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Both isoforms were present in the soluble fraction as well as in the gradient fractions where they are assumed to be associated with membranes. These membranes are exclusively plasma membranes as red blood cells are free of any organelles. The distribution was however not homogeneous throughout the gradient. This could reflect the binding of annexin A7 to membrane subdomains that have different lipid or lipid/protein composition as discussed by Salzer et al. [7]. Likewise, sorcin does not exhibit a homogeneous distribution in the gradient. Moreover, it segregates into vesicles which are not associated with annexin A7 (Fig. 3). We also tested platelets for annexin A7 expression and detected the 47 kDa isoform (Fig. 1)."}

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{"project":"2_test","denotations":[{"id":"12925238-11895795-8102398","span":{"begin":573,"end":574},"obj":"11895795"}],"text":"To study the distribution of annexin A7 in red blood cells we used self forming iodixanol density gradients. Both isoforms were present in the soluble fraction as well as in the gradient fractions where they are assumed to be associated with membranes. These membranes are exclusively plasma membranes as red blood cells are free of any organelles. The distribution was however not homogeneous throughout the gradient. This could reflect the binding of annexin A7 to membrane subdomains that have different lipid or lipid/protein composition as discussed by Salzer et al. [7]. Likewise, sorcin does not exhibit a homogeneous distribution in the gradient. Moreover, it segregates into vesicles which are not associated with annexin A7 (Fig. 3). We also tested platelets for annexin A7 expression and detected the 47 kDa isoform (Fig. 1)."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T2417","span":{"begin":29,"end":39},"obj":"PR_EXT:000004080"},{"id":"T2418","span":{"begin":43,"end":58},"obj":"CL:0000232"},{"id":"T2419","span":{"begin":47,"end":52},"obj":"UBERON:0000178"},{"id":"T2420","span":{"begin":53,"end":58},"obj":"CL_GO_EXT:cell"},{"id":"T2421","span":{"begin":80,"end":89},"obj":"CHEBI:31705"},{"id":"T2422","span":{"begin":114,"end":122},"obj":"SO_EXT:0001060"},{"id":"T2423","span":{"begin":242,"end":251},"obj":"GO:0016020"},{"id":"T2424","span":{"begin":259,"end":268},"obj":"GO:0016020"},{"id":"T2425","span":{"begin":285,"end":301},"obj":"GO:0005886"},{"id":"T2426","span":{"begin":305,"end":320},"obj":"CL:0000232"},{"id":"T2427","span":{"begin":309,"end":314},"obj":"UBERON:0000178"},{"id":"T2428","span":{"begin":315,"end":320},"obj":"CL_GO_EXT:cell"},{"id":"T2429","span":{"begin":337,"end":347},"obj":"GO:0043226"},{"id":"T2430","span":{"begin":442,"end":449},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T2431","span":{"begin":453,"end":463},"obj":"PR_EXT:000004080"},{"id":"T2432","span":{"begin":467,"end":486},"obj":"GO:0044425"},{"id":"T2433","span":{"begin":507,"end":512},"obj":"CHEBI:18059"},{"id":"T2434","span":{"begin":516,"end":521},"obj":"CHEBI:18059"},{"id":"T2435","span":{"begin":522,"end":529},"obj":"CHEBI_PR_EXT:protein"},{"id":"T2436","span":{"begin":587,"end":593},"obj":"PR_EXT:000015619"},{"id":"T2437","span":{"begin":684,"end":692},"obj":"GO:0031982"},{"id":"T2438","span":{"begin":723,"end":733},"obj":"PR_EXT:000004080"},{"id":"T2439","span":{"begin":759,"end":768},"obj":"CL:0000233"},{"id":"T2440","span":{"begin":773,"end":783},"obj":"PR_EXT:000004080"},{"id":"T2441","span":{"begin":784,"end":794},"obj":"GO:0010467"},{"id":"T2442","span":{"begin":819,"end":826},"obj":"SO_EXT:0001060"}],"text":"To study the distribution of annexin A7 in red blood cells we used self forming iodixanol density gradients. Both isoforms were present in the soluble fraction as well as in the gradient fractions where they are assumed to be associated with membranes. These membranes are exclusively plasma membranes as red blood cells are free of any organelles. The distribution was however not homogeneous throughout the gradient. This could reflect the binding of annexin A7 to membrane subdomains that have different lipid or lipid/protein composition as discussed by Salzer et al. [7]. Likewise, sorcin does not exhibit a homogeneous distribution in the gradient. Moreover, it segregates into vesicles which are not associated with annexin A7 (Fig. 3). We also tested platelets for annexin A7 expression and detected the 47 kDa isoform (Fig. 1)."}