Protein denotes LMP1
T18017 38585-38595 Negative_regulation denotes inhibition
T18018 38704-38708 Protein denotes NFκB
T18019 38713-38717 Protein denotes PI3K
T18020 38744-38748 Protein denotes CD40
T18021 38795-38799 Protein denotes cRel
T18022 38807-38829 Protein denotes p85 regulatory subunit
T18023 38833-38837 Protein denotes PI3K
T18024 38887-38891 Protein denotes CD40
T18025 38781-38790 Negative_regulation denotes deficient
T18026 38781-38790 Negative_regulation denotes deficient
T18027 38781-38790 Negative_regulation denotes deficient
T18028 38892-38900 Binding denotes ligation
T18029 38940-38944 Protein denotes cRel
T18030 38993-38997 Protein denotes LMP1
T18031 39050-39054 Protein denotes cRel
T18032 38961-38970 Positive_regulation denotes activated
T18033 39036-39046 Positive_regulation denotes activation
T18034 39143-39147 Protein denotes CD40
T18035 39171-39175 Protein denotes LMP1
T18036 39206-39210 Protein denotes PI3K
T18037 39234-39237 Protein denotes Akt
T18038 39256-39260 Protein denotes NFκB
T18039 39280-39284 Protein denotes cRel
T18040 39220-39230 Positive_regulation denotes activation
T18041 39242-39252 Positive_regulation denotes activation
T18042 39242-39252 Positive_regulation denotes activation
T18043 39286-39290 Protein denotes CD40
T18044 39347-39350 Protein denotes p27
T18045 39361-39365 Protein denotes PI3K
T18046 39392-39405 Protein denotes LMP1 lymphoma
T18047 39441-39444 Protein denotes p27
T18048 39469-39471 Protein denotes Rb
T18052 39450-39465 Phosphorylation denotes phosphorylation
T18053 39450-39465 Phosphorylation denotes phosphorylation
T18054 39476-39485 Positive_regulation denotes increased
T18055 39296-39303 Positive_regulation denotes induces
T18056 39518-39522 Protein denotes LMP1
T18057 39556-39558 Protein denotes Rb
T18058 39697-39700 Protein denotes Akt
T18059 39794-39797 Protein denotes Akt
T18060 39701-39711 Positive_regulation denotes activation
T18061 39798-39807 Negative_regulation denotes inhibitor
T18062 39681-39692 Positive_regulation denotes requirement
T18063 39832-39836 Protein denotes pAkt
T18064 39911-39915 Protein denotes GSK3
T18065 39822-39831 Positive_regulation denotes activated
T18066 39845-39849 Positive_regulation denotes lead
T18067 39853-39868 Phosphorylation denotes phosphorylation
T18068 39873-39885 Negative_regulation denotes inactivation
T18069 40074-40078 Protein denotes LMP1
T18070 40123-40127 Protein denotes LMP1
T18071 40404-40431 Protein denotes Fox01 transcription factors
T18072 40386-40396 Negative_regulation denotes inhibition
T18073 40365-40371 Regulation denotes target
T18074 40486-40491 Protein denotes FoxO1
T18075 40497-40501 Protein denotes PI3K
T18076 40545-40549 Protein denotes bcl6
T18077 40433-40443 Negative_regulation denotes Repression
T18078 40531-40541 Gene_expression denotes expression
T18079 40523-40530 Negative_regulation denotes inhibit
T18080 40652-40656 Protein denotes CD40
T18081 40750-40754 Protein denotes CD40
T18082 40861-40865 Protein denotes LMP1
T18083 40919-40923 Protein denotes bcl6
T18084 40901-40915 Negative_regulation denotes downregulation
T18085 40985-40989 Protein denotes LMP1
T18086 40994-40998 Protein denotes bcl6
T18087 40971-40981 Gene_expression denotes expression
T18088 40971-40981 Gene_expression denotes expression
T18089 41068-41072 Protein denotes LMP1
T18090 41155-41158 Protein denotes Akt
T18091 41175-41180 Protein denotes Fox01
T18092 41216-41220 Protein denotes LMP1
T18093 41354-41357 Protein denotes p27
T18094 41362-41370 Protein denotes CyclinD2
T18095 41141-41151 Positive_regulation denotes activation
T18096 41167-41171 Negative_regulation denotes lack
T18097 41273-41283 Regulation denotes regulation
T18098 41273-41283 Regulation denotes regulation
T18099 41435-41440 Protein denotes FoxO1
T18100 41441-41451 Gene_expression denotes expression
T18101 41427-41431 Negative_regulation denotes loss
T18102 41520-41528 Protein denotes CyclinD2
T18103 41570-41574 Protein denotes LMP1
T18104 41555-41566 Positive_regulation denotes upregulated
T18105 41683-41687 Protein denotes LMP1
T18106 41856-41861 Protein denotes Stat3
T18107 41883-41886 Protein denotes p27
T18108 41902-41905 Protein denotes Akt
T18109 41910-41914 Protein denotes NFκB
T18110 41873-41882 Negative_regulation denotes decreased
T18111 41892-41901 Positive_regulation denotes activated
T18112 42026-42029 Protein denotes Akt
T18113 42031-42035 Protein denotes NFκB
T18114 42041-42046 Protein denotes Stat3
T18115 42252-42256 Protein denotes NFκB
T18116 42301-42305 Protein denotes LMP1
T18117 42238-42248 Positive_regulation denotes activation
T18118 42229-42237 Positive_regulation denotes requires
T18119 42468-42472 Protein denotes LMP1
T19008 43694-43697 Protein denotes PBS
T20030 46615-46618 Protein denotes NBT
T20031 46666-46673 Protein denotes Phospho
T20032 46674-46679 Protein denotes Stat3
T20033 46709-46715 Protein denotes pStat3
T20318 46882-46910 Protein denotes appropriate primary antibody
T20319 47005-47009 Protein denotes BrdU
T20320 47010-47019 Gene_expression denotes detection
T20321 47267-47274 Protein denotes saponin
T20322 47286-47290 Protein denotes BrdU
T20323 47325-47330 Protein denotes Dnase
T20324 47369-47373 Protein denotes BrdU
T20752 47543-47548 Protein denotes Rnase
T20753 47595-47599 Protein denotes CD19
T20754 47601-47605 Protein denotes MACS
T20755 47667-47672 Protein denotes Dnase
T20756 47743-47748 Protein denotes mCK-1
T20757 47915-47930 Protein denotes mCK-1 probe set
T20758 47965-47982 Protein denotes T7 RNA polymerase
T20759 48033-48037 Protein denotes Spin
T20760 48343-48348 Protein denotes Rnase
T21018 48627-48648 Protein denotes κ chain rearrangement
T21019 48727-48732 Protein denotes Rnase
T21020 48835-48853 Protein denotes Taq DNA polymerase
T21021 48855-48858 Protein denotes NEB
T21022 48928-48934 Protein denotes Jκ5–1°
T21381 49389-49415 Protein denotes 1:100 protease/phosphatase
T21382 49619-49622 Protein denotes Rad
T21383 49920-49942 Protein denotes horseradish peroxidase
T21736 50109-50112 Protein denotes IgM
T21737 50114-50139 Protein denotes rat IgG2aκ anti-mouse IgD
T21738 50155-50181 Protein denotes rat IgG1κ anti-mouse kappa
T21739 50197-50207 Protein denotes rat IgG2bκ
T21740 50271-50274 Protein denotes IgG
T21741 50372-50413 Protein denotes APC-conjugated rat IgG2aκ anti-mouse CD19
T21742 50441-50458 Protein denotes mouse IgG2aκ anti
T21743 50459-50463 Protein denotes LMP1
T21744 50497-50502 Protein denotes IgG2a
T21745 50531-50535 Protein denotes Cdk2
T21746 50600-50621 Protein denotes IgG2aκ anti-mouse CD5
T21747 50669-50682 Protein denotes Rat anti-LMP1
T21748 50772-50785 Protein denotes anti-pGSK3α/β
T21749 50863-50873 Protein denotes anti-Stat6
T21750 50875-50883 Protein denotes anti-Akt
T21751 50885-50895 Protein denotes anti-FoxO1
T21752 50906-50909 Protein denotes p27
T21753 50946-50963 Protein denotes Rabbit anti-Stat3
T21754 50973-50982 Protein denotes anti-IκBα
T21755 50995-51012 Protein denotes goat anti-β actin
T21756 51066-51082 Protein denotes Mouse IgG1κ anti
T21757 51083-51087 Protein denotes GSK3
T23613 18011-18014 Protein denotes IL4
T23614 18015-18020 Protein denotes Stat6
T23615 18046-18051 Protein denotes Rnase
T23616 18073-18081 Protein denotes IL4 mRNA
T23617 18105-18109 Protein denotes CD19
T23618 18117-18119 Protein denotes WT
T23619 18124-18128 Protein denotes LMP1
T23620 18157-18160 Protein denotes L32
T23621 18165-18170 Protein denotes GAPDH
T23622 18308-18310 Protein denotes WT
T23623 18315-18319 Protein denotes LMP1
T23624 18350-18356 Protein denotes pStat6
T23625 18382-18386 Protein denotes CD19
T23626 18465-18468 Protein denotes IL4
T23627 18340-18349 Positive_regulation denotes activated
T23628 18474-18479 Protein denotes Actin
T23629 18636-18640 Protein denotes LMP1
T23630 18681-18684 Protein denotes IL4
T23631 18713-18716 Protein denotes IL4
T23632 18727-18738 Protein denotes IgG isotype
T23633 18807-18811 Protein denotes LMP1
T24242 22890-22894 Protein denotes LMP1
T24243 22907-22911 Protein denotes IL10
T24244 22912-22922 Gene_expression denotes Expression
T24245 22895-22906 Positive_regulation denotes Upregulates
T24246 22985-22989 Protein denotes IL10
T24247 22991-22995 Protein denotes IL15
T24248 23001-23010 Protein denotes IFNγ mRNA
T24249 23014-23016 Protein denotes WT
T24250 23021-23025 Protein denotes LMP1
T24251 23046-23050 Protein denotes CD19
T24252 23074-23079 Protein denotes Rnase
T24253 22971-22981 Gene_expression denotes expression
T24254 22971-22981 Gene_expression denotes expression
T24255 22971-22981 Gene_expression denotes expression
T24256 23273-23281 Protein denotes gene L32
T24257 23401-23407 Protein denotes pStat3
T24258 23429-23433 Protein denotes CD19
T24259 23441-23443 Protein denotes WT
T24260 23448-23452 Protein denotes LMP1
T24261 23539-23543 Protein denotes IL10
T24262 23572-23576 Protein denotes IL10
T24263 23583-23599 Protein denotes rat IgG1 isotype
T24264 23391-23400 Positive_regulation denotes activated
T24265 23600-23607 Regulation denotes control
T24266 23639-23652 Protein denotes WT lymphoma 1
T24267 23657-23661 Protein denotes LMP1
T24268 23742-23747 Protein denotes Stat3
T24269 23749-23754 Protein denotes Actin
T24270 23824-23848 Protein denotes activated nuclear pStat3
T24271 23867-23869 Protein denotes WT
T24272 23874-23878 Protein denotes LMP1
T24706 25772-25785 Protein denotes Rb Cell Cycle
T24707 25728-25737 Positive_regulation denotes Activates
T24708 25845-25849 Protein denotes CD19
T24709 25872-25874 Protein denotes WT
T24710 25879-25883 Protein denotes LMP1
T24711 25904-25907 Protein denotes Akt
T24712 25945-25949 Protein denotes pAkt
T24713 25996-26004 Protein denotes pGSK3α/β
T24714 26052-26057 Protein denotes FoxO1
T24715 25935-25944 Positive_regulation denotes activated
T24716 25984-25995 Positive_regulation denotes inactivated
T24717 26112-26116 Protein denotes GSK3
T24718 26252-26254 Protein denotes Rb
T24719 26286-26289 Protein denotes pRb
T24720 26311-26315 Protein denotes Cdk2
T24721 26324-26327 Protein denotes Cdk
T24722 26338-26341 Protein denotes p27
T24723 26237-26247 Regulation denotes regulating
T24724 26276-26285 Positive_regulation denotes activated
T24725 26343-26348 Protein denotes Actin
T25173 30201-30204 Protein denotes Akt
T25174 30206-30210 Protein denotes NFκB
T25175 30216-30221 Protein denotes Stat3
T25176 30387-30391 Protein denotes LMP1
T25177 30472-30476 Protein denotes NFκB
T25178 30478-30483 Protein denotes BAY11
T25179 30486-30490 Protein denotes mTOR
T25180 30492-30501 Protein denotes rapamycin
T25181 30539-30542 Protein denotes p38
T25182 30544-30552 Protein denotes SB202190
T25183 30458-30468 Negative_regulation denotes inhibitors
T25184 30458-30468 Negative_regulation denotes inhibitors
T25185 30458-30468 Negative_regulation denotes inhibitors
T25186 30458-30468 Negative_regulation denotes inhibitors
T25187 30458-30468 Negative_regulation denotes inhibitors
T25188 30458-30468 Negative_regulation denotes inhibitors
T25189 30796-30800 Protein denotes LMP1
T25190 30859-30863 Protein denotes LMP1
T25479 30934-30937 Protein denotes Akt
T25480 30939-30943 Protein denotes NFκB
T25481 30949-30954 Protein denotes Stat3
T25482 31068-31072 Protein denotes LMP1
T25483 31098-31101 Protein denotes Akt
T25484 31103-31107 Protein denotes NFκB
T25485 31113-31118 Protein denotes Stat3
T25486 31157-31160 Protein denotes Akt
T25487 31192-31196 Protein denotes NFκB
T25488 31228-31233 Protein denotes Stat3
T25489 31161-31170 Negative_regulation denotes inhibitor
T25490 31197-31206 Negative_regulation denotes inhibitor
T25491 31234-31244 Negative_regulation denotes inhibitors
T25492 31365-31370 Protein denotes Stat3
T25493 31372-31377 Protein denotes Actin
T25536 16951-16966 Protein denotes LMP1 Transgenic
T22054 8483-8487 Protein denotes LMP1
T22055 8488-8498 Gene_expression denotes Expression
T22056 8478-8482 Positive_regulation denotes High
T22057 8543-8547 Protein denotes LMP1
T22058 8611-8615 Protein denotes CD19
T22059 8697-8701 Protein denotes LMP1
T22060 8548-8558 Gene_expression denotes expression
T22061 8789-8793 Protein denotes LMP1
T22062 8869-8874 Protein denotes Actin
T23066 14367-14371 Protein denotes LMP1
T23067 14458-14460 Protein denotes WT
T23068 14465-14469 Protein denotes LMP1
T23069 14568-14571 Protein denotes IL4
T23070 14769-14773 Protein denotes LMP1
T24704 25723-25727 Protein denotes LMP1
T24705 25738-25741 Protein denotes Akt
T9204 19637-19641 Protein denotes LMP1
T9205 19654-19658 Protein denotes IL10
T9206 19663-19687 Protein denotes Constitutively Activates
T9207 19642-19653 Positive_regulation denotes Upregulates
T9208 19850-19854 Protein denotes CD19
T9209 19856-19860 Protein denotes MACS
T9210 19888-19901 Protein denotes RPA probe set
T9211 19906-19909 Protein denotes IL4
T9212 19911-19914 Protein denotes IL5
T9213 19916-19920 Protein denotes IL10
T22586 10554-10558 Protein denotes LMP1
T22587 10592-10616 Protein denotes Escape Allelic Exclusion
T22588 10667-10669 Protein denotes WT
T22589 10673-10677 Protein denotes LMP1
T22590 10746-10760 Protein denotes Ig heavy chain
T22591 10762-10765 Protein denotes IgM
T22592 10770-10773 Protein denotes IgD
T22593 10837-10850 Protein denotes WT lymphoma 1
T22594 10855-10859 Protein denotes LMP1
T22595 11111-11113 Protein denotes WT
T22596 11117-11121 Protein denotes LMP1
T22597 11149-11153 Protein denotes B-1a
T22598 11155-11159 Protein denotes CD19
T22599 11160-11163 Protein denotes CD5
T22600 11170-11174 Protein denotes B-1b
T22601 11178-11188 Protein denotes B2 subsets
T22602 11190-11194 Protein denotes CD19
T22603 11195-11198 Protein denotes CD5
T22604 11332-11336 Protein denotes LMP1
T22605 11436-11440 Protein denotes CD19
T22606 11457-11459 Protein denotes WT
T22607 11464-11468 Protein denotes LMP1
T22608 11486-11491 Protein denotes Actin
T23071 14813-14817 Protein denotes LMP1
T23072 14861-14866 Protein denotes CD19+
T23073 14890-14892 Protein denotes WT
T23074 14897-14901 Protein denotes LMP1
T23075 15064-15068 Protein denotes BrdU
T23076 15072-15074 Protein denotes WT
T23077 15079-15083 Protein denotes LMP1
T23078 15135-15138 Protein denotes IL4
T23079 15175-15188 Protein denotes WT lymphoma 1
T23080 15193-15197 Protein denotes LMP1
T13900 32970-32980 Negative_regulation denotes inhibition
T9214 19922-19926 Protein denotes IL13
T9215 19928-19932 Protein denotes IL15
T9216 19934-19937 Protein denotes IL9
T9217 19939-19942 Protein denotes IL2
T9218 19944-19947 Protein denotes IL6
T9219 19953-19957 Protein denotes IFNγ
T9220 20060-20068 Protein denotes gene L32
T9221 20239-20243 Protein denotes IL10
T9222 20245-20249 Protein denotes IL15
T9223 20255-20259 Protein denotes IFNγ
T9224 20290-20294 Protein denotes LMP1
T9225 20222-20235 Transcription denotes Transcription
T9226 20222-20235 Transcription denotes Transcription
T9227 20222-20235 Transcription denotes Transcription
T9228 20345-20351 Positive_regulation denotes higher
T9229 20345-20351 Positive_regulation denotes higher
T9230 20345-20351 Positive_regulation denotes higher
T9231 20474-20478 Protein denotes IL15
T9232 20483-20487 Protein denotes IFNγ
T9233 20496-20500 Protein denotes LMP1
T9234 20576-20580 Protein denotes IL15
T9235 20585-20589 Protein denotes IFNγ
T9236 20604-20608 Protein denotes LMP1
T9237 20460-20470 Gene_expression denotes expression
T9238 20460-20470 Gene_expression denotes expression
T9239 20560-20572 Positive_regulation denotes upregulation
T9240 20560-20572 Positive_regulation denotes upregulation
T9241 20609-20619 Gene_expression denotes expression
T9242 20593-20600 Positive_regulation denotes induced
T9243 20593-20600 Positive_regulation denotes induced
T9244 20710-20714 Protein denotes IL10
T9245 20803-20807 Protein denotes LMP1
T9246 20846-20850 Protein denotes LMP1
T9247 20757-20766 Positive_regulation denotes increased
T9248 20901-20905 Protein denotes IL15
T9249 20910-20914 Protein denotes IFNγ
T9250 20887-20897 Gene_expression denotes Production
T9251 20887-20897 Gene_expression denotes Production
T9252 21164-21168 Protein denotes IL10
T9253 21169-21181 Positive_regulation denotes upregulation
T9254 21287-21291 Protein denotes LMP1
T9255 21333-21337 Protein denotes LMP1
T9256 21402-21433 Protein denotes phosphorylated α and β isoforms
T13901 33048-33052 Protein denotes LMP1
T13829 29583-29593 Positive_regulation denotes activation
T13830 29777-29780 Protein denotes Akt
T13831 29782-29787 Protein denotes Stat3
T13832 29809-29813 Protein denotes IκBα
T13833 29762-29776 Phosphorylation denotes phosphorylated
T13834 29762-29776 Phosphorylation denotes phosphorylated
T13835 29892-29895 Protein denotes Akt
T13836 29916-29919 Protein denotes Akt
T13837 29873-29888 Phosphorylation denotes phosphorylation
T13838 29901-29915 Phosphorylation denotes phosphorylated
T13839 29865-29872 Negative_regulation denotes blocked
T13840 29954-29983 Protein denotes Phosphorylated Stat3 and IκBα
T13841 30074-30077 Protein denotes Akt
T13842 30087-30090 Protein denotes Akt
T13843 30066-30073 Regulation denotes targets
T13844 30091-30101 Positive_regulation denotes activation
T13845 31425-31429 Protein denotes NFκB
T13846 31535-31539 Protein denotes NFκB
T13847 31595-31599 Protein denotes LMP1
T13848 31522-31531 Negative_regulation denotes inhibitor
T13849 31790-31793 Protein denotes Akt
T13850 31795-31800 Protein denotes Stat3
T13851 31812-31816 Protein denotes IκBα
T13852 31775-31789 Phosphorylation denotes Phosphorylated
T13853 31775-31789 Phosphorylation denotes Phosphorylated
T13854 31775-31789 Phosphorylation denotes Phosphorylated
T13855 31828-31835 Positive_regulation denotes present
T13856 31828-31835 Positive_regulation denotes present
T13857 31828-31835 Positive_regulation denotes present
T13858 31828-31835 Positive_regulation denotes present
T13859 31887-31895 Positive_regulation denotes detected
T13860 31887-31895 Positive_regulation denotes detected
T13861 31887-31895 Positive_regulation denotes detected
T13862 31949-31953 Protein denotes NFκB
T13863 31979-31983 Protein denotes LMP1
T13864 32071-32074 Protein denotes Akt
T13865 32078-32083 Protein denotes Stat3
T13866 31935-31945 Negative_regulation denotes inhibition
T13867 32057-32067 Positive_regulation denotes activation
T13868 32057-32067 Positive_regulation denotes activation
T13869 32046-32053 Regulation denotes effects
T13870 32046-32053 Regulation denotes effects
T13871 32123-32128 Protein denotes Stat3
T13872 32173-32177 Protein denotes JAK2
T13873 32109-32119 Positive_regulation denotes activation
T13874 32148-32158 Positive_regulation denotes activation
T13875 32132-32143 Negative_regulation denotes suppressing
T13876 32100-32108 Negative_regulation denotes inhibits
T13877 32271-32276 Protein denotes Stat3
T13878 32261-32270 Positive_regulation denotes activated
T13879 32294-32298 Protein denotes LMP1
T13880 32501-32504 Protein denotes Akt
T13881 32506-32511 Protein denotes Stat3
T13882 32523-32527 Protein denotes IκBα
T13883 32486-32500 Phosphorylation denotes Phosphorylated
T13884 32486-32500 Phosphorylation denotes Phosphorylated
T13885 32486-32500 Phosphorylation denotes Phosphorylated
T13886 32610-32619 Negative_regulation denotes decreased
T13887 32610-32619 Negative_regulation denotes decreased
T13888 32610-32619 Negative_regulation denotes decreased
T13889 32706-32711 Protein denotes Stat3
T13890 32774-32777 Protein denotes Akt
T13891 32779-32784 Protein denotes Stat3
T13892 32799-32803 Protein denotes IκBα
T13893 32693-32702 Negative_regulation denotes inhibitor
T13894 32881-32886 Protein denotes Stat3
T13895 32912-32916 Protein denotes LMP1
T13896 32964-32969 Protein denotes Stat3
T13897 33024-33027 Protein denotes Akt
T13898 33032-33036 Protein denotes NFκB
T13899 32867-32877 Negative_regulation denotes inhibition
T13902 33085-33088 Protein denotes JNK
T13903 33093-33096 Protein denotes p38
T13904 33124-33128 Protein denotes LMP1
T13905 33226-33234 Protein denotes p38 MAPK
T13906 33267-33273 Protein denotes MEK1/2
T19015 44254-44278 Protein denotes rat IgG1 anti-mouse IL10
T18049 39486-39490 Protein denotes Cdk2
T18050 39304-39318 Negative_regulation denotes downregulation
T18051 39421-39430 Negative_regulation denotes decreased
T18583 42576-42580 Protein denotes LMP1
T18584 42596-42632 Protein denotes Ig heavy chain promoter and enhancer
T18585 42729-42733 Protein denotes LMP1
T18586 42906-42914 Protein denotes paraffin
T18587 42952-42963 Protein denotes hematoxylin
T18588 42968-42973 Protein denotes eosin
T19009 43727-43731 Protein denotes CD19
T19010 43732-43736 Protein denotes MACS
T19011 44082-44086 Protein denotes CD19
T19012 44087-44091 Protein denotes MACS
T19013 44186-44189 Protein denotes IL4
T19014 44232-44236 Protein denotes IL10
T19016 44283-44299 Protein denotes rat IgG1 isotype
T19017 44300-44307 Regulation denotes control
T19018 44300-44307 Regulation denotes control
T19019 44339-44343 Protein denotes BrdU
T19020 44407-44416 Protein denotes μM BrdU 1
T19614 44736-44739 Protein denotes IL4
T19615 44823-44826 Protein denotes IL4
T19616 45151-45154 Protein denotes IL4
T19617 45156-45200 Protein denotes rat IgG1 anti-mouse IL4, or rat IgG1 isotype
T19618 45597-45611 Protein denotes cucurbitacin I
T19619 45735-45761 Protein denotes goat F(ab') anti-mouse IgM
T19620 45763-45770 Protein denotes Jackson
T19621 45710-45717 Positive_regulation denotes induced
T20022 46081-46084 Protein denotes min
T20023 46086-46090 Protein denotes LMP1
T20024 46108-46111 Protein denotes min
T20025 46113-46119 Protein denotes pStat3
T20026 46135-46139 Protein denotes LMP1
T20027 46271-46288 Protein denotes Rat IgG anti-LMP1
T20028 46513-46546 Protein denotes streptavidin-alkaline phosphatase
T20029 46610-46614 Protein denotes BCIP
R10554 T13802 T13806 causeOf LMP1,Activation
R10555 T13802 T13807 causeOf LMP1,Activation
R10556 T13802 T13808 causeOf LMP1,Activation
R10557 T13803 T13806 themeOf Akt,Activation
R10558 T13804 T13807 themeOf NFκB,Activation
R10559 T13805 T13808 themeOf Stat3,Activation
R10560 T13811 T13816 themeOf Akt,inhibitors
R10561 T13812 T13817 themeOf NFκB,inhibitors
R10562 T13813 T13818 themeOf Stat3,inhibitors
R10563 T13814 T13819 themeOf mTOR,inhibitors
R10564 T13815 T13820 themeOf MAPK,inhibitors
R10565 T13823 T13825 themeOf Akt,activation
R10566 T13825 T13826 themeOf activation,inhibits
R10567 T13827 T13829 themeOf Akt,activation
R10568 T13830 T13833 themeOf Akt,phosphorylated
R10569 T13831 T13834 themeOf Stat3,phosphorylated
R10570 T13835 T13837 themeOf Akt,phosphorylation
R10571 T13836 T13838 themeOf Akt,phosphorylated
R10572 T13837 T13839 themeOf phosphorylation,blocked
R10573 T13841 T13843 themeOf Akt,targets
R10574 T13842 T13844 themeOf Akt,activation
R10575 T13846 T13848 themeOf NFκB,inhibitor
R10576 T13849 T13852 themeOf Akt,Phosphorylated
R10577 T13850 T13853 themeOf Stat3,Phosphorylated
R10578 T13851 T13854 themeOf IκBα,Phosphorylated
R10579 T13851 T13855 themeOf IκBα,present
R10580 T13852 T13856 themeOf Phosphorylated,present
R10581 T13852 T13859 themeOf Phosphorylated,detected
R10582 T13853 T13857 themeOf Phosphorylated,present
R10583 T13853 T13860 themeOf Phosphorylated,detected
R10584 T13854 T13858 themeOf Phosphorylated,present
R10585 T13854 T13861 themeOf Phosphorylated,detected
R10586 T13862 T13866 themeOf NFκB,inhibition
R10587 T13864 T13867 themeOf Akt,activation
R10588 T13865 T13868 themeOf Stat3,activation
R10589 T13867 T13869 themeOf activation,effects
R10590 T13868 T13870 themeOf activation,effects
R10591 T13871 T13873 themeOf Stat3,activation
R10592 T13872 T13874 themeOf JAK2,activation
R10593 T13873 T13876 themeOf activation,inhibits
R10594 T13874 T13875 themeOf activation,suppressing
R10595 T13875 T13876 causeOf suppressing,inhibits
R10596 T13877 T13878 themeOf Stat3,activated
R10597 T13880 T13883 themeOf Akt,Phosphorylated
R10598 T13880 T13886 themeOf Akt,decreased
R10599 T13881 T13884 themeOf Stat3,Phosphorylated
R10600 T13881 T13887 themeOf Stat3,decreased
R10601 T13882 T13885 themeOf IκBα,Phosphorylated
R10602 T13882 T13888 themeOf IκBα,decreased
R10603 T13889 T13893 themeOf Stat3,inhibitor
R10604 T13894 T13899 themeOf Stat3,inhibition
R10605 T13896 T13900 themeOf Stat3,inhibition
R10606 T13901 T13907 causeOf LMP1,activate
R10607 T13901 T13908 causeOf LMP1,activate
R10608 T13901 T13909 causeOf LMP1,activate
R10609 T13902 T13907 themeOf JNK,activate
R10610 T13903 T13908 themeOf p38,activate
R10611 T13904 T13909 themeOf LMP1,activate
R10612 T13905 T13910 themeOf p38 MAPK,inhibitor
R10613 T13906 T13911 themeOf MEK1/2,inhibitor
R10615 T13915 T13923 themeOf Akt,activation
R10616 T13916 T13924 themeOf NFκB,activation
R10617 T13917 T13925 themeOf Stat3,activation
R10618 T13918 T13926 themeOf MAPK,activation
R10619 T13919 T13927 themeOf mTOR,inhibitor
R10620 T13920 T13928 themeOf mTOR,targeted
R2302 T2872 T2874 themeOf Latent membrane protein 1,expressed
R2304 T2873 T2875 themeOf LMP1,expressed
R2308 T2880 T2883 themeOf CD40,interacts
R2312 T2881 T2883 themeOf CD40 ligand,interacts
R2313 T2881 T2884 themeOf CD40 ligand,expressed
R2314 T2882 T2885 themeOf LMP1,oligomerization
R2315 T2890 T2894 themeOf NFκB,activation
R2316 T2891 T2895 themeOf c-Jun N terminal kinase,activation
R2317 T2892 T2896 themeOf JNK,activation
R2318 T2897 T2898 themeOf NFκB,Activation
R2338 T2937 T2941 themeOf LMP1,express
R2339 T2910 T2912 themeOf CD40,deficient
R2340 T2944 T2949 themeOf Akt,activated
R2341 T2945 T2950 themeOf JNK,activated
R2342 T2911 T2913 themeOf CD40L,deficient
R2343 T2946 T2951 themeOf p38,activated
R2344 T2948 T2952 themeOf NFκB family,activation
R2345 T2914 T2917 themeOf CD40,bind
R2346 T2914 T2918 themeOf CD40,bind
R2347 T2914 T2916 partOf CD40,regions
R2348 T2915 T2918 themeOf TRAF6,bind
R2349 T2916 T2917 Site regions,bind
R2350 T2958 T2960 themeOf Stat6,activated
R2351 T2960 T2961 themeOf activated,absence
R2352 T2962 T2964 themeOf Stat3,activation
R2353 T2916 T2918 Site regions,bind
R3091 T3925 T3926 themeOf LMP1,Expression
R3092 T3926 T3927 themeOf Expression,Levels
R3093 T3928 T3931 themeOf LMP1,expression
R3094 T3929 T3932 themeOf IgLMP1,expression
R3095 T3930 T3933 themeOf Ig heavy chain promoter,control
R3096 T3931 T3934 themeOf expression,control
R3097 T3932 T3935 themeOf expression,control
R3098 T3936 T3937 themeOf LMP1,expression
R3099 T3938 T3940 themeOf LMP1,expression
R3100 T3941 T3944 themeOf LMP1,detectable
R3101 T3943 T3945 themeOf LMP1,expression
R3102 T3945 T3946 themeOf expression,stronger
R3103 T3947 T3949 themeOf LMP1,level
R3104 T3948 T3950 themeOf LMP1,expression
R3105 T3951 T3952 themeOf LMP1,detected
R3106 T3953 T3956 themeOf LMP1,expression
R3107 T3957 T3959 themeOf LMP1,expression
R3108 T3960 T3963 themeOf LMP1,increased
R3109 T3961 T3964 themeOf LMP1,expression
R3110 T3962 T3965 themeOf LMP1,expressing
R3111 T3964 T3966 themeOf expression,increase
R3112 T3967 T3969 themeOf LMP1,expression
R3113 T3968 T3970 themeOf LMP1,increased
R3114 T3969 T3971 themeOf expression,high
R4279 T5329 T5334 themeOf LMP1,expression
R4280 T5350 T5354 themeOf one heavy chain isotype,express
R4281 T5351 T5355 themeOf IgG,express
R4282 T5352 T5356 themeOf IgE,express
R4283 T5353 T5357 themeOf IgA,express
R4284 T5362 T5363 themeOf LMP1,expression
R4842 T6192 T6193 themeOf CD40,ligation
R4843 T6197 T6198 themeOf CD40,ligation
R4844 T6198 T6199 themeOf ligation,lack
R4845 T6201 T6203 themeOf IL4,enhanced
R4846 T6215 T6217 themeOf IL4,requirement
R4847 T6218 T6221 themeOf LMP1,expression
R4848 T6220 T6222 themeOf LMP1,expression
R4849 T6225 T6226 themeOf LMP1,negative
R4850 T6228 T6232 themeOf L2,express
R4851 T6228 T6235 themeOf L2,high
R4852 T6229 T6233 themeOf LMP1-L5,express
R4853 T6230 T6234 themeOf LMP1,express
R4854 T6232 T6236 themeOf express,high
R4855 T6233 T6237 themeOf express,high
R4856 T6234 T6238 themeOf express,high
R5505 T7111 T7114 themeOf IL4,expression
R5506 T7112 T7115 themeOf IL4,transcription
R5507 T7116 T7117 themeOf IL4,transcription
R5508 T7118 T7124 themeOf IL4,transcription
R5509 T7125 T7129 themeOf Stat6,Activated
R5510 T7126 T7130 themeOf pStat6,Activated
R5511 T7134 T7135 themeOf Stat6,phosphorylation
R5512 T7135 T7136 themeOf phosphorylation,induced
R5513 T7140 T7143 causeOf IL4,affect
R5514 T7141 T7143 themeOf MTS,affect
R7142 T9225 T9228 themeOf Transcription,higher
R7143 T9226 T9229 themeOf Transcription,higher
R7144 T9227 T9230 themeOf Transcription,higher
R7145 T9260 T9264 themeOf levels,increased
R7146 T9231 T9237 themeOf IL15,expression
R7147 T9232 T9238 themeOf IFNγ,expression
R7148 T9265 T9267 themeOf IL10,induction
R7149 T9266 T9268 themeOf Stat3,activation
R7150 T9234 T9239 themeOf IL15,upregulation
R7151 T9269 T9272 themeOf Stat3,activation
R7152 T9270 T9273 causeOf IL10,induced
R7153 T9271 T9274 themeOf Stat3,activation
R7154 T9272 T9273 themeOf activation,induced
R7155 T9235 T9240 themeOf IFNγ,upregulation
R7156 T9275 T9277 themeOf LMP1,expression
R7157 T9276 T9278 themeOf IL10,induction
R7158 T9236 T9241 themeOf LMP1,expression
R7159 T9279 T9281 themeOf IL10,induction
R7160 T9239 T9242 themeOf upregulation,induced
R7161 T9280 T9282 causeOf LMP1,affected
R7162 T9281 T9282 themeOf induction,affected
R7163 T9284 T9285 themeOf Stat3,activation
R7164 T9240 T9243 themeOf upregulation,induced
R7165 T9287 T9289 themeOf pStat3,activated
R7166 T9241 T9242 causeOf expression,induced
R7167 T9241 T9243 causeOf expression,induced
R7168 T9290 T9294 causeOf IL10,enhanced
R7169 T9244 T9247 themeOf IL10,increased
R7170 T9291 T9293 themeOf pStat3,activation
R7171 T9293 T9294 themeOf activation,enhanced
R7172 T9295 T9297 themeOf Stat3,activation
R7173 T9248 T9250 themeOf IL15,Production
R7174 T9296 T9298 themeOf IL10,induction
R7175 T9297 T9299 themeOf activation,enhanced
R7176 T9298 T9299 causeOf induction,enhanced
R7177 T9249 T9251 themeOf IFNγ,Production
R7178 T9304 T9306 themeOf pStat3,translocation
R7179 T9252 T9253 themeOf IL10,upregulation
R7180 T9305 T9306 locationOf Nuclear,translocation
R7181 T9256 T9259 themeOf phosphorylated α and β isoforms,levels
R7182 T9310 T9314 themeOf pStat3,activation
R7183 T9311 T9315 themeOf Stat3,activation
R7184 T9257 T9260 themeOf Stat3,levels
R7185 T9257 T9261 themeOf Stat3,activated
R7186 T9258 T9262 themeOf IL10 receptor,target
R7187 T9259 T9263 themeOf levels,increased
R8664 T11345 T11348 causeOf LMP1,Activates
R8665 T11346 T11348 themeOf Akt,Activates
R8666 T11350 T11352 themeOf PI3K,activation
R8667 T11351 T11353 causeOf Akt [5],requires
R8668 T11352 T11353 themeOf activation,requires
R8669 T11354 T11355 themeOf pAkt,activated
R8670 T11361 T11362 themeOf pAkt,increase
R8671 T11363 T11366 themeOf Akt target glycogen synthase kinase 3,inactivated
R8672 T11364 T11367 themeOf GSK3,inactivated
R8673 T11365 T11368 themeOf GSK3,phosphorylated
R8674 T11368 T11369 themeOf phosphorylated,increased
R8675 T11370 T11373 themeOf GSK3,target
R8676 T11371 T11373 themeOf Akt,target
R8677 T11371 T11374 themeOf Akt,activated
R8678 T11375 T11377 themeOf Akt,activation
R8679 T11376 T11378 themeOf GSK3,phosphorylation
R8680 T11378 T11379 themeOf phosphorylation,activation
R8681 T11380 T11382 themeOf Akt,activated
R8682 T11381 T11383 themeOf GSK3,phosphorylated
R8683 T11384 T11385 themeOf GSK3,regulation
R8684 T11386 T11390 themeOf Activated p-mTOR,increased
R8685 T11392 T11393 themeOf FoxO1,degradation
R8686 T11393 T11394 themeOf degradation,targets
R8687 T11395 T11397 themeOf FoxO1,degradation
R8688 T11398 T11402 themeOf FoxO1,decreased
R8689 T11400 T11403 themeOf Forkhead,inhibition
R8690 T11401 T11404 themeOf Akt,target
R8691 T11405 T11410 themeOf Akt,activation
R8692 T11406 T11411 themeOf FoxO1,degradation
R8693 T11408 T11412 causeOf Akt,regulator
R8694 T11409 T11412 themeOf FoxO1,regulator
R8695 T11414 T11415 themeOf Cdk,expression
R8696 T11417 T11419 themeOf p27,expression
R8697 T11418 T11420 themeOf Cdk2,upregulation
R8698 T11428 T11431 themeOf pRb,enhanced
R8699 T11430 T11432 themeOf Cdk2,enhanced
R8700 T11434 T11437 themeOf Rb,increased
R8701 T11436 T11438 themeOf p27,decreased
R8702 T11441 T11442 themeOf p27,loss
R8703 T11441 T11443 themeOf p27,decreased
R8704 T11443 T11444 themeOf decreased,loss
R13893 T17953 T17955 themeOf LMP1,expression
R13895 T17961 T17964 themeOf CD40,deficient
R13896 T18014 T18017 themeOf NFκB,inhibition
R13897 T17965 T17966 themeOf LMP1,expression
R13898 T18021 T18025 themeOf cRel,deficient
R13899 T17974 T17977 themeOf IgM,source
R13900 T17975 T17976 themeOf IgA antibodies,produce
R13901 T17975 T17978 themeOf IgA antibodies,source
R13902 T17979 T17980 themeOf LMP1,expressed
R13903 T18022 T18026 themeOf p85 regulatory subunit,deficient
R13904 T17981 T17982 themeOf LMP1,expression
R13905 T17982 T17983 themeOf expression,elevated
R13906 T18023 T18027 themeOf PI3K,deficient
R13907 T18024 T18028 themeOf CD40,ligation
R13908 T17987 T17992 themeOf IL10,upregulation
R13909 T18029 T18032 themeOf cRel,activated
R13910 T17989 T17993 themeOf Akt,activation
R13911 T17990 T17994 themeOf NFκB,activation
R13912 T17991 T17995 themeOf Stat3,activation
R13913 T17993 T17996 themeOf activation,requirement
R13914 T17994 T17997 themeOf activation,requirement
R13915 T17995 T17998 themeOf activation,requirement
R13916 T18031 T18033 themeOf cRel,activation
R13917 T18036 T18040 causeOf PI3K,activation
R13918 T17999 T18000 themeOf IL10,Induction
R13919 T18001 T18004 causeOf LMP1,stimulate
R13920 T18002 T18003 themeOf IL10,expression
R13921 T18003 T18004 themeOf expression,stimulate
R13922 T18005 T18008 themeOf Stat3,activated
R13923 T18006 T18009 themeOf IL10,induction
R13924 T18037 T18040 themeOf Akt,activation
R13925 T18007 T18010 themeOf Stat3,activation
R13926 T18038 T18041 themeOf NFκB,activation
R13927 T18009 T18011 causeOf induction,enhance
R13928 T18010 T18011 themeOf activation,enhance
R13929 T18039 T18042 themeOf cRel,activation
R13930 T18043 T18055 causeOf CD40,induces
R13931 T18049 T18054 themeOf Cdk2,increased
R13932 T18050 T18055 themeOf downregulation,induces
R13933 T18044 T18050 themeOf p27,downregulation
R13934 T18047 T18051 themeOf p27,decreased
R13935 T18047 T18052 themeOf p27,phosphorylation
R13936 T18058 T18060 themeOf Akt,activation
R13937 T18059 T18061 themeOf Akt,inhibitor
R13938 T18048 T18053 themeOf Rb,phosphorylation
R13939 T18060 T18062 themeOf activation,requirement
R13940 T18083 T18084 themeOf bcl6,downregulation
R13941 T18063 T18065 themeOf pAkt,activated
R13942 T18063 T18066 causeOf pAkt,lead
R13943 T18064 T18067 themeOf GSK3,phosphorylation
R13944 T18065 T18066 themeOf activated,lead
R13945 T18085 T18087 themeOf LMP1,expression
R13946 T18067 T18068 themeOf phosphorylation,inactivation
R13947 T18086 T18088 themeOf bcl6,expression
R13948 T18071 T18072 themeOf Fox01 transcription factors,inhibition
R13949 T18072 T18073 themeOf inhibition,target
R13950 T18090 T18095 themeOf Akt,activation
R13951 T18074 T18077 themeOf FoxO1,Repression
R13952 T18076 T18078 themeOf bcl6,expression
R13953 T18077 T18079 causeOf Repression,inhibit
R13954 T18078 T18079 themeOf expression,inhibit
R13955 T18091 T18096 themeOf Fox01,lack
R13956 T18093 T18097 themeOf p27,regulation
R13957 T18094 T18098 themeOf CyclinD2,regulation
R13958 T18099 T18100 themeOf FoxO1,expression
R13961 T18100 T18101 themeOf expression,loss
R13962 T18102 T18104 themeOf CyclinD2,upregulated
R13963 T18103 T18104 causeOf LMP1,upregulated
R13964 T18107 T18110 themeOf p27,decreased
R13966 T18108 T18111 themeOf Akt,activated
R13968 T18115 T18117 themeOf NFκB,activation
R13969 T18117 T18118 themeOf activation,requires
R14698 T19015 T19017 themeOf rat IgG1 anti-mouse IL10,control
R14699 T19016 T19018 themeOf rat IgG1 isotype,control
R15241 T19619 T19621 themeOf goat F(ab') anti-mouse IgM,induced
R15848 T20319 T20320 themeOf BrdU,detection
R18438 T23624 T23627 themeOf pStat6,activated
R18903 T24242 T24245 causeOf LMP1,Upregulates
R18904 T24243 T24244 themeOf IL10,Expression
R18905 T24244 T24245 themeOf Expression,Upregulates
R18906 T24246 T24253 themeOf IL10,expression
R18907 T24247 T24254 themeOf IL15,expression
R18908 T24248 T24255 themeOf IFNγ mRNA,expression
R18909 T24257 T24264 themeOf pStat3,activated
R18910 T24263 T24265 themeOf rat IgG1 isotype,control
R7123 T9204 T9207 causeOf LMP1,Upregulates
R7136 T9205 T9207 themeOf IL10,Upregulates
R7137 T9221 T9225 themeOf IL10,Transcription
R7140 T9222 T9226 themeOf IL15,Transcription
R7141 T9223 T9227 themeOf IFNγ,Transcription
R17252 T22054 T22055 themeOf LMP1,Expression
R17253 T22055 T22056 themeOf Expression,High
R17254 T22057 T22060 themeOf LMP1,expression
R19207 T24704 T24707 causeOf LMP1,Activates
R19208 T24705 T24707 themeOf Akt,Activates
R19209 T24712 T24715 themeOf pAkt,activated
R19210 T24713 T24716 themeOf pGSK3α/β,inactivated
R19211 T24719 T24724 themeOf pRb,activated
R19212 T24720 T24723 themeOf Cdk2,regulating
R19546 T25177 T25183 themeOf NFκB,inhibitors
R19547 T25178 T25184 themeOf BAY11,inhibitors
R19548 T25179 T25185 themeOf mTOR,inhibitors
R19549 T25180 T25186 themeOf rapamycin,inhibitors
R19550 T25181 T25187 themeOf p38,inhibitors
R19551 T25182 T25188 themeOf SB202190,inhibitors
R19762 T25486 T25489 themeOf Akt,inhibitor
R19763 T25487 T25490 themeOf NFκB,inhibitor
R19764 T25488 T25491 themeOf Stat3,inhibitors
R337 T472 T476 causeOf EBV Latent Membrane Protein 1,Activates
R338 T472 T477 causeOf EBV Latent Membrane Protein 1,Activates
R339 T472 T478 causeOf EBV Latent Membrane Protein 1,Activates
R340 T473 T476 themeOf Akt,Activates
R341 T474 T477 themeOf NFκB,Activates
R342 T475 T478 themeOf Stat3,Activates
R343 T482 T486 themeOf Akt,inhibitors
R344 T483 T487 themeOf NFκB,inhibitors
R345 T484 T488 themeOf Stat3,inhibitors
R2319 T2919 T2930 causeOf LMP1,restore
R2320 T2920 T2925 themeOf CD40,deficient
R2321 T2921 T2927 themeOf immunoglobulin,switching
R2322 T2921 T2926 partOf immunoglobulin,class
R2323 T2922 T2926 partOf Ig,class
R2324 T2899 T2904 causeOf LMP1,activates
R2325 T2923 T2928 themeOf LMP1,recruits
R2326 T2923 T2929 partOf LMP1,domains
R2327 T2924 T2928 themeOf TRAF6,recruits
R2328 T2926 T2927 Site class,switching
R2329 T2926 T2928 Site class,recruits
R2330 T2927 T2930 themeOf switching,restore
R2331 T2899 T2905 causeOf LMP1,activates
R2332 T2900 T2904 themeOf phosphatidylinositol 3 kinase,activates
R2333 T2902 T2905 themeOf Akt,activates
R2334 T2933 T2934 themeOf Ig heavy chain promoter,control
R2335 T2906 T2908 themeOf CD40,ligation
R2336 T2935 T2939 themeOf LMP1 transgenic mice,express
R2337 T2936 T2940 themeOf IgLMP1,express

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T57 909-912 Protein denotes Akt
T58 924-929 Protein denotes Stat3
T706 3314-3319 Protein denotes c-Jun
T707 3542-3546 Protein denotes LMP1
T708 3599-3602 Protein denotes Akt
T709 3654-3658 Protein denotes LMP1
T710 3760-3764 Protein denotes CD40
T711 3765-3773 Binding denotes ligation
T712 3794-3797 Protein denotes IL4
T713 3818-3822 Protein denotes CD40
T714 3896-3905 Negative_regulation denotes deficient
T715 3896-3905 Negative_regulation denotes deficient
T716 3910-3914 Protein denotes CD40
T717 3918-3923 Protein denotes CD40L
T718 4006-4023 Entity denotes membrane proximal
T719 4028-4054 Entity denotes distal cytoplasmic regions
T720 4058-4062 Protein denotes CD40
T721 4068-4072 Binding denotes bind
T722 4068-4072 Binding denotes bind
T723 4068-4072 Binding denotes bind
T724 4068-4072 Binding denotes bind
T725 4073-4078 Protein denotes TRAF6
T726 4083-4089 Protein denotes TRAFs2
T727 4090-4091 Protein denotes 3
T728 4092-4093 Protein denotes 5
T729 4287-4291 Protein denotes LMP1
T730 4296-4302 Negative_regulation denotes rescue
T731 4303-4307 Protein denotes CD40
T732 4308-4317 Negative_regulation denotes deficient
T733 4392-4396 Protein denotes LMP1
T734 4397-4405 Binding denotes recruits
T735 4397-4405 Binding denotes recruits
T736 4397-4405 Binding denotes recruits
T737 4397-4405 Binding denotes recruits
T738 4397-4405 Binding denotes recruits
T739 4430-4437 Protein denotes TRAFs 1
T740 4438-4439 Protein denotes 2
T741 4440-4441 Protein denotes 3
T742 4442-4443 Protein denotes 5
T743 4448-4453 Protein denotes TRAF6
T744 4467-4498 Entity denotes C-terminal activation regions 1
T745 4503-4512 Entity denotes 2 domains
T746 4537-4541 Protein denotes LMP1
T747 4700-4704 Protein denotes LMP1
T748 4736-4745 Gene_expression denotes expressed
T749 4746-4763 Positive_regulation denotes under the control
T750 4821-4825 Protein denotes LMP1
T751 4851-4858 Gene_expression denotes express
T752 4859-4863 Protein denotes LMP1
T753 5023-5027 Protein denotes LMP1
T754 5071-5075 Protein denotes LMP1
T755 5120-5129 Positive_regulation denotes activated
T756 5130-5133 Protein denotes Akt
T757 5169-5179 Positive_regulation denotes activation
T758 5206-5210 Protein denotes cRel
T759 5236-5240 Protein denotes LMP1
T760 5684-5688 Protein denotes LMP1
T761 5792-5795 Protein denotes IL4
T3184 7979-7985 Positive_regulation denotes weakly true
T3186 8026-8030 Protein denotes LMP1
T3187 8031-8041 Gene_expression denotes expression
T3188 8051-8061 Positive_regulation denotes abundantly
T3189 8093-8100 Positive_regulation denotes intense
T3190 8101-8105 Protein denotes LMP1
T3191 8143-8152 Positive_regulation denotes increased
T3192 8153-8157 Protein denotes LMP1
T3193 8224-8232 Positive_regulation denotes increase
T3194 8236-8240 Protein denotes LMP1
T3195 8241-8251 Gene_expression denotes expression
T3196 8281-8291 Gene_expression denotes expressing
T3197 8292-8303 Positive_regulation denotes high levels
T3198 8307-8311 Protein denotes LMP1
T3199 8338-8342 Positive_regulation denotes high
T3200 8343-8347 Protein denotes LMP1
T3201 8348-8358 Gene_expression denotes expression
T3202 8442-8451 Positive_regulation denotes increased
T3203 8452-8458 Gene_expression denotes levels
T3204 8462-8466 Protein denotes LMP1
T5480 13052-13056 Protein denotes LMP1
T5481 13159-13163 Protein denotes CD40
T5482 13164-13172 Binding denotes ligation
T5483 13198-13201 Protein denotes IL4
T6373 17567-17576 Positive_regulation denotes Activated
T6374 17577-17582 Protein denotes Stat6
T6375 17584-17590 Protein denotes pStat6
T6376 17595-17601 Regulation denotes target
T6377 17609-17621 Protein denotes IL4 receptor
T6378 17665-17669 Protein denotes LMP1
T6379 17773-17777 Protein denotes LMP1
T6380 17884-17887 Protein denotes IL4
T6381 17888-17895 Positive_regulation denotes induced
T6382 17896-17901 Protein denotes Stat6
T6383 17902-17917 Phosphorylation denotes phosphorylation
T6384 19044-19047 Protein denotes IL4
T6385 19288-19291 Protein denotes IL4
T6386 19357-19360 Protein denotes IL4
T6387 19419-19422 Protein denotes IL4
T6388 19458-19462 Protein denotes LMP1
T6389 19532-19536 Protein denotes LMP1
T6390 19585-19588 Protein denotes IL4
T6391 19619-19624 Protein denotes Stat6
T7433 19939-19942 Protein denotes IL2
T7434 19944-19947 Protein denotes IL6
T7435 19953-19957 Protein denotes IFNγ
T7436 20065-20068 Protein denotes L32
T7437 20104-20112 Gene_expression denotes detected true
T7438 20104-20112 Gene_expression denotes detected true
T7439 20104-20112 Gene_expression denotes detected true
T7440 20104-20112 Gene_expression denotes detected true
T7441 20104-20112 Gene_expression denotes detected true
T7442 20104-20112 Gene_expression denotes detected true
T7443 20104-20112 Gene_expression denotes detected true
T7444 20104-20112 Gene_expression denotes detected true
T7445 20104-20112 Gene_expression denotes detected true
T7446 20158-20161 Protein denotes L32
T7447 20222-20235 Transcription denotes Transcription
T7448 20222-20235 Transcription denotes Transcription
T7449 20222-20235 Transcription denotes Transcription
T7450 20239-20243 Protein denotes IL10
T7451 20245-20249 Protein denotes IL15
T7452 20255-20259 Protein denotes IFNγ
T7453 20290-20294 Protein denotes LMP1
T7454 20345-20351 Positive_regulation denotes higher
T7455 20345-20351 Positive_regulation denotes higher
T7456 20345-20351 Positive_regulation denotes higher
T7457 20460-20470 Gene_expression denotes expression
T7458 20460-20470 Gene_expression denotes expression
T7459 20474-20478 Protein denotes IL15
T7460 20483-20487 Protein denotes IFNγ
T7461 20496-20500 Protein denotes LMP1
T7462 20528-20542 Protein denotes lymphoma cells
T7463 20560-20572 Positive_regulation denotes upregulation
T7464 20560-20572 Positive_regulation denotes upregulation
T7465 20576-20580 Protein denotes IL15
T7466 20585-20589 Protein denotes IFNγ
T7467 20593-20600 Positive_regulation denotes induced true
T7468 20593-20600 Positive_regulation denotes induced true
T7469 20604-20608 Protein denotes LMP1
T7470 20609-20619 Gene_expression denotes expression
T7471 20710-20714 Protein denotes IL10
T7472 20757-20766 Positive_regulation denotes increased
T7473 20803-20807 Protein denotes LMP1
T7474 20846-20850 Protein denotes LMP1
T7475 20887-20897 Gene_expression denotes Production
T7476 20887-20897 Gene_expression denotes Production
T7477 20901-20905 Protein denotes IL15
T7478 20910-20914 Protein denotes IFNγ
T7479 21112-21124 Positive_regulation denotes upregulation
T7480 21128-21132 Protein denotes IL10
T7481 21164-21168 Protein denotes IL10
T7482 21169-21181 Positive_regulation denotes upregulation
T7483 21287-21291 Protein denotes LMP1
T7484 21333-21337 Protein denotes LMP1
T7485 21382-21391 Positive_regulation denotes increased
T7486 21402-21416 Phosphorylation denotes phosphorylated
T7487 21437-21446 Positive_regulation denotes activated
T7488 21447-21452 Protein denotes Stat3
T7489 21456-21462 Regulation denotes target
T7490 21470-21474 Protein denotes IL10
T7491 21554-21565 Regulation denotes correlation true
T7492 21588-21592 Protein denotes IL10
T7493 21593-21602 Positive_regulation denotes induction
T7494 21621-21626 Protein denotes Stat3
T7495 21627-21637 Positive_regulation denotes activation
T7496 21662-21672 Positive_regulation denotes activation
T7497 21676-21681 Protein denotes Stat3
T7498 21696-21703 Positive_regulation denotes induced true true
T7499 21707-21711 Protein denotes IL10
T7500 21720-21725 Protein denotes Stat3
T7501 21785-21796 Regulation denotes correlation true
T7502 21819-21823 Protein denotes LMP1
T7503 21824-21834 Gene_expression denotes expression
T7504 21853-21857 Protein denotes IL10
T7505 21858-21867 Positive_regulation denotes induction
T7506 21913-21922 Positive_regulation denotes induction
T9680 24978-24982 Protein denotes LMP1
T9681 25037-25045 Positive_regulation denotes increase true
T9682 25046-25050 Protein denotes pAkt
T9683 25063-25066 Protein denotes Akt
T9684 25067-25073 Binding denotes target
T9685 25074-25100 Protein denotes glycogen synthase kinase 3
T9686 25102-25106 Protein denotes GSK3
T9687 25111-25122 Negative_regulation denotes inactivated
T9688 25152-25161 Positive_regulation denotes increased true
T9689 25162-25176 Phosphorylation denotes phosphorylated
T9690 25177-25181 Protein denotes GSK3
T9691 25316-25320 Protein denotes GSK3
T9692 25330-25336 Binding denotes target true
T9693 25340-25349 Positive_regulation denotes activated
T9694 25350-25353 Protein denotes Akt
T9695 25361-25365 Protein denotes LMP1
T9696 25420-25430 Positive_regulation denotes activation
T9697 25434-25437 Protein denotes Akt
T9698 25446-25461 Phosphorylation denotes phosphorylation
T9699 25465-25469 Protein denotes GSK3
T9700 25567-25576 Positive_regulation denotes activated true
T9701 25577-25580 Protein denotes Akt
T9702 25605-25619 Phosphorylation denotes phosphorylated
T9703 25620-25624 Protein denotes GSK3
T9704 25693-25703 Regulation denotes regulation
T9705 25707-25711 Protein denotes GSK3
T9706 26410-26413 Protein denotes Akt
T9707 26414-26421 Binding denotes targets true
T9708 26447-26453 Protein denotes p-mTOR
T9709 26469-26478 Positive_regulation denotes Activated
T9710 26479-26485 Protein denotes p-mTOR
T9711 26494-26503 Positive_regulation denotes increased true
T9712 26507-26511 Protein denotes LMP1
T9713 26590-26598 Regulation denotes affected true
T9714 26602-26606 Protein denotes LMP1
T9715 26607-26614 Positive_regulation denotes induced
T9716 26615-26618 Protein denotes Akt
T9717 26619-26629 Positive_regulation denotes activation
T9718 26691-26694 Protein denotes Akt
T9719 26962-26967 Protein denotes FoxO1
T9720 26990-26997 Regulation denotes targets
T9721 26998-27003 Protein denotes FoxO1
T9722 27043-27048 Protein denotes FoxO1
T9723 27084-27089 Protein denotes FoxO1
T9724 27139-27144 Protein denotes FoxO1
T9725 27165-27174 Negative_regulation denotes decreased
T9726 27192-27196 Protein denotes LMP1
T9727 27318-27321 Protein denotes Akt
T9728 27373-27376 Protein denotes Akt
T9729 27377-27387 Positive_regulation denotes activation
T9730 27396-27402 Positive_regulation denotes induce true
T9731 27403-27408 Protein denotes FoxO1
T9732 27409-27420 Negative_regulation denotes degradation
T9733 27424-27428 Protein denotes LMP1
T9734 27449-27452 Protein denotes Akt
T9735 27473-27482 Regulation denotes regulator true true
T9736 27486-27491 Protein denotes FoxO1
T9737 27646-27656 Gene_expression denotes expression
T9738 27678-27681 Protein denotes p27
T9739 27691-27695 Protein denotes LMP1
T9740 27756-27759 Protein denotes p27
T9741 27777-27781 Protein denotes Cdk2
T9742 27860-27862 Protein denotes Rb
T9743 27892-27896 Protein denotes LMP1
T9744 27940-27942 Protein denotes Rb
T9745 27987-27990 Protein denotes pRb
T9746 27992-27996 Protein denotes Cdk2
T9747 28002-28005 Protein denotes p27
T11759 29762-29776 Phosphorylation denotes phosphorylated
T11760 29762-29776 Phosphorylation denotes phosphorylated
T11761 29777-29780 Protein denotes Akt
T11762 29782-29787 Protein denotes Stat3
T11763 29809-29813 Protein denotes IκBα
T11764 29865-29872 Negative_regulation denotes blocked
T11765 29873-29888 Phosphorylation denotes phosphorylation
T11766 29892-29895 Protein denotes Akt
T11767 29901-29915 Phosphorylation denotes phosphorylated
T11768 29916-29919 Protein denotes Akt
T11769 29934-29942 Positive_regulation denotes detected true
T11770 29954-29968 Phosphorylation denotes Phosphorylated
T11771 29954-29968 Phosphorylation denotes Phosphorylated
T11772 29969-29974 Protein denotes Stat3
T11773 29979-29983 Protein denotes IκBα
T11774 30066-30073 Regulation denotes targets true
T11800 32173-32177 Protein denotes JAK2
T11801 32261-32270 Positive_regulation denotes activated
T11802 32271-32276 Protein denotes Stat3
T11803 32294-32298 Protein denotes LMP1
T11804 32486-32500 Phosphorylation denotes Phosphorylated
T11805 32486-32500 Phosphorylation denotes Phosphorylated
T11806 32501-32504 Protein denotes Akt
T11807 32506-32511 Protein denotes Stat3
T11808 32523-32527 Protein denotes IκBα
T11809 32537-32547 Positive_regulation denotes detectable true
T11810 32537-32547 Positive_regulation denotes detectable true
T11811 32537-32547 Positive_regulation denotes detectable true
T11812 32610-32619 Negative_regulation denotes decreased
T11813 32610-32619 Negative_regulation denotes decreased
T11814 32610-32619 Negative_regulation denotes decreased
T11815 32693-32702 Negative_regulation denotes inhibitor
T11816 32706-32711 Protein denotes Stat3
T11817 32774-32777 Protein denotes Akt
T11818 32779-32784 Protein denotes Stat3
T11819 32799-32803 Protein denotes IκBα
T11820 32818-32826 Regulation denotes affected true
T11821 32867-32877 Negative_regulation denotes inhibition
T11822 32881-32886 Protein denotes Stat3
T11823 32912-32916 Protein denotes LMP1
T11824 32964-32969 Protein denotes Stat3
T11825 32970-32980 Negative_regulation denotes inhibition
T11826 33024-33027 Protein denotes Akt
T11827 33048-33052 Protein denotes LMP1
T11828 33124-33128 Protein denotes LMP1
T11829 33254-33263 Negative_regulation denotes inhibitor
T11830 33254-33263 Negative_regulation denotes inhibitor
T11831 33267-33271 Protein denotes MEK1
T11832 33272-33273 Protein denotes 2
T11833 33491-33495 Protein denotes LMP1
T11834 33583-33587 Protein denotes LMP1
T11835 33770-33773 Protein denotes Akt
T11836 33785-33790 Protein denotes Stat3
T11837 33900-33909 Negative_regulation denotes inhibitor
T11838 33913-33917 Protein denotes mTOR
T11839 34013-34017 Protein denotes mTOR
T11840 34025-34033 Regulation denotes targeted true
T11841 34037-34040 Protein denotes Akt
T11842 34055-34059 Protein denotes LMP1
T14353 35010-35014 Protein denotes LMP1
T14354 35076-35080 Protein denotes CD40
T14355 35081-35090 Negative_regulation denotes deficient
T14356 35226-35230 Protein denotes CD40
T14357 35244-35248 Protein denotes LMP1
T14358 35333-35343 Gene_expression denotes expression
T14359 35347-35351 Protein denotes LMP1
T14360 35556-35560 Protein denotes LMP1
T14361 35620-35624 Protein denotes LMP2
T14362 35794-35798 Protein denotes LMP2
T14363 35937-35941 Protein denotes LMP2
T14364 36090-36094 Protein denotes LMP1
T14365 36164-36168 Protein denotes LMP1
T14366 36360-36364 Protein denotes CD40
T14367 37076-37080 Protein denotes LMP1
T14368 37084-37093 Gene_expression denotes expressed
T14369 37199-37207 Positive_regulation denotes elevated
T14370 37208-37218 Gene_expression denotes expression
T14371 37222-37226 Protein denotes LMP1
T14372 37518-37522 Protein denotes LMP1
T14373 37644-37648 Protein denotes LMP1
T14374 37832-37844 Positive_regulation denotes upregulation
T14375 37848-37852 Protein denotes IL10
T14376 37881-37886 Protein denotes Stat3
T14377 37934-37937 Protein denotes Akt
T14378 37949-37954 Protein denotes Stat3
T14379 37983-37992 Positive_regulation denotes Induction
T14380 37996-38000 Protein denotes IL10
T14381 38194-38198 Protein denotes LMP1
T14382 38217-38226 Positive_regulation denotes stimulate
T14383 38227-38231 Protein denotes IL10
T14384 38232-38242 Gene_expression denotes expression
T14385 38311-38316 Protein denotes Stat3
T14386 38335-38344 Positive_regulation denotes activated
T14387 38372-38381 Positive_regulation denotes induction
T14388 38385-38389 Protein denotes IL10
T14389 38402-38409 Positive_regulation denotes enhance true
T14390 38410-38415 Protein denotes Stat3
T14391 38416-38426 Positive_regulation denotes activation
T14392 38454-38458 Protein denotes IL10
T14393 38490-38494 Protein denotes LMP1
T14394 38628-38632 Protein denotes LMP1
T14395 38660-38664 Protein denotes LMP1
T14396 38744-38748 Protein denotes CD40
T14397 38781-38790 Negative_regulation denotes deficient
T14398 38781-38790 Negative_regulation denotes deficient
T14399 38795-38799 Protein denotes cRel
T14400 38807-38810 Protein denotes p85
T14401 38887-38891 Protein denotes CD40
T14402 38892-38900 Binding denotes ligation
T14403 38940-38944 Protein denotes cRel
T14404 38961-38970 Positive_regulation denotes activated
T14405 38993-38997 Protein denotes LMP1
T14406 39036-39046 Positive_regulation denotes activation
T14407 39050-39054 Protein denotes cRel
T14408 39143-39147 Protein denotes CD40
T14409 39171-39175 Protein denotes LMP1
T14410 39176-39183 Positive_regulation denotes induces
T14411 39176-39183 Positive_regulation denotes induces
T14412 39220-39230 Positive_regulation denotes activation
T14413 39234-39237 Protein denotes Akt
T14414 39242-39252 Positive_regulation denotes activation
T14415 39280-39284 Protein denotes cRel
T14416 39286-39290 Protein denotes CD40
T14417 39296-39303 Positive_regulation denotes induces
T14418 39304-39318 Negative_regulation denotes downregulation
T14419 39347-39350 Protein denotes p27
T14420 39392-39396 Protein denotes LMP1
T14421 39421-39430 Negative_regulation denotes decreased
T14422 39441-39444 Protein denotes p27
T14423 39450-39465 Phosphorylation denotes phosphorylation
T14424 39469-39471 Protein denotes Rb
T14425 39476-39485 Positive_regulation denotes increased
T14426 39486-39490 Protein denotes Cdk2
T14427 39518-39522 Protein denotes LMP1
T14428 39556-39558 Protein denotes Rb
T14429 39681-39692 Positive_regulation denotes requirement
T14430 39697-39700 Protein denotes Akt
T14431 39701-39711 Positive_regulation denotes activation
T14432 39794-39797 Protein denotes Akt
T14433 39798-39807 Negative_regulation denotes inhibitor
T14434 39822-39831 Positive_regulation denotes activated
T14435 39832-39836 Protein denotes pAkt
T14436 39845-39849 Positive_regulation denotes lead true
T14437 39845-39849 Positive_regulation denotes lead true
T14438 39853-39868 Phosphorylation denotes phosphorylation
T14439 39873-39885 Negative_regulation denotes inactivation
T14440 39911-39915 Protein denotes GSK3
T14441 40074-40078 Protein denotes LMP1
T14442 40123-40127 Protein denotes LMP1
T14443 40226-40233 Negative_regulation denotes absence
T14444 40237-40246 Positive_regulation denotes activated
T14445 40247-40253 Protein denotes p-mTOR
T14446 40308-40311 Protein denotes Akt
T14447 40365-40371 Regulation denotes target
T14448 40386-40396 Negative_regulation denotes inhibition
T14449 40404-40409 Protein denotes Fox01
T14450 40433-40443 Negative_regulation denotes Repression
T14451 40486-40491 Protein denotes FoxO1
T14452 40523-40530 Negative_regulation denotes inhibit
T14453 40531-40541 Gene_expression denotes expression
T14454 40545-40549 Protein denotes bcl6
T14455 40652-40656 Protein denotes CD40
T14456 40750-40754 Protein denotes CD40
T14457 40777-40781 Protein denotes LMP1
T14458 40861-40865 Protein denotes LMP1
T14459 40901-40915 Negative_regulation denotes downregulation
T14460 40919-40923 Protein denotes bcl6
T14461 40971-40981 Gene_expression denotes expression
T14462 40971-40981 Gene_expression denotes expression
T14463 40985-40989 Protein denotes LMP1
T14464 40994-40998 Protein denotes bcl6
T14465 41012-41021 Negative_regulation denotes exclusive
T14466 41012-41021 Negative_regulation denotes exclusive
T14467 41012-41021 Negative_regulation denotes exclusive
T14468 41012-41021 Negative_regulation denotes exclusive
T14469 41068-41072 Protein denotes LMP1
T14470 41141-41151 Positive_regulation denotes activation
T14489 41555-41566 Positive_regulation denotes upregulated
T14490 41570-41574 Protein denotes LMP1
T14491 41594-41599 Protein denotes FoxO1
T14492 41683-41687 Protein denotes LMP1
T14493 41856-41861 Protein denotes Stat3
T14494 41873-41882 Negative_regulation denotes decreased
T14495 41883-41886 Protein denotes p27
T14496 41902-41905 Protein denotes Akt
T14497 42026-42029 Protein denotes Akt
T14498 42041-42046 Protein denotes Stat3
T14499 42153-42157 Protein denotes LMP1
T14500 42301-42305 Protein denotes LMP1
T14501 42468-42472 Protein denotes LMP1
T24790 30558-30563 Protein denotes Stat3
T24791 30739-30743 Protein denotes LMP1
T24792 30796-30800 Protein denotes LMP1
T24793 30859-30863 Protein denotes LMP1
T25228 30934-30937 Protein denotes Akt
T25229 30949-30954 Protein denotes Stat3
T25230 31068-31072 Protein denotes LMP1
T25231 31098-31101 Protein denotes Akt
T4067 9020-9024 Protein denotes LMP1
T4068 9099-9103 Protein denotes LMP1
T4069 9198-9202 Protein denotes LMP1
T4070 9203-9213 Gene_expression denotes expression
T4071 9455-9459 Protein denotes LMP1
T4072 9493-9497 Protein denotes LMP1
T4073 9621-9625 Protein denotes LMP1
T4074 9786-9789 Protein denotes CD5
T4075 9802-9805 Protein denotes CD5
T4076 9923-9926 Protein denotes CD5
T4077 9952-9956 Protein denotes LMP1
T4078 10004-10007 Protein denotes CD5
T4079 10323-10327 Protein denotes LMP1
T4080 10419-10423 Protein denotes CD19
T4081 10424-10427 Protein denotes CD5
T4082 10459-10463 Protein denotes CD19
T4083 10464-10467 Protein denotes CD5
T4084 10487-10491 Protein denotes LMP1
T4085 11723-11727 Protein denotes LMP1
T4086 11889-11893 Protein denotes LMP1
T4087 12526-12530 Protein denotes LMP1
T4088 12917-12927 Gene_expression denotes expression
T4089 12931-12935 Protein denotes LMP1
T688 2641-2666 Protein denotes Latent membrane protein 1
T689 2668-2672 Protein denotes LMP1
T690 2792-2801 Gene_expression denotes expressed
T691 2879-2883 Protein denotes LMP1
T692 2891-2895 Protein denotes CD40
T693 2916-2920 Protein denotes LMP1
T694 2925-2929 Protein denotes CD40
T695 2997-3001 Protein denotes CD40
T696 3002-3011 Binding denotes interacts
T697 3017-3028 Protein denotes CD40 ligand
T698 3029-3038 Gene_expression denotes expressed
T699 3109-3113 Protein denotes LMP1
T700 3171-3186 Binding denotes oligomerization
T701 3188-3192 Protein denotes LMP1
T702 3197-3201 Protein denotes CD40
T703 3202-3210 Binding denotes interact
T704 3202-3210 Binding denotes interact
T705 3225-3246 Protein denotes tumor necrosis factor
T762 5815-5819 Protein denotes LMP1
T763 5878-5881 Protein denotes IL4
T764 5953-5960 Negative_regulation denotes absence
T765 5964-5973 Positive_regulation denotes activated
T766 5974-5979 Protein denotes Stat6
T767 5985-5988 Protein denotes IL4
T768 5989-5995 Regulation denotes target
T769 6051-6061 Positive_regulation denotes activation
T770 6065-6070 Protein denotes Stat3
T771 6095-6097 Protein denotes Rb
T772 6141-6144 Protein denotes Akt
T773 6156-6161 Protein denotes Stat3
T774 6217-6221 Protein denotes LMP1
T775 6380-6391 Regulation denotes deregulated true true
T776 6380-6391 Regulation denotes deregulated true true
T777 6497-6501 Protein denotes LMP1
T778 6585-6588 Protein denotes Akt
T779 6600-6605 Protein denotes Stat3
T24344 25723-25727 Protein denotes LMP1
T24345 25738-25741 Protein denotes Akt
T24346 25772-25774 Protein denotes Rb
T24347 25845-25849 Protein denotes CD19
T24348 25879-25883 Protein denotes LMP1
T24349 25904-25907 Protein denotes Akt
T24350 25945-25949 Protein denotes pAkt
T24351 25965-25972 Regulation denotes targets
T24352 25965-25972 Regulation denotes targets
T24353 25984-25995 Positive_regulation denotes inactivated true true
T24354 25984-25995 Positive_regulation denotes inactivated true true
T24355 25996-26002 Protein denotes pGSK3α
T24356 26003-26004 Protein denotes β
T24357 26014-26023 Positive_regulation denotes activated true
T24358 26024-26030 Protein denotes p-mTOR
T24359 26052-26057 Protein denotes FoxO1
T24360 26112-26116 Protein denotes GSK3
T24361 26252-26254 Protein denotes Rb
T24362 26276-26285 Positive_regulation denotes activated true
T24363 26286-26289 Protein denotes pRb
T24364 26311-26315 Protein denotes Cdk2
T24365 26338-26341 Protein denotes p27
T24777 30201-30204 Protein denotes Akt
T24778 30216-30221 Protein denotes Stat3
T24779 30347-30351 Protein denotes LMP1
T24780 30387-30391 Protein denotes LMP1
T24781 30458-30468 Negative_regulation denotes inhibitors
T24782 30458-30468 Negative_regulation denotes inhibitors
T24783 30458-30468 Negative_regulation denotes inhibitors
T24784 30458-30468 Negative_regulation denotes inhibitors
T24785 30458-30468 Negative_regulation denotes inhibitors
T24786 30486-30490 Protein denotes mTOR
T24787 30504-30507 Protein denotes Akt
T24788 30523-30527 Protein denotes MEK1
T24789 30528-30529 Protein denotes 2
T11740 28571-28575 Protein denotes LMP1
T11741 28633-28636 Protein denotes Akt
T11742 28648-28653 Protein denotes Stat3
T11743 28743-28747 Protein denotes LMP1
T11744 28798-28802 Protein denotes LMP1
T11745 28852-28862 Negative_regulation denotes inhibitors
T11746 28852-28862 Negative_regulation denotes inhibitors
T11747 28852-28862 Negative_regulation denotes inhibitors
T11748 28867-28870 Protein denotes Akt
T11749 28878-28883 Protein denotes Stat3
T11750 28885-28889 Protein denotes mTOR
T11751 29103-29107 Protein denotes LMP1
T11752 29319-29327 Negative_regulation denotes inhibits
T11753 29332-29342 Positive_regulation denotes activation
T11754 29346-29349 Protein denotes Akt
T11755 29432-29435 Protein denotes Akt
T11756 29583-29593 Positive_regulation denotes activation
T11757 29597-29600 Protein denotes Akt
T11758 29644-29648 Protein denotes LMP1
T11790 31979-31983 Protein denotes LMP1
T11791 32046-32053 Regulation denotes effects true true
T11775 30074-30077 Protein denotes Akt
T11776 30087-30090 Protein denotes Akt
T11777 30091-30101 Positive_regulation denotes activation
T11778 31595-31599 Protein denotes LMP1
T11779 31775-31789 Phosphorylation denotes Phosphorylated
T11780 31775-31789 Phosphorylation denotes Phosphorylated
T11781 31790-31793 Protein denotes Akt
T11782 31795-31800 Protein denotes Stat3
T11783 31812-31816 Protein denotes IκBα
T11784 31828-31835 Positive_regulation denotes present
T11785 31828-31835 Positive_regulation denotes present
T11786 31828-31835 Positive_regulation denotes present
T11787 31887-31895 Positive_regulation denotes detected true
T11788 31887-31895 Positive_regulation denotes detected true
T11789 31887-31895 Positive_regulation denotes detected true
T11792 32046-32053 Regulation denotes effects true true
T11793 32057-32067 Positive_regulation denotes activation
T11794 32057-32067 Positive_regulation denotes activation
T11795 32071-32074 Protein denotes Akt
T11796 32078-32083 Protein denotes Stat3
T11797 32100-32108 Negative_regulation denotes inhibits
T11798 32109-32119 Positive_regulation denotes activation
T11799 32123-32128 Protein denotes Stat3
T22655 15193-15197 Protein denotes LMP1
T22645 14367-14371 Protein denotes LMP1
T22646 14465-14469 Protein denotes LMP1
T22647 14568-14571 Protein denotes IL4
T22648 14769-14773 Protein denotes LMP1
T22649 14813-14817 Protein denotes LMP1
T22650 14861-14865 Protein denotes CD19
T22651 14897-14901 Protein denotes LMP1
T22652 15006-15009 Protein denotes IL4
T22653 15079-15083 Protein denotes LMP1
T22654 15135-15138 Protein denotes IL4
T6357 9621-9625 Protein denotes LMP1
T6358 17038-17041 Protein denotes IL4
T6359 17046-17051 Protein denotes Stat6
T6360 17085-17088 Protein denotes IL4
T6361 17124-17127 Protein denotes IL4
T6362 17128-17138 Gene_expression denotes expression
T6363 17140-17143 Protein denotes IL4
T6364 17144-17157 Transcription denotes transcription true
T6365 17207-17210 Protein denotes IL4
T6366 17211-17224 Transcription denotes transcription
T6367 17328-17331 Protein denotes IL4
T6368 17332-17345 Transcription denotes transcription true
T6369 17368-17372 Protein denotes CD19
T6370 17443-17447 Protein denotes LMP1
T6371 17504-17509 Protein denotes GAPDH
T6372 17514-17517 Protein denotes L32
T19638 46086-46090 Protein denotes LMP1
T19639 46135-46139 Protein denotes LMP1
T19640 46284-46288 Protein denotes LMP1
T19641 46674-46679 Protein denotes Stat3
T20767 48835-48853 Protein denotes Taq DNA polymerase
T23704 22890-22894 Protein denotes LMP1
T23705 22895-22906 Positive_regulation denotes Upregulates
T23706 22907-22911 Protein denotes IL10
T23707 22912-22922 Gene_expression denotes Expression
T23708 22942-22951 Positive_regulation denotes Activates
T23709 22952-22957 Protein denotes Stat3
T23710 22971-22981 Transcription denotes expression true
T23711 22971-22981 Transcription denotes expression true
T23712 22971-22981 Transcription denotes expression true
T23713 22985-22989 Protein denotes IL10
T23714 22991-22995 Protein denotes IL15
T23715 23001-23005 Protein denotes IFNγ
T23716 23021-23025 Protein denotes LMP1
T23717 23046-23050 Protein denotes CD19
T23718 23278-23281 Protein denotes L32
T23719 23296-23299 Protein denotes L32
T23720 23391-23400 Positive_regulation denotes activated true
T23721 23401-23407 Protein denotes pStat3
T23722 23429-23433 Protein denotes CD19
T23723 23448-23452 Protein denotes LMP1
T23724 23539-23543 Protein denotes IL10
T23725 23572-23576 Protein denotes IL10
T23726 23657-23661 Protein denotes LMP1
T23727 23742-23747 Protein denotes Stat3
T23728 23824-23833 Positive_regulation denotes activated true
T23729 23842-23848 Protein denotes pStat3
T23730 23874-23878 Protein denotes LMP1
T21797 8478-8482 Positive_regulation denotes High
T21798 8483-8487 Protein denotes LMP1
T21799 8488-8498 Gene_expression denotes Expression
T21800 8543-8547 Protein denotes LMP1
T21801 8548-8558 Gene_expression denotes expression
T21802 8611-8615 Protein denotes CD19
T21803 8697-8701 Protein denotes LMP1
T21804 8789-8793 Protein denotes LMP1
T14343 34182-34186 Protein denotes LMP1
T14344 34224-34228 Protein denotes LMP1
T14345 34334-34340 Positive_regulation denotes higher
T14346 34341-34351 Gene_expression denotes expression
T14347 34362-34366 Protein denotes LMP1
T14348 34403-34407 Protein denotes LMP1
T14349 34548-34552 Protein denotes LMP1
T14350 34660-34664 Protein denotes LMP1
T14351 34758-34762 Protein denotes LMP1
T14352 34863-34867 Protein denotes LMP1
T14471 41155-41158 Protein denotes Akt
T14472 41167-41171 Negative_regulation denotes lack
T14473 41175-41180 Protein denotes Fox01
T14474 41216-41220 Protein denotes LMP1
T14475 41221-41228 Regulation denotes affects true
T14476 41229-41233 Protein denotes bcl6
T14477 41264-41271 Regulation denotes pathway
T14478 41273-41283 Regulation denotes regulation
T14479 41273-41283 Regulation denotes regulation
T14480 41354-41357 Protein denotes p27
T14481 41362-41370 Protein denotes CyclinD2
T14482 41427-41431 Negative_regulation denotes loss
T14483 41435-41440 Protein denotes FoxO1
T14484 41441-41451 Gene_expression denotes expression
T14485 41470-41480 Positive_regulation denotes correlated
T14486 41488-41492 Negative_regulation denotes loss
T14487 41496-41499 Protein denotes p27
T14488 41520-41528 Protein denotes CyclinD2
T3156 6684-6695 Positive_regulation denotes High Levels
T3157 6699-6703 Protein denotes LMP1
T3158 6704-6714 Gene_expression denotes Expression
T3159 6759-6763 Protein denotes LMP1
T3160 6764-6774 Gene_expression denotes expression
T3161 6814-6831 Regulation denotes under the control
T3162 6937-6941 Protein denotes LMP1
T3163 6942-6952 Gene_expression denotes expression
T3164 6957-6967 Positive_regulation denotes restricted
T3165 7068-7072 Protein denotes LMP1
T3166 7073-7083 Gene_expression denotes expression
T3167 7193-7197 Protein denotes CD19
T3168 7286-7290 Protein denotes LMP1
T3169 7295-7305 Gene_expression denotes detectable
T3170 7309-7313 Protein denotes LMP1
T3171 7368-7372 Protein denotes LMP1
T3172 7373-7383 Gene_expression denotes expression
T3173 7388-7396 Positive_regulation denotes stronger
T3174 7513-7525 Positive_regulation denotes higher level
T3175 7529-7533 Protein denotes LMP1
T3176 7593-7603 Gene_expression denotes expression true
T3177 7607-7611 Protein denotes LMP1
T3178 7730-7738 Gene_expression denotes detected
T3179 7739-7743 Protein denotes LMP1
T3180 7867-7871 Protein denotes LMP1
T3181 7872-7882 Gene_expression denotes expression
T3182 7906-7912 Positive_regulation denotes strong
T3183 7913-7917 Protein denotes LMP1
T3185 7990-7994 Protein denotes LMP1
T25232 31113-31118 Protein denotes Stat3
T25233 31157-31160 Protein denotes Akt
T25234 31161-31170 Negative_regulation denotes inhibitor
T25235 31228-31233 Protein denotes Stat3
T25236 31234-31244 Negative_regulation denotes inhibitors
T25237 31365-31370 Protein denotes Stat3
T20331 47595-47599 Protein denotes CD19
T20332 48343-48350 Protein denotes Rnase A
T20333 48355-48357 Protein denotes T1
T18286 42576-42580 Protein denotes LMP1
T18287 42729-42733 Protein denotes LMP1
T25507 16951-16955 Protein denotes LMP1
T25508 16956-16966 Gene_expression denotes Transgenic
T21026 49932-49942 Protein denotes peroxidase
T19034 44736-44739 Protein denotes IL4
T19035 44823-44826 Protein denotes IL4
T19036 45151-45154 Protein denotes IL4
T19037 45176-45179 Protein denotes IL4
T18604 43727-43731 Protein denotes CD19
T18605 44082-44086 Protein denotes CD19
T18606 44186-44189 Protein denotes IL4
T18607 44232-44236 Protein denotes IL10
T18608 44274-44278 Protein denotes IL10
T23126 17955-17959 Protein denotes LMP1
T23127 18011-18014 Protein denotes IL4
T23128 18015-18020 Protein denotes Stat6
T23129 18073-18076 Protein denotes IL4
T23130 18105-18109 Protein denotes CD19
T23131 18124-18128 Protein denotes LMP1
T23132 18157-18160 Protein denotes L32
T23133 18165-18170 Protein denotes GAPDH
T23134 18315-18319 Protein denotes LMP1
T23135 18340-18349 Positive_regulation denotes activated true
T23136 18350-18356 Protein denotes pStat6
T23137 18382-18386 Protein denotes CD19
T23138 18465-18468 Protein denotes IL4
T23139 18636-18640 Protein denotes LMP1
T23140 18681-18684 Protein denotes IL4
T23141 18713-18716 Protein denotes IL4
T23142 18807-18811 Protein denotes LMP1
T22099 10554-10558 Protein denotes LMP1
T22100 10673-10677 Protein denotes LMP1
T22101 10718-10722 Protein denotes CD19
T22102 10736-10739 Protein denotes CD5
T22103 10855-10859 Protein denotes LMP1
T22104 10924-10928 Protein denotes LMP1
T22105 11117-11121 Protein denotes LMP1
T22106 11155-11159 Protein denotes CD19
T22107 11160-11163 Protein denotes CD5
T22108 11190-11194 Protein denotes CD19
T22109 11195-11198 Protein denotes CD5
T22110 11332-11336 Protein denotes LMP1
T22111 11436-11440 Protein denotes CD19
T22112 11464-11468 Protein denotes LMP1
T5484 13231-13235 Protein denotes LMP1
T5485 13343-13346 Protein denotes IL4
T5486 13620-13623 Protein denotes IL4
T5487 13633-13637 Negative_regulation denotes lack
T5488 13641-13645 Protein denotes CD40
T5489 13646-13654 Binding denotes ligation
T5490 13681-13685 Protein denotes LMP1
T5491 13735-13742 Negative_regulation denotes absence
T5492 13746-13749 Protein denotes IL4
T5493 13795-13798 Protein denotes IL4
T5494 13814-13818 Protein denotes LMP1
T5495 13889-13896 Negative_regulation denotes absence
T5496 13900-13903 Protein denotes IL4
T5497 13921-13925 Protein denotes LMP1
T5498 15289-15293 Protein denotes CD19
T5499 15345-15349 Protein denotes LMP1
T5500 15414-15418 Protein denotes LMP1
T5501 15493-15497 Protein denotes LMP1
T5502 15582-15585 Protein denotes IL4
T5503 15651-15654 Protein denotes IL4
T5504 15727-15731 Protein denotes LMP1
T5505 15777-15780 Protein denotes IL4
T5506 15876-15879 Protein denotes IL4
T5507 15942-15946 Protein denotes LMP1
T5508 15983-15993 Gene_expression denotes expression
T5509 15997-16001 Protein denotes LMP1
T5510 16096-16100 Protein denotes LMP1
T5511 16101-16111 Gene_expression denotes expression
T5512 16311-16315 Protein denotes LMP1
T5513 16443-16447 Protein denotes LMP1
T5514 16448-16456 Negative_regulation denotes negative
T5515 16551-16558 Gene_expression denotes express
T5516 16564-16568 Positive_regulation denotes high
T5517 16579-16583 Protein denotes LMP1
T5518 16591-16595 Protein denotes LMP1
T5519 16604-16607 Positive_regulation denotes low true
T5520 16618-16622 Protein denotes LMP1
T5521 16637-16641 Protein denotes LMP1
T5522 16681-16685 Protein denotes LMP1
T5523 16794-16797 Protein denotes IL4
T5524 16823-16826 Protein denotes IL4
T9664 24399-24403 Protein denotes LMP1
T9665 24414-24417 Protein denotes Akt
T9666 24448-24450 Protein denotes Rb
T9667 24470-24474 Protein denotes LMP1
T9668 24512-24520 Positive_regulation denotes requires
T9669 24521-24531 Positive_regulation denotes activation
T9670 24544-24547 Protein denotes Akt
T9671 24567-24576 Positive_regulation denotes activated
T9672 24577-24581 Protein denotes pAkt
T9673 24693-24696 Protein denotes Akt
T9674 24723-24727 Protein denotes LMP1
T9675 24745-24749 Protein denotes pAkt
T9676 24820-24824 Protein denotes CD19
T9677 24849-24853 Protein denotes LMP1
T9678 24877-24886 Positive_regulation denotes increased
T9679 24897-24901 Protein denotes pAkt
T9748 28032-28036 Protein denotes CD19
T9749 28061-28065 Protein denotes LMP1
T9750 28089-28097 Positive_regulation denotes enhanced
T9751 28089-28097 Positive_regulation denotes enhanced
T9752 28108-28111 Protein denotes pRb
T9753 28152-28154 Protein denotes Rb
T9754 28166-28170 Protein denotes Cdk2
T9755 28266-28270 Protein denotes LMP1
T9756 28297-28300 Positive_regulation denotes led
T9757 28304-28313 Positive_regulation denotes increased
T9758 28324-28326 Protein denotes Rb
T9759 28344-28355 Positive_regulation denotes high levels
T9760 28359-28363 Protein denotes Cdk2
T9761 28369-28378 Negative_regulation denotes decreased
T9762 28389-28392 Protein denotes p27
T9763 28435-28437 Protein denotes Rb
T9764 28464-28468 Protein denotes LMP1
T9765 28537-28541 Negative_regulation denotes loss
T9766 28545-28550 Protein denotes FoxO1
T9767 28555-28564 Negative_regulation denotes decreased
T9768 28565-28568 Protein denotes p27
T7421 19637-19641 Protein denotes LMP1
T7422 19642-19653 Positive_regulation denotes Upregulates
T7423 19654-19658 Protein denotes IL10
T7424 19678-19687 Positive_regulation denotes Activates
T7425 19688-19693 Protein denotes Stat3
T7426 19850-19854 Protein denotes CD19
T7427 19906-19909 Protein denotes IL4
T7428 19911-19914 Protein denotes IL5
T7429 19916-19920 Protein denotes IL10
T7430 19922-19926 Protein denotes IL13
T7431 19928-19932 Protein denotes IL15
T7432 19934-19937 Protein denotes IL9
T7507 21926-21930 Protein denotes IL10
T7508 22014-22022 Regulation denotes affected true
T7509 22026-22030 Protein denotes LMP1
T7510 22032-22044 Negative_regulation denotes Neutralizing
T7511 22059-22063 Protein denotes IL10
T7512 22185-22195 Positive_regulation denotes activation true
T7513 22199-22204 Protein denotes Stat3
T7514 22282-22286 Protein denotes IL10
T7515 22312-22318 Protein denotes pStat3
T7516 22335-22344 Positive_regulation denotes activated
T7517 22391-22395 Protein denotes LMP1
T7518 22452-22456 Protein denotes IL10
T7519 22457-22465 Positive_regulation denotes enhanced
T7520 22466-22472 Protein denotes pStat3
T7521 22473-22483 Positive_regulation denotes activation
T7522 22560-22564 Protein denotes IL10
T7523 22650-22655 Protein denotes Stat3
T7524 22656-22666 Positive_regulation denotes activation
T7525 22686-22694 Positive_regulation denotes enhanced true
T7526 22698-22702 Protein denotes IL10
T7527 22718-22737 Negative_regulation denotes neutralizing effect
T7528 22750-22754 Protein denotes IL10
T7529 22799-22803 Protein denotes IL10
T7530 22814-22818 Protein denotes IL10
T7531 23916-23923 Entity denotes Nuclear
T7532 23924-23937 Localization denotes translocation
T7533 23941-23947 Protein denotes pStat3
T7534 23953-23964 Positive_regulation denotes consequence
T7535 23968-23978 Positive_regulation denotes activation
T7536 23984-23991 Entity denotes nuclear
T7537 23992-23998 Protein denotes pStat3
T7538 24007-24015 Localization denotes detected true
T7539 24096-24103 Entity denotes nuclear
T7540 24104-24110 Protein denotes pStat3
T7541 24115-24125 Localization denotes detectable
T7542 24129-24133 Protein denotes LMP1
T7543 24182-24190 Localization denotes detected
T7544 24213-24217 Protein denotes LMP1
T7545 24269-24279 Positive_regulation denotes activation
T7546 24269-24279 Positive_regulation denotes activation
T7547 24283-24289 Protein denotes pStat3
T7548 24311-24316 Protein denotes Stat3
T7549 24331-24336 Protein denotes Stat3
T7550 24362-24366 Protein denotes LMP1
T38 4-29 Protein denotes Latent Membrane Protein 1
T39 30-39 Positive_regulation denotes Activates
T40 30-39 Positive_regulation denotes Activates
T41 40-43 Protein denotes Akt
T42 55-60 Protein denotes Stat3
T43 141-166 Protein denotes Latent membrane protein 1
T44 168-172 Protein denotes LMP1
T45 248-252 Protein denotes LMP1
T46 500-510 Negative_regulation denotes inhibitors
T47 500-510 Negative_regulation denotes inhibitors
T48 514-517 Protein denotes Akt
T49 529-534 Protein denotes Stat3
T50 567-571 Protein denotes LMP1
T51 658-661 Protein denotes IL4
T52 662-667 Protein denotes Stat6
T53 744-749 Protein denotes Stat3
T54 789-800 Regulation denotes deregulated true
T55 789-800 Regulation denotes deregulated true
T56 789-800 Regulation denotes deregulated true
T21427 50409-50413 Protein denotes CD19
T21428 50459-50463 Protein denotes LMP1
T21429 50508-50510 Protein denotes Rb
T21430 50531-50535 Protein denotes Cdk2
T21431 50618-50621 Protein denotes CD5
T21432 50678-50682 Protein denotes LMP1
T21433 50757-50761 Protein denotes pAkt
T21434 50777-50783 Protein denotes pGSK3α
T21435 50784-50785 Protein denotes β
T21436 50802-50808 Protein denotes pStat3
T21437 50824-50830 Protein denotes pStat6
T21438 50846-50851 Protein denotes pmTOR
T21439 50868-50873 Protein denotes Stat6
T21440 50880-50883 Protein denotes Akt
T21441 50890-50895 Protein denotes FoxO1
T21442 50906-50909 Protein denotes p27
T21443 50958-50963 Protein denotes Stat3
T21444 50978-50982 Protein denotes IκBα
T21445 51005-51012 Protein denotes β actin
T21446 51083-51087 Protein denotes GSK3
T21447 51142-51145 Protein denotes pRb
R10825 T14413 T14412 themeOf Akt,activation
R10826 T14414 T14411 themeOf activation,induces
R10827 T14415 T14414 themeOf cRel,activation
R10828 T14416 T14417 causeOf CD40,induces
R10829 T14418 T14417 themeOf downregulation,induces
R10830 T14419 T14418 themeOf p27,downregulation
R10831 T14422 T14421 themeOf p27,decreased
R10832 T14424 T14423 themeOf Rb,phosphorylation
R10833 T14426 T14425 themeOf Cdk2,increased
R10834 T14430 T14431 themeOf Akt,activation
R10835 T14431 T14429 themeOf activation,requirement
R10836 T14432 T14433 themeOf Akt,inhibitor
R10837 T14434 T14437 causeOf activated,lead
R10838 T14434 T14436 causeOf activated,lead
R10839 T14435 T14434 themeOf pAkt,activated
R10840 T14438 T14437 themeOf phosphorylation,lead
R10841 T14439 T14436 themeOf inactivation,lead
R10842 T14440 T14438 themeOf GSK3,phosphorylation
R10843 T14440 T14439 themeOf GSK3,inactivation
R10844 T14444 T14443 themeOf activated,absence
R10845 T14445 T14444 themeOf p-mTOR,activated
R10846 T14446 T14447 causeOf Akt,target
R10847 T14448 T14447 themeOf inhibition,target
R10848 T14449 T14448 themeOf Fox01,inhibition
R10850 T14451 T14450 themeOf FoxO1,Repression
R10878 T14495 T14494 themeOf p27,decreased
R497 T745 T733 partOf 2 domains,LMP1
R498 T747 T748 themeOf LMP1,expressed
R499 T748 T749 themeOf expressed,under the control
R500 T752 T751 themeOf LMP1,express
R5660 T7432 T7442 themeOf IL9,detected
R5661 T7433 T7443 themeOf IL2,detected
R5662 T7434 T7445 themeOf IL6,detected
R5663 T7435 T7439 themeOf IFNγ,detected
R5664 T7447 T7454 themeOf Transcription,higher
R5665 T7448 T7456 themeOf Transcription,higher
R5666 T7449 T7455 themeOf Transcription,higher
R5667 T7450 T7449 themeOf IL10,Transcription
R5668 T7451 T7448 themeOf IL15,Transcription
R5669 T7452 T7447 themeOf IFNγ,Transcription
R5670 T7459 T7457 themeOf IL15,expression
R5671 T7460 T7458 themeOf IFNγ,expression
R5672 T7463 T7468 themeOf upregulation,induced
R5673 T7464 T7467 themeOf upregulation,induced
R5674 T7465 T7463 themeOf IL15,upregulation
R5675 T7466 T7464 themeOf IFNγ,upregulation
R5676 T7469 T7470 themeOf LMP1,expression
R5677 T7470 T7468 causeOf expression,induced
R5678 T7470 T7467 causeOf expression,induced
R5679 T7471 T7472 themeOf IL10,increased
R5680 T7477 T7476 themeOf IL15,Production
R5681 T7478 T7475 themeOf IFNγ,Production
R5682 T7480 T7479 themeOf IL10,upregulation
R5683 T7481 T7482 themeOf IL10,upregulation
R5684 T7486 T7485 themeOf phosphorylated,increased
R5685 T7488 T7486 themeOf Stat3,phosphorylated
R5686 T7488 T7487 themeOf Stat3,activated
R5687 T7488 T7489 themeOf Stat3,target
R5688 T7492 T7493 themeOf IL10,induction
R5689 T7493 T7491 causeOf induction,correlation
R5690 T7494 T7495 themeOf Stat3,activation
R5691 T7495 T7491 themeOf activation,correlation
R5692 T7496 T7498 themeOf activation,induced
R5693 T7497 T7496 themeOf Stat3,activation
R5694 T7499 T7498 causeOf IL10,induced
R5695 T7502 T7503 themeOf LMP1,expression
R5696 T7503 T7501 causeOf expression,correlation
R5697 T7504 T7505 themeOf IL10,induction
R5698 T7505 T7501 themeOf induction,correlation
R5699 T7506 T7508 themeOf induction,affected
R5700 T7507 T7506 themeOf IL10,induction
R5701 T7509 T7508 causeOf LMP1,affected
R5702 T7511 T7510 themeOf IL10,Neutralizing
R5703 T7513 T7512 themeOf Stat3,activation
R5704 T7515 T7516 themeOf pStat3,activated
R5705 T7518 T7519 causeOf IL10,enhanced
R5706 T7520 T7521 themeOf pStat3,activation
R5707 T7521 T7519 themeOf activation,enhanced
R5708 T7523 T7524 themeOf Stat3,activation
R5709 T7524 T7525 themeOf activation,enhanced
R5710 T7528 T7527 themeOf IL10,neutralizing effect
R5711 T7531 T7532 locationOf Nuclear,translocation
R5712 T7532 T7534 themeOf translocation,consequence
R5713 T7533 T7532 themeOf pStat3,translocation
R5714 T7533 T7535 themeOf pStat3,activation
R5715 T7535 T7534 causeOf activation,consequence
R5716 T7536 T7538 locationOf nuclear,detected
R5717 T7537 T7538 themeOf pStat3,detected
R5718 T7539 T7541 locationOf nuclear,detectable
R5719 T7539 T7543 locationOf nuclear,detected
R5720 T7540 T7541 themeOf pStat3,detectable
R5721 T7540 T7543 themeOf pStat3,detected
R5722 T7547 T7545 themeOf pStat3,activation
R7372 T9714 T9715 causeOf LMP1,induced
R7373 T9715 T9713 causeOf induced,affected
R7374 T9716 T9717 themeOf Akt,activation
R7375 T9717 T9715 themeOf activation,induced
R7376 T9721 T9720 themeOf FoxO1,targets
R7377 T9724 T9725 themeOf FoxO1,decreased
R7378 T9728 T9729 themeOf Akt,activation
R7379 T9729 T9730 causeOf activation,induce
R7380 T9731 T9732 themeOf FoxO1,degradation
R7381 T9732 T9730 themeOf degradation,induce
R7382 T9734 T9735 causeOf Akt,regulator
R7383 T9736 T9735 themeOf FoxO1,regulator
R7384 T9738 T9737 themeOf p27,expression
R7385 T9752 T9750 themeOf pRb,enhanced
R7386 T9754 T9751 themeOf Cdk2,enhanced
R7387 T9757 T9756 themeOf increased,led
R7388 T9758 T9757 themeOf Rb,increased
R7389 T9760 T9759 themeOf Cdk2,high levels
R7390 T9762 T9761 themeOf p27,decreased
R7391 T9766 T9765 themeOf FoxO1,loss
R7392 T9768 T9767 themeOf p27,decreased
R8852 T11779 T11788 themeOf Phosphorylated,detected
R8853 T11780 T11784 themeOf Phosphorylated,present
R8854 T11780 T11789 themeOf Phosphorylated,detected
R8855 T11781 T11780 themeOf Akt,Phosphorylated
R8856 T11782 T11779 themeOf Stat3,Phosphorylated
R8857 T11783 T11786 themeOf IκBα,present
R8858 T11783 T11787 themeOf IκBα,detected
R8859 T11793 T11792 themeOf activation,effects
R8860 T11794 T11791 themeOf activation,effects
R8861 T11795 T11794 themeOf Akt,activation
R8862 T11796 T11793 themeOf Stat3,activation
R8863 T11798 T11797 themeOf activation,inhibits
R8864 T11799 T11798 themeOf Stat3,activation
R8865 T11802 T11801 themeOf Stat3,activated
R8866 T11806 T11804 themeOf Akt,Phosphorylated
R8867 T11806 T11810 themeOf Akt,detectable
R8868 T11806 T11814 themeOf Akt,decreased
R8869 T11807 T11805 themeOf Stat3,Phosphorylated
R8870 T11807 T11809 themeOf Stat3,detectable
R8871 T11807 T11813 themeOf Stat3,decreased
R8872 T11808 T11811 themeOf IκBα,detectable
R8873 T11808 T11812 themeOf IκBα,decreased
R8874 T11816 T11815 themeOf Stat3,inhibitor
R8875 T11819 T11820 themeOf IκBα,affected
R8876 T11822 T11821 themeOf Stat3,inhibition
R8877 T11824 T11825 themeOf Stat3,inhibition
R8878 T11831 T11830 themeOf MEK1,inhibitor
R8879 T11832 T11829 themeOf 2,inhibitor
R8880 T11838 T11837 themeOf mTOR,inhibitor
R8881 T11839 T11840 themeOf mTOR,targeted
R19225 T24787 T24783 themeOf Akt,inhibitors
R19226 T24788 T24782 themeOf MEK1,inhibitors
R19227 T24789 T24781 themeOf 2,inhibitors
R19228 T24790 T24785 themeOf Stat3,inhibitors
R3147 T4069 T4070 themeOf LMP1,expression
R3148 T4089 T4088 themeOf LMP1,expression
R468 T699 T700 themeOf LMP1,oligomerization
R469 T701 T704 themeOf LMP1,interact
R470 T702 T703 themeOf CD40,interact
R471 T710 T711 themeOf CD40,ligation
R472 T716 T715 themeOf CD40,deficient
R473 T717 T714 themeOf CD40L,deficient
R474 T718 T722 themeOf membrane proximal,bind
R475 T718 T720 partOf membrane proximal,CD40
R476 T719 T724 themeOf distal cytoplasmic regions,bind
R477 T719 T720 partOf distal cytoplasmic regions,CD40
R478 T719 T723 themeOf distal cytoplasmic regions,bind
R479 T719 T721 themeOf distal cytoplasmic regions,bind
R480 T725 T722 themeOf TRAF6,bind
R481 T726 T724 themeOf TRAFs2,bind
R482 T727 T723 themeOf 3,bind
R483 T728 T721 themeOf 5,bind
R484 T731 T732 themeOf CD40,deficient
R485 T732 T730 themeOf deficient,rescue
R486 T739 T735 themeOf TRAFs 1,recruits
R487 T740 T738 themeOf 2,recruits
R488 T741 T737 themeOf 3,recruits
R489 T742 T734 themeOf 5,recruits
R490 T743 T736 themeOf TRAF6,recruits
R491 T744 T735 themeOf C-terminal activation regions 1,recruits
R492 T744 T733 partOf C-terminal activation regions 1,LMP1
R493 T744 T738 themeOf C-terminal activation regions 1,recruits
R494 T744 T737 themeOf C-terminal activation regions 1,recruits
R495 T744 T734 themeOf C-terminal activation regions 1,recruits
R496 T745 T736 themeOf 2 domains,recruits
R463 T688 T690 themeOf Latent membrane protein 1,expressed
R464 T689 T688 equivalentTo LMP1,Latent membrane protein 1
R465 T695 T696 themeOf CD40,interacts
R466 T697 T696 themeOf CD40 ligand,interacts
R467 T697 T698 themeOf CD40 ligand,expressed
R501 T756 T755 themeOf Akt,activated
R502 T758 T757 themeOf cRel,activation
R503 T765 T764 themeOf activated,absence
R504 T766 T765 themeOf Stat6,activated
R505 T766 T768 themeOf Stat6,target
R506 T767 T768 causeOf IL4,target
R507 T770 T769 themeOf Stat3,activation
R508 T772 T775 themeOf Akt,deregulated
R509 T773 T776 themeOf Stat3,deregulated
R18934 T24355 T24351 themeOf pGSK3α,targets
R18935 T24355 T24354 themeOf pGSK3α,inactivated
R18936 T24356 T24352 themeOf β,targets
R18937 T24356 T24353 themeOf β,inactivated
R18938 T24358 T24357 themeOf p-mTOR,activated
R18939 T24363 T24362 themeOf pRb,activated
R19224 T24786 T24784 themeOf mTOR,inhibitors
R8835 T11748 T11746 themeOf Akt,inhibitors
R8836 T11749 T11747 themeOf Stat3,inhibitors
R8837 T11750 T11745 themeOf mTOR,inhibitors
R8838 T11753 T11752 themeOf activation,inhibits
R8839 T11754 T11753 themeOf Akt,activation
R8840 T11757 T11756 themeOf Akt,activation
R8841 T11761 T11759 themeOf Akt,phosphorylated
R8842 T11762 T11760 themeOf Stat3,phosphorylated
R8843 T11765 T11764 themeOf phosphorylation,blocked
R8844 T11766 T11765 themeOf Akt,phosphorylation
R8845 T11767 T11769 themeOf phosphorylated,detected
R8846 T11768 T11767 themeOf Akt,phosphorylated
R8847 T11772 T11771 themeOf Stat3,Phosphorylated
R8848 T11773 T11770 themeOf IκBα,Phosphorylated
R8849 T11775 T11774 themeOf Akt,targets
R8850 T11776 T11777 themeOf Akt,activation
R8851 T11779 T11785 themeOf Phosphorylated,present
R4888 T6361 T6362 themeOf IL4,expression
R4889 T6363 T6364 themeOf IL4,transcription
R4890 T6365 T6366 themeOf IL4,transcription
R4891 T6367 T6368 themeOf IL4,transcription
R4892 T6374 T6373 themeOf Stat6,Activated
R4893 T6374 T6376 themeOf Stat6,target
R4894 T6375 T6374 equivalentTo pStat6,Stat6
R4895 T6380 T6381 causeOf IL4,induced
R4896 T6382 T6383 themeOf Stat6,phosphorylation
R4897 T6383 T6381 themeOf phosphorylation,induced
R18460 T23704 T23705 causeOf LMP1,Upregulates
R18461 T23704 T23708 causeOf LMP1,Activates
R18462 T23706 T23707 themeOf IL10,Expression
R18463 T23707 T23705 themeOf Expression,Upregulates
R18464 T23709 T23708 themeOf Stat3,Activates
R18465 T23713 T23710 themeOf IL10,expression
R18466 T23714 T23712 themeOf IL15,expression
R18467 T23715 T23711 themeOf IFNγ,expression
R18468 T23721 T23720 themeOf pStat3,activated
R18469 T23729 T23728 themeOf pStat3,activated
R17034 T21798 T21799 themeOf LMP1,Expression
R17035 T21799 T21797 themeOf Expression,High
R17036 T21800 T21801 themeOf LMP1,expression
R10804 T14367 T14368 themeOf LMP1,expressed
R10805 T14370 T14369 themeOf expression,elevated
R10806 T14371 T14370 themeOf LMP1,expression
R10807 T14375 T14374 themeOf IL10,upregulation
R10808 T14380 T14379 themeOf IL10,Induction
R10809 T14381 T14382 causeOf LMP1,stimulate
R10810 T14383 T14384 themeOf IL10,expression
R10811 T14384 T14382 themeOf expression,stimulate
R10812 T14385 T14386 themeOf Stat3,activated
R10813 T14387 T14389 causeOf induction,enhance
R10814 T14388 T14387 themeOf IL10,induction
R10815 T14390 T14391 themeOf Stat3,activation
R10816 T14391 T14389 themeOf activation,enhance
R10817 T14399 T14398 themeOf cRel,deficient
R10818 T14400 T14397 themeOf p85,deficient
R10819 T14401 T14402 themeOf CD40,ligation
R10820 T14403 T14404 themeOf cRel,activated
R10821 T14407 T14406 themeOf cRel,activation
R10822 T14409 T14410 causeOf LMP1,induces
R10823 T14409 T14411 causeOf LMP1,induces
R10824 T14412 T14410 themeOf activation,induces
R10800 T14346 T14345 themeOf expression,higher
R10801 T14347 T14346 themeOf LMP1,expression
R10802 T14354 T14355 themeOf CD40,deficient
R10803 T14359 T14358 themeOf LMP1,expression
R10849 T14450 T14452 causeOf Repression,inhibit
R10851 T14453 T14452 themeOf expression,inhibit
R10852 T14454 T14453 themeOf bcl6,expression
R10853 T14460 T14459 themeOf bcl6,downregulation
R10854 T14461 T14466 themeOf expression,exclusive
R10855 T14461 T14466 causeOf expression,exclusive
R10856 T14461 T14465 themeOf expression,exclusive
R10857 T14461 T14467 causeOf expression,exclusive
R10858 T14462 T14465 causeOf expression,exclusive
R10859 T14462 T14467 themeOf expression,exclusive
R10860 T14462 T14468 themeOf expression,exclusive
R10861 T14462 T14468 causeOf expression,exclusive
R10862 T14463 T14461 themeOf LMP1,expression
R10863 T14464 T14462 themeOf bcl6,expression
R10864 T14471 T14470 themeOf Akt,activation
R10865 T14473 T14472 themeOf Fox01,lack
R10866 T14473 T14477 themeOf Fox01,pathway
R10867 T14474 T14477 causeOf LMP1,pathway
R10868 T14476 T14475 themeOf bcl6,affects
R10869 T14477 T14475 causeOf pathway,affects
R10870 T14480 T14478 themeOf p27,regulation
R10871 T14481 T14479 themeOf CyclinD2,regulation
R10872 T14482 T14485 causeOf loss,correlated
R10873 T14483 T14484 themeOf FoxO1,expression
R10874 T14484 T14482 themeOf expression,loss
R10875 T14486 T14485 themeOf loss,correlated
R10876 T14487 T14486 themeOf p27,loss
R10877 T14488 T14489 themeOf CyclinD2,upregulated
R19561 T25233 T25234 themeOf Akt,inhibitor
R19562 T25235 T25236 themeOf Stat3,inhibitors
R2444 T3157 T3158 themeOf LMP1,Expression
R2445 T3158 T3156 themeOf Expression,High Levels
R2446 T3159 T3160 themeOf LMP1,expression
R2447 T3160 T3161 themeOf expression,under the control
R2448 T3162 T3163 themeOf LMP1,expression
R2449 T3163 T3164 themeOf expression,restricted
R2450 T3165 T3166 themeOf LMP1,expression
R2451 T3168 T3169 themeOf LMP1,detectable
R2452 T3171 T3172 themeOf LMP1,expression
R2453 T3172 T3173 themeOf expression,stronger
R2454 T3175 T3174 themeOf LMP1,higher level
R2455 T3177 T3176 themeOf LMP1,expression
R2456 T3179 T3178 themeOf LMP1,detected
R2457 T3180 T3181 themeOf LMP1,expression
R2458 T3183 T3182 themeOf LMP1,strong
R2459 T3185 T3184 themeOf LMP1,weakly
R2460 T3186 T3187 themeOf LMP1,expression
R2461 T3187 T3188 themeOf expression,abundantly
R2462 T3190 T3189 themeOf LMP1,intense
R2463 T3192 T3191 themeOf LMP1,increased
R2464 T3194 T3195 themeOf LMP1,expression
R2465 T3195 T3193 themeOf expression,increase
R2466 T3196 T3197 themeOf expressing,high levels
R2467 T3198 T3196 themeOf LMP1,expressing
R2468 T3200 T3201 themeOf LMP1,expression
R2469 T3201 T3199 themeOf expression,high
R2470 T3203 T3202 themeOf levels,increased
R2471 T3204 T3203 themeOf LMP1,levels
R19768 T25507 T25508 themeOf LMP1,Transgenic
R18036 T23136 T23135 themeOf pStat6,activated
R4312 T5481 T5482 themeOf CD40,ligation
R4313 T5488 T5489 themeOf CD40,ligation
R4314 T5489 T5487 themeOf ligation,lack
R4315 T5492 T5491 themeOf IL4,absence
R4316 T5496 T5495 themeOf IL4,absence
R4317 T5509 T5508 themeOf LMP1,expression
R4318 T5510 T5511 themeOf LMP1,expression
R4319 T5513 T5514 themeOf LMP1,negative
R4320 T5515 T5516 themeOf express,high
R4321 T5515 T5519 themeOf express,low
R4322 T5521 T5515 themeOf LMP1,express
R7355 T9684 T9687 themeOf target,inactivated
R7356 T9685 T9684 themeOf glycogen synthase kinase 3,target
R7358 T9689 T9688 themeOf phosphorylated,increased
R7349 T9669 T9668 themeOf activation,requires
R7350 T9670 T9669 themeOf Akt,activation
R7351 T9672 T9671 themeOf pAkt,activated
R7352 T9679 T9678 themeOf pAkt,increased
R7353 T9682 T9681 themeOf pAkt,increase
R7354 T9683 T9684 themeOf Akt,target
R7357 T9686 T9685 equivalentTo GSK3,glycogen synthase kinase 3
R7359 T9690 T9689 themeOf GSK3,phosphorylated
R7360 T9691 T9692 themeOf GSK3,target
R7361 T9694 T9692 themeOf Akt,target
R7362 T9694 T9693 themeOf Akt,activated
R7363 T9697 T9696 themeOf Akt,activation
R7364 T9699 T9698 themeOf GSK3,phosphorylation
R7365 T9701 T9700 themeOf Akt,activated
R7366 T9703 T9702 themeOf GSK3,phosphorylated
R7367 T9705 T9704 themeOf GSK3,regulation
R7368 T9706 T9707 themeOf Akt,targets
R7369 T9709 T9711 themeOf Activated,increased
R7370 T9709 T9713 themeOf Activated,affected
R7371 T9710 T9709 themeOf p-mTOR,Activated
R5651 T7421 T7422 causeOf LMP1,Upregulates
R5652 T7421 T7424 causeOf LMP1,Activates
R5653 T7423 T7422 themeOf IL10,Upregulates
R5654 T7425 T7424 themeOf Stat3,Activates
R5655 T7427 T7440 themeOf IL4,detected
R5656 T7428 T7441 themeOf IL5,detected
R5657 T7429 T7438 themeOf IL10,detected
R5658 T7430 T7437 themeOf IL13,detected
R5659 T7431 T7444 themeOf IL15,detected
R5723 T7548 T7546 themeOf Stat3,activation
R346 T38 T39 causeOf Latent Membrane Protein 1,Activates
R347 T38 T40 causeOf Latent Membrane Protein 1,Activates
R348 T41 T39 themeOf Akt,Activates
R349 T42 T40 themeOf Stat3,Activates
R350 T48 T47 themeOf Akt,inhibitors
R351 T49 T46 themeOf Stat3,inhibitors
R352 T51 T56 themeOf IL4,deregulated
R353 T52 T54 themeOf Stat6,deregulated
R354 T53 T55 themeOf Stat3,deregulated

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T249 909-912 P31749 denotes Akt
T250 909-912 P31751 denotes Akt
T251 909-912 Q9Y243 denotes Akt
T252 924-929 P40763 denotes Stat3
T1706 2641-2666 P03230 denotes Latent membrane protein 1
T1707 2668-2672 P03230 denotes LMP1
T1708 2879-2883 P03230 denotes LMP1
T1709 2891-2895 P25942 denotes CD40
T1710 2916-2920 P03230 denotes LMP1
T1711 2925-2929 P25942 denotes CD40
T1712 2997-3001 P25942 denotes CD40
T1713 3017-3021 P25942 denotes CD40
T1714 3017-3028 P29965 denotes CD40 ligand
T1715 3109-3113 P03230 denotes LMP1
T1716 3188-3192 P03230 denotes LMP1
T1717 3197-3201 P25942 denotes CD40
T1718 3225-3246 P01375 denotes tumor necrosis factor
T1719 3314-3319 P05412 denotes c-Jun
T1720 3316-3319 P05412 denotes Jun
T1721 3349-3352 O15264 denotes p38
T1722 3349-3352 Q15759 denotes p38
T1723 3349-3352 P53778 denotes p38
T1724 3349-3352 Q16539 denotes p38
T1725 3542-3546 P03230 denotes LMP1
T1726 3599-3602 P31751 denotes Akt
T1727 3599-3602 P31749 denotes Akt
T1728 3599-3602 Q9Y243 denotes Akt
T1729 3654-3658 P03230 denotes LMP1
T1730 3760-3764 P25942 denotes CD40
T1731 3794-3797 P05112 denotes IL4
T1732 3818-3822 P25942 denotes CD40
T1733 3910-3914 P25942 denotes CD40
T1734 3918-3923 P29965 denotes CD40L
T1735 4058-4062 P25942 denotes CD40
T1736 4073-4078 Q9Y4K3 denotes TRAF6
T1737 4287-4291 P03230 denotes LMP1
T1738 4303-4307 P25942 denotes CD40
T1739 4392-4396 P03230 denotes LMP1
T1740 4448-4453 Q9Y4K3 denotes TRAF6
T1741 4537-4541 P03230 denotes LMP1
T1742 4700-4704 P03230 denotes LMP1
T1743 4821-4825 P03230 denotes LMP1
T1744 4859-4863 P03230 denotes LMP1
T1745 5023-5027 P03230 denotes LMP1
T1746 5071-5075 P03230 denotes LMP1
T1747 5130-5133 P31751 denotes Akt
T1748 5130-5133 P31749 denotes Akt
T1749 5130-5133 Q9Y243 denotes Akt
T1750 5140-5143 Q15759 denotes p38
T1751 5140-5143 Q16539 denotes p38
T1752 5140-5143 P53778 denotes p38
T1753 5140-5143 O15264 denotes p38
T1754 5206-5210 Q04864 denotes cRel
T1755 5236-5240 P03230 denotes LMP1
T1756 5684-5688 P03230 denotes LMP1
T1757 5792-5795 P05112 denotes IL4
T1758 5815-5819 P03230 denotes LMP1
T1759 5878-5881 P05112 denotes IL4
T1760 5974-5979 P42226 denotes Stat6
T1761 5985-5988 P05112 denotes IL4
T1762 6065-6070 P40763 denotes Stat3
T1763 6095-6097 P06400 denotes Rb
T1764 6141-6144 Q9Y243 denotes Akt
T1765 6141-6144 P31749 denotes Akt
T1766 6141-6144 P31751 denotes Akt
T1767 6156-6161 P40763 denotes Stat3
T1768 6217-6221 P03230 denotes LMP1
T1769 6497-6501 P03230 denotes LMP1
T1770 6585-6588 Q9Y243 denotes Akt
T1771 6585-6588 P31751 denotes Akt
T1772 6585-6588 P31749 denotes Akt
T1773 6600-6605 P40763 denotes Stat3
T3497 6699-6703 P03230 denotes LMP1
T3498 6759-6763 P03230 denotes LMP1
T3499 6937-6941 P03230 denotes LMP1
T3500 7068-7072 P03230 denotes LMP1
T3501 7193-7197 P15391 denotes CD19
T3502 7286-7290 P03230 denotes LMP1
T3503 7309-7313 P03230 denotes LMP1
T3504 7368-7372 P03230 denotes LMP1
T3505 7529-7533 P03230 denotes LMP1
T3506 7607-7611 P03230 denotes LMP1
T3507 7739-7743 P03230 denotes LMP1
T3508 7867-7871 P03230 denotes LMP1
T3509 7913-7917 P03230 denotes LMP1
T3510 7990-7994 P03230 denotes LMP1
T3511 8026-8030 P03230 denotes LMP1
T3512 8101-8105 P03230 denotes LMP1
T3513 8153-8157 P03230 denotes LMP1
T3514 8236-8240 P03230 denotes LMP1
T3515 8307-8311 P03230 denotes LMP1
T3516 8343-8347 P03230 denotes LMP1
T3517 8462-8466 P03230 denotes LMP1
T4661 9020-9024 P03230 denotes LMP1
T4662 9099-9103 P03230 denotes LMP1
T4663 9198-9202 P03230 denotes LMP1
T4664 9455-9459 P03230 denotes LMP1
T4665 9493-9497 P03230 denotes LMP1
T4666 9621-9625 P03230 denotes LMP1
T4667 9786-9789 P06127 denotes CD5
T4668 9802-9805 P06127 denotes CD5
T6037 13052-13056 P03230 denotes LMP1
T6038 13159-13163 P25942 denotes CD40
T6039 13198-13201 P05112 denotes IL4
T6040 13231-13235 P03230 denotes LMP1
T6041 13343-13346 P05112 denotes IL4
T6042 13620-13623 P05112 denotes IL4
T6043 13641-13645 P25942 denotes CD40
T6044 13681-13685 P03230 denotes LMP1
T6045 13746-13749 P05112 denotes IL4
T6046 13795-13798 P05112 denotes IL4
T6047 13814-13818 P03230 denotes LMP1
T6048 13900-13903 P05112 denotes IL4
T6049 13921-13925 P03230 denotes LMP1
T6050 15289-15293 P15391 denotes CD19
T6051 15345-15349 P03230 denotes LMP1
T6052 15414-15418 P03230 denotes LMP1
T6053 15493-15497 P03230 denotes LMP1
T6054 15582-15585 P05112 denotes IL4
T6055 15651-15654 P05112 denotes IL4
T6056 15727-15731 P03230 denotes LMP1
T6057 15777-15780 P05112 denotes IL4
T6058 15876-15879 P05112 denotes IL4
T6059 15942-15946 P03230 denotes LMP1
T6060 15997-16001 P03230 denotes LMP1
T6061 16096-16100 P03230 denotes LMP1
T6062 16311-16315 P03230 denotes LMP1
T6063 16443-16447 P03230 denotes LMP1
T6064 16579-16583 P03230 denotes LMP1
T6065 16591-16595 P03230 denotes LMP1
T6066 16618-16622 P03230 denotes LMP1
T6067 16637-16641 P03230 denotes LMP1
T6068 16681-16685 P03230 denotes LMP1
T6069 16794-16797 P05112 denotes IL4
T6070 16823-16826 P05112 denotes IL4
T6690 9621-9625 P03230 denotes LMP1
T6691 17038-17041 P05112 denotes IL4
T6692 17046-17051 P42226 denotes Stat6
T6693 17085-17088 P05112 denotes IL4
T6694 17124-17127 P05112 denotes IL4
T6695 17140-17143 P05112 denotes IL4
T6696 17207-17210 P05112 denotes IL4
T6697 17328-17331 P05112 denotes IL4
T6698 17368-17372 P15391 denotes CD19
T6699 17443-17447 P03230 denotes LMP1
T6700 17504-17509 P04406 denotes GAPDH
T6701 17514-17517 P62910 denotes L32
T6702 17514-17517 Q9BYC8 denotes L32
T6703 17577-17582 P42226 denotes Stat6
T6704 17584-17590 P42226 denotes pStat6
T6705 17609-17612 P05112 denotes IL4
T6706 17665-17669 P03230 denotes LMP1
T6707 17719-17725 P42226 denotes pStat6
T6708 17773-17777 P03230 denotes LMP1
T6709 17884-17887 P05112 denotes IL4
T6710 17896-17901 P42226 denotes Stat6
T6711 19044-19047 P05112 denotes IL4
T6712 19288-19291 P05112 denotes IL4
T6713 19357-19360 P05112 denotes IL4
T6714 19419-19422 P05112 denotes IL4
T6715 19458-19462 P03230 denotes LMP1
T6716 19532-19536 P03230 denotes LMP1
T6717 19585-19588 P05112 denotes IL4
T6718 19619-19624 P42226 denotes Stat6
T8201 19637-19641 P03230 denotes LMP1
T8202 19654-19658 P22301 denotes IL10
T8203 19688-19693 P40763 denotes Stat3
T8204 19850-19854 P15391 denotes CD19
T8205 19906-19909 P05112 denotes IL4
T8206 19911-19914 P05113 denotes IL5
T8207 19916-19920 P22301 denotes IL10
T8208 19922-19926 P35225 denotes IL13
T8209 19928-19932 P40933 denotes IL15
T8210 19939-19942 P60568 denotes IL2
T8211 19944-19947 P05231 denotes IL6
T8212 20065-20068 Q9BYC8 denotes L32
T8213 20065-20068 P62910 denotes L32
T8214 20158-20161 P62910 denotes L32
T8215 20158-20161 Q9BYC8 denotes L32
T8216 20239-20243 P22301 denotes IL10
T8217 20245-20249 P40933 denotes IL15
T8218 20290-20294 P03230 denotes LMP1
T8219 20474-20478 P40933 denotes IL15
T8220 20496-20500 P03230 denotes LMP1
T8221 20576-20580 P40933 denotes IL15
T8222 20604-20608 P03230 denotes LMP1
T8223 20710-20714 P22301 denotes IL10
T8224 20803-20807 P03230 denotes LMP1
T8225 20846-20850 P03230 denotes LMP1
T8226 20901-20905 P40933 denotes IL15
T8227 21128-21132 P22301 denotes IL10
T8228 21164-21168 P22301 denotes IL10
T8229 21287-21291 P03230 denotes LMP1
T8230 21333-21337 P03230 denotes LMP1
T8231 21447-21452 P40763 denotes Stat3
T8232 21470-21474 P22301 denotes IL10
T8233 21588-21592 P22301 denotes IL10
T8234 21621-21626 P40763 denotes Stat3
T8235 21676-21681 P40763 denotes Stat3
T8236 21707-21711 P22301 denotes IL10
T8237 21720-21725 P40763 denotes Stat3
T8238 21819-21823 P03230 denotes LMP1
T8239 21853-21857 P22301 denotes IL10
T8240 21926-21930 P22301 denotes IL10
T8241 22026-22030 P03230 denotes LMP1
T8242 22059-22063 P22301 denotes IL10
T8243 22199-22204 P40763 denotes Stat3
T8244 22282-22286 P22301 denotes IL10
T8245 22312-22318 P40763 denotes pStat3
T8246 22391-22395 P03230 denotes LMP1
T8247 22452-22456 P22301 denotes IL10
T8248 22466-22472 P40763 denotes pStat3
T8249 22560-22564 P22301 denotes IL10
T8250 22650-22655 P40763 denotes Stat3
T8251 22698-22702 P22301 denotes IL10
T8252 22750-22754 P22301 denotes IL10
T8253 22799-22803 P22301 denotes IL10
T8254 22814-22818 P22301 denotes IL10
T8255 23941-23947 P40763 denotes pStat3
T8256 23992-23998 P40763 denotes pStat3
T8257 24104-24110 P40763 denotes pStat3
T8258 24129-24133 P03230 denotes LMP1
T8259 24213-24217 P03230 denotes LMP1
T8260 24283-24289 P40763 denotes pStat3
T8261 24311-24316 P40763 denotes Stat3
T8262 24331-24336 P40763 denotes Stat3
T8263 24362-24366 P03230 denotes LMP1
T10395 24399-24403 P03230 denotes LMP1
T10396 24414-24417 P31749 denotes Akt
T10397 24414-24417 P31751 denotes Akt
T10398 24414-24417 Q9Y243 denotes Akt
T10399 24448-24450 P06400 denotes Rb
T10400 24470-24474 P03230 denotes LMP1
T10401 24544-24547 P31749 denotes Akt
T10402 24544-24547 Q9Y243 denotes Akt
T10403 24544-24547 P31751 denotes Akt
T10404 24577-24581 P31751 denotes pAkt
T10405 24577-24581 P31749 denotes pAkt
T10406 24577-24581 Q9Y243 denotes pAkt
T10407 24693-24696 Q9Y243 denotes Akt
T10408 24693-24696 P31749 denotes Akt
T10409 24693-24696 P31751 denotes Akt
T10410 24723-24727 P03230 denotes LMP1
T10411 24745-24749 P31749 denotes pAkt
T10412 24745-24749 Q9Y243 denotes pAkt
T10413 24745-24749 P31751 denotes pAkt
T10414 24820-24824 P15391 denotes CD19
T10415 24849-24853 P03230 denotes LMP1
T10416 24897-24901 P31749 denotes pAkt
T10417 24897-24901 Q9Y243 denotes pAkt
T10418 24897-24901 P31751 denotes pAkt
T10419 24978-24982 P03230 denotes LMP1
T10420 25046-25050 P31751 denotes pAkt
T10421 25046-25050 Q9Y243 denotes pAkt
T10422 25046-25050 P31749 denotes pAkt
T10423 25063-25066 Q9Y243 denotes Akt
T10424 25063-25066 P31751 denotes Akt
T10425 25063-25066 P31749 denotes Akt
T10426 25102-25106 P49841 denotes GSK3
T10427 25102-25106 P49840 denotes GSK3
T10428 25177-25181 P49841 denotes GSK3
T10429 25177-25181 P49840 denotes GSK3
T10430 25316-25320 P49841 denotes GSK3
T10431 25316-25320 P49840 denotes GSK3
T10432 25350-25353 Q9Y243 denotes Akt
T10433 25350-25353 P31749 denotes Akt
T10434 25350-25353 P31751 denotes Akt
T10435 25361-25365 P03230 denotes LMP1
T10436 25434-25437 P31749 denotes Akt
T10437 25434-25437 P31751 denotes Akt
T10438 25434-25437 Q9Y243 denotes Akt
T10439 25465-25469 P49841 denotes GSK3
T10440 25465-25469 P49840 denotes GSK3
T10441 25577-25580 Q9Y243 denotes Akt
T10442 25577-25580 P31749 denotes Akt
T10443 25577-25580 P31751 denotes Akt
T10444 25620-25624 P49841 denotes GSK3
T10445 25620-25624 P49840 denotes GSK3
T10446 25707-25711 P49840 denotes GSK3
T10447 25707-25711 P49841 denotes GSK3
T10448 26410-26413 Q9Y243 denotes Akt
T10449 26410-26413 P31751 denotes Akt
T10450 26410-26413 P31749 denotes Akt
T10451 26449-26453 P42345 denotes mTOR
T10452 26481-26485 P42345 denotes mTOR
T10453 26507-26511 P03230 denotes LMP1
T10454 26602-26606 P03230 denotes LMP1
T10455 26615-26618 P31751 denotes Akt
T10456 26615-26618 P31749 denotes Akt
T10457 26615-26618 Q9Y243 denotes Akt
T10458 26691-26694 P31751 denotes Akt
T10459 26691-26694 P31749 denotes Akt
T10460 26691-26694 Q9Y243 denotes Akt
T10461 26962-26967 Q12778 denotes FoxO1
T10462 26998-27003 Q12778 denotes FoxO1
T10463 27043-27048 Q12778 denotes FoxO1
T10464 27084-27089 Q12778 denotes FoxO1
T10465 27139-27144 Q12778 denotes FoxO1
T10466 27192-27196 P03230 denotes LMP1
T10467 27318-27321 P31749 denotes Akt
T10468 27318-27321 Q9Y243 denotes Akt
T10469 27318-27321 P31751 denotes Akt
T10470 27373-27376 P31751 denotes Akt
T10471 27373-27376 P31749 denotes Akt
T10472 27373-27376 Q9Y243 denotes Akt
T10473 27403-27408 Q12778 denotes FoxO1
T10474 27424-27428 P03230 denotes LMP1
T10475 27449-27452 P31751 denotes Akt
T10476 27449-27452 Q9Y243 denotes Akt
T10477 27449-27452 P31749 denotes Akt
T10478 27486-27491 Q12778 denotes FoxO1
T10479 27678-27681 P46527 denotes p27
T10480 27691-27695 P03230 denotes LMP1
T10481 27756-27759 P46527 denotes p27
T10482 27777-27781 P24941 denotes Cdk2
T10483 27860-27862 P06400 denotes Rb
T10484 27892-27896 P03230 denotes LMP1
T10485 27940-27942 P06400 denotes Rb
T10486 27987-27990 P06400 denotes pRb
T10487 27992-27996 P24941 denotes Cdk2
T10488 28002-28005 P46527 denotes p27
T10489 28032-28036 P15391 denotes CD19
T10490 28061-28065 P03230 denotes LMP1
T10491 28108-28111 P06400 denotes pRb
T10492 28152-28154 P06400 denotes Rb
T10493 28166-28170 P24941 denotes Cdk2
T10494 28266-28270 P03230 denotes LMP1
T10495 28324-28326 P06400 denotes Rb
T10496 28359-28363 P24941 denotes Cdk2
T10497 28389-28392 P46527 denotes p27
T10498 28435-28437 P06400 denotes Rb
T10499 28464-28468 P03230 denotes LMP1
T10500 28545-28550 Q12778 denotes FoxO1
T10501 28565-28568 P46527 denotes p27
T12663 28571-28575 P03230 denotes LMP1
T12664 28633-28636 P31749 denotes Akt
T12665 28633-28636 P31751 denotes Akt
T12666 28633-28636 Q9Y243 denotes Akt
T12667 28648-28653 P40763 denotes Stat3
T12668 28743-28747 P03230 denotes LMP1
T12669 28798-28802 P03230 denotes LMP1
T12670 28867-28870 P31749 denotes Akt
T12671 28867-28870 Q9Y243 denotes Akt
T12672 28867-28870 P31751 denotes Akt
T12673 28878-28883 P40763 denotes Stat3
T12674 28885-28889 P42345 denotes mTOR
T12675 29103-29107 P03230 denotes LMP1
T12676 29346-29349 P31749 denotes Akt
T12677 29346-29349 P31751 denotes Akt
T12678 29346-29349 Q9Y243 denotes Akt
T12679 29432-29435 P31749 denotes Akt
T12680 29432-29435 Q9Y243 denotes Akt
T12681 29432-29435 P31751 denotes Akt
T12682 29597-29600 P31751 denotes Akt
T12683 29597-29600 Q9Y243 denotes Akt
T12684 29597-29600 P31749 denotes Akt
T12685 29644-29648 P03230 denotes LMP1
T12686 29777-29780 P31751 denotes Akt
T12687 29777-29780 P31749 denotes Akt
T12688 29777-29780 Q9Y243 denotes Akt
T12689 29782-29787 P40763 denotes Stat3
T12690 29809-29813 P25963 denotes IκBα
T12691 29892-29895 P31749 denotes Akt
T12692 29892-29895 Q9Y243 denotes Akt
T12693 29892-29895 P31751 denotes Akt
T12694 29916-29919 P31749 denotes Akt
T12695 29916-29919 Q9Y243 denotes Akt
T12696 29916-29919 P31751 denotes Akt
T12697 29969-29974 P40763 denotes Stat3
T12698 29979-29983 P25963 denotes IκBα
T12699 30074-30077 P31749 denotes Akt
T12700 30074-30077 Q9Y243 denotes Akt
T12701 30074-30077 P31751 denotes Akt
T12702 30087-30090 Q9Y243 denotes Akt
T12703 30087-30090 P31751 denotes Akt
T12704 30087-30090 P31749 denotes Akt
T12705 31595-31599 P03230 denotes LMP1
T12706 31790-31793 P31749 denotes Akt
T12707 31790-31793 P31751 denotes Akt
T12708 31790-31793 Q9Y243 denotes Akt
T12709 31795-31800 P40763 denotes Stat3
T12710 31812-31816 P25963 denotes IκBα
T12711 31979-31983 P03230 denotes LMP1
T12712 32071-32074 Q9Y243 denotes Akt
T12713 32071-32074 P31749 denotes Akt
T12714 32071-32074 P31751 denotes Akt
T12715 32078-32083 P40763 denotes Stat3
T12716 32123-32128 P40763 denotes Stat3
T12717 32271-32276 P40763 denotes Stat3
T12718 32294-32298 P03230 denotes LMP1
T12719 32501-32504 Q9Y243 denotes Akt
T12720 32501-32504 P31751 denotes Akt
T12721 32501-32504 P31749 denotes Akt
T12722 32506-32511 P40763 denotes Stat3
T12723 32523-32527 P25963 denotes IκBα
T12724 32706-32711 P40763 denotes Stat3
T12725 32774-32777 Q9Y243 denotes Akt
T12726 32774-32777 P31751 denotes Akt
T12727 32774-32777 P31749 denotes Akt
T12728 32779-32784 P40763 denotes Stat3
T12729 32799-32803 P25963 denotes IκBα
T12730 32881-32886 P40763 denotes Stat3
T12731 32912-32916 P03230 denotes LMP1
T12732 32964-32969 P40763 denotes Stat3
T12733 33024-33027 P31749 denotes Akt
T12734 33024-33027 P31751 denotes Akt
T12735 33024-33027 Q9Y243 denotes Akt
T12736 33048-33052 P03230 denotes LMP1
T12737 33093-33096 Q15759 denotes p38
T12738 33093-33096 O15264 denotes p38
T12739 33093-33096 Q16539 denotes p38
T12740 33093-33096 P53778 denotes p38
T12741 33124-33128 P03230 denotes LMP1
T12742 33226-33229 P53778 denotes p38
T12743 33226-33229 Q16539 denotes p38
T12744 33226-33229 Q15759 denotes p38
T12745 33226-33229 O15264 denotes p38
T12746 33267-33271 Q02750 denotes MEK1
T12747 33419-33422 Q15759 denotes p38
T12748 33419-33422 Q16539 denotes p38
T12749 33419-33422 O15264 denotes p38
T12750 33419-33422 P53778 denotes p38
T12751 33491-33495 P03230 denotes LMP1
T12752 33583-33587 P03230 denotes LMP1
T12753 33770-33773 P31749 denotes Akt
T12754 33770-33773 Q9Y243 denotes Akt
T12755 33770-33773 P31751 denotes Akt
T12756 33785-33790 P40763 denotes Stat3
T12757 33913-33917 P42345 denotes mTOR
T12758 34013-34017 P42345 denotes mTOR
T12759 34037-34040 Q9Y243 denotes Akt
T12760 34037-34040 P31751 denotes Akt
T12761 34037-34040 P31749 denotes Akt
T12762 34055-34059 P03230 denotes LMP1
T16005 34182-34186 P03230 denotes LMP1
T16006 34224-34228 P03230 denotes LMP1
T16007 34362-34366 P03230 denotes LMP1
T16008 34403-34407 P03230 denotes LMP1
T16009 34548-34552 P03230 denotes LMP1
T16010 34660-34664 P03230 denotes LMP1
T16011 34758-34762 P03230 denotes LMP1
T16012 34863-34867 P03230 denotes LMP1
T16013 35010-35014 P03230 denotes LMP1
T16014 35076-35080 P25942 denotes CD40
T16015 35226-35230 P25942 denotes CD40
T16016 35244-35248 P03230 denotes LMP1
T16017 35347-35351 P03230 denotes LMP1
T16018 35556-35560 P03230 denotes LMP1
T16019 36090-36094 P03230 denotes LMP1
T16020 36164-36168 P03230 denotes LMP1
T16021 36360-36364 P25942 denotes CD40
T16022 37076-37080 P03230 denotes LMP1
T16023 37222-37226 P03230 denotes LMP1
T16024 37518-37522 P03230 denotes LMP1
T16025 37644-37648 P03230 denotes LMP1
T16026 37848-37852 P22301 denotes IL10
T16027 37881-37886 P40763 denotes Stat3
T16028 37934-37937 P31751 denotes Akt
T16029 37934-37937 P31749 denotes Akt
T16030 37934-37937 Q9Y243 denotes Akt
T16031 37949-37954 P40763 denotes Stat3
T16032 37996-38000 P22301 denotes IL10
T16033 38194-38198 P03230 denotes LMP1
T16034 38227-38231 P22301 denotes IL10
T16035 38311-38316 P40763 denotes Stat3
T16036 38385-38389 P22301 denotes IL10
T16037 38410-38415 P40763 denotes Stat3
T16038 38454-38458 P22301 denotes IL10
T16039 38490-38494 P03230 denotes LMP1
T16040 38628-38632 P03230 denotes LMP1
T16041 38660-38664 P03230 denotes LMP1
T16042 38744-38748 P25942 denotes CD40
T16043 38795-38799 Q04864 denotes cRel
T16044 38887-38891 P25942 denotes CD40
T16045 38940-38944 Q04864 denotes cRel
T16046 38993-38997 P03230 denotes LMP1
T16047 39050-39054 Q04864 denotes cRel
T16048 39143-39147 P25942 denotes CD40
T16049 39171-39175 P03230 denotes LMP1
T16050 39234-39237 P31751 denotes Akt
T16051 39234-39237 P31749 denotes Akt
T16052 39234-39237 Q9Y243 denotes Akt
T16053 39280-39284 Q04864 denotes cRel
T16054 39286-39290 P25942 denotes CD40
T16055 39347-39350 P46527 denotes p27
T16056 39392-39396 P03230 denotes LMP1
T16057 39441-39444 P46527 denotes p27
T16058 39469-39471 P06400 denotes Rb
T16059 39486-39490 P24941 denotes Cdk2
T16060 39518-39522 P03230 denotes LMP1
T16061 39556-39558 P06400 denotes Rb
T16062 39697-39700 Q9Y243 denotes Akt
T16063 39697-39700 P31749 denotes Akt
T16064 39697-39700 P31751 denotes Akt
T16065 39794-39797 P31749 denotes Akt
T16066 39794-39797 Q9Y243 denotes Akt
T16067 39794-39797 P31751 denotes Akt
T16068 39832-39836 Q9Y243 denotes pAkt
T16069 39832-39836 P31751 denotes pAkt
T16070 39832-39836 P31749 denotes pAkt
T16071 39911-39915 P49841 denotes GSK3
T16072 39911-39915 P49840 denotes GSK3
T16073 40074-40078 P03230 denotes LMP1
T16074 40123-40127 P03230 denotes LMP1
T16075 40249-40253 P42345 denotes mTOR
T16076 40308-40311 Q9Y243 denotes Akt
T16077 40308-40311 P31751 denotes Akt
T16078 40308-40311 P31749 denotes Akt
T16079 40486-40491 Q12778 denotes FoxO1
T16080 40545-40549 P41182 denotes bcl6
T16081 40652-40656 P25942 denotes CD40
T16082 40750-40754 P25942 denotes CD40
T16083 40777-40781 P03230 denotes LMP1
T16084 40861-40865 P03230 denotes LMP1
T16085 40919-40923 P41182 denotes bcl6
T16086 40985-40989 P03230 denotes LMP1
T16087 40994-40998 P41182 denotes bcl6
T16088 41068-41072 P03230 denotes LMP1
T16089 41155-41158 P31749 denotes Akt
T16090 41155-41158 P31751 denotes Akt
T16091 41155-41158 Q9Y243 denotes Akt
T16092 41216-41220 P03230 denotes LMP1
T16093 41229-41233 P41182 denotes bcl6
T16094 41354-41357 P46527 denotes p27
T16095 41435-41440 Q12778 denotes FoxO1
T16096 41496-41499 P46527 denotes p27
T16097 41570-41574 P03230 denotes LMP1
T16098 41594-41599 Q12778 denotes FoxO1
T16099 41683-41687 P03230 denotes LMP1
T16100 41856-41861 P40763 denotes Stat3
T16101 41883-41886 P46527 denotes p27
T16102 41902-41905 P31749 denotes Akt
T16103 41902-41905 Q9Y243 denotes Akt
T16104 41902-41905 P31751 denotes Akt
T16105 42026-42029 P31749 denotes Akt
T16106 42026-42029 P31751 denotes Akt
T16107 42026-42029 Q9Y243 denotes Akt
T16108 42041-42046 P40763 denotes Stat3
T16109 42153-42157 P03230 denotes LMP1
T16110 42301-42305 P03230 denotes LMP1
T16111 42468-42472 P03230 denotes LMP1
T18795 43727-43731 P15391 denotes CD19
T18796 44082-44086 P15391 denotes CD19
T18797 44186-44189 P05112 denotes IL4
T18798 44232-44236 P22301 denotes IL10
T18799 44274-44278 P22301 denotes IL10
T19311 44736-44739 P05112 denotes IL4
T19312 44823-44826 P05112 denotes IL4
T19313 45151-45154 P05112 denotes IL4
T19314 45176-45179 P05112 denotes IL4
T19817 46066-46068 P0A7Z4 denotes pH
T19818 46086-46090 P03230 denotes LMP1
T19819 46113-46119 P40763 denotes pStat3
T19820 46135-46139 P03230 denotes LMP1
T19821 46284-46288 P03230 denotes LMP1
T19822 46674-46679 P40763 denotes Stat3
T19823 46709-46715 P40763 denotes pStat3
T22025 8483-8487 P03230 denotes LMP1
T22026 8543-8547 P03230 denotes LMP1
T22027 8611-8615 P15391 denotes CD19
T22028 8697-8701 P03230 denotes LMP1
T22029 8789-8793 P03230 denotes LMP1
T22319 10554-10558 P03230 denotes LMP1
T22320 10673-10677 P03230 denotes LMP1
T22321 10718-10722 P15391 denotes CD19
T22322 10736-10739 P06127 denotes CD5
T22323 10855-10859 P03230 denotes LMP1
T22324 10924-10928 P03230 denotes LMP1
T22325 11117-11121 P03230 denotes LMP1
T22326 11155-11159 P15391 denotes CD19
T22327 11160-11163 P06127 denotes CD5
T22328 11190-11194 P15391 denotes CD19
T22329 11195-11198 P06127 denotes CD5
T22330 11332-11336 P03230 denotes LMP1
T22331 11436-11440 P15391 denotes CD19
T22332 11464-11468 P03230 denotes LMP1
T22840 14367-14371 P03230 denotes LMP1
T22841 14465-14469 P03230 denotes LMP1
T22842 14568-14571 P05112 denotes IL4
T22843 14769-14773 P03230 denotes LMP1
T22844 14813-14817 P03230 denotes LMP1
T22845 14861-14865 P15391 denotes CD19
T22846 14897-14901 P03230 denotes LMP1
T22847 15006-15009 P05112 denotes IL4
T22848 15079-15083 P03230 denotes LMP1
T22849 15135-15138 P05112 denotes IL4
T22850 15193-15197 P03230 denotes LMP1
T23345 17955-17959 P03230 denotes LMP1
T23346 18011-18014 P05112 denotes IL4
T23347 18015-18020 P42226 denotes Stat6
T23348 18073-18076 P05112 denotes IL4
T23349 18105-18109 P15391 denotes CD19
T23350 18124-18128 P03230 denotes LMP1
T23351 18157-18160 Q9BYC8 denotes L32
T23352 18157-18160 P62910 denotes L32
T23353 18165-18170 P04406 denotes GAPDH
T23354 18315-18319 P03230 denotes LMP1
T23355 18350-18356 P42226 denotes pStat6
T23356 18382-18386 P15391 denotes CD19
T23357 18465-18468 P05112 denotes IL4
T23358 18636-18640 P03230 denotes LMP1
T23359 18681-18684 P05112 denotes IL4
T23360 18713-18716 P05112 denotes IL4
T23361 18807-18811 P03230 denotes LMP1
T23940 22890-22894 P03230 denotes LMP1
T23941 22907-22911 P22301 denotes IL10
T23942 22952-22957 P40763 denotes Stat3
T23943 22962-22970 Q04864 denotes Relative
T23944 22985-22989 P22301 denotes IL10
T23945 22991-22995 P40933 denotes IL15
T23946 23021-23025 P03230 denotes LMP1
T23947 23046-23050 P15391 denotes CD19
T23948 23278-23281 P62910 denotes L32
T23949 23278-23281 Q9BYC8 denotes L32
T23950 23296-23299 Q9BYC8 denotes L32
T23951 23296-23299 P62910 denotes L32
T23952 23401-23407 P40763 denotes pStat3
T23953 23429-23433 P15391 denotes CD19
T23954 23448-23452 P03230 denotes LMP1
T23955 23539-23543 P22301 denotes IL10
T23956 23572-23576 P22301 denotes IL10
T23957 23657-23661 P03230 denotes LMP1
T23958 23742-23747 P40763 denotes Stat3
T23959 23842-23848 P40763 denotes pStat3
T23960 23874-23878 P03230 denotes LMP1
T24499 25723-25727 P03230 denotes LMP1
T24500 25738-25741 P31751 denotes Akt
T24501 25738-25741 Q9Y243 denotes Akt
T24502 25738-25741 P31749 denotes Akt
T24503 25772-25774 P06400 denotes Rb
T24504 25845-25849 P15391 denotes CD19
T24505 25879-25883 P03230 denotes LMP1
T24506 25904-25907 P31751 denotes Akt
T24507 25904-25907 P31749 denotes Akt
T24508 25904-25907 Q9Y243 denotes Akt
T24509 25945-25949 Q9Y243 denotes pAkt
T24510 25945-25949 P31751 denotes pAkt
T24511 25945-25949 P31749 denotes pAkt
T24512 26026-26030 P42345 denotes mTOR
T24513 26052-26057 Q12778 denotes FoxO1
T24514 26112-26116 P49841 denotes GSK3
T24515 26112-26116 P49840 denotes GSK3
T24516 26252-26254 P06400 denotes Rb
T24517 26286-26289 P06400 denotes pRb
T24518 26311-26315 P24941 denotes Cdk2
T24519 26338-26341 P46527 denotes p27
T24955 30201-30204 Q9Y243 denotes Akt
T24956 30201-30204 P31751 denotes Akt
T24957 30201-30204 P31749 denotes Akt
T24958 30216-30221 P40763 denotes Stat3
T24959 30347-30351 P03230 denotes LMP1
T24960 30387-30391 P03230 denotes LMP1
T24961 30486-30490 P42345 denotes mTOR
T24962 30504-30507 P31749 denotes Akt
T24963 30504-30507 P31751 denotes Akt
T24964 30504-30507 Q9Y243 denotes Akt
T24965 30523-30527 Q02750 denotes MEK1
T24966 30539-30542 P53778 denotes p38
T24967 30539-30542 Q15759 denotes p38
T24968 30539-30542 Q16539 denotes p38
T24969 30539-30542 O15264 denotes p38
T24970 30558-30563 P40763 denotes Stat3
T24971 30739-30743 P03230 denotes LMP1
T24972 30796-30800 P03230 denotes LMP1
T24973 30859-30863 P03230 denotes LMP1
T25340 30934-30937 Q9Y243 denotes Akt
T25341 30934-30937 P31751 denotes Akt
T25342 30934-30937 P31749 denotes Akt
T25343 30949-30954 P40763 denotes Stat3
T25344 31068-31072 P03230 denotes LMP1
T25345 31098-31101 Q9Y243 denotes Akt
T25346 31098-31101 P31749 denotes Akt
T25347 31098-31101 P31751 denotes Akt
T25348 31113-31118 P40763 denotes Stat3
T25349 31157-31160 Q9Y243 denotes Akt
T25350 31157-31160 P31751 denotes Akt
T25351 31157-31160 P31749 denotes Akt
T25352 31228-31233 P40763 denotes Stat3
T25353 31365-31370 P40763 denotes Stat3
T233 4-29 P03230 denotes Latent Membrane Protein 1
T234 40-43 Q9Y243 denotes Akt
T235 40-43 P31749 denotes Akt
T236 40-43 P31751 denotes Akt
T237 55-60 P40763 denotes Stat3
T238 141-166 P03230 denotes Latent membrane protein 1
T239 168-172 P03230 denotes LMP1
T240 248-252 P03230 denotes LMP1
T241 514-517 Q9Y243 denotes Akt
T242 514-517 P31751 denotes Akt
T243 514-517 P31749 denotes Akt
T244 529-534 P40763 denotes Stat3
T245 567-571 P03230 denotes LMP1
T246 658-661 P05112 denotes IL4
T247 662-667 P42226 denotes Stat6
T248 744-749 P40763 denotes Stat3
T21451 50409-50413 P15391 denotes CD19
T21452 50459-50463 P03230 denotes LMP1
T21453 50508-50510 P06400 denotes Rb
T21454 50531-50535 P24941 denotes Cdk2
T21455 50618-50621 P06127 denotes CD5
T21456 50678-50682 P03230 denotes LMP1
T21457 50757-50761 Q9Y243 denotes pAkt
T21458 50757-50761 P31749 denotes pAkt
T21459 50757-50761 P31751 denotes pAkt
T21460 50802-50808 P40763 denotes pStat3
T21461 50824-50830 P42226 denotes pStat6
T21462 50868-50873 P42226 denotes Stat6
T21463 50880-50883 Q9Y243 denotes Akt
T21464 50880-50883 P31749 denotes Akt
T21465 50880-50883 P31751 denotes Akt
T21466 50890-50895 Q12778 denotes FoxO1
T21467 50906-50909 P46527 denotes p27
T21468 50958-50963 P40763 denotes Stat3
T21469 50978-50982 P25963 denotes IκBα
T21470 51005-51012 P60709 denotes β actin
T21471 51083-51087 P49840 denotes GSK3
T21472 51083-51087 P49841 denotes GSK3
T21473 51142-51145 P06400 denotes pRb
T4669 9923-9926 P06127 denotes CD5
T4670 9952-9956 P03230 denotes LMP1
T4671 10323-10327 P03230 denotes LMP1
T4672 10419-10423 P15391 denotes CD19
T4673 10424-10427 P06127 denotes CD5
T4674 10459-10463 P15391 denotes CD19
T4675 10464-10467 P06127 denotes CD5
T4676 10487-10491 P03230 denotes LMP1
T4677 11723-11727 P03230 denotes LMP1
T4678 11889-11893 P03230 denotes LMP1
T4679 12526-12530 P03230 denotes LMP1
T4680 12931-12935 P03230 denotes LMP1
T18429 42576-42580 P03230 denotes LMP1
T18430 42729-42733 P03230 denotes LMP1
T20533 47595-47599 P15391 denotes CD19
T21194 49239-49241 P0A7Z4 denotes pH
T25520 16951-16955 P03230 denotes LMP1

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T14303 40901-40915 Negative_regulation denotes downregulation
T14304 40919-40923 Protein denotes bcl6
T14305 40971-40981 Gene_expression denotes expression
T14306 40985-40989 Protein denotes LMP1
T14307 40994-40998 Protein denotes bcl6
T14308 41068-41072 Protein denotes LMP1
T14309 41141-41151 Positive_regulation denotes activation
T14310 41155-41158 Protein denotes Akt
T14311 41167-41171 Negative_regulation denotes lack
T14312 41175-41180 Protein denotes Fox01
T14313 41216-41220 Protein denotes LMP1
T14314 41221-41228 Regulation denotes affects
T14315 41229-41233 Protein denotes bcl6
T14316 41354-41357 Protein denotes p27
T14317 41362-41370 Protein denotes CyclinD2
T14318 41427-41431 Negative_regulation denotes loss
T14319 41435-41440 Protein denotes FoxO1
T14320 41441-41451 Gene_expression denotes expression
T14321 41470-41480 Positive_regulation denotes correlated
T14322 41488-41492 Negative_regulation denotes loss
T14323 41496-41499 Protein denotes p27
T14324 41520-41528 Protein denotes CyclinD2
T14325 41570-41574 Protein denotes LMP1
T14326 41583-41590 Localization denotes release
T14327 41594-41599 Protein denotes FoxO1
T14328 41683-41687 Protein denotes LMP1
T14329 41856-41861 Protein denotes Stat3
T14330 41873-41882 Negative_regulation denotes decreased
T14331 41883-41886 Protein denotes p27
T14332 41902-41905 Protein denotes Akt
T14333 42026-42029 Protein denotes Akt
T14334 42041-42046 Protein denotes Stat3
T14335 42153-42157 Protein denotes LMP1
T14336 42301-42305 Protein denotes LMP1
T14337 42468-42472 Protein denotes LMP1
T22 4-29 Protein denotes Latent Membrane Protein 1
T23 30-39 Positive_regulation denotes Activates
T24 40-43 Protein denotes Akt
T25 55-60 Protein denotes Stat3
T26 141-166 Protein denotes Latent membrane protein 1 true
T27 168-172 Protein denotes LMP1 true
T28 248-252 Protein denotes LMP1 true
T29 514-517 Protein denotes Akt
T30 529-534 Protein denotes Stat3
T31 567-571 Protein denotes LMP1
T32 658-661 Protein denotes IL4
T33 662-667 Protein denotes Stat6
T34 734-743 Positive_regulation denotes activated
T35 744-749 Protein denotes Stat3
T36 909-912 Protein denotes Akt
T37 924-929 Protein denotes Stat3
T608 2641-2666 Protein denotes Latent membrane protein 1
T609 2668-2672 Protein denotes LMP1
T610 2792-2801 Gene_expression denotes expressed
T611 2879-2883 Protein denotes LMP1
T612 2891-2895 Protein denotes CD40
T613 2916-2920 Protein denotes LMP1
T614 2925-2929 Protein denotes CD40
T615 2997-3001 Protein denotes CD40
T616 3002-3011 Binding denotes interacts
T617 3017-3028 Protein denotes CD40 ligand
T618 3029-3038 Gene_expression denotes expressed
T619 3109-3113 Protein denotes LMP1
T620 3188-3192 Protein denotes LMP1
T621 3197-3201 Protein denotes CD40
T622 3202-3210 Binding denotes interact
T623 3225-3246 Protein denotes tumor necrosis factor
T624 3314-3319 Protein denotes c-Jun
T625 3542-3546 Protein denotes LMP1
T626 3599-3602 Protein denotes Akt
T627 3654-3658 Protein denotes LMP1
T628 3760-3764 Protein denotes CD40
T629 3765-3773 Binding denotes ligation
T630 3794-3797 Protein denotes IL4
T631 3818-3822 Protein denotes CD40
T632 3896-3905 Negative_regulation denotes deficient
T633 3910-3914 Protein denotes CD40
T634 3918-3923 Protein denotes CD40L
T635 4035-4054 Entity denotes cytoplasmic regions
T636 4058-4062 Protein denotes CD40
T637 4068-4072 Binding denotes bind true true
T638 4073-4078 Protein denotes TRAF6 true true
T639 4083-4089 Protein denotes TRAFs2
T640 4090-4091 Protein denotes 3
T641 4092-4093 Protein denotes 5
T642 4287-4291 Protein denotes LMP1
T643 4303-4307 Protein denotes CD40
T644 4308-4317 Negative_regulation denotes deficient
T645 4392-4396 Protein denotes LMP1
T646 4397-4405 Binding denotes recruits
T647 4430-4437 Protein denotes TRAFs 1
T648 4438-4439 Protein denotes 2
T649 4440-4441 Protein denotes 3
T650 4442-4443 Protein denotes 5
T651 4448-4453 Protein denotes TRAF6
T652 4467-4498 Entity denotes C-terminal activation regions 1
T653 4503-4512 Entity denotes 2 domains
T654 4537-4541 Protein denotes LMP1
T655 4700-4704 Protein denotes LMP1
T656 4736-4745 Gene_expression denotes expressed
T657 4746-4763 Positive_regulation denotes under the control
T658 4821-4825 Protein denotes LMP1
T659 4851-4858 Gene_expression denotes express
T660 4859-4863 Protein denotes LMP1
T661 5023-5027 Protein denotes LMP1
T662 5071-5075 Protein denotes LMP1
T663 5120-5129 Positive_regulation denotes activated
T664 5130-5133 Protein denotes Akt
T665 5169-5179 Positive_regulation denotes activation
T666 5206-5210 Protein denotes cRel
T667 5236-5240 Protein denotes LMP1
T668 5684-5688 Protein denotes LMP1
T669 5763-5772 Positive_regulation denotes increased
T670 5792-5795 Protein denotes IL4
T671 5815-5819 Protein denotes LMP1
T672 5820-5828 Gene_expression denotes positive
T673 5878-5881 Protein denotes IL4
T674 5953-5960 Negative_regulation denotes absence
T675 5964-5973 Positive_regulation denotes activated
T676 5974-5979 Protein denotes Stat6
T677 5985-5988 Protein denotes IL4
T678 6051-6061 Positive_regulation denotes activation
T679 6065-6070 Protein denotes Stat3
T680 6095-6097 Protein denotes Rb
T681 6141-6144 Protein denotes Akt
T682 6156-6161 Protein denotes Stat3
T683 6217-6221 Protein denotes LMP1
T684 6497-6501 Protein denotes LMP1
T685 6585-6588 Protein denotes Akt
T686 6600-6605 Protein denotes Stat3
T3115 6699-6703 Protein denotes LMP1
T3116 6704-6714 Gene_expression denotes Expression
T3117 6759-6763 Protein denotes LMP1
T3118 6764-6774 Gene_expression denotes expression
T3119 6824-6831 Regulation denotes control
T3120 6937-6941 Protein denotes LMP1
T3121 6942-6952 Gene_expression denotes expression
T3122 7068-7072 Protein denotes LMP1
T3123 7073-7083 Gene_expression denotes expression
T3124 7193-7197 Protein denotes CD19
T3125 7286-7290 Protein denotes LMP1
T3126 7309-7313 Protein denotes LMP1 true
T3127 7368-7372 Protein denotes LMP1
T3128 7373-7383 Gene_expression denotes expression
T3129 7529-7533 Protein denotes LMP1
T3130 7593-7603 Gene_expression denotes expression true
T3131 7607-7611 Protein denotes LMP1
T3132 7739-7743 Protein denotes LMP1
T3133 7867-7871 Protein denotes LMP1
T3134 7872-7882 Gene_expression denotes expression
T3135 7913-7917 Protein denotes LMP1
T3136 7990-7994 Protein denotes LMP1
T3137 8026-8030 Protein denotes LMP1
T3138 8031-8041 Gene_expression denotes expression
T3139 8093-8100 Positive_regulation denotes intense
T3140 8101-8105 Protein denotes LMP1
T3141 8143-8152 Positive_regulation denotes increased
T3142 8153-8157 Protein denotes LMP1
T3143 8224-8232 Positive_regulation denotes increase
T3144 8236-8240 Protein denotes LMP1
T3145 8241-8251 Gene_expression denotes expression
T3146 8281-8291 Gene_expression denotes expressing
T3147 8307-8311 Protein denotes LMP1
T3148 8338-8342 Positive_regulation denotes high
T3149 8343-8347 Protein denotes LMP1
T3150 8348-8358 Gene_expression denotes expression
T3151 8442-8451 Positive_regulation denotes increased
T3152 8462-8466 Protein denotes LMP1
T4044 9020-9024 Protein denotes LMP1
T4045 9099-9103 Protein denotes LMP1
T4046 9198-9202 Protein denotes LMP1
T4047 9203-9213 Gene_expression denotes expression
T4048 9455-9459 Protein denotes LMP1
T4049 9493-9497 Protein denotes LMP1
T4050 9621-9625 Protein denotes LMP1
T4051 9786-9789 Protein denotes CD5
T4052 9802-9805 Protein denotes CD5
T4053 9923-9926 Protein denotes CD5
T4054 9952-9956 Protein denotes LMP1
T4055 9991-10007 Protein denotes IgMhighIgDlowCD5
T4056 10323-10327 Protein denotes LMP1
T4057 10419-10423 Protein denotes CD19
T4058 10424-10427 Protein denotes CD5
T4059 10459-10463 Protein denotes CD19
T4060 10464-10467 Protein denotes CD5
T4061 10487-10491 Protein denotes LMP1
T4062 11723-11727 Protein denotes LMP1
T4063 11889-11893 Protein denotes LMP1
T4064 12526-12530 Protein denotes LMP1
T4065 12917-12927 Gene_expression denotes expression
T4066 12931-12935 Protein denotes LMP1
T5432 13052-13056 Protein denotes LMP1
T5433 13159-13163 Protein denotes CD40
T5434 13164-13172 Binding denotes ligation
T5435 13198-13201 Protein denotes IL4
T5436 13231-13235 Protein denotes LMP1
T5437 13332-13339 Negative_regulation denotes absence
T5438 13343-13346 Protein denotes IL4
T5439 13620-13623 Protein denotes IL4
T5440 13624-13627 Positive_regulation denotes due
T5441 13633-13637 Negative_regulation denotes lack
T5442 13641-13645 Protein denotes CD40 true
T5443 13646-13654 Binding denotes ligation
T5444 13681-13685 Protein denotes LMP1
T5445 13735-13742 Negative_regulation denotes absence
T5446 13746-13749 Protein denotes IL4
T5447 13769-13777 Positive_regulation denotes enhanced
T5448 13795-13798 Protein denotes IL4
T5449 13814-13818 Protein denotes LMP1
T5450 13889-13896 Negative_regulation denotes absence
T5451 13900-13903 Protein denotes IL4
T5452 13921-13925 Protein denotes LMP1
T5453 15289-15293 Protein denotes CD19
T5454 15345-15349 Protein denotes LMP1
T5455 15414-15418 Protein denotes LMP1
T5456 15493-15497 Protein denotes LMP1
T5457 15569-15578 Positive_regulation denotes increased
T5458 15582-15585 Protein denotes IL4
T5459 15651-15654 Protein denotes IL4
T5460 15727-15731 Protein denotes LMP1
T5461 15777-15780 Protein denotes IL4
T5462 15876-15879 Protein denotes IL4
T5463 15942-15946 Protein denotes LMP1
T5464 15983-15993 Gene_expression denotes expression
T5465 15997-16001 Protein denotes LMP1
T5466 16096-16100 Protein denotes LMP1
T5467 16101-16111 Gene_expression denotes expression
T5468 16311-16315 Protein denotes LMP1
T5469 16443-16447 Protein denotes LMP1
T5470 16448-16456 Negative_regulation denotes negative
T5471 16551-16558 Gene_expression denotes express
T5472 16579-16583 Protein denotes LMP1
T5473 16591-16595 Protein denotes LMP1
T5474 16618-16622 Protein denotes LMP1
T5475 16637-16641 Protein denotes LMP1
T5476 16681-16685 Protein denotes LMP1
T5477 16780-16788 Positive_regulation denotes enhanced
T5478 16794-16797 Protein denotes IL4
T5479 16823-16826 Protein denotes IL4
T6321 9621-9625 Protein denotes LMP1
T6322 17038-17041 Protein denotes IL4 true
T6323 17046-17051 Protein denotes Stat6
T6324 17085-17088 Protein denotes IL4 true
T6325 17106-17109 Positive_regulation denotes due
T6326 17124-17127 Protein denotes IL4
T6327 17128-17138 Gene_expression denotes expression
T6328 17140-17143 Protein denotes IL4
T6329 17144-17157 Transcription denotes transcription
T6330 17207-17210 Protein denotes IL4
T6331 17211-17224 Transcription denotes transcription
T6332 17328-17331 Protein denotes IL4
T6333 17332-17345 Transcription denotes transcription
T6334 17368-17372 Protein denotes CD19
T6335 17443-17447 Protein denotes LMP1
T6336 17504-17509 Protein denotes GAPDH
T6337 17514-17517 Protein denotes L32
T6338 17567-17576 Positive_regulation denotes Activated
T6339 17577-17582 Protein denotes Stat6
T6340 17584-17590 Protein denotes pStat6
T6341 17609-17621 Protein denotes IL4 receptor
T6342 17665-17669 Protein denotes LMP1
T6343 17773-17777 Protein denotes LMP1
T6344 17884-17887 Protein denotes IL4
T6345 17888-17895 Positive_regulation denotes induced
T6346 17896-17901 Protein denotes Stat6
T6347 17902-17917 Phosphorylation denotes phosphorylation
T6348 19044-19047 Protein denotes IL4
T6349 19277-19284 Positive_regulation denotes induced
T6350 19288-19291 Protein denotes IL4
T6351 19357-19360 Protein denotes IL4
T6352 19419-19422 Protein denotes IL4
T6353 19458-19462 Protein denotes LMP1
T6354 19532-19536 Protein denotes LMP1
T6355 19585-19588 Protein denotes IL4
T6356 19619-19624 Protein denotes Stat6
T7312 19637-19641 Protein denotes LMP1
T7313 19642-19653 Positive_regulation denotes Upregulates
T7314 19654-19658 Protein denotes IL10 true
T7315 19678-19687 Positive_regulation denotes Activates true
T7316 19688-19693 Protein denotes Stat3 true
T7317 19850-19854 Protein denotes CD19 true
T7318 19906-19909 Protein denotes IL4 true
T7319 19911-19914 Protein denotes IL5 true
T7320 19916-19920 Protein denotes IL10 true
T7321 19922-19926 Protein denotes IL13 true
T7322 19928-19932 Protein denotes IL15 true
T7323 19934-19937 Protein denotes IL9
T7324 19939-19942 Protein denotes IL2
T7325 19944-19947 Protein denotes IL6
T7326 19953-19957 Protein denotes IFNγ
T7327 20065-20068 Protein denotes L32
T7328 20158-20161 Protein denotes L32
T7329 20222-20235 Transcription denotes Transcription
T7330 20239-20243 Protein denotes IL10
T7331 20245-20249 Protein denotes IL15
T7332 20255-20259 Protein denotes IFNγ
T7333 20290-20294 Protein denotes LMP1 true
T7334 20442-20452 Regulation denotes difference
T7335 20460-20470 Gene_expression denotes expression true
T7336 20474-20478 Protein denotes IL15
T7337 20483-20487 Protein denotes IFNγ
T7338 20496-20500 Protein denotes LMP1
T7339 20528-20542 Protein denotes lymphoma cells
T7340 20560-20572 Positive_regulation denotes upregulation
T7341 20576-20580 Protein denotes IL15
T7342 20585-20589 Protein denotes IFNγ
T7343 20593-20600 Positive_regulation denotes induced
T7344 20604-20608 Protein denotes LMP1
T7345 20609-20619 Gene_expression denotes expression true
T7346 20710-20714 Protein denotes IL10
T7347 20803-20807 Protein denotes LMP1
T7348 20846-20850 Protein denotes LMP1
T7349 20887-20897 Gene_expression denotes Production true true
T7350 20901-20905 Protein denotes IL15 true
T7351 20910-20914 Protein denotes IFNγ
T7352 21112-21124 Positive_regulation denotes upregulation
T7353 21128-21132 Protein denotes IL10
T7354 21153-21160 Regulation denotes effects true
T7355 21164-21168 Protein denotes IL10
T7356 21169-21181 Positive_regulation denotes upregulation true
T7357 21287-21291 Protein denotes LMP1
T7358 21333-21337 Protein denotes LMP1
T7359 21382-21391 Positive_regulation denotes increased
T7360 21402-21416 Phosphorylation denotes phosphorylated
T7361 21437-21446 Positive_regulation denotes activated true
T7362 21447-21452 Protein denotes Stat3
T7363 21456-21462 Binding denotes target
T7364 21470-21474 Protein denotes IL10
T7365 21588-21592 Protein denotes IL10
T7366 21593-21602 Positive_regulation denotes induction true
T7367 21621-21626 Protein denotes Stat3
T7368 21627-21637 Positive_regulation denotes activation
T7369 21662-21672 Positive_regulation denotes activation
T7370 21676-21681 Protein denotes Stat3
T7371 21696-21703 Positive_regulation denotes induced
T7372 21707-21711 Protein denotes IL10
T7373 21720-21725 Protein denotes Stat3
T7374 21726-21736 Positive_regulation denotes activation
T7375 21819-21823 Protein denotes LMP1
T7376 21824-21834 Gene_expression denotes expression
T7377 21853-21857 Protein denotes IL10
T7378 21858-21867 Positive_regulation denotes induction
T7379 21913-21922 Positive_regulation denotes induction
T7380 21926-21930 Protein denotes IL10
T7381 22014-22022 Regulation denotes affected
T7382 22026-22030 Protein denotes LMP1
T7383 22059-22063 Protein denotes IL10
T7384 22185-22195 Positive_regulation denotes activation
T7385 22199-22204 Protein denotes Stat3
T7386 22282-22286 Protein denotes IL10
T7387 22312-22318 Protein denotes pStat3
T7388 22335-22344 Positive_regulation denotes activated
T7389 22391-22395 Protein denotes LMP1
T7390 22452-22456 Protein denotes IL10
T7391 22457-22465 Positive_regulation denotes enhanced
T7392 22466-22472 Protein denotes pStat3
T7393 22473-22483 Positive_regulation denotes activation
T7394 22560-22564 Protein denotes IL10
T7395 22650-22655 Protein denotes Stat3
T7396 22656-22666 Positive_regulation denotes activation
T7397 22686-22694 Positive_regulation denotes enhanced
T7398 22698-22702 Protein denotes IL10
T7399 22703-22712 Positive_regulation denotes induction
T7400 22750-22754 Protein denotes IL10
T7401 22799-22803 Protein denotes IL10
T7402 22814-22818 Protein denotes IL10
T7403 23916-23923 Entity denotes Nuclear
T7404 23924-23937 Localization denotes translocation
T7405 23941-23947 Protein denotes pStat3
T7406 23984-23991 Entity denotes nuclear
T7407 23992-23998 Protein denotes pStat3
T7408 24007-24015 Localization denotes detected
T7409 24096-24103 Entity denotes nuclear
T7410 24104-24110 Protein denotes pStat3
T7411 24115-24125 Localization denotes detectable
T7412 24129-24133 Protein denotes LMP1
T7413 24213-24217 Protein denotes LMP1
T7414 24269-24279 Positive_regulation denotes activation
T7415 24283-24289 Protein denotes pStat3
T7416 24303-24310 Entity denotes nuclear
T7417 24311-24316 Protein denotes Stat3
T7418 24331-24336 Protein denotes Stat3
T7419 24362-24366 Protein denotes LMP1
T9551 24399-24403 Protein denotes LMP1
T9552 24414-24417 Protein denotes Akt
T9553 24448-24450 Protein denotes Rb
T9554 24470-24474 Protein denotes LMP1
T9555 24521-24531 Positive_regulation denotes activation true
T9556 24544-24547 Protein denotes Akt
T9557 24567-24576 Positive_regulation denotes activated
T9558 24577-24581 Protein denotes pAkt true
T9559 24693-24696 Protein denotes Akt
T9560 24710-24719 Positive_regulation denotes activated true
T9561 24723-24727 Protein denotes LMP1
T9562 24745-24749 Protein denotes pAkt
T9563 24820-24824 Protein denotes CD19
T9564 24849-24853 Protein denotes LMP1 true
T9565 24877-24886 Positive_regulation denotes increased
T9566 24897-24901 Protein denotes pAkt
T9567 24978-24982 Protein denotes LMP1 true
T9568 24983-24991 Gene_expression denotes positive
T9569 25037-25045 Positive_regulation denotes increase true
T9570 25046-25050 Protein denotes pAkt true
T9571 25063-25066 Protein denotes Akt
T9572 25074-25100 Protein denotes glycogen synthase kinase 3
T9573 25102-25106 Protein denotes GSK3
T9574 25111-25122 Negative_regulation denotes inactivated
T9575 25126-25141 Phosphorylation denotes phosphorylation
T9576 25152-25161 Positive_regulation denotes increased true
T9577 25162-25176 Phosphorylation denotes phosphorylated
T9578 25177-25181 Protein denotes GSK3 true true
T9579 25316-25320 Protein denotes GSK3
T9580 25330-25336 Binding denotes target
T9581 25340-25349 Positive_regulation denotes activated
T9582 25350-25353 Protein denotes Akt
T9583 25361-25365 Protein denotes LMP1
T9584 25420-25430 Positive_regulation denotes activation
T9585 25434-25437 Protein denotes Akt
T9586 25446-25461 Phosphorylation denotes phosphorylation
T9587 25465-25469 Protein denotes GSK3
T9588 25567-25576 Positive_regulation denotes activated
T9589 25577-25580 Protein denotes Akt
T9590 25605-25619 Phosphorylation denotes phosphorylated
T9591 25620-25624 Protein denotes GSK3
T9592 25693-25703 Regulation denotes regulation
T9593 25707-25711 Protein denotes GSK3
T9594 26410-26413 Protein denotes Akt
T9595 26414-26421 Binding denotes targets
T9596 26447-26453 Protein denotes p-mTOR
T9597 26469-26478 Positive_regulation denotes Activated
T9598 26479-26485 Protein denotes p-mTOR
T9599 26494-26503 Positive_regulation denotes increased
T9600 26507-26511 Protein denotes LMP1
T9601 26590-26598 Regulation denotes affected
T9602 26602-26606 Protein denotes LMP1
T9603 26607-26614 Positive_regulation denotes induced
T9604 26615-26618 Protein denotes Akt
T9605 26619-26629 Positive_regulation denotes activation
T9606 26691-26694 Protein denotes Akt
T9607 26712-26725 Phosphorylation denotes phosphorylate
T9608 26962-26967 Protein denotes FoxO1
T9609 26998-27003 Protein denotes FoxO1
T9610 27008-27019 Protein_catabolism denotes degradation
T9611 27028-27039 Protein_catabolism denotes degradation
T9612 27043-27048 Protein denotes FoxO1
T9613 27084-27089 Protein denotes FoxO1
T9614 27139-27144 Protein denotes FoxO1
T9615 27165-27174 Negative_regulation denotes decreased
T9616 27192-27196 Protein denotes LMP1
T9617 27308-27314 Binding denotes target
T9618 27318-27321 Protein denotes Akt
T9619 27373-27376 Protein denotes Akt
T9620 27377-27387 Positive_regulation denotes activation
T9621 27396-27402 Positive_regulation denotes induce
T9622 27403-27408 Protein denotes FoxO1
T9623 27409-27420 Protein_catabolism denotes degradation
T9624 27424-27428 Protein denotes LMP1
T9625 27449-27452 Protein denotes Akt
T9626 27473-27482 Regulation denotes regulator
T9627 27486-27491 Protein denotes FoxO1
T9628 27635-27641 Positive_regulation denotes induce
T9629 27646-27656 Gene_expression denotes expression
T9630 27668-27677 Negative_regulation denotes inhibitor
T9631 27678-27681 Protein denotes p27
T9632 27691-27695 Protein denotes LMP1
T9633 27732-27741 Negative_regulation denotes decreased
T9634 27742-27752 Gene_expression denotes expression
T9635 27756-27759 Protein denotes p27
T9636 27761-27773 Positive_regulation denotes upregulation
T9637 27777-27781 Protein denotes Cdk2
T9638 27860-27862 Protein denotes Rb
T9639 27892-27896 Protein denotes LMP1
T9640 27940-27942 Protein denotes Rb
T9641 27987-27990 Protein denotes pRb
T9642 27992-27996 Protein denotes Cdk2
T9643 28002-28005 Protein denotes p27
T9644 28032-28036 Protein denotes CD19
T9645 28061-28065 Protein denotes LMP1
T9646 28089-28097 Positive_regulation denotes enhanced
T9647 28108-28111 Protein denotes pRb
T9648 28152-28154 Protein denotes Rb
T9649 28166-28170 Protein denotes Cdk2
T9650 28266-28270 Protein denotes LMP1
T9651 28297-28300 Positive_regulation denotes led
T9652 28304-28313 Positive_regulation denotes increased
T9653 28324-28326 Protein denotes Rb
T9654 28344-28348 Positive_regulation denotes high
T9655 28359-28363 Protein denotes Cdk2
T9656 28369-28378 Negative_regulation denotes decreased
T9657 28389-28392 Protein denotes p27
T9658 28435-28437 Protein denotes Rb
T9659 28464-28468 Protein denotes LMP1
T9660 28537-28541 Negative_regulation denotes loss
T9661 28545-28550 Protein denotes FoxO1
T9662 28555-28564 Negative_regulation denotes decreased
T9663 28565-28568 Protein denotes p27
T11653 28571-28575 Protein denotes LMP1
T11654 28619-28629 Positive_regulation denotes Activation
T11655 28633-28636 Protein denotes Akt
T11656 28648-28653 Protein denotes Stat3
T11657 28743-28747 Protein denotes LMP1
T11658 28798-28802 Protein denotes LMP1
T11659 28852-28862 Negative_regulation denotes inhibitors
T11660 28867-28870 Protein denotes Akt
T11661 28878-28883 Protein denotes Stat3
T11662 28885-28889 Protein denotes mTOR
T11663 29103-29107 Protein denotes LMP1
T11664 29147-29154 Negative_regulation denotes blocked true
T11665 29319-29327 Negative_regulation denotes inhibits
T11666 29332-29342 Positive_regulation denotes activation
T11667 29346-29349 Protein denotes Akt true
T11668 29432-29435 Protein denotes Akt
T11669 29583-29593 Positive_regulation denotes activation
T11670 29597-29600 Protein denotes Akt
T11671 29644-29648 Protein denotes LMP1
T11672 29762-29776 Phosphorylation denotes phosphorylated
T11673 29777-29780 Protein denotes Akt
T11674 29782-29787 Protein denotes Stat3 true
T11675 29809-29813 Protein denotes IκBα true
T11676 29865-29872 Negative_regulation denotes blocked true
T11677 29873-29888 Phosphorylation denotes phosphorylation true true
T11678 29892-29895 Protein denotes Akt
T11679 29901-29915 Phosphorylation denotes phosphorylated true true
T11680 29916-29919 Protein denotes Akt
T11681 29954-29968 Phosphorylation denotes Phosphorylated
T11682 29969-29974 Protein denotes Stat3
T11683 29979-29983 Protein denotes IκBα
T11684 30066-30073 Binding denotes targets
T11685 30074-30077 Protein denotes Akt
T11686 30087-30090 Protein denotes Akt true
T11687 30091-30101 Positive_regulation denotes activation true
T11688 31595-31599 Protein denotes LMP1 true
T11689 31775-31789 Phosphorylation denotes Phosphorylated
T11690 31790-31793 Protein denotes Akt
T11691 31795-31800 Protein denotes Stat3
T11692 31812-31816 Protein denotes IκBα
T11693 31836-31841 Positive_regulation denotes up to true
T11694 31979-31983 Protein denotes LMP1
T11695 32046-32053 Regulation denotes effects
T11696 32057-32067 Positive_regulation denotes activation
T11697 32071-32074 Protein denotes Akt
T11698 32078-32083 Protein denotes Stat3
T11699 32100-32108 Negative_regulation denotes inhibits true
T11700 32109-32119 Positive_regulation denotes activation
T11701 32123-32128 Protein denotes Stat3
T11702 32173-32177 Protein denotes JAK2
T11703 32261-32270 Positive_regulation denotes activated
T11704 32271-32276 Protein denotes Stat3
T11705 32294-32298 Protein denotes LMP1
T11706 32486-32500 Phosphorylation denotes Phosphorylated
T11707 32501-32504 Protein denotes Akt
T11708 32506-32511 Protein denotes Stat3
T11709 32523-32527 Protein denotes IκBα
T11710 32693-32702 Negative_regulation denotes inhibitor
T11711 32706-32711 Protein denotes Stat3
T11712 32760-32770 Positive_regulation denotes activation
T11713 32774-32777 Protein denotes Akt
T11714 32779-32784 Protein denotes Stat3
T11715 32799-32803 Protein denotes IκBα
T11716 32818-32826 Regulation denotes affected
T11717 32867-32877 Negative_regulation denotes inhibition
T11718 32881-32886 Protein denotes Stat3
T11719 32912-32916 Protein denotes LMP1
T11720 32964-32969 Protein denotes Stat3
T11721 32970-32980 Negative_regulation denotes inhibition
T11722 33024-33027 Protein denotes Akt
T11723 33048-33052 Protein denotes LMP1
T11724 33124-33128 Protein denotes LMP1
T11725 33254-33263 Negative_regulation denotes inhibitor
T11726 33267-33271 Protein denotes MEK1
T11727 33272-33273 Protein denotes 2
T11728 33491-33495 Protein denotes LMP1
T11729 33583-33587 Protein denotes LMP1
T11730 33756-33766 Positive_regulation denotes activation
T11731 33770-33773 Protein denotes Akt
T11732 33785-33790 Protein denotes Stat3
T11733 33900-33909 Negative_regulation denotes inhibitor
T11734 33913-33917 Protein denotes mTOR
T11735 34013-34017 Protein denotes mTOR
T11736 34025-34033 Regulation denotes targeted
T11737 34037-34040 Protein denotes Akt
T11738 34041-34051 Positive_regulation denotes activation
T11739 34055-34059 Protein denotes LMP1
T14191 34182-34186 Protein denotes LMP1
T14192 34224-34228 Protein denotes LMP1
T14193 34334-34340 Positive_regulation denotes higher
T14194 34341-34351 Gene_expression denotes expression
T14195 34362-34366 Protein denotes LMP1
T14196 34403-34407 Protein denotes LMP1
T14197 34548-34552 Protein denotes LMP1
T14198 34660-34664 Protein denotes LMP1
T14199 34758-34762 Protein denotes LMP1
T14200 34863-34867 Protein denotes LMP1
T14201 34999-35006 Positive_regulation denotes induced
T14202 35010-35014 Protein denotes LMP1
T14203 35076-35080 Protein denotes CD40
T14204 35081-35090 Negative_regulation denotes deficient true
T14205 35226-35230 Protein denotes CD40
T14206 35244-35248 Protein denotes LMP1
T14207 35333-35343 Gene_expression denotes expression
T14208 35347-35351 Protein denotes LMP1
T14209 35556-35560 Protein denotes LMP1
T14210 35620-35624 Protein denotes LMP2
T14211 35794-35798 Protein denotes LMP2
T14212 35937-35941 Protein denotes LMP2
T14213 36090-36094 Protein denotes LMP1
T14214 36164-36168 Protein denotes LMP1
T14215 36360-36364 Protein denotes CD40
T14216 37076-37080 Protein denotes LMP1
T14217 37084-37093 Gene_expression denotes expressed
T14218 37199-37207 Positive_regulation denotes elevated
T14219 37208-37218 Gene_expression denotes expression
T14220 37222-37226 Protein denotes LMP1
T14221 37505-37514 Positive_regulation denotes activated
T14222 37518-37522 Protein denotes LMP1
T14223 37644-37648 Protein denotes LMP1
T14224 37832-37844 Positive_regulation denotes upregulation true
T14225 37848-37852 Protein denotes IL10
T14226 37867-37877 Positive_regulation denotes activation true
T14227 37881-37886 Protein denotes Stat3
T14228 37920-37930 Positive_regulation denotes activation
T14229 37934-37937 Protein denotes Akt
T14230 37949-37954 Protein denotes Stat3
T14231 37983-37992 Positive_regulation denotes Induction
T14232 37996-38000 Protein denotes IL10
T14233 38194-38198 Protein denotes LMP1
T14234 38217-38226 Positive_regulation denotes stimulate
T14235 38227-38231 Protein denotes IL10
T14236 38232-38242 Gene_expression denotes expression
T14237 38311-38316 Protein denotes Stat3
T14238 38335-38344 Positive_regulation denotes activated
T14239 38372-38381 Positive_regulation denotes induction
T14240 38385-38389 Protein denotes IL10
T14241 38402-38409 Positive_regulation denotes enhance
T14242 38410-38415 Protein denotes Stat3
T14243 38416-38426 Positive_regulation denotes activation
T14244 38434-38444 Positive_regulation denotes contribute true
T14245 38454-38458 Protein denotes IL10
T14246 38490-38494 Protein denotes LMP1
T14247 38628-38632 Protein denotes LMP1
T14248 38660-38664 Protein denotes LMP1
T14249 38665-38673 Gene_expression denotes positive
T14250 38744-38748 Protein denotes CD40
T14251 38781-38790 Negative_regulation denotes deficient
T14252 38795-38799 Protein denotes cRel
T14253 38807-38810 Protein denotes p85
T14254 38887-38891 Protein denotes CD40
T14255 38892-38900 Binding denotes ligation
T14256 38940-38944 Protein denotes cRel
T14257 38961-38970 Positive_regulation denotes activated
T14258 38993-38997 Protein denotes LMP1
T14259 39036-39046 Positive_regulation denotes activation
T14260 39050-39054 Protein denotes cRel
T14261 39143-39147 Protein denotes CD40
T14262 39171-39175 Protein denotes LMP1
T14263 39220-39230 Positive_regulation denotes activation
T14264 39234-39237 Protein denotes Akt
T14265 39280-39284 Protein denotes cRel
T14266 39286-39290 Protein denotes CD40
T14267 39337-39346 Negative_regulation denotes inhibitor
T14268 39347-39350 Protein denotes p27
T14269 39392-39396 Protein denotes LMP1
T14270 39421-39430 Negative_regulation denotes decreased
T14271 39441-39444 Protein denotes p27
T14272 39450-39465 Phosphorylation denotes phosphorylation
T14273 39469-39471 Protein denotes Rb
T14274 39476-39485 Positive_regulation denotes increased
T14275 39486-39490 Protein denotes Cdk2
T14276 39518-39522 Protein denotes LMP1
T14277 39556-39558 Protein denotes Rb
T14278 39697-39700 Protein denotes Akt
T14279 39701-39711 Positive_regulation denotes activation
T14280 39794-39797 Protein denotes Akt
T14281 39798-39807 Negative_regulation denotes inhibitor
T14282 39822-39831 Positive_regulation denotes activated
T14283 39832-39836 Protein denotes pAkt
T14284 39845-39849 Positive_regulation denotes lead
T14285 39853-39868 Phosphorylation denotes phosphorylation
T14286 39873-39885 Negative_regulation denotes inactivation
T14287 39911-39915 Protein denotes GSK3
T14288 40074-40078 Protein denotes LMP1
T14289 40123-40127 Protein denotes LMP1
T14290 40237-40246 Positive_regulation denotes activated
T14291 40247-40253 Protein denotes p-mTOR
T14292 40308-40311 Protein denotes Akt
T14293 40386-40396 Negative_regulation denotes inhibition
T14294 40404-40409 Protein denotes Fox01
T14295 40486-40491 Protein denotes FoxO1
T14296 40523-40530 Negative_regulation denotes inhibit
T14297 40531-40541 Gene_expression denotes expression
T14298 40545-40549 Protein denotes bcl6
T14299 40652-40656 Protein denotes CD40
T14300 40750-40754 Protein denotes CD40
T14301 40777-40781 Protein denotes LMP1
T14302 40861-40865 Protein denotes LMP1
T18281 42576-42580 Protein denotes LMP1
T18282 42729-42733 Protein denotes LMP1
T18596 43727-43731 Protein denotes CD19
T18597 44082-44086 Protein denotes CD19
T18598 44186-44189 Protein denotes IL4
T18599 44232-44236 Protein denotes IL10
T18600 44274-44278 Protein denotes IL10
T19030 44736-44739 Protein denotes IL4
T19031 44823-44826 Protein denotes IL4
T19032 45151-45154 Protein denotes IL4
T19033 45176-45179 Protein denotes IL4
T19630 46086-46090 Protein denotes LMP1
T19631 46135-46139 Protein denotes LMP1
T19632 46284-46288 Protein denotes LMP1
T19633 46666-46673 Phosphorylation denotes Phospho
T19634 46674-46679 Protein denotes Stat3
T20328 47595-47599 Protein denotes CD19
T20329 48343-48350 Protein denotes Rnase A
T20330 48355-48357 Protein denotes T1
T20765 48835-48853 Protein denotes Taq DNA polymerase
T21025 49932-49942 Protein denotes peroxidase
T21406 50409-50413 Protein denotes CD19
T21407 50459-50463 Protein denotes LMP1
T21408 50508-50510 Protein denotes Rb
T21409 50531-50535 Protein denotes Cdk2
T21410 50618-50621 Protein denotes CD5
T21411 50678-50682 Protein denotes LMP1
T21412 50757-50761 Protein denotes pAkt
T21413 50777-50783 Protein denotes pGSK3α
T21414 50784-50785 Protein denotes β
T21415 50802-50808 Protein denotes pStat3
T21416 50824-50830 Protein denotes pStat6
T21417 50846-50851 Protein denotes pmTOR
T21418 50868-50873 Protein denotes Stat6
T21419 50880-50883 Protein denotes Akt
T21420 50890-50895 Protein denotes FoxO1
T21421 50906-50909 Protein denotes p27
T21422 50958-50963 Protein denotes Stat3
T21423 50978-50982 Protein denotes IκBα
T21424 51005-51012 Protein denotes β actin
T21425 51083-51087 Protein denotes GSK3
T21426 51142-51145 Protein denotes pRb
T21787 8478-8482 Positive_regulation denotes High
T21788 8483-8487 Protein denotes LMP1
T21789 8488-8498 Gene_expression denotes Expression
T21790 8543-8547 Protein denotes LMP1
T21791 8548-8558 Gene_expression denotes expression
T21792 8611-8615 Protein denotes CD19
T21793 8697-8701 Protein denotes LMP1
T21794 8789-8793 Protein denotes LMP1
T22085 10554-10558 Protein denotes LMP1
T22086 10673-10677 Protein denotes LMP1
T22087 10718-10722 Protein denotes CD19
T22088 10736-10739 Protein denotes CD5
T22089 10855-10859 Protein denotes LMP1
T22090 10924-10928 Protein denotes LMP1
T22091 11117-11121 Protein denotes LMP1
T22092 11155-11159 Protein denotes CD19
T22093 11160-11163 Protein denotes CD5
T22094 11190-11194 Protein denotes CD19
T22095 11195-11198 Protein denotes CD5
T22096 11332-11336 Protein denotes LMP1
T22097 11436-11440 Protein denotes CD19
T22098 11464-11468 Protein denotes LMP1
T22634 14367-14371 Protein denotes LMP1
T22635 14465-14469 Protein denotes LMP1
T22636 14568-14571 Protein denotes IL4
T22637 14769-14773 Protein denotes LMP1
T22638 14813-14817 Protein denotes LMP1
T22639 14861-14865 Protein denotes CD19
T22640 14897-14901 Protein denotes LMP1
T22641 15006-15009 Protein denotes IL4
T22642 15079-15083 Protein denotes LMP1
T22643 15135-15138 Protein denotes IL4
T22644 15193-15197 Protein denotes LMP1
T23109 17955-17959 Protein denotes LMP1 true
T23110 18011-18014 Protein denotes IL4
T23111 18015-18020 Protein denotes Stat6
T23112 18073-18076 Protein denotes IL4
T23113 18105-18109 Protein denotes CD19
T23114 18124-18128 Protein denotes LMP1
T23115 18157-18160 Protein denotes L32
T23116 18165-18170 Protein denotes GAPDH
T23117 18315-18319 Protein denotes LMP1
T23118 18340-18349 Positive_regulation denotes activated
T23119 18350-18356 Protein denotes pStat6
T23120 18382-18386 Protein denotes CD19
T23121 18465-18468 Protein denotes IL4
T23122 18636-18640 Protein denotes LMP1
T23123 18681-18684 Protein denotes IL4
T23124 18713-18716 Protein denotes IL4
T23125 18807-18811 Protein denotes LMP1
T23678 22890-22894 Protein denotes LMP1
T23679 22895-22906 Positive_regulation denotes Upregulates
T23680 22907-22911 Protein denotes IL10
T23681 22912-22922 Gene_expression denotes Expression true
T23682 22942-22951 Positive_regulation denotes Activates true
T23683 22952-22957 Protein denotes Stat3 true
T23684 22971-22981 Gene_expression denotes expression true
T23685 22985-22989 Protein denotes IL10 true
T23686 22991-22995 Protein denotes IL15
T23687 23001-23005 Protein denotes IFNγ
T23688 23021-23025 Protein denotes LMP1
T23689 23046-23050 Protein denotes CD19
T23690 23278-23281 Protein denotes L32
T23691 23296-23299 Protein denotes L32
T23692 23391-23400 Positive_regulation denotes activated
T23693 23401-23407 Protein denotes pStat3
T23694 23429-23433 Protein denotes CD19
T23695 23448-23452 Protein denotes LMP1
T23696 23539-23543 Protein denotes IL10
T23697 23572-23576 Protein denotes IL10
T23698 23657-23661 Protein denotes LMP1
T23699 23742-23747 Protein denotes Stat3
T23700 23824-23833 Positive_regulation denotes activated
T23701 23842-23848 Protein denotes pStat3
T23702 23874-23878 Protein denotes LMP1
T24322 25723-25727 Protein denotes LMP1
T24323 25738-25741 Protein denotes Akt
T24324 25772-25774 Protein denotes Rb true true
T24325 25845-25849 Protein denotes CD19 true true
T24326 25879-25883 Protein denotes LMP1 true
T24327 25904-25907 Protein denotes Akt true
T24328 25935-25944 Positive_regulation denotes activated
T24329 25945-25949 Protein denotes pAkt
T24330 25984-25995 Negative_regulation denotes inactivated
T24331 25996-26002 Protein denotes pGSK3α
T24332 26003-26004 Protein denotes β
T24333 26014-26023 Positive_regulation denotes activated
T24334 26024-26030 Protein denotes p-mTOR
T24335 26052-26057 Protein denotes FoxO1
T24336 26112-26116 Protein denotes GSK3
T24337 26252-26254 Protein denotes Rb
T24338 26276-26285 Positive_regulation denotes activated
T24339 26286-26289 Protein denotes pRb
T24340 26311-26315 Protein denotes Cdk2
T24341 26328-26337 Negative_regulation denotes inhibitor
T24342 26338-26341 Protein denotes p27
T24765 30201-30204 Protein denotes Akt
T24766 30216-30221 Protein denotes Stat3
T24767 30347-30351 Protein denotes LMP1
T24768 30387-30391 Protein denotes LMP1
T24769 30486-30490 Protein denotes mTOR
T24770 30504-30507 Protein denotes Akt
T24771 30523-30527 Protein denotes MEK1
T24772 30528-30529 Protein denotes 2
T24773 30558-30563 Protein denotes Stat3
T24774 30739-30743 Protein denotes LMP1
T24775 30796-30800 Protein denotes LMP1
T24776 30859-30863 Protein denotes LMP1
T25218 30934-30937 Protein denotes Akt
T25219 30949-30954 Protein denotes Stat3
T25220 31068-31072 Protein denotes LMP1
T25221 31098-31101 Protein denotes Akt
T25222 31113-31118 Protein denotes Stat3
T25223 31157-31160 Protein denotes Akt
T25224 31161-31170 Negative_regulation denotes inhibitor
T25225 31228-31233 Protein denotes Stat3
T25226 31234-31244 Negative_regulation denotes inhibitors
T25227 31365-31370 Protein denotes Stat3
T25506 16951-16955 Protein denotes LMP1
R10746 T14194 T14193 themeOf expression,higher
R10747 T14195 T14194 themeOf LMP1,expression
R10748 T14203 T14204 themeOf CD40,deficient
R10749 T14208 T14207 themeOf LMP1,expression
R10750 T14216 T14217 themeOf LMP1,expressed
R10751 T14219 T14218 themeOf expression,elevated
R10752 T14220 T14219 themeOf LMP1,expression
R10753 T14225 T14224 themeOf IL10,upregulation
R10754 T14232 T14231 themeOf IL10,Induction
R10755 T14233 T14234 causeOf LMP1,stimulate
R10756 T14235 T14236 themeOf IL10,expression
R10757 T14236 T14234 themeOf expression,stimulate
R10758 T14237 T14238 themeOf Stat3,activated
R10759 T14239 T14244 causeOf induction,contribute
R10760 T14239 T14241 causeOf induction,enhance
R10761 T14240 T14239 themeOf IL10,induction
R10762 T14242 T14243 themeOf Stat3,activation
R10763 T14243 T14241 themeOf activation,enhance
R10764 T14248 T14249 themeOf LMP1,positive
R10765 T14252 T14251 themeOf cRel,deficient
R10766 T14253 T14251 themeOf p85,deficient
R10767 T14254 T14255 themeOf CD40,ligation
R10768 T14256 T14257 themeOf cRel,activated
R10769 T14260 T14259 themeOf cRel,activation
R10770 T14264 T14263 themeOf Akt,activation
R10771 T14268 T14267 themeOf p27,inhibitor
R10772 T14272 T14270 themeOf phosphorylation,decreased
R10773 T14273 T14272 themeOf Rb,phosphorylation
R10774 T14275 T14274 themeOf Cdk2,increased
R10775 T14278 T14279 themeOf Akt,activation
R10776 T14280 T14281 themeOf Akt,inhibitor
R10777 T14283 T14282 themeOf pAkt,activated
R10778 T14283 T14284 causeOf pAkt,lead
R10779 T14285 T14284 themeOf phosphorylation,lead
R10780 T14286 T14284 themeOf inactivation,lead
R10781 T14287 T14285 themeOf GSK3,phosphorylation
R10782 T14287 T14286 themeOf GSK3,inactivation
R10783 T14291 T14290 themeOf p-mTOR,activated
R10784 T14294 T14293 themeOf Fox01,inhibition
R10785 T14297 T14296 themeOf expression,inhibit
R10786 T14298 T14297 themeOf bcl6,expression
R10787 T14304 T14303 themeOf bcl6,downregulation
R10788 T14306 T14305 themeOf LMP1,expression
R10789 T14307 T14305 themeOf bcl6,expression
R10790 T14310 T14309 themeOf Akt,activation
R10791 T14312 T14311 themeOf Fox01,lack
R10792 T14313 T14314 causeOf LMP1,affects
R10793 T14315 T14314 themeOf bcl6,affects
R10794 T14318 T14321 causeOf loss,correlated
R10 T22 T23 causeOf Latent Membrane Protein 1,Activates
R11 T27 T26 equivalentTo LMP1,Latent membrane protein 1
R425 T608 T610 themeOf Latent membrane protein 1,expressed
R426 T609 T608 equivalentTo LMP1,Latent membrane protein 1
R427 T615 T616 themeOf CD40,interacts
R428 T617 T616 themeOf CD40 ligand,interacts
R429 T617 T618 themeOf CD40 ligand,expressed
R430 T620 T622 themeOf LMP1,interact
R431 T621 T622 themeOf CD40,interact
R432 T623 T622 themeOf tumor necrosis factor,interact
R433 T628 T629 themeOf CD40,ligation
R434 T633 T632 themeOf CD40,deficient
R435 T634 T632 themeOf CD40L,deficient
R436 T635 T636 partOf cytoplasmic regions,CD40
R437 T638 T637 themeOf TRAF6,bind
R438 T639 T637 themeOf TRAFs2,bind
R439 T640 T637 themeOf 3,bind
R440 T641 T637 themeOf 5,bind
R441 T643 T644 themeOf CD40,deficient
R442 T645 T646 themeOf LMP1,recruits
R443 T647 T646 themeOf TRAFs 1,recruits
R444 T648 T646 themeOf 2,recruits
R445 T649 T646 themeOf 3,recruits
R446 T650 T646 themeOf 5,recruits
R447 T651 T646 themeOf TRAF6,recruits
R448 T652 T651 partOf C-terminal activation regions 1,TRAF6
R449 T652 T647 partOf C-terminal activation regions 1,TRAFs 1
R450 T652 T645 partOf C-terminal activation regions 1,LMP1
R451 T652 T646 themeOf C-terminal activation regions 1,recruits
R452 T653 T646 themeOf 2 domains,recruits
R453 T653 T645 partOf 2 domains,LMP1
R454 T655 T656 themeOf LMP1,expressed
R455 T656 T657 themeOf expressed,under the control
R456 T660 T659 themeOf LMP1,express
R457 T664 T663 themeOf Akt,activated
R458 T666 T665 themeOf cRel,activation
R459 T671 T672 themeOf LMP1,positive
R460 T675 T674 themeOf activated,absence
R461 T676 T675 themeOf Stat6,activated
R462 T679 T678 themeOf Stat3,activation
R2429 T3115 T3116 themeOf LMP1,Expression
R2430 T3117 T3118 themeOf LMP1,expression
R2431 T3120 T3121 themeOf LMP1,expression
R2432 T3122 T3123 themeOf LMP1,expression
R2433 T3127 T3128 themeOf LMP1,expression
R2434 T3131 T3130 themeOf LMP1,expression
R2435 T3133 T3134 themeOf LMP1,expression
R2436 T3137 T3138 themeOf LMP1,expression
R2437 T3140 T3139 themeOf LMP1,intense
R2438 T3144 T3145 themeOf LMP1,expression
R2439 T3145 T3143 themeOf expression,increase
R2440 T3147 T3146 themeOf LMP1,expressing
R2441 T3149 T3150 themeOf LMP1,expression
R2442 T3150 T3148 themeOf expression,high
R2443 T3152 T3151 themeOf LMP1,increased
R3145 T4046 T4047 themeOf LMP1,expression
R3146 T4066 T4065 themeOf LMP1,expression
R4298 T5433 T5434 themeOf CD40,ligation
R4299 T5438 T5437 themeOf IL4,absence
R4300 T5442 T5443 themeOf CD40,ligation
R4301 T5443 T5441 themeOf ligation,lack
R4302 T5445 T5447 themeOf absence,enhanced
R4303 T5446 T5445 themeOf IL4,absence
R4304 T5451 T5450 themeOf IL4,absence
R4305 T5465 T5464 themeOf LMP1,expression
R4306 T5466 T5467 themeOf LMP1,expression
R4307 T5469 T5470 themeOf LMP1,negative
R4308 T5472 T5471 themeOf LMP1,express
R4309 T5473 T5471 themeOf LMP1,express
R4310 T5474 T5471 themeOf LMP1,express
R4311 T5475 T5471 themeOf LMP1,express
R4878 T6326 T6327 themeOf IL4,expression
R4879 T6327 T6325 themeOf expression,due
R4880 T6328 T6329 themeOf IL4,transcription
R4881 T6330 T6331 themeOf IL4,transcription
R4882 T6332 T6333 themeOf IL4,transcription
R4883 T6339 T6338 themeOf Stat6,Activated
R4884 T6340 T6339 equivalentTo pStat6,Stat6
R4885 T6344 T6345 causeOf IL4,induced
R4886 T6346 T6347 themeOf Stat6,phosphorylation
R4887 T6347 T6345 themeOf phosphorylation,induced
R5598 T7312 T7315 causeOf LMP1,Activates
R5599 T7312 T7313 causeOf LMP1,Upregulates
R5600 T7314 T7313 themeOf IL10,Upregulates
R5601 T7316 T7315 themeOf Stat3,Activates
R5602 T7330 T7329 themeOf IL10,Transcription
R5603 T7331 T7329 themeOf IL15,Transcription
R5604 T7332 T7329 themeOf IFNγ,Transcription
R5605 T7335 T7334 themeOf expression,difference
R5606 T7336 T7335 themeOf IL15,expression
R5607 T7337 T7335 themeOf IFNγ,expression
R5608 T7340 T7343 themeOf upregulation,induced
R5609 T7341 T7340 themeOf IL15,upregulation
R5610 T7342 T7340 themeOf IFNγ,upregulation
R5611 T7344 T7345 themeOf LMP1,expression
R5612 T7345 T7343 causeOf expression,induced
R5613 T7350 T7349 themeOf IL15,Production
R5614 T7351 T7349 themeOf IFNγ,Production
R5615 T7353 T7352 themeOf IL10,upregulation
R5616 T7355 T7356 themeOf IL10,upregulation
R5617 T7356 T7354 themeOf upregulation,effects
R5618 T7360 T7359 themeOf phosphorylated,increased
R5619 T7361 T7359 themeOf activated,increased
R5620 T7362 T7361 themeOf Stat3,activated
R5621 T7362 T7363 themeOf Stat3,target
R5622 T7364 T7363 themeOf IL10,target
R5623 T7365 T7366 themeOf IL10,induction
R5624 T7367 T7368 themeOf Stat3,activation
R5625 T7369 T7371 themeOf activation,induced
R5626 T7370 T7369 themeOf Stat3,activation
R5627 T7372 T7371 causeOf IL10,induced
R5628 T7373 T7374 themeOf Stat3,activation
R5629 T7375 T7376 themeOf LMP1,expression
R5630 T7377 T7378 themeOf IL10,induction
R5631 T7379 T7381 themeOf induction,affected
R5632 T7380 T7379 themeOf IL10,induction
R5633 T7382 T7381 causeOf LMP1,affected
R5634 T7385 T7384 themeOf Stat3,activation
R5635 T7387 T7388 themeOf pStat3,activated
R5636 T7390 T7391 causeOf IL10,enhanced
R5637 T7392 T7393 themeOf pStat3,activation
R5638 T7393 T7391 themeOf activation,enhanced
R5639 T7395 T7396 themeOf Stat3,activation
R5640 T7396 T7397 themeOf activation,enhanced
R5641 T7398 T7399 themeOf IL10,induction
R5642 T7399 T7397 causeOf induction,enhanced
R5643 T7403 T7404 locationOf Nuclear,translocation
R5644 T7405 T7404 themeOf pStat3,translocation
R5645 T7406 T7408 locationOf nuclear,detected
R5646 T7407 T7408 themeOf pStat3,detected
R5647 T7409 T7411 locationOf nuclear,detectable
R5648 T7410 T7411 themeOf pStat3,detectable
R5649 T7415 T7414 themeOf pStat3,activation
R5650 T7417 T7414 themeOf Stat3,activation
R7305 T9556 T9555 themeOf Akt,activation
R7306 T9558 T9557 themeOf pAkt,activated
R7307 T9566 T9565 themeOf pAkt,increased
R7308 T9567 T9568 themeOf LMP1,positive
R7309 T9570 T9569 themeOf pAkt,increase
R7310 T9573 T9572 equivalentTo GSK3,glycogen synthase kinase 3
R7311 T9577 T9576 themeOf phosphorylated,increased
R7312 T9578 T9577 themeOf GSK3,phosphorylated
R7313 T9579 T9580 themeOf GSK3,target
R7314 T9582 T9581 themeOf Akt,activated
R7315 T9582 T9580 themeOf Akt,target
R7316 T9585 T9584 themeOf Akt,activation
R7317 T9587 T9586 themeOf GSK3,phosphorylation
R7318 T9589 T9588 themeOf Akt,activated
R7319 T9591 T9590 themeOf GSK3,phosphorylated
R7320 T9593 T9592 themeOf GSK3,regulation
R7321 T9594 T9595 themeOf Akt,targets
R7322 T9596 T9595 themeOf p-mTOR,targets
R7323 T9597 T9599 themeOf Activated,increased
R7324 T9598 T9597 themeOf p-mTOR,Activated
R7325 T9598 T9599 themeOf p-mTOR,increased
R7326 T9602 T9603 causeOf LMP1,induced
R7327 T9604 T9605 themeOf Akt,activation
R7328 T9605 T9603 themeOf activation,induced
R7329 T9609 T9610 themeOf FoxO1,degradation
R7330 T9612 T9611 themeOf FoxO1,degradation
R7331 T9614 T9615 themeOf FoxO1,decreased
R7332 T9618 T9617 themeOf Akt,target
R7333 T9619 T9620 themeOf Akt,activation
R7334 T9620 T9621 causeOf activation,induce
R7335 T9622 T9623 themeOf FoxO1,degradation
R7336 T9623 T9621 themeOf degradation,induce
R7337 T9625 T9626 causeOf Akt,regulator
R7338 T9627 T9626 themeOf FoxO1,regulator
R7339 T9629 T9628 themeOf expression,induce
R7340 T9631 T9630 themeOf p27,inhibitor
R7341 T9631 T9629 themeOf p27,expression
R7342 T9634 T9633 themeOf expression,decreased
R7343 T9647 T9646 themeOf pRb,enhanced
R7344 T9652 T9651 themeOf increased,led
R7345 T9653 T9652 themeOf Rb,increased
R7346 T9657 T9656 themeOf p27,decreased
R7347 T9661 T9660 themeOf FoxO1,loss
R7348 T9663 T9662 themeOf p27,decreased
R8796 T11660 T11659 themeOf Akt,inhibitors
R8797 T11661 T11659 themeOf Stat3,inhibitors
R8798 T11662 T11659 themeOf mTOR,inhibitors
R8799 T11666 T11665 themeOf activation,inhibits
R8800 T11667 T11666 themeOf Akt,activation
R8801 T11670 T11669 themeOf Akt,activation
R8802 T11673 T11672 themeOf Akt,phosphorylated
R8803 T11674 T11672 themeOf Stat3,phosphorylated
R8804 T11677 T11676 themeOf phosphorylation,blocked
R8805 T11678 T11677 themeOf Akt,phosphorylation
R8806 T11680 T11679 themeOf Akt,phosphorylated
R8807 T11682 T11681 themeOf Stat3,Phosphorylated
R8808 T11683 T11681 themeOf IκBα,Phosphorylated
R8809 T11685 T11684 themeOf Akt,targets
R8810 T11686 T11687 themeOf Akt,activation
R8811 T11690 T11689 themeOf Akt,Phosphorylated
R8812 T11691 T11689 themeOf Stat3,Phosphorylated
R8813 T11691 T11693 themeOf Stat3,up to
R8814 T11692 T11689 themeOf IκBα,Phosphorylated
R8815 T11692 T11693 themeOf IκBα,up to
R8816 T11696 T11695 themeOf activation,effects
R8817 T11697 T11696 themeOf Akt,activation
R8818 T11698 T11696 themeOf Stat3,activation
R8819 T11700 T11699 themeOf activation,inhibits
R8820 T11701 T11700 themeOf Stat3,activation
R8821 T11704 T11703 themeOf Stat3,activated
R8822 T11707 T11706 themeOf Akt,Phosphorylated
R8823 T11708 T11706 themeOf Stat3,Phosphorylated
R8824 T11709 T11706 themeOf IκBα,Phosphorylated
R8825 T11711 T11710 themeOf Stat3,inhibitor
R8826 T11712 T11716 themeOf activation,affected
R8827 T11713 T11712 themeOf Akt,activation
R8828 T11718 T11717 themeOf Stat3,inhibition
R8829 T11720 T11721 themeOf Stat3,inhibition
R8830 T11726 T11725 themeOf MEK1,inhibitor
R8831 T11727 T11725 themeOf 2,inhibitor
R8832 T11734 T11733 themeOf mTOR,inhibitor
R8833 T11735 T11736 themeOf mTOR,targeted
R8834 T11737 T11738 themeOf Akt,activation
R15242 T19634 T19633 themeOf Stat3,Phospho
R17031 T21788 T21789 themeOf LMP1,Expression
R17032 T21789 T21787 themeOf Expression,High
R17033 T21790 T21791 themeOf LMP1,expression
R18035 T23119 T23118 themeOf pStat6,activated
R18450 T23678 T23682 causeOf LMP1,Activates
R18451 T23678 T23679 causeOf LMP1,Upregulates
R18452 T23680 T23681 themeOf IL10,Expression
R18453 T23681 T23679 themeOf Expression,Upregulates
R18454 T23683 T23682 themeOf Stat3,Activates
R18455 T23685 T23684 themeOf IL10,expression
R18456 T23686 T23684 themeOf IL15,expression
R18457 T23687 T23684 themeOf IFNγ,expression
R18458 T23693 T23692 themeOf pStat3,activated
R18459 T23701 T23700 themeOf pStat3,activated
R18927 T24329 T24328 themeOf pAkt,activated
R18928 T24331 T24330 themeOf pGSK3α,inactivated
R18929 T24332 T24330 themeOf β,inactivated
R18930 T24334 T24333 themeOf p-mTOR,activated
R18931 T24339 T24338 themeOf pRb,activated
R18932 T24340 T24341 themeOf Cdk2,inhibitor
R18933 T24342 T24341 themeOf p27,inhibitor
R19559 T25223 T25224 themeOf Akt,inhibitor
R19560 T25225 T25226 themeOf Stat3,inhibitors
R10796 T14320 T14318 themeOf expression,loss
R10797 T14322 T14321 themeOf loss,correlated
R10798 T14323 T14322 themeOf p27,loss
R10799 T14331 T14330 themeOf p27,decreased
R10795 T14319 T14320 themeOf FoxO1,expression