PMC:194730 / 1832-7169 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1135	19-21	NN	denotes	A7
T1136	22-24	VBZ	denotes	is
T1137	25-26	DT	denotes	a
T1138	58-65	NN	denotes	protein
T1139	27-31	NN	denotes	Ca2+
T1140	50-57	VBG	denotes	binding
T1141	31-32	HYPH	denotes	-
T1142	33-36	CC	denotes	and
T1143	37-49	NN	denotes	phospholipid
T1144	49-50	HYPH	denotes	-
T1145	65-67	,	denotes	,
T1146	67-72	WDT	denotes	which
T1147	77-85	VBN	denotes	isolated
T1148	73-76	VBD	denotes	was
T1149	86-88	IN	denotes	as
T1150	89-92	DT	denotes	the
T1151	93-98	NN	denotes	agent
T1152	99-103	WDT	denotes	that
T1153	104-112	VBD	denotes	mediated
T1154	113-124	NN	denotes	aggregation
T1155	125-127	IN	denotes	of
T1156	128-138	NN	denotes	chromaffin
T1157	139-147	NNS	denotes	granules
T1158	148-151	CC	denotes	and
T1159	152-158	NN	denotes	fusion
T1160	159-161	IN	denotes	of
T1161	162-174	NN	denotes	phospholipid
T1162	175-184	NNS	denotes	membranes
T1163	185-187	IN	denotes	in
T1164	188-191	DT	denotes	the
T1165	192-200	NN	denotes	presence
T1166	201-203	IN	denotes	of
T1167	204-208	NN	denotes	Ca2+
T1168	208-209	.	denotes	.
T1169	209-322	sentence	denotes	This activity led to the proposal of annexin A7's involvement in the exocytotic secretion of catecholamines [1].
T1170	210-214	DT	denotes	This
T1171	215-223	NN	denotes	activity
T1172	224-227	VBD	denotes	led
T1173	228-230	IN	denotes	to
T1174	231-234	DT	denotes	the
T1175	235-243	NN	denotes	proposal
T1176	244-246	IN	denotes	of
T1177	247-254	NN	denotes	annexin
T1178	255-257	NN	denotes	A7
T1179	260-271	NN	denotes	involvement
T1180	257-259	POS	denotes	's
T1181	272-274	IN	denotes	in
T1182	275-278	DT	denotes	the
T1183	290-299	NN	denotes	secretion
T1184	279-289	JJ	denotes	exocytotic
T1185	300-302	IN	denotes	of
T1186	303-317	NNS	denotes	catecholamines
T1187	318-319	-LRB-	denotes	[
T1188	319-320	CD	denotes	1
T1189	320-321	-RRB-	denotes	]
T1190	321-322	.	denotes	.
T1191	322-478	sentence	denotes	The protein belongs to a family of evolutionarily conserved proteins of a bipartite structure with a variable N-terminal and a conserved C-terminal domain.
T1192	323-326	DT	denotes	The
T1193	327-334	NN	denotes	protein
T1194	335-342	VBZ	denotes	belongs
T1195	343-345	IN	denotes	to
T1196	346-347	DT	denotes	a
T1197	348-354	NN	denotes	family
T1198	355-357	IN	denotes	of
T1199	358-372	RB	denotes	evolutionarily
T1200	373-382	VBN	denotes	conserved
T1201	383-391	NN	denotes	proteins
T1202	392-394	IN	denotes	of
T1203	395-396	DT	denotes	a
T1204	407-416	NN	denotes	structure
T1205	397-406	JJ	denotes	bipartite
T1206	417-421	IN	denotes	with
T1207	422-423	DT	denotes	a
T1208	424-432	JJ	denotes	variable
T1209	433-434	NN	denotes	N
T1210	435-443	JJ	denotes	terminal
T1211	434-435	HYPH	denotes	-
T1212	444-447	CC	denotes	and
T1213	448-449	DT	denotes	a
T1214	450-459	VBN	denotes	conserved
T1215	460-461	NN	denotes	C
T1216	462-470	JJ	denotes	terminal
T1217	461-462	HYPH	denotes	-
T1218	471-477	NN	denotes	domain
T1219	477-478	.	denotes	.
T1220	478-623	sentence	denotes	The C-terminal domain is responsible for the Ca2+- and phospholipid-binding, the N-terminal domain appears to confer functional diversity [2-4].
T1221	479-482	DT	denotes	The
T1222	494-500	NN	denotes	domain
T1223	483-484	NN	denotes	C
T1224	485-493	JJ	denotes	terminal
T1225	484-485	HYPH	denotes	-
T1226	501-503	VBZ	denotes	is
T1227	578-585	VBZ	denotes	appears
T1228	504-515	JJ	denotes	responsible
T1229	516-519	IN	denotes	for
T1230	520-523	DT	denotes	the
T1231	524-528	NN	denotes	Ca2+
T1232	528-529	HYPH	denotes	-
T1233	530-533	CC	denotes	and
T1234	534-546	NN	denotes	phospholipid
T1235	546-547	HYPH	denotes	-
T1236	547-554	VBG	denotes	binding
T1237	554-556	,	denotes	,
T1238	556-559	DT	denotes	the
T1239	571-577	NN	denotes	domain
T1240	560-561	NN	denotes	N
T1241	562-570	JJ	denotes	terminal
T1242	561-562	HYPH	denotes	-
T1243	586-588	TO	denotes	to
T1244	589-595	VB	denotes	confer
T1245	596-606	JJ	denotes	functional
T1246	607-616	NN	denotes	diversity
T1247	617-618	-LRB-	denotes	[
T1248	618-619	CD	denotes	2
T1249	619-620	SYM	denotes	-
T1250	620-621	CD	denotes	4
T1251	621-622	-RRB-	denotes	]
T1252	622-623	.	denotes	.
T1253	623-711	sentence	denotes	The binding to negatively charged phospholipids is thought to be mediated by Ca2+ ions.
T1254	624-627	DT	denotes	The
T1255	628-635	NN	denotes	binding
T1256	675-682	VBN	denotes	thought
T1257	636-638	IN	denotes	to
T1258	639-649	RB	denotes	negatively
T1259	650-657	JJ	denotes	charged
T1260	658-671	NNS	denotes	phospholipids
T1261	672-674	VBZ	denotes	is
T1262	683-685	TO	denotes	to
T1263	689-697	VBN	denotes	mediated
T1264	686-688	VB	denotes	be
T1265	698-700	IN	denotes	by
T1266	701-705	NN	denotes	Ca2+
T1267	706-710	NNS	denotes	ions
T1268	710-711	.	denotes	.
T1269	711-838	sentence	denotes	Annexin A7 is unique in that it carries an extraordinarily long and hydrophobic amino terminus with more than 100 amino acids.
T1270	712-719	NN	denotes	Annexin
T1271	720-722	NN	denotes	A7
T1272	723-725	VBZ	denotes	is
T1273	726-732	JJ	denotes	unique
T1274	733-735	IN	denotes	in
T1275	744-751	VBZ	denotes	carries
T1276	736-740	IN	denotes	that
T1277	741-743	PRP	denotes	it
T1278	752-754	DT	denotes	an
T1279	798-806	NN	denotes	terminus
T1280	755-770	RB	denotes	extraordinarily
T1281	771-775	JJ	denotes	long
T1282	776-779	CC	denotes	and
T1283	780-791	JJ	denotes	hydrophobic
T1284	792-797	NN	denotes	amino
T1285	807-811	IN	denotes	with
T1286	812-816	JJR	denotes	more
T1287	822-825	CD	denotes	100
T1288	817-821	IN	denotes	than
T1289	832-837	NNS	denotes	acids
T1290	826-831	NN	denotes	amino
T1291	837-838	.	denotes	.
T1292	838-904	sentence	denotes	Alternative splicing gives rise to two isoforms of 47 and 51 kDa.
T1293	839-850	JJ	denotes	Alternative
T1294	851-859	NN	denotes	splicing
T1295	860-865	VBZ	denotes	gives
T1296	866-870	NN	denotes	rise
T1297	871-873	IN	denotes	to
T1298	874-877	CD	denotes	two
T1299	878-886	NNS	denotes	isoforms
T1300	887-889	IN	denotes	of
T1301	890-892	CD	denotes	47
T1302	900-903	NN	denotes	kDa
T1303	893-896	CC	denotes	and
T1304	897-899	CD	denotes	51
T1305	903-904	.	denotes	.
T1306	904-1009	sentence	denotes	Both isoforms differ by an additional cassette exon located in the first third of the N-terminal domain.
T1307	905-909	DT	denotes	Both
T1308	910-918	NNS	denotes	isoforms
T1309	919-925	VBP	denotes	differ
T1310	926-928	IN	denotes	by
T1311	929-931	DT	denotes	an
T1312	952-956	NN	denotes	exon
T1313	932-942	JJ	denotes	additional
T1314	943-951	NN	denotes	cassette
T1315	957-964	JJ	denotes	located
T1316	965-967	IN	denotes	in
T1317	968-971	DT	denotes	the
T1318	978-983	NN	denotes	third
T1319	972-977	JJ	denotes	first
T1320	984-986	IN	denotes	of
T1321	987-990	DT	denotes	the
T1322	1002-1008	NN	denotes	domain
T1323	991-992	NN	denotes	N
T1324	993-1001	JJ	denotes	terminal
T1325	992-993	HYPH	denotes	-
T1326	1008-1009	.	denotes	.
T1327	1009-1171	sentence	denotes	Most tissues harbor only the 47 kDa isoform, both forms are found in brain and heart, while the large isoform is exclusively expressed in mature skeletal muscle.
T1328	1010-1014	JJS	denotes	Most
T1329	1015-1022	NNS	denotes	tissues
T1330	1023-1029	VBP	denotes	harbor
T1331	1070-1075	VBN	denotes	found
T1332	1030-1034	RB	denotes	only
T1333	1046-1053	NN	denotes	isoform
T1334	1035-1038	DT	denotes	the
T1335	1039-1041	CD	denotes	47
T1336	1042-1045	NN	denotes	kDa
T1337	1053-1055	,	denotes	,
T1338	1055-1059	DT	denotes	both
T1339	1060-1065	NNS	denotes	forms
T1340	1066-1069	VBP	denotes	are
T1341	1076-1078	IN	denotes	in
T1342	1079-1084	NN	denotes	brain
T1343	1085-1088	CC	denotes	and
T1344	1089-1094	NN	denotes	heart
T1345	1094-1096	,	denotes	,
T1346	1096-1101	IN	denotes	while
T1347	1135-1144	VBN	denotes	expressed
T1348	1102-1105	DT	denotes	the
T1349	1112-1119	NN	denotes	isoform
T1350	1106-1111	JJ	denotes	large
T1351	1120-1122	VBZ	denotes	is
T1352	1123-1134	RB	denotes	exclusively
T1353	1145-1147	IN	denotes	in
T1354	1148-1154	JJ	denotes	mature
T1355	1164-1170	NN	denotes	muscle
T1356	1155-1163	JJ	denotes	skeletal
T1357	1170-1171	.	denotes	.
T1358	1171-1377	sentence	denotes	At the cellular level annexin A7 can be detected in the cytosol, at the plasma membrane, around the nucleus, at vesicular structures including adrenal chromaffin granules, and at the t-tubule system [5,6].
T1359	1172-1174	IN	denotes	At
T1360	1212-1220	VBN	denotes	detected
T1361	1175-1178	DT	denotes	the
T1362	1188-1193	NN	denotes	level
T1363	1179-1187	JJ	denotes	cellular
T1364	1194-1201	NN	denotes	annexin
T1365	1202-1204	NN	denotes	A7
T1366	1205-1208	MD	denotes	can
T1367	1209-1211	VB	denotes	be
T1368	1221-1223	IN	denotes	in
T1369	1224-1227	DT	denotes	the
T1370	1228-1235	NN	denotes	cytosol
T1371	1235-1237	,	denotes	,
T1372	1237-1239	IN	denotes	at
T1373	1240-1243	DT	denotes	the
T1374	1251-1259	NN	denotes	membrane
T1375	1244-1250	NN	denotes	plasma
T1376	1259-1261	,	denotes	,
T1377	1261-1267	IN	denotes	around
T1378	1268-1271	DT	denotes	the
T1379	1272-1279	NN	denotes	nucleus
T1380	1279-1281	,	denotes	,
T1381	1281-1283	IN	denotes	at
T1382	1284-1293	JJ	denotes	vesicular
T1383	1294-1304	NNS	denotes	structures
T1384	1305-1314	VBG	denotes	including
T1385	1315-1322	JJ	denotes	adrenal
T1386	1334-1342	NNS	denotes	granules
T1387	1323-1333	NN	denotes	chromaffin
T1388	1342-1344	,	denotes	,
T1389	1344-1347	CC	denotes	and
T1390	1348-1350	IN	denotes	at
T1391	1351-1354	DT	denotes	the
T1392	1364-1370	NN	denotes	system
T1393	1355-1356	NN	denotes	t
T1394	1357-1363	NN	denotes	tubule
T1395	1356-1357	HYPH	denotes	-
T1396	1371-1372	-LRB-	denotes	[
T1397	1374-1375	CD	denotes	6
T1398	1372-1373	CD	denotes	5
T1399	1373-1374	,	denotes	,
T1400	1375-1376	-RRB-	denotes	]
T1401	1376-1377	.	denotes	.
T1402	1377-1588	sentence	denotes	Annexin A7 translocates to membranes in a Ca2+-dependent fashion and, when intracellular Ca2+ levels rise, sequentially redistributes to the plasma and the nuclear membrane as well as to intracellular vesicles.
T1403	1378-1385	NN	denotes	Annexin
T1404	1386-1388	NN	denotes	A7
T1405	1389-1401	VBZ	denotes	translocates
T1406	1402-1404	IN	denotes	to
T1407	1405-1414	NNS	denotes	membranes
T1408	1415-1417	IN	denotes	in
T1409	1418-1419	DT	denotes	a
T1410	1435-1442	NN	denotes	fashion
T1411	1420-1424	NN	denotes	Ca2+
T1412	1425-1434	JJ	denotes	dependent
T1413	1424-1425	HYPH	denotes	-
T1414	1443-1446	CC	denotes	and
T1415	1446-1448	,	denotes	,
T1416	1498-1511	VBZ	denotes	redistributes
T1417	1448-1452	WRB	denotes	when
T1418	1479-1483	VBP	denotes	rise
T1419	1453-1466	JJ	denotes	intracellular
T1420	1472-1478	NNS	denotes	levels
T1421	1467-1471	NN	denotes	Ca2+
T1422	1483-1485	,	denotes	,
T1423	1485-1497	RB	denotes	sequentially
T1424	1512-1514	IN	denotes	to
T1425	1515-1518	DT	denotes	the
T1426	1519-1525	NN	denotes	plasma
T1427	1526-1529	CC	denotes	and
T1428	1530-1533	DT	denotes	the
T1429	1542-1550	NN	denotes	membrane
T1430	1534-1541	JJ	denotes	nuclear
T1431	1551-1553	RB	denotes	as
T1432	1559-1561	IN	denotes	as
T1433	1554-1558	RB	denotes	well
T1434	1562-1564	IN	denotes	to
T1435	1565-1578	JJ	denotes	intracellular
T1436	1579-1587	NNS	denotes	vesicles
T1437	1587-1588	.	denotes	.
T1438	1588-1645	sentence	denotes	Furthermore, annexin A7 associates with lipid rafts [7].
T1439	1589-1600	RB	denotes	Furthermore
T1440	1613-1623	VBZ	denotes	associates
T1441	1600-1602	,	denotes	,
T1442	1602-1609	NN	denotes	annexin
T1443	1610-1612	NN	denotes	A7
T1444	1624-1628	IN	denotes	with
T1445	1629-1634	NN	denotes	lipid
T1446	1635-1640	NNS	denotes	rafts
T1447	1641-1642	-LRB-	denotes	[
T1448	1642-1643	CD	denotes	7
T1449	1643-1644	-RRB-	denotes	]
T1450	1644-1645	.	denotes	.
T1451	1645-1760	sentence	denotes	Lipid rafts play a key role in membrane budding and in vesiculation processes such as endo- and exocytosis [8-10].
T1452	1646-1651	NN	denotes	Lipid
T1453	1652-1657	NNS	denotes	rafts
T1454	1658-1662	VBP	denotes	play
T1455	1663-1664	DT	denotes	a
T1456	1669-1673	NN	denotes	role
T1457	1665-1668	JJ	denotes	key
T1458	1674-1676	IN	denotes	in
T1459	1677-1685	NN	denotes	membrane
T1460	1686-1693	NN	denotes	budding
T1461	1694-1697	CC	denotes	and
T1462	1698-1700	IN	denotes	in
T1463	1701-1713	NN	denotes	vesiculation
T1464	1714-1723	NNS	denotes	processes
T1465	1724-1728	JJ	denotes	such
T1466	1729-1731	IN	denotes	as
T1467	1732-1736	AFX	denotes	endo
T1468	1742-1752	NN	denotes	exocytosis
T1469	1736-1737	HYPH	denotes	-
T1470	1738-1741	CC	denotes	and
T1471	1753-1754	-LRB-	denotes	[
T1472	1754-1755	CD	denotes	8
T1473	1755-1756	SYM	denotes	-
T1474	1756-1758	CD	denotes	10
T1475	1758-1759	-RRB-	denotes	]
T1476	1759-1760	.	denotes	.
T1477	1760-1848	sentence	denotes	Two binding partners of annexin A7 have been identified, sorcin and galectin-3 [11-13].
T1478	1761-1764	CD	denotes	Two
T1479	1773-1781	NNS	denotes	partners
T1480	1765-1772	VBG	denotes	binding
T1481	1806-1816	VBN	denotes	identified
T1482	1782-1784	IN	denotes	of
T1483	1785-1792	NN	denotes	annexin
T1484	1793-1795	NN	denotes	A7
T1485	1796-1800	VBP	denotes	have
T1486	1801-1805	VBN	denotes	been
T1487	1816-1818	,	denotes	,
T1488	1818-1824	NN	denotes	sorcin
T1489	1825-1828	CC	denotes	and
T1490	1829-1837	NN	denotes	galectin
T1491	1837-1838	HYPH	denotes	-
T1492	1838-1839	CD	denotes	3
T1493	1840-1841	-LRB-	denotes	[
T1494	1841-1843	CD	denotes	11
T1495	1843-1844	SYM	denotes	-
T1496	1844-1846	CD	denotes	13
T1497	1846-1847	-RRB-	denotes	]
T1498	1847-1848	.	denotes	.
T1499	1848-1935	sentence	denotes	Sorcin is a Ca2+-binding protein and belongs to the penta EF-hand protein family [14].
T1500	1849-1855	NN	denotes	Sorcin
T1501	1856-1858	VBZ	denotes	is
T1502	1859-1860	DT	denotes	a
T1503	1874-1881	NN	denotes	protein
T1504	1861-1865	NN	denotes	Ca2+
T1505	1866-1873	VBG	denotes	binding
T1506	1865-1866	HYPH	denotes	-
T1507	1882-1885	CC	denotes	and
T1508	1886-1893	VBZ	denotes	belongs
T1509	1894-1896	IN	denotes	to
T1510	1897-1900	DT	denotes	the
T1511	1923-1929	NN	denotes	family
T1512	1901-1906	NN	denotes	penta
T1513	1915-1922	NN	denotes	protein
T1514	1907-1909	NN	denotes	EF
T1515	1910-1914	NN	denotes	hand
T1516	1909-1910	HYPH	denotes	-
T1517	1930-1931	-LRB-	denotes	[
T1518	1931-1933	CD	denotes	14
T1519	1933-1934	-RRB-	denotes	]
T1520	1934-1935	.	denotes	.
T1521	1935-2001	sentence	denotes	Like annexin A7 it binds to membranes in a Ca2+-dependent manner.
T1522	1936-1940	IN	denotes	Like
T1523	1955-1960	VBZ	denotes	binds
T1524	1941-1948	NN	denotes	annexin
T1525	1949-1951	NN	denotes	A7
T1526	1952-1954	PRP	denotes	it
T1527	1961-1963	IN	denotes	to
T1528	1964-1973	NNS	denotes	membranes
T1529	1974-1976	IN	denotes	in
T1530	1977-1978	DT	denotes	a
T1531	1994-2000	NN	denotes	manner
T1532	1979-1983	NN	denotes	Ca2+
T1533	1984-1993	JJ	denotes	dependent
T1534	1983-1984	HYPH	denotes	-
T1535	2000-2001	.	denotes	.
T1536	2001-2125	sentence	denotes	Sorcin also has been described as interaction partner of the ryanodine receptor, and appears to modulate its function [15].
T1537	2002-2008	NN	denotes	Sorcin
T1538	2023-2032	VBN	denotes	described
T1539	2009-2013	RB	denotes	also
T1540	2014-2017	VBZ	denotes	has
T1541	2018-2022	VBN	denotes	been
T1542	2033-2035	IN	denotes	as
T1543	2036-2047	NN	denotes	interaction
T1544	2048-2055	NN	denotes	partner
T1545	2056-2058	IN	denotes	of
T1546	2059-2062	DT	denotes	the
T1547	2073-2081	NN	denotes	receptor
T1548	2063-2072	NN	denotes	ryanodine
T1549	2081-2083	,	denotes	,
T1550	2083-2086	CC	denotes	and
T1551	2087-2094	VBZ	denotes	appears
T1552	2095-2097	TO	denotes	to
T1553	2098-2106	VB	denotes	modulate
T1554	2107-2110	PRP$	denotes	its
T1555	2111-2119	NN	denotes	function
T1556	2120-2121	-LRB-	denotes	[
T1557	2121-2123	CD	denotes	15
T1558	2123-2124	-RRB-	denotes	]
T1559	2124-2125	.	denotes	.
T1560	2125-2214	sentence	denotes	The influence of the sorcin/annexin A7 interaction on the ryanodine receptor is unknown.
T1561	2126-2129	DT	denotes	The
T1562	2130-2139	NN	denotes	influence
T1563	2203-2205	VBZ	denotes	is
T1564	2140-2142	IN	denotes	of
T1565	2143-2146	DT	denotes	the
T1566	2165-2176	NN	denotes	interaction
T1567	2147-2153	NN	denotes	sorcin
T1568	2154-2161	NN	denotes	annexin
T1569	2153-2154	HYPH	denotes	/
T1570	2162-2164	NN	denotes	A7
T1571	2177-2179	IN	denotes	on
T1572	2180-2183	DT	denotes	the
T1573	2194-2202	NN	denotes	receptor
T1574	2184-2193	NN	denotes	ryanodine
T1575	2206-2213	JJ	denotes	unknown
T1576	2213-2214	.	denotes	.
T1577	2214-2289	sentence	denotes	Sorcin and annexin A7 are coexpressed in all tissues examined so far [11].
T1578	2215-2221	NN	denotes	Sorcin
T1579	2241-2252	VBN	denotes	coexpressed
T1580	2222-2225	CC	denotes	and
T1581	2226-2233	NN	denotes	annexin
T1582	2234-2236	NN	denotes	A7
T1583	2237-2240	VBP	denotes	are
T1584	2253-2255	IN	denotes	in
T1585	2256-2259	DT	denotes	all
T1586	2260-2267	NNS	denotes	tissues
T1587	2268-2276	VBN	denotes	examined
T1588	2277-2279	RB	denotes	so
T1589	2280-2283	RB	denotes	far
T1590	2284-2285	-LRB-	denotes	[
T1591	2285-2287	CD	denotes	11
T1592	2287-2288	-RRB-	denotes	]
T1593	2288-2289	.	denotes	.
T1594	2289-2390	sentence	denotes	The binding of annexin A7 and sorcin is Ca2+-dependent and occurs at micromolar Ca2+ concentrations.
T1595	2290-2293	DT	denotes	The
T1596	2294-2301	NN	denotes	binding
T1597	2327-2329	VBZ	denotes	is
T1598	2302-2304	IN	denotes	of
T1599	2305-2312	NN	denotes	annexin
T1600	2313-2315	NN	denotes	A7
T1601	2316-2319	CC	denotes	and
T1602	2320-2326	NN	denotes	sorcin
T1603	2330-2334	NN	denotes	Ca2+
T1604	2335-2344	JJ	denotes	dependent
T1605	2334-2335	HYPH	denotes	-
T1606	2345-2348	CC	denotes	and
T1607	2349-2355	VBZ	denotes	occurs
T1608	2356-2358	IN	denotes	at
T1609	2359-2369	JJ	denotes	micromolar
T1610	2370-2374	NN	denotes	Ca2+
T1611	2375-2389	NNS	denotes	concentrations
T1612	2389-2390	.	denotes	.
T1613	2390-2540	sentence	denotes	The binding sites have been localised to the amino terminal GGYY and GYGG motifs in sorcin and to the GYPP motif in the amino terminus of annexin A7.
T1614	2391-2394	DT	denotes	The
T1615	2403-2408	NNS	denotes	sites
T1616	2395-2402	VBG	denotes	binding
T1617	2419-2428	VBN	denotes	localised
T1618	2409-2413	VBP	denotes	have
T1619	2414-2418	VBN	denotes	been
T1620	2429-2431	IN	denotes	to
T1621	2432-2435	DT	denotes	the
T1622	2465-2471	NNS	denotes	motifs
T1623	2436-2441	NN	denotes	amino
T1624	2442-2450	JJ	denotes	terminal
T1625	2451-2455	NN	denotes	GGYY
T1626	2456-2459	CC	denotes	and
T1627	2460-2464	NN	denotes	GYGG
T1628	2472-2474	IN	denotes	in
T1629	2475-2481	NN	denotes	sorcin
T1630	2482-2485	CC	denotes	and
T1631	2486-2488	IN	denotes	to
T1632	2489-2492	DT	denotes	the
T1633	2498-2503	NN	denotes	motif
T1634	2493-2497	NN	denotes	GYPP
T1635	2504-2506	IN	denotes	in
T1636	2507-2510	DT	denotes	the
T1637	2517-2525	NN	denotes	terminus
T1638	2511-2516	NN	denotes	amino
T1639	2526-2528	IN	denotes	of
T1640	2529-2536	NN	denotes	annexin
T1641	2537-2539	NN	denotes	A7
T1642	2539-2540	.	denotes	.
T1643	2540-2647	sentence	denotes	The proteins bind to each other with a stoichiometry of two sorcin molecules per annexin A7 molecule [12].
T1644	2541-2544	DT	denotes	The
T1645	2545-2553	NN	denotes	proteins
T1646	2554-2558	VBP	denotes	bind
T1647	2559-2561	IN	denotes	to
T1648	2562-2566	DT	denotes	each
T1649	2567-2572	JJ	denotes	other
T1650	2573-2577	IN	denotes	with
T1651	2578-2579	DT	denotes	a
T1652	2580-2593	NN	denotes	stoichiometry
T1653	2594-2596	IN	denotes	of
T1654	2597-2600	CD	denotes	two
T1655	2608-2617	NNS	denotes	molecules
T1656	2601-2607	NN	denotes	sorcin
T1657	2618-2621	IN	denotes	per
T1658	2622-2629	NN	denotes	annexin
T1659	2630-2632	NN	denotes	A7
T1660	2633-2641	NN	denotes	molecule
T1661	2642-2643	-LRB-	denotes	[
T1662	2643-2645	CD	denotes	12
T1663	2645-2646	-RRB-	denotes	]
T1664	2646-2647	.	denotes	.
T1665	2647-2813	sentence	denotes	Galectin-3 is a multifunctional oncogenic protein with an anti-apoptotic activity found in the extracellular space, in the nucleus and cytoplasm and in mitochondria.
T1666	2648-2656	NN	denotes	Galectin
T1667	2659-2661	VBZ	denotes	is
T1668	2656-2657	HYPH	denotes	-
T1669	2657-2658	CD	denotes	3
T1670	2662-2663	DT	denotes	a
T1671	2690-2697	NN	denotes	protein
T1672	2664-2679	JJ	denotes	multifunctional
T1673	2680-2689	JJ	denotes	oncogenic
T1674	2698-2702	IN	denotes	with
T1675	2703-2705	DT	denotes	an
T1676	2721-2729	NN	denotes	activity
T1677	2706-2720	JJ	denotes	anti-apoptotic
T1678	2730-2735	VBN	denotes	found
T1679	2736-2738	IN	denotes	in
T1680	2739-2742	DT	denotes	the
T1681	2757-2762	NN	denotes	space
T1682	2743-2756	JJ	denotes	extracellular
T1683	2762-2764	,	denotes	,
T1684	2764-2766	IN	denotes	in
T1685	2767-2770	DT	denotes	the
T1686	2771-2778	NN	denotes	nucleus
T1687	2779-2782	CC	denotes	and
T1688	2783-2792	NN	denotes	cytoplasm
T1689	2793-2796	CC	denotes	and
T1690	2797-2799	IN	denotes	in
T1691	2800-2812	NNS	denotes	mitochondria
T1692	2812-2813	.	denotes	.
T1693	2813-2908	sentence	denotes	Cytoplasmic galectin-3 correlates with tumor progression and protects mitochondrial integrity.
T1694	2814-2825	JJ	denotes	Cytoplasmic
T1695	2826-2834	NN	denotes	galectin
T1696	2837-2847	VBZ	denotes	correlates
T1697	2834-2835	HYPH	denotes	-
T1698	2835-2836	CD	denotes	3
T1699	2848-2852	IN	denotes	with
T1700	2853-2858	NN	denotes	tumor
T1701	2859-2870	NN	denotes	progression
T1702	2871-2874	CC	denotes	and
T1703	2875-2883	VBZ	denotes	protects
T1704	2884-2897	JJ	denotes	mitochondrial
T1705	2898-2907	NN	denotes	integrity
T1706	2907-2908	.	denotes	.
T1707	2908-3036	sentence	denotes	Down regulation of annexin A7 prevents galectin-3 translocation to the perinuclear membrane and increases galectin-3 secretion.
T1708	2909-2913	NN	denotes	Down
T1709	2914-2924	NN	denotes	regulation
T1710	2939-2947	VBZ	denotes	prevents
T1711	2925-2927	IN	denotes	of
T1712	2928-2935	NN	denotes	annexin
T1713	2936-2938	NN	denotes	A7
T1714	2948-2956	NN	denotes	galectin
T1715	2957-2958	NN	denotes	3
T1716	2956-2957	HYPH	denotes	-
T1717	2959-2972	NN	denotes	translocation
T1718	2973-2975	IN	denotes	to
T1719	2976-2979	DT	denotes	the
T1720	2992-3000	NN	denotes	membrane
T1721	2980-2991	JJ	denotes	perinuclear
T1722	3001-3004	CC	denotes	and
T1723	3005-3014	VBZ	denotes	increases
T1724	3015-3023	NN	denotes	galectin
T1725	3024-3025	NN	denotes	3
T1726	3023-3024	HYPH	denotes	-
T1727	3026-3035	NN	denotes	secretion
T1728	3035-3036	.	denotes	.
T1729	3036-3155	sentence	denotes	For annexin A7 a role for galectin-3 trafficking, apoptosis regulation, and mitochondrial integrity was proposed [13].
T1730	3037-3040	IN	denotes	For
T1731	3141-3149	VBN	denotes	proposed
T1732	3041-3048	NN	denotes	annexin
T1733	3049-3051	NN	denotes	A7
T1734	3052-3053	DT	denotes	a
T1735	3054-3058	NN	denotes	role
T1736	3059-3062	IN	denotes	for
T1737	3063-3071	NN	denotes	galectin
T1738	3072-3073	NN	denotes	3
T1739	3071-3072	HYPH	denotes	-
T1740	3074-3085	NN	denotes	trafficking
T1741	3085-3087	,	denotes	,
T1742	3087-3096	NN	denotes	apoptosis
T1743	3097-3107	NN	denotes	regulation
T1744	3107-3109	,	denotes	,
T1745	3109-3112	CC	denotes	and
T1746	3113-3126	JJ	denotes	mitochondrial
T1747	3127-3136	NN	denotes	integrity
T1748	3137-3140	VBD	denotes	was
T1749	3150-3151	-LRB-	denotes	[
T1750	3151-3153	CD	denotes	13
T1751	3153-3154	-RRB-	denotes	]
T1752	3154-3155	.	denotes	.
T1753	3155-3211	sentence	denotes	The cellular role of annexin A7 is not well understood.
T1754	3156-3159	DT	denotes	The
T1755	3169-3173	NN	denotes	role
T1756	3160-3168	JJ	denotes	cellular
T1757	3200-3210	VBN	denotes	understood
T1758	3174-3176	IN	denotes	of
T1759	3177-3184	NN	denotes	annexin
T1760	3185-3187	NN	denotes	A7
T1761	3188-3190	VBZ	denotes	is
T1762	3191-3194	RB	denotes	not
T1763	3195-3199	RB	denotes	well
T1764	3210-3211	.	denotes	.
T1765	3211-3346	sentence	denotes	It is thought to regulate and stabilize membrane domains and to have a role in Ca2+ homeostasis and Ca2+-dependent signaling pathways.
T1766	3212-3214	PRP	denotes	It
T1767	3218-3225	VBN	denotes	thought
T1768	3215-3217	VBZ	denotes	is
T1769	3226-3228	TO	denotes	to
T1770	3229-3237	VB	denotes	regulate
T1771	3238-3241	CC	denotes	and
T1772	3242-3251	VB	denotes	stabilize
T1773	3252-3260	NN	denotes	membrane
T1774	3261-3268	NNS	denotes	domains
T1775	3269-3272	CC	denotes	and
T1776	3273-3275	TO	denotes	to
T1777	3276-3280	VB	denotes	have
T1778	3281-3282	DT	denotes	a
T1779	3283-3287	NN	denotes	role
T1780	3288-3290	IN	denotes	in
T1781	3291-3295	NN	denotes	Ca2+
T1782	3296-3307	NN	denotes	homeostasis
T1783	3308-3311	CC	denotes	and
T1784	3312-3316	NN	denotes	Ca2+
T1785	3317-3326	JJ	denotes	dependent
T1786	3316-3317	HYPH	denotes	-
T1787	3337-3345	NNS	denotes	pathways
T1788	3327-3336	NN	denotes	signaling
T1789	3345-3346	.	denotes	.
T1790	3346-3446	sentence	denotes	These proposals are supported by data obtained from analysis of annexin A7 deficient mouse mutants.
T1791	3347-3352	DT	denotes	These
T1792	3353-3362	NNS	denotes	proposals
T1793	3367-3376	VBN	denotes	supported
T1794	3363-3366	VBP	denotes	are
T1795	3377-3379	IN	denotes	by
T1796	3380-3384	NNS	denotes	data
T1797	3385-3393	VBN	denotes	obtained
T1798	3394-3398	IN	denotes	from
T1799	3399-3407	NN	denotes	analysis
T1800	3408-3410	IN	denotes	of
T1801	3411-3418	NN	denotes	annexin
T1802	3419-3421	NN	denotes	A7
T1803	3422-3431	JJ	denotes	deficient
T1804	3438-3445	NNS	denotes	mutants
T1805	3432-3437	NN	denotes	mouse
T1806	3445-3446	.	denotes	.
T1807	3446-3542	sentence	denotes	Two annexin A7 129Sv null mice strains were generated independently using a different strategy.
T1808	3447-3450	CD	denotes	Two
T1809	3478-3485	NNS	denotes	strains
T1810	3451-3458	NN	denotes	annexin
T1811	3459-3461	NN	denotes	A7
T1812	3462-3467	NN	denotes	129Sv
T1813	3468-3472	JJ	denotes	null
T1814	3473-3477	NNS	denotes	mice
T1815	3491-3500	VBN	denotes	generated
T1816	3486-3490	VBD	denotes	were
T1817	3501-3514	RB	denotes	independently
T1818	3515-3520	VBG	denotes	using
T1819	3521-3522	DT	denotes	a
T1820	3533-3541	NN	denotes	strategy
T1821	3523-3532	JJ	denotes	different
T1822	3541-3542	.	denotes	.
T1823	3542-3587	sentence	denotes	The one of Srivastava et al. [16] is lethal.
T1824	3543-3546	DT	denotes	The
T1825	3547-3550	CD	denotes	one
T1826	3577-3579	VBZ	denotes	is
T1827	3551-3553	IN	denotes	of
T1828	3554-3564	NNP	denotes	Srivastava
T1829	3565-3567	FW	denotes	et
T1830	3568-3571	FW	denotes	al.
T1831	3572-3573	-LRB-	denotes	[
T1832	3573-3575	CD	denotes	16
T1833	3575-3576	-RRB-	denotes	]
T1834	3580-3586	JJ	denotes	lethal
T1835	3586-3587	.	denotes	.
T1836	3587-3663	sentence	denotes	Heterozygous mice exhibit an insulin secretion defect and tumor phenotypes.
T1837	3588-3600	JJ	denotes	Heterozygous
T1838	3601-3605	NNS	denotes	mice
T1839	3606-3613	VBP	denotes	exhibit
T1840	3614-3616	DT	denotes	an
T1841	3635-3641	NN	denotes	defect
T1842	3617-3624	NN	denotes	insulin
T1843	3625-3634	NN	denotes	secretion
T1844	3642-3645	CC	denotes	and
T1845	3646-3651	NN	denotes	tumor
T1846	3652-3662	NNS	denotes	phenotypes
T1847	3662-3663	.	denotes	.
T1848	3663-3792	sentence	denotes	The null strain reported by Herr et al. [17] is viable, healthy, and shows no insulin secretion defect or other obvious defects.
T1849	3664-3667	DT	denotes	The
T1850	3673-3679	NN	denotes	strain
T1851	3668-3672	JJ	denotes	null
T1852	3709-3711	VBZ	denotes	is
T1853	3680-3688	VBN	denotes	reported
T1854	3689-3691	IN	denotes	by
T1855	3692-3696	NNP	denotes	Herr
T1856	3697-3699	FW	denotes	et
T1857	3700-3703	FW	denotes	al.
T1858	3704-3705	-LRB-	denotes	[
T1859	3705-3707	CD	denotes	17
T1860	3707-3708	-RRB-	denotes	]
T1861	3712-3718	JJ	denotes	viable
T1862	3720-3727	JJ	denotes	healthy
T1863	3718-3720	,	denotes	,
T1864	3727-3729	,	denotes	,
T1865	3729-3732	CC	denotes	and
T1866	3733-3738	VBZ	denotes	shows
T1867	3739-3741	DT	denotes	no
T1868	3760-3766	NN	denotes	defect
T1869	3742-3749	NN	denotes	insulin
T1870	3750-3759	NN	denotes	secretion
T1871	3767-3769	CC	denotes	or
T1872	3770-3775	JJ	denotes	other
T1873	3784-3791	NNS	denotes	defects
T1874	3776-3783	JJ	denotes	obvious
T1875	3791-3792	.	denotes	.
T1876	3792-3875	sentence	denotes	However, in isolated cardiomyocytes the frequency-induced shortening is disturbed.
T1877	3793-3800	RB	denotes	However
T1878	3865-3874	VBN	denotes	disturbed
T1879	3800-3802	,	denotes	,
T1880	3802-3804	IN	denotes	in
T1881	3805-3813	VBN	denotes	isolated
T1882	3814-3828	NNS	denotes	cardiomyocytes
T1883	3829-3832	DT	denotes	the
T1884	3851-3861	NN	denotes	shortening
T1885	3833-3842	NN	denotes	frequency
T1886	3843-3850	VBN	denotes	induced
T1887	3842-3843	HYPH	denotes	-
T1888	3862-3864	VBZ	denotes	is
T1889	3874-3875	.	denotes	.
T1890	3875-3969	sentence	denotes	Here we have focused on the analysis of red blood cells and platelets of the anxA7-/- mutant.
T1891	3876-3880	RB	denotes	Here
T1892	3889-3896	VBN	denotes	focused
T1893	3881-3883	PRP	denotes	we
T1894	3884-3888	VBP	denotes	have
T1895	3897-3899	IN	denotes	on
T1896	3900-3903	DT	denotes	the
T1897	3904-3912	NN	denotes	analysis
T1898	3913-3915	IN	denotes	of
T1899	3916-3919	JJ	denotes	red
T1900	3926-3931	NNS	denotes	cells
T1901	3920-3925	NN	denotes	blood
T1902	3932-3935	CC	denotes	and
T1903	3936-3945	NNS	denotes	platelets
T1904	3946-3948	IN	denotes	of
T1905	3949-3952	DT	denotes	the
T1906	3962-3968	NN	denotes	mutant
T1907	3953-3958	JJ	denotes	anxA7
T1908	3958-3959	SYM	denotes	-
T1909	3959-3960	HYPH	denotes	/
T1910	3960-3961	SYM	denotes	-
T1911	3968-3969	.	denotes	.
T1912	3969-4141	sentence	denotes	Generally, red blood cells and platelets were thought not to contain annexin A7 and only recently the 47 kDa isoform has been reported as component of red blood cells [7].
T1913	3970-3979	RB	denotes	Generally
T1914	4016-4023	VBN	denotes	thought
T1915	3979-3981	,	denotes	,
T1916	3981-3984	JJ	denotes	red
T1917	3991-3996	NNS	denotes	cells
T1918	3985-3990	NN	denotes	blood
T1919	3997-4000	CC	denotes	and
T1920	4001-4010	NNS	denotes	platelets
T1921	4011-4015	VBD	denotes	were
T1922	4024-4027	RB	denotes	not
T1923	4028-4030	TO	denotes	to
T1924	4031-4038	VB	denotes	contain
T1925	4039-4046	NN	denotes	annexin
T1926	4047-4049	NN	denotes	A7
T1927	4050-4053	CC	denotes	and
T1928	4054-4058	RB	denotes	only
T1929	4059-4067	RB	denotes	recently
T1930	4096-4104	VBN	denotes	reported
T1931	4068-4071	DT	denotes	the
T1932	4079-4086	NN	denotes	isoform
T1933	4072-4074	CD	denotes	47
T1934	4075-4078	NN	denotes	kDa
T1935	4087-4090	VBZ	denotes	has
T1936	4091-4095	VBN	denotes	been
T1937	4105-4107	IN	denotes	as
T1938	4108-4117	NN	denotes	component
T1939	4118-4120	IN	denotes	of
T1940	4121-4124	JJ	denotes	red
T1941	4131-4136	NNS	denotes	cells
T1942	4125-4130	NN	denotes	blood
T1943	4137-4138	-LRB-	denotes	[
T1944	4138-4139	CD	denotes	7
T1945	4139-4140	-RRB-	denotes	]
T1946	4140-4141	.	denotes	.
T1947	4141-4262	sentence	denotes	Red blood cells undergo various biochemical or morphological changes that appear to be Ca2+-dependent processes [18,19].
T1948	4142-4145	JJ	denotes	Red
T1949	4152-4157	NNS	denotes	cells
T1950	4146-4151	NN	denotes	blood
T1951	4158-4165	VBP	denotes	undergo
T1952	4166-4173	JJ	denotes	various
T1953	4203-4210	NNS	denotes	changes
T1954	4174-4185	JJ	denotes	biochemical
T1955	4186-4188	CC	denotes	or
T1956	4189-4202	JJ	denotes	morphological
T1957	4211-4215	WDT	denotes	that
T1958	4216-4222	VBP	denotes	appear
T1959	4223-4225	TO	denotes	to
T1960	4226-4228	VB	denotes	be
T1961	4229-4233	NN	denotes	Ca2+
T1962	4234-4243	JJ	denotes	dependent
T1963	4233-4234	HYPH	denotes	-
T1964	4244-4253	NNS	denotes	processes
T1965	4254-4255	-LRB-	denotes	[
T1966	4258-4260	CD	denotes	19
T1967	4255-4257	CD	denotes	18
T1968	4257-4258	,	denotes	,
T1969	4260-4261	-RRB-	denotes	]
T1970	4261-4262	.	denotes	.
T1971	4262-4372	sentence	denotes	One of them is the release of hemoglobin-containing exovesicles occurring in vivo as well as in vitro [7,20].
T1972	4263-4266	CD	denotes	One
T1973	4275-4277	VBZ	denotes	is
T1974	4267-4269	IN	denotes	of
T1975	4270-4274	PRP	denotes	them
T1976	4278-4281	DT	denotes	the
T1977	4282-4289	NN	denotes	release
T1978	4290-4292	IN	denotes	of
T1979	4293-4303	NN	denotes	hemoglobin
T1980	4304-4314	VBG	denotes	containing
T1981	4303-4304	HYPH	denotes	-
T1982	4315-4326	NNS	denotes	exovesicles
T1983	4327-4336	VBG	denotes	occurring
T1984	4337-4339	FW	denotes	in
T1985	4340-4344	FW	denotes	vivo
T1986	4345-4347	RB	denotes	as
T1987	4353-4355	IN	denotes	as
T1988	4348-4352	RB	denotes	well
T1989	4356-4358	FW	denotes	in
T1990	4359-4364	FW	denotes	vitro
T1991	4365-4366	-LRB-	denotes	[
T1992	4368-4370	CD	denotes	20
T1993	4366-4367	CD	denotes	7
T1994	4367-4368	,	denotes	,
T1995	4370-4371	-RRB-	denotes	]
T1996	4371-4372	.	denotes	.
T1997	4372-4507	sentence	denotes	This process is thought to represent a protective method of the red blood cell against an attack by for example complement components.
T1998	4373-4377	DT	denotes	This
T1999	4378-4385	NN	denotes	process
T2000	4389-4396	VBN	denotes	thought
T2001	4386-4388	VBZ	denotes	is
T2002	4397-4399	TO	denotes	to
T2003	4400-4409	VB	denotes	represent
T2004	4410-4411	DT	denotes	a
T2005	4423-4429	NN	denotes	method
T2006	4412-4422	JJ	denotes	protective
T2007	4430-4432	IN	denotes	of
T2008	4433-4436	DT	denotes	the
T2009	4447-4451	NN	denotes	cell
T2010	4437-4440	JJ	denotes	red
T2011	4441-4446	NN	denotes	blood
T2012	4452-4459	IN	denotes	against
T2013	4460-4462	DT	denotes	an
T2014	4463-4469	NN	denotes	attack
T2015	4470-4472	IN	denotes	by
T2016	4473-4476	IN	denotes	for
T2017	4496-4506	NNS	denotes	components
T2018	4477-4484	NN	denotes	example
T2019	4485-4495	NN	denotes	complement
T2020	4506-4507	.	denotes	.
T2021	4507-4634	sentence	denotes	Red blood cells which lack the ability to vesiculate cause a disease with red blood cell destruction and haemoglobinuria [21].
T2022	4508-4511	JJ	denotes	Red
T2023	4518-4523	NNS	denotes	cells
T2024	4512-4517	NN	denotes	blood
T2025	4561-4566	VB	denotes	cause
T2026	4524-4529	WDT	denotes	which
T2027	4530-4534	VBP	denotes	lack
T2028	4535-4538	DT	denotes	the
T2029	4539-4546	NN	denotes	ability
T2030	4547-4549	TO	denotes	to
T2031	4550-4560	VB	denotes	vesiculate
T2032	4567-4568	DT	denotes	a
T2033	4569-4576	NN	denotes	disease
T2034	4577-4581	IN	denotes	with
T2035	4582-4585	JJ	denotes	red
T2036	4592-4596	NN	denotes	cell
T2037	4586-4591	NN	denotes	blood
T2038	4597-4608	NN	denotes	destruction
T2039	4609-4612	CC	denotes	and
T2040	4613-4628	NN	denotes	haemoglobinuria
T2041	4629-4630	-LRB-	denotes	[
T2042	4630-4632	CD	denotes	21
T2043	4632-4633	-RRB-	denotes	]
T2044	4633-4634	.	denotes	.
T2045	4634-4740	sentence	denotes	There exist two types of vesicles, micro- and nanovesicles with a size of 180 nm and 60 nm, respectively.
T2046	4635-4640	EX	denotes	There
T2047	4641-4646	VBP	denotes	exist
T2048	4647-4650	CD	denotes	two
T2049	4651-4656	NNS	denotes	types
T2050	4657-4659	IN	denotes	of
T2051	4660-4668	NNS	denotes	vesicles
T2052	4668-4670	,	denotes	,
T2053	4670-4675	AFX	denotes	micro
T2054	4681-4693	NNS	denotes	nanovesicles
T2055	4675-4676	HYPH	denotes	-
T2056	4677-4680	CC	denotes	and
T2057	4694-4698	IN	denotes	with
T2058	4699-4700	DT	denotes	a
T2059	4701-4705	NN	denotes	size
T2060	4706-4708	IN	denotes	of
T2061	4709-4712	CD	denotes	180
T2062	4713-4715	NN	denotes	nm
T2063	4716-4719	CC	denotes	and
T2064	4720-4722	CD	denotes	60
T2065	4723-4725	NN	denotes	nm
T2066	4725-4727	,	denotes	,
T2067	4727-4739	RB	denotes	respectively
T2068	4739-4740	.	denotes	.
T2069	4740-5026	sentence	denotes	They are enriched in cholesterol and sphingolipid rich lipid raft domains that are associated with proteins like acetylcholinesterase, cell surface proteins including a complement receptor, and the lipid raft proteins stomatin and flotillin, but they lack any cytoskeletal protein [7].
T2070	4741-4745	PRP	denotes	They
T2071	4750-4758	VBN	denotes	enriched
T2072	4746-4749	VBP	denotes	are
T2073	4759-4761	IN	denotes	in
T2074	4762-4773	NN	denotes	cholesterol
T2075	4791-4795	JJ	denotes	rich
T2076	4774-4777	CC	denotes	and
T2077	4778-4790	NN	denotes	sphingolipid
T2078	4807-4814	NNS	denotes	domains
T2079	4796-4801	NN	denotes	lipid
T2080	4802-4806	NN	denotes	raft
T2081	4815-4819	WDT	denotes	that
T2082	4824-4834	VBN	denotes	associated
T2083	4820-4823	VBP	denotes	are
T2084	4835-4839	IN	denotes	with
T2085	4840-4848	NN	denotes	proteins
T2086	4849-4853	IN	denotes	like
T2087	4854-4874	NN	denotes	acetylcholinesterase
T2088	4874-4876	,	denotes	,
T2089	4876-4880	NN	denotes	cell
T2090	4889-4897	NN	denotes	proteins
T2091	4881-4888	NN	denotes	surface
T2092	4898-4907	VBG	denotes	including
T2093	4908-4909	DT	denotes	a
T2094	4921-4929	NN	denotes	receptor
T2095	4910-4920	NN	denotes	complement
T2096	4929-4931	,	denotes	,
T2097	4931-4934	CC	denotes	and
T2098	4935-4938	DT	denotes	the
T2099	4950-4958	NN	denotes	proteins
T2100	4939-4944	NN	denotes	lipid
T2101	4945-4949	NN	denotes	raft
T2102	4959-4967	NN	denotes	stomatin
T2103	4968-4971	CC	denotes	and
T2104	4972-4981	NN	denotes	flotillin
T2105	4981-4983	,	denotes	,
T2106	4983-4986	CC	denotes	but
T2107	4987-4991	PRP	denotes	they
T2108	4992-4996	VBP	denotes	lack
T2109	4997-5000	DT	denotes	any
T2110	5014-5021	NN	denotes	protein
T2111	5001-5013	JJ	denotes	cytoskeletal
T2112	5022-5023	-LRB-	denotes	[
T2113	5023-5024	CD	denotes	7
T2114	5024-5025	-RRB-	denotes	]
T2115	5025-5026	.	denotes	.
T2116	5026-5103	sentence	denotes	Furthermore, they contain sorcin and annexin A7 attached to the lipid rafts.
T2117	5027-5038	RB	denotes	Furthermore
T2118	5045-5052	VBP	denotes	contain
T2119	5038-5040	,	denotes	,
T2120	5040-5044	PRP	denotes	they
T2121	5053-5059	NN	denotes	sorcin
T2122	5060-5063	CC	denotes	and
T2123	5064-5071	NN	denotes	annexin
T2124	5072-5074	NN	denotes	A7
T2125	5075-5083	VBN	denotes	attached
T2126	5084-5086	IN	denotes	to
T2127	5087-5090	DT	denotes	the
T2128	5097-5102	NNS	denotes	rafts
T2129	5091-5096	NN	denotes	lipid
T2130	5102-5103	.	denotes	.
T2131	5103-5152	sentence	denotes	Both proteins are more abundant in nanovesicles.
T2132	5104-5108	DT	denotes	Both
T2133	5109-5117	NN	denotes	proteins
T2134	5118-5121	VBP	denotes	are
T2135	5122-5126	RBR	denotes	more
T2136	5127-5135	JJ	denotes	abundant
T2137	5136-5138	IN	denotes	in
T2138	5139-5151	NNS	denotes	nanovesicles
T2139	5151-5152	.	denotes	.
T2140	5152-5337	sentence	denotes	The vesicle formation goes along with several other changes in the red blood cell like cytoskeletal rearrangements and changes in the phospholipid orientation in the cellular membrane.
T2141	5153-5156	DT	denotes	The
T2142	5165-5174	NN	denotes	formation
T2143	5157-5164	NN	denotes	vesicle
T2144	5175-5179	VBZ	denotes	goes
T2145	5180-5185	RP	denotes	along
T2146	5186-5190	IN	denotes	with
T2147	5191-5198	JJ	denotes	several
T2148	5205-5212	NNS	denotes	changes
T2149	5199-5204	JJ	denotes	other
T2150	5213-5215	IN	denotes	in
T2151	5216-5219	DT	denotes	the
T2152	5230-5234	NN	denotes	cell
T2153	5220-5223	JJ	denotes	red
T2154	5224-5229	NN	denotes	blood
T2155	5235-5239	IN	denotes	like
T2156	5240-5252	JJ	denotes	cytoskeletal
T2157	5253-5267	NNS	denotes	rearrangements
T2158	5268-5271	CC	denotes	and
T2159	5272-5279	NNS	denotes	changes
T2160	5280-5282	IN	denotes	in
T2161	5283-5286	DT	denotes	the
T2162	5300-5311	NN	denotes	orientation
T2163	5287-5299	NN	denotes	phospholipid
T2164	5312-5314	IN	denotes	in
T2165	5315-5318	DT	denotes	the
T2166	5328-5336	NN	denotes	membrane
T2167	5319-5327	JJ	denotes	cellular
T2168	5336-5337	.	denotes	.
T1134	11-18	NN	denotes	Annexin
R314	T1134	T1135	compound	Annexin,A7
R315	T1135	T1136	nsubj	A7,is
R316	T1137	T1138	det	a,protein
R317	T1138	T1136	attr	protein,is
R318	T1139	T1140	npadvmod	Ca2+,binding
R319	T1140	T1138	amod	binding,protein
R320	T1141	T1139	punct	-,Ca2+
R321	T1142	T1139	cc	and,Ca2+
R322	T1143	T1139	conj	phospholipid,Ca2+
R323	T1144	T1140	punct	-,binding
R324	T1145	T1138	punct	", ",protein
R325	T1146	T1147	dep	which,isolated
R326	T1147	T1138	relcl	isolated,protein
R327	T1148	T1147	auxpass	was,isolated
R328	T1149	T1147	prep	as,isolated
R329	T1150	T1151	det	the,agent
R330	T1151	T1149	pobj	agent,as
R331	T1152	T1153	dep	that,mediated
R332	T1153	T1151	relcl	mediated,agent
R333	T1154	T1153	dobj	aggregation,mediated
R334	T1155	T1154	prep	of,aggregation
R335	T1156	T1157	compound	chromaffin,granules
R336	T1157	T1155	pobj	granules,of
R337	T1158	T1154	cc	and,aggregation
R338	T1159	T1154	conj	fusion,aggregation
R339	T1160	T1159	prep	of,fusion
R340	T1161	T1162	compound	phospholipid,membranes
R341	T1162	T1160	pobj	membranes,of
R342	T1163	T1154	prep	in,aggregation
R343	T1164	T1165	det	the,presence
R344	T1165	T1163	pobj	presence,in
R345	T1166	T1165	prep	of,presence
R346	T1167	T1166	pobj	Ca2+,of
R347	T1168	T1136	punct	.,is
R348	T1170	T1171	det	This,activity
R349	T1171	T1172	nsubj	activity,led
R350	T1173	T1172	prep	to,led
R351	T1174	T1175	det	the,proposal
R352	T1175	T1173	pobj	proposal,to
R353	T1176	T1175	prep	of,proposal
R354	T1177	T1178	compound	annexin,A7
R355	T1178	T1179	poss	A7,involvement
R356	T1179	T1176	pobj	involvement,of
R357	T1180	T1178	case	's,A7
R358	T1181	T1179	prep	in,involvement
R359	T1182	T1183	det	the,secretion
R360	T1183	T1181	pobj	secretion,in
R361	T1184	T1183	amod	exocytotic,secretion
R362	T1185	T1183	prep	of,secretion
R363	T1186	T1185	pobj	catecholamines,of
R364	T1187	T1188	punct	[,1
R365	T1188	T1172	parataxis	1,led
R366	T1189	T1188	punct	],1
R367	T1190	T1172	punct	.,led
R368	T1192	T1193	det	The,protein
R369	T1193	T1194	nsubj	protein,belongs
R370	T1195	T1194	prep	to,belongs
R371	T1196	T1197	det	a,family
R372	T1197	T1195	pobj	family,to
R373	T1198	T1197	prep	of,family
R374	T1199	T1200	advmod	evolutionarily,conserved
R375	T1200	T1201	amod	conserved,proteins
R376	T1201	T1198	pobj	proteins,of
R377	T1202	T1201	prep	of,proteins
R378	T1203	T1204	det	a,structure
R379	T1204	T1202	pobj	structure,of
R380	T1205	T1204	amod	bipartite,structure
R381	T1206	T1201	prep	with,proteins
R382	T1207	T1208	det	a,variable
R383	T1208	T1206	pobj	variable,with
R384	T1209	T1210	npadvmod	N,terminal
R385	T1210	T1208	amod	terminal,variable
R386	T1211	T1210	punct	-,terminal
R387	T1212	T1208	cc	and,variable
R388	T1213	T1214	det	a,conserved
R389	T1214	T1208	conj	conserved,variable
R390	T1215	T1216	npadvmod	C,terminal
R391	T1216	T1214	amod	terminal,conserved
R392	T1217	T1216	punct	-,terminal
R393	T1218	T1208	appos	domain,variable
R394	T1219	T1194	punct	.,belongs
R395	T1221	T1222	det	The,domain
R396	T1222	T1226	nsubj	domain,is
R397	T1223	T1224	npadvmod	C,terminal
R398	T1224	T1222	amod	terminal,domain
R399	T1225	T1224	punct	-,terminal
R400	T1226	T1227	ccomp	is,appears
R401	T1228	T1226	acomp	responsible,is
R402	T1229	T1228	prep	for,responsible
R403	T1230	T1231	det	the,Ca2+
R404	T1231	T1229	pobj	Ca2+,for
R405	T1232	T1231	punct	-,Ca2+
R406	T1233	T1231	cc	and,Ca2+
R407	T1234	T1231	conj	phospholipid,Ca2+
R408	T1235	T1231	punct	-,Ca2+
R409	T1236	T1231	amod	binding,Ca2+
R410	T1237	T1227	punct	", ",appears
R411	T1238	T1239	det	the,domain
R412	T1239	T1227	nsubj	domain,appears
R413	T1240	T1241	npadvmod	N,terminal
R414	T1241	T1239	amod	terminal,domain
R415	T1242	T1241	punct	-,terminal
R416	T1243	T1244	aux	to,confer
R417	T1244	T1227	xcomp	confer,appears
R418	T1245	T1246	amod	functional,diversity
R419	T1246	T1244	dobj	diversity,confer
R420	T1247	T1248	punct	[,2
R421	T1248	T1227	parataxis	2,appears
R422	T1249	T1250	punct	-,4
R423	T1250	T1248	prep	4,2
R424	T1251	T1248	punct	],2
R425	T1252	T1227	punct	.,appears
R426	T1254	T1255	det	The,binding
R427	T1255	T1256	nsubjpass	binding,thought
R428	T1257	T1255	prep	to,binding
R429	T1258	T1259	advmod	negatively,charged
R430	T1259	T1260	amod	charged,phospholipids
R431	T1260	T1257	pobj	phospholipids,to
R432	T1261	T1256	auxpass	is,thought
R433	T1262	T1263	aux	to,mediated
R434	T1263	T1256	xcomp	mediated,thought
R435	T1264	T1263	auxpass	be,mediated
R436	T1265	T1263	agent	by,mediated
R437	T1266	T1267	compound	Ca2+,ions
R438	T1267	T1265	pobj	ions,by
R439	T1268	T1256	punct	.,thought
R440	T1270	T1271	compound	Annexin,A7
R441	T1271	T1272	nsubj	A7,is
R442	T1273	T1272	acomp	unique,is
R443	T1274	T1275	mark	in,carries
R444	T1275	T1272	advcl	carries,is
R445	T1276	T1275	mark	that,carries
R446	T1277	T1275	nsubj	it,carries
R447	T1278	T1279	det	an,terminus
R448	T1279	T1275	dobj	terminus,carries
R449	T1280	T1281	advmod	extraordinarily,long
R450	T1281	T1279	amod	long,terminus
R451	T1282	T1281	cc	and,long
R452	T1283	T1281	conj	hydrophobic,long
R453	T1284	T1279	compound	amino,terminus
R454	T1285	T1279	prep	with,terminus
R455	T1286	T1287	amod	more,100
R456	T1287	T1289	nummod	100,acids
R457	T1288	T1287	quantmod	than,100
R458	T1289	T1285	pobj	acids,with
R459	T1290	T1289	compound	amino,acids
R460	T1291	T1272	punct	.,is
R461	T1293	T1294	amod	Alternative,splicing
R462	T1294	T1295	nsubj	splicing,gives
R463	T1296	T1295	dobj	rise,gives
R464	T1297	T1295	prep	to,gives
R465	T1298	T1299	nummod	two,isoforms
R466	T1299	T1297	pobj	isoforms,to
R467	T1300	T1299	prep	of,isoforms
R468	T1301	T1302	nummod	47,kDa
R469	T1302	T1300	pobj	kDa,of
R470	T1303	T1301	cc	and,47
R471	T1304	T1301	conj	51,47
R472	T1305	T1295	punct	.,gives
R473	T1307	T1308	det	Both,isoforms
R474	T1308	T1309	nsubj	isoforms,differ
R475	T1310	T1309	prep	by,differ
R476	T1311	T1312	det	an,exon
R477	T1312	T1310	pobj	exon,by
R478	T1313	T1312	amod	additional,exon
R479	T1314	T1312	compound	cassette,exon
R480	T1315	T1312	amod	located,exon
R481	T1316	T1315	prep	in,located
R482	T1317	T1318	det	the,third
R483	T1318	T1316	pobj	third,in
R484	T1319	T1318	amod	first,third
R485	T1320	T1318	prep	of,third
R486	T1321	T1322	det	the,domain
R487	T1322	T1320	pobj	domain,of
R488	T1323	T1324	npadvmod	N,terminal
R489	T1324	T1322	amod	terminal,domain
R490	T1325	T1324	punct	-,terminal
R491	T1326	T1309	punct	.,differ
R492	T1328	T1329	amod	Most,tissues
R493	T1329	T1330	nsubj	tissues,harbor
R494	T1330	T1331	ccomp	harbor,found
R495	T1332	T1333	advmod	only,isoform
R496	T1333	T1330	dobj	isoform,harbor
R497	T1334	T1333	det	the,isoform
R498	T1335	T1336	nummod	47,kDa
R499	T1336	T1333	compound	kDa,isoform
R500	T1337	T1331	punct	", ",found
R501	T1338	T1339	det	both,forms
R502	T1339	T1331	nsubjpass	forms,found
R503	T1340	T1331	auxpass	are,found
R504	T1341	T1331	prep	in,found
R505	T1342	T1341	pobj	brain,in
R506	T1343	T1342	cc	and,brain
R507	T1344	T1342	conj	heart,brain
R508	T1345	T1331	punct	", ",found
R509	T1346	T1347	prep	while,expressed
R510	T1347	T1331	advcl	expressed,found
R511	T1348	T1349	det	the,isoform
R512	T1349	T1347	nsubjpass	isoform,expressed
R513	T1350	T1349	amod	large,isoform
R514	T1351	T1347	auxpass	is,expressed
R515	T1352	T1347	advmod	exclusively,expressed
R516	T1353	T1347	prep	in,expressed
R517	T1354	T1355	amod	mature,muscle
R518	T1355	T1353	pobj	muscle,in
R519	T1356	T1355	amod	skeletal,muscle
R520	T1357	T1331	punct	.,found
R521	T1359	T1360	prep	At,detected
R522	T1361	T1362	det	the,level
R523	T1362	T1359	pobj	level,At
R524	T1363	T1362	amod	cellular,level
R525	T1364	T1365	compound	annexin,A7
R526	T1365	T1360	nsubjpass	A7,detected
R527	T1366	T1360	aux	can,detected
R528	T1367	T1360	auxpass	be,detected
R529	T1368	T1360	prep	in,detected
R530	T1369	T1370	det	the,cytosol
R531	T1370	T1368	pobj	cytosol,in
R532	T1371	T1368	punct	", ",in
R533	T1372	T1368	conj	at,in
R534	T1373	T1374	det	the,membrane
R535	T1374	T1372	pobj	membrane,at
R536	T1375	T1374	compound	plasma,membrane
R537	T1376	T1372	punct	", ",at
R538	T1377	T1372	conj	around,at
R539	T1378	T1379	det	the,nucleus
R540	T1379	T1377	pobj	nucleus,around
R541	T1380	T1377	punct	", ",around
R542	T1381	T1377	conj	at,around
R543	T1382	T1383	amod	vesicular,structures
R544	T1383	T1381	pobj	structures,at
R545	T1384	T1383	prep	including,structures
R546	T1385	T1386	amod	adrenal,granules
R547	T1386	T1384	pobj	granules,including
R548	T1387	T1386	compound	chromaffin,granules
R549	T1388	T1381	punct	", ",at
R550	T1389	T1381	cc	and,at
R551	T1390	T1381	conj	at,at
R552	T1391	T1392	det	the,system
R553	T1392	T1390	pobj	system,at
R554	T1393	T1394	compound	t,tubule
R555	T1394	T1392	compound	tubule,system
R556	T1395	T1394	punct	-,tubule
R557	T1396	T1397	punct	[,6
R558	T1397	T1360	parataxis	6,detected
R559	T1398	T1397	nummod	5,6
R560	T1399	T1397	punct	",",6
R561	T1400	T1397	punct	],6
R562	T1401	T1360	punct	.,detected
R563	T1403	T1404	compound	Annexin,A7
R564	T1404	T1405	nsubj	A7,translocates
R565	T1406	T1405	prep	to,translocates
R566	T1407	T1406	pobj	membranes,to
R567	T1408	T1405	prep	in,translocates
R568	T1409	T1410	det	a,fashion
R569	T1410	T1408	pobj	fashion,in
R570	T1411	T1412	npadvmod	Ca2+,dependent
R571	T1412	T1410	amod	dependent,fashion
R572	T1413	T1412	punct	-,dependent
R573	T1414	T1405	cc	and,translocates
R574	T1415	T1416	punct	", ",redistributes
R575	T1416	T1405	conj	redistributes,translocates
R576	T1417	T1418	advmod	when,rise
R577	T1418	T1416	advcl	rise,redistributes
R578	T1419	T1420	amod	intracellular,levels
R579	T1420	T1418	nsubj	levels,rise
R580	T1421	T1420	compound	Ca2+,levels
R581	T1422	T1416	punct	", ",redistributes
R582	T1423	T1416	advmod	sequentially,redistributes
R583	T1424	T1416	prep	to,redistributes
R584	T1425	T1426	det	the,plasma
R585	T1426	T1424	pobj	plasma,to
R586	T1427	T1426	cc	and,plasma
R587	T1428	T1429	det	the,membrane
R588	T1429	T1426	conj	membrane,plasma
R589	T1430	T1429	amod	nuclear,membrane
R590	T1431	T1432	advmod	as,as
R591	T1432	T1424	cc	as,to
R592	T1433	T1432	advmod	well,as
R593	T1434	T1424	conj	to,to
R594	T1435	T1436	amod	intracellular,vesicles
R595	T1436	T1434	pobj	vesicles,to
R596	T1437	T1405	punct	.,translocates
R597	T1439	T1440	advmod	Furthermore,associates
R598	T1441	T1440	punct	", ",associates
R599	T1442	T1443	compound	annexin,A7
R600	T1443	T1440	nsubj	A7,associates
R601	T1444	T1440	prep	with,associates
R602	T1445	T1446	compound	lipid,rafts
R603	T1446	T1444	pobj	rafts,with
R604	T1447	T1448	punct	[,7
R605	T1448	T1440	parataxis	7,associates
R606	T1449	T1448	punct	],7
R607	T1450	T1440	punct	.,associates
R608	T1452	T1453	compound	Lipid,rafts
R609	T1453	T1454	nsubj	rafts,play
R610	T1455	T1456	det	a,role
R611	T1456	T1454	dobj	role,play
R612	T1457	T1456	amod	key,role
R613	T1458	T1454	prep	in,play
R614	T1459	T1460	compound	membrane,budding
R615	T1460	T1458	pobj	budding,in
R616	T1461	T1458	cc	and,in
R617	T1462	T1458	conj	in,in
R618	T1463	T1464	compound	vesiculation,processes
R619	T1464	T1462	pobj	processes,in
R620	T1465	T1466	amod	such,as
R621	T1466	T1464	prep	as,processes
R622	T1467	T1468	nmod	endo,exocytosis
R623	T1468	T1466	pobj	exocytosis,as
R624	T1469	T1468	punct	-,exocytosis
R625	T1470	T1468	cc	and,exocytosis
R626	T1471	T1472	punct	[,8
R627	T1472	T1454	parataxis	8,play
R628	T1473	T1474	punct	-,10
R629	T1474	T1472	prep	10,8
R630	T1475	T1472	punct	],8
R631	T1476	T1454	punct	.,play
R632	T1478	T1479	nummod	Two,partners
R633	T1479	T1481	nsubjpass	partners,identified
R634	T1480	T1479	amod	binding,partners
R635	T1482	T1479	prep	of,partners
R636	T1483	T1484	compound	annexin,A7
R637	T1484	T1482	pobj	A7,of
R638	T1485	T1481	aux	have,identified
R639	T1486	T1481	auxpass	been,identified
R640	T1487	T1481	punct	", ",identified
R641	T1488	T1481	dobj	sorcin,identified
R642	T1489	T1488	cc	and,sorcin
R643	T1490	T1488	conj	galectin,sorcin
R644	T1491	T1490	punct	-,galectin
R645	T1492	T1490	nummod	3,galectin
R646	T1493	T1494	punct	[,11
R647	T1494	T1481	parataxis	11,identified
R648	T1495	T1496	punct	-,13
R649	T1496	T1494	prep	13,11
R650	T1497	T1494	punct	],11
R651	T1498	T1481	punct	.,identified
R652	T1500	T1501	nsubj	Sorcin,is
R653	T1502	T1503	det	a,protein
R654	T1503	T1501	attr	protein,is
R655	T1504	T1505	npadvmod	Ca2+,binding
R656	T1505	T1503	amod	binding,protein
R657	T1506	T1505	punct	-,binding
R658	T1507	T1501	cc	and,is
R659	T1508	T1501	conj	belongs,is
R660	T1509	T1508	prep	to,belongs
R661	T1510	T1511	det	the,family
R662	T1511	T1509	pobj	family,to
R663	T1512	T1513	compound	penta,protein
R664	T1513	T1511	compound	protein,family
R665	T1514	T1515	compound	EF,hand
R666	T1515	T1513	compound	hand,protein
R667	T1516	T1515	punct	-,hand
R668	T1517	T1518	punct	[,14
R669	T1518	T1508	parataxis	14,belongs
R670	T1519	T1518	punct	],14
R671	T1520	T1501	punct	.,is
R672	T1522	T1523	prep	Like,binds
R673	T1524	T1525	compound	annexin,A7
R674	T1525	T1522	pobj	A7,Like
R675	T1526	T1523	nsubj	it,binds
R676	T1527	T1523	prep	to,binds
R677	T1528	T1527	pobj	membranes,to
R678	T1529	T1523	prep	in,binds
R679	T1530	T1531	det	a,manner
R680	T1531	T1529	pobj	manner,in
R681	T1532	T1533	npadvmod	Ca2+,dependent
R682	T1533	T1531	amod	dependent,manner
R683	T1534	T1533	punct	-,dependent
R684	T1535	T1523	punct	.,binds
R685	T1537	T1538	nsubjpass	Sorcin,described
R686	T1539	T1538	advmod	also,described
R687	T1540	T1538	aux	has,described
R688	T1541	T1538	auxpass	been,described
R689	T1542	T1538	prep	as,described
R690	T1543	T1544	compound	interaction,partner
R691	T1544	T1542	pobj	partner,as
R692	T1545	T1544	prep	of,partner
R693	T1546	T1547	det	the,receptor
R694	T1547	T1545	pobj	receptor,of
R695	T1548	T1547	compound	ryanodine,receptor
R696	T1549	T1538	punct	", ",described
R697	T1550	T1538	cc	and,described
R698	T1551	T1538	conj	appears,described
R699	T1552	T1553	aux	to,modulate
R700	T1553	T1551	xcomp	modulate,appears
R701	T1554	T1555	poss	its,function
R702	T1555	T1553	dobj	function,modulate
R703	T1556	T1557	punct	[,15
R704	T1557	T1551	parataxis	15,appears
R705	T1558	T1557	punct	],15
R706	T1559	T1538	punct	.,described
R707	T1561	T1562	det	The,influence
R708	T1562	T1563	nsubj	influence,is
R709	T1564	T1562	prep	of,influence
R710	T1565	T1566	det	the,interaction
R711	T1566	T1564	pobj	interaction,of
R712	T1567	T1568	compound	sorcin,annexin
R713	T1568	T1570	compound	annexin,A7
R714	T1569	T1568	punct	/,annexin
R715	T1570	T1566	compound	A7,interaction
R716	T1571	T1562	prep	on,influence
R717	T1572	T1573	det	the,receptor
R718	T1573	T1571	pobj	receptor,on
R719	T1574	T1573	compound	ryanodine,receptor
R720	T1575	T1563	acomp	unknown,is
R721	T1576	T1563	punct	.,is
R722	T1578	T1579	nsubjpass	Sorcin,coexpressed
R723	T1580	T1578	cc	and,Sorcin
R724	T1581	T1582	compound	annexin,A7
R725	T1582	T1578	conj	A7,Sorcin
R726	T1583	T1579	auxpass	are,coexpressed
R727	T1584	T1579	prep	in,coexpressed
R728	T1585	T1586	det	all,tissues
R729	T1586	T1584	pobj	tissues,in
R730	T1587	T1586	acl	examined,tissues
R731	T1588	T1589	advmod	so,far
R732	T1589	T1587	advmod	far,examined
R733	T1590	T1591	punct	[,11
R734	T1591	T1579	parataxis	11,coexpressed
R735	T1592	T1591	punct	],11
R736	T1593	T1579	punct	.,coexpressed
R737	T1595	T1596	det	The,binding
R738	T1596	T1597	nsubj	binding,is
R739	T1598	T1596	prep	of,binding
R740	T1599	T1600	compound	annexin,A7
R741	T1600	T1598	pobj	A7,of
R742	T1601	T1600	cc	and,A7
R743	T1602	T1600	conj	sorcin,A7
R744	T1603	T1604	npadvmod	Ca2+,dependent
R745	T1604	T1597	acomp	dependent,is
R746	T1605	T1604	punct	-,dependent
R747	T1606	T1597	cc	and,is
R748	T1607	T1597	conj	occurs,is
R749	T1608	T1607	prep	at,occurs
R750	T1609	T1610	amod	micromolar,Ca2+
R751	T1610	T1611	compound	Ca2+,concentrations
R752	T1611	T1608	pobj	concentrations,at
R753	T1612	T1597	punct	.,is
R754	T1614	T1615	det	The,sites
R755	T1615	T1617	nsubjpass	sites,localised
R756	T1616	T1615	amod	binding,sites
R757	T1618	T1617	aux	have,localised
R758	T1619	T1617	auxpass	been,localised
R759	T1620	T1617	prep	to,localised
R760	T1621	T1622	det	the,motifs
R761	T1622	T1620	pobj	motifs,to
R762	T1623	T1624	npadvmod	amino,terminal
R763	T1624	T1622	amod	terminal,motifs
R764	T1625	T1622	nmod	GGYY,motifs
R765	T1626	T1625	cc	and,GGYY
R766	T1627	T1625	conj	GYGG,GGYY
R767	T1628	T1622	prep	in,motifs
R768	T1629	T1628	pobj	sorcin,in
R769	T1630	T1620	cc	and,to
R770	T1631	T1620	conj	to,to
R771	T1632	T1633	det	the,motif
R772	T1633	T1631	pobj	motif,to
R773	T1634	T1633	compound	GYPP,motif
R774	T1635	T1633	prep	in,motif
R775	T1636	T1637	det	the,terminus
R776	T1637	T1635	pobj	terminus,in
R777	T1638	T1637	compound	amino,terminus
R778	T1639	T1637	prep	of,terminus
R779	T1640	T1641	compound	annexin,A7
R780	T1641	T1639	pobj	A7,of
R781	T1642	T1617	punct	.,localised
R782	T1644	T1645	det	The,proteins
R783	T1645	T1646	nsubj	proteins,bind
R784	T1647	T1646	prep	to,bind
R785	T1648	T1649	det	each,other
R786	T1649	T1647	pobj	other,to
R787	T1650	T1646	prep	with,bind
R788	T1651	T1652	det	a,stoichiometry
R789	T1652	T1650	pobj	stoichiometry,with
R790	T1653	T1652	prep	of,stoichiometry
R791	T1654	T1655	nummod	two,molecules
R792	T1655	T1653	pobj	molecules,of
R793	T1656	T1655	compound	sorcin,molecules
R794	T1657	T1655	prep	per,molecules
R795	T1658	T1659	compound	annexin,A7
R796	T1659	T1660	compound	A7,molecule
R797	T1660	T1657	pobj	molecule,per
R798	T1661	T1662	punct	[,12
R799	T1662	T1646	parataxis	12,bind
R800	T1663	T1662	punct	],12
R801	T1664	T1646	punct	.,bind
R802	T1666	T1667	nsubj	Galectin,is
R803	T1668	T1666	punct	-,Galectin
R804	T1669	T1666	nummod	3,Galectin
R805	T1670	T1671	det	a,protein
R806	T1671	T1667	attr	protein,is
R807	T1672	T1671	amod	multifunctional,protein
R808	T1673	T1671	amod	oncogenic,protein
R809	T1674	T1671	prep	with,protein
R810	T1675	T1676	det	an,activity
R811	T1676	T1674	pobj	activity,with
R812	T1677	T1676	amod	anti-apoptotic,activity
R813	T1678	T1671	acl	found,protein
R814	T1679	T1678	prep	in,found
R815	T1680	T1681	det	the,space
R816	T1681	T1679	pobj	space,in
R817	T1682	T1681	amod	extracellular,space
R818	T1683	T1681	punct	", ",space
R819	T1684	T1681	prep	in,space
R820	T1685	T1686	det	the,nucleus
R821	T1686	T1684	pobj	nucleus,in
R822	T1687	T1686	cc	and,nucleus
R823	T1688	T1686	conj	cytoplasm,nucleus
R824	T1689	T1679	cc	and,in
R825	T1690	T1679	conj	in,in
R826	T1691	T1690	pobj	mitochondria,in
R827	T1692	T1667	punct	.,is
R828	T1694	T1695	amod	Cytoplasmic,galectin
R829	T1695	T1696	nsubj	galectin,correlates
R830	T1697	T1695	punct	-,galectin
R831	T1698	T1695	nummod	3,galectin
R832	T1699	T1696	prep	with,correlates
R833	T1700	T1701	compound	tumor,progression
R834	T1701	T1699	pobj	progression,with
R835	T1702	T1696	cc	and,correlates
R836	T1703	T1696	conj	protects,correlates
R837	T1704	T1705	amod	mitochondrial,integrity
R838	T1705	T1703	dobj	integrity,protects
R839	T1706	T1696	punct	.,correlates
R840	T1708	T1709	compound	Down,regulation
R841	T1709	T1710	nsubj	regulation,prevents
R842	T1711	T1709	prep	of,regulation
R843	T1712	T1713	compound	annexin,A7
R844	T1713	T1711	pobj	A7,of
R845	T1714	T1715	compound	galectin,3
R846	T1715	T1717	compound	3,translocation
R847	T1716	T1715	punct	-,3
R848	T1717	T1710	dobj	translocation,prevents
R849	T1718	T1717	prep	to,translocation
R850	T1719	T1720	det	the,membrane
R851	T1720	T1718	pobj	membrane,to
R852	T1721	T1720	amod	perinuclear,membrane
R853	T1722	T1710	cc	and,prevents
R854	T1723	T1710	conj	increases,prevents
R855	T1724	T1725	compound	galectin,3
R856	T1725	T1727	compound	3,secretion
R857	T1726	T1725	punct	-,3
R858	T1727	T1723	dobj	secretion,increases
R859	T1728	T1710	punct	.,prevents
R860	T1730	T1731	prep	For,proposed
R861	T1732	T1733	compound	annexin,A7
R862	T1733	T1730	pobj	A7,For
R863	T1734	T1735	det	a,role
R864	T1735	T1731	nsubjpass	role,proposed
R865	T1736	T1735	prep	for,role
R866	T1737	T1738	compound	galectin,3
R867	T1738	T1740	compound	3,trafficking
R868	T1739	T1738	punct	-,3
R869	T1740	T1736	pobj	trafficking,for
R870	T1741	T1740	punct	", ",trafficking
R871	T1742	T1743	compound	apoptosis,regulation
R872	T1743	T1740	conj	regulation,trafficking
R873	T1744	T1743	punct	", ",regulation
R874	T1745	T1743	cc	and,regulation
R875	T1746	T1747	amod	mitochondrial,integrity
R876	T1747	T1743	conj	integrity,regulation
R877	T1748	T1731	auxpass	was,proposed
R878	T1749	T1750	punct	[,13
R879	T1750	T1731	parataxis	13,proposed
R880	T1751	T1750	punct	],13
R881	T1752	T1731	punct	.,proposed
R882	T1754	T1755	det	The,role
R883	T1755	T1757	nsubjpass	role,understood
R884	T1756	T1755	amod	cellular,role
R885	T1758	T1755	prep	of,role
R886	T1759	T1760	compound	annexin,A7
R887	T1760	T1758	pobj	A7,of
R888	T1761	T1757	auxpass	is,understood
R889	T1762	T1757	neg	not,understood
R890	T1763	T1757	advmod	well,understood
R891	T1764	T1757	punct	.,understood
R892	T1766	T1767	nsubjpass	It,thought
R893	T1768	T1767	auxpass	is,thought
R894	T1769	T1770	aux	to,regulate
R895	T1770	T1767	xcomp	regulate,thought
R896	T1771	T1770	cc	and,regulate
R897	T1772	T1770	conj	stabilize,regulate
R898	T1773	T1774	compound	membrane,domains
R899	T1774	T1772	dobj	domains,stabilize
R900	T1775	T1770	cc	and,regulate
R901	T1776	T1777	aux	to,have
R902	T1777	T1770	conj	have,regulate
R903	T1778	T1779	det	a,role
R904	T1779	T1777	dobj	role,have
R905	T1780	T1777	prep	in,have
R906	T1781	T1782	compound	Ca2+,homeostasis
R907	T1782	T1780	pobj	homeostasis,in
R908	T1783	T1782	cc	and,homeostasis
R909	T1784	T1785	npadvmod	Ca2+,dependent
R910	T1785	T1787	amod	dependent,pathways
R911	T1786	T1785	punct	-,dependent
R912	T1787	T1782	conj	pathways,homeostasis
R913	T1788	T1787	compound	signaling,pathways
R914	T1789	T1767	punct	.,thought
R915	T1791	T1792	det	These,proposals
R916	T1792	T1793	nsubjpass	proposals,supported
R917	T1794	T1793	auxpass	are,supported
R918	T1795	T1793	agent	by,supported
R919	T1796	T1795	pobj	data,by
R920	T1797	T1796	acl	obtained,data
R921	T1798	T1797	prep	from,obtained
R922	T1799	T1798	pobj	analysis,from
R923	T1800	T1799	prep	of,analysis
R924	T1801	T1802	compound	annexin,A7
R925	T1802	T1803	npadvmod	A7,deficient
R926	T1803	T1804	amod	deficient,mutants
R927	T1804	T1800	pobj	mutants,of
R928	T1805	T1804	compound	mouse,mutants
R929	T1806	T1793	punct	.,supported
R930	T1808	T1809	nummod	Two,strains
R931	T1809	T1815	nsubjpass	strains,generated
R932	T1810	T1811	nmod	annexin,A7
R933	T1811	T1809	nmod	A7,strains
R934	T1812	T1809	nmod	129Sv,strains
R935	T1919	T1917	cc	and,cells
R936	T1813	T1809	amod	null,strains
R937	T1920	T1917	conj	platelets,cells
R938	T1814	T1809	compound	mice,strains
R939	T1921	T1914	auxpass	were,thought
R940	T1816	T1815	auxpass	were,generated
R941	T1817	T1815	advmod	independently,generated
R942	T1922	T1914	neg	not,thought
R943	T1818	T1815	advcl	using,generated
R944	T1819	T1820	det	a,strategy
R945	T1923	T1924	aux	to,contain
R946	T1820	T1818	dobj	strategy,using
R947	T1821	T1820	amod	different,strategy
R948	T1924	T1914	xcomp	contain,thought
R949	T1822	T1815	punct	.,generated
R950	T1824	T1825	det	The,one
R951	T1925	T1926	compound	annexin,A7
R952	T1825	T1826	nsubj	one,is
R953	T1926	T1924	dobj	A7,contain
R954	T1927	T1914	cc	and,thought
R955	T1928	T1929	advmod	only,recently
R956	T1827	T1825	prep	of,one
R957	T1929	T1930	advmod	recently,reported
R958	T1828	T1827	pobj	Srivastava,of
R959	T1829	T1830	advmod	et,al.
R960	T1830	T1828	advmod	al.,Srivastava
R961	T1930	T1914	conj	reported,thought
R962	T1831	T1832	punct	[,16
R963	T1832	T1828	parataxis	16,Srivastava
R964	T1931	T1932	det	the,isoform
R965	T1833	T1832	punct	],16
R966	T1834	T1826	acomp	lethal,is
R967	T1835	T1826	punct	.,is
R968	T1932	T1930	nsubjpass	isoform,reported
R969	T1837	T1838	amod	Heterozygous,mice
R970	T1933	T1934	nummod	47,kDa
R971	T1838	T1839	nsubj	mice,exhibit
R972	T1934	T1932	compound	kDa,isoform
R973	T1840	T1841	det	an,defect
R974	T1841	T1839	dobj	defect,exhibit
R975	T1842	T1843	compound	insulin,secretion
R976	T1935	T1930	aux	has,reported
R977	T1843	T1841	compound	secretion,defect
R978	T1844	T1841	cc	and,defect
R979	T1845	T1846	compound	tumor,phenotypes
R980	T1936	T1930	auxpass	been,reported
R981	T1846	T1841	conj	phenotypes,defect
R982	T1847	T1839	punct	.,exhibit
R983	T1937	T1930	prep	as,reported
R984	T1849	T1850	det	The,strain
R985	T1850	T1852	nsubj	strain,is
R986	T1851	T1850	amod	null,strain
R987	T1853	T1850	acl	reported,strain
R988	T1938	T1937	pobj	component,as
R989	T1854	T1853	agent	by,reported
R990	T1855	T1854	pobj	Herr,by
R991	T1939	T1938	prep	of,component
R992	T1856	T1857	advmod	et,al.
R993	T1857	T1855	advmod	al.,Herr
R994	T1858	T1859	punct	[,17
R995	T1940	T1941	amod	red,cells
R996	T1859	T1853	parataxis	17,reported
R997	T1860	T1859	punct	],17
R998	T1941	T1939	pobj	cells,of
R999	T1861	T1862	amod	viable,healthy
R1000	T1862	T1852	acomp	healthy,is
R1001	T1863	T1862	punct	", ",healthy
R1002	T1942	T1941	compound	blood,cells
R1003	T1864	T1852	punct	", ",is
R1004	T1865	T1852	cc	and,is
R1005	T1943	T1944	punct	[,7
R1006	T1866	T1852	conj	shows,is
R1007	T1867	T1868	det	no,defect
R1008	T1868	T1866	dobj	defect,shows
R1009	T1944	T1930	parataxis	7,reported
R1010	T1869	T1870	compound	insulin,secretion
R1011	T1870	T1868	compound	secretion,defect
R1012	T1945	T1944	punct	],7
R1013	T1871	T1868	cc	or,defect
R1014	T1946	T1914	punct	.,thought
R1015	T1872	T1873	amod	other,defects
R1016	T1948	T1949	amod	Red,cells
R1017	T1873	T1868	conj	defects,defect
R1018	T1874	T1873	amod	obvious,defects
R1019	T1875	T1852	punct	.,is
R1020	T1949	T1951	nsubj	cells,undergo
R1021	T1877	T1878	advmod	However,disturbed
R1022	T1950	T1949	compound	blood,cells
R1023	T1879	T1878	punct	", ",disturbed
R1024	T1880	T1878	prep	in,disturbed
R1025	T1952	T1953	amod	various,changes
R1026	T1881	T1882	amod	isolated,cardiomyocytes
R1027	T1882	T1880	pobj	cardiomyocytes,in
R1028	T1883	T1884	det	the,shortening
R1029	T1953	T1951	dobj	changes,undergo
R1030	T1884	T1878	nsubjpass	shortening,disturbed
R1031	T1885	T1886	npadvmod	frequency,induced
R1032	T1954	T1953	amod	biochemical,changes
R1033	T1886	T1884	amod	induced,shortening
R1034	T1887	T1886	punct	-,induced
R1035	T1888	T1878	auxpass	is,disturbed
R1036	T1889	T1878	punct	.,disturbed
R1037	T1955	T1954	cc	or,biochemical
R1038	T1891	T1892	advmod	Here,focused
R1039	T1956	T1954	conj	morphological,biochemical
R1040	T1893	T1892	nsubj	we,focused
R1041	T1957	T1958	dep	that,appear
R1042	T1894	T1892	aux	have,focused
R1043	T1895	T1892	prep	on,focused
R1044	T1896	T1897	det	the,analysis
R1045	T1958	T1953	relcl	appear,changes
R1046	T1897	T1895	pobj	analysis,on
R1047	T1898	T1897	prep	of,analysis
R1048	T1959	T1960	aux	to,be
R1049	T1899	T1900	amod	red,cells
R1050	T1900	T1898	pobj	cells,of
R1051	T1901	T1900	compound	blood,cells
R1052	T1960	T1958	xcomp	be,appear
R1053	T1902	T1900	cc	and,cells
R1054	T1903	T1900	conj	platelets,cells
R1055	T1904	T1900	prep	of,cells
R1056	T1961	T1962	npadvmod	Ca2+,dependent
R1057	T1905	T1906	det	the,mutant
R1058	T1906	T1904	pobj	mutant,of
R1059	T1907	T1906	nmod	anxA7,mutant
R1060	T1962	T1964	amod	dependent,processes
R1061	T1908	T1907	punct	-,anxA7
R1062	T1909	T1907	punct	/,anxA7
R1063	T1963	T1962	punct	-,dependent
R1064	T1910	T1907	punct	-,anxA7
R1065	T1911	T1892	punct	.,focused
R1066	T1964	T1960	attr	processes,be
R1067	T1913	T1914	advmod	Generally,thought
R1068	T1915	T1914	punct	", ",thought
R1069	T1965	T1966	punct	[,19
R1070	T1916	T1917	amod	red,cells
R1071	T1917	T1914	nsubjpass	cells,thought
R1072	T1966	T1951	parataxis	19,undergo
R1073	T1918	T1917	compound	blood,cells
R1074	T1967	T1966	nummod	18,19
R1075	T1968	T1966	punct	",",19
R1076	T1969	T1966	punct	],19
R1077	T1970	T1951	punct	.,undergo
R1078	T1972	T1973	nsubj	One,is
R1079	T2026	T2027	dep	which,lack
R1080	T2027	T2023	relcl	lack,cells
R1081	T1974	T1972	prep	of,One
R1082	T2028	T2029	det	the,ability
R1083	T2029	T2027	dobj	ability,lack
R1084	T2030	T2031	aux	to,vesiculate
R1085	T1975	T1974	pobj	them,of
R1086	T2031	T2029	acl	vesiculate,ability
R1087	T2032	T2033	det	a,disease
R1088	T2033	T2025	dobj	disease,cause
R1089	T2034	T2025	prep	with,cause
R1090	T2035	T2036	amod	red,cell
R1091	T2036	T2038	compound	cell,destruction
R1092	T1976	T1977	det	the,release
R1093	T2037	T2036	compound	blood,cell
R1094	T2038	T2034	pobj	destruction,with
R1095	T2039	T2038	cc	and,destruction
R1096	T1977	T1973	attr	release,is
R1097	T2040	T2038	conj	haemoglobinuria,destruction
R1098	T2041	T2042	punct	[,21
R1099	T1978	T1977	prep	of,release
R1100	T2042	T2025	parataxis	21,cause
R1101	T2043	T2042	punct	],21
R1102	T1979	T1980	npadvmod	hemoglobin,containing
R1103	T2044	T2025	punct	.,cause
R1104	T2046	T2047	expl	There,exist
R1105	T1980	T1982	amod	containing,exovesicles
R1106	T2048	T2049	nummod	two,types
R1107	T2049	T2047	dobj	types,exist
R1108	T1981	T1980	punct	-,containing
R1109	T1982	T1978	pobj	exovesicles,of
R1110	T2050	T2049	prep	of,types
R1111	T2051	T2050	pobj	vesicles,of
R1112	T1983	T1977	acl	occurring,release
R1113	T2052	T2049	punct	", ",types
R1114	T2053	T2054	nmod	micro,nanovesicles
R1115	T1984	T1985	advmod	in,vivo
R1116	T2054	T2049	appos	nanovesicles,types
R1117	T2055	T2054	punct	-,nanovesicles
R1118	T2056	T2054	cc	and,nanovesicles
R1119	T1985	T1983	advmod	vivo,occurring
R1120	T2057	T2049	prep	with,types
R1121	T2058	T2059	det	a,size
R1122	T1986	T1987	advmod	as,as
R1123	T2059	T2057	pobj	size,with
R1124	T2060	T2059	prep	of,size
R1125	T1987	T1985	cc	as,vivo
R1126	T2061	T2062	nummod	180,nm
R1127	T2062	T2060	pobj	nm,of
R1128	T2063	T2062	cc	and,nm
R1129	T1988	T1987	advmod	well,as
R1130	T2064	T2065	nummod	60,nm
R1131	T2065	T2062	conj	nm,nm
R1132	T1989	T1990	advmod	in,vitro
R1133	T2066	T2047	punct	", ",exist
R1134	T2067	T2047	advmod	respectively,exist
R1135	T2068	T2047	punct	.,exist
R1136	T1990	T1985	conj	vitro,vivo
R1137	T2070	T2071	nsubjpass	They,enriched
R1138	T1991	T1992	punct	[,20
R1139	T2072	T2071	auxpass	are,enriched
R1140	T2073	T2071	prep	in,enriched
R1141	T2074	T2075	npadvmod	cholesterol,rich
R1142	T2075	T2078	amod	rich,domains
R1143	T2076	T2074	cc	and,cholesterol
R1144	T1992	T1973	parataxis	20,is
R1145	T2077	T2074	conj	sphingolipid,cholesterol
R1146	T2078	T2073	pobj	domains,in
R1147	T2079	T2080	compound	lipid,raft
R1148	T1993	T1992	nummod	7,20
R1149	T2080	T2078	compound	raft,domains
R1150	T2081	T2082	dep	that,associated
R1151	T2082	T2078	relcl	associated,domains
R1152	T1994	T1992	punct	",",20
R1153	T2083	T2082	auxpass	are,associated
R1154	T2084	T2082	prep	with,associated
R1155	T1995	T1992	punct	],20
R1156	T2085	T2084	pobj	proteins,with
R1157	T2086	T2085	prep	like,proteins
R1158	T1996	T1973	punct	.,is
R1159	T2087	T2086	pobj	acetylcholinesterase,like
R1160	T2088	T2087	punct	", ",acetylcholinesterase
R1161	T2089	T2090	compound	cell,proteins
R1162	T1998	T1999	det	This,process
R1163	T2090	T2087	conj	proteins,acetylcholinesterase
R1164	T2091	T2090	compound	surface,proteins
R1165	T2092	T2090	prep	including,proteins
R1166	T1999	T2000	nsubjpass	process,thought
R1167	T2093	T2094	det	a,receptor
R1168	T2094	T2092	pobj	receptor,including
R1169	T2095	T2094	compound	complement,receptor
R1170	T2001	T2000	auxpass	is,thought
R1171	T2096	T2090	punct	", ",proteins
R1172	T2097	T2090	cc	and,proteins
R1173	T2098	T2099	det	the,proteins
R1174	T2099	T2090	conj	proteins,proteins
R1175	T2002	T2003	aux	to,represent
R1176	T2100	T2101	compound	lipid,raft
R1177	T2101	T2099	compound	raft,proteins
R1178	T2102	T2099	appos	stomatin,proteins
R1179	T2003	T2000	xcomp	represent,thought
R1180	T2103	T2102	cc	and,stomatin
R1181	T2104	T2102	conj	flotillin,stomatin
R1182	T2105	T2071	punct	", ",enriched
R1183	T2004	T2005	det	a,method
R1184	T2106	T2071	cc	but,enriched
R1185	T2107	T2108	nsubj	they,lack
R1186	T2005	T2003	dobj	method,represent
R1187	T2108	T2071	conj	lack,enriched
R1188	T2109	T2110	det	any,protein
R1189	T2006	T2005	amod	protective,method
R1190	T2110	T2108	dobj	protein,lack
R1191	T2111	T2110	amod	cytoskeletal,protein
R1192	T2112	T2113	punct	[,7
R1193	T2113	T2108	parataxis	7,lack
R1194	T2114	T2113	punct	],7
R1195	T2115	T2108	punct	.,lack
R1196	T2007	T2005	prep	of,method
R1197	T2117	T2118	advmod	Furthermore,contain
R1198	T2008	T2009	det	the,cell
R1199	T2119	T2118	punct	", ",contain
R1200	T2120	T2118	nsubj	they,contain
R1201	T2009	T2007	pobj	cell,of
R1202	T2121	T2118	dobj	sorcin,contain
R1203	T2122	T2121	cc	and,sorcin
R1204	T2010	T2009	amod	red,cell
R1205	T2123	T2124	compound	annexin,A7
R1206	T2124	T2121	conj	A7,sorcin
R1207	T2125	T2121	acl	attached,sorcin
R1208	T2011	T2009	compound	blood,cell
R1209	T2012	T2005	prep	against,method
R1210	T2126	T2125	prep	to,attached
R1211	T2013	T2014	det	an,attack
R1212	T2127	T2128	det	the,rafts
R1213	T2128	T2126	pobj	rafts,to
R1214	T2014	T2012	pobj	attack,against
R1216	T2130	T2118	punct	.,contain
R1217	T2015	T2014	prep	by,attack
R1218	T2016	T2017	prep	for,components
R1219	T2017	T2015	pobj	components,by
R1220	T2132	T2133	det	Both,proteins
R1221	T2133	T2134	nsubj	proteins,are
R1222	T2018	T2016	pobj	example,for
R1223	T2135	T2136	advmod	more,abundant
R1224	T2136	T2134	acomp	abundant,are
R1225	T2019	T2017	compound	complement,components
R1226	T2020	T2000	punct	.,thought
R1227	T2137	T2134	prep	in,are
R1228	T2138	T2137	pobj	nanovesicles,in
R1229	T2022	T2023	amod	Red,cells
R1230	T2139	T2134	punct	.,are
R1231	T2141	T2142	det	The,formation
R1232	T2142	T2144	nsubj	formation,goes
R1233	T2023	T2025	nsubj	cells,cause
R1234	T2143	T2142	compound	vesicle,formation
R1235	T2024	T2023	compound	blood,cells
R1236	T2145	T2144	prt	along,goes
R1237	T2146	T2144	prep	with,goes
R1238	T2147	T2148	amod	several,changes
R1239	T2148	T2146	pobj	changes,with
R1240	T2149	T2148	amod	other,changes
R1241	T2150	T2148	prep	in,changes
R1242	T2151	T2152	det	the,cell
R1243	T2152	T2150	pobj	cell,in
R1244	T2153	T2152	amod	red,cell
R1245	T2154	T2152	compound	blood,cell
R1246	T2155	T2148	prep	like,changes
R1247	T2156	T2157	amod	cytoskeletal,rearrangements
R1248	T2157	T2155	pobj	rearrangements,like
R1249	T2158	T2157	cc	and,rearrangements
R1250	T2159	T2157	conj	changes,rearrangements
R1251	T2160	T2159	prep	in,changes
R1252	T2161	T2162	det	the,orientation
R1253	T2162	T2160	pobj	orientation,in
R1254	T2163	T2162	compound	phospholipid,orientation
R1255	T2164	T2159	prep	in,changes
R1256	T2165	T2166	det	the,membrane
R1257	T2166	T2164	pobj	membrane,in
R1258	T2167	T2166	amod	cellular,membrane
R1259	T2168	T2144	punct	.,goes
R1215	T2129	T2128	compound	lipid,rafts

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T726	11-21	PR:000004080	denotes	Annexin A7
T728	37-49	CHEBI:16247	denotes	phospholipid
T729	128-147	GO:0042583	denotes	chromaffin granules
T730	152-161	_FRAGMENT	denotes	fusion of
T731	175-184	GO:0061025	denotes	membranes
T732	162-174	CHEBI:16247	denotes	phospholipid
T733	175-184	GO:0016020	denotes	membranes
T734	204-208	CHEBI:29108	denotes	Ca2+
T735	247-257	PR:000004080	denotes	annexin A7
T736	279-289	GO:0006887	denotes	exocytotic
T737	303-317	CHEBI:33567	denotes	catecholamines
T738	471-477	SO:0000417	denotes	domain
T739	494-500	SO:0000417	denotes	domain
T740	524-528	CHEBI:29108	denotes	Ca2+
T741	534-546	CHEBI:16247	denotes	phospholipid
T742	571-577	SO:0000417	denotes	domain
T743	639-671	CHEBI:62643	denotes	negatively charged phospholipids
T744	701-710	CHEBI:29108	denotes	Ca2+ ions
T745	712-722	PR:000004080	denotes	Annexin A7
T746	839-859	GO:0000380	denotes	Alternative splicing
T747	878-886	SO:0001060	denotes	isoforms
T748	910-918	SO:0001060	denotes	isoforms
T749	952-956	SO:0000147	denotes	exon
T750	1002-1008	SO:0000417	denotes	domain
T751	1015-1022	UBERON:0000479	denotes	tissues
T752	1046-1053	SO:0001060	denotes	isoform
T753	1079-1084	UBERON:0000955	denotes	brain
T754	1089-1094	UBERON:0000948	denotes	heart
T755	1112-1119	SO:0001060	denotes	isoform
T756	1135-1144	GO:0010467	denotes	expressed
T757	1155-1163	UBERON:0004288	denotes	skeletal
T758	1194-1204	PR:000004080	denotes	annexin A7
T759	1228-1235	GO:0005829	denotes	cytosol
T760	1244-1259	GO:0005886	denotes	plasma membrane
T761	1272-1279	GO:0005634	denotes	nucleus
T762	1284-1293	GO:0031982	denotes	vesicular
T763	1315-1322	UBERON:0002369	denotes	adrenal
T764	1323-1342	GO:0042583	denotes	chromaffin granules
T765	1355-1363	GO:0030315	denotes	t-tubule
T766	1378-1388	PR:000004080	denotes	Annexin A7
T767	1405-1414	GO:0016020	denotes	membranes
T768	1420-1424	CHEBI:29108	denotes	Ca2+
T769	1453-1466	GO:0005622	denotes	intracellular
T770	1467-1471	CHEBI:29108	denotes	Ca2+
T771	1519-1525	_FRAGMENT	denotes	plasma
T772	1542-1550	GO:0005886	denotes	membrane
T773	1534-1550	GO:0031965	denotes	nuclear membrane
T774	1565-1578	GO:0005622	denotes	intracellular
T775	1579-1587	GO:0031982	denotes	vesicles
T776	1602-1612	PR:000004080	denotes	annexin A7
T777	1629-1634	CHEBI:18059	denotes	lipid
T778	1629-1640	GO:0045121	denotes	lipid rafts
T779	1646-1651	CHEBI:18059	denotes	Lipid
T780	1646-1657	GO:0045121	denotes	Lipid rafts
T781	1677-1685	GO:0016020	denotes	membrane
T782	1677-1693	GO:0006900	denotes	membrane budding
T783	1701-1713	GO:0006900	denotes	vesiculation
T785	1785-1795	PR:000004080	denotes	annexin A7
T786	1818-1824	PR:000015619	denotes	sorcin
T787	1829-1839	PR:000009771	denotes	galectin-3
T788	1849-1855	PR:000015619	denotes	Sorcin
T789	1861-1865	CHEBI:29108	denotes	Ca2+
T790	1941-1951	PR:000004080	denotes	annexin A7
T791	1964-1973	GO:0016020	denotes	membranes
T792	1979-1983	CHEBI:29108	denotes	Ca2+
T793	2002-2008	PR:000015619	denotes	Sorcin
T794	2063-2072	CHEBI:8925	denotes	ryanodine
T795	2098-2106	GO:0065007	denotes	modulate
T796	2147-2153	PR:000015619	denotes	sorcin
T797	2154-2164	PR:000004080	denotes	annexin A7
T798	2184-2193	CHEBI:8925	denotes	ryanodine
T799	2215-2221	PR:000015619	denotes	Sorcin
T800	2226-2236	PR:000004080	denotes	annexin A7
T801	2243-2252	GO:0010467	denotes	expressed
T802	2260-2267	UBERON:0000479	denotes	tissues
T803	2305-2315	PR:000004080	denotes	annexin A7
T804	2320-2326	PR:000015619	denotes	sorcin
T805	2330-2334	CHEBI:29108	denotes	Ca2+
T806	2370-2374	CHEBI:29108	denotes	Ca2+
T807	2395-2408	SO:0000409	denotes	binding sites
T808	2475-2481	PR:000015619	denotes	sorcin
T809	2529-2539	PR:000004080	denotes	annexin A7
T810	2601-2607	PR:000015619	denotes	sorcin
T811	2608-2617	CHEBI:36357	denotes	molecules
T812	2622-2632	PR:000004080	denotes	annexin A7
T813	2633-2641	CHEBI:36357	denotes	molecule
T814	2648-2658	PR:000009771	denotes	Galectin-3
T815	2743-2762	GO:0005615	denotes	extracellular space
T816	2771-2778	GO:0005634	denotes	nucleus
T817	2783-2792	GO:0005737	denotes	cytoplasm
T818	2800-2812	GO:0005739	denotes	mitochondria
T819	2814-2825	GO:0005737	denotes	Cytoplasmic
T820	2826-2836	PR:000009771	denotes	galectin-3
T821	2884-2897	GO:0005739	denotes	mitochondrial
T822	2928-2938	PR:000004080	denotes	annexin A7
T823	2948-2958	PR:000009771	denotes	galectin-3
T824	2980-3000	GO:0005640	denotes	perinuclear membrane
T825	3015-3025	PR:000009771	denotes	galectin-3
T826	3041-3051	PR:000004080	denotes	annexin A7
T827	3063-3073	PR:000009771	denotes	galectin-3
T828	3087-3107	GO:0042981	denotes	apoptosis regulation
T829	3113-3126	GO:0005739	denotes	mitochondrial
T830	3177-3187	PR:000004080	denotes	annexin A7
T831	3229-3237	GO:0065007	denotes	regulate
T832	3252-3268	GO:0044425	denotes	membrane domains
T833	3291-3295	CHEBI:29108	denotes	Ca2+
T834	3296-3307	GO:0042592	denotes	homeostasis
T835	3312-3316	CHEBI:29108	denotes	Ca2+
T836	3312-3345	GO:0019722	denotes	Ca2+-dependent signaling pathways
T837	3411-3421	PR:000004080	denotes	annexin A7
T838	3432-3437	NCBITaxon:10088	denotes	mouse
T839	3451-3461	PR:000004080	denotes	annexin A7
T840	3473-3477	NCBITaxon:10088	denotes	mice
T841	3601-3605	NCBITaxon:10088	denotes	mice
T842	3617-3624	PR:000045358	denotes	insulin
T843	3742-3749	PR:000045358	denotes	insulin
T844	3814-3828	CL:0000746	denotes	cardiomyocytes
T845	3916-3931	CL:0000232	denotes	red blood cells
T846	3920-3925	UBERON:0000178	denotes	blood
T847	3936-3945	CL:0000233	denotes	platelets
T848	3953-3958	PR:000004080	denotes	anxA7
T849	3981-3996	CL:0000232	denotes	red blood cells
T850	3985-3990	UBERON:0000178	denotes	blood
T851	4001-4010	CL:0000233	denotes	platelets
T852	4039-4049	PR:000004080	denotes	annexin A7
T853	4079-4086	SO:0001060	denotes	isoform
T854	4121-4136	CL:0000232	denotes	red blood cells
T855	4125-4130	UBERON:0000178	denotes	blood
T856	4142-4157	CL:0000232	denotes	Red blood cells
T857	4146-4151	UBERON:0000178	denotes	blood
T859	4282-4292	_FRAGMENT	denotes	release of
T860	4315-4326	GO:0006887	denotes	exovesicles
T861	4315-4326	GO:0070382	denotes	exovesicles
T862	4437-4451	CL:0000232	denotes	red blood cell
T863	4441-4446	UBERON:0000178	denotes	blood
T864	4508-4523	CL:0000232	denotes	Red blood cells
T865	4512-4517	UBERON:0000178	denotes	blood
T866	4550-4560	GO:0006900	denotes	vesiculate
T867	4582-4596	CL:0000232	denotes	red blood cell
T868	4586-4591	UBERON:0000178	denotes	blood
T869	4592-4608	GO:0008219	denotes	cell destruction
T870	4660-4668	GO:0031982	denotes	vesicles
T871	4670-4676	_FRAGMENT	denotes	micro-
T872	4685-4693	GO:1990742	denotes	vesicles
T873	4762-4773	CHEBI:16113	denotes	cholesterol
T874	4778-4790	CHEBI:26739	denotes	sphingolipid
T875	4796-4801	CHEBI:18059	denotes	lipid
T876	4796-4814	GO:0045121	denotes	lipid raft domains
T877	4876-4888	GO:0009986	denotes	cell surface
T878	4939-4944	CHEBI:18059	denotes	lipid
T879	4939-4949	GO:0045121	denotes	lipid raft
T880	4959-4967	PR:000015763	denotes	stomatin
T881	5001-5013	GO:0005856	denotes	cytoskeletal
T882	5053-5059	PR:000015619	denotes	sorcin
T883	5064-5074	PR:000004080	denotes	annexin A7
T884	5091-5096	CHEBI:18059	denotes	lipid
T885	5091-5102	GO:0045121	denotes	lipid rafts
T886	5143-5151	GO:0031982	denotes	vesicles
T887	5157-5164	GO:0031982	denotes	vesicle
T888	5157-5174	GO:0006900	denotes	vesicle formation
T889	5220-5234	CL:0000232	denotes	red blood cell
T890	5224-5229	UBERON:0000178	denotes	blood
T891	5240-5252	GO:0005856	denotes	cytoskeletal
T892	5287-5299	CHEBI:16247	denotes	phospholipid
T893	5319-5336	GO:0005886	denotes	cellular membrane
T727	27-31	CHEBI:29108	denotes	Ca2+
T784	1742-1752	GO:0006887	denotes	exocytosis
T858	4229-4233	CHEBI:29108	denotes	Ca2+
R306	T731	T730	_lexicallyChainedTo	membranes,fusion of
R307	T772	T771	_lexicallyChainedTo	membrane,plasma
R308	T860	T859	_lexicallyChainedTo	exovesicles,release of
R309	T872	T871	_lexicallyChainedTo	vesicles,micro-

2_test

Id	Subject	Object	Predicate	Lexical cue
12925238-632306-8102376	319-320	632306	denotes	1
12925238-8155692-8102377	618-619	8155692	denotes	2
12925238-9223619-8102377	618-619	9223619	denotes	2
12925238-11917092-8102377	618-619	11917092	denotes	2
12925238-7738119-8102378	1372-1373	7738119	denotes	5
12925238-11338180-8102379	1374-1375	11338180	denotes	6
12925238-11895795-8102380	1642-1643	11895795	denotes	7
12925238-11454455-8102381	1754-1755	11454455	denotes	8
12925238-11454454-8102381	1754-1755	11454454	denotes	8
12925238-11152672-8102381	1754-1755	11152672	denotes	8
12925238-9268363-8102382	1841-1843	9268363	denotes	11
12925238-10767422-8102382	1841-1843	10767422	denotes	11
12925238-11839755-8102382	1841-1843	11839755	denotes	11
12925238-9441591-8102383	1931-1933	9441591	denotes	14
12925238-7592856-8102384	2121-2123	7592856	denotes	15
12925238-9268363-8102385	2285-2287	9268363	denotes	11
12925238-10767422-8102386	2643-2645	10767422	denotes	12
12925238-11839755-8102387	3151-3153	11839755	denotes	13
12925238-10570150-8102388	3573-3575	10570150	denotes	16
12925238-11390641-8102389	3705-3707	11390641	denotes	17
12925238-11895795-8102390	4138-4139	11895795	denotes	7
12925238-8702518-8102391	4255-4257	8702518	denotes	18
12925238-10733516-8102392	4258-4260	10733516	denotes	19
12925238-11895795-8102393	4366-4367	11895795	denotes	7
12925238-6781476-8102394	4368-4370	6781476	denotes	20
12925238-7678519-8102395	4630-4632	7678519	denotes	21
12925238-11895795-8102396	5023-5024	11895795	denotes	7

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T895	27-31	CHEBI:29108	denotes	Ca2+
T896	37-49	CHEBI:16247	denotes	phospholipid
T897	50-57	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T898	58-65	CHEBI_PR_EXT:protein	denotes	protein
T899	128-147	GO:0042583	denotes	chromaffin granules
T900	152-161	_FRAGMENT	denotes	fusion of
T901	175-184	GO:0061025	denotes	membranes
T902	162-174	CHEBI:16247	denotes	phospholipid
T903	175-184	GO:0016020	denotes	membranes
T904	204-208	CHEBI:29108	denotes	Ca2+
T905	247-257	PR_EXT:000004080	denotes	annexin A7
T906	279-289	GO:0006887	denotes	exocytotic
T907	290-299	GO_EXT:secretion_entity_or_process	denotes	secretion
T908	303-317	CHEBI:33567	denotes	catecholamines
T909	327-334	CHEBI_PR_EXT:protein	denotes	protein
T910	358-382	SO_EXT:biological_conservation_process_or_quality	denotes	evolutionarily conserved
T911	383-391	CHEBI_PR_EXT:protein	denotes	proteins
T912	433-443	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T913	450-459	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T914	460-470	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T915	471-477	SO_EXT:0000417	denotes	domain
T916	483-493	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T917	494-500	SO_EXT:0000417	denotes	domain
T918	524-528	CHEBI:29108	denotes	Ca2+
T919	534-546	CHEBI:16247	denotes	phospholipid
T920	547-554	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T921	560-570	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T922	571-577	SO_EXT:0000417	denotes	domain
T923	628-635	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T924	639-671	CHEBI:62643	denotes	negatively charged phospholipids
T925	701-710	CHEBI:29108	denotes	Ca2+ ions
T926	712-722	PR_EXT:000004080	denotes	Annexin A7
T927	792-806	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	amino terminus
T928	826-837	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T929	839-859	GO:0000380	denotes	Alternative splicing
T930	878-886	SO_EXT:0001060	denotes	isoforms
T931	910-918	SO_EXT:0001060	denotes	isoforms
T932	952-956	SO_EXT:0000147	denotes	exon
T933	991-1001	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T934	1002-1008	SO_EXT:0000417	denotes	domain
T935	1015-1022	UBERON:0000479	denotes	tissues
T936	1046-1053	SO_EXT:0001060	denotes	isoform
T937	1079-1084	UBERON:0000955	denotes	brain
T938	1089-1094	UBERON:0000948	denotes	heart
T939	1112-1119	SO_EXT:0001060	denotes	isoform
T940	1135-1144	GO:0010467	denotes	expressed
T941	1155-1170	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T942	1179-1187	CL_GO_EXT:cell	denotes	cellular
T943	1194-1204	PR_EXT:000004080	denotes	annexin A7
T944	1228-1235	GO:0005829	denotes	cytosol
T945	1244-1259	GO:0005886	denotes	plasma membrane
T946	1272-1279	GO:0005634	denotes	nucleus
T947	1284-1293	GO:0031982	denotes	vesicular
T948	1315-1322	UBERON:0002369	denotes	adrenal
T949	1323-1342	GO:0042583	denotes	chromaffin granules
T950	1355-1363	GO:0030315	denotes	t-tubule
T951	1378-1388	PR_EXT:000004080	denotes	Annexin A7
T952	1389-1401	GO_EXT:biological_movement_or_translocation_process	denotes	translocates
T953	1405-1414	GO:0016020	denotes	membranes
T954	1420-1424	CHEBI:29108	denotes	Ca2+
T955	1453-1466	GO:0005622	denotes	intracellular
T956	1458-1466	CL_GO_EXT:cell	denotes	cellular
T957	1467-1471	CHEBI:29108	denotes	Ca2+
T958	1519-1525	_FRAGMENT	denotes	plasma
T959	1542-1550	GO:0005886	denotes	membrane
T960	1534-1550	GO:0031965	denotes	nuclear membrane
T961	1565-1578	GO:0005622	denotes	intracellular
T962	1570-1578	CL_GO_EXT:cell	denotes	cellular
T963	1579-1587	GO:0031982	denotes	vesicles
T964	1602-1612	PR_EXT:000004080	denotes	annexin A7
T965	1629-1634	CHEBI:18059	denotes	lipid
T966	1629-1640	GO:0045121	denotes	lipid rafts
T967	1646-1651	CHEBI:18059	denotes	Lipid
T968	1646-1657	GO:0045121	denotes	Lipid rafts
T969	1677-1685	GO:0016020	denotes	membrane
T970	1677-1693	GO:0006900	denotes	membrane budding
T971	1701-1713	GO:0006900	denotes	vesiculation
T972	1742-1752	GO:0006887	denotes	exocytosis
T973	1765-1772	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T974	1785-1795	PR_EXT:000004080	denotes	annexin A7
T975	1818-1824	PR_EXT:000015619	denotes	sorcin
T976	1829-1839	PR_EXT:000009771	denotes	galectin-3
T977	1849-1855	PR_EXT:000015619	denotes	Sorcin
T978	1861-1865	CHEBI:29108	denotes	Ca2+
T979	1866-1873	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T980	1874-1881	CHEBI_PR_EXT:protein	denotes	protein
T981	1915-1922	CHEBI_PR_EXT:protein	denotes	protein
T982	1941-1951	PR_EXT:000004080	denotes	annexin A7
T983	1955-1960	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T984	1964-1973	GO:0016020	denotes	membranes
T985	1979-1983	CHEBI:29108	denotes	Ca2+
T986	2002-2008	PR_EXT:000015619	denotes	Sorcin
T987	2063-2072	CHEBI:8925	denotes	ryanodine
T988	2073-2081	GO_EXT:0004872	denotes	receptor
T989	2098-2106	GO:0065007	denotes	modulate
T990	2147-2153	PR_EXT:000015619	denotes	sorcin
T991	2154-2164	PR_EXT:000004080	denotes	annexin A7
T992	2184-2193	CHEBI:8925	denotes	ryanodine
T993	2194-2202	GO_EXT:0004872	denotes	receptor
T994	2215-2221	PR_EXT:000015619	denotes	Sorcin
T995	2226-2236	PR_EXT:000004080	denotes	annexin A7
T996	2243-2252	GO:0010467	denotes	expressed
T997	2260-2267	UBERON:0000479	denotes	tissues
T998	2294-2301	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T999	2305-2315	PR_EXT:000004080	denotes	annexin A7
T1000	2320-2326	PR_EXT:000015619	denotes	sorcin
T1001	2330-2334	CHEBI:29108	denotes	Ca2+
T1002	2370-2374	CHEBI:29108	denotes	Ca2+
T1003	2395-2402	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T1004	2395-2408	SO_EXT:0000409	denotes	binding sites
T1005	2436-2450	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	amino terminal
T1006	2465-2471	SO_EXT:sequence_or_structure_motif	denotes	motifs
T1007	2475-2481	PR_EXT:000015619	denotes	sorcin
T1008	2498-2503	SO_EXT:sequence_or_structure_motif	denotes	motif
T1009	2511-2525	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	amino terminus
T1010	2529-2539	PR_EXT:000004080	denotes	annexin A7
T1011	2545-2553	CHEBI_PR_EXT:protein	denotes	proteins
T1012	2554-2558	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T1013	2601-2607	PR_EXT:000015619	denotes	sorcin
T1014	2608-2617	CHEBI:36357	denotes	molecules
T1015	2622-2632	PR_EXT:000004080	denotes	annexin A7
T1016	2633-2641	CHEBI:36357	denotes	molecule
T1017	2648-2658	PR_EXT:000009771	denotes	Galectin-3
T1018	2690-2697	CHEBI_PR_EXT:protein	denotes	protein
T1019	2711-2720	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T1020	2743-2762	GO:0005615	denotes	extracellular space
T1021	2748-2756	CL_GO_EXT:cell	denotes	cellular
T1022	2771-2778	GO:0005634	denotes	nucleus
T1023	2783-2792	GO:0005737	denotes	cytoplasm
T1024	2800-2812	GO:0005739	denotes	mitochondria
T1025	2814-2825	GO:0005737	denotes	Cytoplasmic
T1026	2826-2836	PR_EXT:000009771	denotes	galectin-3
T1027	2884-2897	GO:0005739	denotes	mitochondrial
T1028	2909-2924	GO_EXT:negative_regulation	denotes	Down regulation
T1029	2928-2938	PR_EXT:000004080	denotes	annexin A7
T1030	2948-2958	PR_EXT:000009771	denotes	galectin-3
T1031	2959-2972	GO_EXT:biological_translocation_entity_or_process	denotes	translocation
T1032	2980-3000	GO:0005640	denotes	perinuclear membrane
T1033	3015-3025	PR_EXT:000009771	denotes	galectin-3
T1034	3026-3035	GO_EXT:secretion_entity_or_process	denotes	secretion
T1035	3041-3051	PR_EXT:000004080	denotes	annexin A7
T1036	3063-3073	PR_EXT:000009771	denotes	galectin-3
T1037	3074-3085	GO_EXT:biological_routing_or_transport	denotes	trafficking
T1038	3087-3107	GO:0042981	denotes	apoptosis regulation
T1039	3113-3126	GO:0005739	denotes	mitochondrial
T1040	3160-3168	CL_GO_EXT:cell	denotes	cellular
T1041	3177-3187	PR_EXT:000004080	denotes	annexin A7
T1042	3229-3237	GO:0065007	denotes	regulate
T1043	3252-3268	GO:0044425	denotes	membrane domains
T1044	3291-3295	CHEBI:29108	denotes	Ca2+
T1045	3296-3307	GO:0042592	denotes	homeostasis
T1046	3312-3316	CHEBI:29108	denotes	Ca2+
T1047	3312-3345	GO:0019722	denotes	Ca2+-dependent signaling pathways
T1048	3411-3421	PR_EXT:000004080	denotes	annexin A7
T1049	3432-3437	NCBITaxon:10088	denotes	mouse
T1050	3438-3445	SO_EXT:sequence_altered_entity	denotes	mutants
T1051	3451-3461	PR_EXT:000004080	denotes	annexin A7
T1052	3468-3472	SO_EXT:sequence_nullness	denotes	null
T1053	3473-3477	NCBITaxon:10088	denotes	mice
T1054	3580-3586	GO_EXT:fatality_or_lethality	denotes	lethal
T1055	3601-3605	NCBITaxon:10088	denotes	mice
T1056	3617-3624	PR_EXT:000045358	denotes	insulin
T1057	3625-3634	GO_EXT:secretion_entity_or_process	denotes	secretion
T1058	3668-3672	SO_EXT:sequence_nullness	denotes	null
T1059	3742-3749	PR_EXT:000045358	denotes	insulin
T1060	3750-3759	GO_EXT:secretion_entity_or_process	denotes	secretion
T1061	3814-3828	CL:0000746	denotes	cardiomyocytes
T1062	3916-3931	CL:0000232	denotes	red blood cells
T1063	3920-3925	UBERON:0000178	denotes	blood
T1064	3926-3931	CL_GO_EXT:cell	denotes	cells
T1065	3936-3945	CL:0000233	denotes	platelets
T1066	3953-3958	PR_EXT:000004080	denotes	anxA7
T1067	3958-3959	SO_EXT:sequence_nullness_or_absence	denotes	-
T1068	3960-3961	SO_EXT:sequence_nullness_or_absence	denotes	-
T1069	3962-3968	SO_EXT:sequence_altered_entity	denotes	mutant
T1070	3981-3996	CL:0000232	denotes	red blood cells
T1071	3985-3990	UBERON:0000178	denotes	blood
T1072	3991-3996	CL_GO_EXT:cell	denotes	cells
T1073	4001-4010	CL:0000233	denotes	platelets
T1074	4039-4049	PR_EXT:000004080	denotes	annexin A7
T1075	4079-4086	SO_EXT:0001060	denotes	isoform
T1076	4121-4136	CL:0000232	denotes	red blood cells
T1077	4125-4130	UBERON:0000178	denotes	blood
T1078	4131-4136	CL_GO_EXT:cell	denotes	cells
T1079	4142-4157	CL:0000232	denotes	Red blood cells
T1080	4146-4151	UBERON:0000178	denotes	blood
T1081	4152-4157	CL_GO_EXT:cell	denotes	cells
T1082	4174-4185	CHEBI_EXT:biochemical	denotes	biochemical
T1083	4229-4233	CHEBI:29108	denotes	Ca2+
T1084	4282-4292	_FRAGMENT	denotes	release of
T1085	4315-4326	GO:0006887	denotes	exovesicles
T1086	4293-4303	CHEBI_GO_EXT:hemoglobin	denotes	hemoglobin
T1087	4315-4326	GO:0070382	denotes	exovesicles
T1088	4437-4451	CL:0000232	denotes	red blood cell
T1089	4441-4446	UBERON:0000178	denotes	blood
T1090	4447-4451	CL_GO_EXT:cell	denotes	cell
T1091	4508-4523	CL:0000232	denotes	Red blood cells
T1092	4512-4517	UBERON:0000178	denotes	blood
T1093	4518-4523	CL_GO_EXT:cell	denotes	cells
T1094	4550-4560	GO:0006900	denotes	vesiculate
T1095	4582-4596	CL:0000232	denotes	red blood cell
T1096	4586-4591	UBERON:0000178	denotes	blood
T1097	4592-4596	CL_GO_EXT:cell	denotes	cell
T1098	4592-4608	GO:0008219	denotes	cell destruction
T1099	4660-4668	GO:0031982	denotes	vesicles
T1100	4670-4676	_FRAGMENT	denotes	micro-
T1101	4685-4693	GO:1990742	denotes	vesicles
T1102	4762-4773	CHEBI:16113	denotes	cholesterol
T1103	4778-4790	CHEBI:26739	denotes	sphingolipid
T1104	4796-4801	CHEBI:18059	denotes	lipid
T1105	4796-4814	GO:0045121	denotes	lipid raft domains
T1106	4840-4848	CHEBI_PR_EXT:protein	denotes	proteins
T1107	4854-4874	GO_PR_EXT:acetylcholinesterase	denotes	acetylcholinesterase
T1108	4876-4880	CL_GO_EXT:cell	denotes	cell
T1109	4876-4888	GO:0009986	denotes	cell surface
T1110	4889-4897	CHEBI_PR_EXT:protein	denotes	proteins
T1111	4910-4929	GO_EXT:0004875	denotes	complement receptor
T1112	4939-4944	CHEBI:18059	denotes	lipid
T1113	4939-4949	GO:0045121	denotes	lipid raft
T1114	4950-4958	CHEBI_PR_EXT:protein	denotes	proteins
T1115	4959-4967	PR_EXT:000015763	denotes	stomatin
T1116	4972-4981	PR_EXT:flotillin	denotes	flotillin
T1117	5001-5013	GO:0005856	denotes	cytoskeletal
T1118	5014-5021	CHEBI_PR_EXT:protein	denotes	protein
T1119	5053-5059	PR_EXT:000015619	denotes	sorcin
T1120	5064-5074	PR_EXT:000004080	denotes	annexin A7
T1121	5091-5096	CHEBI:18059	denotes	lipid
T1122	5091-5102	GO:0045121	denotes	lipid rafts
T1123	5109-5117	CHEBI_PR_EXT:protein	denotes	proteins
T1124	5143-5151	GO:0031982	denotes	vesicles
T1125	5157-5164	GO:0031982	denotes	vesicle
T1126	5157-5174	GO:0006900	denotes	vesicle formation
T1127	5220-5234	CL:0000232	denotes	red blood cell
T1128	5224-5229	UBERON:0000178	denotes	blood
T1129	5230-5234	CL_GO_EXT:cell	denotes	cell
T1130	5240-5252	GO:0005856	denotes	cytoskeletal
T1131	5287-5299	CHEBI:16247	denotes	phospholipid
T1132	5319-5327	CL_GO_EXT:cell	denotes	cellular
T1133	5319-5336	GO:0005886	denotes	cellular membrane
T894	11-21	PR_EXT:000004080	denotes	Annexin A7
R310	T901	T900	_lexicallyChainedTo	membranes,fusion of
R311	T959	T958	_lexicallyChainedTo	membrane,plasma
R312	T1085	T1084	_lexicallyChainedTo	exovesicles,release of
R313	T1101	T1100	_lexicallyChainedTo	vesicles,micro-

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