Id |
Subject |
Object |
Predicate |
Lexical cue |
T6281 |
0-2 |
IN |
denotes |
As |
T6282 |
3-12 |
VBN |
denotes |
discussed |
T6283 |
39-47 |
VBN |
denotes |
involved |
T6284 |
13-18 |
RB |
denotes |
above |
T6285 |
19-26 |
NN |
denotes |
annexin |
T6286 |
27-29 |
NN |
denotes |
A7 |
T6287 |
30-35 |
MD |
denotes |
could |
T6288 |
36-38 |
VB |
denotes |
be |
T6289 |
48-50 |
IN |
denotes |
in |
T6290 |
51-54 |
DT |
denotes |
the |
T6291 |
72-83 |
NN |
denotes |
homeostasis |
T6292 |
55-66 |
JJ |
denotes |
cytoplasmic |
T6293 |
67-71 |
NN |
denotes |
Ca2+ |
T6294 |
83-84 |
. |
denotes |
. |
T6295 |
84-276 |
sentence |
denotes |
It has been demonstrated that micromolar changes of the intracellular Ca2+ concentration exert a profound effect on the membrane properties that regulate red blood cell deformability [48,49]. |
T6296 |
85-87 |
PRP |
denotes |
It |
T6297 |
97-109 |
VBN |
denotes |
demonstrated |
T6298 |
88-91 |
VBZ |
denotes |
has |
T6299 |
92-96 |
VBN |
denotes |
been |
T6300 |
110-114 |
IN |
denotes |
that |
T6301 |
174-179 |
VBP |
denotes |
exert |
T6302 |
115-125 |
JJ |
denotes |
micromolar |
T6303 |
126-133 |
NNS |
denotes |
changes |
T6304 |
134-136 |
IN |
denotes |
of |
T6305 |
137-140 |
DT |
denotes |
the |
T6306 |
160-173 |
NN |
denotes |
concentration |
T6307 |
141-154 |
JJ |
denotes |
intracellular |
T6308 |
155-159 |
NN |
denotes |
Ca2+ |
T6309 |
180-181 |
DT |
denotes |
a |
T6310 |
191-197 |
NN |
denotes |
effect |
T6311 |
182-190 |
JJ |
denotes |
profound |
T6312 |
198-200 |
IN |
denotes |
on |
T6313 |
201-204 |
DT |
denotes |
the |
T6314 |
214-224 |
NNS |
denotes |
properties |
T6315 |
205-213 |
NN |
denotes |
membrane |
T6316 |
225-229 |
WDT |
denotes |
that |
T6317 |
230-238 |
VBP |
denotes |
regulate |
T6318 |
239-242 |
JJ |
denotes |
red |
T6319 |
249-253 |
NN |
denotes |
cell |
T6320 |
243-248 |
NN |
denotes |
blood |
T6321 |
254-267 |
NN |
denotes |
deformability |
T6322 |
268-269 |
-LRB- |
denotes |
[ |
T6323 |
272-274 |
CD |
denotes |
49 |
T6324 |
269-271 |
CD |
denotes |
48 |
T6325 |
271-272 |
, |
denotes |
, |
T6326 |
274-275 |
-RRB- |
denotes |
] |
T6327 |
275-276 |
. |
denotes |
. |
T6328 |
276-419 |
sentence |
denotes |
Furthermore, the intracellular Ca2+ was shown to regulate the membrane stability through modulation of cytoskeletal protein interactions [50]. |
T6329 |
277-288 |
RB |
denotes |
Furthermore |
T6330 |
317-322 |
VBN |
denotes |
shown |
T6331 |
288-290 |
, |
denotes |
, |
T6332 |
290-293 |
DT |
denotes |
the |
T6333 |
308-312 |
NN |
denotes |
Ca2+ |
T6334 |
294-307 |
JJ |
denotes |
intracellular |
T6335 |
313-316 |
VBD |
denotes |
was |
T6336 |
323-325 |
TO |
denotes |
to |
T6337 |
326-334 |
VB |
denotes |
regulate |
T6338 |
335-338 |
DT |
denotes |
the |
T6339 |
348-357 |
NN |
denotes |
stability |
T6340 |
339-347 |
NN |
denotes |
membrane |
T6341 |
358-365 |
IN |
denotes |
through |
T6342 |
366-376 |
NN |
denotes |
modulation |
T6343 |
377-379 |
IN |
denotes |
of |
T6344 |
380-392 |
JJ |
denotes |
cytoskeletal |
T6345 |
393-400 |
NN |
denotes |
protein |
T6346 |
401-413 |
NNS |
denotes |
interactions |
T6347 |
414-415 |
-LRB- |
denotes |
[ |
T6348 |
415-417 |
CD |
denotes |
50 |
T6349 |
417-418 |
-RRB- |
denotes |
] |
T6350 |
418-419 |
. |
denotes |
. |
T6351 |
419-529 |
sentence |
denotes |
Ca2+ also induces a transbilayer phospholipid redistribution inducing a shape change of red blood cells [51]. |
T6352 |
420-424 |
NN |
denotes |
Ca2+ |
T6353 |
430-437 |
VBZ |
denotes |
induces |
T6354 |
425-429 |
RB |
denotes |
also |
T6355 |
438-439 |
DT |
denotes |
a |
T6356 |
466-480 |
NN |
denotes |
redistribution |
T6357 |
440-452 |
NN |
denotes |
transbilayer |
T6358 |
453-465 |
NN |
denotes |
phospholipid |
T6359 |
481-489 |
VBG |
denotes |
inducing |
T6360 |
490-491 |
DT |
denotes |
a |
T6361 |
498-504 |
NN |
denotes |
change |
T6362 |
492-497 |
NN |
denotes |
shape |
T6363 |
505-507 |
IN |
denotes |
of |
T6364 |
508-511 |
JJ |
denotes |
red |
T6365 |
518-523 |
NNS |
denotes |
cells |
T6366 |
512-517 |
NN |
denotes |
blood |
T6367 |
524-525 |
-LRB- |
denotes |
[ |
T6368 |
525-527 |
CD |
denotes |
51 |
T6369 |
527-528 |
-RRB- |
denotes |
] |
T6370 |
528-529 |
. |
denotes |
. |
T6371 |
529-639 |
sentence |
denotes |
In addition, Ca2+ ions can drive spiculation of the membrane bilayer without involving the cytoskeleton [52]. |
T6372 |
530-532 |
IN |
denotes |
In |
T6373 |
557-562 |
VB |
denotes |
drive |
T6374 |
533-541 |
NN |
denotes |
addition |
T6375 |
541-543 |
, |
denotes |
, |
T6376 |
543-547 |
NN |
denotes |
Ca2+ |
T6377 |
548-552 |
NNS |
denotes |
ions |
T6378 |
553-556 |
MD |
denotes |
can |
T6379 |
563-574 |
NN |
denotes |
spiculation |
T6380 |
575-577 |
IN |
denotes |
of |
T6381 |
578-581 |
DT |
denotes |
the |
T6382 |
591-598 |
NN |
denotes |
bilayer |
T6383 |
582-590 |
NN |
denotes |
membrane |
T6384 |
599-606 |
IN |
denotes |
without |
T6385 |
607-616 |
VBG |
denotes |
involving |
T6386 |
617-620 |
DT |
denotes |
the |
T6387 |
621-633 |
NN |
denotes |
cytoskeleton |
T6388 |
634-635 |
-LRB- |
denotes |
[ |
T6389 |
635-637 |
CD |
denotes |
52 |
T6390 |
637-638 |
-RRB- |
denotes |
] |
T6391 |
638-639 |
. |
denotes |
. |
R3734 |
T6344 |
T6345 |
amod |
cytoskeletal,protein |
R3736 |
T6345 |
T6346 |
compound |
protein,interactions |
R3737 |
T6346 |
T6343 |
pobj |
interactions,of |
R3738 |
T6347 |
T6348 |
punct |
[,50 |
R3739 |
T6348 |
T6330 |
parataxis |
50,shown |
R3740 |
T6349 |
T6348 |
punct |
],50 |
R3741 |
T6350 |
T6330 |
punct |
.,shown |
R3743 |
T6352 |
T6353 |
nsubj |
Ca2+,induces |
R3745 |
T6354 |
T6353 |
advmod |
also,induces |
R3746 |
T6355 |
T6356 |
det |
a,redistribution |
R3747 |
T6356 |
T6353 |
dobj |
redistribution,induces |
R3749 |
T6357 |
T6356 |
compound |
transbilayer,redistribution |
R3750 |
T6358 |
T6356 |
compound |
phospholipid,redistribution |
R3752 |
T6359 |
T6356 |
acl |
inducing,redistribution |
R3753 |
T6360 |
T6361 |
det |
a,change |
R3754 |
T6361 |
T6359 |
dobj |
change,inducing |
R3756 |
T6362 |
T6361 |
compound |
shape,change |
R3757 |
T6363 |
T6361 |
prep |
of,change |
R3759 |
T6364 |
T6365 |
amod |
red,cells |
R3760 |
T6365 |
T6363 |
pobj |
cells,of |
R3761 |
T6366 |
T6365 |
compound |
blood,cells |
R3763 |
T6367 |
T6368 |
punct |
[,51 |
R3764 |
T6368 |
T6353 |
parataxis |
51,induces |
R3765 |
T6369 |
T6368 |
punct |
],51 |
R3767 |
T6370 |
T6353 |
punct |
.,induces |
R3768 |
T6372 |
T6373 |
prep |
In,drive |
R3770 |
T6374 |
T6372 |
pobj |
addition,In |
R3772 |
T6375 |
T6373 |
punct |
", ",drive |
R3773 |
T6376 |
T6377 |
compound |
Ca2+,ions |
R3774 |
T6377 |
T6373 |
nsubj |
ions,drive |
R3776 |
T6378 |
T6373 |
aux |
can,drive |
R3777 |
T6379 |
T6373 |
dobj |
spiculation,drive |
R3778 |
T6380 |
T6379 |
prep |
of,spiculation |
R3779 |
T6381 |
T6382 |
det |
the,bilayer |
R3781 |
T6382 |
T6380 |
pobj |
bilayer,of |
R3782 |
T6383 |
T6382 |
compound |
membrane,bilayer |
R3784 |
T6384 |
T6373 |
prep |
without,drive |
R3785 |
T6385 |
T6384 |
pcomp |
involving,without |
R3786 |
T6386 |
T6387 |
det |
the,cytoskeleton |
R3788 |
T6387 |
T6385 |
dobj |
cytoskeleton,involving |
R3789 |
T6388 |
T6389 |
punct |
[,52 |
R3790 |
T6389 |
T6373 |
parataxis |
52,drive |
R3791 |
T6390 |
T6389 |
punct |
],52 |
R3792 |
T6391 |
T6373 |
punct |
.,drive |
R3841 |
T6281 |
T6282 |
mark |
As,discussed |
R3847 |
T6282 |
T6283 |
advcl |
discussed,involved |
R3851 |
T6284 |
T6282 |
advmod |
above,discussed |
R3856 |
T6285 |
T6286 |
compound |
annexin,A7 |
R3860 |
T6286 |
T6283 |
nsubjpass |
A7,involved |
R3863 |
T6287 |
T6283 |
aux |
could,involved |
R3864 |
T6288 |
T6283 |
auxpass |
be,involved |
R3865 |
T6289 |
T6283 |
prep |
in,involved |
R3866 |
T6290 |
T6291 |
det |
the,homeostasis |
R3867 |
T6291 |
T6289 |
pobj |
homeostasis,in |
R3868 |
T6292 |
T6293 |
amod |
cytoplasmic,Ca2+ |
R3870 |
T6293 |
T6291 |
compound |
Ca2+,homeostasis |
R3873 |
T6294 |
T6283 |
punct |
.,involved |
R3876 |
T6296 |
T6297 |
nsubjpass |
It,demonstrated |
R3881 |
T6298 |
T6297 |
aux |
has,demonstrated |
R3886 |
T6299 |
T6297 |
auxpass |
been,demonstrated |
R3889 |
T6300 |
T6301 |
mark |
that,exert |
R3893 |
T6301 |
T6297 |
ccomp |
exert,demonstrated |
R3900 |
T6302 |
T6303 |
amod |
micromolar,changes |
R3904 |
T6303 |
T6301 |
nsubj |
changes,exert |
R3906 |
T6304 |
T6303 |
prep |
of,changes |
R3910 |
T6305 |
T6306 |
det |
the,concentration |
R3912 |
T6306 |
T6304 |
pobj |
concentration,of |
R3915 |
T6307 |
T6306 |
amod |
intracellular,concentration |
R3917 |
T6308 |
T6306 |
compound |
Ca2+,concentration |
R3919 |
T6309 |
T6310 |
det |
a,effect |
R3922 |
T6310 |
T6301 |
dobj |
effect,exert |
R3927 |
T6311 |
T6310 |
amod |
profound,effect |
R3930 |
T6312 |
T6310 |
prep |
on,effect |
R3933 |
T6313 |
T6314 |
det |
the,properties |
R3937 |
T6314 |
T6312 |
pobj |
properties,on |
R3940 |
T6315 |
T6314 |
compound |
membrane,properties |
R3944 |
T6316 |
T6317 |
dep |
that,regulate |
R3949 |
T6317 |
T6314 |
relcl |
regulate,properties |
R3953 |
T6318 |
T6319 |
amod |
red,cell |
R3957 |
T6319 |
T6321 |
compound |
cell,deformability |
R3960 |
T6320 |
T6319 |
compound |
blood,cell |
R3964 |
T6321 |
T6317 |
dobj |
deformability,regulate |
R3967 |
T6322 |
T6323 |
punct |
[,49 |
R3971 |
T6323 |
T6297 |
parataxis |
49,demonstrated |
R3974 |
T6324 |
T6323 |
nummod |
48,49 |
R3979 |
T6325 |
T6323 |
punct |
",",49 |
R3982 |
T6326 |
T6323 |
punct |
],49 |
R3986 |
T6327 |
T6297 |
punct |
.,demonstrated |
R3989 |
T6329 |
T6330 |
advmod |
Furthermore,shown |
R3993 |
T6331 |
T6330 |
punct |
", ",shown |
R4001 |
T6332 |
T6333 |
det |
the,Ca2+ |
R4005 |
T6333 |
T6330 |
nsubjpass |
Ca2+,shown |
R4006 |
T6334 |
T6333 |
amod |
intracellular,Ca2+ |
R4007 |
T6335 |
T6330 |
auxpass |
was,shown |
R4010 |
T6336 |
T6337 |
aux |
to,regulate |
R4013 |
T6337 |
T6330 |
xcomp |
regulate,shown |
R4017 |
T6338 |
T6339 |
det |
the,stability |
R4021 |
T6339 |
T6337 |
dobj |
stability,regulate |
R4024 |
T6340 |
T6339 |
compound |
membrane,stability |
R4025 |
T6341 |
T6337 |
prep |
through,regulate |
R4026 |
T6342 |
T6341 |
pobj |
modulation,through |
R4027 |
T6343 |
T6342 |
prep |
of,modulation |