Id |
Subject |
Object |
Predicate |
Lexical cue |
T1478 |
0-3 |
CD |
denotes |
Two |
T1479 |
12-20 |
NNS |
denotes |
partners |
T1480 |
4-11 |
VBG |
denotes |
binding |
T1481 |
45-55 |
VBN |
denotes |
identified |
T1482 |
21-23 |
IN |
denotes |
of |
T1483 |
24-31 |
NN |
denotes |
annexin |
T1484 |
32-34 |
NN |
denotes |
A7 |
T1485 |
35-39 |
VBP |
denotes |
have |
T1486 |
40-44 |
VBN |
denotes |
been |
T1487 |
55-57 |
, |
denotes |
, |
T1488 |
57-63 |
NN |
denotes |
sorcin |
T1489 |
64-67 |
CC |
denotes |
and |
T1490 |
68-76 |
NN |
denotes |
galectin |
T1491 |
76-77 |
HYPH |
denotes |
- |
T1492 |
77-78 |
CD |
denotes |
3 |
T1493 |
79-80 |
-LRB- |
denotes |
[ |
T1494 |
80-82 |
CD |
denotes |
11 |
T1495 |
82-83 |
SYM |
denotes |
- |
T1496 |
83-85 |
CD |
denotes |
13 |
T1497 |
85-86 |
-RRB- |
denotes |
] |
T1498 |
86-87 |
. |
denotes |
. |
T1499 |
87-174 |
sentence |
denotes |
Sorcin is a Ca2+-binding protein and belongs to the penta EF-hand protein family [14]. |
T1500 |
88-94 |
NN |
denotes |
Sorcin |
T1501 |
95-97 |
VBZ |
denotes |
is |
T1502 |
98-99 |
DT |
denotes |
a |
T1503 |
113-120 |
NN |
denotes |
protein |
T1504 |
100-104 |
NN |
denotes |
Ca2+ |
T1505 |
105-112 |
VBG |
denotes |
binding |
T1506 |
104-105 |
HYPH |
denotes |
- |
T1507 |
121-124 |
CC |
denotes |
and |
T1508 |
125-132 |
VBZ |
denotes |
belongs |
T1509 |
133-135 |
IN |
denotes |
to |
T1510 |
136-139 |
DT |
denotes |
the |
T1511 |
162-168 |
NN |
denotes |
family |
T1512 |
140-145 |
NN |
denotes |
penta |
T1513 |
154-161 |
NN |
denotes |
protein |
T1514 |
146-148 |
NN |
denotes |
EF |
T1515 |
149-153 |
NN |
denotes |
hand |
T1516 |
148-149 |
HYPH |
denotes |
- |
T1517 |
169-170 |
-LRB- |
denotes |
[ |
T1518 |
170-172 |
CD |
denotes |
14 |
T1519 |
172-173 |
-RRB- |
denotes |
] |
T1520 |
173-174 |
. |
denotes |
. |
T1521 |
174-240 |
sentence |
denotes |
Like annexin A7 it binds to membranes in a Ca2+-dependent manner. |
T1522 |
175-179 |
IN |
denotes |
Like |
T1523 |
194-199 |
VBZ |
denotes |
binds |
T1524 |
180-187 |
NN |
denotes |
annexin |
T1525 |
188-190 |
NN |
denotes |
A7 |
T1526 |
191-193 |
PRP |
denotes |
it |
T1527 |
200-202 |
IN |
denotes |
to |
T1528 |
203-212 |
NNS |
denotes |
membranes |
T1529 |
213-215 |
IN |
denotes |
in |
T1530 |
216-217 |
DT |
denotes |
a |
T1531 |
233-239 |
NN |
denotes |
manner |
T1532 |
218-222 |
NN |
denotes |
Ca2+ |
T1533 |
223-232 |
JJ |
denotes |
dependent |
T1534 |
222-223 |
HYPH |
denotes |
- |
T1535 |
239-240 |
. |
denotes |
. |
T1536 |
240-364 |
sentence |
denotes |
Sorcin also has been described as interaction partner of the ryanodine receptor, and appears to modulate its function [15]. |
T1537 |
241-247 |
NN |
denotes |
Sorcin |
T1538 |
262-271 |
VBN |
denotes |
described |
T1539 |
248-252 |
RB |
denotes |
also |
T1540 |
253-256 |
VBZ |
denotes |
has |
T1541 |
257-261 |
VBN |
denotes |
been |
T1542 |
272-274 |
IN |
denotes |
as |
T1543 |
275-286 |
NN |
denotes |
interaction |
T1544 |
287-294 |
NN |
denotes |
partner |
T1545 |
295-297 |
IN |
denotes |
of |
T1546 |
298-301 |
DT |
denotes |
the |
T1547 |
312-320 |
NN |
denotes |
receptor |
T1548 |
302-311 |
NN |
denotes |
ryanodine |
T1549 |
320-322 |
, |
denotes |
, |
T1550 |
322-325 |
CC |
denotes |
and |
T1551 |
326-333 |
VBZ |
denotes |
appears |
T1552 |
334-336 |
TO |
denotes |
to |
T1553 |
337-345 |
VB |
denotes |
modulate |
T1554 |
346-349 |
PRP$ |
denotes |
its |
T1555 |
350-358 |
NN |
denotes |
function |
T1556 |
359-360 |
-LRB- |
denotes |
[ |
T1557 |
360-362 |
CD |
denotes |
15 |
T1558 |
362-363 |
-RRB- |
denotes |
] |
T1559 |
363-364 |
. |
denotes |
. |
T1560 |
364-453 |
sentence |
denotes |
The influence of the sorcin/annexin A7 interaction on the ryanodine receptor is unknown. |
T1561 |
365-368 |
DT |
denotes |
The |
T1562 |
369-378 |
NN |
denotes |
influence |
T1563 |
442-444 |
VBZ |
denotes |
is |
T1564 |
379-381 |
IN |
denotes |
of |
T1565 |
382-385 |
DT |
denotes |
the |
T1566 |
404-415 |
NN |
denotes |
interaction |
T1567 |
386-392 |
NN |
denotes |
sorcin |
T1568 |
393-400 |
NN |
denotes |
annexin |
T1569 |
392-393 |
HYPH |
denotes |
/ |
T1570 |
401-403 |
NN |
denotes |
A7 |
T1571 |
416-418 |
IN |
denotes |
on |
T1572 |
419-422 |
DT |
denotes |
the |
T1573 |
433-441 |
NN |
denotes |
receptor |
T1574 |
423-432 |
NN |
denotes |
ryanodine |
T1575 |
445-452 |
JJ |
denotes |
unknown |
T1576 |
452-453 |
. |
denotes |
. |
T1577 |
453-528 |
sentence |
denotes |
Sorcin and annexin A7 are coexpressed in all tissues examined so far [11]. |
T1578 |
454-460 |
NN |
denotes |
Sorcin |
T1579 |
480-491 |
VBN |
denotes |
coexpressed |
T1580 |
461-464 |
CC |
denotes |
and |
T1581 |
465-472 |
NN |
denotes |
annexin |
T1582 |
473-475 |
NN |
denotes |
A7 |
T1583 |
476-479 |
VBP |
denotes |
are |
T1584 |
492-494 |
IN |
denotes |
in |
T1585 |
495-498 |
DT |
denotes |
all |
T1586 |
499-506 |
NNS |
denotes |
tissues |
T1587 |
507-515 |
VBN |
denotes |
examined |
T1588 |
516-518 |
RB |
denotes |
so |
T1589 |
519-522 |
RB |
denotes |
far |
T1590 |
523-524 |
-LRB- |
denotes |
[ |
T1591 |
524-526 |
CD |
denotes |
11 |
T1592 |
526-527 |
-RRB- |
denotes |
] |
T1593 |
527-528 |
. |
denotes |
. |
T1594 |
528-629 |
sentence |
denotes |
The binding of annexin A7 and sorcin is Ca2+-dependent and occurs at micromolar Ca2+ concentrations. |
T1595 |
529-532 |
DT |
denotes |
The |
T1596 |
533-540 |
NN |
denotes |
binding |
T1597 |
566-568 |
VBZ |
denotes |
is |
T1598 |
541-543 |
IN |
denotes |
of |
T1599 |
544-551 |
NN |
denotes |
annexin |
T1600 |
552-554 |
NN |
denotes |
A7 |
T1601 |
555-558 |
CC |
denotes |
and |
T1602 |
559-565 |
NN |
denotes |
sorcin |
T1603 |
569-573 |
NN |
denotes |
Ca2+ |
T1604 |
574-583 |
JJ |
denotes |
dependent |
T1605 |
573-574 |
HYPH |
denotes |
- |
T1606 |
584-587 |
CC |
denotes |
and |
T1607 |
588-594 |
VBZ |
denotes |
occurs |
T1608 |
595-597 |
IN |
denotes |
at |
T1609 |
598-608 |
JJ |
denotes |
micromolar |
T1610 |
609-613 |
NN |
denotes |
Ca2+ |
T1611 |
614-628 |
NNS |
denotes |
concentrations |
T1612 |
628-629 |
. |
denotes |
. |
T1613 |
629-779 |
sentence |
denotes |
The binding sites have been localised to the amino terminal GGYY and GYGG motifs in sorcin and to the GYPP motif in the amino terminus of annexin A7. |
T1614 |
630-633 |
DT |
denotes |
The |
T1615 |
642-647 |
NNS |
denotes |
sites |
T1616 |
634-641 |
VBG |
denotes |
binding |
T1617 |
658-667 |
VBN |
denotes |
localised |
T1618 |
648-652 |
VBP |
denotes |
have |
T1619 |
653-657 |
VBN |
denotes |
been |
T1620 |
668-670 |
IN |
denotes |
to |
T1621 |
671-674 |
DT |
denotes |
the |
T1622 |
704-710 |
NNS |
denotes |
motifs |
T1623 |
675-680 |
NN |
denotes |
amino |
T1624 |
681-689 |
JJ |
denotes |
terminal |
T1625 |
690-694 |
NN |
denotes |
GGYY |
T1626 |
695-698 |
CC |
denotes |
and |
T1627 |
699-703 |
NN |
denotes |
GYGG |
T1628 |
711-713 |
IN |
denotes |
in |
T1629 |
714-720 |
NN |
denotes |
sorcin |
T1630 |
721-724 |
CC |
denotes |
and |
T1631 |
725-727 |
IN |
denotes |
to |
T1632 |
728-731 |
DT |
denotes |
the |
T1633 |
737-742 |
NN |
denotes |
motif |
T1634 |
732-736 |
NN |
denotes |
GYPP |
T1635 |
743-745 |
IN |
denotes |
in |
T1636 |
746-749 |
DT |
denotes |
the |
T1637 |
756-764 |
NN |
denotes |
terminus |
T1638 |
750-755 |
NN |
denotes |
amino |
T1639 |
765-767 |
IN |
denotes |
of |
T1640 |
768-775 |
NN |
denotes |
annexin |
T1641 |
776-778 |
NN |
denotes |
A7 |
T1642 |
778-779 |
. |
denotes |
. |
T1643 |
779-886 |
sentence |
denotes |
The proteins bind to each other with a stoichiometry of two sorcin molecules per annexin A7 molecule [12]. |
T1644 |
780-783 |
DT |
denotes |
The |
T1645 |
784-792 |
NN |
denotes |
proteins |
T1646 |
793-797 |
VBP |
denotes |
bind |
T1647 |
798-800 |
IN |
denotes |
to |
T1648 |
801-805 |
DT |
denotes |
each |
T1649 |
806-811 |
JJ |
denotes |
other |
T1650 |
812-816 |
IN |
denotes |
with |
T1651 |
817-818 |
DT |
denotes |
a |
T1652 |
819-832 |
NN |
denotes |
stoichiometry |
T1653 |
833-835 |
IN |
denotes |
of |
T1654 |
836-839 |
CD |
denotes |
two |
T1655 |
847-856 |
NNS |
denotes |
molecules |
T1656 |
840-846 |
NN |
denotes |
sorcin |
T1657 |
857-860 |
IN |
denotes |
per |
T1658 |
861-868 |
NN |
denotes |
annexin |
T1659 |
869-871 |
NN |
denotes |
A7 |
T1660 |
872-880 |
NN |
denotes |
molecule |
T1661 |
881-882 |
-LRB- |
denotes |
[ |
T1662 |
882-884 |
CD |
denotes |
12 |
T1663 |
884-885 |
-RRB- |
denotes |
] |
T1664 |
885-886 |
. |
denotes |
. |
R632 |
T1478 |
T1479 |
nummod |
Two,partners |
R633 |
T1479 |
T1481 |
nsubjpass |
partners,identified |
R634 |
T1480 |
T1479 |
amod |
binding,partners |
R635 |
T1482 |
T1479 |
prep |
of,partners |
R636 |
T1483 |
T1484 |
compound |
annexin,A7 |
R637 |
T1484 |
T1482 |
pobj |
A7,of |
R638 |
T1485 |
T1481 |
aux |
have,identified |
R639 |
T1486 |
T1481 |
auxpass |
been,identified |
R640 |
T1487 |
T1481 |
punct |
", ",identified |
R641 |
T1488 |
T1481 |
dobj |
sorcin,identified |
R642 |
T1489 |
T1488 |
cc |
and,sorcin |
R643 |
T1490 |
T1488 |
conj |
galectin,sorcin |
R644 |
T1491 |
T1490 |
punct |
-,galectin |
R645 |
T1492 |
T1490 |
nummod |
3,galectin |
R646 |
T1493 |
T1494 |
punct |
[,11 |
R647 |
T1494 |
T1481 |
parataxis |
11,identified |
R648 |
T1495 |
T1496 |
punct |
-,13 |
R649 |
T1496 |
T1494 |
prep |
13,11 |
R650 |
T1497 |
T1494 |
punct |
],11 |
R651 |
T1498 |
T1481 |
punct |
.,identified |
R652 |
T1500 |
T1501 |
nsubj |
Sorcin,is |
R653 |
T1502 |
T1503 |
det |
a,protein |
R654 |
T1503 |
T1501 |
attr |
protein,is |
R655 |
T1504 |
T1505 |
npadvmod |
Ca2+,binding |
R656 |
T1505 |
T1503 |
amod |
binding,protein |
R657 |
T1506 |
T1505 |
punct |
-,binding |
R658 |
T1507 |
T1501 |
cc |
and,is |
R659 |
T1508 |
T1501 |
conj |
belongs,is |
R660 |
T1509 |
T1508 |
prep |
to,belongs |
R661 |
T1510 |
T1511 |
det |
the,family |
R662 |
T1511 |
T1509 |
pobj |
family,to |
R663 |
T1512 |
T1513 |
compound |
penta,protein |
R664 |
T1513 |
T1511 |
compound |
protein,family |
R665 |
T1514 |
T1515 |
compound |
EF,hand |
R666 |
T1515 |
T1513 |
compound |
hand,protein |
R667 |
T1516 |
T1515 |
punct |
-,hand |
R668 |
T1517 |
T1518 |
punct |
[,14 |
R669 |
T1518 |
T1508 |
parataxis |
14,belongs |
R670 |
T1519 |
T1518 |
punct |
],14 |
R671 |
T1520 |
T1501 |
punct |
.,is |
R672 |
T1522 |
T1523 |
prep |
Like,binds |
R673 |
T1524 |
T1525 |
compound |
annexin,A7 |
R674 |
T1525 |
T1522 |
pobj |
A7,Like |
R675 |
T1526 |
T1523 |
nsubj |
it,binds |
R676 |
T1527 |
T1523 |
prep |
to,binds |
R677 |
T1528 |
T1527 |
pobj |
membranes,to |
R678 |
T1529 |
T1523 |
prep |
in,binds |
R679 |
T1530 |
T1531 |
det |
a,manner |
R680 |
T1531 |
T1529 |
pobj |
manner,in |
R681 |
T1532 |
T1533 |
npadvmod |
Ca2+,dependent |
R682 |
T1533 |
T1531 |
amod |
dependent,manner |
R683 |
T1534 |
T1533 |
punct |
-,dependent |
R684 |
T1535 |
T1523 |
punct |
.,binds |
R685 |
T1537 |
T1538 |
nsubjpass |
Sorcin,described |
R686 |
T1539 |
T1538 |
advmod |
also,described |
R687 |
T1540 |
T1538 |
aux |
has,described |
R688 |
T1541 |
T1538 |
auxpass |
been,described |
R689 |
T1542 |
T1538 |
prep |
as,described |
R690 |
T1543 |
T1544 |
compound |
interaction,partner |
R691 |
T1544 |
T1542 |
pobj |
partner,as |
R692 |
T1545 |
T1544 |
prep |
of,partner |
R693 |
T1546 |
T1547 |
det |
the,receptor |
R694 |
T1547 |
T1545 |
pobj |
receptor,of |
R695 |
T1548 |
T1547 |
compound |
ryanodine,receptor |
R696 |
T1549 |
T1538 |
punct |
", ",described |
R697 |
T1550 |
T1538 |
cc |
and,described |
R698 |
T1551 |
T1538 |
conj |
appears,described |
R699 |
T1552 |
T1553 |
aux |
to,modulate |
R700 |
T1553 |
T1551 |
xcomp |
modulate,appears |
R701 |
T1554 |
T1555 |
poss |
its,function |
R702 |
T1555 |
T1553 |
dobj |
function,modulate |
R703 |
T1556 |
T1557 |
punct |
[,15 |
R704 |
T1557 |
T1551 |
parataxis |
15,appears |
R705 |
T1558 |
T1557 |
punct |
],15 |
R706 |
T1559 |
T1538 |
punct |
.,described |
R707 |
T1561 |
T1562 |
det |
The,influence |
R708 |
T1562 |
T1563 |
nsubj |
influence,is |
R709 |
T1564 |
T1562 |
prep |
of,influence |
R710 |
T1565 |
T1566 |
det |
the,interaction |
R711 |
T1566 |
T1564 |
pobj |
interaction,of |
R712 |
T1567 |
T1568 |
compound |
sorcin,annexin |
R713 |
T1568 |
T1570 |
compound |
annexin,A7 |
R714 |
T1569 |
T1568 |
punct |
/,annexin |
R715 |
T1570 |
T1566 |
compound |
A7,interaction |
R716 |
T1571 |
T1562 |
prep |
on,influence |
R717 |
T1572 |
T1573 |
det |
the,receptor |
R718 |
T1573 |
T1571 |
pobj |
receptor,on |
R719 |
T1574 |
T1573 |
compound |
ryanodine,receptor |
R720 |
T1575 |
T1563 |
acomp |
unknown,is |
R721 |
T1576 |
T1563 |
punct |
.,is |
R722 |
T1578 |
T1579 |
nsubjpass |
Sorcin,coexpressed |
R723 |
T1580 |
T1578 |
cc |
and,Sorcin |
R724 |
T1581 |
T1582 |
compound |
annexin,A7 |
R725 |
T1582 |
T1578 |
conj |
A7,Sorcin |
R726 |
T1583 |
T1579 |
auxpass |
are,coexpressed |
R727 |
T1584 |
T1579 |
prep |
in,coexpressed |
R728 |
T1585 |
T1586 |
det |
all,tissues |
R729 |
T1586 |
T1584 |
pobj |
tissues,in |
R730 |
T1587 |
T1586 |
acl |
examined,tissues |
R731 |
T1588 |
T1589 |
advmod |
so,far |
R732 |
T1589 |
T1587 |
advmod |
far,examined |
R733 |
T1590 |
T1591 |
punct |
[,11 |
R734 |
T1591 |
T1579 |
parataxis |
11,coexpressed |
R735 |
T1592 |
T1591 |
punct |
],11 |
R736 |
T1593 |
T1579 |
punct |
.,coexpressed |
R737 |
T1595 |
T1596 |
det |
The,binding |
R738 |
T1596 |
T1597 |
nsubj |
binding,is |
R739 |
T1598 |
T1596 |
prep |
of,binding |
R740 |
T1599 |
T1600 |
compound |
annexin,A7 |
R741 |
T1600 |
T1598 |
pobj |
A7,of |
R742 |
T1601 |
T1600 |
cc |
and,A7 |
R743 |
T1602 |
T1600 |
conj |
sorcin,A7 |
R744 |
T1603 |
T1604 |
npadvmod |
Ca2+,dependent |
R745 |
T1604 |
T1597 |
acomp |
dependent,is |
R746 |
T1605 |
T1604 |
punct |
-,dependent |
R747 |
T1606 |
T1597 |
cc |
and,is |
R748 |
T1607 |
T1597 |
conj |
occurs,is |
R749 |
T1608 |
T1607 |
prep |
at,occurs |
R750 |
T1609 |
T1610 |
amod |
micromolar,Ca2+ |
R751 |
T1610 |
T1611 |
compound |
Ca2+,concentrations |
R752 |
T1611 |
T1608 |
pobj |
concentrations,at |
R753 |
T1612 |
T1597 |
punct |
.,is |
R754 |
T1614 |
T1615 |
det |
The,sites |
R755 |
T1615 |
T1617 |
nsubjpass |
sites,localised |
R756 |
T1616 |
T1615 |
amod |
binding,sites |
R757 |
T1618 |
T1617 |
aux |
have,localised |
R758 |
T1619 |
T1617 |
auxpass |
been,localised |
R759 |
T1620 |
T1617 |
prep |
to,localised |
R760 |
T1621 |
T1622 |
det |
the,motifs |
R761 |
T1622 |
T1620 |
pobj |
motifs,to |
R762 |
T1623 |
T1624 |
npadvmod |
amino,terminal |
R763 |
T1624 |
T1622 |
amod |
terminal,motifs |
R764 |
T1625 |
T1622 |
nmod |
GGYY,motifs |
R765 |
T1626 |
T1625 |
cc |
and,GGYY |
R766 |
T1627 |
T1625 |
conj |
GYGG,GGYY |
R767 |
T1628 |
T1622 |
prep |
in,motifs |
R768 |
T1629 |
T1628 |
pobj |
sorcin,in |
R769 |
T1630 |
T1620 |
cc |
and,to |
R770 |
T1631 |
T1620 |
conj |
to,to |
R771 |
T1632 |
T1633 |
det |
the,motif |
R772 |
T1633 |
T1631 |
pobj |
motif,to |
R773 |
T1634 |
T1633 |
compound |
GYPP,motif |
R774 |
T1635 |
T1633 |
prep |
in,motif |
R775 |
T1636 |
T1637 |
det |
the,terminus |
R776 |
T1637 |
T1635 |
pobj |
terminus,in |
R777 |
T1638 |
T1637 |
compound |
amino,terminus |
R778 |
T1639 |
T1637 |
prep |
of,terminus |
R779 |
T1640 |
T1641 |
compound |
annexin,A7 |
R780 |
T1641 |
T1639 |
pobj |
A7,of |
R781 |
T1642 |
T1617 |
punct |
.,localised |
R782 |
T1644 |
T1645 |
det |
The,proteins |
R783 |
T1645 |
T1646 |
nsubj |
proteins,bind |
R784 |
T1647 |
T1646 |
prep |
to,bind |
R785 |
T1648 |
T1649 |
det |
each,other |
R786 |
T1649 |
T1647 |
pobj |
other,to |
R787 |
T1650 |
T1646 |
prep |
with,bind |
R788 |
T1651 |
T1652 |
det |
a,stoichiometry |
R789 |
T1652 |
T1650 |
pobj |
stoichiometry,with |
R790 |
T1653 |
T1652 |
prep |
of,stoichiometry |
R791 |
T1654 |
T1655 |
nummod |
two,molecules |
R792 |
T1655 |
T1653 |
pobj |
molecules,of |
R793 |
T1656 |
T1655 |
compound |
sorcin,molecules |
R794 |
T1657 |
T1655 |
prep |
per,molecules |
R795 |
T1658 |
T1659 |
compound |
annexin,A7 |
R796 |
T1659 |
T1660 |
compound |
A7,molecule |
R797 |
T1660 |
T1657 |
pobj |
molecule,per |
R798 |
T1661 |
T1662 |
punct |
[,12 |
R799 |
T1662 |
T1646 |
parataxis |
12,bind |
R800 |
T1663 |
T1662 |
punct |
],12 |
R801 |
T1664 |
T1646 |
punct |
.,bind |