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Id Subject Object Predicate Lexical cue
T5213 11-18 NN denotes Annexin
T5214 19-21 NN denotes A7
T5215 25-32 VBN denotes thought
T5216 22-24 VBZ denotes is
T5217 33-35 TO denotes to
T5218 36-40 VB denotes have
T5219 41-42 DT denotes a
T5220 43-47 NN denotes role
T5221 48-50 IN denotes in
T5222 51-58 NN denotes vesicle
T5223 59-65 NN denotes fusion
T5224 66-69 CC denotes and
T5225 70-72 IN denotes in
T5226 73-83 VBG denotes regulating
T5227 84-87 CC denotes and
T5228 88-99 VBG denotes stabilizing
T5229 100-108 NN denotes membrane
T5230 109-116 NNS denotes domains
T5231 117-118 -LRB- denotes [
T5232 118-119 CD denotes 1
T5233 119-120 -RRB- denotes ]
T5234 120-121 . denotes .
T5235 121-301 sentence denotes The protein has been localized to the plasma membrane including raft subdomains, furthermore it is present in the cytosol where it is found on subcellular vesicle-like structures.
T5236 122-125 DT denotes The
T5237 126-133 NN denotes protein
T5238 143-152 VBN denotes localized
T5239 134-137 VBZ denotes has
T5240 138-142 VBN denotes been
T5241 218-220 VBZ denotes is
T5242 153-155 IN denotes to
T5243 156-159 DT denotes the
T5244 167-175 NN denotes membrane
T5245 160-166 NN denotes plasma
T5246 176-185 VBG denotes including
T5247 186-190 NN denotes raft
T5248 191-201 NNS denotes subdomains
T5249 201-203 , denotes ,
T5250 203-214 RB denotes furthermore
T5251 215-217 PRP denotes it
T5252 221-228 JJ denotes present
T5253 229-231 IN denotes in
T5254 232-235 DT denotes the
T5255 236-243 NN denotes cytosol
T5256 244-249 WRB denotes where
T5257 256-261 VBN denotes found
T5258 250-252 PRP denotes it
T5259 253-255 VBZ denotes is
T5260 262-264 IN denotes on
T5261 265-276 JJ denotes subcellular
T5262 290-300 NNS denotes structures
T5263 277-284 NN denotes vesicle
T5264 285-289 JJ denotes like
T5265 284-285 HYPH denotes -
T5266 300-301 . denotes .
T5267 301-382 sentence denotes This distribution appears to be independent of the tissue or cell type analysed.
T5268 302-306 DT denotes This
T5269 307-319 NN denotes distribution
T5270 320-327 VBZ denotes appears
T5271 328-330 TO denotes to
T5272 331-333 VB denotes be
T5273 334-345 JJ denotes independent
T5274 346-348 IN denotes of
T5275 349-352 DT denotes the
T5276 368-372 NN denotes type
T5277 353-359 NN denotes tissue
T5278 360-362 CC denotes or
T5279 363-367 NN denotes cell
T5280 373-381 VBN denotes analysed
T5281 381-382 . denotes .
T5282 382-536 sentence denotes In specialized or terminally differentiated cells, expression levels increase and frequently the larger of the two isoforms is being expressed [6,34,35].
T5283 383-385 IN denotes In
T5284 452-460 VBP denotes increase
T5285 386-397 VBN denotes specialized
T5286 427-432 NNS denotes cells
T5287 398-400 CC denotes or
T5288 401-411 RB denotes terminally
T5289 412-426 VBN denotes differentiated
T5290 432-434 , denotes ,
T5291 434-444 NN denotes expression
T5292 445-451 NNS denotes levels
T5293 461-464 CC denotes and
T5294 465-475 RB denotes frequently
T5295 516-525 VBN denotes expressed
T5296 476-479 DT denotes the
T5297 480-486 JJR denotes larger
T5298 487-489 IN denotes of
T5299 490-493 DT denotes the
T5300 498-506 NNS denotes isoforms
T5301 494-497 CD denotes two
T5302 507-509 VBZ denotes is
T5303 510-515 VBG denotes being
T5304 526-527 -LRB- denotes [
T5305 532-534 CD denotes 35
T5306 527-528 CD denotes 6
T5307 528-529 , denotes ,
T5308 529-531 CD denotes 34
T5309 531-532 , denotes ,
T5310 534-535 -RRB- denotes ]
T5311 535-536 . denotes .
T5312 536-695 sentence denotes Red blood cells, which were thought to be devoid of annexin A7, were recently shown to harbor the 47 kDa isoform together with its binding partner sorcin [7].
T5313 537-540 JJ denotes Red
T5314 547-552 NNS denotes cells
T5315 541-546 NN denotes blood
T5316 615-620 VBN denotes shown
T5317 552-554 , denotes ,
T5318 554-559 WDT denotes which
T5319 565-572 VBN denotes thought
T5320 560-564 VBD denotes were
T5321 573-575 TO denotes to
T5322 576-578 VB denotes be
T5323 579-585 JJ denotes devoid
T5324 586-588 IN denotes of
T5325 589-596 NN denotes annexin
T5326 597-599 NN denotes A7
T5327 599-601 , denotes ,
T5328 601-605 VBD denotes were
T5329 606-614 RB denotes recently
T5330 621-623 TO denotes to
T5331 624-630 VB denotes harbor
T5332 631-634 DT denotes the
T5333 642-649 NN denotes isoform
T5334 635-637 CD denotes 47
T5335 638-641 NN denotes kDa
T5336 650-658 RB denotes together
T5337 659-663 IN denotes with
T5338 664-667 PRP$ denotes its
T5339 676-683 NN denotes partner
T5340 668-675 VBG denotes binding
T5341 684-690 NN denotes sorcin
T5342 691-692 -LRB- denotes [
T5343 692-693 CD denotes 7
T5344 693-694 -RRB- denotes ]
T5345 694-695 . denotes .
T5346 695-819 sentence denotes We showed the presence of the 51 kDa isoform as well, adding red blood cells to the list of cells that harbor this isoform.
T5347 696-698 PRP denotes We
T5348 699-705 VBD denotes showed
T5349 706-709 DT denotes the
T5350 710-718 NN denotes presence
T5351 719-721 IN denotes of
T5352 722-725 DT denotes the
T5353 733-740 NN denotes isoform
T5354 726-728 CD denotes 51
T5355 729-732 NN denotes kDa
T5356 741-743 RB denotes as
T5357 744-748 RB denotes well
T5358 748-750 , denotes ,
T5359 750-756 VBG denotes adding
T5360 757-760 JJ denotes red
T5361 767-772 NNS denotes cells
T5362 761-766 NN denotes blood
T5363 773-775 IN denotes to
T5364 776-779 DT denotes the
T5365 780-784 NN denotes list
T5366 785-787 IN denotes of
T5367 788-793 NNS denotes cells
T5368 794-798 WDT denotes that
T5369 799-805 VBP denotes harbor
T5370 806-810 DT denotes this
T5371 811-818 NN denotes isoform
T5372 818-819 . denotes .
T5373 819-1043 sentence denotes Salzer et al. [7] not only demonstrated the presence of annexin A7 in red blood cells, they also showed that annexin A7 and sorcin were enriched in membrane raft domains of nanovesicles formed from red blood cells in vitro.
T5374 820-826 NNP denotes Salzer
T5375 917-923 VBD denotes showed
T5376 827-829 FW denotes et
T5377 830-833 FW denotes al.
T5378 834-835 -LRB- denotes [
T5379 835-836 CD denotes 7
T5380 836-837 -RRB- denotes ]
T5381 838-841 RB denotes not
T5382 842-846 RB denotes only
T5383 847-859 VBD denotes demonstrated
T5384 860-863 DT denotes the
T5385 864-872 NN denotes presence
T5386 873-875 IN denotes of
T5387 876-883 NN denotes annexin
T5388 884-886 NN denotes A7
T5389 887-889 IN denotes in
T5390 890-893 JJ denotes red
T5391 900-905 NNS denotes cells
T5392 894-899 NN denotes blood
T5393 905-907 , denotes ,
T5394 907-911 PRP denotes they
T5395 912-916 RB denotes also
T5396 924-928 IN denotes that
T5397 951-955 VBD denotes were
T5398 929-936 NN denotes annexin
T5399 937-939 NN denotes A7
T5400 940-943 CC denotes and
T5401 944-950 NN denotes sorcin
T5402 956-964 JJ denotes enriched
T5403 965-967 IN denotes in
T5404 968-976 NN denotes membrane
T5405 977-981 NN denotes raft
T5406 982-989 NNS denotes domains
T5407 990-992 IN denotes of
T5408 993-1005 NNS denotes nanovesicles
T5409 1006-1012 VBN denotes formed
T5410 1013-1017 IN denotes from
T5411 1018-1021 JJ denotes red
T5412 1028-1033 NNS denotes cells
T5413 1022-1027 NN denotes blood
T5414 1034-1036 FW denotes in
T5415 1037-1042 FW denotes vitro
T5416 1042-1043 . denotes .
T5417 1043-1162 sentence denotes Raft domains in general are considered key players in membrane organization and in mediating the vesiculation process.
T5418 1044-1048 NN denotes Raft
T5419 1049-1056 NNS denotes domains
T5420 1072-1082 VBN denotes considered
T5421 1057-1059 IN denotes in
T5422 1060-1067 JJ denotes general
T5423 1068-1071 VBP denotes are
T5424 1083-1086 JJ denotes key
T5425 1087-1094 NNS denotes players
T5426 1095-1097 IN denotes in
T5427 1098-1106 NN denotes membrane
T5428 1107-1119 NN denotes organization
T5429 1120-1123 CC denotes and
T5430 1124-1126 IN denotes in
T5431 1127-1136 VBG denotes mediating
T5432 1137-1140 DT denotes the
T5433 1154-1161 NN denotes process
T5434 1141-1153 NN denotes vesiculation
T5435 1161-1162 . denotes .
T5436 1162-1366 sentence denotes They result from the clustering of sphingolipids and cholesterol in the outer leaflet of the membrane connected to phospholipids and cholesterol in the inner leaflet and are enriched in special proteins.
T5437 1163-1167 PRP denotes They
T5438 1168-1174 VBP denotes result
T5439 1175-1179 IN denotes from
T5440 1180-1183 DT denotes the
T5441 1184-1194 NN denotes clustering
T5442 1195-1197 IN denotes of
T5443 1198-1211 NNS denotes sphingolipids
T5444 1212-1215 CC denotes and
T5445 1216-1227 NN denotes cholesterol
T5446 1228-1230 IN denotes in
T5447 1231-1234 DT denotes the
T5448 1241-1248 NN denotes leaflet
T5449 1235-1240 JJ denotes outer
T5450 1249-1251 IN denotes of
T5451 1252-1255 DT denotes the
T5452 1256-1264 NN denotes membrane
T5453 1265-1274 VBN denotes connected
T5454 1275-1277 IN denotes to
T5455 1278-1291 NNS denotes phospholipids
T5456 1292-1295 CC denotes and
T5457 1296-1307 NN denotes cholesterol
T5458 1308-1310 IN denotes in
T5459 1311-1314 DT denotes the
T5460 1321-1328 NN denotes leaflet
T5461 1315-1320 JJ denotes inner
T5462 1329-1332 CC denotes and
T5463 1333-1336 VBP denotes are
T5464 1337-1345 JJ denotes enriched
T5465 1346-1348 IN denotes in
T5466 1349-1356 JJ denotes special
T5467 1357-1365 NN denotes proteins
T5468 1365-1366 . denotes .
T5469 1366-1542 sentence denotes Biochemically rafts are defined as membranes that are resistant to extraction by cold Triton X-100 and can be floated to low densities in sucrose gradient centrifugation [36].
T5470 1367-1380 RB denotes Biochemically
T5471 1391-1398 VBN denotes defined
T5472 1381-1386 NNS denotes rafts
T5473 1387-1390 VBP denotes are
T5474 1399-1401 IN denotes as
T5475 1402-1411 NNS denotes membranes
T5476 1412-1416 WDT denotes that
T5477 1417-1420 VBP denotes are
T5478 1421-1430 JJ denotes resistant
T5479 1431-1433 IN denotes to
T5480 1434-1444 NN denotes extraction
T5481 1445-1447 IN denotes by
T5482 1448-1452 JJ denotes cold
T5483 1460-1461 NN denotes X
T5484 1453-1459 NN denotes Triton
T5485 1461-1462 HYPH denotes -
T5486 1462-1465 CD denotes 100
T5487 1466-1469 CC denotes and
T5488 1470-1473 MD denotes can
T5489 1477-1484 VBN denotes floated
T5490 1474-1476 VB denotes be
T5491 1485-1487 IN denotes to
T5492 1488-1491 JJ denotes low
T5493 1492-1501 NNS denotes densities
T5494 1502-1504 IN denotes in
T5495 1505-1512 NN denotes sucrose
T5496 1513-1521 NN denotes gradient
T5497 1522-1536 NN denotes centrifugation
T5498 1537-1538 -LRB- denotes [
T5499 1538-1540 CD denotes 36
T5500 1540-1541 -RRB- denotes ]
T5501 1541-1542 . denotes .
T5502 1542-1701 sentence denotes The findings of Caohuy et al. [37] that annexin A7 mediates membrane aggregation also suggested that annexin A7 is an essential component during vesiculation.
T5503 1543-1546 DT denotes The
T5504 1547-1555 NNS denotes findings
T5505 1629-1638 VBD denotes suggested
T5506 1556-1558 IN denotes of
T5507 1559-1565 NNP denotes Caohuy
T5508 1566-1568 FW denotes et
T5509 1569-1572 FW denotes al.
T5510 1573-1574 -LRB- denotes [
T5511 1574-1576 CD denotes 37
T5512 1576-1577 -RRB- denotes ]
T5513 1578-1582 IN denotes that
T5514 1594-1602 VBZ denotes mediates
T5515 1583-1590 NN denotes annexin
T5516 1591-1593 NN denotes A7
T5517 1603-1611 NN denotes membrane
T5518 1612-1623 NN denotes aggregation
T5519 1624-1628 RB denotes also
T5520 1639-1643 IN denotes that
T5521 1655-1657 VBZ denotes is
T5522 1644-1651 NN denotes annexin
T5523 1652-1654 NN denotes A7
T5524 1658-1660 DT denotes an
T5525 1671-1680 NN denotes component
T5526 1661-1670 JJ denotes essential
T5527 1681-1687 IN denotes during
T5528 1688-1700 NN denotes vesiculation
T5529 1700-1701 . denotes .
T5530 1701-1830 sentence denotes In addition they reported a further activation of the vesiculation process by GTP and proposed that annexin A7 acts as a GTPase.
T5531 1702-1704 IN denotes In
T5532 1719-1727 VBD denotes reported
T5533 1705-1713 NN denotes addition
T5534 1714-1718 PRP denotes they
T5535 1728-1729 DT denotes a
T5536 1738-1748 NN denotes activation
T5537 1730-1737 JJ denotes further
T5538 1749-1751 IN denotes of
T5539 1752-1755 DT denotes the
T5540 1769-1776 NN denotes process
T5541 1756-1768 NN denotes vesiculation
T5542 1777-1779 IN denotes by
T5543 1780-1783 NN denotes GTP
T5544 1784-1787 CC denotes and
T5545 1788-1796 VBD denotes proposed
T5546 1797-1801 IN denotes that
T5547 1813-1817 VBZ denotes acts
T5548 1802-1809 NN denotes annexin
T5549 1810-1812 NN denotes A7
T5550 1818-1820 IN denotes as
T5551 1821-1822 DT denotes a
T5552 1823-1829 NN denotes GTPase
T5553 1829-1830 . denotes .
T5554 1830-1913 sentence denotes Similarly, the presence of GTP enhanced the secretion of surfactant by annexin A7.
T5555 1831-1840 RB denotes Similarly
T5556 1862-1870 VBD denotes enhanced
T5557 1840-1842 , denotes ,
T5558 1842-1845 DT denotes the
T5559 1846-1854 NN denotes presence
T5560 1855-1857 IN denotes of
T5561 1858-1861 NN denotes GTP
T5562 1871-1874 DT denotes the
T5563 1875-1884 NN denotes secretion
T5564 1885-1887 IN denotes of
T5565 1888-1898 NN denotes surfactant
T5566 1899-1901 IN denotes by
T5567 1902-1909 NN denotes annexin
T5568 1910-1912 NN denotes A7
T5569 1912-1913 . denotes .
T5570 1913-2120 sentence denotes These results were thought to support a direct role for annexin A7 in surfactant secretion, but in these studies annexin A7 mediated membrane fusion was separated from a second GTP-dependent mechanism [38].
T5571 1914-1919 DT denotes These
T5572 1920-1927 NNS denotes results
T5573 1933-1940 VBN denotes thought
T5574 1928-1932 VBD denotes were
T5575 1941-1943 TO denotes to
T5576 1944-1951 VB denotes support
T5577 1952-1953 DT denotes a
T5578 1961-1965 NN denotes role
T5579 1954-1960 JJ denotes direct
T5580 1966-1969 IN denotes for
T5581 1970-1977 NN denotes annexin
T5582 1978-1980 NN denotes A7
T5583 1981-1983 IN denotes in
T5584 1984-1994 JJ denotes surfactant
T5585 1995-2004 NN denotes secretion
T5586 2004-2006 , denotes ,
T5587 2006-2009 CC denotes but
T5588 2010-2012 IN denotes in
T5589 2067-2076 VBN denotes separated
T5590 2013-2018 DT denotes these
T5591 2019-2026 NNS denotes studies
T5592 2027-2034 NN denotes annexin
T5593 2035-2037 NN denotes A7
T5594 2038-2046 VBN denotes mediated
T5595 2056-2062 NN denotes fusion
T5596 2047-2055 NN denotes membrane
T5597 2063-2066 VBD denotes was
T5598 2077-2081 IN denotes from
T5599 2082-2083 DT denotes a
T5600 2105-2114 NN denotes mechanism
T5601 2084-2090 JJ denotes second
T5602 2091-2094 NN denotes GTP
T5603 2095-2104 JJ denotes dependent
T5604 2094-2095 HYPH denotes -
T5605 2115-2116 -LRB- denotes [
T5606 2116-2118 CD denotes 38
T5607 2118-2119 -RRB- denotes ]
T5608 2119-2120 . denotes .
T5609 2120-2235 sentence denotes Having an annexin A7 knockout mouse we tested the involvement of annexin A7 in budding of red blood cell vesicles.
T5610 2121-2127 VBG denotes Having
T5611 2160-2166 VBD denotes tested
T5612 2128-2130 DT denotes an
T5613 2151-2156 NN denotes mouse
T5614 2131-2138 NN denotes annexin
T5615 2139-2141 NN denotes A7
T5616 2142-2150 NN denotes knockout
T5617 2157-2159 PRP denotes we
T5618 2167-2170 DT denotes the
T5619 2171-2182 NN denotes involvement
T5620 2183-2185 IN denotes of
T5621 2186-2193 NN denotes annexin
T5622 2194-2196 NN denotes A7
T5623 2197-2199 IN denotes in
T5624 2200-2207 NN denotes budding
T5625 2208-2210 IN denotes of
T5626 2211-2214 JJ denotes red
T5627 2221-2225 NN denotes cell
T5628 2215-2220 NN denotes blood
T5629 2226-2234 NNS denotes vesicles
T5630 2234-2235 . denotes .
T5631 2235-2380 sentence denotes Our data suggest that the efficiency of micro- and nanovesicle formation is not significantly different in wild type and mutant red blood cells.
T5632 2236-2239 PRP$ denotes Our
T5633 2240-2244 NNS denotes data
T5634 2245-2252 VBP denotes suggest
T5635 2253-2257 IN denotes that
T5636 2309-2311 VBZ denotes is
T5637 2258-2261 DT denotes the
T5638 2262-2272 NN denotes efficiency
T5639 2273-2275 IN denotes of
T5640 2276-2281 AFX denotes micro
T5641 2287-2298 NN denotes nanovesicle
T5642 2281-2282 HYPH denotes -
T5643 2283-2286 CC denotes and
T5644 2299-2308 NN denotes formation
T5645 2312-2315 RB denotes not
T5646 2316-2329 RB denotes significantly
T5647 2330-2339 JJ denotes different
T5648 2340-2342 IN denotes in
T5649 2343-2347 JJ denotes wild
T5650 2348-2352 NN denotes type
T5651 2374-2379 NNS denotes cells
T5652 2353-2356 CC denotes and
T5653 2357-2363 JJ denotes mutant
T5654 2364-2367 JJ denotes red
T5655 2368-2373 NN denotes blood
T5656 2379-2380 . denotes .
T5657 2380-2559 sentence denotes Likewise, Dictyostelium discoideum cells, in which the single annexin gene was inactivated, were not impaired in processes requiring membrane fusion [[39]; and data unpublished].
T5658 2381-2389 RB denotes Likewise
T5659 2473-2477 VBD denotes were
T5660 2389-2391 , denotes ,
T5661 2391-2404 NNP denotes Dictyostelium
T5662 2405-2415 NNP denotes discoideum
T5663 2416-2421 NNS denotes cells
T5664 2421-2423 , denotes ,
T5665 2423-2425 IN denotes in
T5666 2456-2459 VBD denotes was
T5667 2426-2431 WDT denotes which
T5668 2432-2435 DT denotes the
T5669 2451-2455 NN denotes gene
T5670 2436-2442 JJ denotes single
T5671 2443-2450 NN denotes annexin
T5672 2460-2471 JJ denotes inactivated
T5673 2471-2473 , denotes ,
T5674 2478-2481 RB denotes not
T5675 2482-2490 JJ denotes impaired
T5676 2491-2493 IN denotes in
T5677 2494-2503 NNS denotes processes
T5678 2504-2513 VBG denotes requiring
T5679 2514-2522 NN denotes membrane
T5680 2523-2529 NN denotes fusion
T5681 2530-2531 -LRB- denotes [
T5682 2532-2534 CD denotes 39
T5683 2531-2532 -LRB- denotes [
T5684 2534-2535 -RRB- denotes ]
T5685 2535-2536 : denotes ;
T5686 2537-2540 CC denotes and
T5687 2541-2545 NNS denotes data
T5688 2546-2557 JJ denotes unpublished
T5689 2557-2558 -RRB- denotes ]
T5690 2558-2559 . denotes .
T5691 2559-2721 sentence denotes It might well be that the observed fusion of phospholipid layers by annexin A7 in the presence of high Ca2+ concentrations may turn out to be an in vitro effect.
T5692 2560-2562 PRP denotes It
T5693 2574-2576 VB denotes be
T5694 2563-2568 MD denotes might
T5695 2569-2573 RB denotes well
T5696 2577-2581 IN denotes that
T5697 2687-2691 VB denotes turn
T5698 2582-2585 DT denotes the
T5699 2595-2601 NN denotes fusion
T5700 2586-2594 VBN denotes observed
T5701 2602-2604 IN denotes of
T5702 2605-2617 NN denotes phospholipid
T5703 2618-2624 NNS denotes layers
T5704 2625-2627 IN denotes by
T5705 2628-2635 NN denotes annexin
T5706 2636-2638 NN denotes A7
T5707 2639-2641 IN denotes in
T5708 2642-2645 DT denotes the
T5709 2646-2654 NN denotes presence
T5710 2655-2657 IN denotes of
T5711 2658-2662 JJ denotes high
T5712 2668-2682 NNS denotes concentrations
T5713 2663-2667 NN denotes Ca2+
T5714 2683-2686 MD denotes may
T5715 2692-2695 RP denotes out
T5716 2696-2698 TO denotes to
T5717 2699-2701 VB denotes be
T5718 2702-2704 DT denotes an
T5719 2714-2720 NN denotes effect
T5720 2705-2707 FW denotes in
T5721 2708-2713 FW denotes vitro
T5722 2720-2721 . denotes .
T5723 2721-2988 sentence denotes Similarly, the high abundance of annexin A7 in micro- and nanovesicles might be fortuitous as a significant percentage of the red blood cell membrane, with which annexin A7 associates when the Ca2+ levels rise, appears to be involved in the formation of exovesicles.
T5724 2722-2731 RB denotes Similarly
T5725 2799-2801 VB denotes be
T5726 2731-2733 , denotes ,
T5727 2733-2736 DT denotes the
T5728 2742-2751 NN denotes abundance
T5729 2737-2741 JJ denotes high
T5730 2752-2754 IN denotes of
T5731 2755-2762 NN denotes annexin
T5732 2763-2765 NN denotes A7
T5733 2766-2768 IN denotes in
T5734 2769-2774 AFX denotes micro
T5735 2780-2792 NNS denotes nanovesicles
T5736 2774-2775 HYPH denotes -
T5737 2776-2779 CC denotes and
T5738 2793-2798 MD denotes might
T5739 2802-2812 JJ denotes fortuitous
T5740 2813-2815 IN denotes as
T5741 2933-2940 VBZ denotes appears
T5742 2816-2817 DT denotes a
T5743 2830-2840 NN denotes percentage
T5744 2818-2829 JJ denotes significant
T5745 2841-2843 IN denotes of
T5746 2844-2847 DT denotes the
T5747 2863-2871 NN denotes membrane
T5748 2848-2851 JJ denotes red
T5749 2858-2862 NN denotes cell
T5750 2852-2857 NN denotes blood
T5751 2871-2873 , denotes ,
T5752 2873-2877 IN denotes with
T5753 2895-2905 VBZ denotes associates
T5754 2878-2883 WDT denotes which
T5755 2884-2891 NN denotes annexin
T5756 2892-2894 NN denotes A7
T5757 2906-2910 WRB denotes when
T5758 2927-2931 VBP denotes rise
T5759 2911-2914 DT denotes the
T5760 2920-2926 NNS denotes levels
T5761 2915-2919 NN denotes Ca2+
T5762 2931-2933 , denotes ,
T5763 2941-2943 TO denotes to
T5764 2947-2955 VBN denotes involved
T5765 2944-2946 VB denotes be
T5766 2956-2958 IN denotes in
T5767 2959-2962 DT denotes the
T5768 2963-2972 NN denotes formation
T5769 2973-2975 IN denotes of
T5770 2976-2987 NNS denotes exovesicles
T5771 2987-2988 . denotes .
T5772 2988-3173 sentence denotes Furthermore, the distribution of both annexin A7 isoforms in gradients of red blood cells indicates a function which differs from organizing subcellular membranes or membrane pathways.
T5773 2989-3000 RB denotes Furthermore
T5774 3079-3088 VBZ denotes indicates
T5775 3000-3002 , denotes ,
T5776 3002-3005 DT denotes the
T5777 3006-3018 NN denotes distribution
T5778 3019-3021 IN denotes of
T5779 3022-3026 DT denotes both
T5780 3038-3046 NNS denotes isoforms
T5781 3027-3034 NN denotes annexin
T5782 3035-3037 NN denotes A7
T5783 3047-3049 IN denotes in
T5784 3050-3059 NNS denotes gradients
T5785 3060-3062 IN denotes of
T5786 3063-3066 JJ denotes red
T5787 3073-3078 NNS denotes cells
T5788 3067-3072 NN denotes blood
T5789 3089-3090 DT denotes a
T5790 3091-3099 NN denotes function
T5791 3100-3105 WDT denotes which
T5792 3106-3113 VBZ denotes differs
T5793 3114-3118 IN denotes from
T5794 3119-3129 VBG denotes organizing
T5795 3130-3141 JJ denotes subcellular
T5796 3142-3151 NNS denotes membranes
T5797 3152-3154 CC denotes or
T5798 3155-3163 NN denotes membrane
T5799 3164-3172 NNS denotes pathways
T5800 3172-3173 . denotes .
T5801 3173-3389 sentence denotes Whereas annexin A2 is tightly associated with endosomes and may have functions in membrane fusion and the endosomal pathway, annexin A7 distributes with plasma membrane raft domains of different types and densities.
T5802 3174-3181 IN denotes Whereas
T5803 3204-3214 VBN denotes associated
T5804 3182-3189 NN denotes annexin
T5805 3190-3192 NN denotes A2
T5806 3193-3195 VBZ denotes is
T5807 3196-3203 RB denotes tightly
T5808 3310-3321 VBZ denotes distributes
T5809 3215-3219 IN denotes with
T5810 3220-3229 NNS denotes endosomes
T5811 3230-3233 CC denotes and
T5812 3234-3237 MD denotes may
T5813 3238-3242 VB denotes have
T5814 3243-3252 NNS denotes functions
T5815 3253-3255 IN denotes in
T5816 3256-3264 NN denotes membrane
T5817 3265-3271 NN denotes fusion
T5818 3272-3275 CC denotes and
T5819 3276-3279 DT denotes the
T5820 3290-3297 NN denotes pathway
T5821 3280-3289 JJ denotes endosomal
T5822 3297-3299 , denotes ,
T5823 3299-3306 NN denotes annexin
T5824 3307-3309 NN denotes A7
T5825 3322-3326 IN denotes with
T5826 3327-3333 NN denotes plasma
T5827 3334-3342 NN denotes membrane
T5828 3348-3355 NNS denotes domains
T5829 3343-3347 NN denotes raft
T5830 3356-3358 IN denotes of
T5831 3359-3368 JJ denotes different
T5832 3369-3374 NNS denotes types
T5833 3375-3378 CC denotes and
T5834 3379-3388 NNS denotes densities
T5835 3388-3389 . denotes .
T5836 3389-3623 sentence denotes Interestingly, in vesicles of red blood cells lacking annexin A7 the amount of sorcin is lowered, indicating that its localisation is affected by the loss of annexin A7 or its expression during red blood cell development was reduced.
T5837 3390-3403 RB denotes Interestingly
T5838 3479-3486 VBN denotes lowered
T5839 3403-3405 , denotes ,
T5840 3405-3407 IN denotes in
T5841 3408-3416 NNS denotes vesicles
T5842 3417-3419 IN denotes of
T5843 3420-3423 JJ denotes red
T5844 3430-3435 NNS denotes cells
T5845 3424-3429 NN denotes blood
T5846 3436-3443 VBG denotes lacking
T5847 3444-3451 NN denotes annexin
T5848 3452-3454 NN denotes A7
T5849 3455-3458 DT denotes the
T5850 3459-3465 NN denotes amount
T5851 3466-3468 IN denotes of
T5852 3469-3475 NN denotes sorcin
T5853 3476-3478 VBZ denotes is
T5854 3486-3488 , denotes ,
T5855 3488-3498 VBG denotes indicating
T5856 3499-3503 IN denotes that
T5857 3524-3532 VBN denotes affected
T5858 3504-3507 PRP$ denotes its
T5859 3508-3520 NN denotes localisation
T5860 3521-3523 VBZ denotes is
T5861 3533-3535 IN denotes by
T5862 3536-3539 DT denotes the
T5863 3540-3544 NN denotes loss
T5864 3545-3547 IN denotes of
T5865 3548-3555 NN denotes annexin
T5866 3556-3558 NN denotes A7
T5867 3559-3561 CC denotes or
T5868 3562-3565 PRP$ denotes its
T5869 3566-3576 NN denotes expression
T5870 3615-3622 VBN denotes reduced
T5871 3577-3583 IN denotes during
T5872 3584-3587 JJ denotes red
T5873 3594-3598 NN denotes cell
T5874 3588-3593 NN denotes blood
T5875 3599-3610 NN denotes development
T5876 3611-3614 VBD denotes was
T5877 3622-3623 . denotes .
T5878 3623-3762 sentence denotes Having excluded a direct role in vesicle formation and membrane fusion, annexin A7 might act by its property as Ca2+-binding protein [17].
T5879 3624-3630 VBG denotes Having
T5880 3631-3639 VBN denotes excluded
T5881 3713-3716 VB denotes act
T5882 3640-3641 DT denotes a
T5883 3649-3653 NN denotes role
T5884 3642-3648 JJ denotes direct
T5885 3654-3656 IN denotes in
T5886 3657-3664 NN denotes vesicle
T5887 3665-3674 NN denotes formation
T5888 3675-3678 CC denotes and
T5889 3679-3687 NN denotes membrane
T5890 3688-3694 NN denotes fusion
T5891 3694-3696 , denotes ,
T5892 3696-3703 NN denotes annexin
T5893 3704-3706 NN denotes A7
T5894 3707-3712 MD denotes might
T5895 3717-3719 IN denotes by
T5896 3720-3723 PRP$ denotes its
T5897 3724-3732 NN denotes property
T5898 3733-3735 IN denotes as
T5899 3736-3740 NN denotes Ca2+
T5900 3741-3748 VBG denotes binding
T5901 3740-3741 HYPH denotes -
T5902 3749-3756 NN denotes protein
T5903 3757-3758 -LRB- denotes [
T5904 3758-3760 CD denotes 17
T5905 3760-3761 -RRB- denotes ]
T5906 3761-3762 . denotes .
T5907 3762-4000 sentence denotes Previous results in which annexin A7 was shown to play a role in membrane aggregation might be explained by a supportive function of annexin A7 in that it interferes with the local Ca2+ homeostasis thus influencing membrane organization.
T5908 3763-3771 JJ denotes Previous
T5909 3772-3779 NNS denotes results
T5910 3858-3867 VBN denotes explained
T5911 3780-3782 IN denotes in
T5912 3804-3809 VBN denotes shown
T5913 3783-3788 WDT denotes which
T5914 3789-3796 NN denotes annexin
T5915 3797-3799 NN denotes A7
T5916 3800-3803 VBD denotes was
T5917 3810-3812 TO denotes to
T5918 3813-3817 VB denotes play
T5919 3818-3819 DT denotes a
T5920 3820-3824 NN denotes role
T5921 3825-3827 IN denotes in
T5922 3828-3836 NN denotes membrane
T5923 3837-3848 NN denotes aggregation
T5924 3849-3854 MD denotes might
T5925 3855-3857 VB denotes be
T5926 3868-3870 IN denotes by
T5927 3871-3872 DT denotes a
T5928 3884-3892 NN denotes function
T5929 3873-3883 JJ denotes supportive
T5930 3893-3895 IN denotes of
T5931 3896-3903 NN denotes annexin
T5932 3904-3906 NN denotes A7
T5933 3907-3909 IN denotes in
T5934 3918-3928 VBZ denotes interferes
T5935 3910-3914 IN denotes that
T5936 3915-3917 PRP denotes it
T5937 3929-3933 IN denotes with
T5938 3934-3937 DT denotes the
T5939 3949-3960 NN denotes homeostasis
T5940 3938-3943 JJ denotes local
T5941 3944-3948 NN denotes Ca2+
T5942 3961-3965 RB denotes thus
T5943 3966-3977 VBG denotes influencing
T5944 3978-3986 NN denotes membrane
T5945 3987-3999 NN denotes organization
T5946 3999-4000 . denotes .
T5947 4000-4138 sentence denotes As the annexins belong to a wide spread and evolutionarily conserved protein family, redundant, but not identical functions are expected.
T5948 4001-4003 IN denotes As
T5949 4017-4023 VBP denotes belong
T5950 4004-4007 DT denotes the
T5951 4008-4016 NNS denotes annexins
T5952 4129-4137 VBN denotes expected
T5953 4024-4026 IN denotes to
T5954 4027-4028 DT denotes a
T5955 4078-4084 NN denotes family
T5956 4029-4033 RB denotes wide
T5957 4034-4040 VBN denotes spread
T5958 4041-4044 CC denotes and
T5959 4045-4059 RB denotes evolutionarily
T5960 4060-4069 VBN denotes conserved
T5961 4070-4077 NN denotes protein
T5962 4084-4086 , denotes ,
T5963 4086-4095 NN denotes redundant
T5964 4105-4114 JJ denotes identical
T5965 4095-4097 , denotes ,
T5966 4097-4100 CC denotes but
T5967 4101-4104 RB denotes not
T5968 4115-4124 NNS denotes functions
T5969 4125-4128 VBP denotes are
T5970 4137-4138 . denotes .
T5971 4138-4271 sentence denotes However, so far no other members of the annexin family, which may substitute for annexin A7, have been described in red blood cells.
T5972 4139-4146 RB denotes However
T5973 4242-4251 VBN denotes described
T5974 4146-4148 , denotes ,
T5975 4148-4150 RB denotes so
T5976 4151-4154 RB denotes far
T5977 4155-4157 DT denotes no
T5978 4164-4171 NNS denotes members
T5979 4158-4163 JJ denotes other
T5980 4172-4174 IN denotes of
T5981 4175-4178 DT denotes the
T5982 4187-4193 NN denotes family
T5983 4179-4186 NN denotes annexin
T5984 4193-4195 , denotes ,
T5985 4195-4200 WDT denotes which
T5986 4205-4215 VB denotes substitute
T5987 4201-4204 MD denotes may
T5988 4216-4219 IN denotes for
T5989 4220-4227 NN denotes annexin
T5990 4228-4230 NN denotes A7
T5991 4230-4232 , denotes ,
T5992 4232-4236 VBP denotes have
T5993 4237-4241 VBN denotes been
T5994 4252-4254 IN denotes in
T5995 4255-4258 JJ denotes red
T5996 4265-4270 NNS denotes cells
T5997 4259-4264 NN denotes blood
T5998 4270-4271 . denotes .
T5999 4271-4463 sentence denotes The structural basis for the elasticy of red blood cells in circulation are long range molecular functions of the plasma membrane and the membrane associated part of the cytoskeleton [40-43].
T6000 4272-4275 DT denotes The
T6001 4287-4292 NN denotes basis
T6002 4276-4286 JJ denotes structural
T6003 4344-4347 VBP denotes are
T6004 4293-4296 IN denotes for
T6005 4297-4300 DT denotes the
T6006 4301-4309 NN denotes elasticy
T6007 4310-4312 IN denotes of
T6008 4313-4316 JJ denotes red
T6009 4323-4328 NNS denotes cells
T6010 4317-4322 NN denotes blood
T6011 4329-4331 IN denotes in
T6012 4332-4343 NN denotes circulation
T6013 4348-4352 JJ denotes long
T6014 4353-4358 NN denotes range
T6015 4369-4378 NNS denotes functions
T6016 4359-4368 JJ denotes molecular
T6017 4379-4381 IN denotes of
T6018 4382-4385 DT denotes the
T6019 4393-4401 NN denotes membrane
T6020 4386-4392 NN denotes plasma
T6021 4402-4405 CC denotes and
T6022 4406-4409 DT denotes the
T6023 4430-4434 NN denotes part
T6024 4410-4418 NN denotes membrane
T6025 4419-4429 VBN denotes associated
T6026 4435-4437 IN denotes of
T6027 4438-4441 DT denotes the
T6028 4442-4454 NN denotes cytoskeleton
T6029 4455-4456 -LRB- denotes [
T6030 4456-4458 CD denotes 40
T6031 4458-4459 SYM denotes -
T6032 4459-4461 CD denotes 43
T6033 4461-4462 -RRB- denotes ]
T6034 4462-4463 . denotes .
T6035 4463-4675 sentence denotes Major constituents of the membrane skeleton are spectrin tetramers linked together by short actin filaments and several other proteins covering the entire cytoplasmic surface of the red blood cell membrane [44].
T6036 4464-4469 JJ denotes Major
T6037 4470-4482 NNS denotes constituents
T6038 4508-4511 VBP denotes are
T6039 4483-4485 IN denotes of
T6040 4486-4489 DT denotes the
T6041 4499-4507 NN denotes skeleton
T6042 4490-4498 NN denotes membrane
T6043 4512-4520 NN denotes spectrin
T6044 4521-4530 NNS denotes tetramers
T6045 4531-4537 VBN denotes linked
T6046 4538-4546 RB denotes together
T6047 4547-4549 IN denotes by
T6048 4550-4555 JJ denotes short
T6049 4562-4571 NNS denotes filaments
T6050 4556-4561 NN denotes actin
T6051 4572-4575 CC denotes and
T6052 4576-4583 JJ denotes several
T6053 4590-4598 NN denotes proteins
T6054 4584-4589 JJ denotes other
T6055 4599-4607 VBG denotes covering
T6056 4608-4611 DT denotes the
T6057 4631-4638 NN denotes surface
T6058 4612-4618 JJ denotes entire
T6059 4619-4630 JJ denotes cytoplasmic
T6060 4639-4641 IN denotes of
T6061 4642-4645 DT denotes the
T6062 4661-4669 NN denotes membrane
T6063 4646-4649 JJ denotes red
T6064 4656-4660 NN denotes cell
T6065 4650-4655 NN denotes blood
T6066 4670-4671 -LRB- denotes [
T6067 4671-4673 CD denotes 44
T6068 4673-4674 -RRB- denotes ]
T6069 4674-4675 . denotes .
T6070 4675-4937 sentence denotes Membrane cholesterol diminishes red blood cell haemolysis by the complement complex, whereas depletion of raft cholesterol abrogates association of all raft proteins with no significant effect on areas in the rest of the cell membrane and deformability [45,46].
T6071 4676-4684 NN denotes Membrane
T6072 4685-4696 NN denotes cholesterol
T6073 4697-4707 VBZ denotes diminishes
T6074 4708-4711 JJ denotes red
T6075 4718-4722 NN denotes cell
T6076 4712-4717 NN denotes blood
T6077 4723-4733 NN denotes haemolysis
T6078 4734-4736 IN denotes by
T6079 4737-4740 DT denotes the
T6080 4752-4759 NN denotes complex
T6081 4741-4751 NN denotes complement
T6082 4759-4761 , denotes ,
T6083 4761-4768 IN denotes whereas
T6084 4799-4808 VBZ denotes abrogates
T6085 4769-4778 NN denotes depletion
T6086 4779-4781 IN denotes of
T6087 4782-4786 NN denotes raft
T6088 4787-4798 NN denotes cholesterol
T6089 4809-4820 NN denotes association
T6090 4821-4823 IN denotes of
T6091 4824-4827 DT denotes all
T6092 4833-4841 NN denotes proteins
T6093 4828-4832 NN denotes raft
T6094 4842-4846 IN denotes with
T6095 4847-4849 DT denotes no
T6096 4862-4868 NN denotes effect
T6097 4850-4861 JJ denotes significant
T6098 4869-4871 IN denotes on
T6099 4872-4877 NNS denotes areas
T6100 4878-4880 IN denotes in
T6101 4881-4884 DT denotes the
T6102 4885-4889 NN denotes rest
T6103 4890-4892 IN denotes of
T6104 4893-4896 DT denotes the
T6105 4902-4910 NN denotes membrane
T6106 4897-4901 NN denotes cell
T6107 4911-4914 CC denotes and
T6108 4915-4928 NN denotes deformability
T6109 4929-4930 -LRB- denotes [
T6110 4933-4935 CD denotes 46
T6111 4930-4932 CD denotes 45
T6112 4932-4933 , denotes ,
T6113 4935-4936 -RRB- denotes ]
T6114 4936-4937 . denotes .
T6115 4937-5041 sentence denotes Annexin A7 knock out mouse red blood cells show a more flat shape and have a higher osmotic resistance.
T6116 4938-4945 NN denotes Annexin
T6117 4946-4948 NN denotes A7
T6118 4975-4980 NNS denotes cells
T6119 4949-4954 NN denotes knock
T6120 4955-4958 NN denotes out
T6121 4959-4964 NN denotes mouse
T6122 4965-4968 JJ denotes red
T6123 4969-4974 NN denotes blood
T6124 4981-4985 VBP denotes show
T6125 4986-4987 DT denotes a
T6126 4998-5003 NN denotes shape
T6127 4988-4992 RBR denotes more
T6128 4993-4997 JJ denotes flat
T6129 5004-5007 CC denotes and
T6130 5008-5012 VBP denotes have
T6131 5013-5014 DT denotes a
T6132 5030-5040 NN denotes resistance
T6133 5015-5021 JJR denotes higher
T6134 5022-5029 JJ denotes osmotic
T6135 5040-5041 . denotes .
T6136 5041-5209 sentence denotes The presence of annexin A7 may alter the membrane flexibility in that it supports the typical biconcave membrane shape and leads to a lower minimal osmotic resistance.
T6137 5042-5045 DT denotes The
T6138 5046-5054 NN denotes presence
T6139 5073-5078 VB denotes alter
T6140 5055-5057 IN denotes of
T6141 5058-5065 NN denotes annexin
T6142 5066-5068 NN denotes A7
T6143 5069-5072 MD denotes may
T6144 5079-5082 DT denotes the
T6145 5092-5103 NN denotes flexibility
T6146 5083-5091 NN denotes membrane
T6147 5104-5106 IN denotes in
T6148 5115-5123 VBZ denotes supports
T6149 5107-5111 IN denotes that
T6150 5112-5114 PRP denotes it
T6151 5124-5127 DT denotes the
T6152 5155-5160 NN denotes shape
T6153 5128-5135 JJ denotes typical
T6154 5136-5145 NN denotes biconcave
T6155 5146-5154 NN denotes membrane
T6156 5161-5164 CC denotes and
T6157 5165-5170 VBZ denotes leads
T6158 5171-5173 IN denotes to
T6159 5174-5175 DT denotes a
T6160 5198-5208 NN denotes resistance
T6161 5176-5181 JJR denotes lower
T6162 5182-5189 JJ denotes minimal
T6163 5190-5197 JJ denotes osmotic
T6164 5208-5209 . denotes .
T6165 5209-5349 sentence denotes Annexin A7 does not appear to have an influence on plasma membrane integrity itself as the maximal osmotic resistance value stays constant.
T6166 5210-5217 NN denotes Annexin
T6167 5218-5220 NN denotes A7
T6168 5230-5236 VB denotes appear
T6169 5221-5225 VBZ denotes does
T6170 5226-5229 RB denotes not
T6171 5237-5239 TO denotes to
T6172 5240-5244 VB denotes have
T6173 5245-5247 DT denotes an
T6174 5248-5257 NN denotes influence
T6175 5258-5260 IN denotes on
T6176 5261-5267 NN denotes plasma
T6177 5268-5276 NN denotes membrane
T6178 5277-5286 NN denotes integrity
T6179 5287-5293 PRP denotes itself
T6180 5294-5296 IN denotes as
T6181 5334-5339 VBZ denotes stays
T6182 5297-5300 DT denotes the
T6183 5328-5333 NN denotes value
T6184 5301-5308 JJ denotes maximal
T6185 5309-5316 JJ denotes osmotic
T6186 5317-5327 NN denotes resistance
T6187 5340-5348 JJ denotes constant
T6188 5348-5349 . denotes .
T6189 5349-5470 sentence denotes Ca2+ and membrane skeletal proteins are known to play key roles on the red blood cell membrane shape and stability [47].
T6190 5350-5354 NN denotes Ca2+
T6191 5377-5385 NN denotes proteins
T6192 5355-5358 CC denotes and
T6193 5359-5367 NN denotes membrane
T6194 5368-5376 JJ denotes skeletal
T6195 5390-5395 VBN denotes known
T6196 5386-5389 VBP denotes are
T6197 5396-5398 TO denotes to
T6198 5399-5403 VB denotes play
T6199 5404-5407 JJ denotes key
T6200 5408-5413 NNS denotes roles
T6201 5414-5416 IN denotes on
T6202 5417-5420 DT denotes the
T6203 5445-5450 NN denotes shape
T6204 5421-5424 JJ denotes red
T6205 5431-5435 NN denotes cell
T6206 5425-5430 NN denotes blood
T6207 5436-5444 NN denotes membrane
T6208 5451-5454 CC denotes and
T6209 5455-5464 NN denotes stability
T6210 5465-5466 -LRB- denotes [
T6211 5466-5468 CD denotes 47
T6212 5468-5469 -RRB- denotes ]
T6213 5469-5470 . denotes .
T6214 5470-5585 sentence denotes Annexins have been reported to bind directly to F-actin, we could however exclude such an activity for annexin A7.
T6215 5471-5479 NNS denotes Annexins
T6216 5490-5498 VBN denotes reported
T6217 5480-5484 VBP denotes have
T6218 5485-5489 VBN denotes been
T6219 5545-5552 VB denotes exclude
T6220 5499-5501 TO denotes to
T6221 5502-5506 VB denotes bind
T6222 5507-5515 RB denotes directly
T6223 5516-5518 IN denotes to
T6224 5519-5520 NN denotes F
T6225 5521-5526 NN denotes actin
T6226 5520-5521 HYPH denotes -
T6227 5526-5528 , denotes ,
T6228 5528-5530 PRP denotes we
T6229 5531-5536 MD denotes could
T6230 5537-5544 RB denotes however
T6231 5553-5557 JJ denotes such
T6232 5561-5569 NN denotes activity
T6233 5558-5560 DT denotes an
T6234 5570-5573 IN denotes for
T6235 5574-5581 NN denotes annexin
T6236 5582-5584 NN denotes A7
T6237 5584-5585 . denotes .
T6238 5585-5846 sentence denotes Nevertheless it might interact with other components and have a role in organizing the membrane cytoskeleton, controlling raft protein associations or influencing the ionic strength of red blood cells on its own or by interfering with other signaling pathways.
T6239 5586-5598 RB denotes Nevertheless
T6240 5608-5616 VB denotes interact
T6241 5599-5601 PRP denotes it
T6242 5602-5607 MD denotes might
T6243 5617-5621 IN denotes with
T6244 5622-5627 JJ denotes other
T6245 5628-5638 NNS denotes components
T6246 5639-5642 CC denotes and
T6247 5643-5647 VBP denotes have
T6248 5648-5649 DT denotes a
T6249 5650-5654 NN denotes role
T6250 5655-5657 IN denotes in
T6251 5658-5668 VBG denotes organizing
T6252 5669-5672 DT denotes the
T6253 5682-5694 NN denotes cytoskeleton
T6254 5673-5681 NN denotes membrane
T6255 5694-5696 , denotes ,
T6256 5696-5707 VBG denotes controlling
T6257 5708-5712 NN denotes raft
T6258 5713-5720 NN denotes protein
T6259 5721-5733 NNS denotes associations
T6260 5734-5736 CC denotes or
T6261 5737-5748 VBG denotes influencing
T6262 5749-5752 DT denotes the
T6263 5759-5767 NN denotes strength
T6264 5753-5758 JJ denotes ionic
T6265 5768-5770 IN denotes of
T6266 5771-5774 JJ denotes red
T6267 5781-5786 NNS denotes cells
T6268 5775-5780 NN denotes blood
T6269 5787-5789 IN denotes on
T6270 5790-5793 PRP$ denotes its
T6271 5794-5797 JJ denotes own
T6272 5798-5800 CC denotes or
T6273 5801-5803 IN denotes by
T6274 5804-5815 VBG denotes interfering
T6275 5816-5820 IN denotes with
T6276 5821-5826 JJ denotes other
T6277 5837-5845 NNS denotes pathways
T6278 5827-5836 NN denotes signaling
T6279 5845-5846 . denotes .
T6280 5846-5931 sentence denotes As discussed above annexin A7 could be involved in the cytoplasmic Ca2+ homeostasis.
T6281 5847-5849 IN denotes As
T6282 5850-5859 VBN denotes discussed
T6283 5886-5894 VBN denotes involved
T6284 5860-5865 RB denotes above
T6285 5866-5873 NN denotes annexin
T6286 5874-5876 NN denotes A7
T6287 5877-5882 MD denotes could
T6288 5883-5885 VB denotes be
T6289 5895-5897 IN denotes in
T6290 5898-5901 DT denotes the
T6291 5919-5930 NN denotes homeostasis
T6292 5902-5913 JJ denotes cytoplasmic
T6293 5914-5918 NN denotes Ca2+
T6294 5930-5931 . denotes .
T6295 5931-6123 sentence denotes It has been demonstrated that micromolar changes of the intracellular Ca2+ concentration exert a profound effect on the membrane properties that regulate red blood cell deformability [48,49].
T6296 5932-5934 PRP denotes It
T6297 5944-5956 VBN denotes demonstrated
T6298 5935-5938 VBZ denotes has
T6299 5939-5943 VBN denotes been
T6300 5957-5961 IN denotes that
T6301 6021-6026 VBP denotes exert
T6302 5962-5972 JJ denotes micromolar
T6303 5973-5980 NNS denotes changes
T6304 5981-5983 IN denotes of
T6305 5984-5987 DT denotes the
T6306 6007-6020 NN denotes concentration
T6307 5988-6001 JJ denotes intracellular
T6308 6002-6006 NN denotes Ca2+
T6309 6027-6028 DT denotes a
T6310 6038-6044 NN denotes effect
T6311 6029-6037 JJ denotes profound
T6312 6045-6047 IN denotes on
T6313 6048-6051 DT denotes the
T6314 6061-6071 NNS denotes properties
T6315 6052-6060 NN denotes membrane
T6316 6072-6076 WDT denotes that
T6317 6077-6085 VBP denotes regulate
T6318 6086-6089 JJ denotes red
T6319 6096-6100 NN denotes cell
T6320 6090-6095 NN denotes blood
T6321 6101-6114 NN denotes deformability
T6322 6115-6116 -LRB- denotes [
T6323 6119-6121 CD denotes 49
T6324 6116-6118 CD denotes 48
T6325 6118-6119 , denotes ,
T6326 6121-6122 -RRB- denotes ]
T6327 6122-6123 . denotes .
T6328 6123-6266 sentence denotes Furthermore, the intracellular Ca2+ was shown to regulate the membrane stability through modulation of cytoskeletal protein interactions [50].
T6329 6124-6135 RB denotes Furthermore
T6330 6164-6169 VBN denotes shown
T6331 6135-6137 , denotes ,
T6332 6137-6140 DT denotes the
T6333 6155-6159 NN denotes Ca2+
T6334 6141-6154 JJ denotes intracellular
T6335 6160-6163 VBD denotes was
T6336 6170-6172 TO denotes to
T6337 6173-6181 VB denotes regulate
T6338 6182-6185 DT denotes the
T6339 6195-6204 NN denotes stability
T6340 6186-6194 NN denotes membrane
T6341 6205-6212 IN denotes through
T6342 6213-6223 NN denotes modulation
T6343 6224-6226 IN denotes of
T6344 6227-6239 JJ denotes cytoskeletal
T6345 6240-6247 NN denotes protein
T6346 6248-6260 NNS denotes interactions
T6347 6261-6262 -LRB- denotes [
T6348 6262-6264 CD denotes 50
T6349 6264-6265 -RRB- denotes ]
T6350 6265-6266 . denotes .
T6351 6266-6376 sentence denotes Ca2+ also induces a transbilayer phospholipid redistribution inducing a shape change of red blood cells [51].
T6352 6267-6271 NN denotes Ca2+
T6353 6277-6284 VBZ denotes induces
T6354 6272-6276 RB denotes also
T6355 6285-6286 DT denotes a
T6356 6313-6327 NN denotes redistribution
T6357 6287-6299 NN denotes transbilayer
T6358 6300-6312 NN denotes phospholipid
T6359 6328-6336 VBG denotes inducing
T6360 6337-6338 DT denotes a
T6361 6345-6351 NN denotes change
T6362 6339-6344 NN denotes shape
T6363 6352-6354 IN denotes of
T6364 6355-6358 JJ denotes red
T6365 6365-6370 NNS denotes cells
T6366 6359-6364 NN denotes blood
T6367 6371-6372 -LRB- denotes [
T6368 6372-6374 CD denotes 51
T6369 6374-6375 -RRB- denotes ]
T6370 6375-6376 . denotes .
T6371 6376-6486 sentence denotes In addition, Ca2+ ions can drive spiculation of the membrane bilayer without involving the cytoskeleton [52].
T6372 6377-6379 IN denotes In
T6373 6404-6409 VB denotes drive
T6374 6380-6388 NN denotes addition
T6375 6388-6390 , denotes ,
T6376 6390-6394 NN denotes Ca2+
T6377 6395-6399 NNS denotes ions
T6378 6400-6403 MD denotes can
T6379 6410-6421 NN denotes spiculation
T6380 6422-6424 IN denotes of
T6381 6425-6428 DT denotes the
T6382 6438-6445 NN denotes bilayer
T6383 6429-6437 NN denotes membrane
T6384 6446-6453 IN denotes without
T6385 6454-6463 VBG denotes involving
T6386 6464-6467 DT denotes the
T6387 6468-6480 NN denotes cytoskeleton
T6388 6481-6482 -LRB- denotes [
T6389 6482-6484 CD denotes 52
T6390 6484-6485 -RRB- denotes ]
T6391 6485-6486 . denotes .
T6392 6486-6564 sentence denotes We have also observed a defect in platelet function in the annexin A7 mutant.
T6393 6487-6489 PRP denotes We
T6394 6500-6508 VBN denotes observed
T6395 6490-6494 VBP denotes have
T6396 6495-6499 RB denotes also
T6397 6509-6510 DT denotes a
T6398 6511-6517 NN denotes defect
T6399 6518-6520 IN denotes in
T6400 6521-6529 NN denotes platelet
T6401 6530-6538 NN denotes function
T6402 6539-6541 IN denotes in
T6403 6542-6545 DT denotes the
T6404 6557-6563 NN denotes mutant
T6405 6546-6553 NN denotes annexin
T6406 6554-6556 NN denotes A7
T6407 6563-6564 . denotes .
T6408 6564-6708 sentence denotes In the platelet aggregation experiments the initial aggregation velocity was slightly, but significantly lower in platelets lacking annexin A7.
T6409 6565-6567 IN denotes In
T6410 6638-6641 VBD denotes was
T6411 6568-6571 DT denotes the
T6412 6593-6604 NNS denotes experiments
T6413 6572-6580 NN denotes platelet
T6414 6581-6592 NN denotes aggregation
T6415 6605-6608 DT denotes the
T6416 6629-6637 NN denotes velocity
T6417 6609-6616 JJ denotes initial
T6418 6617-6628 NN denotes aggregation
T6419 6642-6650 RB denotes slightly
T6420 6670-6675 JJR denotes lower
T6421 6650-6652 , denotes ,
T6422 6652-6655 CC denotes but
T6423 6656-6669 RB denotes significantly
T6424 6676-6678 IN denotes in
T6425 6679-6688 NNS denotes platelets
T6426 6689-6696 VBG denotes lacking
T6427 6697-6704 NN denotes annexin
T6428 6705-6707 NN denotes A7
T6429 6707-6708 . denotes .
T6430 6708-6779 sentence denotes These data are not reflected by a change in the in vivo bleeding time.
T6431 6709-6714 DT denotes These
T6432 6715-6719 NNS denotes data
T6433 6728-6737 VBN denotes reflected
T6434 6720-6723 VBP denotes are
T6435 6724-6727 RB denotes not
T6436 6738-6740 IN denotes by
T6437 6741-6742 DT denotes a
T6438 6743-6749 NN denotes change
T6439 6750-6752 IN denotes in
T6440 6753-6756 DT denotes the
T6441 6774-6778 NN denotes time
T6442 6757-6759 FW denotes in
T6443 6760-6764 FW denotes vivo
T6444 6765-6773 NN denotes bleeding
T6445 6778-6779 . denotes .
T6446 6779-6950 sentence denotes However the reaction speed of murine platelets is much higher than those of human and due to the technical setup we might have missed larger changes in the mouse samples.
T6447 6780-6787 RB denotes However
T6448 6827-6829 VBZ denotes is
T6449 6788-6791 DT denotes the
T6450 6801-6806 NN denotes speed
T6451 6792-6800 NN denotes reaction
T6452 6807-6809 IN denotes of
T6453 6810-6816 JJ denotes murine
T6454 6817-6826 NNS denotes platelets
T6455 6830-6834 RB denotes much
T6456 6835-6841 JJR denotes higher
T6457 6842-6846 IN denotes than
T6458 6847-6852 DT denotes those
T6459 6853-6855 IN denotes of
T6460 6856-6861 JJ denotes human
T6461 6862-6865 CC denotes and
T6462 6866-6869 IN denotes due
T6463 6907-6913 VBN denotes missed
T6464 6870-6872 IN denotes to
T6465 6873-6876 DT denotes the
T6466 6887-6892 NN denotes setup
T6467 6877-6886 JJ denotes technical
T6468 6893-6895 PRP denotes we
T6469 6896-6901 MD denotes might
T6470 6902-6906 VB denotes have
T6471 6914-6920 JJR denotes larger
T6472 6921-6928 NNS denotes changes
T6473 6929-6931 IN denotes in
T6474 6932-6935 DT denotes the
T6475 6942-6949 NNS denotes samples
T6476 6936-6941 NN denotes mouse
T6477 6949-6950 . denotes .
T6478 6950-7108 sentence denotes The immediate reaction of mouse platelets and the absence of a lag phase after triggering may be caused by an immediately initiated thrombin generation [22].
T6479 6951-6954 DT denotes The
T6480 6965-6973 NN denotes reaction
T6481 6955-6964 JJ denotes immediate
T6482 7048-7054 VBN denotes caused
T6483 6974-6976 IN denotes of
T6484 6977-6982 NN denotes mouse
T6485 6983-6992 NNS denotes platelets
T6486 6993-6996 CC denotes and
T6487 6997-7000 DT denotes the
T6488 7001-7008 NN denotes absence
T6489 7009-7011 IN denotes of
T6490 7012-7013 DT denotes a
T6491 7018-7023 NN denotes phase
T6492 7014-7017 NN denotes lag
T6493 7024-7029 IN denotes after
T6494 7030-7040 NN denotes triggering
T6495 7041-7044 MD denotes may
T6496 7045-7047 VB denotes be
T6497 7055-7057 IN denotes by
T6498 7058-7060 DT denotes an
T6499 7092-7102 NN denotes generation
T6500 7061-7072 RB denotes immediately
T6501 7073-7082 VBN denotes initiated
T6502 7083-7091 NN denotes thrombin
T6503 7103-7104 -LRB- denotes [
T6504 7104-7106 CD denotes 22
T6505 7106-7107 -RRB- denotes ]
T6506 7107-7108 . denotes .
T6507 7108-7295 sentence denotes As known from the frequent human vWF-syndrome or other haemostatic diseases, small defects often are clinically silent and do not result in physiological changes under normal conditions.
T6508 7109-7111 IN denotes As
T6509 7112-7117 VBN denotes known
T6510 7206-7209 VBP denotes are
T6511 7118-7122 IN denotes from
T6512 7123-7126 DT denotes the
T6513 7146-7154 NN denotes syndrome
T6514 7127-7135 JJ denotes frequent
T6515 7136-7141 JJ denotes human
T6516 7142-7145 NN denotes vWF
T6517 7145-7146 HYPH denotes -
T6518 7155-7157 CC denotes or
T6519 7158-7163 JJ denotes other
T6520 7176-7184 NNS denotes diseases
T6521 7164-7175 JJ denotes haemostatic
T6522 7184-7186 , denotes ,
T6523 7186-7191 JJ denotes small
T6524 7192-7199 NNS denotes defects
T6525 7200-7205 RB denotes often
T6526 7210-7220 RB denotes clinically
T6527 7221-7227 JJ denotes silent
T6528 7228-7231 CC denotes and
T6529 7232-7234 VBP denotes do
T6530 7239-7245 VB denotes result
T6531 7235-7238 RB denotes not
T6532 7246-7248 IN denotes in
T6533 7249-7262 JJ denotes physiological
T6534 7263-7270 NNS denotes changes
T6535 7271-7276 IN denotes under
T6536 7277-7283 JJ denotes normal
T6537 7284-7294 NNS denotes conditions
T6538 7294-7295 . denotes .
T6539 7295-7490 sentence denotes Only in situations with severe physical injury, distinct environmental influences or additional platelet attributes like the platelet antigen polymorphism [53] differences might become apparent.
T6540 7296-7300 RB denotes Only
T6541 7301-7303 IN denotes in
T6542 7474-7480 VB denotes become
T6543 7304-7314 NNS denotes situations
T6544 7315-7319 IN denotes with
T6545 7320-7326 JJ denotes severe
T6546 7336-7342 NN denotes injury
T6547 7327-7335 JJ denotes physical
T6548 7342-7344 , denotes ,
T6549 7344-7352 JJ denotes distinct
T6550 7367-7377 NNS denotes influences
T6551 7353-7366 JJ denotes environmental
T6552 7378-7380 CC denotes or
T6553 7381-7391 JJ denotes additional
T6554 7392-7400 NN denotes platelet
T6555 7401-7411 VBZ denotes attributes
T6556 7412-7416 IN denotes like
T6557 7417-7420 DT denotes the
T6558 7456-7467 NNS denotes differences
T6559 7421-7429 NN denotes platelet
T6560 7430-7437 NN denotes antigen
T6561 7438-7450 NN denotes polymorphism
T6562 7451-7452 -LRB- denotes [
T6563 7452-7454 CD denotes 53
T6564 7454-7455 -RRB- denotes ]
T6565 7468-7473 MD denotes might
T6566 7481-7489 JJ denotes apparent
T6567 7489-7490 . denotes .
R2766 T5213 T5214 compound Annexin,A7
R2767 T5214 T5215 nsubjpass A7,thought
R2768 T5216 T5215 auxpass is,thought
R2769 T5217 T5218 aux to,have
R2770 T5218 T5215 xcomp have,thought
R2771 T5219 T5220 det a,role
R2772 T5220 T5218 dobj role,have
R2773 T5221 T5218 prep in,have
R2774 T5222 T5223 compound vesicle,fusion
R2775 T5223 T5221 pobj fusion,in
R2776 T5224 T5221 cc and,in
R2777 T5225 T5221 conj in,in
R2778 T5226 T5225 pcomp regulating,in
R2779 T5227 T5226 cc and,regulating
R2780 T5228 T5226 conj stabilizing,regulating
R2781 T5229 T5230 compound membrane,domains
R2782 T5230 T5228 dobj domains,stabilizing
R2783 T5231 T5232 punct [,1
R2784 T5232 T5215 parataxis 1,thought
R2785 T5233 T5232 punct ],1
R2786 T5234 T5215 punct .,thought
R2787 T5236 T5237 det The,protein
R2788 T5237 T5238 nsubjpass protein,localized
R2789 T5238 T5241 ccomp localized,is
R2790 T5239 T5238 aux has,localized
R2791 T5240 T5238 auxpass been,localized
R2792 T5242 T5238 prep to,localized
R2793 T5243 T5244 det the,membrane
R2794 T5244 T5242 pobj membrane,to
R2795 T5245 T5244 compound plasma,membrane
R2796 T5246 T5244 prep including,membrane
R2797 T5247 T5248 compound raft,subdomains
R2798 T5248 T5246 pobj subdomains,including
R2799 T5249 T5241 punct ", ",is
R2800 T5250 T5241 advmod furthermore,is
R2801 T5251 T5241 nsubj it,is
R2802 T5252 T5241 acomp present,is
R2803 T5253 T5241 prep in,is
R2804 T5254 T5255 det the,cytosol
R2805 T5255 T5253 pobj cytosol,in
R2806 T5256 T5257 advmod where,found
R2807 T5257 T5255 relcl found,cytosol
R2808 T5258 T5257 nsubjpass it,found
R2809 T5259 T5257 auxpass is,found
R2810 T5260 T5257 prep on,found
R2811 T5261 T5262 amod subcellular,structures
R2812 T5262 T5260 pobj structures,on
R2813 T5263 T5264 npadvmod vesicle,like
R2814 T5264 T5262 amod like,structures
R2815 T5265 T5264 punct -,like
R2816 T5266 T5241 punct .,is
R2817 T5268 T5269 det This,distribution
R2818 T5269 T5270 nsubj distribution,appears
R2819 T5271 T5272 aux to,be
R2820 T5272 T5270 xcomp be,appears
R2821 T5273 T5272 acomp independent,be
R2822 T5274 T5273 prep of,independent
R2823 T5275 T5276 det the,type
R2824 T5276 T5274 pobj type,of
R2825 T5277 T5276 nmod tissue,type
R2826 T5278 T5277 cc or,tissue
R2827 T5279 T5277 conj cell,tissue
R2828 T5280 T5276 acl analysed,type
R2829 T5281 T5270 punct .,appears
R2830 T5283 T5284 prep In,increase
R2831 T5285 T5286 amod specialized,cells
R2832 T5286 T5283 pobj cells,In
R2833 T5287 T5285 cc or,specialized
R2834 T5288 T5289 advmod terminally,differentiated
R2835 T5289 T5285 conj differentiated,specialized
R2836 T5290 T5284 punct ", ",increase
R2837 T5291 T5292 compound expression,levels
R2838 T5292 T5284 nsubj levels,increase
R2839 T5293 T5284 cc and,increase
R2840 T5294 T5295 advmod frequently,expressed
R2841 T5295 T5284 conj expressed,increase
R2842 T5296 T5297 det the,larger
R2843 T5297 T5295 nsubjpass larger,expressed
R2844 T5298 T5297 prep of,larger
R2845 T5299 T5300 det the,isoforms
R2846 T5300 T5298 pobj isoforms,of
R2847 T5301 T5300 nummod two,isoforms
R2848 T5302 T5295 aux is,expressed
R2849 T5303 T5295 auxpass being,expressed
R2850 T5304 T5305 punct [,35
R2851 T5305 T5295 parataxis 35,expressed
R2852 T5306 T5305 nummod 6,35
R2853 T5307 T5305 punct ",",35
R2854 T5308 T5305 nummod 34,35
R2855 T5309 T5305 punct ",",35
R2856 T5310 T5305 punct ],35
R2857 T5311 T5284 punct .,increase
R2858 T5313 T5314 amod Red,cells
R2859 T5314 T5316 nsubjpass cells,shown
R2860 T5315 T5314 compound blood,cells
R2861 T5317 T5314 punct ", ",cells
R2862 T5318 T5319 dep which,thought
R2863 T5319 T5314 relcl thought,cells
R2864 T5320 T5319 auxpass were,thought
R2865 T5321 T5322 aux to,be
R2866 T5322 T5319 xcomp be,thought
R2867 T5323 T5322 acomp devoid,be
R2868 T5324 T5323 prep of,devoid
R2869 T5325 T5326 compound annexin,A7
R2870 T5326 T5324 pobj A7,of
R2871 T5327 T5316 punct ", ",shown
R2872 T5328 T5316 auxpass were,shown
R2873 T5329 T5316 advmod recently,shown
R2874 T5330 T5331 aux to,harbor
R2875 T5331 T5316 xcomp harbor,shown
R2876 T5332 T5333 det the,isoform
R2877 T5333 T5331 dobj isoform,harbor
R2878 T5334 T5335 nummod 47,kDa
R2879 T5335 T5333 compound kDa,isoform
R2880 T5336 T5337 advmod together,with
R2881 T5337 T5333 prep with,isoform
R2882 T5338 T5339 poss its,partner
R2883 T5339 T5337 pobj partner,with
R2884 T5340 T5339 amod binding,partner
R2885 T5341 T5339 appos sorcin,partner
R2886 T5342 T5343 punct [,7
R2887 T5343 T5316 parataxis 7,shown
R2888 T5344 T5343 punct ],7
R2889 T5345 T5316 punct .,shown
R2890 T5347 T5348 nsubj We,showed
R2891 T5349 T5350 det the,presence
R2892 T5350 T5348 dobj presence,showed
R2893 T5351 T5350 prep of,presence
R2894 T5352 T5353 det the,isoform
R2895 T5353 T5351 pobj isoform,of
R2896 T5354 T5355 nummod 51,kDa
R2897 T5355 T5353 compound kDa,isoform
R2898 T5356 T5357 advmod as,well
R2899 T5357 T5348 advmod well,showed
R2900 T5358 T5348 punct ", ",showed
R2901 T5359 T5348 advcl adding,showed
R2902 T5360 T5361 amod red,cells
R2903 T5361 T5359 dobj cells,adding
R2904 T5362 T5361 compound blood,cells
R2905 T5363 T5359 prep to,adding
R2906 T5364 T5365 det the,list
R2907 T5365 T5363 pobj list,to
R2908 T5366 T5365 prep of,list
R2909 T5367 T5366 pobj cells,of
R2910 T5368 T5369 dep that,harbor
R2911 T5369 T5367 relcl harbor,cells
R2912 T5370 T5371 det this,isoform
R2913 T5371 T5369 dobj isoform,harbor
R2914 T5372 T5348 punct .,showed
R2915 T5374 T5375 ccomp Salzer,showed
R2916 T5376 T5377 advmod et,al.
R2917 T5377 T5374 advmod al.,Salzer
R2918 T5378 T5379 punct [,7
R2919 T5379 T5374 parataxis 7,Salzer
R2920 T5380 T5379 punct ],7
R2921 T5381 T5374 preconj not,Salzer
R2922 T5382 T5381 advmod only,not
R2923 T5383 T5374 conj demonstrated,Salzer
R2924 T5384 T5385 det the,presence
R2925 T5385 T5383 dobj presence,demonstrated
R2926 T5386 T5385 prep of,presence
R2927 T5387 T5388 compound annexin,A7
R2928 T5388 T5386 pobj A7,of
R2929 T5389 T5383 prep in,demonstrated
R2930 T5390 T5391 amod red,cells
R2931 T5391 T5389 pobj cells,in
R2932 T5392 T5391 compound blood,cells
R2933 T5393 T5375 punct ", ",showed
R2934 T5394 T5375 nsubj they,showed
R2935 T5395 T5375 advmod also,showed
R2936 T5396 T5397 mark that,were
R2937 T5397 T5375 ccomp were,showed
R2938 T5398 T5399 compound annexin,A7
R2939 T5399 T5397 nsubj A7,were
R2940 T5400 T5399 cc and,A7
R2941 T5401 T5399 conj sorcin,A7
R2942 T5402 T5397 acomp enriched,were
R2943 T5403 T5397 prep in,were
R2944 T5404 T5405 compound membrane,raft
R2945 T5405 T5406 compound raft,domains
R2946 T5406 T5403 pobj domains,in
R2947 T5407 T5406 prep of,domains
R2948 T5408 T5407 pobj nanovesicles,of
R2949 T5409 T5408 acl formed,nanovesicles
R2950 T5410 T5409 prep from,formed
R2951 T5411 T5412 amod red,cells
R2952 T5412 T5410 pobj cells,from
R2953 T5413 T5412 compound blood,cells
R2954 T5414 T5415 advmod in,vitro
R2955 T5415 T5409 advmod vitro,formed
R2956 T5416 T5375 punct .,showed
R2957 T5418 T5419 compound Raft,domains
R2958 T5419 T5420 nsubjpass domains,considered
R2959 T5421 T5420 prep in,considered
R2960 T5422 T5421 amod general,in
R2961 T5423 T5420 auxpass are,considered
R2962 T5424 T5425 amod key,players
R2963 T5425 T5420 oprd players,considered
R2964 T5426 T5425 prep in,players
R2965 T5427 T5428 compound membrane,organization
R2966 T5428 T5426 pobj organization,in
R2967 T5429 T5426 cc and,in
R2968 T5430 T5426 conj in,in
R2969 T5431 T5430 pcomp mediating,in
R2970 T5432 T5433 det the,process
R2971 T5433 T5431 dobj process,mediating
R2972 T5434 T5433 compound vesiculation,process
R2973 T5435 T5420 punct .,considered
R2974 T5437 T5438 nsubj They,result
R2975 T5439 T5438 prep from,result
R2976 T5440 T5441 det the,clustering
R2977 T5441 T5439 pobj clustering,from
R2978 T5442 T5441 prep of,clustering
R2979 T5443 T5442 pobj sphingolipids,of
R2980 T5444 T5443 cc and,sphingolipids
R2981 T5445 T5443 conj cholesterol,sphingolipids
R2982 T5446 T5441 prep in,clustering
R2983 T5447 T5448 det the,leaflet
R2984 T5448 T5446 pobj leaflet,in
R2985 T5449 T5448 amod outer,leaflet
R2986 T5450 T5448 prep of,leaflet
R2987 T5451 T5452 det the,membrane
R2988 T5452 T5450 pobj membrane,of
R2989 T5453 T5452 acl connected,membrane
R2990 T5454 T5453 prep to,connected
R2991 T5455 T5454 pobj phospholipids,to
R2992 T5456 T5455 cc and,phospholipids
R2993 T5457 T5455 conj cholesterol,phospholipids
R2994 T5458 T5453 prep in,connected
R2995 T5459 T5460 det the,leaflet
R2996 T5460 T5458 pobj leaflet,in
R2997 T5461 T5460 amod inner,leaflet
R2998 T5462 T5438 cc and,result
R2999 T5463 T5438 conj are,result
R3000 T5464 T5463 acomp enriched,are
R3001 T5465 T5463 prep in,are
R3002 T5466 T5467 amod special,proteins
R3003 T5467 T5465 pobj proteins,in
R3004 T5468 T5438 punct .,result
R3005 T5470 T5471 advmod Biochemically,defined
R3006 T5472 T5471 nsubjpass rafts,defined
R3007 T5473 T5471 auxpass are,defined
R3008 T5474 T5471 prep as,defined
R3009 T5475 T5474 pobj membranes,as
R3010 T5476 T5477 dep that,are
R3011 T5477 T5475 relcl are,membranes
R3012 T5478 T5477 acomp resistant,are
R3013 T5479 T5478 prep to,resistant
R3014 T5480 T5479 pobj extraction,to
R3015 T5481 T5480 prep by,extraction
R3016 T5482 T5483 amod cold,X
R3017 T5483 T5481 pobj X,by
R3018 T5484 T5483 compound Triton,X
R3019 T5485 T5483 punct -,X
R3020 T5486 T5483 nummod 100,X
R3021 T5487 T5471 cc and,defined
R3022 T5488 T5489 aux can,floated
R3023 T5489 T5471 conj floated,defined
R3024 T5490 T5489 auxpass be,floated
R3025 T5491 T5489 prep to,floated
R3026 T5492 T5493 amod low,densities
R3027 T5493 T5491 pobj densities,to
R3028 T5494 T5489 prep in,floated
R3029 T5495 T5496 compound sucrose,gradient
R3030 T5496 T5497 compound gradient,centrifugation
R3031 T5497 T5494 pobj centrifugation,in
R3032 T5498 T5499 punct [,36
R3033 T5499 T5489 parataxis 36,floated
R3034 T5500 T5499 punct ],36
R3035 T5501 T5471 punct .,defined
R3036 T5503 T5504 det The,findings
R3037 T5504 T5505 nsubj findings,suggested
R3038 T5506 T5504 prep of,findings
R3039 T5507 T5506 pobj Caohuy,of
R3040 T5508 T5509 advmod et,al.
R3041 T5509 T5507 advmod al.,Caohuy
R3042 T5510 T5511 punct [,37
R3043 T5511 T5507 parataxis 37,Caohuy
R3044 T5512 T5511 punct ],37
R3045 T5513 T5514 mark that,mediates
R3046 T5514 T5504 acl mediates,findings
R3047 T5515 T5516 compound annexin,A7
R3048 T5516 T5514 nsubj A7,mediates
R3049 T5517 T5518 compound membrane,aggregation
R3050 T5518 T5514 dobj aggregation,mediates
R3051 T5519 T5505 advmod also,suggested
R3052 T5520 T5521 mark that,is
R3053 T5521 T5505 ccomp is,suggested
R3054 T5522 T5523 compound annexin,A7
R3055 T5523 T5521 nsubj A7,is
R3056 T5524 T5525 det an,component
R3057 T5525 T5521 attr component,is
R3058 T5526 T5525 amod essential,component
R3059 T5527 T5521 prep during,is
R3060 T5528 T5527 pobj vesiculation,during
R3061 T5529 T5505 punct .,suggested
R3062 T5531 T5532 prep In,reported
R3063 T5533 T5531 pobj addition,In
R3064 T5534 T5532 nsubj they,reported
R3065 T5535 T5536 det a,activation
R3066 T5536 T5532 dobj activation,reported
R3067 T5537 T5536 amod further,activation
R3068 T5538 T5536 prep of,activation
R3069 T5539 T5540 det the,process
R3070 T5540 T5538 pobj process,of
R3071 T5541 T5540 compound vesiculation,process
R3072 T5542 T5536 prep by,activation
R3073 T5543 T5542 pobj GTP,by
R3074 T5544 T5532 cc and,reported
R3075 T5545 T5532 conj proposed,reported
R3076 T5546 T5547 mark that,acts
R3077 T5547 T5545 ccomp acts,proposed
R3078 T5548 T5549 compound annexin,A7
R3079 T5549 T5547 nsubj A7,acts
R3080 T5550 T5547 prep as,acts
R3081 T5551 T5552 det a,GTPase
R3082 T5552 T5550 pobj GTPase,as
R3083 T5553 T5532 punct .,reported
R3084 T5555 T5556 advmod Similarly,enhanced
R3085 T5557 T5556 punct ", ",enhanced
R3086 T5558 T5559 det the,presence
R3087 T5559 T5556 nsubj presence,enhanced
R3088 T5560 T5559 prep of,presence
R3089 T5561 T5560 pobj GTP,of
R3090 T5562 T5563 det the,secretion
R3091 T5563 T5556 dobj secretion,enhanced
R3092 T5564 T5563 prep of,secretion
R3093 T5565 T5564 pobj surfactant,of
R3094 T5566 T5563 prep by,secretion
R3095 T5567 T5568 compound annexin,A7
R3096 T5568 T5566 pobj A7,by
R3097 T5569 T5556 punct .,enhanced
R3098 T5571 T5572 det These,results
R3099 T5572 T5573 nsubjpass results,thought
R3100 T5574 T5573 auxpass were,thought
R3101 T5575 T5576 aux to,support
R3102 T5576 T5573 xcomp support,thought
R3103 T5577 T5578 det a,role
R3104 T5578 T5576 dobj role,support
R3105 T5579 T5578 amod direct,role
R3106 T5580 T5578 prep for,role
R3107 T5581 T5582 compound annexin,A7
R3108 T5582 T5580 pobj A7,for
R3109 T5583 T5578 prep in,role
R3110 T5584 T5585 amod surfactant,secretion
R3111 T5585 T5583 pobj secretion,in
R3112 T5586 T5573 punct ", ",thought
R3113 T5587 T5573 cc but,thought
R3114 T5588 T5589 prep in,separated
R3115 T5589 T5573 conj separated,thought
R3116 T5590 T5591 det these,studies
R3117 T5591 T5588 pobj studies,in
R3118 T5592 T5593 compound annexin,A7
R3119 T5593 T5594 npadvmod A7,mediated
R3120 T5594 T5595 amod mediated,fusion
R3121 T5595 T5589 nsubjpass fusion,separated
R3122 T5596 T5595 compound membrane,fusion
R3123 T5597 T5589 auxpass was,separated
R3124 T5598 T5589 prep from,separated
R3125 T5599 T5600 det a,mechanism
R3126 T5600 T5598 pobj mechanism,from
R3127 T5601 T5600 amod second,mechanism
R3128 T5602 T5603 npadvmod GTP,dependent
R3129 T5603 T5600 amod dependent,mechanism
R3130 T5604 T5603 punct -,dependent
R3131 T5605 T5606 punct [,38
R3132 T5606 T5589 parataxis 38,separated
R3133 T5607 T5606 punct ],38
R3134 T5608 T5589 punct .,separated
R3135 T5610 T5611 advcl Having,tested
R3136 T5612 T5613 det an,mouse
R3137 T5613 T5610 dobj mouse,Having
R3138 T5614 T5615 compound annexin,A7
R3139 T5615 T5613 compound A7,mouse
R3140 T5616 T5613 compound knockout,mouse
R3141 T5617 T5611 nsubj we,tested
R3142 T5618 T5619 det the,involvement
R3143 T5619 T5611 dobj involvement,tested
R3144 T5620 T5619 prep of,involvement
R3145 T5621 T5622 compound annexin,A7
R3146 T5622 T5620 pobj A7,of
R3147 T5623 T5619 prep in,involvement
R3148 T5624 T5623 pobj budding,in
R3149 T5625 T5624 prep of,budding
R3150 T5626 T5627 amod red,cell
R3151 T5627 T5629 compound cell,vesicles
R3152 T5628 T5627 compound blood,cell
R3153 T5629 T5625 pobj vesicles,of
R3154 T5630 T5611 punct .,tested
R3155 T5632 T5633 poss Our,data
R3156 T5633 T5634 nsubj data,suggest
R3157 T5635 T5636 mark that,is
R3158 T5636 T5634 ccomp is,suggest
R3159 T5637 T5638 det the,efficiency
R3160 T5638 T5636 nsubj efficiency,is
R3161 T5639 T5638 prep of,efficiency
R3162 T5640 T5641 nmod micro,nanovesicle
R3163 T5641 T5644 compound nanovesicle,formation
R3164 T5642 T5641 punct -,nanovesicle
R3165 T5643 T5641 cc and,nanovesicle
R3166 T5644 T5639 pobj formation,of
R3167 T5645 T5636 neg not,is
R3168 T5646 T5647 advmod significantly,different
R3169 T5647 T5636 acomp different,is
R3170 T5648 T5636 prep in,is
R3171 T5649 T5650 amod wild,type
R3172 T5650 T5651 nmod type,cells
R3173 T5651 T5648 pobj cells,in
R3174 T5652 T5650 cc and,type
R3175 T5653 T5650 conj mutant,type
R3176 T5654 T5651 amod red,cells
R3177 T5655 T5651 compound blood,cells
R3178 T5656 T5634 punct .,suggest
R3179 T5658 T5659 advmod Likewise,were
R3180 T5660 T5659 punct ", ",were
R3181 T5661 T5662 compound Dictyostelium,discoideum
R3182 T5662 T5663 compound discoideum,cells
R3183 T5663 T5659 nsubj cells,were
R3184 T5664 T5663 punct ", ",cells
R3185 T5665 T5666 prep in,was
R3186 T5666 T5663 relcl was,cells
R3187 T5667 T5665 pobj which,in
R3188 T5668 T5669 det the,gene
R3189 T5669 T5666 nsubj gene,was
R3190 T5670 T5669 amod single,gene
R3191 T5671 T5669 compound annexin,gene
R3192 T5672 T5666 acomp inactivated,was
R3193 T5673 T5659 punct ", ",were
R3194 T5674 T5659 neg not,were
R3195 T5675 T5659 acomp impaired,were
R3196 T5676 T5675 prep in,impaired
R3197 T5677 T5676 pobj processes,in
R3198 T5678 T5677 acl requiring,processes
R3199 T5679 T5680 compound membrane,fusion
R3200 T5680 T5678 dobj fusion,requiring
R3201 T5681 T5682 punct [,39
R3202 T5682 T5659 parataxis 39,were
R3203 T5683 T5682 punct [,39
R3204 T5684 T5682 punct ],39
R3205 T5685 T5682 punct ;,39
R3206 T5686 T5682 cc and,39
R3207 T5687 T5682 conj data,39
R3208 T5688 T5687 amod unpublished,data
R3209 T5689 T5687 punct ],data
R3210 T5690 T5659 punct .,were
R3211 T5692 T5693 nsubj It,be
R3212 T5694 T5693 aux might,be
R3213 T5695 T5693 advmod well,be
R3214 T5696 T5697 mark that,turn
R3215 T5697 T5693 ccomp turn,be
R3216 T5698 T5699 det the,fusion
R3217 T5699 T5697 nsubj fusion,turn
R3218 T5700 T5699 amod observed,fusion
R3219 T5701 T5699 prep of,fusion
R3220 T5702 T5703 compound phospholipid,layers
R3221 T5703 T5701 pobj layers,of
R3222 T5704 T5699 prep by,fusion
R3223 T5705 T5706 compound annexin,A7
R3224 T5706 T5704 pobj A7,by
R3225 T5707 T5699 prep in,fusion
R3226 T5708 T5709 det the,presence
R3227 T5709 T5707 pobj presence,in
R3228 T5710 T5709 prep of,presence
R3229 T5711 T5712 amod high,concentrations
R3230 T5712 T5710 pobj concentrations,of
R3231 T5713 T5712 compound Ca2+,concentrations
R3232 T5714 T5697 aux may,turn
R3233 T5715 T5697 prt out,turn
R3234 T5716 T5717 aux to,be
R3235 T5717 T5697 xcomp be,turn
R3236 T5718 T5719 det an,effect
R3237 T5719 T5717 attr effect,be
R3238 T5720 T5721 advmod in,vitro
R3239 T5721 T5719 amod vitro,effect
R3240 T5722 T5693 punct .,be
R3241 T5724 T5725 advmod Similarly,be
R3242 T5726 T5725 punct ", ",be
R3243 T5727 T5728 det the,abundance
R3244 T5728 T5725 nsubj abundance,be
R3245 T5729 T5728 amod high,abundance
R3246 T5730 T5728 prep of,abundance
R3247 T5731 T5732 compound annexin,A7
R3248 T5732 T5730 pobj A7,of
R3249 T5733 T5728 prep in,abundance
R3250 T5734 T5735 nmod micro,nanovesicles
R3251 T5735 T5733 pobj nanovesicles,in
R3252 T5736 T5735 punct -,nanovesicles
R3253 T5737 T5735 cc and,nanovesicles
R3254 T5738 T5725 aux might,be
R3255 T5739 T5725 acomp fortuitous,be
R3256 T5740 T5741 mark as,appears
R3257 T5741 T5725 advcl appears,be
R3258 T5742 T5743 det a,percentage
R3259 T5743 T5741 nsubj percentage,appears
R3260 T5744 T5743 amod significant,percentage
R3261 T5745 T5743 prep of,percentage
R3262 T5746 T5747 det the,membrane
R3263 T5747 T5745 pobj membrane,of
R3264 T5748 T5749 amod red,cell
R3265 T5749 T5747 compound cell,membrane
R3266 T5750 T5749 compound blood,cell
R3267 T5751 T5747 punct ", ",membrane
R3268 T5752 T5753 prep with,associates
R3269 T5753 T5747 relcl associates,membrane
R3270 T5754 T5752 pobj which,with
R3271 T5755 T5756 compound annexin,A7
R3272 T5756 T5753 nsubj A7,associates
R3273 T5757 T5758 advmod when,rise
R3274 T5758 T5753 advcl rise,associates
R3275 T5759 T5760 det the,levels
R3276 T5760 T5758 nsubj levels,rise
R3277 T5761 T5760 compound Ca2+,levels
R3278 T5762 T5741 punct ", ",appears
R3279 T5763 T5764 aux to,involved
R3280 T5764 T5741 xcomp involved,appears
R3281 T5765 T5764 auxpass be,involved
R3282 T5766 T5764 prep in,involved
R3283 T5767 T5768 det the,formation
R3284 T5768 T5766 pobj formation,in
R3285 T5769 T5768 prep of,formation
R3286 T5770 T5769 pobj exovesicles,of
R3287 T5771 T5725 punct .,be
R3288 T5773 T5774 advmod Furthermore,indicates
R3289 T5775 T5774 punct ", ",indicates
R3290 T5776 T5777 det the,distribution
R3291 T5777 T5774 nsubj distribution,indicates
R3292 T5778 T5777 prep of,distribution
R3293 T5779 T5780 det both,isoforms
R3294 T5780 T5778 pobj isoforms,of
R3295 T5781 T5782 compound annexin,A7
R3296 T5782 T5780 compound A7,isoforms
R3297 T5783 T5777 prep in,distribution
R3298 T5784 T5783 pobj gradients,in
R3299 T5785 T5784 prep of,gradients
R3300 T5786 T5787 amod red,cells
R3301 T5787 T5785 pobj cells,of
R3302 T5788 T5787 compound blood,cells
R3303 T5789 T5790 det a,function
R3304 T5790 T5774 dobj function,indicates
R3305 T5791 T5792 dep which,differs
R3306 T5792 T5790 relcl differs,function
R3307 T5793 T5792 prep from,differs
R3308 T5794 T5793 pcomp organizing,from
R3309 T5795 T5796 amod subcellular,membranes
R3310 T5796 T5794 dobj membranes,organizing
R3311 T5797 T5796 cc or,membranes
R3312 T5798 T5799 compound membrane,pathways
R3313 T5799 T5796 conj pathways,membranes
R3314 T5800 T5774 punct .,indicates
R3315 T5802 T5803 mark Whereas,associated
R3316 T5803 T5808 advcl associated,distributes
R3317 T5804 T5805 compound annexin,A2
R3318 T5805 T5803 nsubjpass A2,associated
R3319 T5806 T5803 auxpass is,associated
R3320 T5807 T5803 advmod tightly,associated
R3321 T5809 T5803 prep with,associated
R3322 T5810 T5809 pobj endosomes,with
R3323 T5811 T5803 cc and,associated
R3324 T5812 T5813 aux may,have
R3325 T5813 T5803 conj have,associated
R3326 T5814 T5813 dobj functions,have
R3327 T5815 T5813 prep in,have
R3328 T5816 T5817 compound membrane,fusion
R3329 T5817 T5815 pobj fusion,in
R3330 T5818 T5817 cc and,fusion
R3331 T5819 T5820 det the,pathway
R3332 T5820 T5817 conj pathway,fusion
R3333 T5821 T5820 amod endosomal,pathway
R3334 T5822 T5808 punct ", ",distributes
R3335 T5823 T5824 compound annexin,A7
R3336 T5824 T5808 nsubj A7,distributes
R3337 T5825 T5808 prep with,distributes
R3338 T5826 T5827 compound plasma,membrane
R3339 T5827 T5828 compound membrane,domains
R3340 T5828 T5825 pobj domains,with
R3341 T5829 T5828 compound raft,domains
R3342 T5830 T5828 prep of,domains
R3343 T5831 T5832 amod different,types
R3344 T5832 T5830 pobj types,of
R3345 T5833 T5832 cc and,types
R3346 T5834 T5832 conj densities,types
R3347 T5835 T5808 punct .,distributes
R3348 T5837 T5838 advmod Interestingly,lowered
R3349 T5839 T5838 punct ", ",lowered
R3350 T5840 T5838 prep in,lowered
R3351 T5841 T5840 pobj vesicles,in
R3352 T5842 T5841 prep of,vesicles
R3353 T5843 T5844 amod red,cells
R3354 T5844 T5842 pobj cells,of
R3355 T5845 T5844 compound blood,cells
R3356 T5846 T5844 acl lacking,cells
R3357 T5847 T5848 compound annexin,A7
R3358 T5848 T5846 dobj A7,lacking
R3359 T5849 T5850 det the,amount
R3360 T5850 T5838 nsubjpass amount,lowered
R3361 T5851 T5850 prep of,amount
R3362 T5852 T5851 pobj sorcin,of
R3363 T5853 T5838 auxpass is,lowered
R3364 T5854 T5838 punct ", ",lowered
R3365 T5855 T5838 advcl indicating,lowered
R3366 T5856 T5857 mark that,affected
R3367 T5857 T5855 ccomp affected,indicating
R3368 T5858 T5859 poss its,localisation
R3369 T5859 T5857 nsubjpass localisation,affected
R3370 T5860 T5857 auxpass is,affected
R3371 T5861 T5857 agent by,affected
R3372 T5862 T5863 det the,loss
R3373 T5863 T5861 pobj loss,by
R3374 T5864 T5863 prep of,loss
R3375 T5865 T5866 compound annexin,A7
R3376 T5866 T5864 pobj A7,of
R3377 T5867 T5857 cc or,affected
R3378 T5868 T5869 poss its,expression
R3379 T5869 T5870 nsubjpass expression,reduced
R3380 T5870 T5857 conj reduced,affected
R3381 T5871 T5869 prep during,expression
R3382 T5872 T5873 amod red,cell
R3383 T5873 T5875 compound cell,development
R3384 T5874 T5873 compound blood,cell
R3385 T5875 T5871 pobj development,during
R3386 T5876 T5870 auxpass was,reduced
R3387 T5877 T5838 punct .,lowered
R3388 T5879 T5880 aux Having,excluded
R3389 T5880 T5881 advcl excluded,act
R3390 T5882 T5883 det a,role
R3391 T5883 T5880 dobj role,excluded
R3392 T5884 T5883 amod direct,role
R3393 T5885 T5883 prep in,role
R3394 T5886 T5887 compound vesicle,formation
R3395 T5887 T5885 pobj formation,in
R3396 T5888 T5887 cc and,formation
R3397 T5889 T5890 compound membrane,fusion
R3398 T5890 T5887 conj fusion,formation
R3399 T5891 T5881 punct ", ",act
R3400 T5892 T5893 compound annexin,A7
R3401 T5893 T5881 nsubj A7,act
R3402 T5894 T5881 aux might,act
R3403 T5895 T5881 prep by,act
R3404 T5896 T5897 poss its,property
R3405 T5897 T5895 pobj property,by
R3406 T5898 T5897 prep as,property
R3407 T5899 T5900 npadvmod Ca2+,binding
R3408 T5900 T5902 amod binding,protein
R3409 T5901 T5900 punct -,binding
R3410 T5902 T5898 pobj protein,as
R3411 T5903 T5904 punct [,17
R3412 T5904 T5881 parataxis 17,act
R3413 T5905 T5904 punct ],17
R3414 T5906 T5881 punct .,act
R3415 T5908 T5909 amod Previous,results
R3416 T5909 T5910 nsubjpass results,explained
R3417 T5911 T5912 prep in,shown
R3418 T5912 T5909 relcl shown,results
R3419 T5913 T5911 pobj which,in
R3420 T5914 T5915 compound annexin,A7
R3421 T5915 T5912 nsubjpass A7,shown
R3422 T5916 T5912 auxpass was,shown
R3423 T5917 T5918 aux to,play
R3424 T5918 T5912 xcomp play,shown
R3425 T5919 T5920 det a,role
R3426 T5920 T5918 dobj role,play
R3427 T5921 T5918 prep in,play
R3428 T5922 T5923 compound membrane,aggregation
R3429 T5923 T5921 pobj aggregation,in
R3430 T5924 T5910 aux might,explained
R3431 T5925 T5910 auxpass be,explained
R3432 T5926 T5910 agent by,explained
R3433 T5927 T5928 det a,function
R3434 T5928 T5926 pobj function,by
R3435 T5929 T5928 amod supportive,function
R3436 T5930 T5928 prep of,function
R3437 T5931 T5932 compound annexin,A7
R3438 T5932 T5930 pobj A7,of
R3439 T5933 T5934 mark in,interferes
R3440 T5934 T5910 advcl interferes,explained
R3441 T5935 T5934 mark that,interferes
R3442 T5936 T5934 nsubj it,interferes
R3443 T5937 T5934 prep with,interferes
R3444 T5938 T5939 det the,homeostasis
R3445 T5939 T5937 pobj homeostasis,with
R3446 T5940 T5939 amod local,homeostasis
R3447 T5941 T5939 compound Ca2+,homeostasis
R3448 T5942 T5943 advmod thus,influencing
R3449 T5943 T5934 advcl influencing,interferes
R3450 T5944 T5945 compound membrane,organization
R3451 T5945 T5943 dobj organization,influencing
R3452 T5946 T5910 punct .,explained
R3453 T5948 T5949 mark As,belong
R3454 T5949 T5952 advcl belong,expected
R3455 T5950 T5951 det the,annexins
R3456 T5951 T5949 nsubj annexins,belong
R3457 T5953 T5949 prep to,belong
R3458 T5954 T5955 det a,family
R3459 T5955 T5953 pobj family,to
R3460 T5956 T5957 advmod wide,spread
R3461 T5957 T5955 amod spread,family
R3462 T5958 T5957 cc and,spread
R3463 T5959 T5960 advmod evolutionarily,conserved
R3464 T5960 T5957 conj conserved,spread
R3465 T5961 T5955 compound protein,family
R3466 T5962 T5952 punct ", ",expected
R3467 T5963 T5964 npadvmod redundant,identical
R3468 T5964 T5968 amod identical,functions
R3469 T5965 T5964 punct ", ",identical
R3470 T5966 T5964 cc but,identical
R3471 T5967 T5966 neg not,but
R3472 T5968 T5952 nsubjpass functions,expected
R3473 T5969 T5952 auxpass are,expected
R3474 T5970 T5952 punct .,expected
R3475 T5972 T5973 advmod However,described
R3476 T5974 T5973 punct ", ",described
R3477 T5975 T5976 advmod so,far
R3478 T5976 T5973 advmod far,described
R3479 T5977 T5978 det no,members
R3480 T5978 T5973 nsubjpass members,described
R3481 T5979 T5978 amod other,members
R3482 T5980 T5978 prep of,members
R3483 T5981 T5982 det the,family
R3484 T5982 T5980 pobj family,of
R3485 T5983 T5982 compound annexin,family
R3486 T5984 T5982 punct ", ",family
R3487 T5985 T5986 dep which,substitute
R3488 T5986 T5982 relcl substitute,family
R3489 T5987 T5986 aux may,substitute
R3490 T5988 T5986 prep for,substitute
R3491 T5989 T5990 compound annexin,A7
R3492 T5990 T5988 pobj A7,for
R3493 T5991 T5973 punct ", ",described
R3494 T5992 T5973 aux have,described
R3495 T5993 T5973 auxpass been,described
R3496 T5994 T5973 prep in,described
R3497 T5995 T5996 amod red,cells
R3498 T5996 T5994 pobj cells,in
R3499 T5997 T5996 compound blood,cells
R3500 T5998 T5973 punct .,described
R3501 T6000 T6001 det The,basis
R3502 T6001 T6003 nsubj basis,are
R3503 T6002 T6001 amod structural,basis
R3504 T6004 T6001 prep for,basis
R3505 T6005 T6006 det the,elasticy
R3506 T6006 T6004 pobj elasticy,for
R3507 T6007 T6006 prep of,elasticy
R3508 T6008 T6009 amod red,cells
R3509 T6009 T6007 pobj cells,of
R3510 T6010 T6009 compound blood,cells
R3511 T6011 T6009 prep in,cells
R3512 T6012 T6011 pobj circulation,in
R3513 T6013 T6014 amod long,range
R3514 T6014 T6015 nmod range,functions
R3515 T6015 T6003 attr functions,are
R3516 T6016 T6015 amod molecular,functions
R3517 T6017 T6015 prep of,functions
R3518 T6018 T6019 det the,membrane
R3519 T6019 T6017 pobj membrane,of
R3520 T6020 T6019 compound plasma,membrane
R3521 T6021 T6019 cc and,membrane
R3522 T6022 T6023 det the,part
R3523 T6023 T6019 conj part,membrane
R3524 T6024 T6025 npadvmod membrane,associated
R3525 T6025 T6023 amod associated,part
R3526 T6026 T6023 prep of,part
R3527 T6027 T6028 det the,cytoskeleton
R3528 T6028 T6026 pobj cytoskeleton,of
R3529 T6029 T6030 punct [,40
R3530 T6030 T6003 parataxis 40,are
R3531 T6031 T6032 punct -,43
R3532 T6032 T6030 prep 43,40
R3533 T6033 T6030 punct ],40
R3534 T6034 T6003 punct .,are
R3535 T6036 T6037 amod Major,constituents
R3536 T6037 T6038 nsubj constituents,are
R3537 T6039 T6037 prep of,constituents
R3538 T6040 T6041 det the,skeleton
R3539 T6041 T6039 pobj skeleton,of
R3540 T6042 T6041 compound membrane,skeleton
R3541 T6043 T6044 compound spectrin,tetramers
R3542 T6044 T6038 attr tetramers,are
R3543 T6045 T6044 acl linked,tetramers
R3544 T6046 T6045 advmod together,linked
R3545 T6047 T6045 agent by,linked
R3546 T6048 T6049 amod short,filaments
R3547 T6049 T6047 pobj filaments,by
R3548 T6050 T6049 compound actin,filaments
R3549 T6051 T6049 cc and,filaments
R3550 T6052 T6053 amod several,proteins
R3551 T6053 T6049 conj proteins,filaments
R3552 T6054 T6053 amod other,proteins
R3553 T6055 T6053 acl covering,proteins
R3554 T6056 T6057 det the,surface
R3555 T6057 T6055 dobj surface,covering
R3556 T6058 T6057 amod entire,surface
R3557 T6059 T6057 amod cytoplasmic,surface
R3558 T6060 T6057 prep of,surface
R3559 T6061 T6062 det the,membrane
R3560 T6062 T6060 pobj membrane,of
R3561 T6063 T6064 amod red,cell
R3562 T6064 T6062 compound cell,membrane
R3563 T6065 T6064 compound blood,cell
R3564 T6066 T6067 punct [,44
R3565 T6067 T6038 parataxis 44,are
R3566 T6068 T6067 punct ],44
R3567 T6069 T6038 punct .,are
R3568 T6071 T6072 compound Membrane,cholesterol
R3569 T6072 T6073 nsubj cholesterol,diminishes
R3570 T6074 T6075 amod red,cell
R3571 T6075 T6077 compound cell,haemolysis
R3572 T6076 T6075 compound blood,cell
R3573 T6077 T6073 dobj haemolysis,diminishes
R3574 T6078 T6077 prep by,haemolysis
R3575 T6079 T6080 det the,complex
R3576 T6080 T6078 pobj complex,by
R3577 T6081 T6080 compound complement,complex
R3578 T6082 T6073 punct ", ",diminishes
R3579 T6083 T6084 mark whereas,abrogates
R3580 T6084 T6073 advcl abrogates,diminishes
R3581 T6085 T6084 nsubj depletion,abrogates
R3582 T6086 T6085 prep of,depletion
R3583 T6087 T6088 compound raft,cholesterol
R3584 T6088 T6086 pobj cholesterol,of
R3585 T6089 T6084 dobj association,abrogates
R3586 T6090 T6089 prep of,association
R3587 T6091 T6092 det all,proteins
R3588 T6092 T6090 pobj proteins,of
R3589 T6093 T6092 compound raft,proteins
R3590 T6094 T6084 prep with,abrogates
R3591 T6095 T6096 det no,effect
R3592 T6132 T6130 dobj resistance,have
R3593 T6096 T6094 pobj effect,with
R3594 T6097 T6096 amod significant,effect
R3595 T6098 T6096 prep on,effect
R3596 T6133 T6132 amod higher,resistance
R3597 T6099 T6098 pobj areas,on
R3598 T6134 T6132 amod osmotic,resistance
R3599 T6135 T6124 punct .,show
R3600 T6100 T6099 prep in,areas
R3601 T6137 T6138 det The,presence
R3602 T6101 T6102 det the,rest
R3603 T6138 T6139 nsubj presence,alter
R3604 T6140 T6138 prep of,presence
R3605 T6102 T6100 pobj rest,in
R3606 T6141 T6142 compound annexin,A7
R3607 T6142 T6140 pobj A7,of
R3608 T6143 T6139 aux may,alter
R3609 T6103 T6102 prep of,rest
R3610 T6144 T6145 det the,flexibility
R3611 T6145 T6139 dobj flexibility,alter
R3612 T6104 T6105 det the,membrane
R3613 T6146 T6145 compound membrane,flexibility
R3614 T6147 T6148 mark in,supports
R3615 T6148 T6139 advcl supports,alter
R3616 T6105 T6103 pobj membrane,of
R3617 T6149 T6148 mark that,supports
R3618 T6150 T6148 nsubj it,supports
R3619 T6106 T6105 compound cell,membrane
R3620 T6151 T6152 det the,shape
R3621 T6152 T6148 dobj shape,supports
R3622 T6153 T6152 amod typical,shape
R3623 T6107 T6099 cc and,areas
R3624 T6154 T6152 compound biconcave,shape
R3625 T6155 T6152 compound membrane,shape
R3626 T6108 T6099 conj deformability,areas
R3627 T6156 T6148 cc and,supports
R3628 T6157 T6148 conj leads,supports
R3629 T6158 T6157 prep to,leads
R3630 T6159 T6160 det a,resistance
R3631 T6109 T6110 punct [,46
R3632 T6160 T6158 pobj resistance,to
R3633 T6161 T6160 amod lower,resistance
R3634 T6162 T6160 amod minimal,resistance
R3635 T6163 T6160 amod osmotic,resistance
R3636 T6110 T6073 parataxis 46,diminishes
R3637 T6164 T6139 punct .,alter
R3638 T6166 T6167 compound Annexin,A7
R3639 T6167 T6168 nsubj A7,appear
R3640 T6111 T6110 nummod 45,46
R3641 T6169 T6168 aux does,appear
R3642 T6170 T6168 neg not,appear
R3643 T6112 T6110 punct ",",46
R3644 T6171 T6172 aux to,have
R3645 T6172 T6168 xcomp have,appear
R3646 T6173 T6174 det an,influence
R3647 T6113 T6110 punct ],46
R3648 T6174 T6172 dobj influence,have
R3649 T6175 T6174 prep on,influence
R3650 T6114 T6073 punct .,diminishes
R3651 T6176 T6177 compound plasma,membrane
R3652 T6177 T6178 compound membrane,integrity
R3653 T6178 T6175 pobj integrity,on
R3654 T6116 T6117 nmod Annexin,A7
R3655 T6179 T6178 appos itself,integrity
R3656 T6180 T6181 mark as,stays
R3657 T6181 T6172 advcl stays,have
R3658 T6182 T6183 det the,value
R3659 T6117 T6118 nmod A7,cells
R3660 T6183 T6181 nsubj value,stays
R3661 T6184 T6183 amod maximal,value
R3662 T6185 T6186 amod osmotic,resistance
R3663 T6118 T6124 nsubj cells,show
R3664 T6186 T6183 compound resistance,value
R3665 T6187 T6181 acomp constant,stays
R3666 T6188 T6168 punct .,appear
R3667 T6119 T6120 nmod knock,out
R3668 T6190 T6191 nmod Ca2+,proteins
R3669 T6120 T6121 nmod out,mouse
R3670 T6191 T6195 nsubjpass proteins,known
R3671 T6192 T6190 cc and,Ca2+
R3672 T6193 T6194 npadvmod membrane,skeletal
R3673 T6121 T6118 nmod mouse,cells
R3674 T6194 T6190 conj skeletal,Ca2+
R3675 T6122 T6118 amod red,cells
R3676 T6196 T6195 auxpass are,known
R3677 T6197 T6198 aux to,play
R3678 T6198 T6195 xcomp play,known
R3679 T6123 T6118 compound blood,cells
R3680 T6199 T6200 amod key,roles
R3681 T6200 T6198 dobj roles,play
R3682 T6125 T6126 det a,shape
R3683 T6201 T6198 prep on,play
R3684 T6202 T6203 det the,shape
R3685 T6203 T6201 pobj shape,on
R3686 T6204 T6205 amod red,cell
R3687 T6205 T6203 compound cell,shape
R3688 T6206 T6205 compound blood,cell
R3689 T6126 T6124 dobj shape,show
R3690 T6127 T6128 advmod more,flat
R3691 T6207 T6203 compound membrane,shape
R3692 T6208 T6203 cc and,shape
R3693 T6209 T6203 conj stability,shape
R3694 T6128 T6126 amod flat,shape
R3695 T6210 T6211 punct [,47
R3696 T6211 T6195 parataxis 47,known
R3697 T6129 T6124 cc and,show
R3698 T6212 T6211 punct ],47
R3699 T6213 T6195 punct .,known
R3700 T6215 T6216 nsubjpass Annexins,reported
R3701 T6130 T6124 conj have,show
R3702 T6216 T6219 ccomp reported,exclude
R3703 T6217 T6216 aux have,reported
R3704 T6131 T6132 det a,resistance
R3705 T6218 T6216 auxpass been,reported
R3706 T6220 T6221 aux to,bind
R3707 T6239 T6240 advmod Nevertheless,interact
R3708 T6221 T6216 xcomp bind,reported
R3709 T6222 T6221 advmod directly,bind
R3710 T6223 T6221 prep to,bind
R3711 T6224 T6225 compound F,actin
R3712 T6225 T6223 pobj actin,to
R3713 T6226 T6225 punct -,actin
R3714 T6241 T6240 nsubj it,interact
R3715 T6227 T6219 punct ", ",exclude
R3716 T6228 T6219 nsubj we,exclude
R3717 T6229 T6219 aux could,exclude
R3718 T6230 T6219 advmod however,exclude
R3719 T6242 T6240 aux might,interact
R3720 T6231 T6232 amod such,activity
R3721 T6232 T6219 dobj activity,exclude
R3722 T6243 T6240 prep with,interact
R3723 T6233 T6232 det an,activity
R3724 T6234 T6219 prep for,exclude
R3725 T6244 T6245 amod other,components
R3726 T6235 T6236 compound annexin,A7
R3727 T6236 T6234 pobj A7,for
R3728 T6237 T6219 punct .,exclude
R3729 T6245 T6243 pobj components,with
R3730 T6246 T6240 cc and,interact
R3731 T6247 T6240 conj have,interact
R3732 T6248 T6249 det a,role
R3733 T6249 T6247 dobj role,have
R3734 T6344 T6345 amod cytoskeletal,protein
R3735 T6250 T6247 prep in,have
R3736 T6345 T6346 compound protein,interactions
R3737 T6346 T6343 pobj interactions,of
R3738 T6347 T6348 punct [,50
R3739 T6348 T6330 parataxis 50,shown
R3740 T6349 T6348 punct ],50
R3741 T6350 T6330 punct .,shown
R3742 T6251 T6250 pcomp organizing,in
R3743 T6352 T6353 nsubj Ca2+,induces
R3744 T6252 T6253 det the,cytoskeleton
R3745 T6354 T6353 advmod also,induces
R3746 T6355 T6356 det a,redistribution
R3747 T6356 T6353 dobj redistribution,induces
R3748 T6253 T6251 dobj cytoskeleton,organizing
R3749 T6357 T6356 compound transbilayer,redistribution
R3750 T6358 T6356 compound phospholipid,redistribution
R3751 T6254 T6253 compound membrane,cytoskeleton
R3752 T6359 T6356 acl inducing,redistribution
R3753 T6360 T6361 det a,change
R3754 T6361 T6359 dobj change,inducing
R3755 T6255 T6240 punct ", ",interact
R3756 T6362 T6361 compound shape,change
R3757 T6363 T6361 prep of,change
R3758 T6256 T6240 advcl controlling,interact
R3759 T6364 T6365 amod red,cells
R3760 T6365 T6363 pobj cells,of
R3761 T6366 T6365 compound blood,cells
R3762 T6257 T6258 compound raft,protein
R3763 T6367 T6368 punct [,51
R3764 T6368 T6353 parataxis 51,induces
R3765 T6369 T6368 punct ],51
R3766 T6258 T6259 compound protein,associations
R3767 T6370 T6353 punct .,induces
R3768 T6372 T6373 prep In,drive
R3769 T6259 T6256 dobj associations,controlling
R3770 T6374 T6372 pobj addition,In
R3771 T6260 T6256 cc or,controlling
R3772 T6375 T6373 punct ", ",drive
R3773 T6376 T6377 compound Ca2+,ions
R3774 T6377 T6373 nsubj ions,drive
R3775 T6261 T6256 conj influencing,controlling
R3776 T6378 T6373 aux can,drive
R3777 T6379 T6373 dobj spiculation,drive
R3778 T6380 T6379 prep of,spiculation
R3779 T6381 T6382 det the,bilayer
R3780 T6262 T6263 det the,strength
R3781 T6382 T6380 pobj bilayer,of
R3782 T6383 T6382 compound membrane,bilayer
R3783 T6263 T6261 dobj strength,influencing
R3784 T6384 T6373 prep without,drive
R3785 T6385 T6384 pcomp involving,without
R3786 T6386 T6387 det the,cytoskeleton
R3787 T6264 T6263 amod ionic,strength
R3788 T6387 T6385 dobj cytoskeleton,involving
R3789 T6388 T6389 punct [,52
R3790 T6389 T6373 parataxis 52,drive
R3791 T6390 T6389 punct ],52
R3792 T6391 T6373 punct .,drive
R3793 T6265 T6263 prep of,strength
R3794 T6393 T6394 nsubj We,observed
R3795 T6266 T6267 amod red,cells
R3796 T6395 T6394 aux have,observed
R3797 T6396 T6394 advmod also,observed
R3798 T6397 T6398 det a,defect
R3799 T6267 T6265 pobj cells,of
R3800 T6268 T6267 compound blood,cells
R3801 T6398 T6394 dobj defect,observed
R3802 T6269 T6256 prep on,controlling
R3803 T6399 T6398 prep in,defect
R3804 T6270 T6271 poss its,own
R3805 T6400 T6401 compound platelet,function
R3806 T6401 T6399 pobj function,in
R3807 T6402 T6394 prep in,observed
R3808 T6403 T6404 det the,mutant
R3809 T6271 T6269 pobj own,on
R3810 T6404 T6402 pobj mutant,in
R3811 T6405 T6406 compound annexin,A7
R3812 T6406 T6404 compound A7,mutant
R3813 T6272 T6269 cc or,on
R3814 T6407 T6394 punct .,observed
R3815 T6273 T6269 conj by,on
R3816 T6409 T6410 prep In,was
R3817 T6411 T6412 det the,experiments
R3818 T6274 T6273 pcomp interfering,by
R3819 T6412 T6409 pobj experiments,In
R3820 T6413 T6414 compound platelet,aggregation
R3821 T6414 T6412 compound aggregation,experiments
R3822 T6275 T6274 prep with,interfering
R3823 T6415 T6416 det the,velocity
R3824 T6416 T6410 nsubj velocity,was
R3825 T6417 T6416 amod initial,velocity
R3826 T6276 T6277 amod other,pathways
R3827 T6418 T6416 compound aggregation,velocity
R3828 T6419 T6420 advmod slightly,lower
R3829 T6277 T6275 pobj pathways,with
R3830 T6420 T6410 acomp lower,was
R3831 T6421 T6419 punct ", ",slightly
R3832 T6422 T6419 cc but,slightly
R3833 T6423 T6419 conj significantly,slightly
R3834 T6278 T6277 compound signaling,pathways
R3835 T6424 T6410 prep in,was
R3836 T6425 T6424 pobj platelets,in
R3837 T6279 T6240 punct .,interact
R3838 T6426 T6425 acl lacking,platelets
R3839 T6427 T6428 compound annexin,A7
R3840 T6428 T6426 dobj A7,lacking
R3841 T6281 T6282 mark As,discussed
R3842 T6429 T6410 punct .,was
R3843 T6431 T6432 det These,data
R3844 T6432 T6433 nsubjpass data,reflected
R3845 T6434 T6433 auxpass are,reflected
R3846 T6435 T6433 neg not,reflected
R3847 T6282 T6283 advcl discussed,involved
R3848 T6436 T6433 agent by,reflected
R3849 T6437 T6438 det a,change
R3850 T6438 T6436 pobj change,by
R3851 T6284 T6282 advmod above,discussed
R3852 T6439 T6438 prep in,change
R3853 T6440 T6441 det the,time
R3854 T6441 T6439 pobj time,in
R3855 T6442 T6443 advmod in,vivo
R3856 T6285 T6286 compound annexin,A7
R3857 T6443 T6441 amod vivo,time
R3858 T6444 T6441 compound bleeding,time
R3859 T6445 T6433 punct .,reflected
R3860 T6286 T6283 nsubjpass A7,involved
R3861 T6447 T6448 advmod However,is
R3862 T6449 T6450 det the,speed
R3863 T6287 T6283 aux could,involved
R3864 T6288 T6283 auxpass be,involved
R3865 T6289 T6283 prep in,involved
R3866 T6290 T6291 det the,homeostasis
R3867 T6291 T6289 pobj homeostasis,in
R3868 T6292 T6293 amod cytoplasmic,Ca2+
R3869 T6450 T6448 nsubj speed,is
R3870 T6293 T6291 compound Ca2+,homeostasis
R3871 T6451 T6450 compound reaction,speed
R3872 T6452 T6450 prep of,speed
R3873 T6294 T6283 punct .,involved
R3874 T6453 T6454 amod murine,platelets
R3875 T6454 T6452 pobj platelets,of
R3876 T6296 T6297 nsubjpass It,demonstrated
R3877 T6455 T6456 advmod much,higher
R3878 T6456 T6448 acomp higher,is
R3879 T6457 T6456 prep than,higher
R3880 T6458 T6457 pobj those,than
R3881 T6298 T6297 aux has,demonstrated
R3882 T6459 T6458 prep of,those
R3883 T6460 T6459 pobj human,of
R3884 T6461 T6448 cc and,is
R3885 T6462 T6463 prep due,missed
R3886 T6299 T6297 auxpass been,demonstrated
R3887 T6463 T6448 conj missed,is
R3888 T6464 T6462 pcomp to,due
R3889 T6300 T6301 mark that,exert
R3890 T6465 T6466 det the,setup
R3891 T6466 T6462 pobj setup,due
R3892 T6467 T6466 amod technical,setup
R3893 T6301 T6297 ccomp exert,demonstrated
R3894 T6468 T6463 nsubj we,missed
R3895 T6469 T6463 aux might,missed
R3896 T6470 T6463 aux have,missed
R3897 T6471 T6472 amod larger,changes
R3898 T6472 T6463 dobj changes,missed
R3899 T6473 T6463 prep in,missed
R3900 T6302 T6303 amod micromolar,changes
R3901 T6474 T6475 det the,samples
R3902 T6475 T6473 pobj samples,in
R3903 T6476 T6475 compound mouse,samples
R3904 T6303 T6301 nsubj changes,exert
R3905 T6477 T6463 punct .,missed
R3906 T6304 T6303 prep of,changes
R3907 T6479 T6480 det The,reaction
R3908 T6480 T6482 nsubjpass reaction,caused
R3909 T6481 T6480 amod immediate,reaction
R3910 T6305 T6306 det the,concentration
R3911 T6483 T6480 prep of,reaction
R3912 T6306 T6304 pobj concentration,of
R3913 T6484 T6485 compound mouse,platelets
R3914 T6485 T6483 pobj platelets,of
R3915 T6307 T6306 amod intracellular,concentration
R3916 T6486 T6480 cc and,reaction
R3917 T6308 T6306 compound Ca2+,concentration
R3919 T6309 T6310 det a,effect
R3920 T6488 T6480 conj absence,reaction
R3921 T6489 T6488 prep of,absence
R3922 T6310 T6301 dobj effect,exert
R3923 T6490 T6491 det a,phase
R3924 T6491 T6489 pobj phase,of
R3925 T6492 T6491 compound lag,phase
R3926 T6493 T6491 prep after,phase
R3927 T6311 T6310 amod profound,effect
R3928 T6494 T6493 pobj triggering,after
R3929 T6495 T6482 aux may,caused
R3930 T6312 T6310 prep on,effect
R3931 T6496 T6482 auxpass be,caused
R3932 T6497 T6482 agent by,caused
R3933 T6313 T6314 det the,properties
R3934 T6498 T6499 det an,generation
R3935 T6499 T6497 pobj generation,by
R3936 T6500 T6501 advmod immediately,initiated
R3937 T6314 T6312 pobj properties,on
R3938 T6501 T6499 amod initiated,generation
R3939 T6502 T6499 compound thrombin,generation
R3940 T6315 T6314 compound membrane,properties
R3941 T6503 T6504 punct [,22
R3942 T6504 T6482 parataxis 22,caused
R3943 T6505 T6504 punct ],22
R3944 T6316 T6317 dep that,regulate
R3945 T6506 T6482 punct .,caused
R3946 T6508 T6509 mark As,known
R3947 T6509 T6510 advcl known,are
R3948 T6511 T6509 prep from,known
R3949 T6317 T6314 relcl regulate,properties
R3950 T6512 T6513 det the,syndrome
R3951 T6513 T6511 pobj syndrome,from
R3952 T6514 T6513 amod frequent,syndrome
R3953 T6318 T6319 amod red,cell
R3954 T6515 T6513 amod human,syndrome
R3955 T6516 T6513 compound vWF,syndrome
R3956 T6517 T6513 punct -,syndrome
R3957 T6319 T6321 compound cell,deformability
R3958 T6518 T6513 cc or,syndrome
R3959 T6519 T6520 amod other,diseases
R3960 T6320 T6319 compound blood,cell
R3961 T6520 T6513 conj diseases,syndrome
R3962 T6521 T6520 amod haemostatic,diseases
R3963 T6522 T6510 punct ", ",are
R3964 T6321 T6317 dobj deformability,regulate
R3965 T6523 T6524 amod small,defects
R3966 T6524 T6510 nsubj defects,are
R3967 T6322 T6323 punct [,49
R3968 T6525 T6510 advmod often,are
R3969 T6526 T6527 advmod clinically,silent
R3970 T6527 T6510 acomp silent,are
R3971 T6323 T6297 parataxis 49,demonstrated
R3972 T6528 T6510 cc and,are
R3973 T6529 T6530 aux do,result
R3974 T6324 T6323 nummod 48,49
R3975 T6530 T6510 conj result,are
R3976 T6531 T6530 neg not,result
R3977 T6532 T6530 prep in,result
R3978 T6533 T6534 amod physiological,changes
R3979 T6325 T6323 punct ",",49
R3980 T6534 T6532 pobj changes,in
R3981 T6535 T6510 prep under,are
R3982 T6326 T6323 punct ],49
R3983 T6536 T6537 amod normal,conditions
R3984 T6537 T6535 pobj conditions,under
R3985 T6538 T6510 punct .,are
R3986 T6327 T6297 punct .,demonstrated
R3987 T6540 T6541 advmod Only,in
R3988 T6541 T6542 prep in,become
R3989 T6329 T6330 advmod Furthermore,shown
R3990 T6543 T6541 pobj situations,in
R3991 T6544 T6543 prep with,situations
R3992 T6545 T6546 amod severe,injury
R3993 T6331 T6330 punct ", ",shown
R3994 T6546 T6544 pobj injury,with
R3995 T6547 T6546 amod physical,injury
R3996 T6548 T6542 punct ", ",become
R3997 T6549 T6550 amod distinct,influences
R3998 T6550 T6542 nsubj influences,become
R3999 T6551 T6550 amod environmental,influences
R4000 T6552 T6550 cc or,influences
R4001 T6332 T6333 det the,Ca2+
R4002 T6553 T6554 amod additional,platelet
R4003 T6554 T6550 conj platelet,influences
R4004 T6555 T6554 nmod attributes,platelet
R4005 T6333 T6330 nsubjpass Ca2+,shown
R4006 T6334 T6333 amod intracellular,Ca2+
R4007 T6335 T6330 auxpass was,shown
R4008 T6556 T6554 prep like,platelet
R4009 T6557 T6558 det the,differences
R4010 T6336 T6337 aux to,regulate
R4011 T6558 T6556 pobj differences,like
R4012 T6559 T6560 nmod platelet,antigen
R4013 T6337 T6330 xcomp regulate,shown
R4014 T6560 T6558 nmod antigen,differences
R4015 T6561 T6558 nmod polymorphism,differences
R4016 T6562 T6563 punct [,53
R4017 T6338 T6339 det the,stability
R4018 T6563 T6558 parataxis 53,differences
R4019 T6564 T6563 punct ],53
R4020 T6565 T6542 aux might,become
R4021 T6339 T6337 dobj stability,regulate
R4022 T6566 T6542 acomp apparent,become
R4023 T6567 T6542 punct .,become
R4024 T6340 T6339 compound membrane,stability
R4025 T6341 T6337 prep through,regulate
R4026 T6342 T6341 pobj modulation,through
R4027 T6343 T6342 prep of,modulation
R3918 T6487 T6488 det the,absence

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4727 11-21 PR:000004080 denotes Annexin A7
T4728 51-58 GO:0031982 denotes vesicle
T4729 51-65 GO:0006906 denotes vesicle fusion
T4730 73-83 GO:0065007 denotes regulating
T4731 100-116 GO:0044425 denotes membrane domains
T4732 160-175 GO:0005886 denotes plasma membrane
T4733 186-201 GO:0045121 denotes raft subdomains
T4734 236-243 GO:0005829 denotes cytosol
T4735 277-284 GO:0031982 denotes vesicle
T4736 353-359 UBERON:0000479 denotes tissue
T4737 434-444 GO:0010467 denotes expression
T4738 498-506 SO:0001060 denotes isoforms
T4739 516-525 GO:0010467 denotes expressed
T4740 537-552 CL:0000232 denotes Red blood cells
T4741 541-546 UBERON:0000178 denotes blood
T4742 589-599 PR:000004080 denotes annexin A7
T4743 642-649 SO:0001060 denotes isoform
T4744 684-690 PR:000015619 denotes sorcin
T4745 733-740 SO:0001060 denotes isoform
T4746 757-772 CL:0000232 denotes red blood cells
T4747 761-766 UBERON:0000178 denotes blood
T4748 811-818 SO:0001060 denotes isoform
T4749 876-886 PR:000004080 denotes annexin A7
T4750 890-905 CL:0000232 denotes red blood cells
T4751 894-899 UBERON:0000178 denotes blood
T4752 929-939 PR:000004080 denotes annexin A7
T4753 944-950 PR:000015619 denotes sorcin
T4754 968-989 GO:0045121 denotes membrane raft domains
T4755 997-1005 GO:0031982 denotes vesicles
T4756 1018-1033 CL:0000232 denotes red blood cells
T4757 1022-1027 UBERON:0000178 denotes blood
T4758 1044-1056 GO:0045121 denotes Raft domains
T4759 1098-1106 GO:0016020 denotes membrane
T4760 1141-1153 GO:0006900 denotes vesiculation
T4761 1198-1211 CHEBI:26739 denotes sphingolipids
T4762 1216-1227 CHEBI:16113 denotes cholesterol
T4763 1241-1251 _FRAGMENT denotes leaflet of
T4764 1256-1264 GO:0097478 denotes membrane
T4765 1278-1291 CHEBI:16247 denotes phospholipids
T4766 1296-1307 CHEBI:16113 denotes cholesterol
T4767 1321-1328 GO:0097478 denotes leaflet
T4768 1381-1386 GO:0045121 denotes rafts
T4769 1402-1411 GO:0016020 denotes membranes
T4770 1453-1465 CHEBI:9750 denotes Triton X-100
T4771 1505-1512 CHEBI:17992 denotes sucrose
T4772 1583-1593 PR:000004080 denotes annexin A7
T4773 1603-1611 GO:0016020 denotes membrane
T4774 1644-1654 PR:000004080 denotes annexin A7
T4775 1688-1700 GO:0006900 denotes vesiculation
T4776 1756-1768 GO:0006900 denotes vesiculation
T4777 1802-1812 PR:000004080 denotes annexin A7
T4778 1888-1898 CHEBI:35195 denotes surfactant
T4779 1902-1912 PR:000004080 denotes annexin A7
T4780 1970-1980 PR:000004080 denotes annexin A7
T4781 1984-1994 CHEBI:35195 denotes surfactant
T4782 2027-2037 PR:000004080 denotes annexin A7
T4783 2047-2055 GO:0016020 denotes membrane
T4784 2047-2062 GO:0061025 denotes membrane fusion
T4785 2131-2141 PR:000004080 denotes annexin A7
T4786 2151-2156 NCBITaxon:10088 denotes mouse
T4787 2186-2196 PR:000004080 denotes annexin A7
T4788 2200-2210 _FRAGMENT denotes budding of
T4789 2226-2234 GO:0006900 denotes vesicles
T4790 2211-2225 CL:0000232 denotes red blood cell
T4791 2215-2220 UBERON:0000178 denotes blood
T4792 2226-2234 GO:0031982 denotes vesicles
T4793 2276-2282 _FRAGMENT denotes micro-
T4794 2291-2298 GO:1990742 denotes vesicle
T4795 2364-2379 CL:0000232 denotes red blood cells
T4796 2368-2373 UBERON:0000178 denotes blood
T4797 2391-2415 NCBITaxon:44689 denotes Dictyostelium discoideum
T4798 2451-2455 SO:0000704 denotes gene
T4799 2514-2522 GO:0016020 denotes membrane
T4800 2514-2529 GO:0061025 denotes membrane fusion
T4801 2605-2617 CHEBI:16247 denotes phospholipid
T4802 2628-2638 PR:000004080 denotes annexin A7
T4803 2663-2667 CHEBI:29108 denotes Ca2+
T4804 2755-2765 PR:000004080 denotes annexin A7
T4805 2769-2775 _FRAGMENT denotes micro-
T4806 2784-2792 GO:1990742 denotes vesicles
T4807 2848-2862 CL:0000232 denotes red blood cell
T4808 2852-2857 UBERON:0000178 denotes blood
T4809 2858-2871 GO:0005886 denotes cell membrane
T4810 2884-2894 PR:000004080 denotes annexin A7
T4811 2915-2919 CHEBI:29108 denotes Ca2+
T4812 2976-2987 GO:0070382 denotes exovesicles
T4813 3027-3037 PR:000004080 denotes annexin A7
T4814 3038-3046 SO:0001060 denotes isoforms
T4815 3063-3078 CL:0000232 denotes red blood cells
T4816 3067-3072 UBERON:0000178 denotes blood
T4817 3142-3151 GO:0016020 denotes membranes
T4818 3155-3163 GO:0016020 denotes membrane
T4819 3182-3192 PR:000004075 denotes annexin A2
T4820 3220-3229 GO:0005768 denotes endosomes
T4821 3256-3264 GO:0016020 denotes membrane
T4822 3256-3271 GO:0061025 denotes membrane fusion
T4823 3280-3289 GO:0005768 denotes endosomal
T4824 3299-3309 PR:000004080 denotes annexin A7
T4825 3327-3355 GO:0044853 denotes plasma membrane raft domains
T4826 3408-3416 GO:0031982 denotes vesicles
T4827 3420-3435 CL:0000232 denotes red blood cells
T4828 3424-3429 UBERON:0000178 denotes blood
T4829 3444-3454 PR:000004080 denotes annexin A7
T4830 3469-3475 PR:000015619 denotes sorcin
T4831 3548-3558 PR:000004080 denotes annexin A7
T4832 3566-3576 GO:0010467 denotes expression
T4833 3584-3598 CL:0000232 denotes red blood cell
T4834 3584-3610 GO:0048821 denotes red blood cell development
T4835 3588-3593 UBERON:0000178 denotes blood
T4836 3657-3664 GO:0031982 denotes vesicle
T4837 3657-3674 GO:0006900 denotes vesicle formation
T4838 3679-3687 GO:0016020 denotes membrane
T4839 3679-3694 GO:0061025 denotes membrane fusion
T4840 3696-3706 PR:000004080 denotes annexin A7
T4841 3736-3740 CHEBI:29108 denotes Ca2+
T4842 3789-3799 PR:000004080 denotes annexin A7
T4843 3828-3836 GO:0016020 denotes membrane
T4844 3896-3906 PR:000004080 denotes annexin A7
T4845 3944-3948 CHEBI:29108 denotes Ca2+
T4846 3949-3960 GO:0042592 denotes homeostasis
T4847 3978-3986 GO:0016020 denotes membrane
T4848 4220-4230 PR:000004080 denotes annexin A7
T4849 4255-4270 CL:0000232 denotes red blood cells
T4850 4259-4264 UBERON:0000178 denotes blood
T4851 4313-4328 CL:0000232 denotes red blood cells
T4852 4317-4322 UBERON:0000178 denotes blood
T4853 4386-4401 GO:0005886 denotes plasma membrane
T4854 4410-4418 GO:0016020 denotes membrane
T4855 4430-4437 _FRAGMENT denotes part of
T4856 4442-4454 GO:0044430 denotes cytoskeleton
T4857 4490-4498 GO:0016020 denotes membrane
T4858 4499-4507 GO:0005856 denotes skeleton
T4859 4556-4571 GO:0005884 denotes actin filaments
T4860 4619-4641 _FRAGMENT denotes cytoplasmic surface of
T4861 4656-4669 GO:0009898 denotes cell membrane
T4862 4646-4660 CL:0000232 denotes red blood cell
T4863 4650-4655 UBERON:0000178 denotes blood
T4864 4676-4684 GO:0016020 denotes Membrane
T4865 4685-4696 CHEBI:16113 denotes cholesterol
T4866 4708-4722 CL:0000232 denotes red blood cell
T4867 4712-4717 UBERON:0000178 denotes blood
T4868 4741-4759 GO:0005579 denotes complement complex
T4869 4782-4786 GO:0045121 denotes raft
T4870 4787-4798 CHEBI:16113 denotes cholesterol
T4871 4828-4832 GO:0045121 denotes raft
T4872 4897-4910 GO:0005886 denotes cell membrane
T4873 4938-4948 PR:000004080 denotes Annexin A7
T4874 4959-4964 NCBITaxon:10088 denotes mouse
T4875 4965-4980 CL:0000232 denotes red blood cells
T4876 4969-4974 UBERON:0000178 denotes blood
T4877 5058-5068 PR:000004080 denotes annexin A7
T4878 5083-5091 GO:0016020 denotes membrane
T4879 5146-5154 GO:0016020 denotes membrane
T4880 5210-5220 PR:000004080 denotes Annexin A7
T4881 5261-5276 GO:0005886 denotes plasma membrane
T4882 5350-5354 CHEBI:29108 denotes Ca2+
T4883 5359-5367 GO:0016020 denotes membrane
T4884 5368-5376 GO:0005856 denotes skeletal
T4885 5421-5435 CL:0000232 denotes red blood cell
T4886 5425-5430 UBERON:0000178 denotes blood
T4887 5431-5444 GO:0005886 denotes cell membrane
T4888 5519-5526 GO:0031941 denotes F-actin
T4889 5574-5584 PR:000004080 denotes annexin A7
T4890 5673-5681 GO:0016020 denotes membrane
T4891 5682-5694 GO:0005856 denotes cytoskeleton
T4892 5696-5707 GO:0065007 denotes controlling
T4893 5708-5712 GO:0045121 denotes raft
T4894 5753-5758 CHEBI:24870 denotes ionic
T4895 5771-5786 CL:0000232 denotes red blood cells
T4896 5775-5780 UBERON:0000178 denotes blood
T4897 5866-5876 PR:000004080 denotes annexin A7
T4898 5902-5913 GO:0005737 denotes cytoplasmic
T4899 5914-5918 CHEBI:29108 denotes Ca2+
T4900 5919-5930 GO:0042592 denotes homeostasis
T4901 5988-6001 GO:0005622 denotes intracellular
T4902 6002-6006 CHEBI:29108 denotes Ca2+
T4903 6052-6060 GO:0016020 denotes membrane
T4904 6077-6085 GO:0065007 denotes regulate
T4905 6086-6100 CL:0000232 denotes red blood cell
T4906 6090-6095 UBERON:0000178 denotes blood
T4907 6141-6154 GO:0005622 denotes intracellular
T4908 6155-6159 CHEBI:29108 denotes Ca2+
T4909 6173-6181 GO:0065007 denotes regulate
T4910 6186-6194 GO:0016020 denotes membrane
T4911 6213-6223 GO:0065007 denotes modulation
T4912 6227-6239 GO:0005856 denotes cytoskeletal
T4913 6267-6271 CHEBI:29108 denotes Ca2+
T4914 6300-6312 CHEBI:16247 denotes phospholipid
T4915 6355-6370 CL:0000232 denotes red blood cells
T4916 6359-6364 UBERON:0000178 denotes blood
T4917 6390-6399 CHEBI:29108 denotes Ca2+ ions
T4918 6429-6437 GO:0016020 denotes membrane
T4919 6468-6480 GO:0005856 denotes cytoskeleton
T4920 6521-6529 CL:0000233 denotes platelet
T4921 6546-6556 PR:000004080 denotes annexin A7
T4922 6572-6580 CL:0000233 denotes platelet
T4923 6572-6592 GO:0070527 denotes platelet aggregation
T4924 6679-6688 CL:0000233 denotes platelets
T4925 6697-6707 PR:000004080 denotes annexin A7
T4926 6810-6816 NCBITaxon:39107 denotes murine
T4927 6817-6826 CL:0000233 denotes platelets
T4928 6856-6861 NCBITaxon:9606 denotes human
T4929 6936-6941 NCBITaxon:10088 denotes mouse
T4930 6977-6982 NCBITaxon:10088 denotes mouse
T4931 6983-6992 CL:0000233 denotes platelets
T4932 7083-7091 CHEBI:9574 denotes thrombin
T4933 7136-7141 NCBITaxon:9606 denotes human
T4934 7142-7145 PR:000017364 denotes vWF
T4935 7164-7175 GO:0007599 denotes haemostatic
T4936 7392-7400 CL:0000233 denotes platelet
T4937 7421-7429 CL:0000233 denotes platelet
T4938 7430-7437 CHEBI:59132 denotes antigen
R2756 T4794 T4793 _lexicallyChainedTo vesicle,micro-
R2757 T4806 T4805 _lexicallyChainedTo vesicles,micro-
R2758 T4856 T4855 _lexicallyChainedTo cytoskeleton,part of
R2759 T4861 T4860 _lexicallyChainedTo cell membrane,cytoplasmic surface of
R2754 T4764 T4763 _lexicallyChainedTo membrane,leaflet of
R2755 T4789 T4788 _lexicallyChainedTo vesicles,budding of

2_test

Id Subject Object Predicate Lexical cue
12925238-632306-8102400 118-119 632306 denotes 1
12925238-11338180-8102401 527-528 11338180 denotes 6
12925238-1825209-8102402 529-531 1825209 denotes 34
12925238-10672515-8102403 532-534 10672515 denotes 35
12925238-11895795-8102404 692-693 11895795 denotes 7
12925238-11895795-8102405 835-836 11895795 denotes 7
12925238-12208858-8102406 1538-1540 12208858 denotes 36
12925238-8855260-8102407 1574-1576 8855260 denotes 37
12925238-11290524-8102408 2116-2118 11290524 denotes 38
12925238-7657724-8102409 2532-2534 7657724 denotes 39
12925238-11390641-8102410 3758-3760 11390641 denotes 17
12925238-3862123-8102411 4456-4458 3862123 denotes 40
12925238-1540701-8102411 4456-4458 1540701 denotes 40
12925238-8211222-8102411 4456-4458 8211222 denotes 40
12925238-8434261-8102412 4671-4673 8434261 denotes 44
12925238-9761744-8102413 4930-4932 9761744 denotes 45
12925238-11352913-8102414 4933-4935 11352913 denotes 46
12925238-1398703-8102415 5466-5468 1398703 denotes 47
12925238-154737-8102416 6116-6118 154737 denotes 48
12925238-9435486-8102417 6119-6121 9435486 denotes 49
12925238-3403710-8102418 6262-6264 3403710 denotes 50
12925238-8003498-8102419 6372-6374 8003498 denotes 51
12925238-7131536-8102420 6482-6484 7131536 denotes 52
12925238-11713907-8102421 7104-7106 11713907 denotes 22

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4939 11-21 PR_EXT:000004080 denotes Annexin A7
T4940 51-58 GO:0031982 denotes vesicle
T4941 51-65 GO:0006906 denotes vesicle fusion
T4942 73-83 GO:0065007 denotes regulating
T4943 100-116 GO:0044425 denotes membrane domains
T4944 126-133 CHEBI_PR_EXT:protein denotes protein
T4945 160-175 GO:0005886 denotes plasma membrane
T4946 186-201 GO:0045121 denotes raft subdomains
T4947 236-243 GO:0005829 denotes cytosol
T4948 265-276 GO_UBERON_EXT:cellular_component_or_cell_part denotes subcellular
T4949 268-276 CL_GO_EXT:cell denotes cellular
T4950 277-284 GO:0031982 denotes vesicle
T4951 353-359 UBERON:0000479 denotes tissue
T4952 363-367 CL_GO_EXT:cell denotes cell
T4953 412-426 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T4954 427-432 CL_GO_EXT:cell denotes cells
T4955 434-444 GO:0010467 denotes expression
T4956 498-506 SO_EXT:0001060 denotes isoforms
T4957 516-525 GO:0010467 denotes expressed
T4958 537-552 CL:0000232 denotes Red blood cells
T4959 541-546 UBERON:0000178 denotes blood
T4960 547-552 CL_GO_EXT:cell denotes cells
T4961 589-599 PR_EXT:000004080 denotes annexin A7
T4962 642-649 SO_EXT:0001060 denotes isoform
T4963 668-675 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T4964 684-690 PR_EXT:000015619 denotes sorcin
T4965 733-740 SO_EXT:0001060 denotes isoform
T4966 757-772 CL:0000232 denotes red blood cells
T4967 761-766 UBERON:0000178 denotes blood
T4968 767-772 CL_GO_EXT:cell denotes cells
T4969 788-793 CL_GO_EXT:cell denotes cells
T4970 811-818 SO_EXT:0001060 denotes isoform
T4971 876-886 PR_EXT:000004080 denotes annexin A7
T4972 890-905 CL:0000232 denotes red blood cells
T4973 894-899 UBERON:0000178 denotes blood
T4974 900-905 CL_GO_EXT:cell denotes cells
T4975 929-939 PR_EXT:000004080 denotes annexin A7
T4976 944-950 PR_EXT:000015619 denotes sorcin
T4977 968-989 GO:0045121 denotes membrane raft domains
T4978 997-1005 GO:0031982 denotes vesicles
T4979 1018-1033 CL:0000232 denotes red blood cells
T4980 1022-1027 UBERON:0000178 denotes blood
T4981 1028-1033 CL_GO_EXT:cell denotes cells
T4982 1044-1056 GO:0045121 denotes Raft domains
T4983 1098-1106 GO:0016020 denotes membrane
T4984 1141-1153 GO:0006900 denotes vesiculation
T4985 1198-1211 CHEBI:26739 denotes sphingolipids
T4986 1216-1227 CHEBI:16113 denotes cholesterol
T4987 1241-1251 _FRAGMENT denotes leaflet of
T4988 1256-1264 GO:0097478 denotes membrane
T4989 1278-1291 CHEBI:16247 denotes phospholipids
T4990 1296-1307 CHEBI:16113 denotes cholesterol
T4991 1321-1328 GO:0097478 denotes leaflet
T4992 1357-1365 CHEBI_PR_EXT:protein denotes proteins
T4993 1367-1380 CHEBI_EXT:biochemical denotes Biochemically
T4994 1381-1386 GO:0045121 denotes rafts
T4995 1402-1411 GO:0016020 denotes membranes
T4996 1453-1465 CHEBI:9750 denotes Triton X-100
T4997 1505-1512 CHEBI:17992 denotes sucrose
T4998 1583-1593 PR_EXT:000004080 denotes annexin A7
T4999 1603-1611 GO:0016020 denotes membrane
T5000 1644-1654 PR_EXT:000004080 denotes annexin A7
T5001 1688-1700 GO:0006900 denotes vesiculation
T5002 1756-1768 GO:0006900 denotes vesiculation
T5003 1780-1783 CHEBI_EXT:GTP denotes GTP
T5004 1802-1812 PR_EXT:000004080 denotes annexin A7
T5005 1823-1829 GO_EXT:0003924 denotes GTPase
T5006 1858-1861 CHEBI_EXT:GTP denotes GTP
T5007 1875-1884 GO_EXT:secretion_entity_or_process denotes secretion
T5008 1888-1898 CHEBI_EXT:35195 denotes surfactant
T5009 1902-1912 PR_EXT:000004080 denotes annexin A7
T5010 1970-1980 PR_EXT:000004080 denotes annexin A7
T5011 1984-1994 CHEBI_EXT:35195 denotes surfactant
T5012 1995-2004 GO_EXT:secretion_entity_or_process denotes secretion
T5013 2027-2037 PR_EXT:000004080 denotes annexin A7
T5014 2047-2055 GO:0016020 denotes membrane
T5015 2047-2062 GO:0061025 denotes membrane fusion
T5016 2091-2094 CHEBI_EXT:GTP denotes GTP
T5017 2131-2141 PR_EXT:000004080 denotes annexin A7
T5018 2151-2156 NCBITaxon:10088 denotes mouse
T5019 2186-2196 PR_EXT:000004080 denotes annexin A7
T5020 2200-2210 _FRAGMENT denotes budding of
T5021 2226-2234 GO:0006900 denotes vesicles
T5022 2211-2225 CL:0000232 denotes red blood cell
T5023 2215-2220 UBERON:0000178 denotes blood
T5024 2221-2225 CL_GO_EXT:cell denotes cell
T5025 2226-2234 GO:0031982 denotes vesicles
T5026 2276-2282 _FRAGMENT denotes micro-
T5027 2291-2298 GO:1990742 denotes vesicle
T5028 2343-2352 SO_EXT:wild_type_entity_or_quality denotes wild type
T5029 2357-2363 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5030 2364-2379 CL:0000232 denotes red blood cells
T5031 2368-2373 UBERON:0000178 denotes blood
T5032 2374-2379 CL_GO_EXT:cell denotes cells
T5033 2391-2415 NCBITaxon:44689 denotes Dictyostelium discoideum
T5034 2416-2421 CL_GO_EXT:cell denotes cells
T5035 2451-2455 SO_EXT:0000704 denotes gene
T5036 2514-2522 GO:0016020 denotes membrane
T5037 2514-2529 GO:0061025 denotes membrane fusion
T5038 2605-2617 CHEBI:16247 denotes phospholipid
T5039 2628-2638 PR_EXT:000004080 denotes annexin A7
T5040 2663-2667 CHEBI:29108 denotes Ca2+
T5041 2755-2765 PR_EXT:000004080 denotes annexin A7
T5042 2769-2775 _FRAGMENT denotes micro-
T5043 2784-2792 GO:1990742 denotes vesicles
T5044 2848-2862 CL:0000232 denotes red blood cell
T5045 2852-2857 UBERON:0000178 denotes blood
T5046 2858-2871 GO:0005886 denotes cell membrane
T5047 2884-2894 PR_EXT:000004080 denotes annexin A7
T5048 2915-2919 CHEBI:29108 denotes Ca2+
T5049 2976-2987 GO:0070382 denotes exovesicles
T5050 3027-3037 PR_EXT:000004080 denotes annexin A7
T5051 3038-3046 SO_EXT:0001060 denotes isoforms
T5052 3063-3078 CL:0000232 denotes red blood cells
T5053 3067-3072 UBERON:0000178 denotes blood
T5054 3073-3078 CL_GO_EXT:cell denotes cells
T5055 3130-3141 GO_UBERON_EXT:cellular_component_or_cell_part denotes subcellular
T5056 3133-3141 CL_GO_EXT:cell denotes cellular
T5057 3142-3151 GO:0016020 denotes membranes
T5058 3155-3163 GO:0016020 denotes membrane
T5059 3182-3192 PR_EXT:000004075 denotes annexin A2
T5060 3220-3229 GO:0005768 denotes endosomes
T5061 3256-3264 GO:0016020 denotes membrane
T5062 3256-3271 GO:0061025 denotes membrane fusion
T5063 3280-3289 GO:0005768 denotes endosomal
T5064 3299-3309 PR_EXT:000004080 denotes annexin A7
T5065 3327-3355 GO:0044853 denotes plasma membrane raft domains
T5066 3408-3416 GO:0031982 denotes vesicles
T5067 3420-3435 CL:0000232 denotes red blood cells
T5068 3424-3429 UBERON:0000178 denotes blood
T5069 3430-3435 CL_GO_EXT:cell denotes cells
T5070 3444-3454 PR_EXT:000004080 denotes annexin A7
T5071 3469-3475 PR_EXT:000015619 denotes sorcin
T5072 3508-3520 GO_PATO_EXT:biological_localization_process_or_quality denotes localisation
T5073 3548-3558 PR_EXT:000004080 denotes annexin A7
T5074 3566-3576 GO:0010467 denotes expression
T5075 3584-3598 CL:0000232 denotes red blood cell
T5076 3584-3610 GO:0048821 denotes red blood cell development
T5077 3588-3593 UBERON:0000178 denotes blood
T5078 3594-3598 CL_GO_EXT:cell denotes cell
T5079 3657-3664 GO:0031982 denotes vesicle
T5080 3657-3674 GO:0006900 denotes vesicle formation
T5081 3679-3687 GO:0016020 denotes membrane
T5082 3679-3694 GO:0061025 denotes membrane fusion
T5083 3696-3706 PR_EXT:000004080 denotes annexin A7
T5084 3736-3740 CHEBI:29108 denotes Ca2+
T5085 3741-3748 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T5086 3749-3756 CHEBI_PR_EXT:protein denotes protein
T5087 3789-3799 PR_EXT:000004080 denotes annexin A7
T5088 3828-3836 GO:0016020 denotes membrane
T5089 3896-3906 PR_EXT:000004080 denotes annexin A7
T5090 3944-3948 CHEBI:29108 denotes Ca2+
T5091 3949-3960 GO:0042592 denotes homeostasis
T5092 3978-3986 GO:0016020 denotes membrane
T5093 4045-4069 SO_EXT:biological_conservation_process_or_quality denotes evolutionarily conserved
T5094 4070-4077 CHEBI_PR_EXT:protein denotes protein
T5095 4179-4186 PR_EXT:annexin denotes annexin
T5096 4220-4230 PR_EXT:000004080 denotes annexin A7
T5097 4255-4270 CL:0000232 denotes red blood cells
T5098 4259-4264 UBERON:0000178 denotes blood
T5099 4265-4270 CL_GO_EXT:cell denotes cells
T5100 4313-4328 CL:0000232 denotes red blood cells
T5101 4317-4322 UBERON:0000178 denotes blood
T5102 4323-4328 CL_GO_EXT:cell denotes cells
T5103 4359-4368 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T5104 4386-4401 GO:0005886 denotes plasma membrane
T5105 4410-4418 GO:0016020 denotes membrane
T5106 4430-4437 _FRAGMENT denotes part of
T5107 4442-4454 GO:0044430 denotes cytoskeleton
T5108 4490-4498 GO:0016020 denotes membrane
T5109 4499-4507 GO:0005856 denotes skeleton
T5110 4512-4520 GO_PR_EXT:spectrin denotes spectrin
T5111 4521-4530 GO_EXT:tetrameric_macromolecular_complex denotes tetramers
T5112 4556-4571 GO:0005884 denotes actin filaments
T5113 4590-4598 CHEBI_PR_EXT:protein denotes proteins
T5114 4619-4641 _FRAGMENT denotes cytoplasmic surface of
T5115 4656-4669 GO:0009898 denotes cell membrane
T5116 4646-4660 CL:0000232 denotes red blood cell
T5117 4650-4655 UBERON:0000178 denotes blood
T5118 4676-4684 GO:0016020 denotes Membrane
T5119 4685-4696 CHEBI:16113 denotes cholesterol
T5120 4708-4722 CL:0000232 denotes red blood cell
T5121 4712-4717 UBERON:0000178 denotes blood
T5122 4718-4722 CL_GO_EXT:cell denotes cell
T5123 4741-4759 GO:0005579 denotes complement complex
T5124 4782-4786 GO:0045121 denotes raft
T5125 4787-4798 CHEBI:16113 denotes cholesterol
T5126 4828-4832 GO:0045121 denotes raft
T5127 4833-4841 CHEBI_PR_EXT:protein denotes proteins
T5128 4897-4901 CL_GO_EXT:cell denotes cell
T5129 4897-4910 GO:0005886 denotes cell membrane
T5130 4938-4948 PR_EXT:000004080 denotes Annexin A7
T5139 5261-5276 GO:0005886 denotes plasma membrane
T5140 5350-5354 CHEBI:29108 denotes Ca2+
T5141 5359-5367 GO:0016020 denotes membrane
T5142 5368-5376 GO:0005856 denotes skeletal
T5143 5377-5385 CHEBI_PR_EXT:protein denotes proteins
T5144 5421-5435 CL:0000232 denotes red blood cell
T5145 5425-5430 UBERON:0000178 denotes blood
T5146 5431-5444 GO:0005886 denotes cell membrane
T5147 5471-5479 PR_EXT:annexin denotes Annexins
T5148 5502-5506 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T5149 5519-5526 GO:0031941 denotes F-actin
T5150 5574-5584 PR_EXT:000004080 denotes annexin A7
T5151 5673-5681 GO:0016020 denotes membrane
T5152 5682-5694 GO:0005856 denotes cytoskeleton
T5153 5696-5707 GO:0065007 denotes controlling
T5154 5708-5712 GO:0045121 denotes raft
T5155 5713-5720 CHEBI_PR_EXT:protein denotes protein
T5156 5753-5758 CHEBI:24870 denotes ionic
T5157 5771-5786 CL:0000232 denotes red blood cells
T5158 5775-5780 UBERON:0000178 denotes blood
T5159 5781-5786 CL_GO_EXT:cell denotes cells
T5160 5827-5845 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling pathways
T5161 5866-5876 PR_EXT:000004080 denotes annexin A7
T5162 5902-5913 GO:0005737 denotes cytoplasmic
T5163 5914-5918 CHEBI:29108 denotes Ca2+
T5164 5919-5930 GO:0042592 denotes homeostasis
T5165 5988-6001 GO:0005622 denotes intracellular
T5166 5993-6001 CL_GO_EXT:cell denotes cellular
T5167 6002-6006 CHEBI:29108 denotes Ca2+
T5168 6052-6060 GO:0016020 denotes membrane
T5169 6077-6085 GO:0065007 denotes regulate
T5170 6086-6100 CL:0000232 denotes red blood cell
T5171 6090-6095 UBERON:0000178 denotes blood
T5172 6096-6100 CL_GO_EXT:cell denotes cell
T5173 6141-6154 GO:0005622 denotes intracellular
T5174 6146-6154 CL_GO_EXT:cell denotes cellular
T5175 6155-6159 CHEBI:29108 denotes Ca2+
T5176 6173-6181 GO:0065007 denotes regulate
T5177 6186-6194 GO:0016020 denotes membrane
T5178 6213-6223 GO:0065007 denotes modulation
T5179 6227-6239 GO:0005856 denotes cytoskeletal
T5180 6240-6247 CHEBI_PR_EXT:protein denotes protein
T5181 6267-6271 CHEBI:29108 denotes Ca2+
T5182 6300-6312 CHEBI:16247 denotes phospholipid
T5183 6355-6370 CL:0000232 denotes red blood cells
T5184 6359-6364 UBERON:0000178 denotes blood
T5185 6365-6370 CL_GO_EXT:cell denotes cells
T5186 6390-6399 CHEBI:29108 denotes Ca2+ ions
T5187 6429-6437 GO:0016020 denotes membrane
T5188 6468-6480 GO:0005856 denotes cytoskeleton
T5189 6521-6529 CL:0000233 denotes platelet
T5190 6546-6556 PR_EXT:000004080 denotes annexin A7
T5191 6557-6563 SO_EXT:sequence_altered_entity denotes mutant
T5192 6572-6580 CL:0000233 denotes platelet
T5193 6572-6592 GO:0070527 denotes platelet aggregation
T5194 6679-6688 CL:0000233 denotes platelets
T5195 6697-6707 PR_EXT:000004080 denotes annexin A7
T5196 6792-6800 GO_EXT:reaction_or_response denotes reaction
T5197 6810-6816 NCBITaxon:39107 denotes murine
T5198 6817-6826 CL:0000233 denotes platelets
T5199 6856-6861 NCBITaxon:9606 denotes human
T5200 6936-6941 NCBITaxon:10088 denotes mouse
T5201 6965-6973 GO_EXT:reaction_or_response denotes reaction
T5202 6977-6982 NCBITaxon:10088 denotes mouse
T5203 6983-6992 CL:0000233 denotes platelets
T5204 7083-7091 CHEBI:9574 denotes thrombin
T5205 7136-7141 NCBITaxon:9606 denotes human
T5206 7142-7145 PR_EXT:000017364 denotes vWF
T5207 7164-7175 GO:0007599 denotes haemostatic
T5208 7249-7262 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T5209 7392-7400 CL:0000233 denotes platelet
T5210 7421-7429 CL:0000233 denotes platelet
T5211 7430-7437 CHEBI_EXT:59132 denotes antigen
T5212 7438-7450 SO_EXT:polymorphism denotes polymorphism
T5137 5146-5154 GO:0016020 denotes membrane
T5138 5210-5220 PR_EXT:000004080 denotes Annexin A7
T5131 4959-4964 NCBITaxon:10088 denotes mouse
T5132 4965-4980 CL:0000232 denotes red blood cells
T5133 4969-4974 UBERON:0000178 denotes blood
T5134 4975-4980 CL_GO_EXT:cell denotes cells
T5135 5058-5068 PR_EXT:000004080 denotes annexin A7
T5136 5083-5091 GO:0016020 denotes membrane
R2761 T5021 T5020 _lexicallyChainedTo vesicles,budding of
R2762 T5027 T5026 _lexicallyChainedTo vesicle,micro-
R2763 T5043 T5042 _lexicallyChainedTo vesicles,micro-
R2764 T5107 T5106 _lexicallyChainedTo cytoskeleton,part of
R2765 T5115 T5114 _lexicallyChainedTo cell membrane,cytoplasmic surface of
R2760 T4988 T4987 _lexicallyChainedTo membrane,leaflet of