PMC:194730 / 7171-18861 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T2443	9-16	NN	denotes	Annexin
T2444	17-19	NN	denotes	A7
T2445	20-30	NN	denotes	expression
T2446	31-33	IN	denotes	in
T2447	34-37	JJ	denotes	red
T2448	44-49	NNS	denotes	cells
T2449	38-43	NN	denotes	blood
T2450	49-51	,	denotes	,
T2451	51-54	JJ	denotes	red
T2452	61-65	NN	denotes	cell
T2453	55-60	NN	denotes	blood
T2454	66-73	VBN	denotes	derived
T2455	74-85	NNS	denotes	exovesicles
T2456	86-89	CC	denotes	and
T2457	90-92	IN	denotes	in
T2458	93-102	NNS	denotes	platelets
T2459	102-343	sentence	denotes	Salzer et al. recently reported the presence of the 47 kDa isoform of annexin A7 and its partner sorcin in micro- and nanovesicles derived from red blood cells where they are located in the lumen and are also enriched in membrane rafts [7].
T2460	103-109	NNP	denotes	Salzer
T2461	126-134	VBD	denotes	reported
T2462	110-112	FW	denotes	et
T2463	113-116	FW	denotes	al.
T2464	117-125	RB	denotes	recently
T2465	135-138	DT	denotes	the
T2466	139-147	NN	denotes	presence
T2467	148-150	IN	denotes	of
T2468	151-154	DT	denotes	the
T2469	162-169	NN	denotes	isoform
T2470	155-157	CD	denotes	47
T2471	158-161	NN	denotes	kDa
T2472	170-172	IN	denotes	of
T2473	173-180	NN	denotes	annexin
T2474	181-183	NN	denotes	A7
T2475	184-187	CC	denotes	and
T2476	188-191	PRP$	denotes	its
T2477	192-199	NN	denotes	partner
T2478	200-206	NN	denotes	sorcin
T2479	207-209	IN	denotes	in
T2480	210-215	NN	denotes	micro
T2481	215-216	HYPH	denotes	-
T2482	217-220	CC	denotes	and
T2483	221-233	NNS	denotes	nanovesicles
T2484	234-241	VBN	denotes	derived
T2485	242-246	IN	denotes	from
T2486	247-250	JJ	denotes	red
T2487	257-262	NNS	denotes	cells
T2488	251-256	NN	denotes	blood
T2489	263-268	WRB	denotes	where
T2490	278-285	VBN	denotes	located
T2491	269-273	PRP	denotes	they
T2492	274-277	VBP	denotes	are
T2493	286-288	IN	denotes	in
T2494	289-292	DT	denotes	the
T2495	293-298	NN	denotes	lumen
T2496	299-302	CC	denotes	and
T2497	303-306	VBP	denotes	are
T2498	312-320	VBN	denotes	enriched
T2499	307-311	RB	denotes	also
T2500	321-323	IN	denotes	in
T2501	324-332	NN	denotes	membrane
T2502	333-338	NNS	denotes	rafts
T2503	339-340	-LRB-	denotes	[
T2504	340-341	CD	denotes	7
T2505	341-342	-RRB-	denotes	]
T2506	342-343	.	denotes	.
T2507	343-437	sentence	denotes	We have now extended these findings and show here that the 51 kDa isoform is present as well.
T2508	344-346	PRP	denotes	We
T2509	356-364	VBN	denotes	extended
T2510	347-351	VBP	denotes	have
T2511	352-355	RB	denotes	now
T2512	365-370	DT	denotes	these
T2513	371-379	NNS	denotes	findings
T2514	380-383	CC	denotes	and
T2515	384-388	VBP	denotes	show
T2516	389-393	RB	denotes	here
T2517	394-398	IN	denotes	that
T2518	418-420	VBZ	denotes	is
T2519	399-402	DT	denotes	the
T2520	410-417	NN	denotes	isoform
T2521	403-405	CD	denotes	51
T2522	406-409	NN	denotes	kDa
T2523	421-428	JJ	denotes	present
T2524	429-431	RB	denotes	as
T2525	432-436	RB	denotes	well
T2526	436-437	.	denotes	.
T2527	437-548	sentence	denotes	In western blots of human red blood cells the 47 and 51 kDa isoforms were detected using mAb 203–217 (Fig. 1).
T2528	438-440	IN	denotes	In
T2529	512-520	VBN	denotes	detected
T2530	441-448	JJ	denotes	western
T2531	449-454	NNS	denotes	blots
T2532	455-457	IN	denotes	of
T2533	458-463	JJ	denotes	human
T2534	474-479	NNS	denotes	cells
T2535	464-467	JJ	denotes	red
T2536	468-473	NN	denotes	blood
T2537	480-483	DT	denotes	the
T2538	498-506	NNS	denotes	isoforms
T2539	484-486	CD	denotes	47
T2540	494-497	NN	denotes	kDa
T2541	487-490	CC	denotes	and
T2542	491-493	CD	denotes	51
T2543	507-511	VBD	denotes	were
T2544	521-526	VBG	denotes	using
T2545	527-530	NN	denotes	mAb
T2546	531-538	CD	denotes	203–217
T2547	539-540	-LRB-	denotes	(
T2548	540-544	NN	denotes	Fig.
T2549	545-546	CD	denotes	1
T2550	546-547	-RRB-	denotes	)
T2551	547-548	.	denotes	.
T2552	548-695	sentence	denotes	The 47 kDa isoform was detected in silver stained gels and its identity with annexin A7 confirmed by peptide mass fingerprinting (data not shown).
T2553	549-552	DT	denotes	The
T2606	1189-1194	IN	denotes	along
T2607	1195-1199	IN	denotes	with
T2608	1200-1204	NN	denotes	raft
T2609	1205-1212	NNS	denotes	domains
T2610	1212-1214	,	denotes	,
T2611	1214-1221	NN	denotes	annexin
T2612	1222-1224	NN	denotes	A7
T2613	1231-1232	DT	denotes	a
T2614	1233-1237	NN	denotes	role
T2615	1238-1240	IN	denotes	in
T2616	1241-1249	NN	denotes	membrane
T2617	1250-1262	NN	denotes	organization
T2618	1263-1266	CC	denotes	and
T2619	1267-1270	DT	denotes	the
T2620	1284-1291	NN	denotes	process
T2621	1271-1283	NN	denotes	vesiculation
T2622	1291-1292	.	denotes	.
T2623	1292-1427	sentence	denotes	To examine this, we analysed the ability of red blood cells derived from the annexin A7 knock out mice (anxA7-/-) to form exovesicles.
T2624	1293-1295	TO	denotes	To
T2625	1296-1303	VB	denotes	examine
T2626	1313-1321	VBD	denotes	analysed
T2627	1304-1308	DT	denotes	this
T2628	1308-1310	,	denotes	,
T2629	1310-1312	PRP	denotes	we
T2630	1322-1325	DT	denotes	the
T2631	1326-1333	NN	denotes	ability
T2632	1334-1336	IN	denotes	of
T2633	1337-1340	JJ	denotes	red
T2634	1347-1352	NNS	denotes	cells
T2635	1341-1346	NN	denotes	blood
T2636	1353-1360	VBN	denotes	derived
T2637	1361-1365	IN	denotes	from
T2638	1366-1369	DT	denotes	the
T2639	1391-1395	NNS	denotes	mice
T2640	1370-1377	NN	denotes	annexin
T2641	1378-1380	NN	denotes	A7
T2642	1381-1386	NN	denotes	knock
T2643	1387-1390	NN	denotes	out
T2644	1396-1397	-LRB-	denotes	(
T2645	1397-1402	NN	denotes	anxA7
T2646	1402-1403	SYM	denotes	-
T2647	1403-1404	HYPH	denotes	/
T2648	1404-1405	SYM	denotes	-
T2649	1405-1406	-RRB-	denotes	)
T2650	1407-1409	TO	denotes	to
T2651	1410-1414	VB	denotes	form
T2652	1415-1426	NNS	denotes	exovesicles
T2653	1426-1427	.	denotes	.
T2654	1427-1563	sentence	denotes	Because of better accessibility and larger available amounts that led to clear results, we included our data obtained with human blood.
T2655	1428-1435	IN	denotes	Because
T2656	1519-1527	VBD	denotes	included
T2657	1436-1438	IN	denotes	of
T2658	1439-1445	JJR	denotes	better
T2659	1446-1459	NN	denotes	accessibility
T2660	1460-1463	CC	denotes	and
T2661	1464-1470	JJR	denotes	larger
T2662	1481-1488	NNS	denotes	amounts
T2663	1471-1480	JJ	denotes	available
T2664	1489-1493	WDT	denotes	that
T2665	1494-1497	VBD	denotes	led
T2666	1498-1500	IN	denotes	to
T2667	1501-1506	JJ	denotes	clear
T2668	1507-1514	NNS	denotes	results
T2669	1514-1516	,	denotes	,
T2670	1516-1518	PRP	denotes	we
T2671	1528-1531	PRP$	denotes	our
T2672	1532-1536	NNS	denotes	data
T2673	1537-1545	VBN	denotes	obtained
T2674	1546-1550	IN	denotes	with
T2675	1551-1556	JJ	denotes	human
T2676	1557-1562	NN	denotes	blood
T2677	1562-1563	.	denotes	.
T2678	1563-1780	sentence	denotes	Independent of the presence of annexin A7 both types of exovesicles, micro- and nanovesicles, were released after Ca2+/ionophore treatment as determined by acetylcholine esterase activity and microscopic examination.
T2679	1564-1575	JJ	denotes	Independent
T2680	1663-1671	VBN	denotes	released
T2681	1576-1578	IN	denotes	of
T2682	1579-1582	DT	denotes	the
T2683	1583-1591	NN	denotes	presence
T2684	1592-1594	IN	denotes	of
T2685	1595-1602	NN	denotes	annexin
T2686	1603-1605	NN	denotes	A7
T2687	1606-1610	DT	denotes	both
T2688	1611-1616	NNS	denotes	types
T2689	1617-1619	IN	denotes	of
T2690	1620-1631	NNS	denotes	exovesicles
T2691	1631-1633	,	denotes	,
T2692	1633-1638	AFX	denotes	micro
T2693	1644-1656	NNS	denotes	nanovesicles
T2694	1638-1639	HYPH	denotes	-
T2695	1640-1643	CC	denotes	and
T2696	1656-1658	,	denotes	,
T2697	1658-1662	VBD	denotes	were
T2698	1672-1677	IN	denotes	after
T2699	1678-1682	NN	denotes	Ca2+
T2700	1683-1692	NN	denotes	ionophore
T2701	1682-1683	HYPH	denotes	/
T2702	1693-1702	NN	denotes	treatment
T2703	1703-1705	IN	denotes	as
T2704	1706-1716	VBN	denotes	determined
T2705	1717-1719	IN	denotes	by
T2706	1720-1733	NN	denotes	acetylcholine
T2707	1734-1742	NN	denotes	esterase
T2708	1743-1751	NN	denotes	activity
T2709	1752-1755	CC	denotes	and
T2710	1756-1767	JJ	denotes	microscopic
T2711	1768-1779	NN	denotes	examination
T2712	1779-1780	.	denotes	.
T2713	1780-1876	sentence	denotes	Annexin A7 is present in both vesicle types where it is more enriched in nanovesicles (Fig. 2).
T2714	1781-1788	NN	denotes	Annexin
T2715	1789-1791	NN	denotes	A7
T2716	1792-1794	VBZ	denotes	is
T2717	1795-1802	JJ	denotes	present
T2718	1803-1805	IN	denotes	in
T2719	1806-1810	CC	denotes	both
T2720	1819-1824	NNS	denotes	types
T2721	1811-1818	NN	denotes	vesicle
T2722	1825-1830	WRB	denotes	where
T2723	1834-1836	VBZ	denotes	is
T2724	1831-1833	PRP	denotes	it
T2725	1837-1841	RBR	denotes	more
T2726	1842-1850	JJ	denotes	enriched
T2727	1851-1853	IN	denotes	in
T2728	1854-1866	NNS	denotes	nanovesicles
T2729	1867-1868	-LRB-	denotes	(
T2730	1868-1872	NN	denotes	Fig.
T2731	1873-1874	CD	denotes	2
T2732	1874-1875	-RRB-	denotes	)
T2733	1875-1876	.	denotes	.
T2734	1876-1931	sentence	denotes	The 51 kDa isoform is only detectable in nanovesicles.
T2735	1877-1880	DT	denotes	The
T2736	1888-1895	NN	denotes	isoform
T2737	1881-1883	CD	denotes	51
T2738	1884-1887	NN	denotes	kDa
T2739	1896-1898	VBZ	denotes	is
T2740	1899-1903	RB	denotes	only
T2741	1904-1914	JJ	denotes	detectable
T2742	1915-1917	IN	denotes	in
T2743	1918-1930	NNS	denotes	nanovesicles
T2744	1930-1931	.	denotes	.
T2745	1931-2145	sentence	denotes	The quantity of both vesicle types did not differ between wild type and knock out red blood cell vesicles as determined by the AChE-values (A405 nanovesicles: ~0.18; A405 microvesicles: ~0.9; both, for wt and ko).
T2746	1932-1935	DT	denotes	The
T2747	1936-1944	NN	denotes	quantity
T2748	1975-1981	VB	denotes	differ
T2749	1945-1947	IN	denotes	of
T2750	1948-1952	DT	denotes	both
T2751	1961-1966	NNS	denotes	types
T2752	1953-1960	NN	denotes	vesicle
T2753	1967-1970	VBD	denotes	did
T2754	1971-1974	RB	denotes	not
T2755	1982-1989	IN	denotes	between
T2756	1990-1994	JJ	denotes	wild
T2757	1995-1999	NN	denotes	type
T2758	2029-2037	NNS	denotes	vesicles
T2759	2000-2003	CC	denotes	and
T2760	2004-2009	NN	denotes	knock
T2761	2010-2013	NN	denotes	out
T2762	2014-2017	JJ	denotes	red
T2763	2024-2028	NN	denotes	cell
T2764	2018-2023	NN	denotes	blood
T2765	2038-2040	IN	denotes	as
T2766	2041-2051	VBN	denotes	determined
T2767	2052-2054	IN	denotes	by
T2768	2055-2058	DT	denotes	the
T2769	2064-2070	NNS	denotes	values
T2770	2059-2063	NN	denotes	AChE
T2771	2063-2064	HYPH	denotes	-
T2772	2071-2072	-LRB-	denotes	(
T2773	2124-2128	DT	denotes	both
T2774	2072-2076	NN	denotes	A405
T2775	2077-2089	NNS	denotes	nanovesicles
T2776	2092-2096	CD	denotes	0.18
T2777	2089-2091	:	denotes	:
T2778	2091-2092	SYM	denotes	~
T2779	2096-2097	:	denotes	;
T2780	2098-2102	NN	denotes	A405
T2781	2103-2116	NNS	denotes	microvesicles
T2782	2119-2122	CD	denotes	0.9
T2783	2116-2118	:	denotes	:
T2784	2118-2119	SYM	denotes	~
T2785	2122-2123	:	denotes	;
T2786	2128-2130	,	denotes	,
T2787	2130-2133	IN	denotes	for
T2788	2134-2136	NN	denotes	wt
T2789	2137-2140	CC	denotes	and
T2790	2141-2143	NN	denotes	ko
T2791	2143-2144	-RRB-	denotes	)
T2832	2329-2332	DT	denotes	the
T2833	2333-2341	NN	denotes	presence
T2834	2342-2344	IN	denotes	of
T2835	2345-2351	NN	denotes	sorcin
T2836	2352-2354	IN	denotes	in
T2837	2355-2359	JJ	denotes	wild
T2838	2360-2364	NN	denotes	type
T2839	2376-2384	NNS	denotes	vesicles
T2840	2365-2368	CC	denotes	and
T2841	2369-2375	JJ	denotes	mutant
T2842	2385-2387	PRP	denotes	we
T2843	2394-2398	IN	denotes	that
T2844	2422-2429	VBN	denotes	reduced
T2845	2399-2402	DT	denotes	the
T2846	2410-2416	NNS	denotes	levels
T2847	2403-2409	NN	denotes	sorcin
T2848	2417-2421	VBD	denotes	were
T2849	2430-2432	IN	denotes	in
T2850	2433-2436	DT	denotes	the
T2851	2444-2456	NNS	denotes	nanovesicles
T2852	2437-2443	JJ	denotes	mutant
T2853	2457-2458	-LRB-	denotes	(
T2854	2458-2462	NN	denotes	Fig.
T2855	2463-2464	CD	denotes	2
T2856	2464-2465	-RRB-	denotes	)
T2857	2465-2466	.	denotes	.
T2880	3217-3225	NNS	denotes	isoforms
T2881	3226-3230	VBD	denotes	were
T2882	3231-3238	JJ	denotes	present
T2883	3239-3241	IN	denotes	in
T2884	3242-3245	DT	denotes	the
T2885	3254-3262	NN	denotes	fraction
T2886	3246-3253	JJ	denotes	soluble
T2887	3263-3265	RB	denotes	as
T2888	3271-3273	IN	denotes	as
T2889	3266-3270	RB	denotes	well
T2890	3274-3276	IN	denotes	in
T2891	3277-3280	DT	denotes	the
T2892	3290-3299	NNS	denotes	fractions
T2893	3281-3289	NN	denotes	gradient
T2894	3300-3305	WRB	denotes	where
T2895	3315-3322	VBN	denotes	assumed
T2896	3306-3310	PRP	denotes	they
T2897	3311-3314	VBP	denotes	are
T2898	3323-3325	TO	denotes	to
T2899	3329-3339	VBN	denotes	associated
T2900	3326-3328	VB	denotes	be
T2901	3340-3344	IN	denotes	with
T2902	3345-3354	NNS	denotes	membranes
T2903	3354-3355	.	denotes	.
T2904	3355-3451	sentence	denotes	These membranes are exclusively plasma membranes as red blood cells are free of any organelles.
T2905	3356-3361	DT	denotes	These
T2906	3362-3371	NNS	denotes	membranes
T2907	3372-3375	VBP	denotes	are
T2908	3376-3387	RB	denotes	exclusively
T2909	3388-3394	NN	denotes	plasma
T2910	3395-3404	NNS	denotes	membranes
T2911	3405-3407	IN	denotes	as
T2912	3424-3427	VBP	denotes	are
T2913	3408-3411	JJ	denotes	red
T2914	3418-3423	NNS	denotes	cells
T2915	3412-3417	NN	denotes	blood
T2916	3428-3432	JJ	denotes	free
T2917	3433-3435	IN	denotes	of
T2918	3436-3439	DT	denotes	any
T2919	3440-3450	NNS	denotes	organelles
T2920	3450-3451	.	denotes	.
T2921	3451-3521	sentence	denotes	The distribution was however not homogeneous throughout the gradient.
T2922	3452-3455	DT	denotes	The
T2923	3456-3468	NN	denotes	distribution
T2924	3469-3472	VBD	denotes	was
T2925	3473-3480	RB	denotes	however
T2926	3481-3484	RB	denotes	not
T2927	3485-3496	JJ	denotes	homogeneous
T2928	3497-3507	IN	denotes	throughout
T2929	3508-3511	DT	denotes	the
T2930	3512-3520	NN	denotes	gradient
T2931	3520-3521	.	denotes	.
T2932	3521-3679	sentence	denotes	This could reflect the binding of annexin A7 to membrane subdomains that have different lipid or lipid/protein composition as discussed by Salzer et al. [7].
T2933	3522-3526	DT	denotes	This
T2934	3533-3540	VB	denotes	reflect
T2935	3527-3532	MD	denotes	could
T2936	3541-3544	DT	denotes	the
T2937	3545-3552	NN	denotes	binding
T2938	3553-3555	IN	denotes	of
T2939	3556-3563	NN	denotes	annexin
T2940	3564-3566	NN	denotes	A7
T2941	3567-3569	IN	denotes	to
T2942	3570-3578	NN	denotes	membrane
T2943	3579-3589	NNS	denotes	subdomains
T2944	3590-3594	WDT	denotes	that
T2945	3595-3599	VBP	denotes	have
T2946	3600-3609	JJ	denotes	different
T2947	3633-3644	NN	denotes	composition
T2948	3610-3615	NN	denotes	lipid
T2949	3616-3618	CC	denotes	or
T2950	3619-3624	NN	denotes	lipid
T2951	3625-3632	NN	denotes	protein
T2952	3624-3625	HYPH	denotes	/
T2953	3645-3647	IN	denotes	as
T2954	3648-3657	VBN	denotes	discussed
T2955	3658-3660	IN	denotes	by
T2956	3661-3667	NNP	denotes	Salzer
T2957	3668-3670	FW	denotes	et
T2958	3671-3674	FW	denotes	al.
T2959	3675-3676	-LRB-	denotes	[
T2960	3676-3677	CD	denotes	7
T2961	3677-3678	-RRB-	denotes	]
T2962	3678-3679	.	denotes	.
T2963	3679-3757	sentence	denotes	Likewise, sorcin does not exhibit a homogeneous distribution in the gradient.
T2964	3680-3688	RB	denotes	Likewise
T2965	3706-3713	VB	denotes	exhibit
T2966	3688-3690	,	denotes	,
T2967	3690-3696	NN	denotes	sorcin
T2968	3697-3701	VBZ	denotes	does
T2969	3702-3705	RB	denotes	not
T2970	3714-3715	DT	denotes	a
T2971	3728-3740	NN	denotes	distribution
T2972	3716-3727	JJ	denotes	homogeneous
T2973	3741-3743	IN	denotes	in
T2974	3744-3747	DT	denotes	the
T2975	3748-3756	NN	denotes	gradient
T2976	3756-3757	.	denotes	.
T2977	3757-3846	sentence	denotes	Moreover, it segregates into vesicles which are not associated with annexin A7 (Fig. 3).
T2978	3758-3766	RB	denotes	Moreover
T2979	3771-3781	VBZ	denotes	segregates
T2980	3766-3768	,	denotes	,
T2981	3768-3770	PRP	denotes	it
T2982	3782-3786	IN	denotes	into
T2983	3787-3795	NNS	denotes	vesicles
T2984	3796-3801	WDT	denotes	which
T2985	3810-3820	VBN	denotes	associated
T2986	3802-3805	VBP	denotes	are
T2987	3806-3809	RB	denotes	not
T2988	3821-3825	IN	denotes	with
T2989	3826-3833	NN	denotes	annexin
T2990	3834-3836	NN	denotes	A7
T2991	3837-3838	-LRB-	denotes	(
T2992	3838-3842	NN	denotes	Fig.
T2993	3843-3844	CD	denotes	3
T2994	3844-3845	-RRB-	denotes	)
T2995	3845-3846	.	denotes	.
T2996	3846-3939	sentence	denotes	We also tested platelets for annexin A7 expression and detected the 47 kDa isoform (Fig. 1).
T2997	3847-3849	PRP	denotes	We
T2998	3855-3861	VBD	denotes	tested
T2999	3850-3854	RB	denotes	also
T3000	3862-3871	NNS	denotes	platelets
T3001	3872-3875	IN	denotes	for
T3002	3876-3883	NN	denotes	annexin
T3003	3884-3886	NN	denotes	A7
T3004	3887-3897	NN	denotes	expression
T3005	3898-3901	CC	denotes	and
T3006	3902-3910	VBD	denotes	detected
T3007	3911-3914	DT	denotes	the
T3008	3922-3929	NN	denotes	isoform
T3009	3915-3917	CD	denotes	47
T3010	3918-3921	NN	denotes	kDa
T3011	3930-3931	-LRB-	denotes	(
T3012	3931-3935	NN	denotes	Fig.
T3013	3936-3937	CD	denotes	1
T3014	3937-3938	-RRB-	denotes	)
T3015	3938-3939	.	denotes	.
T3280	4307-4310	DT	denotes	The
T3281	4311-4315	NN	denotes	lack
T3282	4330-4337	VBZ	denotes	changes
T3283	4316-4318	IN	denotes	of
T3284	4319-4326	NN	denotes	annexin
T3285	4327-4329	NN	denotes	A7
T3286	4338-4341	JJ	denotes	red
T3287	4348-4352	NN	denotes	cell
T3288	4342-4347	NN	denotes	blood
T3289	4353-4363	NN	denotes	morphology
T3290	4364-4367	CC	denotes	and
T3291	4368-4375	JJ	denotes	osmotic
T3292	4376-4386	NN	denotes	resistance
T3293	4386-4572	sentence	denotes	As annexin A7 is a component of red blood cell vesicles we studied the consequences of the loss of the protein in the anxA7-/-mouse for red blood cell morphology and osmotic resistance.
T3294	4387-4389	IN	denotes	As
T3295	4401-4403	VBZ	denotes	is
T3296	4390-4397	NN	denotes	annexin
T3297	4398-4400	NN	denotes	A7
T3298	4446-4453	VBD	denotes	studied
T3299	4404-4405	DT	denotes	a
T3300	4406-4415	NN	denotes	component
T3301	4416-4418	IN	denotes	of
T3302	4419-4422	JJ	denotes	red
T3303	4429-4433	NN	denotes	cell
T3304	4423-4428	NN	denotes	blood
T3305	4434-4442	NNS	denotes	vesicles
T3306	4443-4445	PRP	denotes	we
T3307	4454-4457	DT	denotes	the
T3308	4458-4470	NNS	denotes	consequences
T3309	4471-4473	IN	denotes	of
T3310	4474-4477	DT	denotes	the
T3311	4478-4482	NN	denotes	loss
T3312	4483-4485	IN	denotes	of
T3313	4486-4489	DT	denotes	the
T3314	4490-4497	NN	denotes	protein
T3315	4498-4500	IN	denotes	in
T3316	4501-4504	DT	denotes	the
T3317	4513-4518	NN	denotes	mouse
T3318	4505-4510	NN	denotes	anxA7
T3319	4510-4511	SYM	denotes	-
T3320	4511-4512	HYPH	denotes	/
T3321	4512-4513	SYM	denotes	-
T3322	4519-4522	IN	denotes	for
T3323	4523-4526	JJ	denotes	red
T3324	4533-4537	NN	denotes	cell
T3325	4527-4532	NN	denotes	blood
T3326	4538-4548	NN	denotes	morphology
T3327	4549-4552	CC	denotes	and
T3328	4553-4560	JJ	denotes	osmotic
T3329	4561-4571	NN	denotes	resistance
T3330	4571-4572	.	denotes	.
T3331	4572-4745	sentence	denotes	In a standard 'blood smear' we did not note a deformation of the cells, however dark field microscopy revealed changes in shape and diameter of the anxA7-/-red blood cells.
T3332	4573-4575	IN	denotes	In
T3333	4675-4683	VBD	denotes	revealed
T3334	4576-4577	DT	denotes	a
T3335	4594-4599	NN	denotes	smear
T3336	4578-4586	JJ	denotes	standard
T3337	4587-4588	``	denotes	'
T3338	4588-4593	NN	denotes	blood
T3339	4599-4600	''	denotes	'
T3340	4601-4603	PRP	denotes	we
T3341	4612-4616	VB	denotes	note
T3342	4604-4607	VBD	denotes	did
T3343	4608-4611	RB	denotes	not
T3344	4617-4618	DT	denotes	a
T3345	4619-4630	NN	denotes	deformation
T3346	4631-4633	IN	denotes	of
T3347	4634-4637	DT	denotes	the
T3348	4638-4643	NNS	denotes	cells
T3349	4643-4645	,	denotes	,
T3350	4645-4652	RB	denotes	however
T3351	4653-4657	JJ	denotes	dark
T3352	4658-4663	NN	denotes	field
T3353	4664-4674	NN	denotes	microscopy
T3354	4684-4691	NNS	denotes	changes
T3355	4692-4694	IN	denotes	in
T3382	4823-4825	IN	denotes	to
T3383	4826-4830	JJ	denotes	wild
T3384	4831-4835	NN	denotes	type
T3385	4836-4840	IN	denotes	with
T3386	4841-4844	CD	denotes	5.7
T3387	4845-4847	NNS	denotes	μm
T3388	4848-4849	-LRB-	denotes	(
T3389	4864-4866	CD	denotes	40
T3390	4849-4850	NN	denotes	p
T3391	4853-4858	CD	denotes	0.015
T3392	4851-4852	SYM	denotes	=
T3393	4858-4860	,	denotes	,
T3394	4860-4861	NN	denotes	n
T3395	4862-4863	SYM	denotes	=
T3396	4866-4867	-RRB-	denotes	)
T3397	4867-4869	,	denotes	,
T3398	4869-4870	DT	denotes	a
T3399	4907-4917	NN	denotes	impression
T3400	4871-4881	RB	denotes	remarkably
T3401	4882-4887	JJR	denotes	lower
T3402	4888-4898	VBN	denotes	emphasized
T3403	4899-4906	JJ	denotes	central
T3404	4918-4921	CC	denotes	and
T3405	4922-4923	DT	denotes	a
T3406	4934-4939	NN	denotes	shape
T3407	4924-4928	RBR	denotes	more
T3408	4929-4933	JJ	denotes	flat
T3409	4940-4941	-LRB-	denotes	(
T3410	4941-4945	NN	denotes	Fig.
T3411	4946-4947	CD	denotes	4
T3412	4947-4948	-RRB-	denotes	)
T3413	4948-4949	.	denotes	.
T3414	4949-5054	sentence	denotes	No significant change in the mean corpuscular volume (MCV) was measured with the ADVIA 120 cell counter.
T3415	4950-4952	DT	denotes	No
T3416	4965-4971	NN	denotes	change
T3417	4953-4964	JJ	denotes	significant
T3418	5013-5021	VBN	denotes	measured
T3419	4972-4974	IN	denotes	in
T3420	4975-4978	DT	denotes	the
T3421	4996-5002	NN	denotes	volume
T3422	4979-4983	JJ	denotes	mean
T3423	4984-4995	JJ	denotes	corpuscular
T3424	5003-5004	-LRB-	denotes	(
T3425	5004-5007	NN	denotes	MCV
T3426	5007-5008	-RRB-	denotes	)
T3427	5009-5012	VBD	denotes	was
T3428	5022-5026	IN	denotes	with
T3429	5027-5030	DT	denotes	the
T3430	5046-5053	NN	denotes	counter
T3431	5031-5036	NN	denotes	ADVIA
T3432	5037-5040	CD	denotes	120
T3433	5041-5045	NN	denotes	cell
T3434	5053-5054	.	denotes	.
T3435	5054-5055	sentence	denotes
T3475	5556-5560	VB	denotes	play
T3476	5539-5546	NN	denotes	annexin
T3477	5547-5549	NN	denotes	A7
T3478	5550-5555	MD	denotes	might
T3479	5561-5562	DT	denotes	a
T3480	5563-5567	NN	denotes	role
T3481	5567-5568	.	denotes	.
T3482	5568-5737	sentence	denotes	The osmotic resistance, which is the resistance towards changes in the extracellular ionic strength, is a convenient assay for analysis of the red blood cell integrity.
T3483	5569-5572	DT	denotes	The
T3484	5581-5591	NN	denotes	resistance
T3485	5573-5580	JJ	denotes	osmotic
T3486	5670-5672	VBZ	denotes	is
T3487	5591-5593	,	denotes	,
T3488	5593-5598	WDT	denotes	which
T3489	5599-5601	VBZ	denotes	is
T3490	5602-5605	DT	denotes	the
T3491	5606-5616	NN	denotes	resistance
T3492	5617-5624	IN	denotes	towards
T3493	5625-5632	NNS	denotes	changes
T3494	5633-5635	IN	denotes	in
T3495	5636-5639	DT	denotes	the
T3496	5660-5668	NN	denotes	strength
T3497	5640-5653	JJ	denotes	extracellular
T3498	5654-5659	JJ	denotes	ionic
T3499	5668-5670	,	denotes	,
T3500	5673-5674	DT	denotes	a
T3501	5686-5691	NN	denotes	assay
T3502	5675-5685	JJ	denotes	convenient
T3503	5692-5695	IN	denotes	for
T3504	5696-5704	NN	denotes	analysis
T3505	5705-5707	IN	denotes	of
T3506	5708-5711	DT	denotes	the
T3507	5727-5736	NN	denotes	integrity
T3508	5712-5715	JJ	denotes	red
T3509	5722-5726	NN	denotes	cell
T3510	5716-5721	NN	denotes	blood
T3511	5736-5737	.	denotes	.
T3512	5737-5904	sentence	denotes	It is measured as the sodium chloride concentration at which cellular lysis starts (minimal resistance) up to a complete lysis (maximal resistance) of the cells [33].
T3513	5738-5740	PRP	denotes	It
T3514	5744-5752	VBN	denotes	measured
T3515	5741-5743	VBZ	denotes	is
T3516	5753-5755	IN	denotes	as
T3517	5756-5759	DT	denotes	the
T3518	5776-5789	NN	denotes	concentration
T3519	5760-5766	NN	denotes	sodium
T3520	5767-5775	NN	denotes	chloride
T3521	5790-5792	IN	denotes	at
T3522	5814-5820	VBZ	denotes	starts
T3523	5793-5798	WDT	denotes	which
T3524	5799-5807	JJ	denotes	cellular
T3525	5808-5813	NN	denotes	lysis
T3526	5821-5822	-LRB-	denotes	(
T3527	5822-5829	JJ	denotes	minimal
T3528	5830-5840	NN	denotes	resistance
T3529	5840-5841	-RRB-	denotes	)
T3530	5842-5844	IN	denotes	up
T3531	5845-5847	IN	denotes	to
T3532	5848-5849	DT	denotes	a
T3533	5859-5864	NN	denotes	lysis
T3534	5850-5858	JJ	denotes	complete
T3535	5865-5866	-LRB-	denotes	(
T3536	5866-5873	JJ	denotes	maximal
T3537	5874-5884	NN	denotes	resistance
T3538	5884-5885	-RRB-	denotes	)
T3539	5886-5888	IN	denotes	of
T3540	5889-5892	DT	denotes	the
T3541	5893-5898	NNS	denotes	cells
T3542	5899-5900	-LRB-	denotes	[
T3543	5900-5902	CD	denotes	33
T3544	5902-5903	-RRB-	denotes	]
T3545	5903-5904	.	denotes	.
T3546	5904-6055	sentence	denotes	Osmotic resistance increases with higher MCV, larger surface area and a higher degree of cellular metabolism stabilizing the intracellular ion levels.
T3547	5905-5912	JJ	denotes	Osmotic
T3548	5913-5923	NN	denotes	resistance
T3549	5924-5933	VBZ	denotes	increases
T3550	5934-5938	IN	denotes	with
T3551	5939-5945	JJR	denotes	higher
T3552	5946-5949	NN	denotes	MCV
T3553	5949-5951	,	denotes	,
T3554	5951-5957	JJR	denotes	larger
T3555	5966-5970	NN	denotes	area
T3556	5958-5965	NN	denotes	surface
T3557	5971-5974	CC	denotes	and
T3558	5975-5976	DT	denotes	a
T3559	5984-5990	NN	denotes	degree
T3560	5977-5983	JJR	denotes	higher
T3561	5991-5993	IN	denotes	of
T3562	5994-6002	JJ	denotes	cellular
T3563	6003-6013	NN	denotes	metabolism
T3564	6014-6025	VBG	denotes	stabilizing
T3565	6026-6029	DT	denotes	the
T3566	6048-6054	NNS	denotes	levels
T3567	6030-6043	JJ	denotes	intracellular
T3568	6044-6047	NN	denotes	ion
T3569	6054-6055	.	denotes	.
T3570	6055-6130	sentence	denotes	Aged red blood cells show a lowered MCV and lower osmotic resistance [33].
T3571	6056-6060	VBN	denotes	Aged
T3572	6071-6076	NNS	denotes	cells
T3573	6061-6064	JJ	denotes	red
T3574	6065-6070	NN	denotes	blood
T3575	6077-6081	VBP	denotes	show
T3576	6082-6083	DT	denotes	a
T3577	6092-6095	NN	denotes	MCV
T3578	6084-6091	JJ	denotes	lowered
T3579	6096-6099	CC	denotes	and
T3580	6100-6105	JJR	denotes	lower
T3581	6114-6124	NN	denotes	resistance
T3582	6106-6113	JJ	denotes	osmotic
T3583	6125-6126	-LRB-	denotes	[
T3584	6126-6128	CD	denotes	33
T3585	6128-6129	-RRB-	denotes	]
T3586	6129-6130	.	denotes	.
T3587	6130-6220	sentence	denotes	Similar properties can be observed in red blood cells with lowered membrane permeability.
T3588	6131-6138	JJ	denotes	Similar
T3589	6139-6149	NNS	denotes	properties
T3590	6157-6165	VBN	denotes	observed
T3591	6150-6153	MD	denotes	can
T3592	6154-6156	VB	denotes	be
T3593	6166-6168	IN	denotes	in
T3594	6169-6172	JJ	denotes	red
T3595	6179-6184	NNS	denotes	cells
T3596	6173-6178	NN	denotes	blood
T3597	6185-6189	IN	denotes	with
T3598	6190-6197	VBN	denotes	lowered
T3599	6207-6219	NN	denotes	permeability
T3600	6198-6206	NN	denotes	membrane
T3601	6219-6220	.	denotes	.
T3602	6220-6339	sentence	denotes	The osmotic resistance of annexin A7 deficient red blood cells is significantly increased compared to wild type cells.
T3603	6221-6224	DT	denotes	The
T3604	6233-6243	NN	denotes	resistance
T3605	6225-6232	JJ	denotes	osmotic
T3606	6284-6286	VBZ	denotes	is
T3607	6244-6246	IN	denotes	of
T3608	6247-6254	NN	denotes	annexin
T3609	6255-6257	NN	denotes	A7
T3610	6258-6267	JJ	denotes	deficient
T3611	6278-6283	NNS	denotes	cells
T3612	6268-6271	JJ	denotes	red
T3613	6272-6277	NN	denotes	blood
T3614	6287-6300	RB	denotes	significantly
T3615	6301-6310	VBN	denotes	increased
T3616	6311-6319	VBN	denotes	compared
T3617	6320-6322	IN	denotes	to
T3618	6323-6327	JJ	denotes	wild
T3619	6328-6332	NN	denotes	type
T3620	6333-6338	NNS	denotes	cells
T3621	6338-6339	.	denotes	.
T3622	6339-6460	sentence	denotes	The minimal resistance value of knock out cells is observed in a 0.60 % NaCl solution versus 0.65 % for wild type cells.
T3623	6340-6343	DT	denotes	The
T3624	6363-6368	NN	denotes	value
T3625	6344-6351	JJ	denotes	minimal
T3626	6352-6362	NN	denotes	resistance
T3627	6391-6399	VBN	denotes	observed
T3628	6369-6371	IN	denotes	of
T3629	6372-6377	NN	denotes	knock
T3630	6378-6381	NN	denotes	out
T3631	6382-6387	NNS	denotes	cells
T3632	6388-6390	VBZ	denotes	is
T3633	6400-6402	IN	denotes	in
T3634	6403-6404	DT	denotes	a
T3635	6417-6425	NN	denotes	solution
T3636	6405-6409	CD	denotes	0.60
T3637	6410-6411	NN	denotes	%
T3638	6412-6416	NN	denotes	NaCl
T3639	6426-6432	CC	denotes	versus
T3640	6433-6437	CD	denotes	0.65
T3641	6438-6439	NN	denotes	%
T3642	6440-6443	IN	denotes	for
T3643	6444-6448	JJ	denotes	wild
T3644	6449-6453	NN	denotes	type
T3645	6454-6459	NNS	denotes	cells
T3646	6459-6460	.	denotes	.
T3647	6460-6610	sentence	denotes	50 % haemolysis is achieved at 0.516 % NaCl solution for knock out versus 0.564 % NaCl for wild type cells (mean values, p = 0.00066, n = 8; Fig. 5).
T3648	6461-6463	CD	denotes	50
T3649	6464-6465	NN	denotes	%
T3650	6466-6476	NN	denotes	haemolysis
T3651	6480-6488	VBN	denotes	achieved
T3652	6477-6479	VBZ	denotes	is
T3653	6489-6491	IN	denotes	at
T3654	6492-6497	CD	denotes	0.516
T3655	6498-6499	NN	denotes	%
T3656	6505-6513	NN	denotes	solution
T3657	6500-6504	NN	denotes	NaCl
T3658	6514-6517	IN	denotes	for
T3659	6518-6523	NN	denotes	knock
T3660	6524-6527	NN	denotes	out
T3661	6528-6534	CC	denotes	versus
T3662	6535-6540	CD	denotes	0.564
T3663	6541-6542	NN	denotes	%
T3664	6543-6547	NN	denotes	NaCl
T3665	6548-6551	IN	denotes	for
T3666	6552-6556	JJ	denotes	wild
T3667	6557-6561	NN	denotes	type
T3668	6562-6567	NNS	denotes	cells
T3669	6568-6569	-LRB-	denotes	(
T3670	6602-6606	NN	denotes	Fig.
T3671	6569-6573	NN	denotes	mean
T3672	6574-6580	NNS	denotes	values
T3673	6580-6582	,	denotes	,
T3674	6582-6583	NN	denotes	p
T3675	6586-6593	CD	denotes	0.00066
T3676	6584-6585	SYM	denotes	=
T3677	6593-6595	,	denotes	,
T3678	6595-6596	NN	denotes	n
T3679	6599-6600	CD	denotes	8
T3680	6597-6598	SYM	denotes	=
T3681	6600-6601	:	denotes	;
T3682	6607-6608	CD	denotes	5
T3683	6608-6609	-RRB-	denotes	)
T3684	6609-6610	.	denotes	.
T3685	6610-6714	sentence	denotes	The resistance width of the knock out cells is slightly lower (0.20 % instead of 0.25 % NaCl solution).
T3686	6611-6614	DT	denotes	The
T3687	6626-6631	NN	denotes	width
T3688	6615-6625	NN	denotes	resistance
T3689	6655-6657	VBZ	denotes	is
T3690	6632-6634	IN	denotes	of
T3691	6635-6638	DT	denotes	the
T3692	6649-6654	NNS	denotes	cells
T3693	6639-6644	NN	denotes	knock
T3694	6645-6648	NN	denotes	out
T3695	6658-6666	RB	denotes	slightly
T3696	6667-6672	JJR	denotes	lower
T3697	6673-6674	-LRB-	denotes	(
T3698	6704-6712	NN	denotes	solution
T3699	6674-6678	CD	denotes	0.20
T3700	6679-6680	NN	denotes	%
T3701	6699-6703	NN	denotes	NaCl
T3702	6681-6688	RB	denotes	instead
T3703	6689-6691	IN	denotes	of
T3704	6692-6696	CD	denotes	0.25
T3705	6697-6698	NN	denotes	%
T3706	6712-6713	-RRB-	denotes	)
T3707	6713-6714	.	denotes	.
T3708	6714-6879	sentence	denotes	We also performed direct measurements of the red blood cell membrane deformability, to further characterize a possible role of annexin A7 on the membrane stability.
T3709	6715-6717	PRP	denotes	We
T3710	6723-6732	VBD	denotes	performed
T3711	6718-6722	RB	denotes	also
T3712	6733-6739	JJ	denotes	direct
T3713	6740-6752	NNS	denotes	measurements
T3714	6753-6755	IN	denotes	of
T3718	6770-6774	NN	denotes	cell
T3719	6764-6769	NN	denotes	blood
T3720	6775-6783	NN	denotes	membrane
T3721	6797-6799	,	denotes	,
T3722	6799-6801	TO	denotes	to
T3723	6810-6822	VB	denotes	characterize
T3724	6802-6809	RBR	denotes	further
T3725	6823-6824	DT	denotes	a
T3726	6834-6838	NN	denotes	role
T3727	6825-6833	JJ	denotes	possible
T3728	6839-6841	IN	denotes	of
T3729	6842-6849	NN	denotes	annexin
T3730	6850-6852	NN	denotes	A7
T3731	6853-6855	IN	denotes	on
T3732	6856-6859	DT	denotes	the
T3733	6869-6878	NN	denotes	stability
T3734	6860-6868	NN	denotes	membrane
T3735	6878-6879	.	denotes	.
T3736	6879-7004	sentence	denotes	With micropipette experiments we tried to correlate mechanical characteristics of the red blood cells with their morphology.
T3737	6880-6884	IN	denotes	With
T3738	6913-6918	VBD	denotes	tried
T3739	6885-6897	NN	denotes	micropipette
T3740	6898-6909	NNS	denotes	experiments
T3741	6910-6912	PRP	denotes	we
T3742	6919-6921	TO	denotes	to
T3743	6922-6931	VB	denotes	correlate
T3744	6932-6942	JJ	denotes	mechanical
T3745	6943-6958	NNS	denotes	characteristics
T3746	6959-6961	IN	denotes	of
T3747	6962-6965	DT	denotes	the
T3748	6976-6981	NNS	denotes	cells
T3749	6966-6969	JJ	denotes	red
T3750	6970-6975	NN	denotes	blood
T3751	6982-6986	IN	denotes	with
T3752	6987-6992	PRP$	denotes	their
T3753	6993-7003	NN	denotes	morphology
T3754	7003-7004	.	denotes	.
T3755	7004-7201	sentence	denotes	We could not observe any statistically significant difference of values describing membrane rigidity and lysis force in these experiments (M. Heil, B. Hoffmann and R. Merkel, unpublished results).
T3756	7005-7007	PRP	denotes	We
T3757	7018-7025	VB	denotes	observe
T3758	7008-7013	MD	denotes	could
T3759	7014-7017	RB	denotes	not
T3760	7026-7029	DT	denotes	any
T3761	7056-7066	NN	denotes	difference
T3762	7030-7043	RB	denotes	statistically
T3763	7044-7055	JJ	denotes	significant
T3764	7067-7069	IN	denotes	of
T3765	7070-7076	NNS	denotes	values
T3766	7077-7087	VBG	denotes	describing
T3767	7088-7096	NN	denotes	membrane
T3768	7097-7105	NN	denotes	rigidity
T3769	7106-7109	CC	denotes	and
T3770	7110-7115	NN	denotes	lysis
T3771	7116-7121	NN	denotes	force
T3772	7122-7124	IN	denotes	in
T3773	7125-7130	DT	denotes	these
T3774	7131-7142	NNS	denotes	experiments
T3775	7143-7144	-LRB-	denotes	(
T3776	7144-7146	NNP	denotes	M.
T3777	7147-7151	NNP	denotes	Heil
T3778	7151-7153	,	denotes	,
T3779	7153-7155	NNP	denotes	B.
T3780	7156-7164	NNP	denotes	Hoffmann
T3781	7165-7168	CC	denotes	and
T3782	7169-7171	NNP	denotes	R.
T3783	7172-7178	NNP	denotes	Merkel
T3784	7178-7180	,	denotes	,
T3785	7180-7191	JJ	denotes	unpublished
T3786	7192-7199	NNS	denotes	results
T3787	7199-7200	-RRB-	denotes	)
T3788	7200-7201	.	denotes	.
T3789	7201-7371	sentence	denotes	However, the distinction observed in the osmotic resistance experiments was highly significant and reflects a mean value over a high number of different red blood cells.
T3790	7202-7209	RB	denotes	However
T3791	7274-7277	VBD	denotes	was
T3792	7209-7211	,	denotes	,
T3793	7211-7214	DT	denotes	the
T3794	7215-7226	NN	denotes	distinction
T3795	7227-7235	VBN	denotes	observed
T3796	7236-7238	IN	denotes	in
T3797	7239-7242	DT	denotes	the
T3798	7262-7273	NNS	denotes	experiments
T3799	7243-7250	JJ	denotes	osmotic
T3800	7251-7261	NN	denotes	resistance
T3801	7278-7284	RB	denotes	highly
T3802	7285-7296	JJ	denotes	significant
T3803	7297-7300	CC	denotes	and
T3804	7301-7309	VBZ	denotes	reflects
T3805	7310-7311	DT	denotes	a
T3806	7317-7322	NN	denotes	value
T3807	7312-7316	JJ	denotes	mean
T3808	7323-7327	IN	denotes	over
T3809	7328-7329	DT	denotes	a
T3810	7335-7341	NN	denotes	number
T3811	7330-7334	JJ	denotes	high
T3812	7342-7344	IN	denotes	of
T3813	7345-7354	JJ	denotes	different
T3814	7365-7370	NNS	denotes	cells
T3815	7355-7358	JJ	denotes	red
T3816	7359-7364	NN	denotes	blood
T3817	7370-7371	.	denotes	.
T3818	7371-8029	sentence	denotes	Figure 5 Osmotic resistance curves of red blood cells from wild type and anxA7-/- mutant mice. The osmotic resistance towards changes in the extracellular ionic strength is a convenient assay for analysis of the red blood cell integrity. It is measured as a sodium chloride concentration in which cellular lysis starts (minimal resistance) up to a complete lysis (maximal resistance) of a red blood cell. The osmotic resistance of annexin A7 deficient red blood cells is significantly increased compared to the one of wild type (p = 0.00066; n = 8). These data suggest that annexin A7 contributes to the shape of red blood cells and the osmotic resistance.
T3819	7923-7928	DT	denotes	These
T3820	7929-7933	NNS	denotes	data
T3821	7934-7941	VBP	denotes	suggest
T3822	7942-7946	IN	denotes	that
T3823	7958-7969	VBZ	denotes	contributes
T3824	7947-7954	NN	denotes	annexin
T3825	7955-7957	NN	denotes	A7
T3826	7970-7972	IN	denotes	to
T3827	7973-7976	DT	denotes	the
T3828	7977-7982	NN	denotes	shape
T3829	7983-7985	IN	denotes	of
T3830	7986-7989	JJ	denotes	red
T3831	7996-8001	NNS	denotes	cells
T3832	7990-7995	NN	denotes	blood
T3833	8002-8005	CC	denotes	and
T3834	8006-8009	DT	denotes	the
T3835	8018-8028	NN	denotes	resistance
T3836	8010-8017	JJ	denotes	osmotic
T3837	8028-8029	.	denotes	.
T3838	8029-8207	sentence	denotes	As we have not observed a binding of annexin A7 to F-actin (data not shown) it could do so either by alteration of the membrane rigidity and/or by affecting the ion homeostasis.
T3839	8030-8032	IN	denotes	As
T3840	8045-8053	VBN	denotes	observed
T3841	8033-8035	PRP	denotes	we
T3842	8036-8040	VBP	denotes	have
T3843	8041-8044	RB	denotes	not
T3844	8115-8117	VB	denotes	do
T3845	8054-8055	DT	denotes	a
T3846	8056-8063	NN	denotes	binding
T3847	8064-8066	IN	denotes	of
T3848	8067-8074	NN	denotes	annexin
T3849	8075-8077	NN	denotes	A7
T3850	8078-8080	IN	denotes	to
T3851	8081-8082	NN	denotes	F
T3852	8083-8088	NN	denotes	actin
T3853	8082-8083	HYPH	denotes	-
T3854	8089-8090	-LRB-	denotes	(
T3855	8099-8104	VBN	denotes	shown
T3856	8090-8094	NNS	denotes	data
T3857	8095-8098	RB	denotes	not
T3858	8104-8105	-RRB-	denotes	)
T3859	8106-8108	PRP	denotes	it
T3860	8109-8114	MD	denotes	could
T3861	8118-8120	RB	denotes	so
T3862	8121-8127	CC	denotes	either
T3863	8128-8130	IN	denotes	by
T3864	8131-8141	NN	denotes	alteration
T3865	8142-8144	IN	denotes	of
T3866	8145-8148	DT	denotes	the
T3867	8158-8166	NN	denotes	rigidity
T3868	8149-8157	NN	denotes	membrane
T3869	8167-8170	CC	denotes	and
T3870	8170-8171	HYPH	denotes	/
T3871	8171-8173	CC	denotes	or
T3872	8174-8176	IN	denotes	by
T3873	8177-8186	VBG	denotes	affecting
T3874	8187-8190	DT	denotes	the
T3875	8195-8206	NN	denotes	homeostasis
T3876	8191-8194	NN	denotes	ion
T3877	8206-8207	.	denotes	.
T4078	8209-8212	DT	denotes	The
T4079	8213-8217	NN	denotes	lack
T4080	8232-8239	VBZ	denotes	affects
T4081	8218-8220	IN	denotes	of
T4082	8221-8228	NN	denotes	annexin
T4083	8229-8231	NN	denotes	A7
T4084	8240-8247	JJ	denotes	primary
T4085	8248-8259	NN	denotes	haemostasis
T4086	8260-8262	FW	denotes	ex
T4087	8263-8267	FW	denotes	vivo
T4088	8267-8431	sentence	denotes	The use of an advanced electronic cell counter/flow cytometer (ADVIA 120) allowed us to screen other parameters as well despite of the limited murine blood volume.
T4089	8268-8271	DT	denotes	The
T4090	8272-8275	NN	denotes	use
T4091	8342-8349	VBD	denotes	allowed
T4092	8276-8278	IN	denotes	of
T4093	8279-8281	DT	denotes	an
T4094	8307-8314	NN	denotes	counter
T4095	8282-8290	JJ	denotes	advanced
T4096	8291-8301	JJ	denotes	electronic
T4097	8302-8306	NN	denotes	cell
T4098	8314-8315	HYPH	denotes	/
T4099	8315-8319	NN	denotes	flow
T4100	8320-8329	NN	denotes	cytometer
T4101	8330-8331	-LRB-	denotes	(
T4102	8331-8336	NN	denotes	ADVIA
T4103	8337-8340	CD	denotes	120
T4104	8340-8341	-RRB-	denotes	)
T4105	8350-8352	PRP	denotes	us
T4106	8356-8362	VB	denotes	screen
T4107	8353-8355	TO	denotes	to
T4108	8363-8368	JJ	denotes	other
T4109	8369-8379	NNS	denotes	parameters
T4110	8380-8382	RB	denotes	as
T4111	8383-8387	RB	denotes	well
T4112	8388-8395	IN	denotes	despite
T4113	8396-8398	IN	denotes	of
T4114	8399-8402	DT	denotes	the
T4115	8424-8430	NN	denotes	volume
T4116	8403-8410	JJ	denotes	limited
T4117	8411-8417	JJ	denotes	murine
T4118	8418-8423	NN	denotes	blood
T4119	8430-8431	.	denotes	.
T4120	8431-8674	sentence	denotes	We analysed leukocytes, red blood cells, haemoglobin content, haematocrit, mean cellular volume, mean cellular haemoglobin, mean cellular haemoglobin concentration, platelets, neutrophiles, lymphocytes, monocytes, eosinophiles and basophiles.
T4121	8432-8434	PRP	denotes	We
T4122	8435-8443	VBD	denotes	analysed
T4123	8444-8454	NNS	denotes	leukocytes
T4124	8454-8456	,	denotes	,
T4125	8456-8459	JJ	denotes	red
T4126	8466-8471	NNS	denotes	cells
T4127	8460-8465	NN	denotes	blood
T4128	8471-8473	,	denotes	,
T4129	8473-8484	NN	denotes	haemoglobin
T4130	8485-8492	NN	denotes	content
T4131	8492-8494	,	denotes	,
T4132	8494-8505	NN	denotes	haematocrit
T4133	8505-8507	,	denotes	,
T4134	8507-8511	JJ	denotes	mean
T4135	8521-8527	NN	denotes	volume
T4136	8512-8520	JJ	denotes	cellular
T4137	8527-8529	,	denotes	,
T4138	8529-8533	JJ	denotes	mean
T4139	8543-8554	NN	denotes	haemoglobin
T4140	8534-8542	JJ	denotes	cellular
T4141	8554-8556	,	denotes	,
T4142	8556-8560	JJ	denotes	mean
T4143	8570-8581	NN	denotes	haemoglobin
T4144	8561-8569	JJ	denotes	cellular
T4145	8582-8595	NN	denotes	concentration
T4146	8595-8597	,	denotes	,
T4147	8597-8606	NNS	denotes	platelets
T4148	8606-8608	,	denotes	,
T4149	8608-8620	NNS	denotes	neutrophiles
T4150	8620-8622	,	denotes	,
T4151	8622-8633	NNS	denotes	lymphocytes
T4152	8633-8635	,	denotes	,
T4153	8635-8644	NNS	denotes	monocytes
T4154	8644-8646	,	denotes	,
T4155	8646-8658	NNS	denotes	eosinophiles
T4156	8659-8662	CC	denotes	and
T4157	8663-8673	NNS	denotes	basophiles
T4158	8673-8674	.	denotes	.
T4159	8674-8815	sentence	denotes	In these tests of whole blood we found only a change in the platelet numbers, whereas all other haematological parameters were not affected.
T4160	8675-8677	IN	denotes	In
T4161	8708-8713	VBD	denotes	found
T4162	8678-8683	DT	denotes	these
T4163	8684-8689	NNS	denotes	tests
T4164	8690-8692	IN	denotes	of
T4165	8693-8698	JJ	denotes	whole
T4166	8699-8704	NN	denotes	blood
T4167	8705-8707	PRP	denotes	we
T4168	8714-8718	RB	denotes	only
T4169	8719-8720	DT	denotes	a
T4170	8721-8727	NN	denotes	change
T4171	8728-8730	IN	denotes	in
T4172	8731-8734	DT	denotes	the
T4173	8744-8751	NNS	denotes	numbers
T4174	8735-8743	NN	denotes	platelet
T4175	8751-8753	,	denotes	,
T4176	8753-8760	IN	denotes	whereas
T4177	8806-8814	VBN	denotes	affected
T4178	8761-8764	DT	denotes	all
T4179	8786-8796	NNS	denotes	parameters
T4180	8765-8770	JJ	denotes	other
T4181	8771-8785	JJ	denotes	haematological
T4182	8797-8801	VBD	denotes	were
T4183	8802-8805	RB	denotes	not
T4184	8814-8815	.	denotes	.
T4185	8815-8943	sentence	denotes	The mean platelet counts from wild type and anxA7-/- mutant mice are determined as 674 × 103/μl and 774 × 103/μl, respectively.
T4186	8816-8819	DT	denotes	The
T4187	8834-8840	NNS	denotes	counts
T4188	8820-8824	JJ	denotes	mean
T4189	8825-8833	NN	denotes	platelet
T4190	8885-8895	VBN	denotes	determined
T4191	8841-8845	IN	denotes	from
T4192	8846-8850	JJ	denotes	wild
T4193	8851-8855	NN	denotes	type
T4194	8876-8880	NNS	denotes	mice
T4195	8856-8859	CC	denotes	and
T4196	8860-8865	NN	denotes	anxA7
T4197	8865-8866	SYM	denotes	-
T4198	8866-8867	HYPH	denotes	/
T4199	8867-8868	SYM	denotes	-
T4200	8869-8875	JJ	denotes	mutant
T4201	8881-8884	VBP	denotes	are
T4202	8896-8898	IN	denotes	as
T4203	8899-8902	CD	denotes	674
T4204	8905-8908	CD	denotes	103
T4205	8903-8904	SYM	denotes	×
T4206	8908-8909	SYM	denotes	/
T4207	8909-8911	NNS	denotes	μl
T4208	8912-8915	CC	denotes	and
T4209	8916-8919	CD	denotes	774
T4210	8922-8925	CD	denotes	103
T4211	8920-8921	SYM	denotes	×
T4212	8925-8926	SYM	denotes	/
T4213	8926-8928	NNS	denotes	μl
T4214	8928-8930	,	denotes	,
T4215	8930-8942	RB	denotes	respectively
T4216	8942-8943	.	denotes	.
T4217	8943-9056	sentence	denotes	The platelet counts in knock out mice are significantly higher (p = 0.0275; n knock out = 11, n wild type = 14).
T4218	8944-8947	DT	denotes	The
T4219	8957-8963	NNS	denotes	counts
T4220	8948-8956	NN	denotes	platelet
T4221	8982-8985	VBP	denotes	are
T4222	8964-8966	IN	denotes	in
T4223	8967-8972	NN	denotes	knock
T4224	8973-8976	NN	denotes	out
T4225	8977-8981	NNS	denotes	mice
T4226	8986-8999	RB	denotes	significantly
T4227	9000-9006	JJR	denotes	higher
T4228	9007-9008	-LRB-	denotes	(
T4229	9052-9054	CD	denotes	14
T4230	9008-9009	NN	denotes	p
T4231	9012-9018	CD	denotes	0.0275
T4232	9010-9011	SYM	denotes	=
T4233	9018-9019	:	denotes	;
T4234	9020-9021	NN	denotes	n
T4235	9028-9031	NN	denotes	out
T4236	9022-9027	NN	denotes	knock
T4237	9034-9036	CD	denotes	11
T4238	9032-9033	SYM	denotes	=
T4239	9036-9038	,	denotes	,
T4240	9038-9039	NN	denotes	n
T4241	9045-9049	NN	denotes	type
T4242	9040-9044	JJ	denotes	wild
T4243	9050-9051	SYM	denotes	=
T4244	9054-9055	-RRB-	denotes	)
T4245	9055-9056	.	denotes	.
T4246	9056-9118	sentence	denotes	An increase in platelet counts is a rather uncommon disorder.
T4247	9057-9059	DT	denotes	An
T4248	9060-9068	NN	denotes	increase
T4249	9088-9090	VBZ	denotes	is
T4250	9069-9071	IN	denotes	in
T4251	9072-9080	NN	denotes	platelet
T4252	9081-9087	NNS	denotes	counts
T4253	9091-9092	DT	denotes	a
T4254	9109-9117	NN	denotes	disorder
T4255	9093-9099	RB	denotes	rather
T4256	9100-9108	JJ	denotes	uncommon
T4257	9117-9118	.	denotes	.
T4258	9118-9294	sentence	denotes	In humans, platelet counts normally increase only transiently as in reactive thrombocytosis and under postoperative conditions or are largely increased in neoplastic diseases.
T4259	9119-9121	IN	denotes	In
T4260	9155-9163	VBP	denotes	increase
T4261	9122-9128	NNS	denotes	humans
T4262	9128-9130	,	denotes	,
T4263	9130-9138	NN	denotes	platelet
T4264	9139-9145	NNS	denotes	counts
T4265	9146-9154	RB	denotes	normally
T4266	9164-9168	RB	denotes	only
T4267	9169-9180	RB	denotes	transiently
T4268	9181-9183	IN	denotes	as
T4269	9184-9186	IN	denotes	in
T4270	9187-9195	JJ	denotes	reactive
T4271	9196-9210	NN	denotes	thrombocytosis
T4272	9211-9214	CC	denotes	and
T4273	9215-9220	IN	denotes	under
T4274	9221-9234	JJ	denotes	postoperative
T4275	9235-9245	NNS	denotes	conditions
T4276	9246-9248	CC	denotes	or
T4277	9249-9252	VBP	denotes	are
T4278	9261-9270	VBN	denotes	increased
T4279	9253-9260	RB	denotes	largely
T4280	9271-9273	IN	denotes	in
T4281	9274-9284	JJ	denotes	neoplastic
T4282	9285-9293	NNS	denotes	diseases
T4283	9293-9294	.	denotes	.
T4284	9294-9348	sentence	denotes	By contrast, the anxA7-/-mice are healthy and viable.
T4285	9295-9297	IN	denotes	By
T4286	9325-9328	VBP	denotes	are
T4287	9298-9306	NN	denotes	contrast
T4288	9306-9308	,	denotes	,
T4289	9308-9311	DT	denotes	the
T4290	9320-9324	NNS	denotes	mice
T4291	9312-9317	NN	denotes	anxA7
T4292	9317-9318	SYM	denotes	-
T4293	9318-9319	HYPH	denotes	/
T4294	9319-9320	SYM	denotes	-
T4295	9329-9336	JJ	denotes	healthy
T4296	9337-9340	CC	denotes	and
T4297	9341-9347	JJ	denotes	viable
T4298	9347-9348	.	denotes	.
T4299	9348-9457	sentence	denotes	Therefore we tested the platelet function and performed aggregometry measurements with platelet rich plasma.
T4300	9349-9358	RB	denotes	Therefore
T4301	9362-9368	VBD	denotes	tested
T4302	9359-9361	PRP	denotes	we
T4303	9369-9372	DT	denotes	the
T4304	9382-9390	NN	denotes	function
T4305	9373-9381	NN	denotes	platelet
T4306	9391-9394	CC	denotes	and
T4307	9395-9404	VBD	denotes	performed
T4308	9405-9417	NN	denotes	aggregometry
T4309	9418-9430	NNS	denotes	measurements
T4310	9431-9435	IN	denotes	with
T4311	9436-9444	NN	denotes	platelet
T4312	9445-9449	JJ	denotes	rich
T4313	9450-9456	NN	denotes	plasma
T4314	9456-9457	.	denotes	.
T4315	9457-9592	sentence	denotes	Platelet activation is observed as a morphological change from the resting discoid state to activated spherical cells with pseudopods.
T4316	9458-9466	NN	denotes	Platelet
T4317	9467-9477	NN	denotes	activation
T4318	9481-9489	VBN	denotes	observed
T4319	9478-9480	VBZ	denotes	is
T4320	9490-9492	IN	denotes	as
T4321	9493-9494	DT	denotes	a
T4322	9509-9515	NN	denotes	change
T4323	9495-9508	JJ	denotes	morphological
T4324	9516-9520	IN	denotes	from
T4325	9521-9524	DT	denotes	the
T4326	9541-9546	NN	denotes	state
T4327	9525-9532	VBG	denotes	resting
T4328	9533-9540	JJ	denotes	discoid
T4329	9547-9549	IN	denotes	to
T4330	9550-9559	VBN	denotes	activated
T4331	9570-9575	NNS	denotes	cells
T4332	9560-9569	JJ	denotes	spherical
T4333	9576-9580	IN	denotes	with
T4334	9581-9591	NNS	denotes	pseudopods
T4335	9591-9592	.	denotes	.
T4336	9592-9658	sentence	denotes	The morphological changes are due to cytoskeletal rearrangements.
T4337	9593-9596	DT	denotes	The
T4338	9611-9618	NNS	denotes	changes
T4339	9597-9610	JJ	denotes	morphological
T4340	9619-9622	VBP	denotes	are
T4341	9623-9626	IN	denotes	due
T4342	9627-9629	IN	denotes	to
T4343	9630-9642	JJ	denotes	cytoskeletal
T4344	9643-9657	NNS	denotes	rearrangements
T4345	9657-9658	.	denotes	.
T4346	9658-9780	sentence	denotes	In vitro the activated cells form aggregates recruiting additional cells in the solution thereby reducing its cloudiness.
T4347	9659-9661	FW	denotes	In
T4348	9662-9667	FW	denotes	vitro
T4349	9688-9692	VBP	denotes	form
T4350	9668-9671	DT	denotes	the
T4351	9682-9687	NNS	denotes	cells
T4352	9672-9681	VBN	denotes	activated
T4353	9693-9703	NNS	denotes	aggregates
T4354	9704-9714	VBG	denotes	recruiting
T4355	9715-9725	JJ	denotes	additional
T4356	9726-9731	NNS	denotes	cells
T4357	9732-9734	IN	denotes	in
T4358	9735-9738	DT	denotes	the
T4359	9739-9747	NN	denotes	solution
T4360	9748-9755	RB	denotes	thereby
T4361	9756-9764	VBG	denotes	reducing
T4362	9765-9768	PRP$	denotes	its
T4363	9769-9779	NN	denotes	cloudiness
T4364	9779-9780	.	denotes	.
T4365	9780-10079	sentence	denotes	Analysis of the transmission values of aggregation curves after platelet activation by ristocetin addition (von Willebrand cofactor) showed that both curves differed significantly at the time point of seven seconds after platelet initiation (p = 0.0287, n knock out = 16, n wild type = 15; Fig. 6).
T4366	9781-9789	NN	denotes	Analysis
T4367	9914-9920	VBD	denotes	showed
T4368	9790-9792	IN	denotes	of
T4369	9793-9796	DT	denotes	the
T4370	9810-9816	NNS	denotes	values
T4371	9797-9809	NN	denotes	transmission
T4372	9817-9819	IN	denotes	of
T4373	9820-9831	NN	denotes	aggregation
T4374	9832-9838	NNS	denotes	curves
T4375	9839-9844	IN	denotes	after
T4376	9845-9853	NN	denotes	platelet
T4377	9854-9864	NN	denotes	activation
T4378	9865-9867	IN	denotes	by
T4379	9868-9878	NN	denotes	ristocetin
T4380	9879-9887	NN	denotes	addition
T4381	9888-9889	-LRB-	denotes	(
T4382	9904-9912	NN	denotes	cofactor
T4383	9889-9892	NN	denotes	von
T4384	9893-9903	NN	denotes	Willebrand
T4385	9912-9913	-RRB-	denotes	)
T4386	9921-9925	IN	denotes	that
T4387	9938-9946	VBD	denotes	differed
T4388	9926-9930	DT	denotes	both
T4389	9931-9937	NNS	denotes	curves
T4390	9947-9960	RB	denotes	significantly
T4391	9961-9963	IN	denotes	at
T4392	9964-9967	DT	denotes	the
T4393	9973-9978	NN	denotes	point
T4394	9968-9972	NN	denotes	time
T4395	9979-9981	IN	denotes	of
T4396	9982-9987	CD	denotes	seven
T4397	9988-9995	NNS	denotes	seconds
T4398	9996-10001	IN	denotes	after
T4399	10002-10010	NN	denotes	platelet
T4400	10011-10021	NN	denotes	initiation
T4401	10022-10023	-LRB-	denotes	(
T4402	10071-10075	NN	denotes	Fig.
T4403	10023-10024	NN	denotes	p
T4404	10027-10033	CD	denotes	0.0287
T4405	10025-10026	SYM	denotes	=
T4406	10033-10035	,	denotes	,
T4407	10035-10036	NN	denotes	n
T4408	10043-10046	NN	denotes	out
T4409	10037-10042	NN	denotes	knock
T4410	10049-10051	CD	denotes	16
T4411	10047-10048	SYM	denotes	=
T4412	10051-10053	,	denotes	,
T4413	10053-10054	NN	denotes	n
T4414	10060-10064	NN	denotes	type
T4415	10055-10059	JJ	denotes	wild
T4416	10067-10069	CD	denotes	15
T4417	10065-10066	SYM	denotes	=
T4418	10069-10070	:	denotes	;
T4419	10076-10077	CD	denotes	6
T4420	10077-10078	-RRB-	denotes	)
T4421	10078-10079	.	denotes	.
T4422	10079-10158	sentence	denotes	Annexin A7 deficient platelets showed a slightly lowered aggregation velocity.
T4423	10080-10087	NN	denotes	Annexin
T4424	10088-10090	NN	denotes	A7
T4425	10091-10100	JJ	denotes	deficient
T4426	10101-10110	NNS	denotes	platelets
T4427	10111-10117	VBD	denotes	showed
T4428	10118-10119	DT	denotes	a
T4429	10149-10157	NN	denotes	velocity
T4430	10120-10128	RB	denotes	slightly
T4431	10129-10136	VBN	denotes	lowered
T4432	10137-10148	NN	denotes	aggregation
T4433	10157-10158	.	denotes	.
T4434	10158-10469	sentence	denotes	When we compared the aggregation curves of human platelets from a healthy donor with the ones obtained from an individual with a von Willebrand factor type 1 defect, we found that the difference in the curves was much more pronounced as observed in our studies of healthy mouse platelets and anxA7-/-platelets.
T4435	10159-10163	WRB	denotes	When
T4436	10167-10175	VBD	denotes	compared
T4437	10164-10166	PRP	denotes	we
T4438	10328-10333	VBD	denotes	found
T4439	10176-10179	DT	denotes	the
T4440	10192-10198	NNS	denotes	curves
T4441	10180-10191	NN	denotes	aggregation
T4442	10199-10201	IN	denotes	of
T4443	10202-10207	JJ	denotes	human
T4444	10208-10217	NNS	denotes	platelets
T4445	10218-10222	IN	denotes	from
T4446	10223-10224	DT	denotes	a
T4447	10233-10238	NN	denotes	donor
T4448	10225-10232	JJ	denotes	healthy
T4449	10239-10243	IN	denotes	with
T4450	10244-10247	DT	denotes	the
T4451	10248-10252	NNS	denotes	ones
T4452	10253-10261	VBN	denotes	obtained
T4453	10262-10266	IN	denotes	from
T4454	10267-10269	DT	denotes	an
T4455	10270-10280	NN	denotes	individual
T4456	10281-10285	IN	denotes	with
T4457	10286-10287	DT	denotes	a
T4458	10317-10323	NN	denotes	defect
T4459	10288-10291	NN	denotes	von
T4460	10292-10302	NN	denotes	Willebrand
T4461	10303-10309	NN	denotes	factor
T4462	10310-10314	NN	denotes	type
T4463	10315-10316	CD	denotes	1
T4464	10323-10325	,	denotes	,
T4465	10325-10327	PRP	denotes	we
T4466	10334-10338	IN	denotes	that
T4467	10368-10371	VBD	denotes	was
T4468	10339-10342	DT	denotes	the
T4469	10343-10353	NN	denotes	difference
T4470	10354-10356	IN	denotes	in
T4471	10357-10360	DT	denotes	the
T4472	10361-10367	NNS	denotes	curves
T4473	10372-10376	RB	denotes	much
T4474	10377-10381	RBR	denotes	more
T4475	10382-10392	JJ	denotes	pronounced
T4476	10393-10395	IN	denotes	as
T4477	10396-10404	VBN	denotes	observed
T4478	10405-10407	IN	denotes	in
T4479	10408-10411	PRP$	denotes	our
T4480	10412-10419	NNS	denotes	studies
T4481	10420-10422	IN	denotes	of
T4482	10423-10430	JJ	denotes	healthy
T4483	10437-10446	NNS	denotes	platelets
T4484	10431-10436	NN	denotes	mouse
T4485	10447-10450	CC	denotes	and
T4486	10451-10456	NN	denotes	anxA7
T4487	10459-10468	NNS	denotes	platelets
T4488	10456-10457	SYM	denotes	-
T4489	10457-10458	HYPH	denotes	/
T4490	10458-10459	SYM	denotes	-
T4491	10468-10469	.	denotes	.
T4492	10469-10608	sentence	denotes	Furthermore we found that murine platelets responded immediately to the initiating chemical whereas human platelets have a lag phase [23].
T4493	10470-10481	RB	denotes	Furthermore
T4494	10485-10490	VBD	denotes	found
T4495	10482-10484	PRP	denotes	we
T4496	10491-10495	IN	denotes	that
T4497	10513-10522	VBD	denotes	responded
T4498	10496-10502	JJ	denotes	murine
T4499	10503-10512	NNS	denotes	platelets
T4500	10523-10534	RB	denotes	immediately
T4501	10535-10537	IN	denotes	to
T4502	10538-10541	DT	denotes	the
T4503	10553-10561	NN	denotes	chemical
T4504	10542-10552	VBG	denotes	initiating
T4505	10562-10569	IN	denotes	whereas
T4506	10586-10590	VBP	denotes	have
T4507	10570-10575	JJ	denotes	human
T4508	10576-10585	NNS	denotes	platelets
T4509	10591-10592	DT	denotes	a
T4510	10597-10602	NN	denotes	phase
T4511	10593-10596	NN	denotes	lag
T4512	10603-10604	-LRB-	denotes	[
T4513	10604-10606	CD	denotes	23
T4514	10606-10607	-RRB-	denotes	]
T4515	10607-10608	.	denotes	.
T9089	761-771	NN	denotes	Expression
T9090	772-774	IN	denotes	of
T9091	775-782	NN	denotes	annexin
T9092	783-785	NN	denotes	A7
T9093	786-788	IN	denotes	in
T9094	789-794	JJ	denotes	human
T9095	805-810	NNS	denotes	cells
T9096	795-798	JJ	denotes	red
T9097	799-804	NN	denotes	blood
T9098	811-812	-LRB-	denotes	(
T9099	812-813	CD	denotes	1
T9100	813-814	-RRB-	denotes	)
T9101	815-818	CC	denotes	and
T9102	819-824	JJ	denotes	human
T9103	825-834	NNS	denotes	platelets
T9104	835-836	-LRB-	denotes	(
T9105	836-837	CD	denotes	2
T9106	837-838	-RRB-	denotes	)
T9107	838-839	.	denotes	.
T9108	839-905	sentence	denotes	Protein homogenates were separated by SDS-PAGE (12 % acrylamide).
T9109	840-847	NN	denotes	Protein
T9110	848-859	NNS	denotes	homogenates
T9111	865-874	VBN	denotes	separated
T9112	860-864	VBD	denotes	were
T9113	875-877	IN	denotes	by
T9114	878-881	NN	denotes	SDS
T9115	882-886	NN	denotes	PAGE
T9116	881-882	HYPH	denotes	-
T9117	887-888	-LRB-	denotes	(
T9118	893-903	NN	denotes	acrylamide
T9119	888-890	CD	denotes	12
T9120	891-892	NN	denotes	%
T9121	903-904	-RRB-	denotes	)
T9122	904-905	.	denotes	.
T9123	905-1039	sentence	denotes	The resulting western blot was probed with mAb 203–217, visualization was by a secondary peroxidase coupled antibody followed by ECL.
T9124	906-909	DT	denotes	The
T9125	928-932	NN	denotes	blot
T9126	910-919	VBG	denotes	resulting
T9127	920-927	JJ	denotes	western
T9128	937-943	VBN	denotes	probed
T9129	933-936	VBD	denotes	was
T9130	976-979	VBD	denotes	was
T9131	944-948	IN	denotes	with
T9132	949-952	NN	denotes	mAb
T9133	953-960	CD	denotes	203–217
T9134	960-962	,	denotes	,
T9135	962-975	NN	denotes	visualization
T9136	980-982	IN	denotes	by
T9137	983-984	DT	denotes	a
T9138	1014-1022	NN	denotes	antibody
T9139	985-994	JJ	denotes	secondary
T9140	995-1005	NN	denotes	peroxidase
T9141	1006-1013	VBN	denotes	coupled
T9142	1023-1031	VBN	denotes	followed
T9143	1032-1034	IN	denotes	by
T9144	1035-1038	NN	denotes	ECL
T9145	1038-1039	.	denotes	.
T9146	1039-1134	sentence	denotes	Both isoforms are detected in red blood cells, in platelets only the small isoform is present.
T9147	1040-1044	DT	denotes	Both
T9148	1045-1053	NNS	denotes	isoforms
T9149	1058-1066	VBN	denotes	detected
T9150	1054-1057	VBP	denotes	are
T9151	1123-1125	VBZ	denotes	is
T9152	1067-1069	IN	denotes	in
T9153	1070-1073	JJ	denotes	red
T9154	1080-1085	NNS	denotes	cells
T9155	1074-1079	NN	denotes	blood
T9156	1085-1087	,	denotes	,
T9157	1087-1089	IN	denotes	in
T9158	1090-1099	NNS	denotes	platelets
T9159	1100-1104	RB	denotes	only
T9160	1115-1122	NN	denotes	isoform
T9161	1105-1108	DT	denotes	the
T9162	1109-1114	JJ	denotes	small
T9163	1126-1133	JJ	denotes	present
T9164	1133-1134	.	denotes	.
T9240	2477-2487	NN	denotes	Enrichment
T9241	2488-2490	IN	denotes	of
T9242	2491-2498	NN	denotes	annexin
T9243	2499-2501	NN	denotes	A7
T9244	2502-2505	CC	denotes	and
T9245	2506-2512	NN	denotes	sorcin
T9246	2513-2515	IN	denotes	in
T9247	2516-2527	NNS	denotes	exovesicles
T9248	2528-2535	VBN	denotes	derived
T9249	2536-2540	IN	denotes	from
T9250	2541-2544	JJ	denotes	red
T9251	2551-2556	NNS	denotes	cells
T9252	2545-2550	NN	denotes	blood
T9253	2556-2557	.	denotes	.
T9254	2557-2779	sentence	denotes	Vesicles from wild type (wt) and anxA7-/- mutant (ko) were generated with Ca2+/ionophore treatment, isolated by differential centrifugation and analysed by immunoblotting with mAb 203–217 and a sorcin polyclonal antibody.
T9255	2558-2566	NNS	denotes	Vesicles
T9256	2617-2626	VBN	denotes	generated
T9257	2567-2571	IN	denotes	from
T9258	2572-2576	JJ	denotes	wild
T9259	2577-2581	NN	denotes	type
T9260	2582-2583	-LRB-	denotes	(
T9261	2583-2585	NN	denotes	wt
T9262	2585-2586	-RRB-	denotes	)
T9263	2587-2590	CC	denotes	and
T9264	2591-2596	JJ	denotes	anxA7
T9265	2600-2606	NN	denotes	mutant
T9266	2596-2597	SYM	denotes	-
T9267	2597-2598	HYPH	denotes	/
T9268	2598-2599	SYM	denotes	-
T9269	2607-2608	-LRB-	denotes	(
T9270	2608-2610	NN	denotes	ko
T9271	2610-2611	-RRB-	denotes	)
T9272	2612-2616	VBD	denotes	were
T9273	2627-2631	IN	denotes	with
T9274	2632-2636	NN	denotes	Ca2+
T9275	2637-2646	NN	denotes	ionophore
T9276	2636-2637	HYPH	denotes	/
T9277	2647-2656	NN	denotes	treatment
T9278	2656-2658	,	denotes	,
T9279	2658-2666	VBN	denotes	isolated
T9280	2667-2669	IN	denotes	by
T9281	2670-2682	JJ	denotes	differential
T9282	2683-2697	NN	denotes	centrifugation
T9283	2698-2701	CC	denotes	and
T9284	2702-2710	VBN	denotes	analysed
T9285	2711-2713	IN	denotes	by
T9286	2714-2728	VBG	denotes	immunoblotting
T9287	2729-2733	IN	denotes	with
T9288	2734-2737	NN	denotes	mAb
T9289	2738-2741	CD	denotes	203
T9290	2741-2742	SYM	denotes	–
T9291	2742-2745	CD	denotes	217
T9292	2746-2749	CC	denotes	and
T9293	2750-2751	DT	denotes	a
T9294	2770-2778	NN	denotes	antibody
T9295	2752-2758	NN	denotes	sorcin
T9296	2759-2769	JJ	denotes	polyclonal
T9297	2778-2779	.	denotes	.
T9298	2779-2848	sentence	denotes	In general, annexin A7 and sorcin are more abundant in nanovesicles.
T9299	2780-2782	IN	denotes	In
T9300	2814-2817	VBP	denotes	are
T9301	2783-2790	JJ	denotes	general
T9302	2790-2792	,	denotes	,
T9303	2792-2799	NN	denotes	annexin
T9304	2800-2802	NN	denotes	A7
T9305	2803-2806	CC	denotes	and
T9306	2807-2813	NN	denotes	sorcin
T9307	2818-2822	RBR	denotes	more
T9308	2823-2831	JJ	denotes	abundant
T9309	2832-2834	IN	denotes	in
T9310	2835-2847	NNS	denotes	nanovesicles
T9311	2847-2848	.	denotes	.
T9312	2848-2924	sentence	denotes	The 51 kDa isoform of annexin A7 (arrows) is only observed in nanovesicles.
T9313	2849-2852	DT	denotes	The
T9314	2860-2867	NN	denotes	isoform
T9315	2853-2855	CD	denotes	51
T9316	2856-2859	NN	denotes	kDa
T9317	2899-2907	VBN	denotes	observed
T9318	2868-2870	IN	denotes	of
T9319	2871-2878	NN	denotes	annexin
T9320	2879-2881	NN	denotes	A7
T9321	2882-2883	-LRB-	denotes	(
T9322	2883-2889	NNS	denotes	arrows
T9323	2889-2890	-RRB-	denotes	)
T9324	2891-2893	VBZ	denotes	is
T9325	2894-2898	RB	denotes	only
T9326	2908-2910	IN	denotes	in
T9327	2911-2923	NNS	denotes	nanovesicles
T9328	2923-2924	.	denotes	.
T9329	2924-3023	sentence	denotes	Samples of both vesicles types were normalized according to their acetylcholine esterase activity.
T9330	2925-2932	NNS	denotes	Samples
T9331	2961-2971	VBN	denotes	normalized
T9332	2933-2935	IN	denotes	of
T9333	2936-2940	DT	denotes	both
T9334	2950-2955	NNS	denotes	types
T9335	2941-2949	NNS	denotes	vesicles
T9336	2956-2960	VBD	denotes	were
T9337	2972-2981	VBG	denotes	according
T9338	2982-2984	IN	denotes	to
T9339	2985-2990	PRP$	denotes	their
T9340	3014-3022	NN	denotes	activity
T9341	2991-3004	NN	denotes	acetylcholine
T9342	3005-3013	NN	denotes	esterase
T9343	3022-3023	.	denotes	.
T9344	3023-3102	sentence	denotes	Human red blood cells (co) were used for control and normalized independently.
T9345	3024-3029	JJ	denotes	Human
T9346	3040-3045	NNS	denotes	cells
T9347	3030-3033	JJ	denotes	red
T9348	3034-3039	NN	denotes	blood
T9349	3056-3060	VBN	denotes	used
T9350	3046-3047	-LRB-	denotes	(
T9351	3047-3049	NN	denotes	co
T9352	3049-3050	-RRB-	denotes	)
T9353	3051-3055	VBD	denotes	were
T9354	3061-3064	IN	denotes	for
T9355	3065-3072	NN	denotes	control
T9356	3073-3076	CC	denotes	and
T9357	3077-3087	VBD	denotes	normalized
T9358	3088-3101	RB	denotes	independently
T9359	3101-3102	.	denotes	.
T9397	3950-3961	NN	denotes	Association
T9398	3962-3964	IN	denotes	of
T9399	3965-3972	NN	denotes	annexin
T9400	3973-3975	NN	denotes	A7
T9401	3976-3979	CC	denotes	and
T9402	3980-3986	NN	denotes	sorcin
T9403	3987-3991	IN	denotes	with
T9404	3992-4000	JJ	denotes	distinct
T9405	4032-4041	NNS	denotes	fractions
T9406	4001-4004	JJ	denotes	red
T9407	4011-4015	NN	denotes	cell
T9408	4005-4010	NN	denotes	blood
T9409	4016-4022	NN	denotes	plasma
T9410	4023-4031	NN	denotes	membrane
T9411	4041-4042	.	denotes	.
T9412	4042-4127	sentence	denotes	Lysed human red blood cells were added to a self forming iodixanol density gradient.
T9413	4043-4048	VBN	denotes	Lysed
T9414	4065-4070	NNS	denotes	cells
T9415	4049-4054	JJ	denotes	human
T9416	4055-4058	JJ	denotes	red
T9417	4059-4064	NN	denotes	blood
T9418	4076-4081	VBN	denotes	added
T9419	4071-4075	VBD	denotes	were
T9420	4082-4084	IN	denotes	to
T9421	4085-4086	DT	denotes	a
T9422	4118-4126	NN	denotes	gradient
T9423	4087-4091	NN	denotes	self
T9424	4092-4099	VBG	denotes	forming
T9425	4100-4109	NN	denotes	iodixanol
T9426	4110-4117	NN	denotes	density
T9427	4126-4127	.	denotes	.
T9428	4127-4209	sentence	denotes	The density of the gradient increases from left (1.06 g/ml) to right (1.20 g/ml).
T9429	4128-4131	DT	denotes	The
T9430	4132-4139	NN	denotes	density
T9431	4156-4165	VBZ	denotes	increases
T9432	4140-4142	IN	denotes	of
T9433	4143-4146	DT	denotes	the
T9434	4147-4155	NN	denotes	gradient
T9435	4166-4170	IN	denotes	from
T9436	4171-4175	JJ	denotes	left
T9437	4176-4177	-LRB-	denotes	(
T9438	4182-4183	NNS	denotes	g
T9439	4177-4181	CD	denotes	1.06
T9440	4183-4184	SYM	denotes	/
T9441	4184-4186	NN	denotes	ml
T9442	4186-4187	-RRB-	denotes	)
T9443	4188-4190	IN	denotes	to
T9444	4191-4196	JJ	denotes	right
T9445	4197-4198	-LRB-	denotes	(
T9446	4203-4204	NNS	denotes	g
T9447	4198-4202	CD	denotes	1.20
T9448	4204-4205	SYM	denotes	/
T9449	4205-4207	NN	denotes	ml
T9450	4207-4208	-RRB-	denotes	)
T9451	4208-4209	.	denotes	.
T9452	4209-4305	sentence	denotes	Fractions were analysed by immunoblotting using mAb 203–217 and the sorcin polyclonal antibody.
T9453	4210-4219	NNS	denotes	Fractions
T9454	4225-4233	VBN	denotes	analysed
T9455	4220-4224	VBD	denotes	were
T9456	4234-4236	IN	denotes	by
T9457	4237-4251	NN	denotes	immunoblotting
T9458	4252-4257	VBG	denotes	using
T9459	4258-4261	NN	denotes	mAb
T9460	4262-4265	CD	denotes	203
T9461	4265-4266	SYM	denotes	–
T9462	4266-4269	CD	denotes	217
T9463	4270-4273	CC	denotes	and
T9464	4274-4277	DT	denotes	the
T9465	4296-4304	NN	denotes	antibody
T9466	4278-4284	NN	denotes	sorcin
T9467	4285-4295	JJ	denotes	polyclonal
T9468	4304-4305	.	denotes	.
T9533	5259-5270	JJ	denotes	significant
T9534	5271-5272	-LRB-	denotes	(
T9535	5287-5289	CD	denotes	40
T9536	5272-5273	NN	denotes	p
T9537	5276-5281	CD	denotes	0.015
T9538	5274-5275	SYM	denotes	=
T9539	5281-5282	:	denotes	;
T9540	5283-5284	NN	denotes	n
T9541	5285-5286	SYM	denotes	=
T9542	5289-5290	-RRB-	denotes	)
T9543	5290-5291	.	denotes	.
T9544	5291-5302	sentence	denotes	Bar, 3 μm.
T9545	5292-5295	NN	denotes	Bar
T9546	5299-5301	NNS	denotes	μm
T9547	5295-5297	,	denotes	,
T9548	5297-5298	CD	denotes	3
T9549	5301-5302	.	denotes	.
T9617	7382-7389	JJ	denotes	Osmotic
T9618	7390-7400	NN	denotes	resistance
T9619	7401-7407	NNS	denotes	curves
T9620	7408-7410	IN	denotes	of
T9621	7411-7414	JJ	denotes	red
T9622	7421-7426	NNS	denotes	cells
T9623	7415-7420	NN	denotes	blood
T9624	7427-7431	IN	denotes	from
T9625	7432-7436	JJ	denotes	wild
T9626	7437-7441	NN	denotes	type
T9627	7462-7466	NNS	denotes	mice
T9628	7442-7445	CC	denotes	and
T9629	7446-7451	NN	denotes	anxA7
T9630	7451-7452	SYM	denotes	-
T9631	7452-7453	HYPH	denotes	/
T9632	7453-7454	SYM	denotes	-
T9633	7455-7461	JJ	denotes	mutant
T9634	7466-7467	.	denotes	.
T9635	7467-7610	sentence	denotes	The osmotic resistance towards changes in the extracellular ionic strength is a convenient assay for analysis of the red blood cell integrity.
T9636	7468-7471	DT	denotes	The
T9637	7480-7490	NN	denotes	resistance
T9638	7472-7479	JJ	denotes	osmotic
T9639	7543-7545	VBZ	denotes	is
T9640	7491-7498	IN	denotes	towards
T9641	7499-7506	NNS	denotes	changes
T9642	7507-7509	IN	denotes	in
T9643	7510-7513	DT	denotes	the
T9644	7534-7542	NN	denotes	strength
T9645	7514-7527	JJ	denotes	extracellular
T9646	7528-7533	JJ	denotes	ionic
T9647	7546-7547	DT	denotes	a
T9648	7559-7564	NN	denotes	assay
T9649	7548-7558	JJ	denotes	convenient
T9650	7565-7568	IN	denotes	for
T9651	7569-7577	NN	denotes	analysis
T9652	7578-7580	IN	denotes	of
T9653	7581-7584	DT	denotes	the
T9654	7600-7609	NN	denotes	integrity
T9655	7585-7588	JJ	denotes	red
T9656	7595-7599	NN	denotes	cell
T9657	7589-7594	NN	denotes	blood
T9658	7609-7610	.	denotes	.
T9659	7610-7777	sentence	denotes	It is measured as a sodium chloride concentration in which cellular lysis starts (minimal resistance) up to a complete lysis (maximal resistance) of a red blood cell.
T9660	7611-7613	PRP	denotes	It
T9661	7617-7625	VBN	denotes	measured
T9662	7614-7616	VBZ	denotes	is
T9663	7626-7628	IN	denotes	as
T9664	7629-7630	DT	denotes	a
T9665	7647-7660	NN	denotes	concentration
T9666	7631-7637	NN	denotes	sodium
T9667	7638-7646	NN	denotes	chloride
T9668	7661-7663	IN	denotes	in
T9669	7685-7691	VBZ	denotes	starts
T9670	7664-7669	WDT	denotes	which
T9671	7670-7678	JJ	denotes	cellular
T9672	7679-7684	NN	denotes	lysis
T9673	7692-7693	-LRB-	denotes	(
T9674	7701-7711	NN	denotes	resistance
T9675	7693-7700	JJ	denotes	minimal
T9676	7711-7712	-RRB-	denotes	)
T9677	7713-7715	IN	denotes	up
T9678	7716-7718	IN	denotes	to
T9679	7719-7720	DT	denotes	a
T9680	7730-7735	NN	denotes	lysis
T9681	7721-7729	JJ	denotes	complete
T9682	7736-7737	-LRB-	denotes	(
T9683	7745-7755	NN	denotes	resistance
T9684	7737-7744	JJ	denotes	maximal
T9685	7755-7756	-RRB-	denotes	)
T9686	7757-7759	IN	denotes	of
T9687	7760-7761	DT	denotes	a
T9688	7772-7776	NN	denotes	cell
T9689	7762-7765	JJ	denotes	red
T9690	7766-7771	NN	denotes	blood
T9691	7776-7777	.	denotes	.
T9692	7777-7922	sentence	denotes	The osmotic resistance of annexin A7 deficient red blood cells is significantly increased compared to the one of wild type (p = 0.00066; n = 8).
T9693	7778-7781	DT	denotes	The
T9694	7790-7800	NN	denotes	resistance
T9695	7782-7789	JJ	denotes	osmotic
T9696	7841-7843	VBZ	denotes	is
T9697	7801-7803	IN	denotes	of
T9698	7804-7811	NN	denotes	annexin
T9699	7812-7814	NN	denotes	A7
T9700	7815-7824	JJ	denotes	deficient
T9701	7835-7840	NNS	denotes	cells
T9702	7825-7828	JJ	denotes	red
T9703	7829-7834	NN	denotes	blood
T9704	7844-7857	RB	denotes	significantly
T9705	7858-7867	JJ	denotes	increased
T9706	7868-7876	VBN	denotes	compared
T9707	7877-7879	IN	denotes	to
T9708	7880-7883	DT	denotes	the
T9709	7884-7887	CD	denotes	one
T9710	7888-7890	IN	denotes	of
T9711	7891-7895	JJ	denotes	wild
T9712	7896-7900	NN	denotes	type
T9713	7901-7902	-LRB-	denotes	(
T9714	7919-7920	CD	denotes	8
T9715	7902-7903	NN	denotes	p
T9716	7906-7913	CD	denotes	0.00066
T9717	7904-7905	SYM	denotes	=
T9718	7913-7914	:	denotes	;
T9719	7915-7916	NN	denotes	n
T9720	7917-7918	SYM	denotes	=
T9721	7920-7921	-RRB-	denotes	)
T9722	7921-7922	.	denotes	.
T9783	10619-10627	NN	denotes	Platelet
T9784	10628-10639	NN	denotes	aggregation
T9785	10640-10646	NNS	denotes	curves
T9786	10647-10651	IN	denotes	from
T9787	10652-10660	NN	denotes	platelet
T9788	10661-10665	JJ	denotes	rich
T9789	10666-10672	NN	denotes	plasma
T9790	10673-10675	IN	denotes	of
T9791	10676-10683	NN	denotes	annexin
T9792	10684-10686	NN	denotes	A7
T9793	10711-10715	NNS	denotes	mice
T9794	10687-10692	NN	denotes	knock
T9795	10693-10696	NN	denotes	out
T9796	10697-10700	CC	denotes	and
T9797	10701-10705	JJ	denotes	wild
T9798	10706-10710	NN	denotes	type
T9799	10715-10716	.	denotes	.
T9800	10716-10831	sentence	denotes	The transmission values were measured with an APACT photometer and aggregation was initiated by adding ristocetin.
T9801	10717-10720	DT	denotes	The
T9802	10734-10740	NNS	denotes	values
T9803	10721-10733	NN	denotes	transmission
T9804	10746-10754	VBN	denotes	measured
T9805	10741-10745	VBD	denotes	were
T9806	10755-10759	IN	denotes	with
T9807	10760-10762	DT	denotes	an
T9808	10769-10779	NN	denotes	photometer
T9809	10763-10768	NN	denotes	APACT
T9810	10780-10783	CC	denotes	and
T9811	10784-10795	NN	denotes	aggregation
T9812	10800-10809	VBN	denotes	initiated
T9813	10796-10799	VBD	denotes	was
T9814	10810-10812	IN	denotes	by
T9815	10813-10819	VBG	denotes	adding
T9816	10820-10830	NN	denotes	ristocetin
T9817	10830-10831	.	denotes	.
T9818	10831-10867	sentence	denotes	The first thirty seconds are given.
T9819	10832-10835	DT	denotes	The
T9820	10849-10856	NNS	denotes	seconds
T9821	10836-10841	JJ	denotes	first
T9822	10842-10848	CD	denotes	thirty
T9823	10861-10866	VBN	denotes	given
T9824	10857-10860	VBP	denotes	are
T9825	10866-10867	.	denotes	.
T9826	10867-10930	sentence	denotes	Constant platelet counts were used throughout all experiments.
T9827	10868-10876	JJ	denotes	Constant
T9828	10886-10892	NNS	denotes	counts
T9829	10877-10885	NN	denotes	platelet
T9830	10898-10902	VBN	denotes	used
T9831	10893-10897	VBD	denotes	were
T9832	10903-10913	IN	denotes	throughout
T9833	10914-10917	DT	denotes	all
T9834	10918-10929	NNS	denotes	experiments
T9835	10929-10930	.	denotes	.
T9836	10930-11063	sentence	denotes	The aggregation curve data were analysed for slope values, the maximal aggregation amplitude of every single curve was set to 100 %.
T9837	10931-10934	DT	denotes	The
T9838	10953-10957	NNS	denotes	data
T9839	10935-10946	NN	denotes	aggregation
T9840	10947-10952	NN	denotes	curve
T9841	10963-10971	VBN	denotes	analysed
T9842	10958-10962	VBD	denotes	were
T9843	11050-11053	VBN	denotes	set
T9844	10972-10975	IN	denotes	for
T9845	10976-10981	NN	denotes	slope
T9846	10982-10988	NNS	denotes	values
T9847	10988-10990	,	denotes	,
T9848	10990-10993	DT	denotes	the
T9849	11014-11023	NN	denotes	amplitude
T9850	10994-11001	JJ	denotes	maximal
T9851	11002-11013	NN	denotes	aggregation
T9852	11024-11026	IN	denotes	of
T9853	11027-11032	DT	denotes	every
T9854	11040-11045	NN	denotes	curve
T9855	11033-11039	JJ	denotes	single
T9856	11046-11049	VBD	denotes	was
T9857	11054-11056	IN	denotes	to
T9858	11057-11060	CD	denotes	100
T9859	11061-11062	NN	denotes	%
T9860	11062-11063	.	denotes	.
T9861	11063-11439	sentence	denotes	Both murine curves differ significantly at a time point of seven seconds after platelet initiation, the mutant shows a slightly lower aggregation velocity (p = 0.0287, n knock out = 16, n wild type = 15, mean knock out = 67.7 % transmission, mean wild type = 77.1 % transmission, standard error knock out = 8.3 % transmission, standard error wild type = 13.8 % transmission).
T9862	11064-11068	DT	denotes	Both
T9863	11076-11082	NNS	denotes	curves
T9864	11069-11075	JJ	denotes	murine
T9865	11083-11089	VBP	denotes	differ
T9866	11175-11180	VBZ	denotes	shows
T9867	11090-11103	RB	denotes	significantly
T9868	11104-11106	IN	denotes	at
T9869	11107-11108	DT	denotes	a
T9870	11114-11119	NN	denotes	point
T9871	11109-11113	NN	denotes	time
T9872	11120-11122	IN	denotes	of
T9873	11123-11128	CD	denotes	seven
T9874	11129-11136	NNS	denotes	seconds
T9875	11137-11142	IN	denotes	after
T9876	11143-11151	NN	denotes	platelet
T9877	11152-11162	NN	denotes	initiation
T9878	11162-11164	,	denotes	,
T9879	11164-11167	DT	denotes	the
T9880	11168-11174	NN	denotes	mutant
T9881	11181-11182	DT	denotes	a
T9882	11210-11218	NN	denotes	velocity
T9883	11183-11191	RB	denotes	slightly
T9884	11192-11197	JJR	denotes	lower
T9885	11198-11209	NN	denotes	aggregation
T9886	11219-11220	-LRB-	denotes	(
T9887	11425-11437	NN	denotes	transmission
T9888	11220-11221	NN	denotes	p
T9889	11224-11230	CD	denotes	0.0287
T9890	11222-11223	SYM	denotes	=
T9891	11230-11232	,	denotes	,
T9892	11232-11233	NN	denotes	n
T9893	11240-11243	NN	denotes	out
T9894	11234-11239	NN	denotes	knock
T9895	11246-11248	CD	denotes	16
T9896	11244-11245	SYM	denotes	=
T9897	11248-11250	,	denotes	,
T9898	11250-11251	NN	denotes	n
T9899	11257-11261	NN	denotes	type
T9900	11252-11256	JJ	denotes	wild
T9901	11264-11266	CD	denotes	15
T9902	11262-11263	SYM	denotes	=
T9903	11266-11268	,	denotes	,
T9904	11268-11272	JJ	denotes	mean
T9905	11279-11282	NN	denotes	out
T9906	11273-11278	NN	denotes	knock
T9907	11292-11304	NN	denotes	transmission
T9908	11283-11284	SYM	denotes	=
T9909	11285-11289	CD	denotes	67.7
T9910	11290-11291	NN	denotes	%
T9911	11304-11306	,	denotes	,
T9912	11306-11310	JJ	denotes	mean
T9913	11316-11320	NN	denotes	type
T9914	11311-11315	JJ	denotes	wild
T9915	11330-11342	NN	denotes	transmission
T9916	11321-11322	SYM	denotes	=
T9917	11323-11327	CD	denotes	77.1
T9918	11328-11329	NN	denotes	%
T9919	11342-11344	,	denotes	,
T9920	11344-11352	JJ	denotes	standard
T9921	11353-11358	NN	denotes	error
T9922	11365-11368	NN	denotes	out
T9923	11359-11364	NN	denotes	knock
T9924	11377-11389	NN	denotes	transmission
T9925	11369-11370	SYM	denotes	=
T9926	11371-11374	CD	denotes	8.3
T9927	11375-11376	NN	denotes	%
T9928	11389-11391	,	denotes	,
T9929	11391-11399	JJ	denotes	standard
T9930	11400-11405	NN	denotes	error
T9931	11411-11415	NN	denotes	type
T9932	11406-11410	JJ	denotes	wild
T9933	11416-11417	SYM	denotes	=
T9934	11418-11422	CD	denotes	13.8
T9935	11423-11424	NN	denotes	%
T9936	11437-11438	-RRB-	denotes	)
T9937	11438-11439	.	denotes	.
T9938	11439-11556	sentence	denotes	Murine platelets react immediately to the initiating chemical and show no lag phase like the normal human platelets.
T9939	11440-11446	JJ	denotes	Murine
T9940	11447-11456	NNS	denotes	platelets
T9941	11457-11462	VBP	denotes	react
T9942	11463-11474	RB	denotes	immediately
T9943	11475-11477	IN	denotes	to
T9944	11478-11481	DT	denotes	the
T9945	11493-11501	NN	denotes	chemical
T9946	11482-11492	VBG	denotes	initiating
T9947	11502-11505	CC	denotes	and
T9948	11506-11510	VBP	denotes	show
T9949	11511-11513	DT	denotes	no
T9950	11518-11523	NN	denotes	phase
T9951	11514-11517	NN	denotes	lag
T9952	11524-11528	IN	denotes	like
T9953	11529-11532	DT	denotes	the
T9954	11546-11555	NNS	denotes	platelets
T9955	11533-11539	JJ	denotes	normal
T9956	11540-11545	JJ	denotes	human
T9957	11555-11556	.	denotes	.
T9958	11556-11690	sentence	denotes	For comparison of the range of the platelet impairment slightly affected human platelets are shown as well (von Willebrand syndrome).
T9959	11557-11560	IN	denotes	For
T9960	11650-11655	VBN	denotes	shown
T9961	11561-11571	NN	denotes	comparison
T9962	11572-11574	IN	denotes	of
T9963	11575-11578	DT	denotes	the
T9964	11579-11584	NN	denotes	range
T9965	11585-11587	IN	denotes	of
T9966	11588-11591	DT	denotes	the
T9967	11601-11611	NN	denotes	impairment
T9968	11592-11600	NN	denotes	platelet
T9969	11612-11620	RB	denotes	slightly
T9970	11621-11629	VBN	denotes	affected
T9971	11636-11645	NNS	denotes	platelets
T9972	11630-11635	JJ	denotes	human
T9973	11646-11649	VBP	denotes	are
T9974	11656-11658	RB	denotes	as
T9975	11659-11663	RB	denotes	well
T9976	11664-11665	-LRB-	denotes	(
T9977	11680-11688	NN	denotes	syndrome
T9978	11665-11668	NNP	denotes	von
T9979	11669-11679	NNP	denotes	Willebrand
T9980	11688-11689	-RRB-	denotes	)
T9981	11689-11690	.	denotes	.
T2865	3132-3139	NN	denotes	annexin
T2866	3140-3142	NN	denotes	A7
T2867	3143-3145	IN	denotes	in
T2868	3146-3149	JJ	denotes	red
T2869	3156-3161	NNS	denotes	cells
T9489	5065-5069	JJ	denotes	Dark
T9490	5070-5075	NN	denotes	field
T9491	5076-5086	NN	denotes	microscopy
T9492	5087-5089	IN	denotes	of
T9493	5090-5093	JJ	denotes	red
T9494	5100-5105	NNS	denotes	cells
T9495	5094-5099	NN	denotes	blood
T9496	5106-5110	IN	denotes	from
T9497	5111-5116	JJ	denotes	anxA7
T9498	5120-5126	NN	denotes	mutant
T9499	5116-5117	SYM	denotes	-
T9500	5117-5118	HYPH	denotes	/
T9501	5118-5119	SYM	denotes	-
T9502	5145-5149	NNS	denotes	mice
T9503	5127-5128	-LRB-	denotes	(
T9504	5128-5129	NN	denotes	B
T9505	5129-5130	-RRB-	denotes	)
T9506	5131-5134	CC	denotes	and
T9507	5135-5139	JJ	denotes	wild
T9508	5140-5144	NN	denotes	type
T9509	5150-5151	-LRB-	denotes	(
T9510	5151-5152	NN	denotes	A
T9511	5152-5153	-RRB-	denotes	)
T9512	5153-5154	.	denotes	.
T9513	5154-5219	sentence	denotes	The mean cellular diameters are 6.0 μm and 5.7 μm, respectively.
T9514	5155-5158	DT	denotes	The
T9515	5173-5182	NNS	denotes	diameters
T9516	5159-5163	JJ	denotes	mean
T9517	5164-5172	JJ	denotes	cellular
T9518	5183-5186	VBP	denotes	are
T9519	5187-5190	CD	denotes	6.0
T9520	5191-5193	NNS	denotes	μm
T9521	5194-5197	CC	denotes	and
T9522	5198-5201	CD	denotes	5.7
T9523	5202-5204	NNS	denotes	μm
T9524	5204-5206	,	denotes	,
T9525	5206-5218	RB	denotes	respectively
T9526	5218-5219	.	denotes	.
T9527	5219-5291	sentence	denotes	The size differences are statistically significant (p = 0.015; n = 40).
T9528	5220-5223	DT	denotes	The
T9529	5229-5240	NNS	denotes	differences
T9530	5224-5228	NN	denotes	size
T9531	5241-5244	VBP	denotes	are
T9532	5245-5258	RB	denotes	statistically
T2870	3150-3155	NN	denotes	blood
T2871	3162-3164	PRP	denotes	we
T2872	3170-3174	NN	denotes	self
T2873	3175-3182	VBG	denotes	forming
T2874	3201-3210	NNS	denotes	gradients
T2554	560-567	NN	denotes	isoform
T2555	553-555	CD	denotes	47
T2556	556-559	NN	denotes	kDa
T2557	572-580	VBN	denotes	detected
T2558	568-571	VBD	denotes	was
T2559	581-583	IN	denotes	in
T2560	584-590	NN	denotes	silver
T2561	591-598	VBN	denotes	stained
T2562	599-603	NNS	denotes	gels
T2563	604-607	CC	denotes	and
T2564	608-611	PRP$	denotes	its
T2565	612-620	NN	denotes	identity
T2566	637-646	VBN	denotes	confirmed
T2567	621-625	IN	denotes	with
T2568	626-633	NN	denotes	annexin
T2569	634-636	NN	denotes	A7
T2570	647-649	IN	denotes	by
T2571	650-657	NN	denotes	peptide
T2572	663-677	NN	denotes	fingerprinting
T2573	658-662	NN	denotes	mass
T2574	678-679	-LRB-	denotes	(
T2575	688-693	VBN	denotes	shown
T2576	679-683	NNS	denotes	data
T2577	684-687	RB	denotes	not
T2578	693-694	-RRB-	denotes	)
T2579	694-695	.	denotes	.
T2580	695-750	sentence	denotes	The 51 kDa isoform was only detected in western blots.
T2581	696-699	DT	denotes	The
T2582	707-714	NN	denotes	isoform
T2583	700-702	CD	denotes	51
T2584	703-706	NN	denotes	kDa
T2585	724-732	VBN	denotes	detected
T2586	715-718	VBD	denotes	was
T2587	719-723	RB	denotes	only
T2588	733-735	IN	denotes	in
T2589	736-743	JJ	denotes	western
T2590	744-749	NNS	denotes	blots
T2591	749-750	.	denotes	.
T2592	750-751	sentence	denotes
T2593	1135-1292	sentence	denotes	Its presence in vesicles led to the suggestion, that, along with raft domains, annexin A7 plays a role in membrane organization and the vesiculation process.
T2594	1135-1138	PRP$	denotes	Its
T2595	1139-1147	NN	denotes	presence
T2596	1160-1163	VBD	denotes	led
T2597	1148-1150	IN	denotes	in
T2598	1151-1159	NNS	denotes	vesicles
T2599	1164-1166	IN	denotes	to
T2600	1167-1170	DT	denotes	the
T2601	1171-1181	NN	denotes	suggestion
T2602	1181-1183	,	denotes	,
T2603	1183-1187	IN	denotes	that
T2604	1225-1230	VBZ	denotes	plays
T2605	1187-1189	,	denotes	,
T2875	3183-3192	NN	denotes	iodixanol
T2792	2144-2145	.	denotes	.
T2793	2145-2309	sentence	denotes	It appears that annexin A7, although it has been described to fuse membranes, is not a key component in the process of the formation of red blood cell exovesicles.
T2794	2146-2148	PRP	denotes	It
T2795	2149-2156	VBZ	denotes	appears
T2796	2157-2161	IN	denotes	that
T2797	2224-2226	VBZ	denotes	is
T2798	2162-2169	NN	denotes	annexin
T2799	2170-2172	NN	denotes	A7
T2800	2172-2174	,	denotes	,
T2801	2174-2182	IN	denotes	although
T2802	2195-2204	VBN	denotes	described
T2803	2183-2185	PRP	denotes	it
T2804	2186-2189	VBZ	denotes	has
T2805	2190-2194	VBN	denotes	been
T2806	2205-2207	TO	denotes	to
T2807	2208-2212	VB	denotes	fuse
T2808	2213-2222	NNS	denotes	membranes
T2809	2222-2224	,	denotes	,
T2810	2227-2230	RB	denotes	not
T2811	2231-2232	DT	denotes	a
T2812	2237-2246	NN	denotes	component
T2813	2233-2236	JJ	denotes	key
T2814	2247-2249	IN	denotes	in
T2815	2250-2253	DT	denotes	the
T2816	2254-2261	NN	denotes	process
T2817	2262-2264	IN	denotes	of
T2818	2265-2268	DT	denotes	the
T2819	2269-2278	NN	denotes	formation
T2820	2279-2281	IN	denotes	of
T2821	2282-2285	JJ	denotes	red
T2822	2292-2296	NN	denotes	cell
T2823	2286-2291	NN	denotes	blood
T2824	2297-2308	NNS	denotes	exovesicles
T2825	2308-2309	.	denotes	.
T2826	2309-2466	sentence	denotes	When we probed for the presence of sorcin in wild type and mutant vesicles we found that the sorcin levels were reduced in the mutant nanovesicles (Fig. 2).
T2827	2310-2314	WRB	denotes	When
T2828	2318-2324	VBD	denotes	probed
T2829	2315-2317	PRP	denotes	we
T2830	2388-2393	VBD	denotes	found
T2831	2325-2328	IN	denotes	for
T2858	2466-3211	sentence	denotes	Figure 2 Enrichment of annexin A7 and sorcin in exovesicles derived from red blood cells. Vesicles from wild type (wt) and anxA7-/- mutant (ko) were generated with Ca2+/ionophore treatment, isolated by differential centrifugation and analysed by immunoblotting with mAb 203–217 and a sorcin polyclonal antibody. In general, annexin A7 and sorcin are more abundant in nanovesicles. The 51 kDa isoform of annexin A7 (arrows) is only observed in nanovesicles. Samples of both vesicles types were normalized according to their acetylcholine esterase activity. Human red blood cells (co) were used for control and normalized independently. To study the distribution of annexin A7 in red blood cells we used self forming iodixanol density gradients.
T2859	3103-3105	TO	denotes	To
T2860	3106-3111	VB	denotes	study
T2861	3165-3169	VBD	denotes	used
T2862	3112-3115	DT	denotes	the
T2863	3116-3128	NN	denotes	distribution
T2864	3129-3131	IN	denotes	of
T2876	3193-3200	NN	denotes	density
T2877	3210-3211	.	denotes	.
T2878	3211-3355	sentence	denotes	Both isoforms were present in the soluble fraction as well as in the gradient fractions where they are assumed to be associated with membranes.
T2879	3212-3216	DT	denotes	Both
T3356	4695-4700	NN	denotes	shape
T3357	4701-4704	CC	denotes	and
T3358	4705-4713	NN	denotes	diameter
T3359	4714-4716	IN	denotes	of
T3360	4717-4720	DT	denotes	the
T3361	4739-4744	NNS	denotes	cells
T3362	4721-4726	JJ	denotes	anxA7
T3363	4726-4727	SYM	denotes	-
T3364	4727-4728	HYPH	denotes	/
T3365	4728-4729	SYM	denotes	-
T3366	4729-4732	JJ	denotes	red
T3367	4733-4738	NN	denotes	blood
T3368	4744-4745	.	denotes	.
T3369	4745-4949	sentence	denotes	They had a statistically significant larger cell diameter of 6.0 μm compared to wild type with 5.7 μm (p = 0.015, n = 40), a remarkably lower emphasized central impression and a more flat shape (Fig. 4).
T3370	4746-4750	PRP	denotes	They
T3371	4751-4754	VBD	denotes	had
T3372	4755-4756	DT	denotes	a
T3373	4795-4803	NN	denotes	diameter
T3374	4757-4770	RB	denotes	statistically
T3375	4771-4782	JJ	denotes	significant
T3376	4783-4789	JJR	denotes	larger
T3377	4790-4794	NN	denotes	cell
T3378	4804-4806	IN	denotes	of
T3379	4807-4810	CD	denotes	6.0
T3380	4811-4813	NN	denotes	μm
T3381	4814-4822	VBN	denotes	compared
T3436	5303-5394	sentence	denotes	Shape and MCV of a red blood cell essentially influence its function and capillary passage.
T3437	5303-5308	NN	denotes	Shape
T3438	5349-5358	VB	denotes	influence
T3439	5309-5312	CC	denotes	and
T3440	5313-5316	NN	denotes	MCV
T3441	5317-5319	IN	denotes	of
T3442	5320-5321	DT	denotes	a
T3443	5332-5336	NN	denotes	cell
T3444	5322-5325	JJ	denotes	red
T3445	5326-5331	NN	denotes	blood
T3446	5337-5348	RB	denotes	essentially
T3447	5359-5362	PRP$	denotes	its
T3448	5363-5371	NN	denotes	function
T3449	5372-5375	CC	denotes	and
T3450	5376-5385	JJ	denotes	capillary
T3451	5386-5393	NN	denotes	passage
T3452	5393-5394	.	denotes	.
T3453	5394-5568	sentence	denotes	The typical biconcave form depends on various influences including the membrane lipid composition and the submembranous cytoskeleton [32] where annexin A7 might play a role.
T3454	5395-5398	DT	denotes	The
T3455	5417-5421	NN	denotes	form
T3456	5399-5406	JJ	denotes	typical
T3457	5407-5416	NN	denotes	biconcave
T3458	5422-5429	VBZ	denotes	depends
T3459	5430-5432	IN	denotes	on
T3460	5433-5440	JJ	denotes	various
T3461	5441-5451	NNS	denotes	influences
T3462	5452-5461	VBG	denotes	including
T3463	5462-5465	DT	denotes	the
T3464	5481-5492	NN	denotes	composition
T3465	5466-5474	NN	denotes	membrane
T3466	5475-5480	NN	denotes	lipid
T3467	5493-5496	CC	denotes	and
T3468	5497-5500	DT	denotes	the
T3469	5515-5527	NN	denotes	cytoskeleton
T3470	5501-5514	JJ	denotes	submembranous
T3471	5528-5529	-LRB-	denotes	[
T3472	5529-5531	CD	denotes	32
T3473	5531-5532	-RRB-	denotes	]
T3474	5533-5538	WRB	denotes	where
T3715	6756-6759	DT	denotes	the
T3716	6784-6797	NN	denotes	deformability
T3717	6760-6763	JJ	denotes	red
R1264	T2443	T2444	compound	Annexin,A7
R1265	T2444	T2445	compound	A7,expression
R1266	T2446	T2445	prep	in,expression
R1267	T2447	T2448	amod	red,cells
R1268	T2448	T2446	pobj	cells,in
R1269	T2449	T2448	compound	blood,cells
R1270	T2450	T2448	punct	", ",cells
R1271	T2451	T2452	amod	red,cell
R1272	T2452	T2454	npadvmod	cell,derived
R1273	T2453	T2452	compound	blood,cell
R1274	T2454	T2455	amod	derived,exovesicles
R1275	T2455	T2448	appos	exovesicles,cells
R1276	T2456	T2446	cc	and,in
R1277	T2457	T2446	conj	in,in
R1278	T2458	T2457	pobj	platelets,in
R1279	T2460	T2461	nsubj	Salzer,reported
R1280	T2462	T2463	advmod	et,al.
R1281	T2463	T2460	advmod	al.,Salzer
R1282	T2464	T2461	advmod	recently,reported
R1283	T2465	T2466	det	the,presence
R1284	T2466	T2461	dobj	presence,reported
R1285	T2467	T2466	prep	of,presence
R1286	T2468	T2469	det	the,isoform
R1287	T2469	T2467	pobj	isoform,of
R1288	T2470	T2471	nummod	47,kDa
R1289	T2471	T2469	compound	kDa,isoform
R1290	T2472	T2469	prep	of,isoform
R1291	T2473	T2474	compound	annexin,A7
R1292	T2474	T2472	pobj	A7,of
R1293	T2475	T2474	cc	and,A7
R1294	T2476	T2477	poss	its,partner
R1295	T2477	T2474	conj	partner,A7
R1296	T2478	T2477	appos	sorcin,partner
R1297	T2479	T2469	prep	in,isoform
R1298	T2480	T2479	pobj	micro,in
R1299	T2481	T2480	punct	-,micro
R1300	T2482	T2480	cc	and,micro
R1301	T2483	T2480	conj	nanovesicles,micro
R1302	T2484	T2480	acl	derived,micro
R1303	T2485	T2484	prep	from,derived
R1304	T2486	T2487	amod	red,cells
R1305	T2487	T2485	pobj	cells,from
R1306	T2488	T2487	compound	blood,cells
R1307	T2489	T2490	advmod	where,located
R1308	T2490	T2487	relcl	located,cells
R1309	T2491	T2490	nsubjpass	they,located
R1310	T2492	T2490	auxpass	are,located
R1311	T2493	T2490	prep	in,located
R1312	T2494	T2495	det	the,lumen
R1313	T2495	T2493	pobj	lumen,in
R1314	T2496	T2490	cc	and,located
R1315	T2497	T2498	auxpass	are,enriched
R1316	T2498	T2490	conj	enriched,located
R1317	T2499	T2498	advmod	also,enriched
R1318	T2500	T2498	prep	in,enriched
R1319	T2501	T2502	compound	membrane,rafts
R1320	T2502	T2500	pobj	rafts,in
R1321	T2503	T2504	punct	[,7
R1322	T2504	T2461	parataxis	7,reported
R1323	T2505	T2504	punct	],7
R1324	T2506	T2461	punct	.,reported
R1325	T2508	T2509	nsubj	We,extended
R1326	T2510	T2509	aux	have,extended
R1327	T2511	T2509	advmod	now,extended
R1335	T2519	T2520	det	the,isoform
R1336	T2520	T2518	nsubj	isoform,is
R1337	T2521	T2522	nummod	51,kDa
R1338	T2522	T2520	compound	kDa,isoform
R1339	T2523	T2518	acomp	present,is
R1340	T2524	T2525	advmod	as,well
R1341	T2525	T2518	advmod	well,is
R1342	T2526	T2509	punct	.,extended
R1343	T2528	T2529	prep	In,detected
R1344	T2530	T2531	amod	western,blots
R1345	T2531	T2528	pobj	blots,In
R1346	T2532	T2531	prep	of,blots
R1347	T2533	T2534	amod	human,cells
R1348	T2534	T2532	pobj	cells,of
R1349	T2535	T2534	amod	red,cells
R1350	T2536	T2534	compound	blood,cells
R1351	T2537	T2538	det	the,isoforms
R1352	T2538	T2529	nsubjpass	isoforms,detected
R1353	T2539	T2540	nummod	47,kDa
R1354	T2540	T2538	compound	kDa,isoforms
R1355	T2541	T2539	cc	and,47
R1356	T2542	T2539	conj	51,47
R1357	T2543	T2529	auxpass	were,detected
R1358	T2544	T2529	advcl	using,detected
R1359	T2545	T2544	dobj	mAb,using
R1360	T2546	T2545	nummod	203–217,mAb
R1361	T2547	T2548	punct	(,Fig.
R1362	T2548	T2529	parataxis	Fig.,detected
R1363	T2549	T2548	nummod	1,Fig.
R1364	T2550	T2548	punct	),Fig.
R1365	T2551	T2529	punct	.,detected
R1366	T2553	T2554	det	The,isoform
R1367	T2554	T2557	nsubjpass	isoform,detected
R1368	T2555	T2556	nummod	47,kDa
R1369	T2556	T2554	compound	kDa,isoform
R1370	T2558	T2557	auxpass	was,detected
R1371	T2559	T2557	prep	in,detected
R1372	T2560	T2561	npadvmod	silver,stained
R1373	T2561	T2562	amod	stained,gels
R1374	T2562	T2559	pobj	gels,in
R1375	T2563	T2557	cc	and,detected
R1376	T2564	T2565	poss	its,identity
R1377	T2565	T2566	nsubj	identity,confirmed
R1378	T2566	T2557	conj	confirmed,detected
R1379	T2567	T2565	prep	with,identity
R1380	T2568	T2569	compound	annexin,A7
R1381	T2569	T2567	pobj	A7,with
R1382	T2570	T2566	prep	by,confirmed
R1383	T2571	T2572	compound	peptide,fingerprinting
R1384	T2572	T2570	pobj	fingerprinting,by
R1385	T2573	T2572	compound	mass,fingerprinting
R1386	T2574	T2575	punct	(,shown
R1387	T2575	T2566	parataxis	shown,confirmed
R1388	T2576	T2575	nsubj	data,shown
R1389	T2577	T2575	neg	not,shown
R1390	T2578	T2575	punct	),shown
R1391	T2579	T2566	punct	.,confirmed
R1392	T2581	T2582	det	The,isoform
R1393	T2582	T2585	nsubjpass	isoform,detected
R1394	T2583	T2584	nummod	51,kDa
R1395	T2584	T2582	compound	kDa,isoform
R1396	T2586	T2585	auxpass	was,detected
R1397	T2587	T2585	advmod	only,detected
R1398	T2588	T2585	prep	in,detected
R1399	T2589	T2590	amod	western,blots
R1400	T2590	T2588	pobj	blots,in
R1401	T2591	T2585	punct	.,detected
R1420	T2613	T2614	det	a,role
R1421	T2614	T2604	dobj	role,plays
R1422	T2615	T2604	prep	in,plays
R1423	T2616	T2617	compound	membrane,organization
R1424	T2617	T2615	pobj	organization,in
R1425	T2618	T2617	cc	and,organization
R1426	T2619	T2620	det	the,process
R1427	T2620	T2617	conj	process,organization
R1428	T2621	T2620	compound	vesiculation,process
R1429	T2622	T2596	punct	.,led
R1430	T2624	T2625	aux	To,examine
R1431	T2625	T2626	advcl	examine,analysed
R1432	T2627	T2625	dobj	this,examine
R1433	T2628	T2626	punct	", ",analysed
R1434	T2629	T2626	nsubj	we,analysed
R1435	T2630	T2631	det	the,ability
R1436	T2631	T2626	dobj	ability,analysed
R1437	T2632	T2631	prep	of,ability
R1438	T2633	T2634	amod	red,cells
R1439	T2634	T2632	pobj	cells,of
R1440	T2635	T2634	compound	blood,cells
R1441	T2636	T2634	acl	derived,cells
R1442	T2637	T2636	prep	from,derived
R1443	T2638	T2639	det	the,mice
R1444	T2639	T2637	pobj	mice,from
R1445	T2640	T2641	compound	annexin,A7
R1446	T2641	T2639	compound	A7,mice
R1447	T2642	T2643	compound	knock,out
R1448	T2643	T2639	compound	out,mice
R1449	T2644	T2645	punct	(,anxA7
R1450	T2645	T2639	parataxis	anxA7,mice
R1451	T2646	T2645	punct	-,anxA7
R1452	T2647	T2645	punct	/,anxA7
R1453	T2648	T2645	punct	-,anxA7
R1454	T2649	T2645	punct	),anxA7
R1455	T2650	T2651	aux	to,form
R1456	T2651	T2631	acl	form,ability
R1457	T2652	T2651	dobj	exovesicles,form
R1458	T2653	T2626	punct	.,analysed
R1459	T2655	T2656	prep	Because,included
R1460	T2657	T2655	pcomp	of,Because
R1461	T2658	T2659	amod	better,accessibility
R1462	T2659	T2655	pobj	accessibility,Because
R1463	T2660	T2659	cc	and,accessibility
R1464	T2661	T2662	amod	larger,amounts
R1465	T2662	T2659	conj	amounts,accessibility
R1466	T2663	T2662	amod	available,amounts
R1467	T2664	T2665	dep	that,led
R1468	T2665	T2659	relcl	led,accessibility
R1469	T2666	T2665	prep	to,led
R1470	T2667	T2668	amod	clear,results
R1471	T2668	T2666	pobj	results,to
R1472	T2669	T2656	punct	", ",included
R1473	T2670	T2656	nsubj	we,included
R1474	T2671	T2672	poss	our,data
R1475	T2672	T2656	dobj	data,included
R1476	T2673	T2672	acl	obtained,data
R1477	T2674	T2673	prep	with,obtained
R1478	T2675	T2676	amod	human,blood
R1479	T2676	T2674	pobj	blood,with
R1480	T2677	T2656	punct	.,included
R1481	T2679	T2680	advcl	Independent,released
R1482	T2681	T2679	prep	of,Independent
R1483	T2682	T2683	det	the,presence
R1484	T2683	T2681	pobj	presence,of
R1485	T2684	T2683	prep	of,presence
R1486	T2685	T2686	compound	annexin,A7
R1487	T2686	T2684	pobj	A7,of
R1488	T2687	T2688	det	both,types
R1489	T2688	T2680	nsubjpass	types,released
R1490	T2689	T2688	prep	of,types
R1491	T2690	T2689	pobj	exovesicles,of
R1492	T2691	T2688	punct	", ",types
R1493	T2692	T2693	nmod	micro,nanovesicles
R1494	T2693	T2688	appos	nanovesicles,types
R1495	T2694	T2693	punct	-,nanovesicles
R1496	T2695	T2693	cc	and,nanovesicles
R1497	T2696	T2680	punct	", ",released
R1498	T2697	T2680	auxpass	were,released
R1499	T2698	T2680	prep	after,released
R1500	T2699	T2700	compound	Ca2+,ionophore
R1501	T2700	T2702	compound	ionophore,treatment
R1502	T2701	T2700	punct	/,ionophore
R1503	T2702	T2698	pobj	treatment,after
R1504	T2703	T2704	mark	as,determined
R1505	T2704	T2680	advcl	determined,released
R1506	T2705	T2704	agent	by,determined
R1507	T2706	T2707	compound	acetylcholine,esterase
R1508	T2707	T2708	compound	esterase,activity
R1509	T2708	T2705	pobj	activity,by
R1510	T2709	T2708	cc	and,activity
R1511	T2710	T2711	amod	microscopic,examination
R1512	T2711	T2708	conj	examination,activity
R1513	T2712	T2680	punct	.,released
R1514	T2714	T2715	compound	Annexin,A7
R1515	T2715	T2716	nsubj	A7,is
R1516	T2717	T2716	acomp	present,is
R1517	T2718	T2716	prep	in,is
R1518	T2719	T2720	preconj	both,types
R1519	T2720	T2718	pobj	types,in
R1520	T2721	T2720	compound	vesicle,types
R1521	T2722	T2723	advmod	where,is
R1522	T2723	T2720	advcl	is,types
R1523	T2724	T2723	nsubj	it,is
R1524	T2725	T2726	advmod	more,enriched
R1525	T2726	T2723	acomp	enriched,is
R1526	T2727	T2723	prep	in,is
R1527	T2728	T2727	pobj	nanovesicles,in
R1528	T2729	T2730	punct	(,Fig.
R1529	T2730	T2716	parataxis	Fig.,is
R1530	T2731	T2730	nummod	2,Fig.
R1531	T2732	T2730	punct	),Fig.
R1532	T2733	T2716	punct	.,is
R1533	T2735	T2736	det	The,isoform
R1534	T2736	T2739	nsubj	isoform,is
R1535	T2737	T2738	nummod	51,kDa
R1536	T2738	T2736	compound	kDa,isoform
R1537	T2740	T2739	advmod	only,is
R1538	T2741	T2739	acomp	detectable,is
R1539	T2742	T2739	prep	in,is
R1540	T2743	T2742	pobj	nanovesicles,in
R1541	T2744	T2739	punct	.,is
R1542	T2746	T2747	det	The,quantity
R1543	T2747	T2748	nsubj	quantity,differ
R1544	T2749	T2747	prep	of,quantity
R1545	T2750	T2751	det	both,types
R1546	T2751	T2749	pobj	types,of
R1547	T2752	T2751	compound	vesicle,types
R1548	T2753	T2748	aux	did,differ
R1549	T2754	T2748	neg	not,differ
R1550	T2755	T2748	prep	between,differ
R1551	T2756	T2757	amod	wild,type
R1552	T2757	T2758	nmod	type,vesicles
R1553	T2758	T2755	pobj	vesicles,between
R1554	T2759	T2757	cc	and,type
R1555	T2760	T2761	compound	knock,out
R1556	T2761	T2757	conj	out,type
R1557	T2762	T2763	amod	red,cell
R1558	T2763	T2758	compound	cell,vesicles
R1559	T2764	T2763	compound	blood,cell
R1560	T2765	T2766	mark	as,determined
R1561	T2766	T2748	advcl	determined,differ
R1562	T2767	T2766	agent	by,determined
R1563	T2768	T2769	det	the,values
R1564	T2769	T2767	pobj	values,by
R1565	T2770	T2769	compound	AChE,values
R1566	T2771	T2769	punct	-,values
R1567	T2772	T2773	punct	(,both
R1568	T2773	T2769	parataxis	both,values
R1569	T2774	T2775	compound	A405,nanovesicles
R1570	T2775	T2776	dep	nanovesicles,0.18
R1571	T2776	T2773	dep	0.18,both
R1572	T2777	T2776	punct	: ,0.18
R1573	T2778	T2776	punct	~,0.18
R1574	T2779	T2773	punct	;,both
R1575	T2780	T2781	compound	A405,microvesicles
R1576	T2781	T2782	dep	microvesicles,0.9
R1577	T2782	T2773	dep	0.9,both
R1578	T2783	T2782	punct	: ,0.9
R1579	T2784	T2782	punct	~,0.9
R1580	T2785	T2773	punct	;,both
R1581	T2786	T2773	punct	", ",both
R1596	T2803	T2802	nsubjpass	it,described
R1597	T2804	T2802	aux	has,described
R1598	T2805	T2802	auxpass	been,described
R1599	T2806	T2807	aux	to,fuse
R1600	T2807	T2802	xcomp	fuse,described
R1601	T2808	T2807	dobj	membranes,fuse
R1602	T2809	T2797	punct	", ",is
R1603	T2810	T2797	neg	not,is
R1604	T2811	T2812	det	a,component
R1605	T2812	T2797	attr	component,is
R1606	T2813	T2812	amod	key,component
R1607	T2814	T2812	prep	in,component
R1608	T2815	T2816	det	the,process
R1609	T2816	T2814	pobj	process,in
R1610	T2817	T2816	prep	of,process
R1611	T2818	T2819	det	the,formation
R1612	T2819	T2817	pobj	formation,of
R1613	T2820	T2819	prep	of,formation
R1614	T2821	T2822	amod	red,cell
R1615	T2822	T2824	compound	cell,exovesicles
R1616	T2823	T2822	compound	blood,cell
R1617	T2824	T2820	pobj	exovesicles,of
R1618	T2825	T2795	punct	.,appears
R1619	T2827	T2828	advmod	When,probed
R1620	T2828	T2830	advcl	probed,found
R1621	T2829	T2828	nsubj	we,probed
R1622	T2831	T2828	prep	for,probed
R1623	T2832	T2833	det	the,presence
R1624	T2833	T2831	pobj	presence,for
R1625	T2834	T2833	prep	of,presence
R1626	T2835	T2834	pobj	sorcin,of
R1627	T2836	T2828	prep	in,probed
R1628	T2837	T2838	amod	wild,type
R1629	T2838	T2839	nmod	type,vesicles
R1630	T2839	T2836	pobj	vesicles,in
R1631	T2840	T2838	cc	and,type
R1632	T2841	T2838	conj	mutant,type
R1633	T2842	T2830	nsubj	we,found
R1634	T2843	T2844	mark	that,reduced
R1635	T2844	T2830	ccomp	reduced,found
R1636	T2845	T2846	det	the,levels
R1637	T2846	T2844	nsubjpass	levels,reduced
R1638	T2847	T2846	compound	sorcin,levels
R1639	T2848	T2844	auxpass	were,reduced
R1640	T2849	T2844	prep	in,reduced
R1641	T2850	T2851	det	the,nanovesicles
R1642	T2851	T2849	pobj	nanovesicles,in
R1643	T2852	T2851	amod	mutant,nanovesicles
R1644	T2853	T2854	punct	(,Fig.
R1645	T2854	T2830	parataxis	Fig.,found
R1646	T2855	T2854	nummod	2,Fig.
R1647	T2856	T2854	punct	),Fig.
R1648	T2857	T2830	punct	.,found
R1664	T2875	T2874	compound	iodixanol,gradients
R1665	T2876	T2874	compound	density,gradients
R1666	T2877	T2861	punct	.,used
R1667	T2879	T2880	det	Both,isoforms
R1668	T2880	T2881	nsubj	isoforms,were
R1669	T2882	T2881	acomp	present,were
R1670	T2883	T2881	prep	in,were
R1671	T2884	T2885	det	the,fraction
R1672	T2885	T2883	pobj	fraction,in
R1673	T2886	T2885	amod	soluble,fraction
R1674	T2887	T2888	advmod	as,as
R1675	T2888	T2883	cc	as,in
R1676	T2889	T2888	advmod	well,as
R1677	T2890	T2883	conj	in,in
R1678	T2891	T2892	det	the,fractions
R1679	T2892	T2890	pobj	fractions,in
R1680	T2893	T2892	compound	gradient,fractions
R1681	T2894	T2895	advmod	where,assumed
R1682	T2895	T2892	relcl	assumed,fractions
R1683	T2896	T2895	nsubjpass	they,assumed
R1684	T2897	T2895	auxpass	are,assumed
R1685	T2898	T2899	aux	to,associated
R1686	T2899	T2895	xcomp	associated,assumed
R1687	T2900	T2899	auxpass	be,associated
R1688	T2901	T2899	prep	with,associated
R1689	T2902	T2901	pobj	membranes,with
R1690	T2903	T2881	punct	.,were
R1691	T2905	T2906	det	These,membranes
R1692	T2906	T2907	nsubj	membranes,are
R1693	T2908	T2907	advmod	exclusively,are
R1694	T2909	T2910	compound	plasma,membranes
R1695	T2910	T2907	attr	membranes,are
R1696	T2911	T2912	mark	as,are
R1697	T2912	T2907	advcl	are,are
R1698	T2913	T2914	amod	red,cells
R1699	T2914	T2912	nsubj	cells,are
R1700	T2915	T2914	compound	blood,cells
R1701	T2916	T2912	acomp	free,are
R1702	T2917	T2916	prep	of,free
R1703	T2918	T2919	det	any,organelles
R1704	T2919	T2917	pobj	organelles,of
R1705	T2920	T2907	punct	.,are
R1706	T2922	T2923	det	The,distribution
R1707	T2923	T2924	nsubj	distribution,was
R1708	T2925	T2924	advmod	however,was
R1709	T2926	T2924	neg	not,was
R1710	T2927	T2924	acomp	homogeneous,was
R1711	T2928	T2924	prep	throughout,was
R1712	T2929	T2930	det	the,gradient
R1713	T2930	T2928	pobj	gradient,throughout
R1714	T2931	T2924	punct	.,was
R1715	T2933	T2934	nsubj	This,reflect
R1716	T2935	T2934	aux	could,reflect
R1717	T2936	T2937	det	the,binding
R1718	T2937	T2934	dobj	binding,reflect
R1719	T2938	T2937	prep	of,binding
R1720	T2939	T2940	compound	annexin,A7
R1721	T2940	T2938	pobj	A7,of
R1722	T2941	T2937	prep	to,binding
R1723	T2942	T2943	compound	membrane,subdomains
R1724	T2943	T2941	pobj	subdomains,to
R1725	T2944	T2945	dep	that,have
R1726	T2945	T2943	relcl	have,subdomains
R1727	T2946	T2947	amod	different,composition
R1728	T2947	T2945	dobj	composition,have
R1729	T2948	T2947	nmod	lipid,composition
R1730	T2949	T2948	cc	or,lipid
R1731	T2950	T2951	compound	lipid,protein
R1732	T2951	T2948	conj	protein,lipid
R1733	T2952	T2951	punct	/,protein
R1734	T2953	T2954	mark	as,discussed
R1735	T2954	T2934	advcl	discussed,reflect
R1736	T2955	T2954	agent	by,discussed
R1737	T2956	T2955	pobj	Salzer,by
R1738	T2957	T2958	advmod	et,al.
R1739	T2958	T2956	advmod	al.,Salzer
R1740	T2959	T2960	punct	[,7
R1741	T2960	T2934	parataxis	7,reflect
R1742	T2961	T2960	punct	],7
R1743	T2962	T2934	punct	.,reflect
R1744	T2964	T2965	advmod	Likewise,exhibit
R1745	T2966	T2965	punct	", ",exhibit
R1746	T2967	T2965	nsubj	sorcin,exhibit
R1747	T2968	T2965	aux	does,exhibit
R1748	T2969	T2965	neg	not,exhibit
R1749	T2970	T2971	det	a,distribution
R1750	T2971	T2965	dobj	distribution,exhibit
R1751	T2972	T2971	amod	homogeneous,distribution
R1752	T2973	T2965	prep	in,exhibit
R1753	T2974	T2975	det	the,gradient
R1754	T2975	T2973	pobj	gradient,in
R1755	T2976	T2965	punct	.,exhibit
R1756	T2978	T2979	advmod	Moreover,segregates
R1757	T2980	T2979	punct	", ",segregates
R1758	T2981	T2979	nsubj	it,segregates
R1759	T2982	T2979	prep	into,segregates
R1760	T2983	T2982	pobj	vesicles,into
R1761	T2984	T2985	dep	which,associated
R1762	T2985	T2983	relcl	associated,vesicles
R1763	T2986	T2985	auxpass	are,associated
R1764	T2987	T2985	neg	not,associated
R1765	T2988	T2985	prep	with,associated
R1766	T2989	T2990	compound	annexin,A7
R1767	T2990	T2988	pobj	A7,with
R1768	T2991	T2992	punct	(,Fig.
R1769	T2992	T2979	parataxis	Fig.,segregates
R1770	T2993	T2992	nummod	3,Fig.
R1771	T2994	T2992	punct	),Fig.
R1772	T2995	T2979	punct	.,segregates
R1773	T2997	T2998	nsubj	We,tested
R1774	T2999	T2998	advmod	also,tested
R1775	T3000	T2998	dobj	platelets,tested
R1776	T3001	T2998	prep	for,tested
R1777	T3002	T3003	compound	annexin,A7
R1778	T3003	T3004	compound	A7,expression
R1779	T3004	T3001	pobj	expression,for
R1780	T3005	T2998	cc	and,tested
R1781	T3006	T2998	conj	detected,tested
R1782	T3007	T3008	det	the,isoform
R1783	T3008	T3006	dobj	isoform,detected
R1784	T3009	T3010	nummod	47,kDa
R1785	T3010	T3008	compound	kDa,isoform
R1786	T3011	T3012	punct	(,Fig.
R1787	T3012	T3006	parataxis	Fig.,detected
R1788	T3013	T3012	nummod	1,Fig.
R1789	T3014	T3012	punct	),Fig.
R1790	T3015	T2998	punct	.,tested
R1795	T3280	T3281	det	The,lack
R1796	T3281	T3282	nsubj	lack,changes
R1797	T3283	T3281	prep	of,lack
R1798	T3284	T3285	compound	annexin,A7
R1799	T3285	T3283	pobj	A7,of
R1800	T3286	T3287	amod	red,cell
R1801	T3287	T3282	dobj	cell,changes
R1802	T3288	T3287	compound	blood,cell
R1803	T3289	T3287	appos	morphology,cell
R1804	T3290	T3289	cc	and,morphology
R1805	T3291	T3292	amod	osmotic,resistance
R1806	T3292	T3289	conj	resistance,morphology
R1807	T3294	T3295	mark	As,is
R1808	T3295	T3298	advcl	is,studied
R1809	T3296	T3297	compound	annexin,A7
R1810	T3297	T3295	nsubj	A7,is
R1811	T3299	T3300	det	a,component
R1812	T3300	T3295	attr	component,is
R1813	T3301	T3300	prep	of,component
R1814	T3302	T3303	amod	red,cell
R1815	T3303	T3305	compound	cell,vesicles
R1816	T3304	T3303	compound	blood,cell
R1817	T3305	T3301	pobj	vesicles,of
R1818	T3306	T3298	nsubj	we,studied
R1819	T3307	T3308	det	the,consequences
R1820	T3308	T3298	dobj	consequences,studied
R1821	T3309	T3308	prep	of,consequences
R1822	T3310	T3311	det	the,loss
R1823	T3311	T3309	pobj	loss,of
R1824	T3312	T3311	prep	of,loss
R1825	T3313	T3314	det	the,protein
R1826	T3314	T3312	pobj	protein,of
R1827	T3315	T3298	prep	in,studied
R1828	T3316	T3317	det	the,mouse
R1829	T3317	T3315	pobj	mouse,in
R1830	T3318	T3317	nmod	anxA7,mouse
R1831	T3319	T3318	punct	-,anxA7
R1832	T3320	T3318	punct	/,anxA7
R1833	T3321	T3318	punct	-,anxA7
R1834	T3322	T3298	prep	for,studied
R1835	T3323	T3324	amod	red,cell
R1836	T3324	T3322	pobj	cell,for
R1837	T3325	T3324	compound	blood,cell
R1838	T3326	T3324	appos	morphology,cell
R1839	T3327	T3326	cc	and,morphology
R1840	T3328	T3329	amod	osmotic,resistance
R1841	T3329	T3326	conj	resistance,morphology
R1842	T3330	T3298	punct	.,studied
R1843	T3332	T3333	prep	In,revealed
R1844	T3334	T3335	det	a,smear
R1845	T3335	T3332	pobj	smear,In
R1846	T3336	T3335	amod	standard,smear
R1847	T3337	T3335	punct	',smear
R1848	T3338	T3335	compound	blood,smear
R1849	T3339	T3333	punct	',revealed
R1850	T3340	T3341	nsubj	we,note
R1851	T3341	T3333	ccomp	note,revealed
R1852	T3342	T3341	aux	did,note
R1853	T3343	T3341	neg	not,note
R1854	T3344	T3345	det	a,deformation
R1855	T3345	T3341	dobj	deformation,note
R1856	T3346	T3345	prep	of,deformation
R1857	T3347	T3348	det	the,cells
R1858	T3348	T3346	pobj	cells,of
R1859	T3349	T3333	punct	", ",revealed
R1860	T3350	T3333	advmod	however,revealed
R1861	T3351	T3352	amod	dark,field
R1862	T3352	T3353	compound	field,microscopy
R1863	T3353	T3333	nsubj	microscopy,revealed
R1864	T3354	T3333	dobj	changes,revealed
R1865	T3355	T3354	prep	in,changes
R1866	T3356	T3355	pobj	shape,in
R1867	T3357	T3356	cc	and,shape
R1868	T3358	T3356	conj	diameter,shape
R1869	T3359	T3356	prep	of,shape
R1870	T3360	T3361	det	the,cells
R1871	T3361	T3359	pobj	cells,of
R1872	T3362	T3361	nmod	anxA7,cells
R1873	T3363	T3362	punct	-,anxA7
R1874	T3364	T3362	punct	/,anxA7
R1875	T3365	T3362	punct	-,anxA7
R1876	T3366	T3361	amod	red,cells
R1877	T3367	T3361	compound	blood,cells
R1878	T3368	T3333	punct	.,revealed
R1879	T3370	T3371	nsubj	They,had
R1880	T3372	T3373	det	a,diameter
R1902	T3394	T3389	nsubj	n,40
R1903	T3395	T3389	punct	=,40
R1904	T3396	T3389	punct	),40
R1905	T3397	T3373	punct	", ",diameter
R1906	T3398	T3399	det	a,impression
R1907	T3399	T3373	conj	impression,diameter
R1908	T3400	T3401	advmod	remarkably,lower
R1909	T3401	T3399	amod	lower,impression
R1910	T3402	T3399	amod	emphasized,impression
R1911	T3403	T3399	amod	central,impression
R1912	T3404	T3399	cc	and,impression
R1913	T3405	T3406	det	a,shape
R1914	T3406	T3399	conj	shape,impression
R1915	T3407	T3408	advmod	more,flat
R1916	T3408	T3406	amod	flat,shape
R1917	T3409	T3410	punct	(,Fig.
R1918	T3410	T3406	parataxis	Fig.,shape
R1919	T3411	T3410	nummod	4,Fig.
R1920	T3412	T3410	punct	),Fig.
R1921	T3413	T3371	punct	.,had
R1922	T3415	T3416	det	No,change
R1923	T3416	T3418	nsubjpass	change,measured
R1924	T3417	T3416	amod	significant,change
R1925	T3419	T3416	prep	in,change
R1926	T3420	T3421	det	the,volume
R1927	T3421	T3419	pobj	volume,in
R1928	T3422	T3421	amod	mean,volume
R1929	T3423	T3421	amod	corpuscular,volume
R1930	T3424	T3421	punct	(,volume
R1931	T3425	T3421	appos	MCV,volume
R1932	T3426	T3418	punct	),measured
R1933	T3427	T3418	auxpass	was,measured
R1934	T3428	T3418	prep	with,measured
R1935	T3429	T3430	det	the,counter
R1936	T3430	T3428	pobj	counter,with
R1937	T3431	T3430	nmod	ADVIA,counter
R1938	T3432	T3431	nummod	120,ADVIA
R1939	T3433	T3430	compound	cell,counter
R1940	T3434	T3418	punct	.,measured
R1975	T3474	T3475	advmod	where,play
R1976	T3475	T3469	relcl	play,cytoskeleton
R1977	T3476	T3477	compound	annexin,A7
R1978	T3477	T3475	nsubj	A7,play
R1979	T3478	T3475	aux	might,play
R1980	T3479	T3480	det	a,role
R1981	T3480	T3475	dobj	role,play
R1982	T3481	T3458	punct	.,depends
R1983	T3483	T3484	det	The,resistance
R1984	T3484	T3486	nsubj	resistance,is
R1985	T3485	T3484	amod	osmotic,resistance
R1986	T3487	T3484	punct	", ",resistance
R1987	T3488	T3489	dep	which,is
R1988	T3489	T3484	relcl	is,resistance
R1989	T3490	T3491	det	the,resistance
R1990	T3491	T3489	attr	resistance,is
R1991	T3492	T3491	prep	towards,resistance
R1992	T3493	T3492	pobj	changes,towards
R1993	T3494	T3489	prep	in,is
R1994	T3495	T3496	det	the,strength
R1995	T3496	T3494	pobj	strength,in
R1996	T3497	T3496	amod	extracellular,strength
R1997	T3498	T3496	amod	ionic,strength
R1998	T3499	T3486	punct	", ",is
R1999	T3500	T3501	det	a,assay
R2000	T3501	T3486	attr	assay,is
R2001	T3502	T3501	amod	convenient,assay
R2002	T3503	T3501	prep	for,assay
R2003	T3504	T3503	pobj	analysis,for
R2004	T3505	T3504	prep	of,analysis
R2005	T3506	T3507	det	the,integrity
R2006	T3507	T3505	pobj	integrity,of
R2007	T3508	T3509	amod	red,cell
R2008	T3509	T3507	compound	cell,integrity
R2009	T3510	T3509	compound	blood,cell
R2010	T3511	T3486	punct	.,is
R2011	T3513	T3514	nsubjpass	It,measured
R2012	T3515	T3514	auxpass	is,measured
R2013	T3516	T3514	prep	as,measured
R2014	T3517	T3518	det	the,concentration
R2015	T3518	T3516	pobj	concentration,as
R2016	T3519	T3520	compound	sodium,chloride
R2017	T3520	T3518	compound	chloride,concentration
R2018	T3521	T3522	prep	at,starts
R2019	T3522	T3518	relcl	starts,concentration
R2020	T3523	T3521	pobj	which,at
R2021	T3524	T3525	amod	cellular,lysis
R2022	T3525	T3522	nsubj	lysis,starts
R2023	T3526	T3518	punct	(,concentration
R2024	T3527	T3528	amod	minimal,resistance
R2025	T3528	T3518	appos	resistance,concentration
R2026	T3529	T3518	punct	),concentration
R2027	T3530	T3518	prep	up,concentration
R2028	T3531	T3530	prep	to,up
R2029	T3532	T3533	det	a,lysis
R2030	T3533	T3531	pobj	lysis,to
R2031	T3534	T3533	amod	complete,lysis
R2032	T3535	T3533	punct	(,lysis
R2033	T3536	T3537	amod	maximal,resistance
R2034	T3537	T3533	appos	resistance,lysis
R2035	T3538	T3533	punct	),lysis
R2036	T3539	T3533	prep	of,lysis
R2037	T3540	T3541	det	the,cells
R2038	T3541	T3539	pobj	cells,of
R2039	T3542	T3543	punct	[,33
R2040	T3543	T3514	parataxis	33,measured
R2041	T3544	T3543	punct	],33
R2042	T3545	T3514	punct	.,measured
R2043	T3547	T3548	amod	Osmotic,resistance
R2044	T3548	T3549	nsubj	resistance,increases
R2045	T3550	T3549	prep	with,increases
R2046	T3551	T3552	amod	higher,MCV
R2047	T3552	T3550	pobj	MCV,with
R2048	T3553	T3552	punct	", ",MCV
R2049	T3554	T3555	amod	larger,area
R2050	T3555	T3552	conj	area,MCV
R2051	T3556	T3555	compound	surface,area
R2052	T3557	T3555	cc	and,area
R2053	T3558	T3559	det	a,degree
R2054	T3559	T3555	conj	degree,area
R2055	T3560	T3559	amod	higher,degree
R2056	T3561	T3559	prep	of,degree
R2057	T3562	T3563	amod	cellular,metabolism
R2058	T3563	T3561	pobj	metabolism,of
R2059	T3564	T3552	acl	stabilizing,MCV
R2060	T3565	T3566	det	the,levels
R2061	T3566	T3564	dobj	levels,stabilizing
R2062	T3567	T3566	amod	intracellular,levels
R2063	T3568	T3566	compound	ion,levels
R2064	T3569	T3549	punct	.,increases
R2065	T3571	T3572	amod	Aged,cells
R2066	T3572	T3575	nsubj	cells,show
R2067	T3573	T3572	amod	red,cells
R2068	T3574	T3572	compound	blood,cells
R2069	T3576	T3577	det	a,MCV
R2070	T3577	T3575	dobj	MCV,show
R2071	T3578	T3577	amod	lowered,MCV
R2072	T3579	T3577	cc	and,MCV
R2073	T3580	T3581	amod	lower,resistance
R2074	T3581	T3577	conj	resistance,MCV
R2075	T3582	T3581	amod	osmotic,resistance
R2076	T3583	T3584	punct	[,33
R2077	T3584	T3575	parataxis	33,show
R2078	T3585	T3584	punct	],33
R2079	T3586	T3575	punct	.,show
R2080	T3588	T3589	amod	Similar,properties
R2081	T3589	T3590	nsubjpass	properties,observed
R2082	T3591	T3590	aux	can,observed
R2083	T3592	T3590	auxpass	be,observed
R2084	T3593	T3590	prep	in,observed
R2085	T3594	T3595	amod	red,cells
R2086	T3595	T3593	pobj	cells,in
R2087	T3596	T3595	compound	blood,cells
R2088	T3597	T3595	prep	with,cells
R2089	T3598	T3599	amod	lowered,permeability
R2090	T3599	T3597	pobj	permeability,with
R2091	T3600	T3599	compound	membrane,permeability
R2092	T3601	T3590	punct	.,observed
R2093	T3603	T3604	det	The,resistance
R2094	T3604	T3606	nsubj	resistance,is
R2095	T3605	T3604	amod	osmotic,resistance
R2096	T3607	T3604	prep	of,resistance
R2097	T3608	T3609	compound	annexin,A7
R2098	T3609	T3610	npadvmod	A7,deficient
R2099	T3610	T3611	amod	deficient,cells
R2100	T3611	T3607	pobj	cells,of
R2101	T3612	T3611	amod	red,cells
R2102	T3613	T3611	compound	blood,cells
R2103	T3614	T3615	advmod	significantly,increased
R2104	T3615	T3606	acomp	increased,is
R2105	T3616	T3606	prep	compared,is
R2106	T3617	T3616	prep	to,compared
R2107	T3618	T3619	amod	wild,type
R2108	T3619	T3620	compound	type,cells
R2109	T3620	T3617	pobj	cells,to
R2110	T3621	T3606	punct	.,is
R2111	T3623	T3624	det	The,value
R2112	T3624	T3627	nsubjpass	value,observed
R2113	T3625	T3626	amod	minimal,resistance
R2114	T3626	T3624	compound	resistance,value
R2115	T3628	T3624	prep	of,value
R2116	T3629	T3630	compound	knock,out
R2117	T3630	T3631	compound	out,cells
R2118	T3631	T3628	pobj	cells,of
R2119	T3632	T3627	auxpass	is,observed
R2120	T3633	T3627	prep	in,observed
R2121	T3634	T3635	det	a,solution
R2122	T3635	T3633	pobj	solution,in
R2123	T3636	T3637	nummod	0.60,%
R2124	T3637	T3635	compound	%,solution
R2125	T3638	T3635	compound	NaCl,solution
R2126	T3639	T3635	cc	versus,solution
R2127	T3640	T3641	nummod	0.65,%
R2128	T3641	T3635	conj	%,solution
R2129	T3642	T3641	prep	for,%
R2130	T3643	T3644	amod	wild,type
R2131	T3644	T3645	compound	type,cells
R2132	T3645	T3642	pobj	cells,for
R2133	T3646	T3627	punct	.,observed
R2134	T3648	T3649	nummod	50,%
R2135	T3649	T3650	compound	%,haemolysis
R2136	T3650	T3651	nsubjpass	haemolysis,achieved
R2137	T3652	T3651	auxpass	is,achieved
R2138	T3653	T3651	prep	at,achieved
R2139	T3654	T3655	nummod	0.516,%
R2140	T3655	T3656	compound	%,solution
R2141	T3656	T3653	pobj	solution,at
R2142	T3657	T3656	compound	NaCl,solution
R2143	T3658	T3656	prep	for,solution
R2144	T3659	T3660	compound	knock,out
R2145	T3660	T3658	pobj	out,for
R2146	T3661	T3656	cc	versus,solution
R2147	T3662	T3663	nummod	0.564,%
R2148	T3663	T3664	compound	%,NaCl
R2149	T3664	T3656	conj	NaCl,solution
R2150	T3665	T3664	prep	for,NaCl
R2151	T3666	T3667	amod	wild,type
R2152	T3667	T3668	compound	type,cells
R2153	T3668	T3665	pobj	cells,for
R2154	T3669	T3670	punct	(,Fig.
R2155	T3670	T3651	parataxis	Fig.,achieved
R2156	T3671	T3672	compound	mean,values
R2157	T3672	T3670	dep	values,Fig.
R2158	T3673	T3670	punct	", ",Fig.
R2159	T3674	T3675	nsubj	p,0.00066
R2160	T3675	T3670	ccomp	0.00066,Fig.
R2161	T3676	T3675	punct	=,0.00066
R2162	T3677	T3670	punct	", ",Fig.
R2163	T3678	T3679	nsubj	n,8
R2164	T3679	T3670	ccomp	8,Fig.
R2165	T3680	T3679	punct	=,8
R2166	T3681	T3670	punct	;,Fig.
R2167	T3682	T3670	nummod	5,Fig.
R2168	T3683	T3670	punct	),Fig.
R2169	T3684	T3651	punct	.,achieved
R2170	T3686	T3687	det	The,width
R2171	T3687	T3689	nsubj	width,is
R2172	T3688	T3687	compound	resistance,width
R2173	T3690	T3687	prep	of,width
R2174	T3691	T3692	det	the,cells
R2175	T3692	T3690	pobj	cells,of
R2176	T3693	T3694	compound	knock,out
R2177	T3694	T3692	compound	out,cells
R2178	T3695	T3696	advmod	slightly,lower
R2179	T3696	T3689	acomp	lower,is
R2180	T3697	T3698	punct	(,solution
R2181	T3698	T3696	parataxis	solution,lower
R2182	T3699	T3700	nummod	0.20,%
R2183	T3700	T3701	nmod	%,NaCl
R2184	T3701	T3698	compound	NaCl,solution
R2185	T3702	T3703	advmod	instead,of
R2186	T3703	T3700	cc	of,%
R2187	T3704	T3705	nummod	0.25,%
R2188	T3705	T3700	conj	%,%
R2189	T3706	T3698	punct	),solution
R2190	T3707	T3689	punct	.,is
R2191	T3709	T3710	nsubj	We,performed
R2192	T3711	T3710	advmod	also,performed
R2193	T3712	T3713	amod	direct,measurements
R2194	T3713	T3710	dobj	measurements,performed
R2195	T3714	T3713	prep	of,measurements
R2196	T3715	T3716	det	the,deformability
R2197	T3716	T3714	pobj	deformability,of
R2198	T3717	T3718	amod	red,cell
R2199	T3718	T3716	compound	cell,deformability
R2200	T3719	T3718	compound	blood,cell
R2201	T3720	T3716	compound	membrane,deformability
R2202	T3721	T3710	punct	", ",performed
R2203	T3722	T3723	aux	to,characterize
R2204	T3723	T3710	advcl	characterize,performed
R2205	T3724	T3723	advmod	further,characterize
R2206	T3725	T3726	det	a,role
R2207	T3726	T3723	dobj	role,characterize
R2208	T3727	T3726	amod	possible,role
R2209	T3728	T3726	prep	of,role
R2210	T3729	T3730	compound	annexin,A7
R2211	T3730	T3728	pobj	A7,of
R2212	T3731	T3726	prep	on,role
R2213	T3732	T3733	det	the,stability
R2214	T3733	T3731	pobj	stability,on
R2215	T3734	T3733	compound	membrane,stability
R2216	T3735	T3710	punct	.,performed
R2217	T3737	T3738	prep	With,tried
R2218	T3739	T3740	compound	micropipette,experiments
R2219	T3740	T3737	pobj	experiments,With
R2220	T3741	T3738	nsubj	we,tried
R2221	T3742	T3743	aux	to,correlate
R2222	T3743	T3738	xcomp	correlate,tried
R2223	T3744	T3745	amod	mechanical,characteristics
R2224	T3745	T3743	dobj	characteristics,correlate
R2225	T3746	T3745	prep	of,characteristics
R2226	T3747	T3748	det	the,cells
R2227	T3748	T3746	pobj	cells,of
R2228	T3749	T3748	amod	red,cells
R2229	T3750	T3748	compound	blood,cells
R2230	T3751	T3743	prep	with,correlate
R2250	T3773	T3774	det	these,experiments
R2251	T3774	T3772	pobj	experiments,in
R2252	T3775	T3776	punct	(,M.
R2253	T3776	T3757	meta	M.,observe
R2254	T3777	T3776	nmod	Heil,M.
R2255	T3778	T3776	punct	", ",M.
R2256	T3779	T3776	conj	B.,M.
R2257	T3780	T3779	nmod	Hoffmann,B.
R2258	T3781	T3779	cc	and,B.
R2259	T3782	T3779	conj	R.,B.
R2260	T3783	T3782	nmod	Merkel,R.
R2261	T3784	T3782	punct	", ",R.
R2262	T3785	T3786	amod	unpublished,results
R2263	T3786	T3782	conj	results,R.
R2264	T3787	T3786	punct	),results
R2265	T3788	T3757	punct	.,observe
R2266	T3790	T3791	advmod	However,was
R2267	T3792	T3791	punct	", ",was
R2268	T3793	T3794	det	the,distinction
R2269	T3794	T3791	nsubj	distinction,was
R2270	T3795	T3794	acl	observed,distinction
R2271	T3796	T3795	prep	in,observed
R2272	T3797	T3798	det	the,experiments
R2273	T3798	T3796	pobj	experiments,in
R2274	T3799	T3800	amod	osmotic,resistance
R2275	T3800	T3798	compound	resistance,experiments
R2276	T3801	T3802	advmod	highly,significant
R2277	T3802	T3791	acomp	significant,was
R2278	T3803	T3791	cc	and,was
R2279	T3804	T3791	conj	reflects,was
R2280	T3805	T3806	det	a,value
R2281	T3806	T3804	dobj	value,reflects
R2282	T3807	T3806	amod	mean,value
R2283	T3808	T3806	prep	over,value
R2284	T3809	T3810	det	a,number
R2285	T3810	T3808	pobj	number,over
R2286	T3811	T3810	amod	high,number
R2287	T3812	T3810	prep	of,number
R2288	T3813	T3814	amod	different,cells
R2289	T3814	T3812	pobj	cells,of
R2290	T3815	T3814	amod	red,cells
R2291	T3816	T3814	compound	blood,cells
R2292	T3817	T3791	punct	.,was
R2293	T3819	T3820	det	These,data
R2294	T3820	T3821	nsubj	data,suggest
R2295	T3822	T3823	mark	that,contributes
R2296	T3823	T3821	ccomp	contributes,suggest
R2297	T3824	T3825	compound	annexin,A7
R2298	T3825	T3823	nsubj	A7,contributes
R2299	T3826	T3823	prep	to,contributes
R2300	T3827	T3828	det	the,shape
R2301	T3828	T3826	pobj	shape,to
R2302	T3829	T3828	prep	of,shape
R2303	T3830	T3831	amod	red,cells
R2304	T3831	T3829	pobj	cells,of
R2305	T3832	T3831	compound	blood,cells
R2306	T3833	T3828	cc	and,shape
R2307	T3834	T3835	det	the,resistance
R2308	T3835	T3828	conj	resistance,shape
R2309	T3836	T3835	amod	osmotic,resistance
R2310	T3837	T3821	punct	.,suggest
R2311	T3839	T3840	mark	As,observed
R2312	T3840	T3844	advcl	observed,do
R2313	T3841	T3840	nsubj	we,observed
R2314	T3842	T3840	aux	have,observed
R2315	T3843	T3840	neg	not,observed
R2316	T3845	T3846	det	a,binding
R2317	T3846	T3840	dobj	binding,observed
R2318	T3847	T3846	prep	of,binding
R2319	T3848	T3849	compound	annexin,A7
R2320	T3849	T3847	pobj	A7,of
R2321	T3850	T3846	prep	to,binding
R2322	T3851	T3852	compound	F,actin
R2323	T3852	T3850	pobj	actin,to
R2324	T3853	T3852	punct	-,actin
R2325	T3854	T3855	punct	(,shown
R2326	T3855	T3840	parataxis	shown,observed
R2327	T3856	T3855	nsubj	data,shown
R2328	T3857	T3855	neg	not,shown
R2329	T3858	T3855	punct	),shown
R2330	T3859	T3844	nsubj	it,do
R2331	T3860	T3844	aux	could,do
R2332	T3861	T3844	advmod	so,do
R2333	T3862	T3863	preconj	either,by
R2334	T3863	T3844	prep	by,do
R2335	T3864	T3863	pobj	alteration,by
R2336	T3865	T3864	prep	of,alteration
R2337	T3866	T3867	det	the,rigidity
R2338	T3867	T3865	pobj	rigidity,of
R2339	T3868	T3867	compound	membrane,rigidity
R2340	T3869	T3863	cc	and,by
R2341	T3870	T3869	punct	/,and
R2342	T3871	T3869	cc	or,and
R2343	T3872	T3863	conj	by,by
R2344	T3873	T3872	pcomp	affecting,by
R2345	T3874	T3875	det	the,homeostasis
R2346	T3875	T3873	dobj	homeostasis,affecting
R2347	T3876	T3875	compound	ion,homeostasis
R2348	T3877	T3844	punct	.,do
R2349	T4078	T4079	det	The,lack
R2350	T4079	T4080	nsubj	lack,affects
R2351	T4081	T4079	prep	of,lack
R2352	T4082	T4083	compound	annexin,A7
R2353	T4083	T4081	pobj	A7,of
R2354	T4084	T4085	amod	primary,haemostasis
R2355	T4085	T4080	dobj	haemostasis,affects
R2356	T4086	T4087	advmod	ex,vivo
R2357	T4087	T4080	advmod	vivo,affects
R2358	T4089	T4090	det	The,use
R2359	T4090	T4091	nsubj	use,allowed
R2360	T4092	T4090	prep	of,use
R2361	T4093	T4094	det	an,counter
R2362	T4094	T4092	pobj	counter,of
R2363	T4095	T4094	amod	advanced,counter
R2364	T4096	T4094	amod	electronic,counter
R2365	T4097	T4094	compound	cell,counter
R2366	T4098	T4094	punct	/,counter
R2367	T4099	T4100	compound	flow,cytometer
R2368	T4100	T4094	appos	cytometer,counter
R2369	T4101	T4094	punct	(,counter
R2370	T4102	T4094	appos	ADVIA,counter
R2371	T4103	T4102	nummod	120,ADVIA
R2372	T4104	T4091	punct	),allowed
R2373	T4105	T4106	nsubj	us,screen
R2374	T4106	T4091	ccomp	screen,allowed
R2375	T4107	T4106	aux	to,screen
R2376	T4108	T4109	amod	other,parameters
R2377	T4109	T4106	dobj	parameters,screen
R2378	T4110	T4111	advmod	as,well
R2379	T4111	T4106	advmod	well,screen
R2380	T4112	T4106	prep	despite,screen
R2381	T4113	T4112	pcomp	of,despite
R2382	T4114	T4115	det	the,volume
R2383	T4115	T4112	pobj	volume,despite
R2384	T4116	T4115	amod	limited,volume
R2385	T4117	T4115	amod	murine,volume
R2386	T4118	T4115	compound	blood,volume
R2387	T4119	T4091	punct	.,allowed
R2388	T4121	T4122	nsubj	We,analysed
R2389	T4123	T4122	dobj	leukocytes,analysed
R2390	T4124	T4123	punct	", ",leukocytes
R2391	T4125	T4126	amod	red,cells
R2392	T4126	T4123	conj	cells,leukocytes
R2393	T4127	T4126	compound	blood,cells
R2394	T4128	T4126	punct	", ",cells
R2395	T4129	T4130	compound	haemoglobin,content
R2396	T4130	T4126	conj	content,cells
R2397	T4131	T4130	punct	", ",content
R2398	T4132	T4130	conj	haematocrit,content
R2399	T4133	T4132	punct	", ",haematocrit
R2400	T4134	T4135	amod	mean,volume
R2401	T4135	T4132	conj	volume,haematocrit
R2402	T4136	T4135	amod	cellular,volume
R2403	T4137	T4135	punct	", ",volume
R2404	T4138	T4139	amod	mean,haemoglobin
R2405	T4139	T4135	conj	haemoglobin,volume
R2406	T4140	T4139	amod	cellular,haemoglobin
R2407	T4141	T4139	punct	", ",haemoglobin
R2408	T4142	T4143	amod	mean,haemoglobin
R2409	T4143	T4145	compound	haemoglobin,concentration
R2410	T4144	T4143	amod	cellular,haemoglobin
R2411	T4145	T4139	conj	concentration,haemoglobin
R2412	T4146	T4145	punct	", ",concentration
R2413	T4147	T4145	conj	platelets,concentration
R2414	T4148	T4147	punct	", ",platelets
R2415	T4149	T4147	conj	neutrophiles,platelets
R2416	T4150	T4149	punct	", ",neutrophiles
R2417	T4151	T4149	conj	lymphocytes,neutrophiles
R2418	T4152	T4151	punct	", ",lymphocytes
R2419	T4153	T4151	conj	monocytes,lymphocytes
R2420	T4154	T4153	punct	", ",monocytes
R2421	T4155	T4153	conj	eosinophiles,monocytes
R2422	T4156	T4155	cc	and,eosinophiles
R2423	T4157	T4155	conj	basophiles,eosinophiles
R2424	T4158	T4122	punct	.,analysed
R2425	T4160	T4161	prep	In,found
R2426	T4162	T4163	det	these,tests
R2427	T4163	T4160	pobj	tests,In
R2428	T4164	T4163	prep	of,tests
R2429	T4165	T4166	amod	whole,blood
R2430	T4166	T4164	pobj	blood,of
R2431	T4167	T4161	nsubj	we,found
R2432	T4168	T4161	advmod	only,found
R2433	T4169	T4170	det	a,change
R2434	T4170	T4161	dobj	change,found
R2435	T4171	T4170	prep	in,change
R2436	T4172	T4173	det	the,numbers
R2437	T4173	T4171	pobj	numbers,in
R2438	T4174	T4173	compound	platelet,numbers
R2439	T4175	T4161	punct	", ",found
R2440	T4176	T4177	mark	whereas,affected
R2441	T4177	T4161	advcl	affected,found
R2442	T4178	T4179	det	all,parameters
R2443	T4179	T4177	nsubjpass	parameters,affected
R2444	T4180	T4179	amod	other,parameters
R2445	T4181	T4179	amod	haematological,parameters
R2446	T4182	T4177	auxpass	were,affected
R2447	T4183	T4177	neg	not,affected
R2448	T4184	T4161	punct	.,found
R2449	T4186	T4187	det	The,counts
R2450	T4187	T4190	nsubjpass	counts,determined
R2451	T4188	T4187	amod	mean,counts
R2452	T4189	T4187	compound	platelet,counts
R2453	T4191	T4187	prep	from,counts
R2454	T4192	T4193	amod	wild,type
R2455	T4193	T4194	nmod	type,mice
R2456	T4194	T4191	pobj	mice,from
R2457	T4195	T4193	cc	and,type
R2458	T4196	T4193	conj	anxA7,type
R2459	T4197	T4196	punct	-,anxA7
R2460	T4198	T4196	punct	/,anxA7
R2461	T4199	T4196	punct	-,anxA7
R2462	T4200	T4194	amod	mutant,mice
R2463	T4201	T4190	auxpass	are,determined
R2464	T4202	T4190	prep	as,determined
R2465	T4203	T4204	quantmod	674,103
R2466	T4204	T4202	pobj	103,as
R2467	T4205	T4204	punct	×,103
R2468	T4206	T4207	punct	/,μl
R2469	T4207	T4204	prep	μl,103
R2470	T4208	T4204	cc	and,103
R2471	T4209	T4210	quantmod	774,103
R2472	T4210	T4204	conj	103,103
R2473	T4211	T4210	punct	×,103
R2474	T4212	T4213	punct	/,μl
R2475	T4213	T4210	prep	μl,103
R2476	T4214	T4190	punct	", ",determined
R2477	T4215	T4190	advmod	respectively,determined
R2478	T4216	T4190	punct	.,determined
R2479	T4218	T4219	det	The,counts
R2480	T4219	T4221	nsubj	counts,are
R2481	T4220	T4219	compound	platelet,counts
R2482	T4222	T4219	prep	in,counts
R2483	T4223	T4224	compound	knock,out
R2484	T4224	T4225	compound	out,mice
R2485	T4225	T4222	pobj	mice,in
R2486	T4226	T4227	advmod	significantly,higher
R2487	T4227	T4221	acomp	higher,are
R2488	T4228	T4229	punct	(,14
R2489	T4229	T4227	parataxis	14,higher
R2490	T4230	T4231	nsubj	p,0.0275
R2491	T4231	T4229	ccomp	0.0275,14
R2492	T4232	T4231	punct	=,0.0275
R2493	T4233	T4229	punct	;,14
R2494	T4234	T4235	compound	n,out
R2495	T4235	T4237	nsubj	out,11
R2496	T4236	T4235	compound	knock,out
R2497	T4237	T4229	ccomp	11,14
R2498	T4238	T4237	punct	=,11
R2499	T4239	T4229	punct	", ",14
R2500	T4240	T4241	nmod	n,type
R2501	T4241	T4229	nsubj	type,14
R2502	T4242	T4241	amod	wild,type
R2503	T4243	T4229	punct	=,14
R2504	T4244	T4229	punct	),14
R2505	T4245	T4221	punct	.,are
R2506	T4247	T4248	det	An,increase
R2507	T4248	T4249	nsubj	increase,is
R2508	T4250	T4248	prep	in,increase
R2509	T4251	T4252	compound	platelet,counts
R2510	T4252	T4250	pobj	counts,in
R2511	T4253	T4254	det	a,disorder
R2512	T4254	T4249	attr	disorder,is
R2513	T4255	T4256	advmod	rather,uncommon
R2514	T4256	T4254	amod	uncommon,disorder
R2515	T4257	T4249	punct	.,is
R2516	T4259	T4260	prep	In,increase
R2517	T4261	T4259	pobj	humans,In
R2518	T4262	T4260	punct	", ",increase
R2519	T4263	T4264	compound	platelet,counts
R2520	T4264	T4260	nsubj	counts,increase
R2521	T4265	T4260	advmod	normally,increase
R2522	T4266	T4267	advmod	only,transiently
R2523	T4267	T4260	advmod	transiently,increase
R2524	T4268	T4260	prep	as,increase
R2525	T4269	T4268	pobj	in,as
R2526	T4270	T4271	amod	reactive,thrombocytosis
R2527	T4271	T4269	pobj	thrombocytosis,in
R2528	T4272	T4269	cc	and,in
R2529	T4273	T4269	conj	under,in
R2530	T4274	T4275	amod	postoperative,conditions
R2531	T4275	T4273	pobj	conditions,under
R2532	T4276	T4260	cc	or,increase
R2533	T4277	T4278	auxpass	are,increased
R2534	T4278	T4260	conj	increased,increase
R2535	T4279	T4278	advmod	largely,increased
R2536	T4280	T4278	prep	in,increased
R2537	T4281	T4282	amod	neoplastic,diseases
R2538	T4282	T4280	pobj	diseases,in
R2539	T4283	T4260	punct	.,increase
R2540	T4285	T4286	prep	By,are
R2541	T4287	T4285	pobj	contrast,By
R2542	T4288	T4286	punct	", ",are
R2543	T4289	T4290	det	the,mice
R2544	T4290	T4286	nsubj	mice,are
R2545	T4291	T4290	nmod	anxA7,mice
R2546	T4292	T4291	punct	-,anxA7
R2547	T4293	T4291	punct	/,anxA7
R2548	T4294	T4291	punct	-,anxA7
R2549	T4295	T4286	acomp	healthy,are
R2550	T4296	T4295	cc	and,healthy
R2551	T4297	T4295	conj	viable,healthy
R2552	T4298	T4286	punct	.,are
R2553	T4300	T4301	advmod	Therefore,tested
R2554	T4302	T4301	nsubj	we,tested
R2555	T4303	T4304	det	the,function
R2556	T4304	T4301	dobj	function,tested
R2557	T4305	T4304	compound	platelet,function
R2558	T4306	T4301	cc	and,tested
R2559	T4307	T4301	conj	performed,tested
R2560	T4308	T4309	compound	aggregometry,measurements
R2561	T4309	T4307	dobj	measurements,performed
R2562	T4310	T4307	prep	with,performed
R2563	T4311	T4312	npadvmod	platelet,rich
R2564	T4312	T4313	amod	rich,plasma
R2565	T4313	T4310	pobj	plasma,with
R2566	T4314	T4301	punct	.,tested
R2567	T4316	T4317	compound	Platelet,activation
R2568	T4317	T4318	nsubjpass	activation,observed
R2569	T4319	T4318	auxpass	is,observed
R2570	T4320	T4318	prep	as,observed
R2571	T4321	T4322	det	a,change
R2572	T4322	T4320	pobj	change,as
R2573	T4323	T4322	amod	morphological,change
R2574	T4324	T4322	prep	from,change
R2575	T4325	T4326	det	the,state
R2576	T4326	T4324	pobj	state,from
R2577	T4327	T4326	amod	resting,state
R2578	T4328	T4326	amod	discoid,state
R2579	T4329	T4322	prep	to,change
R2580	T4330	T4331	amod	activated,cells
R2581	T4331	T4329	pobj	cells,to
R2582	T4332	T4331	amod	spherical,cells
R2583	T4333	T4331	prep	with,cells
R2584	T4334	T4333	pobj	pseudopods,with
R2585	T4335	T4318	punct	.,observed
R2586	T4337	T4338	det	The,changes
R2587	T4338	T4340	nsubj	changes,are
R2588	T4339	T4338	amod	morphological,changes
R2589	T4341	T4340	prep	due,are
R2590	T4342	T4341	pcomp	to,due
R2591	T4343	T4344	amod	cytoskeletal,rearrangements
R2592	T4344	T4341	pobj	rearrangements,due
R2593	T4345	T4340	punct	.,are
R2594	T4347	T4348	advmod	In,vitro
R2595	T4348	T4349	advmod	vitro,form
R2596	T4350	T4351	det	the,cells
R2597	T4351	T4349	nsubj	cells,form
R2598	T4352	T4351	amod	activated,cells
R2599	T4353	T4349	dobj	aggregates,form
R2600	T4354	T4349	advcl	recruiting,form
R2601	T4355	T4356	amod	additional,cells
R2602	T4356	T4354	dobj	cells,recruiting
R2603	T4357	T4354	prep	in,recruiting
R2604	T4358	T4359	det	the,solution
R2605	T4359	T4357	pobj	solution,in
R2606	T4360	T4361	advmod	thereby,reducing
R2607	T4361	T4354	dep	reducing,recruiting
R2608	T4362	T4363	poss	its,cloudiness
R2609	T4363	T4361	dobj	cloudiness,reducing
R2610	T4364	T4349	punct	.,form
R2611	T4366	T4367	nsubj	Analysis,showed
R2612	T4368	T4366	prep	of,Analysis
R2613	T4369	T4370	det	the,values
R2614	T4370	T4368	pobj	values,of
R2615	T4371	T4370	compound	transmission,values
R2616	T4372	T4370	prep	of,values
R2617	T4373	T4374	compound	aggregation,curves
R2618	T4374	T4372	pobj	curves,of
R2619	T4375	T4366	prep	after,Analysis
R2620	T4376	T4377	compound	platelet,activation
R2621	T4377	T4375	pobj	activation,after
R2622	T4378	T4377	prep	by,activation
R2623	T4379	T4380	compound	ristocetin,addition
R2624	T4380	T4378	pobj	addition,by
R2625	T4381	T4382	punct	(,cofactor
R2626	T4382	T4380	parataxis	cofactor,addition
R2627	T4383	T4384	compound	von,Willebrand
R2628	T4384	T4382	compound	Willebrand,cofactor
R2629	T4385	T4382	punct	),cofactor
R2630	T4386	T4387	mark	that,differed
R2631	T4387	T4367	ccomp	differed,showed
R2632	T4388	T4389	det	both,curves
R2633	T4389	T4387	nsubj	curves,differed
R2634	T4390	T4387	advmod	significantly,differed
R2635	T4391	T4387	prep	at,differed
R2636	T4392	T4393	det	the,point
R2637	T4393	T4391	pobj	point,at
R2638	T4394	T4393	compound	time,point
R2639	T4395	T4393	prep	of,point
R2640	T4396	T4397	nummod	seven,seconds
R2641	T4397	T4395	pobj	seconds,of
R2642	T4398	T4397	prep	after,seconds
R2643	T4399	T4400	compound	platelet,initiation
R2644	T4400	T4398	pobj	initiation,after
R2645	T4401	T4402	punct	(,Fig.
R2646	T4402	T4387	parataxis	Fig.,differed
R2647	T4403	T4404	nsubj	p,0.0287
R2648	T4404	T4402	ccomp	0.0287,Fig.
R2649	T4405	T4404	punct	=,0.0287
R2650	T4406	T4402	punct	", ",Fig.
R2651	T4407	T4408	compound	n,out
R2652	T4408	T4410	nsubj	out,16
R2653	T4409	T4408	compound	knock,out
R2654	T4410	T4402	ccomp	16,Fig.
R2655	T4411	T4410	punct	=,16
R2656	T4412	T4402	punct	", ",Fig.
R2657	T4413	T4414	nmod	n,type
R2658	T4414	T4416	nsubj	type,15
R2659	T4415	T4414	amod	wild,type
R2660	T4416	T4402	ccomp	15,Fig.
R2661	T4417	T4416	punct	=,15
R2662	T4418	T4402	punct	;,Fig.
R2663	T4419	T4402	nummod	6,Fig.
R2664	T4420	T4402	punct	),Fig.
R2665	T4421	T4367	punct	.,showed
R2666	T4423	T4424	compound	Annexin,A7
R2667	T4424	T4425	npadvmod	A7,deficient
R2668	T4425	T4426	amod	deficient,platelets
R2669	T4426	T4427	nsubj	platelets,showed
R2670	T4428	T4429	det	a,velocity
R2671	T4429	T4427	dobj	velocity,showed
R2672	T4430	T4431	advmod	slightly,lowered
R2673	T4431	T4429	amod	lowered,velocity
R2674	T4432	T4429	compound	aggregation,velocity
R2675	T4433	T4427	punct	.,showed
R2676	T4435	T4436	advmod	When,compared
R2677	T4436	T4438	advcl	compared,found
R2678	T4437	T4436	nsubj	we,compared
R2679	T4439	T4440	det	the,curves
R2680	T4440	T4436	dobj	curves,compared
R2681	T4441	T4440	compound	aggregation,curves
R2682	T4442	T4440	prep	of,curves
R2683	T4443	T4444	amod	human,platelets
R2684	T4444	T4442	pobj	platelets,of
R2685	T4445	T4444	prep	from,platelets
R2686	T4446	T4447	det	a,donor
R2687	T4447	T4445	pobj	donor,from
R2688	T4448	T4447	amod	healthy,donor
R2689	T4449	T4436	prep	with,compared
R2690	T4450	T4451	det	the,ones
R2691	T4451	T4449	pobj	ones,with
R2692	T4452	T4451	acl	obtained,ones
R2693	T4453	T4452	prep	from,obtained
R2694	T4454	T4455	det	an,individual
R2695	T4455	T4453	pobj	individual,from
R2696	T4456	T4455	prep	with,individual
R2697	T4457	T4458	det	a,defect
R2698	T4458	T4456	pobj	defect,with
R2699	T4459	T4460	nmod	von,Willebrand
R2700	T4460	T4461	nmod	Willebrand,factor
R2701	T4461	T4458	nmod	factor,defect
R2702	T4462	T4458	nmod	type,defect
R2703	T4463	T4462	nummod	1,type
R2704	T4464	T4438	punct	", ",found
R2705	T4465	T4438	nsubj	we,found
R2706	T4466	T4467	mark	that,was
R2707	T4467	T4438	ccomp	was,found
R2708	T4468	T4469	det	the,difference
R2709	T4469	T4467	nsubj	difference,was
R2710	T4470	T4469	prep	in,difference
R2711	T4471	T4472	det	the,curves
R2712	T4472	T4470	pobj	curves,in
R2713	T4473	T4474	advmod	much,more
R2714	T4474	T4475	advmod	more,pronounced
R2715	T4475	T4467	acomp	pronounced,was
R2716	T4476	T4477	mark	as,observed
R2717	T4477	T4467	advcl	observed,was
R2718	T4478	T4477	prep	in,observed
R2719	T4479	T4480	poss	our,studies
R2720	T4480	T4478	pobj	studies,in
R2721	T4481	T4480	prep	of,studies
R2722	T4482	T4483	amod	healthy,platelets
R2723	T4483	T4481	pobj	platelets,of
R2724	T4484	T4483	compound	mouse,platelets
R2725	T4485	T4483	cc	and,platelets
R2726	T4486	T4487	nmod	anxA7,platelets
R2727	T4487	T4483	conj	platelets,platelets
R2728	T4488	T4486	punct	-,anxA7
R2729	T4489	T4486	punct	/,anxA7
R2730	T4490	T4486	punct	-,anxA7
R2731	T4491	T4438	punct	.,found
R2732	T4493	T4494	advmod	Furthermore,found
R2733	T4495	T4494	nsubj	we,found
R2734	T4496	T4497	mark	that,responded
R2735	T4497	T4494	ccomp	responded,found
R2736	T4498	T4499	amod	murine,platelets
R2737	T4499	T4497	nsubj	platelets,responded
R2738	T4500	T4497	advmod	immediately,responded
R2739	T4501	T4497	prep	to,responded
R2740	T4502	T4503	det	the,chemical
R2741	T4503	T4501	pobj	chemical,to
R2742	T4504	T4503	amod	initiating,chemical
R2743	T4505	T4506	mark	whereas,have
R2744	T4506	T4497	advcl	have,responded
R2745	T4507	T4508	amod	human,platelets
R2746	T4508	T4506	nsubj	platelets,have
R2747	T4509	T4510	det	a,phase
R2748	T4510	T4506	dobj	phase,have
R2749	T4511	T4510	compound	lag,phase
R2750	T4512	T4513	punct	[,23
R2751	T4513	T4494	parataxis	23,found
R2752	T4514	T4513	punct	],23
R2753	T4515	T4494	punct	.,found
R5713	T9090	T9089	prep	of,Expression
R5714	T9091	T9092	compound	annexin,A7
R5715	T9092	T9090	pobj	A7,of
R5716	T9093	T9089	prep	in,Expression
R5717	T9094	T9095	amod	human,cells
R5718	T9095	T9093	pobj	cells,in
R5719	T9096	T9095	amod	red,cells
R5720	T9097	T9095	compound	blood,cells
R5721	T9098	T9099	punct	(,1
R5722	T9099	T9095	parataxis	1,cells
R5723	T9100	T9099	punct	),1
R5724	T9101	T9095	cc	and,cells
R5725	T9102	T9103	amod	human,platelets
R5726	T9103	T9095	conj	platelets,cells
R5727	T9104	T9105	punct	(,2
R5728	T9105	T9103	parataxis	2,platelets
R5729	T9106	T9105	punct	),2
R5730	T9107	T9089	punct	.,Expression
R5731	T9109	T9110	compound	Protein,homogenates
R5732	T9110	T9111	nsubjpass	homogenates,separated
R5733	T9112	T9111	auxpass	were,separated
R5734	T9113	T9111	prep	by,separated
R5735	T9114	T9115	compound	SDS,PAGE
R5736	T9115	T9113	pobj	PAGE,by
R5737	T9116	T9115	punct	-,PAGE
R5738	T9117	T9118	punct	(,acrylamide
R5739	T9118	T9111	parataxis	acrylamide,separated
R5740	T9119	T9120	nummod	12,%
R5741	T9120	T9118	compound	%,acrylamide
R5742	T9121	T9118	punct	),acrylamide
R5743	T9122	T9111	punct	.,separated
R5744	T9124	T9125	det	The,blot
R5745	T9125	T9128	nsubjpass	blot,probed
R5746	T9126	T9125	amod	resulting,blot
R5747	T9127	T9125	amod	western,blot
R5748	T9128	T9130	ccomp	probed,was
R5749	T9129	T9128	auxpass	was,probed
R5750	T9131	T9128	prep	with,probed
R5751	T9132	T9131	pobj	mAb,with
R5752	T9133	T9132	nummod	203–217,mAb
R5753	T9134	T9130	punct	", ",was
R5754	T9135	T9130	nsubj	visualization,was
R5755	T9136	T9130	prep	by,was
R5756	T9137	T9138	det	a,antibody
R5757	T9138	T9136	pobj	antibody,by
R5758	T9139	T9138	amod	secondary,antibody
R5759	T9140	T9141	npadvmod	peroxidase,coupled
R5760	T9141	T9138	amod	coupled,antibody
R5761	T9142	T9138	acl	followed,antibody
R5762	T9143	T9142	agent	by,followed
R5763	T9144	T9143	pobj	ECL,by
R5764	T9145	T9130	punct	.,was
R5765	T9147	T9148	det	Both,isoforms
R5766	T9148	T9149	nsubjpass	isoforms,detected
R5767	T9149	T9151	ccomp	detected,is
R5768	T9150	T9149	auxpass	are,detected
R5769	T9152	T9149	prep	in,detected
R5770	T9153	T9154	amod	red,cells
R5771	T9154	T9152	pobj	cells,in
R5772	T9155	T9154	compound	blood,cells
R5773	T9156	T9151	punct	", ",is
R5774	T9157	T9151	prep	in,is
R5775	T9158	T9157	pobj	platelets,in
R5776	T9159	T9160	advmod	only,isoform
R5777	T9160	T9151	nsubj	isoform,is
R5778	T9161	T9160	det	the,isoform
R5779	T9162	T9160	amod	small,isoform
R5780	T9163	T9151	acomp	present,is
R5781	T9164	T9151	punct	.,is
R5782	T9241	T9240	prep	of,Enrichment
R5783	T9242	T9243	compound	annexin,A7
R5784	T9243	T9241	pobj	A7,of
R5785	T9244	T9243	cc	and,A7
R5786	T9245	T9243	conj	sorcin,A7
R5787	T9246	T9240	prep	in,Enrichment
R5788	T9247	T9246	pobj	exovesicles,in
R5789	T9248	T9247	acl	derived,exovesicles
R5790	T9249	T9248	prep	from,derived
R5791	T9250	T9251	amod	red,cells
R5792	T9251	T9249	pobj	cells,from
R5793	T9252	T9251	compound	blood,cells
R5794	T9253	T9240	punct	.,Enrichment
R5795	T9255	T9256	nsubjpass	Vesicles,generated
R5796	T9257	T9255	prep	from,Vesicles
R5797	T9258	T9259	amod	wild,type
R5798	T9259	T9257	pobj	type,from
R5799	T9260	T9259	punct	(,type
R5800	T9261	T9259	appos	wt,type
R5801	T9262	T9259	punct	),type
R5802	T9263	T9259	cc	and,type
R5803	T9264	T9265	nmod	anxA7,mutant
R5804	T9265	T9259	conj	mutant,type
R5805	T9266	T9264	punct	-,anxA7
R5806	T9267	T9264	punct	/,anxA7
R5807	T9268	T9264	punct	-,anxA7
R5808	T9269	T9265	punct	(,mutant
R5809	T9270	T9265	appos	ko,mutant
R5810	T9271	T9256	punct	),generated
R5811	T9272	T9256	auxpass	were,generated
R5812	T9273	T9256	prep	with,generated
R5813	T9274	T9275	compound	Ca2+,ionophore
R5814	T9275	T9277	compound	ionophore,treatment
R5815	T9276	T9275	punct	/,ionophore
R5816	T9277	T9273	pobj	treatment,with
R5817	T9278	T9256	punct	", ",generated
R5818	T9279	T9256	conj	isolated,generated
R5819	T9280	T9279	prep	by,isolated
R5820	T9281	T9282	amod	differential,centrifugation
R5821	T9282	T9280	pobj	centrifugation,by
R5822	T9283	T9279	cc	and,isolated
R5823	T9284	T9279	conj	analysed,isolated
R5824	T9285	T9284	prep	by,analysed
R5825	T9286	T9285	pobj	immunoblotting,by
R5826	T9287	T9284	prep	with,analysed
R5827	T9288	T9289	nmod	mAb,203
R5828	T9289	T9287	pobj	203,with
R5829	T9290	T9291	punct	–,217
R5830	T9291	T9289	prep	217,203
R5831	T9292	T9289	cc	and,203
R5832	T9293	T9294	det	a,antibody
R5833	T9294	T9289	conj	antibody,203
R5834	T9295	T9294	nmod	sorcin,antibody
R5835	T9296	T9294	amod	polyclonal,antibody
R5836	T9297	T9256	punct	.,generated
R5837	T9299	T9300	prep	In,are
R5838	T9301	T9299	amod	general,In
R5839	T9302	T9300	punct	", ",are
R5840	T9303	T9304	compound	annexin,A7
R5841	T9304	T9300	nsubj	A7,are
R5842	T9305	T9304	cc	and,A7
R5843	T9306	T9304	conj	sorcin,A7
R5844	T9307	T9308	advmod	more,abundant
R5845	T9308	T9300	acomp	abundant,are
R5846	T9309	T9300	prep	in,are
R5847	T9310	T9309	pobj	nanovesicles,in
R5848	T9311	T9300	punct	.,are
R5849	T9313	T9314	det	The,isoform
R5850	T9314	T9317	nsubjpass	isoform,observed
R5851	T9315	T9316	nummod	51,kDa
R5852	T9316	T9314	compound	kDa,isoform
R5853	T9318	T9314	prep	of,isoform
R5854	T9319	T9320	compound	annexin,A7
R5855	T9320	T9318	pobj	A7,of
R5856	T9321	T9322	punct	(,arrows
R5857	T9322	T9314	parataxis	arrows,isoform
R5858	T9323	T9322	punct	),arrows
R5859	T9324	T9317	auxpass	is,observed
R5860	T9325	T9317	advmod	only,observed
R5861	T9326	T9317	prep	in,observed
R5862	T9327	T9326	pobj	nanovesicles,in
R5863	T9328	T9317	punct	.,observed
R5864	T9330	T9331	nsubjpass	Samples,normalized
R5865	T9332	T9330	prep	of,Samples
R5866	T9333	T9334	det	both,types
R5867	T9334	T9332	pobj	types,of
R5868	T9335	T9334	compound	vesicles,types
R5869	T9336	T9331	auxpass	were,normalized
R5870	T9337	T9331	prep	according,normalized
R5871	T9338	T9337	prep	to,according
R5872	T9339	T9340	poss	their,activity
R5873	T9340	T9338	pobj	activity,to
R5874	T9341	T9342	compound	acetylcholine,esterase
R5875	T9342	T9340	compound	esterase,activity
R5876	T9343	T9331	punct	.,normalized
R5877	T9345	T9346	amod	Human,cells
R5878	T9346	T9349	nsubjpass	cells,used
R5879	T9347	T9346	amod	red,cells
R5880	T9348	T9346	compound	blood,cells
R5881	T9350	T9351	punct	(,co
R5882	T9351	T9346	parataxis	co,cells
R5883	T9352	T9351	punct	),co
R5884	T9353	T9349	auxpass	were,used
R5885	T9354	T9349	prep	for,used
R5886	T9355	T9354	pobj	control,for
R5887	T9356	T9349	cc	and,used
R5888	T9357	T9349	conj	normalized,used
R5889	T9358	T9357	advmod	independently,normalized
R5890	T9359	T9349	punct	.,used
R5891	T9398	T9397	prep	of,Association
R5892	T9399	T9400	compound	annexin,A7
R5893	T9400	T9398	pobj	A7,of
R5894	T9401	T9400	cc	and,A7
R5895	T9402	T9400	conj	sorcin,A7
R5896	T9403	T9397	prep	with,Association
R5897	T9404	T9405	amod	distinct,fractions
R5898	T9405	T9403	pobj	fractions,with
R5899	T9406	T9407	amod	red,cell
R5900	T9407	T9405	compound	cell,fractions
R5901	T9408	T9407	compound	blood,cell
R5902	T9409	T9410	compound	plasma,membrane
R5903	T9410	T9405	compound	membrane,fractions
R5904	T9411	T9397	punct	.,Association
R5905	T9413	T9414	amod	Lysed,cells
R5906	T9414	T9418	nsubjpass	cells,added
R5907	T9415	T9414	amod	human,cells
R5908	T9416	T9414	amod	red,cells
R5909	T9417	T9414	compound	blood,cells
R5910	T9419	T9418	auxpass	were,added
R5911	T9420	T9418	prep	to,added
R5912	T9421	T9422	det	a,gradient
R5913	T9422	T9420	pobj	gradient,to
R5914	T9423	T9424	npadvmod	self,forming
R5915	T9424	T9422	amod	forming,gradient
R5916	T9425	T9422	compound	iodixanol,gradient
R5917	T9426	T9422	compound	density,gradient
R5918	T9427	T9418	punct	.,added
R5919	T9429	T9430	det	The,density
R5920	T9430	T9431	nsubj	density,increases
R5921	T9432	T9430	prep	of,density
R5922	T9433	T9434	det	the,gradient
R5923	T9434	T9432	pobj	gradient,of
R5924	T9435	T9431	prep	from,increases
R5925	T9436	T9435	pobj	left,from
R5926	T9437	T9438	punct	(,g
R5927	T9438	T9436	parataxis	g,left
R5928	T9439	T9438	nummod	1.06,g
R5929	T9440	T9441	punct	/,ml
R5930	T9441	T9438	prep	ml,g
R5931	T9442	T9438	punct	),g
R5932	T9443	T9435	prep	to,from
R5933	T9444	T9443	pobj	right,to
R5934	T9445	T9446	punct	(,g
R5935	T9446	T9444	parataxis	g,right
R5936	T9447	T9446	nummod	1.20,g
R5937	T9448	T9449	punct	/,ml
R5938	T9449	T9446	prep	ml,g
R5939	T9450	T9446	punct	),g
R5940	T9451	T9431	punct	.,increases
R5941	T9453	T9454	nsubjpass	Fractions,analysed
R5942	T9455	T9454	auxpass	were,analysed
R5943	T9456	T9454	prep	by,analysed
R5944	T9457	T9456	pobj	immunoblotting,by
R5945	T9458	T9454	advcl	using,analysed
R5946	T9459	T9460	nmod	mAb,203
R5947	T9460	T9458	dobj	203,using
R5948	T9461	T9462	punct	–,217
R5949	T9462	T9460	prep	217,203
R5950	T9463	T9460	cc	and,203
R5951	T9464	T9465	det	the,antibody
R5952	T9465	T9460	conj	antibody,203
R5953	T9466	T9465	nmod	sorcin,antibody
R5954	T9467	T9465	amod	polyclonal,antibody
R5955	T9468	T9454	punct	.,analysed
R5959	T9493	T9494	amod	red,cells
R5960	T9494	T9492	pobj	cells,of
R5961	T9495	T9494	compound	blood,cells
R5962	T9496	T9494	prep	from,cells
R5963	T9497	T9498	nmod	anxA7,mutant
R5964	T9498	T9502	nmod	mutant,mice
R5965	T9499	T9497	punct	-,anxA7
R5966	T9500	T9497	punct	/,anxA7
R5967	T9501	T9497	punct	-,anxA7
R5968	T9502	T9496	pobj	mice,from
R5969	T9503	T9504	punct	(,B
R5970	T9504	T9498	parataxis	B,mutant
R5971	T9505	T9504	punct	),B
R5972	T9506	T9498	cc	and,mutant
R5973	T9507	T9508	amod	wild,type
R5974	T9508	T9498	conj	type,mutant
R5975	T9509	T9510	punct	(,A
R5976	T9510	T9502	parataxis	A,mice
R5977	T9511	T9510	punct	),A
R5978	T9512	T9491	punct	.,microscopy
R5979	T9514	T9515	det	The,diameters
R5980	T9515	T9518	nsubj	diameters,are
R5981	T9516	T9515	amod	mean,diameters
R5982	T9517	T9515	amod	cellular,diameters
R5983	T9519	T9520	nummod	6.0,μm
R5984	T9520	T9518	attr	μm,are
R5985	T9521	T9520	cc	and,μm
R5986	T9522	T9523	nummod	5.7,μm
R5987	T9523	T9520	conj	μm,μm
R5988	T9524	T9518	punct	", ",are
R5989	T9525	T9518	advmod	respectively,are
R5992	T9529	T9531	nsubj	differences,are
R5994	T9532	T9533	advmod	statistically,significant
R5995	T9533	T9531	acomp	significant,are
R5996	T9534	T9535	punct	(,40
R5997	T9535	T9531	parataxis	40,are
R5998	T9536	T9537	nsubj	p,0.015
R5999	T9537	T9535	ccomp	0.015,40
R6000	T9538	T9537	punct	=,0.015
R6001	T9539	T9535	punct	;,40
R6002	T9540	T9535	nsubj	n,40
R6003	T9541	T9535	punct	=,40
R6004	T9542	T9535	punct	),40
R6005	T9543	T9531	punct	.,are
R6006	T9545	T9546	dep	Bar,μm
R6007	T9547	T9546	punct	", ",μm
R6008	T9548	T9546	nummod	3,μm
R6009	T9549	T9546	punct	.,μm
R6014	T9617	T9618	amod	Osmotic,resistance
R6015	T9618	T9619	compound	resistance,curves
R6016	T9620	T9619	prep	of,curves
R6017	T9621	T9622	amod	red,cells
R6018	T9622	T9620	pobj	cells,of
R6019	T9623	T9622	compound	blood,cells
R6020	T9624	T9619	prep	from,curves
R6021	T9625	T9626	amod	wild,type
R6022	T9626	T9627	nmod	type,mice
R6023	T9627	T9624	pobj	mice,from
R6024	T9628	T9626	cc	and,type
R6025	T9629	T9626	conj	anxA7,type
R6026	T9630	T9629	punct	-,anxA7
R6027	T9631	T9629	punct	/,anxA7
R6028	T9632	T9629	punct	-,anxA7
R6029	T9633	T9627	amod	mutant,mice
R6030	T9634	T9619	punct	.,curves
R6031	T9636	T9637	det	The,resistance
R6032	T9637	T9639	nsubj	resistance,is
R6033	T9638	T9637	amod	osmotic,resistance
R6034	T9640	T9637	prep	towards,resistance
R6035	T9641	T9640	pobj	changes,towards
R6036	T9642	T9641	prep	in,changes
R6037	T9643	T9644	det	the,strength
R6038	T9644	T9642	pobj	strength,in
R6039	T9645	T9644	amod	extracellular,strength
R6040	T9646	T9644	amod	ionic,strength
R6041	T9647	T9648	det	a,assay
R6042	T9648	T9639	attr	assay,is
R6043	T9649	T9648	amod	convenient,assay
R6044	T9650	T9648	prep	for,assay
R6045	T9651	T9650	pobj	analysis,for
R6046	T9652	T9651	prep	of,analysis
R6047	T9653	T9654	det	the,integrity
R6048	T9654	T9652	pobj	integrity,of
R6049	T9655	T9656	amod	red,cell
R6050	T9656	T9654	compound	cell,integrity
R6051	T9657	T9656	compound	blood,cell
R6052	T9658	T9639	punct	.,is
R6053	T9660	T9661	nsubjpass	It,measured
R6054	T9662	T9661	auxpass	is,measured
R6055	T9663	T9661	prep	as,measured
R6056	T9664	T9665	det	a,concentration
R6057	T9665	T9663	pobj	concentration,as
R6058	T9666	T9667	compound	sodium,chloride
R6059	T9667	T9665	compound	chloride,concentration
R6060	T9668	T9669	prep	in,starts
R6061	T9669	T9665	relcl	starts,concentration
R6062	T9670	T9668	pobj	which,in
R6063	T9671	T9672	amod	cellular,lysis
R6064	T9672	T9669	nsubj	lysis,starts
R6065	T9673	T9674	punct	(,resistance
R6066	T9674	T9665	parataxis	resistance,concentration
R6067	T9675	T9674	amod	minimal,resistance
R6068	T9676	T9674	punct	),resistance
R6069	T9677	T9665	prep	up,concentration
R6070	T9678	T9677	prep	to,up
R6071	T9679	T9680	det	a,lysis
R6072	T9680	T9678	pobj	lysis,to
R6073	T9681	T9680	amod	complete,lysis
R6074	T9682	T9683	punct	(,resistance
R6075	T9683	T9680	parataxis	resistance,lysis
R6076	T9684	T9683	amod	maximal,resistance
R6077	T9685	T9683	punct	),resistance
R6078	T9686	T9680	prep	of,lysis
R6079	T9687	T9688	det	a,cell
R6080	T9688	T9686	pobj	cell,of
R6081	T9689	T9688	amod	red,cell
R6082	T9690	T9688	compound	blood,cell
R6083	T9691	T9661	punct	.,measured
R6084	T9693	T9694	det	The,resistance
R6085	T9694	T9696	nsubj	resistance,is
R6086	T9695	T9694	amod	osmotic,resistance
R6087	T9697	T9694	prep	of,resistance
R6088	T9698	T9699	compound	annexin,A7
R6089	T9699	T9700	npadvmod	A7,deficient
R6090	T9700	T9701	amod	deficient,cells
R6091	T9701	T9697	pobj	cells,of
R6092	T9702	T9701	amod	red,cells
R6093	T9703	T9701	compound	blood,cells
R6094	T9704	T9705	advmod	significantly,increased
R6095	T9705	T9696	acomp	increased,is
R6096	T9706	T9696	prep	compared,is
R6097	T9707	T9706	prep	to,compared
R6098	T9708	T9709	det	the,one
R6099	T9709	T9707	pobj	one,to
R6100	T9710	T9709	prep	of,one
R6101	T9711	T9712	amod	wild,type
R6102	T9712	T9710	pobj	type,of
R6103	T9713	T9714	punct	(,8
R6104	T9714	T9696	parataxis	8,is
R6105	T9715	T9716	nsubj	p,0.00066
R6106	T9716	T9714	ccomp	0.00066,8
R6107	T9717	T9716	punct	=,0.00066
R6108	T9718	T9714	punct	;,8
R6109	T9719	T9714	nsubj	n,8
R6110	T9720	T9714	punct	=,8
R6111	T9721	T9714	punct	),8
R6112	T9722	T9696	punct	.,is
R6113	T9783	T9784	compound	Platelet,aggregation
R6114	T9784	T9785	compound	aggregation,curves
R6115	T9786	T9785	prep	from,curves
R6116	T9787	T9788	npadvmod	platelet,rich
R6117	T9788	T9789	amod	rich,plasma
R6118	T9789	T9786	pobj	plasma,from
R6119	T9790	T9789	prep	of,plasma
R6120	T9791	T9792	nmod	annexin,A7
R6121	T9792	T9793	nmod	A7,mice
R6122	T9793	T9790	pobj	mice,of
R6123	T9794	T9795	compound	knock,out
R6124	T9795	T9792	appos	out,A7
R6125	T9796	T9795	cc	and,out
R6126	T9797	T9798	amod	wild,type
R6127	T9798	T9795	conj	type,out
R6128	T9799	T9785	punct	.,curves
R6129	T9801	T9802	det	The,values
R6130	T9802	T9804	nsubjpass	values,measured
R6131	T9803	T9802	compound	transmission,values
R6132	T9805	T9804	auxpass	were,measured
R6133	T9806	T9804	prep	with,measured
R6134	T9807	T9808	det	an,photometer
R6135	T9808	T9806	pobj	photometer,with
R6136	T9809	T9808	compound	APACT,photometer
R6137	T9810	T9804	cc	and,measured
R6138	T9811	T9812	nsubjpass	aggregation,initiated
R6139	T9812	T9804	conj	initiated,measured
R6140	T9813	T9812	auxpass	was,initiated
R6141	T9814	T9812	prep	by,initiated
R6142	T9815	T9814	pcomp	adding,by
R6143	T9816	T9815	dobj	ristocetin,adding
R6144	T9817	T9812	punct	.,initiated
R6145	T9819	T9820	det	The,seconds
R6146	T9820	T9823	nsubjpass	seconds,given
R6147	T9821	T9820	amod	first,seconds
R6148	T9822	T9820	nummod	thirty,seconds
R6149	T9824	T9823	auxpass	are,given
R6150	T9825	T9823	punct	.,given
R6151	T9827	T9828	amod	Constant,counts
R6152	T9828	T9830	nsubjpass	counts,used
R6153	T9829	T9828	compound	platelet,counts
R6154	T9831	T9830	auxpass	were,used
R6155	T9832	T9830	prep	throughout,used
R6156	T9833	T9834	det	all,experiments
R6157	T9834	T9832	pobj	experiments,throughout
R6158	T9835	T9830	punct	.,used
R6159	T9837	T9838	det	The,data
R6160	T9838	T9841	nsubjpass	data,analysed
R6161	T9839	T9840	compound	aggregation,curve
R6162	T9840	T9838	compound	curve,data
R6163	T9841	T9843	ccomp	analysed,set
R6164	T9842	T9841	auxpass	were,analysed
R6165	T9844	T9841	prep	for,analysed
R6166	T9845	T9846	compound	slope,values
R6167	T9846	T9844	pobj	values,for
R6168	T9847	T9843	punct	", ",set
R6169	T9848	T9849	det	the,amplitude
R6170	T9849	T9843	nsubjpass	amplitude,set
R6171	T9850	T9849	amod	maximal,amplitude
R6172	T9851	T9849	compound	aggregation,amplitude
R6173	T9852	T9849	prep	of,amplitude
R6174	T9853	T9854	det	every,curve
R6175	T9854	T9852	pobj	curve,of
R6176	T9855	T9854	amod	single,curve
R6177	T9856	T9843	auxpass	was,set
R6178	T9857	T9843	prep	to,set
R6179	T9858	T9859	nummod	100,%
R6180	T9859	T9857	pobj	%,to
R6181	T9860	T9843	punct	.,set
R6182	T9862	T9863	det	Both,curves
R6183	T9863	T9865	nsubj	curves,differ
R6184	T9864	T9863	amod	murine,curves
R6185	T9865	T9866	ccomp	differ,shows
R6186	T9867	T9865	advmod	significantly,differ
R6187	T9868	T9865	prep	at,differ
R6188	T9869	T9870	det	a,point
R6189	T9870	T9868	pobj	point,at
R6190	T9871	T9870	compound	time,point
R6191	T9872	T9870	prep	of,point
R6192	T9873	T9874	nummod	seven,seconds
R6193	T9874	T9872	pobj	seconds,of
R6194	T9875	T9874	prep	after,seconds
R6195	T9876	T9877	compound	platelet,initiation
R6196	T9877	T9875	pobj	initiation,after
R6197	T9878	T9866	punct	", ",shows
R6198	T9879	T9880	det	the,mutant
R6199	T9880	T9866	nsubj	mutant,shows
R6200	T9881	T9882	det	a,velocity
R6201	T9882	T9866	dobj	velocity,shows
R6202	T9883	T9884	advmod	slightly,lower
R6203	T9884	T9882	amod	lower,velocity
R6204	T9885	T9882	compound	aggregation,velocity
R6205	T9886	T9887	punct	(,transmission
R6206	T9887	T9882	parataxis	transmission,velocity
R6207	T9888	T9889	nsubj	p,0.0287
R6208	T9889	T9887	ccomp	0.0287,transmission
R6209	T9890	T9889	punct	=,0.0287
R6210	T9891	T9887	punct	", ",transmission
R6211	T9892	T9893	compound	n,out
R6212	T9893	T9895	nsubj	out,16
R6213	T9894	T9893	compound	knock,out
R6214	T9895	T9887	ccomp	16,transmission
R6215	T9896	T9895	punct	=,16
R6216	T9897	T9887	punct	", ",transmission
R6217	T9898	T9899	nmod	n,type
R6218	T9899	T9901	nsubj	type,15
R6219	T9900	T9899	amod	wild,type
R6220	T9901	T9887	ccomp	15,transmission
R6221	T9902	T9901	punct	=,15
R6222	T9903	T9887	punct	", ",transmission
R6223	T9904	T9905	amod	mean,out
R6224	T9905	T9907	nsubj	out,transmission
R6225	T9906	T9905	compound	knock,out
R6226	T9907	T9887	ccomp	transmission,transmission
R6227	T9908	T9907	punct	=,transmission
R6228	T9909	T9910	nummod	67.7,%
R6229	T9910	T9907	compound	%,transmission
R6230	T9911	T9887	punct	", ",transmission
R6231	T9912	T9913	amod	mean,type
R6232	T9913	T9915	nsubj	type,transmission
R6233	T9914	T9913	amod	wild,type
R6234	T9915	T9887	ccomp	transmission,transmission
R6235	T9916	T9915	punct	=,transmission
R6236	T9917	T9918	nummod	77.1,%
R6237	T9918	T9915	compound	%,transmission
R6238	T9919	T9887	punct	", ",transmission
R6239	T9920	T9921	amod	standard,error
R6240	T9921	T9922	compound	error,out
R6241	T9922	T9924	nsubj	out,transmission
R6242	T9923	T9922	compound	knock,out
R6243	T9924	T9887	ccomp	transmission,transmission
R6244	T9925	T9924	punct	=,transmission
R6245	T9926	T9927	nummod	8.3,%
R6246	T9927	T9924	compound	%,transmission
R6247	T9928	T9887	punct	", ",transmission
R6248	T9929	T9930	amod	standard,error
R6249	T9930	T9931	nmod	error,type
R6250	T9931	T9887	nsubj	type,transmission
R6251	T9932	T9931	amod	wild,type
R6252	T9933	T9887	punct	=,transmission
R6253	T9934	T9935	nummod	13.8,%
R6254	T9935	T9887	compound	%,transmission
R6255	T9936	T9887	punct	),transmission
R6256	T9937	T9866	punct	.,shows
R6257	T9939	T9940	amod	Murine,platelets
R6258	T9940	T9941	nsubj	platelets,react
R6259	T9942	T9941	advmod	immediately,react
R6260	T9943	T9941	prep	to,react
R6261	T9944	T9945	det	the,chemical
R6262	T9945	T9943	pobj	chemical,to
R6263	T9946	T9945	amod	initiating,chemical
R6264	T9947	T9941	cc	and,react
R6265	T9948	T9941	conj	show,react
R6266	T9949	T9950	det	no,phase
R6267	T9950	T9948	dobj	phase,show
R6268	T9951	T9950	compound	lag,phase
R6269	T9952	T9948	prep	like,show
R6270	T9953	T9954	det	the,platelets
R6271	T9954	T9952	pobj	platelets,like
R6272	T9955	T9954	amod	normal,platelets
R6273	T9956	T9954	amod	human,platelets
R6274	T9957	T9941	punct	.,react
R6275	T9959	T9960	prep	For,shown
R6276	T9961	T9959	pobj	comparison,For
R6277	T9962	T9961	prep	of,comparison
R6278	T9963	T9964	det	the,range
R6279	T9964	T9962	pobj	range,of
R6280	T9965	T9964	prep	of,range
R6281	T9966	T9967	det	the,impairment
R6282	T9967	T9965	pobj	impairment,of
R6283	T9968	T9967	compound	platelet,impairment
R6284	T9969	T9970	advmod	slightly,affected
R6285	T9970	T9971	amod	affected,platelets
R6286	T9971	T9960	nsubjpass	platelets,shown
R6287	T9972	T9971	amod	human,platelets
R6288	T9973	T9960	auxpass	are,shown
R6289	T9974	T9975	advmod	as,well
R6290	T9975	T9960	advmod	well,shown
R6291	T9976	T9977	punct	(,syndrome
R6292	T9977	T9960	parataxis	syndrome,shown
R6293	T9978	T9979	compound	von,Willebrand
R6294	T9979	T9977	compound	Willebrand,syndrome
R6295	T9980	T9977	punct	),syndrome
R6296	T9981	T9960	punct	.,shown
R1408	T2601	T2599	pobj	suggestion,to
R1409	T2602	T2601	punct	", ",suggestion
R1410	T2603	T2604	mark	that,plays
R1411	T2604	T2601	acl	plays,suggestion
R1412	T2605	T2604	punct	", ",plays
R1413	T2606	T2604	prep	along,plays
R1414	T2607	T2606	prep	with,along
R1415	T2608	T2609	compound	raft,domains
R1416	T2609	T2607	pobj	domains,with
R1417	T2610	T2604	punct	", ",plays
R1418	T2611	T2612	compound	annexin,A7
R1419	T2612	T2604	nsubj	A7,plays
R1582	T2787	T2773	prep	for,both
R1583	T2788	T2787	pobj	wt,for
R1584	T2789	T2788	cc	and,wt
R1585	T2790	T2788	conj	ko,wt
R1586	T2791	T2773	punct	),both
R1587	T2792	T2748	punct	.,differ
R1588	T2794	T2795	nsubj	It,appears
R1589	T2796	T2797	mark	that,is
R1590	T2797	T2795	ccomp	is,appears
R1591	T2798	T2799	compound	annexin,A7
R1592	T2799	T2797	nsubj	A7,is
R1593	T2800	T2797	punct	", ",is
R1594	T2801	T2802	mark	although,described
R1595	T2802	T2797	advcl	described,is
R1649	T2859	T2860	aux	To,study
R1650	T2860	T2861	advcl	study,used
R1651	T2862	T2863	det	the,distribution
R1652	T2863	T2860	dobj	distribution,study
R1653	T2864	T2863	prep	of,distribution
R1654	T2865	T2866	compound	annexin,A7
R1655	T2866	T2864	pobj	A7,of
R1656	T2867	T2860	prep	in,study
R1657	T2868	T2869	amod	red,cells
R1658	T2869	T2867	pobj	cells,in
R1659	T2870	T2869	compound	blood,cells
R1660	T2871	T2861	nsubj	we,used
R1661	T2872	T2873	npadvmod	self,forming
R1662	T2873	T2874	amod	forming,gradients
R1663	T2874	T2861	dobj	gradients,used
R1881	T3373	T3371	dobj	diameter,had
R1882	T3374	T3375	advmod	statistically,significant
R1883	T3375	T3373	amod	significant,diameter
R1884	T3376	T3373	amod	larger,diameter
R1885	T3377	T3373	compound	cell,diameter
R1886	T3378	T3373	prep	of,diameter
R1887	T3379	T3380	nummod	6.0,μm
R1888	T3380	T3378	pobj	μm,of
R1889	T3381	T3373	prep	compared,diameter
R1890	T3382	T3381	prep	to,compared
R1891	T3383	T3384	amod	wild,type
R1892	T3384	T3382	pobj	type,to
R1893	T3385	T3384	prep	with,type
R1894	T3386	T3387	nummod	5.7,μm
R1895	T3387	T3385	pobj	μm,with
R1896	T3388	T3389	punct	(,40
R5956	T9489	T9490	amod	Dark,field
R5957	T9490	T9491	compound	field,microscopy
R5958	T9492	T9491	prep	of,microscopy
R5990	T9526	T9518	punct	.,are
R5991	T9528	T9529	det	The,differences
R5993	T9530	T9529	compound	size,differences
R1328	T2512	T2513	det	these,findings
R1329	T2513	T2509	dobj	findings,extended
R1330	T2514	T2509	cc	and,extended
R1331	T2515	T2509	conj	show,extended
R1332	T2516	T2515	advmod	here,show
R1333	T2517	T2518	mark	that,is
R1334	T2518	T2515	ccomp	is,show
R1402	T2594	T2595	poss	Its,presence
R1403	T2595	T2596	nsubj	presence,led
R1404	T2597	T2595	prep	in,presence
R1405	T2598	T2597	pobj	vesicles,in
R1406	T2599	T2596	prep	to,led
R1407	T2600	T2601	det	the,suggestion
R1897	T3389	T3373	parataxis	40,diameter
R1898	T3390	T3391	nsubj	p,0.015
R1899	T3391	T3389	ccomp	0.015,40
R1900	T3392	T3391	punct	=,0.015
R1901	T3393	T3389	punct	", ",40
R1941	T3437	T3438	nsubj	Shape,influence
R1942	T3439	T3437	cc	and,Shape
R1943	T3440	T3437	conj	MCV,Shape
R1944	T3441	T3437	prep	of,Shape
R1945	T3442	T3443	det	a,cell
R1946	T3443	T3441	pobj	cell,of
R1947	T3444	T3443	amod	red,cell
R1948	T3445	T3443	compound	blood,cell
R1949	T3446	T3438	advmod	essentially,influence
R1950	T3447	T3448	poss	its,function
R1951	T3448	T3438	dobj	function,influence
R1952	T3449	T3448	cc	and,function
R1953	T3450	T3451	amod	capillary,passage
R1954	T3451	T3448	conj	passage,function
R1955	T3452	T3438	punct	.,influence
R1956	T3454	T3455	det	The,form
R1957	T3455	T3458	nsubj	form,depends
R1958	T3456	T3455	amod	typical,form
R1959	T3457	T3455	compound	biconcave,form
R1960	T3459	T3458	prep	on,depends
R1961	T3460	T3461	amod	various,influences
R1962	T3461	T3459	pobj	influences,on
R1963	T3462	T3461	prep	including,influences
R1964	T3463	T3464	det	the,composition
R1965	T3464	T3462	pobj	composition,including
R1966	T3465	T3466	compound	membrane,lipid
R1967	T3466	T3464	compound	lipid,composition
R1968	T3467	T3464	cc	and,composition
R1969	T3468	T3469	det	the,cytoskeleton
R1970	T3469	T3464	conj	cytoskeleton,composition
R1971	T3470	T3469	amod	submembranous,cytoskeleton
R1972	T3471	T3472	punct	[,32
R1973	T3472	T3469	parataxis	32,cytoskeleton
R1974	T3473	T3472	punct	],32
R2231	T3752	T3753	poss	their,morphology
R2232	T3753	T3751	pobj	morphology,with
R2233	T3754	T3738	punct	.,tried
R2234	T3756	T3757	nsubj	We,observe
R2235	T3758	T3757	aux	could,observe
R2236	T3759	T3757	neg	not,observe
R2237	T3760	T3761	det	any,difference
R2238	T3761	T3757	dobj	difference,observe
R2239	T3762	T3763	advmod	statistically,significant
R2240	T3763	T3761	amod	significant,difference
R2241	T3764	T3761	prep	of,difference
R2242	T3765	T3764	pobj	values,of
R2243	T3766	T3765	acl	describing,values
R2244	T3767	T3768	compound	membrane,rigidity
R2245	T3768	T3766	dobj	rigidity,describing
R2246	T3769	T3768	cc	and,rigidity
R2247	T3770	T3771	compound	lysis,force
R2248	T3771	T3768	conj	force,rigidity
R2249	T3772	T3757	prep	in,observe

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T2247	9-19	PR:000004080	denotes	Annexin A7
T2248	20-30	GO:0010467	denotes	expression
T2249	34-49	CL:0000232	denotes	red blood cells
T2250	38-43	UBERON:0000178	denotes	blood
T2251	51-65	CL:0000232	denotes	red blood cell
T2252	55-60	UBERON:0000178	denotes	blood
T2253	74-85	GO:0070382	denotes	exovesicles
T2254	93-102	CL:0000233	denotes	platelets
T2255	162-169	SO:0001060	denotes	isoform
T2256	173-183	PR:000004080	denotes	annexin A7
T2257	200-206	PR:000015619	denotes	sorcin
T2258	210-216	_FRAGMENT	denotes	micro-
T2259	225-233	GO:1990742	denotes	vesicles
T2260	247-262	CL:0000232	denotes	red blood cells
T2261	251-256	UBERON:0000178	denotes	blood
T2262	324-338	GO:0045121	denotes	membrane rafts
T2263	410-417	SO:0001060	denotes	isoform
T2264	458-463	NCBITaxon:9606	denotes	human
T2265	464-479	CL:0000232	denotes	red blood cells
T2266	468-473	UBERON:0000178	denotes	blood
T2267	498-506	SO:0001060	denotes	isoforms
T2269	626-636	PR:000004080	denotes	annexin A7
T2270	707-714	SO:0001060	denotes	isoform
T2271	1151-1159	GO:0031982	denotes	vesicles
T2272	1200-1212	GO:0045121	denotes	raft domains
T2273	1214-1224	PR:000004080	denotes	annexin A7
T2274	1241-1249	GO:0016020	denotes	membrane
T2275	1271-1283	GO:0006900	denotes	vesiculation
T2276	1337-1352	CL:0000232	denotes	red blood cells
T2277	1341-1346	UBERON:0000178	denotes	blood
T2278	1370-1380	PR:000004080	denotes	annexin A7
T2279	1391-1395	NCBITaxon:10088	denotes	mice
T2280	1397-1402	PR:000004080	denotes	anxA7
T2282	1551-1556	NCBITaxon:9606	denotes	human
T2283	1557-1562	UBERON:0000178	denotes	blood
T2286	1633-1639	_FRAGMENT	denotes	micro-
T2287	1648-1656	GO:1990742	denotes	vesicles
T2288	1678-1682	CHEBI:29108	denotes	Ca2+
T2289	1683-1692	CHEBI:24869	denotes	ionophore
T2290	1720-1733	CHEBI:15355	denotes	acetylcholine
T2291	1781-1791	PR:000004080	denotes	Annexin A7
T2292	1811-1818	GO:0031982	denotes	vesicle
T2293	1858-1866	GO:0031982	denotes	vesicles
T2294	1888-1895	SO:0001060	denotes	isoform
T2295	1922-1930	GO:0031982	denotes	vesicles
T2296	1953-1960	GO:0031982	denotes	vesicle
T2297	2014-2028	CL:0000232	denotes	red blood cell
T2298	2018-2023	UBERON:0000178	denotes	blood
T2299	2029-2037	GO:0031982	denotes	vesicles
T2300	2081-2089	GO:0031982	denotes	vesicles
T2301	2103-2116	GO:1990742	denotes	microvesicles
T2302	2162-2172	PR:000004080	denotes	annexin A7
T2303	2213-2222	GO:0016020	denotes	membranes
T2304	2282-2296	CL:0000232	denotes	red blood cell
T2305	2286-2291	UBERON:0000178	denotes	blood
T2306	2297-2308	GO:0070382	denotes	exovesicles
T2307	2345-2351	PR:000015619	denotes	sorcin
T2308	2376-2384	GO:0031982	denotes	vesicles
T2309	2403-2409	PR:000015619	denotes	sorcin
T2310	2448-2456	GO:0031982	denotes	vesicles
T2311	3132-3142	PR:000004080	denotes	annexin A7
T2312	3146-3161	CL:0000232	denotes	red blood cells
T2313	3150-3155	UBERON:0000178	denotes	blood
T2314	3183-3192	CHEBI:31705	denotes	iodixanol
T2315	3217-3225	SO:0001060	denotes	isoforms
T2316	3345-3354	GO:0016020	denotes	membranes
T2317	3362-3371	GO:0016020	denotes	membranes
T2318	3388-3404	GO:0005886	denotes	plasma membranes
T2319	3408-3423	CL:0000232	denotes	red blood cells
T2320	3412-3417	UBERON:0000178	denotes	blood
T2321	3440-3450	GO:0043226	denotes	organelles
T2322	3556-3566	PR:000004080	denotes	annexin A7
T2323	3570-3589	GO:0044425	denotes	membrane subdomains
T2324	3610-3615	CHEBI:18059	denotes	lipid
T2325	3619-3624	CHEBI:18059	denotes	lipid
T2326	3690-3696	PR:000015619	denotes	sorcin
T2327	3787-3795	GO:0031982	denotes	vesicles
T2328	3826-3836	PR:000004080	denotes	annexin A7
T2329	3862-3871	CL:0000233	denotes	platelets
T2330	3876-3886	PR:000004080	denotes	annexin A7
T2331	3887-3897	GO:0010467	denotes	expression
T2332	3922-3929	SO:0001060	denotes	isoform
T3103	4319-4329	PR:000004080	denotes	annexin A7
T3104	4338-4352	CL:0000232	denotes	red blood cell
T3105	4342-4347	UBERON:0000178	denotes	blood
T3106	4390-4400	PR:000004080	denotes	annexin A7
T3107	4419-4433	CL:0000232	denotes	red blood cell
T3108	4423-4428	UBERON:0000178	denotes	blood
T3109	4434-4442	GO:0031982	denotes	vesicles
T3110	4505-4510	PR:000004080	denotes	anxA7
T3111	4513-4518	NCBITaxon:10088	denotes	mouse
T3112	4523-4537	CL:0000232	denotes	red blood cell
T3113	4527-4532	UBERON:0000178	denotes	blood
T3114	4588-4593	UBERON:0000178	denotes	blood
T3115	4721-4726	PR:000004080	denotes	anxA7
T3116	4729-4744	CL:0000232	denotes	red blood cells
T3117	4733-4738	UBERON:0000178	denotes	blood
T3118	5322-5336	CL:0000232	denotes	red blood cell
T3119	5326-5331	UBERON:0000178	denotes	blood
T3120	5376-5385	UBERON:0001982	denotes	capillary
T3121	5466-5474	GO:0016020	denotes	membrane
T3122	5475-5480	CHEBI:18059	denotes	lipid
T3123	5504-5514	GO:0016020	denotes	membranous
T3124	5515-5527	GO:0005856	denotes	cytoskeleton
T3125	5539-5549	PR:000004080	denotes	annexin A7
T3126	5640-5653	GO:0005576	denotes	extracellular
T3127	5654-5659	CHEBI:24870	denotes	ionic
T3128	5712-5726	CL:0000232	denotes	red blood cell
T3129	5716-5721	UBERON:0000178	denotes	blood
T3130	5760-5775	CHEBI:26710	denotes	sodium chloride
T3131	5799-5813	GO:0019835	denotes	cellular lysis
T3132	5859-5864	_FRAGMENT	denotes	lysis
T3133	5886-5888	_FRAGMENT	denotes	of
T3134	5893-5898	GO:0019835	denotes	cells
T3135	5958-5965	GO:0009986	denotes	surface
T3136	5994-6013	GO:0044237	denotes	cellular metabolism
T3137	6030-6043	GO:0005622	denotes	intracellular
T3138	6044-6047	CHEBI:24870	denotes	ion
T3139	6061-6076	CL:0000232	denotes	red blood cells
T3140	6065-6070	UBERON:0000178	denotes	blood
T3141	6169-6184	CL:0000232	denotes	red blood cells
T3142	6173-6178	UBERON:0000178	denotes	blood
T3143	6198-6206	GO:0016020	denotes	membrane
T3144	6247-6257	PR:000004080	denotes	annexin A7
T3145	6268-6283	CL:0000232	denotes	red blood cells
T3146	6272-6277	UBERON:0000178	denotes	blood
T3147	6412-6416	CHEBI:26710	denotes	NaCl
T3148	6417-6425	CHEBI:75958	denotes	solution
T3149	6500-6504	CHEBI:26710	denotes	NaCl
T3150	6505-6513	CHEBI:75958	denotes	solution
T3151	6543-6547	CHEBI:26710	denotes	NaCl
T3152	6699-6703	CHEBI:26710	denotes	NaCl
T3153	6704-6712	CHEBI:75958	denotes	solution
T3154	6760-6774	CL:0000232	denotes	red blood cell
T3155	6764-6769	UBERON:0000178	denotes	blood
T3156	6770-6783	GO:0005886	denotes	cell membrane
T3157	6842-6852	PR:000004080	denotes	annexin A7
T3158	6860-6868	GO:0016020	denotes	membrane
T3159	6966-6981	CL:0000232	denotes	red blood cells
T3160	6970-6975	UBERON:0000178	denotes	blood
T3161	7088-7096	GO:0016020	denotes	membrane
T3162	7110-7115	GO:0019835	denotes	lysis
T3163	7355-7370	CL:0000232	denotes	red blood cells
T3164	7359-7364	UBERON:0000178	denotes	blood
T3165	7947-7957	PR:000004080	denotes	annexin A7
T3166	7986-8001	CL:0000232	denotes	red blood cells
T3167	7990-7995	UBERON:0000178	denotes	blood
T3168	8067-8077	PR:000004080	denotes	annexin A7
T3169	8081-8088	GO:0031941	denotes	F-actin
T3170	8149-8157	GO:0016020	denotes	membrane
T3171	8191-8194	CHEBI:24870	denotes	ion
T3172	8191-8206	GO:0050801	denotes	ion homeostasis
T3948	8221-8231	PR:000004080	denotes	annexin A7
T3949	8248-8259	GO:0007599	denotes	haemostasis
T3950	8411-8417	NCBITaxon:39107	denotes	murine
T3952	8444-8454	CL:0000738	denotes	leukocytes
T3953	8456-8471	CL:0000232	denotes	red blood cells
T3954	8460-8465	UBERON:0000178	denotes	blood
T3955	8597-8606	CL:0000233	denotes	platelets
T3956	8608-8620	CL:0000775	denotes	neutrophiles
T3957	8622-8633	CL:0000542	denotes	lymphocytes
T3958	8635-8644	CL:0000576	denotes	monocytes
T3960	8663-8673	CL:0000767	denotes	basophiles
T3961	8699-8704	UBERON:0000178	denotes	blood
T3962	8735-8743	CL:0000233	denotes	platelet
T3963	8771-8785	UBERON:0000178	denotes	haematological
T3964	8825-8833	CL:0000233	denotes	platelet
T3965	8860-8865	PR:000004080	denotes	anxA7
T3966	8876-8880	NCBITaxon:10088	denotes	mice
T3967	8948-8956	CL:0000233	denotes	platelet
T3968	8977-8981	NCBITaxon:10088	denotes	mice
T3969	9072-9080	CL:0000233	denotes	platelet
T3970	9122-9128	NCBITaxon:9606	denotes	humans
T3971	9130-9138	CL:0000233	denotes	platelet
T3972	9312-9317	PR:000004080	denotes	anxA7
T3973	9373-9381	CL:0000233	denotes	platelet
T3974	9436-9444	CL:0000233	denotes	platelet
T3975	9450-9456	UBERON:0001969	denotes	plasma
T3976	9458-9466	CL:0000233	denotes	Platelet
T3977	9458-9477	GO:0030168	denotes	Platelet activation
T3978	9581-9591	GO:0031143	denotes	pseudopods
T3979	9630-9642	GO:0005856	denotes	cytoskeletal
T3980	9739-9747	CHEBI:75958	denotes	solution
T3981	9845-9853	CL:0000233	denotes	platelet
T3982	9845-9864	GO:0030168	denotes	platelet activation
T3983	9868-9878	CHEBI:85129	denotes	ristocetin
T3984	9904-9912	CHEBI:23357	denotes	cofactor
T3985	10002-10010	CL:0000233	denotes	platelet
T3986	10002-10021	GO:0030168	denotes	platelet initiation
T3987	10080-10090	PR:000004080	denotes	Annexin A7
T3988	10101-10110	CL:0000233	denotes	platelets
T3989	10202-10207	NCBITaxon:9606	denotes	human
T3990	10208-10217	CL:0000233	denotes	platelets
T3991	10270-10280	NCBITaxon:1	denotes	individual
T3992	10288-10309	PR:000017364	denotes	von Willebrand factor
T3993	10431-10436	NCBITaxon:10088	denotes	mouse
T3994	10437-10446	CL:0000233	denotes	platelets
T3995	10451-10456	PR:000004080	denotes	anxA7
T3996	10459-10468	CL:0000233	denotes	platelets
T3997	10496-10502	NCBITaxon:39107	denotes	murine
T3998	10503-10512	CL:0000233	denotes	platelets
T3999	10570-10575	NCBITaxon:9606	denotes	human
T4000	10576-10585	CL:0000233	denotes	platelets
T9053	761-771	GO:0010467	denotes	Expression
T9054	775-785	PR:000004080	denotes	annexin A7
T9055	789-794	NCBITaxon:9606	denotes	human
T9056	795-810	CL:0000232	denotes	red blood cells
T9057	799-804	UBERON:0000178	denotes	blood
T9058	819-824	NCBITaxon:9606	denotes	human
T9059	825-834	CL:0000233	denotes	platelets
T9060	878-881	CHEBI:8984	denotes	SDS
T9061	893-903	CHEBI:28619	denotes	acrylamide
T9062	1006-1013	MOP:0000779	denotes	coupled
T9063	1014-1022	GO:0042571	denotes	antibody
T9064	1045-1053	SO:0001060	denotes	isoforms
T9065	1070-1085	CL:0000232	denotes	red blood cells
T9066	1074-1079	UBERON:0000178	denotes	blood
T9067	1090-1099	CL:0000233	denotes	platelets
T9068	1115-1122	SO:0001060	denotes	isoform
T9188	2491-2501	PR:000004080	denotes	annexin A7
T9189	2506-2512	PR:000015619	denotes	sorcin
T9190	2516-2527	GO:0070382	denotes	exovesicles
T9191	2541-2556	CL:0000232	denotes	red blood cells
T9192	2545-2550	UBERON:0000178	denotes	blood
T9193	2558-2566	GO:0031982	denotes	Vesicles
T9194	2591-2596	PR:000004080	denotes	anxA7
T9195	2632-2636	CHEBI:29108	denotes	Ca2+
T9196	2637-2646	CHEBI:24869	denotes	ionophore
T9197	2752-2758	PR:000015619	denotes	sorcin
T9198	2770-2778	GO:0042571	denotes	antibody
T9199	2792-2802	PR:000004080	denotes	annexin A7
T9200	2807-2813	PR:000015619	denotes	sorcin
T9201	2839-2847	GO:0031982	denotes	vesicles
T9202	2860-2867	SO:0001060	denotes	isoform
T9203	2871-2881	PR:000004080	denotes	annexin A7
T9204	2915-2923	GO:0031982	denotes	vesicles
T9205	2941-2949	GO:0031982	denotes	vesicles
T9206	2991-3004	CHEBI:15355	denotes	acetylcholine
T9207	3024-3029	NCBITaxon:9606	denotes	Human
T9208	3030-3045	CL:0000232	denotes	red blood cells
T9209	3034-3039	UBERON:0000178	denotes	blood
T9371	3965-3975	PR:000004080	denotes	annexin A7
T9372	3980-3986	PR:000015619	denotes	sorcin
T9373	4001-4015	CL:0000232	denotes	red blood cell
T9374	4005-4010	UBERON:0000178	denotes	blood
T9375	4016-4031	GO:0005886	denotes	plasma membrane
T9376	4043-4048	GO:0019835	denotes	Lysed
T9377	4049-4054	NCBITaxon:9606	denotes	human
T9378	4055-4070	CL:0000232	denotes	red blood cells
T9379	4059-4064	UBERON:0000178	denotes	blood
T9380	4100-4109	CHEBI:31705	denotes	iodixanol
T9381	4278-4284	PR:000015619	denotes	sorcin
T9382	4296-4304	GO:0042571	denotes	antibody
T9475	5090-5105	CL:0000232	denotes	red blood cells
T9476	5094-5099	UBERON:0000178	denotes	blood
T9477	5111-5116	PR:000004080	denotes	anxA7
T9478	5145-5149	NCBITaxon:10088	denotes	mice
T9570	7411-7426	CL:0000232	denotes	red blood cells
T9571	7415-7420	UBERON:0000178	denotes	blood
T9572	7446-7451	PR:000004080	denotes	anxA7
T9573	7462-7466	NCBITaxon:10088	denotes	mice
T9574	7514-7527	GO:0005576	denotes	extracellular
T9575	7528-7533	CHEBI:24870	denotes	ionic
T9576	7585-7599	CL:0000232	denotes	red blood cell
T9577	7589-7594	UBERON:0000178	denotes	blood
T9578	7631-7646	CHEBI:26710	denotes	sodium chloride
T9579	7670-7684	GO:0019835	denotes	cellular lysis
T9580	7730-7735	_FRAGMENT	denotes	lysis
T9581	7757-7759	_FRAGMENT	denotes	of
T9582	7772-7776	GO:0019835	denotes	cell
T9583	7762-7776	CL:0000232	denotes	red blood cell
T9584	7766-7771	UBERON:0000178	denotes	blood
T9585	7804-7814	PR:000004080	denotes	annexin A7
T9586	7825-7840	CL:0000232	denotes	red blood cells
T9587	7829-7834	UBERON:0000178	denotes	blood
T9740	10619-10627	CL:0000233	denotes	Platelet
T9741	10619-10639	GO:0070527	denotes	Platelet aggregation
T9742	10652-10660	CL:0000233	denotes	platelet
T9743	10666-10672	UBERON:0001969	denotes	plasma
T9744	10676-10686	PR:000004080	denotes	annexin A7
T9745	10711-10715	NCBITaxon:10088	denotes	mice
T9746	10820-10830	CHEBI:85129	denotes	ristocetin
T9747	10877-10885	CL:0000233	denotes	platelet
T9748	11069-11075	NCBITaxon:39107	denotes	murine
T9749	11143-11151	CL:0000233	denotes	platelet
T9750	11143-11162	GO:0030168	denotes	platelet initiation
T9751	11440-11446	NCBITaxon:39107	denotes	Murine
T9752	11447-11456	CL:0000233	denotes	platelets
T9753	11540-11545	NCBITaxon:9606	denotes	human
T9754	11546-11555	CL:0000233	denotes	platelets
T9755	11592-11600	CL:0000233	denotes	platelet
T9756	11630-11635	NCBITaxon:9606	denotes	human
T9757	11636-11645	CL:0000233	denotes	platelets
T3951	8418-8423	UBERON:0000178	denotes	blood
T3959	8646-8658	CL:0000771	denotes	eosinophiles
T2268	560-567	SO:0001060	denotes	isoform
T2281	1415-1426	GO:0070382	denotes	exovesicles
T2284	1595-1605	PR:000004080	denotes	annexin A7
T2285	1620-1631	GO:0070382	denotes	exovesicles
R6010	T9581	T9580	_lexicallyChainedTo	of,lysis
R6011	T9582	T9581	_lexicallyChainedTo	cell,of
R1260	T2259	T2258	_lexicallyChainedTo	vesicles,micro-
R1261	T2287	T2286	_lexicallyChainedTo	vesicles,micro-
R1791	T3133	T3132	_lexicallyChainedTo	of,lysis
R1792	T3134	T3133	_lexicallyChainedTo	cells,of

2_test

Id	Subject	Object	Predicate	Lexical cue
12925238-11895795-8102397	340-341	11895795	denotes	7
12925238-11895795-8102398	3676-3677	11895795	denotes	7
12925238-11798399-8102399	10604-10606	11798399	denotes	23

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T2333	9-19	PR_EXT:000004080	denotes	Annexin A7
T2334	20-30	GO:0010467	denotes	expression
T2335	34-49	CL:0000232	denotes	red blood cells
T2336	38-43	UBERON:0000178	denotes	blood
T2337	44-49	CL_GO_EXT:cell	denotes	cells
T2338	51-65	CL:0000232	denotes	red blood cell
T2339	55-60	UBERON:0000178	denotes	blood
T2340	61-65	CL_GO_EXT:cell	denotes	cell
T2341	74-85	GO:0070382	denotes	exovesicles
T2342	93-102	CL:0000233	denotes	platelets
T2343	162-169	SO_EXT:0001060	denotes	isoform
T2344	173-183	PR_EXT:000004080	denotes	annexin A7
T2345	200-206	PR_EXT:000015619	denotes	sorcin
T2346	210-216	_FRAGMENT	denotes	micro-
T2347	225-233	GO:1990742	denotes	vesicles
T2348	247-262	CL:0000232	denotes	red blood cells
T2349	251-256	UBERON:0000178	denotes	blood
T2350	257-262	CL_GO_EXT:cell	denotes	cells
T2351	293-298	GO_UBERON_EXT:lumen	denotes	lumen
T2352	324-338	GO:0045121	denotes	membrane rafts
T2353	410-417	SO_EXT:0001060	denotes	isoform
T2354	458-463	NCBITaxon:9606	denotes	human
T2355	464-479	CL:0000232	denotes	red blood cells
T2356	468-473	UBERON:0000178	denotes	blood
T2357	474-479	CL_GO_EXT:cell	denotes	cells
T2358	498-506	SO_EXT:0001060	denotes	isoforms
T2359	560-567	SO_EXT:0001060	denotes	isoform
T2360	584-590	CHEBI_EXT:silver	denotes	silver
T2361	626-636	PR_EXT:000004080	denotes	annexin A7
T2395	1990-1999	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T2397	2018-2023	UBERON:0000178	denotes	blood
T2398	2024-2028	CL_GO_EXT:cell	denotes	cell
T2399	2029-2037	GO:0031982	denotes	vesicles
T2400	2059-2063	GO_PR_EXT:acetylcholinesterase	denotes	AChE
T2401	2081-2089	GO:0031982	denotes	vesicles
T2402	2103-2116	GO:1990742	denotes	microvesicles
T2403	2134-2136	SO_EXT:wild_type_entity	denotes	wt
T2404	2162-2172	PR_EXT:000004080	denotes	annexin A7
T2405	2213-2222	GO:0016020	denotes	membranes
T2406	2282-2296	CL:0000232	denotes	red blood cell
T2407	2286-2291	UBERON:0000178	denotes	blood
T2408	2292-2296	CL_GO_EXT:cell	denotes	cell
T2409	2297-2308	GO:0070382	denotes	exovesicles
T2410	2345-2351	PR_EXT:000015619	denotes	sorcin
T2411	2355-2364	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T2412	2369-2375	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T2413	2376-2384	GO:0031982	denotes	vesicles
T2414	2403-2409	PR_EXT:000015619	denotes	sorcin
T2415	2437-2443	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T2416	2448-2456	GO:0031982	denotes	vesicles
T3175	4342-4347	UBERON:0000178	denotes	blood
T3176	4348-4352	CL_GO_EXT:cell	denotes	cell
T3177	4390-4400	PR_EXT:000004080	denotes	annexin A7
T3178	4419-4433	CL:0000232	denotes	red blood cell
T3179	4423-4428	UBERON:0000178	denotes	blood
T3180	4429-4433	CL_GO_EXT:cell	denotes	cell
T3181	4434-4442	GO:0031982	denotes	vesicles
T3182	4490-4497	CHEBI_PR_EXT:protein	denotes	protein
T3183	4505-4510	PR_EXT:000004080	denotes	anxA7
T3184	4510-4511	SO_EXT:sequence_nullness_or_absence	denotes	-
T3185	4512-4513	SO_EXT:sequence_nullness_or_absence	denotes	-
T3186	4513-4518	NCBITaxon:10088	denotes	mouse
T3187	4523-4537	CL:0000232	denotes	red blood cell
T3188	4527-4532	UBERON:0000178	denotes	blood
T3189	4533-4537	CL_GO_EXT:cell	denotes	cell
T3190	4588-4593	UBERON:0000178	denotes	blood
T3191	4638-4643	CL_GO_EXT:cell	denotes	cells
T3192	4721-4726	PR_EXT:000004080	denotes	anxA7
T3193	4726-4727	SO_EXT:sequence_nullness_or_absence	denotes	-
T3194	4728-4729	SO_EXT:sequence_nullness_or_absence	denotes	-
T3195	4729-4744	CL:0000232	denotes	red blood cells
T3196	4733-4738	UBERON:0000178	denotes	blood
T3197	4739-4744	CL_GO_EXT:cell	denotes	cells
T3198	4790-4794	CL_GO_EXT:cell	denotes	cell
T3199	4826-4835	SO_EXT:wild_type_entity	denotes	wild type
T3200	5041-5045	CL_GO_EXT:cell	denotes	cell
T3201	5322-5336	CL:0000232	denotes	red blood cell
T3202	5326-5331	UBERON:0000178	denotes	blood
T3203	5332-5336	CL_GO_EXT:cell	denotes	cell
T3204	5376-5385	UBERON:0001982	denotes	capillary
T3205	5386-5393	GO_EXT:biological_movement_or_translocation_process	denotes	passage
T3206	5466-5474	GO:0016020	denotes	membrane
T3207	5475-5480	CHEBI:18059	denotes	lipid
T3238	6247-6257	PR_EXT:000004080	denotes	annexin A7
T3239	6268-6283	CL:0000232	denotes	red blood cells
T3240	6272-6277	UBERON:0000178	denotes	blood
T3241	6278-6283	CL_GO_EXT:cell	denotes	cells
T3242	6323-6332	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T3243	6333-6338	CL_GO_EXT:cell	denotes	cells
T3244	6382-6387	CL_GO_EXT:cell	denotes	cells
T3245	6412-6416	CHEBI:26710	denotes	NaCl
T3246	6417-6425	CHEBI:75958	denotes	solution
T3247	6444-6453	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T3248	6454-6459	CL_GO_EXT:cell	denotes	cells
T3249	6500-6504	CHEBI:26710	denotes	NaCl
T3250	6505-6513	CHEBI:75958	denotes	solution
T3251	6543-6547	CHEBI:26710	denotes	NaCl
T3252	6552-6561	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T3253	6562-6567	CL_GO_EXT:cell	denotes	cells
T3254	6649-6654	CL_GO_EXT:cell	denotes	cells
T3255	6699-6703	CHEBI:26710	denotes	NaCl
T3256	6704-6712	CHEBI:75958	denotes	solution
T3257	6760-6774	CL:0000232	denotes	red blood cell
T3258	6764-6769	UBERON:0000178	denotes	blood
T3259	6770-6783	GO:0005886	denotes	cell membrane
T3260	6842-6852	PR_EXT:000004080	denotes	annexin A7
T3261	6860-6868	GO:0016020	denotes	membrane
T3262	6966-6981	CL:0000232	denotes	red blood cells
T3263	6970-6975	UBERON:0000178	denotes	blood
T3264	6976-6981	CL_GO_EXT:cell	denotes	cells
T3265	7088-7096	GO:0016020	denotes	membrane
T3266	7110-7115	GO:0019835	denotes	lysis
T3267	7355-7370	CL:0000232	denotes	red blood cells
T3268	7359-7364	UBERON:0000178	denotes	blood
T3269	7365-7370	CL_GO_EXT:cell	denotes	cells
T3270	7947-7957	PR_EXT:000004080	denotes	annexin A7
T3271	7986-8001	CL:0000232	denotes	red blood cells
T3272	7990-7995	UBERON:0000178	denotes	blood
T3273	7996-8001	CL_GO_EXT:cell	denotes	cells
T3274	8056-8063	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T3275	8067-8077	PR_EXT:000004080	denotes	annexin A7
T3276	8081-8088	GO:0031941	denotes	F-actin
T3277	8149-8157	GO:0016020	denotes	membrane
T3278	8191-8194	CHEBI:24870	denotes	ion
T3279	8191-8206	GO:0050801	denotes	ion homeostasis
T4001	8221-8231	PR_EXT:000004080	denotes	annexin A7
T4002	8248-8259	GO:0007599	denotes	haemostasis
T4003	8302-8306	CL_GO_EXT:cell	denotes	cell
T4004	8411-8417	NCBITaxon:39107	denotes	murine
T4005	8418-8423	UBERON:0000178	denotes	blood
T4006	8444-8454	CL:0000738	denotes	leukocytes
T4007	8456-8471	CL:0000232	denotes	red blood cells
T4008	8460-8465	UBERON:0000178	denotes	blood
T4009	8466-8471	CL_GO_EXT:cell	denotes	cells
T4010	8473-8484	CHEBI_GO_EXT:hemoglobin	denotes	haemoglobin
T4011	8512-8520	CL_GO_EXT:cell	denotes	cellular
T4012	8534-8542	CL_GO_EXT:cell	denotes	cellular
T4013	8543-8554	CHEBI_GO_EXT:hemoglobin	denotes	haemoglobin
T4014	8561-8569	CL_GO_EXT:cell	denotes	cellular
T4015	8570-8581	CHEBI_GO_EXT:hemoglobin	denotes	haemoglobin
T4016	8597-8606	CL:0000233	denotes	platelets
T4017	8608-8620	CL:0000775	denotes	neutrophiles
T4018	8622-8633	CL:0000542	denotes	lymphocytes
T4019	8635-8644	CL:0000576	denotes	monocytes
T4020	8646-8658	CL:0000771	denotes	eosinophiles
T4021	8663-8673	CL:0000767	denotes	basophiles
T4022	8699-8704	UBERON:0000178	denotes	blood
T4023	8735-8743	CL:0000233	denotes	platelet
T4024	8771-8785	UBERON:0000178	denotes	haematological
T4025	8825-8833	CL:0000233	denotes	platelet
T4026	8846-8855	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T4027	8860-8865	PR_EXT:000004080	denotes	anxA7
T4028	8865-8866	SO_EXT:sequence_nullness_or_absence	denotes	-
T4029	8867-8868	SO_EXT:sequence_nullness_or_absence	denotes	-
T4030	8869-8875	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4031	8876-8880	NCBITaxon:10088	denotes	mice
T4032	8948-8956	CL:0000233	denotes	platelet
T4033	8977-8981	NCBITaxon:10088	denotes	mice
T4034	9040-9049	SO_EXT:wild_type_entity	denotes	wild type
T4035	9072-9080	CL:0000233	denotes	platelet
T4036	9122-9128	NCBITaxon:9606	denotes	humans
T4037	9130-9138	CL:0000233	denotes	platelet
T4038	9312-9317	PR_EXT:000004080	denotes	anxA7
T4039	9317-9318	SO_EXT:sequence_nullness_or_absence	denotes	-
T4040	9319-9320	SO_EXT:sequence_nullness_or_absence	denotes	-
T4041	9373-9381	CL:0000233	denotes	platelet
T4042	9436-9444	CL:0000233	denotes	platelet
T4043	9450-9456	UBERON:0001969	denotes	plasma
T4044	9458-9466	CL:0000233	denotes	Platelet
T4045	9458-9477	GO:0030168	denotes	Platelet activation
T4046	9570-9575	CL_GO_EXT:cell	denotes	cells
T4047	9581-9591	GO:0031143	denotes	pseudopods
T4048	9630-9642	GO:0005856	denotes	cytoskeletal
T4049	9682-9687	CL_GO_EXT:cell	denotes	cells
T4050	9704-9714	GO_EXT:biological_recruitment	denotes	recruiting
T4051	9726-9731	CL_GO_EXT:cell	denotes	cells
T4052	9739-9747	CHEBI:75958	denotes	solution
T4053	9845-9853	CL:0000233	denotes	platelet
T4054	9845-9864	GO:0030168	denotes	platelet activation
T4055	9868-9878	CHEBI:85129	denotes	ristocetin
T4056	9904-9912	CHEBI_EXT:23357	denotes	cofactor
T4057	10002-10010	CL:0000233	denotes	platelet
T4058	10002-10021	GO:0030168	denotes	platelet initiation
T4059	10055-10064	SO_EXT:wild_type_entity	denotes	wild type
T4060	10080-10090	PR_EXT:000004080	denotes	Annexin A7
T4061	10101-10110	CL:0000233	denotes	platelets
T4062	10202-10207	NCBITaxon:9606	denotes	human
T4063	10208-10217	CL:0000233	denotes	platelets
T4064	10270-10280	NCBITaxon:1	denotes	individual
T4065	10288-10309	PR_EXT:000017364	denotes	von Willebrand factor
T4066	10431-10436	NCBITaxon:10088	denotes	mouse
T4067	10437-10446	CL:0000233	denotes	platelets
T4068	10451-10456	PR_EXT:000004080	denotes	anxA7
T4069	10456-10457	SO_EXT:sequence_nullness_or_absence	denotes	-
T4070	10458-10459	SO_EXT:sequence_nullness_or_absence	denotes	-
T4071	10459-10468	CL:0000233	denotes	platelets
T4072	10496-10502	NCBITaxon:39107	denotes	murine
T4073	10503-10512	CL:0000233	denotes	platelets
T4074	10513-10522	GO_EXT:reaction_or_response	denotes	responded
T4075	10553-10561	CHEBI_EXT:chemical_substance_or_polyatomic_entity	denotes	chemical
T4076	10570-10575	NCBITaxon:9606	denotes	human
T4077	10576-10585	CL:0000233	denotes	platelets
T9086	1080-1085	CL_GO_EXT:cell	denotes	cells
T9087	1090-1099	CL:0000233	denotes	platelets
T9088	1115-1122	SO_EXT:0001060	denotes	isoform
T9210	2491-2501	PR_EXT:000004080	denotes	annexin A7
T9211	2506-2512	PR_EXT:000015619	denotes	sorcin
T9212	2516-2527	GO:0070382	denotes	exovesicles
T9213	2541-2556	CL:0000232	denotes	red blood cells
T9214	2545-2550	UBERON:0000178	denotes	blood
T9215	2551-2556	CL_GO_EXT:cell	denotes	cells
T9216	2558-2566	GO:0031982	denotes	Vesicles
T9217	2572-2581	SO_EXT:wild_type_entity	denotes	wild type
T9218	2583-2585	SO_EXT:wild_type_entity	denotes	wt
T9219	2591-2596	PR_EXT:000004080	denotes	anxA7
T9220	2596-2597	SO_EXT:sequence_nullness_or_absence	denotes	-
T9221	2598-2599	SO_EXT:sequence_nullness_or_absence	denotes	-
T9222	2600-2606	SO_EXT:sequence_altered_entity	denotes	mutant
T9223	2632-2636	CHEBI:29108	denotes	Ca2+
T9224	2637-2646	CHEBI_EXT:24869	denotes	ionophore
T9225	2752-2758	PR_EXT:000015619	denotes	sorcin
T9226	2770-2778	GO:0042571	denotes	antibody
T9227	2792-2802	PR_EXT:000004080	denotes	annexin A7
T9228	2807-2813	PR_EXT:000015619	denotes	sorcin
T9229	2839-2847	GO:0031982	denotes	vesicles
T9230	2860-2867	SO_EXT:0001060	denotes	isoform
T9231	2871-2881	PR_EXT:000004080	denotes	annexin A7
T9232	2915-2923	GO:0031982	denotes	vesicles
T9233	2941-2949	GO:0031982	denotes	vesicles
T9234	2991-3004	CHEBI:15355	denotes	acetylcholine
T9235	2991-3013	GO_PR_EXT:acetylcholinesterase	denotes	acetylcholine esterase
T9236	3024-3029	NCBITaxon:9606	denotes	Human
T9237	3030-3045	CL:0000232	denotes	red blood cells
T9238	3034-3039	UBERON:0000178	denotes	blood
T9239	3040-3045	CL_GO_EXT:cell	denotes	cells
T9391	4055-4070	CL:0000232	denotes	red blood cells
T9392	4059-4064	UBERON:0000178	denotes	blood
T9393	4065-4070	CL_GO_EXT:cell	denotes	cells
T9394	4100-4109	CHEBI:31705	denotes	iodixanol
T9395	4278-4284	PR_EXT:000015619	denotes	sorcin
T9396	4296-4304	GO:0042571	denotes	antibody
T9479	5090-5105	CL:0000232	denotes	red blood cells
T9480	5094-5099	UBERON:0000178	denotes	blood
T9481	5100-5105	CL_GO_EXT:cell	denotes	cells
T9482	5111-5116	PR_EXT:000004080	denotes	anxA7
T9483	5116-5117	SO_EXT:sequence_nullness_or_absence	denotes	-
T9484	5118-5119	SO_EXT:sequence_nullness_or_absence	denotes	-
T9485	5120-5126	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9486	5135-5144	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T9487	5145-5149	NCBITaxon:10088	denotes	mice
T9488	5164-5172	CL_GO_EXT:cell	denotes	cellular
T9588	7411-7426	CL:0000232	denotes	red blood cells
T9589	7415-7420	UBERON:0000178	denotes	blood
T9590	7421-7426	CL_GO_EXT:cell	denotes	cells
T9591	7432-7441	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T9592	7446-7451	PR_EXT:000004080	denotes	anxA7
T9593	7451-7452	SO_EXT:sequence_nullness_or_absence	denotes	-
T9594	7453-7454	SO_EXT:sequence_nullness_or_absence	denotes	-
T9595	7455-7461	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9596	7462-7466	NCBITaxon:10088	denotes	mice
T9597	7514-7527	GO:0005576	denotes	extracellular
T9598	7519-7527	CL_GO_EXT:cell	denotes	cellular
T9599	7528-7533	CHEBI:24870	denotes	ionic
T9600	7585-7599	CL:0000232	denotes	red blood cell
T9601	7589-7594	UBERON:0000178	denotes	blood
T9602	7595-7599	CL_GO_EXT:cell	denotes	cell
T9603	7631-7646	CHEBI:26710	denotes	sodium chloride
T9604	7670-7678	CL_GO_EXT:cell	denotes	cellular
T9605	7670-7684	GO:0019835	denotes	cellular lysis
T9606	7730-7735	_FRAGMENT	denotes	lysis
T9607	7757-7759	_FRAGMENT	denotes	of
T9608	7772-7776	GO:0019835	denotes	cell
T9609	7762-7776	CL:0000232	denotes	red blood cell
T9610	7766-7771	UBERON:0000178	denotes	blood
T9611	7772-7776	CL_GO_EXT:cell	denotes	cell
T9612	7804-7814	PR_EXT:000004080	denotes	annexin A7
T9613	7825-7840	CL:0000232	denotes	red blood cells
T9614	7829-7834	UBERON:0000178	denotes	blood
T9615	7835-7840	CL_GO_EXT:cell	denotes	cells
T9616	7891-7900	SO_EXT:wild_type_entity	denotes	wild type
T9758	10619-10627	CL:0000233	denotes	Platelet
T9759	10619-10639	GO:0070527	denotes	Platelet aggregation
T9760	10652-10660	CL:0000233	denotes	platelet
T9761	10666-10672	UBERON:0001969	denotes	plasma
T9762	10676-10686	PR_EXT:000004080	denotes	annexin A7
T9763	10701-10710	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T9764	10711-10715	NCBITaxon:10088	denotes	mice
T9765	10820-10830	CHEBI:85129	denotes	ristocetin
T9766	10877-10885	CL:0000233	denotes	platelet
T9767	11069-11075	NCBITaxon:39107	denotes	murine
T9768	11143-11151	CL:0000233	denotes	platelet
T9769	11143-11162	GO:0030168	denotes	platelet initiation
T9770	11168-11174	SO_EXT:sequence_altered_entity	denotes	mutant
T9771	11252-11261	SO_EXT:wild_type_entity	denotes	wild type
T9772	11311-11320	SO_EXT:wild_type_entity	denotes	wild type
T9773	11406-11415	SO_EXT:wild_type_entity	denotes	wild type
T9774	11440-11446	NCBITaxon:39107	denotes	Murine
T9775	11447-11456	CL:0000233	denotes	platelets
T9776	11457-11462	GO_EXT:reaction_or_response	denotes	react
T9777	11493-11501	CHEBI_EXT:chemical_substance_or_polyatomic_entity	denotes	chemical
T9778	11540-11545	NCBITaxon:9606	denotes	human
T9779	11546-11555	CL:0000233	denotes	platelets
T9780	11592-11600	CL:0000233	denotes	platelet
T9781	11630-11635	NCBITaxon:9606	denotes	human
T9782	11636-11645	CL:0000233	denotes	platelets
T9069	761-771	GO:0010467	denotes	Expression
T9070	775-785	PR_EXT:000004080	denotes	annexin A7
T9071	789-794	NCBITaxon:9606	denotes	human
T9072	795-810	CL:0000232	denotes	red blood cells
T9073	799-804	UBERON:0000178	denotes	blood
T9074	805-810	CL_GO_EXT:cell	denotes	cells
T9075	819-824	NCBITaxon:9606	denotes	human
T9076	825-834	CL:0000233	denotes	platelets
T9077	840-847	CHEBI_PR_EXT:protein	denotes	Protein
T9078	878-881	CHEBI:8984	denotes	SDS
T9079	893-903	CHEBI:28619	denotes	acrylamide
T9080	995-1005	GO_EXT:0004601	denotes	peroxidase
T9081	1006-1013	MOP:0000779	denotes	coupled
T9082	1014-1022	GO:0042571	denotes	antibody
T9083	1045-1053	SO_EXT:0001060	denotes	isoforms
T9084	1070-1085	CL:0000232	denotes	red blood cells
T9085	1074-1079	UBERON:0000178	denotes	blood
T9383	3965-3975	PR_EXT:000004080	denotes	annexin A7
T9384	3980-3986	PR_EXT:000015619	denotes	sorcin
T9385	4001-4015	CL:0000232	denotes	red blood cell
T9386	4005-4010	UBERON:0000178	denotes	blood
T9387	4011-4015	CL_GO_EXT:cell	denotes	cell
T9388	4016-4031	GO:0005886	denotes	plasma membrane
T9389	4043-4048	GO:0019835	denotes	Lysed
T9390	4049-4054	NCBITaxon:9606	denotes	human
T2362	650-657	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T2363	707-714	SO_EXT:0001060	denotes	isoform
T2364	1151-1159	GO:0031982	denotes	vesicles
T2365	1200-1212	GO:0045121	denotes	raft domains
T2366	1214-1224	PR_EXT:000004080	denotes	annexin A7
T2367	1241-1249	GO:0016020	denotes	membrane
T2368	1271-1283	GO:0006900	denotes	vesiculation
T2369	1337-1352	CL:0000232	denotes	red blood cells
T2370	1341-1346	UBERON:0000178	denotes	blood
T2371	1347-1352	CL_GO_EXT:cell	denotes	cells
T2372	1370-1380	PR_EXT:000004080	denotes	annexin A7
T2373	1391-1395	NCBITaxon:10088	denotes	mice
T2374	1397-1402	PR_EXT:000004080	denotes	anxA7
T2375	1402-1403	SO_EXT:sequence_nullness_or_absence	denotes	-
T2376	1404-1405	SO_EXT:sequence_nullness_or_absence	denotes	-
T2377	1415-1426	GO:0070382	denotes	exovesicles
T2378	1551-1556	NCBITaxon:9606	denotes	human
T2379	1557-1562	UBERON:0000178	denotes	blood
T2380	1595-1605	PR_EXT:000004080	denotes	annexin A7
T2381	1620-1631	GO:0070382	denotes	exovesicles
T2382	1633-1639	_FRAGMENT	denotes	micro-
T2383	1648-1656	GO:1990742	denotes	vesicles
T2384	1663-1671	GO_EXT:biological_release	denotes	released
T2385	1678-1682	CHEBI:29108	denotes	Ca2+
T2386	1683-1692	CHEBI_EXT:24869	denotes	ionophore
T2387	1720-1733	CHEBI:15355	denotes	acetylcholine
T2388	1720-1742	GO_PR_EXT:acetylcholinesterase	denotes	acetylcholine esterase
T2389	1781-1791	PR_EXT:000004080	denotes	Annexin A7
T2390	1811-1818	GO:0031982	denotes	vesicle
T2391	1858-1866	GO:0031982	denotes	vesicles
T2392	1888-1895	SO_EXT:0001060	denotes	isoform
T2393	1922-1930	GO:0031982	denotes	vesicles
T2394	1953-1960	GO:0031982	denotes	vesicle
T2396	2014-2028	CL:0000232	denotes	red blood cell
T2417	3132-3142	PR_EXT:000004080	denotes	annexin A7
T2418	3146-3161	CL:0000232	denotes	red blood cells
T2419	3150-3155	UBERON:0000178	denotes	blood
T2420	3156-3161	CL_GO_EXT:cell	denotes	cells
T2421	3183-3192	CHEBI:31705	denotes	iodixanol
T2422	3217-3225	SO_EXT:0001060	denotes	isoforms
T2423	3345-3354	GO:0016020	denotes	membranes
T2424	3362-3371	GO:0016020	denotes	membranes
T2425	3388-3404	GO:0005886	denotes	plasma membranes
T2426	3408-3423	CL:0000232	denotes	red blood cells
T2427	3412-3417	UBERON:0000178	denotes	blood
T2428	3418-3423	CL_GO_EXT:cell	denotes	cells
T2429	3440-3450	GO:0043226	denotes	organelles
T2430	3545-3552	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T2431	3556-3566	PR_EXT:000004080	denotes	annexin A7
T2432	3570-3589	GO:0044425	denotes	membrane subdomains
T2433	3610-3615	CHEBI:18059	denotes	lipid
T2434	3619-3624	CHEBI:18059	denotes	lipid
T2435	3625-3632	CHEBI_PR_EXT:protein	denotes	protein
T2436	3690-3696	PR_EXT:000015619	denotes	sorcin
T2437	3787-3795	GO:0031982	denotes	vesicles
T2438	3826-3836	PR_EXT:000004080	denotes	annexin A7
T2439	3862-3871	CL:0000233	denotes	platelets
T2440	3876-3886	PR_EXT:000004080	denotes	annexin A7
T2441	3887-3897	GO:0010467	denotes	expression
T2442	3922-3929	SO_EXT:0001060	denotes	isoform
T3173	4319-4329	PR_EXT:000004080	denotes	annexin A7
T3174	4338-4352	CL:0000232	denotes	red blood cell
T3208	5504-5514	GO:0016020	denotes	membranous
T3209	5515-5527	GO:0005856	denotes	cytoskeleton
T3210	5539-5549	PR_EXT:000004080	denotes	annexin A7
T3211	5640-5653	GO:0005576	denotes	extracellular
T3212	5645-5653	CL_GO_EXT:cell	denotes	cellular
T3213	5654-5659	CHEBI:24870	denotes	ionic
T3214	5712-5726	CL:0000232	denotes	red blood cell
T3215	5716-5721	UBERON:0000178	denotes	blood
T3216	5722-5726	CL_GO_EXT:cell	denotes	cell
T3217	5760-5775	CHEBI:26710	denotes	sodium chloride
T3218	5799-5807	CL_GO_EXT:cell	denotes	cellular
T3219	5799-5813	GO:0019835	denotes	cellular lysis
T3220	5859-5864	_FRAGMENT	denotes	lysis
T3221	5886-5888	_FRAGMENT	denotes	of
T3222	5893-5898	GO:0019835	denotes	cells
T3223	5893-5898	CL_GO_EXT:cell	denotes	cells
T3224	5958-5965	GO:0009986	denotes	surface
T3225	5994-6002	CL_GO_EXT:cell	denotes	cellular
T3226	5994-6013	GO:0044237	denotes	cellular metabolism
T3227	6030-6043	GO:0005622	denotes	intracellular
T3228	6035-6043	CL_GO_EXT:cell	denotes	cellular
T3229	6044-6047	CHEBI:24870	denotes	ion
T3230	6056-6060	GO_PATO_EXT:aging_or_agedness	denotes	Aged
T3231	6061-6076	CL:0000232	denotes	red blood cells
T3232	6065-6070	UBERON:0000178	denotes	blood
T3233	6071-6076	CL_GO_EXT:cell	denotes	cells
T3234	6169-6184	CL:0000232	denotes	red blood cells
T3235	6173-6178	UBERON:0000178	denotes	blood
T3236	6179-6184	CL_GO_EXT:cell	denotes	cells
T3237	6198-6206	GO:0016020	denotes	membrane
R6012	T9607	T9606	_lexicallyChainedTo	of,lysis
R6013	T9608	T9607	_lexicallyChainedTo	cell,of
R1262	T2347	T2346	_lexicallyChainedTo	vesicles,micro-
R1263	T2383	T2382	_lexicallyChainedTo	vesicles,micro-
R1793	T3221	T3220	_lexicallyChainedTo	of,lysis
R1794	T3222	T3221	_lexicallyChainedTo	cells,of

PMC:194730 / 7171-18861 JSONTXT

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PMC:194730 / 7171-18861 JSON TXT