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Interestingly, the Ca2+-mediated vesiculation process was not impaired. Also, the membrane organization appeared not to be disturbed as assessed using gradient fractionation studies. Instead, lack of annexin A7 led to an altered cell shape and increased osmotic resistance of red blood cells. Annexin A7 was also identified in platelets. In these cells its loss led to a slightly slower aggregation velocity which seems to be compensated by an increased number of platelets. The results appear to rule out an important role of annexin A7 in membrane fusion processes occurring in red blood cells. Instead the protein might be involved in the organization of the membrane cytoskeleton. Red blood cells may represent an appropriate model to study the role of annexin A7 in cellular processes."}

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{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T155","span":{"begin":20,"end":30},"obj":"PR_EXT:000004080"},{"id":"T156","span":{"begin":34,"end":49},"obj":"CL:0000232"},{"id":"T157","span":{"begin":38,"end":43},"obj":"UBERON:0000178"},{"id":"T158","span":{"begin":44,"end":49},"obj":"CL_GO_EXT:cell"},{"id":"T159","span":{"begin":67,"end":79},"obj":"CL:0000232"},{"id":"T160","span":{"begin":85,"end":90},"obj":"PR_EXT:000004080"},{"id":"T161","span":{"begin":90,"end":91},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T162","span":{"begin":92,"end":93},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T163","span":{"begin":94,"end":98},"obj":"NCBITaxon:10088"},{"id":"T164","span":{"begin":119,"end":123},"obj":"CHEBI:29108"},{"id":"T165","span":{"begin":133,"end":145},"obj":"GO:0006900"},{"id":"T166","span":{"begin":182,"end":190},"obj":"GO:0016020"},{"id":"T167","span":{"begin":300,"end":310},"obj":"PR_EXT:000004080"},{"id":"T168","span":{"begin":329,"end":333},"obj":"CL_GO_EXT:cell"},{"id":"T169","span":{"begin":376,"end":391},"obj":"CL:0000232"},{"id":"T170","span":{"begin":380,"end":385},"obj":"UBERON:0000178"},{"id":"T171","span":{"begin":386,"end":391},"obj":"CL_GO_EXT:cell"},{"id":"T172","span":{"begin":393,"end":403},"obj":"PR_EXT:000004080"},{"id":"T173","span":{"begin":427,"end":436},"obj":"CL:0000233"},{"id":"T174","span":{"begin":447,"end":452},"obj":"CL_GO_EXT:cell"},{"id":"T175","span":{"begin":564,"end":573},"obj":"CL:0000233"},{"id":"T176","span":{"begin":627,"end":637},"obj":"PR_EXT:000004080"},{"id":"T177","span":{"begin":641,"end":649},"obj":"GO:0016020"},{"id":"T178","span":{"begin":641,"end":656},"obj":"GO:0061025"},{"id":"T179","span":{"begin":680,"end":695},"obj":"CL:0000232"},{"id":"T180","span":{"begin":684,"end":689},"obj":"UBERON:0000178"},{"id":"T181","span":{"begin":690,"end":695},"obj":"CL_GO_EXT:cell"},{"id":"T182","span":{"begin":709,"end":716},"obj":"CHEBI_PR_EXT:protein"},{"id":"T183","span":{"begin":762,"end":770},"obj":"GO:0016020"},{"id":"T184","span":{"begin":771,"end":783},"obj":"GO:0005856"},{"id":"T185","span":{"begin":785,"end":800},"obj":"CL:0000232"},{"id":"T186","span":{"begin":789,"end":794},"obj":"UBERON:0000178"},{"id":"T187","span":{"begin":795,"end":800},"obj":"CL_GO_EXT:cell"},{"id":"T188","span":{"begin":857,"end":867},"obj":"PR_EXT:000004080"},{"id":"T189","span":{"begin":871,"end":879},"obj":"CL_GO_EXT:cell"},{"id":"T190","span":{"begin":871,"end":889},"obj":"GO:0009987"}],"text":"Results\nThe role of annexin A7 in red blood cells was addressed in erythrocytes from anxA7-/- mice. Interestingly, the Ca2+-mediated vesiculation process was not impaired. Also, the membrane organization appeared not to be disturbed as assessed using gradient fractionation studies. Instead, lack of annexin A7 led to an altered cell shape and increased osmotic resistance of red blood cells. Annexin A7 was also identified in platelets. In these cells its loss led to a slightly slower aggregation velocity which seems to be compensated by an increased number of platelets. The results appear to rule out an important role of annexin A7 in membrane fusion processes occurring in red blood cells. Instead the protein might be involved in the organization of the membrane cytoskeleton. Red blood cells may represent an appropriate model to study the role of annexin A7 in cellular processes."}