PMC:194730 / 26355-27097
Annnotations
craft-sa-dev
{"project":"craft-sa-dev","denotations":[{"id":"T6643","span":{"begin":12,"end":14},"obj":"IN"},{"id":"T6644","span":{"begin":29,"end":35},"obj":"VBP"},{"id":"T6645","span":{"begin":15,"end":19},"obj":"DT"},{"id":"T6646","span":{"begin":20,"end":25},"obj":"NN"},{"id":"T6647","span":{"begin":26,"end":28},"obj":"PRP"},{"id":"T6648","span":{"begin":36,"end":39},"obj":"DT"},{"id":"T6649","span":{"begin":40,"end":48},"obj":"NN"},{"id":"T6650","span":{"begin":49,"end":51},"obj":"IN"},{"id":"T6651","span":{"begin":52,"end":56},"obj":"CC"},{"id":"T6652","span":{"begin":68,"end":76},"obj":"NNS"},{"id":"T6653","span":{"begin":57,"end":64},"obj":"NN"},{"id":"T6654","span":{"begin":65,"end":67},"obj":"NN"},{"id":"T6655","span":{"begin":77,"end":79},"obj":"IN"},{"id":"T6656","span":{"begin":80,"end":83},"obj":"JJ"},{"id":"T6657","span":{"begin":90,"end":95},"obj":"NNS"},{"id":"T6658","span":{"begin":84,"end":89},"obj":"NN"},{"id":"T6659","span":{"begin":96,"end":101},"obj":"WRB"},{"id":"T6660","span":{"begin":107,"end":110},"obj":"VBP"},{"id":"T6661","span":{"begin":102,"end":106},"obj":"PRP"},{"id":"T6662","span":{"begin":111,"end":119},"obj":"JJ"},{"id":"T6663","span":{"begin":120,"end":122},"obj":"IN"},{"id":"T6664","span":{"begin":123,"end":135},"obj":"NNS"},{"id":"T6665","span":{"begin":136,"end":140},"obj":"WDT"},{"id":"T6666","span":{"begin":141,"end":145},"obj":"VBP"},{"id":"T6667","span":{"begin":146,"end":150},"obj":"IN"},{"id":"T6668","span":{"begin":151,"end":155},"obj":"NN"},{"id":"T6669","span":{"begin":156,"end":164},"obj":"NN"},{"id":"T6670","span":{"begin":164,"end":165},"obj":"."},{"id":"T6671","span":{"begin":165,"end":233},"obj":"sentence"},{"id":"T6672","span":{"begin":166,"end":169},"obj":"DT"},{"id":"T6673","span":{"begin":170,"end":178},"obj":"NN"},{"id":"T6674","span":{"begin":195,"end":203},"obj":"VBN"},{"id":"T6675","span":{"begin":179,"end":182},"obj":"VBP"},{"id":"T6676","span":{"begin":183,"end":190},"obj":"RB"},{"id":"T6677","span":{"begin":191,"end":194},"obj":"RB"},{"id":"T6678","span":{"begin":204,"end":207},"obj":"IN"},{"id":"T6679","span":{"begin":208,"end":211},"obj":"DT"},{"id":"T6680","span":{"begin":225,"end":232},"obj":"NN"},{"id":"T6681","span":{"begin":212,"end":224},"obj":"NN"},{"id":"T6682","span":{"begin":232,"end":233},"obj":"."},{"id":"T6683","span":{"begin":233,"end":497},"obj":"sentence"},{"id":"T6684","span":{"begin":234,"end":238},"obj":"PRP"},{"id":"T6685","span":{"begin":239,"end":242},"obj":"VBP"},{"id":"T6686","span":{"begin":243,"end":247},"obj":"RB"},{"id":"T6687","span":{"begin":248,"end":251},"obj":"RB"},{"id":"T6688","span":{"begin":252,"end":261},"obj":"JJ"},{"id":"T6689","span":{"begin":262,"end":265},"obj":"IN"},{"id":"T6690","span":{"begin":266,"end":269},"obj":"DT"},{"id":"T6691","span":{"begin":270,"end":279},"obj":"NN"},{"id":"T6692","span":{"begin":280,"end":282},"obj":"IN"},{"id":"T6693","span":{"begin":283,"end":291},"obj":"JJ"},{"id":"T6694","span":{"begin":301,"end":308},"obj":"NNS"},{"id":"T6695","span":{"begin":292,"end":300},"obj":"NN"},{"id":"T6696","span":{"begin":309,"end":313},"obj":"JJ"},{"id":"T6697","span":{"begin":314,"end":316},"obj":"IN"},{"id":"T6698","span":{"begin":317,"end":322},"obj":"NN"},{"id":"T6699","span":{"begin":323,"end":328},"obj":"NNS"},{"id":"T6700","span":{"begin":328,"end":330},"obj":","},{"id":"T6701","span":{"begin":330,"end":332},"obj":"IN"},{"id":"T6702","span":{"begin":333,"end":344},"obj":"RB"},{"id":"T6703","span":{"begin":345,"end":350},"obj":"VBN"},{"id":"T6704","span":{"begin":371,"end":373},"obj":"NN"},{"id":"T6705","span":{"begin":351,"end":362},"obj":"JJ"},{"id":"T6706","span":{"begin":363,"end":370},"obj":"NN"},{"id":"T6707","span":{"begin":374,"end":387},"obj":"VBN"},{"id":"T6708","span":{"begin":388,"end":390},"obj":"IN"},{"id":"T6709","span":{"begin":391,"end":398},"obj":"JJ"},{"id":"T6710","span":{"begin":399,"end":408},"obj":"NNS"},{"id":"T6711","span":{"begin":409,"end":411},"obj":"IN"},{"id":"T6712","span":{"begin":412,"end":413},"obj":"DT"},{"id":"T6713","span":{"begin":422,"end":430},"obj":"NN"},{"id":"T6714","span":{"begin":414,"end":421},"obj":"NN"},{"id":"T6715","span":{"begin":431,"end":441},"obj":"VBG"},{"id":"T6716","span":{"begin":442,"end":451},"obj":"NNS"},{"id":"T6717","span":{"begin":452,"end":459},"obj":"VBN"},{"id":"T6718","span":{"begin":460,"end":464},"obj":"IN"},{"id":"T6719","span":{"begin":465,"end":468},"obj":"JJ"},{"id":"T6720","span":{"begin":475,"end":480},"obj":"NNS"},{"id":"T6721","span":{"begin":469,"end":474},"obj":"NN"},{"id":"T6722","span":{"begin":481,"end":483},"obj":"IN"},{"id":"T6723","span":{"begin":484,"end":489},"obj":"NN"},{"id":"T6724","span":{"begin":492,"end":496},"obj":"NNS"},{"id":"T6725","span":{"begin":489,"end":490},"obj":"SYM"},{"id":"T6726","span":{"begin":490,"end":491},"obj":"HYPH"},{"id":"T6727","span":{"begin":491,"end":492},"obj":"SYM"},{"id":"T6728","span":{"begin":496,"end":497},"obj":"."},{"id":"T6729","span":{"begin":497,"end":624},"obj":"sentence"},{"id":"T6730","span":{"begin":498,"end":501},"obj":"DT"},{"id":"T6731","span":{"begin":522,"end":528},"obj":"NN"},{"id":"T6732","span":{"begin":502,"end":510},"obj":"VBN"},{"id":"T6733","span":{"begin":511,"end":515},"obj":"NN"},{"id":"T6734","span":{"begin":516,"end":521},"obj":"NN"},{"id":"T6735","span":{"begin":570,"end":572},"obj":"VB"},{"id":"T6736","span":{"begin":529,"end":531},"obj":"IN"},{"id":"T6737","span":{"begin":532,"end":544},"obj":"NNS"},{"id":"T6738","span":{"begin":545,"end":552},"obj":"VBG"},{"id":"T6739","span":{"begin":553,"end":560},"obj":"NN"},{"id":"T6740","span":{"begin":561,"end":563},"obj":"NN"},{"id":"T6741","span":{"begin":564,"end":569},"obj":"MD"},{"id":"T6742","span":{"begin":573,"end":576},"obj":"IN"},{"id":"T6743","span":{"begin":577,"end":579},"obj":"IN"},{"id":"T6744","span":{"begin":580,"end":591},"obj":"NNS"},{"id":"T6745","span":{"begin":592,"end":594},"obj":"IN"},{"id":"T6746","span":{"begin":595,"end":598},"obj":"DT"},{"id":"T6747","span":{"begin":611,"end":623},"obj":"NN"},{"id":"T6748","span":{"begin":599,"end":610},"obj":"NN"},{"id":"T6749","span":{"begin":623,"end":624},"obj":"."},{"id":"T6750","span":{"begin":624,"end":742},"obj":"sentence"},{"id":"T6751","span":{"begin":625,"end":627},"obj":"IN"},{"id":"T6752","span":{"begin":666,"end":671},"obj":"VBN"},{"id":"T6753","span":{"begin":628,"end":629},"obj":"DT"},{"id":"T6754","span":{"begin":637,"end":648},"obj":"NN"},{"id":"T6755","span":{"begin":630,"end":636},"obj":"JJ"},{"id":"T6756","span":{"begin":649,"end":653},"obj":"IN"},{"id":"T6757","span":{"begin":654,"end":655},"obj":"NN"},{"id":"T6758","span":{"begin":656,"end":661},"obj":"NN"},{"id":"T6759","span":{"begin":655,"end":656},"obj":"HYPH"},{"id":"T6760","span":{"begin":662,"end":665},"obj":"VBD"},{"id":"T6761","span":{"begin":698,"end":706},"obj":"VBN"},{"id":"T6762","span":{"begin":672,"end":675},"obj":"RP"},{"id":"T6763","span":{"begin":675,"end":677},"obj":","},{"id":"T6764","span":{"begin":677,"end":681},"obj":"DT"},{"id":"T6765","span":{"begin":682,"end":688},"obj":"NN"},{"id":"T6766","span":{"begin":689,"end":694},"obj":"MD"},{"id":"T6767","span":{"begin":695,"end":697},"obj":"VB"},{"id":"T6768","span":{"begin":707,"end":709},"obj":"IN"},{"id":"T6769","span":{"begin":710,"end":717},"obj":"NN"},{"id":"T6770","span":{"begin":733,"end":741},"obj":"NN"},{"id":"T6771","span":{"begin":717,"end":719},"obj":"POS"},{"id":"T6772","span":{"begin":720,"end":724},"obj":"NN"},{"id":"T6773","span":{"begin":725,"end":732},"obj":"VBG"},{"id":"T6774","span":{"begin":724,"end":725},"obj":"HYPH"},{"id":"T6775","span":{"begin":741,"end":742},"obj":"."}],"relations":[{"id":"R4028","pred":"prep","subj":"T6643","obj":"T6644"},{"id":"R4029","pred":"det","subj":"T6645","obj":"T6646"},{"id":"R4030","pred":"pobj","subj":"T6646","obj":"T6643"},{"id":"R4031","pred":"nsubj","subj":"T6647","obj":"T6644"},{"id":"R4032","pred":"det","subj":"T6648","obj":"T6649"},{"id":"R4033","pred":"dobj","subj":"T6649","obj":"T6644"},{"id":"R4034","pred":"prep","subj":"T6650","obj":"T6649"},{"id":"R4035","pred":"preconj","subj":"T6651","obj":"T6652"},{"id":"R4036","pred":"pobj","subj":"T6652","obj":"T6650"},{"id":"R4037","pred":"compound","subj":"T6653","obj":"T6654"},{"id":"R4038","pred":"compound","subj":"T6654","obj":"T6652"},{"id":"R4039","pred":"prep","subj":"T6655","obj":"T6649"},{"id":"R4040","pred":"amod","subj":"T6656","obj":"T6657"},{"id":"R4041","pred":"pobj","subj":"T6657","obj":"T6655"},{"id":"R4042","pred":"compound","subj":"T6658","obj":"T6657"},{"id":"R4043","pred":"advmod","subj":"T6659","obj":"T6660"},{"id":"R4044","pred":"relcl","subj":"T6660","obj":"T6657"},{"id":"R4045","pred":"nsubj","subj":"T6661","obj":"T6660"},{"id":"R4046","pred":"acomp","subj":"T6662","obj":"T6660"},{"id":"R4047","pred":"prep","subj":"T6663","obj":"T6660"},{"id":"R4048","pred":"pobj","subj":"T6664","obj":"T6663"},{"id":"R4049","pred":"dep","subj":"T6665","obj":"T6666"},{"id":"R4050","pred":"relcl","subj":"T6666","obj":"T6664"},{"id":"R4051","pred":"prep","subj":"T6667","obj":"T6666"},{"id":"R4052","pred":"compound","subj":"T6668","obj":"T6669"},{"id":"R4053","pred":"pobj","subj":"T6669","obj":"T6667"},{"id":"R4054","pred":"punct","subj":"T6670","obj":"T6644"},{"id":"R4055","pred":"det","subj":"T6672","obj":"T6673"},{"id":"R4056","pred":"nsubjpass","subj":"T6673","obj":"T6674"},{"id":"R4057","pred":"auxpass","subj":"T6675","obj":"T6674"},{"id":"R4058","pred":"advmod","subj":"T6676","obj":"T6674"},{"id":"R4059","pred":"neg","subj":"T6677","obj":"T6674"},{"id":"R4060","pred":"prep","subj":"T6678","obj":"T6674"},{"id":"R4061","pred":"det","subj":"T6679","obj":"T6680"},{"id":"R4062","pred":"pobj","subj":"T6680","obj":"T6678"},{"id":"R4063","pred":"compound","subj":"T6681","obj":"T6680"},{"id":"R4064","pred":"punct","subj":"T6682","obj":"T6674"},{"id":"R4065","pred":"nsubj","subj":"T6684","obj":"T6685"},{"id":"R4066","pred":"advmod","subj":"T6686","obj":"T6685"},{"id":"R4067","pred":"neg","subj":"T6687","obj":"T6685"},{"id":"R4068","pred":"acomp","subj":"T6688","obj":"T6685"},{"id":"R4069","pred":"prep","subj":"T6689","obj":"T6688"},{"id":"R4070","pred":"det","subj":"T6690","obj":"T6691"},{"id":"R4071","pred":"pobj","subj":"T6691","obj":"T6689"},{"id":"R4072","pred":"prep","subj":"T6692","obj":"T6691"},{"id":"R4073","pred":"amod","subj":"T6693","obj":"T6694"},{"id":"R4074","pred":"pobj","subj":"T6694","obj":"T6692"},{"id":"R4075","pred":"compound","subj":"T6695","obj":"T6694"},{"id":"R4076","pred":"amod","subj":"T6696","obj":"T6697"},{"id":"R4077","pred":"prep","subj":"T6697","obj":"T6694"},{"id":"R4078","pred":"compound","subj":"T6698","obj":"T6699"},{"id":"R4079","pred":"pobj","subj":"T6699","obj":"T6697"},{"id":"R4080","pred":"punct","subj":"T6700","obj":"T6685"},{"id":"R4081","pred":"prep","subj":"T6701","obj":"T6685"},{"id":"R4082","pred":"advmod","subj":"T6702","obj":"T6703"},{"id":"R4083","pred":"amod","subj":"T6703","obj":"T6704"},{"id":"R4084","pred":"pobj","subj":"T6704","obj":"T6701"},{"id":"R4085","pred":"amod","subj":"T6705","obj":"T6704"},{"id":"R4086","pred":"compound","subj":"T6706","obj":"T6704"},{"id":"R4087","pred":"acl","subj":"T6707","obj":"T6704"},{"id":"R4088","pred":"prep","subj":"T6708","obj":"T6707"},{"id":"R4089","pred":"amod","subj":"T6709","obj":"T6710"},{"id":"R4090","pred":"pobj","subj":"T6710","obj":"T6708"},{"id":"R4091","pred":"prep","subj":"T6711","obj":"T6704"},{"id":"R4092","pred":"det","subj":"T6712","obj":"T6713"},{"id":"R4093","pred":"pobj","subj":"T6713","obj":"T6711"},{"id":"R4094","pred":"compound","subj":"T6714","obj":"T6713"},{"id":"R4095","pred":"acl","subj":"T6715","obj":"T6713"},{"id":"R4096","pred":"dobj","subj":"T6716","obj":"T6715"},{"id":"R4097","pred":"acl","subj":"T6717","obj":"T6716"},{"id":"R4098","pred":"prep","subj":"T6718","obj":"T6717"},{"id":"R4099","pred":"amod","subj":"T6719","obj":"T6720"},{"id":"R4100","pred":"pobj","subj":"T6720","obj":"T6718"},{"id":"R4101","pred":"compound","subj":"T6721","obj":"T6720"},{"id":"R4102","pred":"prep","subj":"T6722","obj":"T6720"},{"id":"R4103","pred":"nmod","subj":"T6723","obj":"T6724"},{"id":"R4104","pred":"pobj","subj":"T6724","obj":"T6722"},{"id":"R4105","pred":"punct","subj":"T6725","obj":"T6723"},{"id":"R4106","pred":"punct","subj":"T6726","obj":"T6723"},{"id":"R4107","pred":"punct","subj":"T6727","obj":"T6723"},{"id":"R4108","pred":"punct","subj":"T6728","obj":"T6685"},{"id":"R4109","pred":"det","subj":"T6730","obj":"T6731"},{"id":"R4110","pred":"nsubj","subj":"T6731","obj":"T6735"},{"id":"R4111","pred":"amod","subj":"T6732","obj":"T6731"},{"id":"R4112","pred":"compound","subj":"T6733","obj":"T6734"},{"id":"R4113","pred":"compound","subj":"T6734","obj":"T6731"},{"id":"R4114","pred":"prep","subj":"T6736","obj":"T6731"},{"id":"R4115","pred":"pobj","subj":"T6737","obj":"T6736"},{"id":"R4116","pred":"acl","subj":"T6738","obj":"T6737"},{"id":"R4117","pred":"compound","subj":"T6739","obj":"T6740"},{"id":"R4118","pred":"dobj","subj":"T6740","obj":"T6738"},{"id":"R4119","pred":"aux","subj":"T6741","obj":"T6735"},{"id":"R4120","pred":"prep","subj":"T6742","obj":"T6735"},{"id":"R4121","pred":"pcomp","subj":"T6743","obj":"T6742"},{"id":"R4122","pred":"pobj","subj":"T6744","obj":"T6742"},{"id":"R4123","pred":"prep","subj":"T6745","obj":"T6744"},{"id":"R4124","pred":"det","subj":"T6746","obj":"T6747"},{"id":"R4125","pred":"pobj","subj":"T6747","obj":"T6745"},{"id":"R4126","pred":"compound","subj":"T6748","obj":"T6747"},{"id":"R4127","pred":"punct","subj":"T6749","obj":"T6735"},{"id":"R4128","pred":"mark","subj":"T6751","obj":"T6752"},{"id":"R4129","pred":"advcl","subj":"T6752","obj":"T6761"},{"id":"R4130","pred":"det","subj":"T6753","obj":"T6754"},{"id":"R4131","pred":"nsubjpass","subj":"T6754","obj":"T6752"},{"id":"R4132","pred":"amod","subj":"T6755","obj":"T6754"},{"id":"R4133","pred":"prep","subj":"T6756","obj":"T6754"},{"id":"R4134","pred":"compound","subj":"T6757","obj":"T6758"},{"id":"R4135","pred":"pobj","subj":"T6758","obj":"T6756"},{"id":"R4136","pred":"punct","subj":"T6759","obj":"T6758"},{"id":"R4137","pred":"auxpass","subj":"T6760","obj":"T6752"},{"id":"R4138","pred":"prt","subj":"T6762","obj":"T6752"},{"id":"R4139","pred":"punct","subj":"T6763","obj":"T6761"},{"id":"R4140","pred":"det","subj":"T6764","obj":"T6765"},{"id":"R4141","pred":"nsubjpass","subj":"T6765","obj":"T6761"},{"id":"R4142","pred":"aux","subj":"T6766","obj":"T6761"},{"id":"R4143","pred":"auxpass","subj":"T6767","obj":"T6761"},{"id":"R4144","pred":"agent","subj":"T6768","obj":"T6761"},{"id":"R4145","pred":"poss","subj":"T6769","obj":"T6770"},{"id":"R4146","pred":"pobj","subj":"T6770","obj":"T6768"},{"id":"R4147","pred":"case","subj":"T6771","obj":"T6769"},{"id":"R4148","pred":"npadvmod","subj":"T6772","obj":"T6773"},{"id":"R4149","pred":"amod","subj":"T6773","obj":"T6770"},{"id":"R4150","pred":"punct","subj":"T6774","obj":"T6773"},{"id":"R4151","pred":"punct","subj":"T6775","obj":"T6761"}],"text":"Conclusions\nIn this paper we report the presence of both annexin A7 isoforms in red blood cells where they are abundant in nanovesicles that form upon Ca2+ addition. The proteins are however not required for the vesiculation process. They are also not essential for the formation of specific membrane domains such as lipid rafts, as exogenously added recombinant annexin A7 redistributed to similar positions in a density gradient containing membranes derived from red blood cells of anxA7-/-mice. The observed cell shape change of erythrocytes lacking annexin A7 might be due to alterations in the erythrocyte cytoskeleton. As a direct interaction with F-actin was ruled out, this effect might be mediated by annexin's Ca2+-binding activity."}
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T6590","span":{"begin":57,"end":67},"obj":"PR:000004080"},{"id":"T6591","span":{"begin":68,"end":76},"obj":"SO:0001060"},{"id":"T6592","span":{"begin":80,"end":95},"obj":"CL:0000232"},{"id":"T6593","span":{"begin":84,"end":89},"obj":"UBERON:0000178"},{"id":"T6594","span":{"begin":127,"end":135},"obj":"GO:0031982"},{"id":"T6595","span":{"begin":151,"end":155},"obj":"CHEBI:29108"},{"id":"T6596","span":{"begin":212,"end":224},"obj":"GO:0006900"},{"id":"T6597","span":{"begin":292,"end":308},"obj":"GO:0044425"},{"id":"T6598","span":{"begin":317,"end":322},"obj":"CHEBI:18059"},{"id":"T6599","span":{"begin":317,"end":328},"obj":"GO:0045121"},{"id":"T6600","span":{"begin":363,"end":373},"obj":"PR:000004080"},{"id":"T6601","span":{"begin":442,"end":451},"obj":"GO:0016020"},{"id":"T6602","span":{"begin":465,"end":480},"obj":"CL:0000232"},{"id":"T6603","span":{"begin":469,"end":474},"obj":"UBERON:0000178"},{"id":"T6604","span":{"begin":484,"end":489},"obj":"PR:000004080"},{"id":"T6605","span":{"begin":492,"end":496},"obj":"NCBITaxon:10088"},{"id":"T6606","span":{"begin":532,"end":544},"obj":"CL:0000232"},{"id":"T6607","span":{"begin":553,"end":563},"obj":"PR:000004080"},{"id":"T6608","span":{"begin":599,"end":610},"obj":"CL:0000232"},{"id":"T6609","span":{"begin":611,"end":623},"obj":"GO:0005856"},{"id":"T6610","span":{"begin":654,"end":661},"obj":"GO:0031941"},{"id":"T6611","span":{"begin":720,"end":724},"obj":"CHEBI:29108"}],"text":"Conclusions\nIn this paper we report the presence of both annexin A7 isoforms in red blood cells where they are abundant in nanovesicles that form upon Ca2+ addition. The proteins are however not required for the vesiculation process. They are also not essential for the formation of specific membrane domains such as lipid rafts, as exogenously added recombinant annexin A7 redistributed to similar positions in a density gradient containing membranes derived from red blood cells of anxA7-/-mice. The observed cell shape change of erythrocytes lacking annexin A7 might be due to alterations in the erythrocyte cytoskeleton. As a direct interaction with F-actin was ruled out, this effect might be mediated by annexin's Ca2+-binding activity."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6612","span":{"begin":57,"end":67},"obj":"PR_EXT:000004080"},{"id":"T6613","span":{"begin":68,"end":76},"obj":"SO_EXT:0001060"},{"id":"T6614","span":{"begin":80,"end":95},"obj":"CL:0000232"},{"id":"T6615","span":{"begin":84,"end":89},"obj":"UBERON:0000178"},{"id":"T6616","span":{"begin":90,"end":95},"obj":"CL_GO_EXT:cell"},{"id":"T6617","span":{"begin":127,"end":135},"obj":"GO:0031982"},{"id":"T6618","span":{"begin":151,"end":155},"obj":"CHEBI:29108"},{"id":"T6619","span":{"begin":170,"end":178},"obj":"CHEBI_PR_EXT:protein"},{"id":"T6620","span":{"begin":212,"end":224},"obj":"GO:0006900"},{"id":"T6621","span":{"begin":292,"end":308},"obj":"GO:0044425"},{"id":"T6622","span":{"begin":317,"end":322},"obj":"CHEBI:18059"},{"id":"T6623","span":{"begin":317,"end":328},"obj":"GO:0045121"},{"id":"T6624","span":{"begin":351,"end":362},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T6625","span":{"begin":363,"end":373},"obj":"PR_EXT:000004080"},{"id":"T6626","span":{"begin":442,"end":451},"obj":"GO:0016020"},{"id":"T6627","span":{"begin":465,"end":480},"obj":"CL:0000232"},{"id":"T6628","span":{"begin":469,"end":474},"obj":"UBERON:0000178"},{"id":"T6629","span":{"begin":475,"end":480},"obj":"CL_GO_EXT:cell"},{"id":"T6630","span":{"begin":484,"end":489},"obj":"PR_EXT:000004080"},{"id":"T6631","span":{"begin":489,"end":490},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6632","span":{"begin":491,"end":492},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6633","span":{"begin":492,"end":496},"obj":"NCBITaxon:10088"},{"id":"T6634","span":{"begin":511,"end":515},"obj":"CL_GO_EXT:cell"},{"id":"T6635","span":{"begin":532,"end":544},"obj":"CL:0000232"},{"id":"T6636","span":{"begin":553,"end":563},"obj":"PR_EXT:000004080"},{"id":"T6637","span":{"begin":599,"end":610},"obj":"CL:0000232"},{"id":"T6638","span":{"begin":611,"end":623},"obj":"GO:0005856"},{"id":"T6639","span":{"begin":654,"end":661},"obj":"GO:0031941"},{"id":"T6640","span":{"begin":710,"end":717},"obj":"PR_EXT:annexin"},{"id":"T6641","span":{"begin":720,"end":724},"obj":"CHEBI:29108"},{"id":"T6642","span":{"begin":725,"end":732},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"}],"text":"Conclusions\nIn this paper we report the presence of both annexin A7 isoforms in red blood cells where they are abundant in nanovesicles that form upon Ca2+ addition. The proteins are however not required for the vesiculation process. They are also not essential for the formation of specific membrane domains such as lipid rafts, as exogenously added recombinant annexin A7 redistributed to similar positions in a density gradient containing membranes derived from red blood cells of anxA7-/-mice. The observed cell shape change of erythrocytes lacking annexin A7 might be due to alterations in the erythrocyte cytoskeleton. As a direct interaction with F-actin was ruled out, this effect might be mediated by annexin's Ca2+-binding activity."}