PMC:194730 / 1832-36179 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1135	19-21	NN	denotes	A7
T1136	22-24	VBZ	denotes	is
T1137	25-26	DT	denotes	a
T1138	58-65	NN	denotes	protein
T1139	27-31	NN	denotes	Ca2+
T1140	50-57	VBG	denotes	binding
T1141	31-32	HYPH	denotes	-
T1142	33-36	CC	denotes	and
T1143	37-49	NN	denotes	phospholipid
T1144	49-50	HYPH	denotes	-
T1145	65-67	,	denotes	,
T1146	67-72	WDT	denotes	which
T1147	77-85	VBN	denotes	isolated
T1148	73-76	VBD	denotes	was
T1149	86-88	IN	denotes	as
T1150	89-92	DT	denotes	the
T1151	93-98	NN	denotes	agent
T1152	99-103	WDT	denotes	that
T1153	104-112	VBD	denotes	mediated
T1154	113-124	NN	denotes	aggregation
T1155	125-127	IN	denotes	of
T1156	128-138	NN	denotes	chromaffin
T1157	139-147	NNS	denotes	granules
T1158	148-151	CC	denotes	and
T1159	152-158	NN	denotes	fusion
T1160	159-161	IN	denotes	of
T1161	162-174	NN	denotes	phospholipid
T1162	175-184	NNS	denotes	membranes
T1163	185-187	IN	denotes	in
T1164	188-191	DT	denotes	the
T1165	192-200	NN	denotes	presence
T1166	201-203	IN	denotes	of
T1167	204-208	NN	denotes	Ca2+
T1168	208-209	.	denotes	.
T1169	209-322	sentence	denotes	This activity led to the proposal of annexin A7's involvement in the exocytotic secretion of catecholamines [1].
T1170	210-214	DT	denotes	This
T1171	215-223	NN	denotes	activity
T1172	224-227	VBD	denotes	led
T1173	228-230	IN	denotes	to
T1174	231-234	DT	denotes	the
T1175	235-243	NN	denotes	proposal
T1176	244-246	IN	denotes	of
T1177	247-254	NN	denotes	annexin
T1178	255-257	NN	denotes	A7
T1179	260-271	NN	denotes	involvement
T1180	257-259	POS	denotes	's
T1181	272-274	IN	denotes	in
T1182	275-278	DT	denotes	the
T1183	290-299	NN	denotes	secretion
T1184	279-289	JJ	denotes	exocytotic
T1185	300-302	IN	denotes	of
T1186	303-317	NNS	denotes	catecholamines
T1187	318-319	-LRB-	denotes	[
T1188	319-320	CD	denotes	1
T1189	320-321	-RRB-	denotes	]
T1190	321-322	.	denotes	.
T1191	322-478	sentence	denotes	The protein belongs to a family of evolutionarily conserved proteins of a bipartite structure with a variable N-terminal and a conserved C-terminal domain.
T1192	323-326	DT	denotes	The
T1193	327-334	NN	denotes	protein
T1194	335-342	VBZ	denotes	belongs
T1195	343-345	IN	denotes	to
T1196	346-347	DT	denotes	a
T1197	348-354	NN	denotes	family
T1198	355-357	IN	denotes	of
T1199	358-372	RB	denotes	evolutionarily
T1200	373-382	VBN	denotes	conserved
T1201	383-391	NN	denotes	proteins
T1202	392-394	IN	denotes	of
T1203	395-396	DT	denotes	a
T1204	407-416	NN	denotes	structure
T1205	397-406	JJ	denotes	bipartite
T1206	417-421	IN	denotes	with
T1207	422-423	DT	denotes	a
T1208	424-432	JJ	denotes	variable
T1209	433-434	NN	denotes	N
T1210	435-443	JJ	denotes	terminal
T1211	434-435	HYPH	denotes	-
T1212	444-447	CC	denotes	and
T1213	448-449	DT	denotes	a
T1214	450-459	VBN	denotes	conserved
T1215	460-461	NN	denotes	C
T1216	462-470	JJ	denotes	terminal
T1217	461-462	HYPH	denotes	-
T1218	471-477	NN	denotes	domain
T1219	477-478	.	denotes	.
T1220	478-623	sentence	denotes	The C-terminal domain is responsible for the Ca2+- and phospholipid-binding, the N-terminal domain appears to confer functional diversity [2-4].
T1221	479-482	DT	denotes	The
T1222	494-500	NN	denotes	domain
T1223	483-484	NN	denotes	C
T1224	485-493	JJ	denotes	terminal
T1225	484-485	HYPH	denotes	-
T1226	501-503	VBZ	denotes	is
T1227	578-585	VBZ	denotes	appears
T1228	504-515	JJ	denotes	responsible
T1229	516-519	IN	denotes	for
T1230	520-523	DT	denotes	the
T1231	524-528	NN	denotes	Ca2+
T1232	528-529	HYPH	denotes	-
T1233	530-533	CC	denotes	and
T1234	534-546	NN	denotes	phospholipid
T1235	546-547	HYPH	denotes	-
T1236	547-554	VBG	denotes	binding
T1237	554-556	,	denotes	,
T1238	556-559	DT	denotes	the
T1239	571-577	NN	denotes	domain
T1240	560-561	NN	denotes	N
T1241	562-570	JJ	denotes	terminal
T1242	561-562	HYPH	denotes	-
T1243	586-588	TO	denotes	to
T1244	589-595	VB	denotes	confer
T1245	596-606	JJ	denotes	functional
T1246	607-616	NN	denotes	diversity
T1247	617-618	-LRB-	denotes	[
T1248	618-619	CD	denotes	2
T1249	619-620	SYM	denotes	-
T1250	620-621	CD	denotes	4
T1251	621-622	-RRB-	denotes	]
T1252	622-623	.	denotes	.
T1253	623-711	sentence	denotes	The binding to negatively charged phospholipids is thought to be mediated by Ca2+ ions.
T1254	624-627	DT	denotes	The
T1255	628-635	NN	denotes	binding
T1256	675-682	VBN	denotes	thought
T1257	636-638	IN	denotes	to
T1258	639-649	RB	denotes	negatively
T1259	650-657	JJ	denotes	charged
T1260	658-671	NNS	denotes	phospholipids
T1261	672-674	VBZ	denotes	is
T1262	683-685	TO	denotes	to
T1263	689-697	VBN	denotes	mediated
T1264	686-688	VB	denotes	be
T1265	698-700	IN	denotes	by
T1266	701-705	NN	denotes	Ca2+
T1267	706-710	NNS	denotes	ions
T1268	710-711	.	denotes	.
T1269	711-838	sentence	denotes	Annexin A7 is unique in that it carries an extraordinarily long and hydrophobic amino terminus with more than 100 amino acids.
T1270	712-719	NN	denotes	Annexin
T1271	720-722	NN	denotes	A7
T1272	723-725	VBZ	denotes	is
T1273	726-732	JJ	denotes	unique
T1274	733-735	IN	denotes	in
T1275	744-751	VBZ	denotes	carries
T1276	736-740	IN	denotes	that
T1277	741-743	PRP	denotes	it
T1278	752-754	DT	denotes	an
T1279	798-806	NN	denotes	terminus
T1280	755-770	RB	denotes	extraordinarily
T1281	771-775	JJ	denotes	long
T1282	776-779	CC	denotes	and
T1283	780-791	JJ	denotes	hydrophobic
T1284	792-797	NN	denotes	amino
T1285	807-811	IN	denotes	with
T1286	812-816	JJR	denotes	more
T1287	822-825	CD	denotes	100
T1288	817-821	IN	denotes	than
T1289	832-837	NNS	denotes	acids
T1290	826-831	NN	denotes	amino
T1291	837-838	.	denotes	.
T1292	838-904	sentence	denotes	Alternative splicing gives rise to two isoforms of 47 and 51 kDa.
T1293	839-850	JJ	denotes	Alternative
T1294	851-859	NN	denotes	splicing
T1295	860-865	VBZ	denotes	gives
T1296	866-870	NN	denotes	rise
T1297	871-873	IN	denotes	to
T1298	874-877	CD	denotes	two
T1299	878-886	NNS	denotes	isoforms
T1300	887-889	IN	denotes	of
T1301	890-892	CD	denotes	47
T1302	900-903	NN	denotes	kDa
T1303	893-896	CC	denotes	and
T1304	897-899	CD	denotes	51
T1305	903-904	.	denotes	.
T1306	904-1009	sentence	denotes	Both isoforms differ by an additional cassette exon located in the first third of the N-terminal domain.
T1307	905-909	DT	denotes	Both
T1308	910-918	NNS	denotes	isoforms
T1309	919-925	VBP	denotes	differ
T1310	926-928	IN	denotes	by
T1311	929-931	DT	denotes	an
T1312	952-956	NN	denotes	exon
T1313	932-942	JJ	denotes	additional
T1314	943-951	NN	denotes	cassette
T1315	957-964	JJ	denotes	located
T1316	965-967	IN	denotes	in
T1317	968-971	DT	denotes	the
T1318	978-983	NN	denotes	third
T1319	972-977	JJ	denotes	first
T1320	984-986	IN	denotes	of
T1321	987-990	DT	denotes	the
T1322	1002-1008	NN	denotes	domain
T1323	991-992	NN	denotes	N
T1324	993-1001	JJ	denotes	terminal
T1325	992-993	HYPH	denotes	-
T1326	1008-1009	.	denotes	.
T1327	1009-1171	sentence	denotes	Most tissues harbor only the 47 kDa isoform, both forms are found in brain and heart, while the large isoform is exclusively expressed in mature skeletal muscle.
T1328	1010-1014	JJS	denotes	Most
T1329	1015-1022	NNS	denotes	tissues
T1330	1023-1029	VBP	denotes	harbor
T1331	1070-1075	VBN	denotes	found
T1332	1030-1034	RB	denotes	only
T1333	1046-1053	NN	denotes	isoform
T1334	1035-1038	DT	denotes	the
T1335	1039-1041	CD	denotes	47
T1336	1042-1045	NN	denotes	kDa
T1337	1053-1055	,	denotes	,
T1338	1055-1059	DT	denotes	both
T1339	1060-1065	NNS	denotes	forms
T1340	1066-1069	VBP	denotes	are
T1341	1076-1078	IN	denotes	in
T1342	1079-1084	NN	denotes	brain
T1343	1085-1088	CC	denotes	and
T1344	1089-1094	NN	denotes	heart
T1345	1094-1096	,	denotes	,
T1346	1096-1101	IN	denotes	while
T1347	1135-1144	VBN	denotes	expressed
T1348	1102-1105	DT	denotes	the
T1349	1112-1119	NN	denotes	isoform
T1350	1106-1111	JJ	denotes	large
T1351	1120-1122	VBZ	denotes	is
T1352	1123-1134	RB	denotes	exclusively
T1353	1145-1147	IN	denotes	in
T1354	1148-1154	JJ	denotes	mature
T1355	1164-1170	NN	denotes	muscle
T1356	1155-1163	JJ	denotes	skeletal
T1357	1170-1171	.	denotes	.
T1358	1171-1377	sentence	denotes	At the cellular level annexin A7 can be detected in the cytosol, at the plasma membrane, around the nucleus, at vesicular structures including adrenal chromaffin granules, and at the t-tubule system [5,6].
T1359	1172-1174	IN	denotes	At
T1360	1212-1220	VBN	denotes	detected
T1361	1175-1178	DT	denotes	the
T1362	1188-1193	NN	denotes	level
T1363	1179-1187	JJ	denotes	cellular
T1364	1194-1201	NN	denotes	annexin
T1365	1202-1204	NN	denotes	A7
T1366	1205-1208	MD	denotes	can
T1367	1209-1211	VB	denotes	be
T1368	1221-1223	IN	denotes	in
T1369	1224-1227	DT	denotes	the
T1370	1228-1235	NN	denotes	cytosol
T1371	1235-1237	,	denotes	,
T1372	1237-1239	IN	denotes	at
T1373	1240-1243	DT	denotes	the
T1374	1251-1259	NN	denotes	membrane
T1375	1244-1250	NN	denotes	plasma
T1376	1259-1261	,	denotes	,
T1377	1261-1267	IN	denotes	around
T1378	1268-1271	DT	denotes	the
T1379	1272-1279	NN	denotes	nucleus
T1380	1279-1281	,	denotes	,
T1381	1281-1283	IN	denotes	at
T1382	1284-1293	JJ	denotes	vesicular
T1383	1294-1304	NNS	denotes	structures
T1384	1305-1314	VBG	denotes	including
T1385	1315-1322	JJ	denotes	adrenal
T1386	1334-1342	NNS	denotes	granules
T1387	1323-1333	NN	denotes	chromaffin
T1388	1342-1344	,	denotes	,
T1389	1344-1347	CC	denotes	and
T1390	1348-1350	IN	denotes	at
T1391	1351-1354	DT	denotes	the
T1392	1364-1370	NN	denotes	system
T1393	1355-1356	NN	denotes	t
T1394	1357-1363	NN	denotes	tubule
T1395	1356-1357	HYPH	denotes	-
T1396	1371-1372	-LRB-	denotes	[
T1397	1374-1375	CD	denotes	6
T1398	1372-1373	CD	denotes	5
T1399	1373-1374	,	denotes	,
T1400	1375-1376	-RRB-	denotes	]
T1401	1376-1377	.	denotes	.
T1402	1377-1588	sentence	denotes	Annexin A7 translocates to membranes in a Ca2+-dependent fashion and, when intracellular Ca2+ levels rise, sequentially redistributes to the plasma and the nuclear membrane as well as to intracellular vesicles.
T1403	1378-1385	NN	denotes	Annexin
T1404	1386-1388	NN	denotes	A7
T1405	1389-1401	VBZ	denotes	translocates
T1406	1402-1404	IN	denotes	to
T1407	1405-1414	NNS	denotes	membranes
T1408	1415-1417	IN	denotes	in
T1409	1418-1419	DT	denotes	a
T1410	1435-1442	NN	denotes	fashion
T1411	1420-1424	NN	denotes	Ca2+
T1412	1425-1434	JJ	denotes	dependent
T1413	1424-1425	HYPH	denotes	-
T1414	1443-1446	CC	denotes	and
T1415	1446-1448	,	denotes	,
T1416	1498-1511	VBZ	denotes	redistributes
T1417	1448-1452	WRB	denotes	when
T1418	1479-1483	VBP	denotes	rise
T1419	1453-1466	JJ	denotes	intracellular
T1420	1472-1478	NNS	denotes	levels
T1421	1467-1471	NN	denotes	Ca2+
T1422	1483-1485	,	denotes	,
T1423	1485-1497	RB	denotes	sequentially
T1424	1512-1514	IN	denotes	to
T1425	1515-1518	DT	denotes	the
T1426	1519-1525	NN	denotes	plasma
T1427	1526-1529	CC	denotes	and
T1428	1530-1533	DT	denotes	the
T1429	1542-1550	NN	denotes	membrane
T1430	1534-1541	JJ	denotes	nuclear
T1431	1551-1553	RB	denotes	as
T1432	1559-1561	IN	denotes	as
T1433	1554-1558	RB	denotes	well
T1434	1562-1564	IN	denotes	to
T1435	1565-1578	JJ	denotes	intracellular
T1436	1579-1587	NNS	denotes	vesicles
T1437	1587-1588	.	denotes	.
T1438	1588-1645	sentence	denotes	Furthermore, annexin A7 associates with lipid rafts [7].
T1439	1589-1600	RB	denotes	Furthermore
T1440	1613-1623	VBZ	denotes	associates
T1441	1600-1602	,	denotes	,
T1442	1602-1609	NN	denotes	annexin
T1443	1610-1612	NN	denotes	A7
T1444	1624-1628	IN	denotes	with
T1445	1629-1634	NN	denotes	lipid
T1446	1635-1640	NNS	denotes	rafts
T1447	1641-1642	-LRB-	denotes	[
T1448	1642-1643	CD	denotes	7
T1449	1643-1644	-RRB-	denotes	]
T1450	1644-1645	.	denotes	.
T1451	1645-1760	sentence	denotes	Lipid rafts play a key role in membrane budding and in vesiculation processes such as endo- and exocytosis [8-10].
T1452	1646-1651	NN	denotes	Lipid
T1453	1652-1657	NNS	denotes	rafts
T1454	1658-1662	VBP	denotes	play
T1455	1663-1664	DT	denotes	a
T1456	1669-1673	NN	denotes	role
T1457	1665-1668	JJ	denotes	key
T1458	1674-1676	IN	denotes	in
T1459	1677-1685	NN	denotes	membrane
T1460	1686-1693	NN	denotes	budding
T1461	1694-1697	CC	denotes	and
T1462	1698-1700	IN	denotes	in
T1463	1701-1713	NN	denotes	vesiculation
T1464	1714-1723	NNS	denotes	processes
T1465	1724-1728	JJ	denotes	such
T1466	1729-1731	IN	denotes	as
T1467	1732-1736	AFX	denotes	endo
T1468	1742-1752	NN	denotes	exocytosis
T1469	1736-1737	HYPH	denotes	-
T1470	1738-1741	CC	denotes	and
T1471	1753-1754	-LRB-	denotes	[
T1472	1754-1755	CD	denotes	8
T1473	1755-1756	SYM	denotes	-
T1474	1756-1758	CD	denotes	10
T1475	1758-1759	-RRB-	denotes	]
T1476	1759-1760	.	denotes	.
T1477	1760-1848	sentence	denotes	Two binding partners of annexin A7 have been identified, sorcin and galectin-3 [11-13].
T1478	1761-1764	CD	denotes	Two
T1479	1773-1781	NNS	denotes	partners
T1480	1765-1772	VBG	denotes	binding
T1481	1806-1816	VBN	denotes	identified
T1482	1782-1784	IN	denotes	of
T1483	1785-1792	NN	denotes	annexin
T1484	1793-1795	NN	denotes	A7
T1485	1796-1800	VBP	denotes	have
T1486	1801-1805	VBN	denotes	been
T1487	1816-1818	,	denotes	,
T1488	1818-1824	NN	denotes	sorcin
T1489	1825-1828	CC	denotes	and
T1490	1829-1837	NN	denotes	galectin
T1491	1837-1838	HYPH	denotes	-
T1492	1838-1839	CD	denotes	3
T1493	1840-1841	-LRB-	denotes	[
T1494	1841-1843	CD	denotes	11
T1495	1843-1844	SYM	denotes	-
T1496	1844-1846	CD	denotes	13
T1497	1846-1847	-RRB-	denotes	]
T1498	1847-1848	.	denotes	.
T1499	1848-1935	sentence	denotes	Sorcin is a Ca2+-binding protein and belongs to the penta EF-hand protein family [14].
T1500	1849-1855	NN	denotes	Sorcin
T1501	1856-1858	VBZ	denotes	is
T1502	1859-1860	DT	denotes	a
T1503	1874-1881	NN	denotes	protein
T1504	1861-1865	NN	denotes	Ca2+
T1505	1866-1873	VBG	denotes	binding
T1506	1865-1866	HYPH	denotes	-
T1507	1882-1885	CC	denotes	and
T1508	1886-1893	VBZ	denotes	belongs
T1509	1894-1896	IN	denotes	to
T1510	1897-1900	DT	denotes	the
T1511	1923-1929	NN	denotes	family
T1512	1901-1906	NN	denotes	penta
T1513	1915-1922	NN	denotes	protein
T1514	1907-1909	NN	denotes	EF
T1515	1910-1914	NN	denotes	hand
T1516	1909-1910	HYPH	denotes	-
T1517	1930-1931	-LRB-	denotes	[
T1518	1931-1933	CD	denotes	14
T1519	1933-1934	-RRB-	denotes	]
T1520	1934-1935	.	denotes	.
T1521	1935-2001	sentence	denotes	Like annexin A7 it binds to membranes in a Ca2+-dependent manner.
T1522	1936-1940	IN	denotes	Like
T1523	1955-1960	VBZ	denotes	binds
T1524	1941-1948	NN	denotes	annexin
T1525	1949-1951	NN	denotes	A7
T1526	1952-1954	PRP	denotes	it
T1527	1961-1963	IN	denotes	to
T1528	1964-1973	NNS	denotes	membranes
T1529	1974-1976	IN	denotes	in
T1530	1977-1978	DT	denotes	a
T1531	1994-2000	NN	denotes	manner
T1532	1979-1983	NN	denotes	Ca2+
T1533	1984-1993	JJ	denotes	dependent
T1534	1983-1984	HYPH	denotes	-
T1535	2000-2001	.	denotes	.
T1536	2001-2125	sentence	denotes	Sorcin also has been described as interaction partner of the ryanodine receptor, and appears to modulate its function [15].
T1537	2002-2008	NN	denotes	Sorcin
T1538	2023-2032	VBN	denotes	described
T1539	2009-2013	RB	denotes	also
T1540	2014-2017	VBZ	denotes	has
T1541	2018-2022	VBN	denotes	been
T1542	2033-2035	IN	denotes	as
T1543	2036-2047	NN	denotes	interaction
T1544	2048-2055	NN	denotes	partner
T1545	2056-2058	IN	denotes	of
T1546	2059-2062	DT	denotes	the
T1547	2073-2081	NN	denotes	receptor
T1548	2063-2072	NN	denotes	ryanodine
T1549	2081-2083	,	denotes	,
T1550	2083-2086	CC	denotes	and
T1551	2087-2094	VBZ	denotes	appears
T1552	2095-2097	TO	denotes	to
T1553	2098-2106	VB	denotes	modulate
T1554	2107-2110	PRP$	denotes	its
T1555	2111-2119	NN	denotes	function
T1556	2120-2121	-LRB-	denotes	[
T1557	2121-2123	CD	denotes	15
T1558	2123-2124	-RRB-	denotes	]
T1559	2124-2125	.	denotes	.
T1560	2125-2214	sentence	denotes	The influence of the sorcin/annexin A7 interaction on the ryanodine receptor is unknown.
T1561	2126-2129	DT	denotes	The
T1562	2130-2139	NN	denotes	influence
T1563	2203-2205	VBZ	denotes	is
T1564	2140-2142	IN	denotes	of
T1565	2143-2146	DT	denotes	the
T1566	2165-2176	NN	denotes	interaction
T1567	2147-2153	NN	denotes	sorcin
T1568	2154-2161	NN	denotes	annexin
T1569	2153-2154	HYPH	denotes	/
T1570	2162-2164	NN	denotes	A7
T1571	2177-2179	IN	denotes	on
T1572	2180-2183	DT	denotes	the
T1573	2194-2202	NN	denotes	receptor
T1574	2184-2193	NN	denotes	ryanodine
T1575	2206-2213	JJ	denotes	unknown
T1576	2213-2214	.	denotes	.
T1577	2214-2289	sentence	denotes	Sorcin and annexin A7 are coexpressed in all tissues examined so far [11].
T1578	2215-2221	NN	denotes	Sorcin
T1579	2241-2252	VBN	denotes	coexpressed
T1580	2222-2225	CC	denotes	and
T1581	2226-2233	NN	denotes	annexin
T1582	2234-2236	NN	denotes	A7
T1583	2237-2240	VBP	denotes	are
T1584	2253-2255	IN	denotes	in
T1585	2256-2259	DT	denotes	all
T1586	2260-2267	NNS	denotes	tissues
T1587	2268-2276	VBN	denotes	examined
T1588	2277-2279	RB	denotes	so
T1589	2280-2283	RB	denotes	far
T1590	2284-2285	-LRB-	denotes	[
T1591	2285-2287	CD	denotes	11
T1592	2287-2288	-RRB-	denotes	]
T1593	2288-2289	.	denotes	.
T1594	2289-2390	sentence	denotes	The binding of annexin A7 and sorcin is Ca2+-dependent and occurs at micromolar Ca2+ concentrations.
T1595	2290-2293	DT	denotes	The
T1596	2294-2301	NN	denotes	binding
T1597	2327-2329	VBZ	denotes	is
T1598	2302-2304	IN	denotes	of
T1599	2305-2312	NN	denotes	annexin
T1600	2313-2315	NN	denotes	A7
T1601	2316-2319	CC	denotes	and
T1602	2320-2326	NN	denotes	sorcin
T1603	2330-2334	NN	denotes	Ca2+
T1604	2335-2344	JJ	denotes	dependent
T1605	2334-2335	HYPH	denotes	-
T1606	2345-2348	CC	denotes	and
T1607	2349-2355	VBZ	denotes	occurs
T1608	2356-2358	IN	denotes	at
T1609	2359-2369	JJ	denotes	micromolar
T1610	2370-2374	NN	denotes	Ca2+
T1611	2375-2389	NNS	denotes	concentrations
T1612	2389-2390	.	denotes	.
T1613	2390-2540	sentence	denotes	The binding sites have been localised to the amino terminal GGYY and GYGG motifs in sorcin and to the GYPP motif in the amino terminus of annexin A7.
T1614	2391-2394	DT	denotes	The
T1615	2403-2408	NNS	denotes	sites
T1616	2395-2402	VBG	denotes	binding
T1617	2419-2428	VBN	denotes	localised
T1618	2409-2413	VBP	denotes	have
T1619	2414-2418	VBN	denotes	been
T1620	2429-2431	IN	denotes	to
T1621	2432-2435	DT	denotes	the
T1622	2465-2471	NNS	denotes	motifs
T1623	2436-2441	NN	denotes	amino
T1624	2442-2450	JJ	denotes	terminal
T1625	2451-2455	NN	denotes	GGYY
T1626	2456-2459	CC	denotes	and
T1627	2460-2464	NN	denotes	GYGG
T1628	2472-2474	IN	denotes	in
T1629	2475-2481	NN	denotes	sorcin
T1630	2482-2485	CC	denotes	and
T1631	2486-2488	IN	denotes	to
T1632	2489-2492	DT	denotes	the
T1633	2498-2503	NN	denotes	motif
T1634	2493-2497	NN	denotes	GYPP
T1635	2504-2506	IN	denotes	in
T1636	2507-2510	DT	denotes	the
T1637	2517-2525	NN	denotes	terminus
T1638	2511-2516	NN	denotes	amino
T1639	2526-2528	IN	denotes	of
T1640	2529-2536	NN	denotes	annexin
T1641	2537-2539	NN	denotes	A7
T1642	2539-2540	.	denotes	.
T1643	2540-2647	sentence	denotes	The proteins bind to each other with a stoichiometry of two sorcin molecules per annexin A7 molecule [12].
T1644	2541-2544	DT	denotes	The
T1645	2545-2553	NN	denotes	proteins
T1646	2554-2558	VBP	denotes	bind
T1647	2559-2561	IN	denotes	to
T1648	2562-2566	DT	denotes	each
T1649	2567-2572	JJ	denotes	other
T1650	2573-2577	IN	denotes	with
T1651	2578-2579	DT	denotes	a
T1652	2580-2593	NN	denotes	stoichiometry
T1653	2594-2596	IN	denotes	of
T1654	2597-2600	CD	denotes	two
T1655	2608-2617	NNS	denotes	molecules
T1656	2601-2607	NN	denotes	sorcin
T1657	2618-2621	IN	denotes	per
T1658	2622-2629	NN	denotes	annexin
T1659	2630-2632	NN	denotes	A7
T1660	2633-2641	NN	denotes	molecule
T1661	2642-2643	-LRB-	denotes	[
T1662	2643-2645	CD	denotes	12
T1663	2645-2646	-RRB-	denotes	]
T1664	2646-2647	.	denotes	.
T1665	2647-2813	sentence	denotes	Galectin-3 is a multifunctional oncogenic protein with an anti-apoptotic activity found in the extracellular space, in the nucleus and cytoplasm and in mitochondria.
T1666	2648-2656	NN	denotes	Galectin
T1667	2659-2661	VBZ	denotes	is
T1668	2656-2657	HYPH	denotes	-
T1669	2657-2658	CD	denotes	3
T1670	2662-2663	DT	denotes	a
T1671	2690-2697	NN	denotes	protein
T1672	2664-2679	JJ	denotes	multifunctional
T1673	2680-2689	JJ	denotes	oncogenic
T1674	2698-2702	IN	denotes	with
T1675	2703-2705	DT	denotes	an
T1676	2721-2729	NN	denotes	activity
T1677	2706-2720	JJ	denotes	anti-apoptotic
T1678	2730-2735	VBN	denotes	found
T1679	2736-2738	IN	denotes	in
T1680	2739-2742	DT	denotes	the
T1681	2757-2762	NN	denotes	space
T1682	2743-2756	JJ	denotes	extracellular
T1683	2762-2764	,	denotes	,
T1684	2764-2766	IN	denotes	in
T1685	2767-2770	DT	denotes	the
T1686	2771-2778	NN	denotes	nucleus
T1687	2779-2782	CC	denotes	and
T1688	2783-2792	NN	denotes	cytoplasm
T1689	2793-2796	CC	denotes	and
T1690	2797-2799	IN	denotes	in
T1691	2800-2812	NNS	denotes	mitochondria
T1692	2812-2813	.	denotes	.
T1693	2813-2908	sentence	denotes	Cytoplasmic galectin-3 correlates with tumor progression and protects mitochondrial integrity.
T1694	2814-2825	JJ	denotes	Cytoplasmic
T1695	2826-2834	NN	denotes	galectin
T1696	2837-2847	VBZ	denotes	correlates
T1697	2834-2835	HYPH	denotes	-
T1698	2835-2836	CD	denotes	3
T1699	2848-2852	IN	denotes	with
T1700	2853-2858	NN	denotes	tumor
T1701	2859-2870	NN	denotes	progression
T1702	2871-2874	CC	denotes	and
T1703	2875-2883	VBZ	denotes	protects
T1704	2884-2897	JJ	denotes	mitochondrial
T1705	2898-2907	NN	denotes	integrity
T1706	2907-2908	.	denotes	.
T1707	2908-3036	sentence	denotes	Down regulation of annexin A7 prevents galectin-3 translocation to the perinuclear membrane and increases galectin-3 secretion.
T1708	2909-2913	NN	denotes	Down
T1709	2914-2924	NN	denotes	regulation
T1710	2939-2947	VBZ	denotes	prevents
T1711	2925-2927	IN	denotes	of
T1712	2928-2935	NN	denotes	annexin
T1713	2936-2938	NN	denotes	A7
T1714	2948-2956	NN	denotes	galectin
T1715	2957-2958	NN	denotes	3
T1716	2956-2957	HYPH	denotes	-
T1717	2959-2972	NN	denotes	translocation
T1718	2973-2975	IN	denotes	to
T1719	2976-2979	DT	denotes	the
T1720	2992-3000	NN	denotes	membrane
T1721	2980-2991	JJ	denotes	perinuclear
T1722	3001-3004	CC	denotes	and
T1723	3005-3014	VBZ	denotes	increases
T1724	3015-3023	NN	denotes	galectin
T1725	3024-3025	NN	denotes	3
T1726	3023-3024	HYPH	denotes	-
T1727	3026-3035	NN	denotes	secretion
T1728	3035-3036	.	denotes	.
T1729	3036-3155	sentence	denotes	For annexin A7 a role for galectin-3 trafficking, apoptosis regulation, and mitochondrial integrity was proposed [13].
T1730	3037-3040	IN	denotes	For
T1731	3141-3149	VBN	denotes	proposed
T1732	3041-3048	NN	denotes	annexin
T1733	3049-3051	NN	denotes	A7
T1734	3052-3053	DT	denotes	a
T1735	3054-3058	NN	denotes	role
T1736	3059-3062	IN	denotes	for
T1737	3063-3071	NN	denotes	galectin
T1738	3072-3073	NN	denotes	3
T1739	3071-3072	HYPH	denotes	-
T1740	3074-3085	NN	denotes	trafficking
T1741	3085-3087	,	denotes	,
T1742	3087-3096	NN	denotes	apoptosis
T1743	3097-3107	NN	denotes	regulation
T1744	3107-3109	,	denotes	,
T1745	3109-3112	CC	denotes	and
T1746	3113-3126	JJ	denotes	mitochondrial
T1747	3127-3136	NN	denotes	integrity
T1748	3137-3140	VBD	denotes	was
T1749	3150-3151	-LRB-	denotes	[
T1750	3151-3153	CD	denotes	13
T1751	3153-3154	-RRB-	denotes	]
T1752	3154-3155	.	denotes	.
T1753	3155-3211	sentence	denotes	The cellular role of annexin A7 is not well understood.
T1754	3156-3159	DT	denotes	The
T1755	3169-3173	NN	denotes	role
T1756	3160-3168	JJ	denotes	cellular
T1757	3200-3210	VBN	denotes	understood
T1758	3174-3176	IN	denotes	of
T1759	3177-3184	NN	denotes	annexin
T1760	3185-3187	NN	denotes	A7
T1761	3188-3190	VBZ	denotes	is
T1762	3191-3194	RB	denotes	not
T1763	3195-3199	RB	denotes	well
T1764	3210-3211	.	denotes	.
T1765	3211-3346	sentence	denotes	It is thought to regulate and stabilize membrane domains and to have a role in Ca2+ homeostasis and Ca2+-dependent signaling pathways.
T1766	3212-3214	PRP	denotes	It
T1767	3218-3225	VBN	denotes	thought
T1768	3215-3217	VBZ	denotes	is
T1769	3226-3228	TO	denotes	to
T1770	3229-3237	VB	denotes	regulate
T1771	3238-3241	CC	denotes	and
T1772	3242-3251	VB	denotes	stabilize
T1773	3252-3260	NN	denotes	membrane
T1774	3261-3268	NNS	denotes	domains
T1775	3269-3272	CC	denotes	and
T1776	3273-3275	TO	denotes	to
T1777	3276-3280	VB	denotes	have
T1778	3281-3282	DT	denotes	a
T1779	3283-3287	NN	denotes	role
T1780	3288-3290	IN	denotes	in
T1781	3291-3295	NN	denotes	Ca2+
T1782	3296-3307	NN	denotes	homeostasis
T1783	3308-3311	CC	denotes	and
T1784	3312-3316	NN	denotes	Ca2+
T1785	3317-3326	JJ	denotes	dependent
T1786	3316-3317	HYPH	denotes	-
T1787	3337-3345	NNS	denotes	pathways
T1788	3327-3336	NN	denotes	signaling
T1789	3345-3346	.	denotes	.
T1790	3346-3446	sentence	denotes	These proposals are supported by data obtained from analysis of annexin A7 deficient mouse mutants.
T1791	3347-3352	DT	denotes	These
T1792	3353-3362	NNS	denotes	proposals
T1793	3367-3376	VBN	denotes	supported
T1794	3363-3366	VBP	denotes	are
T1795	3377-3379	IN	denotes	by
T1796	3380-3384	NNS	denotes	data
T1797	3385-3393	VBN	denotes	obtained
T1798	3394-3398	IN	denotes	from
T1799	3399-3407	NN	denotes	analysis
T1800	3408-3410	IN	denotes	of
T1801	3411-3418	NN	denotes	annexin
T1802	3419-3421	NN	denotes	A7
T1803	3422-3431	JJ	denotes	deficient
T1804	3438-3445	NNS	denotes	mutants
T1805	3432-3437	NN	denotes	mouse
T1806	3445-3446	.	denotes	.
T1807	3446-3542	sentence	denotes	Two annexin A7 129Sv null mice strains were generated independently using a different strategy.
T1808	3447-3450	CD	denotes	Two
T1809	3478-3485	NNS	denotes	strains
T1810	3451-3458	NN	denotes	annexin
T1811	3459-3461	NN	denotes	A7
T1812	3462-3467	NN	denotes	129Sv
T1813	3468-3472	JJ	denotes	null
T1814	3473-3477	NNS	denotes	mice
T1815	3491-3500	VBN	denotes	generated
T1816	3486-3490	VBD	denotes	were
T1817	3501-3514	RB	denotes	independently
T1818	3515-3520	VBG	denotes	using
T1819	3521-3522	DT	denotes	a
T1820	3533-3541	NN	denotes	strategy
T1821	3523-3532	JJ	denotes	different
T1822	3541-3542	.	denotes	.
T1823	3542-3587	sentence	denotes	The one of Srivastava et al. [16] is lethal.
T1824	3543-3546	DT	denotes	The
T1825	3547-3550	CD	denotes	one
T1826	3577-3579	VBZ	denotes	is
T1827	3551-3553	IN	denotes	of
T1828	3554-3564	NNP	denotes	Srivastava
T1829	3565-3567	FW	denotes	et
T1830	3568-3571	FW	denotes	al.
T1831	3572-3573	-LRB-	denotes	[
T1832	3573-3575	CD	denotes	16
T1833	3575-3576	-RRB-	denotes	]
T1834	3580-3586	JJ	denotes	lethal
T1835	3586-3587	.	denotes	.
T1836	3587-3663	sentence	denotes	Heterozygous mice exhibit an insulin secretion defect and tumor phenotypes.
T1837	3588-3600	JJ	denotes	Heterozygous
T1838	3601-3605	NNS	denotes	mice
T1839	3606-3613	VBP	denotes	exhibit
T1840	3614-3616	DT	denotes	an
T1841	3635-3641	NN	denotes	defect
T1842	3617-3624	NN	denotes	insulin
T1843	3625-3634	NN	denotes	secretion
T1844	3642-3645	CC	denotes	and
T1845	3646-3651	NN	denotes	tumor
T1846	3652-3662	NNS	denotes	phenotypes
T1847	3662-3663	.	denotes	.
T1848	3663-3792	sentence	denotes	The null strain reported by Herr et al. [17] is viable, healthy, and shows no insulin secretion defect or other obvious defects.
T1849	3664-3667	DT	denotes	The
T1850	3673-3679	NN	denotes	strain
T1851	3668-3672	JJ	denotes	null
T1852	3709-3711	VBZ	denotes	is
T1853	3680-3688	VBN	denotes	reported
T1854	3689-3691	IN	denotes	by
T1855	3692-3696	NNP	denotes	Herr
T1856	3697-3699	FW	denotes	et
T1857	3700-3703	FW	denotes	al.
T1858	3704-3705	-LRB-	denotes	[
T1859	3705-3707	CD	denotes	17
T1860	3707-3708	-RRB-	denotes	]
T1861	3712-3718	JJ	denotes	viable
T1862	3720-3727	JJ	denotes	healthy
T1863	3718-3720	,	denotes	,
T1864	3727-3729	,	denotes	,
T1865	3729-3732	CC	denotes	and
T1866	3733-3738	VBZ	denotes	shows
T1867	3739-3741	DT	denotes	no
T1868	3760-3766	NN	denotes	defect
T1869	3742-3749	NN	denotes	insulin
T1870	3750-3759	NN	denotes	secretion
T1871	3767-3769	CC	denotes	or
T1872	3770-3775	JJ	denotes	other
T1873	3784-3791	NNS	denotes	defects
T1874	3776-3783	JJ	denotes	obvious
T1875	3791-3792	.	denotes	.
T1876	3792-3875	sentence	denotes	However, in isolated cardiomyocytes the frequency-induced shortening is disturbed.
T1877	3793-3800	RB	denotes	However
T1878	3865-3874	VBN	denotes	disturbed
T1879	3800-3802	,	denotes	,
T1880	3802-3804	IN	denotes	in
T1881	3805-3813	VBN	denotes	isolated
T1882	3814-3828	NNS	denotes	cardiomyocytes
T1883	3829-3832	DT	denotes	the
T1884	3851-3861	NN	denotes	shortening
T1885	3833-3842	NN	denotes	frequency
T1886	3843-3850	VBN	denotes	induced
T1887	3842-3843	HYPH	denotes	-
T1888	3862-3864	VBZ	denotes	is
T1889	3874-3875	.	denotes	.
T1890	3875-3969	sentence	denotes	Here we have focused on the analysis of red blood cells and platelets of the anxA7-/- mutant.
T1891	3876-3880	RB	denotes	Here
T1892	3889-3896	VBN	denotes	focused
T1893	3881-3883	PRP	denotes	we
T1894	3884-3888	VBP	denotes	have
T1895	3897-3899	IN	denotes	on
T1896	3900-3903	DT	denotes	the
T1897	3904-3912	NN	denotes	analysis
T1898	3913-3915	IN	denotes	of
T1899	3916-3919	JJ	denotes	red
T1900	3926-3931	NNS	denotes	cells
T1901	3920-3925	NN	denotes	blood
T1902	3932-3935	CC	denotes	and
T1903	3936-3945	NNS	denotes	platelets
T1904	3946-3948	IN	denotes	of
T1905	3949-3952	DT	denotes	the
T1906	3962-3968	NN	denotes	mutant
T1907	3953-3958	JJ	denotes	anxA7
T1908	3958-3959	SYM	denotes	-
T1909	3959-3960	HYPH	denotes	/
T1910	3960-3961	SYM	denotes	-
T1911	3968-3969	.	denotes	.
T1912	3969-4141	sentence	denotes	Generally, red blood cells and platelets were thought not to contain annexin A7 and only recently the 47 kDa isoform has been reported as component of red blood cells [7].
T1913	3970-3979	RB	denotes	Generally
T1914	4016-4023	VBN	denotes	thought
T1915	3979-3981	,	denotes	,
T1916	3981-3984	JJ	denotes	red
T1917	3991-3996	NNS	denotes	cells
T1918	3985-3990	NN	denotes	blood
T1919	3997-4000	CC	denotes	and
T1920	4001-4010	NNS	denotes	platelets
T1921	4011-4015	VBD	denotes	were
T1922	4024-4027	RB	denotes	not
T1923	4028-4030	TO	denotes	to
T1924	4031-4038	VB	denotes	contain
T1925	4039-4046	NN	denotes	annexin
T1926	4047-4049	NN	denotes	A7
T1927	4050-4053	CC	denotes	and
T1928	4054-4058	RB	denotes	only
T1929	4059-4067	RB	denotes	recently
T1930	4096-4104	VBN	denotes	reported
T1931	4068-4071	DT	denotes	the
T1932	4079-4086	NN	denotes	isoform
T1933	4072-4074	CD	denotes	47
T1934	4075-4078	NN	denotes	kDa
T1935	4087-4090	VBZ	denotes	has
T1936	4091-4095	VBN	denotes	been
T1937	4105-4107	IN	denotes	as
T1938	4108-4117	NN	denotes	component
T1939	4118-4120	IN	denotes	of
T1940	4121-4124	JJ	denotes	red
T1941	4131-4136	NNS	denotes	cells
T1942	4125-4130	NN	denotes	blood
T1943	4137-4138	-LRB-	denotes	[
T1944	4138-4139	CD	denotes	7
T1945	4139-4140	-RRB-	denotes	]
T1946	4140-4141	.	denotes	.
T1947	4141-4262	sentence	denotes	Red blood cells undergo various biochemical or morphological changes that appear to be Ca2+-dependent processes [18,19].
T1948	4142-4145	JJ	denotes	Red
T1949	4152-4157	NNS	denotes	cells
T1950	4146-4151	NN	denotes	blood
T1951	4158-4165	VBP	denotes	undergo
T1952	4166-4173	JJ	denotes	various
T1953	4203-4210	NNS	denotes	changes
T1954	4174-4185	JJ	denotes	biochemical
T1955	4186-4188	CC	denotes	or
T1956	4189-4202	JJ	denotes	morphological
T1957	4211-4215	WDT	denotes	that
T1958	4216-4222	VBP	denotes	appear
T1959	4223-4225	TO	denotes	to
T1960	4226-4228	VB	denotes	be
T1961	4229-4233	NN	denotes	Ca2+
T1962	4234-4243	JJ	denotes	dependent
T1963	4233-4234	HYPH	denotes	-
T1964	4244-4253	NNS	denotes	processes
T1965	4254-4255	-LRB-	denotes	[
T1966	4258-4260	CD	denotes	19
T1967	4255-4257	CD	denotes	18
T1968	4257-4258	,	denotes	,
T1969	4260-4261	-RRB-	denotes	]
T1970	4261-4262	.	denotes	.
T1971	4262-4372	sentence	denotes	One of them is the release of hemoglobin-containing exovesicles occurring in vivo as well as in vitro [7,20].
T1972	4263-4266	CD	denotes	One
T1973	4275-4277	VBZ	denotes	is
T1974	4267-4269	IN	denotes	of
T1975	4270-4274	PRP	denotes	them
T1976	4278-4281	DT	denotes	the
T1977	4282-4289	NN	denotes	release
T1978	4290-4292	IN	denotes	of
T1979	4293-4303	NN	denotes	hemoglobin
T1980	4304-4314	VBG	denotes	containing
T1981	4303-4304	HYPH	denotes	-
T1982	4315-4326	NNS	denotes	exovesicles
T1983	4327-4336	VBG	denotes	occurring
T1984	4337-4339	FW	denotes	in
T1985	4340-4344	FW	denotes	vivo
T1986	4345-4347	RB	denotes	as
T1987	4353-4355	IN	denotes	as
T1988	4348-4352	RB	denotes	well
T1989	4356-4358	FW	denotes	in
T1990	4359-4364	FW	denotes	vitro
T1991	4365-4366	-LRB-	denotes	[
T1992	4368-4370	CD	denotes	20
T1993	4366-4367	CD	denotes	7
T1994	4367-4368	,	denotes	,
T1995	4370-4371	-RRB-	denotes	]
T1996	4371-4372	.	denotes	.
T1997	4372-4507	sentence	denotes	This process is thought to represent a protective method of the red blood cell against an attack by for example complement components.
T1998	4373-4377	DT	denotes	This
T1999	4378-4385	NN	denotes	process
T2000	4389-4396	VBN	denotes	thought
T2001	4386-4388	VBZ	denotes	is
T2002	4397-4399	TO	denotes	to
T2003	4400-4409	VB	denotes	represent
T2004	4410-4411	DT	denotes	a
T2005	4423-4429	NN	denotes	method
T2006	4412-4422	JJ	denotes	protective
T2007	4430-4432	IN	denotes	of
T2008	4433-4436	DT	denotes	the
T2009	4447-4451	NN	denotes	cell
T2010	4437-4440	JJ	denotes	red
T2011	4441-4446	NN	denotes	blood
T2012	4452-4459	IN	denotes	against
T2013	4460-4462	DT	denotes	an
T2014	4463-4469	NN	denotes	attack
T2015	4470-4472	IN	denotes	by
T2016	4473-4476	IN	denotes	for
T2017	4496-4506	NNS	denotes	components
T2018	4477-4484	NN	denotes	example
T2019	4485-4495	NN	denotes	complement
T2020	4506-4507	.	denotes	.
T2021	4507-4634	sentence	denotes	Red blood cells which lack the ability to vesiculate cause a disease with red blood cell destruction and haemoglobinuria [21].
T2022	4508-4511	JJ	denotes	Red
T2023	4518-4523	NNS	denotes	cells
T2024	4512-4517	NN	denotes	blood
T2025	4561-4566	VB	denotes	cause
T2026	4524-4529	WDT	denotes	which
T2027	4530-4534	VBP	denotes	lack
T2028	4535-4538	DT	denotes	the
T2029	4539-4546	NN	denotes	ability
T2030	4547-4549	TO	denotes	to
T2031	4550-4560	VB	denotes	vesiculate
T2032	4567-4568	DT	denotes	a
T2033	4569-4576	NN	denotes	disease
T2034	4577-4581	IN	denotes	with
T2035	4582-4585	JJ	denotes	red
T2036	4592-4596	NN	denotes	cell
T2037	4586-4591	NN	denotes	blood
T2038	4597-4608	NN	denotes	destruction
T2039	4609-4612	CC	denotes	and
T2040	4613-4628	NN	denotes	haemoglobinuria
T2041	4629-4630	-LRB-	denotes	[
T2042	4630-4632	CD	denotes	21
T2043	4632-4633	-RRB-	denotes	]
T2044	4633-4634	.	denotes	.
T2045	4634-4740	sentence	denotes	There exist two types of vesicles, micro- and nanovesicles with a size of 180 nm and 60 nm, respectively.
T2046	4635-4640	EX	denotes	There
T2047	4641-4646	VBP	denotes	exist
T2048	4647-4650	CD	denotes	two
T2049	4651-4656	NNS	denotes	types
T2050	4657-4659	IN	denotes	of
T2051	4660-4668	NNS	denotes	vesicles
T2052	4668-4670	,	denotes	,
T2053	4670-4675	AFX	denotes	micro
T2054	4681-4693	NNS	denotes	nanovesicles
T2055	4675-4676	HYPH	denotes	-
T2056	4677-4680	CC	denotes	and
T2057	4694-4698	IN	denotes	with
T2058	4699-4700	DT	denotes	a
T2059	4701-4705	NN	denotes	size
T2060	4706-4708	IN	denotes	of
T2061	4709-4712	CD	denotes	180
T2062	4713-4715	NN	denotes	nm
T2063	4716-4719	CC	denotes	and
T2064	4720-4722	CD	denotes	60
T2065	4723-4725	NN	denotes	nm
T2066	4725-4727	,	denotes	,
T2067	4727-4739	RB	denotes	respectively
T2068	4739-4740	.	denotes	.
T2069	4740-5026	sentence	denotes	They are enriched in cholesterol and sphingolipid rich lipid raft domains that are associated with proteins like acetylcholinesterase, cell surface proteins including a complement receptor, and the lipid raft proteins stomatin and flotillin, but they lack any cytoskeletal protein [7].
T2070	4741-4745	PRP	denotes	They
T2071	4750-4758	VBN	denotes	enriched
T2072	4746-4749	VBP	denotes	are
T2073	4759-4761	IN	denotes	in
T2074	4762-4773	NN	denotes	cholesterol
T2075	4791-4795	JJ	denotes	rich
T2076	4774-4777	CC	denotes	and
T2077	4778-4790	NN	denotes	sphingolipid
T2078	4807-4814	NNS	denotes	domains
T2079	4796-4801	NN	denotes	lipid
T2080	4802-4806	NN	denotes	raft
T2081	4815-4819	WDT	denotes	that
T2082	4824-4834	VBN	denotes	associated
T2083	4820-4823	VBP	denotes	are
T2084	4835-4839	IN	denotes	with
T2085	4840-4848	NN	denotes	proteins
T2086	4849-4853	IN	denotes	like
T2087	4854-4874	NN	denotes	acetylcholinesterase
T2088	4874-4876	,	denotes	,
T2089	4876-4880	NN	denotes	cell
T2090	4889-4897	NN	denotes	proteins
T2091	4881-4888	NN	denotes	surface
T2092	4898-4907	VBG	denotes	including
T2093	4908-4909	DT	denotes	a
T2094	4921-4929	NN	denotes	receptor
T2095	4910-4920	NN	denotes	complement
T2096	4929-4931	,	denotes	,
T2097	4931-4934	CC	denotes	and
T2098	4935-4938	DT	denotes	the
T2099	4950-4958	NN	denotes	proteins
T2100	4939-4944	NN	denotes	lipid
T2101	4945-4949	NN	denotes	raft
T2102	4959-4967	NN	denotes	stomatin
T2103	4968-4971	CC	denotes	and
T2104	4972-4981	NN	denotes	flotillin
T2105	4981-4983	,	denotes	,
T2106	4983-4986	CC	denotes	but
T2107	4987-4991	PRP	denotes	they
T2108	4992-4996	VBP	denotes	lack
T2109	4997-5000	DT	denotes	any
T2110	5014-5021	NN	denotes	protein
T2111	5001-5013	JJ	denotes	cytoskeletal
T2112	5022-5023	-LRB-	denotes	[
T2113	5023-5024	CD	denotes	7
T2114	5024-5025	-RRB-	denotes	]
T2115	5025-5026	.	denotes	.
T2116	5026-5103	sentence	denotes	Furthermore, they contain sorcin and annexin A7 attached to the lipid rafts.
T2117	5027-5038	RB	denotes	Furthermore
T2118	5045-5052	VBP	denotes	contain
T2119	5038-5040	,	denotes	,
T2120	5040-5044	PRP	denotes	they
T2121	5053-5059	NN	denotes	sorcin
T2122	5060-5063	CC	denotes	and
T2123	5064-5071	NN	denotes	annexin
T2124	5072-5074	NN	denotes	A7
T2125	5075-5083	VBN	denotes	attached
T2126	5084-5086	IN	denotes	to
T2127	5087-5090	DT	denotes	the
T2128	5097-5102	NNS	denotes	rafts
T2129	5091-5096	NN	denotes	lipid
T2130	5102-5103	.	denotes	.
T2131	5103-5152	sentence	denotes	Both proteins are more abundant in nanovesicles.
T2132	5104-5108	DT	denotes	Both
T2133	5109-5117	NN	denotes	proteins
T2134	5118-5121	VBP	denotes	are
T2135	5122-5126	RBR	denotes	more
T2136	5127-5135	JJ	denotes	abundant
T2137	5136-5138	IN	denotes	in
T2138	5139-5151	NNS	denotes	nanovesicles
T2139	5151-5152	.	denotes	.
T2140	5152-5337	sentence	denotes	The vesicle formation goes along with several other changes in the red blood cell like cytoskeletal rearrangements and changes in the phospholipid orientation in the cellular membrane.
T2141	5153-5156	DT	denotes	The
T2142	5165-5174	NN	denotes	formation
T2143	5157-5164	NN	denotes	vesicle
T2144	5175-5179	VBZ	denotes	goes
T2145	5180-5185	RP	denotes	along
T2146	5186-5190	IN	denotes	with
T2147	5191-5198	JJ	denotes	several
T2148	5205-5212	NNS	denotes	changes
T2149	5199-5204	JJ	denotes	other
T2150	5213-5215	IN	denotes	in
T2151	5216-5219	DT	denotes	the
T2152	5230-5234	NN	denotes	cell
T2153	5220-5223	JJ	denotes	red
T2154	5224-5229	NN	denotes	blood
T2155	5235-5239	IN	denotes	like
T2156	5240-5252	JJ	denotes	cytoskeletal
T2157	5253-5267	NNS	denotes	rearrangements
T2158	5268-5271	CC	denotes	and
T2159	5272-5279	NNS	denotes	changes
T2160	5280-5282	IN	denotes	in
T2161	5283-5286	DT	denotes	the
T2162	5300-5311	NN	denotes	orientation
T2163	5287-5299	NN	denotes	phospholipid
T2164	5312-5314	IN	denotes	in
T2165	5315-5318	DT	denotes	the
T2166	5328-5336	NN	denotes	membrane
T2167	5319-5327	JJ	denotes	cellular
T2168	5336-5337	.	denotes	.
T2443	5348-5355	NN	denotes	Annexin
T2444	5356-5358	NN	denotes	A7
T2445	5359-5369	NN	denotes	expression
T2446	5370-5372	IN	denotes	in
T2447	5373-5376	JJ	denotes	red
T2448	5383-5388	NNS	denotes	cells
T2449	5377-5382	NN	denotes	blood
T2450	5388-5390	,	denotes	,
T2451	5390-5393	JJ	denotes	red
T2452	5400-5404	NN	denotes	cell
T2453	5394-5399	NN	denotes	blood
T2454	5405-5412	VBN	denotes	derived
T2455	5413-5424	NNS	denotes	exovesicles
T2456	5425-5428	CC	denotes	and
T2457	5429-5431	IN	denotes	in
T2458	5432-5441	NNS	denotes	platelets
T2459	5441-5682	sentence	denotes	Salzer et al. recently reported the presence of the 47 kDa isoform of annexin A7 and its partner sorcin in micro- and nanovesicles derived from red blood cells where they are located in the lumen and are also enriched in membrane rafts [7].
T2460	5442-5448	NNP	denotes	Salzer
T2461	5465-5473	VBD	denotes	reported
T2462	5449-5451	FW	denotes	et
T2463	5452-5455	FW	denotes	al.
T2464	5456-5464	RB	denotes	recently
T2465	5474-5477	DT	denotes	the
T2466	5478-5486	NN	denotes	presence
T2467	5487-5489	IN	denotes	of
T2468	5490-5493	DT	denotes	the
T2469	5501-5508	NN	denotes	isoform
T2470	5494-5496	CD	denotes	47
T2471	5497-5500	NN	denotes	kDa
T2472	5509-5511	IN	denotes	of
T2473	5512-5519	NN	denotes	annexin
T2474	5520-5522	NN	denotes	A7
T2475	5523-5526	CC	denotes	and
T2476	5527-5530	PRP$	denotes	its
T2477	5531-5538	NN	denotes	partner
T2478	5539-5545	NN	denotes	sorcin
T2479	5546-5548	IN	denotes	in
T2480	5549-5554	NN	denotes	micro
T2481	5554-5555	HYPH	denotes	-
T2482	5556-5559	CC	denotes	and
T2483	5560-5572	NNS	denotes	nanovesicles
T2484	5573-5580	VBN	denotes	derived
T2485	5581-5585	IN	denotes	from
T2486	5586-5589	JJ	denotes	red
T2487	5596-5601	NNS	denotes	cells
T2488	5590-5595	NN	denotes	blood
T2489	5602-5607	WRB	denotes	where
T2490	5617-5624	VBN	denotes	located
T2491	5608-5612	PRP	denotes	they
T2492	5613-5616	VBP	denotes	are
T2493	5625-5627	IN	denotes	in
T2494	5628-5631	DT	denotes	the
T2495	5632-5637	NN	denotes	lumen
T2496	5638-5641	CC	denotes	and
T2497	5642-5645	VBP	denotes	are
T2498	5651-5659	VBN	denotes	enriched
T2499	5646-5650	RB	denotes	also
T2500	5660-5662	IN	denotes	in
T2501	5663-5671	NN	denotes	membrane
T2502	5672-5677	NNS	denotes	rafts
T2503	5678-5679	-LRB-	denotes	[
T2504	5679-5680	CD	denotes	7
T2505	5680-5681	-RRB-	denotes	]
T2506	5681-5682	.	denotes	.
T2507	5682-5776	sentence	denotes	We have now extended these findings and show here that the 51 kDa isoform is present as well.
T2508	5683-5685	PRP	denotes	We
T2509	5695-5703	VBN	denotes	extended
T2510	5686-5690	VBP	denotes	have
T2511	5691-5694	RB	denotes	now
T2512	5704-5709	DT	denotes	these
T2513	5710-5718	NNS	denotes	findings
T2514	5719-5722	CC	denotes	and
T2515	5723-5727	VBP	denotes	show
T2516	5728-5732	RB	denotes	here
T2517	5733-5737	IN	denotes	that
T2518	5757-5759	VBZ	denotes	is
T2519	5738-5741	DT	denotes	the
T2520	5749-5756	NN	denotes	isoform
T2521	5742-5744	CD	denotes	51
T2522	5745-5748	NN	denotes	kDa
T2523	5760-5767	JJ	denotes	present
T2524	5768-5770	RB	denotes	as
T2525	5771-5775	RB	denotes	well
T2526	5775-5776	.	denotes	.
T2527	5776-5887	sentence	denotes	In western blots of human red blood cells the 47 and 51 kDa isoforms were detected using mAb 203–217 (Fig. 1).
T2528	5777-5779	IN	denotes	In
T2529	5851-5859	VBN	denotes	detected
T2530	5780-5787	JJ	denotes	western
T2531	5788-5793	NNS	denotes	blots
T2532	5794-5796	IN	denotes	of
T2533	5797-5802	JJ	denotes	human
T2534	5813-5818	NNS	denotes	cells
T2535	5803-5806	JJ	denotes	red
T2536	5807-5812	NN	denotes	blood
T2537	5819-5822	DT	denotes	the
T2538	5837-5845	NNS	denotes	isoforms
T2539	5823-5825	CD	denotes	47
T2540	5833-5836	NN	denotes	kDa
T2541	5826-5829	CC	denotes	and
T2542	5830-5832	CD	denotes	51
T2543	5846-5850	VBD	denotes	were
T2544	5860-5865	VBG	denotes	using
T2545	5866-5869	NN	denotes	mAb
T2546	5870-5877	CD	denotes	203–217
T2547	5878-5879	-LRB-	denotes	(
T2548	5879-5883	NN	denotes	Fig.
T2549	5884-5885	CD	denotes	1
T2550	5885-5886	-RRB-	denotes	)
T2551	5886-5887	.	denotes	.
T2552	5887-6034	sentence	denotes	The 47 kDa isoform was detected in silver stained gels and its identity with annexin A7 confirmed by peptide mass fingerprinting (data not shown).
T2553	5888-5891	DT	denotes	The
T2606	6528-6533	IN	denotes	along
T2607	6534-6538	IN	denotes	with
T2608	6539-6543	NN	denotes	raft
T2609	6544-6551	NNS	denotes	domains
T2610	6551-6553	,	denotes	,
T2611	6553-6560	NN	denotes	annexin
T2612	6561-6563	NN	denotes	A7
T2613	6570-6571	DT	denotes	a
T2614	6572-6576	NN	denotes	role
T2615	6577-6579	IN	denotes	in
T2616	6580-6588	NN	denotes	membrane
T2617	6589-6601	NN	denotes	organization
T2618	6602-6605	CC	denotes	and
T2619	6606-6609	DT	denotes	the
T2620	6623-6630	NN	denotes	process
T2621	6610-6622	NN	denotes	vesiculation
T2622	6630-6631	.	denotes	.
T2623	6631-6766	sentence	denotes	To examine this, we analysed the ability of red blood cells derived from the annexin A7 knock out mice (anxA7-/-) to form exovesicles.
T2624	6632-6634	TO	denotes	To
T2625	6635-6642	VB	denotes	examine
T2626	6652-6660	VBD	denotes	analysed
T2627	6643-6647	DT	denotes	this
T2628	6647-6649	,	denotes	,
T2629	6649-6651	PRP	denotes	we
T2630	6661-6664	DT	denotes	the
T2631	6665-6672	NN	denotes	ability
T2632	6673-6675	IN	denotes	of
T2633	6676-6679	JJ	denotes	red
T2634	6686-6691	NNS	denotes	cells
T2635	6680-6685	NN	denotes	blood
T2636	6692-6699	VBN	denotes	derived
T2637	6700-6704	IN	denotes	from
T2638	6705-6708	DT	denotes	the
T2639	6730-6734	NNS	denotes	mice
T2640	6709-6716	NN	denotes	annexin
T2641	6717-6719	NN	denotes	A7
T2642	6720-6725	NN	denotes	knock
T2643	6726-6729	NN	denotes	out
T2644	6735-6736	-LRB-	denotes	(
T2645	6736-6741	NN	denotes	anxA7
T2646	6741-6742	SYM	denotes	-
T2647	6742-6743	HYPH	denotes	/
T2648	6743-6744	SYM	denotes	-
T2649	6744-6745	-RRB-	denotes	)
T2650	6746-6748	TO	denotes	to
T2651	6749-6753	VB	denotes	form
T2652	6754-6765	NNS	denotes	exovesicles
T2653	6765-6766	.	denotes	.
T2654	6766-6902	sentence	denotes	Because of better accessibility and larger available amounts that led to clear results, we included our data obtained with human blood.
T2655	6767-6774	IN	denotes	Because
T2656	6858-6866	VBD	denotes	included
T2657	6775-6777	IN	denotes	of
T2658	6778-6784	JJR	denotes	better
T2659	6785-6798	NN	denotes	accessibility
T2660	6799-6802	CC	denotes	and
T2661	6803-6809	JJR	denotes	larger
T2662	6820-6827	NNS	denotes	amounts
T2663	6810-6819	JJ	denotes	available
T2664	6828-6832	WDT	denotes	that
T2665	6833-6836	VBD	denotes	led
T2666	6837-6839	IN	denotes	to
T2667	6840-6845	JJ	denotes	clear
T2668	6846-6853	NNS	denotes	results
T2669	6853-6855	,	denotes	,
T2670	6855-6857	PRP	denotes	we
T2671	6867-6870	PRP$	denotes	our
T2672	6871-6875	NNS	denotes	data
T2673	6876-6884	VBN	denotes	obtained
T2674	6885-6889	IN	denotes	with
T2675	6890-6895	JJ	denotes	human
T2676	6896-6901	NN	denotes	blood
T2677	6901-6902	.	denotes	.
T2678	6902-7119	sentence	denotes	Independent of the presence of annexin A7 both types of exovesicles, micro- and nanovesicles, were released after Ca2+/ionophore treatment as determined by acetylcholine esterase activity and microscopic examination.
T2679	6903-6914	JJ	denotes	Independent
T2680	7002-7010	VBN	denotes	released
T2681	6915-6917	IN	denotes	of
T2682	6918-6921	DT	denotes	the
T2683	6922-6930	NN	denotes	presence
T2684	6931-6933	IN	denotes	of
T2685	6934-6941	NN	denotes	annexin
T2686	6942-6944	NN	denotes	A7
T2687	6945-6949	DT	denotes	both
T2688	6950-6955	NNS	denotes	types
T2689	6956-6958	IN	denotes	of
T2690	6959-6970	NNS	denotes	exovesicles
T2691	6970-6972	,	denotes	,
T2692	6972-6977	AFX	denotes	micro
T2693	6983-6995	NNS	denotes	nanovesicles
T2694	6977-6978	HYPH	denotes	-
T2695	6979-6982	CC	denotes	and
T2696	6995-6997	,	denotes	,
T2697	6997-7001	VBD	denotes	were
T2698	7011-7016	IN	denotes	after
T2699	7017-7021	NN	denotes	Ca2+
T2700	7022-7031	NN	denotes	ionophore
T2701	7021-7022	HYPH	denotes	/
T2702	7032-7041	NN	denotes	treatment
T2703	7042-7044	IN	denotes	as
T2704	7045-7055	VBN	denotes	determined
T2705	7056-7058	IN	denotes	by
T2706	7059-7072	NN	denotes	acetylcholine
T2707	7073-7081	NN	denotes	esterase
T2708	7082-7090	NN	denotes	activity
T2709	7091-7094	CC	denotes	and
T2710	7095-7106	JJ	denotes	microscopic
T2711	7107-7118	NN	denotes	examination
T2712	7118-7119	.	denotes	.
T2713	7119-7215	sentence	denotes	Annexin A7 is present in both vesicle types where it is more enriched in nanovesicles (Fig. 2).
T2714	7120-7127	NN	denotes	Annexin
T2715	7128-7130	NN	denotes	A7
T2716	7131-7133	VBZ	denotes	is
T2717	7134-7141	JJ	denotes	present
T2718	7142-7144	IN	denotes	in
T2719	7145-7149	CC	denotes	both
T2720	7158-7163	NNS	denotes	types
T2721	7150-7157	NN	denotes	vesicle
T2722	7164-7169	WRB	denotes	where
T2723	7173-7175	VBZ	denotes	is
T2724	7170-7172	PRP	denotes	it
T2725	7176-7180	RBR	denotes	more
T2726	7181-7189	JJ	denotes	enriched
T2727	7190-7192	IN	denotes	in
T2728	7193-7205	NNS	denotes	nanovesicles
T2729	7206-7207	-LRB-	denotes	(
T2730	7207-7211	NN	denotes	Fig.
T2731	7212-7213	CD	denotes	2
T2732	7213-7214	-RRB-	denotes	)
T2733	7214-7215	.	denotes	.
T2734	7215-7270	sentence	denotes	The 51 kDa isoform is only detectable in nanovesicles.
T2735	7216-7219	DT	denotes	The
T2736	7227-7234	NN	denotes	isoform
T2737	7220-7222	CD	denotes	51
T2738	7223-7226	NN	denotes	kDa
T2739	7235-7237	VBZ	denotes	is
T2740	7238-7242	RB	denotes	only
T2741	7243-7253	JJ	denotes	detectable
T2742	7254-7256	IN	denotes	in
T2743	7257-7269	NNS	denotes	nanovesicles
T2744	7269-7270	.	denotes	.
T2745	7270-7484	sentence	denotes	The quantity of both vesicle types did not differ between wild type and knock out red blood cell vesicles as determined by the AChE-values (A405 nanovesicles: ~0.18; A405 microvesicles: ~0.9; both, for wt and ko).
T2746	7271-7274	DT	denotes	The
T2747	7275-7283	NN	denotes	quantity
T2748	7314-7320	VB	denotes	differ
T2749	7284-7286	IN	denotes	of
T2750	7287-7291	DT	denotes	both
T2751	7300-7305	NNS	denotes	types
T2752	7292-7299	NN	denotes	vesicle
T2753	7306-7309	VBD	denotes	did
T2754	7310-7313	RB	denotes	not
T2755	7321-7328	IN	denotes	between
T2756	7329-7333	JJ	denotes	wild
T2757	7334-7338	NN	denotes	type
T2758	7368-7376	NNS	denotes	vesicles
T2759	7339-7342	CC	denotes	and
T2760	7343-7348	NN	denotes	knock
T2761	7349-7352	NN	denotes	out
T2762	7353-7356	JJ	denotes	red
T2763	7363-7367	NN	denotes	cell
T2764	7357-7362	NN	denotes	blood
T2765	7377-7379	IN	denotes	as
T2766	7380-7390	VBN	denotes	determined
T2767	7391-7393	IN	denotes	by
T2768	7394-7397	DT	denotes	the
T2769	7403-7409	NNS	denotes	values
T2770	7398-7402	NN	denotes	AChE
T2771	7402-7403	HYPH	denotes	-
T2772	7410-7411	-LRB-	denotes	(
T2773	7463-7467	DT	denotes	both
T2774	7411-7415	NN	denotes	A405
T2775	7416-7428	NNS	denotes	nanovesicles
T2776	7431-7435	CD	denotes	0.18
T2777	7428-7430	:	denotes	:
T2778	7430-7431	SYM	denotes	~
T2779	7435-7436	:	denotes	;
T2780	7437-7441	NN	denotes	A405
T2781	7442-7455	NNS	denotes	microvesicles
T2782	7458-7461	CD	denotes	0.9
T2783	7455-7457	:	denotes	:
T2784	7457-7458	SYM	denotes	~
T2785	7461-7462	:	denotes	;
T2786	7467-7469	,	denotes	,
T2787	7469-7472	IN	denotes	for
T2788	7473-7475	NN	denotes	wt
T2789	7476-7479	CC	denotes	and
T2790	7480-7482	NN	denotes	ko
T2791	7482-7483	-RRB-	denotes	)
T2832	7668-7671	DT	denotes	the
T2833	7672-7680	NN	denotes	presence
T2834	7681-7683	IN	denotes	of
T2835	7684-7690	NN	denotes	sorcin
T2836	7691-7693	IN	denotes	in
T2837	7694-7698	JJ	denotes	wild
T2838	7699-7703	NN	denotes	type
T2839	7715-7723	NNS	denotes	vesicles
T2840	7704-7707	CC	denotes	and
T2841	7708-7714	JJ	denotes	mutant
T2842	7724-7726	PRP	denotes	we
T2843	7733-7737	IN	denotes	that
T2844	7761-7768	VBN	denotes	reduced
T2845	7738-7741	DT	denotes	the
T2846	7749-7755	NNS	denotes	levels
T2847	7742-7748	NN	denotes	sorcin
T2848	7756-7760	VBD	denotes	were
T2849	7769-7771	IN	denotes	in
T2850	7772-7775	DT	denotes	the
T2851	7783-7795	NNS	denotes	nanovesicles
T2852	7776-7782	JJ	denotes	mutant
T2853	7796-7797	-LRB-	denotes	(
T2854	7797-7801	NN	denotes	Fig.
T2855	7802-7803	CD	denotes	2
T2856	7803-7804	-RRB-	denotes	)
T2857	7804-7805	.	denotes	.
T2880	8556-8564	NNS	denotes	isoforms
T2881	8565-8569	VBD	denotes	were
T2882	8570-8577	JJ	denotes	present
T2883	8578-8580	IN	denotes	in
T2884	8581-8584	DT	denotes	the
T2885	8593-8601	NN	denotes	fraction
T2886	8585-8592	JJ	denotes	soluble
T2887	8602-8604	RB	denotes	as
T2888	8610-8612	IN	denotes	as
T2889	8605-8609	RB	denotes	well
T2890	8613-8615	IN	denotes	in
T2891	8616-8619	DT	denotes	the
T2892	8629-8638	NNS	denotes	fractions
T2893	8620-8628	NN	denotes	gradient
T2894	8639-8644	WRB	denotes	where
T2895	8654-8661	VBN	denotes	assumed
T2896	8645-8649	PRP	denotes	they
T2897	8650-8653	VBP	denotes	are
T2898	8662-8664	TO	denotes	to
T2899	8668-8678	VBN	denotes	associated
T2900	8665-8667	VB	denotes	be
T2901	8679-8683	IN	denotes	with
T2902	8684-8693	NNS	denotes	membranes
T2903	8693-8694	.	denotes	.
T2904	8694-8790	sentence	denotes	These membranes are exclusively plasma membranes as red blood cells are free of any organelles.
T2905	8695-8700	DT	denotes	These
T2906	8701-8710	NNS	denotes	membranes
T2907	8711-8714	VBP	denotes	are
T2908	8715-8726	RB	denotes	exclusively
T2909	8727-8733	NN	denotes	plasma
T2910	8734-8743	NNS	denotes	membranes
T2911	8744-8746	IN	denotes	as
T2912	8763-8766	VBP	denotes	are
T2913	8747-8750	JJ	denotes	red
T2914	8757-8762	NNS	denotes	cells
T2915	8751-8756	NN	denotes	blood
T2916	8767-8771	JJ	denotes	free
T2917	8772-8774	IN	denotes	of
T2918	8775-8778	DT	denotes	any
T2919	8779-8789	NNS	denotes	organelles
T2920	8789-8790	.	denotes	.
T2921	8790-8860	sentence	denotes	The distribution was however not homogeneous throughout the gradient.
T2922	8791-8794	DT	denotes	The
T2923	8795-8807	NN	denotes	distribution
T2924	8808-8811	VBD	denotes	was
T2925	8812-8819	RB	denotes	however
T2926	8820-8823	RB	denotes	not
T2927	8824-8835	JJ	denotes	homogeneous
T2928	8836-8846	IN	denotes	throughout
T2929	8847-8850	DT	denotes	the
T2930	8851-8859	NN	denotes	gradient
T2931	8859-8860	.	denotes	.
T2932	8860-9018	sentence	denotes	This could reflect the binding of annexin A7 to membrane subdomains that have different lipid or lipid/protein composition as discussed by Salzer et al. [7].
T2933	8861-8865	DT	denotes	This
T2934	8872-8879	VB	denotes	reflect
T2935	8866-8871	MD	denotes	could
T2936	8880-8883	DT	denotes	the
T2937	8884-8891	NN	denotes	binding
T2938	8892-8894	IN	denotes	of
T2939	8895-8902	NN	denotes	annexin
T2940	8903-8905	NN	denotes	A7
T2941	8906-8908	IN	denotes	to
T2942	8909-8917	NN	denotes	membrane
T2943	8918-8928	NNS	denotes	subdomains
T2944	8929-8933	WDT	denotes	that
T2945	8934-8938	VBP	denotes	have
T2946	8939-8948	JJ	denotes	different
T2947	8972-8983	NN	denotes	composition
T2948	8949-8954	NN	denotes	lipid
T2949	8955-8957	CC	denotes	or
T2950	8958-8963	NN	denotes	lipid
T2951	8964-8971	NN	denotes	protein
T2952	8963-8964	HYPH	denotes	/
T2953	8984-8986	IN	denotes	as
T2954	8987-8996	VBN	denotes	discussed
T2955	8997-8999	IN	denotes	by
T2956	9000-9006	NNP	denotes	Salzer
T2957	9007-9009	FW	denotes	et
T2958	9010-9013	FW	denotes	al.
T2959	9014-9015	-LRB-	denotes	[
T2960	9015-9016	CD	denotes	7
T2961	9016-9017	-RRB-	denotes	]
T2962	9017-9018	.	denotes	.
T2963	9018-9096	sentence	denotes	Likewise, sorcin does not exhibit a homogeneous distribution in the gradient.
T2964	9019-9027	RB	denotes	Likewise
T2965	9045-9052	VB	denotes	exhibit
T2966	9027-9029	,	denotes	,
T2967	9029-9035	NN	denotes	sorcin
T2968	9036-9040	VBZ	denotes	does
T2969	9041-9044	RB	denotes	not
T2970	9053-9054	DT	denotes	a
T2971	9067-9079	NN	denotes	distribution
T2972	9055-9066	JJ	denotes	homogeneous
T2973	9080-9082	IN	denotes	in
T2974	9083-9086	DT	denotes	the
T2975	9087-9095	NN	denotes	gradient
T2976	9095-9096	.	denotes	.
T2977	9096-9185	sentence	denotes	Moreover, it segregates into vesicles which are not associated with annexin A7 (Fig. 3).
T2978	9097-9105	RB	denotes	Moreover
T2979	9110-9120	VBZ	denotes	segregates
T2980	9105-9107	,	denotes	,
T2981	9107-9109	PRP	denotes	it
T2982	9121-9125	IN	denotes	into
T2983	9126-9134	NNS	denotes	vesicles
T2984	9135-9140	WDT	denotes	which
T2985	9149-9159	VBN	denotes	associated
T2986	9141-9144	VBP	denotes	are
T2987	9145-9148	RB	denotes	not
T2988	9160-9164	IN	denotes	with
T2989	9165-9172	NN	denotes	annexin
T2990	9173-9175	NN	denotes	A7
T2991	9176-9177	-LRB-	denotes	(
T2992	9177-9181	NN	denotes	Fig.
T2993	9182-9183	CD	denotes	3
T2994	9183-9184	-RRB-	denotes	)
T2995	9184-9185	.	denotes	.
T2996	9185-9278	sentence	denotes	We also tested platelets for annexin A7 expression and detected the 47 kDa isoform (Fig. 1).
T2997	9186-9188	PRP	denotes	We
T2998	9194-9200	VBD	denotes	tested
T2999	9189-9193	RB	denotes	also
T3000	9201-9210	NNS	denotes	platelets
T3001	9211-9214	IN	denotes	for
T3002	9215-9222	NN	denotes	annexin
T3003	9223-9225	NN	denotes	A7
T3004	9226-9236	NN	denotes	expression
T3005	9237-9240	CC	denotes	and
T3006	9241-9249	VBD	denotes	detected
T3007	9250-9253	DT	denotes	the
T3008	9261-9268	NN	denotes	isoform
T3009	9254-9256	CD	denotes	47
T3010	9257-9260	NN	denotes	kDa
T3011	9269-9270	-LRB-	denotes	(
T3012	9270-9274	NN	denotes	Fig.
T3013	9275-9276	CD	denotes	1
T3014	9276-9277	-RRB-	denotes	)
T3015	9277-9278	.	denotes	.
T3280	9646-9649	DT	denotes	The
T3281	9650-9654	NN	denotes	lack
T3282	9669-9676	VBZ	denotes	changes
T3283	9655-9657	IN	denotes	of
T3284	9658-9665	NN	denotes	annexin
T3285	9666-9668	NN	denotes	A7
T3286	9677-9680	JJ	denotes	red
T3287	9687-9691	NN	denotes	cell
T3288	9681-9686	NN	denotes	blood
T3289	9692-9702	NN	denotes	morphology
T3290	9703-9706	CC	denotes	and
T3291	9707-9714	JJ	denotes	osmotic
T3292	9715-9725	NN	denotes	resistance
T3293	9725-9911	sentence	denotes	As annexin A7 is a component of red blood cell vesicles we studied the consequences of the loss of the protein in the anxA7-/-mouse for red blood cell morphology and osmotic resistance.
T3294	9726-9728	IN	denotes	As
T3295	9740-9742	VBZ	denotes	is
T3296	9729-9736	NN	denotes	annexin
T3297	9737-9739	NN	denotes	A7
T3298	9785-9792	VBD	denotes	studied
T3299	9743-9744	DT	denotes	a
T3300	9745-9754	NN	denotes	component
T3301	9755-9757	IN	denotes	of
T3302	9758-9761	JJ	denotes	red
T3303	9768-9772	NN	denotes	cell
T3304	9762-9767	NN	denotes	blood
T3305	9773-9781	NNS	denotes	vesicles
T3306	9782-9784	PRP	denotes	we
T3307	9793-9796	DT	denotes	the
T3308	9797-9809	NNS	denotes	consequences
T3309	9810-9812	IN	denotes	of
T3310	9813-9816	DT	denotes	the
T3311	9817-9821	NN	denotes	loss
T3312	9822-9824	IN	denotes	of
T3313	9825-9828	DT	denotes	the
T3314	9829-9836	NN	denotes	protein
T3315	9837-9839	IN	denotes	in
T3316	9840-9843	DT	denotes	the
T3317	9852-9857	NN	denotes	mouse
T3318	9844-9849	NN	denotes	anxA7
T3319	9849-9850	SYM	denotes	-
T3320	9850-9851	HYPH	denotes	/
T3321	9851-9852	SYM	denotes	-
T3322	9858-9861	IN	denotes	for
T3323	9862-9865	JJ	denotes	red
T3324	9872-9876	NN	denotes	cell
T3325	9866-9871	NN	denotes	blood
T3326	9877-9887	NN	denotes	morphology
T3327	9888-9891	CC	denotes	and
T3328	9892-9899	JJ	denotes	osmotic
T3329	9900-9910	NN	denotes	resistance
T3330	9910-9911	.	denotes	.
T3331	9911-10084	sentence	denotes	In a standard 'blood smear' we did not note a deformation of the cells, however dark field microscopy revealed changes in shape and diameter of the anxA7-/-red blood cells.
T3332	9912-9914	IN	denotes	In
T3333	10014-10022	VBD	denotes	revealed
T3334	9915-9916	DT	denotes	a
T3335	9933-9938	NN	denotes	smear
T3336	9917-9925	JJ	denotes	standard
T3337	9926-9927	``	denotes	'
T3338	9927-9932	NN	denotes	blood
T3339	9938-9939	''	denotes	'
T3340	9940-9942	PRP	denotes	we
T3341	9951-9955	VB	denotes	note
T3342	9943-9946	VBD	denotes	did
T3343	9947-9950	RB	denotes	not
T3344	9956-9957	DT	denotes	a
T3345	9958-9969	NN	denotes	deformation
T3346	9970-9972	IN	denotes	of
T3347	9973-9976	DT	denotes	the
T3348	9977-9982	NNS	denotes	cells
T3349	9982-9984	,	denotes	,
T3350	9984-9991	RB	denotes	however
T3351	9992-9996	JJ	denotes	dark
T3352	9997-10002	NN	denotes	field
T3353	10003-10013	NN	denotes	microscopy
T3354	10023-10030	NNS	denotes	changes
T3355	10031-10033	IN	denotes	in
T3382	10162-10164	IN	denotes	to
T3383	10165-10169	JJ	denotes	wild
T3384	10170-10174	NN	denotes	type
T3385	10175-10179	IN	denotes	with
T3386	10180-10183	CD	denotes	5.7
T3387	10184-10186	NNS	denotes	μm
T3388	10187-10188	-LRB-	denotes	(
T3389	10203-10205	CD	denotes	40
T3390	10188-10189	NN	denotes	p
T3391	10192-10197	CD	denotes	0.015
T3392	10190-10191	SYM	denotes	=
T3393	10197-10199	,	denotes	,
T3394	10199-10200	NN	denotes	n
T3395	10201-10202	SYM	denotes	=
T3396	10205-10206	-RRB-	denotes	)
T3397	10206-10208	,	denotes	,
T3398	10208-10209	DT	denotes	a
T3399	10246-10256	NN	denotes	impression
T3400	10210-10220	RB	denotes	remarkably
T3401	10221-10226	JJR	denotes	lower
T3402	10227-10237	VBN	denotes	emphasized
T3403	10238-10245	JJ	denotes	central
T3404	10257-10260	CC	denotes	and
T3405	10261-10262	DT	denotes	a
T3406	10273-10278	NN	denotes	shape
T3407	10263-10267	RBR	denotes	more
T3408	10268-10272	JJ	denotes	flat
T3409	10279-10280	-LRB-	denotes	(
T3410	10280-10284	NN	denotes	Fig.
T3411	10285-10286	CD	denotes	4
T3412	10286-10287	-RRB-	denotes	)
T3413	10287-10288	.	denotes	.
T3414	10288-10393	sentence	denotes	No significant change in the mean corpuscular volume (MCV) was measured with the ADVIA 120 cell counter.
T3415	10289-10291	DT	denotes	No
T3416	10304-10310	NN	denotes	change
T3417	10292-10303	JJ	denotes	significant
T3418	10352-10360	VBN	denotes	measured
T3419	10311-10313	IN	denotes	in
T3420	10314-10317	DT	denotes	the
T3421	10335-10341	NN	denotes	volume
T3422	10318-10322	JJ	denotes	mean
T3423	10323-10334	JJ	denotes	corpuscular
T3424	10342-10343	-LRB-	denotes	(
T3425	10343-10346	NN	denotes	MCV
T3426	10346-10347	-RRB-	denotes	)
T3427	10348-10351	VBD	denotes	was
T3428	10361-10365	IN	denotes	with
T3429	10366-10369	DT	denotes	the
T3430	10385-10392	NN	denotes	counter
T3431	10370-10375	NN	denotes	ADVIA
T3432	10376-10379	CD	denotes	120
T3433	10380-10384	NN	denotes	cell
T3434	10392-10393	.	denotes	.
T3435	10393-10394	sentence	denotes
T3475	10895-10899	VB	denotes	play
T3476	10878-10885	NN	denotes	annexin
T3477	10886-10888	NN	denotes	A7
T3478	10889-10894	MD	denotes	might
T3479	10900-10901	DT	denotes	a
T3480	10902-10906	NN	denotes	role
T3481	10906-10907	.	denotes	.
T3482	10907-11076	sentence	denotes	The osmotic resistance, which is the resistance towards changes in the extracellular ionic strength, is a convenient assay for analysis of the red blood cell integrity.
T3483	10908-10911	DT	denotes	The
T3484	10920-10930	NN	denotes	resistance
T3485	10912-10919	JJ	denotes	osmotic
T3486	11009-11011	VBZ	denotes	is
T3487	10930-10932	,	denotes	,
T3488	10932-10937	WDT	denotes	which
T3489	10938-10940	VBZ	denotes	is
T3490	10941-10944	DT	denotes	the
T3491	10945-10955	NN	denotes	resistance
T3492	10956-10963	IN	denotes	towards
T3493	10964-10971	NNS	denotes	changes
T3494	10972-10974	IN	denotes	in
T3495	10975-10978	DT	denotes	the
T3496	10999-11007	NN	denotes	strength
T3497	10979-10992	JJ	denotes	extracellular
T3498	10993-10998	JJ	denotes	ionic
T3499	11007-11009	,	denotes	,
T3500	11012-11013	DT	denotes	a
T3501	11025-11030	NN	denotes	assay
T3502	11014-11024	JJ	denotes	convenient
T3503	11031-11034	IN	denotes	for
T3504	11035-11043	NN	denotes	analysis
T3505	11044-11046	IN	denotes	of
T3506	11047-11050	DT	denotes	the
T3507	11066-11075	NN	denotes	integrity
T3508	11051-11054	JJ	denotes	red
T3509	11061-11065	NN	denotes	cell
T3510	11055-11060	NN	denotes	blood
T3511	11075-11076	.	denotes	.
T3512	11076-11243	sentence	denotes	It is measured as the sodium chloride concentration at which cellular lysis starts (minimal resistance) up to a complete lysis (maximal resistance) of the cells [33].
T3513	11077-11079	PRP	denotes	It
T3514	11083-11091	VBN	denotes	measured
T3515	11080-11082	VBZ	denotes	is
T3516	11092-11094	IN	denotes	as
T3517	11095-11098	DT	denotes	the
T3518	11115-11128	NN	denotes	concentration
T3519	11099-11105	NN	denotes	sodium
T3520	11106-11114	NN	denotes	chloride
T3521	11129-11131	IN	denotes	at
T3522	11153-11159	VBZ	denotes	starts
T3523	11132-11137	WDT	denotes	which
T3524	11138-11146	JJ	denotes	cellular
T3525	11147-11152	NN	denotes	lysis
T3526	11160-11161	-LRB-	denotes	(
T3527	11161-11168	JJ	denotes	minimal
T3528	11169-11179	NN	denotes	resistance
T3529	11179-11180	-RRB-	denotes	)
T3530	11181-11183	IN	denotes	up
T3531	11184-11186	IN	denotes	to
T3532	11187-11188	DT	denotes	a
T3533	11198-11203	NN	denotes	lysis
T3534	11189-11197	JJ	denotes	complete
T3535	11204-11205	-LRB-	denotes	(
T3536	11205-11212	JJ	denotes	maximal
T3537	11213-11223	NN	denotes	resistance
T3538	11223-11224	-RRB-	denotes	)
T3539	11225-11227	IN	denotes	of
T3540	11228-11231	DT	denotes	the
T3541	11232-11237	NNS	denotes	cells
T3542	11238-11239	-LRB-	denotes	[
T3543	11239-11241	CD	denotes	33
T3544	11241-11242	-RRB-	denotes	]
T3545	11242-11243	.	denotes	.
T3546	11243-11394	sentence	denotes	Osmotic resistance increases with higher MCV, larger surface area and a higher degree of cellular metabolism stabilizing the intracellular ion levels.
T3547	11244-11251	JJ	denotes	Osmotic
T3548	11252-11262	NN	denotes	resistance
T3549	11263-11272	VBZ	denotes	increases
T3550	11273-11277	IN	denotes	with
T3551	11278-11284	JJR	denotes	higher
T3552	11285-11288	NN	denotes	MCV
T3553	11288-11290	,	denotes	,
T3554	11290-11296	JJR	denotes	larger
T3555	11305-11309	NN	denotes	area
T3556	11297-11304	NN	denotes	surface
T3557	11310-11313	CC	denotes	and
T3558	11314-11315	DT	denotes	a
T3559	11323-11329	NN	denotes	degree
T3560	11316-11322	JJR	denotes	higher
T3561	11330-11332	IN	denotes	of
T3562	11333-11341	JJ	denotes	cellular
T3563	11342-11352	NN	denotes	metabolism
T3564	11353-11364	VBG	denotes	stabilizing
T3565	11365-11368	DT	denotes	the
T3566	11387-11393	NNS	denotes	levels
T3567	11369-11382	JJ	denotes	intracellular
T3568	11383-11386	NN	denotes	ion
T3569	11393-11394	.	denotes	.
T3570	11394-11469	sentence	denotes	Aged red blood cells show a lowered MCV and lower osmotic resistance [33].
T3571	11395-11399	VBN	denotes	Aged
T3572	11410-11415	NNS	denotes	cells
T3573	11400-11403	JJ	denotes	red
T3574	11404-11409	NN	denotes	blood
T3575	11416-11420	VBP	denotes	show
T3576	11421-11422	DT	denotes	a
T3577	11431-11434	NN	denotes	MCV
T3578	11423-11430	JJ	denotes	lowered
T3579	11435-11438	CC	denotes	and
T3580	11439-11444	JJR	denotes	lower
T3581	11453-11463	NN	denotes	resistance
T3582	11445-11452	JJ	denotes	osmotic
T3583	11464-11465	-LRB-	denotes	[
T3584	11465-11467	CD	denotes	33
T3585	11467-11468	-RRB-	denotes	]
T3586	11468-11469	.	denotes	.
T3587	11469-11559	sentence	denotes	Similar properties can be observed in red blood cells with lowered membrane permeability.
T3588	11470-11477	JJ	denotes	Similar
T3589	11478-11488	NNS	denotes	properties
T3590	11496-11504	VBN	denotes	observed
T3591	11489-11492	MD	denotes	can
T3592	11493-11495	VB	denotes	be
T3593	11505-11507	IN	denotes	in
T3594	11508-11511	JJ	denotes	red
T3595	11518-11523	NNS	denotes	cells
T3596	11512-11517	NN	denotes	blood
T3597	11524-11528	IN	denotes	with
T3598	11529-11536	VBN	denotes	lowered
T3599	11546-11558	NN	denotes	permeability
T3600	11537-11545	NN	denotes	membrane
T3601	11558-11559	.	denotes	.
T3602	11559-11678	sentence	denotes	The osmotic resistance of annexin A7 deficient red blood cells is significantly increased compared to wild type cells.
T3603	11560-11563	DT	denotes	The
T3604	11572-11582	NN	denotes	resistance
T3605	11564-11571	JJ	denotes	osmotic
T3606	11623-11625	VBZ	denotes	is
T3607	11583-11585	IN	denotes	of
T3608	11586-11593	NN	denotes	annexin
T3609	11594-11596	NN	denotes	A7
T3610	11597-11606	JJ	denotes	deficient
T3611	11617-11622	NNS	denotes	cells
T3612	11607-11610	JJ	denotes	red
T3613	11611-11616	NN	denotes	blood
T3614	11626-11639	RB	denotes	significantly
T3615	11640-11649	VBN	denotes	increased
T3616	11650-11658	VBN	denotes	compared
T3617	11659-11661	IN	denotes	to
T3618	11662-11666	JJ	denotes	wild
T3619	11667-11671	NN	denotes	type
T3620	11672-11677	NNS	denotes	cells
T3621	11677-11678	.	denotes	.
T3622	11678-11799	sentence	denotes	The minimal resistance value of knock out cells is observed in a 0.60 % NaCl solution versus 0.65 % for wild type cells.
T3623	11679-11682	DT	denotes	The
T3624	11702-11707	NN	denotes	value
T3625	11683-11690	JJ	denotes	minimal
T3626	11691-11701	NN	denotes	resistance
T3627	11730-11738	VBN	denotes	observed
T3628	11708-11710	IN	denotes	of
T3629	11711-11716	NN	denotes	knock
T3630	11717-11720	NN	denotes	out
T3631	11721-11726	NNS	denotes	cells
T3632	11727-11729	VBZ	denotes	is
T3633	11739-11741	IN	denotes	in
T3634	11742-11743	DT	denotes	a
T3635	11756-11764	NN	denotes	solution
T3636	11744-11748	CD	denotes	0.60
T3637	11749-11750	NN	denotes	%
T3638	11751-11755	NN	denotes	NaCl
T3639	11765-11771	CC	denotes	versus
T3640	11772-11776	CD	denotes	0.65
T3641	11777-11778	NN	denotes	%
T3642	11779-11782	IN	denotes	for
T3643	11783-11787	JJ	denotes	wild
T3644	11788-11792	NN	denotes	type
T3645	11793-11798	NNS	denotes	cells
T3646	11798-11799	.	denotes	.
T3647	11799-11949	sentence	denotes	50 % haemolysis is achieved at 0.516 % NaCl solution for knock out versus 0.564 % NaCl for wild type cells (mean values, p = 0.00066, n = 8; Fig. 5).
T3648	11800-11802	CD	denotes	50
T3649	11803-11804	NN	denotes	%
T3650	11805-11815	NN	denotes	haemolysis
T3651	11819-11827	VBN	denotes	achieved
T3652	11816-11818	VBZ	denotes	is
T3653	11828-11830	IN	denotes	at
T3654	11831-11836	CD	denotes	0.516
T3655	11837-11838	NN	denotes	%
T3656	11844-11852	NN	denotes	solution
T3657	11839-11843	NN	denotes	NaCl
T3658	11853-11856	IN	denotes	for
T3659	11857-11862	NN	denotes	knock
T3660	11863-11866	NN	denotes	out
T3661	11867-11873	CC	denotes	versus
T3662	11874-11879	CD	denotes	0.564
T3663	11880-11881	NN	denotes	%
T3664	11882-11886	NN	denotes	NaCl
T3665	11887-11890	IN	denotes	for
T3666	11891-11895	JJ	denotes	wild
T3667	11896-11900	NN	denotes	type
T3668	11901-11906	NNS	denotes	cells
T3669	11907-11908	-LRB-	denotes	(
T3670	11941-11945	NN	denotes	Fig.
T3671	11908-11912	NN	denotes	mean
T3672	11913-11919	NNS	denotes	values
T3673	11919-11921	,	denotes	,
T3674	11921-11922	NN	denotes	p
T3675	11925-11932	CD	denotes	0.00066
T3676	11923-11924	SYM	denotes	=
T3677	11932-11934	,	denotes	,
T3678	11934-11935	NN	denotes	n
T3679	11938-11939	CD	denotes	8
T3680	11936-11937	SYM	denotes	=
T3681	11939-11940	:	denotes	;
T3682	11946-11947	CD	denotes	5
T3683	11947-11948	-RRB-	denotes	)
T3684	11948-11949	.	denotes	.
T3685	11949-12053	sentence	denotes	The resistance width of the knock out cells is slightly lower (0.20 % instead of 0.25 % NaCl solution).
T3686	11950-11953	DT	denotes	The
T3687	11965-11970	NN	denotes	width
T3688	11954-11964	NN	denotes	resistance
T3689	11994-11996	VBZ	denotes	is
T3690	11971-11973	IN	denotes	of
T3691	11974-11977	DT	denotes	the
T3692	11988-11993	NNS	denotes	cells
T3693	11978-11983	NN	denotes	knock
T3694	11984-11987	NN	denotes	out
T3695	11997-12005	RB	denotes	slightly
T3696	12006-12011	JJR	denotes	lower
T3697	12012-12013	-LRB-	denotes	(
T3698	12043-12051	NN	denotes	solution
T3699	12013-12017	CD	denotes	0.20
T3700	12018-12019	NN	denotes	%
T3701	12038-12042	NN	denotes	NaCl
T3702	12020-12027	RB	denotes	instead
T3703	12028-12030	IN	denotes	of
T3704	12031-12035	CD	denotes	0.25
T3705	12036-12037	NN	denotes	%
T3706	12051-12052	-RRB-	denotes	)
T3707	12052-12053	.	denotes	.
T3708	12053-12218	sentence	denotes	We also performed direct measurements of the red blood cell membrane deformability, to further characterize a possible role of annexin A7 on the membrane stability.
T3709	12054-12056	PRP	denotes	We
T3710	12062-12071	VBD	denotes	performed
T3711	12057-12061	RB	denotes	also
T3712	12072-12078	JJ	denotes	direct
T3713	12079-12091	NNS	denotes	measurements
T3714	12092-12094	IN	denotes	of
T3718	12109-12113	NN	denotes	cell
T3719	12103-12108	NN	denotes	blood
T3720	12114-12122	NN	denotes	membrane
T3721	12136-12138	,	denotes	,
T3722	12138-12140	TO	denotes	to
T3723	12149-12161	VB	denotes	characterize
T3724	12141-12148	RBR	denotes	further
T3725	12162-12163	DT	denotes	a
T3726	12173-12177	NN	denotes	role
T3727	12164-12172	JJ	denotes	possible
T3728	12178-12180	IN	denotes	of
T3729	12181-12188	NN	denotes	annexin
T3730	12189-12191	NN	denotes	A7
T3731	12192-12194	IN	denotes	on
T3732	12195-12198	DT	denotes	the
T3733	12208-12217	NN	denotes	stability
T3734	12199-12207	NN	denotes	membrane
T3735	12217-12218	.	denotes	.
T3736	12218-12343	sentence	denotes	With micropipette experiments we tried to correlate mechanical characteristics of the red blood cells with their morphology.
T3737	12219-12223	IN	denotes	With
T3738	12252-12257	VBD	denotes	tried
T3739	12224-12236	NN	denotes	micropipette
T3740	12237-12248	NNS	denotes	experiments
T3741	12249-12251	PRP	denotes	we
T3742	12258-12260	TO	denotes	to
T3743	12261-12270	VB	denotes	correlate
T3744	12271-12281	JJ	denotes	mechanical
T3745	12282-12297	NNS	denotes	characteristics
T3746	12298-12300	IN	denotes	of
T3747	12301-12304	DT	denotes	the
T3748	12315-12320	NNS	denotes	cells
T3749	12305-12308	JJ	denotes	red
T3750	12309-12314	NN	denotes	blood
T3751	12321-12325	IN	denotes	with
T3752	12326-12331	PRP$	denotes	their
T3753	12332-12342	NN	denotes	morphology
T3754	12342-12343	.	denotes	.
T3755	12343-12540	sentence	denotes	We could not observe any statistically significant difference of values describing membrane rigidity and lysis force in these experiments (M. Heil, B. Hoffmann and R. Merkel, unpublished results).
T3756	12344-12346	PRP	denotes	We
T3757	12357-12364	VB	denotes	observe
T3758	12347-12352	MD	denotes	could
T3759	12353-12356	RB	denotes	not
T3760	12365-12368	DT	denotes	any
T3761	12395-12405	NN	denotes	difference
T3762	12369-12382	RB	denotes	statistically
T3763	12383-12394	JJ	denotes	significant
T3764	12406-12408	IN	denotes	of
T3765	12409-12415	NNS	denotes	values
T3766	12416-12426	VBG	denotes	describing
T3767	12427-12435	NN	denotes	membrane
T3768	12436-12444	NN	denotes	rigidity
T3769	12445-12448	CC	denotes	and
T3770	12449-12454	NN	denotes	lysis
T3771	12455-12460	NN	denotes	force
T3772	12461-12463	IN	denotes	in
T3773	12464-12469	DT	denotes	these
T3774	12470-12481	NNS	denotes	experiments
T3775	12482-12483	-LRB-	denotes	(
T3776	12483-12485	NNP	denotes	M.
T3777	12486-12490	NNP	denotes	Heil
T3778	12490-12492	,	denotes	,
T3779	12492-12494	NNP	denotes	B.
T3780	12495-12503	NNP	denotes	Hoffmann
T3781	12504-12507	CC	denotes	and
T3782	12508-12510	NNP	denotes	R.
T3783	12511-12517	NNP	denotes	Merkel
T3784	12517-12519	,	denotes	,
T3785	12519-12530	JJ	denotes	unpublished
T3786	12531-12538	NNS	denotes	results
T3787	12538-12539	-RRB-	denotes	)
T3788	12539-12540	.	denotes	.
T3789	12540-12710	sentence	denotes	However, the distinction observed in the osmotic resistance experiments was highly significant and reflects a mean value over a high number of different red blood cells.
T3790	12541-12548	RB	denotes	However
T3791	12613-12616	VBD	denotes	was
T3792	12548-12550	,	denotes	,
T3793	12550-12553	DT	denotes	the
T3794	12554-12565	NN	denotes	distinction
T3795	12566-12574	VBN	denotes	observed
T3796	12575-12577	IN	denotes	in
T3797	12578-12581	DT	denotes	the
T3798	12601-12612	NNS	denotes	experiments
T3799	12582-12589	JJ	denotes	osmotic
T3800	12590-12600	NN	denotes	resistance
T3801	12617-12623	RB	denotes	highly
T3802	12624-12635	JJ	denotes	significant
T3803	12636-12639	CC	denotes	and
T3804	12640-12648	VBZ	denotes	reflects
T3805	12649-12650	DT	denotes	a
T3806	12656-12661	NN	denotes	value
T3807	12651-12655	JJ	denotes	mean
T3808	12662-12666	IN	denotes	over
T3809	12667-12668	DT	denotes	a
T3810	12674-12680	NN	denotes	number
T3811	12669-12673	JJ	denotes	high
T3812	12681-12683	IN	denotes	of
T3813	12684-12693	JJ	denotes	different
T3814	12704-12709	NNS	denotes	cells
T3815	12694-12697	JJ	denotes	red
T3816	12698-12703	NN	denotes	blood
T3817	12709-12710	.	denotes	.
T3818	12710-13368	sentence	denotes	Figure 5 Osmotic resistance curves of red blood cells from wild type and anxA7-/- mutant mice. The osmotic resistance towards changes in the extracellular ionic strength is a convenient assay for analysis of the red blood cell integrity. It is measured as a sodium chloride concentration in which cellular lysis starts (minimal resistance) up to a complete lysis (maximal resistance) of a red blood cell. The osmotic resistance of annexin A7 deficient red blood cells is significantly increased compared to the one of wild type (p = 0.00066; n = 8). These data suggest that annexin A7 contributes to the shape of red blood cells and the osmotic resistance.
T3819	13262-13267	DT	denotes	These
T3820	13268-13272	NNS	denotes	data
T3821	13273-13280	VBP	denotes	suggest
T3822	13281-13285	IN	denotes	that
T3823	13297-13308	VBZ	denotes	contributes
T3824	13286-13293	NN	denotes	annexin
T3825	13294-13296	NN	denotes	A7
T3826	13309-13311	IN	denotes	to
T3827	13312-13315	DT	denotes	the
T3828	13316-13321	NN	denotes	shape
T3829	13322-13324	IN	denotes	of
T3830	13325-13328	JJ	denotes	red
T3831	13335-13340	NNS	denotes	cells
T3832	13329-13334	NN	denotes	blood
T3833	13341-13344	CC	denotes	and
T3834	13345-13348	DT	denotes	the
T3835	13357-13367	NN	denotes	resistance
T3836	13349-13356	JJ	denotes	osmotic
T3837	13367-13368	.	denotes	.
T3838	13368-13546	sentence	denotes	As we have not observed a binding of annexin A7 to F-actin (data not shown) it could do so either by alteration of the membrane rigidity and/or by affecting the ion homeostasis.
T3839	13369-13371	IN	denotes	As
T3840	13384-13392	VBN	denotes	observed
T3841	13372-13374	PRP	denotes	we
T3842	13375-13379	VBP	denotes	have
T3843	13380-13383	RB	denotes	not
T3844	13454-13456	VB	denotes	do
T3845	13393-13394	DT	denotes	a
T3846	13395-13402	NN	denotes	binding
T3847	13403-13405	IN	denotes	of
T3848	13406-13413	NN	denotes	annexin
T3849	13414-13416	NN	denotes	A7
T3850	13417-13419	IN	denotes	to
T3851	13420-13421	NN	denotes	F
T3852	13422-13427	NN	denotes	actin
T3853	13421-13422	HYPH	denotes	-
T3854	13428-13429	-LRB-	denotes	(
T3855	13438-13443	VBN	denotes	shown
T3856	13429-13433	NNS	denotes	data
T3857	13434-13437	RB	denotes	not
T3858	13443-13444	-RRB-	denotes	)
T3859	13445-13447	PRP	denotes	it
T3860	13448-13453	MD	denotes	could
T3861	13457-13459	RB	denotes	so
T3862	13460-13466	CC	denotes	either
T3863	13467-13469	IN	denotes	by
T3864	13470-13480	NN	denotes	alteration
T3865	13481-13483	IN	denotes	of
T3866	13484-13487	DT	denotes	the
T3867	13497-13505	NN	denotes	rigidity
T3868	13488-13496	NN	denotes	membrane
T3869	13506-13509	CC	denotes	and
T3870	13509-13510	HYPH	denotes	/
T3871	13510-13512	CC	denotes	or
T3872	13513-13515	IN	denotes	by
T3873	13516-13525	VBG	denotes	affecting
T3874	13526-13529	DT	denotes	the
T3875	13534-13545	NN	denotes	homeostasis
T3876	13530-13533	NN	denotes	ion
T3877	13545-13546	.	denotes	.
T4078	13548-13551	DT	denotes	The
T4079	13552-13556	NN	denotes	lack
T4080	13571-13578	VBZ	denotes	affects
T4081	13557-13559	IN	denotes	of
T4082	13560-13567	NN	denotes	annexin
T4083	13568-13570	NN	denotes	A7
T4084	13579-13586	JJ	denotes	primary
T4085	13587-13598	NN	denotes	haemostasis
T4086	13599-13601	FW	denotes	ex
T4087	13602-13606	FW	denotes	vivo
T4088	13606-13770	sentence	denotes	The use of an advanced electronic cell counter/flow cytometer (ADVIA 120) allowed us to screen other parameters as well despite of the limited murine blood volume.
T4089	13607-13610	DT	denotes	The
T4090	13611-13614	NN	denotes	use
T4091	13681-13688	VBD	denotes	allowed
T4092	13615-13617	IN	denotes	of
T4093	13618-13620	DT	denotes	an
T4094	13646-13653	NN	denotes	counter
T4095	13621-13629	JJ	denotes	advanced
T4096	13630-13640	JJ	denotes	electronic
T4097	13641-13645	NN	denotes	cell
T4098	13653-13654	HYPH	denotes	/
T4099	13654-13658	NN	denotes	flow
T4100	13659-13668	NN	denotes	cytometer
T4101	13669-13670	-LRB-	denotes	(
T4102	13670-13675	NN	denotes	ADVIA
T4103	13676-13679	CD	denotes	120
T4104	13679-13680	-RRB-	denotes	)
T4105	13689-13691	PRP	denotes	us
T4106	13695-13701	VB	denotes	screen
T4107	13692-13694	TO	denotes	to
T4108	13702-13707	JJ	denotes	other
T4109	13708-13718	NNS	denotes	parameters
T4110	13719-13721	RB	denotes	as
T4111	13722-13726	RB	denotes	well
T4112	13727-13734	IN	denotes	despite
T4113	13735-13737	IN	denotes	of
T4114	13738-13741	DT	denotes	the
T4115	13763-13769	NN	denotes	volume
T4116	13742-13749	JJ	denotes	limited
T4117	13750-13756	JJ	denotes	murine
T4118	13757-13762	NN	denotes	blood
T4119	13769-13770	.	denotes	.
T4120	13770-14013	sentence	denotes	We analysed leukocytes, red blood cells, haemoglobin content, haematocrit, mean cellular volume, mean cellular haemoglobin, mean cellular haemoglobin concentration, platelets, neutrophiles, lymphocytes, monocytes, eosinophiles and basophiles.
T4121	13771-13773	PRP	denotes	We
T4122	13774-13782	VBD	denotes	analysed
T4123	13783-13793	NNS	denotes	leukocytes
T4124	13793-13795	,	denotes	,
T4125	13795-13798	JJ	denotes	red
T4126	13805-13810	NNS	denotes	cells
T4127	13799-13804	NN	denotes	blood
T4128	13810-13812	,	denotes	,
T4129	13812-13823	NN	denotes	haemoglobin
T4130	13824-13831	NN	denotes	content
T4131	13831-13833	,	denotes	,
T4132	13833-13844	NN	denotes	haematocrit
T4133	13844-13846	,	denotes	,
T4134	13846-13850	JJ	denotes	mean
T4135	13860-13866	NN	denotes	volume
T4136	13851-13859	JJ	denotes	cellular
T4137	13866-13868	,	denotes	,
T4138	13868-13872	JJ	denotes	mean
T4139	13882-13893	NN	denotes	haemoglobin
T4140	13873-13881	JJ	denotes	cellular
T4141	13893-13895	,	denotes	,
T4142	13895-13899	JJ	denotes	mean
T4143	13909-13920	NN	denotes	haemoglobin
T4144	13900-13908	JJ	denotes	cellular
T4145	13921-13934	NN	denotes	concentration
T4146	13934-13936	,	denotes	,
T4147	13936-13945	NNS	denotes	platelets
T4148	13945-13947	,	denotes	,
T4149	13947-13959	NNS	denotes	neutrophiles
T4150	13959-13961	,	denotes	,
T4151	13961-13972	NNS	denotes	lymphocytes
T4152	13972-13974	,	denotes	,
T4153	13974-13983	NNS	denotes	monocytes
T4154	13983-13985	,	denotes	,
T4155	13985-13997	NNS	denotes	eosinophiles
T4156	13998-14001	CC	denotes	and
T4157	14002-14012	NNS	denotes	basophiles
T4158	14012-14013	.	denotes	.
T4159	14013-14154	sentence	denotes	In these tests of whole blood we found only a change in the platelet numbers, whereas all other haematological parameters were not affected.
T4160	14014-14016	IN	denotes	In
T4161	14047-14052	VBD	denotes	found
T4162	14017-14022	DT	denotes	these
T4163	14023-14028	NNS	denotes	tests
T4164	14029-14031	IN	denotes	of
T4165	14032-14037	JJ	denotes	whole
T4166	14038-14043	NN	denotes	blood
T4167	14044-14046	PRP	denotes	we
T4168	14053-14057	RB	denotes	only
T4169	14058-14059	DT	denotes	a
T4170	14060-14066	NN	denotes	change
T4171	14067-14069	IN	denotes	in
T4172	14070-14073	DT	denotes	the
T4173	14083-14090	NNS	denotes	numbers
T4174	14074-14082	NN	denotes	platelet
T4175	14090-14092	,	denotes	,
T4176	14092-14099	IN	denotes	whereas
T4177	14145-14153	VBN	denotes	affected
T4178	14100-14103	DT	denotes	all
T4179	14125-14135	NNS	denotes	parameters
T4180	14104-14109	JJ	denotes	other
T4181	14110-14124	JJ	denotes	haematological
T4182	14136-14140	VBD	denotes	were
T4183	14141-14144	RB	denotes	not
T4184	14153-14154	.	denotes	.
T4185	14154-14282	sentence	denotes	The mean platelet counts from wild type and anxA7-/- mutant mice are determined as 674 × 103/μl and 774 × 103/μl, respectively.
T4186	14155-14158	DT	denotes	The
T4187	14173-14179	NNS	denotes	counts
T4188	14159-14163	JJ	denotes	mean
T4189	14164-14172	NN	denotes	platelet
T4190	14224-14234	VBN	denotes	determined
T4191	14180-14184	IN	denotes	from
T4192	14185-14189	JJ	denotes	wild
T4193	14190-14194	NN	denotes	type
T4194	14215-14219	NNS	denotes	mice
T4195	14195-14198	CC	denotes	and
T4196	14199-14204	NN	denotes	anxA7
T4197	14204-14205	SYM	denotes	-
T4198	14205-14206	HYPH	denotes	/
T4199	14206-14207	SYM	denotes	-
T4200	14208-14214	JJ	denotes	mutant
T4201	14220-14223	VBP	denotes	are
T4202	14235-14237	IN	denotes	as
T4203	14238-14241	CD	denotes	674
T4204	14244-14247	CD	denotes	103
T4205	14242-14243	SYM	denotes	×
T4206	14247-14248	SYM	denotes	/
T4207	14248-14250	NNS	denotes	μl
T4208	14251-14254	CC	denotes	and
T4209	14255-14258	CD	denotes	774
T4210	14261-14264	CD	denotes	103
T4211	14259-14260	SYM	denotes	×
T4212	14264-14265	SYM	denotes	/
T4213	14265-14267	NNS	denotes	μl
T4214	14267-14269	,	denotes	,
T4215	14269-14281	RB	denotes	respectively
T4216	14281-14282	.	denotes	.
T4217	14282-14395	sentence	denotes	The platelet counts in knock out mice are significantly higher (p = 0.0275; n knock out = 11, n wild type = 14).
T4218	14283-14286	DT	denotes	The
T4219	14296-14302	NNS	denotes	counts
T4220	14287-14295	NN	denotes	platelet
T4221	14321-14324	VBP	denotes	are
T4222	14303-14305	IN	denotes	in
T4223	14306-14311	NN	denotes	knock
T4224	14312-14315	NN	denotes	out
T4225	14316-14320	NNS	denotes	mice
T4226	14325-14338	RB	denotes	significantly
T4227	14339-14345	JJR	denotes	higher
T4228	14346-14347	-LRB-	denotes	(
T4229	14391-14393	CD	denotes	14
T4230	14347-14348	NN	denotes	p
T4231	14351-14357	CD	denotes	0.0275
T4232	14349-14350	SYM	denotes	=
T4233	14357-14358	:	denotes	;
T4234	14359-14360	NN	denotes	n
T4235	14367-14370	NN	denotes	out
T4236	14361-14366	NN	denotes	knock
T4237	14373-14375	CD	denotes	11
T4238	14371-14372	SYM	denotes	=
T4239	14375-14377	,	denotes	,
T4240	14377-14378	NN	denotes	n
T4241	14384-14388	NN	denotes	type
T4242	14379-14383	JJ	denotes	wild
T4243	14389-14390	SYM	denotes	=
T4244	14393-14394	-RRB-	denotes	)
T4245	14394-14395	.	denotes	.
T4246	14395-14457	sentence	denotes	An increase in platelet counts is a rather uncommon disorder.
T4247	14396-14398	DT	denotes	An
T4248	14399-14407	NN	denotes	increase
T4249	14427-14429	VBZ	denotes	is
T4250	14408-14410	IN	denotes	in
T4251	14411-14419	NN	denotes	platelet
T4252	14420-14426	NNS	denotes	counts
T4253	14430-14431	DT	denotes	a
T4254	14448-14456	NN	denotes	disorder
T4255	14432-14438	RB	denotes	rather
T4256	14439-14447	JJ	denotes	uncommon
T4257	14456-14457	.	denotes	.
T4258	14457-14633	sentence	denotes	In humans, platelet counts normally increase only transiently as in reactive thrombocytosis and under postoperative conditions or are largely increased in neoplastic diseases.
T4259	14458-14460	IN	denotes	In
T4260	14494-14502	VBP	denotes	increase
T4261	14461-14467	NNS	denotes	humans
T4262	14467-14469	,	denotes	,
T4263	14469-14477	NN	denotes	platelet
T4264	14478-14484	NNS	denotes	counts
T4265	14485-14493	RB	denotes	normally
T4266	14503-14507	RB	denotes	only
T4267	14508-14519	RB	denotes	transiently
T4268	14520-14522	IN	denotes	as
T4269	14523-14525	IN	denotes	in
T4270	14526-14534	JJ	denotes	reactive
T4271	14535-14549	NN	denotes	thrombocytosis
T4272	14550-14553	CC	denotes	and
T4273	14554-14559	IN	denotes	under
T4274	14560-14573	JJ	denotes	postoperative
T4275	14574-14584	NNS	denotes	conditions
T4276	14585-14587	CC	denotes	or
T4277	14588-14591	VBP	denotes	are
T4278	14600-14609	VBN	denotes	increased
T4279	14592-14599	RB	denotes	largely
T4280	14610-14612	IN	denotes	in
T4281	14613-14623	JJ	denotes	neoplastic
T4282	14624-14632	NNS	denotes	diseases
T4283	14632-14633	.	denotes	.
T4284	14633-14687	sentence	denotes	By contrast, the anxA7-/-mice are healthy and viable.
T4285	14634-14636	IN	denotes	By
T4286	14664-14667	VBP	denotes	are
T4287	14637-14645	NN	denotes	contrast
T4288	14645-14647	,	denotes	,
T4289	14647-14650	DT	denotes	the
T4290	14659-14663	NNS	denotes	mice
T4291	14651-14656	NN	denotes	anxA7
T4292	14656-14657	SYM	denotes	-
T4293	14657-14658	HYPH	denotes	/
T4294	14658-14659	SYM	denotes	-
T4295	14668-14675	JJ	denotes	healthy
T4296	14676-14679	CC	denotes	and
T4297	14680-14686	JJ	denotes	viable
T4298	14686-14687	.	denotes	.
T4299	14687-14796	sentence	denotes	Therefore we tested the platelet function and performed aggregometry measurements with platelet rich plasma.
T4300	14688-14697	RB	denotes	Therefore
T4301	14701-14707	VBD	denotes	tested
T4302	14698-14700	PRP	denotes	we
T4303	14708-14711	DT	denotes	the
T4304	14721-14729	NN	denotes	function
T4305	14712-14720	NN	denotes	platelet
T4306	14730-14733	CC	denotes	and
T4307	14734-14743	VBD	denotes	performed
T4308	14744-14756	NN	denotes	aggregometry
T4309	14757-14769	NNS	denotes	measurements
T4310	14770-14774	IN	denotes	with
T4311	14775-14783	NN	denotes	platelet
T4312	14784-14788	JJ	denotes	rich
T4313	14789-14795	NN	denotes	plasma
T4314	14795-14796	.	denotes	.
T4315	14796-14931	sentence	denotes	Platelet activation is observed as a morphological change from the resting discoid state to activated spherical cells with pseudopods.
T4316	14797-14805	NN	denotes	Platelet
T4317	14806-14816	NN	denotes	activation
T4318	14820-14828	VBN	denotes	observed
T4319	14817-14819	VBZ	denotes	is
T4320	14829-14831	IN	denotes	as
T4321	14832-14833	DT	denotes	a
T4322	14848-14854	NN	denotes	change
T4323	14834-14847	JJ	denotes	morphological
T4324	14855-14859	IN	denotes	from
T4325	14860-14863	DT	denotes	the
T4326	14880-14885	NN	denotes	state
T4327	14864-14871	VBG	denotes	resting
T4328	14872-14879	JJ	denotes	discoid
T4329	14886-14888	IN	denotes	to
T4330	14889-14898	VBN	denotes	activated
T4331	14909-14914	NNS	denotes	cells
T4332	14899-14908	JJ	denotes	spherical
T4333	14915-14919	IN	denotes	with
T4334	14920-14930	NNS	denotes	pseudopods
T4335	14930-14931	.	denotes	.
T4336	14931-14997	sentence	denotes	The morphological changes are due to cytoskeletal rearrangements.
T4337	14932-14935	DT	denotes	The
T4338	14950-14957	NNS	denotes	changes
T4339	14936-14949	JJ	denotes	morphological
T4340	14958-14961	VBP	denotes	are
T4341	14962-14965	IN	denotes	due
T4342	14966-14968	IN	denotes	to
T4343	14969-14981	JJ	denotes	cytoskeletal
T4344	14982-14996	NNS	denotes	rearrangements
T4345	14996-14997	.	denotes	.
T4346	14997-15119	sentence	denotes	In vitro the activated cells form aggregates recruiting additional cells in the solution thereby reducing its cloudiness.
T4347	14998-15000	FW	denotes	In
T4348	15001-15006	FW	denotes	vitro
T4349	15027-15031	VBP	denotes	form
T4350	15007-15010	DT	denotes	the
T4351	15021-15026	NNS	denotes	cells
T4352	15011-15020	VBN	denotes	activated
T4353	15032-15042	NNS	denotes	aggregates
T4354	15043-15053	VBG	denotes	recruiting
T4355	15054-15064	JJ	denotes	additional
T4356	15065-15070	NNS	denotes	cells
T4357	15071-15073	IN	denotes	in
T4358	15074-15077	DT	denotes	the
T4359	15078-15086	NN	denotes	solution
T4360	15087-15094	RB	denotes	thereby
T4361	15095-15103	VBG	denotes	reducing
T4362	15104-15107	PRP$	denotes	its
T4363	15108-15118	NN	denotes	cloudiness
T4364	15118-15119	.	denotes	.
T4365	15119-15418	sentence	denotes	Analysis of the transmission values of aggregation curves after platelet activation by ristocetin addition (von Willebrand cofactor) showed that both curves differed significantly at the time point of seven seconds after platelet initiation (p = 0.0287, n knock out = 16, n wild type = 15; Fig. 6).
T4366	15120-15128	NN	denotes	Analysis
T4367	15253-15259	VBD	denotes	showed
T4368	15129-15131	IN	denotes	of
T4369	15132-15135	DT	denotes	the
T4370	15149-15155	NNS	denotes	values
T4371	15136-15148	NN	denotes	transmission
T4372	15156-15158	IN	denotes	of
T4373	15159-15170	NN	denotes	aggregation
T4374	15171-15177	NNS	denotes	curves
T4375	15178-15183	IN	denotes	after
T4376	15184-15192	NN	denotes	platelet
T4377	15193-15203	NN	denotes	activation
T4378	15204-15206	IN	denotes	by
T4379	15207-15217	NN	denotes	ristocetin
T4380	15218-15226	NN	denotes	addition
T4381	15227-15228	-LRB-	denotes	(
T4382	15243-15251	NN	denotes	cofactor
T4383	15228-15231	NN	denotes	von
T4384	15232-15242	NN	denotes	Willebrand
T4385	15251-15252	-RRB-	denotes	)
T4386	15260-15264	IN	denotes	that
T4387	15277-15285	VBD	denotes	differed
T4388	15265-15269	DT	denotes	both
T4389	15270-15276	NNS	denotes	curves
T4390	15286-15299	RB	denotes	significantly
T4391	15300-15302	IN	denotes	at
T4392	15303-15306	DT	denotes	the
T4393	15312-15317	NN	denotes	point
T4394	15307-15311	NN	denotes	time
T4395	15318-15320	IN	denotes	of
T4396	15321-15326	CD	denotes	seven
T4397	15327-15334	NNS	denotes	seconds
T4398	15335-15340	IN	denotes	after
T4399	15341-15349	NN	denotes	platelet
T4400	15350-15360	NN	denotes	initiation
T4401	15361-15362	-LRB-	denotes	(
T4402	15410-15414	NN	denotes	Fig.
T4403	15362-15363	NN	denotes	p
T4404	15366-15372	CD	denotes	0.0287
T4405	15364-15365	SYM	denotes	=
T4406	15372-15374	,	denotes	,
T4407	15374-15375	NN	denotes	n
T4408	15382-15385	NN	denotes	out
T4409	15376-15381	NN	denotes	knock
T4410	15388-15390	CD	denotes	16
T4411	15386-15387	SYM	denotes	=
T4412	15390-15392	,	denotes	,
T4413	15392-15393	NN	denotes	n
T4414	15399-15403	NN	denotes	type
T4415	15394-15398	JJ	denotes	wild
T4416	15406-15408	CD	denotes	15
T4417	15404-15405	SYM	denotes	=
T4418	15408-15409	:	denotes	;
T4419	15415-15416	CD	denotes	6
T4420	15416-15417	-RRB-	denotes	)
T4421	15417-15418	.	denotes	.
T4422	15418-15497	sentence	denotes	Annexin A7 deficient platelets showed a slightly lowered aggregation velocity.
T4423	15419-15426	NN	denotes	Annexin
T4424	15427-15429	NN	denotes	A7
T4425	15430-15439	JJ	denotes	deficient
T4426	15440-15449	NNS	denotes	platelets
T4427	15450-15456	VBD	denotes	showed
T4428	15457-15458	DT	denotes	a
T4429	15488-15496	NN	denotes	velocity
T4430	15459-15467	RB	denotes	slightly
T4431	15468-15475	VBN	denotes	lowered
T4432	15476-15487	NN	denotes	aggregation
T4433	15496-15497	.	denotes	.
T4434	15497-15808	sentence	denotes	When we compared the aggregation curves of human platelets from a healthy donor with the ones obtained from an individual with a von Willebrand factor type 1 defect, we found that the difference in the curves was much more pronounced as observed in our studies of healthy mouse platelets and anxA7-/-platelets.
T4435	15498-15502	WRB	denotes	When
T4436	15506-15514	VBD	denotes	compared
T4437	15503-15505	PRP	denotes	we
T4438	15667-15672	VBD	denotes	found
T4439	15515-15518	DT	denotes	the
T4440	15531-15537	NNS	denotes	curves
T4441	15519-15530	NN	denotes	aggregation
T4442	15538-15540	IN	denotes	of
T4443	15541-15546	JJ	denotes	human
T4444	15547-15556	NNS	denotes	platelets
T4445	15557-15561	IN	denotes	from
T4446	15562-15563	DT	denotes	a
T4447	15572-15577	NN	denotes	donor
T4448	15564-15571	JJ	denotes	healthy
T4449	15578-15582	IN	denotes	with
T4450	15583-15586	DT	denotes	the
T4451	15587-15591	NNS	denotes	ones
T4452	15592-15600	VBN	denotes	obtained
T4453	15601-15605	IN	denotes	from
T4454	15606-15608	DT	denotes	an
T4455	15609-15619	NN	denotes	individual
T4456	15620-15624	IN	denotes	with
T4457	15625-15626	DT	denotes	a
T4458	15656-15662	NN	denotes	defect
T4459	15627-15630	NN	denotes	von
T4460	15631-15641	NN	denotes	Willebrand
T4461	15642-15648	NN	denotes	factor
T4462	15649-15653	NN	denotes	type
T4463	15654-15655	CD	denotes	1
T4464	15662-15664	,	denotes	,
T4465	15664-15666	PRP	denotes	we
T4466	15673-15677	IN	denotes	that
T4467	15707-15710	VBD	denotes	was
T4468	15678-15681	DT	denotes	the
T4469	15682-15692	NN	denotes	difference
T4470	15693-15695	IN	denotes	in
T4471	15696-15699	DT	denotes	the
T4472	15700-15706	NNS	denotes	curves
T4473	15711-15715	RB	denotes	much
T4474	15716-15720	RBR	denotes	more
T4475	15721-15731	JJ	denotes	pronounced
T4476	15732-15734	IN	denotes	as
T4477	15735-15743	VBN	denotes	observed
T4478	15744-15746	IN	denotes	in
T4479	15747-15750	PRP$	denotes	our
T4480	15751-15758	NNS	denotes	studies
T4481	15759-15761	IN	denotes	of
T4482	15762-15769	JJ	denotes	healthy
T4483	15776-15785	NNS	denotes	platelets
T4484	15770-15775	NN	denotes	mouse
T4485	15786-15789	CC	denotes	and
T4486	15790-15795	NN	denotes	anxA7
T4487	15798-15807	NNS	denotes	platelets
T4488	15795-15796	SYM	denotes	-
T4489	15796-15797	HYPH	denotes	/
T4490	15797-15798	SYM	denotes	-
T4491	15807-15808	.	denotes	.
T4492	15808-15947	sentence	denotes	Furthermore we found that murine platelets responded immediately to the initiating chemical whereas human platelets have a lag phase [23].
T4493	15809-15820	RB	denotes	Furthermore
T4494	15824-15829	VBD	denotes	found
T4495	15821-15823	PRP	denotes	we
T4496	15830-15834	IN	denotes	that
T4497	15852-15861	VBD	denotes	responded
T4498	15835-15841	JJ	denotes	murine
T4499	15842-15851	NNS	denotes	platelets
T4500	15862-15873	RB	denotes	immediately
T4501	15874-15876	IN	denotes	to
T4502	15877-15880	DT	denotes	the
T4503	15892-15900	NN	denotes	chemical
T4504	15881-15891	VBG	denotes	initiating
T4505	15901-15908	IN	denotes	whereas
T4506	15925-15929	VBP	denotes	have
T4507	15909-15914	JJ	denotes	human
T4508	15915-15924	NNS	denotes	platelets
T4509	15930-15931	DT	denotes	a
T4510	15936-15941	NN	denotes	phase
T4511	15932-15935	NN	denotes	lag
T4512	15942-15943	-LRB-	denotes	[
T4513	15943-15945	CD	denotes	23
T4514	15945-15946	-RRB-	denotes	]
T4515	15946-15947	.	denotes	.
T5213	17042-17049	NN	denotes	Annexin
T5214	17050-17052	NN	denotes	A7
T5215	17056-17063	VBN	denotes	thought
T5216	17053-17055	VBZ	denotes	is
T5217	17064-17066	TO	denotes	to
T5218	17067-17071	VB	denotes	have
T5219	17072-17073	DT	denotes	a
T5220	17074-17078	NN	denotes	role
T5221	17079-17081	IN	denotes	in
T5222	17082-17089	NN	denotes	vesicle
T5223	17090-17096	NN	denotes	fusion
T5224	17097-17100	CC	denotes	and
T5225	17101-17103	IN	denotes	in
T5226	17104-17114	VBG	denotes	regulating
T5227	17115-17118	CC	denotes	and
T5228	17119-17130	VBG	denotes	stabilizing
T5229	17131-17139	NN	denotes	membrane
T5230	17140-17147	NNS	denotes	domains
T5231	17148-17149	-LRB-	denotes	[
T5232	17149-17150	CD	denotes	1
T5233	17150-17151	-RRB-	denotes	]
T5234	17151-17152	.	denotes	.
T5235	17152-17332	sentence	denotes	The protein has been localized to the plasma membrane including raft subdomains, furthermore it is present in the cytosol where it is found on subcellular vesicle-like structures.
T5236	17153-17156	DT	denotes	The
T5237	17157-17164	NN	denotes	protein
T5238	17174-17183	VBN	denotes	localized
T5239	17165-17168	VBZ	denotes	has
T5240	17169-17173	VBN	denotes	been
T5241	17249-17251	VBZ	denotes	is
T5242	17184-17186	IN	denotes	to
T5243	17187-17190	DT	denotes	the
T5244	17198-17206	NN	denotes	membrane
T5245	17191-17197	NN	denotes	plasma
T5246	17207-17216	VBG	denotes	including
T5247	17217-17221	NN	denotes	raft
T5248	17222-17232	NNS	denotes	subdomains
T5249	17232-17234	,	denotes	,
T5250	17234-17245	RB	denotes	furthermore
T5251	17246-17248	PRP	denotes	it
T5252	17252-17259	JJ	denotes	present
T5253	17260-17262	IN	denotes	in
T5254	17263-17266	DT	denotes	the
T5255	17267-17274	NN	denotes	cytosol
T5256	17275-17280	WRB	denotes	where
T5257	17287-17292	VBN	denotes	found
T5258	17281-17283	PRP	denotes	it
T5259	17284-17286	VBZ	denotes	is
T5260	17293-17295	IN	denotes	on
T5261	17296-17307	JJ	denotes	subcellular
T5262	17321-17331	NNS	denotes	structures
T5263	17308-17315	NN	denotes	vesicle
T5264	17316-17320	JJ	denotes	like
T5265	17315-17316	HYPH	denotes	-
T5266	17331-17332	.	denotes	.
T5267	17332-17413	sentence	denotes	This distribution appears to be independent of the tissue or cell type analysed.
T5268	17333-17337	DT	denotes	This
T5269	17338-17350	NN	denotes	distribution
T5270	17351-17358	VBZ	denotes	appears
T5271	17359-17361	TO	denotes	to
T5272	17362-17364	VB	denotes	be
T5273	17365-17376	JJ	denotes	independent
T5274	17377-17379	IN	denotes	of
T5275	17380-17383	DT	denotes	the
T5276	17399-17403	NN	denotes	type
T5277	17384-17390	NN	denotes	tissue
T5278	17391-17393	CC	denotes	or
T5279	17394-17398	NN	denotes	cell
T5280	17404-17412	VBN	denotes	analysed
T5281	17412-17413	.	denotes	.
T5282	17413-17567	sentence	denotes	In specialized or terminally differentiated cells, expression levels increase and frequently the larger of the two isoforms is being expressed [6,34,35].
T5283	17414-17416	IN	denotes	In
T5284	17483-17491	VBP	denotes	increase
T5285	17417-17428	VBN	denotes	specialized
T5286	17458-17463	NNS	denotes	cells
T5287	17429-17431	CC	denotes	or
T5288	17432-17442	RB	denotes	terminally
T5289	17443-17457	VBN	denotes	differentiated
T5290	17463-17465	,	denotes	,
T5291	17465-17475	NN	denotes	expression
T5292	17476-17482	NNS	denotes	levels
T5293	17492-17495	CC	denotes	and
T5294	17496-17506	RB	denotes	frequently
T5295	17547-17556	VBN	denotes	expressed
T5296	17507-17510	DT	denotes	the
T5297	17511-17517	JJR	denotes	larger
T5298	17518-17520	IN	denotes	of
T5299	17521-17524	DT	denotes	the
T5300	17529-17537	NNS	denotes	isoforms
T5301	17525-17528	CD	denotes	two
T5302	17538-17540	VBZ	denotes	is
T5303	17541-17546	VBG	denotes	being
T5304	17557-17558	-LRB-	denotes	[
T5305	17563-17565	CD	denotes	35
T5306	17558-17559	CD	denotes	6
T5307	17559-17560	,	denotes	,
T5308	17560-17562	CD	denotes	34
T5309	17562-17563	,	denotes	,
T5310	17565-17566	-RRB-	denotes	]
T5311	17566-17567	.	denotes	.
T5312	17567-17726	sentence	denotes	Red blood cells, which were thought to be devoid of annexin A7, were recently shown to harbor the 47 kDa isoform together with its binding partner sorcin [7].
T5313	17568-17571	JJ	denotes	Red
T5314	17578-17583	NNS	denotes	cells
T5315	17572-17577	NN	denotes	blood
T5316	17646-17651	VBN	denotes	shown
T5317	17583-17585	,	denotes	,
T5318	17585-17590	WDT	denotes	which
T5319	17596-17603	VBN	denotes	thought
T5320	17591-17595	VBD	denotes	were
T5321	17604-17606	TO	denotes	to
T5322	17607-17609	VB	denotes	be
T5323	17610-17616	JJ	denotes	devoid
T5324	17617-17619	IN	denotes	of
T5325	17620-17627	NN	denotes	annexin
T5326	17628-17630	NN	denotes	A7
T5327	17630-17632	,	denotes	,
T5328	17632-17636	VBD	denotes	were
T5329	17637-17645	RB	denotes	recently
T5330	17652-17654	TO	denotes	to
T5331	17655-17661	VB	denotes	harbor
T5332	17662-17665	DT	denotes	the
T5333	17673-17680	NN	denotes	isoform
T5334	17666-17668	CD	denotes	47
T5335	17669-17672	NN	denotes	kDa
T5336	17681-17689	RB	denotes	together
T5337	17690-17694	IN	denotes	with
T5338	17695-17698	PRP$	denotes	its
T5339	17707-17714	NN	denotes	partner
T5340	17699-17706	VBG	denotes	binding
T5341	17715-17721	NN	denotes	sorcin
T5342	17722-17723	-LRB-	denotes	[
T5343	17723-17724	CD	denotes	7
T5344	17724-17725	-RRB-	denotes	]
T5345	17725-17726	.	denotes	.
T5346	17726-17850	sentence	denotes	We showed the presence of the 51 kDa isoform as well, adding red blood cells to the list of cells that harbor this isoform.
T5347	17727-17729	PRP	denotes	We
T5348	17730-17736	VBD	denotes	showed
T5349	17737-17740	DT	denotes	the
T5350	17741-17749	NN	denotes	presence
T5351	17750-17752	IN	denotes	of
T5352	17753-17756	DT	denotes	the
T5353	17764-17771	NN	denotes	isoform
T5354	17757-17759	CD	denotes	51
T5355	17760-17763	NN	denotes	kDa
T5356	17772-17774	RB	denotes	as
T5357	17775-17779	RB	denotes	well
T5358	17779-17781	,	denotes	,
T5359	17781-17787	VBG	denotes	adding
T5360	17788-17791	JJ	denotes	red
T5361	17798-17803	NNS	denotes	cells
T5362	17792-17797	NN	denotes	blood
T5363	17804-17806	IN	denotes	to
T5364	17807-17810	DT	denotes	the
T5365	17811-17815	NN	denotes	list
T5366	17816-17818	IN	denotes	of
T5367	17819-17824	NNS	denotes	cells
T5368	17825-17829	WDT	denotes	that
T5369	17830-17836	VBP	denotes	harbor
T5370	17837-17841	DT	denotes	this
T5371	17842-17849	NN	denotes	isoform
T5372	17849-17850	.	denotes	.
T5373	17850-18074	sentence	denotes	Salzer et al. [7] not only demonstrated the presence of annexin A7 in red blood cells, they also showed that annexin A7 and sorcin were enriched in membrane raft domains of nanovesicles formed from red blood cells in vitro.
T5374	17851-17857	NNP	denotes	Salzer
T5375	17948-17954	VBD	denotes	showed
T5376	17858-17860	FW	denotes	et
T5377	17861-17864	FW	denotes	al.
T5378	17865-17866	-LRB-	denotes	[
T5379	17866-17867	CD	denotes	7
T5380	17867-17868	-RRB-	denotes	]
T5381	17869-17872	RB	denotes	not
T5382	17873-17877	RB	denotes	only
T5383	17878-17890	VBD	denotes	demonstrated
T5384	17891-17894	DT	denotes	the
T5385	17895-17903	NN	denotes	presence
T5386	17904-17906	IN	denotes	of
T5387	17907-17914	NN	denotes	annexin
T5388	17915-17917	NN	denotes	A7
T5389	17918-17920	IN	denotes	in
T5390	17921-17924	JJ	denotes	red
T5391	17931-17936	NNS	denotes	cells
T5392	17925-17930	NN	denotes	blood
T5393	17936-17938	,	denotes	,
T5394	17938-17942	PRP	denotes	they
T5395	17943-17947	RB	denotes	also
T5396	17955-17959	IN	denotes	that
T5397	17982-17986	VBD	denotes	were
T5398	17960-17967	NN	denotes	annexin
T5399	17968-17970	NN	denotes	A7
T5400	17971-17974	CC	denotes	and
T5401	17975-17981	NN	denotes	sorcin
T5402	17987-17995	JJ	denotes	enriched
T5403	17996-17998	IN	denotes	in
T5404	17999-18007	NN	denotes	membrane
T5405	18008-18012	NN	denotes	raft
T5406	18013-18020	NNS	denotes	domains
T5407	18021-18023	IN	denotes	of
T5408	18024-18036	NNS	denotes	nanovesicles
T5409	18037-18043	VBN	denotes	formed
T5410	18044-18048	IN	denotes	from
T5411	18049-18052	JJ	denotes	red
T5412	18059-18064	NNS	denotes	cells
T5413	18053-18058	NN	denotes	blood
T5414	18065-18067	FW	denotes	in
T5415	18068-18073	FW	denotes	vitro
T5416	18073-18074	.	denotes	.
T5417	18074-18193	sentence	denotes	Raft domains in general are considered key players in membrane organization and in mediating the vesiculation process.
T5418	18075-18079	NN	denotes	Raft
T5419	18080-18087	NNS	denotes	domains
T5420	18103-18113	VBN	denotes	considered
T5421	18088-18090	IN	denotes	in
T5422	18091-18098	JJ	denotes	general
T5423	18099-18102	VBP	denotes	are
T5424	18114-18117	JJ	denotes	key
T5425	18118-18125	NNS	denotes	players
T5426	18126-18128	IN	denotes	in
T5427	18129-18137	NN	denotes	membrane
T5428	18138-18150	NN	denotes	organization
T5429	18151-18154	CC	denotes	and
T5430	18155-18157	IN	denotes	in
T5431	18158-18167	VBG	denotes	mediating
T5432	18168-18171	DT	denotes	the
T5433	18185-18192	NN	denotes	process
T5434	18172-18184	NN	denotes	vesiculation
T5435	18192-18193	.	denotes	.
T5436	18193-18397	sentence	denotes	They result from the clustering of sphingolipids and cholesterol in the outer leaflet of the membrane connected to phospholipids and cholesterol in the inner leaflet and are enriched in special proteins.
T5437	18194-18198	PRP	denotes	They
T5438	18199-18205	VBP	denotes	result
T5439	18206-18210	IN	denotes	from
T5440	18211-18214	DT	denotes	the
T5441	18215-18225	NN	denotes	clustering
T5442	18226-18228	IN	denotes	of
T5443	18229-18242	NNS	denotes	sphingolipids
T5444	18243-18246	CC	denotes	and
T5445	18247-18258	NN	denotes	cholesterol
T5446	18259-18261	IN	denotes	in
T5447	18262-18265	DT	denotes	the
T5448	18272-18279	NN	denotes	leaflet
T5449	18266-18271	JJ	denotes	outer
T5450	18280-18282	IN	denotes	of
T5451	18283-18286	DT	denotes	the
T5452	18287-18295	NN	denotes	membrane
T5453	18296-18305	VBN	denotes	connected
T5454	18306-18308	IN	denotes	to
T5455	18309-18322	NNS	denotes	phospholipids
T5456	18323-18326	CC	denotes	and
T5457	18327-18338	NN	denotes	cholesterol
T5458	18339-18341	IN	denotes	in
T5459	18342-18345	DT	denotes	the
T5460	18352-18359	NN	denotes	leaflet
T5461	18346-18351	JJ	denotes	inner
T5462	18360-18363	CC	denotes	and
T5463	18364-18367	VBP	denotes	are
T5464	18368-18376	JJ	denotes	enriched
T5465	18377-18379	IN	denotes	in
T5466	18380-18387	JJ	denotes	special
T5467	18388-18396	NN	denotes	proteins
T5468	18396-18397	.	denotes	.
T5469	18397-18573	sentence	denotes	Biochemically rafts are defined as membranes that are resistant to extraction by cold Triton X-100 and can be floated to low densities in sucrose gradient centrifugation [36].
T5470	18398-18411	RB	denotes	Biochemically
T5471	18422-18429	VBN	denotes	defined
T5472	18412-18417	NNS	denotes	rafts
T5473	18418-18421	VBP	denotes	are
T5474	18430-18432	IN	denotes	as
T5475	18433-18442	NNS	denotes	membranes
T5476	18443-18447	WDT	denotes	that
T5477	18448-18451	VBP	denotes	are
T5478	18452-18461	JJ	denotes	resistant
T5479	18462-18464	IN	denotes	to
T5480	18465-18475	NN	denotes	extraction
T5481	18476-18478	IN	denotes	by
T5482	18479-18483	JJ	denotes	cold
T5483	18491-18492	NN	denotes	X
T5484	18484-18490	NN	denotes	Triton
T5485	18492-18493	HYPH	denotes	-
T5486	18493-18496	CD	denotes	100
T5487	18497-18500	CC	denotes	and
T5488	18501-18504	MD	denotes	can
T5489	18508-18515	VBN	denotes	floated
T5490	18505-18507	VB	denotes	be
T5491	18516-18518	IN	denotes	to
T5492	18519-18522	JJ	denotes	low
T5493	18523-18532	NNS	denotes	densities
T5494	18533-18535	IN	denotes	in
T5495	18536-18543	NN	denotes	sucrose
T5496	18544-18552	NN	denotes	gradient
T5497	18553-18567	NN	denotes	centrifugation
T5498	18568-18569	-LRB-	denotes	[
T5499	18569-18571	CD	denotes	36
T5500	18571-18572	-RRB-	denotes	]
T5501	18572-18573	.	denotes	.
T5502	18573-18732	sentence	denotes	The findings of Caohuy et al. [37] that annexin A7 mediates membrane aggregation also suggested that annexin A7 is an essential component during vesiculation.
T5503	18574-18577	DT	denotes	The
T5504	18578-18586	NNS	denotes	findings
T5505	18660-18669	VBD	denotes	suggested
T5506	18587-18589	IN	denotes	of
T5507	18590-18596	NNP	denotes	Caohuy
T5508	18597-18599	FW	denotes	et
T5509	18600-18603	FW	denotes	al.
T5510	18604-18605	-LRB-	denotes	[
T5511	18605-18607	CD	denotes	37
T5512	18607-18608	-RRB-	denotes	]
T5513	18609-18613	IN	denotes	that
T5514	18625-18633	VBZ	denotes	mediates
T5515	18614-18621	NN	denotes	annexin
T5516	18622-18624	NN	denotes	A7
T5517	18634-18642	NN	denotes	membrane
T5518	18643-18654	NN	denotes	aggregation
T5519	18655-18659	RB	denotes	also
T5520	18670-18674	IN	denotes	that
T5521	18686-18688	VBZ	denotes	is
T5522	18675-18682	NN	denotes	annexin
T5523	18683-18685	NN	denotes	A7
T5524	18689-18691	DT	denotes	an
T5525	18702-18711	NN	denotes	component
T5526	18692-18701	JJ	denotes	essential
T5527	18712-18718	IN	denotes	during
T5528	18719-18731	NN	denotes	vesiculation
T5529	18731-18732	.	denotes	.
T5530	18732-18861	sentence	denotes	In addition they reported a further activation of the vesiculation process by GTP and proposed that annexin A7 acts as a GTPase.
T5531	18733-18735	IN	denotes	In
T5532	18750-18758	VBD	denotes	reported
T5533	18736-18744	NN	denotes	addition
T5534	18745-18749	PRP	denotes	they
T5535	18759-18760	DT	denotes	a
T5536	18769-18779	NN	denotes	activation
T5537	18761-18768	JJ	denotes	further
T5538	18780-18782	IN	denotes	of
T5539	18783-18786	DT	denotes	the
T5540	18800-18807	NN	denotes	process
T5541	18787-18799	NN	denotes	vesiculation
T5542	18808-18810	IN	denotes	by
T5543	18811-18814	NN	denotes	GTP
T5544	18815-18818	CC	denotes	and
T5545	18819-18827	VBD	denotes	proposed
T5546	18828-18832	IN	denotes	that
T5547	18844-18848	VBZ	denotes	acts
T5548	18833-18840	NN	denotes	annexin
T5549	18841-18843	NN	denotes	A7
T5550	18849-18851	IN	denotes	as
T5551	18852-18853	DT	denotes	a
T5552	18854-18860	NN	denotes	GTPase
T5553	18860-18861	.	denotes	.
T5554	18861-18944	sentence	denotes	Similarly, the presence of GTP enhanced the secretion of surfactant by annexin A7.
T5555	18862-18871	RB	denotes	Similarly
T5556	18893-18901	VBD	denotes	enhanced
T5557	18871-18873	,	denotes	,
T5558	18873-18876	DT	denotes	the
T5559	18877-18885	NN	denotes	presence
T5560	18886-18888	IN	denotes	of
T5561	18889-18892	NN	denotes	GTP
T5562	18902-18905	DT	denotes	the
T5563	18906-18915	NN	denotes	secretion
T5564	18916-18918	IN	denotes	of
T5565	18919-18929	NN	denotes	surfactant
T5566	18930-18932	IN	denotes	by
T5567	18933-18940	NN	denotes	annexin
T5568	18941-18943	NN	denotes	A7
T5569	18943-18944	.	denotes	.
T5570	18944-19151	sentence	denotes	These results were thought to support a direct role for annexin A7 in surfactant secretion, but in these studies annexin A7 mediated membrane fusion was separated from a second GTP-dependent mechanism [38].
T5571	18945-18950	DT	denotes	These
T5572	18951-18958	NNS	denotes	results
T5573	18964-18971	VBN	denotes	thought
T5574	18959-18963	VBD	denotes	were
T5575	18972-18974	TO	denotes	to
T5576	18975-18982	VB	denotes	support
T5577	18983-18984	DT	denotes	a
T5578	18992-18996	NN	denotes	role
T5579	18985-18991	JJ	denotes	direct
T5580	18997-19000	IN	denotes	for
T5581	19001-19008	NN	denotes	annexin
T5582	19009-19011	NN	denotes	A7
T5583	19012-19014	IN	denotes	in
T5584	19015-19025	JJ	denotes	surfactant
T5585	19026-19035	NN	denotes	secretion
T5586	19035-19037	,	denotes	,
T5587	19037-19040	CC	denotes	but
T5588	19041-19043	IN	denotes	in
T5589	19098-19107	VBN	denotes	separated
T5590	19044-19049	DT	denotes	these
T5591	19050-19057	NNS	denotes	studies
T5592	19058-19065	NN	denotes	annexin
T5593	19066-19068	NN	denotes	A7
T5594	19069-19077	VBN	denotes	mediated
T5595	19087-19093	NN	denotes	fusion
T5596	19078-19086	NN	denotes	membrane
T5597	19094-19097	VBD	denotes	was
T5598	19108-19112	IN	denotes	from
T5599	19113-19114	DT	denotes	a
T5600	19136-19145	NN	denotes	mechanism
T5601	19115-19121	JJ	denotes	second
T5602	19122-19125	NN	denotes	GTP
T5603	19126-19135	JJ	denotes	dependent
T5604	19125-19126	HYPH	denotes	-
T5605	19146-19147	-LRB-	denotes	[
T5606	19147-19149	CD	denotes	38
T5607	19149-19150	-RRB-	denotes	]
T5608	19150-19151	.	denotes	.
T5609	19151-19266	sentence	denotes	Having an annexin A7 knockout mouse we tested the involvement of annexin A7 in budding of red blood cell vesicles.
T5610	19152-19158	VBG	denotes	Having
T5611	19191-19197	VBD	denotes	tested
T5612	19159-19161	DT	denotes	an
T5613	19182-19187	NN	denotes	mouse
T5614	19162-19169	NN	denotes	annexin
T5615	19170-19172	NN	denotes	A7
T5616	19173-19181	NN	denotes	knockout
T5617	19188-19190	PRP	denotes	we
T5618	19198-19201	DT	denotes	the
T5619	19202-19213	NN	denotes	involvement
T5620	19214-19216	IN	denotes	of
T5621	19217-19224	NN	denotes	annexin
T5622	19225-19227	NN	denotes	A7
T5623	19228-19230	IN	denotes	in
T5624	19231-19238	NN	denotes	budding
T5625	19239-19241	IN	denotes	of
T5626	19242-19245	JJ	denotes	red
T5627	19252-19256	NN	denotes	cell
T5628	19246-19251	NN	denotes	blood
T5629	19257-19265	NNS	denotes	vesicles
T5630	19265-19266	.	denotes	.
T5631	19266-19411	sentence	denotes	Our data suggest that the efficiency of micro- and nanovesicle formation is not significantly different in wild type and mutant red blood cells.
T5632	19267-19270	PRP$	denotes	Our
T5633	19271-19275	NNS	denotes	data
T5634	19276-19283	VBP	denotes	suggest
T5635	19284-19288	IN	denotes	that
T5636	19340-19342	VBZ	denotes	is
T5637	19289-19292	DT	denotes	the
T5638	19293-19303	NN	denotes	efficiency
T5639	19304-19306	IN	denotes	of
T5640	19307-19312	AFX	denotes	micro
T5641	19318-19329	NN	denotes	nanovesicle
T5642	19312-19313	HYPH	denotes	-
T5643	19314-19317	CC	denotes	and
T5644	19330-19339	NN	denotes	formation
T5645	19343-19346	RB	denotes	not
T5646	19347-19360	RB	denotes	significantly
T5647	19361-19370	JJ	denotes	different
T5648	19371-19373	IN	denotes	in
T5649	19374-19378	JJ	denotes	wild
T5650	19379-19383	NN	denotes	type
T5651	19405-19410	NNS	denotes	cells
T5652	19384-19387	CC	denotes	and
T5653	19388-19394	JJ	denotes	mutant
T5654	19395-19398	JJ	denotes	red
T5655	19399-19404	NN	denotes	blood
T5656	19410-19411	.	denotes	.
T5657	19411-19590	sentence	denotes	Likewise, Dictyostelium discoideum cells, in which the single annexin gene was inactivated, were not impaired in processes requiring membrane fusion [[39]; and data unpublished].
T5658	19412-19420	RB	denotes	Likewise
T5659	19504-19508	VBD	denotes	were
T5660	19420-19422	,	denotes	,
T5661	19422-19435	NNP	denotes	Dictyostelium
T5662	19436-19446	NNP	denotes	discoideum
T5663	19447-19452	NNS	denotes	cells
T5664	19452-19454	,	denotes	,
T5665	19454-19456	IN	denotes	in
T5666	19487-19490	VBD	denotes	was
T5667	19457-19462	WDT	denotes	which
T5668	19463-19466	DT	denotes	the
T5669	19482-19486	NN	denotes	gene
T5670	19467-19473	JJ	denotes	single
T5671	19474-19481	NN	denotes	annexin
T5672	19491-19502	JJ	denotes	inactivated
T5673	19502-19504	,	denotes	,
T5674	19509-19512	RB	denotes	not
T5675	19513-19521	JJ	denotes	impaired
T5676	19522-19524	IN	denotes	in
T5677	19525-19534	NNS	denotes	processes
T5678	19535-19544	VBG	denotes	requiring
T5679	19545-19553	NN	denotes	membrane
T5680	19554-19560	NN	denotes	fusion
T5681	19561-19562	-LRB-	denotes	[
T5682	19563-19565	CD	denotes	39
T5683	19562-19563	-LRB-	denotes	[
T5684	19565-19566	-RRB-	denotes	]
T5685	19566-19567	:	denotes	;
T5686	19568-19571	CC	denotes	and
T5687	19572-19576	NNS	denotes	data
T5688	19577-19588	JJ	denotes	unpublished
T5689	19588-19589	-RRB-	denotes	]
T5690	19589-19590	.	denotes	.
T5691	19590-19752	sentence	denotes	It might well be that the observed fusion of phospholipid layers by annexin A7 in the presence of high Ca2+ concentrations may turn out to be an in vitro effect.
T5692	19591-19593	PRP	denotes	It
T5693	19605-19607	VB	denotes	be
T5694	19594-19599	MD	denotes	might
T5695	19600-19604	RB	denotes	well
T5696	19608-19612	IN	denotes	that
T5697	19718-19722	VB	denotes	turn
T5698	19613-19616	DT	denotes	the
T5699	19626-19632	NN	denotes	fusion
T5700	19617-19625	VBN	denotes	observed
T5701	19633-19635	IN	denotes	of
T5702	19636-19648	NN	denotes	phospholipid
T5703	19649-19655	NNS	denotes	layers
T5704	19656-19658	IN	denotes	by
T5705	19659-19666	NN	denotes	annexin
T5706	19667-19669	NN	denotes	A7
T5707	19670-19672	IN	denotes	in
T5708	19673-19676	DT	denotes	the
T5709	19677-19685	NN	denotes	presence
T5710	19686-19688	IN	denotes	of
T5711	19689-19693	JJ	denotes	high
T5712	19699-19713	NNS	denotes	concentrations
T5713	19694-19698	NN	denotes	Ca2+
T5714	19714-19717	MD	denotes	may
T5715	19723-19726	RP	denotes	out
T5716	19727-19729	TO	denotes	to
T5717	19730-19732	VB	denotes	be
T5718	19733-19735	DT	denotes	an
T5719	19745-19751	NN	denotes	effect
T5720	19736-19738	FW	denotes	in
T5721	19739-19744	FW	denotes	vitro
T5722	19751-19752	.	denotes	.
T5723	19752-20019	sentence	denotes	Similarly, the high abundance of annexin A7 in micro- and nanovesicles might be fortuitous as a significant percentage of the red blood cell membrane, with which annexin A7 associates when the Ca2+ levels rise, appears to be involved in the formation of exovesicles.
T5724	19753-19762	RB	denotes	Similarly
T5725	19830-19832	VB	denotes	be
T5726	19762-19764	,	denotes	,
T5727	19764-19767	DT	denotes	the
T5728	19773-19782	NN	denotes	abundance
T5729	19768-19772	JJ	denotes	high
T5730	19783-19785	IN	denotes	of
T5731	19786-19793	NN	denotes	annexin
T5732	19794-19796	NN	denotes	A7
T5733	19797-19799	IN	denotes	in
T5734	19800-19805	AFX	denotes	micro
T5735	19811-19823	NNS	denotes	nanovesicles
T5736	19805-19806	HYPH	denotes	-
T5737	19807-19810	CC	denotes	and
T5738	19824-19829	MD	denotes	might
T5739	19833-19843	JJ	denotes	fortuitous
T5740	19844-19846	IN	denotes	as
T5741	19964-19971	VBZ	denotes	appears
T5742	19847-19848	DT	denotes	a
T5743	19861-19871	NN	denotes	percentage
T5744	19849-19860	JJ	denotes	significant
T5745	19872-19874	IN	denotes	of
T5746	19875-19878	DT	denotes	the
T5747	19894-19902	NN	denotes	membrane
T5748	19879-19882	JJ	denotes	red
T5749	19889-19893	NN	denotes	cell
T5750	19883-19888	NN	denotes	blood
T5751	19902-19904	,	denotes	,
T5752	19904-19908	IN	denotes	with
T5753	19926-19936	VBZ	denotes	associates
T5754	19909-19914	WDT	denotes	which
T5755	19915-19922	NN	denotes	annexin
T5756	19923-19925	NN	denotes	A7
T5757	19937-19941	WRB	denotes	when
T5758	19958-19962	VBP	denotes	rise
T5759	19942-19945	DT	denotes	the
T5760	19951-19957	NNS	denotes	levels
T5761	19946-19950	NN	denotes	Ca2+
T5762	19962-19964	,	denotes	,
T5763	19972-19974	TO	denotes	to
T5764	19978-19986	VBN	denotes	involved
T5765	19975-19977	VB	denotes	be
T5766	19987-19989	IN	denotes	in
T5767	19990-19993	DT	denotes	the
T5768	19994-20003	NN	denotes	formation
T5769	20004-20006	IN	denotes	of
T5770	20007-20018	NNS	denotes	exovesicles
T5771	20018-20019	.	denotes	.
T5772	20019-20204	sentence	denotes	Furthermore, the distribution of both annexin A7 isoforms in gradients of red blood cells indicates a function which differs from organizing subcellular membranes or membrane pathways.
T5773	20020-20031	RB	denotes	Furthermore
T5774	20110-20119	VBZ	denotes	indicates
T5775	20031-20033	,	denotes	,
T5776	20033-20036	DT	denotes	the
T5777	20037-20049	NN	denotes	distribution
T5778	20050-20052	IN	denotes	of
T5779	20053-20057	DT	denotes	both
T5780	20069-20077	NNS	denotes	isoforms
T5781	20058-20065	NN	denotes	annexin
T5782	20066-20068	NN	denotes	A7
T5783	20078-20080	IN	denotes	in
T5784	20081-20090	NNS	denotes	gradients
T5785	20091-20093	IN	denotes	of
T5786	20094-20097	JJ	denotes	red
T5787	20104-20109	NNS	denotes	cells
T5788	20098-20103	NN	denotes	blood
T5789	20120-20121	DT	denotes	a
T5790	20122-20130	NN	denotes	function
T5791	20131-20136	WDT	denotes	which
T5792	20137-20144	VBZ	denotes	differs
T5793	20145-20149	IN	denotes	from
T5794	20150-20160	VBG	denotes	organizing
T5795	20161-20172	JJ	denotes	subcellular
T5796	20173-20182	NNS	denotes	membranes
T5797	20183-20185	CC	denotes	or
T5798	20186-20194	NN	denotes	membrane
T5799	20195-20203	NNS	denotes	pathways
T5800	20203-20204	.	denotes	.
T5801	20204-20420	sentence	denotes	Whereas annexin A2 is tightly associated with endosomes and may have functions in membrane fusion and the endosomal pathway, annexin A7 distributes with plasma membrane raft domains of different types and densities.
T5802	20205-20212	IN	denotes	Whereas
T5803	20235-20245	VBN	denotes	associated
T5804	20213-20220	NN	denotes	annexin
T5805	20221-20223	NN	denotes	A2
T5806	20224-20226	VBZ	denotes	is
T5807	20227-20234	RB	denotes	tightly
T5808	20341-20352	VBZ	denotes	distributes
T5809	20246-20250	IN	denotes	with
T5810	20251-20260	NNS	denotes	endosomes
T5811	20261-20264	CC	denotes	and
T5812	20265-20268	MD	denotes	may
T5813	20269-20273	VB	denotes	have
T5814	20274-20283	NNS	denotes	functions
T5815	20284-20286	IN	denotes	in
T5816	20287-20295	NN	denotes	membrane
T5817	20296-20302	NN	denotes	fusion
T5818	20303-20306	CC	denotes	and
T5819	20307-20310	DT	denotes	the
T5820	20321-20328	NN	denotes	pathway
T5821	20311-20320	JJ	denotes	endosomal
T5822	20328-20330	,	denotes	,
T5823	20330-20337	NN	denotes	annexin
T5824	20338-20340	NN	denotes	A7
T5825	20353-20357	IN	denotes	with
T5826	20358-20364	NN	denotes	plasma
T5827	20365-20373	NN	denotes	membrane
T5828	20379-20386	NNS	denotes	domains
T5829	20374-20378	NN	denotes	raft
T5830	20387-20389	IN	denotes	of
T5831	20390-20399	JJ	denotes	different
T5832	20400-20405	NNS	denotes	types
T5833	20406-20409	CC	denotes	and
T5834	20410-20419	NNS	denotes	densities
T5835	20419-20420	.	denotes	.
T5836	20420-20654	sentence	denotes	Interestingly, in vesicles of red blood cells lacking annexin A7 the amount of sorcin is lowered, indicating that its localisation is affected by the loss of annexin A7 or its expression during red blood cell development was reduced.
T5837	20421-20434	RB	denotes	Interestingly
T5838	20510-20517	VBN	denotes	lowered
T5839	20434-20436	,	denotes	,
T5840	20436-20438	IN	denotes	in
T5841	20439-20447	NNS	denotes	vesicles
T5842	20448-20450	IN	denotes	of
T5843	20451-20454	JJ	denotes	red
T5844	20461-20466	NNS	denotes	cells
T5845	20455-20460	NN	denotes	blood
T5846	20467-20474	VBG	denotes	lacking
T5847	20475-20482	NN	denotes	annexin
T5848	20483-20485	NN	denotes	A7
T5849	20486-20489	DT	denotes	the
T5850	20490-20496	NN	denotes	amount
T5851	20497-20499	IN	denotes	of
T5852	20500-20506	NN	denotes	sorcin
T5853	20507-20509	VBZ	denotes	is
T5854	20517-20519	,	denotes	,
T5855	20519-20529	VBG	denotes	indicating
T5856	20530-20534	IN	denotes	that
T5857	20555-20563	VBN	denotes	affected
T5858	20535-20538	PRP$	denotes	its
T5859	20539-20551	NN	denotes	localisation
T5860	20552-20554	VBZ	denotes	is
T5861	20564-20566	IN	denotes	by
T5862	20567-20570	DT	denotes	the
T5863	20571-20575	NN	denotes	loss
T5864	20576-20578	IN	denotes	of
T5865	20579-20586	NN	denotes	annexin
T5866	20587-20589	NN	denotes	A7
T5867	20590-20592	CC	denotes	or
T5868	20593-20596	PRP$	denotes	its
T5869	20597-20607	NN	denotes	expression
T5870	20646-20653	VBN	denotes	reduced
T5871	20608-20614	IN	denotes	during
T5872	20615-20618	JJ	denotes	red
T5873	20625-20629	NN	denotes	cell
T5874	20619-20624	NN	denotes	blood
T5875	20630-20641	NN	denotes	development
T5876	20642-20645	VBD	denotes	was
T5877	20653-20654	.	denotes	.
T5878	20654-20793	sentence	denotes	Having excluded a direct role in vesicle formation and membrane fusion, annexin A7 might act by its property as Ca2+-binding protein [17].
T5879	20655-20661	VBG	denotes	Having
T5880	20662-20670	VBN	denotes	excluded
T5881	20744-20747	VB	denotes	act
T5882	20671-20672	DT	denotes	a
T5883	20680-20684	NN	denotes	role
T5884	20673-20679	JJ	denotes	direct
T5885	20685-20687	IN	denotes	in
T5886	20688-20695	NN	denotes	vesicle
T5887	20696-20705	NN	denotes	formation
T5888	20706-20709	CC	denotes	and
T5889	20710-20718	NN	denotes	membrane
T5890	20719-20725	NN	denotes	fusion
T5891	20725-20727	,	denotes	,
T5892	20727-20734	NN	denotes	annexin
T5893	20735-20737	NN	denotes	A7
T5894	20738-20743	MD	denotes	might
T5895	20748-20750	IN	denotes	by
T5896	20751-20754	PRP$	denotes	its
T5897	20755-20763	NN	denotes	property
T5898	20764-20766	IN	denotes	as
T5899	20767-20771	NN	denotes	Ca2+
T5900	20772-20779	VBG	denotes	binding
T5901	20771-20772	HYPH	denotes	-
T5902	20780-20787	NN	denotes	protein
T5903	20788-20789	-LRB-	denotes	[
T5904	20789-20791	CD	denotes	17
T5905	20791-20792	-RRB-	denotes	]
T5906	20792-20793	.	denotes	.
T5907	20793-21031	sentence	denotes	Previous results in which annexin A7 was shown to play a role in membrane aggregation might be explained by a supportive function of annexin A7 in that it interferes with the local Ca2+ homeostasis thus influencing membrane organization.
T5908	20794-20802	JJ	denotes	Previous
T5909	20803-20810	NNS	denotes	results
T5910	20889-20898	VBN	denotes	explained
T5911	20811-20813	IN	denotes	in
T5912	20835-20840	VBN	denotes	shown
T5913	20814-20819	WDT	denotes	which
T5914	20820-20827	NN	denotes	annexin
T5915	20828-20830	NN	denotes	A7
T5916	20831-20834	VBD	denotes	was
T5917	20841-20843	TO	denotes	to
T5918	20844-20848	VB	denotes	play
T5919	20849-20850	DT	denotes	a
T5920	20851-20855	NN	denotes	role
T5921	20856-20858	IN	denotes	in
T5922	20859-20867	NN	denotes	membrane
T5923	20868-20879	NN	denotes	aggregation
T5924	20880-20885	MD	denotes	might
T5925	20886-20888	VB	denotes	be
T5926	20899-20901	IN	denotes	by
T5927	20902-20903	DT	denotes	a
T5928	20915-20923	NN	denotes	function
T5929	20904-20914	JJ	denotes	supportive
T5930	20924-20926	IN	denotes	of
T5931	20927-20934	NN	denotes	annexin
T5932	20935-20937	NN	denotes	A7
T5933	20938-20940	IN	denotes	in
T5934	20949-20959	VBZ	denotes	interferes
T5935	20941-20945	IN	denotes	that
T5936	20946-20948	PRP	denotes	it
T5937	20960-20964	IN	denotes	with
T5938	20965-20968	DT	denotes	the
T5939	20980-20991	NN	denotes	homeostasis
T5940	20969-20974	JJ	denotes	local
T5941	20975-20979	NN	denotes	Ca2+
T5942	20992-20996	RB	denotes	thus
T5943	20997-21008	VBG	denotes	influencing
T5944	21009-21017	NN	denotes	membrane
T5945	21018-21030	NN	denotes	organization
T5946	21030-21031	.	denotes	.
T5947	21031-21169	sentence	denotes	As the annexins belong to a wide spread and evolutionarily conserved protein family, redundant, but not identical functions are expected.
T5948	21032-21034	IN	denotes	As
T5949	21048-21054	VBP	denotes	belong
T5950	21035-21038	DT	denotes	the
T5951	21039-21047	NNS	denotes	annexins
T5952	21160-21168	VBN	denotes	expected
T5953	21055-21057	IN	denotes	to
T5954	21058-21059	DT	denotes	a
T5955	21109-21115	NN	denotes	family
T5956	21060-21064	RB	denotes	wide
T5957	21065-21071	VBN	denotes	spread
T5958	21072-21075	CC	denotes	and
T5959	21076-21090	RB	denotes	evolutionarily
T5960	21091-21100	VBN	denotes	conserved
T5961	21101-21108	NN	denotes	protein
T5962	21115-21117	,	denotes	,
T5963	21117-21126	NN	denotes	redundant
T5964	21136-21145	JJ	denotes	identical
T5965	21126-21128	,	denotes	,
T5966	21128-21131	CC	denotes	but
T5967	21132-21135	RB	denotes	not
T5968	21146-21155	NNS	denotes	functions
T5969	21156-21159	VBP	denotes	are
T5970	21168-21169	.	denotes	.
T5971	21169-21302	sentence	denotes	However, so far no other members of the annexin family, which may substitute for annexin A7, have been described in red blood cells.
T5972	21170-21177	RB	denotes	However
T5973	21273-21282	VBN	denotes	described
T5974	21177-21179	,	denotes	,
T5975	21179-21181	RB	denotes	so
T5976	21182-21185	RB	denotes	far
T5977	21186-21188	DT	denotes	no
T5978	21195-21202	NNS	denotes	members
T5979	21189-21194	JJ	denotes	other
T5980	21203-21205	IN	denotes	of
T5981	21206-21209	DT	denotes	the
T5982	21218-21224	NN	denotes	family
T5983	21210-21217	NN	denotes	annexin
T5984	21224-21226	,	denotes	,
T5985	21226-21231	WDT	denotes	which
T5986	21236-21246	VB	denotes	substitute
T5987	21232-21235	MD	denotes	may
T5988	21247-21250	IN	denotes	for
T5989	21251-21258	NN	denotes	annexin
T5990	21259-21261	NN	denotes	A7
T5991	21261-21263	,	denotes	,
T5992	21263-21267	VBP	denotes	have
T5993	21268-21272	VBN	denotes	been
T5994	21283-21285	IN	denotes	in
T5995	21286-21289	JJ	denotes	red
T5996	21296-21301	NNS	denotes	cells
T5997	21290-21295	NN	denotes	blood
T5998	21301-21302	.	denotes	.
T5999	21302-21494	sentence	denotes	The structural basis for the elasticy of red blood cells in circulation are long range molecular functions of the plasma membrane and the membrane associated part of the cytoskeleton [40-43].
T6000	21303-21306	DT	denotes	The
T6001	21318-21323	NN	denotes	basis
T6002	21307-21317	JJ	denotes	structural
T6003	21375-21378	VBP	denotes	are
T6004	21324-21327	IN	denotes	for
T6005	21328-21331	DT	denotes	the
T6006	21332-21340	NN	denotes	elasticy
T6007	21341-21343	IN	denotes	of
T6008	21344-21347	JJ	denotes	red
T6009	21354-21359	NNS	denotes	cells
T6010	21348-21353	NN	denotes	blood
T6011	21360-21362	IN	denotes	in
T6012	21363-21374	NN	denotes	circulation
T6013	21379-21383	JJ	denotes	long
T6014	21384-21389	NN	denotes	range
T6015	21400-21409	NNS	denotes	functions
T6016	21390-21399	JJ	denotes	molecular
T6017	21410-21412	IN	denotes	of
T6018	21413-21416	DT	denotes	the
T6019	21424-21432	NN	denotes	membrane
T6020	21417-21423	NN	denotes	plasma
T6021	21433-21436	CC	denotes	and
T6022	21437-21440	DT	denotes	the
T6023	21461-21465	NN	denotes	part
T6024	21441-21449	NN	denotes	membrane
T6025	21450-21460	VBN	denotes	associated
T6026	21466-21468	IN	denotes	of
T6027	21469-21472	DT	denotes	the
T6028	21473-21485	NN	denotes	cytoskeleton
T6029	21486-21487	-LRB-	denotes	[
T6030	21487-21489	CD	denotes	40
T6031	21489-21490	SYM	denotes	-
T6032	21490-21492	CD	denotes	43
T6033	21492-21493	-RRB-	denotes	]
T6034	21493-21494	.	denotes	.
T6035	21494-21706	sentence	denotes	Major constituents of the membrane skeleton are spectrin tetramers linked together by short actin filaments and several other proteins covering the entire cytoplasmic surface of the red blood cell membrane [44].
T6036	21495-21500	JJ	denotes	Major
T6037	21501-21513	NNS	denotes	constituents
T6038	21539-21542	VBP	denotes	are
T6039	21514-21516	IN	denotes	of
T6040	21517-21520	DT	denotes	the
T6041	21530-21538	NN	denotes	skeleton
T6042	21521-21529	NN	denotes	membrane
T6043	21543-21551	NN	denotes	spectrin
T6044	21552-21561	NNS	denotes	tetramers
T6045	21562-21568	VBN	denotes	linked
T6046	21569-21577	RB	denotes	together
T6047	21578-21580	IN	denotes	by
T6048	21581-21586	JJ	denotes	short
T6049	21593-21602	NNS	denotes	filaments
T6050	21587-21592	NN	denotes	actin
T6051	21603-21606	CC	denotes	and
T6052	21607-21614	JJ	denotes	several
T6053	21621-21629	NN	denotes	proteins
T6054	21615-21620	JJ	denotes	other
T6055	21630-21638	VBG	denotes	covering
T6056	21639-21642	DT	denotes	the
T6057	21662-21669	NN	denotes	surface
T6058	21643-21649	JJ	denotes	entire
T6059	21650-21661	JJ	denotes	cytoplasmic
T6060	21670-21672	IN	denotes	of
T6061	21673-21676	DT	denotes	the
T6062	21692-21700	NN	denotes	membrane
T6063	21677-21680	JJ	denotes	red
T6064	21687-21691	NN	denotes	cell
T6065	21681-21686	NN	denotes	blood
T6066	21701-21702	-LRB-	denotes	[
T6067	21702-21704	CD	denotes	44
T6068	21704-21705	-RRB-	denotes	]
T6069	21705-21706	.	denotes	.
T6070	21706-21968	sentence	denotes	Membrane cholesterol diminishes red blood cell haemolysis by the complement complex, whereas depletion of raft cholesterol abrogates association of all raft proteins with no significant effect on areas in the rest of the cell membrane and deformability [45,46].
T6071	21707-21715	NN	denotes	Membrane
T6072	21716-21727	NN	denotes	cholesterol
T6073	21728-21738	VBZ	denotes	diminishes
T6074	21739-21742	JJ	denotes	red
T6075	21749-21753	NN	denotes	cell
T6076	21743-21748	NN	denotes	blood
T6077	21754-21764	NN	denotes	haemolysis
T6078	21765-21767	IN	denotes	by
T6079	21768-21771	DT	denotes	the
T6080	21783-21790	NN	denotes	complex
T6081	21772-21782	NN	denotes	complement
T6082	21790-21792	,	denotes	,
T6083	21792-21799	IN	denotes	whereas
T6084	21830-21839	VBZ	denotes	abrogates
T6085	21800-21809	NN	denotes	depletion
T6086	21810-21812	IN	denotes	of
T6087	21813-21817	NN	denotes	raft
T6088	21818-21829	NN	denotes	cholesterol
T6089	21840-21851	NN	denotes	association
T6090	21852-21854	IN	denotes	of
T6091	21855-21858	DT	denotes	all
T6092	21864-21872	NN	denotes	proteins
T6093	21859-21863	NN	denotes	raft
T6094	21873-21877	IN	denotes	with
T6095	21878-21880	DT	denotes	no
T6096	21893-21899	NN	denotes	effect
T6097	21881-21892	JJ	denotes	significant
T6098	21900-21902	IN	denotes	on
T6099	21903-21908	NNS	denotes	areas
T6100	21909-21911	IN	denotes	in
T6101	21912-21915	DT	denotes	the
T6102	21916-21920	NN	denotes	rest
T6103	21921-21923	IN	denotes	of
T6104	21924-21927	DT	denotes	the
T6105	21933-21941	NN	denotes	membrane
T6106	21928-21932	NN	denotes	cell
T6107	21942-21945	CC	denotes	and
T6108	21946-21959	NN	denotes	deformability
T6109	21960-21961	-LRB-	denotes	[
T6110	21964-21966	CD	denotes	46
T6111	21961-21963	CD	denotes	45
T6112	21963-21964	,	denotes	,
T6113	21966-21967	-RRB-	denotes	]
T6114	21967-21968	.	denotes	.
T6115	21968-22072	sentence	denotes	Annexin A7 knock out mouse red blood cells show a more flat shape and have a higher osmotic resistance.
T6116	21969-21976	NN	denotes	Annexin
T6117	21977-21979	NN	denotes	A7
T6118	22006-22011	NNS	denotes	cells
T6119	21980-21985	NN	denotes	knock
T6120	21986-21989	NN	denotes	out
T6121	21990-21995	NN	denotes	mouse
T6122	21996-21999	JJ	denotes	red
T6123	22000-22005	NN	denotes	blood
T6124	22012-22016	VBP	denotes	show
T6125	22017-22018	DT	denotes	a
T6126	22029-22034	NN	denotes	shape
T6127	22019-22023	RBR	denotes	more
T6128	22024-22028	JJ	denotes	flat
T6129	22035-22038	CC	denotes	and
T6130	22039-22043	VBP	denotes	have
T6131	22044-22045	DT	denotes	a
T6132	22061-22071	NN	denotes	resistance
T6133	22046-22052	JJR	denotes	higher
T6134	22053-22060	JJ	denotes	osmotic
T6135	22071-22072	.	denotes	.
T6136	22072-22240	sentence	denotes	The presence of annexin A7 may alter the membrane flexibility in that it supports the typical biconcave membrane shape and leads to a lower minimal osmotic resistance.
T6137	22073-22076	DT	denotes	The
T6138	22077-22085	NN	denotes	presence
T6139	22104-22109	VB	denotes	alter
T6140	22086-22088	IN	denotes	of
T6141	22089-22096	NN	denotes	annexin
T6142	22097-22099	NN	denotes	A7
T6143	22100-22103	MD	denotes	may
T6144	22110-22113	DT	denotes	the
T6145	22123-22134	NN	denotes	flexibility
T6146	22114-22122	NN	denotes	membrane
T6147	22135-22137	IN	denotes	in
T6148	22146-22154	VBZ	denotes	supports
T6149	22138-22142	IN	denotes	that
T6150	22143-22145	PRP	denotes	it
T6151	22155-22158	DT	denotes	the
T6152	22186-22191	NN	denotes	shape
T6153	22159-22166	JJ	denotes	typical
T6154	22167-22176	NN	denotes	biconcave
T6155	22177-22185	NN	denotes	membrane
T6156	22192-22195	CC	denotes	and
T6157	22196-22201	VBZ	denotes	leads
T6158	22202-22204	IN	denotes	to
T6159	22205-22206	DT	denotes	a
T6160	22229-22239	NN	denotes	resistance
T6161	22207-22212	JJR	denotes	lower
T6162	22213-22220	JJ	denotes	minimal
T6163	22221-22228	JJ	denotes	osmotic
T6164	22239-22240	.	denotes	.
T6165	22240-22380	sentence	denotes	Annexin A7 does not appear to have an influence on plasma membrane integrity itself as the maximal osmotic resistance value stays constant.
T6166	22241-22248	NN	denotes	Annexin
T6167	22249-22251	NN	denotes	A7
T6168	22261-22267	VB	denotes	appear
T6169	22252-22256	VBZ	denotes	does
T6170	22257-22260	RB	denotes	not
T6171	22268-22270	TO	denotes	to
T6172	22271-22275	VB	denotes	have
T6173	22276-22278	DT	denotes	an
T6174	22279-22288	NN	denotes	influence
T6175	22289-22291	IN	denotes	on
T6176	22292-22298	NN	denotes	plasma
T6177	22299-22307	NN	denotes	membrane
T6178	22308-22317	NN	denotes	integrity
T6179	22318-22324	PRP	denotes	itself
T6180	22325-22327	IN	denotes	as
T6181	22365-22370	VBZ	denotes	stays
T6182	22328-22331	DT	denotes	the
T6183	22359-22364	NN	denotes	value
T6184	22332-22339	JJ	denotes	maximal
T6185	22340-22347	JJ	denotes	osmotic
T6186	22348-22358	NN	denotes	resistance
T6187	22371-22379	JJ	denotes	constant
T6188	22379-22380	.	denotes	.
T6189	22380-22501	sentence	denotes	Ca2+ and membrane skeletal proteins are known to play key roles on the red blood cell membrane shape and stability [47].
T6190	22381-22385	NN	denotes	Ca2+
T6191	22408-22416	NN	denotes	proteins
T6192	22386-22389	CC	denotes	and
T6193	22390-22398	NN	denotes	membrane
T6194	22399-22407	JJ	denotes	skeletal
T6195	22421-22426	VBN	denotes	known
T6196	22417-22420	VBP	denotes	are
T6197	22427-22429	TO	denotes	to
T6198	22430-22434	VB	denotes	play
T6199	22435-22438	JJ	denotes	key
T6200	22439-22444	NNS	denotes	roles
T6201	22445-22447	IN	denotes	on
T6202	22448-22451	DT	denotes	the
T6203	22476-22481	NN	denotes	shape
T6204	22452-22455	JJ	denotes	red
T6205	22462-22466	NN	denotes	cell
T6206	22456-22461	NN	denotes	blood
T6207	22467-22475	NN	denotes	membrane
T6208	22482-22485	CC	denotes	and
T6209	22486-22495	NN	denotes	stability
T6210	22496-22497	-LRB-	denotes	[
T6211	22497-22499	CD	denotes	47
T6212	22499-22500	-RRB-	denotes	]
T6213	22500-22501	.	denotes	.
T6214	22501-22616	sentence	denotes	Annexins have been reported to bind directly to F-actin, we could however exclude such an activity for annexin A7.
T6215	22502-22510	NNS	denotes	Annexins
T6216	22521-22529	VBN	denotes	reported
T6217	22511-22515	VBP	denotes	have
T6218	22516-22520	VBN	denotes	been
T6219	22576-22583	VB	denotes	exclude
T6220	22530-22532	TO	denotes	to
T6221	22533-22537	VB	denotes	bind
T6222	22538-22546	RB	denotes	directly
T6223	22547-22549	IN	denotes	to
T6224	22550-22551	NN	denotes	F
T6225	22552-22557	NN	denotes	actin
T6226	22551-22552	HYPH	denotes	-
T6227	22557-22559	,	denotes	,
T6228	22559-22561	PRP	denotes	we
T6229	22562-22567	MD	denotes	could
T6230	22568-22575	RB	denotes	however
T6231	22584-22588	JJ	denotes	such
T6232	22592-22600	NN	denotes	activity
T6233	22589-22591	DT	denotes	an
T6234	22601-22604	IN	denotes	for
T6235	22605-22612	NN	denotes	annexin
T6236	22613-22615	NN	denotes	A7
T6237	22615-22616	.	denotes	.
T6238	22616-22877	sentence	denotes	Nevertheless it might interact with other components and have a role in organizing the membrane cytoskeleton, controlling raft protein associations or influencing the ionic strength of red blood cells on its own or by interfering with other signaling pathways.
T6239	22617-22629	RB	denotes	Nevertheless
T6240	22639-22647	VB	denotes	interact
T6241	22630-22632	PRP	denotes	it
T6242	22633-22638	MD	denotes	might
T6243	22648-22652	IN	denotes	with
T6244	22653-22658	JJ	denotes	other
T6245	22659-22669	NNS	denotes	components
T6246	22670-22673	CC	denotes	and
T6247	22674-22678	VBP	denotes	have
T6248	22679-22680	DT	denotes	a
T6249	22681-22685	NN	denotes	role
T6250	22686-22688	IN	denotes	in
T6251	22689-22699	VBG	denotes	organizing
T6252	22700-22703	DT	denotes	the
T6253	22713-22725	NN	denotes	cytoskeleton
T6254	22704-22712	NN	denotes	membrane
T6255	22725-22727	,	denotes	,
T6256	22727-22738	VBG	denotes	controlling
T6257	22739-22743	NN	denotes	raft
T6258	22744-22751	NN	denotes	protein
T6259	22752-22764	NNS	denotes	associations
T6260	22765-22767	CC	denotes	or
T6261	22768-22779	VBG	denotes	influencing
T6262	22780-22783	DT	denotes	the
T6263	22790-22798	NN	denotes	strength
T6264	22784-22789	JJ	denotes	ionic
T6265	22799-22801	IN	denotes	of
T6266	22802-22805	JJ	denotes	red
T6267	22812-22817	NNS	denotes	cells
T6268	22806-22811	NN	denotes	blood
T6269	22818-22820	IN	denotes	on
T6270	22821-22824	PRP$	denotes	its
T6271	22825-22828	JJ	denotes	own
T6272	22829-22831	CC	denotes	or
T6273	22832-22834	IN	denotes	by
T6274	22835-22846	VBG	denotes	interfering
T6275	22847-22851	IN	denotes	with
T6276	22852-22857	JJ	denotes	other
T6277	22868-22876	NNS	denotes	pathways
T6278	22858-22867	NN	denotes	signaling
T6279	22876-22877	.	denotes	.
T6280	22877-22962	sentence	denotes	As discussed above annexin A7 could be involved in the cytoplasmic Ca2+ homeostasis.
T6281	22878-22880	IN	denotes	As
T6282	22881-22890	VBN	denotes	discussed
T6283	22917-22925	VBN	denotes	involved
T6284	22891-22896	RB	denotes	above
T6285	22897-22904	NN	denotes	annexin
T6286	22905-22907	NN	denotes	A7
T6287	22908-22913	MD	denotes	could
T6288	22914-22916	VB	denotes	be
T6289	22926-22928	IN	denotes	in
T6290	22929-22932	DT	denotes	the
T6291	22950-22961	NN	denotes	homeostasis
T6292	22933-22944	JJ	denotes	cytoplasmic
T6293	22945-22949	NN	denotes	Ca2+
T6294	22961-22962	.	denotes	.
T6295	22962-23154	sentence	denotes	It has been demonstrated that micromolar changes of the intracellular Ca2+ concentration exert a profound effect on the membrane properties that regulate red blood cell deformability [48,49].
T6296	22963-22965	PRP	denotes	It
T6297	22975-22987	VBN	denotes	demonstrated
T6298	22966-22969	VBZ	denotes	has
T6299	22970-22974	VBN	denotes	been
T6300	22988-22992	IN	denotes	that
T6301	23052-23057	VBP	denotes	exert
T6302	22993-23003	JJ	denotes	micromolar
T6303	23004-23011	NNS	denotes	changes
T6304	23012-23014	IN	denotes	of
T6305	23015-23018	DT	denotes	the
T6306	23038-23051	NN	denotes	concentration
T6307	23019-23032	JJ	denotes	intracellular
T6308	23033-23037	NN	denotes	Ca2+
T6309	23058-23059	DT	denotes	a
T6310	23069-23075	NN	denotes	effect
T6311	23060-23068	JJ	denotes	profound
T6312	23076-23078	IN	denotes	on
T6313	23079-23082	DT	denotes	the
T6314	23092-23102	NNS	denotes	properties
T6315	23083-23091	NN	denotes	membrane
T6316	23103-23107	WDT	denotes	that
T6317	23108-23116	VBP	denotes	regulate
T6318	23117-23120	JJ	denotes	red
T6319	23127-23131	NN	denotes	cell
T6320	23121-23126	NN	denotes	blood
T6321	23132-23145	NN	denotes	deformability
T6322	23146-23147	-LRB-	denotes	[
T6323	23150-23152	CD	denotes	49
T6324	23147-23149	CD	denotes	48
T6325	23149-23150	,	denotes	,
T6326	23152-23153	-RRB-	denotes	]
T6327	23153-23154	.	denotes	.
T6328	23154-23297	sentence	denotes	Furthermore, the intracellular Ca2+ was shown to regulate the membrane stability through modulation of cytoskeletal protein interactions [50].
T6329	23155-23166	RB	denotes	Furthermore
T6330	23195-23200	VBN	denotes	shown
T6331	23166-23168	,	denotes	,
T6332	23168-23171	DT	denotes	the
T6333	23186-23190	NN	denotes	Ca2+
T6334	23172-23185	JJ	denotes	intracellular
T6335	23191-23194	VBD	denotes	was
T6336	23201-23203	TO	denotes	to
T6337	23204-23212	VB	denotes	regulate
T6338	23213-23216	DT	denotes	the
T6339	23226-23235	NN	denotes	stability
T6340	23217-23225	NN	denotes	membrane
T6341	23236-23243	IN	denotes	through
T6342	23244-23254	NN	denotes	modulation
T6343	23255-23257	IN	denotes	of
T6344	23258-23270	JJ	denotes	cytoskeletal
T6345	23271-23278	NN	denotes	protein
T6346	23279-23291	NNS	denotes	interactions
T6347	23292-23293	-LRB-	denotes	[
T6348	23293-23295	CD	denotes	50
T6349	23295-23296	-RRB-	denotes	]
T6350	23296-23297	.	denotes	.
T6351	23297-23407	sentence	denotes	Ca2+ also induces a transbilayer phospholipid redistribution inducing a shape change of red blood cells [51].
T6352	23298-23302	NN	denotes	Ca2+
T6353	23308-23315	VBZ	denotes	induces
T6354	23303-23307	RB	denotes	also
T6355	23316-23317	DT	denotes	a
T6356	23344-23358	NN	denotes	redistribution
T6357	23318-23330	NN	denotes	transbilayer
T6358	23331-23343	NN	denotes	phospholipid
T6359	23359-23367	VBG	denotes	inducing
T6360	23368-23369	DT	denotes	a
T6361	23376-23382	NN	denotes	change
T6362	23370-23375	NN	denotes	shape
T6363	23383-23385	IN	denotes	of
T6364	23386-23389	JJ	denotes	red
T6365	23396-23401	NNS	denotes	cells
T6366	23390-23395	NN	denotes	blood
T6367	23402-23403	-LRB-	denotes	[
T6368	23403-23405	CD	denotes	51
T6369	23405-23406	-RRB-	denotes	]
T6370	23406-23407	.	denotes	.
T6371	23407-23517	sentence	denotes	In addition, Ca2+ ions can drive spiculation of the membrane bilayer without involving the cytoskeleton [52].
T6372	23408-23410	IN	denotes	In
T6373	23435-23440	VB	denotes	drive
T6374	23411-23419	NN	denotes	addition
T6375	23419-23421	,	denotes	,
T6376	23421-23425	NN	denotes	Ca2+
T6377	23426-23430	NNS	denotes	ions
T6378	23431-23434	MD	denotes	can
T6379	23441-23452	NN	denotes	spiculation
T6380	23453-23455	IN	denotes	of
T6381	23456-23459	DT	denotes	the
T6382	23469-23476	NN	denotes	bilayer
T6383	23460-23468	NN	denotes	membrane
T6384	23477-23484	IN	denotes	without
T6385	23485-23494	VBG	denotes	involving
T6386	23495-23498	DT	denotes	the
T6387	23499-23511	NN	denotes	cytoskeleton
T6388	23512-23513	-LRB-	denotes	[
T6389	23513-23515	CD	denotes	52
T6390	23515-23516	-RRB-	denotes	]
T6391	23516-23517	.	denotes	.
T6392	23517-23595	sentence	denotes	We have also observed a defect in platelet function in the annexin A7 mutant.
T6393	23518-23520	PRP	denotes	We
T6394	23531-23539	VBN	denotes	observed
T6395	23521-23525	VBP	denotes	have
T6396	23526-23530	RB	denotes	also
T6397	23540-23541	DT	denotes	a
T6398	23542-23548	NN	denotes	defect
T6399	23549-23551	IN	denotes	in
T6400	23552-23560	NN	denotes	platelet
T6401	23561-23569	NN	denotes	function
T6402	23570-23572	IN	denotes	in
T6403	23573-23576	DT	denotes	the
T6404	23588-23594	NN	denotes	mutant
T6405	23577-23584	NN	denotes	annexin
T6406	23585-23587	NN	denotes	A7
T6407	23594-23595	.	denotes	.
T6408	23595-23739	sentence	denotes	In the platelet aggregation experiments the initial aggregation velocity was slightly, but significantly lower in platelets lacking annexin A7.
T6409	23596-23598	IN	denotes	In
T6410	23669-23672	VBD	denotes	was
T6411	23599-23602	DT	denotes	the
T6412	23624-23635	NNS	denotes	experiments
T6413	23603-23611	NN	denotes	platelet
T6414	23612-23623	NN	denotes	aggregation
T6415	23636-23639	DT	denotes	the
T6416	23660-23668	NN	denotes	velocity
T6417	23640-23647	JJ	denotes	initial
T6418	23648-23659	NN	denotes	aggregation
T6419	23673-23681	RB	denotes	slightly
T6420	23701-23706	JJR	denotes	lower
T6421	23681-23683	,	denotes	,
T6422	23683-23686	CC	denotes	but
T6423	23687-23700	RB	denotes	significantly
T6424	23707-23709	IN	denotes	in
T6425	23710-23719	NNS	denotes	platelets
T6426	23720-23727	VBG	denotes	lacking
T6427	23728-23735	NN	denotes	annexin
T6428	23736-23738	NN	denotes	A7
T6429	23738-23739	.	denotes	.
T6430	23739-23810	sentence	denotes	These data are not reflected by a change in the in vivo bleeding time.
T6431	23740-23745	DT	denotes	These
T6432	23746-23750	NNS	denotes	data
T6433	23759-23768	VBN	denotes	reflected
T6434	23751-23754	VBP	denotes	are
T6435	23755-23758	RB	denotes	not
T6436	23769-23771	IN	denotes	by
T6437	23772-23773	DT	denotes	a
T6438	23774-23780	NN	denotes	change
T6439	23781-23783	IN	denotes	in
T6440	23784-23787	DT	denotes	the
T6441	23805-23809	NN	denotes	time
T6442	23788-23790	FW	denotes	in
T6443	23791-23795	FW	denotes	vivo
T6444	23796-23804	NN	denotes	bleeding
T6445	23809-23810	.	denotes	.
T6446	23810-23981	sentence	denotes	However the reaction speed of murine platelets is much higher than those of human and due to the technical setup we might have missed larger changes in the mouse samples.
T6447	23811-23818	RB	denotes	However
T6448	23858-23860	VBZ	denotes	is
T6449	23819-23822	DT	denotes	the
T6450	23832-23837	NN	denotes	speed
T6451	23823-23831	NN	denotes	reaction
T6452	23838-23840	IN	denotes	of
T6453	23841-23847	JJ	denotes	murine
T6454	23848-23857	NNS	denotes	platelets
T6455	23861-23865	RB	denotes	much
T6456	23866-23872	JJR	denotes	higher
T6457	23873-23877	IN	denotes	than
T6458	23878-23883	DT	denotes	those
T6459	23884-23886	IN	denotes	of
T6460	23887-23892	JJ	denotes	human
T6461	23893-23896	CC	denotes	and
T6462	23897-23900	IN	denotes	due
T6463	23938-23944	VBN	denotes	missed
T6464	23901-23903	IN	denotes	to
T6465	23904-23907	DT	denotes	the
T6466	23918-23923	NN	denotes	setup
T6467	23908-23917	JJ	denotes	technical
T6468	23924-23926	PRP	denotes	we
T6469	23927-23932	MD	denotes	might
T6470	23933-23937	VB	denotes	have
T6471	23945-23951	JJR	denotes	larger
T6472	23952-23959	NNS	denotes	changes
T6473	23960-23962	IN	denotes	in
T6474	23963-23966	DT	denotes	the
T6475	23973-23980	NNS	denotes	samples
T6476	23967-23972	NN	denotes	mouse
T6477	23980-23981	.	denotes	.
T6478	23981-24139	sentence	denotes	The immediate reaction of mouse platelets and the absence of a lag phase after triggering may be caused by an immediately initiated thrombin generation [22].
T6479	23982-23985	DT	denotes	The
T6480	23996-24004	NN	denotes	reaction
T6481	23986-23995	JJ	denotes	immediate
T6482	24079-24085	VBN	denotes	caused
T6483	24005-24007	IN	denotes	of
T6484	24008-24013	NN	denotes	mouse
T6485	24014-24023	NNS	denotes	platelets
T6486	24024-24027	CC	denotes	and
T6487	24028-24031	DT	denotes	the
T6488	24032-24039	NN	denotes	absence
T6489	24040-24042	IN	denotes	of
T6490	24043-24044	DT	denotes	a
T6491	24049-24054	NN	denotes	phase
T6492	24045-24048	NN	denotes	lag
T6493	24055-24060	IN	denotes	after
T6494	24061-24071	NN	denotes	triggering
T6495	24072-24075	MD	denotes	may
T6496	24076-24078	VB	denotes	be
T6497	24086-24088	IN	denotes	by
T6498	24089-24091	DT	denotes	an
T6499	24123-24133	NN	denotes	generation
T6500	24092-24103	RB	denotes	immediately
T6501	24104-24113	VBN	denotes	initiated
T6502	24114-24122	NN	denotes	thrombin
T6503	24134-24135	-LRB-	denotes	[
T6504	24135-24137	CD	denotes	22
T6505	24137-24138	-RRB-	denotes	]
T6506	24138-24139	.	denotes	.
T6507	24139-24326	sentence	denotes	As known from the frequent human vWF-syndrome or other haemostatic diseases, small defects often are clinically silent and do not result in physiological changes under normal conditions.
T6508	24140-24142	IN	denotes	As
T6509	24143-24148	VBN	denotes	known
T6510	24237-24240	VBP	denotes	are
T6511	24149-24153	IN	denotes	from
T6512	24154-24157	DT	denotes	the
T6513	24177-24185	NN	denotes	syndrome
T6514	24158-24166	JJ	denotes	frequent
T6515	24167-24172	JJ	denotes	human
T6516	24173-24176	NN	denotes	vWF
T6517	24176-24177	HYPH	denotes	-
T6518	24186-24188	CC	denotes	or
T6519	24189-24194	JJ	denotes	other
T6520	24207-24215	NNS	denotes	diseases
T6521	24195-24206	JJ	denotes	haemostatic
T6522	24215-24217	,	denotes	,
T6523	24217-24222	JJ	denotes	small
T6524	24223-24230	NNS	denotes	defects
T6525	24231-24236	RB	denotes	often
T6526	24241-24251	RB	denotes	clinically
T6527	24252-24258	JJ	denotes	silent
T6528	24259-24262	CC	denotes	and
T6529	24263-24265	VBP	denotes	do
T6530	24270-24276	VB	denotes	result
T6531	24266-24269	RB	denotes	not
T6532	24277-24279	IN	denotes	in
T6533	24280-24293	JJ	denotes	physiological
T6534	24294-24301	NNS	denotes	changes
T6535	24302-24307	IN	denotes	under
T6536	24308-24314	JJ	denotes	normal
T6537	24315-24325	NNS	denotes	conditions
T6538	24325-24326	.	denotes	.
T6539	24326-24521	sentence	denotes	Only in situations with severe physical injury, distinct environmental influences or additional platelet attributes like the platelet antigen polymorphism [53] differences might become apparent.
T6540	24327-24331	RB	denotes	Only
T6541	24332-24334	IN	denotes	in
T6542	24505-24511	VB	denotes	become
T6543	24335-24345	NNS	denotes	situations
T6544	24346-24350	IN	denotes	with
T6545	24351-24357	JJ	denotes	severe
T6546	24367-24373	NN	denotes	injury
T6547	24358-24366	JJ	denotes	physical
T6548	24373-24375	,	denotes	,
T6549	24375-24383	JJ	denotes	distinct
T6550	24398-24408	NNS	denotes	influences
T6551	24384-24397	JJ	denotes	environmental
T6552	24409-24411	CC	denotes	or
T6553	24412-24422	JJ	denotes	additional
T6554	24423-24431	NN	denotes	platelet
T6555	24432-24442	VBZ	denotes	attributes
T6643	24535-24537	IN	denotes	In
T6644	24552-24558	VBP	denotes	report
T6645	24538-24542	DT	denotes	this
T6646	24543-24548	NN	denotes	paper
T6647	24549-24551	PRP	denotes	we
T6648	24559-24562	DT	denotes	the
T6649	24563-24571	NN	denotes	presence
T6650	24572-24574	IN	denotes	of
T6651	24575-24579	CC	denotes	both
T6652	24591-24599	NNS	denotes	isoforms
T6653	24580-24587	NN	denotes	annexin
T6654	24588-24590	NN	denotes	A7
T6655	24600-24602	IN	denotes	in
T6656	24603-24606	JJ	denotes	red
T6657	24613-24618	NNS	denotes	cells
T6658	24607-24612	NN	denotes	blood
T6659	24619-24624	WRB	denotes	where
T6660	24630-24633	VBP	denotes	are
T6661	24625-24629	PRP	denotes	they
T6662	24634-24642	JJ	denotes	abundant
T6663	24643-24645	IN	denotes	in
T6664	24646-24658	NNS	denotes	nanovesicles
T6665	24659-24663	WDT	denotes	that
T6666	24664-24668	VBP	denotes	form
T6667	24669-24673	IN	denotes	upon
T6668	24674-24678	NN	denotes	Ca2+
T6669	24679-24687	NN	denotes	addition
T6670	24687-24688	.	denotes	.
T6671	24688-24756	sentence	denotes	The proteins are however not required for the vesiculation process.
T6672	24689-24692	DT	denotes	The
T6673	24693-24701	NN	denotes	proteins
T6674	24718-24726	VBN	denotes	required
T6675	24702-24705	VBP	denotes	are
T6676	24706-24713	RB	denotes	however
T6677	24714-24717	RB	denotes	not
T6678	24727-24730	IN	denotes	for
T6679	24731-24734	DT	denotes	the
T6680	24748-24755	NN	denotes	process
T6681	24735-24747	NN	denotes	vesiculation
T6682	24755-24756	.	denotes	.
T6683	24756-25020	sentence	denotes	They are also not essential for the formation of specific membrane domains such as lipid rafts, as exogenously added recombinant annexin A7 redistributed to similar positions in a density gradient containing membranes derived from red blood cells of anxA7-/-mice.
T6684	24757-24761	PRP	denotes	They
T6685	24762-24765	VBP	denotes	are
T6686	24766-24770	RB	denotes	also
T6687	24771-24774	RB	denotes	not
T6688	24775-24784	JJ	denotes	essential
T6689	24785-24788	IN	denotes	for
T6690	24789-24792	DT	denotes	the
T6691	24793-24802	NN	denotes	formation
T6692	24803-24805	IN	denotes	of
T6693	24806-24814	JJ	denotes	specific
T6694	24824-24831	NNS	denotes	domains
T6695	24815-24823	NN	denotes	membrane
T6696	24832-24836	JJ	denotes	such
T6697	24837-24839	IN	denotes	as
T6698	24840-24845	NN	denotes	lipid
T6699	24846-24851	NNS	denotes	rafts
T6700	24851-24853	,	denotes	,
T6701	24853-24855	IN	denotes	as
T6702	24856-24867	RB	denotes	exogenously
T6703	24868-24873	VBN	denotes	added
T6704	24894-24896	NN	denotes	A7
T6705	24874-24885	JJ	denotes	recombinant
T6706	24886-24893	NN	denotes	annexin
T6707	24897-24910	VBN	denotes	redistributed
T6708	24911-24913	IN	denotes	to
T6709	24914-24921	JJ	denotes	similar
T6710	24922-24931	NNS	denotes	positions
T6711	24932-24934	IN	denotes	in
T6712	24935-24936	DT	denotes	a
T6713	24945-24953	NN	denotes	gradient
T6714	24937-24944	NN	denotes	density
T6715	24954-24964	VBG	denotes	containing
T6716	24965-24974	NNS	denotes	membranes
T6717	24975-24982	VBN	denotes	derived
T6718	24983-24987	IN	denotes	from
T6719	24988-24991	JJ	denotes	red
T6720	24998-25003	NNS	denotes	cells
T6721	24992-24997	NN	denotes	blood
T6722	25004-25006	IN	denotes	of
T6723	25007-25012	NN	denotes	anxA7
T6724	25015-25019	NNS	denotes	mice
T6725	25012-25013	SYM	denotes	-
T6726	25013-25014	HYPH	denotes	/
T6727	25014-25015	SYM	denotes	-
T6728	25019-25020	.	denotes	.
T6729	25020-25147	sentence	denotes	The observed cell shape change of erythrocytes lacking annexin A7 might be due to alterations in the erythrocyte cytoskeleton.
T6730	25021-25024	DT	denotes	The
T6731	25045-25051	NN	denotes	change
T6732	25025-25033	VBN	denotes	observed
T6733	25034-25038	NN	denotes	cell
T6734	25039-25044	NN	denotes	shape
T6735	25093-25095	VB	denotes	be
T6736	25052-25054	IN	denotes	of
T6737	25055-25067	NNS	denotes	erythrocytes
T6738	25068-25075	VBG	denotes	lacking
T6739	25076-25083	NN	denotes	annexin
T6740	25084-25086	NN	denotes	A7
T6741	25087-25092	MD	denotes	might
T6742	25096-25099	IN	denotes	due
T6743	25100-25102	IN	denotes	to
T6744	25103-25114	NNS	denotes	alterations
T6745	25115-25117	IN	denotes	in
T6746	25118-25121	DT	denotes	the
T6747	25134-25146	NN	denotes	cytoskeleton
T6748	25122-25133	NN	denotes	erythrocyte
T6749	25146-25147	.	denotes	.
T6750	25147-25265	sentence	denotes	As a direct interaction with F-actin was ruled out, this effect might be mediated by annexin's Ca2+-binding activity.
T6751	25148-25150	IN	denotes	As
T6752	25189-25194	VBN	denotes	ruled
T6753	25151-25152	DT	denotes	a
T6754	25160-25171	NN	denotes	interaction
T6755	25153-25159	JJ	denotes	direct
T6756	25172-25176	IN	denotes	with
T6757	25177-25178	NN	denotes	F
T6758	25179-25184	NN	denotes	actin
T6759	25178-25179	HYPH	denotes	-
T6760	25185-25188	VBD	denotes	was
T6761	25221-25229	VBN	denotes	mediated
T6762	25195-25198	RP	denotes	out
T6763	25198-25200	,	denotes	,
T6764	25200-25204	DT	denotes	this
T6765	25205-25211	NN	denotes	effect
T6766	25212-25217	MD	denotes	might
T6767	25218-25220	VB	denotes	be
T6768	25230-25232	IN	denotes	by
T6769	25233-25240	NN	denotes	annexin
T6770	25256-25264	NN	denotes	activity
T6771	25240-25242	POS	denotes	's
T6772	25243-25247	NN	denotes	Ca2+
T6773	25248-25255	VBG	denotes	binding
T6774	25247-25248	HYPH	denotes	-
T6775	25264-25265	.	denotes	.
T6879	25276-25287	NN	denotes	Acquisition
T6880	25288-25290	IN	denotes	of
T6881	25291-25297	JJ	denotes	murine
T6882	25308-25313	NN	denotes	blood
T6883	25298-25301	CC	denotes	and
T6884	25302-25307	JJ	denotes	human
T6885	25314-25321	NNS	denotes	samples
T6886	25321-25609	sentence	denotes	Blood from 129Sv wild type and annexin A7 knock out mice (anxA7-/-) kept under pathogen-free conditions and fed with regular food, was collected in 1 ml syringes with a 22 gauge needle punctating the right cardiac ventricle immediately after they had been killed by cervical dislocation.
T6887	25322-25327	NN	denotes	Blood
T6888	25457-25466	VBN	denotes	collected
T6889	25328-25332	IN	denotes	from
T6890	25333-25338	NN	denotes	129Sv
T6891	25374-25378	NNS	denotes	mice
T6892	25339-25343	JJ	denotes	wild
T6893	25344-25348	NN	denotes	type
T6894	25349-25352	CC	denotes	and
T6895	25353-25360	NN	denotes	annexin
T6896	25361-25363	NN	denotes	A7
T6897	25364-25369	NN	denotes	knock
T6898	25370-25373	NN	denotes	out
T6899	25379-25380	-LRB-	denotes	(
T6900	25380-25385	NN	denotes	anxA7
T6901	25385-25386	SYM	denotes	-
T6902	25386-25387	HYPH	denotes	/
T6903	25387-25388	SYM	denotes	-
T6904	25388-25389	-RRB-	denotes	)
T6905	25390-25394	VBN	denotes	kept
T6906	25395-25400	IN	denotes	under
T6907	25401-25409	NN	denotes	pathogen
T6908	25410-25414	JJ	denotes	free
T6909	25409-25410	HYPH	denotes	-
T6910	25415-25425	NNS	denotes	conditions
T6911	25426-25429	CC	denotes	and
T6912	25430-25433	VBN	denotes	fed
T6913	25434-25438	IN	denotes	with
T6914	25439-25446	JJ	denotes	regular
T6915	25447-25451	NN	denotes	food
T6916	25451-25453	,	denotes	,
T6917	25453-25456	VBD	denotes	was
T6918	25467-25469	IN	denotes	in
T6919	25470-25471	CD	denotes	1
T6920	25472-25474	NN	denotes	ml
T6921	25475-25483	NNS	denotes	syringes
T6922	25484-25488	IN	denotes	with
T6923	25489-25490	DT	denotes	a
T6924	25500-25506	NN	denotes	needle
T6925	25491-25493	CD	denotes	22
T6926	25494-25499	NN	denotes	gauge
T6927	25507-25517	VBG	denotes	punctating
T6928	25518-25521	DT	denotes	the
T6929	25536-25545	NN	denotes	ventricle
T6930	25522-25527	JJ	denotes	right
T6931	25528-25535	JJ	denotes	cardiac
T6932	25546-25557	RB	denotes	immediately
T6933	25578-25584	VBN	denotes	killed
T6934	25558-25563	IN	denotes	after
T6935	25564-25568	PRP	denotes	they
T6936	25569-25572	VBD	denotes	had
T6937	25573-25577	VBN	denotes	been
T6938	25585-25587	IN	denotes	by
T6939	25588-25596	JJ	denotes	cervical
T6940	25597-25608	NN	denotes	dislocation
T6941	25608-25609	.	denotes	.
T6942	25609-25719	sentence	denotes	Coagulation generally was inhibited with 1/10 volume of 10 mM NaEDTA, pH 7.5, already present in the syringe.
T6943	25610-25621	NN	denotes	Coagulation
T6944	25636-25645	VBN	denotes	inhibited
T6945	25622-25631	RB	denotes	generally
T6946	25632-25635	VBD	denotes	was
T6947	25646-25650	IN	denotes	with
T6948	25651-25652	CD	denotes	1
T6949	25653-25655	CD	denotes	10
T6950	25652-25653	SYM	denotes	/
T6951	25656-25662	NN	denotes	volume
T6952	25663-25665	IN	denotes	of
T6953	25666-25668	CD	denotes	10
T6954	25669-25671	NN	denotes	mM
T6955	25672-25678	NN	denotes	NaEDTA
T6956	25678-25680	,	denotes	,
T6957	25680-25682	NN	denotes	pH
T6958	25683-25686	CD	denotes	7.5
T6959	25686-25688	,	denotes	,
T6960	25688-25695	RB	denotes	already
T6961	25696-25703	JJ	denotes	present
T6962	25704-25706	IN	denotes	in
T6963	25707-25710	DT	denotes	the
T6964	25711-25718	NN	denotes	syringe
T6965	25718-25719	.	denotes	.
T6966	25719-25839	sentence	denotes	The mice were killed by cervical dislocation in order to avoid any effect of anaesthetic chemicals on blood parameters.
T6967	25720-25723	DT	denotes	The
T6968	25724-25728	NNS	denotes	mice
T6969	25734-25740	VBN	denotes	killed
T6970	25729-25733	VBD	denotes	were
T6971	25741-25743	IN	denotes	by
T6972	25744-25752	JJ	denotes	cervical
T6973	25753-25764	NN	denotes	dislocation
T6974	25765-25767	IN	denotes	in
T6975	25768-25773	NN	denotes	order
T6976	25774-25776	TO	denotes	to
T6977	25777-25782	VB	denotes	avoid
T6978	25783-25786	DT	denotes	any
T6979	25787-25793	NN	denotes	effect
T6980	25794-25796	IN	denotes	of
T6981	25797-25808	JJ	denotes	anaesthetic
T6982	25809-25818	NNS	denotes	chemicals
T6983	25819-25821	IN	denotes	on
T6984	25822-25827	NN	denotes	blood
T6985	25828-25838	NNS	denotes	parameters
T6986	25838-25839	.	denotes	.
T6987	25839-25919	sentence	denotes	The wild type and mutant mice were matched regarding their age, weight and sex.
T6988	25840-25843	DT	denotes	The
T6989	25865-25869	NNS	denotes	mice
T6990	25844-25848	JJ	denotes	wild
T6991	25849-25853	NN	denotes	type
T6992	25854-25857	CC	denotes	and
T6993	25858-25864	JJ	denotes	mutant
T6994	25875-25882	VBN	denotes	matched
T6995	25870-25874	VBD	denotes	were
T6996	25883-25892	VBG	denotes	regarding
T6997	25893-25898	PRP$	denotes	their
T6998	25899-25902	NN	denotes	age
T6999	25902-25904	,	denotes	,
T7000	25904-25910	NN	denotes	weight
T7001	25911-25914	CC	denotes	and
T7002	25915-25918	NN	denotes	sex
T7003	25918-25919	.	denotes	.
T7004	25919-26031	sentence	denotes	The daytime of blood collection, sampling site and collection method were kept constant during all experiments.
T7005	25920-25923	DT	denotes	The
T7006	25924-25931	NN	denotes	daytime
T7007	25994-25998	VBN	denotes	kept
T7008	25932-25934	IN	denotes	of
T7009	25935-25940	NN	denotes	blood
T7010	25941-25951	NN	denotes	collection
T7011	25951-25953	,	denotes	,
T7012	25953-25961	VBG	denotes	sampling
T7013	25962-25966	NN	denotes	site
T7014	25967-25970	CC	denotes	and
T7015	25971-25981	NN	denotes	collection
T7016	25982-25988	NN	denotes	method
T7017	25989-25993	VBD	denotes	were
T7018	25999-26007	JJ	denotes	constant
T7019	26008-26014	IN	denotes	during
T7020	26015-26018	DT	denotes	all
T7021	26019-26030	NNS	denotes	experiments
T7022	26030-26031	.	denotes	.
T7023	26031-26136	sentence	denotes	A typical murine blood sample volume consisted of 550 μl, with variations ranging from 200 μl to 900 μl.
T7024	26032-26033	DT	denotes	A
T7025	26062-26068	NN	denotes	volume
T7026	26034-26041	JJ	denotes	typical
T7027	26042-26048	JJ	denotes	murine
T7028	26055-26061	NN	denotes	sample
T7029	26049-26054	NN	denotes	blood
T7030	26069-26078	VBD	denotes	consisted
T7031	26079-26081	IN	denotes	of
T7032	26082-26085	CD	denotes	550
T7033	26086-26088	NN	denotes	μl
T7034	26088-26090	,	denotes	,
T7035	26090-26094	IN	denotes	with
T7036	26095-26105	NNS	denotes	variations
T7037	26106-26113	VBG	denotes	ranging
T7038	26114-26118	IN	denotes	from
T7039	26119-26122	CD	denotes	200
T7040	26123-26125	NNS	denotes	μl
T7041	26126-26128	IN	denotes	to
T7042	26129-26132	CD	denotes	900
T7043	26133-26135	NNS	denotes	μl
T7044	26135-26136	.	denotes	.
T7045	26136-26246	sentence	denotes	Human blood samples from the authors were collected by vein puncture using common EDTA-monovettes (Sarstedt).
T7046	26137-26142	JJ	denotes	Human
T7047	26149-26156	NNS	denotes	samples
T7048	26143-26148	NN	denotes	blood
T7049	26179-26188	VBN	denotes	collected
T7050	26157-26161	IN	denotes	from
T7051	26162-26165	DT	denotes	the
T7052	26166-26173	NNS	denotes	authors
T7053	26174-26178	VBD	denotes	were
T7054	26189-26191	IN	denotes	by
T7055	26192-26196	NN	denotes	vein
T7056	26197-26205	NN	denotes	puncture
T7057	26206-26211	VBG	denotes	using
T7058	26212-26218	JJ	denotes	common
T7059	26224-26234	NNS	denotes	monovettes
T7060	26219-26223	NN	denotes	EDTA
T7061	26223-26224	HYPH	denotes	-
T7062	26235-26236	-LRB-	denotes	(
T7063	26236-26244	NNP	denotes	Sarstedt
T7064	26244-26245	-RRB-	denotes	)
T7065	26245-26246	.	denotes	.
T7066	26246-26439	sentence	denotes	We performed our studies using well standardized sampling conditions, as differences in the blood sampling site, for example between tail and heart, show large changes in all cell type counts.
T7067	26247-26249	PRP	denotes	We
T7068	26250-26259	VBD	denotes	performed
T7069	26260-26263	PRP$	denotes	our
T7070	26264-26271	NNS	denotes	studies
T7071	26272-26277	VBG	denotes	using
T7072	26278-26282	RB	denotes	well
T7073	26283-26295	JJ	denotes	standardized
T7074	26305-26315	NNS	denotes	conditions
T7075	26296-26304	NN	denotes	sampling
T7076	26315-26317	,	denotes	,
T7077	26317-26319	IN	denotes	as
T7078	26396-26400	VBP	denotes	show
T7079	26320-26331	NNS	denotes	differences
T7080	26332-26334	IN	denotes	in
T7081	26335-26338	DT	denotes	the
T7082	26354-26358	NN	denotes	site
T7083	26339-26344	NN	denotes	blood
T7084	26345-26353	NN	denotes	sampling
T7085	26358-26360	,	denotes	,
T7086	26360-26363	IN	denotes	for
T7087	26372-26379	IN	denotes	between
T7088	26364-26371	NN	denotes	example
T7089	26380-26384	NN	denotes	tail
T7090	26385-26388	CC	denotes	and
T7091	26389-26394	NN	denotes	heart
T7092	26394-26396	,	denotes	,
T7093	26401-26406	JJ	denotes	large
T7094	26407-26414	NNS	denotes	changes
T7095	26415-26417	IN	denotes	in
T7096	26418-26421	DT	denotes	all
T7097	26432-26438	NNS	denotes	counts
T7098	26422-26426	NN	denotes	cell
T7099	26427-26431	NN	denotes	type
T7100	26438-26439	.	denotes	.
T7101	26439-26505	sentence	denotes	First and second sample draw affect blood measurements, too [22].
T7102	26440-26445	JJ	denotes	First
T7103	26464-26468	NN	denotes	draw
T7104	26446-26449	CC	denotes	and
T7105	26450-26456	JJ	denotes	second
T7106	26457-26463	NN	denotes	sample
T7107	26469-26475	VBP	denotes	affect
T7108	26476-26481	NN	denotes	blood
T7109	26482-26494	NNS	denotes	measurements
T7110	26494-26496	,	denotes	,
T7111	26496-26499	RB	denotes	too
T7112	26500-26501	-LRB-	denotes	[
T7113	26501-26503	CD	denotes	22
T7114	26503-26504	-RRB-	denotes	]
T7115	26504-26505	.	denotes	.
T7116	26505-26597	sentence	denotes	Also the genetic background in common laboratory and transgenic mice affects the phenotype.
T7117	26506-26510	RB	denotes	Also
T7118	26575-26582	VBZ	denotes	affects
T7119	26511-26514	DT	denotes	the
T7120	26523-26533	NN	denotes	background
T7121	26515-26522	JJ	denotes	genetic
T7122	26534-26536	IN	denotes	in
T7123	26537-26543	JJ	denotes	common
T7124	26570-26574	NNS	denotes	mice
T7125	26544-26554	NN	denotes	laboratory
T7126	26555-26558	CC	denotes	and
T7127	26559-26569	JJ	denotes	transgenic
T7128	26583-26586	DT	denotes	the
T7129	26587-26596	NN	denotes	phenotype
T7130	26596-26597	.	denotes	.
T7131	26597-26704	sentence	denotes	A change from one strain to another may protect mice from effects of the primarily induced genetic defect.
T7132	26598-26599	DT	denotes	A
T7133	26600-26606	NN	denotes	change
T7134	26638-26645	VB	denotes	protect
T7135	26607-26611	IN	denotes	from
T7136	26612-26615	CD	denotes	one
T7137	26616-26622	NN	denotes	strain
T7138	26623-26625	IN	denotes	to
T7139	26626-26633	DT	denotes	another
T7140	26634-26637	MD	denotes	may
T7141	26646-26650	NNS	denotes	mice
T7142	26651-26655	IN	denotes	from
T7143	26656-26663	NNS	denotes	effects
T7144	26664-26666	IN	denotes	of
T7145	26667-26670	DT	denotes	the
T7146	26697-26703	NN	denotes	defect
T7147	26671-26680	RB	denotes	primarily
T7148	26681-26688	VBN	denotes	induced
T7149	26689-26696	JJ	denotes	genetic
T7150	26703-26704	.	denotes	.
T7151	26704-26864	sentence	denotes	For example, BALB/c mice have a significantly increased velocity of platelet aggregation as compared to 129Sv mice, which were used throughout this study [23].
T7152	26705-26708	IN	denotes	For
T7153	26730-26734	VBP	denotes	have
T7154	26709-26716	NN	denotes	example
T7155	26716-26718	,	denotes	,
T7156	26718-26722	NN	denotes	BALB
T7157	26723-26724	NN	denotes	c
T7158	26722-26723	HYPH	denotes	/
T7159	26725-26729	NNS	denotes	mice
T7160	26735-26736	DT	denotes	a
T7161	26761-26769	NN	denotes	velocity
T7162	26737-26750	RB	denotes	significantly
T7163	26751-26760	VBN	denotes	increased
T7164	26770-26772	IN	denotes	of
T7165	26773-26781	NN	denotes	platelet
T7166	26782-26793	NN	denotes	aggregation
T7167	26794-26796	IN	denotes	as
T7168	26797-26805	VBN	denotes	compared
T7169	26806-26808	IN	denotes	to
T7170	26809-26814	NN	denotes	129Sv
T7171	26815-26819	NNS	denotes	mice
T7172	26819-26821	,	denotes	,
T7173	26821-26826	WDT	denotes	which
T7174	26832-26836	VBN	denotes	used
T7175	26827-26831	VBD	denotes	were
T7176	26837-26847	IN	denotes	throughout
T7177	26848-26852	DT	denotes	this
T7178	26853-26858	NN	denotes	study
T7179	26859-26860	-LRB-	denotes	[
T7180	26860-26862	CD	denotes	23
T7181	26862-26863	-RRB-	denotes	]
T7182	26863-26864	.	denotes	.
T7273	26866-26870	NN	denotes	Self
T7274	26871-26878	VBG	denotes	forming
T7275	26897-26906	NNS	denotes	gradients
T7276	26879-26888	NN	denotes	iodixanol
T7277	26889-26896	NN	denotes	density
T7278	26907-26909	IN	denotes	of
T7279	26910-26915	JJ	denotes	human
T7280	26926-26931	NNS	denotes	cells
T7281	26916-26919	JJ	denotes	red
T7282	26920-26925	NN	denotes	blood
T7283	26931-27007	sentence	denotes	The subcellular distribution of annexin A7 was addressed according to [24].
T7284	26932-26935	DT	denotes	The
T7285	26948-26960	NN	denotes	distribution
T7286	26936-26947	JJ	denotes	subcellular
T7287	26979-26988	VBN	denotes	addressed
T7288	26961-26963	IN	denotes	of
T7289	26964-26971	NN	denotes	annexin
T7290	26972-26974	NN	denotes	A7
T7291	26975-26978	VBD	denotes	was
T7292	26989-26998	VBG	denotes	according
T7293	26999-27001	IN	denotes	to
T7294	27002-27003	-LRB-	denotes	[
T7295	27003-27005	CD	denotes	24
T7296	27005-27006	-RRB-	denotes	]
T7297	27006-27007	.	denotes	.
T7298	27007-27313	sentence	denotes	Red blood cells were centrifuged and washed in isotonic buffered salt solution, collected in ice cold lysis buffer (20 mM Hepes, pH 7.4, 200 μM CaCl2, 0.25 M sucrose, and proteinase inhibitors (Roche)), homogenized by a loosely fitting dounce homogenizer and additional passages through a 22 gauge needle.
T7299	27008-27011	JJ	denotes	Red
T7300	27018-27023	NNS	denotes	cells
T7301	27012-27017	NN	denotes	blood
T7302	27029-27040	VBN	denotes	centrifuged
T7303	27024-27028	VBD	denotes	were
T7304	27041-27044	CC	denotes	and
T7305	27045-27051	VBN	denotes	washed
T7306	27052-27054	IN	denotes	in
T7307	27055-27063	JJ	denotes	isotonic
T7308	27078-27086	NN	denotes	solution
T7309	27064-27072	VBN	denotes	buffered
T7310	27073-27077	NN	denotes	salt
T7311	27086-27088	,	denotes	,
T7312	27088-27097	VBN	denotes	collected
T7313	27098-27100	IN	denotes	in
T7314	27101-27104	NN	denotes	ice
T7315	27105-27109	JJ	denotes	cold
T7316	27116-27122	NN	denotes	buffer
T7317	27110-27115	NN	denotes	lysis
T7318	27123-27124	-LRB-	denotes	(
T7319	27130-27135	NN	denotes	Hepes
T7320	27124-27126	CD	denotes	20
T7321	27127-27129	NN	denotes	mM
T7322	27135-27137	,	denotes	,
T7323	27137-27139	NN	denotes	pH
T7324	27140-27143	CD	denotes	7.4
T7325	27143-27145	,	denotes	,
T7326	27145-27148	CD	denotes	200
T7327	27149-27151	NN	denotes	μM
T7328	27152-27157	NN	denotes	CaCl2
T7329	27157-27159	,	denotes	,
T7330	27159-27163	CD	denotes	0.25
T7331	27164-27165	NN	denotes	M
T7332	27166-27173	NN	denotes	sucrose
T7333	27173-27175	,	denotes	,
T7334	27175-27178	CC	denotes	and
T7335	27179-27189	NN	denotes	proteinase
T7336	27190-27200	NNS	denotes	inhibitors
T7337	27201-27202	-LRB-	denotes	(
T7338	27202-27207	NNP	denotes	Roche
T7339	27207-27208	-RRB-	denotes	)
T7340	27208-27209	-RRB-	denotes	)
T7341	27209-27211	,	denotes	,
T7342	27211-27222	VBN	denotes	homogenized
T7343	27223-27225	IN	denotes	by
T7344	27226-27227	DT	denotes	a
T7345	27251-27262	NN	denotes	homogenizer
T7346	27228-27235	RB	denotes	loosely
T7347	27236-27243	JJ	denotes	fitting
T7348	27244-27250	NN	denotes	dounce
T7349	27263-27266	CC	denotes	and
T7350	27267-27277	JJ	denotes	additional
T7351	27278-27286	NNS	denotes	passages
T7352	27287-27294	IN	denotes	through
T7353	27295-27296	DT	denotes	a
T7354	27306-27312	NN	denotes	needle
T7355	27297-27299	CD	denotes	22
T7356	27300-27305	NN	denotes	gauge
T7357	27312-27313	.	denotes	.
T7358	27313-27473	sentence	denotes	A 50 % iodixanol solution was established by mixing Optiprep solution (60 % iodixanol; Sigma) with buffer (120 mM Hepes, pH 7.4, 1.2 mM CaCl2, 0.25 M sucrose).
T7359	27314-27315	DT	denotes	A
T7360	27331-27339	NN	denotes	solution
T7361	27316-27318	CD	denotes	50
T7362	27319-27320	NN	denotes	%
T7363	27321-27330	NN	denotes	iodixanol
T7364	27344-27355	VBN	denotes	established
T7365	27340-27343	VBD	denotes	was
T7366	27356-27358	IN	denotes	by
T7367	27359-27365	VBG	denotes	mixing
T7368	27366-27374	NN	denotes	Optiprep
T7369	27375-27383	NN	denotes	solution
T7370	27384-27385	-LRB-	denotes	(
T7371	27401-27406	NN	denotes	Sigma
T7372	27385-27387	CD	denotes	60
T7373	27388-27389	NN	denotes	%
T7374	27390-27399	NN	denotes	iodixanol
T7375	27399-27400	:	denotes	;
T7376	27406-27407	-RRB-	denotes	)
T7377	27408-27412	IN	denotes	with
T7378	27413-27419	NN	denotes	buffer
T7379	27420-27421	-LRB-	denotes	(
T7380	27464-27471	NN	denotes	sucrose
T7381	27421-27424	CD	denotes	120
T7382	27425-27427	NN	denotes	mM
T7383	27428-27433	NN	denotes	Hepes
T7384	27433-27435	,	denotes	,
T7385	27435-27437	NN	denotes	pH
T7386	27438-27441	CD	denotes	7.4
T7387	27441-27443	,	denotes	,
T7388	27443-27446	CD	denotes	1.2
T7389	27447-27449	NN	denotes	mM
T7390	27450-27455	NN	denotes	CaCl2
T7391	27455-27457	,	denotes	,
T7392	27457-27461	CD	denotes	0.25
T7393	27462-27463	NN	denotes	M
T7394	27471-27472	-RRB-	denotes	)
T7395	27472-27473	.	denotes	.
T7396	27473-27640	sentence	denotes	Seven parts of this 50 % iodixanol solution were mixed with thirteen parts of the red blood cell solution, generating a gradient solution containing 17.5 % iodixanol.
T7397	27474-27479	CD	denotes	Seven
T7398	27480-27485	NNS	denotes	parts
T7399	27523-27528	VBN	denotes	mixed
T7400	27486-27488	IN	denotes	of
T7401	27489-27493	DT	denotes	this
T7402	27509-27517	NN	denotes	solution
T7403	27494-27496	CD	denotes	50
T7404	27497-27498	NN	denotes	%
T7405	27499-27508	NN	denotes	iodixanol
T7406	27518-27522	VBD	denotes	were
T7407	27529-27533	IN	denotes	with
T7408	27534-27542	CD	denotes	thirteen
T7409	27543-27548	NNS	denotes	parts
T7410	27549-27551	IN	denotes	of
T7411	27552-27555	DT	denotes	the
T7412	27571-27579	NN	denotes	solution
T7413	27556-27559	JJ	denotes	red
T7414	27566-27570	NN	denotes	cell
T7415	27560-27565	NN	denotes	blood
T7416	27579-27581	,	denotes	,
T7417	27581-27591	VBG	denotes	generating
T7418	27592-27593	DT	denotes	a
T7419	27603-27611	NN	denotes	solution
T7420	27594-27602	NN	denotes	gradient
T7421	27612-27622	VBG	denotes	containing
T7422	27623-27627	CD	denotes	17.5
T7423	27628-27629	NN	denotes	%
T7424	27630-27639	NN	denotes	iodixanol
T7425	27639-27640	.	denotes	.
T7426	27640-27907	sentence	denotes	The mixture was filled into a centrifuge tube underlayed by cushions of 30 % and 35 % iodixanol and centrifuged for 3 hours at 270,000 × g in a SW41 Ti swing out rotor (Beckman) to achieve a nearly linear density gradient (approximately 1.06 g/ml to 1.20 g/ml) [24].
T7427	27641-27644	DT	denotes	The
T7428	27645-27652	NN	denotes	mixture
T7429	27657-27663	VBN	denotes	filled
T7430	27653-27656	VBD	denotes	was
T7431	27664-27668	IN	denotes	into
T7432	27669-27670	DT	denotes	a
T7433	27682-27686	NN	denotes	tube
T7434	27671-27681	JJ	denotes	centrifuge
T7435	27687-27697	VBN	denotes	underlayed
T7436	27698-27700	IN	denotes	by
T7437	27701-27709	NNS	denotes	cushions
T7438	27710-27712	IN	denotes	of
T7439	27713-27715	CD	denotes	30
T7440	27716-27717	NN	denotes	%
T7441	27727-27736	NN	denotes	iodixanol
T7442	27718-27721	CC	denotes	and
T7443	27722-27724	CD	denotes	35
T7444	27725-27726	NN	denotes	%
T7445	27737-27740	CC	denotes	and
T7446	27741-27752	VBN	denotes	centrifuged
T7447	27753-27756	IN	denotes	for
T7448	27757-27758	CD	denotes	3
T7449	27759-27764	NNS	denotes	hours
T7450	27765-27767	IN	denotes	at
T7451	27768-27775	CD	denotes	270,000
T7452	27778-27779	NN	denotes	g
T7453	27776-27777	SYM	denotes	×
T7454	27780-27782	IN	denotes	in
T7455	27783-27784	DT	denotes	a
T7456	27803-27808	NN	denotes	rotor
T7457	27785-27789	NN	denotes	SW41
T7458	27790-27792	NNP	denotes	Ti
T7459	27793-27798	NN	denotes	swing
T7460	27799-27802	NN	denotes	out
T7461	27809-27810	-LRB-	denotes	(
T7462	27810-27817	NN	denotes	Beckman
T7463	27817-27818	-RRB-	denotes	)
T7464	27819-27821	TO	denotes	to
T7465	27822-27829	VB	denotes	achieve
T7466	27830-27831	DT	denotes	a
T7467	27854-27862	NN	denotes	gradient
T7468	27832-27838	RB	denotes	nearly
T7469	27839-27845	JJ	denotes	linear
T7470	27846-27853	NN	denotes	density
T7471	27863-27864	-LRB-	denotes	(
T7472	27883-27884	NNS	denotes	g
T7473	27864-27877	RB	denotes	approximately
T7474	27878-27882	CD	denotes	1.06
T7475	27884-27885	SYM	denotes	/
T7476	27885-27887	NN	denotes	ml
T7477	27888-27890	IN	denotes	to
T7478	27891-27895	CD	denotes	1.20
T7479	27896-27897	NNS	denotes	g
T7480	27897-27898	SYM	denotes	/
T7481	27898-27900	NN	denotes	ml
T7482	27900-27901	-RRB-	denotes	)
T7483	27902-27903	-LRB-	denotes	[
T7484	27903-27905	CD	denotes	24
T7485	27905-27906	-RRB-	denotes	]
T7486	27906-27907	.	denotes	.
T7487	27907-28071	sentence	denotes	Fractions of 0.6 ml were collected from the top of the gradient by a 1 ml syringe without using a needle and immediately frozen in liquid nitrogen for further use.
T7488	27908-27917	NNS	denotes	Fractions
T7489	27933-27942	VBN	denotes	collected
T7490	27918-27920	IN	denotes	of
T7491	27921-27924	CD	denotes	0.6
T7492	27925-27927	NN	denotes	ml
T7493	27928-27932	VBD	denotes	were
T7494	27943-27947	IN	denotes	from
T7495	27948-27951	DT	denotes	the
T7496	27952-27955	NN	denotes	top
T7497	27956-27958	IN	denotes	of
T7498	27959-27962	DT	denotes	the
T7499	27963-27971	NN	denotes	gradient
T7500	27972-27974	IN	denotes	by
T7501	27975-27976	DT	denotes	a
T7502	27982-27989	NN	denotes	syringe
T7503	27977-27978	CD	denotes	1
T7504	27979-27981	NN	denotes	ml
T7505	27990-27997	IN	denotes	without
T7506	27998-28003	VBG	denotes	using
T7507	28004-28005	DT	denotes	a
T7508	28006-28012	NN	denotes	needle
T7509	28013-28016	CC	denotes	and
T7510	28017-28028	RB	denotes	immediately
T7511	28029-28035	VBN	denotes	frozen
T7512	28036-28038	IN	denotes	in
T7513	28039-28045	JJ	denotes	liquid
T7514	28046-28054	NN	denotes	nitrogen
T7515	28055-28058	IN	denotes	for
T7516	28059-28066	JJ	denotes	further
T7517	28067-28070	NN	denotes	use
T7518	28070-28071	.	denotes	.
T7632	28073-28083	NN	denotes	Exovesicle
T7633	28084-28094	NN	denotes	generation
T7634	28095-28099	IN	denotes	from
T7635	28100-28105	JJ	denotes	human
T7636	28127-28132	NNS	denotes	cells
T7637	28106-28109	CC	denotes	and
T7638	28110-28116	JJ	denotes	murine
T7639	28117-28120	JJ	denotes	red
T7640	28121-28126	NN	denotes	blood
T7641	28132-28202	sentence	denotes	Red blood cells naturally can form hemoglobin containing exovesicles.
T7642	28133-28136	JJ	denotes	Red
T7643	28143-28148	NNS	denotes	cells
T7644	28137-28142	NN	denotes	blood
T7645	28163-28167	VB	denotes	form
T7646	28149-28158	RB	denotes	naturally
T7647	28159-28162	MD	denotes	can
T7648	28168-28178	NN	denotes	hemoglobin
T7649	28179-28189	VBG	denotes	containing
T7650	28190-28201	NNS	denotes	exovesicles
T7651	28201-28202	.	denotes	.
T7652	28202-28252	sentence	denotes	In vitro these vesicle formation is Ca2+ induced.
T7653	28203-28205	FW	denotes	In
T7654	28206-28211	FW	denotes	vitro
T7655	28236-28238	VBZ	denotes	is
T7656	28212-28217	DT	denotes	these
T7657	28226-28235	NN	denotes	formation
T7658	28218-28225	NN	denotes	vesicle
T7659	28239-28243	NN	denotes	Ca2+
T7660	28244-28251	VBN	denotes	induced
T7661	28251-28252	.	denotes	.
T7662	28252-28366	sentence	denotes	Freshly collected lithium-heparin anticoagulated blood samples were centrifuged for 5 minutes at 400 × g and 4°C.
T7663	28253-28260	RB	denotes	Freshly
T7664	28261-28270	VBN	denotes	collected
T7665	28308-28315	NNS	denotes	samples
T7666	28271-28278	NN	denotes	lithium
T7667	28279-28286	NN	denotes	heparin
T7668	28278-28279	HYPH	denotes	-
T7669	28287-28301	VBN	denotes	anticoagulated
T7670	28302-28307	NN	denotes	blood
T7671	28321-28332	VBN	denotes	centrifuged
T7672	28316-28320	VBD	denotes	were
T7673	28333-28336	IN	denotes	for
T7674	28337-28338	CD	denotes	5
T7675	28339-28346	NNS	denotes	minutes
T7676	28347-28349	IN	denotes	at
T7677	28350-28353	CD	denotes	400
T7678	28356-28357	NN	denotes	g
T7679	28354-28355	SYM	denotes	×
T7680	28358-28361	CC	denotes	and
T7681	28362-28363	CD	denotes	4
T7682	28363-28365	NN	denotes	°C
T7683	28365-28366	.	denotes	.
T7684	28366-28466	sentence	denotes	The erythrocytes were washed five times with 20 mM Hepes, pH 7.5, and 150 mM NaCl (washing buffer).
T7685	28367-28370	DT	denotes	The
T7686	28371-28383	NNS	denotes	erythrocytes
T7687	28389-28395	VBN	denotes	washed
T7688	28384-28388	VBD	denotes	were
T7689	28396-28400	CD	denotes	five
T7690	28401-28406	NNS	denotes	times
T7691	28407-28411	IN	denotes	with
T7692	28412-28414	CD	denotes	20
T7693	28415-28417	NN	denotes	mM
T7694	28418-28423	NN	denotes	Hepes
T7695	28423-28425	,	denotes	,
T7696	28425-28427	NN	denotes	pH
T7697	28428-28431	CD	denotes	7.5
T7698	28431-28433	,	denotes	,
T7699	28433-28436	CC	denotes	and
T7700	28437-28440	CD	denotes	150
T7701	28441-28443	NN	denotes	mM
T7702	28444-28448	NN	denotes	NaCl
T7703	28449-28450	-LRB-	denotes	(
T7704	28458-28464	NN	denotes	buffer
T7705	28450-28457	VBG	denotes	washing
T7706	28464-28465	-RRB-	denotes	)
T7707	28465-28466	.	denotes	.
T7708	28466-28679	sentence	denotes	A volume of 500 μl washed red blood cells were combined with 3 ml of vesiculation buffer (20 mM Hepes, pH 7.5, 150 mM NaCl, 1 mM CaCl2 adjusted to 5 μM Ca2+ ionophore A23187) and incubated for 30 minutes at 37°C.
T7709	28467-28468	DT	denotes	A
T7710	28469-28475	NN	denotes	volume
T7711	28514-28522	VBN	denotes	combined
T7712	28476-28478	IN	denotes	of
T7713	28479-28482	CD	denotes	500
T7714	28483-28485	NN	denotes	μl
T7715	28503-28508	NNS	denotes	cells
T7716	28486-28492	VBN	denotes	washed
T7717	28493-28496	JJ	denotes	red
T7718	28497-28502	NN	denotes	blood
T7719	28509-28513	VBD	denotes	were
T7720	28523-28527	IN	denotes	with
T7721	28528-28529	CD	denotes	3
T7722	28530-28532	NN	denotes	ml
T7723	28533-28535	IN	denotes	of
T7724	28536-28548	NN	denotes	vesiculation
T7725	28549-28555	NN	denotes	buffer
T7726	28556-28557	-LRB-	denotes	(
T7727	28596-28601	NN	denotes	CaCl2
T7728	28557-28559	CD	denotes	20
T7729	28560-28562	NN	denotes	mM
T7730	28563-28568	NN	denotes	Hepes
T7731	28568-28570	,	denotes	,
T7732	28570-28572	NN	denotes	pH
T7733	28573-28576	CD	denotes	7.5
T7734	28576-28578	,	denotes	,
T7735	28578-28581	CD	denotes	150
T7736	28582-28584	NN	denotes	mM
T7737	28585-28589	NN	denotes	NaCl
T7738	28589-28591	,	denotes	,
T7739	28591-28592	CD	denotes	1
T7740	28593-28595	NN	denotes	mM
T7741	28602-28610	VBN	denotes	adjusted
T7742	28611-28613	IN	denotes	to
T7743	28614-28615	CD	denotes	5
T7744	28616-28618	NN	denotes	μM
T7745	28634-28640	NN	denotes	A23187
T7746	28619-28623	NN	denotes	Ca2+
T7747	28624-28633	NN	denotes	ionophore
T7748	28640-28641	-RRB-	denotes	)
T7749	28642-28645	CC	denotes	and
T7750	28646-28655	VBN	denotes	incubated
T7751	28656-28659	IN	denotes	for
T7752	28660-28662	CD	denotes	30
T7753	28663-28670	NNS	denotes	minutes
T7754	28671-28673	IN	denotes	at
T7755	28674-28676	CD	denotes	37
T7756	28676-28678	NNS	denotes	°C
T7757	28678-28679	.	denotes	.
T7758	28679-28810	sentence	denotes	After incubation EDTA was added to the solution to a final concentration of 5 mM and centrifuged for 5 minutes at 400 × g and 4°C.
T7759	28680-28685	IN	denotes	After
T7760	28706-28711	VBN	denotes	added
T7761	28686-28696	NN	denotes	incubation
T7762	28697-28701	NN	denotes	EDTA
T7763	28702-28705	VBD	denotes	was
T7764	28712-28714	IN	denotes	to
T7765	28715-28718	DT	denotes	the
T7766	28719-28727	NN	denotes	solution
T7767	28728-28730	IN	denotes	to
T7768	28731-28732	DT	denotes	a
T7769	28739-28752	NN	denotes	concentration
T7770	28733-28738	JJ	denotes	final
T7771	28753-28755	IN	denotes	of
T7772	28756-28757	CD	denotes	5
T7773	28758-28760	NN	denotes	mM
T7774	28761-28764	CC	denotes	and
T7775	28765-28776	VBN	denotes	centrifuged
T7776	28777-28780	IN	denotes	for
T7777	28781-28782	CD	denotes	5
T7778	28783-28790	NNS	denotes	minutes
T7779	28791-28793	IN	denotes	at
T7780	28794-28797	CD	denotes	400
T7781	28800-28801	NN	denotes	g
T7782	28798-28799	SYM	denotes	×
T7783	28802-28805	CC	denotes	and
T7784	28806-28807	CD	denotes	4
T7785	28807-28809	NNS	denotes	°C
T7786	28809-28810	.	denotes	.
T7787	28810-28894	sentence	denotes	The supernatant was collected and centrifuged for 20 minutes at 15,000 × g and 4°C.
T7788	28811-28814	DT	denotes	The
T7789	28815-28826	NN	denotes	supernatant
T7790	28831-28840	VBN	denotes	collected
T7791	28827-28830	VBD	denotes	was
T7792	28841-28844	CC	denotes	and
T7793	28845-28856	VBN	denotes	centrifuged
T7794	28857-28860	IN	denotes	for
T7795	28861-28863	CD	denotes	20
T7796	28864-28871	NNS	denotes	minutes
T7797	28872-28874	IN	denotes	at
T7798	28875-28881	CD	denotes	15,000
T7799	28884-28885	NN	denotes	g
T7800	28882-28883	SYM	denotes	×
T7801	28886-28889	CC	denotes	and
T7802	28890-28891	CD	denotes	4
T7803	28891-28893	NNS	denotes	°C
T7804	28893-28894	.	denotes	.
T7805	28894-29051	sentence	denotes	The resulting pellet was resuspended in washing buffer and centrifuged at 400 × g again to collect a supernatant enriched with red blood cell microvesicles.
T7806	28895-28898	DT	denotes	The
T7807	28909-28915	NN	denotes	pellet
T7808	28899-28908	VBG	denotes	resulting
T7809	28920-28931	VBN	denotes	resuspended
T7810	28916-28919	VBD	denotes	was
T7811	28932-28934	IN	denotes	in
T7812	28935-28942	VBG	denotes	washing
T7813	28943-28949	NN	denotes	buffer
T7814	28950-28953	CC	denotes	and
T7815	28954-28965	VBN	denotes	centrifuged
T7816	28966-28968	IN	denotes	at
T7817	28969-28972	CD	denotes	400
T7818	28975-28976	NN	denotes	g
T7819	28973-28974	SYM	denotes	×
T7820	28977-28982	RB	denotes	again
T7821	28983-28985	TO	denotes	to
T7822	28986-28993	VB	denotes	collect
T7823	28994-28995	DT	denotes	a
T7824	28996-29007	NN	denotes	supernatant
T7825	29008-29016	VBN	denotes	enriched
T7826	29017-29021	IN	denotes	with
T7827	29022-29025	JJ	denotes	red
T7828	29032-29036	NN	denotes	cell
T7829	29026-29031	NN	denotes	blood
T7830	29037-29050	NNS	denotes	microvesicles
T7831	29050-29051	.	denotes	.
T7832	29051-29153	sentence	denotes	The supernatant of the 15,000 × g step was further centrifuged for 60 minutes at 100,000 × g and 4°C.
T7833	29052-29055	DT	denotes	The
T7834	29056-29067	NN	denotes	supernatant
T7835	29103-29114	VBN	denotes	centrifuged
T7836	29068-29070	IN	denotes	of
T7837	29071-29074	DT	denotes	the
T7838	29086-29090	NN	denotes	step
T7839	29075-29081	CD	denotes	15,000
T7840	29084-29085	NN	denotes	g
T7841	29082-29083	SYM	denotes	×
T7842	29091-29094	VBD	denotes	was
T7843	29095-29102	RBR	denotes	further
T7844	29115-29118	IN	denotes	for
T7845	29119-29121	CD	denotes	60
T7846	29122-29129	NNS	denotes	minutes
T7847	29130-29132	IN	denotes	at
T7848	29133-29140	CD	denotes	100,000
T7849	29143-29144	NN	denotes	g
T7850	29141-29142	SYM	denotes	×
T7851	29145-29148	CC	denotes	and
T7852	29149-29150	CD	denotes	4
T7853	29150-29152	NNS	denotes	°C
T7854	29152-29153	.	denotes	.
T7855	29153-29323	sentence	denotes	The final pellet of this step was resuspended in washing buffer and centrifuged at 15,000 × g again to purify a supernatant enriched in nanovesicles according to [7,20].
T7856	29154-29157	DT	denotes	The
T7857	29164-29170	NN	denotes	pellet
T7858	29158-29163	JJ	denotes	final
T7859	29188-29199	VBN	denotes	resuspended
T7860	29171-29173	IN	denotes	of
T7861	29174-29178	DT	denotes	this
T7862	29179-29183	NN	denotes	step
T7863	29184-29187	VBD	denotes	was
T7864	29200-29202	IN	denotes	in
T7865	29203-29210	VBG	denotes	washing
T7866	29211-29217	NN	denotes	buffer
T7867	29218-29221	CC	denotes	and
T7868	29222-29233	VBN	denotes	centrifuged
T7869	29234-29236	IN	denotes	at
T7870	29237-29243	CD	denotes	15,000
T7871	29246-29247	NN	denotes	g
T7872	29244-29245	SYM	denotes	×
T7873	29248-29253	RB	denotes	again
T7874	29254-29256	TO	denotes	to
T7875	29257-29263	VB	denotes	purify
T7876	29264-29265	DT	denotes	a
T7877	29266-29277	NN	denotes	supernatant
T7878	29278-29286	VBN	denotes	enriched
T7879	29287-29289	IN	denotes	in
T7880	29290-29302	NNS	denotes	nanovesicles
T7881	29303-29312	VBG	denotes	according
T7882	29313-29315	IN	denotes	to
T7883	29316-29317	-LRB-	denotes	[
T7884	29317-29318	CD	denotes	7
T7885	29319-29321	CD	denotes	20
T7886	29318-29319	,	denotes	,
T7887	29321-29322	-RRB-	denotes	]
T7888	29322-29323	.	denotes	.
T7889	29323-29416	sentence	denotes	The vesicles were assayed for acetylcholine esterase activity and used for further analysis.
T7890	29324-29327	DT	denotes	The
T7891	29328-29336	NNS	denotes	vesicles
T7892	29342-29349	VBN	denotes	assayed
T7893	29337-29341	VBD	denotes	were
T7894	29350-29353	IN	denotes	for
T7895	29354-29367	NN	denotes	acetylcholine
T7896	29368-29376	NN	denotes	esterase
T7897	29377-29385	NN	denotes	activity
T7898	29386-29389	CC	denotes	and
T7899	29390-29394	VBN	denotes	used
T7900	29395-29398	IN	denotes	for
T7901	29399-29406	JJ	denotes	further
T7902	29407-29415	NN	denotes	analysis
T7903	29415-29416	.	denotes	.
T7951	29418-29431	NN	denotes	Acetylcholine
T7952	29432-29440	NN	denotes	esterase
T7953	29441-29446	NN	denotes	assay
T7954	29446-29631	sentence	denotes	A 30 μl sample of red blood cell vesicles was mixed with an equal volume of buffer (20 mM Hepes, pH 7.6, 150 mM NaCl, 0.5 % Triton X-100), vortexed and incubated for 5 minutes at 37°C.
T7955	29447-29448	DT	denotes	A
T7956	29455-29461	NN	denotes	sample
T7957	29449-29451	CD	denotes	30
T7958	29452-29454	NN	denotes	μl
T7959	29493-29498	VBN	denotes	mixed
T7960	29462-29464	IN	denotes	of
T7961	29465-29468	JJ	denotes	red
T7962	29475-29479	NN	denotes	cell
T7963	29469-29474	NN	denotes	blood
T7964	29480-29488	NNS	denotes	vesicles
T7965	29489-29492	VBD	denotes	was
T7966	29499-29503	IN	denotes	with
T7967	29504-29506	DT	denotes	an
T7968	29513-29519	NN	denotes	volume
T7969	29507-29512	JJ	denotes	equal
T7970	29520-29522	IN	denotes	of
T7971	29523-29529	NN	denotes	buffer
T7972	29530-29531	-LRB-	denotes	(
T7973	29578-29579	NN	denotes	X
T7974	29531-29533	CD	denotes	20
T7975	29534-29536	NN	denotes	mM
T7976	29537-29542	NN	denotes	Hepes
T7977	29542-29544	,	denotes	,
T7978	29544-29546	NN	denotes	pH
T7979	29547-29550	CD	denotes	7.6
T7980	29550-29552	,	denotes	,
T7981	29552-29555	CD	denotes	150
T7982	29556-29558	NN	denotes	mM
T7983	29559-29563	NN	denotes	NaCl
T7984	29563-29565	,	denotes	,
T7985	29565-29568	CD	denotes	0.5
T7986	29569-29570	NN	denotes	%
T7987	29571-29577	NN	denotes	Triton
T7988	29579-29580	HYPH	denotes	-
T7989	29580-29583	CD	denotes	100
T7990	29583-29584	-RRB-	denotes	)
T7991	29584-29586	,	denotes	,
T7992	29586-29594	VBN	denotes	vortexed
T7993	29595-29598	CC	denotes	and
T7994	29599-29608	VBN	denotes	incubated
T7995	29609-29612	IN	denotes	for
T7996	29613-29614	CD	denotes	5
T7997	29615-29622	NNS	denotes	minutes
T7998	29623-29625	IN	denotes	at
T7999	29626-29628	CD	denotes	37
T8000	29628-29630	NNS	denotes	°C
T8001	29630-29631	.	denotes	.
T8002	29631-29851	sentence	denotes	Subsequently 640 μl sodium phosphate buffer (100 mM Na2PO4, pH 7.6), 50 μl DTNB (5,5'-dithiobis-(2-nitrobenzoic acid), 10 mM in sodium phosphate buffer), and 50 μl acetylthiocholine chloride (12,5 mM in H2O) were added.
T8003	29632-29644	RB	denotes	Subsequently
T8004	29845-29850	VBN	denotes	added
T8005	29645-29648	CD	denotes	640
T8006	29649-29651	NN	denotes	μl
T8007	29669-29675	NN	denotes	buffer
T8008	29652-29658	NN	denotes	sodium
T8009	29659-29668	NN	denotes	phosphate
T8010	29676-29677	-LRB-	denotes	(
T8011	29684-29690	NN	denotes	Na2PO4
T8012	29677-29680	CD	denotes	100
T8013	29681-29683	NN	denotes	mM
T8014	29690-29692	,	denotes	,
T8015	29692-29694	NN	denotes	pH
T8016	29695-29698	CD	denotes	7.6
T8017	29698-29699	-RRB-	denotes	)
T8018	29699-29701	,	denotes	,
T8019	29701-29703	CD	denotes	50
T8020	29704-29706	NN	denotes	μl
T8021	29707-29711	NN	denotes	DTNB
T8022	29712-29713	-LRB-	denotes	(
T8023	29754-29756	NN	denotes	mM
T8024	29713-29714	CD	denotes	5
T8025	29718-29727	NN	denotes	dithiobis
T8026	29714-29715	,	denotes	,
T8027	29715-29716	CD	denotes	5
T8028	29716-29717	SYM	denotes	'
T8029	29717-29718	HYPH	denotes	-
T8030	29727-29728	HYPH	denotes	-
T8031	29728-29729	-LRB-	denotes	(
T8032	29744-29748	NN	denotes	acid
T8033	29729-29730	CD	denotes	2
T8034	29730-29731	HYPH	denotes	-
T8035	29731-29743	JJ	denotes	nitrobenzoic
T8036	29748-29749	-RRB-	denotes	)
T8037	29749-29751	,	denotes	,
T8038	29751-29753	CD	denotes	10
T8039	29757-29759	IN	denotes	in
T8040	29760-29766	NN	denotes	sodium
T8041	29767-29776	NN	denotes	phosphate
T8042	29777-29783	NN	denotes	buffer
T8043	29783-29784	-RRB-	denotes	)
T8044	29784-29786	,	denotes	,
T8045	29786-29789	CC	denotes	and
T8046	29790-29792	CD	denotes	50
T8047	29793-29795	NN	denotes	μl
T8048	29814-29822	NN	denotes	chloride
T8049	29796-29813	NN	denotes	acetylthiocholine
T8050	29823-29824	-LRB-	denotes	(
T8051	29829-29831	NN	denotes	mM
T8052	29824-29826	CD	denotes	12
T8053	29826-29827	,	denotes	,
T8054	29827-29828	CD	denotes	5
T8055	29832-29834	IN	denotes	in
T8056	29835-29838	NN	denotes	H2O
T8057	29838-29839	-RRB-	denotes	)
T8058	29840-29844	VBD	denotes	were
T8059	29850-29851	.	denotes	.
T8060	29851-29993	sentence	denotes	The reaction took place at room temperature and was measured photometrically at a wavelength of 405 nm according to the Ellmann' method [25].
T8061	29852-29855	DT	denotes	The
T8062	29856-29864	NN	denotes	reaction
T8063	29865-29869	VBD	denotes	took
T8064	29870-29875	NN	denotes	place
T8065	29876-29878	IN	denotes	at
T8066	29879-29883	NN	denotes	room
T8067	29884-29895	NN	denotes	temperature
T8068	29896-29899	CC	denotes	and
T8069	29900-29903	VBD	denotes	was
T8070	29904-29912	VBN	denotes	measured
T8071	29913-29928	RB	denotes	photometrically
T8072	29929-29931	IN	denotes	at
T8073	29932-29933	DT	denotes	a
T8074	29934-29944	NN	denotes	wavelength
T8075	29945-29947	IN	denotes	of
T8076	29948-29951	CD	denotes	405
T8077	29952-29954	NNS	denotes	nm
T8078	29955-29964	VBG	denotes	according
T8079	29965-29967	IN	denotes	to
T8080	29968-29971	DT	denotes	the
T8081	29981-29987	NN	denotes	method
T8082	29972-29979	NNP	denotes	Ellmann
T8083	29979-29980	POS	denotes	'
T8084	29988-29989	-LRB-	denotes	[
T8085	29989-29991	CD	denotes	25
T8086	29991-29992	-RRB-	denotes	]
T8087	29992-29993	.	denotes	.
T8113	29995-30008	NN	denotes	Determination
T8114	30009-30011	IN	denotes	of
T8115	30012-30015	DT	denotes	the
T8116	30024-30034	NN	denotes	resistance
T8117	30016-30023	JJ	denotes	osmotic
T8118	30035-30037	IN	denotes	of
T8119	30038-30041	JJ	denotes	red
T8120	30048-30053	NNS	denotes	cells
T8121	30042-30047	NN	denotes	blood
T8122	30053-30236	sentence	denotes	A Na2HPO4/NaH2PO4 buffered NaCl gradient (pH 7.4) comprised of the following NaCl steps was used for this assay: 0.90%, 0.65%, 0.60%, 0.55%, 0.50%, 0.45%, 0.40%, 0.35%, 0.30%, 0.10%.
T8123	30054-30055	DT	denotes	A
T8124	30086-30094	NN	denotes	gradient
T8125	30056-30063	NN	denotes	Na2HPO4
T8126	30064-30071	NN	denotes	NaH2PO4
T8127	30063-30064	HYPH	denotes	/
T8128	30072-30080	VBN	denotes	buffered
T8129	30081-30085	NN	denotes	NaCl
T8130	30146-30150	VBN	denotes	used
T8131	30095-30096	-LRB-	denotes	(
T8132	30096-30098	NN	denotes	pH
T8133	30099-30102	CD	denotes	7.4
T8134	30102-30103	-RRB-	denotes	)
T8135	30104-30113	VBN	denotes	comprised
T8136	30114-30116	IN	denotes	of
T8137	30117-30120	DT	denotes	the
T8138	30136-30141	NNS	denotes	steps
T8139	30121-30130	VBG	denotes	following
T8140	30131-30135	NN	denotes	NaCl
T8141	30142-30145	VBD	denotes	was
T8142	30151-30154	IN	denotes	for
T8143	30155-30159	DT	denotes	this
T8144	30160-30165	NN	denotes	assay
T8145	30165-30167	:	denotes	:
T8146	30167-30171	CD	denotes	0.90
T8147	30171-30172	NN	denotes	%
T8148	30172-30174	,	denotes	,
T8149	30174-30178	CD	denotes	0.65
T8150	30178-30179	NN	denotes	%
T8151	30179-30181	,	denotes	,
T8152	30181-30185	CD	denotes	0.60
T8153	30185-30186	NN	denotes	%
T8154	30186-30188	,	denotes	,
T8155	30188-30192	CD	denotes	0.55
T8156	30192-30193	NN	denotes	%
T8157	30193-30195	,	denotes	,
T8158	30195-30199	CD	denotes	0.50
T8159	30199-30200	NN	denotes	%
T8160	30200-30202	,	denotes	,
T8161	30202-30206	CD	denotes	0.45
T8162	30206-30207	NN	denotes	%
T8163	30207-30209	,	denotes	,
T8164	30209-30213	CD	denotes	0.40
T8165	30213-30214	NN	denotes	%
T8166	30214-30216	,	denotes	,
T8167	30216-30220	CD	denotes	0.35
T8168	30220-30221	NN	denotes	%
T8169	30221-30223	,	denotes	,
T8170	30223-30227	CD	denotes	0.30
T8171	30227-30228	NN	denotes	%
T8172	30228-30230	,	denotes	,
T8173	30230-30234	CD	denotes	0.10
T8174	30234-30235	NN	denotes	%
T8175	30235-30236	.	denotes	.
T8176	30236-30385	sentence	denotes	For each step 5 ml of the gradient step solution and 50 μl blood sample were carefully inverted four times and incubated for 30 minutes in the dark.
T8177	30237-30240	IN	denotes	For
T8178	30324-30332	VBN	denotes	inverted
T8179	30241-30245	DT	denotes	each
T8180	30246-30250	NN	denotes	step
T8181	30251-30252	CD	denotes	5
T8182	30253-30255	NNS	denotes	ml
T8183	30256-30258	IN	denotes	of
T8184	30259-30262	DT	denotes	the
T8185	30277-30285	NN	denotes	solution
T8186	30263-30271	NN	denotes	gradient
T8187	30272-30276	NN	denotes	step
T8188	30286-30289	CC	denotes	and
T8189	30290-30292	CD	denotes	50
T8190	30293-30295	NN	denotes	μl
T8191	30302-30308	NN	denotes	sample
T8192	30296-30301	NN	denotes	blood
T8193	30309-30313	VBD	denotes	were
T8194	30314-30323	RB	denotes	carefully
T8195	30333-30337	CD	denotes	four
T8196	30338-30343	NNS	denotes	times
T8197	30344-30347	CC	denotes	and
T8198	30348-30357	VBN	denotes	incubated
T8199	30358-30361	IN	denotes	for
T8200	30362-30364	CD	denotes	30
T8201	30365-30372	NNS	denotes	minutes
T8202	30373-30375	IN	denotes	in
T8203	30376-30379	DT	denotes	the
T8204	30380-30384	NN	denotes	dark
T8205	30384-30385	.	denotes	.
T8206	30385-30468	sentence	denotes	Samples were carefully inverted again and centrifuged at 1,500 × g for 10 minutes.
T8207	30386-30393	NNS	denotes	Samples
T8208	30409-30417	VBN	denotes	inverted
T8209	30394-30398	VBD	denotes	were
T8210	30399-30408	RB	denotes	carefully
T8211	30418-30423	RB	denotes	again
T8212	30424-30427	CC	denotes	and
T8213	30428-30439	VBN	denotes	centrifuged
T8214	30440-30442	IN	denotes	at
T8215	30443-30448	CD	denotes	1,500
T8216	30451-30452	NN	denotes	g
T8217	30449-30450	SYM	denotes	×
T8218	30453-30456	IN	denotes	for
T8219	30457-30459	CD	denotes	10
T8220	30460-30467	NNS	denotes	minutes
T8221	30467-30468	.	denotes	.
T8222	30468-30553	sentence	denotes	From 1 ml supernatant of each step the extinction at 546 nm wavelength was measured.
T8223	30469-30473	IN	denotes	From
T8224	30544-30552	VBN	denotes	measured
T8225	30474-30475	CD	denotes	1
T8226	30476-30478	NN	denotes	ml
T8227	30479-30490	NN	denotes	supernatant
T8228	30491-30493	IN	denotes	of
T8229	30494-30498	DT	denotes	each
T8230	30499-30503	NN	denotes	step
T8231	30504-30507	DT	denotes	the
T8232	30508-30518	NN	denotes	extinction
T8233	30519-30521	IN	denotes	at
T8234	30522-30525	CD	denotes	546
T8235	30526-30528	NN	denotes	nm
T8236	30529-30539	NN	denotes	wavelength
T8237	30540-30543	VBD	denotes	was
T8238	30552-30553	.	denotes	.
T8239	30553-30603	sentence	denotes	The experiment was performed at room temperature.
T8240	30554-30557	DT	denotes	The
T8241	30558-30568	NN	denotes	experiment
T8242	30573-30582	VBN	denotes	performed
T8243	30569-30572	VBD	denotes	was
T8244	30583-30585	IN	denotes	at
T8245	30586-30590	NN	denotes	room
T8246	30591-30602	NN	denotes	temperature
T8247	30602-30603	.	denotes	.
T8326	30605-30613	NN	denotes	Platelet
T8327	30614-30625	NN	denotes	aggregation
T8328	30626-30631	NN	denotes	assay
T8329	30631-30712	sentence	denotes	Approximately 500 μl of murine blood were centrifuged at 200 × g for 15 minutes.
T8330	30632-30645	RB	denotes	Approximately
T8331	30646-30649	CD	denotes	500
T8332	30650-30652	NNS	denotes	μl
T8333	30674-30685	VBN	denotes	centrifuged
T8334	30653-30655	IN	denotes	of
T8335	30656-30662	JJ	denotes	murine
T8336	30663-30668	NN	denotes	blood
T8337	30669-30673	VBD	denotes	were
T8338	30686-30688	IN	denotes	at
T8339	30689-30692	CD	denotes	200
T8340	30695-30696	NN	denotes	g
T8341	30693-30694	SYM	denotes	×
T8342	30697-30700	IN	denotes	for
T8343	30701-30703	CD	denotes	15
T8344	30704-30711	NNS	denotes	minutes
T8345	30711-30712	.	denotes	.
T8346	30712-30809	sentence	denotes	The resulting supernatants were transferred to new tubes and used as platelet rich plasma (PRP).
T8347	30713-30716	DT	denotes	The
T8348	30727-30739	NNS	denotes	supernatants
T8349	30717-30726	VBG	denotes	resulting
T8350	30745-30756	VBN	denotes	transferred
T8351	30740-30744	VBD	denotes	were
T8352	30757-30759	IN	denotes	to
T8353	30760-30763	JJ	denotes	new
T8354	30764-30769	NNS	denotes	tubes
T8355	30770-30773	CC	denotes	and
T8356	30774-30778	VBN	denotes	used
T8357	30779-30781	IN	denotes	as
T8358	30782-30790	NN	denotes	platelet
T8359	30791-30795	JJ	denotes	rich
T8360	30796-30802	NN	denotes	plasma
T8361	30803-30804	-LRB-	denotes	(
T8362	30804-30807	NN	denotes	PRP
T8363	30807-30808	-RRB-	denotes	)
T8364	30808-30809	.	denotes	.
T8365	30809-31002	sentence	denotes	The platelet aggregation measurements were done according to the method developed by Born and Cross [26] using an APACT photometer (Labor, Ahrendsburg, FRG) and the APACT software (APACT 1.4).
T8366	30810-30813	DT	denotes	The
T8367	30835-30847	NNS	denotes	measurements
T8368	30814-30822	NN	denotes	platelet
T8369	30823-30834	NN	denotes	aggregation
T8370	30853-30857	VBN	denotes	done
T8371	30848-30852	VBD	denotes	were
T8372	30858-30867	VBG	denotes	according
T8373	30868-30870	IN	denotes	to
T8374	30871-30874	DT	denotes	the
T8375	30875-30881	NN	denotes	method
T8376	30882-30891	VBN	denotes	developed
T8377	30892-30894	IN	denotes	by
T8378	30895-30899	NNP	denotes	Born
T8379	30900-30903	CC	denotes	and
T8380	30904-30909	NNP	denotes	Cross
T8381	30910-30911	-LRB-	denotes	[
T8382	30911-30913	CD	denotes	26
T8383	30913-30914	-RRB-	denotes	]
T8384	30915-30920	VBG	denotes	using
T8385	30921-30923	DT	denotes	an
T8386	30930-30940	NN	denotes	photometer
T8387	30924-30929	NN	denotes	APACT
T8388	30941-30942	-LRB-	denotes	(
T8389	30962-30965	NN	denotes	FRG
T8390	30942-30947	NN	denotes	Labor
T8391	30947-30949	,	denotes	,
T8392	30949-30960	NN	denotes	Ahrendsburg
T8393	30960-30962	,	denotes	,
T8394	30965-30966	-RRB-	denotes	)
T8395	30967-30970	CC	denotes	and
T8396	30971-30974	DT	denotes	the
T8397	30981-30989	NN	denotes	software
T8398	30975-30980	NN	denotes	APACT
T8399	30990-30991	-LRB-	denotes	(
T8400	30991-30996	NN	denotes	APACT
T8401	30997-31000	CD	denotes	1.4
T8402	31000-31001	-RRB-	denotes	)
T8403	31001-31002	.	denotes	.
T8404	31002-31119	sentence	denotes	Subsequently samples of the PRP were adjusted with buffer (5 mM Hepes, 150 mM NaCl, pH 7.3) to 250,000 platelets/μl.
T8405	31003-31015	RB	denotes	Subsequently
T8406	31040-31048	VBN	denotes	adjusted
T8407	31016-31023	NNS	denotes	samples
T8408	31024-31026	IN	denotes	of
T8409	31027-31030	DT	denotes	the
T8410	31031-31034	NN	denotes	PRP
T8411	31035-31039	VBD	denotes	were
T8412	31049-31053	IN	denotes	with
T8413	31054-31060	NN	denotes	buffer
T8414	31061-31062	-LRB-	denotes	(
T8415	31087-31089	NN	denotes	pH
T8416	31062-31063	CD	denotes	5
T8417	31064-31066	NN	denotes	mM
T8418	31067-31072	NN	denotes	Hepes
T8419	31072-31074	,	denotes	,
T8420	31074-31077	CD	denotes	150
T8421	31078-31080	NN	denotes	mM
T8422	31081-31085	NN	denotes	NaCl
T8423	31085-31087	,	denotes	,
T8424	31090-31093	CD	denotes	7.3
T8425	31093-31094	-RRB-	denotes	)
T8426	31095-31097	IN	denotes	to
T8427	31098-31105	CD	denotes	250,000
T8428	31106-31115	NNS	denotes	platelets
T8429	31115-31116	SYM	denotes	/
T8430	31116-31118	NN	denotes	μl
T8431	31118-31119	.	denotes	.
T8432	31119-31244	sentence	denotes	A constant platelet count was used throughout allowing comparisons between wild type and knock out murine and human samples.
T8433	31120-31121	DT	denotes	A
T8434	31140-31145	NN	denotes	count
T8435	31122-31130	JJ	denotes	constant
T8436	31131-31139	NN	denotes	platelet
T8437	31150-31154	VBN	denotes	used
T8438	31146-31149	VBD	denotes	was
T8439	31155-31165	RB	denotes	throughout
T8440	31166-31174	VBG	denotes	allowing
T8441	31175-31186	NNS	denotes	comparisons
T8442	31187-31194	IN	denotes	between
T8443	31195-31199	JJ	denotes	wild
T8444	31200-31204	NN	denotes	type
T8445	31236-31243	NNS	denotes	samples
T8446	31205-31208	CC	denotes	and
T8447	31209-31214	NN	denotes	knock
T8448	31215-31218	NN	denotes	out
T8449	31219-31225	JJ	denotes	murine
T8450	31226-31229	CC	denotes	and
T8451	31230-31235	JJ	denotes	human
T8452	31243-31244	.	denotes	.
T8453	31244-31571	sentence	denotes	250 μl adjusted platelets were prewarmed to 37°C and used in the assay, and the aggregation process was started by adding 25 μl of a prewarmed 16.5 mg/ml ristocetin solution (DiaMed Diagnostica, Bensheim, FRG; concentration in the assay: 1.5 mg/ml), a reagent which worked reliably in our hands with mouse and human platelets.
T8454	31245-31248	CD	denotes	250
T8455	31249-31251	NN	denotes	μl
T8456	31261-31270	NNS	denotes	platelets
T8457	31252-31260	VBN	denotes	adjusted
T8458	31276-31285	VBN	denotes	prewarmed
T8459	31271-31275	VBD	denotes	were
T8460	31286-31288	IN	denotes	to
T8461	31289-31291	CD	denotes	37
T8462	31291-31293	NNS	denotes	°C
T8463	31294-31297	CC	denotes	and
T8464	31298-31302	VBN	denotes	used
T8465	31303-31305	IN	denotes	in
T8466	31306-31309	DT	denotes	the
T8467	31310-31315	NN	denotes	assay
T8468	31315-31317	,	denotes	,
T8469	31317-31320	CC	denotes	and
T8470	31321-31324	DT	denotes	the
T8471	31337-31344	NN	denotes	process
T8472	31325-31336	NN	denotes	aggregation
T8473	31349-31356	VBN	denotes	started
T8474	31345-31348	VBD	denotes	was
T8475	31357-31359	IN	denotes	by
T8476	31360-31366	VBG	denotes	adding
T8477	31367-31369	CD	denotes	25
T8478	31370-31372	NN	denotes	μl
T8479	31373-31375	IN	denotes	of
T8480	31376-31377	DT	denotes	a
T8481	31410-31418	NN	denotes	solution
T8482	31378-31387	JJ	denotes	prewarmed
T8483	31388-31392	CD	denotes	16.5
T8484	31393-31395	NN	denotes	mg
T8485	31395-31396	SYM	denotes	/
T8486	31396-31398	NN	denotes	ml
T8487	31399-31409	NN	denotes	ristocetin
T8488	31419-31420	-LRB-	denotes	(
T8489	31450-31453	NNP	denotes	FRG
T8490	31420-31426	NNP	denotes	DiaMed
T8491	31427-31438	NNP	denotes	Diagnostica
T8492	31438-31440	,	denotes	,
T8493	31440-31448	NNP	denotes	Bensheim
T8494	31448-31450	,	denotes	,
T8495	31453-31454	:	denotes	;
T8496	31455-31468	NN	denotes	concentration
T8497	31487-31489	NNS	denotes	mg
T8498	31469-31471	IN	denotes	in
T8499	31472-31475	DT	denotes	the
T8500	31476-31481	NN	denotes	assay
T8501	31481-31483	:	denotes	:
T8502	31483-31486	CD	denotes	1.5
T8503	31489-31490	SYM	denotes	/
T8504	31490-31492	NN	denotes	ml
T8505	31492-31493	-RRB-	denotes	)
T8506	31493-31495	,	denotes	,
T8507	31495-31496	DT	denotes	a
T8508	31497-31504	NN	denotes	reagent
T8509	31505-31510	WDT	denotes	which
T8510	31511-31517	VBD	denotes	worked
T8511	31518-31526	RB	denotes	reliably
T8512	31527-31529	IN	denotes	in
T8513	31530-31533	PRP$	denotes	our
T8514	31534-31539	NNS	denotes	hands
T8515	31540-31544	IN	denotes	with
T8516	31545-31550	NN	denotes	mouse
T8517	31561-31570	NNS	denotes	platelets
T8518	31551-31554	CC	denotes	and
T8519	31555-31560	JJ	denotes	human
T8520	31570-31571	.	denotes	.
T8521	31571-31620	sentence	denotes	Each murine assay represents a different animal.
T8522	31572-31576	DT	denotes	Each
T8523	31584-31589	NN	denotes	assay
T8524	31577-31583	JJ	denotes	murine
T8525	31590-31600	VBZ	denotes	represents
T8526	31601-31602	DT	denotes	a
T8527	31613-31619	NN	denotes	animal
T8528	31603-31612	JJ	denotes	different
T8529	31619-31620	.	denotes	.
T8530	31620-31712	sentence	denotes	Analyses of human blood samples were performed as described in the manufacturer's protocol.
T8531	31621-31629	NNS	denotes	Analyses
T8532	31658-31667	VBN	denotes	performed
T8533	31630-31632	IN	denotes	of
T8534	31633-31638	JJ	denotes	human
T8535	31645-31652	NNS	denotes	samples
T8536	31639-31644	NN	denotes	blood
T8537	31653-31657	VBD	denotes	were
T8538	31668-31670	IN	denotes	as
T8539	31671-31680	VBN	denotes	described
T8540	31681-31683	IN	denotes	in
T8541	31684-31687	DT	denotes	the
T8542	31688-31700	NN	denotes	manufacturer
T8543	31703-31711	NN	denotes	protocol
T8544	31700-31702	POS	denotes	's
T8545	31711-31712	.	denotes	.
T8546	31712-31805	sentence	denotes	Several repeated measurements were done per human individual to control the reproducibility.
T8547	31713-31720	JJ	denotes	Several
T8548	31730-31742	NNS	denotes	measurements
T8549	31721-31729	JJ	denotes	repeated
T8550	31748-31752	VBN	denotes	done
T8551	31743-31747	VBD	denotes	were
T8552	31753-31756	IN	denotes	per
T8553	31757-31762	JJ	denotes	human
T8554	31763-31773	NN	denotes	individual
T8555	31774-31776	TO	denotes	to
T8556	31777-31784	VB	denotes	control
T8557	31785-31788	DT	denotes	the
T8558	31789-31804	NN	denotes	reproducibility
T8559	31804-31805	.	denotes	.
T8560	31805-32008	sentence	denotes	The acquired aggregation curve data, measured as ascending degree of transmission, were analysed for maximal slope values, while the maximal aggregation amplitude of every single curve was set to 100 %.
T8561	31806-31809	DT	denotes	The
T8562	31837-31841	NNS	denotes	data
T8563	31810-31818	VBN	denotes	acquired
T8564	31819-31830	NN	denotes	aggregation
T8565	31831-31836	NN	denotes	curve
T8566	31894-31902	VBN	denotes	analysed
T8567	31841-31843	,	denotes	,
T8568	31843-31851	VBN	denotes	measured
T8569	31852-31854	IN	denotes	as
T8570	31855-31864	VBG	denotes	ascending
T8571	31865-31871	NN	denotes	degree
T8572	31872-31874	IN	denotes	of
T8573	31875-31887	NN	denotes	transmission
T8574	31887-31889	,	denotes	,
T8575	31889-31893	VBD	denotes	were
T8576	31903-31906	IN	denotes	for
T8577	31907-31914	JJ	denotes	maximal
T8578	31921-31927	NNS	denotes	values
T8579	31915-31920	NN	denotes	slope
T8580	31927-31929	,	denotes	,
T8581	31929-31934	IN	denotes	while
T8582	31995-31998	VBN	denotes	set
T8583	31935-31938	DT	denotes	the
T8584	31959-31968	NN	denotes	amplitude
T8585	31939-31946	JJ	denotes	maximal
T8586	31947-31958	NN	denotes	aggregation
T8587	31969-31971	IN	denotes	of
T8588	31972-31977	DT	denotes	every
T8589	31985-31990	NN	denotes	curve
T8590	31978-31984	JJ	denotes	single
T8591	31991-31994	VBD	denotes	was
T8592	31999-32001	IN	denotes	to
T8593	32002-32005	CD	denotes	100
T8594	32006-32007	NN	denotes	%
T8595	32007-32008	.	denotes	.
T8596	32008-32115	sentence	denotes	In general, all platelet procedures were done at 22°C within four hours after collecting the blood sample.
T8597	32009-32011	IN	denotes	In
T8598	32050-32054	VBN	denotes	done
T8599	32012-32019	JJ	denotes	general
T8600	32019-32021	,	denotes	,
T8601	32021-32024	DT	denotes	all
T8602	32034-32044	NNS	denotes	procedures
T8603	32025-32033	NN	denotes	platelet
T8604	32045-32049	VBD	denotes	were
T8605	32055-32057	IN	denotes	at
T8606	32058-32060	CD	denotes	22
T8607	32060-32062	NNS	denotes	°C
T8608	32063-32069	IN	denotes	within
T8609	32070-32074	CD	denotes	four
T8610	32075-32080	NNS	denotes	hours
T8611	32081-32086	IN	denotes	after
T8612	32087-32097	VBG	denotes	collecting
T8613	32098-32101	DT	denotes	the
T8614	32108-32114	NN	denotes	sample
T8615	32102-32107	NN	denotes	blood
T8616	32114-32115	.	denotes	.
T8735	32117-32130	JJ	denotes	Miscellaneous
T8736	32131-32138	NNS	denotes	methods
T8737	32138-32315	sentence	denotes	For standard haematopoetic measurements and cell counts on murine and human blood samples about 300 μl of blood were analysed with an ADVIA 120 electronic cell counter (Bayer).
T8738	32139-32142	IN	denotes	For
T8739	32256-32264	VBN	denotes	analysed
T8740	32143-32151	JJ	denotes	standard
T8741	32166-32178	NNS	denotes	measurements
T8742	32152-32165	JJ	denotes	haematopoetic
T8743	32179-32182	CC	denotes	and
T8744	32183-32187	NN	denotes	cell
T8745	32188-32194	NNS	denotes	counts
T8746	32195-32197	IN	denotes	on
T8747	32198-32204	JJ	denotes	murine
T8748	32221-32228	NNS	denotes	samples
T8749	32205-32208	CC	denotes	and
T8750	32209-32214	JJ	denotes	human
T8751	32215-32220	NN	denotes	blood
T8752	32229-32234	IN	denotes	about
T8753	32235-32238	CD	denotes	300
T8754	32239-32241	NNS	denotes	μl
T8755	32242-32244	IN	denotes	of
T8756	32245-32250	NN	denotes	blood
T8757	32251-32255	VBD	denotes	were
T8758	32265-32269	IN	denotes	with
T8759	32270-32272	DT	denotes	an
T8760	32299-32306	NN	denotes	counter
T8761	32273-32278	NN	denotes	ADVIA
T8762	32279-32282	CD	denotes	120
T8763	32283-32293	JJ	denotes	electronic
T8764	32294-32298	NN	denotes	cell
T8765	32307-32308	-LRB-	denotes	(
T8766	32308-32313	NN	denotes	Bayer
T8767	32313-32314	-RRB-	denotes	)
T8768	32314-32315	.	denotes	.
T8769	32315-32436	sentence	denotes	With this equipment red blood cells and platelets are "transformed" into spherical bodies without changing their volume.
T8770	32316-32320	IN	denotes	With
T8771	32371-32382	VBN	denotes	transformed
T8772	32321-32325	DT	denotes	this
T8773	32326-32335	NN	denotes	equipment
T8774	32336-32339	JJ	denotes	red
T8775	32346-32351	NNS	denotes	cells
T8776	32340-32345	NN	denotes	blood
T8777	32352-32355	CC	denotes	and
T8778	32356-32365	NNS	denotes	platelets
T8779	32366-32369	VBP	denotes	are
T8780	32370-32371	``	denotes	"
T8781	32382-32383	''	denotes	"
T8782	32384-32388	IN	denotes	into
T8783	32389-32398	JJ	denotes	spherical
T8784	32399-32405	NNS	denotes	bodies
T8785	32406-32413	IN	denotes	without
T8786	32414-32422	VBG	denotes	changing
T8787	32423-32428	PRP$	denotes	their
T8788	32429-32435	NN	denotes	volume
T8789	32435-32436	.	denotes	.
T8790	32436-32554	sentence	denotes	Therefore number and volume of red blood cells and platelets are not calculated values, but directly measured values.
T8791	32437-32446	RB	denotes	Therefore
T8792	32498-32501	VBP	denotes	are
T8793	32447-32453	NN	denotes	number
T8794	32454-32457	CC	denotes	and
T8795	32458-32464	NN	denotes	volume
T8796	32465-32467	IN	denotes	of
T8797	32468-32471	JJ	denotes	red
T8798	32478-32483	NNS	denotes	cells
T8799	32472-32477	NN	denotes	blood
T8800	32484-32487	CC	denotes	and
T8801	32488-32497	NNS	denotes	platelets
T8802	32502-32505	RB	denotes	not
T8803	32506-32516	VBN	denotes	calculated
T8804	32517-32523	NNS	denotes	values
T8805	32523-32525	,	denotes	,
T8806	32525-32528	CC	denotes	but
T8807	32529-32537	RB	denotes	directly
T8808	32538-32546	VBN	denotes	measured
T8809	32547-32553	NNS	denotes	values
T8810	32553-32554	.	denotes	.
T8811	32554-32828	sentence	denotes	The following data were statistically analysed: leucocytes, red blood cells, haemoglobin, haematocrit, mean cellular volume, mean cellular haemoglobin, mean cellular haemoglobin concentration, platelet number, neutrophiles, lymphocytes, monocytes, eosinophiles, basophiles.
T8812	32555-32558	DT	denotes	The
T8813	32569-32573	NNS	denotes	data
T8814	32559-32568	VBG	denotes	following
T8815	32593-32601	VBN	denotes	analysed
T8816	32574-32578	VBD	denotes	were
T8817	32579-32592	RB	denotes	statistically
T8818	32601-32603	:	denotes	:
T8819	32603-32613	NNS	denotes	leucocytes
T8820	32613-32615	,	denotes	,
T8821	32615-32618	JJ	denotes	red
T8822	32625-32630	NNS	denotes	cells
T8823	32619-32624	NN	denotes	blood
T8824	32630-32632	,	denotes	,
T8825	32632-32643	NN	denotes	haemoglobin
T8826	32643-32645	,	denotes	,
T8827	32645-32656	NN	denotes	haematocrit
T8828	32656-32658	,	denotes	,
T8829	32658-32662	JJ	denotes	mean
T8830	32672-32678	NN	denotes	volume
T8831	32663-32671	JJ	denotes	cellular
T8832	32678-32680	,	denotes	,
T8833	32680-32684	JJ	denotes	mean
T8834	32694-32705	NN	denotes	haemoglobin
T8835	32685-32693	JJ	denotes	cellular
T8836	32705-32707	,	denotes	,
T8837	32707-32711	JJ	denotes	mean
T8838	32721-32732	NN	denotes	haemoglobin
T8839	32712-32720	JJ	denotes	cellular
T8840	32733-32746	NN	denotes	concentration
T8841	32746-32748	,	denotes	,
T8842	32748-32756	NN	denotes	platelet
T8843	32757-32763	NN	denotes	number
T8844	32763-32765	,	denotes	,
T8845	32765-32777	NNS	denotes	neutrophiles
T8846	32777-32779	,	denotes	,
T8847	32779-32790	NNS	denotes	lymphocytes
T8848	32790-32792	,	denotes	,
T8849	32792-32801	NNS	denotes	monocytes
T8850	32801-32803	,	denotes	,
T8851	32803-32815	NNS	denotes	eosinophiles
T8852	32815-32817	,	denotes	,
T8853	32817-32827	NNS	denotes	basophiles
T8854	32827-32828	.	denotes	.
T8855	32828-32921	sentence	denotes	Peptide mass fingerprinting was performed on a Bruker Reflex IV MALDI-TOF mass spectrometer.
T8856	32829-32836	NN	denotes	Peptide
T8857	32837-32841	NN	denotes	mass
T8858	32842-32856	NN	denotes	fingerprinting
T8859	32861-32870	VBN	denotes	performed
T8860	32857-32860	VBD	denotes	was
T8861	32871-32873	IN	denotes	on
T8862	32874-32875	DT	denotes	a
T8863	32908-32920	NN	denotes	spectrometer
T8864	32876-32882	NNP	denotes	Bruker
T8865	32883-32889	NNP	denotes	Reflex
T8866	32890-32892	CD	denotes	IV
T8867	32893-32898	NN	denotes	MALDI
T8868	32899-32902	NN	denotes	TOF
T8869	32898-32899	HYPH	denotes	-
T8870	32903-32907	NN	denotes	mass
T8871	32920-32921	.	denotes	.
T8872	32921-33046	sentence	denotes	Recombinant annexin A7 was purified according to [27], F-actin-binding of recombinant annexin A7 was done as described [28].
T8873	32922-32933	JJ	denotes	Recombinant
T8874	32942-32944	NN	denotes	A7
T8875	32934-32941	NN	denotes	annexin
T8876	32949-32957	VBN	denotes	purified
T8877	32945-32948	VBD	denotes	was
T8878	33023-33027	VBN	denotes	done
T8879	32958-32967	VBG	denotes	according
T8880	32968-32970	IN	denotes	to
T8881	32971-32972	-LRB-	denotes	[
T8882	32972-32974	CD	denotes	27
T8883	32974-32975	-RRB-	denotes	]
T8884	32975-32977	,	denotes	,
T8885	32977-32978	NN	denotes	F
T8886	32979-32984	NN	denotes	actin
T8887	32978-32979	HYPH	denotes	-
T8888	32984-32985	HYPH	denotes	-
T8889	32985-32992	VBG	denotes	binding
T8890	32993-32995	IN	denotes	of
T8891	32996-33007	JJ	denotes	recombinant
T8892	33016-33018	NN	denotes	A7
T8893	33008-33015	NN	denotes	annexin
T8894	33019-33022	VBD	denotes	was
T8895	33028-33030	IN	denotes	as
T8896	33031-33040	VBN	denotes	described
T8897	33041-33042	-LRB-	denotes	[
T8898	33042-33044	CD	denotes	28
T8899	33044-33045	-RRB-	denotes	]
T8900	33045-33046	.	denotes	.
T8901	33046-33108	sentence	denotes	SDS-PAGE and western blotting were done as described [29,30].
T8902	33047-33050	NN	denotes	SDS
T8903	33051-33055	NN	denotes	PAGE
T8904	33050-33051	HYPH	denotes	-
T8905	33082-33086	VBN	denotes	done
T8906	33056-33059	CC	denotes	and
T8907	33060-33067	JJ	denotes	western
T8908	33068-33076	NN	denotes	blotting
T8909	33077-33081	VBD	denotes	were
T8910	33087-33089	IN	denotes	as
T8911	33090-33099	VBN	denotes	described
T8912	33100-33101	-LRB-	denotes	[
T8913	33104-33106	CD	denotes	30
T8914	33101-33103	CD	denotes	29
T8915	33103-33104	,	denotes	,
T8916	33106-33107	-RRB-	denotes	]
T8917	33107-33108	.	denotes	.
T8918	33108-33175	sentence	denotes	Detection in immunoblots was with enhanced chemiluminescence [17].
T8919	33109-33118	NN	denotes	Detection
T8920	33134-33137	VBD	denotes	was
T8921	33119-33121	IN	denotes	in
T8922	33122-33133	NNS	denotes	immunoblots
T8923	33138-33142	IN	denotes	with
T8924	33143-33151	VBN	denotes	enhanced
T8925	33152-33169	NN	denotes	chemiluminescence
T8926	33170-33171	-LRB-	denotes	[
T8927	33171-33173	CD	denotes	17
T8928	33173-33174	-RRB-	denotes	]
T8929	33174-33175	.	denotes	.
T8930	33175-33313	sentence	denotes	Antibodies employed were mab 203–217 directed against mouse annexin A7 core domain [5] and a polyclonal rabbit anti-sorcin antibody [31].
T8931	33176-33186	NNS	denotes	Antibodies
T8932	33196-33200	VBD	denotes	were
T8933	33187-33195	VBN	denotes	employed
T8934	33201-33204	NN	denotes	mab
T8935	33205-33208	CD	denotes	203
T8936	33208-33209	SYM	denotes	–
T8937	33209-33212	CD	denotes	217
T8938	33213-33221	VBN	denotes	directed
T8939	33222-33229	IN	denotes	against
T8940	33230-33235	NN	denotes	mouse
T8941	33252-33258	NN	denotes	domain
T8942	33236-33243	NN	denotes	annexin
T8943	33244-33246	NN	denotes	A7
T8944	33247-33251	NN	denotes	core
T8945	33259-33260	-LRB-	denotes	[
T8946	33260-33261	CD	denotes	5
T8947	33261-33262	-RRB-	denotes	]
T8948	33263-33266	CC	denotes	and
T8949	33267-33268	DT	denotes	a
T8950	33299-33307	NN	denotes	antibody
T8951	33269-33279	JJ	denotes	polyclonal
T8952	33280-33286	NN	denotes	rabbit
T8953	33287-33298	JJ	denotes	anti-sorcin
T8954	33308-33309	-LRB-	denotes	[
T8955	33309-33311	CD	denotes	31
T8956	33311-33312	-RRB-	denotes	]
T8957	33312-33313	.	denotes	.
T8958	33313-33630	sentence	denotes	For statistical analyses the following tests were performed: David et al. range test to ensure samples are from a normal distribution, F-test looking for a samples' homoscedascity, Student's T-test to judge if samples of different groups have a different mean value and are parts from different normal distributions.
T8959	33314-33317	IN	denotes	For
T8960	33364-33373	VBN	denotes	performed
T8961	33318-33329	JJ	denotes	statistical
T8962	33330-33338	NNS	denotes	analyses
T8963	33339-33342	DT	denotes	the
T8964	33353-33358	NNS	denotes	tests
T8965	33343-33352	VBG	denotes	following
T8966	33359-33363	VBD	denotes	were
T8967	33373-33375	:	denotes	:
T8968	33375-33380	NNP	denotes	David
T8969	33394-33398	NN	denotes	test
T8970	33381-33383	FW	denotes	et
T8971	33384-33387	FW	denotes	al.
T8972	33388-33393	NN	denotes	range
T8973	33399-33401	TO	denotes	to
T8974	33402-33408	VB	denotes	ensure
T8975	33409-33416	NNS	denotes	samples
T8976	33417-33420	VBP	denotes	are
T8977	33421-33425	IN	denotes	from
T8978	33426-33427	DT	denotes	a
T8979	33435-33447	NN	denotes	distribution
T8980	33428-33434	JJ	denotes	normal
T8981	33447-33449	,	denotes	,
T8982	33449-33450	NN	denotes	F
T8983	33451-33455	NN	denotes	test
T8984	33450-33451	HYPH	denotes	-
T8985	33456-33463	VBG	denotes	looking
T8986	33464-33467	IN	denotes	for
T8987	33468-33469	DT	denotes	a
T8988	33470-33477	NNS	denotes	samples
T8989	33479-33493	NN	denotes	homoscedascity
T8990	33477-33478	POS	denotes	'
T8991	33493-33495	,	denotes	,
T8992	33495-33502	NN	denotes	Student
T8993	33507-33511	NN	denotes	test
T8994	33502-33504	POS	denotes	's
T8995	33505-33506	NN	denotes	T
T8996	33506-33507	HYPH	denotes	-
T8997	33512-33514	TO	denotes	to
T8998	33515-33520	VB	denotes	judge
T8999	33521-33523	IN	denotes	if
T9000	33552-33556	VBP	denotes	have
T9001	33524-33531	NNS	denotes	samples
T9002	33532-33534	IN	denotes	of
T9003	33535-33544	JJ	denotes	different
T9004	33545-33551	NNS	denotes	groups
T9005	33557-33558	DT	denotes	a
T9006	33574-33579	NN	denotes	value
T9007	33559-33568	JJ	denotes	different
T9008	33569-33573	JJ	denotes	mean
T9009	33580-33583	CC	denotes	and
T9010	33584-33587	VBP	denotes	are
T9011	33588-33593	NNS	denotes	parts
T9012	33594-33598	IN	denotes	from
T9013	33599-33608	JJ	denotes	different
T9014	33616-33629	NNS	denotes	distributions
T9015	33609-33615	JJ	denotes	normal
T9016	33629-33630	.	denotes	.
T9017	33630-33745	sentence	denotes	The exact probability values and the significance of an analysis are indicated when the experiments are described.
T9018	33631-33634	DT	denotes	The
T9019	33653-33659	NNS	denotes	values
T9020	33635-33640	JJ	denotes	exact
T9021	33641-33652	NN	denotes	probability
T9022	33700-33709	VBN	denotes	indicated
T9023	33660-33663	CC	denotes	and
T9024	33664-33667	DT	denotes	the
T9025	33668-33680	NN	denotes	significance
T9026	33681-33683	IN	denotes	of
T9027	33684-33686	DT	denotes	an
T9028	33687-33695	NN	denotes	analysis
T9029	33696-33699	VBP	denotes	are
T9030	33710-33714	WRB	denotes	when
T9031	33735-33744	VBN	denotes	described
T9032	33715-33718	DT	denotes	the
T9033	33719-33730	NNS	denotes	experiments
T9034	33731-33734	VBP	denotes	are
T9035	33744-33745	.	denotes	.
T9089	6100-6110	NN	denotes	Expression
T9090	6111-6113	IN	denotes	of
T9091	6114-6121	NN	denotes	annexin
T9092	6122-6124	NN	denotes	A7
T9093	6125-6127	IN	denotes	in
T9094	6128-6133	JJ	denotes	human
T9095	6144-6149	NNS	denotes	cells
T9096	6134-6137	JJ	denotes	red
T9097	6138-6143	NN	denotes	blood
T9098	6150-6151	-LRB-	denotes	(
T9099	6151-6152	CD	denotes	1
T9100	6152-6153	-RRB-	denotes	)
T9101	6154-6157	CC	denotes	and
T9102	6158-6163	JJ	denotes	human
T9103	6164-6173	NNS	denotes	platelets
T9104	6174-6175	-LRB-	denotes	(
T9105	6175-6176	CD	denotes	2
T9106	6176-6177	-RRB-	denotes	)
T9107	6177-6178	.	denotes	.
T9108	6178-6244	sentence	denotes	Protein homogenates were separated by SDS-PAGE (12 % acrylamide).
T9109	6179-6186	NN	denotes	Protein
T9110	6187-6198	NNS	denotes	homogenates
T9111	6204-6213	VBN	denotes	separated
T9112	6199-6203	VBD	denotes	were
T9113	6214-6216	IN	denotes	by
T9114	6217-6220	NN	denotes	SDS
T9115	6221-6225	NN	denotes	PAGE
T9116	6220-6221	HYPH	denotes	-
T9117	6226-6227	-LRB-	denotes	(
T9118	6232-6242	NN	denotes	acrylamide
T9119	6227-6229	CD	denotes	12
T9120	6230-6231	NN	denotes	%
T9121	6242-6243	-RRB-	denotes	)
T9122	6243-6244	.	denotes	.
T9123	6244-6378	sentence	denotes	The resulting western blot was probed with mAb 203–217, visualization was by a secondary peroxidase coupled antibody followed by ECL.
T9124	6245-6248	DT	denotes	The
T9125	6267-6271	NN	denotes	blot
T9126	6249-6258	VBG	denotes	resulting
T9127	6259-6266	JJ	denotes	western
T9128	6276-6282	VBN	denotes	probed
T9129	6272-6275	VBD	denotes	was
T9130	6315-6318	VBD	denotes	was
T9131	6283-6287	IN	denotes	with
T9132	6288-6291	NN	denotes	mAb
T9133	6292-6299	CD	denotes	203–217
T9134	6299-6301	,	denotes	,
T9135	6301-6314	NN	denotes	visualization
T9136	6319-6321	IN	denotes	by
T9137	6322-6323	DT	denotes	a
T9138	6353-6361	NN	denotes	antibody
T9139	6324-6333	JJ	denotes	secondary
T9140	6334-6344	NN	denotes	peroxidase
T9141	6345-6352	VBN	denotes	coupled
T9142	6362-6370	VBN	denotes	followed
T9143	6371-6373	IN	denotes	by
T9144	6374-6377	NN	denotes	ECL
T9145	6377-6378	.	denotes	.
T9146	6378-6473	sentence	denotes	Both isoforms are detected in red blood cells, in platelets only the small isoform is present.
T9147	6379-6383	DT	denotes	Both
T9148	6384-6392	NNS	denotes	isoforms
T9149	6397-6405	VBN	denotes	detected
T9150	6393-6396	VBP	denotes	are
T9151	6462-6464	VBZ	denotes	is
T9152	6406-6408	IN	denotes	in
T9153	6409-6412	JJ	denotes	red
T9154	6419-6424	NNS	denotes	cells
T9155	6413-6418	NN	denotes	blood
T9156	6424-6426	,	denotes	,
T9157	6426-6428	IN	denotes	in
T9158	6429-6438	NNS	denotes	platelets
T9159	6439-6443	RB	denotes	only
T9160	6454-6461	NN	denotes	isoform
T9161	6444-6447	DT	denotes	the
T9162	6448-6453	JJ	denotes	small
T9163	6465-6472	JJ	denotes	present
T9164	6472-6473	.	denotes	.
T9240	7816-7826	NN	denotes	Enrichment
T9241	7827-7829	IN	denotes	of
T9242	7830-7837	NN	denotes	annexin
T9243	7838-7840	NN	denotes	A7
T9244	7841-7844	CC	denotes	and
T9245	7845-7851	NN	denotes	sorcin
T9246	7852-7854	IN	denotes	in
T9247	7855-7866	NNS	denotes	exovesicles
T9248	7867-7874	VBN	denotes	derived
T9249	7875-7879	IN	denotes	from
T9250	7880-7883	JJ	denotes	red
T9251	7890-7895	NNS	denotes	cells
T9252	7884-7889	NN	denotes	blood
T9253	7895-7896	.	denotes	.
T9254	7896-8118	sentence	denotes	Vesicles from wild type (wt) and anxA7-/- mutant (ko) were generated with Ca2+/ionophore treatment, isolated by differential centrifugation and analysed by immunoblotting with mAb 203–217 and a sorcin polyclonal antibody.
T9255	7897-7905	NNS	denotes	Vesicles
T9256	7956-7965	VBN	denotes	generated
T9257	7906-7910	IN	denotes	from
T9258	7911-7915	JJ	denotes	wild
T9259	7916-7920	NN	denotes	type
T9260	7921-7922	-LRB-	denotes	(
T9261	7922-7924	NN	denotes	wt
T9262	7924-7925	-RRB-	denotes	)
T9263	7926-7929	CC	denotes	and
T9264	7930-7935	JJ	denotes	anxA7
T9265	7939-7945	NN	denotes	mutant
T9266	7935-7936	SYM	denotes	-
T9267	7936-7937	HYPH	denotes	/
T9268	7937-7938	SYM	denotes	-
T9269	7946-7947	-LRB-	denotes	(
T9270	7947-7949	NN	denotes	ko
T9271	7949-7950	-RRB-	denotes	)
T9272	7951-7955	VBD	denotes	were
T9273	7966-7970	IN	denotes	with
T9274	7971-7975	NN	denotes	Ca2+
T9275	7976-7985	NN	denotes	ionophore
T9276	7975-7976	HYPH	denotes	/
T9277	7986-7995	NN	denotes	treatment
T9278	7995-7997	,	denotes	,
T9279	7997-8005	VBN	denotes	isolated
T9280	8006-8008	IN	denotes	by
T9281	8009-8021	JJ	denotes	differential
T9282	8022-8036	NN	denotes	centrifugation
T9283	8037-8040	CC	denotes	and
T9284	8041-8049	VBN	denotes	analysed
T9285	8050-8052	IN	denotes	by
T9286	8053-8067	VBG	denotes	immunoblotting
T9287	8068-8072	IN	denotes	with
T9288	8073-8076	NN	denotes	mAb
T9289	8077-8080	CD	denotes	203
T9290	8080-8081	SYM	denotes	–
T9291	8081-8084	CD	denotes	217
T9292	8085-8088	CC	denotes	and
T9293	8089-8090	DT	denotes	a
T9294	8109-8117	NN	denotes	antibody
T9295	8091-8097	NN	denotes	sorcin
T9296	8098-8108	JJ	denotes	polyclonal
T9297	8117-8118	.	denotes	.
T9298	8118-8187	sentence	denotes	In general, annexin A7 and sorcin are more abundant in nanovesicles.
T9299	8119-8121	IN	denotes	In
T9300	8153-8156	VBP	denotes	are
T9301	8122-8129	JJ	denotes	general
T9302	8129-8131	,	denotes	,
T9303	8131-8138	NN	denotes	annexin
T9304	8139-8141	NN	denotes	A7
T9305	8142-8145	CC	denotes	and
T9306	8146-8152	NN	denotes	sorcin
T9307	8157-8161	RBR	denotes	more
T9308	8162-8170	JJ	denotes	abundant
T9309	8171-8173	IN	denotes	in
T9310	8174-8186	NNS	denotes	nanovesicles
T9311	8186-8187	.	denotes	.
T9312	8187-8263	sentence	denotes	The 51 kDa isoform of annexin A7 (arrows) is only observed in nanovesicles.
T9313	8188-8191	DT	denotes	The
T9314	8199-8206	NN	denotes	isoform
T9315	8192-8194	CD	denotes	51
T9316	8195-8198	NN	denotes	kDa
T9317	8238-8246	VBN	denotes	observed
T9318	8207-8209	IN	denotes	of
T9319	8210-8217	NN	denotes	annexin
T9320	8218-8220	NN	denotes	A7
T9321	8221-8222	-LRB-	denotes	(
T9322	8222-8228	NNS	denotes	arrows
T9323	8228-8229	-RRB-	denotes	)
T9324	8230-8232	VBZ	denotes	is
T9325	8233-8237	RB	denotes	only
T9326	8247-8249	IN	denotes	in
T9327	8250-8262	NNS	denotes	nanovesicles
T9328	8262-8263	.	denotes	.
T9329	8263-8362	sentence	denotes	Samples of both vesicles types were normalized according to their acetylcholine esterase activity.
T9330	8264-8271	NNS	denotes	Samples
T9331	8300-8310	VBN	denotes	normalized
T9332	8272-8274	IN	denotes	of
T9333	8275-8279	DT	denotes	both
T9334	8289-8294	NNS	denotes	types
T9335	8280-8288	NNS	denotes	vesicles
T9336	8295-8299	VBD	denotes	were
T9337	8311-8320	VBG	denotes	according
T9338	8321-8323	IN	denotes	to
T9339	8324-8329	PRP$	denotes	their
T9340	8353-8361	NN	denotes	activity
T9341	8330-8343	NN	denotes	acetylcholine
T9342	8344-8352	NN	denotes	esterase
T9343	8361-8362	.	denotes	.
T9344	8362-8441	sentence	denotes	Human red blood cells (co) were used for control and normalized independently.
T9345	8363-8368	JJ	denotes	Human
T9346	8379-8384	NNS	denotes	cells
T9347	8369-8372	JJ	denotes	red
T9348	8373-8378	NN	denotes	blood
T9349	8395-8399	VBN	denotes	used
T9350	8385-8386	-LRB-	denotes	(
T9351	8386-8388	NN	denotes	co
T9352	8388-8389	-RRB-	denotes	)
T9353	8390-8394	VBD	denotes	were
T9354	8400-8403	IN	denotes	for
T9355	8404-8411	NN	denotes	control
T9356	8412-8415	CC	denotes	and
T9357	8416-8426	VBD	denotes	normalized
T9358	8427-8440	RB	denotes	independently
T9359	8440-8441	.	denotes	.
T9397	9289-9300	NN	denotes	Association
T9398	9301-9303	IN	denotes	of
T9399	9304-9311	NN	denotes	annexin
T9400	9312-9314	NN	denotes	A7
T9401	9315-9318	CC	denotes	and
T9402	9319-9325	NN	denotes	sorcin
T9403	9326-9330	IN	denotes	with
T9404	9331-9339	JJ	denotes	distinct
T9405	9371-9380	NNS	denotes	fractions
T9406	9340-9343	JJ	denotes	red
T9407	9350-9354	NN	denotes	cell
T9408	9344-9349	NN	denotes	blood
T9409	9355-9361	NN	denotes	plasma
T9410	9362-9370	NN	denotes	membrane
T9411	9380-9381	.	denotes	.
T9412	9381-9466	sentence	denotes	Lysed human red blood cells were added to a self forming iodixanol density gradient.
T9413	9382-9387	VBN	denotes	Lysed
T9414	9404-9409	NNS	denotes	cells
T9415	9388-9393	JJ	denotes	human
T9416	9394-9397	JJ	denotes	red
T9417	9398-9403	NN	denotes	blood
T9418	9415-9420	VBN	denotes	added
T9419	9410-9414	VBD	denotes	were
T9420	9421-9423	IN	denotes	to
T9421	9424-9425	DT	denotes	a
T9422	9457-9465	NN	denotes	gradient
T9423	9426-9430	NN	denotes	self
T9424	9431-9438	VBG	denotes	forming
T9425	9439-9448	NN	denotes	iodixanol
T9426	9449-9456	NN	denotes	density
T9427	9465-9466	.	denotes	.
T9428	9466-9548	sentence	denotes	The density of the gradient increases from left (1.06 g/ml) to right (1.20 g/ml).
T9429	9467-9470	DT	denotes	The
T9430	9471-9478	NN	denotes	density
T9431	9495-9504	VBZ	denotes	increases
T9432	9479-9481	IN	denotes	of
T9433	9482-9485	DT	denotes	the
T9434	9486-9494	NN	denotes	gradient
T9435	9505-9509	IN	denotes	from
T9436	9510-9514	JJ	denotes	left
T9437	9515-9516	-LRB-	denotes	(
T9438	9521-9522	NNS	denotes	g
T9439	9516-9520	CD	denotes	1.06
T9440	9522-9523	SYM	denotes	/
T9441	9523-9525	NN	denotes	ml
T9442	9525-9526	-RRB-	denotes	)
T9443	9527-9529	IN	denotes	to
T9444	9530-9535	JJ	denotes	right
T9445	9536-9537	-LRB-	denotes	(
T9446	9542-9543	NNS	denotes	g
T9447	9537-9541	CD	denotes	1.20
T9448	9543-9544	SYM	denotes	/
T9449	9544-9546	NN	denotes	ml
T9450	9546-9547	-RRB-	denotes	)
T9451	9547-9548	.	denotes	.
T9452	9548-9644	sentence	denotes	Fractions were analysed by immunoblotting using mAb 203–217 and the sorcin polyclonal antibody.
T9453	9549-9558	NNS	denotes	Fractions
T9454	9564-9572	VBN	denotes	analysed
T9455	9559-9563	VBD	denotes	were
T9456	9573-9575	IN	denotes	by
T9457	9576-9590	NN	denotes	immunoblotting
T9458	9591-9596	VBG	denotes	using
T9459	9597-9600	NN	denotes	mAb
T9460	9601-9604	CD	denotes	203
T9461	9604-9605	SYM	denotes	–
T9462	9605-9608	CD	denotes	217
T9463	9609-9612	CC	denotes	and
T9464	9613-9616	DT	denotes	the
T9465	9635-9643	NN	denotes	antibody
T9466	9617-9623	NN	denotes	sorcin
T9467	9624-9634	JJ	denotes	polyclonal
T9468	9643-9644	.	denotes	.
T9533	10598-10609	JJ	denotes	significant
T9534	10610-10611	-LRB-	denotes	(
T9535	10626-10628	CD	denotes	40
T9536	10611-10612	NN	denotes	p
T9537	10615-10620	CD	denotes	0.015
T9538	10613-10614	SYM	denotes	=
T9539	10620-10621	:	denotes	;
T9540	10622-10623	NN	denotes	n
T9541	10624-10625	SYM	denotes	=
T9542	10628-10629	-RRB-	denotes	)
T9543	10629-10630	.	denotes	.
T9544	10630-10641	sentence	denotes	Bar, 3 μm.
T9545	10631-10634	NN	denotes	Bar
T9546	10638-10640	NNS	denotes	μm
T9547	10634-10636	,	denotes	,
T9548	10636-10637	CD	denotes	3
T9549	10640-10641	.	denotes	.
T9617	12721-12728	JJ	denotes	Osmotic
T9618	12729-12739	NN	denotes	resistance
T9619	12740-12746	NNS	denotes	curves
T9620	12747-12749	IN	denotes	of
T9621	12750-12753	JJ	denotes	red
T9622	12760-12765	NNS	denotes	cells
T9623	12754-12759	NN	denotes	blood
T9624	12766-12770	IN	denotes	from
T9625	12771-12775	JJ	denotes	wild
T9626	12776-12780	NN	denotes	type
T9627	12801-12805	NNS	denotes	mice
T9628	12781-12784	CC	denotes	and
T9629	12785-12790	NN	denotes	anxA7
T9630	12790-12791	SYM	denotes	-
T9631	12791-12792	HYPH	denotes	/
T9632	12792-12793	SYM	denotes	-
T9633	12794-12800	JJ	denotes	mutant
T9634	12805-12806	.	denotes	.
T9635	12806-12949	sentence	denotes	The osmotic resistance towards changes in the extracellular ionic strength is a convenient assay for analysis of the red blood cell integrity.
T9636	12807-12810	DT	denotes	The
T9637	12819-12829	NN	denotes	resistance
T9638	12811-12818	JJ	denotes	osmotic
T9639	12882-12884	VBZ	denotes	is
T9640	12830-12837	IN	denotes	towards
T9641	12838-12845	NNS	denotes	changes
T9642	12846-12848	IN	denotes	in
T9643	12849-12852	DT	denotes	the
T9644	12873-12881	NN	denotes	strength
T9645	12853-12866	JJ	denotes	extracellular
T9646	12867-12872	JJ	denotes	ionic
T9647	12885-12886	DT	denotes	a
T9648	12898-12903	NN	denotes	assay
T9649	12887-12897	JJ	denotes	convenient
T9650	12904-12907	IN	denotes	for
T9651	12908-12916	NN	denotes	analysis
T9652	12917-12919	IN	denotes	of
T9653	12920-12923	DT	denotes	the
T9654	12939-12948	NN	denotes	integrity
T9655	12924-12927	JJ	denotes	red
T9656	12934-12938	NN	denotes	cell
T9657	12928-12933	NN	denotes	blood
T9658	12948-12949	.	denotes	.
T9659	12949-13116	sentence	denotes	It is measured as a sodium chloride concentration in which cellular lysis starts (minimal resistance) up to a complete lysis (maximal resistance) of a red blood cell.
T9660	12950-12952	PRP	denotes	It
T9661	12956-12964	VBN	denotes	measured
T9662	12953-12955	VBZ	denotes	is
T9663	12965-12967	IN	denotes	as
T9664	12968-12969	DT	denotes	a
T9665	12986-12999	NN	denotes	concentration
T9666	12970-12976	NN	denotes	sodium
T9667	12977-12985	NN	denotes	chloride
T9668	13000-13002	IN	denotes	in
T9669	13024-13030	VBZ	denotes	starts
T9670	13003-13008	WDT	denotes	which
T9671	13009-13017	JJ	denotes	cellular
T9672	13018-13023	NN	denotes	lysis
T9673	13031-13032	-LRB-	denotes	(
T9674	13040-13050	NN	denotes	resistance
T9675	13032-13039	JJ	denotes	minimal
T9676	13050-13051	-RRB-	denotes	)
T9677	13052-13054	IN	denotes	up
T9678	13055-13057	IN	denotes	to
T9679	13058-13059	DT	denotes	a
T9680	13069-13074	NN	denotes	lysis
T9681	13060-13068	JJ	denotes	complete
T9682	13075-13076	-LRB-	denotes	(
T9683	13084-13094	NN	denotes	resistance
T9684	13076-13083	JJ	denotes	maximal
T9685	13094-13095	-RRB-	denotes	)
T9686	13096-13098	IN	denotes	of
T9687	13099-13100	DT	denotes	a
T9688	13111-13115	NN	denotes	cell
T9689	13101-13104	JJ	denotes	red
T9690	13105-13110	NN	denotes	blood
T9691	13115-13116	.	denotes	.
T9692	13116-13261	sentence	denotes	The osmotic resistance of annexin A7 deficient red blood cells is significantly increased compared to the one of wild type (p = 0.00066; n = 8).
T9693	13117-13120	DT	denotes	The
T9694	13129-13139	NN	denotes	resistance
T9695	13121-13128	JJ	denotes	osmotic
T9696	13180-13182	VBZ	denotes	is
T9697	13140-13142	IN	denotes	of
T9698	13143-13150	NN	denotes	annexin
T9699	13151-13153	NN	denotes	A7
T9700	13154-13163	JJ	denotes	deficient
T9701	13174-13179	NNS	denotes	cells
T9702	13164-13167	JJ	denotes	red
T9703	13168-13173	NN	denotes	blood
T9704	13183-13196	RB	denotes	significantly
T9705	13197-13206	JJ	denotes	increased
T9706	13207-13215	VBN	denotes	compared
T9707	13216-13218	IN	denotes	to
T9708	13219-13222	DT	denotes	the
T9709	13223-13226	CD	denotes	one
T9710	13227-13229	IN	denotes	of
T9711	13230-13234	JJ	denotes	wild
T9712	13235-13239	NN	denotes	type
T9713	13240-13241	-LRB-	denotes	(
T9714	13258-13259	CD	denotes	8
T9715	13241-13242	NN	denotes	p
T9716	13245-13252	CD	denotes	0.00066
T9717	13243-13244	SYM	denotes	=
T9718	13252-13253	:	denotes	;
T9719	13254-13255	NN	denotes	n
T9720	13256-13257	SYM	denotes	=
T9721	13259-13260	-RRB-	denotes	)
T9722	13260-13261	.	denotes	.
T9783	15958-15966	NN	denotes	Platelet
T9784	15967-15978	NN	denotes	aggregation
T9785	15979-15985	NNS	denotes	curves
T9786	15986-15990	IN	denotes	from
T9787	15991-15999	NN	denotes	platelet
T9788	16000-16004	JJ	denotes	rich
T9789	16005-16011	NN	denotes	plasma
T9790	16012-16014	IN	denotes	of
T9791	16015-16022	NN	denotes	annexin
T9792	16023-16025	NN	denotes	A7
T9793	16050-16054	NNS	denotes	mice
T9794	16026-16031	NN	denotes	knock
T9795	16032-16035	NN	denotes	out
T9796	16036-16039	CC	denotes	and
T9797	16040-16044	JJ	denotes	wild
T9798	16045-16049	NN	denotes	type
T9799	16054-16055	.	denotes	.
T9800	16055-16170	sentence	denotes	The transmission values were measured with an APACT photometer and aggregation was initiated by adding ristocetin.
T9801	16056-16059	DT	denotes	The
T9802	16073-16079	NNS	denotes	values
T9803	16060-16072	NN	denotes	transmission
T9804	16085-16093	VBN	denotes	measured
T9805	16080-16084	VBD	denotes	were
T9806	16094-16098	IN	denotes	with
T9807	16099-16101	DT	denotes	an
T9808	16108-16118	NN	denotes	photometer
T9809	16102-16107	NN	denotes	APACT
T9810	16119-16122	CC	denotes	and
T9811	16123-16134	NN	denotes	aggregation
T9812	16139-16148	VBN	denotes	initiated
T9813	16135-16138	VBD	denotes	was
T9814	16149-16151	IN	denotes	by
T9815	16152-16158	VBG	denotes	adding
T9816	16159-16169	NN	denotes	ristocetin
T9817	16169-16170	.	denotes	.
T9818	16170-16206	sentence	denotes	The first thirty seconds are given.
T9819	16171-16174	DT	denotes	The
T9820	16188-16195	NNS	denotes	seconds
T9821	16175-16180	JJ	denotes	first
T9822	16181-16187	CD	denotes	thirty
T9823	16200-16205	VBN	denotes	given
T9824	16196-16199	VBP	denotes	are
T9825	16205-16206	.	denotes	.
T9826	16206-16269	sentence	denotes	Constant platelet counts were used throughout all experiments.
T9827	16207-16215	JJ	denotes	Constant
T9828	16225-16231	NNS	denotes	counts
T9829	16216-16224	NN	denotes	platelet
T9830	16237-16241	VBN	denotes	used
T9831	16232-16236	VBD	denotes	were
T9832	16242-16252	IN	denotes	throughout
T9833	16253-16256	DT	denotes	all
T9834	16257-16268	NNS	denotes	experiments
T9835	16268-16269	.	denotes	.
T9836	16269-16402	sentence	denotes	The aggregation curve data were analysed for slope values, the maximal aggregation amplitude of every single curve was set to 100 %.
T9837	16270-16273	DT	denotes	The
T9838	16292-16296	NNS	denotes	data
T9839	16274-16285	NN	denotes	aggregation
T9840	16286-16291	NN	denotes	curve
T9841	16302-16310	VBN	denotes	analysed
T9842	16297-16301	VBD	denotes	were
T9843	16389-16392	VBN	denotes	set
T9844	16311-16314	IN	denotes	for
T9845	16315-16320	NN	denotes	slope
T9846	16321-16327	NNS	denotes	values
T9847	16327-16329	,	denotes	,
T9848	16329-16332	DT	denotes	the
T9849	16353-16362	NN	denotes	amplitude
T9850	16333-16340	JJ	denotes	maximal
T9851	16341-16352	NN	denotes	aggregation
T9852	16363-16365	IN	denotes	of
T9853	16366-16371	DT	denotes	every
T9854	16379-16384	NN	denotes	curve
T9855	16372-16378	JJ	denotes	single
T9856	16385-16388	VBD	denotes	was
T9857	16393-16395	IN	denotes	to
T9858	16396-16399	CD	denotes	100
T9859	16400-16401	NN	denotes	%
T9860	16401-16402	.	denotes	.
T9861	16402-16778	sentence	denotes	Both murine curves differ significantly at a time point of seven seconds after platelet initiation, the mutant shows a slightly lower aggregation velocity (p = 0.0287, n knock out = 16, n wild type = 15, mean knock out = 67.7 % transmission, mean wild type = 77.1 % transmission, standard error knock out = 8.3 % transmission, standard error wild type = 13.8 % transmission).
T9862	16403-16407	DT	denotes	Both
T9863	16415-16421	NNS	denotes	curves
T9864	16408-16414	JJ	denotes	murine
T9865	16422-16428	VBP	denotes	differ
T9866	16514-16519	VBZ	denotes	shows
T9867	16429-16442	RB	denotes	significantly
T9868	16443-16445	IN	denotes	at
T9869	16446-16447	DT	denotes	a
T9870	16453-16458	NN	denotes	point
T9871	16448-16452	NN	denotes	time
T9872	16459-16461	IN	denotes	of
T9873	16462-16467	CD	denotes	seven
T9874	16468-16475	NNS	denotes	seconds
T9875	16476-16481	IN	denotes	after
T9876	16482-16490	NN	denotes	platelet
T9877	16491-16501	NN	denotes	initiation
T9878	16501-16503	,	denotes	,
T9879	16503-16506	DT	denotes	the
T9880	16507-16513	NN	denotes	mutant
T9881	16520-16521	DT	denotes	a
T9882	16549-16557	NN	denotes	velocity
T9883	16522-16530	RB	denotes	slightly
T9884	16531-16536	JJR	denotes	lower
T9885	16537-16548	NN	denotes	aggregation
T9886	16558-16559	-LRB-	denotes	(
T9887	16764-16776	NN	denotes	transmission
T9888	16559-16560	NN	denotes	p
T9889	16563-16569	CD	denotes	0.0287
T9890	16561-16562	SYM	denotes	=
T9891	16569-16571	,	denotes	,
T9892	16571-16572	NN	denotes	n
T9893	16579-16582	NN	denotes	out
T9894	16573-16578	NN	denotes	knock
T9895	16585-16587	CD	denotes	16
T9896	16583-16584	SYM	denotes	=
T9897	16587-16589	,	denotes	,
T9898	16589-16590	NN	denotes	n
T9899	16596-16600	NN	denotes	type
T9900	16591-16595	JJ	denotes	wild
T9901	16603-16605	CD	denotes	15
T9902	16601-16602	SYM	denotes	=
T9903	16605-16607	,	denotes	,
T9904	16607-16611	JJ	denotes	mean
T9905	16618-16621	NN	denotes	out
T9906	16612-16617	NN	denotes	knock
T9907	16631-16643	NN	denotes	transmission
T9908	16622-16623	SYM	denotes	=
T9909	16624-16628	CD	denotes	67.7
T9910	16629-16630	NN	denotes	%
T9911	16643-16645	,	denotes	,
T9912	16645-16649	JJ	denotes	mean
T9913	16655-16659	NN	denotes	type
T9914	16650-16654	JJ	denotes	wild
T9915	16669-16681	NN	denotes	transmission
T9916	16660-16661	SYM	denotes	=
T9917	16662-16666	CD	denotes	77.1
T9918	16667-16668	NN	denotes	%
T9919	16681-16683	,	denotes	,
T9920	16683-16691	JJ	denotes	standard
T9921	16692-16697	NN	denotes	error
T9922	16704-16707	NN	denotes	out
T9923	16698-16703	NN	denotes	knock
T9924	16716-16728	NN	denotes	transmission
T9925	16708-16709	SYM	denotes	=
T9926	16710-16713	CD	denotes	8.3
T9927	16714-16715	NN	denotes	%
T9928	16728-16730	,	denotes	,
T9929	16730-16738	JJ	denotes	standard
T9930	16739-16744	NN	denotes	error
T9931	16750-16754	NN	denotes	type
T9932	16745-16749	JJ	denotes	wild
T9933	16755-16756	SYM	denotes	=
T9934	16757-16761	CD	denotes	13.8
T9935	16762-16763	NN	denotes	%
T9936	16776-16777	-RRB-	denotes	)
T9937	16777-16778	.	denotes	.
T9938	16778-16895	sentence	denotes	Murine platelets react immediately to the initiating chemical and show no lag phase like the normal human platelets.
T9939	16779-16785	JJ	denotes	Murine
T9940	16786-16795	NNS	denotes	platelets
T9941	16796-16801	VBP	denotes	react
T9942	16802-16813	RB	denotes	immediately
T9943	16814-16816	IN	denotes	to
T9944	16817-16820	DT	denotes	the
T9945	16832-16840	NN	denotes	chemical
T9946	16821-16831	VBG	denotes	initiating
T9947	16841-16844	CC	denotes	and
T9948	16845-16849	VBP	denotes	show
T9949	16850-16852	DT	denotes	no
T9950	16857-16862	NN	denotes	phase
T9951	16853-16856	NN	denotes	lag
T9952	16863-16867	IN	denotes	like
T9953	16868-16871	DT	denotes	the
T9954	16885-16894	NNS	denotes	platelets
T9955	16872-16878	JJ	denotes	normal
T9956	16879-16884	JJ	denotes	human
T9957	16894-16895	.	denotes	.
T9958	16895-17029	sentence	denotes	For comparison of the range of the platelet impairment slightly affected human platelets are shown as well (von Willebrand syndrome).
T9959	16896-16899	IN	denotes	For
T9960	16989-16994	VBN	denotes	shown
T9961	16900-16910	NN	denotes	comparison
T9962	16911-16913	IN	denotes	of
T9963	16914-16917	DT	denotes	the
T9964	16918-16923	NN	denotes	range
T9965	16924-16926	IN	denotes	of
T9966	16927-16930	DT	denotes	the
T9967	16940-16950	NN	denotes	impairment
T9968	16931-16939	NN	denotes	platelet
T9969	16951-16959	RB	denotes	slightly
T9970	16960-16968	VBN	denotes	affected
T9971	16975-16984	NNS	denotes	platelets
T9972	16969-16974	JJ	denotes	human
T9973	16985-16988	VBP	denotes	are
T9974	16995-16997	RB	denotes	as
T9975	16998-17002	RB	denotes	well
T9976	17003-17004	-LRB-	denotes	(
T9977	17019-17027	NN	denotes	syndrome
T9978	17004-17007	NNP	denotes	von
T9979	17008-17018	NNP	denotes	Willebrand
T9980	17027-17028	-RRB-	denotes	)
T9981	17028-17029	.	denotes	.
T2865	8471-8478	NN	denotes	annexin
T2866	8479-8481	NN	denotes	A7
T2867	8482-8484	IN	denotes	in
T2868	8485-8488	JJ	denotes	red
T2869	8495-8500	NNS	denotes	cells
T9489	10404-10408	JJ	denotes	Dark
T9490	10409-10414	NN	denotes	field
T9491	10415-10425	NN	denotes	microscopy
T9492	10426-10428	IN	denotes	of
T9493	10429-10432	JJ	denotes	red
T9494	10439-10444	NNS	denotes	cells
T9495	10433-10438	NN	denotes	blood
T9496	10445-10449	IN	denotes	from
T9497	10450-10455	JJ	denotes	anxA7
T9498	10459-10465	NN	denotes	mutant
T9499	10455-10456	SYM	denotes	-
T9500	10456-10457	HYPH	denotes	/
T9501	10457-10458	SYM	denotes	-
T9502	10484-10488	NNS	denotes	mice
T9503	10466-10467	-LRB-	denotes	(
T9504	10467-10468	NN	denotes	B
T9505	10468-10469	-RRB-	denotes	)
T9506	10470-10473	CC	denotes	and
T9507	10474-10478	JJ	denotes	wild
T9508	10479-10483	NN	denotes	type
T9509	10489-10490	-LRB-	denotes	(
T9510	10490-10491	NN	denotes	A
T9511	10491-10492	-RRB-	denotes	)
T9512	10492-10493	.	denotes	.
T9513	10493-10558	sentence	denotes	The mean cellular diameters are 6.0 μm and 5.7 μm, respectively.
T9514	10494-10497	DT	denotes	The
T9515	10512-10521	NNS	denotes	diameters
T9516	10498-10502	JJ	denotes	mean
T9517	10503-10511	JJ	denotes	cellular
T9518	10522-10525	VBP	denotes	are
T9519	10526-10529	CD	denotes	6.0
T9520	10530-10532	NNS	denotes	μm
T9521	10533-10536	CC	denotes	and
T9522	10537-10540	CD	denotes	5.7
T9523	10541-10543	NNS	denotes	μm
T9524	10543-10545	,	denotes	,
T9525	10545-10557	RB	denotes	respectively
T9526	10557-10558	.	denotes	.
T9527	10558-10630	sentence	denotes	The size differences are statistically significant (p = 0.015; n = 40).
T9528	10559-10562	DT	denotes	The
T9529	10568-10579	NNS	denotes	differences
T9530	10563-10567	NN	denotes	size
T9531	10580-10583	VBP	denotes	are
T9532	10584-10597	RB	denotes	statistically
T2870	8489-8494	NN	denotes	blood
T2871	8501-8503	PRP	denotes	we
T2872	8509-8513	NN	denotes	self
T2873	8514-8521	VBG	denotes	forming
T2874	8540-8549	NNS	denotes	gradients
T2554	5899-5906	NN	denotes	isoform
T2555	5892-5894	CD	denotes	47
T2556	5895-5898	NN	denotes	kDa
T2557	5911-5919	VBN	denotes	detected
T2558	5907-5910	VBD	denotes	was
T2559	5920-5922	IN	denotes	in
T2560	5923-5929	NN	denotes	silver
T2561	5930-5937	VBN	denotes	stained
T2562	5938-5942	NNS	denotes	gels
T2563	5943-5946	CC	denotes	and
T2564	5947-5950	PRP$	denotes	its
T2565	5951-5959	NN	denotes	identity
T2566	5976-5985	VBN	denotes	confirmed
T2567	5960-5964	IN	denotes	with
T2568	5965-5972	NN	denotes	annexin
T2569	5973-5975	NN	denotes	A7
T2570	5986-5988	IN	denotes	by
T2571	5989-5996	NN	denotes	peptide
T2572	6002-6016	NN	denotes	fingerprinting
T2573	5997-6001	NN	denotes	mass
T2574	6017-6018	-LRB-	denotes	(
T2575	6027-6032	VBN	denotes	shown
T2576	6018-6022	NNS	denotes	data
T2577	6023-6026	RB	denotes	not
T2578	6032-6033	-RRB-	denotes	)
T2579	6033-6034	.	denotes	.
T2580	6034-6089	sentence	denotes	The 51 kDa isoform was only detected in western blots.
T2581	6035-6038	DT	denotes	The
T2582	6046-6053	NN	denotes	isoform
T2583	6039-6041	CD	denotes	51
T2584	6042-6045	NN	denotes	kDa
T2585	6063-6071	VBN	denotes	detected
T2586	6054-6057	VBD	denotes	was
T2587	6058-6062	RB	denotes	only
T2588	6072-6074	IN	denotes	in
T2589	6075-6082	JJ	denotes	western
T2590	6083-6088	NNS	denotes	blots
T2591	6088-6089	.	denotes	.
T2592	6089-6090	sentence	denotes
T2593	6474-6631	sentence	denotes	Its presence in vesicles led to the suggestion, that, along with raft domains, annexin A7 plays a role in membrane organization and the vesiculation process.
T2594	6474-6477	PRP$	denotes	Its
T2595	6478-6486	NN	denotes	presence
T2596	6499-6502	VBD	denotes	led
T2597	6487-6489	IN	denotes	in
T2598	6490-6498	NNS	denotes	vesicles
T2599	6503-6505	IN	denotes	to
T2600	6506-6509	DT	denotes	the
T2601	6510-6520	NN	denotes	suggestion
T2602	6520-6522	,	denotes	,
T2603	6522-6526	IN	denotes	that
T2604	6564-6569	VBZ	denotes	plays
T2605	6526-6528	,	denotes	,
T2875	8522-8531	NN	denotes	iodixanol
T2792	7483-7484	.	denotes	.
T2793	7484-7648	sentence	denotes	It appears that annexin A7, although it has been described to fuse membranes, is not a key component in the process of the formation of red blood cell exovesicles.
T2794	7485-7487	PRP	denotes	It
T2795	7488-7495	VBZ	denotes	appears
T2796	7496-7500	IN	denotes	that
T2797	7563-7565	VBZ	denotes	is
T2798	7501-7508	NN	denotes	annexin
T2799	7509-7511	NN	denotes	A7
T2800	7511-7513	,	denotes	,
T2801	7513-7521	IN	denotes	although
T2802	7534-7543	VBN	denotes	described
T2803	7522-7524	PRP	denotes	it
T2804	7525-7528	VBZ	denotes	has
T2805	7529-7533	VBN	denotes	been
T2806	7544-7546	TO	denotes	to
T2807	7547-7551	VB	denotes	fuse
T2808	7552-7561	NNS	denotes	membranes
T2809	7561-7563	,	denotes	,
T2810	7566-7569	RB	denotes	not
T2811	7570-7571	DT	denotes	a
T2812	7576-7585	NN	denotes	component
T2813	7572-7575	JJ	denotes	key
T2814	7586-7588	IN	denotes	in
T2815	7589-7592	DT	denotes	the
T2816	7593-7600	NN	denotes	process
T2817	7601-7603	IN	denotes	of
T2818	7604-7607	DT	denotes	the
T2819	7608-7617	NN	denotes	formation
T2820	7618-7620	IN	denotes	of
T2821	7621-7624	JJ	denotes	red
T2822	7631-7635	NN	denotes	cell
T2823	7625-7630	NN	denotes	blood
T2824	7636-7647	NNS	denotes	exovesicles
T2825	7647-7648	.	denotes	.
T2826	7648-7805	sentence	denotes	When we probed for the presence of sorcin in wild type and mutant vesicles we found that the sorcin levels were reduced in the mutant nanovesicles (Fig. 2).
T2827	7649-7653	WRB	denotes	When
T2828	7657-7663	VBD	denotes	probed
T2829	7654-7656	PRP	denotes	we
T2830	7727-7732	VBD	denotes	found
T2831	7664-7667	IN	denotes	for
T2858	7805-8550	sentence	denotes	Figure 2 Enrichment of annexin A7 and sorcin in exovesicles derived from red blood cells. Vesicles from wild type (wt) and anxA7-/- mutant (ko) were generated with Ca2+/ionophore treatment, isolated by differential centrifugation and analysed by immunoblotting with mAb 203–217 and a sorcin polyclonal antibody. In general, annexin A7 and sorcin are more abundant in nanovesicles. The 51 kDa isoform of annexin A7 (arrows) is only observed in nanovesicles. Samples of both vesicles types were normalized according to their acetylcholine esterase activity. Human red blood cells (co) were used for control and normalized independently. To study the distribution of annexin A7 in red blood cells we used self forming iodixanol density gradients.
T2859	8442-8444	TO	denotes	To
T2860	8445-8450	VB	denotes	study
T2861	8504-8508	VBD	denotes	used
T2862	8451-8454	DT	denotes	the
T2863	8455-8467	NN	denotes	distribution
T2864	8468-8470	IN	denotes	of
T2876	8532-8539	NN	denotes	density
T2877	8549-8550	.	denotes	.
T2878	8550-8694	sentence	denotes	Both isoforms were present in the soluble fraction as well as in the gradient fractions where they are assumed to be associated with membranes.
T2879	8551-8555	DT	denotes	Both
T3356	10034-10039	NN	denotes	shape
T3357	10040-10043	CC	denotes	and
T3358	10044-10052	NN	denotes	diameter
T3359	10053-10055	IN	denotes	of
T3360	10056-10059	DT	denotes	the
T3361	10078-10083	NNS	denotes	cells
T3362	10060-10065	JJ	denotes	anxA7
T3363	10065-10066	SYM	denotes	-
T3364	10066-10067	HYPH	denotes	/
T3365	10067-10068	SYM	denotes	-
T3366	10068-10071	JJ	denotes	red
T3367	10072-10077	NN	denotes	blood
T3368	10083-10084	.	denotes	.
T3369	10084-10288	sentence	denotes	They had a statistically significant larger cell diameter of 6.0 μm compared to wild type with 5.7 μm (p = 0.015, n = 40), a remarkably lower emphasized central impression and a more flat shape (Fig. 4).
T3370	10085-10089	PRP	denotes	They
T3371	10090-10093	VBD	denotes	had
T3372	10094-10095	DT	denotes	a
T3373	10134-10142	NN	denotes	diameter
T3374	10096-10109	RB	denotes	statistically
T3375	10110-10121	JJ	denotes	significant
T3376	10122-10128	JJR	denotes	larger
T3377	10129-10133	NN	denotes	cell
T3378	10143-10145	IN	denotes	of
T3379	10146-10149	CD	denotes	6.0
T3380	10150-10152	NN	denotes	μm
T3381	10153-10161	VBN	denotes	compared
T3436	10642-10733	sentence	denotes	Shape and MCV of a red blood cell essentially influence its function and capillary passage.
T3437	10642-10647	NN	denotes	Shape
T3438	10688-10697	VB	denotes	influence
T3439	10648-10651	CC	denotes	and
T3440	10652-10655	NN	denotes	MCV
T3441	10656-10658	IN	denotes	of
T3442	10659-10660	DT	denotes	a
T3443	10671-10675	NN	denotes	cell
T3444	10661-10664	JJ	denotes	red
T3445	10665-10670	NN	denotes	blood
T3446	10676-10687	RB	denotes	essentially
T3447	10698-10701	PRP$	denotes	its
T3448	10702-10710	NN	denotes	function
T3449	10711-10714	CC	denotes	and
T3450	10715-10724	JJ	denotes	capillary
T3451	10725-10732	NN	denotes	passage
T3452	10732-10733	.	denotes	.
T3453	10733-10907	sentence	denotes	The typical biconcave form depends on various influences including the membrane lipid composition and the submembranous cytoskeleton [32] where annexin A7 might play a role.
T3454	10734-10737	DT	denotes	The
T3455	10756-10760	NN	denotes	form
T3456	10738-10745	JJ	denotes	typical
T3457	10746-10755	NN	denotes	biconcave
T3458	10761-10768	VBZ	denotes	depends
T3459	10769-10771	IN	denotes	on
T3460	10772-10779	JJ	denotes	various
T3461	10780-10790	NNS	denotes	influences
T3462	10791-10800	VBG	denotes	including
T3463	10801-10804	DT	denotes	the
T3464	10820-10831	NN	denotes	composition
T3465	10805-10813	NN	denotes	membrane
T3466	10814-10819	NN	denotes	lipid
T3467	10832-10835	CC	denotes	and
T3468	10836-10839	DT	denotes	the
T3469	10854-10866	NN	denotes	cytoskeleton
T3470	10840-10853	JJ	denotes	submembranous
T3471	10867-10868	-LRB-	denotes	[
T3472	10868-10870	CD	denotes	32
T3473	10870-10871	-RRB-	denotes	]
T3474	10872-10877	WRB	denotes	where
T3715	12095-12098	DT	denotes	the
T3716	12123-12136	NN	denotes	deformability
T3717	12099-12102	JJ	denotes	red
T1134	11-18	NN	denotes	Annexin
T6556	24443-24447	IN	denotes	like
T6557	24448-24451	DT	denotes	the
T6558	24487-24498	NNS	denotes	differences
T6559	24452-24460	NN	denotes	platelet
T6560	24461-24468	NN	denotes	antigen
T6561	24469-24481	NN	denotes	polymorphism
T6562	24482-24483	-LRB-	denotes	[
T6563	24483-24485	CD	denotes	53
T6564	24485-24486	-RRB-	denotes	]
T6565	24499-24504	MD	denotes	might
T6566	24512-24520	JJ	denotes	apparent
T6567	24520-24521	.	denotes	.
R314	T1134	T1135	compound	Annexin,A7
R315	T1135	T1136	nsubj	A7,is
R316	T1137	T1138	det	a,protein
R317	T1138	T1136	attr	protein,is
R318	T1139	T1140	npadvmod	Ca2+,binding
R319	T1140	T1138	amod	binding,protein
R320	T1141	T1139	punct	-,Ca2+
R321	T1142	T1139	cc	and,Ca2+
R322	T1143	T1139	conj	phospholipid,Ca2+
R323	T1144	T1140	punct	-,binding
R324	T1145	T1138	punct	", ",protein
R325	T1146	T1147	dep	which,isolated
R326	T1147	T1138	relcl	isolated,protein
R327	T1148	T1147	auxpass	was,isolated
R328	T1149	T1147	prep	as,isolated
R329	T1150	T1151	det	the,agent
R330	T1151	T1149	pobj	agent,as
R331	T1152	T1153	dep	that,mediated
R332	T1153	T1151	relcl	mediated,agent
R333	T1154	T1153	dobj	aggregation,mediated
R334	T1155	T1154	prep	of,aggregation
R335	T1156	T1157	compound	chromaffin,granules
R336	T1157	T1155	pobj	granules,of
R337	T1158	T1154	cc	and,aggregation
R338	T1159	T1154	conj	fusion,aggregation
R339	T1160	T1159	prep	of,fusion
R340	T1161	T1162	compound	phospholipid,membranes
R341	T1162	T1160	pobj	membranes,of
R342	T1163	T1154	prep	in,aggregation
R343	T1164	T1165	det	the,presence
R344	T1165	T1163	pobj	presence,in
R345	T1166	T1165	prep	of,presence
R346	T1167	T1166	pobj	Ca2+,of
R347	T1168	T1136	punct	.,is
R348	T1170	T1171	det	This,activity
R349	T1171	T1172	nsubj	activity,led
R350	T1173	T1172	prep	to,led
R351	T1174	T1175	det	the,proposal
R352	T1175	T1173	pobj	proposal,to
R353	T1176	T1175	prep	of,proposal
R354	T1177	T1178	compound	annexin,A7
R355	T1178	T1179	poss	A7,involvement
R356	T1179	T1176	pobj	involvement,of
R357	T1180	T1178	case	's,A7
R358	T1181	T1179	prep	in,involvement
R359	T1182	T1183	det	the,secretion
R360	T1183	T1181	pobj	secretion,in
R361	T1184	T1183	amod	exocytotic,secretion
R362	T1185	T1183	prep	of,secretion
R363	T1186	T1185	pobj	catecholamines,of
R364	T1187	T1188	punct	[,1
R365	T1188	T1172	parataxis	1,led
R366	T1189	T1188	punct	],1
R367	T1190	T1172	punct	.,led
R368	T1192	T1193	det	The,protein
R369	T1193	T1194	nsubj	protein,belongs
R370	T1195	T1194	prep	to,belongs
R371	T1196	T1197	det	a,family
R372	T1197	T1195	pobj	family,to
R373	T1198	T1197	prep	of,family
R374	T1199	T1200	advmod	evolutionarily,conserved
R375	T1200	T1201	amod	conserved,proteins
R376	T1201	T1198	pobj	proteins,of
R377	T1202	T1201	prep	of,proteins
R378	T1203	T1204	det	a,structure
R379	T1204	T1202	pobj	structure,of
R380	T1205	T1204	amod	bipartite,structure
R381	T1206	T1201	prep	with,proteins
R382	T1207	T1208	det	a,variable
R383	T1208	T1206	pobj	variable,with
R384	T1209	T1210	npadvmod	N,terminal
R385	T1210	T1208	amod	terminal,variable
R386	T1211	T1210	punct	-,terminal
R387	T1212	T1208	cc	and,variable
R388	T1213	T1214	det	a,conserved
R389	T1214	T1208	conj	conserved,variable
R390	T1215	T1216	npadvmod	C,terminal
R391	T1216	T1214	amod	terminal,conserved
R392	T1217	T1216	punct	-,terminal
R393	T1218	T1208	appos	domain,variable
R394	T1219	T1194	punct	.,belongs
R395	T1221	T1222	det	The,domain
R396	T1222	T1226	nsubj	domain,is
R397	T1223	T1224	npadvmod	C,terminal
R398	T1224	T1222	amod	terminal,domain
R399	T1225	T1224	punct	-,terminal
R400	T1226	T1227	ccomp	is,appears
R401	T1228	T1226	acomp	responsible,is
R402	T1229	T1228	prep	for,responsible
R403	T1230	T1231	det	the,Ca2+
R404	T1231	T1229	pobj	Ca2+,for
R405	T1232	T1231	punct	-,Ca2+
R406	T1233	T1231	cc	and,Ca2+
R407	T1234	T1231	conj	phospholipid,Ca2+
R408	T1235	T1231	punct	-,Ca2+
R409	T1236	T1231	amod	binding,Ca2+
R410	T1237	T1227	punct	", ",appears
R411	T1238	T1239	det	the,domain
R412	T1239	T1227	nsubj	domain,appears
R413	T1240	T1241	npadvmod	N,terminal
R414	T1241	T1239	amod	terminal,domain
R415	T1242	T1241	punct	-,terminal
R416	T1243	T1244	aux	to,confer
R417	T1244	T1227	xcomp	confer,appears
R418	T1245	T1246	amod	functional,diversity
R419	T1246	T1244	dobj	diversity,confer
R420	T1247	T1248	punct	[,2
R421	T1248	T1227	parataxis	2,appears
R422	T1249	T1250	punct	-,4
R423	T1250	T1248	prep	4,2
R424	T1251	T1248	punct	],2
R425	T1252	T1227	punct	.,appears
R426	T1254	T1255	det	The,binding
R427	T1255	T1256	nsubjpass	binding,thought
R428	T1257	T1255	prep	to,binding
R429	T1258	T1259	advmod	negatively,charged
R430	T1259	T1260	amod	charged,phospholipids
R431	T1260	T1257	pobj	phospholipids,to
R432	T1261	T1256	auxpass	is,thought
R433	T1262	T1263	aux	to,mediated
R434	T1263	T1256	xcomp	mediated,thought
R435	T1264	T1263	auxpass	be,mediated
R436	T1265	T1263	agent	by,mediated
R437	T1266	T1267	compound	Ca2+,ions
R438	T1267	T1265	pobj	ions,by
R439	T1268	T1256	punct	.,thought
R440	T1270	T1271	compound	Annexin,A7
R441	T1271	T1272	nsubj	A7,is
R442	T1273	T1272	acomp	unique,is
R443	T1274	T1275	mark	in,carries
R444	T1275	T1272	advcl	carries,is
R445	T1276	T1275	mark	that,carries
R446	T1277	T1275	nsubj	it,carries
R447	T1278	T1279	det	an,terminus
R448	T1279	T1275	dobj	terminus,carries
R449	T1280	T1281	advmod	extraordinarily,long
R450	T1281	T1279	amod	long,terminus
R451	T1282	T1281	cc	and,long
R452	T1283	T1281	conj	hydrophobic,long
R453	T1284	T1279	compound	amino,terminus
R454	T1285	T1279	prep	with,terminus
R455	T1286	T1287	amod	more,100
R456	T1287	T1289	nummod	100,acids
R457	T1288	T1287	quantmod	than,100
R458	T1289	T1285	pobj	acids,with
R459	T1290	T1289	compound	amino,acids
R460	T1291	T1272	punct	.,is
R461	T1293	T1294	amod	Alternative,splicing
R462	T1294	T1295	nsubj	splicing,gives
R463	T1296	T1295	dobj	rise,gives
R464	T1297	T1295	prep	to,gives
R465	T1298	T1299	nummod	two,isoforms
R466	T1299	T1297	pobj	isoforms,to
R467	T1300	T1299	prep	of,isoforms
R468	T1301	T1302	nummod	47,kDa
R469	T1302	T1300	pobj	kDa,of
R470	T1303	T1301	cc	and,47
R471	T1304	T1301	conj	51,47
R472	T1305	T1295	punct	.,gives
R473	T1307	T1308	det	Both,isoforms
R474	T1308	T1309	nsubj	isoforms,differ
R475	T1310	T1309	prep	by,differ
R476	T1311	T1312	det	an,exon
R477	T1312	T1310	pobj	exon,by
R478	T1313	T1312	amod	additional,exon
R479	T1314	T1312	compound	cassette,exon
R480	T1315	T1312	amod	located,exon
R481	T1316	T1315	prep	in,located
R482	T1317	T1318	det	the,third
R483	T1318	T1316	pobj	third,in
R484	T1319	T1318	amod	first,third
R485	T1320	T1318	prep	of,third
R486	T1321	T1322	det	the,domain
R487	T1322	T1320	pobj	domain,of
R488	T1323	T1324	npadvmod	N,terminal
R489	T1324	T1322	amod	terminal,domain
R490	T1325	T1324	punct	-,terminal
R491	T1326	T1309	punct	.,differ
R492	T1328	T1329	amod	Most,tissues
R493	T1329	T1330	nsubj	tissues,harbor
R494	T1330	T1331	ccomp	harbor,found
R495	T1332	T1333	advmod	only,isoform
R496	T1333	T1330	dobj	isoform,harbor
R497	T1334	T1333	det	the,isoform
R498	T1335	T1336	nummod	47,kDa
R499	T1336	T1333	compound	kDa,isoform
R500	T1337	T1331	punct	", ",found
R501	T1338	T1339	det	both,forms
R502	T1339	T1331	nsubjpass	forms,found
R503	T1340	T1331	auxpass	are,found
R504	T1341	T1331	prep	in,found
R505	T1342	T1341	pobj	brain,in
R506	T1343	T1342	cc	and,brain
R507	T1344	T1342	conj	heart,brain
R508	T1345	T1331	punct	", ",found
R509	T1346	T1347	prep	while,expressed
R510	T1347	T1331	advcl	expressed,found
R511	T1348	T1349	det	the,isoform
R512	T1349	T1347	nsubjpass	isoform,expressed
R513	T1350	T1349	amod	large,isoform
R514	T1351	T1347	auxpass	is,expressed
R515	T1352	T1347	advmod	exclusively,expressed
R516	T1353	T1347	prep	in,expressed
R517	T1354	T1355	amod	mature,muscle
R518	T1355	T1353	pobj	muscle,in
R519	T1356	T1355	amod	skeletal,muscle
R520	T1357	T1331	punct	.,found
R521	T1359	T1360	prep	At,detected
R522	T1361	T1362	det	the,level
R523	T1362	T1359	pobj	level,At
R524	T1363	T1362	amod	cellular,level
R525	T1364	T1365	compound	annexin,A7
R526	T1365	T1360	nsubjpass	A7,detected
R527	T1366	T1360	aux	can,detected
R528	T1367	T1360	auxpass	be,detected
R529	T1368	T1360	prep	in,detected
R530	T1369	T1370	det	the,cytosol
R531	T1370	T1368	pobj	cytosol,in
R532	T1371	T1368	punct	", ",in
R533	T1372	T1368	conj	at,in
R534	T1373	T1374	det	the,membrane
R535	T1374	T1372	pobj	membrane,at
R536	T1375	T1374	compound	plasma,membrane
R537	T1376	T1372	punct	", ",at
R538	T1377	T1372	conj	around,at
R539	T1378	T1379	det	the,nucleus
R540	T1379	T1377	pobj	nucleus,around
R541	T1380	T1377	punct	", ",around
R542	T1381	T1377	conj	at,around
R543	T1382	T1383	amod	vesicular,structures
R544	T1383	T1381	pobj	structures,at
R545	T1384	T1383	prep	including,structures
R546	T1385	T1386	amod	adrenal,granules
R547	T1386	T1384	pobj	granules,including
R548	T1387	T1386	compound	chromaffin,granules
R549	T1388	T1381	punct	", ",at
R550	T1389	T1381	cc	and,at
R551	T1390	T1381	conj	at,at
R552	T1391	T1392	det	the,system
R553	T1392	T1390	pobj	system,at
R554	T1393	T1394	compound	t,tubule
R555	T1394	T1392	compound	tubule,system
R556	T1395	T1394	punct	-,tubule
R557	T1396	T1397	punct	[,6
R558	T1397	T1360	parataxis	6,detected
R559	T1398	T1397	nummod	5,6
R560	T1399	T1397	punct	",",6
R561	T1400	T1397	punct	],6
R562	T1401	T1360	punct	.,detected
R563	T1403	T1404	compound	Annexin,A7
R564	T1404	T1405	nsubj	A7,translocates
R565	T1406	T1405	prep	to,translocates
R566	T1407	T1406	pobj	membranes,to
R567	T1408	T1405	prep	in,translocates
R568	T1409	T1410	det	a,fashion
R569	T1410	T1408	pobj	fashion,in
R570	T1411	T1412	npadvmod	Ca2+,dependent
R571	T1412	T1410	amod	dependent,fashion
R572	T1413	T1412	punct	-,dependent
R573	T1414	T1405	cc	and,translocates
R574	T1415	T1416	punct	", ",redistributes
R575	T1416	T1405	conj	redistributes,translocates
R576	T1417	T1418	advmod	when,rise
R577	T1418	T1416	advcl	rise,redistributes
R578	T1419	T1420	amod	intracellular,levels
R579	T1420	T1418	nsubj	levels,rise
R580	T1421	T1420	compound	Ca2+,levels
R581	T1422	T1416	punct	", ",redistributes
R582	T1423	T1416	advmod	sequentially,redistributes
R583	T1424	T1416	prep	to,redistributes
R584	T1425	T1426	det	the,plasma
R585	T1426	T1424	pobj	plasma,to
R586	T1427	T1426	cc	and,plasma
R587	T1428	T1429	det	the,membrane
R588	T1429	T1426	conj	membrane,plasma
R589	T1430	T1429	amod	nuclear,membrane
R590	T1431	T1432	advmod	as,as
R591	T1432	T1424	cc	as,to
R592	T1433	T1432	advmod	well,as
R593	T1434	T1424	conj	to,to
R594	T1435	T1436	amod	intracellular,vesicles
R595	T1436	T1434	pobj	vesicles,to
R596	T1437	T1405	punct	.,translocates
R597	T1439	T1440	advmod	Furthermore,associates
R598	T1441	T1440	punct	", ",associates
R599	T1442	T1443	compound	annexin,A7
R600	T1443	T1440	nsubj	A7,associates
R601	T1444	T1440	prep	with,associates
R602	T1445	T1446	compound	lipid,rafts
R603	T1446	T1444	pobj	rafts,with
R604	T1447	T1448	punct	[,7
R605	T1448	T1440	parataxis	7,associates
R606	T1449	T1448	punct	],7
R607	T1450	T1440	punct	.,associates
R608	T1452	T1453	compound	Lipid,rafts
R609	T1453	T1454	nsubj	rafts,play
R610	T1455	T1456	det	a,role
R611	T1456	T1454	dobj	role,play
R612	T1457	T1456	amod	key,role
R613	T1458	T1454	prep	in,play
R614	T1459	T1460	compound	membrane,budding
R615	T1460	T1458	pobj	budding,in
R616	T1461	T1458	cc	and,in
R617	T1462	T1458	conj	in,in
R618	T1463	T1464	compound	vesiculation,processes
R619	T1464	T1462	pobj	processes,in
R620	T1465	T1466	amod	such,as
R621	T1466	T1464	prep	as,processes
R622	T1467	T1468	nmod	endo,exocytosis
R623	T1468	T1466	pobj	exocytosis,as
R624	T1469	T1468	punct	-,exocytosis
R625	T1470	T1468	cc	and,exocytosis
R626	T1471	T1472	punct	[,8
R627	T1472	T1454	parataxis	8,play
R628	T1473	T1474	punct	-,10
R629	T1474	T1472	prep	10,8
R630	T1475	T1472	punct	],8
R631	T1476	T1454	punct	.,play
R632	T1478	T1479	nummod	Two,partners
R633	T1479	T1481	nsubjpass	partners,identified
R634	T1480	T1479	amod	binding,partners
R635	T1482	T1479	prep	of,partners
R636	T1483	T1484	compound	annexin,A7
R637	T1484	T1482	pobj	A7,of
R638	T1485	T1481	aux	have,identified
R639	T1486	T1481	auxpass	been,identified
R640	T1487	T1481	punct	", ",identified
R641	T1488	T1481	dobj	sorcin,identified
R642	T1489	T1488	cc	and,sorcin
R643	T1490	T1488	conj	galectin,sorcin
R644	T1491	T1490	punct	-,galectin
R645	T1492	T1490	nummod	3,galectin
R646	T1493	T1494	punct	[,11
R647	T1494	T1481	parataxis	11,identified
R648	T1495	T1496	punct	-,13
R649	T1496	T1494	prep	13,11
R650	T1497	T1494	punct	],11
R651	T1498	T1481	punct	.,identified
R652	T1500	T1501	nsubj	Sorcin,is
R653	T1502	T1503	det	a,protein
R654	T1503	T1501	attr	protein,is
R655	T1504	T1505	npadvmod	Ca2+,binding
R656	T1505	T1503	amod	binding,protein
R657	T1506	T1505	punct	-,binding
R658	T1507	T1501	cc	and,is
R659	T1508	T1501	conj	belongs,is
R660	T1509	T1508	prep	to,belongs
R661	T1510	T1511	det	the,family
R662	T1511	T1509	pobj	family,to
R663	T1512	T1513	compound	penta,protein
R664	T1513	T1511	compound	protein,family
R665	T1514	T1515	compound	EF,hand
R666	T1515	T1513	compound	hand,protein
R667	T1516	T1515	punct	-,hand
R668	T1517	T1518	punct	[,14
R669	T1518	T1508	parataxis	14,belongs
R670	T1519	T1518	punct	],14
R671	T1520	T1501	punct	.,is
R672	T1522	T1523	prep	Like,binds
R673	T1524	T1525	compound	annexin,A7
R674	T1525	T1522	pobj	A7,Like
R675	T1526	T1523	nsubj	it,binds
R676	T1527	T1523	prep	to,binds
R677	T1528	T1527	pobj	membranes,to
R678	T1529	T1523	prep	in,binds
R679	T1530	T1531	det	a,manner
R680	T1531	T1529	pobj	manner,in
R681	T1532	T1533	npadvmod	Ca2+,dependent
R682	T1533	T1531	amod	dependent,manner
R683	T1534	T1533	punct	-,dependent
R684	T1535	T1523	punct	.,binds
R685	T1537	T1538	nsubjpass	Sorcin,described
R686	T1539	T1538	advmod	also,described
R687	T1540	T1538	aux	has,described
R688	T1541	T1538	auxpass	been,described
R689	T1542	T1538	prep	as,described
R690	T1543	T1544	compound	interaction,partner
R691	T1544	T1542	pobj	partner,as
R692	T1545	T1544	prep	of,partner
R693	T1546	T1547	det	the,receptor
R694	T1547	T1545	pobj	receptor,of
R695	T1548	T1547	compound	ryanodine,receptor
R696	T1549	T1538	punct	", ",described
R697	T1550	T1538	cc	and,described
R698	T1551	T1538	conj	appears,described
R699	T1552	T1553	aux	to,modulate
R700	T1553	T1551	xcomp	modulate,appears
R701	T1554	T1555	poss	its,function
R702	T1555	T1553	dobj	function,modulate
R703	T1556	T1557	punct	[,15
R704	T1557	T1551	parataxis	15,appears
R705	T1558	T1557	punct	],15
R706	T1559	T1538	punct	.,described
R707	T1561	T1562	det	The,influence
R708	T1562	T1563	nsubj	influence,is
R709	T1564	T1562	prep	of,influence
R710	T1565	T1566	det	the,interaction
R711	T1566	T1564	pobj	interaction,of
R712	T1567	T1568	compound	sorcin,annexin
R713	T1568	T1570	compound	annexin,A7
R714	T1569	T1568	punct	/,annexin
R715	T1570	T1566	compound	A7,interaction
R716	T1571	T1562	prep	on,influence
R717	T1572	T1573	det	the,receptor
R718	T1573	T1571	pobj	receptor,on
R719	T1574	T1573	compound	ryanodine,receptor
R720	T1575	T1563	acomp	unknown,is
R721	T1576	T1563	punct	.,is
R722	T1578	T1579	nsubjpass	Sorcin,coexpressed
R723	T1580	T1578	cc	and,Sorcin
R724	T1581	T1582	compound	annexin,A7
R725	T1582	T1578	conj	A7,Sorcin
R726	T1583	T1579	auxpass	are,coexpressed
R727	T1584	T1579	prep	in,coexpressed
R728	T1585	T1586	det	all,tissues
R729	T1586	T1584	pobj	tissues,in
R730	T1587	T1586	acl	examined,tissues
R731	T1588	T1589	advmod	so,far
R732	T1589	T1587	advmod	far,examined
R733	T1590	T1591	punct	[,11
R734	T1591	T1579	parataxis	11,coexpressed
R735	T1592	T1591	punct	],11
R736	T1593	T1579	punct	.,coexpressed
R737	T1595	T1596	det	The,binding
R738	T1596	T1597	nsubj	binding,is
R739	T1598	T1596	prep	of,binding
R740	T1599	T1600	compound	annexin,A7
R741	T1600	T1598	pobj	A7,of
R742	T1601	T1600	cc	and,A7
R743	T1602	T1600	conj	sorcin,A7
R744	T1603	T1604	npadvmod	Ca2+,dependent
R745	T1604	T1597	acomp	dependent,is
R746	T1605	T1604	punct	-,dependent
R747	T1606	T1597	cc	and,is
R748	T1607	T1597	conj	occurs,is
R749	T1608	T1607	prep	at,occurs
R750	T1609	T1610	amod	micromolar,Ca2+
R751	T1610	T1611	compound	Ca2+,concentrations
R752	T1611	T1608	pobj	concentrations,at
R753	T1612	T1597	punct	.,is
R754	T1614	T1615	det	The,sites
R755	T1615	T1617	nsubjpass	sites,localised
R756	T1616	T1615	amod	binding,sites
R757	T1618	T1617	aux	have,localised
R758	T1619	T1617	auxpass	been,localised
R759	T1620	T1617	prep	to,localised
R760	T1621	T1622	det	the,motifs
R761	T1622	T1620	pobj	motifs,to
R762	T1623	T1624	npadvmod	amino,terminal
R763	T1624	T1622	amod	terminal,motifs
R764	T1625	T1622	nmod	GGYY,motifs
R765	T1626	T1625	cc	and,GGYY
R766	T1627	T1625	conj	GYGG,GGYY
R767	T1628	T1622	prep	in,motifs
R768	T1629	T1628	pobj	sorcin,in
R769	T1630	T1620	cc	and,to
R770	T1631	T1620	conj	to,to
R771	T1632	T1633	det	the,motif
R772	T1633	T1631	pobj	motif,to
R773	T1634	T1633	compound	GYPP,motif
R774	T1635	T1633	prep	in,motif
R775	T1636	T1637	det	the,terminus
R776	T1637	T1635	pobj	terminus,in
R777	T1638	T1637	compound	amino,terminus
R778	T1639	T1637	prep	of,terminus
R779	T1640	T1641	compound	annexin,A7
R780	T1641	T1639	pobj	A7,of
R781	T1642	T1617	punct	.,localised
R782	T1644	T1645	det	The,proteins
R783	T1645	T1646	nsubj	proteins,bind
R784	T1647	T1646	prep	to,bind
R785	T1648	T1649	det	each,other
R786	T1649	T1647	pobj	other,to
R787	T1650	T1646	prep	with,bind
R788	T1651	T1652	det	a,stoichiometry
R789	T1652	T1650	pobj	stoichiometry,with
R790	T1653	T1652	prep	of,stoichiometry
R791	T1654	T1655	nummod	two,molecules
R792	T1655	T1653	pobj	molecules,of
R793	T1656	T1655	compound	sorcin,molecules
R794	T1657	T1655	prep	per,molecules
R795	T1658	T1659	compound	annexin,A7
R796	T1659	T1660	compound	A7,molecule
R797	T1660	T1657	pobj	molecule,per
R798	T1661	T1662	punct	[,12
R799	T1662	T1646	parataxis	12,bind
R800	T1663	T1662	punct	],12
R801	T1664	T1646	punct	.,bind
R802	T1666	T1667	nsubj	Galectin,is
R803	T1668	T1666	punct	-,Galectin
R804	T1669	T1666	nummod	3,Galectin
R805	T1670	T1671	det	a,protein
R806	T1671	T1667	attr	protein,is
R807	T1672	T1671	amod	multifunctional,protein
R808	T1673	T1671	amod	oncogenic,protein
R809	T1674	T1671	prep	with,protein
R810	T1675	T1676	det	an,activity
R811	T1676	T1674	pobj	activity,with
R812	T1677	T1676	amod	anti-apoptotic,activity
R813	T1678	T1671	acl	found,protein
R814	T1679	T1678	prep	in,found
R815	T1680	T1681	det	the,space
R816	T1681	T1679	pobj	space,in
R817	T1682	T1681	amod	extracellular,space
R818	T1683	T1681	punct	", ",space
R819	T1684	T1681	prep	in,space
R820	T1685	T1686	det	the,nucleus
R821	T1686	T1684	pobj	nucleus,in
R822	T1687	T1686	cc	and,nucleus
R823	T1688	T1686	conj	cytoplasm,nucleus
R824	T1689	T1679	cc	and,in
R825	T1690	T1679	conj	in,in
R826	T1691	T1690	pobj	mitochondria,in
R827	T1692	T1667	punct	.,is
R828	T1694	T1695	amod	Cytoplasmic,galectin
R829	T1695	T1696	nsubj	galectin,correlates
R830	T1697	T1695	punct	-,galectin
R831	T1698	T1695	nummod	3,galectin
R832	T1699	T1696	prep	with,correlates
R833	T1700	T1701	compound	tumor,progression
R834	T1701	T1699	pobj	progression,with
R835	T1702	T1696	cc	and,correlates
R836	T1703	T1696	conj	protects,correlates
R837	T1704	T1705	amod	mitochondrial,integrity
R838	T1705	T1703	dobj	integrity,protects
R839	T1706	T1696	punct	.,correlates
R840	T1708	T1709	compound	Down,regulation
R841	T1709	T1710	nsubj	regulation,prevents
R842	T1711	T1709	prep	of,regulation
R843	T1712	T1713	compound	annexin,A7
R844	T1713	T1711	pobj	A7,of
R845	T1714	T1715	compound	galectin,3
R846	T1715	T1717	compound	3,translocation
R847	T1716	T1715	punct	-,3
R848	T1717	T1710	dobj	translocation,prevents
R849	T1718	T1717	prep	to,translocation
R850	T1719	T1720	det	the,membrane
R851	T1720	T1718	pobj	membrane,to
R852	T1721	T1720	amod	perinuclear,membrane
R853	T1722	T1710	cc	and,prevents
R854	T1723	T1710	conj	increases,prevents
R855	T1724	T1725	compound	galectin,3
R856	T1725	T1727	compound	3,secretion
R857	T1726	T1725	punct	-,3
R858	T1727	T1723	dobj	secretion,increases
R859	T1728	T1710	punct	.,prevents
R860	T1730	T1731	prep	For,proposed
R861	T1732	T1733	compound	annexin,A7
R862	T1733	T1730	pobj	A7,For
R863	T1734	T1735	det	a,role
R864	T1735	T1731	nsubjpass	role,proposed
R865	T1736	T1735	prep	for,role
R866	T1737	T1738	compound	galectin,3
R867	T1738	T1740	compound	3,trafficking
R868	T1739	T1738	punct	-,3
R869	T1740	T1736	pobj	trafficking,for
R870	T1741	T1740	punct	", ",trafficking
R871	T1742	T1743	compound	apoptosis,regulation
R872	T1743	T1740	conj	regulation,trafficking
R873	T1744	T1743	punct	", ",regulation
R874	T1745	T1743	cc	and,regulation
R875	T1746	T1747	amod	mitochondrial,integrity
R876	T1747	T1743	conj	integrity,regulation
R877	T1748	T1731	auxpass	was,proposed
R878	T1749	T1750	punct	[,13
R879	T1750	T1731	parataxis	13,proposed
R880	T1751	T1750	punct	],13
R881	T1752	T1731	punct	.,proposed
R882	T1754	T1755	det	The,role
R883	T1755	T1757	nsubjpass	role,understood
R884	T1756	T1755	amod	cellular,role
R885	T1758	T1755	prep	of,role
R886	T1759	T1760	compound	annexin,A7
R887	T1760	T1758	pobj	A7,of
R888	T1761	T1757	auxpass	is,understood
R889	T1762	T1757	neg	not,understood
R890	T1763	T1757	advmod	well,understood
R891	T1764	T1757	punct	.,understood
R892	T1766	T1767	nsubjpass	It,thought
R893	T1768	T1767	auxpass	is,thought
R894	T1769	T1770	aux	to,regulate
R895	T1770	T1767	xcomp	regulate,thought
R896	T1771	T1770	cc	and,regulate
R897	T1772	T1770	conj	stabilize,regulate
R898	T1773	T1774	compound	membrane,domains
R899	T1774	T1772	dobj	domains,stabilize
R900	T1775	T1770	cc	and,regulate
R901	T1776	T1777	aux	to,have
R902	T1777	T1770	conj	have,regulate
R903	T1778	T1779	det	a,role
R904	T1779	T1777	dobj	role,have
R905	T1780	T1777	prep	in,have
R906	T1781	T1782	compound	Ca2+,homeostasis
R907	T1782	T1780	pobj	homeostasis,in
R908	T1783	T1782	cc	and,homeostasis
R909	T1784	T1785	npadvmod	Ca2+,dependent
R910	T1785	T1787	amod	dependent,pathways
R911	T1786	T1785	punct	-,dependent
R912	T1787	T1782	conj	pathways,homeostasis
R913	T1788	T1787	compound	signaling,pathways
R914	T1789	T1767	punct	.,thought
R915	T1791	T1792	det	These,proposals
R916	T1792	T1793	nsubjpass	proposals,supported
R917	T1794	T1793	auxpass	are,supported
R918	T1795	T1793	agent	by,supported
R919	T1796	T1795	pobj	data,by
R920	T1797	T1796	acl	obtained,data
R921	T1798	T1797	prep	from,obtained
R922	T1799	T1798	pobj	analysis,from
R923	T1800	T1799	prep	of,analysis
R924	T1801	T1802	compound	annexin,A7
R925	T1802	T1803	npadvmod	A7,deficient
R926	T1803	T1804	amod	deficient,mutants
R927	T1804	T1800	pobj	mutants,of
R928	T1805	T1804	compound	mouse,mutants
R929	T1806	T1793	punct	.,supported
R930	T1808	T1809	nummod	Two,strains
R931	T1809	T1815	nsubjpass	strains,generated
R932	T1810	T1811	nmod	annexin,A7
R933	T1811	T1809	nmod	A7,strains
R934	T1812	T1809	nmod	129Sv,strains
R935	T1919	T1917	cc	and,cells
R936	T1813	T1809	amod	null,strains
R937	T1920	T1917	conj	platelets,cells
R938	T1814	T1809	compound	mice,strains
R939	T1921	T1914	auxpass	were,thought
R940	T1816	T1815	auxpass	were,generated
R941	T1817	T1815	advmod	independently,generated
R942	T1922	T1914	neg	not,thought
R943	T1818	T1815	advcl	using,generated
R944	T1819	T1820	det	a,strategy
R945	T1923	T1924	aux	to,contain
R946	T1820	T1818	dobj	strategy,using
R947	T1821	T1820	amod	different,strategy
R948	T1924	T1914	xcomp	contain,thought
R949	T1822	T1815	punct	.,generated
R950	T1824	T1825	det	The,one
R951	T1925	T1926	compound	annexin,A7
R952	T1825	T1826	nsubj	one,is
R953	T1926	T1924	dobj	A7,contain
R954	T1927	T1914	cc	and,thought
R955	T1928	T1929	advmod	only,recently
R956	T1827	T1825	prep	of,one
R957	T1929	T1930	advmod	recently,reported
R958	T1828	T1827	pobj	Srivastava,of
R959	T1829	T1830	advmod	et,al.
R960	T1830	T1828	advmod	al.,Srivastava
R961	T1930	T1914	conj	reported,thought
R962	T1831	T1832	punct	[,16
R963	T1832	T1828	parataxis	16,Srivastava
R964	T1931	T1932	det	the,isoform
R965	T1833	T1832	punct	],16
R966	T1834	T1826	acomp	lethal,is
R967	T1835	T1826	punct	.,is
R968	T1932	T1930	nsubjpass	isoform,reported
R969	T1837	T1838	amod	Heterozygous,mice
R970	T1933	T1934	nummod	47,kDa
R971	T1838	T1839	nsubj	mice,exhibit
R972	T1934	T1932	compound	kDa,isoform
R973	T1840	T1841	det	an,defect
R974	T1841	T1839	dobj	defect,exhibit
R975	T1842	T1843	compound	insulin,secretion
R976	T1935	T1930	aux	has,reported
R977	T1843	T1841	compound	secretion,defect
R978	T1844	T1841	cc	and,defect
R979	T1845	T1846	compound	tumor,phenotypes
R980	T1936	T1930	auxpass	been,reported
R981	T1846	T1841	conj	phenotypes,defect
R982	T1847	T1839	punct	.,exhibit
R983	T1937	T1930	prep	as,reported
R984	T1849	T1850	det	The,strain
R985	T1850	T1852	nsubj	strain,is
R986	T1851	T1850	amod	null,strain
R987	T1853	T1850	acl	reported,strain
R988	T1938	T1937	pobj	component,as
R989	T1854	T1853	agent	by,reported
R990	T1855	T1854	pobj	Herr,by
R991	T1939	T1938	prep	of,component
R992	T1856	T1857	advmod	et,al.
R993	T1857	T1855	advmod	al.,Herr
R994	T1858	T1859	punct	[,17
R995	T1940	T1941	amod	red,cells
R996	T1859	T1853	parataxis	17,reported
R997	T1860	T1859	punct	],17
R998	T1941	T1939	pobj	cells,of
R999	T1861	T1862	amod	viable,healthy
R1000	T1862	T1852	acomp	healthy,is
R1001	T1863	T1862	punct	", ",healthy
R1002	T1942	T1941	compound	blood,cells
R1003	T1864	T1852	punct	", ",is
R1004	T1865	T1852	cc	and,is
R1005	T1943	T1944	punct	[,7
R1006	T1866	T1852	conj	shows,is
R1007	T1867	T1868	det	no,defect
R1008	T1868	T1866	dobj	defect,shows
R1009	T1944	T1930	parataxis	7,reported
R1010	T1869	T1870	compound	insulin,secretion
R1011	T1870	T1868	compound	secretion,defect
R1012	T1945	T1944	punct	],7
R1013	T1871	T1868	cc	or,defect
R1014	T1946	T1914	punct	.,thought
R1015	T1872	T1873	amod	other,defects
R1016	T1948	T1949	amod	Red,cells
R1017	T1873	T1868	conj	defects,defect
R1018	T1874	T1873	amod	obvious,defects
R1019	T1875	T1852	punct	.,is
R1020	T1949	T1951	nsubj	cells,undergo
R1021	T1877	T1878	advmod	However,disturbed
R1022	T1950	T1949	compound	blood,cells
R1023	T1879	T1878	punct	", ",disturbed
R1024	T1880	T1878	prep	in,disturbed
R1025	T1952	T1953	amod	various,changes
R1026	T1881	T1882	amod	isolated,cardiomyocytes
R1027	T1882	T1880	pobj	cardiomyocytes,in
R1028	T1883	T1884	det	the,shortening
R1029	T1953	T1951	dobj	changes,undergo
R1030	T1884	T1878	nsubjpass	shortening,disturbed
R1031	T1885	T1886	npadvmod	frequency,induced
R1032	T1954	T1953	amod	biochemical,changes
R1033	T1886	T1884	amod	induced,shortening
R1034	T1887	T1886	punct	-,induced
R1035	T1888	T1878	auxpass	is,disturbed
R1036	T1889	T1878	punct	.,disturbed
R1037	T1955	T1954	cc	or,biochemical
R1038	T1891	T1892	advmod	Here,focused
R1039	T1956	T1954	conj	morphological,biochemical
R1040	T1893	T1892	nsubj	we,focused
R1041	T1957	T1958	dep	that,appear
R1042	T1894	T1892	aux	have,focused
R1043	T1895	T1892	prep	on,focused
R1044	T1896	T1897	det	the,analysis
R1045	T1958	T1953	relcl	appear,changes
R1046	T1897	T1895	pobj	analysis,on
R1047	T1898	T1897	prep	of,analysis
R1048	T1959	T1960	aux	to,be
R1049	T1899	T1900	amod	red,cells
R1050	T1900	T1898	pobj	cells,of
R1051	T1901	T1900	compound	blood,cells
R1052	T1960	T1958	xcomp	be,appear
R1053	T1902	T1900	cc	and,cells
R1054	T1903	T1900	conj	platelets,cells
R1055	T1904	T1900	prep	of,cells
R1056	T1961	T1962	npadvmod	Ca2+,dependent
R1057	T1905	T1906	det	the,mutant
R1058	T1906	T1904	pobj	mutant,of
R1059	T1907	T1906	nmod	anxA7,mutant
R1060	T1962	T1964	amod	dependent,processes
R1061	T1908	T1907	punct	-,anxA7
R1062	T1909	T1907	punct	/,anxA7
R1063	T1963	T1962	punct	-,dependent
R1064	T1910	T1907	punct	-,anxA7
R1065	T1911	T1892	punct	.,focused
R1066	T1964	T1960	attr	processes,be
R1067	T1913	T1914	advmod	Generally,thought
R1068	T1915	T1914	punct	", ",thought
R1069	T1965	T1966	punct	[,19
R1070	T1916	T1917	amod	red,cells
R1071	T1917	T1914	nsubjpass	cells,thought
R1072	T1966	T1951	parataxis	19,undergo
R1073	T1918	T1917	compound	blood,cells
R1074	T1967	T1966	nummod	18,19
R1075	T1968	T1966	punct	",",19
R1076	T1969	T1966	punct	],19
R1077	T1970	T1951	punct	.,undergo
R1078	T1972	T1973	nsubj	One,is
R1079	T2026	T2027	dep	which,lack
R1080	T2027	T2023	relcl	lack,cells
R1081	T1974	T1972	prep	of,One
R1082	T2028	T2029	det	the,ability
R1083	T2029	T2027	dobj	ability,lack
R1084	T2030	T2031	aux	to,vesiculate
R1085	T1975	T1974	pobj	them,of
R1086	T2031	T2029	acl	vesiculate,ability
R1087	T2032	T2033	det	a,disease
R1088	T2033	T2025	dobj	disease,cause
R1089	T2034	T2025	prep	with,cause
R1090	T2035	T2036	amod	red,cell
R1091	T2036	T2038	compound	cell,destruction
R1092	T1976	T1977	det	the,release
R1093	T2037	T2036	compound	blood,cell
R1094	T2038	T2034	pobj	destruction,with
R1095	T2039	T2038	cc	and,destruction
R1096	T1977	T1973	attr	release,is
R1097	T2040	T2038	conj	haemoglobinuria,destruction
R1098	T2041	T2042	punct	[,21
R1099	T1978	T1977	prep	of,release
R1100	T2042	T2025	parataxis	21,cause
R1101	T2043	T2042	punct	],21
R1102	T1979	T1980	npadvmod	hemoglobin,containing
R1103	T2044	T2025	punct	.,cause
R1104	T2046	T2047	expl	There,exist
R1105	T1980	T1982	amod	containing,exovesicles
R1106	T2048	T2049	nummod	two,types
R1107	T2049	T2047	dobj	types,exist
R1108	T1981	T1980	punct	-,containing
R1109	T1982	T1978	pobj	exovesicles,of
R1110	T2050	T2049	prep	of,types
R1111	T2051	T2050	pobj	vesicles,of
R1112	T1983	T1977	acl	occurring,release
R1113	T2052	T2049	punct	", ",types
R1114	T2053	T2054	nmod	micro,nanovesicles
R1115	T1984	T1985	advmod	in,vivo
R1116	T2054	T2049	appos	nanovesicles,types
R1117	T2055	T2054	punct	-,nanovesicles
R1118	T2056	T2054	cc	and,nanovesicles
R1119	T1985	T1983	advmod	vivo,occurring
R1120	T2057	T2049	prep	with,types
R1121	T2058	T2059	det	a,size
R1122	T1986	T1987	advmod	as,as
R1123	T2059	T2057	pobj	size,with
R1124	T2060	T2059	prep	of,size
R1125	T1987	T1985	cc	as,vivo
R1126	T2061	T2062	nummod	180,nm
R1127	T2062	T2060	pobj	nm,of
R1128	T2063	T2062	cc	and,nm
R1129	T1988	T1987	advmod	well,as
R1130	T2064	T2065	nummod	60,nm
R1131	T2065	T2062	conj	nm,nm
R1132	T1989	T1990	advmod	in,vitro
R1133	T2066	T2047	punct	", ",exist
R1134	T2067	T2047	advmod	respectively,exist
R1135	T2068	T2047	punct	.,exist
R1136	T1990	T1985	conj	vitro,vivo
R1137	T2070	T2071	nsubjpass	They,enriched
R1138	T1991	T1992	punct	[,20
R1139	T2072	T2071	auxpass	are,enriched
R1140	T2073	T2071	prep	in,enriched
R1141	T2074	T2075	npadvmod	cholesterol,rich
R1142	T2075	T2078	amod	rich,domains
R1143	T2076	T2074	cc	and,cholesterol
R1144	T1992	T1973	parataxis	20,is
R1145	T2077	T2074	conj	sphingolipid,cholesterol
R1146	T2078	T2073	pobj	domains,in
R1147	T2079	T2080	compound	lipid,raft
R1148	T1993	T1992	nummod	7,20
R1149	T2080	T2078	compound	raft,domains
R1150	T2081	T2082	dep	that,associated
R1151	T2082	T2078	relcl	associated,domains
R1152	T1994	T1992	punct	",",20
R1153	T2083	T2082	auxpass	are,associated
R1154	T2084	T2082	prep	with,associated
R1155	T1995	T1992	punct	],20
R1156	T2085	T2084	pobj	proteins,with
R1157	T2086	T2085	prep	like,proteins
R1158	T1996	T1973	punct	.,is
R1159	T2087	T2086	pobj	acetylcholinesterase,like
R1160	T2088	T2087	punct	", ",acetylcholinesterase
R1161	T2089	T2090	compound	cell,proteins
R1162	T1998	T1999	det	This,process
R1163	T2090	T2087	conj	proteins,acetylcholinesterase
R1164	T2091	T2090	compound	surface,proteins
R1165	T2092	T2090	prep	including,proteins
R1166	T1999	T2000	nsubjpass	process,thought
R1167	T2093	T2094	det	a,receptor
R1168	T2094	T2092	pobj	receptor,including
R1169	T2095	T2094	compound	complement,receptor
R1170	T2001	T2000	auxpass	is,thought
R1171	T2096	T2090	punct	", ",proteins
R1172	T2097	T2090	cc	and,proteins
R1173	T2098	T2099	det	the,proteins
R1174	T2099	T2090	conj	proteins,proteins
R1175	T2002	T2003	aux	to,represent
R1176	T2100	T2101	compound	lipid,raft
R1177	T2101	T2099	compound	raft,proteins
R1178	T2102	T2099	appos	stomatin,proteins
R1179	T2003	T2000	xcomp	represent,thought
R1180	T2103	T2102	cc	and,stomatin
R1181	T2104	T2102	conj	flotillin,stomatin
R1182	T2105	T2071	punct	", ",enriched
R1183	T2004	T2005	det	a,method
R1184	T2106	T2071	cc	but,enriched
R1185	T2107	T2108	nsubj	they,lack
R1186	T2005	T2003	dobj	method,represent
R1187	T2108	T2071	conj	lack,enriched
R1188	T2109	T2110	det	any,protein
R1189	T2006	T2005	amod	protective,method
R1190	T2110	T2108	dobj	protein,lack
R1191	T2111	T2110	amod	cytoskeletal,protein
R1192	T2112	T2113	punct	[,7
R1193	T2113	T2108	parataxis	7,lack
R1194	T2114	T2113	punct	],7
R1195	T2115	T2108	punct	.,lack
R1196	T2007	T2005	prep	of,method
R1197	T2117	T2118	advmod	Furthermore,contain
R1198	T2008	T2009	det	the,cell
R1199	T2119	T2118	punct	", ",contain
R1200	T2120	T2118	nsubj	they,contain
R1201	T2009	T2007	pobj	cell,of
R1202	T2121	T2118	dobj	sorcin,contain
R1203	T2122	T2121	cc	and,sorcin
R1204	T2010	T2009	amod	red,cell
R1205	T2123	T2124	compound	annexin,A7
R1206	T2124	T2121	conj	A7,sorcin
R1207	T2125	T2121	acl	attached,sorcin
R1208	T2011	T2009	compound	blood,cell
R1209	T2012	T2005	prep	against,method
R1210	T2126	T2125	prep	to,attached
R1211	T2013	T2014	det	an,attack
R1212	T2127	T2128	det	the,rafts
R1213	T2128	T2126	pobj	rafts,to
R1214	T2014	T2012	pobj	attack,against
R1216	T2130	T2118	punct	.,contain
R1217	T2015	T2014	prep	by,attack
R1218	T2016	T2017	prep	for,components
R1219	T2017	T2015	pobj	components,by
R1220	T2132	T2133	det	Both,proteins
R1221	T2133	T2134	nsubj	proteins,are
R1222	T2018	T2016	pobj	example,for
R1223	T2135	T2136	advmod	more,abundant
R1224	T2136	T2134	acomp	abundant,are
R1225	T2019	T2017	compound	complement,components
R1226	T2020	T2000	punct	.,thought
R1227	T2137	T2134	prep	in,are
R1228	T2138	T2137	pobj	nanovesicles,in
R1229	T2022	T2023	amod	Red,cells
R1230	T2139	T2134	punct	.,are
R1231	T2141	T2142	det	The,formation
R1232	T2142	T2144	nsubj	formation,goes
R1233	T2023	T2025	nsubj	cells,cause
R1234	T2143	T2142	compound	vesicle,formation
R1235	T2024	T2023	compound	blood,cells
R1236	T2145	T2144	prt	along,goes
R1237	T2146	T2144	prep	with,goes
R1238	T2147	T2148	amod	several,changes
R1239	T2148	T2146	pobj	changes,with
R1240	T2149	T2148	amod	other,changes
R1241	T2150	T2148	prep	in,changes
R1242	T2151	T2152	det	the,cell
R1243	T2152	T2150	pobj	cell,in
R1244	T2153	T2152	amod	red,cell
R1245	T2154	T2152	compound	blood,cell
R1246	T2155	T2148	prep	like,changes
R1247	T2156	T2157	amod	cytoskeletal,rearrangements
R1248	T2157	T2155	pobj	rearrangements,like
R1249	T2158	T2157	cc	and,rearrangements
R1250	T2159	T2157	conj	changes,rearrangements
R1251	T2160	T2159	prep	in,changes
R1252	T2161	T2162	det	the,orientation
R1253	T2162	T2160	pobj	orientation,in
R1254	T2163	T2162	compound	phospholipid,orientation
R1255	T2164	T2159	prep	in,changes
R1256	T2165	T2166	det	the,membrane
R1257	T2166	T2164	pobj	membrane,in
R1258	T2167	T2166	amod	cellular,membrane
R1259	T2168	T2144	punct	.,goes
R1264	T2443	T2444	compound	Annexin,A7
R1265	T2444	T2445	compound	A7,expression
R1266	T2446	T2445	prep	in,expression
R1267	T2447	T2448	amod	red,cells
R1268	T2448	T2446	pobj	cells,in
R1269	T2449	T2448	compound	blood,cells
R1270	T2450	T2448	punct	", ",cells
R1271	T2451	T2452	amod	red,cell
R1272	T2452	T2454	npadvmod	cell,derived
R1273	T2453	T2452	compound	blood,cell
R1274	T2454	T2455	amod	derived,exovesicles
R1275	T2455	T2448	appos	exovesicles,cells
R1276	T2456	T2446	cc	and,in
R1277	T2457	T2446	conj	in,in
R1278	T2458	T2457	pobj	platelets,in
R1279	T2460	T2461	nsubj	Salzer,reported
R1280	T2462	T2463	advmod	et,al.
R1281	T2463	T2460	advmod	al.,Salzer
R1282	T2464	T2461	advmod	recently,reported
R1283	T2465	T2466	det	the,presence
R1284	T2466	T2461	dobj	presence,reported
R1285	T2467	T2466	prep	of,presence
R1286	T2468	T2469	det	the,isoform
R1287	T2469	T2467	pobj	isoform,of
R1288	T2470	T2471	nummod	47,kDa
R1289	T2471	T2469	compound	kDa,isoform
R1290	T2472	T2469	prep	of,isoform
R1291	T2473	T2474	compound	annexin,A7
R1292	T2474	T2472	pobj	A7,of
R1293	T2475	T2474	cc	and,A7
R1294	T2476	T2477	poss	its,partner
R1295	T2477	T2474	conj	partner,A7
R1296	T2478	T2477	appos	sorcin,partner
R1297	T2479	T2469	prep	in,isoform
R1298	T2480	T2479	pobj	micro,in
R1299	T2481	T2480	punct	-,micro
R1300	T2482	T2480	cc	and,micro
R1301	T2483	T2480	conj	nanovesicles,micro
R1302	T2484	T2480	acl	derived,micro
R1303	T2485	T2484	prep	from,derived
R1304	T2486	T2487	amod	red,cells
R1305	T2487	T2485	pobj	cells,from
R1306	T2488	T2487	compound	blood,cells
R1307	T2489	T2490	advmod	where,located
R1308	T2490	T2487	relcl	located,cells
R1309	T2491	T2490	nsubjpass	they,located
R1310	T2492	T2490	auxpass	are,located
R1311	T2493	T2490	prep	in,located
R1312	T2494	T2495	det	the,lumen
R1313	T2495	T2493	pobj	lumen,in
R1314	T2496	T2490	cc	and,located
R1315	T2497	T2498	auxpass	are,enriched
R1316	T2498	T2490	conj	enriched,located
R1317	T2499	T2498	advmod	also,enriched
R1318	T2500	T2498	prep	in,enriched
R1319	T2501	T2502	compound	membrane,rafts
R1320	T2502	T2500	pobj	rafts,in
R1321	T2503	T2504	punct	[,7
R1322	T2504	T2461	parataxis	7,reported
R1323	T2505	T2504	punct	],7
R1324	T2506	T2461	punct	.,reported
R1325	T2508	T2509	nsubj	We,extended
R1326	T2510	T2509	aux	have,extended
R1327	T2511	T2509	advmod	now,extended
R1335	T2519	T2520	det	the,isoform
R1336	T2520	T2518	nsubj	isoform,is
R1337	T2521	T2522	nummod	51,kDa
R1338	T2522	T2520	compound	kDa,isoform
R1339	T2523	T2518	acomp	present,is
R1340	T2524	T2525	advmod	as,well
R1341	T2525	T2518	advmod	well,is
R1342	T2526	T2509	punct	.,extended
R1343	T2528	T2529	prep	In,detected
R1344	T2530	T2531	amod	western,blots
R1345	T2531	T2528	pobj	blots,In
R1346	T2532	T2531	prep	of,blots
R1347	T2533	T2534	amod	human,cells
R1348	T2534	T2532	pobj	cells,of
R1349	T2535	T2534	amod	red,cells
R1350	T2536	T2534	compound	blood,cells
R1351	T2537	T2538	det	the,isoforms
R1352	T2538	T2529	nsubjpass	isoforms,detected
R1353	T2539	T2540	nummod	47,kDa
R1354	T2540	T2538	compound	kDa,isoforms
R1355	T2541	T2539	cc	and,47
R1356	T2542	T2539	conj	51,47
R1357	T2543	T2529	auxpass	were,detected
R1358	T2544	T2529	advcl	using,detected
R1359	T2545	T2544	dobj	mAb,using
R1360	T2546	T2545	nummod	203–217,mAb
R1361	T2547	T2548	punct	(,Fig.
R1362	T2548	T2529	parataxis	Fig.,detected
R1363	T2549	T2548	nummod	1,Fig.
R1364	T2550	T2548	punct	),Fig.
R1365	T2551	T2529	punct	.,detected
R1366	T2553	T2554	det	The,isoform
R1367	T2554	T2557	nsubjpass	isoform,detected
R1368	T2555	T2556	nummod	47,kDa
R1369	T2556	T2554	compound	kDa,isoform
R1370	T2558	T2557	auxpass	was,detected
R1371	T2559	T2557	prep	in,detected
R1372	T2560	T2561	npadvmod	silver,stained
R1373	T2561	T2562	amod	stained,gels
R1374	T2562	T2559	pobj	gels,in
R1375	T2563	T2557	cc	and,detected
R1376	T2564	T2565	poss	its,identity
R1377	T2565	T2566	nsubj	identity,confirmed
R1378	T2566	T2557	conj	confirmed,detected
R1379	T2567	T2565	prep	with,identity
R1380	T2568	T2569	compound	annexin,A7
R1381	T2569	T2567	pobj	A7,with
R1382	T2570	T2566	prep	by,confirmed
R1383	T2571	T2572	compound	peptide,fingerprinting
R1384	T2572	T2570	pobj	fingerprinting,by
R1385	T2573	T2572	compound	mass,fingerprinting
R1386	T2574	T2575	punct	(,shown
R1387	T2575	T2566	parataxis	shown,confirmed
R1388	T2576	T2575	nsubj	data,shown
R1389	T2577	T2575	neg	not,shown
R1390	T2578	T2575	punct	),shown
R1391	T2579	T2566	punct	.,confirmed
R1392	T2581	T2582	det	The,isoform
R1393	T2582	T2585	nsubjpass	isoform,detected
R1394	T2583	T2584	nummod	51,kDa
R1395	T2584	T2582	compound	kDa,isoform
R1396	T2586	T2585	auxpass	was,detected
R1397	T2587	T2585	advmod	only,detected
R1398	T2588	T2585	prep	in,detected
R1399	T2589	T2590	amod	western,blots
R1400	T2590	T2588	pobj	blots,in
R1401	T2591	T2585	punct	.,detected
R1420	T2613	T2614	det	a,role
R1421	T2614	T2604	dobj	role,plays
R1422	T2615	T2604	prep	in,plays
R1423	T2616	T2617	compound	membrane,organization
R1424	T2617	T2615	pobj	organization,in
R1425	T2618	T2617	cc	and,organization
R1426	T2619	T2620	det	the,process
R1427	T2620	T2617	conj	process,organization
R1428	T2621	T2620	compound	vesiculation,process
R1429	T2622	T2596	punct	.,led
R1430	T2624	T2625	aux	To,examine
R1431	T2625	T2626	advcl	examine,analysed
R1432	T2627	T2625	dobj	this,examine
R1433	T2628	T2626	punct	", ",analysed
R1434	T2629	T2626	nsubj	we,analysed
R1435	T2630	T2631	det	the,ability
R1436	T2631	T2626	dobj	ability,analysed
R1437	T2632	T2631	prep	of,ability
R1438	T2633	T2634	amod	red,cells
R1439	T2634	T2632	pobj	cells,of
R1440	T2635	T2634	compound	blood,cells
R1441	T2636	T2634	acl	derived,cells
R1442	T2637	T2636	prep	from,derived
R1443	T2638	T2639	det	the,mice
R1444	T2639	T2637	pobj	mice,from
R1445	T2640	T2641	compound	annexin,A7
R1446	T2641	T2639	compound	A7,mice
R1447	T2642	T2643	compound	knock,out
R1448	T2643	T2639	compound	out,mice
R1449	T2644	T2645	punct	(,anxA7
R1450	T2645	T2639	parataxis	anxA7,mice
R1451	T2646	T2645	punct	-,anxA7
R1452	T2647	T2645	punct	/,anxA7
R1453	T2648	T2645	punct	-,anxA7
R1454	T2649	T2645	punct	),anxA7
R1455	T2650	T2651	aux	to,form
R1456	T2651	T2631	acl	form,ability
R1457	T2652	T2651	dobj	exovesicles,form
R1458	T2653	T2626	punct	.,analysed
R1459	T2655	T2656	prep	Because,included
R1460	T2657	T2655	pcomp	of,Because
R1461	T2658	T2659	amod	better,accessibility
R1462	T2659	T2655	pobj	accessibility,Because
R1463	T2660	T2659	cc	and,accessibility
R1464	T2661	T2662	amod	larger,amounts
R1465	T2662	T2659	conj	amounts,accessibility
R1466	T2663	T2662	amod	available,amounts
R1467	T2664	T2665	dep	that,led
R1468	T2665	T2659	relcl	led,accessibility
R1469	T2666	T2665	prep	to,led
R1470	T2667	T2668	amod	clear,results
R1471	T2668	T2666	pobj	results,to
R1472	T2669	T2656	punct	", ",included
R1473	T2670	T2656	nsubj	we,included
R1474	T2671	T2672	poss	our,data
R1475	T2672	T2656	dobj	data,included
R1476	T2673	T2672	acl	obtained,data
R1477	T2674	T2673	prep	with,obtained
R1478	T2675	T2676	amod	human,blood
R1479	T2676	T2674	pobj	blood,with
R1480	T2677	T2656	punct	.,included
R1481	T2679	T2680	advcl	Independent,released
R1482	T2681	T2679	prep	of,Independent
R1483	T2682	T2683	det	the,presence
R1484	T2683	T2681	pobj	presence,of
R1485	T2684	T2683	prep	of,presence
R1486	T2685	T2686	compound	annexin,A7
R1487	T2686	T2684	pobj	A7,of
R1488	T2687	T2688	det	both,types
R1489	T2688	T2680	nsubjpass	types,released
R1490	T2689	T2688	prep	of,types
R1491	T2690	T2689	pobj	exovesicles,of
R1492	T2691	T2688	punct	", ",types
R1493	T2692	T2693	nmod	micro,nanovesicles
R1494	T2693	T2688	appos	nanovesicles,types
R1495	T2694	T2693	punct	-,nanovesicles
R1496	T2695	T2693	cc	and,nanovesicles
R1497	T2696	T2680	punct	", ",released
R1498	T2697	T2680	auxpass	were,released
R1499	T2698	T2680	prep	after,released
R1500	T2699	T2700	compound	Ca2+,ionophore
R1501	T2700	T2702	compound	ionophore,treatment
R1502	T2701	T2700	punct	/,ionophore
R1503	T2702	T2698	pobj	treatment,after
R1504	T2703	T2704	mark	as,determined
R1505	T2704	T2680	advcl	determined,released
R1506	T2705	T2704	agent	by,determined
R1507	T2706	T2707	compound	acetylcholine,esterase
R1508	T2707	T2708	compound	esterase,activity
R1509	T2708	T2705	pobj	activity,by
R1510	T2709	T2708	cc	and,activity
R1511	T2710	T2711	amod	microscopic,examination
R1512	T2711	T2708	conj	examination,activity
R1513	T2712	T2680	punct	.,released
R1514	T2714	T2715	compound	Annexin,A7
R1515	T2715	T2716	nsubj	A7,is
R1516	T2717	T2716	acomp	present,is
R1517	T2718	T2716	prep	in,is
R1518	T2719	T2720	preconj	both,types
R1519	T2720	T2718	pobj	types,in
R1520	T2721	T2720	compound	vesicle,types
R1521	T2722	T2723	advmod	where,is
R1522	T2723	T2720	advcl	is,types
R1523	T2724	T2723	nsubj	it,is
R1524	T2725	T2726	advmod	more,enriched
R1525	T2726	T2723	acomp	enriched,is
R1526	T2727	T2723	prep	in,is
R1527	T2728	T2727	pobj	nanovesicles,in
R1528	T2729	T2730	punct	(,Fig.
R1529	T2730	T2716	parataxis	Fig.,is
R1530	T2731	T2730	nummod	2,Fig.
R1531	T2732	T2730	punct	),Fig.
R1532	T2733	T2716	punct	.,is
R1533	T2735	T2736	det	The,isoform
R1534	T2736	T2739	nsubj	isoform,is
R1535	T2737	T2738	nummod	51,kDa
R1536	T2738	T2736	compound	kDa,isoform
R1537	T2740	T2739	advmod	only,is
R1538	T2741	T2739	acomp	detectable,is
R1539	T2742	T2739	prep	in,is
R1540	T2743	T2742	pobj	nanovesicles,in
R1541	T2744	T2739	punct	.,is
R1542	T2746	T2747	det	The,quantity
R1543	T2747	T2748	nsubj	quantity,differ
R1544	T2749	T2747	prep	of,quantity
R1545	T2750	T2751	det	both,types
R1546	T2751	T2749	pobj	types,of
R1547	T2752	T2751	compound	vesicle,types
R1548	T2753	T2748	aux	did,differ
R1549	T2754	T2748	neg	not,differ
R1550	T2755	T2748	prep	between,differ
R1551	T2756	T2757	amod	wild,type
R1552	T2757	T2758	nmod	type,vesicles
R1553	T2758	T2755	pobj	vesicles,between
R1554	T2759	T2757	cc	and,type
R1555	T2760	T2761	compound	knock,out
R1556	T2761	T2757	conj	out,type
R1557	T2762	T2763	amod	red,cell
R1558	T2763	T2758	compound	cell,vesicles
R1559	T2764	T2763	compound	blood,cell
R1560	T2765	T2766	mark	as,determined
R1561	T2766	T2748	advcl	determined,differ
R1562	T2767	T2766	agent	by,determined
R1563	T2768	T2769	det	the,values
R1564	T2769	T2767	pobj	values,by
R1565	T2770	T2769	compound	AChE,values
R1566	T2771	T2769	punct	-,values
R1567	T2772	T2773	punct	(,both
R1568	T2773	T2769	parataxis	both,values
R1569	T2774	T2775	compound	A405,nanovesicles
R1570	T2775	T2776	dep	nanovesicles,0.18
R1571	T2776	T2773	dep	0.18,both
R1572	T2777	T2776	punct	: ,0.18
R1573	T2778	T2776	punct	~,0.18
R1574	T2779	T2773	punct	;,both
R1575	T2780	T2781	compound	A405,microvesicles
R1576	T2781	T2782	dep	microvesicles,0.9
R1577	T2782	T2773	dep	0.9,both
R1578	T2783	T2782	punct	: ,0.9
R1579	T2784	T2782	punct	~,0.9
R1580	T2785	T2773	punct	;,both
R1581	T2786	T2773	punct	", ",both
R1596	T2803	T2802	nsubjpass	it,described
R1597	T2804	T2802	aux	has,described
R1598	T2805	T2802	auxpass	been,described
R1599	T2806	T2807	aux	to,fuse
R1600	T2807	T2802	xcomp	fuse,described
R1601	T2808	T2807	dobj	membranes,fuse
R1602	T2809	T2797	punct	", ",is
R1603	T2810	T2797	neg	not,is
R1604	T2811	T2812	det	a,component
R1605	T2812	T2797	attr	component,is
R1606	T2813	T2812	amod	key,component
R1607	T2814	T2812	prep	in,component
R1608	T2815	T2816	det	the,process
R1609	T2816	T2814	pobj	process,in
R1610	T2817	T2816	prep	of,process
R1611	T2818	T2819	det	the,formation
R1612	T2819	T2817	pobj	formation,of
R1613	T2820	T2819	prep	of,formation
R1614	T2821	T2822	amod	red,cell
R1615	T2822	T2824	compound	cell,exovesicles
R1616	T2823	T2822	compound	blood,cell
R1617	T2824	T2820	pobj	exovesicles,of
R1618	T2825	T2795	punct	.,appears
R1619	T2827	T2828	advmod	When,probed
R1620	T2828	T2830	advcl	probed,found
R1621	T2829	T2828	nsubj	we,probed
R1622	T2831	T2828	prep	for,probed
R1623	T2832	T2833	det	the,presence
R1624	T2833	T2831	pobj	presence,for
R1625	T2834	T2833	prep	of,presence
R1626	T2835	T2834	pobj	sorcin,of
R1627	T2836	T2828	prep	in,probed
R1628	T2837	T2838	amod	wild,type
R1629	T2838	T2839	nmod	type,vesicles
R1630	T2839	T2836	pobj	vesicles,in
R1631	T2840	T2838	cc	and,type
R1632	T2841	T2838	conj	mutant,type
R1633	T2842	T2830	nsubj	we,found
R1634	T2843	T2844	mark	that,reduced
R1635	T2844	T2830	ccomp	reduced,found
R1636	T2845	T2846	det	the,levels
R1637	T2846	T2844	nsubjpass	levels,reduced
R1638	T2847	T2846	compound	sorcin,levels
R1639	T2848	T2844	auxpass	were,reduced
R1640	T2849	T2844	prep	in,reduced
R1641	T2850	T2851	det	the,nanovesicles
R1642	T2851	T2849	pobj	nanovesicles,in
R1643	T2852	T2851	amod	mutant,nanovesicles
R1644	T2853	T2854	punct	(,Fig.
R1645	T2854	T2830	parataxis	Fig.,found
R1646	T2855	T2854	nummod	2,Fig.
R1647	T2856	T2854	punct	),Fig.
R1648	T2857	T2830	punct	.,found
R1664	T2875	T2874	compound	iodixanol,gradients
R1665	T2876	T2874	compound	density,gradients
R1666	T2877	T2861	punct	.,used
R1667	T2879	T2880	det	Both,isoforms
R1668	T2880	T2881	nsubj	isoforms,were
R1669	T2882	T2881	acomp	present,were
R1670	T2883	T2881	prep	in,were
R1671	T2884	T2885	det	the,fraction
R1672	T2885	T2883	pobj	fraction,in
R1673	T2886	T2885	amod	soluble,fraction
R1674	T2887	T2888	advmod	as,as
R1675	T2888	T2883	cc	as,in
R1676	T2889	T2888	advmod	well,as
R1677	T2890	T2883	conj	in,in
R1678	T2891	T2892	det	the,fractions
R1679	T2892	T2890	pobj	fractions,in
R1680	T2893	T2892	compound	gradient,fractions
R1681	T2894	T2895	advmod	where,assumed
R1682	T2895	T2892	relcl	assumed,fractions
R1683	T2896	T2895	nsubjpass	they,assumed
R1684	T2897	T2895	auxpass	are,assumed
R1685	T2898	T2899	aux	to,associated
R1686	T2899	T2895	xcomp	associated,assumed
R1687	T2900	T2899	auxpass	be,associated
R1688	T2901	T2899	prep	with,associated
R1689	T2902	T2901	pobj	membranes,with
R1690	T2903	T2881	punct	.,were
R1691	T2905	T2906	det	These,membranes
R1692	T2906	T2907	nsubj	membranes,are
R1693	T2908	T2907	advmod	exclusively,are
R1694	T2909	T2910	compound	plasma,membranes
R1695	T2910	T2907	attr	membranes,are
R1696	T2911	T2912	mark	as,are
R1697	T2912	T2907	advcl	are,are
R1698	T2913	T2914	amod	red,cells
R1699	T2914	T2912	nsubj	cells,are
R1700	T2915	T2914	compound	blood,cells
R1701	T2916	T2912	acomp	free,are
R1702	T2917	T2916	prep	of,free
R1703	T2918	T2919	det	any,organelles
R1704	T2919	T2917	pobj	organelles,of
R1705	T2920	T2907	punct	.,are
R1706	T2922	T2923	det	The,distribution
R1707	T2923	T2924	nsubj	distribution,was
R1708	T2925	T2924	advmod	however,was
R1709	T2926	T2924	neg	not,was
R1710	T2927	T2924	acomp	homogeneous,was
R1711	T2928	T2924	prep	throughout,was
R1712	T2929	T2930	det	the,gradient
R1713	T2930	T2928	pobj	gradient,throughout
R1714	T2931	T2924	punct	.,was
R1715	T2933	T2934	nsubj	This,reflect
R1716	T2935	T2934	aux	could,reflect
R1717	T2936	T2937	det	the,binding
R1718	T2937	T2934	dobj	binding,reflect
R1719	T2938	T2937	prep	of,binding
R1720	T2939	T2940	compound	annexin,A7
R1721	T2940	T2938	pobj	A7,of
R1722	T2941	T2937	prep	to,binding
R1723	T2942	T2943	compound	membrane,subdomains
R1724	T2943	T2941	pobj	subdomains,to
R1725	T2944	T2945	dep	that,have
R1726	T2945	T2943	relcl	have,subdomains
R1727	T2946	T2947	amod	different,composition
R1728	T2947	T2945	dobj	composition,have
R1729	T2948	T2947	nmod	lipid,composition
R1730	T2949	T2948	cc	or,lipid
R1731	T2950	T2951	compound	lipid,protein
R1732	T2951	T2948	conj	protein,lipid
R1733	T2952	T2951	punct	/,protein
R1734	T2953	T2954	mark	as,discussed
R1735	T2954	T2934	advcl	discussed,reflect
R1736	T2955	T2954	agent	by,discussed
R1737	T2956	T2955	pobj	Salzer,by
R1738	T2957	T2958	advmod	et,al.
R1739	T2958	T2956	advmod	al.,Salzer
R1740	T2959	T2960	punct	[,7
R1741	T2960	T2934	parataxis	7,reflect
R1742	T2961	T2960	punct	],7
R1743	T2962	T2934	punct	.,reflect
R1744	T2964	T2965	advmod	Likewise,exhibit
R1745	T2966	T2965	punct	", ",exhibit
R1746	T2967	T2965	nsubj	sorcin,exhibit
R1747	T2968	T2965	aux	does,exhibit
R1748	T2969	T2965	neg	not,exhibit
R1749	T2970	T2971	det	a,distribution
R1750	T2971	T2965	dobj	distribution,exhibit
R1751	T2972	T2971	amod	homogeneous,distribution
R1752	T2973	T2965	prep	in,exhibit
R1753	T2974	T2975	det	the,gradient
R1754	T2975	T2973	pobj	gradient,in
R1755	T2976	T2965	punct	.,exhibit
R1756	T2978	T2979	advmod	Moreover,segregates
R1757	T2980	T2979	punct	", ",segregates
R1758	T2981	T2979	nsubj	it,segregates
R1759	T2982	T2979	prep	into,segregates
R1760	T2983	T2982	pobj	vesicles,into
R1761	T2984	T2985	dep	which,associated
R1762	T2985	T2983	relcl	associated,vesicles
R1763	T2986	T2985	auxpass	are,associated
R1764	T2987	T2985	neg	not,associated
R1765	T2988	T2985	prep	with,associated
R1766	T2989	T2990	compound	annexin,A7
R1767	T2990	T2988	pobj	A7,with
R1768	T2991	T2992	punct	(,Fig.
R1769	T2992	T2979	parataxis	Fig.,segregates
R1770	T2993	T2992	nummod	3,Fig.
R1771	T2994	T2992	punct	),Fig.
R1772	T2995	T2979	punct	.,segregates
R1773	T2997	T2998	nsubj	We,tested
R1774	T2999	T2998	advmod	also,tested
R1775	T3000	T2998	dobj	platelets,tested
R1776	T3001	T2998	prep	for,tested
R1777	T3002	T3003	compound	annexin,A7
R1778	T3003	T3004	compound	A7,expression
R1779	T3004	T3001	pobj	expression,for
R1780	T3005	T2998	cc	and,tested
R1781	T3006	T2998	conj	detected,tested
R1782	T3007	T3008	det	the,isoform
R1783	T3008	T3006	dobj	isoform,detected
R1784	T3009	T3010	nummod	47,kDa
R1785	T3010	T3008	compound	kDa,isoform
R1786	T3011	T3012	punct	(,Fig.
R1787	T3012	T3006	parataxis	Fig.,detected
R1788	T3013	T3012	nummod	1,Fig.
R1789	T3014	T3012	punct	),Fig.
R1790	T3015	T2998	punct	.,tested
R1795	T3280	T3281	det	The,lack
R1796	T3281	T3282	nsubj	lack,changes
R1797	T3283	T3281	prep	of,lack
R1798	T3284	T3285	compound	annexin,A7
R1799	T3285	T3283	pobj	A7,of
R1800	T3286	T3287	amod	red,cell
R1801	T3287	T3282	dobj	cell,changes
R1802	T3288	T3287	compound	blood,cell
R1803	T3289	T3287	appos	morphology,cell
R1804	T3290	T3289	cc	and,morphology
R1805	T3291	T3292	amod	osmotic,resistance
R1806	T3292	T3289	conj	resistance,morphology
R1807	T3294	T3295	mark	As,is
R1808	T3295	T3298	advcl	is,studied
R1809	T3296	T3297	compound	annexin,A7
R1810	T3297	T3295	nsubj	A7,is
R1811	T3299	T3300	det	a,component
R1812	T3300	T3295	attr	component,is
R1813	T3301	T3300	prep	of,component
R1814	T3302	T3303	amod	red,cell
R1815	T3303	T3305	compound	cell,vesicles
R1816	T3304	T3303	compound	blood,cell
R1817	T3305	T3301	pobj	vesicles,of
R1818	T3306	T3298	nsubj	we,studied
R1819	T3307	T3308	det	the,consequences
R1820	T3308	T3298	dobj	consequences,studied
R1821	T3309	T3308	prep	of,consequences
R1822	T3310	T3311	det	the,loss
R1823	T3311	T3309	pobj	loss,of
R1824	T3312	T3311	prep	of,loss
R1825	T3313	T3314	det	the,protein
R1826	T3314	T3312	pobj	protein,of
R1827	T3315	T3298	prep	in,studied
R1828	T3316	T3317	det	the,mouse
R1829	T3317	T3315	pobj	mouse,in
R1830	T3318	T3317	nmod	anxA7,mouse
R1831	T3319	T3318	punct	-,anxA7
R1832	T3320	T3318	punct	/,anxA7
R1833	T3321	T3318	punct	-,anxA7
R1834	T3322	T3298	prep	for,studied
R1835	T3323	T3324	amod	red,cell
R1836	T3324	T3322	pobj	cell,for
R1837	T3325	T3324	compound	blood,cell
R1838	T3326	T3324	appos	morphology,cell
R1839	T3327	T3326	cc	and,morphology
R1840	T3328	T3329	amod	osmotic,resistance
R1841	T3329	T3326	conj	resistance,morphology
R1842	T3330	T3298	punct	.,studied
R1843	T3332	T3333	prep	In,revealed
R1844	T3334	T3335	det	a,smear
R1845	T3335	T3332	pobj	smear,In
R1846	T3336	T3335	amod	standard,smear
R1847	T3337	T3335	punct	',smear
R1848	T3338	T3335	compound	blood,smear
R1849	T3339	T3333	punct	',revealed
R1850	T3340	T3341	nsubj	we,note
R1851	T3341	T3333	ccomp	note,revealed
R1852	T3342	T3341	aux	did,note
R1853	T3343	T3341	neg	not,note
R1854	T3344	T3345	det	a,deformation
R1855	T3345	T3341	dobj	deformation,note
R1856	T3346	T3345	prep	of,deformation
R1857	T3347	T3348	det	the,cells
R1858	T3348	T3346	pobj	cells,of
R1859	T3349	T3333	punct	", ",revealed
R1860	T3350	T3333	advmod	however,revealed
R1861	T3351	T3352	amod	dark,field
R1862	T3352	T3353	compound	field,microscopy
R1863	T3353	T3333	nsubj	microscopy,revealed
R1864	T3354	T3333	dobj	changes,revealed
R1865	T3355	T3354	prep	in,changes
R1866	T3356	T3355	pobj	shape,in
R1867	T3357	T3356	cc	and,shape
R1868	T3358	T3356	conj	diameter,shape
R1869	T3359	T3356	prep	of,shape
R1870	T3360	T3361	det	the,cells
R1871	T3361	T3359	pobj	cells,of
R1872	T3362	T3361	nmod	anxA7,cells
R1873	T3363	T3362	punct	-,anxA7
R1874	T3364	T3362	punct	/,anxA7
R1875	T3365	T3362	punct	-,anxA7
R1876	T3366	T3361	amod	red,cells
R1877	T3367	T3361	compound	blood,cells
R1878	T3368	T3333	punct	.,revealed
R1879	T3370	T3371	nsubj	They,had
R1880	T3372	T3373	det	a,diameter
R1902	T3394	T3389	nsubj	n,40
R1903	T3395	T3389	punct	=,40
R1904	T3396	T3389	punct	),40
R1905	T3397	T3373	punct	", ",diameter
R1906	T3398	T3399	det	a,impression
R1907	T3399	T3373	conj	impression,diameter
R1908	T3400	T3401	advmod	remarkably,lower
R1909	T3401	T3399	amod	lower,impression
R1910	T3402	T3399	amod	emphasized,impression
R1911	T3403	T3399	amod	central,impression
R1912	T3404	T3399	cc	and,impression
R1913	T3405	T3406	det	a,shape
R1914	T3406	T3399	conj	shape,impression
R1915	T3407	T3408	advmod	more,flat
R1916	T3408	T3406	amod	flat,shape
R1917	T3409	T3410	punct	(,Fig.
R1918	T3410	T3406	parataxis	Fig.,shape
R1919	T3411	T3410	nummod	4,Fig.
R1920	T3412	T3410	punct	),Fig.
R1921	T3413	T3371	punct	.,had
R1922	T3415	T3416	det	No,change
R1923	T3416	T3418	nsubjpass	change,measured
R1924	T3417	T3416	amod	significant,change
R1925	T3419	T3416	prep	in,change
R1926	T3420	T3421	det	the,volume
R1927	T3421	T3419	pobj	volume,in
R1928	T3422	T3421	amod	mean,volume
R1929	T3423	T3421	amod	corpuscular,volume
R1930	T3424	T3421	punct	(,volume
R1931	T3425	T3421	appos	MCV,volume
R1932	T3426	T3418	punct	),measured
R1933	T3427	T3418	auxpass	was,measured
R1934	T3428	T3418	prep	with,measured
R1935	T3429	T3430	det	the,counter
R1936	T3430	T3428	pobj	counter,with
R1937	T3431	T3430	nmod	ADVIA,counter
R1938	T3432	T3431	nummod	120,ADVIA
R1939	T3433	T3430	compound	cell,counter
R1940	T3434	T3418	punct	.,measured
R1975	T3474	T3475	advmod	where,play
R1976	T3475	T3469	relcl	play,cytoskeleton
R1977	T3476	T3477	compound	annexin,A7
R1978	T3477	T3475	nsubj	A7,play
R1979	T3478	T3475	aux	might,play
R1980	T3479	T3480	det	a,role
R1981	T3480	T3475	dobj	role,play
R1982	T3481	T3458	punct	.,depends
R1983	T3483	T3484	det	The,resistance
R1984	T3484	T3486	nsubj	resistance,is
R1985	T3485	T3484	amod	osmotic,resistance
R1986	T3487	T3484	punct	", ",resistance
R1987	T3488	T3489	dep	which,is
R1988	T3489	T3484	relcl	is,resistance
R1989	T3490	T3491	det	the,resistance
R1990	T3491	T3489	attr	resistance,is
R1991	T3492	T3491	prep	towards,resistance
R1992	T3493	T3492	pobj	changes,towards
R1993	T3494	T3489	prep	in,is
R1994	T3495	T3496	det	the,strength
R1995	T3496	T3494	pobj	strength,in
R1996	T3497	T3496	amod	extracellular,strength
R1997	T3498	T3496	amod	ionic,strength
R1998	T3499	T3486	punct	", ",is
R1999	T3500	T3501	det	a,assay
R2000	T3501	T3486	attr	assay,is
R2001	T3502	T3501	amod	convenient,assay
R2002	T3503	T3501	prep	for,assay
R2003	T3504	T3503	pobj	analysis,for
R2004	T3505	T3504	prep	of,analysis
R2005	T3506	T3507	det	the,integrity
R2006	T3507	T3505	pobj	integrity,of
R2007	T3508	T3509	amod	red,cell
R2008	T3509	T3507	compound	cell,integrity
R2009	T3510	T3509	compound	blood,cell
R2010	T3511	T3486	punct	.,is
R2011	T3513	T3514	nsubjpass	It,measured
R2012	T3515	T3514	auxpass	is,measured
R2013	T3516	T3514	prep	as,measured
R2014	T3517	T3518	det	the,concentration
R2015	T3518	T3516	pobj	concentration,as
R2016	T3519	T3520	compound	sodium,chloride
R2017	T3520	T3518	compound	chloride,concentration
R2018	T3521	T3522	prep	at,starts
R2019	T3522	T3518	relcl	starts,concentration
R2020	T3523	T3521	pobj	which,at
R2021	T3524	T3525	amod	cellular,lysis
R2022	T3525	T3522	nsubj	lysis,starts
R2023	T3526	T3518	punct	(,concentration
R2024	T3527	T3528	amod	minimal,resistance
R2025	T3528	T3518	appos	resistance,concentration
R2026	T3529	T3518	punct	),concentration
R2027	T3530	T3518	prep	up,concentration
R2028	T3531	T3530	prep	to,up
R2029	T3532	T3533	det	a,lysis
R2030	T3533	T3531	pobj	lysis,to
R2031	T3534	T3533	amod	complete,lysis
R2032	T3535	T3533	punct	(,lysis
R2033	T3536	T3537	amod	maximal,resistance
R2034	T3537	T3533	appos	resistance,lysis
R2035	T3538	T3533	punct	),lysis
R2036	T3539	T3533	prep	of,lysis
R2037	T3540	T3541	det	the,cells
R2038	T3541	T3539	pobj	cells,of
R2039	T3542	T3543	punct	[,33
R2040	T3543	T3514	parataxis	33,measured
R2041	T3544	T3543	punct	],33
R2042	T3545	T3514	punct	.,measured
R2043	T3547	T3548	amod	Osmotic,resistance
R2044	T3548	T3549	nsubj	resistance,increases
R2045	T3550	T3549	prep	with,increases
R2046	T3551	T3552	amod	higher,MCV
R2047	T3552	T3550	pobj	MCV,with
R2048	T3553	T3552	punct	", ",MCV
R2049	T3554	T3555	amod	larger,area
R2050	T3555	T3552	conj	area,MCV
R2051	T3556	T3555	compound	surface,area
R2052	T3557	T3555	cc	and,area
R2053	T3558	T3559	det	a,degree
R2054	T3559	T3555	conj	degree,area
R2055	T3560	T3559	amod	higher,degree
R2056	T3561	T3559	prep	of,degree
R2057	T3562	T3563	amod	cellular,metabolism
R2058	T3563	T3561	pobj	metabolism,of
R2059	T3564	T3552	acl	stabilizing,MCV
R2060	T3565	T3566	det	the,levels
R2061	T3566	T3564	dobj	levels,stabilizing
R2062	T3567	T3566	amod	intracellular,levels
R2063	T3568	T3566	compound	ion,levels
R2064	T3569	T3549	punct	.,increases
R2065	T3571	T3572	amod	Aged,cells
R2066	T3572	T3575	nsubj	cells,show
R2067	T3573	T3572	amod	red,cells
R2068	T3574	T3572	compound	blood,cells
R2069	T3576	T3577	det	a,MCV
R2070	T3577	T3575	dobj	MCV,show
R2071	T3578	T3577	amod	lowered,MCV
R2072	T3579	T3577	cc	and,MCV
R2073	T3580	T3581	amod	lower,resistance
R2074	T3581	T3577	conj	resistance,MCV
R2075	T3582	T3581	amod	osmotic,resistance
R2076	T3583	T3584	punct	[,33
R2077	T3584	T3575	parataxis	33,show
R2078	T3585	T3584	punct	],33
R2079	T3586	T3575	punct	.,show
R2080	T3588	T3589	amod	Similar,properties
R2081	T3589	T3590	nsubjpass	properties,observed
R2082	T3591	T3590	aux	can,observed
R2083	T3592	T3590	auxpass	be,observed
R2084	T3593	T3590	prep	in,observed
R2085	T3594	T3595	amod	red,cells
R2086	T3595	T3593	pobj	cells,in
R2087	T3596	T3595	compound	blood,cells
R2088	T3597	T3595	prep	with,cells
R2089	T3598	T3599	amod	lowered,permeability
R2090	T3599	T3597	pobj	permeability,with
R2091	T3600	T3599	compound	membrane,permeability
R2092	T3601	T3590	punct	.,observed
R2093	T3603	T3604	det	The,resistance
R2094	T3604	T3606	nsubj	resistance,is
R2095	T3605	T3604	amod	osmotic,resistance
R2096	T3607	T3604	prep	of,resistance
R2097	T3608	T3609	compound	annexin,A7
R2098	T3609	T3610	npadvmod	A7,deficient
R2099	T3610	T3611	amod	deficient,cells
R2100	T3611	T3607	pobj	cells,of
R2101	T3612	T3611	amod	red,cells
R2102	T3613	T3611	compound	blood,cells
R2103	T3614	T3615	advmod	significantly,increased
R2104	T3615	T3606	acomp	increased,is
R2105	T3616	T3606	prep	compared,is
R2106	T3617	T3616	prep	to,compared
R2107	T3618	T3619	amod	wild,type
R2108	T3619	T3620	compound	type,cells
R2109	T3620	T3617	pobj	cells,to
R2110	T3621	T3606	punct	.,is
R2111	T3623	T3624	det	The,value
R2112	T3624	T3627	nsubjpass	value,observed
R2113	T3625	T3626	amod	minimal,resistance
R2114	T3626	T3624	compound	resistance,value
R2115	T3628	T3624	prep	of,value
R2116	T3629	T3630	compound	knock,out
R2117	T3630	T3631	compound	out,cells
R2118	T3631	T3628	pobj	cells,of
R2119	T3632	T3627	auxpass	is,observed
R2120	T3633	T3627	prep	in,observed
R2121	T3634	T3635	det	a,solution
R2122	T3635	T3633	pobj	solution,in
R2123	T3636	T3637	nummod	0.60,%
R2124	T3637	T3635	compound	%,solution
R2125	T3638	T3635	compound	NaCl,solution
R2126	T3639	T3635	cc	versus,solution
R2127	T3640	T3641	nummod	0.65,%
R2128	T3641	T3635	conj	%,solution
R2129	T3642	T3641	prep	for,%
R2130	T3643	T3644	amod	wild,type
R2131	T3644	T3645	compound	type,cells
R2132	T3645	T3642	pobj	cells,for
R2133	T3646	T3627	punct	.,observed
R2134	T3648	T3649	nummod	50,%
R2135	T3649	T3650	compound	%,haemolysis
R2136	T3650	T3651	nsubjpass	haemolysis,achieved
R2137	T3652	T3651	auxpass	is,achieved
R2138	T3653	T3651	prep	at,achieved
R2139	T3654	T3655	nummod	0.516,%
R2140	T3655	T3656	compound	%,solution
R2141	T3656	T3653	pobj	solution,at
R2142	T3657	T3656	compound	NaCl,solution
R2143	T3658	T3656	prep	for,solution
R2144	T3659	T3660	compound	knock,out
R2145	T3660	T3658	pobj	out,for
R2146	T3661	T3656	cc	versus,solution
R2147	T3662	T3663	nummod	0.564,%
R2148	T3663	T3664	compound	%,NaCl
R2149	T3664	T3656	conj	NaCl,solution
R2150	T3665	T3664	prep	for,NaCl
R2151	T3666	T3667	amod	wild,type
R2152	T3667	T3668	compound	type,cells
R2153	T3668	T3665	pobj	cells,for
R2154	T3669	T3670	punct	(,Fig.
R2155	T3670	T3651	parataxis	Fig.,achieved
R2156	T3671	T3672	compound	mean,values
R2157	T3672	T3670	dep	values,Fig.
R2158	T3673	T3670	punct	", ",Fig.
R2159	T3674	T3675	nsubj	p,0.00066
R2160	T3675	T3670	ccomp	0.00066,Fig.
R2161	T3676	T3675	punct	=,0.00066
R2162	T3677	T3670	punct	", ",Fig.
R2163	T3678	T3679	nsubj	n,8
R2164	T3679	T3670	ccomp	8,Fig.
R2165	T3680	T3679	punct	=,8
R2166	T3681	T3670	punct	;,Fig.
R2167	T3682	T3670	nummod	5,Fig.
R2168	T3683	T3670	punct	),Fig.
R2169	T3684	T3651	punct	.,achieved
R2170	T3686	T3687	det	The,width
R2171	T3687	T3689	nsubj	width,is
R2172	T3688	T3687	compound	resistance,width
R2173	T3690	T3687	prep	of,width
R2174	T3691	T3692	det	the,cells
R2175	T3692	T3690	pobj	cells,of
R2176	T3693	T3694	compound	knock,out
R2177	T3694	T3692	compound	out,cells
R2178	T3695	T3696	advmod	slightly,lower
R2179	T3696	T3689	acomp	lower,is
R2180	T3697	T3698	punct	(,solution
R2181	T3698	T3696	parataxis	solution,lower
R2182	T3699	T3700	nummod	0.20,%
R2183	T3700	T3701	nmod	%,NaCl
R2184	T3701	T3698	compound	NaCl,solution
R2185	T3702	T3703	advmod	instead,of
R2186	T3703	T3700	cc	of,%
R2187	T3704	T3705	nummod	0.25,%
R2188	T3705	T3700	conj	%,%
R2189	T3706	T3698	punct	),solution
R2190	T3707	T3689	punct	.,is
R2191	T3709	T3710	nsubj	We,performed
R2192	T3711	T3710	advmod	also,performed
R2193	T3712	T3713	amod	direct,measurements
R2194	T3713	T3710	dobj	measurements,performed
R2195	T3714	T3713	prep	of,measurements
R2196	T3715	T3716	det	the,deformability
R2197	T3716	T3714	pobj	deformability,of
R2198	T3717	T3718	amod	red,cell
R2199	T3718	T3716	compound	cell,deformability
R2200	T3719	T3718	compound	blood,cell
R2201	T3720	T3716	compound	membrane,deformability
R2202	T3721	T3710	punct	", ",performed
R2203	T3722	T3723	aux	to,characterize
R2204	T3723	T3710	advcl	characterize,performed
R2205	T3724	T3723	advmod	further,characterize
R2206	T3725	T3726	det	a,role
R2207	T3726	T3723	dobj	role,characterize
R2208	T3727	T3726	amod	possible,role
R2209	T3728	T3726	prep	of,role
R2210	T3729	T3730	compound	annexin,A7
R2211	T3730	T3728	pobj	A7,of
R2212	T3731	T3726	prep	on,role
R2213	T3732	T3733	det	the,stability
R2214	T3733	T3731	pobj	stability,on
R2215	T3734	T3733	compound	membrane,stability
R2216	T3735	T3710	punct	.,performed
R2217	T3737	T3738	prep	With,tried
R2218	T3739	T3740	compound	micropipette,experiments
R2219	T3740	T3737	pobj	experiments,With
R2220	T3741	T3738	nsubj	we,tried
R2221	T3742	T3743	aux	to,correlate
R2222	T3743	T3738	xcomp	correlate,tried
R2223	T3744	T3745	amod	mechanical,characteristics
R2224	T3745	T3743	dobj	characteristics,correlate
R2225	T3746	T3745	prep	of,characteristics
R2226	T3747	T3748	det	the,cells
R2227	T3748	T3746	pobj	cells,of
R2228	T3749	T3748	amod	red,cells
R2229	T3750	T3748	compound	blood,cells
R2230	T3751	T3743	prep	with,correlate
R2250	T3773	T3774	det	these,experiments
R2251	T3774	T3772	pobj	experiments,in
R2252	T3775	T3776	punct	(,M.
R2253	T3776	T3757	meta	M.,observe
R2254	T3777	T3776	nmod	Heil,M.
R2255	T3778	T3776	punct	", ",M.
R2256	T3779	T3776	conj	B.,M.
R2257	T3780	T3779	nmod	Hoffmann,B.
R2258	T3781	T3779	cc	and,B.
R2259	T3782	T3779	conj	R.,B.
R2260	T3783	T3782	nmod	Merkel,R.
R2261	T3784	T3782	punct	", ",R.
R2262	T3785	T3786	amod	unpublished,results
R2263	T3786	T3782	conj	results,R.
R2264	T3787	T3786	punct	),results
R2265	T3788	T3757	punct	.,observe
R2266	T3790	T3791	advmod	However,was
R2267	T3792	T3791	punct	", ",was
R2268	T3793	T3794	det	the,distinction
R2269	T3794	T3791	nsubj	distinction,was
R2270	T3795	T3794	acl	observed,distinction
R2271	T3796	T3795	prep	in,observed
R2272	T3797	T3798	det	the,experiments
R2273	T3798	T3796	pobj	experiments,in
R2274	T3799	T3800	amod	osmotic,resistance
R2275	T3800	T3798	compound	resistance,experiments
R2276	T3801	T3802	advmod	highly,significant
R2277	T3802	T3791	acomp	significant,was
R2278	T3803	T3791	cc	and,was
R2279	T3804	T3791	conj	reflects,was
R2280	T3805	T3806	det	a,value
R2281	T3806	T3804	dobj	value,reflects
R2282	T3807	T3806	amod	mean,value
R2283	T3808	T3806	prep	over,value
R2284	T3809	T3810	det	a,number
R2285	T3810	T3808	pobj	number,over
R2286	T3811	T3810	amod	high,number
R2287	T3812	T3810	prep	of,number
R2288	T3813	T3814	amod	different,cells
R2289	T3814	T3812	pobj	cells,of
R2290	T3815	T3814	amod	red,cells
R2291	T3816	T3814	compound	blood,cells
R2292	T3817	T3791	punct	.,was
R2293	T3819	T3820	det	These,data
R2294	T3820	T3821	nsubj	data,suggest
R2295	T3822	T3823	mark	that,contributes
R2296	T3823	T3821	ccomp	contributes,suggest
R2297	T3824	T3825	compound	annexin,A7
R2298	T3825	T3823	nsubj	A7,contributes
R2299	T3826	T3823	prep	to,contributes
R2300	T3827	T3828	det	the,shape
R2301	T3828	T3826	pobj	shape,to
R2302	T3829	T3828	prep	of,shape
R2303	T3830	T3831	amod	red,cells
R2304	T3831	T3829	pobj	cells,of
R2305	T3832	T3831	compound	blood,cells
R2306	T3833	T3828	cc	and,shape
R2307	T3834	T3835	det	the,resistance
R2308	T3835	T3828	conj	resistance,shape
R2309	T3836	T3835	amod	osmotic,resistance
R2310	T3837	T3821	punct	.,suggest
R2311	T3839	T3840	mark	As,observed
R2312	T3840	T3844	advcl	observed,do
R2313	T3841	T3840	nsubj	we,observed
R2314	T3842	T3840	aux	have,observed
R2315	T3843	T3840	neg	not,observed
R2316	T3845	T3846	det	a,binding
R2317	T3846	T3840	dobj	binding,observed
R2318	T3847	T3846	prep	of,binding
R2319	T3848	T3849	compound	annexin,A7
R2320	T3849	T3847	pobj	A7,of
R2321	T3850	T3846	prep	to,binding
R2322	T3851	T3852	compound	F,actin
R2323	T3852	T3850	pobj	actin,to
R2324	T3853	T3852	punct	-,actin
R2325	T3854	T3855	punct	(,shown
R2326	T3855	T3840	parataxis	shown,observed
R2327	T3856	T3855	nsubj	data,shown
R2328	T3857	T3855	neg	not,shown
R2329	T3858	T3855	punct	),shown
R2330	T3859	T3844	nsubj	it,do
R2331	T3860	T3844	aux	could,do
R2332	T3861	T3844	advmod	so,do
R2333	T3862	T3863	preconj	either,by
R2334	T3863	T3844	prep	by,do
R2335	T3864	T3863	pobj	alteration,by
R2336	T3865	T3864	prep	of,alteration
R2337	T3866	T3867	det	the,rigidity
R2338	T3867	T3865	pobj	rigidity,of
R2339	T3868	T3867	compound	membrane,rigidity
R2340	T3869	T3863	cc	and,by
R2341	T3870	T3869	punct	/,and
R2342	T3871	T3869	cc	or,and
R2343	T3872	T3863	conj	by,by
R2344	T3873	T3872	pcomp	affecting,by
R2345	T3874	T3875	det	the,homeostasis
R2346	T3875	T3873	dobj	homeostasis,affecting
R2347	T3876	T3875	compound	ion,homeostasis
R2348	T3877	T3844	punct	.,do
R2349	T4078	T4079	det	The,lack
R2350	T4079	T4080	nsubj	lack,affects
R2351	T4081	T4079	prep	of,lack
R2352	T4082	T4083	compound	annexin,A7
R2353	T4083	T4081	pobj	A7,of
R2354	T4084	T4085	amod	primary,haemostasis
R2355	T4085	T4080	dobj	haemostasis,affects
R2356	T4086	T4087	advmod	ex,vivo
R2357	T4087	T4080	advmod	vivo,affects
R2358	T4089	T4090	det	The,use
R2359	T4090	T4091	nsubj	use,allowed
R2360	T4092	T4090	prep	of,use
R2361	T4093	T4094	det	an,counter
R2362	T4094	T4092	pobj	counter,of
R2363	T4095	T4094	amod	advanced,counter
R2364	T4096	T4094	amod	electronic,counter
R2365	T4097	T4094	compound	cell,counter
R2366	T4098	T4094	punct	/,counter
R2367	T4099	T4100	compound	flow,cytometer
R2368	T4100	T4094	appos	cytometer,counter
R2369	T4101	T4094	punct	(,counter
R2370	T4102	T4094	appos	ADVIA,counter
R2371	T4103	T4102	nummod	120,ADVIA
R2372	T4104	T4091	punct	),allowed
R2373	T4105	T4106	nsubj	us,screen
R2374	T4106	T4091	ccomp	screen,allowed
R2375	T4107	T4106	aux	to,screen
R2376	T4108	T4109	amod	other,parameters
R2377	T4109	T4106	dobj	parameters,screen
R2378	T4110	T4111	advmod	as,well
R2379	T4111	T4106	advmod	well,screen
R2380	T4112	T4106	prep	despite,screen
R2381	T4113	T4112	pcomp	of,despite
R2382	T4114	T4115	det	the,volume
R2383	T4115	T4112	pobj	volume,despite
R2384	T4116	T4115	amod	limited,volume
R2385	T4117	T4115	amod	murine,volume
R2386	T4118	T4115	compound	blood,volume
R2387	T4119	T4091	punct	.,allowed
R2388	T4121	T4122	nsubj	We,analysed
R2389	T4123	T4122	dobj	leukocytes,analysed
R2390	T4124	T4123	punct	", ",leukocytes
R2391	T4125	T4126	amod	red,cells
R2392	T4126	T4123	conj	cells,leukocytes
R2393	T4127	T4126	compound	blood,cells
R2394	T4128	T4126	punct	", ",cells
R2395	T4129	T4130	compound	haemoglobin,content
R2396	T4130	T4126	conj	content,cells
R2397	T4131	T4130	punct	", ",content
R2398	T4132	T4130	conj	haematocrit,content
R2399	T4133	T4132	punct	", ",haematocrit
R2400	T4134	T4135	amod	mean,volume
R2401	T4135	T4132	conj	volume,haematocrit
R2402	T4136	T4135	amod	cellular,volume
R2403	T4137	T4135	punct	", ",volume
R2404	T4138	T4139	amod	mean,haemoglobin
R2405	T4139	T4135	conj	haemoglobin,volume
R2406	T4140	T4139	amod	cellular,haemoglobin
R2407	T4141	T4139	punct	", ",haemoglobin
R2408	T4142	T4143	amod	mean,haemoglobin
R2409	T4143	T4145	compound	haemoglobin,concentration
R2410	T4144	T4143	amod	cellular,haemoglobin
R2411	T4145	T4139	conj	concentration,haemoglobin
R2412	T4146	T4145	punct	", ",concentration
R2413	T4147	T4145	conj	platelets,concentration
R2414	T4148	T4147	punct	", ",platelets
R2415	T4149	T4147	conj	neutrophiles,platelets
R2416	T4150	T4149	punct	", ",neutrophiles
R2417	T4151	T4149	conj	lymphocytes,neutrophiles
R2418	T4152	T4151	punct	", ",lymphocytes
R2419	T4153	T4151	conj	monocytes,lymphocytes
R2420	T4154	T4153	punct	", ",monocytes
R2421	T4155	T4153	conj	eosinophiles,monocytes
R2422	T4156	T4155	cc	and,eosinophiles
R2423	T4157	T4155	conj	basophiles,eosinophiles
R2424	T4158	T4122	punct	.,analysed
R2425	T4160	T4161	prep	In,found
R2426	T4162	T4163	det	these,tests
R2427	T4163	T4160	pobj	tests,In
R2428	T4164	T4163	prep	of,tests
R2429	T4165	T4166	amod	whole,blood
R2430	T4166	T4164	pobj	blood,of
R2431	T4167	T4161	nsubj	we,found
R2432	T4168	T4161	advmod	only,found
R2433	T4169	T4170	det	a,change
R2434	T4170	T4161	dobj	change,found
R2435	T4171	T4170	prep	in,change
R2436	T4172	T4173	det	the,numbers
R2437	T4173	T4171	pobj	numbers,in
R2438	T4174	T4173	compound	platelet,numbers
R2439	T4175	T4161	punct	", ",found
R2440	T4176	T4177	mark	whereas,affected
R2441	T4177	T4161	advcl	affected,found
R2442	T4178	T4179	det	all,parameters
R2443	T4179	T4177	nsubjpass	parameters,affected
R2444	T4180	T4179	amod	other,parameters
R2445	T4181	T4179	amod	haematological,parameters
R2446	T4182	T4177	auxpass	were,affected
R2447	T4183	T4177	neg	not,affected
R2448	T4184	T4161	punct	.,found
R2449	T4186	T4187	det	The,counts
R2450	T4187	T4190	nsubjpass	counts,determined
R2451	T4188	T4187	amod	mean,counts
R2452	T4189	T4187	compound	platelet,counts
R2453	T4191	T4187	prep	from,counts
R2454	T4192	T4193	amod	wild,type
R2455	T4193	T4194	nmod	type,mice
R2456	T4194	T4191	pobj	mice,from
R2457	T4195	T4193	cc	and,type
R2458	T4196	T4193	conj	anxA7,type
R2459	T4197	T4196	punct	-,anxA7
R2460	T4198	T4196	punct	/,anxA7
R2461	T4199	T4196	punct	-,anxA7
R2462	T4200	T4194	amod	mutant,mice
R2463	T4201	T4190	auxpass	are,determined
R2464	T4202	T4190	prep	as,determined
R2465	T4203	T4204	quantmod	674,103
R2466	T4204	T4202	pobj	103,as
R2467	T4205	T4204	punct	×,103
R2468	T4206	T4207	punct	/,μl
R2469	T4207	T4204	prep	μl,103
R2470	T4208	T4204	cc	and,103
R2471	T4209	T4210	quantmod	774,103
R2472	T4210	T4204	conj	103,103
R2473	T4211	T4210	punct	×,103
R2474	T4212	T4213	punct	/,μl
R2475	T4213	T4210	prep	μl,103
R2476	T4214	T4190	punct	", ",determined
R2477	T4215	T4190	advmod	respectively,determined
R2478	T4216	T4190	punct	.,determined
R2479	T4218	T4219	det	The,counts
R2480	T4219	T4221	nsubj	counts,are
R2481	T4220	T4219	compound	platelet,counts
R2482	T4222	T4219	prep	in,counts
R2483	T4223	T4224	compound	knock,out
R2484	T4224	T4225	compound	out,mice
R2485	T4225	T4222	pobj	mice,in
R2486	T4226	T4227	advmod	significantly,higher
R2487	T4227	T4221	acomp	higher,are
R2488	T4228	T4229	punct	(,14
R2489	T4229	T4227	parataxis	14,higher
R2490	T4230	T4231	nsubj	p,0.0275
R2491	T4231	T4229	ccomp	0.0275,14
R2492	T4232	T4231	punct	=,0.0275
R2493	T4233	T4229	punct	;,14
R2494	T4234	T4235	compound	n,out
R2495	T4235	T4237	nsubj	out,11
R2496	T4236	T4235	compound	knock,out
R2497	T4237	T4229	ccomp	11,14
R2498	T4238	T4237	punct	=,11
R2499	T4239	T4229	punct	", ",14
R2500	T4240	T4241	nmod	n,type
R2501	T4241	T4229	nsubj	type,14
R2502	T4242	T4241	amod	wild,type
R2503	T4243	T4229	punct	=,14
R2504	T4244	T4229	punct	),14
R2505	T4245	T4221	punct	.,are
R2506	T4247	T4248	det	An,increase
R2507	T4248	T4249	nsubj	increase,is
R2508	T4250	T4248	prep	in,increase
R2509	T4251	T4252	compound	platelet,counts
R2510	T4252	T4250	pobj	counts,in
R2511	T4253	T4254	det	a,disorder
R2512	T4254	T4249	attr	disorder,is
R2513	T4255	T4256	advmod	rather,uncommon
R2514	T4256	T4254	amod	uncommon,disorder
R2515	T4257	T4249	punct	.,is
R2516	T4259	T4260	prep	In,increase
R2517	T4261	T4259	pobj	humans,In
R2518	T4262	T4260	punct	", ",increase
R2519	T4263	T4264	compound	platelet,counts
R2520	T4264	T4260	nsubj	counts,increase
R2521	T4265	T4260	advmod	normally,increase
R2522	T4266	T4267	advmod	only,transiently
R2523	T4267	T4260	advmod	transiently,increase
R2524	T4268	T4260	prep	as,increase
R2525	T4269	T4268	pobj	in,as
R2526	T4270	T4271	amod	reactive,thrombocytosis
R2527	T4271	T4269	pobj	thrombocytosis,in
R2528	T4272	T4269	cc	and,in
R2529	T4273	T4269	conj	under,in
R2530	T4274	T4275	amod	postoperative,conditions
R2531	T4275	T4273	pobj	conditions,under
R2532	T4276	T4260	cc	or,increase
R2533	T4277	T4278	auxpass	are,increased
R2534	T4278	T4260	conj	increased,increase
R2535	T4279	T4278	advmod	largely,increased
R2536	T4280	T4278	prep	in,increased
R2537	T4281	T4282	amod	neoplastic,diseases
R2538	T4282	T4280	pobj	diseases,in
R2539	T4283	T4260	punct	.,increase
R2540	T4285	T4286	prep	By,are
R2541	T4287	T4285	pobj	contrast,By
R2542	T4288	T4286	punct	", ",are
R2543	T4289	T4290	det	the,mice
R2544	T4290	T4286	nsubj	mice,are
R2545	T4291	T4290	nmod	anxA7,mice
R2546	T4292	T4291	punct	-,anxA7
R2547	T4293	T4291	punct	/,anxA7
R2548	T4294	T4291	punct	-,anxA7
R2549	T4295	T4286	acomp	healthy,are
R2550	T4296	T4295	cc	and,healthy
R2551	T4297	T4295	conj	viable,healthy
R2552	T4298	T4286	punct	.,are
R2553	T4300	T4301	advmod	Therefore,tested
R2554	T4302	T4301	nsubj	we,tested
R2555	T4303	T4304	det	the,function
R2556	T4304	T4301	dobj	function,tested
R2557	T4305	T4304	compound	platelet,function
R2558	T4306	T4301	cc	and,tested
R2559	T4307	T4301	conj	performed,tested
R2560	T4308	T4309	compound	aggregometry,measurements
R2561	T4309	T4307	dobj	measurements,performed
R2562	T4310	T4307	prep	with,performed
R2563	T4311	T4312	npadvmod	platelet,rich
R2564	T4312	T4313	amod	rich,plasma
R2565	T4313	T4310	pobj	plasma,with
R2566	T4314	T4301	punct	.,tested
R2567	T4316	T4317	compound	Platelet,activation
R2568	T4317	T4318	nsubjpass	activation,observed
R2569	T4319	T4318	auxpass	is,observed
R2570	T4320	T4318	prep	as,observed
R2571	T4321	T4322	det	a,change
R2572	T4322	T4320	pobj	change,as
R2573	T4323	T4322	amod	morphological,change
R2574	T4324	T4322	prep	from,change
R2575	T4325	T4326	det	the,state
R2576	T4326	T4324	pobj	state,from
R2577	T4327	T4326	amod	resting,state
R2578	T4328	T4326	amod	discoid,state
R2579	T4329	T4322	prep	to,change
R2580	T4330	T4331	amod	activated,cells
R2581	T4331	T4329	pobj	cells,to
R2582	T4332	T4331	amod	spherical,cells
R2583	T4333	T4331	prep	with,cells
R2584	T4334	T4333	pobj	pseudopods,with
R2585	T4335	T4318	punct	.,observed
R2586	T4337	T4338	det	The,changes
R2587	T4338	T4340	nsubj	changes,are
R2588	T4339	T4338	amod	morphological,changes
R2589	T4341	T4340	prep	due,are
R2590	T4342	T4341	pcomp	to,due
R2591	T4343	T4344	amod	cytoskeletal,rearrangements
R2592	T4344	T4341	pobj	rearrangements,due
R2593	T4345	T4340	punct	.,are
R2594	T4347	T4348	advmod	In,vitro
R2595	T4348	T4349	advmod	vitro,form
R2596	T4350	T4351	det	the,cells
R2597	T4351	T4349	nsubj	cells,form
R2598	T4352	T4351	amod	activated,cells
R2599	T4353	T4349	dobj	aggregates,form
R2600	T4354	T4349	advcl	recruiting,form
R2601	T4355	T4356	amod	additional,cells
R2602	T4356	T4354	dobj	cells,recruiting
R2603	T4357	T4354	prep	in,recruiting
R2604	T4358	T4359	det	the,solution
R2605	T4359	T4357	pobj	solution,in
R2606	T4360	T4361	advmod	thereby,reducing
R2607	T4361	T4354	dep	reducing,recruiting
R2608	T4362	T4363	poss	its,cloudiness
R2609	T4363	T4361	dobj	cloudiness,reducing
R2610	T4364	T4349	punct	.,form
R2611	T4366	T4367	nsubj	Analysis,showed
R2612	T4368	T4366	prep	of,Analysis
R2613	T4369	T4370	det	the,values
R2614	T4370	T4368	pobj	values,of
R2615	T4371	T4370	compound	transmission,values
R2616	T4372	T4370	prep	of,values
R2617	T4373	T4374	compound	aggregation,curves
R2618	T4374	T4372	pobj	curves,of
R2619	T4375	T4366	prep	after,Analysis
R2620	T4376	T4377	compound	platelet,activation
R2621	T4377	T4375	pobj	activation,after
R2622	T4378	T4377	prep	by,activation
R2623	T4379	T4380	compound	ristocetin,addition
R2624	T4380	T4378	pobj	addition,by
R2625	T4381	T4382	punct	(,cofactor
R2626	T4382	T4380	parataxis	cofactor,addition
R2627	T4383	T4384	compound	von,Willebrand
R2628	T4384	T4382	compound	Willebrand,cofactor
R2629	T4385	T4382	punct	),cofactor
R2630	T4386	T4387	mark	that,differed
R2631	T4387	T4367	ccomp	differed,showed
R2632	T4388	T4389	det	both,curves
R2633	T4389	T4387	nsubj	curves,differed
R2634	T4390	T4387	advmod	significantly,differed
R2635	T4391	T4387	prep	at,differed
R2636	T4392	T4393	det	the,point
R2637	T4393	T4391	pobj	point,at
R2638	T4394	T4393	compound	time,point
R2639	T4395	T4393	prep	of,point
R2640	T4396	T4397	nummod	seven,seconds
R2641	T4397	T4395	pobj	seconds,of
R2642	T4398	T4397	prep	after,seconds
R2643	T4399	T4400	compound	platelet,initiation
R2644	T4400	T4398	pobj	initiation,after
R2645	T4401	T4402	punct	(,Fig.
R2646	T4402	T4387	parataxis	Fig.,differed
R2647	T4403	T4404	nsubj	p,0.0287
R2648	T4404	T4402	ccomp	0.0287,Fig.
R2649	T4405	T4404	punct	=,0.0287
R2650	T4406	T4402	punct	", ",Fig.
R2651	T4407	T4408	compound	n,out
R2652	T4408	T4410	nsubj	out,16
R2653	T4409	T4408	compound	knock,out
R2654	T4410	T4402	ccomp	16,Fig.
R2655	T4411	T4410	punct	=,16
R2656	T4412	T4402	punct	", ",Fig.
R2657	T4413	T4414	nmod	n,type
R2658	T4414	T4416	nsubj	type,15
R2659	T4415	T4414	amod	wild,type
R2660	T4416	T4402	ccomp	15,Fig.
R2661	T4417	T4416	punct	=,15
R2662	T4418	T4402	punct	;,Fig.
R2663	T4419	T4402	nummod	6,Fig.
R2664	T4420	T4402	punct	),Fig.
R2665	T4421	T4367	punct	.,showed
R2666	T4423	T4424	compound	Annexin,A7
R2667	T4424	T4425	npadvmod	A7,deficient
R2668	T4425	T4426	amod	deficient,platelets
R2669	T4426	T4427	nsubj	platelets,showed
R2670	T4428	T4429	det	a,velocity
R2671	T4429	T4427	dobj	velocity,showed
R2672	T4430	T4431	advmod	slightly,lowered
R2673	T4431	T4429	amod	lowered,velocity
R2674	T4432	T4429	compound	aggregation,velocity
R2675	T4433	T4427	punct	.,showed
R2676	T4435	T4436	advmod	When,compared
R2677	T4436	T4438	advcl	compared,found
R2678	T4437	T4436	nsubj	we,compared
R2679	T4439	T4440	det	the,curves
R2680	T4440	T4436	dobj	curves,compared
R2681	T4441	T4440	compound	aggregation,curves
R2682	T4442	T4440	prep	of,curves
R2683	T4443	T4444	amod	human,platelets
R2684	T4444	T4442	pobj	platelets,of
R2685	T4445	T4444	prep	from,platelets
R2686	T4446	T4447	det	a,donor
R2687	T4447	T4445	pobj	donor,from
R2688	T4448	T4447	amod	healthy,donor
R2689	T4449	T4436	prep	with,compared
R2690	T4450	T4451	det	the,ones
R2691	T4451	T4449	pobj	ones,with
R2692	T4452	T4451	acl	obtained,ones
R2693	T4453	T4452	prep	from,obtained
R2694	T4454	T4455	det	an,individual
R2695	T4455	T4453	pobj	individual,from
R2696	T4456	T4455	prep	with,individual
R2697	T4457	T4458	det	a,defect
R2698	T4458	T4456	pobj	defect,with
R2699	T4459	T4460	nmod	von,Willebrand
R2700	T4460	T4461	nmod	Willebrand,factor
R2701	T4461	T4458	nmod	factor,defect
R2702	T4462	T4458	nmod	type,defect
R2703	T4463	T4462	nummod	1,type
R2704	T4464	T4438	punct	", ",found
R2705	T4465	T4438	nsubj	we,found
R2706	T4466	T4467	mark	that,was
R2707	T4467	T4438	ccomp	was,found
R2708	T4468	T4469	det	the,difference
R2709	T4469	T4467	nsubj	difference,was
R2710	T4470	T4469	prep	in,difference
R2711	T4471	T4472	det	the,curves
R2712	T4472	T4470	pobj	curves,in
R2713	T4473	T4474	advmod	much,more
R2714	T4474	T4475	advmod	more,pronounced
R2715	T4475	T4467	acomp	pronounced,was
R2716	T4476	T4477	mark	as,observed
R2717	T4477	T4467	advcl	observed,was
R2718	T4478	T4477	prep	in,observed
R2719	T4479	T4480	poss	our,studies
R2720	T4480	T4478	pobj	studies,in
R2721	T4481	T4480	prep	of,studies
R2722	T4482	T4483	amod	healthy,platelets
R2723	T4483	T4481	pobj	platelets,of
R2724	T4484	T4483	compound	mouse,platelets
R2725	T4485	T4483	cc	and,platelets
R2726	T4486	T4487	nmod	anxA7,platelets
R2727	T4487	T4483	conj	platelets,platelets
R2728	T4488	T4486	punct	-,anxA7
R2729	T4489	T4486	punct	/,anxA7
R2730	T4490	T4486	punct	-,anxA7
R2731	T4491	T4438	punct	.,found
R2732	T4493	T4494	advmod	Furthermore,found
R2733	T4495	T4494	nsubj	we,found
R2734	T4496	T4497	mark	that,responded
R2735	T4497	T4494	ccomp	responded,found
R2736	T4498	T4499	amod	murine,platelets
R2737	T4499	T4497	nsubj	platelets,responded
R2738	T4500	T4497	advmod	immediately,responded
R2739	T4501	T4497	prep	to,responded
R2740	T4502	T4503	det	the,chemical
R2741	T4503	T4501	pobj	chemical,to
R2742	T4504	T4503	amod	initiating,chemical
R2743	T4505	T4506	mark	whereas,have
R2744	T4506	T4497	advcl	have,responded
R2745	T4507	T4508	amod	human,platelets
R2746	T4508	T4506	nsubj	platelets,have
R2747	T4509	T4510	det	a,phase
R2748	T4510	T4506	dobj	phase,have
R2749	T4511	T4510	compound	lag,phase
R2750	T4512	T4513	punct	[,23
R2751	T4513	T4494	parataxis	23,found
R2752	T4514	T4513	punct	],23
R2753	T4515	T4494	punct	.,found
R2766	T5213	T5214	compound	Annexin,A7
R2767	T5214	T5215	nsubjpass	A7,thought
R2768	T5216	T5215	auxpass	is,thought
R2769	T5217	T5218	aux	to,have
R2770	T5218	T5215	xcomp	have,thought
R2771	T5219	T5220	det	a,role
R2772	T5220	T5218	dobj	role,have
R2773	T5221	T5218	prep	in,have
R2774	T5222	T5223	compound	vesicle,fusion
R2775	T5223	T5221	pobj	fusion,in
R2776	T5224	T5221	cc	and,in
R2777	T5225	T5221	conj	in,in
R2778	T5226	T5225	pcomp	regulating,in
R2779	T5227	T5226	cc	and,regulating
R2780	T5228	T5226	conj	stabilizing,regulating
R2781	T5229	T5230	compound	membrane,domains
R2782	T5230	T5228	dobj	domains,stabilizing
R2783	T5231	T5232	punct	[,1
R2784	T5232	T5215	parataxis	1,thought
R2785	T5233	T5232	punct	],1
R2786	T5234	T5215	punct	.,thought
R2787	T5236	T5237	det	The,protein
R2788	T5237	T5238	nsubjpass	protein,localized
R2789	T5238	T5241	ccomp	localized,is
R2790	T5239	T5238	aux	has,localized
R2791	T5240	T5238	auxpass	been,localized
R2792	T5242	T5238	prep	to,localized
R2793	T5243	T5244	det	the,membrane
R2794	T5244	T5242	pobj	membrane,to
R2795	T5245	T5244	compound	plasma,membrane
R2796	T5246	T5244	prep	including,membrane
R2797	T5247	T5248	compound	raft,subdomains
R2798	T5248	T5246	pobj	subdomains,including
R2799	T5249	T5241	punct	", ",is
R2800	T5250	T5241	advmod	furthermore,is
R2801	T5251	T5241	nsubj	it,is
R2802	T5252	T5241	acomp	present,is
R2803	T5253	T5241	prep	in,is
R2804	T5254	T5255	det	the,cytosol
R2805	T5255	T5253	pobj	cytosol,in
R2806	T5256	T5257	advmod	where,found
R2807	T5257	T5255	relcl	found,cytosol
R2808	T5258	T5257	nsubjpass	it,found
R2809	T5259	T5257	auxpass	is,found
R2810	T5260	T5257	prep	on,found
R2811	T5261	T5262	amod	subcellular,structures
R2812	T5262	T5260	pobj	structures,on
R2813	T5263	T5264	npadvmod	vesicle,like
R2814	T5264	T5262	amod	like,structures
R2815	T5265	T5264	punct	-,like
R2816	T5266	T5241	punct	.,is
R2817	T5268	T5269	det	This,distribution
R2818	T5269	T5270	nsubj	distribution,appears
R2819	T5271	T5272	aux	to,be
R2820	T5272	T5270	xcomp	be,appears
R2821	T5273	T5272	acomp	independent,be
R2822	T5274	T5273	prep	of,independent
R2823	T5275	T5276	det	the,type
R2824	T5276	T5274	pobj	type,of
R2825	T5277	T5276	nmod	tissue,type
R2826	T5278	T5277	cc	or,tissue
R2827	T5279	T5277	conj	cell,tissue
R2828	T5280	T5276	acl	analysed,type
R2829	T5281	T5270	punct	.,appears
R2830	T5283	T5284	prep	In,increase
R2831	T5285	T5286	amod	specialized,cells
R2832	T5286	T5283	pobj	cells,In
R2833	T5287	T5285	cc	or,specialized
R2834	T5288	T5289	advmod	terminally,differentiated
R2835	T5289	T5285	conj	differentiated,specialized
R2836	T5290	T5284	punct	", ",increase
R2837	T5291	T5292	compound	expression,levels
R2838	T5292	T5284	nsubj	levels,increase
R2839	T5293	T5284	cc	and,increase
R2840	T5294	T5295	advmod	frequently,expressed
R2841	T5295	T5284	conj	expressed,increase
R2842	T5296	T5297	det	the,larger
R2843	T5297	T5295	nsubjpass	larger,expressed
R2844	T5298	T5297	prep	of,larger
R2845	T5299	T5300	det	the,isoforms
R2846	T5300	T5298	pobj	isoforms,of
R2847	T5301	T5300	nummod	two,isoforms
R2848	T5302	T5295	aux	is,expressed
R2849	T5303	T5295	auxpass	being,expressed
R2850	T5304	T5305	punct	[,35
R2851	T5305	T5295	parataxis	35,expressed
R2852	T5306	T5305	nummod	6,35
R2853	T5307	T5305	punct	",",35
R2854	T5308	T5305	nummod	34,35
R2855	T5309	T5305	punct	",",35
R2856	T5310	T5305	punct	],35
R2857	T5311	T5284	punct	.,increase
R2858	T5313	T5314	amod	Red,cells
R2859	T5314	T5316	nsubjpass	cells,shown
R2860	T5315	T5314	compound	blood,cells
R2861	T5317	T5314	punct	", ",cells
R2862	T5318	T5319	dep	which,thought
R2863	T5319	T5314	relcl	thought,cells
R2864	T5320	T5319	auxpass	were,thought
R2865	T5321	T5322	aux	to,be
R2866	T5322	T5319	xcomp	be,thought
R2867	T5323	T5322	acomp	devoid,be
R2868	T5324	T5323	prep	of,devoid
R2869	T5325	T5326	compound	annexin,A7
R2870	T5326	T5324	pobj	A7,of
R2871	T5327	T5316	punct	", ",shown
R2872	T5328	T5316	auxpass	were,shown
R2873	T5329	T5316	advmod	recently,shown
R2874	T5330	T5331	aux	to,harbor
R2875	T5331	T5316	xcomp	harbor,shown
R2876	T5332	T5333	det	the,isoform
R2877	T5333	T5331	dobj	isoform,harbor
R2878	T5334	T5335	nummod	47,kDa
R2879	T5335	T5333	compound	kDa,isoform
R2880	T5336	T5337	advmod	together,with
R2881	T5337	T5333	prep	with,isoform
R2882	T5338	T5339	poss	its,partner
R2883	T5339	T5337	pobj	partner,with
R2884	T5340	T5339	amod	binding,partner
R2885	T5341	T5339	appos	sorcin,partner
R2886	T5342	T5343	punct	[,7
R2887	T5343	T5316	parataxis	7,shown
R2888	T5344	T5343	punct	],7
R2889	T5345	T5316	punct	.,shown
R2890	T5347	T5348	nsubj	We,showed
R2891	T5349	T5350	det	the,presence
R2892	T5350	T5348	dobj	presence,showed
R2893	T5351	T5350	prep	of,presence
R2894	T5352	T5353	det	the,isoform
R2895	T5353	T5351	pobj	isoform,of
R2896	T5354	T5355	nummod	51,kDa
R2897	T5355	T5353	compound	kDa,isoform
R2898	T5356	T5357	advmod	as,well
R2899	T5357	T5348	advmod	well,showed
R2900	T5358	T5348	punct	", ",showed
R2901	T5359	T5348	advcl	adding,showed
R2902	T5360	T5361	amod	red,cells
R2903	T5361	T5359	dobj	cells,adding
R2904	T5362	T5361	compound	blood,cells
R2905	T5363	T5359	prep	to,adding
R2906	T5364	T5365	det	the,list
R2907	T5365	T5363	pobj	list,to
R2908	T5366	T5365	prep	of,list
R2909	T5367	T5366	pobj	cells,of
R2910	T5368	T5369	dep	that,harbor
R2911	T5369	T5367	relcl	harbor,cells
R2912	T5370	T5371	det	this,isoform
R2913	T5371	T5369	dobj	isoform,harbor
R2914	T5372	T5348	punct	.,showed
R2915	T5374	T5375	ccomp	Salzer,showed
R2916	T5376	T5377	advmod	et,al.
R2917	T5377	T5374	advmod	al.,Salzer
R2918	T5378	T5379	punct	[,7
R2919	T5379	T5374	parataxis	7,Salzer
R2920	T5380	T5379	punct	],7
R2921	T5381	T5374	preconj	not,Salzer
R2922	T5382	T5381	advmod	only,not
R2923	T5383	T5374	conj	demonstrated,Salzer
R2924	T5384	T5385	det	the,presence
R2925	T5385	T5383	dobj	presence,demonstrated
R2926	T5386	T5385	prep	of,presence
R2927	T5387	T5388	compound	annexin,A7
R2928	T5388	T5386	pobj	A7,of
R2929	T5389	T5383	prep	in,demonstrated
R2930	T5390	T5391	amod	red,cells
R2931	T5391	T5389	pobj	cells,in
R2932	T5392	T5391	compound	blood,cells
R2933	T5393	T5375	punct	", ",showed
R2934	T5394	T5375	nsubj	they,showed
R2935	T5395	T5375	advmod	also,showed
R2936	T5396	T5397	mark	that,were
R2937	T5397	T5375	ccomp	were,showed
R2938	T5398	T5399	compound	annexin,A7
R2939	T5399	T5397	nsubj	A7,were
R2940	T5400	T5399	cc	and,A7
R2941	T5401	T5399	conj	sorcin,A7
R2942	T5402	T5397	acomp	enriched,were
R2943	T5403	T5397	prep	in,were
R2944	T5404	T5405	compound	membrane,raft
R2945	T5405	T5406	compound	raft,domains
R2946	T5406	T5403	pobj	domains,in
R2947	T5407	T5406	prep	of,domains
R2948	T5408	T5407	pobj	nanovesicles,of
R2949	T5409	T5408	acl	formed,nanovesicles
R2950	T5410	T5409	prep	from,formed
R2951	T5411	T5412	amod	red,cells
R2952	T5412	T5410	pobj	cells,from
R2953	T5413	T5412	compound	blood,cells
R2954	T5414	T5415	advmod	in,vitro
R2955	T5415	T5409	advmod	vitro,formed
R2956	T5416	T5375	punct	.,showed
R2957	T5418	T5419	compound	Raft,domains
R2958	T5419	T5420	nsubjpass	domains,considered
R2959	T5421	T5420	prep	in,considered
R2960	T5422	T5421	amod	general,in
R2961	T5423	T5420	auxpass	are,considered
R2962	T5424	T5425	amod	key,players
R2963	T5425	T5420	oprd	players,considered
R2964	T5426	T5425	prep	in,players
R2965	T5427	T5428	compound	membrane,organization
R2966	T5428	T5426	pobj	organization,in
R2967	T5429	T5426	cc	and,in
R2968	T5430	T5426	conj	in,in
R2969	T5431	T5430	pcomp	mediating,in
R2970	T5432	T5433	det	the,process
R2971	T5433	T5431	dobj	process,mediating
R2972	T5434	T5433	compound	vesiculation,process
R2973	T5435	T5420	punct	.,considered
R2974	T5437	T5438	nsubj	They,result
R2975	T5439	T5438	prep	from,result
R2976	T5440	T5441	det	the,clustering
R2977	T5441	T5439	pobj	clustering,from
R2978	T5442	T5441	prep	of,clustering
R2979	T5443	T5442	pobj	sphingolipids,of
R2980	T5444	T5443	cc	and,sphingolipids
R2981	T5445	T5443	conj	cholesterol,sphingolipids
R2982	T5446	T5441	prep	in,clustering
R2983	T5447	T5448	det	the,leaflet
R2984	T5448	T5446	pobj	leaflet,in
R2985	T5449	T5448	amod	outer,leaflet
R2986	T5450	T5448	prep	of,leaflet
R2987	T5451	T5452	det	the,membrane
R2988	T5452	T5450	pobj	membrane,of
R2989	T5453	T5452	acl	connected,membrane
R2990	T5454	T5453	prep	to,connected
R2991	T5455	T5454	pobj	phospholipids,to
R2992	T5456	T5455	cc	and,phospholipids
R2993	T5457	T5455	conj	cholesterol,phospholipids
R2994	T5458	T5453	prep	in,connected
R2995	T5459	T5460	det	the,leaflet
R2996	T5460	T5458	pobj	leaflet,in
R2997	T5461	T5460	amod	inner,leaflet
R2998	T5462	T5438	cc	and,result
R2999	T5463	T5438	conj	are,result
R3000	T5464	T5463	acomp	enriched,are
R3001	T5465	T5463	prep	in,are
R3002	T5466	T5467	amod	special,proteins
R3003	T5467	T5465	pobj	proteins,in
R3004	T5468	T5438	punct	.,result
R3005	T5470	T5471	advmod	Biochemically,defined
R3006	T5472	T5471	nsubjpass	rafts,defined
R3007	T5473	T5471	auxpass	are,defined
R3008	T5474	T5471	prep	as,defined
R3009	T5475	T5474	pobj	membranes,as
R3010	T5476	T5477	dep	that,are
R3011	T5477	T5475	relcl	are,membranes
R3012	T5478	T5477	acomp	resistant,are
R3013	T5479	T5478	prep	to,resistant
R3014	T5480	T5479	pobj	extraction,to
R3015	T5481	T5480	prep	by,extraction
R3016	T5482	T5483	amod	cold,X
R3017	T5483	T5481	pobj	X,by
R3018	T5484	T5483	compound	Triton,X
R3019	T5485	T5483	punct	-,X
R3020	T5486	T5483	nummod	100,X
R3021	T5487	T5471	cc	and,defined
R3022	T5488	T5489	aux	can,floated
R3023	T5489	T5471	conj	floated,defined
R3024	T5490	T5489	auxpass	be,floated
R3025	T5491	T5489	prep	to,floated
R3026	T5492	T5493	amod	low,densities
R3027	T5493	T5491	pobj	densities,to
R3028	T5494	T5489	prep	in,floated
R3029	T5495	T5496	compound	sucrose,gradient
R3030	T5496	T5497	compound	gradient,centrifugation
R3031	T5497	T5494	pobj	centrifugation,in
R3032	T5498	T5499	punct	[,36
R3033	T5499	T5489	parataxis	36,floated
R3034	T5500	T5499	punct	],36
R3035	T5501	T5471	punct	.,defined
R3036	T5503	T5504	det	The,findings
R3037	T5504	T5505	nsubj	findings,suggested
R3038	T5506	T5504	prep	of,findings
R3039	T5507	T5506	pobj	Caohuy,of
R3040	T5508	T5509	advmod	et,al.
R3041	T5509	T5507	advmod	al.,Caohuy
R3042	T5510	T5511	punct	[,37
R3043	T5511	T5507	parataxis	37,Caohuy
R3044	T5512	T5511	punct	],37
R3045	T5513	T5514	mark	that,mediates
R3046	T5514	T5504	acl	mediates,findings
R3047	T5515	T5516	compound	annexin,A7
R3048	T5516	T5514	nsubj	A7,mediates
R3049	T5517	T5518	compound	membrane,aggregation
R3050	T5518	T5514	dobj	aggregation,mediates
R3051	T5519	T5505	advmod	also,suggested
R3052	T5520	T5521	mark	that,is
R3053	T5521	T5505	ccomp	is,suggested
R3054	T5522	T5523	compound	annexin,A7
R3055	T5523	T5521	nsubj	A7,is
R3056	T5524	T5525	det	an,component
R3057	T5525	T5521	attr	component,is
R3058	T5526	T5525	amod	essential,component
R3059	T5527	T5521	prep	during,is
R3060	T5528	T5527	pobj	vesiculation,during
R3061	T5529	T5505	punct	.,suggested
R3062	T5531	T5532	prep	In,reported
R3063	T5533	T5531	pobj	addition,In
R3064	T5534	T5532	nsubj	they,reported
R3065	T5535	T5536	det	a,activation
R3066	T5536	T5532	dobj	activation,reported
R3067	T5537	T5536	amod	further,activation
R3068	T5538	T5536	prep	of,activation
R3069	T5539	T5540	det	the,process
R3070	T5540	T5538	pobj	process,of
R3071	T5541	T5540	compound	vesiculation,process
R3072	T5542	T5536	prep	by,activation
R3073	T5543	T5542	pobj	GTP,by
R3074	T5544	T5532	cc	and,reported
R3075	T5545	T5532	conj	proposed,reported
R3076	T5546	T5547	mark	that,acts
R3077	T5547	T5545	ccomp	acts,proposed
R3078	T5548	T5549	compound	annexin,A7
R3079	T5549	T5547	nsubj	A7,acts
R3080	T5550	T5547	prep	as,acts
R3081	T5551	T5552	det	a,GTPase
R3082	T5552	T5550	pobj	GTPase,as
R3083	T5553	T5532	punct	.,reported
R3084	T5555	T5556	advmod	Similarly,enhanced
R3085	T5557	T5556	punct	", ",enhanced
R3086	T5558	T5559	det	the,presence
R3087	T5559	T5556	nsubj	presence,enhanced
R3088	T5560	T5559	prep	of,presence
R3089	T5561	T5560	pobj	GTP,of
R3090	T5562	T5563	det	the,secretion
R3091	T5563	T5556	dobj	secretion,enhanced
R3092	T5564	T5563	prep	of,secretion
R3093	T5565	T5564	pobj	surfactant,of
R3094	T5566	T5563	prep	by,secretion
R3095	T5567	T5568	compound	annexin,A7
R3096	T5568	T5566	pobj	A7,by
R3097	T5569	T5556	punct	.,enhanced
R3098	T5571	T5572	det	These,results
R3099	T5572	T5573	nsubjpass	results,thought
R3100	T5574	T5573	auxpass	were,thought
R3101	T5575	T5576	aux	to,support
R3102	T5576	T5573	xcomp	support,thought
R3103	T5577	T5578	det	a,role
R3104	T5578	T5576	dobj	role,support
R3105	T5579	T5578	amod	direct,role
R3106	T5580	T5578	prep	for,role
R3107	T5581	T5582	compound	annexin,A7
R3108	T5582	T5580	pobj	A7,for
R3109	T5583	T5578	prep	in,role
R3110	T5584	T5585	amod	surfactant,secretion
R3111	T5585	T5583	pobj	secretion,in
R3112	T5586	T5573	punct	", ",thought
R3113	T5587	T5573	cc	but,thought
R3114	T5588	T5589	prep	in,separated
R3115	T5589	T5573	conj	separated,thought
R3116	T5590	T5591	det	these,studies
R3117	T5591	T5588	pobj	studies,in
R3118	T5592	T5593	compound	annexin,A7
R3119	T5593	T5594	npadvmod	A7,mediated
R3120	T5594	T5595	amod	mediated,fusion
R3121	T5595	T5589	nsubjpass	fusion,separated
R3122	T5596	T5595	compound	membrane,fusion
R3123	T5597	T5589	auxpass	was,separated
R3124	T5598	T5589	prep	from,separated
R3125	T5599	T5600	det	a,mechanism
R3126	T5600	T5598	pobj	mechanism,from
R3127	T5601	T5600	amod	second,mechanism
R3128	T5602	T5603	npadvmod	GTP,dependent
R3129	T5603	T5600	amod	dependent,mechanism
R3130	T5604	T5603	punct	-,dependent
R3131	T5605	T5606	punct	[,38
R3132	T5606	T5589	parataxis	38,separated
R3133	T5607	T5606	punct	],38
R3134	T5608	T5589	punct	.,separated
R3135	T5610	T5611	advcl	Having,tested
R3136	T5612	T5613	det	an,mouse
R3137	T5613	T5610	dobj	mouse,Having
R3138	T5614	T5615	compound	annexin,A7
R3139	T5615	T5613	compound	A7,mouse
R3140	T5616	T5613	compound	knockout,mouse
R3141	T5617	T5611	nsubj	we,tested
R3142	T5618	T5619	det	the,involvement
R3143	T5619	T5611	dobj	involvement,tested
R3144	T5620	T5619	prep	of,involvement
R3145	T5621	T5622	compound	annexin,A7
R3146	T5622	T5620	pobj	A7,of
R3147	T5623	T5619	prep	in,involvement
R3148	T5624	T5623	pobj	budding,in
R3149	T5625	T5624	prep	of,budding
R3150	T5626	T5627	amod	red,cell
R3151	T5627	T5629	compound	cell,vesicles
R3152	T5628	T5627	compound	blood,cell
R3153	T5629	T5625	pobj	vesicles,of
R3154	T5630	T5611	punct	.,tested
R3155	T5632	T5633	poss	Our,data
R3156	T5633	T5634	nsubj	data,suggest
R3157	T5635	T5636	mark	that,is
R3158	T5636	T5634	ccomp	is,suggest
R3159	T5637	T5638	det	the,efficiency
R3160	T5638	T5636	nsubj	efficiency,is
R3161	T5639	T5638	prep	of,efficiency
R3162	T5640	T5641	nmod	micro,nanovesicle
R3163	T5641	T5644	compound	nanovesicle,formation
R3164	T5642	T5641	punct	-,nanovesicle
R3165	T5643	T5641	cc	and,nanovesicle
R3166	T5644	T5639	pobj	formation,of
R3167	T5645	T5636	neg	not,is
R3168	T5646	T5647	advmod	significantly,different
R3169	T5647	T5636	acomp	different,is
R3170	T5648	T5636	prep	in,is
R3171	T5649	T5650	amod	wild,type
R3172	T5650	T5651	nmod	type,cells
R3173	T5651	T5648	pobj	cells,in
R3174	T5652	T5650	cc	and,type
R3175	T5653	T5650	conj	mutant,type
R3176	T5654	T5651	amod	red,cells
R3177	T5655	T5651	compound	blood,cells
R3178	T5656	T5634	punct	.,suggest
R3179	T5658	T5659	advmod	Likewise,were
R3180	T5660	T5659	punct	", ",were
R3181	T5661	T5662	compound	Dictyostelium,discoideum
R3182	T5662	T5663	compound	discoideum,cells
R3183	T5663	T5659	nsubj	cells,were
R3184	T5664	T5663	punct	", ",cells
R3185	T5665	T5666	prep	in,was
R3186	T5666	T5663	relcl	was,cells
R3187	T5667	T5665	pobj	which,in
R3188	T5668	T5669	det	the,gene
R3189	T5669	T5666	nsubj	gene,was
R3190	T5670	T5669	amod	single,gene
R3191	T5671	T5669	compound	annexin,gene
R3192	T5672	T5666	acomp	inactivated,was
R3193	T5673	T5659	punct	", ",were
R3194	T5674	T5659	neg	not,were
R3195	T5675	T5659	acomp	impaired,were
R3196	T5676	T5675	prep	in,impaired
R3197	T5677	T5676	pobj	processes,in
R3198	T5678	T5677	acl	requiring,processes
R3199	T5679	T5680	compound	membrane,fusion
R3200	T5680	T5678	dobj	fusion,requiring
R3201	T5681	T5682	punct	[,39
R3202	T5682	T5659	parataxis	39,were
R3203	T5683	T5682	punct	[,39
R3204	T5684	T5682	punct	],39
R3205	T5685	T5682	punct	;,39
R3206	T5686	T5682	cc	and,39
R3207	T5687	T5682	conj	data,39
R3208	T5688	T5687	amod	unpublished,data
R3209	T5689	T5687	punct	],data
R3210	T5690	T5659	punct	.,were
R3211	T5692	T5693	nsubj	It,be
R3212	T5694	T5693	aux	might,be
R3213	T5695	T5693	advmod	well,be
R3214	T5696	T5697	mark	that,turn
R3215	T5697	T5693	ccomp	turn,be
R3216	T5698	T5699	det	the,fusion
R3217	T5699	T5697	nsubj	fusion,turn
R3218	T5700	T5699	amod	observed,fusion
R3219	T5701	T5699	prep	of,fusion
R3220	T5702	T5703	compound	phospholipid,layers
R3221	T5703	T5701	pobj	layers,of
R3222	T5704	T5699	prep	by,fusion
R3223	T5705	T5706	compound	annexin,A7
R3224	T5706	T5704	pobj	A7,by
R3225	T5707	T5699	prep	in,fusion
R3226	T5708	T5709	det	the,presence
R3227	T5709	T5707	pobj	presence,in
R3228	T5710	T5709	prep	of,presence
R3229	T5711	T5712	amod	high,concentrations
R3230	T5712	T5710	pobj	concentrations,of
R3231	T5713	T5712	compound	Ca2+,concentrations
R3232	T5714	T5697	aux	may,turn
R3233	T5715	T5697	prt	out,turn
R3234	T5716	T5717	aux	to,be
R3235	T5717	T5697	xcomp	be,turn
R3236	T5718	T5719	det	an,effect
R3237	T5719	T5717	attr	effect,be
R3238	T5720	T5721	advmod	in,vitro
R3239	T5721	T5719	amod	vitro,effect
R3240	T5722	T5693	punct	.,be
R3241	T5724	T5725	advmod	Similarly,be
R3242	T5726	T5725	punct	", ",be
R3243	T5727	T5728	det	the,abundance
R3244	T5728	T5725	nsubj	abundance,be
R3245	T5729	T5728	amod	high,abundance
R3246	T5730	T5728	prep	of,abundance
R3247	T5731	T5732	compound	annexin,A7
R3248	T5732	T5730	pobj	A7,of
R3249	T5733	T5728	prep	in,abundance
R3250	T5734	T5735	nmod	micro,nanovesicles
R3251	T5735	T5733	pobj	nanovesicles,in
R3252	T5736	T5735	punct	-,nanovesicles
R3253	T5737	T5735	cc	and,nanovesicles
R3254	T5738	T5725	aux	might,be
R3255	T5739	T5725	acomp	fortuitous,be
R3256	T5740	T5741	mark	as,appears
R3257	T5741	T5725	advcl	appears,be
R3258	T5742	T5743	det	a,percentage
R3259	T5743	T5741	nsubj	percentage,appears
R3260	T5744	T5743	amod	significant,percentage
R3261	T5745	T5743	prep	of,percentage
R3262	T5746	T5747	det	the,membrane
R3263	T5747	T5745	pobj	membrane,of
R3264	T5748	T5749	amod	red,cell
R3265	T5749	T5747	compound	cell,membrane
R3266	T5750	T5749	compound	blood,cell
R3267	T5751	T5747	punct	", ",membrane
R3268	T5752	T5753	prep	with,associates
R3269	T5753	T5747	relcl	associates,membrane
R3270	T5754	T5752	pobj	which,with
R3271	T5755	T5756	compound	annexin,A7
R3272	T5756	T5753	nsubj	A7,associates
R3273	T5757	T5758	advmod	when,rise
R3274	T5758	T5753	advcl	rise,associates
R3275	T5759	T5760	det	the,levels
R3276	T5760	T5758	nsubj	levels,rise
R3277	T5761	T5760	compound	Ca2+,levels
R3278	T5762	T5741	punct	", ",appears
R3279	T5763	T5764	aux	to,involved
R3280	T5764	T5741	xcomp	involved,appears
R3281	T5765	T5764	auxpass	be,involved
R3282	T5766	T5764	prep	in,involved
R3283	T5767	T5768	det	the,formation
R3284	T5768	T5766	pobj	formation,in
R3285	T5769	T5768	prep	of,formation
R3286	T5770	T5769	pobj	exovesicles,of
R3287	T5771	T5725	punct	.,be
R3288	T5773	T5774	advmod	Furthermore,indicates
R3289	T5775	T5774	punct	", ",indicates
R3290	T5776	T5777	det	the,distribution
R3291	T5777	T5774	nsubj	distribution,indicates
R3292	T5778	T5777	prep	of,distribution
R3293	T5779	T5780	det	both,isoforms
R3294	T5780	T5778	pobj	isoforms,of
R3295	T5781	T5782	compound	annexin,A7
R3296	T5782	T5780	compound	A7,isoforms
R3297	T5783	T5777	prep	in,distribution
R3298	T5784	T5783	pobj	gradients,in
R3299	T5785	T5784	prep	of,gradients
R3300	T5786	T5787	amod	red,cells
R3301	T5787	T5785	pobj	cells,of
R3302	T5788	T5787	compound	blood,cells
R3303	T5789	T5790	det	a,function
R3304	T5790	T5774	dobj	function,indicates
R3305	T5791	T5792	dep	which,differs
R3306	T5792	T5790	relcl	differs,function
R3307	T5793	T5792	prep	from,differs
R3308	T5794	T5793	pcomp	organizing,from
R3309	T5795	T5796	amod	subcellular,membranes
R3310	T5796	T5794	dobj	membranes,organizing
R3311	T5797	T5796	cc	or,membranes
R3312	T5798	T5799	compound	membrane,pathways
R3313	T5799	T5796	conj	pathways,membranes
R3314	T5800	T5774	punct	.,indicates
R3315	T5802	T5803	mark	Whereas,associated
R3316	T5803	T5808	advcl	associated,distributes
R3317	T5804	T5805	compound	annexin,A2
R3318	T5805	T5803	nsubjpass	A2,associated
R3319	T5806	T5803	auxpass	is,associated
R3320	T5807	T5803	advmod	tightly,associated
R3321	T5809	T5803	prep	with,associated
R3322	T5810	T5809	pobj	endosomes,with
R3323	T5811	T5803	cc	and,associated
R3324	T5812	T5813	aux	may,have
R3325	T5813	T5803	conj	have,associated
R3326	T5814	T5813	dobj	functions,have
R3327	T5815	T5813	prep	in,have
R3328	T5816	T5817	compound	membrane,fusion
R3329	T5817	T5815	pobj	fusion,in
R3330	T5818	T5817	cc	and,fusion
R3331	T5819	T5820	det	the,pathway
R3332	T5820	T5817	conj	pathway,fusion
R3333	T5821	T5820	amod	endosomal,pathway
R3334	T5822	T5808	punct	", ",distributes
R3335	T5823	T5824	compound	annexin,A7
R3336	T5824	T5808	nsubj	A7,distributes
R3337	T5825	T5808	prep	with,distributes
R3338	T5826	T5827	compound	plasma,membrane
R3339	T5827	T5828	compound	membrane,domains
R3340	T5828	T5825	pobj	domains,with
R3341	T5829	T5828	compound	raft,domains
R3342	T5830	T5828	prep	of,domains
R3343	T5831	T5832	amod	different,types
R3344	T5832	T5830	pobj	types,of
R3345	T5833	T5832	cc	and,types
R3346	T5834	T5832	conj	densities,types
R3347	T5835	T5808	punct	.,distributes
R3348	T5837	T5838	advmod	Interestingly,lowered
R3349	T5839	T5838	punct	", ",lowered
R3350	T5840	T5838	prep	in,lowered
R3351	T5841	T5840	pobj	vesicles,in
R3352	T5842	T5841	prep	of,vesicles
R3353	T5843	T5844	amod	red,cells
R3354	T5844	T5842	pobj	cells,of
R3355	T5845	T5844	compound	blood,cells
R3356	T5846	T5844	acl	lacking,cells
R3357	T5847	T5848	compound	annexin,A7
R3358	T5848	T5846	dobj	A7,lacking
R3359	T5849	T5850	det	the,amount
R3360	T5850	T5838	nsubjpass	amount,lowered
R3361	T5851	T5850	prep	of,amount
R3362	T5852	T5851	pobj	sorcin,of
R3363	T5853	T5838	auxpass	is,lowered
R3364	T5854	T5838	punct	", ",lowered
R3365	T5855	T5838	advcl	indicating,lowered
R3366	T5856	T5857	mark	that,affected
R3367	T5857	T5855	ccomp	affected,indicating
R3368	T5858	T5859	poss	its,localisation
R3369	T5859	T5857	nsubjpass	localisation,affected
R3370	T5860	T5857	auxpass	is,affected
R3371	T5861	T5857	agent	by,affected
R3372	T5862	T5863	det	the,loss
R3373	T5863	T5861	pobj	loss,by
R3374	T5864	T5863	prep	of,loss
R3375	T5865	T5866	compound	annexin,A7
R3376	T5866	T5864	pobj	A7,of
R3377	T5867	T5857	cc	or,affected
R3378	T5868	T5869	poss	its,expression
R3379	T5869	T5870	nsubjpass	expression,reduced
R3380	T5870	T5857	conj	reduced,affected
R3381	T5871	T5869	prep	during,expression
R3382	T5872	T5873	amod	red,cell
R3383	T5873	T5875	compound	cell,development
R3384	T5874	T5873	compound	blood,cell
R3385	T5875	T5871	pobj	development,during
R3386	T5876	T5870	auxpass	was,reduced
R3387	T5877	T5838	punct	.,lowered
R3388	T5879	T5880	aux	Having,excluded
R3389	T5880	T5881	advcl	excluded,act
R3390	T5882	T5883	det	a,role
R3391	T5883	T5880	dobj	role,excluded
R3392	T5884	T5883	amod	direct,role
R3393	T5885	T5883	prep	in,role
R3394	T5886	T5887	compound	vesicle,formation
R3395	T5887	T5885	pobj	formation,in
R3396	T5888	T5887	cc	and,formation
R3397	T5889	T5890	compound	membrane,fusion
R3398	T5890	T5887	conj	fusion,formation
R3399	T5891	T5881	punct	", ",act
R3400	T5892	T5893	compound	annexin,A7
R3401	T5893	T5881	nsubj	A7,act
R3402	T5894	T5881	aux	might,act
R3403	T5895	T5881	prep	by,act
R3404	T5896	T5897	poss	its,property
R3405	T5897	T5895	pobj	property,by
R3406	T5898	T5897	prep	as,property
R3407	T5899	T5900	npadvmod	Ca2+,binding
R3408	T5900	T5902	amod	binding,protein
R3409	T5901	T5900	punct	-,binding
R3410	T5902	T5898	pobj	protein,as
R3411	T5903	T5904	punct	[,17
R3412	T5904	T5881	parataxis	17,act
R3413	T5905	T5904	punct	],17
R3414	T5906	T5881	punct	.,act
R3415	T5908	T5909	amod	Previous,results
R3416	T5909	T5910	nsubjpass	results,explained
R3417	T5911	T5912	prep	in,shown
R3418	T5912	T5909	relcl	shown,results
R3419	T5913	T5911	pobj	which,in
R3420	T5914	T5915	compound	annexin,A7
R3421	T5915	T5912	nsubjpass	A7,shown
R3422	T5916	T5912	auxpass	was,shown
R3423	T5917	T5918	aux	to,play
R3424	T5918	T5912	xcomp	play,shown
R3425	T5919	T5920	det	a,role
R3426	T5920	T5918	dobj	role,play
R3427	T5921	T5918	prep	in,play
R3428	T5922	T5923	compound	membrane,aggregation
R3429	T5923	T5921	pobj	aggregation,in
R3430	T5924	T5910	aux	might,explained
R3431	T5925	T5910	auxpass	be,explained
R3432	T5926	T5910	agent	by,explained
R3433	T5927	T5928	det	a,function
R3434	T5928	T5926	pobj	function,by
R3435	T5929	T5928	amod	supportive,function
R3436	T5930	T5928	prep	of,function
R3437	T5931	T5932	compound	annexin,A7
R3438	T5932	T5930	pobj	A7,of
R3439	T5933	T5934	mark	in,interferes
R3440	T5934	T5910	advcl	interferes,explained
R3441	T5935	T5934	mark	that,interferes
R3442	T5936	T5934	nsubj	it,interferes
R3443	T5937	T5934	prep	with,interferes
R3444	T5938	T5939	det	the,homeostasis
R3445	T5939	T5937	pobj	homeostasis,with
R3446	T5940	T5939	amod	local,homeostasis
R3447	T5941	T5939	compound	Ca2+,homeostasis
R3448	T5942	T5943	advmod	thus,influencing
R3449	T5943	T5934	advcl	influencing,interferes
R3450	T5944	T5945	compound	membrane,organization
R3451	T5945	T5943	dobj	organization,influencing
R3452	T5946	T5910	punct	.,explained
R3453	T5948	T5949	mark	As,belong
R3454	T5949	T5952	advcl	belong,expected
R3455	T5950	T5951	det	the,annexins
R3456	T5951	T5949	nsubj	annexins,belong
R3457	T5953	T5949	prep	to,belong
R3458	T5954	T5955	det	a,family
R3459	T5955	T5953	pobj	family,to
R3460	T5956	T5957	advmod	wide,spread
R3461	T5957	T5955	amod	spread,family
R3462	T5958	T5957	cc	and,spread
R3463	T5959	T5960	advmod	evolutionarily,conserved
R3464	T5960	T5957	conj	conserved,spread
R3465	T5961	T5955	compound	protein,family
R3466	T5962	T5952	punct	", ",expected
R3467	T5963	T5964	npadvmod	redundant,identical
R3468	T5964	T5968	amod	identical,functions
R3469	T5965	T5964	punct	", ",identical
R3470	T5966	T5964	cc	but,identical
R3471	T5967	T5966	neg	not,but
R3472	T5968	T5952	nsubjpass	functions,expected
R3473	T5969	T5952	auxpass	are,expected
R3474	T5970	T5952	punct	.,expected
R3475	T5972	T5973	advmod	However,described
R3476	T5974	T5973	punct	", ",described
R3477	T5975	T5976	advmod	so,far
R3478	T5976	T5973	advmod	far,described
R3479	T5977	T5978	det	no,members
R3480	T5978	T5973	nsubjpass	members,described
R3481	T5979	T5978	amod	other,members
R3482	T5980	T5978	prep	of,members
R3483	T5981	T5982	det	the,family
R3484	T5982	T5980	pobj	family,of
R3485	T5983	T5982	compound	annexin,family
R3486	T5984	T5982	punct	", ",family
R3487	T5985	T5986	dep	which,substitute
R3488	T5986	T5982	relcl	substitute,family
R3489	T5987	T5986	aux	may,substitute
R3490	T5988	T5986	prep	for,substitute
R3491	T5989	T5990	compound	annexin,A7
R3492	T5990	T5988	pobj	A7,for
R3493	T5991	T5973	punct	", ",described
R3494	T5992	T5973	aux	have,described
R3495	T5993	T5973	auxpass	been,described
R3496	T5994	T5973	prep	in,described
R3497	T5995	T5996	amod	red,cells
R3498	T5996	T5994	pobj	cells,in
R3499	T5997	T5996	compound	blood,cells
R3500	T5998	T5973	punct	.,described
R3501	T6000	T6001	det	The,basis
R3502	T6001	T6003	nsubj	basis,are
R3503	T6002	T6001	amod	structural,basis
R3504	T6004	T6001	prep	for,basis
R3505	T6005	T6006	det	the,elasticy
R3506	T6006	T6004	pobj	elasticy,for
R3507	T6007	T6006	prep	of,elasticy
R3508	T6008	T6009	amod	red,cells
R3509	T6009	T6007	pobj	cells,of
R3510	T6010	T6009	compound	blood,cells
R3511	T6011	T6009	prep	in,cells
R3512	T6012	T6011	pobj	circulation,in
R3513	T6013	T6014	amod	long,range
R3514	T6014	T6015	nmod	range,functions
R3515	T6015	T6003	attr	functions,are
R3516	T6016	T6015	amod	molecular,functions
R3517	T6017	T6015	prep	of,functions
R3518	T6018	T6019	det	the,membrane
R3519	T6019	T6017	pobj	membrane,of
R3520	T6020	T6019	compound	plasma,membrane
R3521	T6021	T6019	cc	and,membrane
R3522	T6022	T6023	det	the,part
R3523	T6023	T6019	conj	part,membrane
R3524	T6024	T6025	npadvmod	membrane,associated
R3525	T6025	T6023	amod	associated,part
R3526	T6026	T6023	prep	of,part
R3527	T6027	T6028	det	the,cytoskeleton
R3528	T6028	T6026	pobj	cytoskeleton,of
R3529	T6029	T6030	punct	[,40
R3530	T6030	T6003	parataxis	40,are
R3531	T6031	T6032	punct	-,43
R3532	T6032	T6030	prep	43,40
R3533	T6033	T6030	punct	],40
R3534	T6034	T6003	punct	.,are
R3535	T6036	T6037	amod	Major,constituents
R3536	T6037	T6038	nsubj	constituents,are
R3537	T6039	T6037	prep	of,constituents
R3538	T6040	T6041	det	the,skeleton
R3539	T6041	T6039	pobj	skeleton,of
R3540	T6042	T6041	compound	membrane,skeleton
R3541	T6043	T6044	compound	spectrin,tetramers
R3542	T6044	T6038	attr	tetramers,are
R3543	T6045	T6044	acl	linked,tetramers
R3544	T6046	T6045	advmod	together,linked
R3545	T6047	T6045	agent	by,linked
R3546	T6048	T6049	amod	short,filaments
R3547	T6049	T6047	pobj	filaments,by
R3548	T6050	T6049	compound	actin,filaments
R3549	T6051	T6049	cc	and,filaments
R3550	T6052	T6053	amod	several,proteins
R3551	T6053	T6049	conj	proteins,filaments
R3552	T6054	T6053	amod	other,proteins
R3553	T6055	T6053	acl	covering,proteins
R3554	T6056	T6057	det	the,surface
R3555	T6057	T6055	dobj	surface,covering
R3556	T6058	T6057	amod	entire,surface
R3557	T6059	T6057	amod	cytoplasmic,surface
R3558	T6060	T6057	prep	of,surface
R3559	T6061	T6062	det	the,membrane
R3560	T6062	T6060	pobj	membrane,of
R3561	T6063	T6064	amod	red,cell
R3562	T6064	T6062	compound	cell,membrane
R3563	T6065	T6064	compound	blood,cell
R3564	T6066	T6067	punct	[,44
R3565	T6067	T6038	parataxis	44,are
R3566	T6068	T6067	punct	],44
R3567	T6069	T6038	punct	.,are
R3568	T6071	T6072	compound	Membrane,cholesterol
R3569	T6072	T6073	nsubj	cholesterol,diminishes
R3570	T6074	T6075	amod	red,cell
R3571	T6075	T6077	compound	cell,haemolysis
R3572	T6076	T6075	compound	blood,cell
R3573	T6077	T6073	dobj	haemolysis,diminishes
R3574	T6078	T6077	prep	by,haemolysis
R3575	T6079	T6080	det	the,complex
R3576	T6080	T6078	pobj	complex,by
R3577	T6081	T6080	compound	complement,complex
R3578	T6082	T6073	punct	", ",diminishes
R3579	T6083	T6084	mark	whereas,abrogates
R3580	T6084	T6073	advcl	abrogates,diminishes
R3581	T6085	T6084	nsubj	depletion,abrogates
R3582	T6086	T6085	prep	of,depletion
R3583	T6087	T6088	compound	raft,cholesterol
R3584	T6088	T6086	pobj	cholesterol,of
R3585	T6089	T6084	dobj	association,abrogates
R3586	T6090	T6089	prep	of,association
R3587	T6091	T6092	det	all,proteins
R3588	T6092	T6090	pobj	proteins,of
R3589	T6093	T6092	compound	raft,proteins
R3590	T6094	T6084	prep	with,abrogates
R3591	T6095	T6096	det	no,effect
R3592	T6132	T6130	dobj	resistance,have
R3593	T6096	T6094	pobj	effect,with
R3594	T6097	T6096	amod	significant,effect
R3595	T6098	T6096	prep	on,effect
R3596	T6133	T6132	amod	higher,resistance
R3597	T6099	T6098	pobj	areas,on
R3598	T6134	T6132	amod	osmotic,resistance
R3599	T6135	T6124	punct	.,show
R3600	T6100	T6099	prep	in,areas
R3601	T6137	T6138	det	The,presence
R3602	T6101	T6102	det	the,rest
R3603	T6138	T6139	nsubj	presence,alter
R3604	T6140	T6138	prep	of,presence
R3605	T6102	T6100	pobj	rest,in
R3606	T6141	T6142	compound	annexin,A7
R3607	T6142	T6140	pobj	A7,of
R3608	T6143	T6139	aux	may,alter
R3609	T6103	T6102	prep	of,rest
R3610	T6144	T6145	det	the,flexibility
R3611	T6145	T6139	dobj	flexibility,alter
R3612	T6104	T6105	det	the,membrane
R3613	T6146	T6145	compound	membrane,flexibility
R3614	T6147	T6148	mark	in,supports
R3615	T6148	T6139	advcl	supports,alter
R3616	T6105	T6103	pobj	membrane,of
R3617	T6149	T6148	mark	that,supports
R3618	T6150	T6148	nsubj	it,supports
R3619	T6106	T6105	compound	cell,membrane
R3620	T6151	T6152	det	the,shape
R3621	T6152	T6148	dobj	shape,supports
R3622	T6153	T6152	amod	typical,shape
R3623	T6107	T6099	cc	and,areas
R3624	T6154	T6152	compound	biconcave,shape
R3625	T6155	T6152	compound	membrane,shape
R3626	T6108	T6099	conj	deformability,areas
R3627	T6156	T6148	cc	and,supports
R3628	T6157	T6148	conj	leads,supports
R3629	T6158	T6157	prep	to,leads
R3630	T6159	T6160	det	a,resistance
R3631	T6109	T6110	punct	[,46
R3632	T6160	T6158	pobj	resistance,to
R3633	T6161	T6160	amod	lower,resistance
R3634	T6162	T6160	amod	minimal,resistance
R3635	T6163	T6160	amod	osmotic,resistance
R3636	T6110	T6073	parataxis	46,diminishes
R3637	T6164	T6139	punct	.,alter
R3638	T6166	T6167	compound	Annexin,A7
R3639	T6167	T6168	nsubj	A7,appear
R3640	T6111	T6110	nummod	45,46
R3641	T6169	T6168	aux	does,appear
R3642	T6170	T6168	neg	not,appear
R3643	T6112	T6110	punct	",",46
R3644	T6171	T6172	aux	to,have
R3645	T6172	T6168	xcomp	have,appear
R3646	T6173	T6174	det	an,influence
R3647	T6113	T6110	punct	],46
R3648	T6174	T6172	dobj	influence,have
R3649	T6175	T6174	prep	on,influence
R3650	T6114	T6073	punct	.,diminishes
R3651	T6176	T6177	compound	plasma,membrane
R3652	T6177	T6178	compound	membrane,integrity
R3653	T6178	T6175	pobj	integrity,on
R3654	T6116	T6117	nmod	Annexin,A7
R3655	T6179	T6178	appos	itself,integrity
R3656	T6180	T6181	mark	as,stays
R3657	T6181	T6172	advcl	stays,have
R3658	T6182	T6183	det	the,value
R3659	T6117	T6118	nmod	A7,cells
R3660	T6183	T6181	nsubj	value,stays
R3661	T6184	T6183	amod	maximal,value
R3662	T6185	T6186	amod	osmotic,resistance
R3663	T6118	T6124	nsubj	cells,show
R3664	T6186	T6183	compound	resistance,value
R3665	T6187	T6181	acomp	constant,stays
R3666	T6188	T6168	punct	.,appear
R3667	T6119	T6120	nmod	knock,out
R3668	T6190	T6191	nmod	Ca2+,proteins
R3669	T6120	T6121	nmod	out,mouse
R3670	T6191	T6195	nsubjpass	proteins,known
R3671	T6192	T6190	cc	and,Ca2+
R3672	T6193	T6194	npadvmod	membrane,skeletal
R3673	T6121	T6118	nmod	mouse,cells
R3674	T6194	T6190	conj	skeletal,Ca2+
R3675	T6122	T6118	amod	red,cells
R3676	T6196	T6195	auxpass	are,known
R3677	T6197	T6198	aux	to,play
R3678	T6198	T6195	xcomp	play,known
R3679	T6123	T6118	compound	blood,cells
R3680	T6199	T6200	amod	key,roles
R3681	T6200	T6198	dobj	roles,play
R3682	T6125	T6126	det	a,shape
R3683	T6201	T6198	prep	on,play
R3684	T6202	T6203	det	the,shape
R3685	T6203	T6201	pobj	shape,on
R3686	T6204	T6205	amod	red,cell
R3687	T6205	T6203	compound	cell,shape
R3688	T6206	T6205	compound	blood,cell
R3689	T6126	T6124	dobj	shape,show
R3690	T6127	T6128	advmod	more,flat
R3691	T6207	T6203	compound	membrane,shape
R3692	T6208	T6203	cc	and,shape
R3693	T6209	T6203	conj	stability,shape
R3694	T6128	T6126	amod	flat,shape
R3695	T6210	T6211	punct	[,47
R3696	T6211	T6195	parataxis	47,known
R3697	T6129	T6124	cc	and,show
R3698	T6212	T6211	punct	],47
R3699	T6213	T6195	punct	.,known
R3700	T6215	T6216	nsubjpass	Annexins,reported
R3701	T6130	T6124	conj	have,show
R3702	T6216	T6219	ccomp	reported,exclude
R3703	T6217	T6216	aux	have,reported
R3704	T6131	T6132	det	a,resistance
R3705	T6218	T6216	auxpass	been,reported
R3706	T6220	T6221	aux	to,bind
R3707	T6239	T6240	advmod	Nevertheless,interact
R3708	T6221	T6216	xcomp	bind,reported
R3709	T6222	T6221	advmod	directly,bind
R3710	T6223	T6221	prep	to,bind
R3711	T6224	T6225	compound	F,actin
R3712	T6225	T6223	pobj	actin,to
R3713	T6226	T6225	punct	-,actin
R3714	T6241	T6240	nsubj	it,interact
R3715	T6227	T6219	punct	", ",exclude
R3716	T6228	T6219	nsubj	we,exclude
R3717	T6229	T6219	aux	could,exclude
R3718	T6230	T6219	advmod	however,exclude
R3719	T6242	T6240	aux	might,interact
R3720	T6231	T6232	amod	such,activity
R3721	T6232	T6219	dobj	activity,exclude
R3722	T6243	T6240	prep	with,interact
R3723	T6233	T6232	det	an,activity
R3724	T6234	T6219	prep	for,exclude
R3725	T6244	T6245	amod	other,components
R3726	T6235	T6236	compound	annexin,A7
R3727	T6236	T6234	pobj	A7,for
R3728	T6237	T6219	punct	.,exclude
R3729	T6245	T6243	pobj	components,with
R3730	T6246	T6240	cc	and,interact
R3731	T6247	T6240	conj	have,interact
R3732	T6248	T6249	det	a,role
R3733	T6249	T6247	dobj	role,have
R3734	T6344	T6345	amod	cytoskeletal,protein
R3735	T6250	T6247	prep	in,have
R3736	T6345	T6346	compound	protein,interactions
R3737	T6346	T6343	pobj	interactions,of
R3738	T6347	T6348	punct	[,50
R3739	T6348	T6330	parataxis	50,shown
R3740	T6349	T6348	punct	],50
R3741	T6350	T6330	punct	.,shown
R3742	T6251	T6250	pcomp	organizing,in
R3743	T6352	T6353	nsubj	Ca2+,induces
R3744	T6252	T6253	det	the,cytoskeleton
R3745	T6354	T6353	advmod	also,induces
R3746	T6355	T6356	det	a,redistribution
R3747	T6356	T6353	dobj	redistribution,induces
R3748	T6253	T6251	dobj	cytoskeleton,organizing
R3749	T6357	T6356	compound	transbilayer,redistribution
R3750	T6358	T6356	compound	phospholipid,redistribution
R3751	T6254	T6253	compound	membrane,cytoskeleton
R3752	T6359	T6356	acl	inducing,redistribution
R3753	T6360	T6361	det	a,change
R3754	T6361	T6359	dobj	change,inducing
R3755	T6255	T6240	punct	", ",interact
R3756	T6362	T6361	compound	shape,change
R3757	T6363	T6361	prep	of,change
R3758	T6256	T6240	advcl	controlling,interact
R3759	T6364	T6365	amod	red,cells
R3760	T6365	T6363	pobj	cells,of
R3761	T6366	T6365	compound	blood,cells
R3762	T6257	T6258	compound	raft,protein
R3763	T6367	T6368	punct	[,51
R3764	T6368	T6353	parataxis	51,induces
R3765	T6369	T6368	punct	],51
R3766	T6258	T6259	compound	protein,associations
R3767	T6370	T6353	punct	.,induces
R3768	T6372	T6373	prep	In,drive
R3769	T6259	T6256	dobj	associations,controlling
R3770	T6374	T6372	pobj	addition,In
R3771	T6260	T6256	cc	or,controlling
R3772	T6375	T6373	punct	", ",drive
R3773	T6376	T6377	compound	Ca2+,ions
R3774	T6377	T6373	nsubj	ions,drive
R3775	T6261	T6256	conj	influencing,controlling
R3776	T6378	T6373	aux	can,drive
R3777	T6379	T6373	dobj	spiculation,drive
R3778	T6380	T6379	prep	of,spiculation
R3779	T6381	T6382	det	the,bilayer
R3780	T6262	T6263	det	the,strength
R3781	T6382	T6380	pobj	bilayer,of
R3782	T6383	T6382	compound	membrane,bilayer
R3783	T6263	T6261	dobj	strength,influencing
R3784	T6384	T6373	prep	without,drive
R3785	T6385	T6384	pcomp	involving,without
R3786	T6386	T6387	det	the,cytoskeleton
R3787	T6264	T6263	amod	ionic,strength
R3788	T6387	T6385	dobj	cytoskeleton,involving
R3789	T6388	T6389	punct	[,52
R3790	T6389	T6373	parataxis	52,drive
R3791	T6390	T6389	punct	],52
R3792	T6391	T6373	punct	.,drive
R3793	T6265	T6263	prep	of,strength
R3794	T6393	T6394	nsubj	We,observed
R3795	T6266	T6267	amod	red,cells
R3796	T6395	T6394	aux	have,observed
R3797	T6396	T6394	advmod	also,observed
R3798	T6397	T6398	det	a,defect
R3799	T6267	T6265	pobj	cells,of
R3800	T6268	T6267	compound	blood,cells
R3801	T6398	T6394	dobj	defect,observed
R3802	T6269	T6256	prep	on,controlling
R3803	T6399	T6398	prep	in,defect
R3804	T6270	T6271	poss	its,own
R3805	T6400	T6401	compound	platelet,function
R3806	T6401	T6399	pobj	function,in
R3807	T6402	T6394	prep	in,observed
R3808	T6403	T6404	det	the,mutant
R3809	T6271	T6269	pobj	own,on
R3810	T6404	T6402	pobj	mutant,in
R3811	T6405	T6406	compound	annexin,A7
R3812	T6406	T6404	compound	A7,mutant
R3813	T6272	T6269	cc	or,on
R3814	T6407	T6394	punct	.,observed
R3815	T6273	T6269	conj	by,on
R3816	T6409	T6410	prep	In,was
R3817	T6411	T6412	det	the,experiments
R3818	T6274	T6273	pcomp	interfering,by
R3819	T6412	T6409	pobj	experiments,In
R3820	T6413	T6414	compound	platelet,aggregation
R3821	T6414	T6412	compound	aggregation,experiments
R3822	T6275	T6274	prep	with,interfering
R3823	T6415	T6416	det	the,velocity
R3824	T6416	T6410	nsubj	velocity,was
R3825	T6417	T6416	amod	initial,velocity
R3826	T6276	T6277	amod	other,pathways
R3827	T6418	T6416	compound	aggregation,velocity
R3828	T6419	T6420	advmod	slightly,lower
R3829	T6277	T6275	pobj	pathways,with
R3830	T6420	T6410	acomp	lower,was
R3831	T6421	T6419	punct	", ",slightly
R3832	T6422	T6419	cc	but,slightly
R3833	T6423	T6419	conj	significantly,slightly
R3834	T6278	T6277	compound	signaling,pathways
R3835	T6424	T6410	prep	in,was
R3836	T6425	T6424	pobj	platelets,in
R3837	T6279	T6240	punct	.,interact
R3838	T6426	T6425	acl	lacking,platelets
R3839	T6427	T6428	compound	annexin,A7
R3840	T6428	T6426	dobj	A7,lacking
R3841	T6281	T6282	mark	As,discussed
R3842	T6429	T6410	punct	.,was
R3843	T6431	T6432	det	These,data
R3844	T6432	T6433	nsubjpass	data,reflected
R3845	T6434	T6433	auxpass	are,reflected
R3846	T6435	T6433	neg	not,reflected
R3847	T6282	T6283	advcl	discussed,involved
R3848	T6436	T6433	agent	by,reflected
R3849	T6437	T6438	det	a,change
R3850	T6438	T6436	pobj	change,by
R3851	T6284	T6282	advmod	above,discussed
R3852	T6439	T6438	prep	in,change
R3853	T6440	T6441	det	the,time
R3854	T6441	T6439	pobj	time,in
R3855	T6442	T6443	advmod	in,vivo
R3856	T6285	T6286	compound	annexin,A7
R3857	T6443	T6441	amod	vivo,time
R3858	T6444	T6441	compound	bleeding,time
R3859	T6445	T6433	punct	.,reflected
R3860	T6286	T6283	nsubjpass	A7,involved
R3861	T6447	T6448	advmod	However,is
R3862	T6449	T6450	det	the,speed
R3863	T6287	T6283	aux	could,involved
R3864	T6288	T6283	auxpass	be,involved
R3865	T6289	T6283	prep	in,involved
R3866	T6290	T6291	det	the,homeostasis
R3867	T6291	T6289	pobj	homeostasis,in
R3868	T6292	T6293	amod	cytoplasmic,Ca2+
R3869	T6450	T6448	nsubj	speed,is
R3870	T6293	T6291	compound	Ca2+,homeostasis
R3871	T6451	T6450	compound	reaction,speed
R3872	T6452	T6450	prep	of,speed
R3873	T6294	T6283	punct	.,involved
R3874	T6453	T6454	amod	murine,platelets
R3875	T6454	T6452	pobj	platelets,of
R3876	T6296	T6297	nsubjpass	It,demonstrated
R3877	T6455	T6456	advmod	much,higher
R3878	T6456	T6448	acomp	higher,is
R3879	T6457	T6456	prep	than,higher
R3880	T6458	T6457	pobj	those,than
R3881	T6298	T6297	aux	has,demonstrated
R3882	T6459	T6458	prep	of,those
R3883	T6460	T6459	pobj	human,of
R3884	T6461	T6448	cc	and,is
R3885	T6462	T6463	prep	due,missed
R3886	T6299	T6297	auxpass	been,demonstrated
R3887	T6463	T6448	conj	missed,is
R3888	T6464	T6462	pcomp	to,due
R3889	T6300	T6301	mark	that,exert
R3890	T6465	T6466	det	the,setup
R3891	T6466	T6462	pobj	setup,due
R3892	T6467	T6466	amod	technical,setup
R3893	T6301	T6297	ccomp	exert,demonstrated
R3894	T6468	T6463	nsubj	we,missed
R3895	T6469	T6463	aux	might,missed
R3896	T6470	T6463	aux	have,missed
R3897	T6471	T6472	amod	larger,changes
R3898	T6472	T6463	dobj	changes,missed
R3899	T6473	T6463	prep	in,missed
R3900	T6302	T6303	amod	micromolar,changes
R3901	T6474	T6475	det	the,samples
R3902	T6475	T6473	pobj	samples,in
R3903	T6476	T6475	compound	mouse,samples
R3904	T6303	T6301	nsubj	changes,exert
R3905	T6477	T6463	punct	.,missed
R3906	T6304	T6303	prep	of,changes
R3907	T6479	T6480	det	The,reaction
R3908	T6480	T6482	nsubjpass	reaction,caused
R3909	T6481	T6480	amod	immediate,reaction
R3910	T6305	T6306	det	the,concentration
R3911	T6483	T6480	prep	of,reaction
R3912	T6306	T6304	pobj	concentration,of
R3913	T6484	T6485	compound	mouse,platelets
R3914	T6485	T6483	pobj	platelets,of
R3915	T6307	T6306	amod	intracellular,concentration
R3916	T6486	T6480	cc	and,reaction
R3917	T6308	T6306	compound	Ca2+,concentration
R3919	T6309	T6310	det	a,effect
R3920	T6488	T6480	conj	absence,reaction
R3921	T6489	T6488	prep	of,absence
R3922	T6310	T6301	dobj	effect,exert
R3923	T6490	T6491	det	a,phase
R3924	T6491	T6489	pobj	phase,of
R3925	T6492	T6491	compound	lag,phase
R3926	T6493	T6491	prep	after,phase
R3927	T6311	T6310	amod	profound,effect
R3928	T6494	T6493	pobj	triggering,after
R3929	T6495	T6482	aux	may,caused
R3930	T6312	T6310	prep	on,effect
R3931	T6496	T6482	auxpass	be,caused
R3932	T6497	T6482	agent	by,caused
R3933	T6313	T6314	det	the,properties
R3934	T6498	T6499	det	an,generation
R3935	T6499	T6497	pobj	generation,by
R3936	T6500	T6501	advmod	immediately,initiated
R3937	T6314	T6312	pobj	properties,on
R3938	T6501	T6499	amod	initiated,generation
R3939	T6502	T6499	compound	thrombin,generation
R3940	T6315	T6314	compound	membrane,properties
R3941	T6503	T6504	punct	[,22
R3942	T6504	T6482	parataxis	22,caused
R3943	T6505	T6504	punct	],22
R3944	T6316	T6317	dep	that,regulate
R3945	T6506	T6482	punct	.,caused
R3946	T6508	T6509	mark	As,known
R3947	T6509	T6510	advcl	known,are
R3948	T6511	T6509	prep	from,known
R3949	T6317	T6314	relcl	regulate,properties
R3950	T6512	T6513	det	the,syndrome
R3951	T6513	T6511	pobj	syndrome,from
R3952	T6514	T6513	amod	frequent,syndrome
R3953	T6318	T6319	amod	red,cell
R3954	T6515	T6513	amod	human,syndrome
R3955	T6516	T6513	compound	vWF,syndrome
R3956	T6517	T6513	punct	-,syndrome
R3957	T6319	T6321	compound	cell,deformability
R3958	T6518	T6513	cc	or,syndrome
R3959	T6519	T6520	amod	other,diseases
R3960	T6320	T6319	compound	blood,cell
R3961	T6520	T6513	conj	diseases,syndrome
R3962	T6521	T6520	amod	haemostatic,diseases
R3963	T6522	T6510	punct	", ",are
R3964	T6321	T6317	dobj	deformability,regulate
R3965	T6523	T6524	amod	small,defects
R3966	T6524	T6510	nsubj	defects,are
R3967	T6322	T6323	punct	[,49
R3968	T6525	T6510	advmod	often,are
R3969	T6526	T6527	advmod	clinically,silent
R3970	T6527	T6510	acomp	silent,are
R3971	T6323	T6297	parataxis	49,demonstrated
R3972	T6528	T6510	cc	and,are
R3973	T6529	T6530	aux	do,result
R3974	T6324	T6323	nummod	48,49
R3975	T6530	T6510	conj	result,are
R3976	T6531	T6530	neg	not,result
R3977	T6532	T6530	prep	in,result
R3978	T6533	T6534	amod	physiological,changes
R3979	T6325	T6323	punct	",",49
R3980	T6534	T6532	pobj	changes,in
R3981	T6535	T6510	prep	under,are
R3982	T6326	T6323	punct	],49
R3983	T6536	T6537	amod	normal,conditions
R3984	T6537	T6535	pobj	conditions,under
R3985	T6538	T6510	punct	.,are
R3986	T6327	T6297	punct	.,demonstrated
R3987	T6540	T6541	advmod	Only,in
R3988	T6541	T6542	prep	in,become
R3989	T6329	T6330	advmod	Furthermore,shown
R3990	T6543	T6541	pobj	situations,in
R3991	T6544	T6543	prep	with,situations
R3992	T6545	T6546	amod	severe,injury
R3993	T6331	T6330	punct	", ",shown
R3994	T6546	T6544	pobj	injury,with
R3995	T6547	T6546	amod	physical,injury
R3996	T6548	T6542	punct	", ",become
R3997	T6549	T6550	amod	distinct,influences
R3998	T6550	T6542	nsubj	influences,become
R3999	T6551	T6550	amod	environmental,influences
R4000	T6552	T6550	cc	or,influences
R4001	T6332	T6333	det	the,Ca2+
R4002	T6553	T6554	amod	additional,platelet
R4003	T6554	T6550	conj	platelet,influences
R4004	T6555	T6554	nmod	attributes,platelet
R4005	T6333	T6330	nsubjpass	Ca2+,shown
R4006	T6334	T6333	amod	intracellular,Ca2+
R4007	T6335	T6330	auxpass	was,shown
R4008	T6556	T6554	prep	like,platelet
R4009	T6557	T6558	det	the,differences
R4010	T6336	T6337	aux	to,regulate
R4011	T6558	T6556	pobj	differences,like
R4012	T6559	T6560	nmod	platelet,antigen
R4013	T6337	T6330	xcomp	regulate,shown
R4014	T6560	T6558	nmod	antigen,differences
R4015	T6561	T6558	nmod	polymorphism,differences
R4016	T6562	T6563	punct	[,53
R4017	T6338	T6339	det	the,stability
R4018	T6563	T6558	parataxis	53,differences
R4019	T6564	T6563	punct	],53
R4020	T6565	T6542	aux	might,become
R4021	T6339	T6337	dobj	stability,regulate
R4022	T6566	T6542	acomp	apparent,become
R4023	T6567	T6542	punct	.,become
R4024	T6340	T6339	compound	membrane,stability
R4025	T6341	T6337	prep	through,regulate
R4026	T6342	T6341	pobj	modulation,through
R4027	T6343	T6342	prep	of,modulation
R4028	T6643	T6644	prep	In,report
R4029	T6645	T6646	det	this,paper
R4030	T6646	T6643	pobj	paper,In
R4031	T6647	T6644	nsubj	we,report
R4032	T6648	T6649	det	the,presence
R4033	T6649	T6644	dobj	presence,report
R4034	T6650	T6649	prep	of,presence
R4035	T6651	T6652	preconj	both,isoforms
R4036	T6652	T6650	pobj	isoforms,of
R4037	T6653	T6654	compound	annexin,A7
R4038	T6654	T6652	compound	A7,isoforms
R4039	T6655	T6649	prep	in,presence
R4040	T6656	T6657	amod	red,cells
R4041	T6657	T6655	pobj	cells,in
R4042	T6658	T6657	compound	blood,cells
R4043	T6659	T6660	advmod	where,are
R4044	T6660	T6657	relcl	are,cells
R4045	T6661	T6660	nsubj	they,are
R4046	T6662	T6660	acomp	abundant,are
R4047	T6663	T6660	prep	in,are
R4048	T6664	T6663	pobj	nanovesicles,in
R4049	T6665	T6666	dep	that,form
R4050	T6666	T6664	relcl	form,nanovesicles
R4051	T6667	T6666	prep	upon,form
R4052	T6668	T6669	compound	Ca2+,addition
R4053	T6669	T6667	pobj	addition,upon
R4054	T6670	T6644	punct	.,report
R4055	T6672	T6673	det	The,proteins
R4056	T6673	T6674	nsubjpass	proteins,required
R4057	T6675	T6674	auxpass	are,required
R4058	T6676	T6674	advmod	however,required
R4059	T6677	T6674	neg	not,required
R4060	T6678	T6674	prep	for,required
R4061	T6679	T6680	det	the,process
R4062	T6680	T6678	pobj	process,for
R4063	T6681	T6680	compound	vesiculation,process
R4064	T6682	T6674	punct	.,required
R4065	T6684	T6685	nsubj	They,are
R4066	T6686	T6685	advmod	also,are
R4067	T6687	T6685	neg	not,are
R4068	T6688	T6685	acomp	essential,are
R4069	T6689	T6688	prep	for,essential
R4070	T6690	T6691	det	the,formation
R4071	T6691	T6689	pobj	formation,for
R4072	T6692	T6691	prep	of,formation
R4073	T6693	T6694	amod	specific,domains
R4074	T6694	T6692	pobj	domains,of
R4075	T6695	T6694	compound	membrane,domains
R4076	T6696	T6697	amod	such,as
R4077	T6697	T6694	prep	as,domains
R4078	T6698	T6699	compound	lipid,rafts
R4079	T6699	T6697	pobj	rafts,as
R4080	T6700	T6685	punct	", ",are
R4081	T6701	T6685	prep	as,are
R4082	T6702	T6703	advmod	exogenously,added
R4083	T6703	T6704	amod	added,A7
R4084	T6704	T6701	pobj	A7,as
R4085	T6705	T6704	amod	recombinant,A7
R4086	T6706	T6704	compound	annexin,A7
R4087	T6707	T6704	acl	redistributed,A7
R4088	T6708	T6707	prep	to,redistributed
R4089	T6709	T6710	amod	similar,positions
R4090	T6710	T6708	pobj	positions,to
R4091	T6711	T6704	prep	in,A7
R4092	T6712	T6713	det	a,gradient
R4093	T6713	T6711	pobj	gradient,in
R4094	T6714	T6713	compound	density,gradient
R4095	T6715	T6713	acl	containing,gradient
R4096	T6716	T6715	dobj	membranes,containing
R4097	T6717	T6716	acl	derived,membranes
R4098	T6718	T6717	prep	from,derived
R4099	T6719	T6720	amod	red,cells
R4100	T6720	T6718	pobj	cells,from
R4101	T6721	T6720	compound	blood,cells
R4102	T6722	T6720	prep	of,cells
R4103	T6723	T6724	nmod	anxA7,mice
R4104	T6724	T6722	pobj	mice,of
R4105	T6725	T6723	punct	-,anxA7
R4106	T6726	T6723	punct	/,anxA7
R4107	T6727	T6723	punct	-,anxA7
R4108	T6728	T6685	punct	.,are
R4109	T6730	T6731	det	The,change
R4110	T6731	T6735	nsubj	change,be
R4111	T6732	T6731	amod	observed,change
R4112	T6733	T6734	compound	cell,shape
R4113	T6734	T6731	compound	shape,change
R4114	T6736	T6731	prep	of,change
R4115	T6737	T6736	pobj	erythrocytes,of
R4116	T6738	T6737	acl	lacking,erythrocytes
R4117	T6739	T6740	compound	annexin,A7
R4118	T6740	T6738	dobj	A7,lacking
R4119	T6741	T6735	aux	might,be
R4120	T6742	T6735	prep	due,be
R4121	T6743	T6742	pcomp	to,due
R4122	T6744	T6742	pobj	alterations,due
R4123	T6745	T6744	prep	in,alterations
R4124	T6746	T6747	det	the,cytoskeleton
R4125	T6747	T6745	pobj	cytoskeleton,in
R4126	T6748	T6747	compound	erythrocyte,cytoskeleton
R4127	T6749	T6735	punct	.,be
R4128	T6751	T6752	mark	As,ruled
R4129	T6752	T6761	advcl	ruled,mediated
R4130	T6753	T6754	det	a,interaction
R4131	T6754	T6752	nsubjpass	interaction,ruled
R4132	T6755	T6754	amod	direct,interaction
R4133	T6756	T6754	prep	with,interaction
R4134	T6757	T6758	compound	F,actin
R4135	T6758	T6756	pobj	actin,with
R4136	T6759	T6758	punct	-,actin
R4137	T6760	T6752	auxpass	was,ruled
R4138	T6762	T6752	prt	out,ruled
R4139	T6763	T6761	punct	", ",mediated
R4140	T6764	T6765	det	this,effect
R4141	T6765	T6761	nsubjpass	effect,mediated
R4142	T6766	T6761	aux	might,mediated
R4143	T6767	T6761	auxpass	be,mediated
R4144	T6768	T6761	agent	by,mediated
R4145	T6769	T6770	poss	annexin,activity
R4146	T6770	T6768	pobj	activity,by
R4147	T6771	T6769	case	's,annexin
R4148	T6772	T6773	npadvmod	Ca2+,binding
R4149	T6773	T6770	amod	binding,activity
R4150	T6774	T6773	punct	-,binding
R4151	T6775	T6761	punct	.,mediated
R4152	T6880	T6879	prep	of,Acquisition
R4153	T6881	T6882	nmod	murine,blood
R4154	T6882	T6885	compound	blood,samples
R4155	T6883	T6881	cc	and,murine
R4156	T6884	T6881	conj	human,murine
R4157	T6885	T6880	pobj	samples,of
R4158	T6887	T6888	nsubjpass	Blood,collected
R4159	T6889	T6887	prep	from,Blood
R4160	T6890	T6891	nmod	129Sv,mice
R4161	T6891	T6889	pobj	mice,from
R4162	T6892	T6893	amod	wild,type
R4163	T6893	T6891	nmod	type,mice
R4164	T6894	T6893	cc	and,type
R4165	T6895	T6896	compound	annexin,A7
R4166	T6896	T6893	conj	A7,type
R4167	T6897	T6898	compound	knock,out
R4168	T6898	T6891	compound	out,mice
R4169	T6899	T6900	punct	(,anxA7
R4170	T6900	T6891	parataxis	anxA7,mice
R4171	T6901	T6900	punct	-,anxA7
R4172	T6902	T6900	punct	/,anxA7
R4173	T6903	T6900	punct	-,anxA7
R4174	T6904	T6900	punct	),anxA7
R4175	T6905	T6887	acl	kept,Blood
R4176	T6906	T6905	prep	under,kept
R4177	T6907	T6908	npadvmod	pathogen,free
R4178	T6908	T6910	amod	free,conditions
R4179	T6909	T6908	punct	-,free
R4180	T6910	T6906	pobj	conditions,under
R4181	T6911	T6905	cc	and,kept
R4182	T6912	T6905	conj	fed,kept
R4183	T6913	T6912	prep	with,fed
R4184	T6914	T6915	amod	regular,food
R4185	T6915	T6913	pobj	food,with
R4186	T6916	T6888	punct	", ",collected
R4187	T6917	T6888	auxpass	was,collected
R4188	T6918	T6888	prep	in,collected
R4189	T6919	T6920	nummod	1,ml
R4190	T6920	T6921	compound	ml,syringes
R4191	T6921	T6918	pobj	syringes,in
R4192	T6922	T6888	prep	with,collected
R4193	T6923	T6924	det	a,needle
R4194	T6924	T6927	nsubj	needle,punctating
R4195	T6925	T6926	nummod	22,gauge
R4196	T6926	T6924	compound	gauge,needle
R4197	T6927	T6922	pcomp	punctating,with
R4198	T6928	T6929	det	the,ventricle
R4199	T6929	T6927	dobj	ventricle,punctating
R4200	T6930	T6929	amod	right,ventricle
R4201	T6931	T6929	amod	cardiac,ventricle
R4202	T6932	T6933	advmod	immediately,killed
R4203	T6933	T6927	advcl	killed,punctating
R4204	T6934	T6933	mark	after,killed
R4205	T6935	T6933	nsubjpass	they,killed
R4206	T6936	T6933	aux	had,killed
R4207	T6937	T6933	auxpass	been,killed
R4208	T6938	T6933	prep	by,killed
R4209	T6939	T6940	amod	cervical,dislocation
R4210	T6940	T6938	pobj	dislocation,by
R4211	T6941	T6888	punct	.,collected
R4212	T6943	T6944	nsubjpass	Coagulation,inhibited
R4213	T6945	T6944	advmod	generally,inhibited
R4214	T6946	T6944	auxpass	was,inhibited
R4215	T6947	T6944	prep	with,inhibited
R4216	T6948	T6949	quantmod	1,10
R4217	T6949	T6951	nummod	10,volume
R4218	T6950	T6949	punct	/,10
R4219	T6951	T6947	pobj	volume,with
R4220	T6952	T6951	prep	of,volume
R4221	T6953	T6954	nummod	10,mM
R4222	T6954	T6955	compound	mM,NaEDTA
R4223	T6955	T6952	pobj	NaEDTA,of
R4224	T6956	T6955	punct	", ",NaEDTA
R4225	T6957	T6955	npadvmod	pH,NaEDTA
R4226	T6958	T6957	nummod	7.5,pH
R4227	T6959	T6951	punct	", ",volume
R4228	T6960	T6961	advmod	already,present
R4229	T6961	T6951	relcl	present,volume
R4230	T6962	T6961	prep	in,present
R4231	T6963	T6964	det	the,syringe
R4232	T6964	T6962	pobj	syringe,in
R4233	T6965	T6944	punct	.,inhibited
R4234	T6967	T6968	det	The,mice
R4235	T6968	T6969	nsubjpass	mice,killed
R4236	T6970	T6969	auxpass	were,killed
R4237	T6971	T6969	prep	by,killed
R4238	T6972	T6973	amod	cervical,dislocation
R4239	T6973	T6971	pobj	dislocation,by
R4240	T6974	T6969	prep	in,killed
R4241	T6975	T6974	pobj	order,in
R4242	T6976	T6977	aux	to,avoid
R4243	T6977	T6975	acl	avoid,order
R4244	T6978	T6979	det	any,effect
R4245	T6979	T6977	dobj	effect,avoid
R4246	T6980	T6979	prep	of,effect
R4247	T6981	T6982	amod	anaesthetic,chemicals
R4248	T6982	T6980	pobj	chemicals,of
R4249	T6983	T6979	prep	on,effect
R4250	T6984	T6985	compound	blood,parameters
R4251	T6985	T6983	pobj	parameters,on
R4252	T6986	T6969	punct	.,killed
R4253	T6988	T6989	det	The,mice
R4254	T6989	T6994	nsubjpass	mice,matched
R4255	T6990	T6991	amod	wild,type
R4256	T6991	T6989	nmod	type,mice
R4257	T6992	T6991	cc	and,type
R4258	T6993	T6991	conj	mutant,type
R4259	T6995	T6994	auxpass	were,matched
R4260	T6996	T6994	prep	regarding,matched
R4261	T6997	T6998	poss	their,age
R4262	T6998	T6996	pobj	age,regarding
R4263	T6999	T6998	punct	", ",age
R4264	T7000	T6998	conj	weight,age
R4265	T7001	T7000	cc	and,weight
R4266	T7002	T7000	conj	sex,weight
R4267	T7003	T6994	punct	.,matched
R4268	T7005	T7006	det	The,daytime
R4269	T7006	T7007	nsubjpass	daytime,kept
R4270	T7008	T7006	prep	of,daytime
R4271	T7009	T7010	compound	blood,collection
R4272	T7010	T7008	pobj	collection,of
R4273	T7011	T7006	punct	", ",daytime
R4274	T7012	T7013	amod	sampling,site
R4275	T7013	T7006	conj	site,daytime
R4276	T7014	T7013	cc	and,site
R4277	T7015	T7016	compound	collection,method
R4278	T7016	T7013	conj	method,site
R4279	T7017	T7007	auxpass	were,kept
R4280	T7018	T7007	oprd	constant,kept
R4281	T7019	T7007	prep	during,kept
R4282	T7020	T7021	det	all,experiments
R4283	T7021	T7019	pobj	experiments,during
R4284	T7022	T7007	punct	.,kept
R4285	T7024	T7025	det	A,volume
R4286	T7025	T7030	nsubj	volume,consisted
R4287	T7026	T7025	amod	typical,volume
R4288	T7027	T7028	amod	murine,sample
R4289	T7028	T7025	compound	sample,volume
R4290	T7029	T7028	compound	blood,sample
R4291	T7031	T7030	prep	of,consisted
R4292	T7032	T7033	nummod	550,μl
R4293	T7033	T7031	pobj	μl,of
R4294	T7034	T7030	punct	", ",consisted
R4295	T7035	T7030	prep	with,consisted
R4296	T7036	T7035	pobj	variations,with
R4297	T7037	T7036	acl	ranging,variations
R4298	T7038	T7037	prep	from,ranging
R4299	T7039	T7040	nummod	200,μl
R4300	T7040	T7038	pobj	μl,from
R4301	T7041	T7038	prep	to,from
R4302	T7042	T7043	nummod	900,μl
R4303	T7043	T7041	pobj	μl,to
R4304	T7044	T7030	punct	.,consisted
R4305	T7046	T7047	amod	Human,samples
R4306	T7047	T7049	nsubjpass	samples,collected
R4307	T7048	T7047	compound	blood,samples
R4308	T7050	T7047	prep	from,samples
R4309	T7051	T7052	det	the,authors
R4310	T7052	T7050	pobj	authors,from
R4311	T7053	T7049	auxpass	were,collected
R4312	T7054	T7049	prep	by,collected
R4313	T7055	T7056	compound	vein,puncture
R4314	T7056	T7054	pobj	puncture,by
R4315	T7057	T7049	advcl	using,collected
R4316	T7058	T7059	amod	common,monovettes
R4317	T7059	T7057	dobj	monovettes,using
R4318	T7060	T7059	compound	EDTA,monovettes
R4319	T7061	T7059	punct	-,monovettes
R4320	T7062	T7063	punct	(,Sarstedt
R4321	T7063	T7049	parataxis	Sarstedt,collected
R4322	T7064	T7063	punct	),Sarstedt
R4323	T7065	T7049	punct	.,collected
R4324	T7067	T7068	nsubj	We,performed
R4325	T7069	T7070	poss	our,studies
R4326	T7070	T7068	dobj	studies,performed
R4327	T7071	T7068	advcl	using,performed
R4328	T7072	T7073	advmod	well,standardized
R4329	T7073	T7074	amod	standardized,conditions
R4330	T7074	T7071	dobj	conditions,using
R4331	T7075	T7074	compound	sampling,conditions
R4332	T7076	T7068	punct	", ",performed
R4333	T7077	T7078	mark	as,show
R4334	T7078	T7068	advcl	show,performed
R4335	T7079	T7078	nsubj	differences,show
R4336	T7080	T7079	prep	in,differences
R4337	T7081	T7082	det	the,site
R4338	T7082	T7080	pobj	site,in
R4339	T7083	T7084	compound	blood,sampling
R4340	T7084	T7082	compound	sampling,site
R4341	T7085	T7079	punct	", ",differences
R4342	T7086	T7087	prep	for,between
R4343	T7087	T7079	prep	between,differences
R4344	T7088	T7086	pobj	example,for
R4345	T7089	T7087	pobj	tail,between
R4346	T7090	T7089	cc	and,tail
R4347	T7091	T7089	conj	heart,tail
R4348	T7092	T7078	punct	", ",show
R4349	T7093	T7094	amod	large,changes
R4350	T7094	T7078	dobj	changes,show
R4351	T7095	T7094	prep	in,changes
R4352	T7096	T7097	det	all,counts
R4353	T7097	T7095	pobj	counts,in
R4354	T7098	T7099	compound	cell,type
R4355	T7099	T7097	compound	type,counts
R4356	T7100	T7068	punct	.,performed
R4357	T7102	T7103	amod	First,draw
R4358	T7103	T7107	nsubj	draw,affect
R4359	T7104	T7102	cc	and,First
R4360	T7105	T7102	conj	second,First
R4361	T7106	T7103	compound	sample,draw
R4362	T7108	T7109	compound	blood,measurements
R4363	T7109	T7107	dobj	measurements,affect
R4364	T7110	T7107	punct	", ",affect
R4365	T7111	T7107	advmod	too,affect
R4366	T7112	T7113	punct	[,22
R4367	T7113	T7107	parataxis	22,affect
R4368	T7114	T7113	punct	],22
R4369	T7115	T7107	punct	.,affect
R4370	T7117	T7118	advmod	Also,affects
R4371	T7119	T7120	det	the,background
R4372	T7120	T7118	nsubj	background,affects
R4373	T7121	T7120	amod	genetic,background
R4374	T7122	T7120	prep	in,background
R4375	T7123	T7124	amod	common,mice
R4376	T7124	T7122	pobj	mice,in
R4377	T7125	T7124	nmod	laboratory,mice
R4378	T7126	T7125	cc	and,laboratory
R4379	T7127	T7125	conj	transgenic,laboratory
R4380	T7128	T7129	det	the,phenotype
R4381	T7129	T7118	dobj	phenotype,affects
R4382	T7130	T7118	punct	.,affects
R4383	T7132	T7133	det	A,change
R4384	T7133	T7134	nsubj	change,protect
R4385	T7135	T7133	prep	from,change
R4386	T7136	T7137	nummod	one,strain
R4387	T7137	T7135	pobj	strain,from
R4388	T7138	T7133	prep	to,change
R4389	T7139	T7138	pobj	another,to
R4390	T7140	T7134	aux	may,protect
R4391	T7141	T7134	dobj	mice,protect
R4392	T7142	T7134	prep	from,protect
R4393	T7143	T7142	pobj	effects,from
R4394	T7144	T7143	prep	of,effects
R4395	T7145	T7146	det	the,defect
R4396	T7146	T7144	pobj	defect,of
R4397	T7147	T7148	advmod	primarily,induced
R4398	T7148	T7146	amod	induced,defect
R4399	T7149	T7146	amod	genetic,defect
R4400	T7150	T7134	punct	.,protect
R4401	T7152	T7153	prep	For,have
R4402	T7154	T7152	pobj	example,For
R4403	T7155	T7153	punct	", ",have
R4404	T7156	T7157	compound	BALB,c
R4405	T7157	T7159	compound	c,mice
R4406	T7158	T7157	punct	/,c
R4407	T7159	T7153	nsubj	mice,have
R4408	T7160	T7161	det	a,velocity
R4409	T7161	T7153	dobj	velocity,have
R4410	T7162	T7163	advmod	significantly,increased
R4411	T7163	T7161	amod	increased,velocity
R4412	T7164	T7161	prep	of,velocity
R4413	T7165	T7166	compound	platelet,aggregation
R4414	T7166	T7164	pobj	aggregation,of
R4415	T7167	T7153	prep	as,have
R4416	T7168	T7167	prep	compared,as
R4417	T7169	T7168	prep	to,compared
R4418	T7170	T7171	compound	129Sv,mice
R4419	T7171	T7169	pobj	mice,to
R4420	T7172	T7171	punct	", ",mice
R4421	T7173	T7174	dep	which,used
R4422	T7174	T7171	relcl	used,mice
R4423	T7175	T7174	auxpass	were,used
R4424	T7176	T7174	prep	throughout,used
R4425	T7177	T7178	det	this,study
R4426	T7178	T7176	pobj	study,throughout
R4427	T7179	T7180	punct	[,23
R4428	T7180	T7153	parataxis	23,have
R4429	T7181	T7180	punct	],23
R4430	T7182	T7153	punct	.,have
R4431	T7273	T7274	npadvmod	Self,forming
R4432	T7274	T7275	amod	forming,gradients
R4433	T7276	T7275	compound	iodixanol,gradients
R4434	T7277	T7275	compound	density,gradients
R4435	T7278	T7275	prep	of,gradients
R4436	T7279	T7280	amod	human,cells
R4437	T7280	T7278	pobj	cells,of
R4438	T7281	T7280	amod	red,cells
R4439	T7282	T7280	compound	blood,cells
R4440	T7284	T7285	det	The,distribution
R4441	T7285	T7287	nsubjpass	distribution,addressed
R4442	T7286	T7285	amod	subcellular,distribution
R4443	T7288	T7285	prep	of,distribution
R4444	T7289	T7290	compound	annexin,A7
R4445	T7290	T7288	pobj	A7,of
R4446	T7291	T7287	auxpass	was,addressed
R4447	T7292	T7287	prep	according,addressed
R4448	T7293	T7292	prep	to,according
R4449	T7294	T7293	punct	[,to
R4450	T7295	T7293	pobj	24,to
R4451	T7296	T7287	punct	],addressed
R4452	T7297	T7287	punct	.,addressed
R4453	T7299	T7300	amod	Red,cells
R4454	T7300	T7302	nsubjpass	cells,centrifuged
R4455	T7301	T7300	compound	blood,cells
R4456	T7303	T7302	auxpass	were,centrifuged
R4457	T7304	T7302	cc	and,centrifuged
R4458	T7305	T7302	conj	washed,centrifuged
R4459	T7306	T7305	prep	in,washed
R4460	T7307	T7308	amod	isotonic,solution
R4461	T7308	T7306	pobj	solution,in
R4462	T7309	T7310	amod	buffered,salt
R4463	T7310	T7308	compound	salt,solution
R4464	T7311	T7305	punct	", ",washed
R4465	T7312	T7305	conj	collected,washed
R4466	T7313	T7312	prep	in,collected
R4467	T7314	T7315	npadvmod	ice,cold
R4468	T7315	T7316	amod	cold,buffer
R4469	T7316	T7313	pobj	buffer,in
R4470	T7317	T7316	compound	lysis,buffer
R4471	T7318	T7319	punct	(,Hepes
R4472	T7319	T7316	parataxis	Hepes,buffer
R4473	T7320	T7321	nummod	20,mM
R4474	T7321	T7319	compound	mM,Hepes
R4475	T7322	T7319	punct	", ",Hepes
R4476	T7323	T7319	npadvmod	pH,Hepes
R4477	T7324	T7323	nummod	7.4,pH
R4478	T7325	T7319	punct	", ",Hepes
R4479	T7326	T7327	nummod	200,μM
R4480	T7327	T7328	compound	μM,CaCl2
R4481	T7328	T7319	conj	CaCl2,Hepes
R4482	T7329	T7328	punct	", ",CaCl2
R4483	T7330	T7331	nummod	0.25,M
R4484	T7331	T7332	compound	M,sucrose
R4485	T7332	T7328	conj	sucrose,CaCl2
R4486	T7333	T7332	punct	", ",sucrose
R4487	T7334	T7332	cc	and,sucrose
R4488	T7335	T7336	compound	proteinase,inhibitors
R4489	T7336	T7332	conj	inhibitors,sucrose
R4490	T7337	T7338	punct	(,Roche
R4491	T7338	T7336	parataxis	Roche,inhibitors
R4492	T7339	T7338	punct	),Roche
R4493	T7340	T7336	punct	),inhibitors
R4494	T7341	T7312	punct	", ",collected
R4495	T7342	T7312	conj	homogenized,collected
R4496	T7343	T7342	prep	by,homogenized
R4497	T7344	T7345	det	a,homogenizer
R4498	T7345	T7343	pobj	homogenizer,by
R4499	T7346	T7347	advmod	loosely,fitting
R4500	T7347	T7345	amod	fitting,homogenizer
R4501	T7348	T7345	compound	dounce,homogenizer
R4502	T7349	T7345	cc	and,homogenizer
R4503	T7350	T7351	amod	additional,passages
R4504	T7351	T7345	conj	passages,homogenizer
R4505	T7352	T7351	prep	through,passages
R4506	T7353	T7354	det	a,needle
R4507	T7354	T7352	pobj	needle,through
R4508	T7355	T7356	nummod	22,gauge
R4509	T7356	T7354	compound	gauge,needle
R4510	T7357	T7302	punct	.,centrifuged
R4511	T7359	T7360	det	A,solution
R4512	T7360	T7364	nsubjpass	solution,established
R4513	T7361	T7362	nummod	50,%
R4514	T7362	T7360	compound	%,solution
R4515	T7363	T7360	compound	iodixanol,solution
R4516	T7365	T7364	auxpass	was,established
R4517	T7366	T7364	prep	by,established
R4518	T7367	T7366	pcomp	mixing,by
R4519	T7368	T7369	compound	Optiprep,solution
R4520	T7369	T7367	dobj	solution,mixing
R4521	T7370	T7371	punct	(,Sigma
R4522	T7371	T7369	parataxis	Sigma,solution
R4523	T7372	T7373	nummod	60,%
R4524	T7373	T7374	compound	%,iodixanol
R4525	T7374	T7371	dep	iodixanol,Sigma
R4526	T7375	T7371	punct	;,Sigma
R4527	T7376	T7371	punct	),Sigma
R4528	T7377	T7367	prep	with,mixing
R4529	T7378	T7377	pobj	buffer,with
R4530	T7379	T7380	punct	(,sucrose
R4531	T7380	T7378	parataxis	sucrose,buffer
R4532	T7381	T7382	nummod	120,mM
R4533	T7382	T7383	compound	mM,Hepes
R4534	T7383	T7380	dep	Hepes,sucrose
R4535	T7384	T7383	punct	", ",Hepes
R4536	T7385	T7383	npadvmod	pH,Hepes
R4537	T7386	T7385	nummod	7.4,pH
R4538	T7387	T7380	punct	", ",sucrose
R4539	T7388	T7389	nummod	1.2,mM
R4540	T7389	T7390	compound	mM,CaCl2
R4541	T7390	T7380	dep	CaCl2,sucrose
R4542	T7391	T7380	punct	", ",sucrose
R4543	T7392	T7393	nummod	0.25,M
R4544	T7393	T7380	compound	M,sucrose
R4545	T7394	T7380	punct	),sucrose
R4546	T7395	T7364	punct	.,established
R4547	T7397	T7398	nummod	Seven,parts
R4548	T7398	T7399	nsubjpass	parts,mixed
R4549	T7400	T7398	prep	of,parts
R4550	T7401	T7402	det	this,solution
R4551	T7402	T7400	pobj	solution,of
R4552	T7403	T7404	nummod	50,%
R4553	T7404	T7402	compound	%,solution
R4554	T7405	T7402	compound	iodixanol,solution
R4555	T7406	T7399	auxpass	were,mixed
R4556	T7407	T7399	prep	with,mixed
R4557	T7408	T7409	nummod	thirteen,parts
R4558	T7409	T7407	pobj	parts,with
R4559	T7410	T7409	prep	of,parts
R4560	T7411	T7412	det	the,solution
R4561	T7412	T7410	pobj	solution,of
R4562	T7413	T7414	amod	red,cell
R4563	T7414	T7412	compound	cell,solution
R4564	T7415	T7414	compound	blood,cell
R4565	T7416	T7399	punct	", ",mixed
R4566	T7417	T7399	advcl	generating,mixed
R4567	T7418	T7419	det	a,solution
R4568	T7419	T7417	dobj	solution,generating
R4569	T7420	T7419	compound	gradient,solution
R4570	T7421	T7419	acl	containing,solution
R4571	T7422	T7423	nummod	17.5,%
R4572	T7423	T7424	compound	%,iodixanol
R4573	T7424	T7421	dobj	iodixanol,containing
R4574	T7425	T7399	punct	.,mixed
R4575	T7427	T7428	det	The,mixture
R4576	T7428	T7429	nsubj	mixture,filled
R4577	T7430	T7429	aux	was,filled
R4578	T7431	T7429	prep	into,filled
R4579	T7432	T7433	det	a,tube
R4580	T7433	T7431	pobj	tube,into
R4581	T7434	T7433	amod	centrifuge,tube
R4582	T7435	T7433	amod	underlayed,tube
R4583	T7436	T7435	prep	by,underlayed
R4584	T7437	T7436	pobj	cushions,by
R4585	T7438	T7437	prep	of,cushions
R4586	T7439	T7440	nummod	30,%
R4587	T7440	T7441	nmod	%,iodixanol
R4588	T7441	T7438	pobj	iodixanol,of
R4589	T7442	T7440	cc	and,%
R4590	T7443	T7444	nummod	35,%
R4591	T7444	T7440	conj	%,%
R4592	T7445	T7429	cc	and,filled
R4593	T7446	T7429	conj	centrifuged,filled
R4594	T7447	T7446	prep	for,centrifuged
R4595	T7448	T7449	nummod	3,hours
R4596	T7449	T7447	pobj	hours,for
R4597	T7450	T7446	prep	at,centrifuged
R4598	T7451	T7452	nummod	"270,000",g
R4599	T7452	T7450	pobj	g,at
R4600	T7453	T7452	punct	×,g
R4601	T7454	T7446	prep	in,centrifuged
R4602	T7455	T7456	det	a,rotor
R4603	T7456	T7454	pobj	rotor,in
R4604	T7457	T7458	compound	SW41,Ti
R4605	T7458	T7456	compound	Ti,rotor
R4606	T7459	T7460	compound	swing,out
R4607	T7460	T7456	compound	out,rotor
R4608	T7461	T7462	punct	(,Beckman
R4609	T7462	T7456	parataxis	Beckman,rotor
R4610	T7463	T7462	punct	),Beckman
R4611	T7464	T7465	aux	to,achieve
R4612	T7465	T7429	advcl	achieve,filled
R4613	T7466	T7467	det	a,gradient
R4614	T7467	T7465	dobj	gradient,achieve
R4615	T7468	T7469	advmod	nearly,linear
R4616	T7469	T7467	amod	linear,gradient
R4617	T7470	T7467	compound	density,gradient
R4618	T7471	T7472	punct	(,g
R4619	T7472	T7467	parataxis	g,gradient
R4620	T7473	T7472	advmod	approximately,g
R4621	T7474	T7472	nummod	1.06,g
R4622	T7475	T7476	punct	/,ml
R4623	T7476	T7472	prep	ml,g
R4624	T7477	T7472	prep	to,g
R4625	T7478	T7479	nummod	1.20,g
R4626	T7479	T7477	pobj	g,to
R4627	T7480	T7481	punct	/,ml
R4628	T7481	T7479	prep	ml,g
R4629	T7482	T7472	punct	),g
R4630	T7483	T7484	punct	[,24
R4631	T7484	T7429	parataxis	24,filled
R4632	T7485	T7484	punct	],24
R4633	T7486	T7429	punct	.,filled
R4634	T7488	T7489	nsubjpass	Fractions,collected
R4635	T7490	T7488	prep	of,Fractions
R4636	T7491	T7492	nummod	0.6,ml
R4637	T7492	T7490	pobj	ml,of
R4638	T7493	T7489	auxpass	were,collected
R4639	T7494	T7489	prep	from,collected
R4640	T7495	T7496	det	the,top
R4641	T7496	T7494	pobj	top,from
R4642	T7497	T7496	prep	of,top
R4643	T7498	T7499	det	the,gradient
R4644	T7499	T7497	pobj	gradient,of
R4645	T7500	T7489	prep	by,collected
R4646	T7501	T7502	det	a,syringe
R4647	T7502	T7500	pobj	syringe,by
R4648	T7503	T7504	nummod	1,ml
R4649	T7504	T7502	compound	ml,syringe
R4650	T7505	T7489	prep	without,collected
R4651	T7506	T7505	pcomp	using,without
R4652	T7507	T7508	det	a,needle
R4653	T7508	T7506	dobj	needle,using
R4654	T7509	T7489	cc	and,collected
R4655	T7510	T7511	advmod	immediately,frozen
R4656	T7511	T7489	conj	frozen,collected
R4657	T7512	T7511	prep	in,frozen
R4658	T7513	T7514	amod	liquid,nitrogen
R4659	T7514	T7512	pobj	nitrogen,in
R4660	T7515	T7511	prep	for,frozen
R4661	T7516	T7517	amod	further,use
R4662	T7517	T7515	pobj	use,for
R4663	T7518	T7489	punct	.,collected
R4664	T7632	T7633	compound	Exovesicle,generation
R4665	T7634	T7633	prep	from,generation
R4666	T7635	T7636	amod	human,cells
R4667	T7636	T7634	pobj	cells,from
R4668	T7637	T7635	cc	and,human
R4669	T7638	T7635	conj	murine,human
R4670	T7639	T7636	amod	red,cells
R4671	T7640	T7636	compound	blood,cells
R4672	T7642	T7643	amod	Red,cells
R4673	T7643	T7645	nsubj	cells,form
R4674	T7644	T7643	compound	blood,cells
R4675	T7646	T7645	advmod	naturally,form
R4676	T7647	T7645	aux	can,form
R4677	T7648	T7649	npadvmod	hemoglobin,containing
R4678	T7649	T7650	amod	containing,exovesicles
R4679	T7650	T7645	dobj	exovesicles,form
R4680	T7651	T7645	punct	.,form
R4681	T7653	T7654	advmod	In,vitro
R4682	T7654	T7655	advmod	vitro,is
R4683	T7656	T7657	det	these,formation
R4684	T7657	T7655	nsubj	formation,is
R4685	T7658	T7657	compound	vesicle,formation
R4686	T7659	T7660	npadvmod	Ca2+,induced
R4687	T7660	T7655	acomp	induced,is
R4688	T7661	T7655	punct	.,is
R4689	T7663	T7664	advmod	Freshly,collected
R4690	T7664	T7665	amod	collected,samples
R4691	T7665	T7671	nsubjpass	samples,centrifuged
R4692	T7666	T7667	nmod	lithium,heparin
R4693	T7667	T7665	nmod	heparin,samples
R4694	T7668	T7667	punct	-,heparin
R4695	T7669	T7665	amod	anticoagulated,samples
R4696	T7670	T7665	compound	blood,samples
R4697	T7672	T7671	auxpass	were,centrifuged
R4698	T7673	T7671	prep	for,centrifuged
R4699	T7674	T7675	nummod	5,minutes
R4700	T7675	T7673	pobj	minutes,for
R4701	T7676	T7671	prep	at,centrifuged
R4702	T7677	T7678	nummod	400,g
R4703	T7678	T7676	pobj	g,at
R4704	T7679	T7678	punct	×,g
R4705	T7680	T7678	cc	and,g
R4706	T7681	T7682	nummod	4,°C
R4707	T7682	T7678	conj	°C,g
R4708	T7683	T7671	punct	.,centrifuged
R4709	T7685	T7686	det	The,erythrocytes
R4710	T7686	T7687	nsubjpass	erythrocytes,washed
R4711	T7688	T7687	auxpass	were,washed
R4712	T7689	T7690	nummod	five,times
R4713	T7690	T7687	npadvmod	times,washed
R4714	T7691	T7687	prep	with,washed
R4715	T7692	T7693	nummod	20,mM
R4716	T7693	T7694	compound	mM,Hepes
R4717	T7694	T7691	pobj	Hepes,with
R4718	T7695	T7694	punct	", ",Hepes
R4719	T7696	T7694	npadvmod	pH,Hepes
R4720	T7697	T7696	nummod	7.5,pH
R4721	T7698	T7694	punct	", ",Hepes
R4722	T7699	T7694	cc	and,Hepes
R4723	T7700	T7701	nummod	150,mM
R4724	T7701	T7702	compound	mM,NaCl
R4725	T7702	T7694	conj	NaCl,Hepes
R4726	T7703	T7704	punct	(,buffer
R4727	T7704	T7702	parataxis	buffer,NaCl
R4728	T7705	T7704	amod	washing,buffer
R4729	T7706	T7704	punct	),buffer
R4730	T7707	T7687	punct	.,washed
R4731	T7709	T7710	det	A,volume
R4732	T7710	T7711	nsubjpass	volume,combined
R4733	T7712	T7710	prep	of,volume
R4734	T7713	T7714	nummod	500,μl
R4735	T7714	T7715	nmod	μl,cells
R4736	T7715	T7712	pobj	cells,of
R4737	T7716	T7715	amod	washed,cells
R4738	T7717	T7715	amod	red,cells
R4739	T7718	T7715	compound	blood,cells
R4740	T7719	T7711	auxpass	were,combined
R4741	T7720	T7711	prep	with,combined
R4742	T7721	T7722	nummod	3,ml
R4743	T7722	T7720	pobj	ml,with
R4744	T7723	T7722	prep	of,ml
R4745	T7724	T7725	compound	vesiculation,buffer
R4746	T7725	T7723	pobj	buffer,of
R4747	T7726	T7727	punct	(,CaCl2
R4748	T7727	T7725	parataxis	CaCl2,buffer
R4749	T7728	T7729	nummod	20,mM
R4750	T7729	T7730	compound	mM,Hepes
R4751	T7730	T7727	dep	Hepes,CaCl2
R4752	T7731	T7730	punct	", ",Hepes
R4753	T7732	T7730	npadvmod	pH,Hepes
R4754	T7733	T7732	nummod	7.5,pH
R4755	T7734	T7727	punct	", ",CaCl2
R4756	T7735	T7736	nummod	150,mM
R4757	T7736	T7737	compound	mM,NaCl
R4758	T7737	T7727	dep	NaCl,CaCl2
R4759	T7738	T7727	punct	", ",CaCl2
R4760	T7739	T7740	nummod	1,mM
R4761	T7740	T7727	compound	mM,CaCl2
R4762	T7741	T7727	acl	adjusted,CaCl2
R4763	T7742	T7741	prep	to,adjusted
R4764	T7743	T7744	nummod	5,μM
R4765	T7744	T7745	compound	μM,A23187
R4766	T7745	T7742	pobj	A23187,to
R4767	T7746	T7745	compound	Ca2+,A23187
R4768	T7747	T7745	compound	ionophore,A23187
R4769	T7748	T7727	punct	),CaCl2
R4770	T7749	T7711	cc	and,combined
R4771	T7750	T7711	conj	incubated,combined
R4772	T7751	T7750	prep	for,incubated
R4773	T7752	T7753	nummod	30,minutes
R4774	T7753	T7751	pobj	minutes,for
R4775	T7754	T7750	prep	at,incubated
R4776	T7755	T7756	nummod	37,°C
R4777	T7756	T7754	pobj	°C,at
R4778	T7757	T7711	punct	.,combined
R4779	T7759	T7760	prep	After,added
R4780	T7761	T7759	pobj	incubation,After
R4781	T7762	T7760	nsubjpass	EDTA,added
R4782	T7763	T7760	auxpass	was,added
R4783	T7764	T7760	prep	to,added
R4784	T7765	T7766	det	the,solution
R4785	T7766	T7764	pobj	solution,to
R4786	T7767	T7760	prep	to,added
R4787	T7768	T7769	det	a,concentration
R4788	T7769	T7767	pobj	concentration,to
R4789	T7770	T7769	amod	final,concentration
R4790	T7771	T7769	prep	of,concentration
R4791	T7772	T7773	nummod	5,mM
R4792	T7773	T7771	pobj	mM,of
R4793	T7774	T7760	cc	and,added
R4794	T7775	T7760	conj	centrifuged,added
R4795	T7776	T7775	prep	for,centrifuged
R4796	T7777	T7778	nummod	5,minutes
R4797	T7778	T7776	pobj	minutes,for
R4798	T7779	T7775	prep	at,centrifuged
R4799	T7780	T7781	nummod	400,g
R4800	T7781	T7779	pobj	g,at
R4801	T7782	T7781	punct	×,g
R4802	T7783	T7781	cc	and,g
R4803	T7784	T7785	nummod	4,°C
R4804	T7785	T7781	conj	°C,g
R4805	T7786	T7760	punct	.,added
R4806	T7788	T7789	det	The,supernatant
R4807	T7789	T7790	nsubjpass	supernatant,collected
R4808	T7791	T7790	auxpass	was,collected
R4809	T7792	T7790	cc	and,collected
R4810	T7793	T7790	conj	centrifuged,collected
R4811	T7794	T7793	prep	for,centrifuged
R4812	T7795	T7796	nummod	20,minutes
R4813	T7796	T7794	pobj	minutes,for
R4814	T7797	T7793	prep	at,centrifuged
R4815	T7798	T7799	nummod	"15,000",g
R4816	T7799	T7797	pobj	g,at
R4817	T7800	T7799	punct	×,g
R4818	T7801	T7799	cc	and,g
R4819	T7802	T7803	nummod	4,°C
R4820	T7803	T7799	conj	°C,g
R4821	T7804	T7790	punct	.,collected
R4822	T7806	T7807	det	The,pellet
R4823	T7807	T7809	nsubj	pellet,resuspended
R4824	T7808	T7807	amod	resulting,pellet
R4825	T7810	T7809	aux	was,resuspended
R4826	T7811	T7809	prep	in,resuspended
R4827	T7812	T7813	amod	washing,buffer
R4828	T7813	T7811	pobj	buffer,in
R4829	T7814	T7809	cc	and,resuspended
R4830	T7815	T7809	conj	centrifuged,resuspended
R4831	T7816	T7815	prep	at,centrifuged
R4832	T7817	T7818	nummod	400,g
R4833	T7818	T7816	pobj	g,at
R4834	T7819	T7818	punct	×,g
R4835	T7820	T7815	advmod	again,centrifuged
R4836	T7821	T7822	aux	to,collect
R4837	T7822	T7809	advcl	collect,resuspended
R4838	T7823	T7824	det	a,supernatant
R4839	T7824	T7822	dobj	supernatant,collect
R4840	T7825	T7824	acl	enriched,supernatant
R4841	T7826	T7825	prep	with,enriched
R4842	T7827	T7828	amod	red,cell
R4843	T7828	T7830	compound	cell,microvesicles
R4844	T7829	T7828	compound	blood,cell
R4845	T7830	T7826	pobj	microvesicles,with
R4846	T7831	T7809	punct	.,resuspended
R4847	T7833	T7834	det	The,supernatant
R4848	T7834	T7835	nsubjpass	supernatant,centrifuged
R4849	T7836	T7834	prep	of,supernatant
R4850	T7837	T7838	det	the,step
R4851	T7838	T7836	pobj	step,of
R4852	T7839	T7840	nummod	"15,000",g
R4853	T7840	T7838	compound	g,step
R4854	T7841	T7840	punct	×,g
R4855	T7842	T7835	auxpass	was,centrifuged
R4856	T7843	T7835	advmod	further,centrifuged
R4857	T7844	T7835	prep	for,centrifuged
R4858	T7845	T7846	nummod	60,minutes
R4859	T7846	T7844	pobj	minutes,for
R4860	T7847	T7835	prep	at,centrifuged
R4861	T7848	T7849	nummod	"100,000",g
R4862	T7849	T7847	pobj	g,at
R4863	T7850	T7849	punct	×,g
R4864	T7851	T7849	cc	and,g
R4865	T7852	T7853	nummod	4,°C
R4866	T7853	T7849	conj	°C,g
R4867	T7854	T7835	punct	.,centrifuged
R4868	T7856	T7857	det	The,pellet
R4869	T7857	T7859	nsubj	pellet,resuspended
R4870	T7858	T7857	amod	final,pellet
R4871	T7860	T7857	prep	of,pellet
R4872	T7861	T7862	det	this,step
R4873	T7862	T7860	pobj	step,of
R4874	T7863	T7859	aux	was,resuspended
R4875	T7864	T7859	prep	in,resuspended
R4876	T7865	T7866	amod	washing,buffer
R4877	T7866	T7864	pobj	buffer,in
R4878	T7867	T7859	cc	and,resuspended
R4879	T7868	T7859	conj	centrifuged,resuspended
R4880	T7869	T7868	prep	at,centrifuged
R4881	T7870	T7871	nummod	"15,000",g
R4882	T7871	T7869	pobj	g,at
R4883	T7872	T7871	punct	×,g
R4884	T7873	T7868	advmod	again,centrifuged
R4885	T7874	T7875	aux	to,purify
R4886	T7875	T7859	advcl	purify,resuspended
R4887	T7876	T7877	det	a,supernatant
R4888	T7877	T7875	dobj	supernatant,purify
R4889	T7878	T7877	acl	enriched,supernatant
R4890	T7879	T7878	prep	in,enriched
R4891	T7880	T7879	pobj	nanovesicles,in
R4892	T7881	T7875	prep	according,purify
R4893	T7882	T7881	prep	to,according
R4894	T7883	T7882	punct	[,to
R4895	T7884	T7885	nummod	7,20
R4896	T7885	T7882	pobj	20,to
R4897	T7886	T7885	punct	",",20
R4898	T7887	T7859	punct	],resuspended
R4899	T7888	T7859	punct	.,resuspended
R4900	T7890	T7891	det	The,vesicles
R4901	T7891	T7892	nsubjpass	vesicles,assayed
R4902	T7893	T7892	auxpass	were,assayed
R4903	T7894	T7892	prep	for,assayed
R4904	T7895	T7896	compound	acetylcholine,esterase
R4905	T7896	T7897	compound	esterase,activity
R4906	T7897	T7894	pobj	activity,for
R4907	T7898	T7892	cc	and,assayed
R4908	T7899	T7892	conj	used,assayed
R4909	T7900	T7899	prep	for,used
R4910	T7901	T7902	amod	further,analysis
R4911	T7902	T7900	pobj	analysis,for
R4912	T7903	T7892	punct	.,assayed
R4913	T7951	T7952	compound	Acetylcholine,esterase
R4914	T7952	T7953	compound	esterase,assay
R4915	T7955	T7956	det	A,sample
R4916	T7956	T7959	nsubjpass	sample,mixed
R4917	T7957	T7958	nummod	30,μl
R4918	T7958	T7956	compound	μl,sample
R4919	T7960	T7956	prep	of,sample
R4920	T7961	T7962	amod	red,cell
R4921	T7962	T7964	compound	cell,vesicles
R4922	T7963	T7962	compound	blood,cell
R4923	T7964	T7960	pobj	vesicles,of
R4924	T7965	T7959	auxpass	was,mixed
R4925	T7966	T7959	prep	with,mixed
R4926	T7967	T7968	det	an,volume
R4927	T7968	T7966	pobj	volume,with
R4928	T7969	T7968	amod	equal,volume
R4929	T7970	T7968	prep	of,volume
R4930	T7971	T7970	pobj	buffer,of
R4931	T7972	T7973	punct	(,X
R4932	T7973	T7971	parataxis	X,buffer
R4933	T7974	T7975	nummod	20,mM
R4934	T7975	T7976	compound	mM,Hepes
R4935	T7976	T7973	dep	Hepes,X
R4936	T7977	T7976	punct	", ",Hepes
R4937	T7978	T7976	npadvmod	pH,Hepes
R4938	T7979	T7978	nummod	7.6,pH
R4939	T7980	T7973	punct	", ",X
R4940	T7981	T7982	nummod	150,mM
R4941	T7982	T7983	compound	mM,NaCl
R4942	T7983	T7973	dep	NaCl,X
R4943	T7984	T7973	punct	", ",X
R4944	T7985	T7986	nummod	0.5,%
R4945	T7986	T7973	compound	%,X
R4946	T7987	T7973	compound	Triton,X
R4947	T7988	T7973	punct	-,X
R4948	T7989	T7973	nummod	100,X
R4949	T7990	T7973	punct	),X
R4950	T7991	T7959	punct	", ",mixed
R4951	T7992	T7959	conj	vortexed,mixed
R4952	T7993	T7992	cc	and,vortexed
R4953	T7994	T7992	conj	incubated,vortexed
R4954	T7995	T7994	prep	for,incubated
R4955	T7996	T7997	nummod	5,minutes
R4956	T7997	T7995	pobj	minutes,for
R4957	T7998	T7994	prep	at,incubated
R4958	T7999	T8000	nummod	37,°C
R4959	T8000	T7998	pobj	°C,at
R4960	T8001	T7959	punct	.,mixed
R4961	T8003	T8004	advmod	Subsequently,added
R4962	T8005	T8006	nummod	640,μl
R4963	T8006	T8007	compound	μl,buffer
R4964	T8007	T8004	nsubjpass	buffer,added
R4965	T8008	T8009	compound	sodium,phosphate
R4966	T8009	T8007	compound	phosphate,buffer
R4967	T8010	T8011	punct	(,Na2PO4
R4968	T8011	T8007	parataxis	Na2PO4,buffer
R4969	T8012	T8013	nummod	100,mM
R4970	T8013	T8011	compound	mM,Na2PO4
R4971	T8014	T8011	punct	", ",Na2PO4
R4972	T8015	T8011	npadvmod	pH,Na2PO4
R4973	T8016	T8015	nummod	7.6,pH
R4974	T8017	T8011	punct	),Na2PO4
R4975	T8018	T8007	punct	", ",buffer
R4976	T8019	T8020	nummod	50,μl
R4977	T8020	T8021	compound	μl,DTNB
R4978	T8021	T8007	conj	DTNB,buffer
R4979	T8022	T8023	punct	(,mM
R4980	T8023	T8021	parataxis	mM,DTNB
R4981	T8024	T8025	nummod	5,dithiobis
R4982	T8025	T8023	dep	dithiobis,mM
R4983	T8026	T8025	punct	",",dithiobis
R4984	T8027	T8025	nummod	5,dithiobis
R4985	T8028	T8027	punct	',5
R4986	T8029	T8025	punct	-,dithiobis
R4987	T8030	T8023	punct	-,mM
R4988	T8031	T8032	punct	(,acid
R4989	T8032	T8023	parataxis	acid,mM
R4990	T8033	T8032	nummod	2,acid
R4991	T8034	T8032	punct	-,acid
R4992	T8035	T8032	amod	nitrobenzoic,acid
R4993	T8036	T8032	punct	),acid
R4994	T8037	T8023	punct	", ",mM
R4995	T8038	T8023	nummod	10,mM
R4996	T8039	T8023	prep	in,mM
R4997	T8040	T8041	compound	sodium,phosphate
R4998	T8041	T8042	compound	phosphate,buffer
R4999	T8042	T8039	pobj	buffer,in
R5000	T8043	T8023	punct	),mM
R5001	T8044	T8021	punct	", ",DTNB
R5002	T8045	T8021	cc	and,DTNB
R5003	T8046	T8047	nummod	50,μl
R5004	T8047	T8048	compound	μl,chloride
R5005	T8048	T8021	conj	chloride,DTNB
R5006	T8049	T8048	compound	acetylthiocholine,chloride
R5007	T8050	T8051	punct	(,mM
R5008	T8051	T8048	parataxis	mM,chloride
R5009	T8052	T8051	nummod	12,mM
R5010	T8053	T8051	punct	",",mM
R5011	T8054	T8051	nummod	5,mM
R5012	T8055	T8051	prep	in,mM
R5013	T8056	T8055	pobj	H2O,in
R5014	T8057	T8051	punct	),mM
R5015	T8058	T8004	auxpass	were,added
R5016	T8059	T8004	punct	.,added
R5017	T8061	T8062	det	The,reaction
R5018	T8062	T8063	nsubj	reaction,took
R5019	T8064	T8063	dobj	place,took
R5020	T8065	T8063	prep	at,took
R5021	T8066	T8067	compound	room,temperature
R5022	T8067	T8065	pobj	temperature,at
R5023	T8068	T8063	cc	and,took
R5024	T8069	T8070	auxpass	was,measured
R5025	T8070	T8063	conj	measured,took
R5026	T8071	T8070	advmod	photometrically,measured
R5027	T8072	T8070	prep	at,measured
R5028	T8073	T8074	det	a,wavelength
R5029	T8074	T8072	pobj	wavelength,at
R5030	T8075	T8074	prep	of,wavelength
R5031	T8076	T8077	nummod	405,nm
R5032	T8077	T8075	pobj	nm,of
R5033	T8078	T8070	prep	according,measured
R5034	T8079	T8078	prep	to,according
R5035	T8080	T8081	det	the,method
R5036	T8081	T8079	pobj	method,to
R5037	T8082	T8081	nmod	Ellmann,method
R5038	T8083	T8081	case	',method
R5039	T8084	T8085	punct	[,25
R5040	T8085	T8070	parataxis	25,measured
R5041	T8086	T8085	punct	],25
R5042	T8087	T8063	punct	.,took
R5043	T8114	T8113	prep	of,Determination
R5044	T8115	T8116	det	the,resistance
R5045	T8116	T8114	pobj	resistance,of
R5046	T8117	T8116	amod	osmotic,resistance
R5047	T8118	T8116	prep	of,resistance
R5048	T8119	T8120	amod	red,cells
R5049	T8120	T8118	pobj	cells,of
R5050	T8121	T8120	compound	blood,cells
R5051	T8123	T8124	det	A,gradient
R5052	T8124	T8130	nsubjpass	gradient,used
R5053	T8125	T8126	compound	Na2HPO4,NaH2PO4
R5054	T8126	T8128	npadvmod	NaH2PO4,buffered
R5055	T8127	T8126	punct	/,NaH2PO4
R5056	T8128	T8124	amod	buffered,gradient
R5057	T8129	T8124	compound	NaCl,gradient
R5058	T8131	T8132	punct	(,pH
R5059	T8132	T8124	npadvmod	pH,gradient
R5060	T8133	T8132	nummod	7.4,pH
R5061	T8134	T8132	punct	),pH
R5062	T8135	T8124	acl	comprised,gradient
R5063	T8136	T8135	prep	of,comprised
R5064	T8137	T8138	det	the,steps
R5065	T8138	T8136	pobj	steps,of
R5066	T8139	T8138	amod	following,steps
R5067	T8140	T8138	compound	NaCl,steps
R5068	T8141	T8130	auxpass	was,used
R5069	T8142	T8130	prep	for,used
R5070	T8143	T8144	det	this,assay
R5071	T8144	T8142	pobj	assay,for
R5072	T8145	T8130	punct	: ,used
R5073	T8146	T8147	nummod	0.90,%
R5074	T8147	T8130	dobj	%,used
R5075	T8148	T8147	punct	", ",%
R5076	T8149	T8150	nummod	0.65,%
R5077	T8150	T8147	appos	%,%
R5078	T8151	T8147	punct	", ",%
R5079	T8152	T8153	nummod	0.60,%
R5080	T8153	T8147	appos	%,%
R5081	T8154	T8147	punct	", ",%
R5082	T8155	T8156	nummod	0.55,%
R5083	T8156	T8147	appos	%,%
R5084	T8157	T8147	punct	", ",%
R5085	T8158	T8159	nummod	0.50,%
R5086	T8159	T8147	appos	%,%
R5087	T8160	T8147	punct	", ",%
R5088	T8161	T8162	nummod	0.45,%
R5089	T8162	T8147	appos	%,%
R5090	T8163	T8147	punct	", ",%
R5091	T8164	T8165	nummod	0.40,%
R5092	T8165	T8147	appos	%,%
R5093	T8166	T8147	punct	", ",%
R5094	T8167	T8168	nummod	0.35,%
R5095	T8168	T8147	appos	%,%
R5096	T8169	T8147	punct	", ",%
R5097	T8170	T8171	nummod	0.30,%
R5098	T8171	T8147	appos	%,%
R5099	T8172	T8147	punct	", ",%
R5100	T8173	T8174	nummod	0.10,%
R5101	T8174	T8147	appos	%,%
R5102	T8175	T8130	punct	.,used
R5103	T8177	T8178	prep	For,inverted
R5104	T8179	T8180	det	each,step
R5105	T8180	T8177	pobj	step,For
R5106	T8181	T8182	nummod	5,ml
R5107	T8182	T8178	nsubjpass	ml,inverted
R5108	T8183	T8182	prep	of,ml
R5109	T8184	T8185	det	the,solution
R5110	T8185	T8183	pobj	solution,of
R5111	T8186	T8185	compound	gradient,solution
R5112	T8187	T8185	compound	step,solution
R5113	T8188	T8182	cc	and,ml
R5114	T8189	T8190	nummod	50,μl
R5115	T8190	T8191	compound	μl,sample
R5116	T8191	T8182	conj	sample,ml
R5117	T8192	T8191	compound	blood,sample
R5118	T8193	T8178	auxpass	were,inverted
R5119	T8194	T8178	advmod	carefully,inverted
R5120	T8195	T8196	nummod	four,times
R5121	T8196	T8178	npadvmod	times,inverted
R5122	T8197	T8178	cc	and,inverted
R5123	T8198	T8178	conj	incubated,inverted
R5124	T8199	T8198	prep	for,incubated
R5125	T8200	T8201	nummod	30,minutes
R5126	T8201	T8199	pobj	minutes,for
R5127	T8202	T8198	prep	in,incubated
R5128	T8203	T8204	det	the,dark
R5129	T8204	T8202	pobj	dark,in
R5130	T8205	T8178	punct	.,inverted
R5131	T8207	T8208	nsubjpass	Samples,inverted
R5132	T8209	T8208	auxpass	were,inverted
R5133	T8210	T8208	advmod	carefully,inverted
R5134	T8211	T8208	advmod	again,inverted
R5135	T8212	T8208	cc	and,inverted
R5136	T8213	T8208	conj	centrifuged,inverted
R5137	T8214	T8213	prep	at,centrifuged
R5138	T8215	T8216	nummod	"1,500",g
R5139	T8216	T8214	pobj	g,at
R5140	T8217	T8216	punct	×,g
R5141	T8218	T8213	prep	for,centrifuged
R5142	T8219	T8220	nummod	10,minutes
R5143	T8220	T8218	pobj	minutes,for
R5144	T8221	T8208	punct	.,inverted
R5145	T8223	T8224	prep	From,measured
R5146	T8225	T8226	nummod	1,ml
R5147	T8226	T8227	compound	ml,supernatant
R5148	T8227	T8223	pobj	supernatant,From
R5149	T8228	T8227	prep	of,supernatant
R5150	T8229	T8230	det	each,step
R5151	T8230	T8228	pobj	step,of
R5152	T8231	T8232	det	the,extinction
R5153	T8232	T8224	nsubjpass	extinction,measured
R5154	T8233	T8232	prep	at,extinction
R5155	T8234	T8235	nummod	546,nm
R5156	T8235	T8236	compound	nm,wavelength
R5157	T8236	T8233	pobj	wavelength,at
R5158	T8237	T8224	auxpass	was,measured
R5159	T8238	T8224	punct	.,measured
R5160	T8240	T8241	det	The,experiment
R5161	T8241	T8242	nsubjpass	experiment,performed
R5162	T8243	T8242	auxpass	was,performed
R5163	T8244	T8242	prep	at,performed
R5164	T8245	T8246	compound	room,temperature
R5165	T8246	T8244	pobj	temperature,at
R5166	T8247	T8242	punct	.,performed
R5167	T8326	T8327	compound	Platelet,aggregation
R5168	T8327	T8328	compound	aggregation,assay
R5169	T8330	T8331	advmod	Approximately,500
R5170	T8331	T8332	nummod	500,μl
R5171	T8332	T8333	nsubjpass	μl,centrifuged
R5172	T8334	T8332	prep	of,μl
R5173	T8335	T8336	amod	murine,blood
R5174	T8336	T8334	pobj	blood,of
R5175	T8337	T8333	auxpass	were,centrifuged
R5176	T8338	T8333	prep	at,centrifuged
R5177	T8339	T8340	nummod	200,g
R5178	T8340	T8338	pobj	g,at
R5179	T8341	T8340	punct	×,g
R5180	T8342	T8333	prep	for,centrifuged
R5181	T8343	T8344	nummod	15,minutes
R5182	T8344	T8342	pobj	minutes,for
R5183	T8345	T8333	punct	.,centrifuged
R5184	T8347	T8348	det	The,supernatants
R5185	T8348	T8350	nsubjpass	supernatants,transferred
R5186	T8349	T8348	amod	resulting,supernatants
R5187	T8351	T8350	auxpass	were,transferred
R5188	T8352	T8350	prep	to,transferred
R5189	T8353	T8354	amod	new,tubes
R5190	T8354	T8352	pobj	tubes,to
R5191	T8355	T8350	cc	and,transferred
R5192	T8356	T8350	conj	used,transferred
R5193	T8357	T8356	prep	as,used
R5194	T8358	T8359	npadvmod	platelet,rich
R5195	T8359	T8360	amod	rich,plasma
R5196	T8360	T8357	pobj	plasma,as
R5197	T8361	T8360	punct	(,plasma
R5198	T8362	T8360	appos	PRP,plasma
R5199	T8363	T8350	punct	),transferred
R5200	T8364	T8350	punct	.,transferred
R5201	T8366	T8367	det	The,measurements
R5202	T8367	T8370	nsubjpass	measurements,done
R5203	T8368	T8369	compound	platelet,aggregation
R5204	T8369	T8367	compound	aggregation,measurements
R5205	T8371	T8370	auxpass	were,done
R5206	T8372	T8370	prep	according,done
R5207	T8373	T8372	prep	to,according
R5208	T8374	T8375	det	the,method
R5209	T8375	T8373	pobj	method,to
R5210	T8376	T8375	acl	developed,method
R5211	T8377	T8376	agent	by,developed
R5212	T8378	T8377	pobj	Born,by
R5213	T8379	T8378	cc	and,Born
R5214	T8380	T8378	conj	Cross,Born
R5215	T8381	T8382	punct	[,26
R5216	T8382	T8380	parataxis	26,Cross
R5217	T8383	T8382	punct	],26
R5218	T8384	T8370	advcl	using,done
R5219	T8385	T8386	det	an,photometer
R5220	T8386	T8384	dobj	photometer,using
R5221	T8387	T8386	compound	APACT,photometer
R5222	T8388	T8389	punct	(,FRG
R5223	T8389	T8386	parataxis	FRG,photometer
R5224	T8390	T8389	dep	Labor,FRG
R5225	T8391	T8389	punct	", ",FRG
R5226	T8392	T8389	dep	Ahrendsburg,FRG
R5227	T8393	T8389	punct	", ",FRG
R5228	T8394	T8389	punct	),FRG
R5229	T8395	T8386	cc	and,photometer
R5230	T8396	T8397	det	the,software
R5231	T8397	T8386	conj	software,photometer
R5232	T8398	T8397	compound	APACT,software
R5233	T8399	T8400	punct	(,APACT
R5234	T8400	T8397	parataxis	APACT,software
R5235	T8401	T8400	nummod	1.4,APACT
R5236	T8402	T8400	punct	),APACT
R5237	T8403	T8370	punct	.,done
R5238	T8405	T8406	advmod	Subsequently,adjusted
R5239	T8407	T8406	nsubjpass	samples,adjusted
R5240	T8408	T8407	prep	of,samples
R5241	T8409	T8410	det	the,PRP
R5242	T8410	T8408	pobj	PRP,of
R5243	T8411	T8406	auxpass	were,adjusted
R5244	T8412	T8406	prep	with,adjusted
R5245	T8413	T8412	pobj	buffer,with
R5246	T8414	T8415	punct	(,pH
R5247	T8415	T8413	parataxis	pH,buffer
R5248	T8416	T8417	nummod	5,mM
R5249	T8417	T8418	compound	mM,Hepes
R5250	T8418	T8415	dep	Hepes,pH
R5251	T8419	T8415	punct	", ",pH
R5252	T8420	T8421	nummod	150,mM
R5253	T8421	T8422	compound	mM,NaCl
R5254	T8422	T8415	dep	NaCl,pH
R5255	T8423	T8415	punct	", ",pH
R5256	T8424	T8415	nummod	7.3,pH
R5257	T8425	T8415	punct	),pH
R5258	T8426	T8406	prep	to,adjusted
R5259	T8427	T8428	nummod	"250,000",platelets
R5260	T8428	T8426	pobj	platelets,to
R5261	T8429	T8430	punct	/,μl
R5262	T8430	T8428	prep	μl,platelets
R5263	T8431	T8406	punct	.,adjusted
R5264	T8433	T8434	det	A,count
R5265	T8434	T8437	nsubjpass	count,used
R5266	T8435	T8434	amod	constant,count
R5267	T8436	T8434	compound	platelet,count
R5268	T8438	T8437	auxpass	was,used
R5269	T8439	T8437	advmod	throughout,used
R5270	T8440	T8437	advcl	allowing,used
R5271	T8441	T8440	dobj	comparisons,allowing
R5272	T8442	T8441	prep	between,comparisons
R5273	T8443	T8444	amod	wild,type
R5274	T8444	T8445	nmod	type,samples
R5275	T8445	T8442	pobj	samples,between
R5276	T8446	T8444	cc	and,type
R5277	T8447	T8448	compound	knock,out
R5278	T8448	T8444	conj	out,type
R5279	T8449	T8445	amod	murine,samples
R5280	T8450	T8449	cc	and,murine
R5281	T8451	T8449	conj	human,murine
R5282	T8452	T8437	punct	.,used
R5283	T8454	T8455	nummod	250,μl
R5284	T8455	T8456	nmod	μl,platelets
R5285	T8456	T8458	nsubjpass	platelets,prewarmed
R5286	T8457	T8456	amod	adjusted,platelets
R5287	T8459	T8458	auxpass	were,prewarmed
R5288	T8460	T8458	prep	to,prewarmed
R5289	T8461	T8462	nummod	37,°C
R5290	T8462	T8460	pobj	°C,to
R5291	T8463	T8458	cc	and,prewarmed
R5292	T8464	T8458	conj	used,prewarmed
R5293	T8465	T8464	prep	in,used
R5294	T8466	T8467	det	the,assay
R5295	T8467	T8465	pobj	assay,in
R5296	T8468	T8458	punct	", ",prewarmed
R5297	T8469	T8458	cc	and,prewarmed
R5298	T8470	T8471	det	the,process
R5299	T8471	T8473	nsubjpass	process,started
R5300	T8472	T8471	compound	aggregation,process
R5301	T8473	T8458	conj	started,prewarmed
R5302	T8474	T8473	auxpass	was,started
R5303	T8475	T8473	prep	by,started
R5304	T8476	T8475	pcomp	adding,by
R5305	T8477	T8478	nummod	25,μl
R5306	T8478	T8476	dobj	μl,adding
R5307	T8479	T8478	prep	of,μl
R5308	T8480	T8481	det	a,solution
R5309	T8481	T8479	pobj	solution,of
R5310	T8482	T8481	amod	prewarmed,solution
R5311	T8483	T8484	nummod	16.5,mg
R5312	T8484	T8481	nmod	mg,solution
R5313	T8485	T8486	punct	/,ml
R5314	T8486	T8484	prep	ml,mg
R5315	T8487	T8481	compound	ristocetin,solution
R5316	T8488	T8489	punct	(,FRG
R5317	T8489	T8481	parataxis	FRG,solution
R5318	T8490	T8491	compound	DiaMed,Diagnostica
R5319	T8491	T8489	dep	Diagnostica,FRG
R5320	T8492	T8489	punct	", ",FRG
R5321	T8493	T8489	dep	Bensheim,FRG
R5322	T8494	T8489	punct	", ",FRG
R5323	T8495	T8489	punct	;,FRG
R5324	T8496	T8497	dep	concentration,mg
R5325	T8497	T8489	dep	mg,FRG
R5326	T8498	T8496	prep	in,concentration
R5327	T8499	T8500	det	the,assay
R5328	T8500	T8498	pobj	assay,in
R5329	T8501	T8497	punct	: ,mg
R5330	T8502	T8497	nummod	1.5,mg
R5331	T8503	T8504	punct	/,ml
R5332	T8504	T8497	prep	ml,mg
R5333	T8505	T8489	punct	),FRG
R5334	T8506	T8481	punct	", ",solution
R5335	T8507	T8508	det	a,reagent
R5336	T8508	T8481	appos	reagent,solution
R5337	T8509	T8510	dep	which,worked
R5338	T8510	T8508	relcl	worked,reagent
R5339	T8511	T8510	advmod	reliably,worked
R5340	T8512	T8510	prep	in,worked
R5341	T8513	T8514	poss	our,hands
R5342	T8514	T8512	pobj	hands,in
R5343	T8515	T8510	prep	with,worked
R5344	T8516	T8517	nmod	mouse,platelets
R5345	T8517	T8515	pobj	platelets,with
R5346	T8518	T8516	cc	and,mouse
R5347	T8519	T8516	conj	human,mouse
R5348	T8520	T8473	punct	.,started
R5349	T8522	T8523	det	Each,assay
R5350	T8523	T8525	nsubj	assay,represents
R5351	T8524	T8523	amod	murine,assay
R5352	T8526	T8527	det	a,animal
R5353	T8527	T8525	dobj	animal,represents
R5354	T8528	T8527	amod	different,animal
R5355	T8529	T8525	punct	.,represents
R5356	T8531	T8532	nsubjpass	Analyses,performed
R5357	T8533	T8531	prep	of,Analyses
R5358	T8534	T8535	amod	human,samples
R5359	T8535	T8533	pobj	samples,of
R5360	T8536	T8535	compound	blood,samples
R5361	T8537	T8532	auxpass	were,performed
R5362	T8538	T8539	mark	as,described
R5363	T8539	T8532	advcl	described,performed
R5364	T8540	T8539	prep	in,described
R5365	T8541	T8542	det	the,manufacturer
R5366	T8542	T8543	poss	manufacturer,protocol
R5367	T8543	T8540	pobj	protocol,in
R5368	T8544	T8542	case	's,manufacturer
R5369	T8545	T8532	punct	.,performed
R5370	T8547	T8548	amod	Several,measurements
R5371	T8548	T8550	nsubjpass	measurements,done
R5372	T8549	T8548	amod	repeated,measurements
R5373	T8551	T8550	auxpass	were,done
R5374	T8552	T8550	prep	per,done
R5375	T8553	T8554	amod	human,individual
R5376	T8554	T8552	pobj	individual,per
R5377	T8555	T8556	aux	to,control
R5378	T8556	T8550	advcl	control,done
R5379	T8557	T8558	det	the,reproducibility
R5380	T8558	T8556	dobj	reproducibility,control
R5381	T8559	T8550	punct	.,done
R5382	T8561	T8562	det	The,data
R5383	T8562	T8566	nsubjpass	data,analysed
R5384	T8563	T8562	amod	acquired,data
R5385	T8564	T8565	compound	aggregation,curve
R5386	T8565	T8562	compound	curve,data
R5387	T8567	T8562	punct	", ",data
R5388	T8568	T8562	acl	measured,data
R5389	T8569	T8568	prep	as,measured
R5390	T8570	T8571	amod	ascending,degree
R5391	T8571	T8569	pobj	degree,as
R5392	T8572	T8571	prep	of,degree
R5393	T8573	T8572	pobj	transmission,of
R5394	T8574	T8566	punct	", ",analysed
R5395	T8575	T8566	auxpass	were,analysed
R5396	T8576	T8566	prep	for,analysed
R5397	T8577	T8578	amod	maximal,values
R5398	T8578	T8576	pobj	values,for
R5399	T8579	T8578	compound	slope,values
R5400	T8580	T8566	punct	", ",analysed
R5401	T8581	T8582	prep	while,set
R5402	T8582	T8566	advcl	set,analysed
R5403	T8583	T8584	det	the,amplitude
R5404	T8584	T8582	nsubjpass	amplitude,set
R5405	T8585	T8584	amod	maximal,amplitude
R5406	T8586	T8584	compound	aggregation,amplitude
R5407	T8587	T8584	prep	of,amplitude
R5408	T8588	T8589	det	every,curve
R5409	T8589	T8587	pobj	curve,of
R5410	T8590	T8589	amod	single,curve
R5411	T8591	T8582	auxpass	was,set
R5412	T8592	T8582	prep	to,set
R5413	T8593	T8594	nummod	100,%
R5414	T8594	T8592	pobj	%,to
R5415	T8595	T8566	punct	.,analysed
R5416	T8597	T8598	prep	In,done
R5417	T8599	T8597	amod	general,In
R5418	T8600	T8598	punct	", ",done
R5419	T8601	T8602	det	all,procedures
R5420	T8602	T8598	nsubjpass	procedures,done
R5421	T8603	T8602	compound	platelet,procedures
R5422	T8604	T8598	auxpass	were,done
R5423	T8605	T8598	prep	at,done
R5424	T8606	T8607	nummod	22,°C
R5425	T8607	T8605	pobj	°C,at
R5426	T8608	T8598	prep	within,done
R5427	T8609	T8610	nummod	four,hours
R5428	T8610	T8608	pobj	hours,within
R5429	T8611	T8610	prep	after,hours
R5430	T8612	T8611	pcomp	collecting,after
R5431	T8613	T8614	det	the,sample
R5432	T8614	T8612	dobj	sample,collecting
R5433	T8615	T8614	compound	blood,sample
R5434	T8616	T8598	punct	.,done
R5435	T8735	T8736	amod	Miscellaneous,methods
R5436	T8738	T8739	prep	For,analysed
R5437	T8740	T8741	amod	standard,measurements
R5438	T8741	T8738	pobj	measurements,For
R5439	T8742	T8741	amod	haematopoetic,measurements
R5440	T8743	T8741	cc	and,measurements
R5441	T8744	T8745	compound	cell,counts
R5442	T8745	T8741	conj	counts,measurements
R5443	T8746	T8741	prep	on,measurements
R5444	T8747	T8748	nmod	murine,samples
R5445	T8748	T8746	pobj	samples,on
R5446	T8749	T8747	cc	and,murine
R5447	T8750	T8747	conj	human,murine
R5448	T8751	T8748	compound	blood,samples
R5449	T8752	T8753	quantmod	about,300
R5450	T8753	T8754	nummod	300,μl
R5451	T8754	T8739	nsubjpass	μl,analysed
R5452	T8755	T8754	prep	of,μl
R5453	T8756	T8755	pobj	blood,of
R5454	T8757	T8739	auxpass	were,analysed
R5455	T8758	T8739	prep	with,analysed
R5456	T8759	T8760	det	an,counter
R5457	T8760	T8758	pobj	counter,with
R5458	T8761	T8760	nmod	ADVIA,counter
R5459	T8762	T8761	nummod	120,ADVIA
R5460	T8763	T8760	amod	electronic,counter
R5461	T8764	T8760	compound	cell,counter
R5462	T8765	T8766	punct	(,Bayer
R5463	T8766	T8760	parataxis	Bayer,counter
R5464	T8767	T8766	punct	),Bayer
R5465	T8768	T8739	punct	.,analysed
R5466	T8770	T8771	prep	With,transformed
R5467	T8772	T8773	det	this,equipment
R5468	T8773	T8770	pobj	equipment,With
R5469	T8774	T8775	amod	red,cells
R5470	T8775	T8771	nsubjpass	cells,transformed
R5471	T8776	T8775	compound	blood,cells
R5472	T8777	T8775	cc	and,cells
R5473	T8778	T8775	conj	platelets,cells
R5474	T8779	T8771	auxpass	are,transformed
R5475	T8780	T8771	punct	"""",transformed
R5476	T8781	T8771	punct	"""",transformed
R5477	T8782	T8771	prep	into,transformed
R5478	T8783	T8784	amod	spherical,bodies
R5479	T8784	T8782	pobj	bodies,into
R5480	T8785	T8771	prep	without,transformed
R5481	T8786	T8785	pcomp	changing,without
R5482	T8787	T8788	poss	their,volume
R5483	T8788	T8786	dobj	volume,changing
R5484	T8789	T8771	punct	.,transformed
R5485	T8791	T8792	advmod	Therefore,are
R5486	T8793	T8792	nsubj	number,are
R5487	T8794	T8793	cc	and,number
R5488	T8795	T8793	conj	volume,number
R5489	T8796	T8793	prep	of,number
R5490	T8797	T8798	amod	red,cells
R5491	T8798	T8796	pobj	cells,of
R5492	T8799	T8798	compound	blood,cells
R5493	T8800	T8798	cc	and,cells
R5494	T8801	T8798	conj	platelets,cells
R5495	T8802	T8792	neg	not,are
R5496	T8803	T8804	amod	calculated,values
R5497	T8804	T8792	attr	values,are
R5498	T8805	T8792	punct	", ",are
R5499	T8806	T8792	cc	but,are
R5500	T8807	T8808	advmod	directly,measured
R5501	T8808	T8809	amod	measured,values
R5502	T8809	T8792	conj	values,are
R5503	T8810	T8792	punct	.,are
R5504	T8812	T8813	det	The,data
R5505	T8813	T8815	nsubjpass	data,analysed
R5506	T8814	T8813	amod	following,data
R5507	T8816	T8815	auxpass	were,analysed
R5508	T8817	T8815	advmod	statistically,analysed
R5509	T8818	T8815	punct	: ,analysed
R5510	T8819	T8815	dobj	leucocytes,analysed
R5511	T8820	T8819	punct	", ",leucocytes
R5512	T8821	T8822	amod	red,cells
R5513	T8822	T8819	appos	cells,leucocytes
R5514	T8823	T8822	compound	blood,cells
R5515	T8824	T8819	punct	", ",leucocytes
R5516	T8825	T8819	appos	haemoglobin,leucocytes
R5517	T8826	T8819	punct	", ",leucocytes
R5518	T8827	T8819	appos	haematocrit,leucocytes
R5519	T8828	T8819	punct	", ",leucocytes
R5520	T8829	T8830	amod	mean,volume
R5521	T8830	T8819	appos	volume,leucocytes
R5522	T8831	T8830	amod	cellular,volume
R5523	T8832	T8819	punct	", ",leucocytes
R5524	T8833	T8834	amod	mean,haemoglobin
R5525	T8834	T8819	appos	haemoglobin,leucocytes
R5526	T8835	T8834	amod	cellular,haemoglobin
R5527	T8836	T8819	punct	", ",leucocytes
R5528	T8837	T8838	amod	mean,haemoglobin
R5529	T8838	T8840	compound	haemoglobin,concentration
R5530	T8839	T8838	amod	cellular,haemoglobin
R5531	T8840	T8819	appos	concentration,leucocytes
R5532	T8841	T8819	punct	", ",leucocytes
R5533	T8842	T8843	compound	platelet,number
R5534	T8843	T8819	appos	number,leucocytes
R5535	T8844	T8819	punct	", ",leucocytes
R5536	T8845	T8819	appos	neutrophiles,leucocytes
R5537	T8846	T8819	punct	", ",leucocytes
R5538	T8847	T8819	appos	lymphocytes,leucocytes
R5539	T8848	T8819	punct	", ",leucocytes
R5540	T8849	T8819	appos	monocytes,leucocytes
R5541	T8850	T8819	punct	", ",leucocytes
R5542	T8851	T8819	appos	eosinophiles,leucocytes
R5543	T8852	T8819	punct	", ",leucocytes
R5544	T8853	T8819	appos	basophiles,leucocytes
R5545	T8854	T8815	punct	.,analysed
R5546	T8856	T8857	compound	Peptide,mass
R5547	T8857	T8858	compound	mass,fingerprinting
R5548	T8858	T8859	nsubjpass	fingerprinting,performed
R5549	T8860	T8859	auxpass	was,performed
R5550	T8861	T8859	prep	on,performed
R5551	T8862	T8863	det	a,spectrometer
R5552	T8863	T8861	pobj	spectrometer,on
R5553	T8864	T8865	nmod	Bruker,Reflex
R5554	T8865	T8863	nmod	Reflex,spectrometer
R5555	T8866	T8865	nummod	IV,Reflex
R5556	T8867	T8868	compound	MALDI,TOF
R5557	T8868	T8863	compound	TOF,spectrometer
R5558	T8869	T8868	punct	-,TOF
R5559	T8870	T8863	compound	mass,spectrometer
R5560	T8871	T8859	punct	.,performed
R5561	T8873	T8874	amod	Recombinant,A7
R5562	T8874	T8876	nsubjpass	A7,purified
R5563	T8875	T8874	compound	annexin,A7
R5564	T8876	T8878	ccomp	purified,done
R5565	T8877	T8876	auxpass	was,purified
R5566	T8879	T8876	prep	according,purified
R5567	T8880	T8879	prep	to,according
R5568	T8881	T8880	punct	[,to
R5569	T8882	T8880	pobj	27,to
R5570	T8883	T8878	punct	],done
R5571	T8884	T8878	punct	", ",done
R5572	T8885	T8886	compound	F,actin
R5573	T8886	T8878	nsubjpass	actin,done
R5574	T8887	T8886	punct	-,actin
R5575	T8888	T8886	punct	-,actin
R5576	T8889	T8886	amod	binding,actin
R5577	T8890	T8886	prep	of,actin
R5578	T8891	T8892	amod	recombinant,A7
R5579	T8892	T8890	pobj	A7,of
R5580	T8893	T8892	compound	annexin,A7
R5581	T8894	T8878	auxpass	was,done
R5582	T8895	T8896	mark	as,described
R5583	T8896	T8878	advcl	described,done
R5584	T8897	T8898	punct	[,28
R5585	T8898	T8878	parataxis	28,done
R5586	T8899	T8898	punct	],28
R5587	T8900	T8878	punct	.,done
R5588	T8902	T8903	compound	SDS,PAGE
R5589	T8903	T8905	nsubjpass	PAGE,done
R5590	T8904	T8903	punct	-,PAGE
R5591	T8906	T8903	cc	and,PAGE
R5592	T8907	T8908	amod	western,blotting
R5593	T8908	T8903	conj	blotting,PAGE
R5594	T8909	T8905	auxpass	were,done
R5595	T8910	T8911	mark	as,described
R5596	T8911	T8905	advcl	described,done
R5597	T8912	T8913	punct	[,30
R5598	T8913	T8905	parataxis	30,done
R5599	T8914	T8913	nummod	29,30
R5600	T8915	T8913	punct	",",30
R5601	T8916	T8913	punct	],30
R5602	T8917	T8905	punct	.,done
R5603	T8919	T8920	nsubj	Detection,was
R5604	T8921	T8919	prep	in,Detection
R5605	T8922	T8921	pobj	immunoblots,in
R5606	T8923	T8920	prep	with,was
R5607	T8924	T8925	amod	enhanced,chemiluminescence
R5608	T8925	T8923	pobj	chemiluminescence,with
R5609	T8926	T8927	punct	[,17
R5610	T8927	T8920	parataxis	17,was
R5611	T8928	T8927	punct	],17
R5612	T8929	T8920	punct	.,was
R5613	T8931	T8932	nsubj	Antibodies,were
R5614	T8933	T8931	acl	employed,Antibodies
R5615	T8934	T8935	nmod	mab,203
R5616	T8935	T8932	attr	203,were
R5617	T8936	T8937	punct	–,217
R5618	T8937	T8935	prep	217,203
R5619	T8938	T8935	acl	directed,203
R5620	T8939	T8938	prep	against,directed
R5621	T8940	T8941	compound	mouse,domain
R5622	T8941	T8939	pobj	domain,against
R5623	T8942	T8943	compound	annexin,A7
R5624	T8943	T8941	compound	A7,domain
R5625	T8944	T8941	compound	core,domain
R5626	T8945	T8946	punct	[,5
R5627	T8946	T8941	parataxis	5,domain
R5628	T8947	T8946	punct	],5
R5629	T8948	T8941	cc	and,domain
R5630	T8949	T8950	det	a,antibody
R5631	T8950	T8941	conj	antibody,domain
R5632	T8951	T8950	amod	polyclonal,antibody
R5633	T8952	T8950	nmod	rabbit,antibody
R5634	T8953	T8950	amod	anti-sorcin,antibody
R5635	T8954	T8955	punct	[,31
R5636	T8955	T8950	parataxis	31,antibody
R5637	T8956	T8955	punct	],31
R5638	T8957	T8932	punct	.,were
R5639	T8959	T8960	prep	For,performed
R5640	T8961	T8962	amod	statistical,analyses
R5641	T8962	T8959	pobj	analyses,For
R5642	T8963	T8964	det	the,tests
R5643	T8964	T8960	nsubjpass	tests,performed
R5644	T8965	T8964	amod	following,tests
R5645	T8966	T8960	auxpass	were,performed
R5646	T8967	T8960	punct	: ,performed
R5647	T8968	T8969	nmod	David,test
R5648	T8969	T8960	dobj	test,performed
R5649	T8970	T8971	advmod	et,al.
R5650	T8971	T8968	advmod	al.,David
R5651	T8972	T8969	compound	range,test
R5652	T8973	T8974	aux	to,ensure
R5653	T8974	T8969	advcl	ensure,test
R5654	T8975	T8976	nsubj	samples,are
R5655	T8976	T8974	advcl	are,ensure
R5656	T8977	T8976	prep	from,are
R5657	T8978	T8979	det	a,distribution
R5658	T8979	T8977	pobj	distribution,from
R5659	T8980	T8979	amod	normal,distribution
R5660	T8981	T8969	punct	", ",test
R5661	T8982	T8983	compound	F,test
R5662	T8983	T8969	appos	test,test
R5663	T8984	T8983	punct	-,test
R5664	T8985	T8983	acl	looking,test
R5665	T8986	T8985	prep	for,looking
R5666	T8987	T8988	det	a,samples
R5667	T8988	T8989	poss	samples,homoscedascity
R5668	T8989	T8986	pobj	homoscedascity,for
R5669	T8990	T8988	case	',samples
R5670	T8991	T8969	punct	", ",test
R5671	T8992	T8993	poss	Student,test
R5672	T8993	T8969	appos	test,test
R5673	T8994	T8992	case	's,Student
R5674	T8995	T8993	compound	T,test
R5675	T8996	T8993	punct	-,test
R5676	T8997	T8998	aux	to,judge
R5677	T8998	T8993	advcl	judge,test
R5678	T8999	T9000	mark	if,have
R5679	T9000	T8998	ccomp	have,judge
R5680	T9001	T9000	nsubj	samples,have
R5681	T9002	T9001	prep	of,samples
R5682	T9003	T9004	amod	different,groups
R5683	T9004	T9002	pobj	groups,of
R5684	T9005	T9006	det	a,value
R5685	T9006	T9000	dobj	value,have
R5686	T9007	T9006	amod	different,value
R5687	T9008	T9006	amod	mean,value
R5688	T9009	T9000	cc	and,have
R5689	T9010	T9000	conj	are,have
R5690	T9011	T9010	attr	parts,are
R5691	T9012	T9010	prep	from,are
R5692	T9013	T9014	amod	different,distributions
R5693	T9014	T9012	pobj	distributions,from
R5694	T9015	T9014	amod	normal,distributions
R5695	T9016	T8960	punct	.,performed
R5696	T9018	T9019	det	The,values
R5697	T9019	T9022	nsubjpass	values,indicated
R5698	T9020	T9019	amod	exact,values
R5699	T9021	T9019	compound	probability,values
R5700	T9023	T9019	cc	and,values
R5701	T9024	T9025	det	the,significance
R5702	T9025	T9019	conj	significance,values
R5703	T9026	T9025	prep	of,significance
R5704	T9027	T9028	det	an,analysis
R5705	T9028	T9026	pobj	analysis,of
R5706	T9029	T9022	auxpass	are,indicated
R5707	T9030	T9031	advmod	when,described
R5708	T9031	T9022	advcl	described,indicated
R5709	T9032	T9033	det	the,experiments
R5710	T9033	T9031	nsubjpass	experiments,described
R5711	T9034	T9031	auxpass	are,described
R5712	T9035	T9022	punct	.,indicated
R5713	T9090	T9089	prep	of,Expression
R5714	T9091	T9092	compound	annexin,A7
R5715	T9092	T9090	pobj	A7,of
R5716	T9093	T9089	prep	in,Expression
R5717	T9094	T9095	amod	human,cells
R5718	T9095	T9093	pobj	cells,in
R5719	T9096	T9095	amod	red,cells
R5720	T9097	T9095	compound	blood,cells
R5721	T9098	T9099	punct	(,1
R5722	T9099	T9095	parataxis	1,cells
R5723	T9100	T9099	punct	),1
R5724	T9101	T9095	cc	and,cells
R5725	T9102	T9103	amod	human,platelets
R5726	T9103	T9095	conj	platelets,cells
R5727	T9104	T9105	punct	(,2
R5728	T9105	T9103	parataxis	2,platelets
R5729	T9106	T9105	punct	),2
R5730	T9107	T9089	punct	.,Expression
R5731	T9109	T9110	compound	Protein,homogenates
R5732	T9110	T9111	nsubjpass	homogenates,separated
R5733	T9112	T9111	auxpass	were,separated
R5734	T9113	T9111	prep	by,separated
R5735	T9114	T9115	compound	SDS,PAGE
R5736	T9115	T9113	pobj	PAGE,by
R5737	T9116	T9115	punct	-,PAGE
R5738	T9117	T9118	punct	(,acrylamide
R5739	T9118	T9111	parataxis	acrylamide,separated
R5740	T9119	T9120	nummod	12,%
R5741	T9120	T9118	compound	%,acrylamide
R5742	T9121	T9118	punct	),acrylamide
R5743	T9122	T9111	punct	.,separated
R5744	T9124	T9125	det	The,blot
R5745	T9125	T9128	nsubjpass	blot,probed
R5746	T9126	T9125	amod	resulting,blot
R5747	T9127	T9125	amod	western,blot
R5748	T9128	T9130	ccomp	probed,was
R5749	T9129	T9128	auxpass	was,probed
R5750	T9131	T9128	prep	with,probed
R5751	T9132	T9131	pobj	mAb,with
R5752	T9133	T9132	nummod	203–217,mAb
R5753	T9134	T9130	punct	", ",was
R5754	T9135	T9130	nsubj	visualization,was
R5755	T9136	T9130	prep	by,was
R5756	T9137	T9138	det	a,antibody
R5757	T9138	T9136	pobj	antibody,by
R5758	T9139	T9138	amod	secondary,antibody
R5759	T9140	T9141	npadvmod	peroxidase,coupled
R5760	T9141	T9138	amod	coupled,antibody
R5761	T9142	T9138	acl	followed,antibody
R5762	T9143	T9142	agent	by,followed
R5763	T9144	T9143	pobj	ECL,by
R5764	T9145	T9130	punct	.,was
R5765	T9147	T9148	det	Both,isoforms
R5766	T9148	T9149	nsubjpass	isoforms,detected
R5767	T9149	T9151	ccomp	detected,is
R5768	T9150	T9149	auxpass	are,detected
R5769	T9152	T9149	prep	in,detected
R5770	T9153	T9154	amod	red,cells
R5771	T9154	T9152	pobj	cells,in
R5772	T9155	T9154	compound	blood,cells
R5773	T9156	T9151	punct	", ",is
R5774	T9157	T9151	prep	in,is
R5775	T9158	T9157	pobj	platelets,in
R5776	T9159	T9160	advmod	only,isoform
R5777	T9160	T9151	nsubj	isoform,is
R5778	T9161	T9160	det	the,isoform
R5779	T9162	T9160	amod	small,isoform
R5780	T9163	T9151	acomp	present,is
R5781	T9164	T9151	punct	.,is
R5782	T9241	T9240	prep	of,Enrichment
R5783	T9242	T9243	compound	annexin,A7
R5784	T9243	T9241	pobj	A7,of
R5785	T9244	T9243	cc	and,A7
R5786	T9245	T9243	conj	sorcin,A7
R5787	T9246	T9240	prep	in,Enrichment
R5788	T9247	T9246	pobj	exovesicles,in
R5789	T9248	T9247	acl	derived,exovesicles
R5790	T9249	T9248	prep	from,derived
R5791	T9250	T9251	amod	red,cells
R5792	T9251	T9249	pobj	cells,from
R5793	T9252	T9251	compound	blood,cells
R5794	T9253	T9240	punct	.,Enrichment
R5795	T9255	T9256	nsubjpass	Vesicles,generated
R5796	T9257	T9255	prep	from,Vesicles
R5797	T9258	T9259	amod	wild,type
R5798	T9259	T9257	pobj	type,from
R5799	T9260	T9259	punct	(,type
R5800	T9261	T9259	appos	wt,type
R5801	T9262	T9259	punct	),type
R5802	T9263	T9259	cc	and,type
R5803	T9264	T9265	nmod	anxA7,mutant
R5804	T9265	T9259	conj	mutant,type
R5805	T9266	T9264	punct	-,anxA7
R5806	T9267	T9264	punct	/,anxA7
R5807	T9268	T9264	punct	-,anxA7
R5808	T9269	T9265	punct	(,mutant
R5809	T9270	T9265	appos	ko,mutant
R5810	T9271	T9256	punct	),generated
R5811	T9272	T9256	auxpass	were,generated
R5812	T9273	T9256	prep	with,generated
R5813	T9274	T9275	compound	Ca2+,ionophore
R5814	T9275	T9277	compound	ionophore,treatment
R5815	T9276	T9275	punct	/,ionophore
R5816	T9277	T9273	pobj	treatment,with
R5817	T9278	T9256	punct	", ",generated
R5818	T9279	T9256	conj	isolated,generated
R5819	T9280	T9279	prep	by,isolated
R5820	T9281	T9282	amod	differential,centrifugation
R5821	T9282	T9280	pobj	centrifugation,by
R5822	T9283	T9279	cc	and,isolated
R5823	T9284	T9279	conj	analysed,isolated
R5824	T9285	T9284	prep	by,analysed
R5825	T9286	T9285	pobj	immunoblotting,by
R5826	T9287	T9284	prep	with,analysed
R5827	T9288	T9289	nmod	mAb,203
R5828	T9289	T9287	pobj	203,with
R5829	T9290	T9291	punct	–,217
R5830	T9291	T9289	prep	217,203
R5831	T9292	T9289	cc	and,203
R5832	T9293	T9294	det	a,antibody
R5833	T9294	T9289	conj	antibody,203
R5834	T9295	T9294	nmod	sorcin,antibody
R5835	T9296	T9294	amod	polyclonal,antibody
R5836	T9297	T9256	punct	.,generated
R5837	T9299	T9300	prep	In,are
R5838	T9301	T9299	amod	general,In
R5839	T9302	T9300	punct	", ",are
R5840	T9303	T9304	compound	annexin,A7
R5841	T9304	T9300	nsubj	A7,are
R5842	T9305	T9304	cc	and,A7
R5843	T9306	T9304	conj	sorcin,A7
R5844	T9307	T9308	advmod	more,abundant
R5845	T9308	T9300	acomp	abundant,are
R5846	T9309	T9300	prep	in,are
R5847	T9310	T9309	pobj	nanovesicles,in
R5848	T9311	T9300	punct	.,are
R5849	T9313	T9314	det	The,isoform
R5850	T9314	T9317	nsubjpass	isoform,observed
R5851	T9315	T9316	nummod	51,kDa
R5852	T9316	T9314	compound	kDa,isoform
R5853	T9318	T9314	prep	of,isoform
R5854	T9319	T9320	compound	annexin,A7
R5855	T9320	T9318	pobj	A7,of
R5856	T9321	T9322	punct	(,arrows
R5857	T9322	T9314	parataxis	arrows,isoform
R5858	T9323	T9322	punct	),arrows
R5859	T9324	T9317	auxpass	is,observed
R5860	T9325	T9317	advmod	only,observed
R5861	T9326	T9317	prep	in,observed
R5862	T9327	T9326	pobj	nanovesicles,in
R5863	T9328	T9317	punct	.,observed
R5864	T9330	T9331	nsubjpass	Samples,normalized
R5865	T9332	T9330	prep	of,Samples
R5866	T9333	T9334	det	both,types
R5867	T9334	T9332	pobj	types,of
R5868	T9335	T9334	compound	vesicles,types
R5869	T9336	T9331	auxpass	were,normalized
R5870	T9337	T9331	prep	according,normalized
R5871	T9338	T9337	prep	to,according
R5872	T9339	T9340	poss	their,activity
R5873	T9340	T9338	pobj	activity,to
R5874	T9341	T9342	compound	acetylcholine,esterase
R5875	T9342	T9340	compound	esterase,activity
R5876	T9343	T9331	punct	.,normalized
R5877	T9345	T9346	amod	Human,cells
R5878	T9346	T9349	nsubjpass	cells,used
R5879	T9347	T9346	amod	red,cells
R5880	T9348	T9346	compound	blood,cells
R5881	T9350	T9351	punct	(,co
R5882	T9351	T9346	parataxis	co,cells
R5883	T9352	T9351	punct	),co
R5884	T9353	T9349	auxpass	were,used
R5885	T9354	T9349	prep	for,used
R5886	T9355	T9354	pobj	control,for
R5887	T9356	T9349	cc	and,used
R5888	T9357	T9349	conj	normalized,used
R5889	T9358	T9357	advmod	independently,normalized
R5890	T9359	T9349	punct	.,used
R5891	T9398	T9397	prep	of,Association
R5892	T9399	T9400	compound	annexin,A7
R5893	T9400	T9398	pobj	A7,of
R5894	T9401	T9400	cc	and,A7
R5895	T9402	T9400	conj	sorcin,A7
R5896	T9403	T9397	prep	with,Association
R5897	T9404	T9405	amod	distinct,fractions
R5898	T9405	T9403	pobj	fractions,with
R5899	T9406	T9407	amod	red,cell
R5900	T9407	T9405	compound	cell,fractions
R5901	T9408	T9407	compound	blood,cell
R5902	T9409	T9410	compound	plasma,membrane
R5903	T9410	T9405	compound	membrane,fractions
R5904	T9411	T9397	punct	.,Association
R5905	T9413	T9414	amod	Lysed,cells
R5906	T9414	T9418	nsubjpass	cells,added
R5907	T9415	T9414	amod	human,cells
R5908	T9416	T9414	amod	red,cells
R5909	T9417	T9414	compound	blood,cells
R5910	T9419	T9418	auxpass	were,added
R5911	T9420	T9418	prep	to,added
R5912	T9421	T9422	det	a,gradient
R5913	T9422	T9420	pobj	gradient,to
R5914	T9423	T9424	npadvmod	self,forming
R5915	T9424	T9422	amod	forming,gradient
R5916	T9425	T9422	compound	iodixanol,gradient
R5917	T9426	T9422	compound	density,gradient
R5918	T9427	T9418	punct	.,added
R5919	T9429	T9430	det	The,density
R5920	T9430	T9431	nsubj	density,increases
R5921	T9432	T9430	prep	of,density
R5922	T9433	T9434	det	the,gradient
R5923	T9434	T9432	pobj	gradient,of
R5924	T9435	T9431	prep	from,increases
R5925	T9436	T9435	pobj	left,from
R5926	T9437	T9438	punct	(,g
R5927	T9438	T9436	parataxis	g,left
R5928	T9439	T9438	nummod	1.06,g
R5929	T9440	T9441	punct	/,ml
R5930	T9441	T9438	prep	ml,g
R5931	T9442	T9438	punct	),g
R5932	T9443	T9435	prep	to,from
R5933	T9444	T9443	pobj	right,to
R5934	T9445	T9446	punct	(,g
R5935	T9446	T9444	parataxis	g,right
R5936	T9447	T9446	nummod	1.20,g
R5937	T9448	T9449	punct	/,ml
R5938	T9449	T9446	prep	ml,g
R5939	T9450	T9446	punct	),g
R5940	T9451	T9431	punct	.,increases
R5941	T9453	T9454	nsubjpass	Fractions,analysed
R5942	T9455	T9454	auxpass	were,analysed
R5943	T9456	T9454	prep	by,analysed
R5944	T9457	T9456	pobj	immunoblotting,by
R5945	T9458	T9454	advcl	using,analysed
R5946	T9459	T9460	nmod	mAb,203
R5947	T9460	T9458	dobj	203,using
R5948	T9461	T9462	punct	–,217
R5949	T9462	T9460	prep	217,203
R5950	T9463	T9460	cc	and,203
R5951	T9464	T9465	det	the,antibody
R5952	T9465	T9460	conj	antibody,203
R5953	T9466	T9465	nmod	sorcin,antibody
R5954	T9467	T9465	amod	polyclonal,antibody
R5955	T9468	T9454	punct	.,analysed
R5959	T9493	T9494	amod	red,cells
R5960	T9494	T9492	pobj	cells,of
R5961	T9495	T9494	compound	blood,cells
R5962	T9496	T9494	prep	from,cells
R5963	T9497	T9498	nmod	anxA7,mutant
R5964	T9498	T9502	nmod	mutant,mice
R5965	T9499	T9497	punct	-,anxA7
R5966	T9500	T9497	punct	/,anxA7
R5967	T9501	T9497	punct	-,anxA7
R5968	T9502	T9496	pobj	mice,from
R5969	T9503	T9504	punct	(,B
R5970	T9504	T9498	parataxis	B,mutant
R5971	T9505	T9504	punct	),B
R5972	T9506	T9498	cc	and,mutant
R5973	T9507	T9508	amod	wild,type
R5974	T9508	T9498	conj	type,mutant
R5975	T9509	T9510	punct	(,A
R5976	T9510	T9502	parataxis	A,mice
R5977	T9511	T9510	punct	),A
R5978	T9512	T9491	punct	.,microscopy
R5979	T9514	T9515	det	The,diameters
R5980	T9515	T9518	nsubj	diameters,are
R5981	T9516	T9515	amod	mean,diameters
R5982	T9517	T9515	amod	cellular,diameters
R5983	T9519	T9520	nummod	6.0,μm
R5984	T9520	T9518	attr	μm,are
R5985	T9521	T9520	cc	and,μm
R5986	T9522	T9523	nummod	5.7,μm
R5987	T9523	T9520	conj	μm,μm
R5988	T9524	T9518	punct	", ",are
R5989	T9525	T9518	advmod	respectively,are
R5992	T9529	T9531	nsubj	differences,are
R5994	T9532	T9533	advmod	statistically,significant
R5995	T9533	T9531	acomp	significant,are
R5996	T9534	T9535	punct	(,40
R5997	T9535	T9531	parataxis	40,are
R5998	T9536	T9537	nsubj	p,0.015
R5999	T9537	T9535	ccomp	0.015,40
R6000	T9538	T9537	punct	=,0.015
R6001	T9539	T9535	punct	;,40
R6002	T9540	T9535	nsubj	n,40
R6003	T9541	T9535	punct	=,40
R6004	T9542	T9535	punct	),40
R6005	T9543	T9531	punct	.,are
R6006	T9545	T9546	dep	Bar,μm
R6007	T9547	T9546	punct	", ",μm
R6008	T9548	T9546	nummod	3,μm
R6009	T9549	T9546	punct	.,μm
R6014	T9617	T9618	amod	Osmotic,resistance
R6015	T9618	T9619	compound	resistance,curves
R6016	T9620	T9619	prep	of,curves
R6017	T9621	T9622	amod	red,cells
R6018	T9622	T9620	pobj	cells,of
R6019	T9623	T9622	compound	blood,cells
R6020	T9624	T9619	prep	from,curves
R6021	T9625	T9626	amod	wild,type
R6022	T9626	T9627	nmod	type,mice
R6023	T9627	T9624	pobj	mice,from
R6024	T9628	T9626	cc	and,type
R6025	T9629	T9626	conj	anxA7,type
R6026	T9630	T9629	punct	-,anxA7
R6027	T9631	T9629	punct	/,anxA7
R6028	T9632	T9629	punct	-,anxA7
R6029	T9633	T9627	amod	mutant,mice
R6030	T9634	T9619	punct	.,curves
R6031	T9636	T9637	det	The,resistance
R6032	T9637	T9639	nsubj	resistance,is
R6033	T9638	T9637	amod	osmotic,resistance
R6034	T9640	T9637	prep	towards,resistance
R6035	T9641	T9640	pobj	changes,towards
R6036	T9642	T9641	prep	in,changes
R6037	T9643	T9644	det	the,strength
R6038	T9644	T9642	pobj	strength,in
R6039	T9645	T9644	amod	extracellular,strength
R6040	T9646	T9644	amod	ionic,strength
R6041	T9647	T9648	det	a,assay
R6042	T9648	T9639	attr	assay,is
R6043	T9649	T9648	amod	convenient,assay
R6044	T9650	T9648	prep	for,assay
R6045	T9651	T9650	pobj	analysis,for
R6046	T9652	T9651	prep	of,analysis
R6047	T9653	T9654	det	the,integrity
R6048	T9654	T9652	pobj	integrity,of
R6049	T9655	T9656	amod	red,cell
R6050	T9656	T9654	compound	cell,integrity
R6051	T9657	T9656	compound	blood,cell
R6052	T9658	T9639	punct	.,is
R6053	T9660	T9661	nsubjpass	It,measured
R6054	T9662	T9661	auxpass	is,measured
R6055	T9663	T9661	prep	as,measured
R6056	T9664	T9665	det	a,concentration
R6057	T9665	T9663	pobj	concentration,as
R6058	T9666	T9667	compound	sodium,chloride
R6059	T9667	T9665	compound	chloride,concentration
R6060	T9668	T9669	prep	in,starts
R6061	T9669	T9665	relcl	starts,concentration
R6062	T9670	T9668	pobj	which,in
R6063	T9671	T9672	amod	cellular,lysis
R6064	T9672	T9669	nsubj	lysis,starts
R6065	T9673	T9674	punct	(,resistance
R6066	T9674	T9665	parataxis	resistance,concentration
R6067	T9675	T9674	amod	minimal,resistance
R6068	T9676	T9674	punct	),resistance
R6069	T9677	T9665	prep	up,concentration
R6070	T9678	T9677	prep	to,up
R6071	T9679	T9680	det	a,lysis
R6072	T9680	T9678	pobj	lysis,to
R6073	T9681	T9680	amod	complete,lysis
R6074	T9682	T9683	punct	(,resistance
R6075	T9683	T9680	parataxis	resistance,lysis
R6076	T9684	T9683	amod	maximal,resistance
R6077	T9685	T9683	punct	),resistance
R6078	T9686	T9680	prep	of,lysis
R6079	T9687	T9688	det	a,cell
R6080	T9688	T9686	pobj	cell,of
R6081	T9689	T9688	amod	red,cell
R6082	T9690	T9688	compound	blood,cell
R6083	T9691	T9661	punct	.,measured
R6084	T9693	T9694	det	The,resistance
R6085	T9694	T9696	nsubj	resistance,is
R6086	T9695	T9694	amod	osmotic,resistance
R6087	T9697	T9694	prep	of,resistance
R6088	T9698	T9699	compound	annexin,A7
R6089	T9699	T9700	npadvmod	A7,deficient
R6090	T9700	T9701	amod	deficient,cells
R6091	T9701	T9697	pobj	cells,of
R6092	T9702	T9701	amod	red,cells
R6093	T9703	T9701	compound	blood,cells
R6094	T9704	T9705	advmod	significantly,increased
R6095	T9705	T9696	acomp	increased,is
R6096	T9706	T9696	prep	compared,is
R6097	T9707	T9706	prep	to,compared
R6098	T9708	T9709	det	the,one
R6099	T9709	T9707	pobj	one,to
R6100	T9710	T9709	prep	of,one
R6101	T9711	T9712	amod	wild,type
R6102	T9712	T9710	pobj	type,of
R6103	T9713	T9714	punct	(,8
R6104	T9714	T9696	parataxis	8,is
R6105	T9715	T9716	nsubj	p,0.00066
R6106	T9716	T9714	ccomp	0.00066,8
R6107	T9717	T9716	punct	=,0.00066
R6108	T9718	T9714	punct	;,8
R6109	T9719	T9714	nsubj	n,8
R6110	T9720	T9714	punct	=,8
R6111	T9721	T9714	punct	),8
R6112	T9722	T9696	punct	.,is
R6113	T9783	T9784	compound	Platelet,aggregation
R6114	T9784	T9785	compound	aggregation,curves
R6115	T9786	T9785	prep	from,curves
R6116	T9787	T9788	npadvmod	platelet,rich
R6117	T9788	T9789	amod	rich,plasma
R6118	T9789	T9786	pobj	plasma,from
R6119	T9790	T9789	prep	of,plasma
R6120	T9791	T9792	nmod	annexin,A7
R6121	T9792	T9793	nmod	A7,mice
R6122	T9793	T9790	pobj	mice,of
R6123	T9794	T9795	compound	knock,out
R6124	T9795	T9792	appos	out,A7
R6125	T9796	T9795	cc	and,out
R6126	T9797	T9798	amod	wild,type
R6127	T9798	T9795	conj	type,out
R6128	T9799	T9785	punct	.,curves
R6129	T9801	T9802	det	The,values
R6130	T9802	T9804	nsubjpass	values,measured
R6131	T9803	T9802	compound	transmission,values
R6132	T9805	T9804	auxpass	were,measured
R6133	T9806	T9804	prep	with,measured
R6134	T9807	T9808	det	an,photometer
R6135	T9808	T9806	pobj	photometer,with
R6136	T9809	T9808	compound	APACT,photometer
R6137	T9810	T9804	cc	and,measured
R6138	T9811	T9812	nsubjpass	aggregation,initiated
R6139	T9812	T9804	conj	initiated,measured
R6140	T9813	T9812	auxpass	was,initiated
R6141	T9814	T9812	prep	by,initiated
R6142	T9815	T9814	pcomp	adding,by
R6143	T9816	T9815	dobj	ristocetin,adding
R6144	T9817	T9812	punct	.,initiated
R6145	T9819	T9820	det	The,seconds
R6146	T9820	T9823	nsubjpass	seconds,given
R6147	T9821	T9820	amod	first,seconds
R6148	T9822	T9820	nummod	thirty,seconds
R6149	T9824	T9823	auxpass	are,given
R6150	T9825	T9823	punct	.,given
R6151	T9827	T9828	amod	Constant,counts
R6152	T9828	T9830	nsubjpass	counts,used
R6153	T9829	T9828	compound	platelet,counts
R6154	T9831	T9830	auxpass	were,used
R6155	T9832	T9830	prep	throughout,used
R6156	T9833	T9834	det	all,experiments
R6157	T9834	T9832	pobj	experiments,throughout
R6158	T9835	T9830	punct	.,used
R6159	T9837	T9838	det	The,data
R6160	T9838	T9841	nsubjpass	data,analysed
R6161	T9839	T9840	compound	aggregation,curve
R6162	T9840	T9838	compound	curve,data
R6163	T9841	T9843	ccomp	analysed,set
R6164	T9842	T9841	auxpass	were,analysed
R6165	T9844	T9841	prep	for,analysed
R6166	T9845	T9846	compound	slope,values
R6167	T9846	T9844	pobj	values,for
R6168	T9847	T9843	punct	", ",set
R6169	T9848	T9849	det	the,amplitude
R6170	T9849	T9843	nsubjpass	amplitude,set
R6171	T9850	T9849	amod	maximal,amplitude
R6172	T9851	T9849	compound	aggregation,amplitude
R6173	T9852	T9849	prep	of,amplitude
R6174	T9853	T9854	det	every,curve
R6175	T9854	T9852	pobj	curve,of
R6176	T9855	T9854	amod	single,curve
R6177	T9856	T9843	auxpass	was,set
R6178	T9857	T9843	prep	to,set
R6179	T9858	T9859	nummod	100,%
R6180	T9859	T9857	pobj	%,to
R6181	T9860	T9843	punct	.,set
R6182	T9862	T9863	det	Both,curves
R6183	T9863	T9865	nsubj	curves,differ
R6184	T9864	T9863	amod	murine,curves
R6185	T9865	T9866	ccomp	differ,shows
R6186	T9867	T9865	advmod	significantly,differ
R6187	T9868	T9865	prep	at,differ
R6188	T9869	T9870	det	a,point
R6189	T9870	T9868	pobj	point,at
R6190	T9871	T9870	compound	time,point
R6191	T9872	T9870	prep	of,point
R6192	T9873	T9874	nummod	seven,seconds
R6193	T9874	T9872	pobj	seconds,of
R6194	T9875	T9874	prep	after,seconds
R6195	T9876	T9877	compound	platelet,initiation
R6196	T9877	T9875	pobj	initiation,after
R6197	T9878	T9866	punct	", ",shows
R6198	T9879	T9880	det	the,mutant
R6199	T9880	T9866	nsubj	mutant,shows
R6200	T9881	T9882	det	a,velocity
R6201	T9882	T9866	dobj	velocity,shows
R6202	T9883	T9884	advmod	slightly,lower
R6203	T9884	T9882	amod	lower,velocity
R6204	T9885	T9882	compound	aggregation,velocity
R6205	T9886	T9887	punct	(,transmission
R6206	T9887	T9882	parataxis	transmission,velocity
R6207	T9888	T9889	nsubj	p,0.0287
R6208	T9889	T9887	ccomp	0.0287,transmission
R6209	T9890	T9889	punct	=,0.0287
R6210	T9891	T9887	punct	", ",transmission
R6211	T9892	T9893	compound	n,out
R6212	T9893	T9895	nsubj	out,16
R6213	T9894	T9893	compound	knock,out
R6214	T9895	T9887	ccomp	16,transmission
R6215	T9896	T9895	punct	=,16
R6216	T9897	T9887	punct	", ",transmission
R6217	T9898	T9899	nmod	n,type
R6218	T9899	T9901	nsubj	type,15
R6219	T9900	T9899	amod	wild,type
R6220	T9901	T9887	ccomp	15,transmission
R6221	T9902	T9901	punct	=,15
R6222	T9903	T9887	punct	", ",transmission
R6223	T9904	T9905	amod	mean,out
R6224	T9905	T9907	nsubj	out,transmission
R6225	T9906	T9905	compound	knock,out
R6226	T9907	T9887	ccomp	transmission,transmission
R6227	T9908	T9907	punct	=,transmission
R6228	T9909	T9910	nummod	67.7,%
R6229	T9910	T9907	compound	%,transmission
R6230	T9911	T9887	punct	", ",transmission
R6231	T9912	T9913	amod	mean,type
R6232	T9913	T9915	nsubj	type,transmission
R6233	T9914	T9913	amod	wild,type
R6234	T9915	T9887	ccomp	transmission,transmission
R6235	T9916	T9915	punct	=,transmission
R6236	T9917	T9918	nummod	77.1,%
R6237	T9918	T9915	compound	%,transmission
R6238	T9919	T9887	punct	", ",transmission
R6239	T9920	T9921	amod	standard,error
R6240	T9921	T9922	compound	error,out
R6241	T9922	T9924	nsubj	out,transmission
R6242	T9923	T9922	compound	knock,out
R6243	T9924	T9887	ccomp	transmission,transmission
R6244	T9925	T9924	punct	=,transmission
R6245	T9926	T9927	nummod	8.3,%
R6246	T9927	T9924	compound	%,transmission
R6247	T9928	T9887	punct	", ",transmission
R6248	T9929	T9930	amod	standard,error
R6249	T9930	T9931	nmod	error,type
R6250	T9931	T9887	nsubj	type,transmission
R6251	T9932	T9931	amod	wild,type
R6252	T9933	T9887	punct	=,transmission
R6253	T9934	T9935	nummod	13.8,%
R6254	T9935	T9887	compound	%,transmission
R6255	T9936	T9887	punct	),transmission
R6256	T9937	T9866	punct	.,shows
R6257	T9939	T9940	amod	Murine,platelets
R6258	T9940	T9941	nsubj	platelets,react
R6259	T9942	T9941	advmod	immediately,react
R6260	T9943	T9941	prep	to,react
R6261	T9944	T9945	det	the,chemical
R6262	T9945	T9943	pobj	chemical,to
R6263	T9946	T9945	amod	initiating,chemical
R6264	T9947	T9941	cc	and,react
R6265	T9948	T9941	conj	show,react
R6266	T9949	T9950	det	no,phase
R6267	T9950	T9948	dobj	phase,show
R6268	T9951	T9950	compound	lag,phase
R6269	T9952	T9948	prep	like,show
R6270	T9953	T9954	det	the,platelets
R6271	T9954	T9952	pobj	platelets,like
R6272	T9955	T9954	amod	normal,platelets
R6273	T9956	T9954	amod	human,platelets
R6274	T9957	T9941	punct	.,react
R6275	T9959	T9960	prep	For,shown
R6276	T9961	T9959	pobj	comparison,For
R6277	T9962	T9961	prep	of,comparison
R6278	T9963	T9964	det	the,range
R6279	T9964	T9962	pobj	range,of
R6280	T9965	T9964	prep	of,range
R6281	T9966	T9967	det	the,impairment
R6282	T9967	T9965	pobj	impairment,of
R6283	T9968	T9967	compound	platelet,impairment
R6284	T9969	T9970	advmod	slightly,affected
R6285	T9970	T9971	amod	affected,platelets
R6286	T9971	T9960	nsubjpass	platelets,shown
R6287	T9972	T9971	amod	human,platelets
R6288	T9973	T9960	auxpass	are,shown
R6289	T9974	T9975	advmod	as,well
R6290	T9975	T9960	advmod	well,shown
R6291	T9976	T9977	punct	(,syndrome
R6292	T9977	T9960	parataxis	syndrome,shown
R6293	T9978	T9979	compound	von,Willebrand
R6294	T9979	T9977	compound	Willebrand,syndrome
R6295	T9980	T9977	punct	),syndrome
R6296	T9981	T9960	punct	.,shown
R1408	T2601	T2599	pobj	suggestion,to
R1409	T2602	T2601	punct	", ",suggestion
R1410	T2603	T2604	mark	that,plays
R1411	T2604	T2601	acl	plays,suggestion
R1412	T2605	T2604	punct	", ",plays
R1413	T2606	T2604	prep	along,plays
R1414	T2607	T2606	prep	with,along
R1415	T2608	T2609	compound	raft,domains
R1416	T2609	T2607	pobj	domains,with
R1417	T2610	T2604	punct	", ",plays
R1418	T2611	T2612	compound	annexin,A7
R1419	T2612	T2604	nsubj	A7,plays
R1582	T2787	T2773	prep	for,both
R1583	T2788	T2787	pobj	wt,for
R1584	T2789	T2788	cc	and,wt
R1585	T2790	T2788	conj	ko,wt
R1586	T2791	T2773	punct	),both
R1587	T2792	T2748	punct	.,differ
R1588	T2794	T2795	nsubj	It,appears
R1589	T2796	T2797	mark	that,is
R1590	T2797	T2795	ccomp	is,appears
R1591	T2798	T2799	compound	annexin,A7
R1592	T2799	T2797	nsubj	A7,is
R1593	T2800	T2797	punct	", ",is
R1594	T2801	T2802	mark	although,described
R1595	T2802	T2797	advcl	described,is
R1649	T2859	T2860	aux	To,study
R1650	T2860	T2861	advcl	study,used
R1651	T2862	T2863	det	the,distribution
R1652	T2863	T2860	dobj	distribution,study
R1653	T2864	T2863	prep	of,distribution
R1654	T2865	T2866	compound	annexin,A7
R1655	T2866	T2864	pobj	A7,of
R1656	T2867	T2860	prep	in,study
R1657	T2868	T2869	amod	red,cells
R1658	T2869	T2867	pobj	cells,in
R1659	T2870	T2869	compound	blood,cells
R1660	T2871	T2861	nsubj	we,used
R1661	T2872	T2873	npadvmod	self,forming
R1662	T2873	T2874	amod	forming,gradients
R1663	T2874	T2861	dobj	gradients,used
R1881	T3373	T3371	dobj	diameter,had
R1882	T3374	T3375	advmod	statistically,significant
R1883	T3375	T3373	amod	significant,diameter
R1884	T3376	T3373	amod	larger,diameter
R1885	T3377	T3373	compound	cell,diameter
R1886	T3378	T3373	prep	of,diameter
R1887	T3379	T3380	nummod	6.0,μm
R1888	T3380	T3378	pobj	μm,of
R1889	T3381	T3373	prep	compared,diameter
R1890	T3382	T3381	prep	to,compared
R1891	T3383	T3384	amod	wild,type
R1892	T3384	T3382	pobj	type,to
R1893	T3385	T3384	prep	with,type
R1894	T3386	T3387	nummod	5.7,μm
R1895	T3387	T3385	pobj	μm,with
R1896	T3388	T3389	punct	(,40
R5956	T9489	T9490	amod	Dark,field
R5957	T9490	T9491	compound	field,microscopy
R5958	T9492	T9491	prep	of,microscopy
R5990	T9526	T9518	punct	.,are
R5991	T9528	T9529	det	The,differences
R5993	T9530	T9529	compound	size,differences
R1328	T2512	T2513	det	these,findings
R1329	T2513	T2509	dobj	findings,extended
R1330	T2514	T2509	cc	and,extended
R1331	T2515	T2509	conj	show,extended
R1332	T2516	T2515	advmod	here,show
R1333	T2517	T2518	mark	that,is
R1334	T2518	T2515	ccomp	is,show
R1402	T2594	T2595	poss	Its,presence
R1403	T2595	T2596	nsubj	presence,led
R1404	T2597	T2595	prep	in,presence
R1405	T2598	T2597	pobj	vesicles,in
R1406	T2599	T2596	prep	to,led
R1407	T2600	T2601	det	the,suggestion
R1897	T3389	T3373	parataxis	40,diameter
R1898	T3390	T3391	nsubj	p,0.015
R1899	T3391	T3389	ccomp	0.015,40
R1900	T3392	T3391	punct	=,0.015
R1901	T3393	T3389	punct	", ",40
R1941	T3437	T3438	nsubj	Shape,influence
R1942	T3439	T3437	cc	and,Shape
R1943	T3440	T3437	conj	MCV,Shape
R1944	T3441	T3437	prep	of,Shape
R1945	T3442	T3443	det	a,cell
R1946	T3443	T3441	pobj	cell,of
R1947	T3444	T3443	amod	red,cell
R1948	T3445	T3443	compound	blood,cell
R1949	T3446	T3438	advmod	essentially,influence
R1950	T3447	T3448	poss	its,function
R1951	T3448	T3438	dobj	function,influence
R1952	T3449	T3448	cc	and,function
R1953	T3450	T3451	amod	capillary,passage
R1954	T3451	T3448	conj	passage,function
R1955	T3452	T3438	punct	.,influence
R1956	T3454	T3455	det	The,form
R1957	T3455	T3458	nsubj	form,depends
R1958	T3456	T3455	amod	typical,form
R1959	T3457	T3455	compound	biconcave,form
R1960	T3459	T3458	prep	on,depends
R1961	T3460	T3461	amod	various,influences
R1962	T3461	T3459	pobj	influences,on
R1963	T3462	T3461	prep	including,influences
R1964	T3463	T3464	det	the,composition
R1965	T3464	T3462	pobj	composition,including
R1966	T3465	T3466	compound	membrane,lipid
R1967	T3466	T3464	compound	lipid,composition
R1968	T3467	T3464	cc	and,composition
R1969	T3468	T3469	det	the,cytoskeleton
R1970	T3469	T3464	conj	cytoskeleton,composition
R1971	T3470	T3469	amod	submembranous,cytoskeleton
R1972	T3471	T3472	punct	[,32
R1973	T3472	T3469	parataxis	32,cytoskeleton
R1974	T3473	T3472	punct	],32
R2231	T3752	T3753	poss	their,morphology
R2232	T3753	T3751	pobj	morphology,with
R2233	T3754	T3738	punct	.,tried
R2234	T3756	T3757	nsubj	We,observe
R2235	T3758	T3757	aux	could,observe
R2236	T3759	T3757	neg	not,observe
R2237	T3760	T3761	det	any,difference
R2238	T3761	T3757	dobj	difference,observe
R2239	T3762	T3763	advmod	statistically,significant
R2240	T3763	T3761	amod	significant,difference
R2241	T3764	T3761	prep	of,difference
R2242	T3765	T3764	pobj	values,of
R2243	T3766	T3765	acl	describing,values
R2244	T3767	T3768	compound	membrane,rigidity
R2245	T3768	T3766	dobj	rigidity,describing
R2246	T3769	T3768	cc	and,rigidity
R2247	T3770	T3771	compound	lysis,force
R2248	T3771	T3768	conj	force,rigidity
R2249	T3772	T3757	prep	in,observe
R1215	T2129	T2128	compound	lipid,rafts
R3918	T6487	T6488	det	the,absence

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T726	11-21	PR:000004080	denotes	Annexin A7
T728	37-49	CHEBI:16247	denotes	phospholipid
T729	128-147	GO:0042583	denotes	chromaffin granules
T730	152-161	_FRAGMENT	denotes	fusion of
T731	175-184	GO:0061025	denotes	membranes
T732	162-174	CHEBI:16247	denotes	phospholipid
T733	175-184	GO:0016020	denotes	membranes
T734	204-208	CHEBI:29108	denotes	Ca2+
T735	247-257	PR:000004080	denotes	annexin A7
T736	279-289	GO:0006887	denotes	exocytotic
T737	303-317	CHEBI:33567	denotes	catecholamines
T738	471-477	SO:0000417	denotes	domain
T739	494-500	SO:0000417	denotes	domain
T740	524-528	CHEBI:29108	denotes	Ca2+
T741	534-546	CHEBI:16247	denotes	phospholipid
T742	571-577	SO:0000417	denotes	domain
T743	639-671	CHEBI:62643	denotes	negatively charged phospholipids
T744	701-710	CHEBI:29108	denotes	Ca2+ ions
T745	712-722	PR:000004080	denotes	Annexin A7
T746	839-859	GO:0000380	denotes	Alternative splicing
T747	878-886	SO:0001060	denotes	isoforms
T748	910-918	SO:0001060	denotes	isoforms
T749	952-956	SO:0000147	denotes	exon
T750	1002-1008	SO:0000417	denotes	domain
T751	1015-1022	UBERON:0000479	denotes	tissues
T752	1046-1053	SO:0001060	denotes	isoform
T753	1079-1084	UBERON:0000955	denotes	brain
T754	1089-1094	UBERON:0000948	denotes	heart
T755	1112-1119	SO:0001060	denotes	isoform
T756	1135-1144	GO:0010467	denotes	expressed
T757	1155-1163	UBERON:0004288	denotes	skeletal
T758	1194-1204	PR:000004080	denotes	annexin A7
T759	1228-1235	GO:0005829	denotes	cytosol
T760	1244-1259	GO:0005886	denotes	plasma membrane
T761	1272-1279	GO:0005634	denotes	nucleus
T762	1284-1293	GO:0031982	denotes	vesicular
T763	1315-1322	UBERON:0002369	denotes	adrenal
T764	1323-1342	GO:0042583	denotes	chromaffin granules
T765	1355-1363	GO:0030315	denotes	t-tubule
T766	1378-1388	PR:000004080	denotes	Annexin A7
T767	1405-1414	GO:0016020	denotes	membranes
T768	1420-1424	CHEBI:29108	denotes	Ca2+
T769	1453-1466	GO:0005622	denotes	intracellular
T770	1467-1471	CHEBI:29108	denotes	Ca2+
T771	1519-1525	_FRAGMENT	denotes	plasma
T772	1542-1550	GO:0005886	denotes	membrane
T773	1534-1550	GO:0031965	denotes	nuclear membrane
T774	1565-1578	GO:0005622	denotes	intracellular
T775	1579-1587	GO:0031982	denotes	vesicles
T776	1602-1612	PR:000004080	denotes	annexin A7
T777	1629-1634	CHEBI:18059	denotes	lipid
T778	1629-1640	GO:0045121	denotes	lipid rafts
T779	1646-1651	CHEBI:18059	denotes	Lipid
T780	1646-1657	GO:0045121	denotes	Lipid rafts
T781	1677-1685	GO:0016020	denotes	membrane
T782	1677-1693	GO:0006900	denotes	membrane budding
T783	1701-1713	GO:0006900	denotes	vesiculation
T785	1785-1795	PR:000004080	denotes	annexin A7
T786	1818-1824	PR:000015619	denotes	sorcin
T787	1829-1839	PR:000009771	denotes	galectin-3
T788	1849-1855	PR:000015619	denotes	Sorcin
T789	1861-1865	CHEBI:29108	denotes	Ca2+
T790	1941-1951	PR:000004080	denotes	annexin A7
T791	1964-1973	GO:0016020	denotes	membranes
T792	1979-1983	CHEBI:29108	denotes	Ca2+
T793	2002-2008	PR:000015619	denotes	Sorcin
T794	2063-2072	CHEBI:8925	denotes	ryanodine
T795	2098-2106	GO:0065007	denotes	modulate
T796	2147-2153	PR:000015619	denotes	sorcin
T797	2154-2164	PR:000004080	denotes	annexin A7
T798	2184-2193	CHEBI:8925	denotes	ryanodine
T799	2215-2221	PR:000015619	denotes	Sorcin
T800	2226-2236	PR:000004080	denotes	annexin A7
T801	2243-2252	GO:0010467	denotes	expressed
T802	2260-2267	UBERON:0000479	denotes	tissues
T803	2305-2315	PR:000004080	denotes	annexin A7
T804	2320-2326	PR:000015619	denotes	sorcin
T805	2330-2334	CHEBI:29108	denotes	Ca2+
T806	2370-2374	CHEBI:29108	denotes	Ca2+
T807	2395-2408	SO:0000409	denotes	binding sites
T808	2475-2481	PR:000015619	denotes	sorcin
T809	2529-2539	PR:000004080	denotes	annexin A7
T810	2601-2607	PR:000015619	denotes	sorcin
T811	2608-2617	CHEBI:36357	denotes	molecules
T812	2622-2632	PR:000004080	denotes	annexin A7
T813	2633-2641	CHEBI:36357	denotes	molecule
T814	2648-2658	PR:000009771	denotes	Galectin-3
T815	2743-2762	GO:0005615	denotes	extracellular space
T816	2771-2778	GO:0005634	denotes	nucleus
T817	2783-2792	GO:0005737	denotes	cytoplasm
T818	2800-2812	GO:0005739	denotes	mitochondria
T819	2814-2825	GO:0005737	denotes	Cytoplasmic
T820	2826-2836	PR:000009771	denotes	galectin-3
T821	2884-2897	GO:0005739	denotes	mitochondrial
T822	2928-2938	PR:000004080	denotes	annexin A7
T823	2948-2958	PR:000009771	denotes	galectin-3
T824	2980-3000	GO:0005640	denotes	perinuclear membrane
T825	3015-3025	PR:000009771	denotes	galectin-3
T826	3041-3051	PR:000004080	denotes	annexin A7
T827	3063-3073	PR:000009771	denotes	galectin-3
T828	3087-3107	GO:0042981	denotes	apoptosis regulation
T829	3113-3126	GO:0005739	denotes	mitochondrial
T830	3177-3187	PR:000004080	denotes	annexin A7
T831	3229-3237	GO:0065007	denotes	regulate
T832	3252-3268	GO:0044425	denotes	membrane domains
T833	3291-3295	CHEBI:29108	denotes	Ca2+
T834	3296-3307	GO:0042592	denotes	homeostasis
T835	3312-3316	CHEBI:29108	denotes	Ca2+
T836	3312-3345	GO:0019722	denotes	Ca2+-dependent signaling pathways
T837	3411-3421	PR:000004080	denotes	annexin A7
T838	3432-3437	NCBITaxon:10088	denotes	mouse
T839	3451-3461	PR:000004080	denotes	annexin A7
T840	3473-3477	NCBITaxon:10088	denotes	mice
T841	3601-3605	NCBITaxon:10088	denotes	mice
T842	3617-3624	PR:000045358	denotes	insulin
T843	3742-3749	PR:000045358	denotes	insulin
T844	3814-3828	CL:0000746	denotes	cardiomyocytes
T845	3916-3931	CL:0000232	denotes	red blood cells
T846	3920-3925	UBERON:0000178	denotes	blood
T847	3936-3945	CL:0000233	denotes	platelets
T848	3953-3958	PR:000004080	denotes	anxA7
T849	3981-3996	CL:0000232	denotes	red blood cells
T850	3985-3990	UBERON:0000178	denotes	blood
T851	4001-4010	CL:0000233	denotes	platelets
T852	4039-4049	PR:000004080	denotes	annexin A7
T853	4079-4086	SO:0001060	denotes	isoform
T854	4121-4136	CL:0000232	denotes	red blood cells
T855	4125-4130	UBERON:0000178	denotes	blood
T856	4142-4157	CL:0000232	denotes	Red blood cells
T857	4146-4151	UBERON:0000178	denotes	blood
T859	4282-4292	_FRAGMENT	denotes	release of
T860	4315-4326	GO:0006887	denotes	exovesicles
T861	4315-4326	GO:0070382	denotes	exovesicles
T862	4437-4451	CL:0000232	denotes	red blood cell
T863	4441-4446	UBERON:0000178	denotes	blood
T864	4508-4523	CL:0000232	denotes	Red blood cells
T865	4512-4517	UBERON:0000178	denotes	blood
T866	4550-4560	GO:0006900	denotes	vesiculate
T867	4582-4596	CL:0000232	denotes	red blood cell
T868	4586-4591	UBERON:0000178	denotes	blood
T869	4592-4608	GO:0008219	denotes	cell destruction
T870	4660-4668	GO:0031982	denotes	vesicles
T871	4670-4676	_FRAGMENT	denotes	micro-
T872	4685-4693	GO:1990742	denotes	vesicles
T873	4762-4773	CHEBI:16113	denotes	cholesterol
T874	4778-4790	CHEBI:26739	denotes	sphingolipid
T875	4796-4801	CHEBI:18059	denotes	lipid
T876	4796-4814	GO:0045121	denotes	lipid raft domains
T877	4876-4888	GO:0009986	denotes	cell surface
T878	4939-4944	CHEBI:18059	denotes	lipid
T879	4939-4949	GO:0045121	denotes	lipid raft
T880	4959-4967	PR:000015763	denotes	stomatin
T881	5001-5013	GO:0005856	denotes	cytoskeletal
T882	5053-5059	PR:000015619	denotes	sorcin
T883	5064-5074	PR:000004080	denotes	annexin A7
T884	5091-5096	CHEBI:18059	denotes	lipid
T885	5091-5102	GO:0045121	denotes	lipid rafts
T886	5143-5151	GO:0031982	denotes	vesicles
T887	5157-5164	GO:0031982	denotes	vesicle
T888	5157-5174	GO:0006900	denotes	vesicle formation
T889	5220-5234	CL:0000232	denotes	red blood cell
T890	5224-5229	UBERON:0000178	denotes	blood
T891	5240-5252	GO:0005856	denotes	cytoskeletal
T892	5287-5299	CHEBI:16247	denotes	phospholipid
T893	5319-5336	GO:0005886	denotes	cellular membrane
T2247	5348-5358	PR:000004080	denotes	Annexin A7
T2248	5359-5369	GO:0010467	denotes	expression
T2249	5373-5388	CL:0000232	denotes	red blood cells
T2250	5377-5382	UBERON:0000178	denotes	blood
T2251	5390-5404	CL:0000232	denotes	red blood cell
T2252	5394-5399	UBERON:0000178	denotes	blood
T2253	5413-5424	GO:0070382	denotes	exovesicles
T2254	5432-5441	CL:0000233	denotes	platelets
T2255	5501-5508	SO:0001060	denotes	isoform
T2256	5512-5522	PR:000004080	denotes	annexin A7
T2257	5539-5545	PR:000015619	denotes	sorcin
T2258	5549-5555	_FRAGMENT	denotes	micro-
T2259	5564-5572	GO:1990742	denotes	vesicles
T2260	5586-5601	CL:0000232	denotes	red blood cells
T2261	5590-5595	UBERON:0000178	denotes	blood
T2262	5663-5677	GO:0045121	denotes	membrane rafts
T2263	5749-5756	SO:0001060	denotes	isoform
T2264	5797-5802	NCBITaxon:9606	denotes	human
T2265	5803-5818	CL:0000232	denotes	red blood cells
T2266	5807-5812	UBERON:0000178	denotes	blood
T2267	5837-5845	SO:0001060	denotes	isoforms
T2269	5965-5975	PR:000004080	denotes	annexin A7
T2270	6046-6053	SO:0001060	denotes	isoform
T2271	6490-6498	GO:0031982	denotes	vesicles
T2272	6539-6551	GO:0045121	denotes	raft domains
T2273	6553-6563	PR:000004080	denotes	annexin A7
T2274	6580-6588	GO:0016020	denotes	membrane
T2275	6610-6622	GO:0006900	denotes	vesiculation
T2276	6676-6691	CL:0000232	denotes	red blood cells
T2277	6680-6685	UBERON:0000178	denotes	blood
T2278	6709-6719	PR:000004080	denotes	annexin A7
T2279	6730-6734	NCBITaxon:10088	denotes	mice
T2280	6736-6741	PR:000004080	denotes	anxA7
T2282	6890-6895	NCBITaxon:9606	denotes	human
T2283	6896-6901	UBERON:0000178	denotes	blood
T2286	6972-6978	_FRAGMENT	denotes	micro-
T2287	6987-6995	GO:1990742	denotes	vesicles
T2288	7017-7021	CHEBI:29108	denotes	Ca2+
T2289	7022-7031	CHEBI:24869	denotes	ionophore
T2290	7059-7072	CHEBI:15355	denotes	acetylcholine
T2291	7120-7130	PR:000004080	denotes	Annexin A7
T2292	7150-7157	GO:0031982	denotes	vesicle
T2293	7197-7205	GO:0031982	denotes	vesicles
T2294	7227-7234	SO:0001060	denotes	isoform
T2295	7261-7269	GO:0031982	denotes	vesicles
T2296	7292-7299	GO:0031982	denotes	vesicle
T2297	7353-7367	CL:0000232	denotes	red blood cell
T2298	7357-7362	UBERON:0000178	denotes	blood
T2299	7368-7376	GO:0031982	denotes	vesicles
T2300	7420-7428	GO:0031982	denotes	vesicles
T2301	7442-7455	GO:1990742	denotes	microvesicles
T2302	7501-7511	PR:000004080	denotes	annexin A7
T2303	7552-7561	GO:0016020	denotes	membranes
T2304	7621-7635	CL:0000232	denotes	red blood cell
T2305	7625-7630	UBERON:0000178	denotes	blood
T2306	7636-7647	GO:0070382	denotes	exovesicles
T2307	7684-7690	PR:000015619	denotes	sorcin
T2308	7715-7723	GO:0031982	denotes	vesicles
T2309	7742-7748	PR:000015619	denotes	sorcin
T2310	7787-7795	GO:0031982	denotes	vesicles
T2311	8471-8481	PR:000004080	denotes	annexin A7
T2312	8485-8500	CL:0000232	denotes	red blood cells
T2313	8489-8494	UBERON:0000178	denotes	blood
T2314	8522-8531	CHEBI:31705	denotes	iodixanol
T2315	8556-8564	SO:0001060	denotes	isoforms
T2316	8684-8693	GO:0016020	denotes	membranes
T2317	8701-8710	GO:0016020	denotes	membranes
T2318	8727-8743	GO:0005886	denotes	plasma membranes
T2319	8747-8762	CL:0000232	denotes	red blood cells
T2320	8751-8756	UBERON:0000178	denotes	blood
T2321	8779-8789	GO:0043226	denotes	organelles
T2322	8895-8905	PR:000004080	denotes	annexin A7
T2323	8909-8928	GO:0044425	denotes	membrane subdomains
T2324	8949-8954	CHEBI:18059	denotes	lipid
T2325	8958-8963	CHEBI:18059	denotes	lipid
T2326	9029-9035	PR:000015619	denotes	sorcin
T2327	9126-9134	GO:0031982	denotes	vesicles
T2328	9165-9175	PR:000004080	denotes	annexin A7
T2329	9201-9210	CL:0000233	denotes	platelets
T2330	9215-9225	PR:000004080	denotes	annexin A7
T2331	9226-9236	GO:0010467	denotes	expression
T2332	9261-9268	SO:0001060	denotes	isoform
T3103	9658-9668	PR:000004080	denotes	annexin A7
T3104	9677-9691	CL:0000232	denotes	red blood cell
T3105	9681-9686	UBERON:0000178	denotes	blood
T3106	9729-9739	PR:000004080	denotes	annexin A7
T3107	9758-9772	CL:0000232	denotes	red blood cell
T3108	9762-9767	UBERON:0000178	denotes	blood
T3109	9773-9781	GO:0031982	denotes	vesicles
T3110	9844-9849	PR:000004080	denotes	anxA7
T3111	9852-9857	NCBITaxon:10088	denotes	mouse
T3112	9862-9876	CL:0000232	denotes	red blood cell
T3113	9866-9871	UBERON:0000178	denotes	blood
T3114	9927-9932	UBERON:0000178	denotes	blood
T3115	10060-10065	PR:000004080	denotes	anxA7
T3116	10068-10083	CL:0000232	denotes	red blood cells
T3117	10072-10077	UBERON:0000178	denotes	blood
T3118	10661-10675	CL:0000232	denotes	red blood cell
T3119	10665-10670	UBERON:0000178	denotes	blood
T3120	10715-10724	UBERON:0001982	denotes	capillary
T3121	10805-10813	GO:0016020	denotes	membrane
T3122	10814-10819	CHEBI:18059	denotes	lipid
T3123	10843-10853	GO:0016020	denotes	membranous
T3124	10854-10866	GO:0005856	denotes	cytoskeleton
T3125	10878-10888	PR:000004080	denotes	annexin A7
T3126	10979-10992	GO:0005576	denotes	extracellular
T3127	10993-10998	CHEBI:24870	denotes	ionic
T3128	11051-11065	CL:0000232	denotes	red blood cell
T3129	11055-11060	UBERON:0000178	denotes	blood
T3130	11099-11114	CHEBI:26710	denotes	sodium chloride
T3131	11138-11152	GO:0019835	denotes	cellular lysis
T3132	11198-11203	_FRAGMENT	denotes	lysis
T3133	11225-11227	_FRAGMENT	denotes	of
T3134	11232-11237	GO:0019835	denotes	cells
T3135	11297-11304	GO:0009986	denotes	surface
T3136	11333-11352	GO:0044237	denotes	cellular metabolism
T3137	11369-11382	GO:0005622	denotes	intracellular
T3138	11383-11386	CHEBI:24870	denotes	ion
T3139	11400-11415	CL:0000232	denotes	red blood cells
T3140	11404-11409	UBERON:0000178	denotes	blood
T3141	11508-11523	CL:0000232	denotes	red blood cells
T3142	11512-11517	UBERON:0000178	denotes	blood
T3143	11537-11545	GO:0016020	denotes	membrane
T3144	11586-11596	PR:000004080	denotes	annexin A7
T3145	11607-11622	CL:0000232	denotes	red blood cells
T3146	11611-11616	UBERON:0000178	denotes	blood
T3147	11751-11755	CHEBI:26710	denotes	NaCl
T3148	11756-11764	CHEBI:75958	denotes	solution
T3149	11839-11843	CHEBI:26710	denotes	NaCl
T3150	11844-11852	CHEBI:75958	denotes	solution
T3151	11882-11886	CHEBI:26710	denotes	NaCl
T3152	12038-12042	CHEBI:26710	denotes	NaCl
T3153	12043-12051	CHEBI:75958	denotes	solution
T3154	12099-12113	CL:0000232	denotes	red blood cell
T3155	12103-12108	UBERON:0000178	denotes	blood
T3156	12109-12122	GO:0005886	denotes	cell membrane
T3157	12181-12191	PR:000004080	denotes	annexin A7
T3158	12199-12207	GO:0016020	denotes	membrane
T3159	12305-12320	CL:0000232	denotes	red blood cells
T3160	12309-12314	UBERON:0000178	denotes	blood
T3161	12427-12435	GO:0016020	denotes	membrane
T3162	12449-12454	GO:0019835	denotes	lysis
T3163	12694-12709	CL:0000232	denotes	red blood cells
T3164	12698-12703	UBERON:0000178	denotes	blood
T3165	13286-13296	PR:000004080	denotes	annexin A7
T3166	13325-13340	CL:0000232	denotes	red blood cells
T3167	13329-13334	UBERON:0000178	denotes	blood
T3168	13406-13416	PR:000004080	denotes	annexin A7
T3169	13420-13427	GO:0031941	denotes	F-actin
T3170	13488-13496	GO:0016020	denotes	membrane
T3171	13530-13533	CHEBI:24870	denotes	ion
T3172	13530-13545	GO:0050801	denotes	ion homeostasis
T3948	13560-13570	PR:000004080	denotes	annexin A7
T3949	13587-13598	GO:0007599	denotes	haemostasis
T3950	13750-13756	NCBITaxon:39107	denotes	murine
T3952	13783-13793	CL:0000738	denotes	leukocytes
T3953	13795-13810	CL:0000232	denotes	red blood cells
T3954	13799-13804	UBERON:0000178	denotes	blood
T3955	13936-13945	CL:0000233	denotes	platelets
T3956	13947-13959	CL:0000775	denotes	neutrophiles
T3957	13961-13972	CL:0000542	denotes	lymphocytes
T3958	13974-13983	CL:0000576	denotes	monocytes
T3960	14002-14012	CL:0000767	denotes	basophiles
T3961	14038-14043	UBERON:0000178	denotes	blood
T3962	14074-14082	CL:0000233	denotes	platelet
T3963	14110-14124	UBERON:0000178	denotes	haematological
T3964	14164-14172	CL:0000233	denotes	platelet
T3965	14199-14204	PR:000004080	denotes	anxA7
T3966	14215-14219	NCBITaxon:10088	denotes	mice
T3967	14287-14295	CL:0000233	denotes	platelet
T3968	14316-14320	NCBITaxon:10088	denotes	mice
T3969	14411-14419	CL:0000233	denotes	platelet
T3970	14461-14467	NCBITaxon:9606	denotes	humans
T3971	14469-14477	CL:0000233	denotes	platelet
T3972	14651-14656	PR:000004080	denotes	anxA7
T3973	14712-14720	CL:0000233	denotes	platelet
T3974	14775-14783	CL:0000233	denotes	platelet
T3975	14789-14795	UBERON:0001969	denotes	plasma
T3976	14797-14805	CL:0000233	denotes	Platelet
T3977	14797-14816	GO:0030168	denotes	Platelet activation
T3978	14920-14930	GO:0031143	denotes	pseudopods
T3979	14969-14981	GO:0005856	denotes	cytoskeletal
T3980	15078-15086	CHEBI:75958	denotes	solution
T3981	15184-15192	CL:0000233	denotes	platelet
T3982	15184-15203	GO:0030168	denotes	platelet activation
T3983	15207-15217	CHEBI:85129	denotes	ristocetin
T3984	15243-15251	CHEBI:23357	denotes	cofactor
T3985	15341-15349	CL:0000233	denotes	platelet
T3986	15341-15360	GO:0030168	denotes	platelet initiation
T3987	15419-15429	PR:000004080	denotes	Annexin A7
T3988	15440-15449	CL:0000233	denotes	platelets
T3989	15541-15546	NCBITaxon:9606	denotes	human
T3990	15547-15556	CL:0000233	denotes	platelets
T3991	15609-15619	NCBITaxon:1	denotes	individual
T3992	15627-15648	PR:000017364	denotes	von Willebrand factor
T3993	15770-15775	NCBITaxon:10088	denotes	mouse
T3994	15776-15785	CL:0000233	denotes	platelets
T3995	15790-15795	PR:000004080	denotes	anxA7
T3996	15798-15807	CL:0000233	denotes	platelets
T3997	15835-15841	NCBITaxon:39107	denotes	murine
T3998	15842-15851	CL:0000233	denotes	platelets
T3999	15909-15914	NCBITaxon:9606	denotes	human
T4000	15915-15924	CL:0000233	denotes	platelets
T4727	17042-17052	PR:000004080	denotes	Annexin A7
T4728	17082-17089	GO:0031982	denotes	vesicle
T4729	17082-17096	GO:0006906	denotes	vesicle fusion
T4730	17104-17114	GO:0065007	denotes	regulating
T4731	17131-17147	GO:0044425	denotes	membrane domains
T4732	17191-17206	GO:0005886	denotes	plasma membrane
T4733	17217-17232	GO:0045121	denotes	raft subdomains
T4734	17267-17274	GO:0005829	denotes	cytosol
T4735	17308-17315	GO:0031982	denotes	vesicle
T4736	17384-17390	UBERON:0000479	denotes	tissue
T4737	17465-17475	GO:0010467	denotes	expression
T4738	17529-17537	SO:0001060	denotes	isoforms
T4739	17547-17556	GO:0010467	denotes	expressed
T4740	17568-17583	CL:0000232	denotes	Red blood cells
T4741	17572-17577	UBERON:0000178	denotes	blood
T4742	17620-17630	PR:000004080	denotes	annexin A7
T4743	17673-17680	SO:0001060	denotes	isoform
T4744	17715-17721	PR:000015619	denotes	sorcin
T4745	17764-17771	SO:0001060	denotes	isoform
T4746	17788-17803	CL:0000232	denotes	red blood cells
T4747	17792-17797	UBERON:0000178	denotes	blood
T4748	17842-17849	SO:0001060	denotes	isoform
T4749	17907-17917	PR:000004080	denotes	annexin A7
T4750	17921-17936	CL:0000232	denotes	red blood cells
T4751	17925-17930	UBERON:0000178	denotes	blood
T4752	17960-17970	PR:000004080	denotes	annexin A7
T4753	17975-17981	PR:000015619	denotes	sorcin
T4754	17999-18020	GO:0045121	denotes	membrane raft domains
T4755	18028-18036	GO:0031982	denotes	vesicles
T4756	18049-18064	CL:0000232	denotes	red blood cells
T4757	18053-18058	UBERON:0000178	denotes	blood
T4758	18075-18087	GO:0045121	denotes	Raft domains
T4759	18129-18137	GO:0016020	denotes	membrane
T4760	18172-18184	GO:0006900	denotes	vesiculation
T4761	18229-18242	CHEBI:26739	denotes	sphingolipids
T4762	18247-18258	CHEBI:16113	denotes	cholesterol
T4763	18272-18282	_FRAGMENT	denotes	leaflet of
T4764	18287-18295	GO:0097478	denotes	membrane
T4765	18309-18322	CHEBI:16247	denotes	phospholipids
T4766	18327-18338	CHEBI:16113	denotes	cholesterol
T4767	18352-18359	GO:0097478	denotes	leaflet
T4768	18412-18417	GO:0045121	denotes	rafts
T4769	18433-18442	GO:0016020	denotes	membranes
T4770	18484-18496	CHEBI:9750	denotes	Triton X-100
T4771	18536-18543	CHEBI:17992	denotes	sucrose
T4772	18614-18624	PR:000004080	denotes	annexin A7
T4773	18634-18642	GO:0016020	denotes	membrane
T4774	18675-18685	PR:000004080	denotes	annexin A7
T4775	18719-18731	GO:0006900	denotes	vesiculation
T4776	18787-18799	GO:0006900	denotes	vesiculation
T4777	18833-18843	PR:000004080	denotes	annexin A7
T4778	18919-18929	CHEBI:35195	denotes	surfactant
T4779	18933-18943	PR:000004080	denotes	annexin A7
T4780	19001-19011	PR:000004080	denotes	annexin A7
T4781	19015-19025	CHEBI:35195	denotes	surfactant
T4782	19058-19068	PR:000004080	denotes	annexin A7
T4783	19078-19086	GO:0016020	denotes	membrane
T4784	19078-19093	GO:0061025	denotes	membrane fusion
T4785	19162-19172	PR:000004080	denotes	annexin A7
T4786	19182-19187	NCBITaxon:10088	denotes	mouse
T4787	19217-19227	PR:000004080	denotes	annexin A7
T4788	19231-19241	_FRAGMENT	denotes	budding of
T4789	19257-19265	GO:0006900	denotes	vesicles
T4790	19242-19256	CL:0000232	denotes	red blood cell
T4791	19246-19251	UBERON:0000178	denotes	blood
T4792	19257-19265	GO:0031982	denotes	vesicles
T4793	19307-19313	_FRAGMENT	denotes	micro-
T4794	19322-19329	GO:1990742	denotes	vesicle
T4795	19395-19410	CL:0000232	denotes	red blood cells
T4796	19399-19404	UBERON:0000178	denotes	blood
T4797	19422-19446	NCBITaxon:44689	denotes	Dictyostelium discoideum
T4798	19482-19486	SO:0000704	denotes	gene
T4799	19545-19553	GO:0016020	denotes	membrane
T4800	19545-19560	GO:0061025	denotes	membrane fusion
T4801	19636-19648	CHEBI:16247	denotes	phospholipid
T4802	19659-19669	PR:000004080	denotes	annexin A7
T4803	19694-19698	CHEBI:29108	denotes	Ca2+
T4804	19786-19796	PR:000004080	denotes	annexin A7
T4805	19800-19806	_FRAGMENT	denotes	micro-
T4806	19815-19823	GO:1990742	denotes	vesicles
T4807	19879-19893	CL:0000232	denotes	red blood cell
T4808	19883-19888	UBERON:0000178	denotes	blood
T4809	19889-19902	GO:0005886	denotes	cell membrane
T4810	19915-19925	PR:000004080	denotes	annexin A7
T4811	19946-19950	CHEBI:29108	denotes	Ca2+
T4812	20007-20018	GO:0070382	denotes	exovesicles
T4813	20058-20068	PR:000004080	denotes	annexin A7
T4814	20069-20077	SO:0001060	denotes	isoforms
T4815	20094-20109	CL:0000232	denotes	red blood cells
T4816	20098-20103	UBERON:0000178	denotes	blood
T4817	20173-20182	GO:0016020	denotes	membranes
T4818	20186-20194	GO:0016020	denotes	membrane
T4819	20213-20223	PR:000004075	denotes	annexin A2
T4820	20251-20260	GO:0005768	denotes	endosomes
T4821	20287-20295	GO:0016020	denotes	membrane
T4822	20287-20302	GO:0061025	denotes	membrane fusion
T4823	20311-20320	GO:0005768	denotes	endosomal
T4824	20330-20340	PR:000004080	denotes	annexin A7
T4825	20358-20386	GO:0044853	denotes	plasma membrane raft domains
T4826	20439-20447	GO:0031982	denotes	vesicles
T4827	20451-20466	CL:0000232	denotes	red blood cells
T4828	20455-20460	UBERON:0000178	denotes	blood
T4829	20475-20485	PR:000004080	denotes	annexin A7
T4830	20500-20506	PR:000015619	denotes	sorcin
T4831	20579-20589	PR:000004080	denotes	annexin A7
T4832	20597-20607	GO:0010467	denotes	expression
T4833	20615-20629	CL:0000232	denotes	red blood cell
T4834	20615-20641	GO:0048821	denotes	red blood cell development
T4835	20619-20624	UBERON:0000178	denotes	blood
T4836	20688-20695	GO:0031982	denotes	vesicle
T4837	20688-20705	GO:0006900	denotes	vesicle formation
T4838	20710-20718	GO:0016020	denotes	membrane
T4839	20710-20725	GO:0061025	denotes	membrane fusion
T4840	20727-20737	PR:000004080	denotes	annexin A7
T4841	20767-20771	CHEBI:29108	denotes	Ca2+
T4842	20820-20830	PR:000004080	denotes	annexin A7
T4843	20859-20867	GO:0016020	denotes	membrane
T4844	20927-20937	PR:000004080	denotes	annexin A7
T4845	20975-20979	CHEBI:29108	denotes	Ca2+
T4846	20980-20991	GO:0042592	denotes	homeostasis
T4847	21009-21017	GO:0016020	denotes	membrane
T4848	21251-21261	PR:000004080	denotes	annexin A7
T4849	21286-21301	CL:0000232	denotes	red blood cells
T4850	21290-21295	UBERON:0000178	denotes	blood
T4851	21344-21359	CL:0000232	denotes	red blood cells
T4852	21348-21353	UBERON:0000178	denotes	blood
T4853	21417-21432	GO:0005886	denotes	plasma membrane
T4854	21441-21449	GO:0016020	denotes	membrane
T4855	21461-21468	_FRAGMENT	denotes	part of
T4856	21473-21485	GO:0044430	denotes	cytoskeleton
T4857	21521-21529	GO:0016020	denotes	membrane
T4858	21530-21538	GO:0005856	denotes	skeleton
T4859	21587-21602	GO:0005884	denotes	actin filaments
T4860	21650-21672	_FRAGMENT	denotes	cytoplasmic surface of
T4861	21687-21700	GO:0009898	denotes	cell membrane
T4862	21677-21691	CL:0000232	denotes	red blood cell
T4863	21681-21686	UBERON:0000178	denotes	blood
T4864	21707-21715	GO:0016020	denotes	Membrane
T4865	21716-21727	CHEBI:16113	denotes	cholesterol
T4866	21739-21753	CL:0000232	denotes	red blood cell
T4867	21743-21748	UBERON:0000178	denotes	blood
T4868	21772-21790	GO:0005579	denotes	complement complex
T4869	21813-21817	GO:0045121	denotes	raft
T4870	21818-21829	CHEBI:16113	denotes	cholesterol
T4871	21859-21863	GO:0045121	denotes	raft
T4872	21928-21941	GO:0005886	denotes	cell membrane
T4873	21969-21979	PR:000004080	denotes	Annexin A7
T4874	21990-21995	NCBITaxon:10088	denotes	mouse
T4875	21996-22011	CL:0000232	denotes	red blood cells
T4876	22000-22005	UBERON:0000178	denotes	blood
T4877	22089-22099	PR:000004080	denotes	annexin A7
T4878	22114-22122	GO:0016020	denotes	membrane
T4879	22177-22185	GO:0016020	denotes	membrane
T4880	22241-22251	PR:000004080	denotes	Annexin A7
T4881	22292-22307	GO:0005886	denotes	plasma membrane
T4882	22381-22385	CHEBI:29108	denotes	Ca2+
T4883	22390-22398	GO:0016020	denotes	membrane
T4884	22399-22407	GO:0005856	denotes	skeletal
T4885	22452-22466	CL:0000232	denotes	red blood cell
T4886	22456-22461	UBERON:0000178	denotes	blood
T4887	22462-22475	GO:0005886	denotes	cell membrane
T4888	22550-22557	GO:0031941	denotes	F-actin
T4889	22605-22615	PR:000004080	denotes	annexin A7
T4890	22704-22712	GO:0016020	denotes	membrane
T4891	22713-22725	GO:0005856	denotes	cytoskeleton
T4892	22727-22738	GO:0065007	denotes	controlling
T4893	22739-22743	GO:0045121	denotes	raft
T4894	22784-22789	CHEBI:24870	denotes	ionic
T4895	22802-22817	CL:0000232	denotes	red blood cells
T4896	22806-22811	UBERON:0000178	denotes	blood
T4897	22897-22907	PR:000004080	denotes	annexin A7
T4898	22933-22944	GO:0005737	denotes	cytoplasmic
T4899	22945-22949	CHEBI:29108	denotes	Ca2+
T4900	22950-22961	GO:0042592	denotes	homeostasis
T4901	23019-23032	GO:0005622	denotes	intracellular
T4902	23033-23037	CHEBI:29108	denotes	Ca2+
T4903	23083-23091	GO:0016020	denotes	membrane
T4904	23108-23116	GO:0065007	denotes	regulate
T4905	23117-23131	CL:0000232	denotes	red blood cell
T4906	23121-23126	UBERON:0000178	denotes	blood
T4907	23172-23185	GO:0005622	denotes	intracellular
T4908	23186-23190	CHEBI:29108	denotes	Ca2+
T4909	23204-23212	GO:0065007	denotes	regulate
T4910	23217-23225	GO:0016020	denotes	membrane
T4911	23244-23254	GO:0065007	denotes	modulation
T4912	23258-23270	GO:0005856	denotes	cytoskeletal
T4913	23298-23302	CHEBI:29108	denotes	Ca2+
T4914	23331-23343	CHEBI:16247	denotes	phospholipid
T4915	23386-23401	CL:0000232	denotes	red blood cells
T4916	23390-23395	UBERON:0000178	denotes	blood
T4917	23421-23430	CHEBI:29108	denotes	Ca2+ ions
T4918	23460-23468	GO:0016020	denotes	membrane
T4919	23499-23511	GO:0005856	denotes	cytoskeleton
T4920	23552-23560	CL:0000233	denotes	platelet
T4921	23577-23587	PR:000004080	denotes	annexin A7
T4922	23603-23611	CL:0000233	denotes	platelet
T4923	23603-23623	GO:0070527	denotes	platelet aggregation
T4924	23710-23719	CL:0000233	denotes	platelets
T4925	23728-23738	PR:000004080	denotes	annexin A7
T4926	23841-23847	NCBITaxon:39107	denotes	murine
T4927	23848-23857	CL:0000233	denotes	platelets
T4928	23887-23892	NCBITaxon:9606	denotes	human
T4929	23967-23972	NCBITaxon:10088	denotes	mouse
T4930	24008-24013	NCBITaxon:10088	denotes	mouse
T4931	24014-24023	CL:0000233	denotes	platelets
T4932	24114-24122	CHEBI:9574	denotes	thrombin
T4933	24167-24172	NCBITaxon:9606	denotes	human
T4934	24173-24176	PR:000017364	denotes	vWF
T4935	24195-24206	GO:0007599	denotes	haemostatic
T4936	24423-24431	CL:0000233	denotes	platelet
T4937	24452-24460	CL:0000233	denotes	platelet
T4938	24461-24468	CHEBI:59132	denotes	antigen
T6590	24580-24590	PR:000004080	denotes	annexin A7
T6591	24591-24599	SO:0001060	denotes	isoforms
T6592	24603-24618	CL:0000232	denotes	red blood cells
T6593	24607-24612	UBERON:0000178	denotes	blood
T6594	24650-24658	GO:0031982	denotes	vesicles
T6595	24674-24678	CHEBI:29108	denotes	Ca2+
T6596	24735-24747	GO:0006900	denotes	vesiculation
T6597	24815-24831	GO:0044425	denotes	membrane domains
T6598	24840-24845	CHEBI:18059	denotes	lipid
T6599	24840-24851	GO:0045121	denotes	lipid rafts
T6600	24886-24896	PR:000004080	denotes	annexin A7
T6601	24965-24974	GO:0016020	denotes	membranes
T6602	24988-25003	CL:0000232	denotes	red blood cells
T6603	24992-24997	UBERON:0000178	denotes	blood
T6604	25007-25012	PR:000004080	denotes	anxA7
T6605	25015-25019	NCBITaxon:10088	denotes	mice
T6606	25055-25067	CL:0000232	denotes	erythrocytes
T6607	25076-25086	PR:000004080	denotes	annexin A7
T6608	25122-25133	CL:0000232	denotes	erythrocyte
T6609	25134-25146	GO:0005856	denotes	cytoskeleton
T6610	25177-25184	GO:0031941	denotes	F-actin
T6611	25243-25247	CHEBI:29108	denotes	Ca2+
T6798	25291-25297	NCBITaxon:39107	denotes	murine
T6799	25302-25307	NCBITaxon:9606	denotes	human
T6800	25308-25313	UBERON:0000178	denotes	blood
T6801	25322-25327	UBERON:0000178	denotes	Blood
T6802	25353-25363	PR:000004080	denotes	annexin A7
T6803	25374-25378	NCBITaxon:10088	denotes	mice
T6804	25380-25385	PR:000004080	denotes	anxA7
T6805	25430-25433	GO:0007631	denotes	fed
T6806	25447-25451	CHEBI:33290	denotes	food
T6807	25522-25545	UBERON:0002080	denotes	right cardiac ventricle
T6808	25588-25596	UBERON:0005434	denotes	cervical
T6809	25610-25621	GO:0050817	denotes	Coagulation
T6810	25724-25728	NCBITaxon:10088	denotes	mice
T6811	25744-25752	UBERON:0005434	denotes	cervical
T6812	25797-25818	CHEBI:38867	denotes	anaesthetic chemicals
T6813	25822-25827	UBERON:0000178	denotes	blood
T6814	25865-25869	NCBITaxon:10088	denotes	mice
T6815	25935-25940	UBERON:0000178	denotes	blood
T6816	26042-26048	NCBITaxon:39107	denotes	murine
T6817	26049-26054	UBERON:0000178	denotes	blood
T6818	26137-26142	NCBITaxon:9606	denotes	Human
T6819	26143-26148	UBERON:0000178	denotes	blood
T6820	26192-26196	UBERON:0001638	denotes	vein
T6821	26339-26344	UBERON:0000178	denotes	blood
T6822	26380-26384	UBERON:0002415	denotes	tail
T6823	26389-26394	UBERON:0000948	denotes	heart
T6824	26476-26481	UBERON:0000178	denotes	blood
T6825	26515-26522	SO:0000704	denotes	genetic
T6826	26570-26574	NCBITaxon:10088	denotes	mice
T6827	26646-26650	NCBITaxon:10088	denotes	mice
T6828	26689-26696	SO:0000704	denotes	genetic
T6829	26725-26729	NCBITaxon:10088	denotes	mice
T6830	26773-26781	CL:0000233	denotes	platelet
T6831	26773-26793	GO:0070527	denotes	platelet aggregation
T6832	26815-26819	NCBITaxon:10088	denotes	mice
T7207	26879-26888	CHEBI:31705	denotes	iodixanol
T7208	26910-26915	NCBITaxon:9606	denotes	human
T7209	26916-26931	CL:0000232	denotes	red blood cells
T7210	26920-26925	UBERON:0000178	denotes	blood
T7211	26964-26974	PR:000004080	denotes	annexin A7
T7212	27008-27023	CL:0000232	denotes	Red blood cells
T7213	27012-27017	UBERON:0000178	denotes	blood
T7214	27110-27115	GO:0019835	denotes	lysis
T7215	27130-27135	CHEBI:46756	denotes	Hepes
T7216	27152-27157	CHEBI:3312	denotes	CaCl2
T7217	27166-27173	CHEBI:17992	denotes	sucrose
T7218	27321-27330	CHEBI:31705	denotes	iodixanol
T7219	27331-27339	CHEBI:75958	denotes	solution
T7220	27375-27383	CHEBI:75958	denotes	solution
T7221	27390-27399	CHEBI:31705	denotes	iodixanol
T7222	27428-27433	CHEBI:46756	denotes	Hepes
T7223	27450-27455	CHEBI:3312	denotes	CaCl2
T7224	27464-27471	CHEBI:17992	denotes	sucrose
T7225	27499-27508	CHEBI:31705	denotes	iodixanol
T7226	27509-27517	CHEBI:75958	denotes	solution
T7227	27556-27570	CL:0000232	denotes	red blood cell
T7228	27560-27565	UBERON:0000178	denotes	blood
T7229	27571-27579	CHEBI:75958	denotes	solution
T7230	27603-27611	CHEBI:75958	denotes	solution
T7231	27630-27639	CHEBI:31705	denotes	iodixanol
T7232	27645-27652	CHEBI:60004	denotes	mixture
T7233	27727-27736	CHEBI:31705	denotes	iodixanol
T7556	28073-28083	GO:0070382	denotes	Exovesicle
T7557	28100-28105	NCBITaxon:9606	denotes	human
T7558	28110-28116	NCBITaxon:39107	denotes	murine
T7559	28117-28132	CL:0000232	denotes	red blood cells
T7560	28121-28126	UBERON:0000178	denotes	blood
T7561	28133-28148	CL:0000232	denotes	Red blood cells
T7562	28137-28142	UBERON:0000178	denotes	blood
T7563	28190-28201	GO:0070382	denotes	exovesicles
T7564	28218-28225	GO:0031982	denotes	vesicle
T7565	28218-28235	GO:0006900	denotes	vesicle formation
T7566	28239-28243	CHEBI:29108	denotes	Ca2+
T7567	28279-28286	CHEBI:28304	denotes	heparin
T7568	28291-28301	GO:0050817	denotes	coagulated
T7569	28302-28307	UBERON:0000178	denotes	blood
T7570	28371-28383	CL:0000232	denotes	erythrocytes
T7571	28418-28423	CHEBI:46756	denotes	Hepes
T7572	28444-28448	CHEBI:26710	denotes	NaCl
T7573	28493-28508	CL:0000232	denotes	red blood cells
T7574	28497-28502	UBERON:0000178	denotes	blood
T7575	28536-28548	GO:0006900	denotes	vesiculation
T7576	28563-28568	CHEBI:46756	denotes	Hepes
T7577	28585-28589	CHEBI:26710	denotes	NaCl
T7578	28596-28601	CHEBI:3312	denotes	CaCl2
T7579	28619-28623	CHEBI:29108	denotes	Ca2+
T7580	28624-28633	CHEBI:24869	denotes	ionophore
T7581	28719-28727	CHEBI:75958	denotes	solution
T7582	29022-29036	CL:0000232	denotes	red blood cell
T7583	29026-29031	UBERON:0000178	denotes	blood
T7584	29037-29050	GO:1990742	denotes	microvesicles
T7585	29294-29302	GO:0031982	denotes	vesicles
T7586	29328-29336	GO:0031982	denotes	vesicles
T7587	29354-29367	CHEBI:15355	denotes	acetylcholine
T7922	29418-29431	CHEBI:15355	denotes	Acetylcholine
T7923	29465-29479	CL:0000232	denotes	red blood cell
T7924	29469-29474	UBERON:0000178	denotes	blood
T7925	29480-29488	GO:0031982	denotes	vesicles
T7926	29537-29542	CHEBI:46756	denotes	Hepes
T7927	29559-29563	CHEBI:26710	denotes	NaCl
T7928	29571-29583	CHEBI:9750	denotes	Triton X-100
T7929	29652-29668	CHEBI:37586	denotes	sodium phosphate
T7930	29707-29711	CHEBI:86228	denotes	DTNB
T7931	29713-29748	CHEBI:86228	denotes	5,5'-dithiobis-(2-nitrobenzoic acid
T7932	29760-29776	CHEBI:37586	denotes	sodium phosphate
T7933	29835-29838	CHEBI:15377	denotes	H2O
T8095	30038-30053	CL:0000232	denotes	red blood cells
T8096	30042-30047	UBERON:0000178	denotes	blood
T8097	30056-30063	CHEBI:34683	denotes	Na2HPO4
T8098	30064-30071	CHEBI:37585	denotes	NaH2PO4
T8099	30081-30085	CHEBI:26710	denotes	NaCl
T8100	30131-30135	CHEBI:26710	denotes	NaCl
T8101	30277-30285	CHEBI:75958	denotes	solution
T8102	30296-30301	UBERON:0000178	denotes	blood
T8267	30605-30613	CL:0000233	denotes	Platelet
T8268	30605-30625	GO:0070527	denotes	Platelet aggregation
T8269	30656-30662	NCBITaxon:39107	denotes	murine
T8270	30663-30668	UBERON:0000178	denotes	blood
T8271	30782-30790	CL:0000233	denotes	platelet
T8272	30796-30802	UBERON:0001969	denotes	plasma
T8273	30814-30822	CL:0000233	denotes	platelet
T8274	30814-30834	GO:0070527	denotes	platelet aggregation
T8275	31067-31072	CHEBI:46756	denotes	Hepes
T8276	31081-31085	CHEBI:26710	denotes	NaCl
T8277	31106-31115	CL:0000233	denotes	platelets
T8278	31131-31139	CL:0000233	denotes	platelet
T8279	31219-31225	NCBITaxon:39107	denotes	murine
T8280	31230-31235	NCBITaxon:9606	denotes	human
T8281	31261-31270	CL:0000233	denotes	platelets
T8282	31399-31409	CHEBI:85129	denotes	ristocetin
T8283	31410-31418	CHEBI:75958	denotes	solution
T8284	31497-31504	CHEBI:33893	denotes	reagent
T8285	31545-31550	NCBITaxon:10088	denotes	mouse
T8286	31555-31560	NCBITaxon:9606	denotes	human
T8287	31561-31570	CL:0000233	denotes	platelets
T8288	31577-31583	NCBITaxon:39107	denotes	murine
T8289	31613-31619	NCBITaxon:33208	denotes	animal
T8290	31633-31638	NCBITaxon:9606	denotes	human
T8291	31639-31644	UBERON:0000178	denotes	blood
T8292	31757-31773	NCBITaxon:9606	denotes	human individual
T8293	32025-32033	CL:0000233	denotes	platelet
T8294	32102-32107	UBERON:0000178	denotes	blood
T8657	32152-32165	GO:0030097	denotes	haematopoetic
T8658	32198-32204	NCBITaxon:39107	denotes	murine
T8659	32209-32214	NCBITaxon:9606	denotes	human
T8660	32215-32220	UBERON:0000178	denotes	blood
T8661	32245-32250	UBERON:0000178	denotes	blood
T8662	32336-32351	CL:0000232	denotes	red blood cells
T8663	32340-32345	UBERON:0000178	denotes	blood
T8664	32356-32365	CL:0000233	denotes	platelets
T8665	32468-32483	CL:0000232	denotes	red blood cells
T8666	32472-32477	UBERON:0000178	denotes	blood
T8667	32488-32497	CL:0000233	denotes	platelets
T8668	32603-32613	CL:0000738	denotes	leucocytes
T8669	32615-32630	CL:0000232	denotes	red blood cells
T8670	32619-32624	UBERON:0000178	denotes	blood
T8671	32748-32756	CL:0000233	denotes	platelet
T8672	32765-32777	CL:0000775	denotes	neutrophiles
T8673	32779-32790	CL:0000542	denotes	lymphocytes
T8674	32792-32801	CL:0000576	denotes	monocytes
T8675	32803-32815	CL:0000771	denotes	eosinophiles
T8676	32817-32827	CL:0000767	denotes	basophiles
T8677	32934-32944	PR:000004080	denotes	annexin A7
T8678	32977-32984	GO:0031941	denotes	F-actin
T8679	33008-33018	PR:000004080	denotes	annexin A7
T8680	33047-33050	CHEBI:8984	denotes	SDS
T8681	33176-33186	GO:0042571	denotes	Antibodies
T8682	33230-33235	NCBITaxon:10088	denotes	mouse
T8683	33236-33246	PR:000004080	denotes	annexin A7
T8684	33252-33258	SO:0000417	denotes	domain
T8685	33280-33286	NCBITaxon:9986	denotes	rabbit
T8686	33292-33298	PR:000015619	denotes	sorcin
T8687	33299-33307	GO:0042571	denotes	antibody
T9053	6100-6110	GO:0010467	denotes	Expression
T9054	6114-6124	PR:000004080	denotes	annexin A7
T9055	6128-6133	NCBITaxon:9606	denotes	human
T9056	6134-6149	CL:0000232	denotes	red blood cells
T9057	6138-6143	UBERON:0000178	denotes	blood
T9058	6158-6163	NCBITaxon:9606	denotes	human
T9059	6164-6173	CL:0000233	denotes	platelets
T9060	6217-6220	CHEBI:8984	denotes	SDS
T9061	6232-6242	CHEBI:28619	denotes	acrylamide
T9062	6345-6352	MOP:0000779	denotes	coupled
T9063	6353-6361	GO:0042571	denotes	antibody
T9064	6384-6392	SO:0001060	denotes	isoforms
T9065	6409-6424	CL:0000232	denotes	red blood cells
T9066	6413-6418	UBERON:0000178	denotes	blood
T9067	6429-6438	CL:0000233	denotes	platelets
T9068	6454-6461	SO:0001060	denotes	isoform
T9188	7830-7840	PR:000004080	denotes	annexin A7
T9189	7845-7851	PR:000015619	denotes	sorcin
T9190	7855-7866	GO:0070382	denotes	exovesicles
T9191	7880-7895	CL:0000232	denotes	red blood cells
T9192	7884-7889	UBERON:0000178	denotes	blood
T9193	7897-7905	GO:0031982	denotes	Vesicles
T9194	7930-7935	PR:000004080	denotes	anxA7
T9195	7971-7975	CHEBI:29108	denotes	Ca2+
T9196	7976-7985	CHEBI:24869	denotes	ionophore
T9197	8091-8097	PR:000015619	denotes	sorcin
T9198	8109-8117	GO:0042571	denotes	antibody
T9199	8131-8141	PR:000004080	denotes	annexin A7
T9200	8146-8152	PR:000015619	denotes	sorcin
T9201	8178-8186	GO:0031982	denotes	vesicles
T9202	8199-8206	SO:0001060	denotes	isoform
T9203	8210-8220	PR:000004080	denotes	annexin A7
T9204	8254-8262	GO:0031982	denotes	vesicles
T9205	8280-8288	GO:0031982	denotes	vesicles
T9206	8330-8343	CHEBI:15355	denotes	acetylcholine
T9207	8363-8368	NCBITaxon:9606	denotes	Human
T9208	8369-8384	CL:0000232	denotes	red blood cells
T9209	8373-8378	UBERON:0000178	denotes	blood
T9371	9304-9314	PR:000004080	denotes	annexin A7
T9372	9319-9325	PR:000015619	denotes	sorcin
T9373	9340-9354	CL:0000232	denotes	red blood cell
T9374	9344-9349	UBERON:0000178	denotes	blood
T9375	9355-9370	GO:0005886	denotes	plasma membrane
T9376	9382-9387	GO:0019835	denotes	Lysed
T9377	9388-9393	NCBITaxon:9606	denotes	human
T9378	9394-9409	CL:0000232	denotes	red blood cells
T9379	9398-9403	UBERON:0000178	denotes	blood
T9380	9439-9448	CHEBI:31705	denotes	iodixanol
T9381	9617-9623	PR:000015619	denotes	sorcin
T9382	9635-9643	GO:0042571	denotes	antibody
T9475	10429-10444	CL:0000232	denotes	red blood cells
T9476	10433-10438	UBERON:0000178	denotes	blood
T9477	10450-10455	PR:000004080	denotes	anxA7
T9478	10484-10488	NCBITaxon:10088	denotes	mice
T9570	12750-12765	CL:0000232	denotes	red blood cells
T9571	12754-12759	UBERON:0000178	denotes	blood
T9572	12785-12790	PR:000004080	denotes	anxA7
T9573	12801-12805	NCBITaxon:10088	denotes	mice
T9574	12853-12866	GO:0005576	denotes	extracellular
T9575	12867-12872	CHEBI:24870	denotes	ionic
T9576	12924-12938	CL:0000232	denotes	red blood cell
T9577	12928-12933	UBERON:0000178	denotes	blood
T9578	12970-12985	CHEBI:26710	denotes	sodium chloride
T9579	13009-13023	GO:0019835	denotes	cellular lysis
T9580	13069-13074	_FRAGMENT	denotes	lysis
T9581	13096-13098	_FRAGMENT	denotes	of
T9582	13111-13115	GO:0019835	denotes	cell
T9583	13101-13115	CL:0000232	denotes	red blood cell
T9584	13105-13110	UBERON:0000178	denotes	blood
T9585	13143-13153	PR:000004080	denotes	annexin A7
T9586	13164-13179	CL:0000232	denotes	red blood cells
T9587	13168-13173	UBERON:0000178	denotes	blood
T9740	15958-15966	CL:0000233	denotes	Platelet
T9741	15958-15978	GO:0070527	denotes	Platelet aggregation
T9742	15991-15999	CL:0000233	denotes	platelet
T9743	16005-16011	UBERON:0001969	denotes	plasma
T9744	16015-16025	PR:000004080	denotes	annexin A7
T9745	16050-16054	NCBITaxon:10088	denotes	mice
T9746	16159-16169	CHEBI:85129	denotes	ristocetin
T9747	16216-16224	CL:0000233	denotes	platelet
T9748	16408-16414	NCBITaxon:39107	denotes	murine
T9749	16482-16490	CL:0000233	denotes	platelet
T9750	16482-16501	GO:0030168	denotes	platelet initiation
T9751	16779-16785	NCBITaxon:39107	denotes	Murine
T9752	16786-16795	CL:0000233	denotes	platelets
T9753	16879-16884	NCBITaxon:9606	denotes	human
T9754	16885-16894	CL:0000233	denotes	platelets
T9755	16931-16939	CL:0000233	denotes	platelet
T9756	16969-16974	NCBITaxon:9606	denotes	human
T9757	16975-16984	CL:0000233	denotes	platelets
T3951	13757-13762	UBERON:0000178	denotes	blood
T3959	13985-13997	CL:0000771	denotes	eosinophiles
T2268	5899-5906	SO:0001060	denotes	isoform
T2281	6754-6765	GO:0070382	denotes	exovesicles
T2284	6934-6944	PR:000004080	denotes	annexin A7
T2285	6959-6970	GO:0070382	denotes	exovesicles
T727	27-31	CHEBI:29108	denotes	Ca2+
T784	1742-1752	GO:0006887	denotes	exocytosis
T858	4229-4233	CHEBI:29108	denotes	Ca2+
R2756	T4794	T4793	_lexicallyChainedTo	vesicle,micro-
R2757	T4806	T4805	_lexicallyChainedTo	vesicles,micro-
R2758	T4856	T4855	_lexicallyChainedTo	cytoskeleton,part of
R2759	T4861	T4860	_lexicallyChainedTo	cell membrane,cytoplasmic surface of
R6010	T9581	T9580	_lexicallyChainedTo	of,lysis
R6011	T9582	T9581	_lexicallyChainedTo	cell,of
R306	T731	T730	_lexicallyChainedTo	membranes,fusion of
R307	T772	T771	_lexicallyChainedTo	membrane,plasma
R308	T860	T859	_lexicallyChainedTo	exovesicles,release of
R309	T872	T871	_lexicallyChainedTo	vesicles,micro-
R1260	T2259	T2258	_lexicallyChainedTo	vesicles,micro-
R1261	T2287	T2286	_lexicallyChainedTo	vesicles,micro-
R1791	T3133	T3132	_lexicallyChainedTo	of,lysis
R1792	T3134	T3133	_lexicallyChainedTo	cells,of
R2754	T4764	T4763	_lexicallyChainedTo	membrane,leaflet of
R2755	T4789	T4788	_lexicallyChainedTo	vesicles,budding of

2_test

Id	Subject	Object	Predicate	Lexical cue
12925238-632306-8102376	319-320	632306	denotes	1
12925238-8155692-8102377	618-619	8155692	denotes	2
12925238-9223619-8102377	618-619	9223619	denotes	2
12925238-11917092-8102377	618-619	11917092	denotes	2
12925238-7738119-8102378	1372-1373	7738119	denotes	5
12925238-11338180-8102379	1374-1375	11338180	denotes	6
12925238-11895795-8102380	1642-1643	11895795	denotes	7
12925238-11454455-8102381	1754-1755	11454455	denotes	8
12925238-11454454-8102381	1754-1755	11454454	denotes	8
12925238-11152672-8102381	1754-1755	11152672	denotes	8
12925238-9268363-8102382	1841-1843	9268363	denotes	11
12925238-10767422-8102382	1841-1843	10767422	denotes	11
12925238-11839755-8102382	1841-1843	11839755	denotes	11
12925238-9441591-8102383	1931-1933	9441591	denotes	14
12925238-7592856-8102384	2121-2123	7592856	denotes	15
12925238-9268363-8102385	2285-2287	9268363	denotes	11
12925238-10767422-8102386	2643-2645	10767422	denotes	12
12925238-11839755-8102387	3151-3153	11839755	denotes	13
12925238-10570150-8102388	3573-3575	10570150	denotes	16
12925238-11390641-8102389	3705-3707	11390641	denotes	17
12925238-11895795-8102390	4138-4139	11895795	denotes	7
12925238-8702518-8102391	4255-4257	8702518	denotes	18
12925238-10733516-8102392	4258-4260	10733516	denotes	19
12925238-11895795-8102393	4366-4367	11895795	denotes	7
12925238-6781476-8102394	4368-4370	6781476	denotes	20
12925238-7678519-8102395	4630-4632	7678519	denotes	21
12925238-11895795-8102396	5023-5024	11895795	denotes	7
12925238-11895795-8102397	5679-5680	11895795	denotes	7
12925238-11895795-8102398	9015-9016	11895795	denotes	7
12925238-11798399-8102399	15943-15945	11798399	denotes	23
12925238-632306-8102400	17149-17150	632306	denotes	1
12925238-11338180-8102401	17558-17559	11338180	denotes	6
12925238-1825209-8102402	17560-17562	1825209	denotes	34
12925238-10672515-8102403	17563-17565	10672515	denotes	35
12925238-11895795-8102404	17723-17724	11895795	denotes	7
12925238-11895795-8102405	17866-17867	11895795	denotes	7
12925238-12208858-8102406	18569-18571	12208858	denotes	36
12925238-8855260-8102407	18605-18607	8855260	denotes	37
12925238-11290524-8102408	19147-19149	11290524	denotes	38
12925238-7657724-8102409	19563-19565	7657724	denotes	39
12925238-11390641-8102410	20789-20791	11390641	denotes	17
12925238-3862123-8102411	21487-21489	3862123	denotes	40
12925238-1540701-8102411	21487-21489	1540701	denotes	40
12925238-8211222-8102411	21487-21489	8211222	denotes	40
12925238-8434261-8102412	21702-21704	8434261	denotes	44
12925238-9761744-8102413	21961-21963	9761744	denotes	45
12925238-11352913-8102414	21964-21966	11352913	denotes	46
12925238-1398703-8102415	22497-22499	1398703	denotes	47
12925238-154737-8102416	23147-23149	154737	denotes	48
12925238-9435486-8102417	23150-23152	9435486	denotes	49
12925238-3403710-8102418	23293-23295	3403710	denotes	50
12925238-8003498-8102419	23403-23405	8003498	denotes	51
12925238-7131536-8102420	23513-23515	7131536	denotes	52
12925238-11713907-8102421	24135-24137	11713907	denotes	22
12925238-11713907-8102422	26501-26503	11713907	denotes	22
12925238-11798399-8102423	26860-26862	11798399	denotes	23
12925238-7978280-8102424	27003-27005	7978280	denotes	24
12925238-7978280-8102425	27903-27905	7978280	denotes	24
12925238-11895795-8102426	29317-29318	11895795	denotes	7
12925238-6781476-8102427	29319-29321	6781476	denotes	20
12925238-14056485-8102428	30911-30913	14056485	denotes	26
12925238-9231902-8102429	32972-32974	9231902	denotes	27
12925238-12374734-8102430	33042-33044	12374734	denotes	28
12925238-5432063-8102431	33101-33103	5432063	denotes	29
12925238-388439-8102432	33104-33106	388439	denotes	30
12925238-11390641-8102433	33171-33173	11390641	denotes	17
12925238-7738119-8102434	33260-33261	7738119	denotes	5
12925238-10651630-8102435	33309-33311	10651630	denotes	31

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T895	27-31	CHEBI:29108	denotes	Ca2+
T896	37-49	CHEBI:16247	denotes	phospholipid
T897	50-57	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T898	58-65	CHEBI_PR_EXT:protein	denotes	protein
T899	128-147	GO:0042583	denotes	chromaffin granules
T900	152-161	_FRAGMENT	denotes	fusion of
T901	175-184	GO:0061025	denotes	membranes
T902	162-174	CHEBI:16247	denotes	phospholipid
T903	175-184	GO:0016020	denotes	membranes
T904	204-208	CHEBI:29108	denotes	Ca2+
T905	247-257	PR_EXT:000004080	denotes	annexin A7
T906	279-289	GO:0006887	denotes	exocytotic
T907	290-299	GO_EXT:secretion_entity_or_process	denotes	secretion
T908	303-317	CHEBI:33567	denotes	catecholamines
T909	327-334	CHEBI_PR_EXT:protein	denotes	protein
T910	358-382	SO_EXT:biological_conservation_process_or_quality	denotes	evolutionarily conserved
T911	383-391	CHEBI_PR_EXT:protein	denotes	proteins
T912	433-443	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T913	450-459	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T914	460-470	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T915	471-477	SO_EXT:0000417	denotes	domain
T916	483-493	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T917	494-500	SO_EXT:0000417	denotes	domain
T918	524-528	CHEBI:29108	denotes	Ca2+
T919	534-546	CHEBI:16247	denotes	phospholipid
T920	547-554	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T921	560-570	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T922	571-577	SO_EXT:0000417	denotes	domain
T923	628-635	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T924	639-671	CHEBI:62643	denotes	negatively charged phospholipids
T925	701-710	CHEBI:29108	denotes	Ca2+ ions
T926	712-722	PR_EXT:000004080	denotes	Annexin A7
T927	792-806	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	amino terminus
T928	826-837	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T929	839-859	GO:0000380	denotes	Alternative splicing
T930	878-886	SO_EXT:0001060	denotes	isoforms
T931	910-918	SO_EXT:0001060	denotes	isoforms
T932	952-956	SO_EXT:0000147	denotes	exon
T933	991-1001	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T934	1002-1008	SO_EXT:0000417	denotes	domain
T935	1015-1022	UBERON:0000479	denotes	tissues
T936	1046-1053	SO_EXT:0001060	denotes	isoform
T937	1079-1084	UBERON:0000955	denotes	brain
T938	1089-1094	UBERON:0000948	denotes	heart
T939	1112-1119	SO_EXT:0001060	denotes	isoform
T940	1135-1144	GO:0010467	denotes	expressed
T941	1155-1170	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T942	1179-1187	CL_GO_EXT:cell	denotes	cellular
T943	1194-1204	PR_EXT:000004080	denotes	annexin A7
T944	1228-1235	GO:0005829	denotes	cytosol
T945	1244-1259	GO:0005886	denotes	plasma membrane
T946	1272-1279	GO:0005634	denotes	nucleus
T947	1284-1293	GO:0031982	denotes	vesicular
T948	1315-1322	UBERON:0002369	denotes	adrenal
T949	1323-1342	GO:0042583	denotes	chromaffin granules
T950	1355-1363	GO:0030315	denotes	t-tubule
T951	1378-1388	PR_EXT:000004080	denotes	Annexin A7
T952	1389-1401	GO_EXT:biological_movement_or_translocation_process	denotes	translocates
T953	1405-1414	GO:0016020	denotes	membranes
T954	1420-1424	CHEBI:29108	denotes	Ca2+
T955	1453-1466	GO:0005622	denotes	intracellular
T956	1458-1466	CL_GO_EXT:cell	denotes	cellular
T957	1467-1471	CHEBI:29108	denotes	Ca2+
T958	1519-1525	_FRAGMENT	denotes	plasma
T959	1542-1550	GO:0005886	denotes	membrane
T960	1534-1550	GO:0031965	denotes	nuclear membrane
T961	1565-1578	GO:0005622	denotes	intracellular
T962	1570-1578	CL_GO_EXT:cell	denotes	cellular
T963	1579-1587	GO:0031982	denotes	vesicles
T964	1602-1612	PR_EXT:000004080	denotes	annexin A7
T965	1629-1634	CHEBI:18059	denotes	lipid
T966	1629-1640	GO:0045121	denotes	lipid rafts
T967	1646-1651	CHEBI:18059	denotes	Lipid
T968	1646-1657	GO:0045121	denotes	Lipid rafts
T969	1677-1685	GO:0016020	denotes	membrane
T970	1677-1693	GO:0006900	denotes	membrane budding
T971	1701-1713	GO:0006900	denotes	vesiculation
T972	1742-1752	GO:0006887	denotes	exocytosis
T973	1765-1772	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T974	1785-1795	PR_EXT:000004080	denotes	annexin A7
T975	1818-1824	PR_EXT:000015619	denotes	sorcin
T976	1829-1839	PR_EXT:000009771	denotes	galectin-3
T977	1849-1855	PR_EXT:000015619	denotes	Sorcin
T978	1861-1865	CHEBI:29108	denotes	Ca2+
T979	1866-1873	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T980	1874-1881	CHEBI_PR_EXT:protein	denotes	protein
T981	1915-1922	CHEBI_PR_EXT:protein	denotes	protein
T982	1941-1951	PR_EXT:000004080	denotes	annexin A7
T983	1955-1960	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T984	1964-1973	GO:0016020	denotes	membranes
T985	1979-1983	CHEBI:29108	denotes	Ca2+
T986	2002-2008	PR_EXT:000015619	denotes	Sorcin
T987	2063-2072	CHEBI:8925	denotes	ryanodine
T988	2073-2081	GO_EXT:0004872	denotes	receptor
T989	2098-2106	GO:0065007	denotes	modulate
T990	2147-2153	PR_EXT:000015619	denotes	sorcin
T991	2154-2164	PR_EXT:000004080	denotes	annexin A7
T992	2184-2193	CHEBI:8925	denotes	ryanodine
T993	2194-2202	GO_EXT:0004872	denotes	receptor
T994	2215-2221	PR_EXT:000015619	denotes	Sorcin
T995	2226-2236	PR_EXT:000004080	denotes	annexin A7
T996	2243-2252	GO:0010467	denotes	expressed
T997	2260-2267	UBERON:0000479	denotes	tissues
T998	2294-2301	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T999	2305-2315	PR_EXT:000004080	denotes	annexin A7
T1000	2320-2326	PR_EXT:000015619	denotes	sorcin
T1001	2330-2334	CHEBI:29108	denotes	Ca2+
T1002	2370-2374	CHEBI:29108	denotes	Ca2+
T1003	2395-2402	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T1004	2395-2408	SO_EXT:0000409	denotes	binding sites
T1005	2436-2450	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	amino terminal
T1006	2465-2471	SO_EXT:sequence_or_structure_motif	denotes	motifs
T1007	2475-2481	PR_EXT:000015619	denotes	sorcin
T1008	2498-2503	SO_EXT:sequence_or_structure_motif	denotes	motif
T1009	2511-2525	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	amino terminus
T1010	2529-2539	PR_EXT:000004080	denotes	annexin A7
T1011	2545-2553	CHEBI_PR_EXT:protein	denotes	proteins
T1012	2554-2558	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T1013	2601-2607	PR_EXT:000015619	denotes	sorcin
T1014	2608-2617	CHEBI:36357	denotes	molecules
T1015	2622-2632	PR_EXT:000004080	denotes	annexin A7
T1016	2633-2641	CHEBI:36357	denotes	molecule
T1017	2648-2658	PR_EXT:000009771	denotes	Galectin-3
T1018	2690-2697	CHEBI_PR_EXT:protein	denotes	protein
T1019	2711-2720	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T1020	2743-2762	GO:0005615	denotes	extracellular space
T1021	2748-2756	CL_GO_EXT:cell	denotes	cellular
T1022	2771-2778	GO:0005634	denotes	nucleus
T1023	2783-2792	GO:0005737	denotes	cytoplasm
T1024	2800-2812	GO:0005739	denotes	mitochondria
T1025	2814-2825	GO:0005737	denotes	Cytoplasmic
T1026	2826-2836	PR_EXT:000009771	denotes	galectin-3
T1027	2884-2897	GO:0005739	denotes	mitochondrial
T1028	2909-2924	GO_EXT:negative_regulation	denotes	Down regulation
T1029	2928-2938	PR_EXT:000004080	denotes	annexin A7
T1030	2948-2958	PR_EXT:000009771	denotes	galectin-3
T1031	2959-2972	GO_EXT:biological_translocation_entity_or_process	denotes	translocation
T1032	2980-3000	GO:0005640	denotes	perinuclear membrane
T1033	3015-3025	PR_EXT:000009771	denotes	galectin-3
T1034	3026-3035	GO_EXT:secretion_entity_or_process	denotes	secretion
T1035	3041-3051	PR_EXT:000004080	denotes	annexin A7
T1036	3063-3073	PR_EXT:000009771	denotes	galectin-3
T1037	3074-3085	GO_EXT:biological_routing_or_transport	denotes	trafficking
T1038	3087-3107	GO:0042981	denotes	apoptosis regulation
T1039	3113-3126	GO:0005739	denotes	mitochondrial
T1040	3160-3168	CL_GO_EXT:cell	denotes	cellular
T1041	3177-3187	PR_EXT:000004080	denotes	annexin A7
T1042	3229-3237	GO:0065007	denotes	regulate
T1043	3252-3268	GO:0044425	denotes	membrane domains
T1044	3291-3295	CHEBI:29108	denotes	Ca2+
T1045	3296-3307	GO:0042592	denotes	homeostasis
T1046	3312-3316	CHEBI:29108	denotes	Ca2+
T1047	3312-3345	GO:0019722	denotes	Ca2+-dependent signaling pathways
T1048	3411-3421	PR_EXT:000004080	denotes	annexin A7
T1049	3432-3437	NCBITaxon:10088	denotes	mouse
T1050	3438-3445	SO_EXT:sequence_altered_entity	denotes	mutants
T1051	3451-3461	PR_EXT:000004080	denotes	annexin A7
T1052	3468-3472	SO_EXT:sequence_nullness	denotes	null
T1053	3473-3477	NCBITaxon:10088	denotes	mice
T1054	3580-3586	GO_EXT:fatality_or_lethality	denotes	lethal
T1055	3601-3605	NCBITaxon:10088	denotes	mice
T1056	3617-3624	PR_EXT:000045358	denotes	insulin
T1057	3625-3634	GO_EXT:secretion_entity_or_process	denotes	secretion
T1058	3668-3672	SO_EXT:sequence_nullness	denotes	null
T1059	3742-3749	PR_EXT:000045358	denotes	insulin
T1060	3750-3759	GO_EXT:secretion_entity_or_process	denotes	secretion
T1061	3814-3828	CL:0000746	denotes	cardiomyocytes
T1062	3916-3931	CL:0000232	denotes	red blood cells
T1063	3920-3925	UBERON:0000178	denotes	blood
T1064	3926-3931	CL_GO_EXT:cell	denotes	cells
T1065	3936-3945	CL:0000233	denotes	platelets
T1066	3953-3958	PR_EXT:000004080	denotes	anxA7
T1067	3958-3959	SO_EXT:sequence_nullness_or_absence	denotes	-
T1068	3960-3961	SO_EXT:sequence_nullness_or_absence	denotes	-
T1069	3962-3968	SO_EXT:sequence_altered_entity	denotes	mutant
T1070	3981-3996	CL:0000232	denotes	red blood cells
T1071	3985-3990	UBERON:0000178	denotes	blood
T1072	3991-3996	CL_GO_EXT:cell	denotes	cells
T1073	4001-4010	CL:0000233	denotes	platelets
T1074	4039-4049	PR_EXT:000004080	denotes	annexin A7
T1075	4079-4086	SO_EXT:0001060	denotes	isoform
T1076	4121-4136	CL:0000232	denotes	red blood cells
T1077	4125-4130	UBERON:0000178	denotes	blood
T1078	4131-4136	CL_GO_EXT:cell	denotes	cells
T1079	4142-4157	CL:0000232	denotes	Red blood cells
T1080	4146-4151	UBERON:0000178	denotes	blood
T1081	4152-4157	CL_GO_EXT:cell	denotes	cells
T1082	4174-4185	CHEBI_EXT:biochemical	denotes	biochemical
T1083	4229-4233	CHEBI:29108	denotes	Ca2+
T1084	4282-4292	_FRAGMENT	denotes	release of
T1085	4315-4326	GO:0006887	denotes	exovesicles
T1086	4293-4303	CHEBI_GO_EXT:hemoglobin	denotes	hemoglobin
T1087	4315-4326	GO:0070382	denotes	exovesicles
T1088	4437-4451	CL:0000232	denotes	red blood cell
T1089	4441-4446	UBERON:0000178	denotes	blood
T1090	4447-4451	CL_GO_EXT:cell	denotes	cell
T1091	4508-4523	CL:0000232	denotes	Red blood cells
T1092	4512-4517	UBERON:0000178	denotes	blood
T1093	4518-4523	CL_GO_EXT:cell	denotes	cells
T1094	4550-4560	GO:0006900	denotes	vesiculate
T1095	4582-4596	CL:0000232	denotes	red blood cell
T1096	4586-4591	UBERON:0000178	denotes	blood
T1097	4592-4596	CL_GO_EXT:cell	denotes	cell
T1098	4592-4608	GO:0008219	denotes	cell destruction
T1099	4660-4668	GO:0031982	denotes	vesicles
T1100	4670-4676	_FRAGMENT	denotes	micro-
T1101	4685-4693	GO:1990742	denotes	vesicles
T1102	4762-4773	CHEBI:16113	denotes	cholesterol
T1103	4778-4790	CHEBI:26739	denotes	sphingolipid
T1104	4796-4801	CHEBI:18059	denotes	lipid
T1105	4796-4814	GO:0045121	denotes	lipid raft domains
T1106	4840-4848	CHEBI_PR_EXT:protein	denotes	proteins
T1107	4854-4874	GO_PR_EXT:acetylcholinesterase	denotes	acetylcholinesterase
T1108	4876-4880	CL_GO_EXT:cell	denotes	cell
T1109	4876-4888	GO:0009986	denotes	cell surface
T1110	4889-4897	CHEBI_PR_EXT:protein	denotes	proteins
T1111	4910-4929	GO_EXT:0004875	denotes	complement receptor
T1112	4939-4944	CHEBI:18059	denotes	lipid
T1113	4939-4949	GO:0045121	denotes	lipid raft
T1114	4950-4958	CHEBI_PR_EXT:protein	denotes	proteins
T1115	4959-4967	PR_EXT:000015763	denotes	stomatin
T1116	4972-4981	PR_EXT:flotillin	denotes	flotillin
T1117	5001-5013	GO:0005856	denotes	cytoskeletal
T1118	5014-5021	CHEBI_PR_EXT:protein	denotes	protein
T1119	5053-5059	PR_EXT:000015619	denotes	sorcin
T1120	5064-5074	PR_EXT:000004080	denotes	annexin A7
T1121	5091-5096	CHEBI:18059	denotes	lipid
T1122	5091-5102	GO:0045121	denotes	lipid rafts
T1123	5109-5117	CHEBI_PR_EXT:protein	denotes	proteins
T1124	5143-5151	GO:0031982	denotes	vesicles
T1125	5157-5164	GO:0031982	denotes	vesicle
T1126	5157-5174	GO:0006900	denotes	vesicle formation
T1127	5220-5234	CL:0000232	denotes	red blood cell
T1128	5224-5229	UBERON:0000178	denotes	blood
T1129	5230-5234	CL_GO_EXT:cell	denotes	cell
T1130	5240-5252	GO:0005856	denotes	cytoskeletal
T1131	5287-5299	CHEBI:16247	denotes	phospholipid
T1132	5319-5327	CL_GO_EXT:cell	denotes	cellular
T1133	5319-5336	GO:0005886	denotes	cellular membrane
T2333	5348-5358	PR_EXT:000004080	denotes	Annexin A7
T2334	5359-5369	GO:0010467	denotes	expression
T2335	5373-5388	CL:0000232	denotes	red blood cells
T2336	5377-5382	UBERON:0000178	denotes	blood
T2337	5383-5388	CL_GO_EXT:cell	denotes	cells
T2338	5390-5404	CL:0000232	denotes	red blood cell
T2339	5394-5399	UBERON:0000178	denotes	blood
T2340	5400-5404	CL_GO_EXT:cell	denotes	cell
T2341	5413-5424	GO:0070382	denotes	exovesicles
T2342	5432-5441	CL:0000233	denotes	platelets
T2343	5501-5508	SO_EXT:0001060	denotes	isoform
T2344	5512-5522	PR_EXT:000004080	denotes	annexin A7
T2345	5539-5545	PR_EXT:000015619	denotes	sorcin
T2346	5549-5555	_FRAGMENT	denotes	micro-
T2347	5564-5572	GO:1990742	denotes	vesicles
T2348	5586-5601	CL:0000232	denotes	red blood cells
T2349	5590-5595	UBERON:0000178	denotes	blood
T2350	5596-5601	CL_GO_EXT:cell	denotes	cells
T2351	5632-5637	GO_UBERON_EXT:lumen	denotes	lumen
T2352	5663-5677	GO:0045121	denotes	membrane rafts
T2353	5749-5756	SO_EXT:0001060	denotes	isoform
T2354	5797-5802	NCBITaxon:9606	denotes	human
T2355	5803-5818	CL:0000232	denotes	red blood cells
T2356	5807-5812	UBERON:0000178	denotes	blood
T2357	5813-5818	CL_GO_EXT:cell	denotes	cells
T2358	5837-5845	SO_EXT:0001060	denotes	isoforms
T2359	5899-5906	SO_EXT:0001060	denotes	isoform
T2360	5923-5929	CHEBI_EXT:silver	denotes	silver
T2361	5965-5975	PR_EXT:000004080	denotes	annexin A7
T2395	7329-7338	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T2397	7357-7362	UBERON:0000178	denotes	blood
T2398	7363-7367	CL_GO_EXT:cell	denotes	cell
T2399	7368-7376	GO:0031982	denotes	vesicles
T2400	7398-7402	GO_PR_EXT:acetylcholinesterase	denotes	AChE
T2401	7420-7428	GO:0031982	denotes	vesicles
T2402	7442-7455	GO:1990742	denotes	microvesicles
T2403	7473-7475	SO_EXT:wild_type_entity	denotes	wt
T2404	7501-7511	PR_EXT:000004080	denotes	annexin A7
T2405	7552-7561	GO:0016020	denotes	membranes
T2406	7621-7635	CL:0000232	denotes	red blood cell
T2407	7625-7630	UBERON:0000178	denotes	blood
T2408	7631-7635	CL_GO_EXT:cell	denotes	cell
T2409	7636-7647	GO:0070382	denotes	exovesicles
T2410	7684-7690	PR_EXT:000015619	denotes	sorcin
T2411	7694-7703	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T2412	7708-7714	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T2413	7715-7723	GO:0031982	denotes	vesicles
T2414	7742-7748	PR_EXT:000015619	denotes	sorcin
T2415	7776-7782	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T2416	7787-7795	GO:0031982	denotes	vesicles
T3175	9681-9686	UBERON:0000178	denotes	blood
T3176	9687-9691	CL_GO_EXT:cell	denotes	cell
T3177	9729-9739	PR_EXT:000004080	denotes	annexin A7
T3178	9758-9772	CL:0000232	denotes	red blood cell
T3179	9762-9767	UBERON:0000178	denotes	blood
T3180	9768-9772	CL_GO_EXT:cell	denotes	cell
T3181	9773-9781	GO:0031982	denotes	vesicles
T3182	9829-9836	CHEBI_PR_EXT:protein	denotes	protein
T3183	9844-9849	PR_EXT:000004080	denotes	anxA7
T3184	9849-9850	SO_EXT:sequence_nullness_or_absence	denotes	-
T3185	9851-9852	SO_EXT:sequence_nullness_or_absence	denotes	-
T3186	9852-9857	NCBITaxon:10088	denotes	mouse
T3187	9862-9876	CL:0000232	denotes	red blood cell
T3188	9866-9871	UBERON:0000178	denotes	blood
T3189	9872-9876	CL_GO_EXT:cell	denotes	cell
T3190	9927-9932	UBERON:0000178	denotes	blood
T3191	9977-9982	CL_GO_EXT:cell	denotes	cells
T3192	10060-10065	PR_EXT:000004080	denotes	anxA7
T3193	10065-10066	SO_EXT:sequence_nullness_or_absence	denotes	-
T3194	10067-10068	SO_EXT:sequence_nullness_or_absence	denotes	-
T3195	10068-10083	CL:0000232	denotes	red blood cells
T3196	10072-10077	UBERON:0000178	denotes	blood
T3197	10078-10083	CL_GO_EXT:cell	denotes	cells
T3198	10129-10133	CL_GO_EXT:cell	denotes	cell
T3199	10165-10174	SO_EXT:wild_type_entity	denotes	wild type
T3200	10380-10384	CL_GO_EXT:cell	denotes	cell
T3201	10661-10675	CL:0000232	denotes	red blood cell
T3202	10665-10670	UBERON:0000178	denotes	blood
T3203	10671-10675	CL_GO_EXT:cell	denotes	cell
T3204	10715-10724	UBERON:0001982	denotes	capillary
T3205	10725-10732	GO_EXT:biological_movement_or_translocation_process	denotes	passage
T3206	10805-10813	GO:0016020	denotes	membrane
T3207	10814-10819	CHEBI:18059	denotes	lipid
T3238	11586-11596	PR_EXT:000004080	denotes	annexin A7
T3239	11607-11622	CL:0000232	denotes	red blood cells
T3240	11611-11616	UBERON:0000178	denotes	blood
T3241	11617-11622	CL_GO_EXT:cell	denotes	cells
T3242	11662-11671	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T3243	11672-11677	CL_GO_EXT:cell	denotes	cells
T3244	11721-11726	CL_GO_EXT:cell	denotes	cells
T3245	11751-11755	CHEBI:26710	denotes	NaCl
T3246	11756-11764	CHEBI:75958	denotes	solution
T3247	11783-11792	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T3248	11793-11798	CL_GO_EXT:cell	denotes	cells
T3249	11839-11843	CHEBI:26710	denotes	NaCl
T3250	11844-11852	CHEBI:75958	denotes	solution
T3251	11882-11886	CHEBI:26710	denotes	NaCl
T3252	11891-11900	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T3253	11901-11906	CL_GO_EXT:cell	denotes	cells
T3254	11988-11993	CL_GO_EXT:cell	denotes	cells
T3255	12038-12042	CHEBI:26710	denotes	NaCl
T3256	12043-12051	CHEBI:75958	denotes	solution
T3257	12099-12113	CL:0000232	denotes	red blood cell
T3258	12103-12108	UBERON:0000178	denotes	blood
T3259	12109-12122	GO:0005886	denotes	cell membrane
T3260	12181-12191	PR_EXT:000004080	denotes	annexin A7
T3261	12199-12207	GO:0016020	denotes	membrane
T3262	12305-12320	CL:0000232	denotes	red blood cells
T3263	12309-12314	UBERON:0000178	denotes	blood
T3264	12315-12320	CL_GO_EXT:cell	denotes	cells
T3265	12427-12435	GO:0016020	denotes	membrane
T3266	12449-12454	GO:0019835	denotes	lysis
T3267	12694-12709	CL:0000232	denotes	red blood cells
T3268	12698-12703	UBERON:0000178	denotes	blood
T3269	12704-12709	CL_GO_EXT:cell	denotes	cells
T3270	13286-13296	PR_EXT:000004080	denotes	annexin A7
T3271	13325-13340	CL:0000232	denotes	red blood cells
T3272	13329-13334	UBERON:0000178	denotes	blood
T3273	13335-13340	CL_GO_EXT:cell	denotes	cells
T3274	13395-13402	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T3275	13406-13416	PR_EXT:000004080	denotes	annexin A7
T3276	13420-13427	GO:0031941	denotes	F-actin
T3277	13488-13496	GO:0016020	denotes	membrane
T3278	13530-13533	CHEBI:24870	denotes	ion
T3279	13530-13545	GO:0050801	denotes	ion homeostasis
T4001	13560-13570	PR_EXT:000004080	denotes	annexin A7
T4002	13587-13598	GO:0007599	denotes	haemostasis
T4003	13641-13645	CL_GO_EXT:cell	denotes	cell
T4004	13750-13756	NCBITaxon:39107	denotes	murine
T4005	13757-13762	UBERON:0000178	denotes	blood
T4006	13783-13793	CL:0000738	denotes	leukocytes
T4007	13795-13810	CL:0000232	denotes	red blood cells
T4008	13799-13804	UBERON:0000178	denotes	blood
T4009	13805-13810	CL_GO_EXT:cell	denotes	cells
T4010	13812-13823	CHEBI_GO_EXT:hemoglobin	denotes	haemoglobin
T4011	13851-13859	CL_GO_EXT:cell	denotes	cellular
T4012	13873-13881	CL_GO_EXT:cell	denotes	cellular
T4013	13882-13893	CHEBI_GO_EXT:hemoglobin	denotes	haemoglobin
T4014	13900-13908	CL_GO_EXT:cell	denotes	cellular
T4015	13909-13920	CHEBI_GO_EXT:hemoglobin	denotes	haemoglobin
T4016	13936-13945	CL:0000233	denotes	platelets
T4017	13947-13959	CL:0000775	denotes	neutrophiles
T4018	13961-13972	CL:0000542	denotes	lymphocytes
T4019	13974-13983	CL:0000576	denotes	monocytes
T4020	13985-13997	CL:0000771	denotes	eosinophiles
T4021	14002-14012	CL:0000767	denotes	basophiles
T4022	14038-14043	UBERON:0000178	denotes	blood
T4023	14074-14082	CL:0000233	denotes	platelet
T4024	14110-14124	UBERON:0000178	denotes	haematological
T4025	14164-14172	CL:0000233	denotes	platelet
T4026	14185-14194	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T4027	14199-14204	PR_EXT:000004080	denotes	anxA7
T4028	14204-14205	SO_EXT:sequence_nullness_or_absence	denotes	-
T4029	14206-14207	SO_EXT:sequence_nullness_or_absence	denotes	-
T4030	14208-14214	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4031	14215-14219	NCBITaxon:10088	denotes	mice
T4032	14287-14295	CL:0000233	denotes	platelet
T4033	14316-14320	NCBITaxon:10088	denotes	mice
T4034	14379-14388	SO_EXT:wild_type_entity	denotes	wild type
T4035	14411-14419	CL:0000233	denotes	platelet
T4036	14461-14467	NCBITaxon:9606	denotes	humans
T4037	14469-14477	CL:0000233	denotes	platelet
T4038	14651-14656	PR_EXT:000004080	denotes	anxA7
T4039	14656-14657	SO_EXT:sequence_nullness_or_absence	denotes	-
T4040	14658-14659	SO_EXT:sequence_nullness_or_absence	denotes	-
T4041	14712-14720	CL:0000233	denotes	platelet
T4042	14775-14783	CL:0000233	denotes	platelet
T4043	14789-14795	UBERON:0001969	denotes	plasma
T4044	14797-14805	CL:0000233	denotes	Platelet
T4045	14797-14816	GO:0030168	denotes	Platelet activation
T4046	14909-14914	CL_GO_EXT:cell	denotes	cells
T4047	14920-14930	GO:0031143	denotes	pseudopods
T4048	14969-14981	GO:0005856	denotes	cytoskeletal
T4049	15021-15026	CL_GO_EXT:cell	denotes	cells
T4050	15043-15053	GO_EXT:biological_recruitment	denotes	recruiting
T4051	15065-15070	CL_GO_EXT:cell	denotes	cells
T4052	15078-15086	CHEBI:75958	denotes	solution
T4053	15184-15192	CL:0000233	denotes	platelet
T4054	15184-15203	GO:0030168	denotes	platelet activation
T4055	15207-15217	CHEBI:85129	denotes	ristocetin
T4056	15243-15251	CHEBI_EXT:23357	denotes	cofactor
T4057	15341-15349	CL:0000233	denotes	platelet
T4058	15341-15360	GO:0030168	denotes	platelet initiation
T4059	15394-15403	SO_EXT:wild_type_entity	denotes	wild type
T4060	15419-15429	PR_EXT:000004080	denotes	Annexin A7
T4061	15440-15449	CL:0000233	denotes	platelets
T4062	15541-15546	NCBITaxon:9606	denotes	human
T4063	15547-15556	CL:0000233	denotes	platelets
T4064	15609-15619	NCBITaxon:1	denotes	individual
T4065	15627-15648	PR_EXT:000017364	denotes	von Willebrand factor
T4066	15770-15775	NCBITaxon:10088	denotes	mouse
T4067	15776-15785	CL:0000233	denotes	platelets
T4068	15790-15795	PR_EXT:000004080	denotes	anxA7
T4069	15795-15796	SO_EXT:sequence_nullness_or_absence	denotes	-
T4070	15797-15798	SO_EXT:sequence_nullness_or_absence	denotes	-
T4071	15798-15807	CL:0000233	denotes	platelets
T4072	15835-15841	NCBITaxon:39107	denotes	murine
T4073	15842-15851	CL:0000233	denotes	platelets
T4074	15852-15861	GO_EXT:reaction_or_response	denotes	responded
T4075	15892-15900	CHEBI_EXT:chemical_substance_or_polyatomic_entity	denotes	chemical
T4076	15909-15914	NCBITaxon:9606	denotes	human
T4077	15915-15924	CL:0000233	denotes	platelets
T4939	17042-17052	PR_EXT:000004080	denotes	Annexin A7
T4940	17082-17089	GO:0031982	denotes	vesicle
T4941	17082-17096	GO:0006906	denotes	vesicle fusion
T4942	17104-17114	GO:0065007	denotes	regulating
T4943	17131-17147	GO:0044425	denotes	membrane domains
T4944	17157-17164	CHEBI_PR_EXT:protein	denotes	protein
T4945	17191-17206	GO:0005886	denotes	plasma membrane
T4946	17217-17232	GO:0045121	denotes	raft subdomains
T4947	17267-17274	GO:0005829	denotes	cytosol
T4948	17296-17307	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T4949	17299-17307	CL_GO_EXT:cell	denotes	cellular
T4950	17308-17315	GO:0031982	denotes	vesicle
T4951	17384-17390	UBERON:0000479	denotes	tissue
T4952	17394-17398	CL_GO_EXT:cell	denotes	cell
T4953	17443-17457	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T4954	17458-17463	CL_GO_EXT:cell	denotes	cells
T4955	17465-17475	GO:0010467	denotes	expression
T4956	17529-17537	SO_EXT:0001060	denotes	isoforms
T4957	17547-17556	GO:0010467	denotes	expressed
T4958	17568-17583	CL:0000232	denotes	Red blood cells
T4959	17572-17577	UBERON:0000178	denotes	blood
T4960	17578-17583	CL_GO_EXT:cell	denotes	cells
T4961	17620-17630	PR_EXT:000004080	denotes	annexin A7
T4962	17673-17680	SO_EXT:0001060	denotes	isoform
T4963	17699-17706	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T4964	17715-17721	PR_EXT:000015619	denotes	sorcin
T4965	17764-17771	SO_EXT:0001060	denotes	isoform
T4966	17788-17803	CL:0000232	denotes	red blood cells
T4967	17792-17797	UBERON:0000178	denotes	blood
T4968	17798-17803	CL_GO_EXT:cell	denotes	cells
T4969	17819-17824	CL_GO_EXT:cell	denotes	cells
T4970	17842-17849	SO_EXT:0001060	denotes	isoform
T4971	17907-17917	PR_EXT:000004080	denotes	annexin A7
T4972	17921-17936	CL:0000232	denotes	red blood cells
T4973	17925-17930	UBERON:0000178	denotes	blood
T4974	17931-17936	CL_GO_EXT:cell	denotes	cells
T4975	17960-17970	PR_EXT:000004080	denotes	annexin A7
T4976	17975-17981	PR_EXT:000015619	denotes	sorcin
T4977	17999-18020	GO:0045121	denotes	membrane raft domains
T4978	18028-18036	GO:0031982	denotes	vesicles
T4979	18049-18064	CL:0000232	denotes	red blood cells
T4980	18053-18058	UBERON:0000178	denotes	blood
T4981	18059-18064	CL_GO_EXT:cell	denotes	cells
T4982	18075-18087	GO:0045121	denotes	Raft domains
T4983	18129-18137	GO:0016020	denotes	membrane
T4984	18172-18184	GO:0006900	denotes	vesiculation
T4985	18229-18242	CHEBI:26739	denotes	sphingolipids
T4986	18247-18258	CHEBI:16113	denotes	cholesterol
T4987	18272-18282	_FRAGMENT	denotes	leaflet of
T4988	18287-18295	GO:0097478	denotes	membrane
T4989	18309-18322	CHEBI:16247	denotes	phospholipids
T4990	18327-18338	CHEBI:16113	denotes	cholesterol
T4991	18352-18359	GO:0097478	denotes	leaflet
T4992	18388-18396	CHEBI_PR_EXT:protein	denotes	proteins
T4993	18398-18411	CHEBI_EXT:biochemical	denotes	Biochemically
T4994	18412-18417	GO:0045121	denotes	rafts
T4995	18433-18442	GO:0016020	denotes	membranes
T4996	18484-18496	CHEBI:9750	denotes	Triton X-100
T4997	18536-18543	CHEBI:17992	denotes	sucrose
T4998	18614-18624	PR_EXT:000004080	denotes	annexin A7
T4999	18634-18642	GO:0016020	denotes	membrane
T5000	18675-18685	PR_EXT:000004080	denotes	annexin A7
T5001	18719-18731	GO:0006900	denotes	vesiculation
T5002	18787-18799	GO:0006900	denotes	vesiculation
T5003	18811-18814	CHEBI_EXT:GTP	denotes	GTP
T5004	18833-18843	PR_EXT:000004080	denotes	annexin A7
T5005	18854-18860	GO_EXT:0003924	denotes	GTPase
T5006	18889-18892	CHEBI_EXT:GTP	denotes	GTP
T5007	18906-18915	GO_EXT:secretion_entity_or_process	denotes	secretion
T5008	18919-18929	CHEBI_EXT:35195	denotes	surfactant
T5009	18933-18943	PR_EXT:000004080	denotes	annexin A7
T5010	19001-19011	PR_EXT:000004080	denotes	annexin A7
T5011	19015-19025	CHEBI_EXT:35195	denotes	surfactant
T5012	19026-19035	GO_EXT:secretion_entity_or_process	denotes	secretion
T5013	19058-19068	PR_EXT:000004080	denotes	annexin A7
T5014	19078-19086	GO:0016020	denotes	membrane
T5015	19078-19093	GO:0061025	denotes	membrane fusion
T5016	19122-19125	CHEBI_EXT:GTP	denotes	GTP
T5017	19162-19172	PR_EXT:000004080	denotes	annexin A7
T5018	19182-19187	NCBITaxon:10088	denotes	mouse
T5019	19217-19227	PR_EXT:000004080	denotes	annexin A7
T5020	19231-19241	_FRAGMENT	denotes	budding of
T5021	19257-19265	GO:0006900	denotes	vesicles
T5022	19242-19256	CL:0000232	denotes	red blood cell
T5023	19246-19251	UBERON:0000178	denotes	blood
T5024	19252-19256	CL_GO_EXT:cell	denotes	cell
T5025	19257-19265	GO:0031982	denotes	vesicles
T5026	19307-19313	_FRAGMENT	denotes	micro-
T5027	19322-19329	GO:1990742	denotes	vesicle
T5028	19374-19383	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T5029	19388-19394	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5030	19395-19410	CL:0000232	denotes	red blood cells
T5031	19399-19404	UBERON:0000178	denotes	blood
T5032	19405-19410	CL_GO_EXT:cell	denotes	cells
T5033	19422-19446	NCBITaxon:44689	denotes	Dictyostelium discoideum
T5034	19447-19452	CL_GO_EXT:cell	denotes	cells
T5035	19482-19486	SO_EXT:0000704	denotes	gene
T5036	19545-19553	GO:0016020	denotes	membrane
T5037	19545-19560	GO:0061025	denotes	membrane fusion
T5038	19636-19648	CHEBI:16247	denotes	phospholipid
T5039	19659-19669	PR_EXT:000004080	denotes	annexin A7
T5040	19694-19698	CHEBI:29108	denotes	Ca2+
T5041	19786-19796	PR_EXT:000004080	denotes	annexin A7
T5042	19800-19806	_FRAGMENT	denotes	micro-
T5043	19815-19823	GO:1990742	denotes	vesicles
T5044	19879-19893	CL:0000232	denotes	red blood cell
T5045	19883-19888	UBERON:0000178	denotes	blood
T5046	19889-19902	GO:0005886	denotes	cell membrane
T5047	19915-19925	PR_EXT:000004080	denotes	annexin A7
T5048	19946-19950	CHEBI:29108	denotes	Ca2+
T5049	20007-20018	GO:0070382	denotes	exovesicles
T5050	20058-20068	PR_EXT:000004080	denotes	annexin A7
T5051	20069-20077	SO_EXT:0001060	denotes	isoforms
T5052	20094-20109	CL:0000232	denotes	red blood cells
T5053	20098-20103	UBERON:0000178	denotes	blood
T5054	20104-20109	CL_GO_EXT:cell	denotes	cells
T5055	20161-20172	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T5056	20164-20172	CL_GO_EXT:cell	denotes	cellular
T5057	20173-20182	GO:0016020	denotes	membranes
T5058	20186-20194	GO:0016020	denotes	membrane
T5059	20213-20223	PR_EXT:000004075	denotes	annexin A2
T5060	20251-20260	GO:0005768	denotes	endosomes
T5061	20287-20295	GO:0016020	denotes	membrane
T5062	20287-20302	GO:0061025	denotes	membrane fusion
T5063	20311-20320	GO:0005768	denotes	endosomal
T5064	20330-20340	PR_EXT:000004080	denotes	annexin A7
T5065	20358-20386	GO:0044853	denotes	plasma membrane raft domains
T5066	20439-20447	GO:0031982	denotes	vesicles
T5067	20451-20466	CL:0000232	denotes	red blood cells
T5068	20455-20460	UBERON:0000178	denotes	blood
T5069	20461-20466	CL_GO_EXT:cell	denotes	cells
T5070	20475-20485	PR_EXT:000004080	denotes	annexin A7
T5071	20500-20506	PR_EXT:000015619	denotes	sorcin
T5072	20539-20551	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localisation
T5073	20579-20589	PR_EXT:000004080	denotes	annexin A7
T5074	20597-20607	GO:0010467	denotes	expression
T5075	20615-20629	CL:0000232	denotes	red blood cell
T5076	20615-20641	GO:0048821	denotes	red blood cell development
T5077	20619-20624	UBERON:0000178	denotes	blood
T5078	20625-20629	CL_GO_EXT:cell	denotes	cell
T5079	20688-20695	GO:0031982	denotes	vesicle
T5080	20688-20705	GO:0006900	denotes	vesicle formation
T5081	20710-20718	GO:0016020	denotes	membrane
T5082	20710-20725	GO:0061025	denotes	membrane fusion
T5083	20727-20737	PR_EXT:000004080	denotes	annexin A7
T5084	20767-20771	CHEBI:29108	denotes	Ca2+
T5085	20772-20779	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T5086	20780-20787	CHEBI_PR_EXT:protein	denotes	protein
T5087	20820-20830	PR_EXT:000004080	denotes	annexin A7
T5088	20859-20867	GO:0016020	denotes	membrane
T5089	20927-20937	PR_EXT:000004080	denotes	annexin A7
T5090	20975-20979	CHEBI:29108	denotes	Ca2+
T5091	20980-20991	GO:0042592	denotes	homeostasis
T5092	21009-21017	GO:0016020	denotes	membrane
T5093	21076-21100	SO_EXT:biological_conservation_process_or_quality	denotes	evolutionarily conserved
T5094	21101-21108	CHEBI_PR_EXT:protein	denotes	protein
T5095	21210-21217	PR_EXT:annexin	denotes	annexin
T5096	21251-21261	PR_EXT:000004080	denotes	annexin A7
T5097	21286-21301	CL:0000232	denotes	red blood cells
T5098	21290-21295	UBERON:0000178	denotes	blood
T5099	21296-21301	CL_GO_EXT:cell	denotes	cells
T5100	21344-21359	CL:0000232	denotes	red blood cells
T5101	21348-21353	UBERON:0000178	denotes	blood
T5102	21354-21359	CL_GO_EXT:cell	denotes	cells
T5103	21390-21399	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T5104	21417-21432	GO:0005886	denotes	plasma membrane
T5105	21441-21449	GO:0016020	denotes	membrane
T5106	21461-21468	_FRAGMENT	denotes	part of
T5107	21473-21485	GO:0044430	denotes	cytoskeleton
T5108	21521-21529	GO:0016020	denotes	membrane
T5109	21530-21538	GO:0005856	denotes	skeleton
T5110	21543-21551	GO_PR_EXT:spectrin	denotes	spectrin
T5111	21552-21561	GO_EXT:tetrameric_macromolecular_complex	denotes	tetramers
T5112	21587-21602	GO:0005884	denotes	actin filaments
T5113	21621-21629	CHEBI_PR_EXT:protein	denotes	proteins
T5114	21650-21672	_FRAGMENT	denotes	cytoplasmic surface of
T5115	21687-21700	GO:0009898	denotes	cell membrane
T5116	21677-21691	CL:0000232	denotes	red blood cell
T5117	21681-21686	UBERON:0000178	denotes	blood
T5118	21707-21715	GO:0016020	denotes	Membrane
T5119	21716-21727	CHEBI:16113	denotes	cholesterol
T5120	21739-21753	CL:0000232	denotes	red blood cell
T5121	21743-21748	UBERON:0000178	denotes	blood
T5122	21749-21753	CL_GO_EXT:cell	denotes	cell
T5123	21772-21790	GO:0005579	denotes	complement complex
T5124	21813-21817	GO:0045121	denotes	raft
T5125	21818-21829	CHEBI:16113	denotes	cholesterol
T5126	21859-21863	GO:0045121	denotes	raft
T5127	21864-21872	CHEBI_PR_EXT:protein	denotes	proteins
T5128	21928-21932	CL_GO_EXT:cell	denotes	cell
T5129	21928-21941	GO:0005886	denotes	cell membrane
T5130	21969-21979	PR_EXT:000004080	denotes	Annexin A7
T5139	22292-22307	GO:0005886	denotes	plasma membrane
T5140	22381-22385	CHEBI:29108	denotes	Ca2+
T5141	22390-22398	GO:0016020	denotes	membrane
T5142	22399-22407	GO:0005856	denotes	skeletal
T5143	22408-22416	CHEBI_PR_EXT:protein	denotes	proteins
T5144	22452-22466	CL:0000232	denotes	red blood cell
T5145	22456-22461	UBERON:0000178	denotes	blood
T5146	22462-22475	GO:0005886	denotes	cell membrane
T5147	22502-22510	PR_EXT:annexin	denotes	Annexins
T5148	22533-22537	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T5149	22550-22557	GO:0031941	denotes	F-actin
T5150	22605-22615	PR_EXT:000004080	denotes	annexin A7
T5151	22704-22712	GO:0016020	denotes	membrane
T5152	22713-22725	GO:0005856	denotes	cytoskeleton
T5153	22727-22738	GO:0065007	denotes	controlling
T5154	22739-22743	GO:0045121	denotes	raft
T5155	22744-22751	CHEBI_PR_EXT:protein	denotes	protein
T5156	22784-22789	CHEBI:24870	denotes	ionic
T5157	22802-22817	CL:0000232	denotes	red blood cells
T5158	22806-22811	UBERON:0000178	denotes	blood
T5159	22812-22817	CL_GO_EXT:cell	denotes	cells
T5160	22858-22876	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signaling pathways
T5161	22897-22907	PR_EXT:000004080	denotes	annexin A7
T5162	22933-22944	GO:0005737	denotes	cytoplasmic
T5163	22945-22949	CHEBI:29108	denotes	Ca2+
T5164	22950-22961	GO:0042592	denotes	homeostasis
T5165	23019-23032	GO:0005622	denotes	intracellular
T5166	23024-23032	CL_GO_EXT:cell	denotes	cellular
T5167	23033-23037	CHEBI:29108	denotes	Ca2+
T5168	23083-23091	GO:0016020	denotes	membrane
T5169	23108-23116	GO:0065007	denotes	regulate
T5170	23117-23131	CL:0000232	denotes	red blood cell
T5171	23121-23126	UBERON:0000178	denotes	blood
T5172	23127-23131	CL_GO_EXT:cell	denotes	cell
T5173	23172-23185	GO:0005622	denotes	intracellular
T5174	23177-23185	CL_GO_EXT:cell	denotes	cellular
T5175	23186-23190	CHEBI:29108	denotes	Ca2+
T5176	23204-23212	GO:0065007	denotes	regulate
T5177	23217-23225	GO:0016020	denotes	membrane
T5178	23244-23254	GO:0065007	denotes	modulation
T5179	23258-23270	GO:0005856	denotes	cytoskeletal
T5180	23271-23278	CHEBI_PR_EXT:protein	denotes	protein
T5181	23298-23302	CHEBI:29108	denotes	Ca2+
T5182	23331-23343	CHEBI:16247	denotes	phospholipid
T5183	23386-23401	CL:0000232	denotes	red blood cells
T5184	23390-23395	UBERON:0000178	denotes	blood
T5185	23396-23401	CL_GO_EXT:cell	denotes	cells
T5186	23421-23430	CHEBI:29108	denotes	Ca2+ ions
T5187	23460-23468	GO:0016020	denotes	membrane
T5188	23499-23511	GO:0005856	denotes	cytoskeleton
T5189	23552-23560	CL:0000233	denotes	platelet
T5190	23577-23587	PR_EXT:000004080	denotes	annexin A7
T5191	23588-23594	SO_EXT:sequence_altered_entity	denotes	mutant
T5192	23603-23611	CL:0000233	denotes	platelet
T5193	23603-23623	GO:0070527	denotes	platelet aggregation
T5194	23710-23719	CL:0000233	denotes	platelets
T5195	23728-23738	PR_EXT:000004080	denotes	annexin A7
T5196	23823-23831	GO_EXT:reaction_or_response	denotes	reaction
T5197	23841-23847	NCBITaxon:39107	denotes	murine
T5198	23848-23857	CL:0000233	denotes	platelets
T5199	23887-23892	NCBITaxon:9606	denotes	human
T5200	23967-23972	NCBITaxon:10088	denotes	mouse
T5201	23996-24004	GO_EXT:reaction_or_response	denotes	reaction
T5202	24008-24013	NCBITaxon:10088	denotes	mouse
T5203	24014-24023	CL:0000233	denotes	platelets
T5204	24114-24122	CHEBI:9574	denotes	thrombin
T5205	24167-24172	NCBITaxon:9606	denotes	human
T5206	24173-24176	PR_EXT:000017364	denotes	vWF
T5207	24195-24206	GO:0007599	denotes	haemostatic
T5208	24280-24293	GO_PATO_EXT:physiological_process_or_quality	denotes	physiological
T5209	24423-24431	CL:0000233	denotes	platelet
T5210	24452-24460	CL:0000233	denotes	platelet
T5211	24461-24468	CHEBI_EXT:59132	denotes	antigen
T5212	24469-24481	SO_EXT:polymorphism	denotes	polymorphism
T6612	24580-24590	PR_EXT:000004080	denotes	annexin A7
T6613	24591-24599	SO_EXT:0001060	denotes	isoforms
T6614	24603-24618	CL:0000232	denotes	red blood cells
T6615	24607-24612	UBERON:0000178	denotes	blood
T6616	24613-24618	CL_GO_EXT:cell	denotes	cells
T6617	24650-24658	GO:0031982	denotes	vesicles
T6618	24674-24678	CHEBI:29108	denotes	Ca2+
T6619	24693-24701	CHEBI_PR_EXT:protein	denotes	proteins
T6620	24735-24747	GO:0006900	denotes	vesiculation
T6621	24815-24831	GO:0044425	denotes	membrane domains
T6622	24840-24845	CHEBI:18059	denotes	lipid
T6623	24840-24851	GO:0045121	denotes	lipid rafts
T6624	24874-24885	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T6625	24886-24896	PR_EXT:000004080	denotes	annexin A7
T6626	24965-24974	GO:0016020	denotes	membranes
T6627	24988-25003	CL:0000232	denotes	red blood cells
T6628	24992-24997	UBERON:0000178	denotes	blood
T6629	24998-25003	CL_GO_EXT:cell	denotes	cells
T6630	25007-25012	PR_EXT:000004080	denotes	anxA7
T6631	25012-25013	SO_EXT:sequence_nullness_or_absence	denotes	-
T6632	25014-25015	SO_EXT:sequence_nullness_or_absence	denotes	-
T6633	25015-25019	NCBITaxon:10088	denotes	mice
T6634	25034-25038	CL_GO_EXT:cell	denotes	cell
T6635	25055-25067	CL:0000232	denotes	erythrocytes
T6636	25076-25086	PR_EXT:000004080	denotes	annexin A7
T6637	25122-25133	CL:0000232	denotes	erythrocyte
T6638	25134-25146	GO:0005856	denotes	cytoskeleton
T6639	25177-25184	GO:0031941	denotes	F-actin
T6640	25233-25240	PR_EXT:annexin	denotes	annexin
T6641	25243-25247	CHEBI:29108	denotes	Ca2+
T6642	25248-25255	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T6833	25291-25297	NCBITaxon:39107	denotes	murine
T6834	25302-25307	NCBITaxon:9606	denotes	human
T6835	25308-25313	UBERON:0000178	denotes	blood
T6836	25322-25327	UBERON:0000178	denotes	Blood
T6837	25339-25348	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T6838	25353-25363	PR_EXT:000004080	denotes	annexin A7
T6839	25374-25378	NCBITaxon:10088	denotes	mice
T6840	25380-25385	PR_EXT:000004080	denotes	anxA7
T6841	25385-25386	SO_EXT:sequence_nullness_or_absence	denotes	-
T6842	25387-25388	SO_EXT:sequence_nullness_or_absence	denotes	-
T6843	25430-25433	GO:0007631	denotes	fed
T6844	25447-25451	CHEBI_EXT:33290	denotes	food
T6845	25522-25545	UBERON:0002080	denotes	right cardiac ventricle
T6846	25578-25584	GO_EXT:killing	denotes	killed
T6847	25588-25596	UBERON:0005434	denotes	cervical
T6848	25610-25621	GO:0050817	denotes	Coagulation
T6849	25672-25678	CHEBI_EXT:EDTA_sodium_salt	denotes	NaEDTA
T6850	25724-25728	NCBITaxon:10088	denotes	mice
T6851	25734-25740	GO_EXT:killing	denotes	killed
T6852	25744-25752	UBERON:0005434	denotes	cervical
T6853	25797-25818	CHEBI_EXT:38867	denotes	anaesthetic chemicals
T6854	25822-25827	UBERON:0000178	denotes	blood
T6855	25844-25853	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T6856	25858-25864	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T6857	25865-25869	NCBITaxon:10088	denotes	mice
T6858	25935-25940	UBERON:0000178	denotes	blood
T6859	26042-26048	NCBITaxon:39107	denotes	murine
T6860	26049-26054	UBERON:0000178	denotes	blood
T6861	26137-26142	NCBITaxon:9606	denotes	Human
T6862	26143-26148	UBERON:0000178	denotes	blood
T6863	26192-26196	UBERON:0001638	denotes	vein
T6864	26219-26223	CHEBI_EXT:EDTA	denotes	EDTA
T6865	26339-26344	UBERON:0000178	denotes	blood
T6866	26380-26384	UBERON:0002415	denotes	tail
T6867	26389-26394	UBERON:0000948	denotes	heart
T6868	26422-26426	CL_GO_EXT:cell	denotes	cell
T6869	26476-26481	UBERON:0000178	denotes	blood
T6870	26515-26522	SO_EXT:0000704	denotes	genetic
T6871	26559-26569	SO_EXT:transgenic_entity	denotes	transgenic
T6872	26570-26574	NCBITaxon:10088	denotes	mice
T6873	26646-26650	NCBITaxon:10088	denotes	mice
T6874	26689-26696	SO_EXT:0000704	denotes	genetic
T6875	26725-26729	NCBITaxon:10088	denotes	mice
T6876	26773-26781	CL:0000233	denotes	platelet
T6877	26773-26793	GO:0070527	denotes	platelet aggregation
T6878	26815-26819	NCBITaxon:10088	denotes	mice
T7234	26879-26888	CHEBI:31705	denotes	iodixanol
T7235	26910-26915	NCBITaxon:9606	denotes	human
T7236	26916-26931	CL:0000232	denotes	red blood cells
T7237	26920-26925	UBERON:0000178	denotes	blood
T7238	26926-26931	CL_GO_EXT:cell	denotes	cells
T7239	26936-26947	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T7240	26939-26947	CL_GO_EXT:cell	denotes	cellular
T7241	26964-26974	PR_EXT:000004080	denotes	annexin A7
T7242	27008-27023	CL:0000232	denotes	Red blood cells
T7243	27012-27017	UBERON:0000178	denotes	blood
T7244	27018-27023	CL_GO_EXT:cell	denotes	cells
T7245	27064-27072	CHEBI_CHMO_EXT:buffer_process	denotes	buffered
T7246	27073-27086	CHEBI_EXT:saline_solution	denotes	salt solution
T7247	27110-27115	GO:0019835	denotes	lysis
T7248	27116-27122	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T7249	27130-27135	CHEBI:46756	denotes	Hepes
T7250	27152-27157	CHEBI:3312	denotes	CaCl2
T7251	27166-27173	CHEBI:17992	denotes	sucrose
T7252	27179-27200	CHEBI_GO_EXT:peptidase_or_protease_or_proteinase_inhibitor	denotes	proteinase inhibitors
T7253	27278-27286	GO_EXT:biological_movement_or_translocation_process	denotes	passages
T7254	27321-27330	CHEBI:31705	denotes	iodixanol
T7255	27331-27339	CHEBI:75958	denotes	solution
T7256	27375-27383	CHEBI:75958	denotes	solution
T7257	27390-27399	CHEBI:31705	denotes	iodixanol
T7258	27413-27419	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T7259	27428-27433	CHEBI:46756	denotes	Hepes
T7260	27450-27455	CHEBI:3312	denotes	CaCl2
T7261	27464-27471	CHEBI:17992	denotes	sucrose
T7262	27499-27508	CHEBI:31705	denotes	iodixanol
T7263	27509-27517	CHEBI:75958	denotes	solution
T7264	27556-27570	CL:0000232	denotes	red blood cell
T7265	27560-27565	UBERON:0000178	denotes	blood
T7266	27566-27570	CL_GO_EXT:cell	denotes	cell
T7267	27571-27579	CHEBI:75958	denotes	solution
T7268	27603-27611	CHEBI:75958	denotes	solution
T7269	27630-27639	CHEBI:31705	denotes	iodixanol
T7270	27645-27652	CHEBI:60004	denotes	mixture
T7271	27727-27736	CHEBI:31705	denotes	iodixanol
T7272	28046-28054	CHEBI_EXT:nitrogen	denotes	nitrogen
T7588	28073-28083	GO:0070382	denotes	Exovesicle
T7589	28100-28105	NCBITaxon:9606	denotes	human
T7590	28110-28116	NCBITaxon:39107	denotes	murine
T7591	28117-28132	CL:0000232	denotes	red blood cells
T7592	28121-28126	UBERON:0000178	denotes	blood
T7593	28127-28132	CL_GO_EXT:cell	denotes	cells
T7594	28133-28148	CL:0000232	denotes	Red blood cells
T7595	28137-28142	UBERON:0000178	denotes	blood
T7596	28143-28148	CL_GO_EXT:cell	denotes	cells
T7597	28168-28178	CHEBI_GO_EXT:hemoglobin	denotes	hemoglobin
T7598	28190-28201	GO:0070382	denotes	exovesicles
T7599	28218-28225	GO:0031982	denotes	vesicle
T7600	28218-28235	GO:0006900	denotes	vesicle formation
T7601	28239-28243	CHEBI:29108	denotes	Ca2+
T7602	28271-28278	CHEBI_EXT:lithium	denotes	lithium
T7603	28279-28286	CHEBI:28304	denotes	heparin
T7604	28291-28301	GO:0050817	denotes	coagulated
T7605	28302-28307	UBERON:0000178	denotes	blood
T7606	28371-28383	CL:0000232	denotes	erythrocytes
T7607	28418-28423	CHEBI:46756	denotes	Hepes
T7608	28444-28448	CHEBI:26710	denotes	NaCl
T7609	28458-28464	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T7610	28493-28508	CL:0000232	denotes	red blood cells
T7611	28497-28502	UBERON:0000178	denotes	blood
T7612	28503-28508	CL_GO_EXT:cell	denotes	cells
T7613	28536-28548	GO:0006900	denotes	vesiculation
T7614	28549-28555	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T7615	28563-28568	CHEBI:46756	denotes	Hepes
T7616	28585-28589	CHEBI:26710	denotes	NaCl
T7617	28596-28601	CHEBI:3312	denotes	CaCl2
T7618	28619-28623	CHEBI:29108	denotes	Ca2+
T7619	28624-28633	CHEBI_EXT:24869	denotes	ionophore
T7620	28697-28701	CHEBI_EXT:EDTA	denotes	EDTA
T7621	28719-28727	CHEBI:75958	denotes	solution
T7622	28943-28949	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T7623	29022-29036	CL:0000232	denotes	red blood cell
T7624	29026-29031	UBERON:0000178	denotes	blood
T7625	29032-29036	CL_GO_EXT:cell	denotes	cell
T7626	29037-29050	GO:1990742	denotes	microvesicles
T7627	29211-29217	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T7628	29294-29302	GO:0031982	denotes	vesicles
T7629	29328-29336	GO:0031982	denotes	vesicles
T7630	29354-29367	CHEBI:15355	denotes	acetylcholine
T7631	29354-29376	GO_PR_EXT:acetylcholinesterase	denotes	acetylcholine esterase
T7934	29418-29431	CHEBI:15355	denotes	Acetylcholine
T7935	29418-29440	GO_PR_EXT:acetylcholinesterase	denotes	Acetylcholine esterase
T7936	29465-29479	CL:0000232	denotes	red blood cell
T7937	29469-29474	UBERON:0000178	denotes	blood
T7938	29475-29479	CL_GO_EXT:cell	denotes	cell
T7939	29480-29488	GO:0031982	denotes	vesicles
T7940	29523-29529	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T7941	29537-29542	CHEBI:46756	denotes	Hepes
T7942	29559-29563	CHEBI:26710	denotes	NaCl
T7943	29571-29583	CHEBI:9750	denotes	Triton X-100
T7944	29652-29668	CHEBI:37586	denotes	sodium phosphate
T7945	29669-29675	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T7946	29707-29711	CHEBI:86228	denotes	DTNB
T7947	29713-29748	CHEBI:86228	denotes	5,5'-dithiobis-(2-nitrobenzoic acid
T7948	29760-29776	CHEBI:37586	denotes	sodium phosphate
T7949	29777-29783	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T7950	29835-29838	CHEBI:15377	denotes	H2O
T8103	30038-30053	CL:0000232	denotes	red blood cells
T8104	30042-30047	UBERON:0000178	denotes	blood
T8105	30048-30053	CL_GO_EXT:cell	denotes	cells
T8106	30056-30063	CHEBI:34683	denotes	Na2HPO4
T8107	30064-30071	CHEBI:37585	denotes	NaH2PO4
T8108	30072-30080	CHEBI_CHMO_EXT:buffer_process	denotes	buffered
T8109	30081-30085	CHEBI:26710	denotes	NaCl
T8110	30131-30135	CHEBI:26710	denotes	NaCl
T8111	30277-30285	CHEBI:75958	denotes	solution
T8112	30296-30301	UBERON:0000178	denotes	blood
T8295	30605-30613	CL:0000233	denotes	Platelet
T8296	30605-30625	GO:0070527	denotes	Platelet aggregation
T8297	30656-30662	NCBITaxon:39107	denotes	murine
T8298	30663-30668	UBERON:0000178	denotes	blood
T8299	30745-30756	GO_EXT:biological_movement_or_translocation_process	denotes	transferred
T8300	30782-30790	CL:0000233	denotes	platelet
T8301	30796-30802	UBERON:0001969	denotes	plasma
T8302	30814-30822	CL:0000233	denotes	platelet
T8303	30814-30834	GO:0070527	denotes	platelet aggregation
T8304	31054-31060	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T8305	31067-31072	CHEBI:46756	denotes	Hepes
T8306	31081-31085	CHEBI:26710	denotes	NaCl
T8307	31106-31115	CL:0000233	denotes	platelets
T8308	31131-31139	CL:0000233	denotes	platelet
T8309	31195-31204	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T8310	31219-31225	NCBITaxon:39107	denotes	murine
T8311	31230-31235	NCBITaxon:9606	denotes	human
T8312	31261-31270	CL:0000233	denotes	platelets
T8313	31399-31409	CHEBI:85129	denotes	ristocetin
T8314	31410-31418	CHEBI:75958	denotes	solution
T8315	31497-31504	CHEBI_EXT:33893	denotes	reagent
T8316	31545-31550	NCBITaxon:10088	denotes	mouse
T8317	31555-31560	NCBITaxon:9606	denotes	human
T8318	31561-31570	CL:0000233	denotes	platelets
T8319	31577-31583	NCBITaxon:39107	denotes	murine
T8320	31613-31619	NCBITaxon:33208	denotes	animal
T8321	31633-31638	NCBITaxon:9606	denotes	human
T8322	31639-31644	UBERON:0000178	denotes	blood
T8323	31757-31773	NCBITaxon:9606	denotes	human individual
T8324	32025-32033	CL:0000233	denotes	platelet
T8325	32102-32107	UBERON:0000178	denotes	blood
T8688	32152-32165	GO:0030097	denotes	haematopoetic
T8689	32183-32187	CL_GO_EXT:cell	denotes	cell
T8690	32198-32204	NCBITaxon:39107	denotes	murine
T8691	32209-32214	NCBITaxon:9606	denotes	human
T8692	32215-32220	UBERON:0000178	denotes	blood
T8693	32245-32250	UBERON:0000178	denotes	blood
T8694	32294-32298	CL_GO_EXT:cell	denotes	cell
T8695	32336-32351	CL:0000232	denotes	red blood cells
T8696	32340-32345	UBERON:0000178	denotes	blood
T8697	32346-32351	CL_GO_EXT:cell	denotes	cells
T8698	32356-32365	CL:0000233	denotes	platelets
T8699	32468-32483	CL:0000232	denotes	red blood cells
T8700	32472-32477	UBERON:0000178	denotes	blood
T8701	32478-32483	CL_GO_EXT:cell	denotes	cells
T8702	32488-32497	CL:0000233	denotes	platelets
T8703	32603-32613	CL:0000738	denotes	leucocytes
T8704	32615-32630	CL:0000232	denotes	red blood cells
T8705	32619-32624	UBERON:0000178	denotes	blood
T8706	32625-32630	CL_GO_EXT:cell	denotes	cells
T8707	32632-32643	CHEBI_GO_EXT:hemoglobin	denotes	haemoglobin
T8708	32663-32671	CL_GO_EXT:cell	denotes	cellular
T8709	32685-32693	CL_GO_EXT:cell	denotes	cellular
T8710	32694-32705	CHEBI_GO_EXT:hemoglobin	denotes	haemoglobin
T8711	32712-32720	CL_GO_EXT:cell	denotes	cellular
T8712	32721-32732	CHEBI_GO_EXT:hemoglobin	denotes	haemoglobin
T8713	32748-32756	CL:0000233	denotes	platelet
T8714	32765-32777	CL:0000775	denotes	neutrophiles
T8715	32779-32790	CL:0000542	denotes	lymphocytes
T8716	32792-32801	CL:0000576	denotes	monocytes
T8717	32803-32815	CL:0000771	denotes	eosinophiles
T8718	32817-32827	CL:0000767	denotes	basophiles
T8719	32829-32836	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	Peptide
T8720	32922-32933	GO_SO_EXT:sequence_rearrangement_process	denotes	Recombinant
T8721	32934-32944	PR_EXT:000004080	denotes	annexin A7
T8722	32977-32984	GO:0031941	denotes	F-actin
T8723	32985-32992	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T8724	32996-33007	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T8725	33008-33018	PR_EXT:000004080	denotes	annexin A7
T8726	33047-33050	CHEBI:8984	denotes	SDS
T8727	33176-33186	GO:0042571	denotes	Antibodies
T8728	33213-33221	GO_EXT:biological_direction_or_guidance	denotes	directed
T8729	33230-33235	NCBITaxon:10088	denotes	mouse
T8730	33236-33246	PR_EXT:000004080	denotes	annexin A7
T8731	33252-33258	SO_EXT:0000417	denotes	domain
T8732	33280-33286	NCBITaxon:9986	denotes	rabbit
T8733	33292-33298	PR_EXT:000015619	denotes	sorcin
T8734	33299-33307	GO:0042571	denotes	antibody
T9086	6419-6424	CL_GO_EXT:cell	denotes	cells
T9087	6429-6438	CL:0000233	denotes	platelets
T9088	6454-6461	SO_EXT:0001060	denotes	isoform
T9210	7830-7840	PR_EXT:000004080	denotes	annexin A7
T9211	7845-7851	PR_EXT:000015619	denotes	sorcin
T9212	7855-7866	GO:0070382	denotes	exovesicles
T9213	7880-7895	CL:0000232	denotes	red blood cells
T9214	7884-7889	UBERON:0000178	denotes	blood
T9215	7890-7895	CL_GO_EXT:cell	denotes	cells
T9216	7897-7905	GO:0031982	denotes	Vesicles
T9217	7911-7920	SO_EXT:wild_type_entity	denotes	wild type
T9218	7922-7924	SO_EXT:wild_type_entity	denotes	wt
T9219	7930-7935	PR_EXT:000004080	denotes	anxA7
T9220	7935-7936	SO_EXT:sequence_nullness_or_absence	denotes	-
T9221	7937-7938	SO_EXT:sequence_nullness_or_absence	denotes	-
T9222	7939-7945	SO_EXT:sequence_altered_entity	denotes	mutant
T9223	7971-7975	CHEBI:29108	denotes	Ca2+
T9224	7976-7985	CHEBI_EXT:24869	denotes	ionophore
T9225	8091-8097	PR_EXT:000015619	denotes	sorcin
T9226	8109-8117	GO:0042571	denotes	antibody
T9227	8131-8141	PR_EXT:000004080	denotes	annexin A7
T9228	8146-8152	PR_EXT:000015619	denotes	sorcin
T9229	8178-8186	GO:0031982	denotes	vesicles
T9230	8199-8206	SO_EXT:0001060	denotes	isoform
T9231	8210-8220	PR_EXT:000004080	denotes	annexin A7
T9232	8254-8262	GO:0031982	denotes	vesicles
T9233	8280-8288	GO:0031982	denotes	vesicles
T9234	8330-8343	CHEBI:15355	denotes	acetylcholine
T9235	8330-8352	GO_PR_EXT:acetylcholinesterase	denotes	acetylcholine esterase
T9236	8363-8368	NCBITaxon:9606	denotes	Human
T9237	8369-8384	CL:0000232	denotes	red blood cells
T9238	8373-8378	UBERON:0000178	denotes	blood
T9239	8379-8384	CL_GO_EXT:cell	denotes	cells
T9391	9394-9409	CL:0000232	denotes	red blood cells
T9392	9398-9403	UBERON:0000178	denotes	blood
T9393	9404-9409	CL_GO_EXT:cell	denotes	cells
T9394	9439-9448	CHEBI:31705	denotes	iodixanol
T9395	9617-9623	PR_EXT:000015619	denotes	sorcin
T9396	9635-9643	GO:0042571	denotes	antibody
T9479	10429-10444	CL:0000232	denotes	red blood cells
T9480	10433-10438	UBERON:0000178	denotes	blood
T9481	10439-10444	CL_GO_EXT:cell	denotes	cells
T9482	10450-10455	PR_EXT:000004080	denotes	anxA7
T9483	10455-10456	SO_EXT:sequence_nullness_or_absence	denotes	-
T9484	10457-10458	SO_EXT:sequence_nullness_or_absence	denotes	-
T9485	10459-10465	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9486	10474-10483	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T9487	10484-10488	NCBITaxon:10088	denotes	mice
T9488	10503-10511	CL_GO_EXT:cell	denotes	cellular
T9588	12750-12765	CL:0000232	denotes	red blood cells
T9589	12754-12759	UBERON:0000178	denotes	blood
T9590	12760-12765	CL_GO_EXT:cell	denotes	cells
T9591	12771-12780	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T9592	12785-12790	PR_EXT:000004080	denotes	anxA7
T9593	12790-12791	SO_EXT:sequence_nullness_or_absence	denotes	-
T9594	12792-12793	SO_EXT:sequence_nullness_or_absence	denotes	-
T9595	12794-12800	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9596	12801-12805	NCBITaxon:10088	denotes	mice
T9597	12853-12866	GO:0005576	denotes	extracellular
T9598	12858-12866	CL_GO_EXT:cell	denotes	cellular
T9599	12867-12872	CHEBI:24870	denotes	ionic
T9600	12924-12938	CL:0000232	denotes	red blood cell
T9601	12928-12933	UBERON:0000178	denotes	blood
T9602	12934-12938	CL_GO_EXT:cell	denotes	cell
T9603	12970-12985	CHEBI:26710	denotes	sodium chloride
T9604	13009-13017	CL_GO_EXT:cell	denotes	cellular
T9605	13009-13023	GO:0019835	denotes	cellular lysis
T9606	13069-13074	_FRAGMENT	denotes	lysis
T9607	13096-13098	_FRAGMENT	denotes	of
T9608	13111-13115	GO:0019835	denotes	cell
T9609	13101-13115	CL:0000232	denotes	red blood cell
T9610	13105-13110	UBERON:0000178	denotes	blood
T9611	13111-13115	CL_GO_EXT:cell	denotes	cell
T9612	13143-13153	PR_EXT:000004080	denotes	annexin A7
T9613	13164-13179	CL:0000232	denotes	red blood cells
T9614	13168-13173	UBERON:0000178	denotes	blood
T9615	13174-13179	CL_GO_EXT:cell	denotes	cells
T9616	13230-13239	SO_EXT:wild_type_entity	denotes	wild type
T9758	15958-15966	CL:0000233	denotes	Platelet
T9759	15958-15978	GO:0070527	denotes	Platelet aggregation
T9760	15991-15999	CL:0000233	denotes	platelet
T9761	16005-16011	UBERON:0001969	denotes	plasma
T9762	16015-16025	PR_EXT:000004080	denotes	annexin A7
T9763	16040-16049	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T9764	16050-16054	NCBITaxon:10088	denotes	mice
T9765	16159-16169	CHEBI:85129	denotes	ristocetin
T9766	16216-16224	CL:0000233	denotes	platelet
T9767	16408-16414	NCBITaxon:39107	denotes	murine
T9768	16482-16490	CL:0000233	denotes	platelet
T9769	16482-16501	GO:0030168	denotes	platelet initiation
T9770	16507-16513	SO_EXT:sequence_altered_entity	denotes	mutant
T9771	16591-16600	SO_EXT:wild_type_entity	denotes	wild type
T9772	16650-16659	SO_EXT:wild_type_entity	denotes	wild type
T9773	16745-16754	SO_EXT:wild_type_entity	denotes	wild type
T9774	16779-16785	NCBITaxon:39107	denotes	Murine
T9775	16786-16795	CL:0000233	denotes	platelets
T9776	16796-16801	GO_EXT:reaction_or_response	denotes	react
T9777	16832-16840	CHEBI_EXT:chemical_substance_or_polyatomic_entity	denotes	chemical
T9778	16879-16884	NCBITaxon:9606	denotes	human
T9779	16885-16894	CL:0000233	denotes	platelets
T9780	16931-16939	CL:0000233	denotes	platelet
T9781	16969-16974	NCBITaxon:9606	denotes	human
T9782	16975-16984	CL:0000233	denotes	platelets
T5137	22177-22185	GO:0016020	denotes	membrane
T5138	22241-22251	PR_EXT:000004080	denotes	Annexin A7
T9069	6100-6110	GO:0010467	denotes	Expression
T9070	6114-6124	PR_EXT:000004080	denotes	annexin A7
T9071	6128-6133	NCBITaxon:9606	denotes	human
T9072	6134-6149	CL:0000232	denotes	red blood cells
T9073	6138-6143	UBERON:0000178	denotes	blood
T9074	6144-6149	CL_GO_EXT:cell	denotes	cells
T9075	6158-6163	NCBITaxon:9606	denotes	human
T9076	6164-6173	CL:0000233	denotes	platelets
T9077	6179-6186	CHEBI_PR_EXT:protein	denotes	Protein
T9078	6217-6220	CHEBI:8984	denotes	SDS
T9079	6232-6242	CHEBI:28619	denotes	acrylamide
T9080	6334-6344	GO_EXT:0004601	denotes	peroxidase
T9081	6345-6352	MOP:0000779	denotes	coupled
T9082	6353-6361	GO:0042571	denotes	antibody
T9083	6384-6392	SO_EXT:0001060	denotes	isoforms
T9084	6409-6424	CL:0000232	denotes	red blood cells
T9085	6413-6418	UBERON:0000178	denotes	blood
T9383	9304-9314	PR_EXT:000004080	denotes	annexin A7
T9384	9319-9325	PR_EXT:000015619	denotes	sorcin
T9385	9340-9354	CL:0000232	denotes	red blood cell
T9386	9344-9349	UBERON:0000178	denotes	blood
T9387	9350-9354	CL_GO_EXT:cell	denotes	cell
T9388	9355-9370	GO:0005886	denotes	plasma membrane
T9389	9382-9387	GO:0019835	denotes	Lysed
T9390	9388-9393	NCBITaxon:9606	denotes	human
T2362	5989-5996	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T2363	6046-6053	SO_EXT:0001060	denotes	isoform
T2364	6490-6498	GO:0031982	denotes	vesicles
T2365	6539-6551	GO:0045121	denotes	raft domains
T2366	6553-6563	PR_EXT:000004080	denotes	annexin A7
T2367	6580-6588	GO:0016020	denotes	membrane
T2368	6610-6622	GO:0006900	denotes	vesiculation
T2369	6676-6691	CL:0000232	denotes	red blood cells
T2370	6680-6685	UBERON:0000178	denotes	blood
T2371	6686-6691	CL_GO_EXT:cell	denotes	cells
T2372	6709-6719	PR_EXT:000004080	denotes	annexin A7
T2373	6730-6734	NCBITaxon:10088	denotes	mice
T2374	6736-6741	PR_EXT:000004080	denotes	anxA7
T2375	6741-6742	SO_EXT:sequence_nullness_or_absence	denotes	-
T2376	6743-6744	SO_EXT:sequence_nullness_or_absence	denotes	-
T2377	6754-6765	GO:0070382	denotes	exovesicles
T2378	6890-6895	NCBITaxon:9606	denotes	human
T2379	6896-6901	UBERON:0000178	denotes	blood
T2380	6934-6944	PR_EXT:000004080	denotes	annexin A7
T2381	6959-6970	GO:0070382	denotes	exovesicles
T2382	6972-6978	_FRAGMENT	denotes	micro-
T2383	6987-6995	GO:1990742	denotes	vesicles
T2384	7002-7010	GO_EXT:biological_release	denotes	released
T2385	7017-7021	CHEBI:29108	denotes	Ca2+
T2386	7022-7031	CHEBI_EXT:24869	denotes	ionophore
T2387	7059-7072	CHEBI:15355	denotes	acetylcholine
T2388	7059-7081	GO_PR_EXT:acetylcholinesterase	denotes	acetylcholine esterase
T2389	7120-7130	PR_EXT:000004080	denotes	Annexin A7
T2390	7150-7157	GO:0031982	denotes	vesicle
T2391	7197-7205	GO:0031982	denotes	vesicles
T2392	7227-7234	SO_EXT:0001060	denotes	isoform
T2393	7261-7269	GO:0031982	denotes	vesicles
T2394	7292-7299	GO:0031982	denotes	vesicle
T2396	7353-7367	CL:0000232	denotes	red blood cell
T2417	8471-8481	PR_EXT:000004080	denotes	annexin A7
T2418	8485-8500	CL:0000232	denotes	red blood cells
T2419	8489-8494	UBERON:0000178	denotes	blood
T2420	8495-8500	CL_GO_EXT:cell	denotes	cells
T2421	8522-8531	CHEBI:31705	denotes	iodixanol
T2422	8556-8564	SO_EXT:0001060	denotes	isoforms
T2423	8684-8693	GO:0016020	denotes	membranes
T2424	8701-8710	GO:0016020	denotes	membranes
T2425	8727-8743	GO:0005886	denotes	plasma membranes
T2426	8747-8762	CL:0000232	denotes	red blood cells
T2427	8751-8756	UBERON:0000178	denotes	blood
T2428	8757-8762	CL_GO_EXT:cell	denotes	cells
T2429	8779-8789	GO:0043226	denotes	organelles
T2430	8884-8891	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T2431	8895-8905	PR_EXT:000004080	denotes	annexin A7
T2432	8909-8928	GO:0044425	denotes	membrane subdomains
T2433	8949-8954	CHEBI:18059	denotes	lipid
T2434	8958-8963	CHEBI:18059	denotes	lipid
T2435	8964-8971	CHEBI_PR_EXT:protein	denotes	protein
T2436	9029-9035	PR_EXT:000015619	denotes	sorcin
T2437	9126-9134	GO:0031982	denotes	vesicles
T2438	9165-9175	PR_EXT:000004080	denotes	annexin A7
T2439	9201-9210	CL:0000233	denotes	platelets
T2440	9215-9225	PR_EXT:000004080	denotes	annexin A7
T2441	9226-9236	GO:0010467	denotes	expression
T2442	9261-9268	SO_EXT:0001060	denotes	isoform
T3173	9658-9668	PR_EXT:000004080	denotes	annexin A7
T3174	9677-9691	CL:0000232	denotes	red blood cell
T3208	10843-10853	GO:0016020	denotes	membranous
T3209	10854-10866	GO:0005856	denotes	cytoskeleton
T3210	10878-10888	PR_EXT:000004080	denotes	annexin A7
T3211	10979-10992	GO:0005576	denotes	extracellular
T3212	10984-10992	CL_GO_EXT:cell	denotes	cellular
T3213	10993-10998	CHEBI:24870	denotes	ionic
T3214	11051-11065	CL:0000232	denotes	red blood cell
T3215	11055-11060	UBERON:0000178	denotes	blood
T3216	11061-11065	CL_GO_EXT:cell	denotes	cell
T3217	11099-11114	CHEBI:26710	denotes	sodium chloride
T3218	11138-11146	CL_GO_EXT:cell	denotes	cellular
T3219	11138-11152	GO:0019835	denotes	cellular lysis
T3220	11198-11203	_FRAGMENT	denotes	lysis
T3221	11225-11227	_FRAGMENT	denotes	of
T3222	11232-11237	GO:0019835	denotes	cells
T3223	11232-11237	CL_GO_EXT:cell	denotes	cells
T3224	11297-11304	GO:0009986	denotes	surface
T3225	11333-11341	CL_GO_EXT:cell	denotes	cellular
T3226	11333-11352	GO:0044237	denotes	cellular metabolism
T3227	11369-11382	GO:0005622	denotes	intracellular
T3228	11374-11382	CL_GO_EXT:cell	denotes	cellular
T3229	11383-11386	CHEBI:24870	denotes	ion
T3230	11395-11399	GO_PATO_EXT:aging_or_agedness	denotes	Aged
T3231	11400-11415	CL:0000232	denotes	red blood cells
T3232	11404-11409	UBERON:0000178	denotes	blood
T3233	11410-11415	CL_GO_EXT:cell	denotes	cells
T3234	11508-11523	CL:0000232	denotes	red blood cells
T3235	11512-11517	UBERON:0000178	denotes	blood
T3236	11518-11523	CL_GO_EXT:cell	denotes	cells
T3237	11537-11545	GO:0016020	denotes	membrane
T894	11-21	PR_EXT:000004080	denotes	Annexin A7
T5131	21990-21995	NCBITaxon:10088	denotes	mouse
T5132	21996-22011	CL:0000232	denotes	red blood cells
T5133	22000-22005	UBERON:0000178	denotes	blood
T5134	22006-22011	CL_GO_EXT:cell	denotes	cells
T5135	22089-22099	PR_EXT:000004080	denotes	annexin A7
T5136	22114-22122	GO:0016020	denotes	membrane
R2761	T5021	T5020	_lexicallyChainedTo	vesicles,budding of
R2762	T5027	T5026	_lexicallyChainedTo	vesicle,micro-
R2763	T5043	T5042	_lexicallyChainedTo	vesicles,micro-
R2764	T5107	T5106	_lexicallyChainedTo	cytoskeleton,part of
R2765	T5115	T5114	_lexicallyChainedTo	cell membrane,cytoplasmic surface of
R6012	T9607	T9606	_lexicallyChainedTo	of,lysis
R6013	T9608	T9607	_lexicallyChainedTo	cell,of
R310	T901	T900	_lexicallyChainedTo	membranes,fusion of
R311	T959	T958	_lexicallyChainedTo	membrane,plasma
R312	T1085	T1084	_lexicallyChainedTo	exovesicles,release of
R313	T1101	T1100	_lexicallyChainedTo	vesicles,micro-
R1262	T2347	T2346	_lexicallyChainedTo	vesicles,micro-
R1263	T2383	T2382	_lexicallyChainedTo	vesicles,micro-
R1793	T3221	T3220	_lexicallyChainedTo	of,lysis
R1794	T3222	T3221	_lexicallyChainedTo	cells,of
R2760	T4988	T4987	_lexicallyChainedTo	membrane,leaflet of

PMC:194730 / 1832-36179 JSONTXT

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craft-sa-dev

craft-ca-core-dev

2_test

craft-ca-core-ex-dev

PMC:194730 / 1832-36179 JSON TXT