PMC:1942070 / 8937-13150 JSON TXT

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2_test

Id	Subject	Object	Predicate	Lexical cue
17349631-16006559-30580540	1457-1459	16006559	denotes	35
17349631-14963034-30580540	1457-1459	14963034	denotes	35
17349631-8995387-30580541	2000-2002	8995387	denotes	36
17349631-12505989-30580542	3343-3345	12505989	denotes	37
17349631-15604256-30580542	3343-3345	15604256	denotes	37
17349631-16166634-30580542	3343-3345	16166634	denotes	37
17349631-15024053-30580542	3343-3345	15024053	denotes	37
17349631-15743830-30580543	3440-3442	15743830	denotes	38
17349631-16356855-30580544	3508-3510	16356855	denotes	40
17349631-16301747-30580544	3508-3510	16301747	denotes	40

MyTest

Id	Subject	Object	Predicate	Lexical cue
17349631-16006559-30580540	1457-1459	16006559	denotes	35
17349631-14963034-30580540	1457-1459	14963034	denotes	35
17349631-8995387-30580541	2000-2002	8995387	denotes	36
17349631-12505989-30580542	3343-3345	12505989	denotes	37
17349631-15604256-30580542	3343-3345	15604256	denotes	37
17349631-16166634-30580542	3343-3345	16166634	denotes	37
17349631-15024053-30580542	3343-3345	15024053	denotes	37
17349631-15743830-30580543	3440-3442	15743830	denotes	38
17349631-16356855-30580544	3508-3510	16356855	denotes	40
17349631-16301747-30580544	3508-3510	16301747	denotes	40

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T5032	13-21	NN	denotes	receptor
T5033	22-31	VB	denotes	regulated
T5034	32-42	NN	denotes	signalling
T5035	43-51	NN	denotes	pathways
T5036	52-54	IN	denotes	in
T5037	55-63	JJ	denotes	PKD-null
T5038	64-68	NN	denotes	DT40
T5039	69-70	NN	denotes	B
T5040	71-76	NN	denotes	cells
T5041	77-79	TO	denotes	To
T5042	80-87	RB	denotes	further
T5043	88-95	VB	denotes	explore
T5044	96-99	DT	denotes	the
T5045	100-112	NN	denotes	contribution
T5046	113-115	IN	denotes	of
T5047	116-119	NN	denotes	PKD
T5048	120-127	NN	denotes	kinases
T5049	128-130	TO	denotes	to
T5050	131-135	NN	denotes	DT40
T5051	136-137	NN	denotes	B
T5052	138-142	NN	denotes	cell
T5053	143-150	NN	denotes	biology
T5054	151-153	PRP	denotes	we
T5055	154-166	VB	denotes	investigated
T5056	167-174	IN	denotes	whether
T5057	175-183	JJ	denotes	specific
T5058	184-197	JJ	denotes	BCR-regulated
T5059	198-208	NN	denotes	signalling
T5060	209-215	NN	denotes	events
T5061	216-220	VB	denotes	were
T5062	221-230	JJ	denotes	defective
T5063	231-233	IN	denotes	in
T5064	234-237	DT	denotes	the
T5065	238-246	JJ	denotes	PKD-null
T5066	247-248	NN	denotes	B
T5067	249-254	NN	denotes	cells
T5068	256-263	JJ	denotes	Initial
T5069	264-275	NN	denotes	experiments
T5070	276-284	VB	denotes	revealed
T5071	285-289	IN	denotes	that
T5072	290-297	NN	denotes	surface
T5073	298-308	NN	denotes	expression
T5074	309-311	IN	denotes	of
T5075	312-315	DT	denotes	the
T5076	316-319	NN	denotes	BCR
T5077	320-323	VB	denotes	was
T5078	324-331	VB	denotes	reduced
T5079	332-334	IN	denotes	in
T5080	335-344	NN	denotes	PKD1/3−/−
T5081	345-346	-LRB-	denotes	(
T5082	346-349	CC	denotes	and
T5083	350-352	IN	denotes	in
T5084	353-362	NN	denotes	PKD1/3−/−
T5085	362-363	-COLON-	denotes	:
T5086	363-375	NN	denotes	Flag-PKD3+ve
T5087	375-376	-RRB-	denotes	)
T5088	377-382	NN	denotes	cells
T5089	383-391	VB	denotes	compared
T5090	392-394	TO	denotes	to
T5091	395-404	JJ	denotes	wild-type
T5092	405-409	NN	denotes	DT40
T5093	410-411	NN	denotes	B
T5094	412-417	NN	denotes	cells
T5095	418-419	-LRB-	denotes	(
T5096	419-423	NN	denotes	Fig.
T5097	424-426	NN	denotes	3A
T5098	427-430	CC	denotes	and
T5099	431-435	NN	denotes	data
T5100	436-439	RB	denotes	not
T5101	440-445	VB	denotes	shown
T5102	445-446	-RRB-	denotes	)
T5103	448-460	RB	denotes	Nevertheless
T5104	460-461	-COMMA-	denotes	,
T5105	462-478	NN	denotes	BCR-crosslinking
T5106	479-481	IN	denotes	of
T5107	482-491	NN	denotes	PKD1/3−/−
T5108	492-497	NN	denotes	cells
T5109	498-501	VB	denotes	was
T5110	502-512	JJ	denotes	sufficient
T5111	513-515	TO	denotes	to
T5112	516-522	VB	denotes	induce
T5113	523-526	DT	denotes	the
T5114	527-537	NN	denotes	activation
T5115	538-540	IN	denotes	of
T5116	541-542	DT	denotes	a
T5117	543-549	NN	denotes	number
T5118	550-552	IN	denotes	of
T5119	553-563	NN	denotes	signalling
T5120	564-572	NN	denotes	cascades
T5121	572-573	-COMMA-	denotes	,
T5122	574-581	JJ	denotes	similar
T5123	582-584	TO	denotes	to
T5124	585-589	DT	denotes	that
T5125	590-598	VB	denotes	observed
T5126	599-601	IN	denotes	in
T5127	602-611	JJ	denotes	wild-type
T5128	612-617	NN	denotes	cells
T5129	618-619	-LRB-	denotes	(
T5130	619-623	NN	denotes	Fig.
T5131	624-626	NN	denotes	3B
T5132	626-627	-RRB-	denotes	)
T5133	629-634	RB	denotes	Hence
T5134	634-635	-COMMA-	denotes	,
T5135	636-647	JJ	denotes	BCR-induced
T5136	648-658	NN	denotes	activation
T5137	659-661	IN	denotes	of
T5138	662-665	DT	denotes	the
T5139	666-669	NN	denotes	Akt
T5140	669-670	-COMMA-	denotes	,
T5141	671-679	NN	denotes	mTOR/p70
T5142	680-682	NN	denotes	S6
T5143	683-689	NN	denotes	kinase
T5144	690-691	-LRB-	denotes	(
T5145	691-693	IN	denotes	as
T5146	694-699	VB	denotes	shown
T5147	700-702	IN	denotes	by
T5148	703-705	NN	denotes	S6
T5149	706-715	JJ	denotes	ribosomal
T5150	716-723	NN	denotes	protein
T5151	724-739	NN	denotes	phosphorylation
T5152	739-740	-RRB-	denotes	)
T5153	741-744	CC	denotes	and
T5154	745-749	NN	denotes	MAPK
T5155	750-760	NN	denotes	signalling
T5156	761-769	NN	denotes	pathways
T5157	770-773	VB	denotes	was
T5158	774-781	RB	denotes	clearly
T5159	782-792	JJ	denotes	detectable
T5160	793-795	IN	denotes	in
T5161	796-807	JJ	denotes	PKD1/3-null
T5162	808-809	NN	denotes	B
T5163	810-815	NN	denotes	cells
T5164	816-817	-LRB-	denotes	(
T5165	817-821	NN	denotes	Fig.
T5166	822-824	NN	denotes	3B
T5167	824-825	-RRB-	denotes	)
T5168	827-838	RB	denotes	Furthermore
T5169	838-839	-COMMA-	denotes	,
T5170	840-848	VB	denotes	enhanced
T5171	849-857	NN	denotes	tyrosine
T5172	858-873	NN	denotes	phosphorylation
T5173	874-876	IN	denotes	of
T5174	877-885	JJ	denotes	multiple
T5175	886-894	JJ	denotes	cellular
T5176	895-903	NN	denotes	proteins
T5177	904-906	RB	denotes	as
T5178	907-911	RB	denotes	well
T5179	912-914	IN	denotes	as
T5180	915-917	DT	denotes	an
T5181	918-926	NN	denotes	increase
T5182	927-929	IN	denotes	in
T5183	930-943	JJ	denotes	intracellular
T5184	944-951	NN	denotes	calcium
T5185	952-958	NN	denotes	levels
T5186	959-962	VB	denotes	was
T5187	963-967	RB	denotes	also
T5188	968-976	VB	denotes	observed
T5189	977-986	VB	denotes	following
T5190	987-990	NN	denotes	BCR
T5191	991-1002	NN	denotes	stimulation
T5192	1003-1005	IN	denotes	of
T5193	1006-1017	JJ	denotes	PKD1/3-null
T5194	1018-1019	NN	denotes	B
T5195	1020-1025	NN	denotes	cells
T5196	1026-1027	-LRB-	denotes	(
T5197	1027-1031	NN	denotes	data
T5198	1032-1035	RB	denotes	not
T5199	1036-1041	VB	denotes	shown
T5200	1041-1042	-RRB-	denotes	)
T5201	1044-1046	PRP	denotes	We
T5202	1047-1050	VB	denotes	did
T5203	1051-1058	VB	denotes	observe
T5204	1059-1063	IN	denotes	that
T5205	1064-1067	DT	denotes	the
T5206	1068-1076	NN	denotes	strength
T5207	1077-1079	IN	denotes	of
T5208	1080-1083	NN	denotes	BCR
T5209	1084-1085	-LRB-	denotes	(
T5210	1085-1088	CC	denotes	but
T5211	1089-1092	RB	denotes	not
T5212	1093-1100	NN	denotes	phorbol
T5213	1101-1106	NN	denotes	ester
T5214	1106-1107	-RRB-	denotes	)
T5215	1107-1115	JJ	denotes	-induced
T5216	1116-1126	NN	denotes	regulation
T5217	1127-1129	IN	denotes	of
T5218	1130-1133	DT	denotes	the
T5219	1134-1143	NN	denotes	Erk1-RSK1
T5220	1144-1154	NN	denotes	signalling
T5221	1155-1162	NN	denotes	pathway
T5222	1163-1166	VB	denotes	was
T5223	1167-1174	VB	denotes	reduced
T5224	1175-1177	IN	denotes	in
T5225	1178-1187	NN	denotes	PKD1/3−/−
T5226	1188-1189	NN	denotes	B
T5227	1190-1195	NN	denotes	cells
T5228	1196-1204	VB	denotes	compared
T5229	1205-1207	TO	denotes	to
T5230	1208-1217	JJ	denotes	wild-type
T5231	1218-1219	NN	denotes	B
T5232	1220-1225	NN	denotes	cells
T5233	1226-1227	-LRB-	denotes	(
T5234	1227-1231	NN	denotes	Fig.
T5235	1232-1234	NN	denotes	3B
T5236	1234-1235	-RRB-	denotes	)
T5237	1237-1240	CD	denotes	One
T5238	1241-1255	NN	denotes	interpretation
T5239	1256-1258	IN	denotes	of
T5240	1259-1263	DT	denotes	this
T5241	1264-1268	NN	denotes	data
T5242	1269-1271	VB	denotes	is
T5243	1272-1276	IN	denotes	that
T5244	1277-1280	NN	denotes	PKD
T5245	1281-1288	NN	denotes	enzymes
T5246	1289-1292	MD	denotes	may
T5247	1293-1301	VB	denotes	modulate
T5248	1302-1305	NN	denotes	Erk
T5249	1306-1316	NN	denotes	activation
T5250	1318-1324	RB	denotes	Indeed
T5251	1324-1325	-COMMA-	denotes	,
T5252	1326-1329	NN	denotes	PKD
T5253	1330-1337	NN	denotes	enzymes
T5254	1338-1342	VB	denotes	have
T5255	1343-1353	RB	denotes	previously
T5256	1354-1358	VB	denotes	been
T5257	1359-1365	VB	denotes	linked
T5258	1366-1368	TO	denotes	to
T5259	1369-1372	DT	denotes	the
T5260	1373-1379	NN	denotes	growth
T5261	1380-1396	JJ	denotes	factor-regulated
T5262	1397-1400	NN	denotes	Erk
T5263	1401-1411	NN	denotes	signalling
T5264	1412-1414	IN	denotes	in
T5265	1415-1425	NN	denotes	fibroblast
T5266	1426-1429	CC	denotes	and
T5267	1430-1441	JJ	denotes	endothelial
T5268	1442-1446	NN	denotes	cell
T5269	1447-1452	NN	denotes	lines
T5270	1453-1454	-LRB-	denotes	[
T5271	1454-1459	CD	denotes	33–35
T5272	1459-1460	-RRB-	denotes	]
T5273	1462-1469	RB	denotes	However
T5274	1469-1470	-COMMA-	denotes	,
T5275	1471-1482	JJ	denotes	BCR-induced
T5276	1483-1486	NN	denotes	Erk
T5277	1487-1502	NN	denotes	phosphorylation
T5278	1503-1506	VB	denotes	was
T5279	1507-1511	RB	denotes	also
T5280	1512-1519	VB	denotes	reduced
T5281	1520-1522	IN	denotes	in
T5282	1523-1543	JJ	denotes	PKD1/3−/−-Flag-PKD3+
T5283	1544-1545	NN	denotes	B
T5284	1546-1551	NN	denotes	cells
T5285	1552-1553	-LRB-	denotes	(
T5286	1553-1557	NN	denotes	data
T5287	1558-1561	RB	denotes	not
T5288	1562-1567	VB	denotes	shown
T5289	1567-1568	-RRB-	denotes	)
T5290	1569-1579	VB	denotes	suggesting
T5291	1580-1584	IN	denotes	that
T5292	1585-1592	VB	denotes	reduced
T5293	1593-1596	NN	denotes	BCR
T5294	1597-1603	NN	denotes	levels
T5295	1604-1606	IN	denotes	on
T5296	1607-1610	DT	denotes	the
T5297	1611-1618	NN	denotes	surface
T5298	1619-1621	IN	denotes	of
T5299	1622-1631	NN	denotes	PKD1/3−/−
T5300	1632-1633	-LRB-	denotes	(
T5301	1633-1636	CC	denotes	and
T5302	1637-1657	JJ	denotes	PKD1/3−/−-Flag-PKD3+
T5303	1657-1658	-RRB-	denotes	)
T5304	1659-1660	NN	denotes	B
T5305	1661-1666	NN	denotes	cells
T5306	1667-1670	MD	denotes	may
T5307	1671-1677	PRP	denotes	itself
T5308	1678-1684	VB	denotes	impact
T5309	1685-1687	IN	denotes	on
T5310	1688-1691	DT	denotes	the
T5311	1692-1700	NN	denotes	strength
T5312	1701-1703	IN	denotes	of
T5313	1704-1714	NN	denotes	activation
T5314	1715-1717	IN	denotes	of
T5315	1718-1722	DT	denotes	this
T5316	1723-1731	JJ	denotes	specific
T5317	1732-1745	JJ	denotes	intracellular
T5318	1746-1756	NN	denotes	signalling
T5319	1757-1764	NN	denotes	pathway
T5320	1766-1768	TO	denotes	To
T5321	1769-1775	VB	denotes	search
T5322	1776-1779	IN	denotes	for
T5323	1780-1785	JJ	denotes	other
T5324	1786-1795	JJ	denotes	potential
T5325	1796-1799	NN	denotes	PKD
T5326	1800-1807	NN	denotes	targets
T5327	1808-1812	WDT	denotes	that
T5328	1813-1816	MD	denotes	may
T5329	1817-1821	VB	denotes	show
T5330	1822-1831	JJ	denotes	defective
T5331	1832-1842	NN	denotes	regulation
T5332	1843-1845	IN	denotes	in
T5333	1846-1855	NN	denotes	PKD1/3−/−
T5334	1856-1860	NN	denotes	DT40
T5335	1861-1862	NN	denotes	B
T5336	1863-1868	NN	denotes	cells
T5337	1868-1869	-COMMA-	denotes	,
T5338	1870-1872	PRP	denotes	we
T5339	1873-1877	VB	denotes	used
T5340	1878-1879	DT	denotes	a
T5341	1880-1883	NN	denotes	PKD
T5342	1884-1893	NN	denotes	substrate
T5343	1894-1910	NN	denotes	phospho-antibody
T5344	1911-1915	WDT	denotes	that
T5345	1916-1926	VB	denotes	recognises
T5346	1927-1936	NN	denotes	consensus
T5347	1937-1952	NN	denotes	phosphorylation
T5348	1953-1962	NN	denotes	sequences
T5349	1963-1971	VB	denotes	targeted
T5350	1972-1974	IN	denotes	by
T5351	1975-1978	NN	denotes	PKD
T5352	1979-1986	NN	denotes	enzymes
T5353	1987-1988	-LRB-	denotes	(
T5354	1988-1997	NN	denotes	LxRxxpS/T
T5355	1997-1998	-RRB-	denotes	)
T5356	1999-2000	-LRB-	denotes	[
T5357	2000-2002	CD	denotes	36
T5358	2002-2003	-RRB-	denotes	]
T5359	2005-2007	IN	denotes	As
T5360	2008-2013	VB	denotes	shown
T5361	2014-2016	IN	denotes	in
T5362	2017-2021	NNP	denotes	Fig.
T5363	2022-2024	NNP	denotes	3C
T5364	2024-2025	-COMMA-	denotes	,
T5365	2026-2033	NN	denotes	phorbol
T5366	2034-2040	NN	denotes	ester-
T5367	2041-2044	CC	denotes	and
T5368	2045-2056	JJ	denotes	BCR-induced
T5369	2057-2072	NN	denotes	phosphorylation
T5370	2073-2075	IN	denotes	of
T5371	2076-2084	JJ	denotes	cellular
T5372	2085-2095	NN	denotes	substrates
T5373	2096-2104	VB	denotes	detected
T5374	2105-2107	IN	denotes	by
T5375	2108-2112	DT	denotes	this
T5376	2113-2129	NN	denotes	phospho-antibody
T5377	2130-2133	VB	denotes	was
T5378	2134-2141	JJ	denotes	similar
T5379	2142-2144	IN	denotes	in
T5380	2145-2154	JJ	denotes	wild-type
T5381	2155-2158	CC	denotes	and
T5382	2159-2168	NN	denotes	PKD1/3−/−
T5383	2169-2174	NN	denotes	cells
T5384	2175-2178	CC	denotes	and
T5385	2179-2181	VB	denotes	is
T5386	2182-2191	RB	denotes	therefore
T5387	2192-2203	JJ	denotes	independent
T5388	2204-2206	IN	denotes	of
T5389	2207-2210	NN	denotes	PKD
T5390	2211-2218	NN	denotes	enzymes
T5391	2220-2227	RB	denotes	However
T5392	2227-2228	-COMMA-	denotes	,
T5393	2229-2241	NN	denotes	pretreatment
T5394	2242-2244	IN	denotes	of
T5395	2245-2249	CC	denotes	both
T5396	2250-2259	JJ	denotes	wild-type
T5397	2260-2263	CC	denotes	and
T5398	2264-2273	NN	denotes	PKD1/3−/−
T5399	2274-2278	NN	denotes	DT40
T5400	2279-2280	NN	denotes	B
T5401	2281-2286	NN	denotes	cells
T5402	2287-2291	IN	denotes	with
T5403	2292-2301	NN	denotes	GF109203X
T5404	2301-2302	-COMMA-	denotes	,
T5405	2303-2304	DT	denotes	a
T5406	2305-2323	NN	denotes	bisindoylmaleimide
T5407	2324-2334	NN	denotes	derivative
T5408	2335-2339	WDT	denotes	that
T5409	2340-2348	VB	denotes	inhibits
T5410	2349-2353	NN	denotes	PKCs
T5411	2354-2363	VB	denotes	prevented
T5412	2364-2367	DT	denotes	the
T5413	2368-2377	NN	denotes	induction
T5414	2378-2380	IN	denotes	of
T5415	2381-2389	NN	denotes	proteins
T5416	2390-2394	WDT	denotes	that
T5417	2395-2402	VB	denotes	contain
T5418	2403-2417	VB	denotes	phosphorylated
T5419	2418-2426	NN	denotes	LxRxxS/T
T5420	2427-2433	NN	denotes	motifs
T5421	2435-2439	RB	denotes	Thus
T5422	2440-2444	NN	denotes	loss
T5423	2445-2447	IN	denotes	of
T5424	2448-2454	NN	denotes	PKD1/3
T5425	2455-2462	NN	denotes	enzymes
T5426	2463-2467	VB	denotes	does
T5427	2468-2471	RB	denotes	not
T5428	2472-2480	RB	denotes	globally
T5429	2481-2488	VB	denotes	disrupt
T5430	2489-2492	DT	denotes	the
T5431	2493-2508	NN	denotes	phosphorylation
T5432	2509-2511	IN	denotes	of
T5433	2512-2520	JJ	denotes	cellular
T5434	2521-2529	NN	denotes	proteins
T5435	2530-2534	WDT	denotes	that
T5436	2535-2542	VB	denotes	contain
T5437	2543-2552	NN	denotes	LxRxxpS/T
T5438	2553-2559	NN	denotes	motifs
T5439	2561-2565	DT	denotes	This
T5440	2566-2572	NN	denotes	result
T5441	2573-2575	VB	denotes	is
T5442	2576-2583	RB	denotes	perhaps
T5443	2584-2587	RB	denotes	not
T5444	2588-2598	JJ	denotes	surprising
T5445	2599-2601	IN	denotes	as
T5446	2602-2610	NN	denotes	LxRxxS/T
T5447	2611-2617	NN	denotes	motifs
T5448	2618-2622	RB	denotes	also
T5449	2623-2626	VB	denotes	act
T5450	2627-2629	IN	denotes	as
T5451	2630-2634	JJ	denotes	good
T5452	2635-2645	NN	denotes	substrates
T5453	2646-2649	IN	denotes	for
T5454	2650-2655	JJ	denotes	other
T5455	2656-2672	NN	denotes	serine/threonine
T5456	2673-2680	NN	denotes	kinases
T5457	2681-2685	JJ	denotes	such
T5458	2686-2688	IN	denotes	as
T5459	2689-2697	NN	denotes	MAPKAPK2
T5460	2699-2706	RB	denotes	However
T5461	2707-2712	DT	denotes	these
T5462	2713-2724	NN	denotes	experiments
T5463	2725-2727	VB	denotes	do
T5464	2728-2735	VB	denotes	provide
T5465	2736-2743	JJ	denotes	further
T5466	2744-2752	NN	denotes	evidence
T5467	2753-2757	IN	denotes	that
T5468	2758-2773	JJ	denotes	phosphospecific
T5469	2774-2782	NN	denotes	antisera
T5470	2783-2786	VB	denotes	are
T5471	2787-2790	RB	denotes	not
T5472	2791-2803	RB	denotes	sufficiently
T5473	2804-2813	JJ	denotes	selective
T5474	2814-2816	TO	denotes	to
T5475	2817-2819	VB	denotes	be
T5476	2820-2830	VB	denotes	designated
T5477	2831-2837	NN	denotes	kinase
T5478	2838-2846	JJ	denotes	specific
T5479	2847-2856	NN	denotes	substrate
T5480	2857-2865	NN	denotes	antisera
T5481	2867-2878	JJ	denotes	BCR-induced
T5482	2879-2889	NN	denotes	signalling
T5483	2890-2898	NN	denotes	pathways
T5484	2899-2908	VB	denotes	culminate
T5485	2909-2911	IN	denotes	in
T5486	2912-2915	DT	denotes	the
T5487	2916-2926	NN	denotes	activation
T5488	2927-2929	IN	denotes	of
T5489	2930-2934	NN	denotes	gene
T5490	2935-2948	NN	denotes	transcription
T5491	2949-2955	NN	denotes	events
T5492	2956-2960	WDT	denotes	that
T5493	2961-2968	VB	denotes	control
T5494	2969-2970	NN	denotes	B
T5495	2971-2975	NN	denotes	cell
T5496	2976-2984	NN	denotes	survival
T5497	2984-2985	-COMMA-	denotes	,
T5498	2986-2999	NN	denotes	proliferation
T5499	3000-3003	CC	denotes	and
T5500	3004-3012	NN	denotes	function
T5501	3014-3016	IN	denotes	In
T5502	3017-3021	DT	denotes	this
T5503	3022-3029	NN	denotes	context
T5504	3029-3030	-COMMA-	denotes	,
T5505	3031-3033	PRP	denotes	it
T5506	3034-3037	VB	denotes	has
T5507	3038-3042	VB	denotes	been
T5508	3043-3051	VB	denotes	proposed
T5509	3052-3056	IN	denotes	that
T5510	3057-3060	NN	denotes	PKD
T5511	3061-3067	NN	denotes	family
T5512	3068-3075	NN	denotes	members
T5513	3076-3083	NN	denotes	control
T5514	3084-3086	IN	denotes	of
T5515	3087-3091	NN	denotes	gene
T5516	3092-3105	NN	denotes	transcription
T5517	3106-3113	IN	denotes	through
T5518	3114-3124	NN	denotes	activation
T5519	3125-3127	IN	denotes	of
T5520	3128-3131	DT	denotes	the
T5521	3132-3136	NN	denotes	NFκB
T5522	3137-3150	NN	denotes	transcription
T5523	3151-3157	NN	denotes	factor
T5524	3159-3163	RB	denotes	Thus
T5525	3163-3164	-COMMA-	denotes	,
T5526	3165-3177	JJ	denotes	PKD-mediated
T5527	3178-3188	NN	denotes	activation
T5528	3189-3191	IN	denotes	of
T5529	3192-3196	NN	denotes	NFκB
T5530	3197-3203	VB	denotes	occurs
T5531	3204-3214	RB	denotes	downstream
T5532	3215-3217	IN	denotes	of
T5533	3218-3219	DT	denotes	a
T5534	3220-3227	NN	denotes	variety
T5535	3228-3230	IN	denotes	of
T5536	3231-3240	JJ	denotes	different
T5537	3241-3248	NN	denotes	signals
T5538	3248-3249	-COMMA-	denotes	,
T5539	3250-3259	VB	denotes	including
T5540	3260-3274	JJ	denotes	mROS/oxidative
T5541	3275-3281	NN	denotes	stress
T5542	3281-3282	-COMMA-	denotes	,
T5543	3283-3299	JJ	denotes	lysophosphatidic
T5544	3300-3304	NN	denotes	acid
T5545	3305-3308	CC	denotes	and
T5546	3309-3312	DT	denotes	the
T5547	3313-3320	NN	denotes	Bcr-Abl
T5548	3321-3329	NN	denotes	oncogene
T5549	3330-3331	-LRB-	denotes	[
T5550	3331-3345	CD	denotes	17,21,23,30,37
T5551	3345-3346	-RRB-	denotes	]
T5552	3348-3359	RB	denotes	Furthermore
T5553	3359-3360	-COMMA-	denotes	,
T5554	3361-3371	NN	denotes	expression
T5555	3372-3374	IN	denotes	of
T5556	3375-3377	DT	denotes	an
T5557	3378-3387	VB	denotes	activated
T5558	3388-3392	NN	denotes	PKD1
T5559	3393-3399	NN	denotes	mutant
T5560	3400-3408	VB	denotes	enhances
T5561	3409-3422	JJ	denotes	HPK1-mediated
T5562	3423-3427	NN	denotes	NFκB
T5563	3428-3438	NN	denotes	activation
T5564	3439-3440	-LRB-	denotes	[
T5565	3440-3442	CD	denotes	38
T5566	3442-3443	-RRB-	denotes	]
T5567	3445-3447	IN	denotes	In
T5568	3448-3449	NN	denotes	B
T5569	3450-3455	NN	denotes	cells
T5570	3455-3456	-COMMA-	denotes	,
T5571	3457-3461	NN	denotes	NFκB
T5572	3462-3464	VB	denotes	is
T5573	3465-3470	VB	denotes	known
T5574	3471-3473	TO	denotes	to
T5575	3474-3476	VB	denotes	be
T5576	3477-3486	VB	denotes	regulated
T5577	3487-3490	IN	denotes	via
T5578	3491-3494	NN	denotes	DAG
T5579	3495-3498	CC	denotes	and
T5580	3499-3503	NN	denotes	PKCβ
T5581	3504-3505	-LRB-	denotes	[
T5582	3505-3510	CD	denotes	39,40
T5583	3510-3511	-RRB-	denotes	]
T5584	3512-3515	CC	denotes	but
T5585	3516-3523	IN	denotes	whether
T5586	3524-3528	NN	denotes	PKDs
T5587	3529-3532	VB	denotes	are
T5588	3533-3536	JJ	denotes	key
T5589	3537-3551	NN	denotes	intermediaries
T5590	3552-3555	IN	denotes	for
T5591	3556-3560	NN	denotes	NFκB
T5592	3561-3571	NN	denotes	regulation
T5593	3572-3575	VB	denotes	has
T5594	3576-3579	RB	denotes	not
T5595	3580-3584	VB	denotes	been
T5596	3585-3593	VB	denotes	explored
T5597	3595-3598	DT	denotes	The
T5598	3599-3603	NN	denotes	data
T5599	3604-3605	-LRB-	denotes	(
T5600	3605-3609	NNP	denotes	Fig.
T5601	3610-3612	NN	denotes	4A
T5602	3612-3613	-RRB-	denotes	)
T5603	3614-3618	VB	denotes	show
T5604	3619-3623	IN	denotes	that
T5605	3624-3628	NN	denotes	NFκB
T5606	3629-3644	JJ	denotes	transcriptional
T5607	3645-3653	NN	denotes	activity
T5608	3654-3657	VB	denotes	was
T5609	3658-3666	RB	denotes	strongly
T5610	3667-3674	VB	denotes	induced
T5611	3675-3677	IN	denotes	in
T5612	3678-3682	CC	denotes	both
T5613	3683-3692	JJ	denotes	wild-type
T5614	3693-3696	CC	denotes	and
T5615	3697-3706	NN	denotes	PKD1/3−/−
T5616	3707-3711	NN	denotes	DT40
T5617	3712-3713	NN	denotes	B
T5618	3714-3719	NN	denotes	cells
T5619	3720-3722	IN	denotes	in
T5620	3723-3731	NN	denotes	response
T5621	3732-3734	TO	denotes	to
T5622	3735-3741	CC	denotes	either
T5623	3742-3749	NN	denotes	phorbol
T5624	3750-3755	NN	denotes	ester
T5625	3756-3758	CC	denotes	or
T5626	3759-3762	NN	denotes	BCR
T5627	3763-3774	NN	denotes	stimulation
T5628	3776-3778	IN	denotes	In
T5629	3779-3787	NN	denotes	contrast
T5630	3787-3788	-COMMA-	denotes	,
T5631	3789-3792	NN	denotes	BCR
T5632	3793-3796	CC	denotes	and
T5633	3797-3804	NN	denotes	phorbol
T5634	3805-3818	JJ	denotes	ester-induced
T5635	3819-3823	NN	denotes	NFκB
T5636	3824-3839	JJ	denotes	transcriptional
T5637	3840-3848	NN	denotes	activity
T5638	3849-3852	VB	denotes	was
T5639	3853-3862	VB	denotes	abolished
T5640	3863-3865	IN	denotes	in
T5641	3866-3873	NN	denotes	PKCβ−/−
T5642	3874-3878	NN	denotes	DT40
T5643	3879-3880	NN	denotes	B
T5644	3881-3886	NN	denotes	cells
T5645	3887-3888	-LRB-	denotes	(
T5646	3888-3892	NN	denotes	Fig.
T5647	3893-3895	NN	denotes	4A
T5648	3895-3896	-RRB-	denotes	)
T5649	3896-3897	-COMMA-	denotes	,
T5650	3898-3906	IN	denotes	although
T5651	3907-3913	JJ	denotes	strong
T5652	3914-3924	NN	denotes	activation
T5653	3925-3927	IN	denotes	of
T5654	3928-3931	NN	denotes	PKD
T5655	3932-3939	NN	denotes	kinases
T5656	3940-3941	-LRB-	denotes	(
T5657	3941-3943	IN	denotes	as
T5658	3944-3952	VB	denotes	assessed
T5659	3953-3955	IN	denotes	by
T5660	3956-3975	NN	denotes	autophosphorylation
T5661	3976-3978	IN	denotes	of
T5662	3979-3983	NN	denotes	PKD1
T5663	3984-3986	IN	denotes	at
T5664	3987-3991	NN	denotes	S916
T5665	3991-3992	-RRB-	denotes	)
T5666	3993-3996	VB	denotes	was
T5667	3997-4005	VB	denotes	observed
T5668	4006-4008	IN	denotes	in
T5669	4009-4012	DT	denotes	the
T5670	4013-4020	NN	denotes	PKCβ−/−
T5671	4021-4026	NN	denotes	cells
T5672	4027-4028	-LRB-	denotes	(
T5673	4028-4032	NN	denotes	Fig.
T5674	4033-4035	NN	denotes	4B
T5675	4035-4036	-RRB-	denotes	)
T5676	4038-4042	RB	denotes	Thus
T5677	4042-4043	-COMMA-	denotes	,
T5678	4044-4047	NN	denotes	PKD
T5679	4048-4055	NN	denotes	kinases
T5680	4056-4059	VB	denotes	are
T5681	4060-4067	DT	denotes	neither
T5682	4068-4077	JJ	denotes	essential
T5683	4078-4081	CC	denotes	nor
T5684	4082-4092	JJ	denotes	sufficient
T5685	4093-4095	TO	denotes	to
T5686	4096-4103	VB	denotes	mediate
T5687	4104-4115	JJ	denotes	BCR-induced
T5688	4116-4120	NN	denotes	NFκB
T5689	4121-4131	NN	denotes	activation
T5690	4132-4134	IN	denotes	in
T5691	4135-4139	NN	denotes	DT40
T5692	4140-4141	NN	denotes	B
T5693	4142-4147	NN	denotes	cells
T5694	4148-4151	CC	denotes	and
T5695	4152-4157	RB	denotes	hence
T5696	4158-4160	VB	denotes	do
T5697	4161-4164	RB	denotes	not
T5698	4165-4176	VB	denotes	participate
T5699	4177-4179	IN	denotes	in
T5700	4180-4187	NN	denotes	DAG/PKC
T5701	4188-4196	VB	denotes	mediated
T5702	4197-4204	NN	denotes	control
T5703	4205-4207	IN	denotes	of
T5704	4208-4212	NN	denotes	NFκB
R3932	T5032	T5033	arg1Of	receptor,regulated
R3933	T5035	T5033	arg2Of	pathways,regulated
R3934	T5035	T5034	arg1Of	pathways,signalling
R3935	T5035	T5036	arg1Of	pathways,in
R3936	T5040	T5036	arg2Of	cells,in
R3937	T5040	T5037	arg1Of	cells,PKD-null
R3938	T5040	T5038	arg1Of	cells,DT40
R3939	T5040	T5039	arg1Of	cells,B
R3940	T5043	T5041	arg1Of	explore,To
R3941	T5043	T5042	arg1Of	explore,further
R3942	T5045	T5043	arg2Of	contribution,explore
R3943	T5045	T5044	arg1Of	contribution,the
R3944	T5045	T5046	arg1Of	contribution,of
R3945	T5045	T5049	arg1Of	contribution,to
R3946	T5048	T5046	arg2Of	kinases,of
R3947	T5048	T5047	arg1Of	kinases,PKD
R3948	T5053	T5049	arg2Of	biology,to
R3949	T5053	T5050	arg1Of	biology,DT40
R3950	T5053	T5051	arg1Of	biology,B
R3951	T5053	T5052	arg1Of	biology,cell
R3952	T5054	T5043	arg1Of	we,explore
R3953	T5054	T5055	arg1Of	we,investigated
R3954	T5055	T5041	modOf	investigated,To
R3955	T5058	T5057	arg1Of	BCR-regulated,specific
R3956	T5060	T5058	arg1Of	events,BCR-regulated
R3957	T5060	T5059	arg1Of	events,signalling
R3958	T5060	T5061	arg1Of	events,were
R3959	T5060	T5062	arg1Of	events,defective
R3960	T5061	T5055	arg2Of	were,investigated
R3961	T5061	T5056	arg1Of	were,whether
R3962	T5062	T5061	arg2Of	defective,were
R3963	T5062	T5063	arg1Of	defective,in
R3964	T5067	T5063	arg2Of	cells,in
R3965	T5067	T5064	arg1Of	cells,the
R3966	T5067	T5065	arg1Of	cells,PKD-null
R3967	T5067	T5066	arg1Of	cells,B
R3968	T5069	T5068	arg1Of	experiments,Initial
R3969	T5069	T5070	arg1Of	experiments,revealed
R3970	T5073	T5072	arg1Of	expression,surface
R3971	T5073	T5074	arg1Of	expression,of
R3972	T5073	T5077	arg1Of	expression,was
R3973	T5073	T5078	arg2Of	expression,reduced
R3974	T5076	T5074	arg2Of	BCR,of
R3975	T5076	T5075	arg1Of	BCR,the
R3976	T5078	T5070	arg2Of	reduced,revealed
R3977	T5078	T5071	arg1Of	reduced,that
R3978	T5078	T5077	arg2Of	reduced,was
R3979	T5078	T5079	arg1Of	reduced,in
R3980	T5078	T5089	arg1Of	reduced,compared
R3981	T5080	T5081	arg1Of	PKD1/3−/−,(
R3982	T5083	T5081	arg2Of	in,(
R3983	T5083	T5082	arg1Of	in,and
R3984	T5084	T5083	arg2Of	PKD1/3−/−,in
R3985	T5084	T5085	arg1Of	PKD1/3−/−,:
R3986	T5084	T5086	arg1Of	PKD1/3−/−,Flag-PKD3+ve
R3987	T5087	T5081	arg3Of	),(
R3988	T5088	T5079	arg2Of	cells,in
R3989	T5088	T5080	arg1Of	cells,PKD1/3−/−
R3990	T5090	T5089	arg2Of	to,compared
R3991	T5094	T5090	arg2Of	cells,to
R3992	T5094	T5091	arg1Of	cells,wild-type
R3993	T5094	T5092	arg1Of	cells,DT40
R3994	T5094	T5093	arg1Of	cells,B
R3995	T5094	T5095	arg1Of	cells,(
R3996	T5097	T5096	arg1Of	3A,Fig.
R3997	T5097	T5098	arg1Of	3A,and
R3998	T5098	T5095	arg2Of	and,(
R3999	T5099	T5098	arg2Of	data,and
R4000	T5099	T5101	arg2Of	data,shown
R4001	T5101	T5100	arg1Of	shown,not
R4002	T5102	T5095	arg3Of	),(
R4003	T5105	T5106	arg1Of	BCR-crosslinking,of
R4004	T5105	T5109	arg1Of	BCR-crosslinking,was
R4005	T5105	T5110	arg1Of	BCR-crosslinking,sufficient
R4006	T5105	T5112	arg1Of	BCR-crosslinking,induce
R4007	T5108	T5106	arg2Of	cells,of
R4008	T5108	T5107	arg1Of	cells,PKD1/3−/−
R4009	T5109	T5103	arg1Of	was,Nevertheless
R4010	T5109	T5104	arg1Of	was,","
R4011	T5110	T5109	arg2Of	sufficient,was
R4012	T5112	T5110	arg2Of	induce,sufficient
R4013	T5112	T5111	arg1Of	induce,to
R4014	T5114	T5112	arg2Of	activation,induce
R4015	T5114	T5113	arg1Of	activation,the
R4016	T5114	T5115	arg1Of	activation,of
R4017	T5117	T5115	arg2Of	number,of
R4018	T5117	T5116	arg1Of	number,a
R4019	T5117	T5118	arg1Of	number,of
R4020	T5117	T5121	arg1Of	number,","
R4021	T5117	T5122	arg1Of	number,similar
R4022	T5120	T5118	arg2Of	cascades,of
R4023	T5120	T5119	arg1Of	cascades,signalling
R4024	T5122	T5123	arg1Of	similar,to
R4025	T5124	T5123	arg2Of	that,to
R4026	T5124	T5125	arg2Of	that,observed
R4027	T5125	T5126	arg1Of	observed,in
R4028	T5128	T5126	arg2Of	cells,in
R4029	T5128	T5127	arg1Of	cells,wild-type
R4030	T5128	T5129	arg1Of	cells,(
R4031	T5131	T5129	arg2Of	3B,(
R4032	T5131	T5130	arg1Of	3B,Fig.
R4033	T5132	T5129	arg3Of	),(
R4034	T5136	T5135	arg1Of	activation,BCR-induced
R4035	T5136	T5137	arg1Of	activation,of
R4036	T5136	T5140	arg1Of	activation,","
R4037	T5139	T5137	arg2Of	Akt,of
R4038	T5139	T5138	arg1Of	Akt,the
R4039	T5140	T5153	arg1Of	",",and
R4040	T5143	T5140	arg2Of	kinase,","
R4041	T5143	T5141	arg1Of	kinase,mTOR/p70
R4042	T5143	T5142	arg1Of	kinase,S6
R4043	T5143	T5144	arg1Of	kinase,(
R4044	T5143	T5145	arg1Of	kinase,as
R4045	T5143	T5152	arg1Of	kinase,)
R4046	T5146	T5145	arg2Of	shown,as
R4047	T5151	T5146	arg1Of	phosphorylation,shown
R4048	T5151	T5147	arg2Of	phosphorylation,by
R4049	T5151	T5148	arg1Of	phosphorylation,S6
R4050	T5151	T5149	arg1Of	phosphorylation,ribosomal
R4051	T5151	T5150	arg1Of	phosphorylation,protein
R4052	T5153	T5157	arg1Of	and,was
R4053	T5153	T5159	arg1Of	and,detectable
R4054	T5156	T5153	arg2Of	pathways,and
R4055	T5156	T5154	arg1Of	pathways,MAPK
R4056	T5156	T5155	arg1Of	pathways,signalling
R4057	T5157	T5133	arg1Of	was,Hence
R4058	T5157	T5134	arg1Of	was,","
R4059	T5159	T5157	arg2Of	detectable,was
R4060	T5159	T5158	arg1Of	detectable,clearly
R4061	T5159	T5160	arg1Of	detectable,in
R4062	T5163	T5160	arg2Of	cells,in
R4063	T5163	T5161	arg1Of	cells,PKD1/3-null
R4064	T5163	T5162	arg1Of	cells,B
R4065	T5163	T5164	arg1Of	cells,(
R4066	T5166	T5164	arg2Of	3B,(
R4067	T5166	T5165	arg1Of	3B,Fig.
R4068	T5167	T5164	arg3Of	),(
R4069	T5172	T5170	arg2Of	phosphorylation,enhanced
R4070	T5172	T5171	arg1Of	phosphorylation,tyrosine
R4071	T5172	T5173	arg1Of	phosphorylation,of
R4072	T5172	T5179	arg1Of	phosphorylation,as
R4073	T5176	T5173	arg2Of	proteins,of
R4074	T5176	T5174	arg1Of	proteins,multiple
R4075	T5176	T5175	arg1Of	proteins,cellular
R4076	T5179	T5177	arg1Of	as,as
R4077	T5179	T5178	arg1Of	as,well
R4078	T5179	T5186	arg1Of	as,was
R4079	T5179	T5188	arg2Of	as,observed
R4080	T5181	T5179	arg2Of	increase,as
R4081	T5181	T5180	arg1Of	increase,an
R4082	T5181	T5182	arg1Of	increase,in
R4083	T5185	T5182	arg2Of	levels,in
R4084	T5185	T5183	arg1Of	levels,intracellular
R4085	T5185	T5184	arg1Of	levels,calcium
R4086	T5188	T5168	arg1Of	observed,Furthermore
R4087	T5188	T5169	arg1Of	observed,","
R4088	T5188	T5186	arg2Of	observed,was
R4089	T5188	T5187	arg1Of	observed,also
R4090	T5188	T5189	arg1Of	observed,following
R4091	T5191	T5189	arg2Of	stimulation,following
R4092	T5191	T5190	arg1Of	stimulation,BCR
R4093	T5191	T5192	arg1Of	stimulation,of
R4094	T5195	T5192	arg2Of	cells,of
R4095	T5195	T5193	arg1Of	cells,PKD1/3-null
R4096	T5195	T5194	arg1Of	cells,B
R4097	T5195	T5196	arg1Of	cells,(
R4098	T5197	T5196	arg2Of	data,(
R4099	T5197	T5199	arg2Of	data,shown
R4100	T5199	T5198	arg1Of	shown,not
R4101	T5200	T5196	arg3Of	),(
R4102	T5201	T5202	arg1Of	We,did
R4103	T5201	T5203	arg1Of	We,observe
R4104	T5203	T5202	arg2Of	observe,did
R4105	T5206	T5205	arg1Of	strength,the
R4106	T5206	T5207	arg1Of	strength,of
R4107	T5206	T5222	arg1Of	strength,was
R4108	T5206	T5223	arg2Of	strength,reduced
R4109	T5208	T5209	arg1Of	BCR,(
R4110	T5210	T5211	arg1Of	but,not
R4111	T5213	T5209	arg2Of	ester,(
R4112	T5213	T5210	arg1Of	ester,but
R4113	T5213	T5212	arg1Of	ester,phorbol
R4114	T5214	T5209	arg3Of	),(
R4115	T5216	T5207	arg2Of	regulation,of
R4116	T5216	T5208	arg1Of	regulation,BCR
R4117	T5216	T5215	arg1Of	regulation,-induced
R4118	T5216	T5217	arg1Of	regulation,of
R4119	T5221	T5217	arg2Of	pathway,of
R4120	T5221	T5218	arg1Of	pathway,the
R4121	T5221	T5219	arg1Of	pathway,Erk1-RSK1
R4122	T5221	T5220	arg1Of	pathway,signalling
R4123	T5223	T5203	arg2Of	reduced,observe
R4124	T5223	T5204	arg1Of	reduced,that
R4125	T5223	T5222	arg2Of	reduced,was
R4126	T5223	T5224	arg1Of	reduced,in
R4127	T5223	T5228	arg1Of	reduced,compared
R4128	T5227	T5224	arg2Of	cells,in
R4129	T5227	T5225	arg1Of	cells,PKD1/3−/−
R4130	T5227	T5226	arg1Of	cells,B
R4131	T5229	T5228	arg2Of	to,compared
R4132	T5232	T5229	arg2Of	cells,to
R4133	T5232	T5230	arg1Of	cells,wild-type
R4134	T5232	T5231	arg1Of	cells,B
R4135	T5232	T5233	arg1Of	cells,(
R4136	T5235	T5233	arg2Of	3B,(
R4137	T5235	T5234	arg1Of	3B,Fig.
R4138	T5236	T5233	arg3Of	),(
R4139	T5238	T5237	arg1Of	interpretation,One
R4140	T5238	T5239	arg1Of	interpretation,of
R4141	T5238	T5242	arg1Of	interpretation,is
R4142	T5241	T5239	arg2Of	data,of
R4143	T5241	T5240	arg1Of	data,this
R4144	T5245	T5244	arg1Of	enzymes,PKD
R4145	T5245	T5246	arg1Of	enzymes,may
R4146	T5245	T5247	arg1Of	enzymes,modulate
R4147	T5247	T5242	arg2Of	modulate,is
R4148	T5247	T5243	arg1Of	modulate,that
R4149	T5247	T5246	arg2Of	modulate,may
R4150	T5249	T5247	arg2Of	activation,modulate
R4151	T5249	T5248	arg1Of	activation,Erk
R4152	T5253	T5252	arg1Of	enzymes,PKD
R4153	T5253	T5254	arg1Of	enzymes,have
R4154	T5253	T5256	arg1Of	enzymes,been
R4155	T5253	T5257	arg2Of	enzymes,linked
R4156	T5257	T5250	arg1Of	linked,Indeed
R4157	T5257	T5251	arg1Of	linked,","
R4158	T5257	T5254	arg2Of	linked,have
R4159	T5257	T5255	arg1Of	linked,previously
R4160	T5257	T5256	arg2Of	linked,been
R4161	T5257	T5258	arg1Of	linked,to
R4162	T5257	T5264	arg1Of	linked,in
R4163	T5263	T5258	arg2Of	signalling,to
R4164	T5263	T5259	arg1Of	signalling,the
R4165	T5263	T5260	arg1Of	signalling,growth
R4166	T5263	T5261	arg1Of	signalling,factor-regulated
R4167	T5263	T5262	arg1Of	signalling,Erk
R4168	T5265	T5266	arg1Of	fibroblast,and
R4169	T5266	T5264	arg2Of	and,in
R4170	T5269	T5266	arg2Of	lines,and
R4171	T5269	T5267	arg1Of	lines,endothelial
R4172	T5269	T5268	arg1Of	lines,cell
R4173	T5269	T5270	arg1Of	lines,[
R4174	T5271	T5270	arg2Of	33–35,[
R4175	T5272	T5270	arg3Of	],[
R4176	T5277	T5275	arg1Of	phosphorylation,BCR-induced
R4177	T5277	T5276	arg1Of	phosphorylation,Erk
R4178	T5277	T5278	arg1Of	phosphorylation,was
R4179	T5277	T5280	arg2Of	phosphorylation,reduced
R4180	T5280	T5273	arg1Of	reduced,However
R4181	T5280	T5274	arg1Of	reduced,","
R4182	T5280	T5278	arg2Of	reduced,was
R4183	T5280	T5279	arg1Of	reduced,also
R4184	T5280	T5281	arg1Of	reduced,in
R4185	T5280	T5290	modOf	reduced,suggesting
R4186	T5284	T5281	arg2Of	cells,in
R4187	T5284	T5282	arg1Of	cells,PKD1/3−/−-Flag-PKD3+
R4188	T5284	T5283	arg1Of	cells,B
R4189	T5284	T5285	arg1Of	cells,(
R4190	T5286	T5285	arg2Of	data,(
R4191	T5286	T5288	arg2Of	data,shown
R4192	T5288	T5287	arg1Of	shown,not
R4193	T5289	T5285	arg3Of	),(
R4194	T5294	T5292	arg2Of	levels,reduced
R4195	T5294	T5293	arg1Of	levels,BCR
R4196	T5294	T5295	arg1Of	levels,on
R4197	T5294	T5306	arg1Of	levels,may
R4198	T5294	T5308	arg1Of	levels,impact
R4199	T5297	T5295	arg2Of	surface,on
R4200	T5297	T5296	arg1Of	surface,the
R4201	T5297	T5298	arg1Of	surface,of
R4202	T5299	T5300	arg1Of	PKD1/3−/−,(
R4203	T5302	T5300	arg2Of	PKD1/3−/−-Flag-PKD3+,(
R4204	T5302	T5301	arg1Of	PKD1/3−/−-Flag-PKD3+,and
R4205	T5303	T5300	arg3Of	),(
R4206	T5305	T5298	arg2Of	cells,of
R4207	T5305	T5299	arg1Of	cells,PKD1/3−/−
R4208	T5305	T5304	arg1Of	cells,B
R4209	T5308	T5290	arg2Of	impact,suggesting
R4210	T5308	T5291	arg1Of	impact,that
R4211	T5308	T5306	arg2Of	impact,may
R4212	T5308	T5307	arg1Of	impact,itself
R4213	T5308	T5309	arg1Of	impact,on
R4214	T5311	T5309	arg2Of	strength,on
R4215	T5311	T5310	arg1Of	strength,the
R4216	T5311	T5312	arg1Of	strength,of
R4217	T5313	T5312	arg2Of	activation,of
R4218	T5313	T5314	arg1Of	activation,of
R4219	T5319	T5314	arg2Of	pathway,of
R4220	T5319	T5315	arg1Of	pathway,this
R4221	T5319	T5316	arg1Of	pathway,specific
R4222	T5319	T5317	arg1Of	pathway,intracellular
R4223	T5319	T5318	arg1Of	pathway,signalling
R4224	T5321	T5320	arg1Of	search,To
R4225	T5321	T5322	arg1Of	search,for
R4226	T5326	T5322	arg2Of	targets,for
R4227	T5326	T5323	arg1Of	targets,other
R4228	T5326	T5324	arg1Of	targets,potential
R4229	T5326	T5325	arg1Of	targets,PKD
R4230	T5326	T5327	arg1Of	targets,that
R4231	T5326	T5328	arg1Of	targets,may
R4232	T5326	T5329	arg1Of	targets,show
R4233	T5329	T5328	arg2Of	show,may
R4234	T5329	T5332	arg1Of	show,in
R4235	T5331	T5329	arg2Of	regulation,show
R4236	T5331	T5330	arg1Of	regulation,defective
R4237	T5336	T5332	arg2Of	cells,in
R4238	T5336	T5333	arg1Of	cells,PKD1/3−/−
R4239	T5336	T5334	arg1Of	cells,DT40
R4240	T5336	T5335	arg1Of	cells,B
R4241	T5338	T5321	arg1Of	we,search
R4242	T5338	T5339	arg1Of	we,used
R4243	T5339	T5320	modOf	used,To
R4244	T5339	T5337	arg1Of	used,","
R4245	T5343	T5339	arg2Of	phospho-antibody,used
R4246	T5343	T5340	arg1Of	phospho-antibody,a
R4247	T5343	T5341	arg1Of	phospho-antibody,PKD
R4248	T5343	T5342	arg1Of	phospho-antibody,substrate
R4249	T5343	T5344	arg1Of	phospho-antibody,that
R4250	T5343	T5345	arg1Of	phospho-antibody,recognises
R4251	T5348	T5345	arg2Of	sequences,recognises
R4252	T5348	T5346	arg1Of	sequences,consensus
R4253	T5348	T5347	arg1Of	sequences,phosphorylation
R4254	T5348	T5349	arg2Of	sequences,targeted
R4255	T5349	T5356	arg1Of	targeted,[
R4256	T5352	T5349	arg1Of	enzymes,targeted
R4257	T5352	T5350	arg2Of	enzymes,by
R4258	T5352	T5351	arg1Of	enzymes,PKD
R4259	T5352	T5353	arg1Of	enzymes,(
R4260	T5354	T5353	arg2Of	LxRxxpS/T,(
R4261	T5355	T5353	arg3Of	),(
R4262	T5357	T5356	arg2Of	36,[
R4263	T5358	T5356	arg3Of	],[
R4264	T5360	T5359	arg2Of	shown,As
R4265	T5360	T5361	arg1Of	shown,in
R4266	T5363	T5361	arg2Of	3C,in
R4267	T5363	T5362	arg1Of	3C,Fig.
R4268	T5366	T5365	arg1Of	ester-,phorbol
R4269	T5366	T5367	arg1Of	ester-,and
R4270	T5368	T5367	arg2Of	BCR-induced,and
R4271	T5369	T5366	arg1Of	phosphorylation,ester-
R4272	T5369	T5368	arg1Of	phosphorylation,BCR-induced
R4273	T5369	T5370	arg1Of	phosphorylation,of
R4274	T5369	T5377	arg1Of	phosphorylation,was
R4275	T5369	T5378	arg1Of	phosphorylation,similar
R4276	T5369	T5385	arg1Of	phosphorylation,is
R4277	T5369	T5387	arg1Of	phosphorylation,independent
R4278	T5372	T5370	arg2Of	substrates,of
R4279	T5372	T5371	arg1Of	substrates,cellular
R4280	T5372	T5373	arg2Of	substrates,detected
R4281	T5376	T5373	arg1Of	phospho-antibody,detected
R4282	T5376	T5374	arg2Of	phospho-antibody,by
R4283	T5376	T5375	arg1Of	phospho-antibody,this
R4284	T5377	T5384	arg1Of	was,and
R4285	T5378	T5377	arg2Of	similar,was
R4286	T5378	T5379	arg1Of	similar,in
R4287	T5380	T5381	arg1Of	wild-type,and
R4288	T5381	T5379	arg2Of	and,in
R4289	T5383	T5381	arg2Of	cells,and
R4290	T5383	T5382	arg1Of	cells,PKD1/3−/−
R4291	T5384	T5359	arg1Of	and,As
R4292	T5384	T5364	arg1Of	and,","
R4293	T5385	T5384	arg2Of	is,and
R4294	T5385	T5386	arg1Of	is,therefore
R4295	T5387	T5385	arg2Of	independent,is
R4296	T5387	T5388	arg1Of	independent,of
R4297	T5390	T5388	arg2Of	enzymes,of
R4298	T5390	T5389	arg1Of	enzymes,PKD
R4299	T5393	T5394	arg1Of	pretreatment,of
R4300	T5393	T5402	arg1Of	pretreatment,with
R4301	T5393	T5411	arg1Of	pretreatment,prevented
R4302	T5401	T5394	arg2Of	cells,of
R4303	T5401	T5395	arg1Of	cells,both
R4304	T5401	T5396	arg1Of	cells,wild-type
R4305	T5401	T5397	arg1Of	cells,and
R4306	T5401	T5398	arg1Of	cells,PKD1/3−/−
R4307	T5401	T5399	arg1Of	cells,DT40
R4308	T5401	T5400	arg1Of	cells,B
R4309	T5403	T5402	arg2Of	GF109203X,with
R4310	T5403	T5404	arg1Of	GF109203X,","
R4311	T5407	T5404	arg2Of	derivative,","
R4312	T5407	T5405	arg1Of	derivative,a
R4313	T5407	T5406	arg1Of	derivative,bisindoylmaleimide
R4314	T5407	T5408	arg1Of	derivative,that
R4315	T5407	T5409	arg1Of	derivative,inhibits
R4316	T5410	T5409	arg2Of	PKCs,inhibits
R4317	T5411	T5391	arg1Of	prevented,However
R4318	T5411	T5392	arg1Of	prevented,","
R4319	T5413	T5411	arg2Of	induction,prevented
R4320	T5413	T5412	arg1Of	induction,the
R4321	T5413	T5414	arg1Of	induction,of
R4322	T5415	T5414	arg2Of	proteins,of
R4323	T5415	T5416	arg1Of	proteins,that
R4324	T5415	T5417	arg1Of	proteins,contain
R4325	T5420	T5417	arg2Of	motifs,contain
R4326	T5420	T5418	arg2Of	motifs,phosphorylated
R4327	T5420	T5419	arg1Of	motifs,LxRxxS/T
R4328	T5422	T5423	arg1Of	loss,of
R4329	T5422	T5426	arg1Of	loss,does
R4330	T5422	T5429	arg1Of	loss,disrupt
R4331	T5425	T5423	arg2Of	enzymes,of
R4332	T5425	T5424	arg1Of	enzymes,PKD1/3
R4333	T5429	T5421	arg1Of	disrupt,Thus
R4334	T5429	T5426	arg2Of	disrupt,does
R4335	T5429	T5427	arg1Of	disrupt,not
R4336	T5429	T5428	arg1Of	disrupt,globally
R4337	T5431	T5429	arg2Of	phosphorylation,disrupt
R4338	T5431	T5430	arg1Of	phosphorylation,the
R4339	T5431	T5432	arg1Of	phosphorylation,of
R4340	T5434	T5432	arg2Of	proteins,of
R4341	T5434	T5433	arg1Of	proteins,cellular
R4342	T5434	T5435	arg1Of	proteins,that
R4343	T5434	T5436	arg1Of	proteins,contain
R4344	T5438	T5436	arg2Of	motifs,contain
R4345	T5438	T5437	arg1Of	motifs,LxRxxpS/T
R4346	T5440	T5439	arg1Of	result,This
R4347	T5440	T5441	arg1Of	result,is
R4348	T5440	T5444	arg1Of	result,surprising
R4349	T5441	T5443	arg1Of	is,not
R4350	T5441	T5445	arg1Of	is,as
R4351	T5443	T5442	arg1Of	not,perhaps
R4352	T5444	T5441	arg2Of	surprising,is
R4353	T5447	T5446	arg1Of	motifs,LxRxxS/T
R4354	T5447	T5449	arg1Of	motifs,act
R4355	T5449	T5445	arg2Of	act,as
R4356	T5449	T5448	arg1Of	act,also
R4357	T5449	T5450	arg1Of	act,as
R4358	T5452	T5450	arg2Of	substrates,as
R4359	T5452	T5451	arg1Of	substrates,good
R4360	T5452	T5453	arg1Of	substrates,for
R4361	T5456	T5453	arg2Of	kinases,for
R4362	T5456	T5454	arg1Of	kinases,other
R4363	T5456	T5455	arg1Of	kinases,serine/threonine
R4364	T5456	T5458	arg1Of	kinases,as
R4365	T5458	T5457	arg1Of	as,such
R4366	T5459	T5458	arg2Of	MAPKAPK2,as
R4367	T5462	T5461	arg1Of	experiments,these
R4368	T5462	T5463	arg1Of	experiments,do
R4369	T5462	T5464	arg1Of	experiments,provide
R4370	T5464	T5460	arg1Of	provide,However
R4371	T5464	T5463	arg2Of	provide,do
R4372	T5466	T5464	arg2Of	evidence,provide
R4373	T5466	T5465	arg1Of	evidence,further
R4374	T5469	T5468	arg1Of	antisera,phosphospecific
R4375	T5469	T5470	arg1Of	antisera,are
R4376	T5469	T5473	arg1Of	antisera,selective
R4377	T5470	T5466	arg2Of	are,evidence
R4378	T5470	T5467	arg1Of	are,that
R4379	T5470	T5471	arg1Of	are,not
R4380	T5473	T5470	arg2Of	selective,are
R4381	T5473	T5472	arg1Of	selective,sufficiently
R4382	T5473	T5474	modOf	selective,to
R4383	T5476	T5474	arg1Of	designated,to
R4384	T5476	T5475	arg2Of	designated,be
R4385	T5478	T5477	arg1Of	specific,kinase
R4386	T5480	T5476	arg3Of	antisera,designated
R4387	T5480	T5478	arg1Of	antisera,specific
R4388	T5480	T5479	arg1Of	antisera,substrate
R4389	T5483	T5481	arg1Of	pathways,BCR-induced
R4390	T5483	T5482	arg1Of	pathways,signalling
R4391	T5483	T5484	arg1Of	pathways,culminate
R4392	T5484	T5485	arg1Of	culminate,in
R4393	T5487	T5485	arg2Of	activation,in
R4394	T5487	T5486	arg1Of	activation,the
R4395	T5487	T5488	arg1Of	activation,of
R4396	T5491	T5488	arg2Of	events,of
R4397	T5491	T5489	arg1Of	events,gene
R4398	T5491	T5490	arg1Of	events,transcription
R4399	T5491	T5492	arg1Of	events,that
R4400	T5491	T5493	arg1Of	events,control
R4401	T5496	T5497	arg1Of	survival,","
R4402	T5497	T5499	arg1Of	",",and
R4403	T5498	T5497	arg2Of	proliferation,","
R4404	T5499	T5493	arg2Of	and,control
R4405	T5499	T5494	arg1Of	and,B
R4406	T5499	T5495	arg1Of	and,cell
R4407	T5500	T5499	arg2Of	function,and
R4408	T5503	T5501	arg2Of	context,In
R4409	T5503	T5502	arg1Of	context,this
R4410	T5508	T5501	arg1Of	proposed,In
R4411	T5508	T5504	arg1Of	proposed,","
R4412	T5508	T5506	arg2Of	proposed,has
R4413	T5508	T5507	arg2Of	proposed,been
R4414	T5508	T5517	arg1Of	proposed,through
R4415	T5513	T5505	arg1Of	control,it
R4416	T5513	T5506	arg1Of	control,has
R4417	T5513	T5507	arg1Of	control,been
R4418	T5513	T5508	arg2Of	control,proposed
R4419	T5513	T5509	arg1Of	control,that
R4420	T5513	T5510	arg1Of	control,PKD
R4421	T5513	T5511	arg1Of	control,family
R4422	T5513	T5512	arg1Of	control,members
R4423	T5513	T5514	arg1Of	control,of
R4424	T5516	T5514	arg2Of	transcription,of
R4425	T5516	T5515	arg1Of	transcription,gene
R4426	T5518	T5517	arg2Of	activation,through
R4427	T5518	T5519	arg1Of	activation,of
R4428	T5523	T5519	arg2Of	factor,of
R4429	T5523	T5520	arg1Of	factor,the
R4430	T5523	T5521	arg1Of	factor,NFκB
R4431	T5523	T5522	arg1Of	factor,transcription
R4432	T5527	T5526	arg1Of	activation,PKD-mediated
R4433	T5527	T5528	arg1Of	activation,of
R4434	T5527	T5530	arg1Of	activation,occurs
R4435	T5529	T5528	arg2Of	NFκB,of
R4436	T5530	T5524	arg1Of	occurs,Thus
R4437	T5530	T5525	arg1Of	occurs,","
R4438	T5530	T5531	arg1Of	occurs,downstream
R4439	T5531	T5532	arg1Of	downstream,of
R4440	T5534	T5532	arg2Of	variety,of
R4441	T5534	T5533	arg1Of	variety,a
R4442	T5534	T5535	arg1Of	variety,of
R4443	T5537	T5535	arg2Of	signals,of
R4444	T5537	T5536	arg1Of	signals,different
R4445	T5537	T5538	arg1Of	signals,","
R4446	T5537	T5539	arg1Of	signals,including
R4447	T5541	T5540	arg1Of	stress,mROS/oxidative
R4448	T5541	T5542	arg1Of	stress,","
R4449	T5542	T5545	arg1Of	",",and
R4450	T5544	T5542	arg2Of	acid,","
R4451	T5544	T5543	arg1Of	acid,lysophosphatidic
R4452	T5545	T5539	arg2Of	and,including
R4453	T5547	T5546	arg1Of	Bcr-Abl,the
R4454	T5548	T5545	arg2Of	oncogene,and
R4455	T5548	T5547	arg1Of	oncogene,Bcr-Abl
R4456	T5548	T5549	arg1Of	oncogene,[
R4457	T5550	T5549	arg2Of	"17,21,23,30,37",[
R4458	T5551	T5549	arg3Of	],[
R4459	T5554	T5555	arg1Of	expression,of
R4460	T5554	T5560	arg1Of	expression,enhances
R4461	T5559	T5555	arg2Of	mutant,of
R4462	T5559	T5556	arg1Of	mutant,an
R4463	T5559	T5557	arg2Of	mutant,activated
R4464	T5559	T5558	arg1Of	mutant,PKD1
R4465	T5560	T5552	arg1Of	enhances,Furthermore
R4466	T5560	T5553	arg1Of	enhances,","
R4467	T5560	T5564	arg1Of	enhances,[
R4468	T5563	T5560	arg2Of	activation,enhances
R4469	T5563	T5561	arg1Of	activation,HPK1-mediated
R4470	T5563	T5562	arg1Of	activation,NFκB
R4471	T5565	T5564	arg2Of	38,[
R4472	T5566	T5564	arg3Of	],[
R4473	T5569	T5567	arg2Of	cells,In
R4474	T5569	T5568	arg1Of	cells,B
R4475	T5571	T5572	arg1Of	NFκB,is
R4476	T5571	T5573	arg2Of	NFκB,known
R4477	T5571	T5575	arg1Of	NFκB,be
R4478	T5571	T5576	arg2Of	NFκB,regulated
R4479	T5573	T5572	arg2Of	known,is
R4480	T5573	T5584	arg1Of	known,but
R4481	T5576	T5573	arg3Of	regulated,known
R4482	T5576	T5574	arg1Of	regulated,to
R4483	T5576	T5575	arg2Of	regulated,be
R4484	T5576	T5577	arg1Of	regulated,via
R4485	T5576	T5581	arg1Of	regulated,[
R4486	T5578	T5579	arg1Of	DAG,and
R4487	T5579	T5577	arg2Of	and,via
R4488	T5580	T5579	arg2Of	PKCβ,and
R4489	T5582	T5581	arg2Of	"39,40",[
R4490	T5583	T5581	arg3Of	],[
R4491	T5584	T5567	arg1Of	but,In
R4492	T5584	T5570	arg1Of	but,","
R4493	T5586	T5587	arg1Of	PKDs,are
R4494	T5587	T5585	arg1Of	are,whether
R4495	T5587	T5593	arg1Of	are,has
R4496	T5587	T5595	arg1Of	are,been
R4497	T5587	T5596	arg2Of	are,explored
R4498	T5589	T5587	arg2Of	intermediaries,are
R4499	T5589	T5588	arg1Of	intermediaries,key
R4500	T5589	T5590	arg1Of	intermediaries,for
R4501	T5592	T5590	arg2Of	regulation,for
R4502	T5592	T5591	arg1Of	regulation,NFκB
R4503	T5596	T5584	arg2Of	explored,but
R4504	T5596	T5593	arg2Of	explored,has
R4505	T5596	T5594	arg1Of	explored,not
R4506	T5596	T5595	arg2Of	explored,been
R4507	T5598	T5597	arg1Of	data,The
R4508	T5598	T5599	arg1Of	data,(
R4509	T5598	T5603	arg1Of	data,show
R4510	T5601	T5599	arg2Of	4A,(
R4511	T5601	T5600	arg1Of	4A,Fig.
R4512	T5602	T5599	arg3Of	),(
R4513	T5607	T5605	arg1Of	activity,NFκB
R4514	T5607	T5606	arg1Of	activity,transcriptional
R4515	T5607	T5608	arg1Of	activity,was
R4516	T5607	T5610	arg2Of	activity,induced
R4517	T5610	T5603	arg2Of	induced,show
R4518	T5610	T5604	arg1Of	induced,that
R4519	T5610	T5608	arg2Of	induced,was
R4520	T5610	T5609	arg1Of	induced,strongly
R4521	T5610	T5611	arg1Of	induced,in
R4522	T5610	T5619	arg1Of	induced,in
R4523	T5618	T5611	arg2Of	cells,in
R4524	T5618	T5612	arg1Of	cells,both
R4525	T5618	T5613	arg1Of	cells,wild-type
R4526	T5618	T5614	arg1Of	cells,and
R4527	T5618	T5615	arg1Of	cells,PKD1/3−/−
R4528	T5618	T5616	arg1Of	cells,DT40
R4529	T5618	T5617	arg1Of	cells,B
R4530	T5620	T5619	arg2Of	response,in
R4531	T5620	T5621	arg1Of	response,to
R4532	T5624	T5623	arg1Of	ester,phorbol
R4533	T5624	T5625	arg1Of	ester,or
R4534	T5625	T5621	arg2Of	or,to
R4535	T5625	T5622	arg1Of	or,either
R4536	T5627	T5625	arg2Of	stimulation,or
R4537	T5627	T5626	arg1Of	stimulation,BCR
R4538	T5629	T5628	arg2Of	contrast,In
R4539	T5631	T5666	arg1Of	BCR,was
R4540	T5631	T5667	arg2Of	BCR,observed
R4541	T5634	T5632	arg1Of	ester-induced,and
R4542	T5634	T5633	arg1Of	ester-induced,phorbol
R4543	T5637	T5634	arg1Of	activity,ester-induced
R4544	T5637	T5635	arg1Of	activity,NFκB
R4545	T5637	T5636	arg1Of	activity,transcriptional
R4546	T5637	T5638	arg1Of	activity,was
R4547	T5637	T5639	arg2Of	activity,abolished
R4548	T5639	T5638	arg2Of	abolished,was
R4549	T5639	T5640	arg1Of	abolished,in
R4550	T5639	T5649	arg1Of	abolished,","
R4551	T5639	T5650	arg1Of	abolished,although
R4552	T5639	T5656	arg1Of	abolished,(
R4553	T5644	T5640	arg2Of	cells,in
R4554	T5644	T5641	arg1Of	cells,PKCβ−/−
R4555	T5644	T5642	arg1Of	cells,DT40
R4556	T5644	T5643	arg1Of	cells,B
R4557	T5644	T5645	arg1Of	cells,(
R4558	T5647	T5645	arg2Of	4A,(
R4559	T5647	T5646	arg1Of	4A,Fig.
R4560	T5648	T5645	arg3Of	),(
R4561	T5652	T5650	arg2Of	activation,although
R4562	T5652	T5651	arg1Of	activation,strong
R4563	T5652	T5653	arg1Of	activation,of
R4564	T5655	T5653	arg2Of	kinases,of
R4565	T5655	T5654	arg1Of	kinases,PKD
R4566	T5657	T5656	arg2Of	as,(
R4567	T5658	T5657	arg2Of	assessed,as
R4568	T5658	T5659	arg1Of	assessed,by
R4569	T5660	T5659	arg2Of	autophosphorylation,by
R4570	T5660	T5661	arg1Of	autophosphorylation,of
R4571	T5660	T5663	arg1Of	autophosphorylation,at
R4572	T5662	T5661	arg2Of	PKD1,of
R4573	T5664	T5663	arg2Of	S916,at
R4574	T5665	T5656	arg3Of	),(
R4575	T5667	T5628	arg1Of	observed,In
R4576	T5667	T5630	arg1Of	observed,","
R4577	T5667	T5638	modOf	observed,was
R4578	T5667	T5666	arg2Of	observed,was
R4579	T5667	T5668	arg1Of	observed,in
R4580	T5671	T5668	arg2Of	cells,in
R4581	T5671	T5669	arg1Of	cells,the
R4582	T5671	T5670	arg1Of	cells,PKCβ−/−
R4583	T5671	T5672	arg1Of	cells,(
R4584	T5674	T5672	arg2Of	4B,(
R4585	T5674	T5673	arg1Of	4B,Fig.
R4586	T5675	T5672	arg3Of	),(
R4587	T5679	T5678	arg1Of	kinases,PKD
R4588	T5679	T5680	arg1Of	kinases,are
R4589	T5679	T5682	arg1Of	kinases,essential
R4590	T5679	T5684	arg1Of	kinases,sufficient
R4591	T5679	T5686	arg1Of	kinases,mediate
R4592	T5679	T5696	arg1Of	kinases,do
R4593	T5679	T5698	arg1Of	kinases,participate
R4594	T5680	T5694	arg1Of	are,and
R4595	T5682	T5683	arg1Of	essential,nor
R4596	T5683	T5680	arg2Of	nor,are
R4597	T5683	T5681	arg1Of	nor,neither
R4598	T5684	T5683	arg2Of	sufficient,nor
R4599	T5686	T5682	arg2Of	mediate,essential
R4600	T5686	T5684	arg2Of	mediate,sufficient
R4601	T5686	T5685	arg1Of	mediate,to
R4602	T5689	T5686	arg2Of	activation,mediate
R4603	T5689	T5687	arg1Of	activation,BCR-induced
R4604	T5689	T5688	arg1Of	activation,NFκB
R4605	T5689	T5690	arg1Of	activation,in
R4606	T5693	T5690	arg2Of	cells,in
R4607	T5693	T5691	arg1Of	cells,DT40
R4608	T5693	T5692	arg1Of	cells,B
R4609	T5694	T5676	arg1Of	and,Thus
R4610	T5694	T5677	arg1Of	and,","
R4611	T5698	T5694	arg2Of	participate,and
R4612	T5698	T5695	arg1Of	participate,hence
R4613	T5698	T5696	arg2Of	participate,do
R4614	T5698	T5697	arg1Of	participate,not
R4615	T5698	T5699	arg1Of	participate,in
R4616	T5702	T5699	arg2Of	control,in
R4617	T5702	T5700	arg1Of	control,DAG/PKC
R4618	T5702	T5701	arg2Of	control,mediated
R4619	T5702	T5703	arg1Of	control,of
R4620	T5704	T5703	arg2Of	NFκB,of

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T5769	5-12	NN	denotes	Antigen
T5770	13-21	NN	denotes	receptor
T5771	22-31	VBN	denotes	regulated
T5772	32-42	JJ	denotes	signalling
T5773	43-51	NNS	denotes	pathways
T5774	52-54	IN	denotes	in
T5775	55-63	NNP	denotes	PKD-null
T5776	64-68	NNP	denotes	DT40
T5777	69-70	NNP	denotes	B
T5778	71-76	NNS	denotes	cells
T5779	77-79	TO	denotes	To
T5780	80-87	RBR	denotes	further
T5781	88-95	VB	denotes	explore
T5782	96-99	DT	denotes	the
T5783	100-112	NN	denotes	contribution
T5784	113-115	IN	denotes	of
T5785	116-119	NNP	denotes	PKD
T5786	120-127	VBZ	denotes	kinases
T5787	128-130	TO	denotes	to
T5788	131-135	NNP	denotes	DT40
T5789	136-137	NNP	denotes	B
T5790	138-142	NN	denotes	cell
T5791	143-150	NN	denotes	biology
T5792	151-153	PRP	denotes	we
T5793	154-166	VBD	denotes	investigated
T5794	167-174	IN	denotes	whether
T5795	175-183	JJ	denotes	specific
T5796	184-197	JJ	denotes	BCR-regulated
T5797	198-208	JJ	denotes	signalling
T5798	209-215	NNS	denotes	events
T5799	216-220	VBD	denotes	were
T5800	221-230	JJ	denotes	defective
T5801	231-233	IN	denotes	in
T5802	234-237	DT	denotes	the
T5803	238-246	NNP	denotes	PKD-null
T5804	247-248	NNP	denotes	B
T5805	249-254	NNS	denotes	cells
T5806	254-255	.	denotes	.
T5807	256-263	JJ	denotes	Initial
T5808	264-275	NNS	denotes	experiments
T5809	276-284	VBD	denotes	revealed
T5810	285-289	IN	denotes	that
T5811	290-297	NN	denotes	surface
T5812	298-308	NN	denotes	expression
T5813	309-311	IN	denotes	of
T5814	312-315	DT	denotes	the
T5815	316-319	NNP	denotes	BCR
T5816	320-323	VBD	denotes	was
T5817	324-331	VBN	denotes	reduced
T5818	332-334	IN	denotes	in
T5819	335-341	CD	denotes	PKD1/3
T5820	341-342	CD	denotes	−
T5821	342-343	NN	denotes	/
T5822	343-344	NN	denotes	−
T5823	345-346	-LRB-	denotes	(
T5824	346-349	CC	denotes	and
T5825	350-352	IN	denotes	in
T5826	353-359	CD	denotes	PKD1/3
T5827	359-360	CD	denotes	−
T5828	360-361	NN	denotes	/
T5829	361-362	NN	denotes	−
T5830	362-363	:	denotes	:
T5831	363-372	NN	denotes	Flag-PKD3
T5832	372-373	NN	denotes	+
T5833	373-375	NN	denotes	ve
T5834	375-376	-RRB-	denotes	)
T5835	377-382	NNS	denotes	cells
T5836	383-391	VBN	denotes	compared
T5837	392-394	TO	denotes	to
T5838	395-404	JJ	denotes	wild-type
T5839	405-409	NNP	denotes	DT40
T5840	410-411	NNP	denotes	B
T5841	412-417	NNS	denotes	cells
T5842	418-419	-LRB-	denotes	(
T5843	419-423	NNP	denotes	Fig.
T5844	424-426	NNP	denotes	3A
T5845	427-430	CC	denotes	and
T5846	431-435	NNS	denotes	data
T5847	436-439	RB	denotes	not
T5848	440-445	VBN	denotes	shown
T5849	445-446	-RRB-	denotes	)
T5850	446-447	.	denotes	.
T5851	448-460	RB	denotes	Nevertheless
T5852	460-461	,	denotes	,
T5853	462-478	JJ	denotes	BCR-crosslinking
T5854	479-481	IN	denotes	of
T5855	482-488	CD	denotes	PKD1/3
T5856	488-489	CD	denotes	−
T5857	489-490	NN	denotes	/
T5858	490-491	NN	denotes	−
T5859	492-497	NNS	denotes	cells
T5860	498-501	VBD	denotes	was
T5861	502-512	JJ	denotes	sufficient
T5862	513-515	TO	denotes	to
T5863	516-522	VB	denotes	induce
T5864	523-526	DT	denotes	the
T5865	527-537	NN	denotes	activation
T5866	538-540	IN	denotes	of
T5867	541-542	DT	denotes	a
T5868	543-549	NN	denotes	number
T5869	550-552	IN	denotes	of
T5870	553-563	VBG	denotes	signalling
T5871	564-572	NNS	denotes	cascades
T5872	572-573	,	denotes	,
T5873	574-581	JJ	denotes	similar
T5874	582-584	TO	denotes	to
T5875	585-589	DT	denotes	that
T5876	590-598	VBN	denotes	observed
T5877	599-601	IN	denotes	in
T5878	602-611	JJ	denotes	wild-type
T5879	612-617	NNS	denotes	cells
T5880	618-619	-LRB-	denotes	(
T5881	619-623	NNP	denotes	Fig.
T5882	624-626	NNP	denotes	3B
T5883	626-627	-RRB-	denotes	)
T5884	627-628	.	denotes	.
T5885	629-634	RB	denotes	Hence
T5886	634-635	,	denotes	,
T5887	636-647	JJ	denotes	BCR-induced
T5888	648-658	NN	denotes	activation
T5889	659-661	IN	denotes	of
T5890	662-665	DT	denotes	the
T5891	666-669	NNP	denotes	Akt
T5892	669-670	,	denotes	,
T5893	671-679	NNP	denotes	mTOR/p70
T5894	680-682	NNP	denotes	S6
T5895	683-689	NN	denotes	kinase
T5896	690-691	-LRB-	denotes	(
T5897	691-693	IN	denotes	as
T5898	694-699	VBN	denotes	shown
T5899	700-702	IN	denotes	by
T5900	703-705	CD	denotes	S6
T5901	706-715	JJ	denotes	ribosomal
T5902	716-723	NN	denotes	protein
T5903	724-739	NN	denotes	phosphorylation
T5904	739-740	-RRB-	denotes	)
T5905	741-744	CC	denotes	and
T5906	745-749	NNP	denotes	MAPK
T5907	750-760	VBG	denotes	signalling
T5908	761-769	NNS	denotes	pathways
T5909	770-773	VBD	denotes	was
T5910	774-781	RB	denotes	clearly
T5911	782-792	JJ	denotes	detectable
T5912	793-795	IN	denotes	in
T5913	796-807	NNP	denotes	PKD1/3-null
T5914	808-809	NNP	denotes	B
T5915	810-815	NNS	denotes	cells
T5916	816-817	-LRB-	denotes	(
T5917	817-821	NNP	denotes	Fig.
T5918	822-824	NNP	denotes	3B
T5919	824-825	-RRB-	denotes	)
T5920	825-826	.	denotes	.
T5921	827-838	RB	denotes	Furthermore
T5922	838-839	,	denotes	,
T5923	840-848	JJ	denotes	enhanced
T5924	849-857	NN	denotes	tyrosine
T5925	858-873	NN	denotes	phosphorylation
T5926	874-876	IN	denotes	of
T5927	877-885	JJ	denotes	multiple
T5928	886-894	JJ	denotes	cellular
T5929	895-903	NNS	denotes	proteins
T5930	904-906	RB	denotes	as
T5931	907-911	RB	denotes	well
T5932	912-914	IN	denotes	as
T5933	915-917	DT	denotes	an
T5934	918-926	NN	denotes	increase
T5935	927-929	IN	denotes	in
T5936	930-943	JJ	denotes	intracellular
T5937	944-951	NN	denotes	calcium
T5938	952-958	NNS	denotes	levels
T5939	959-962	VBD	denotes	was
T5940	963-967	RB	denotes	also
T5941	968-976	VBN	denotes	observed
T5942	977-986	VBG	denotes	following
T5943	987-990	NNP	denotes	BCR
T5944	991-1002	NN	denotes	stimulation
T5945	1003-1005	IN	denotes	of
T5946	1006-1017	NNP	denotes	PKD1/3-null
T5947	1018-1019	NNP	denotes	B
T5948	1020-1025	NNS	denotes	cells
T5949	1026-1027	-LRB-	denotes	(
T5950	1027-1031	NNS	denotes	data
T5951	1032-1035	RB	denotes	not
T5952	1036-1041	VBN	denotes	shown
T5953	1041-1042	-RRB-	denotes	)
T5954	1042-1043	.	denotes	.
T5955	1044-1046	PRP	denotes	We
T5956	1047-1050	VBD	denotes	did
T5957	1051-1058	VB	denotes	observe
T5958	1059-1063	IN	denotes	that
T5959	1064-1067	DT	denotes	the
T5960	1068-1076	NN	denotes	strength
T5961	1077-1079	IN	denotes	of
T5962	1080-1083	NNP	denotes	BCR
T5963	1084-1085	-LRB-	denotes	(
T5964	1085-1088	CC	denotes	but
T5965	1089-1092	RB	denotes	not
T5966	1093-1100	VB	denotes	phorbol
T5967	1101-1106	NN	denotes	ester
T5968	1106-1107	-RRB-	denotes	)
T5969	1107-1108	:	denotes	-
T5970	1108-1115	VBD	denotes	induced
T5971	1116-1126	NN	denotes	regulation
T5972	1127-1129	IN	denotes	of
T5973	1130-1133	DT	denotes	the
T5974	1134-1143	JJ	denotes	Erk1-RSK1
T5975	1144-1154	NN	denotes	signalling
T5976	1155-1162	NN	denotes	pathway
T5977	1163-1166	VBD	denotes	was
T5978	1167-1174	VBN	denotes	reduced
T5979	1175-1177	IN	denotes	in
T5980	1178-1184	CD	denotes	PKD1/3
T5981	1184-1185	CD	denotes	−
T5982	1185-1186	NN	denotes	/
T5983	1186-1187	NN	denotes	−
T5984	1188-1189	NNP	denotes	B
T5985	1190-1195	NNS	denotes	cells
T5986	1196-1204	VBN	denotes	compared
T5987	1205-1207	TO	denotes	to
T5988	1208-1217	JJ	denotes	wild-type
T5989	1218-1219	NNP	denotes	B
T5990	1220-1225	NNS	denotes	cells
T5991	1226-1227	-LRB-	denotes	(
T5992	1227-1231	NNP	denotes	Fig.
T5993	1232-1234	NNP	denotes	3B
T5994	1234-1235	-RRB-	denotes	)
T5995	1235-1236	.	denotes	.
T5996	1237-1240	CD	denotes	One
T5997	1241-1255	NN	denotes	interpretation
T5998	1256-1258	IN	denotes	of
T5999	1259-1263	DT	denotes	this
T6000	1264-1268	NN	denotes	data
T6001	1269-1271	VBZ	denotes	is
T6002	1272-1276	IN	denotes	that
T6003	1277-1280	NNP	denotes	PKD
T6004	1281-1288	VBZ	denotes	enzymes
T6005	1289-1292	MD	denotes	may
T6006	1293-1301	VB	denotes	modulate
T6007	1302-1305	NNP	denotes	Erk
T6008	1306-1316	NN	denotes	activation
T6009	1316-1317	.	denotes	.
T6010	1318-1324	RB	denotes	Indeed
T6011	1324-1325	,	denotes	,
T6012	1326-1329	NNP	denotes	PKD
T6013	1330-1337	NNS	denotes	enzymes
T6014	1338-1342	VBP	denotes	have
T6015	1343-1353	RB	denotes	previously
T6016	1354-1358	VBN	denotes	been
T6017	1359-1365	VBN	denotes	linked
T6018	1366-1368	TO	denotes	to
T6019	1369-1372	DT	denotes	the
T6020	1373-1379	NN	denotes	growth
T6021	1380-1396	JJ	denotes	factor-regulated
T6022	1397-1400	NNP	denotes	Erk
T6023	1401-1411	NN	denotes	signalling
T6024	1412-1414	IN	denotes	in
T6025	1415-1425	NN	denotes	fibroblast
T6026	1426-1429	CC	denotes	and
T6027	1430-1441	JJ	denotes	endothelial
T6028	1442-1446	NN	denotes	cell
T6029	1447-1452	NNS	denotes	lines
T6030	1453-1454	NNP	denotes	[
T6031	1454-1456	CD	denotes	33
T6032	1457-1459	CD	denotes	35
T6033	1459-1460	NN	denotes	]
T6034	1460-1461	.	denotes	.
T6035	1462-1469	RB	denotes	However
T6036	1469-1470	,	denotes	,
T6037	1471-1482	JJ	denotes	BCR-induced
T6038	1483-1486	NNP	denotes	Erk
T6039	1487-1502	NN	denotes	phosphorylation
T6040	1503-1506	VBD	denotes	was
T6041	1507-1511	RB	denotes	also
T6042	1512-1519	VBN	denotes	reduced
T6043	1520-1522	IN	denotes	in
T6044	1523-1529	CD	denotes	PKD1/3
T6045	1529-1530	CD	denotes	−
T6046	1530-1531	NN	denotes	/
T6047	1531-1532	SYM	denotes	−
T6048	1532-1533	:	denotes	-
T6049	1533-1542	NN	denotes	Flag-PKD3
T6050	1542-1543	NN	denotes	+
T6051	1544-1545	NNP	denotes	B
T6052	1546-1551	NNS	denotes	cells
T6053	1552-1553	-LRB-	denotes	(
T6054	1553-1557	NNS	denotes	data
T6055	1558-1561	RB	denotes	not
T6056	1562-1567	VBN	denotes	shown
T6057	1567-1568	-RRB-	denotes	)
T6058	1569-1579	VBG	denotes	suggesting
T6059	1580-1584	IN	denotes	that
T6060	1585-1592	VBN	denotes	reduced
T6061	1593-1596	NNP	denotes	BCR
T6062	1597-1603	NNS	denotes	levels
T6063	1604-1606	IN	denotes	on
T6064	1607-1610	DT	denotes	the
T6065	1611-1618	NN	denotes	surface
T6066	1619-1621	IN	denotes	of
T6067	1622-1628	CD	denotes	PKD1/3
T6068	1628-1629	CD	denotes	−
T6069	1629-1630	NN	denotes	/
T6070	1630-1631	NN	denotes	−
T6071	1632-1633	-LRB-	denotes	(
T6072	1633-1636	CC	denotes	and
T6073	1637-1643	NNP	denotes	PKD1/3
T6074	1643-1644	VBD	denotes	−
T6075	1644-1645	CD	denotes	/
T6076	1645-1646	SYM	denotes	−
T6077	1646-1647	:	denotes	-
T6078	1647-1656	NN	denotes	Flag-PKD3
T6079	1656-1657	NN	denotes	+
T6080	1657-1658	-RRB-	denotes	)
T6081	1659-1660	NNP	denotes	B
T6082	1661-1666	NNS	denotes	cells
T6083	1667-1670	MD	denotes	may
T6084	1671-1677	PRP	denotes	itself
T6085	1678-1684	VB	denotes	impact
T6086	1685-1687	IN	denotes	on
T6087	1688-1691	DT	denotes	the
T6088	1692-1700	NN	denotes	strength
T6089	1701-1703	IN	denotes	of
T6090	1704-1714	NN	denotes	activation
T6091	1715-1717	IN	denotes	of
T6092	1718-1722	DT	denotes	this
T6093	1723-1731	JJ	denotes	specific
T6094	1732-1745	JJ	denotes	intracellular
T6095	1746-1756	NN	denotes	signalling
T6096	1757-1764	NN	denotes	pathway
T6097	1764-1765	.	denotes	.
T6098	1766-1768	TO	denotes	To
T6099	1769-1775	VB	denotes	search
T6100	1776-1779	IN	denotes	for
T6101	1780-1785	JJ	denotes	other
T6102	1786-1795	JJ	denotes	potential
T6103	1796-1799	NNP	denotes	PKD
T6104	1800-1807	NNS	denotes	targets
T6105	1808-1812	WDT	denotes	that
T6106	1813-1816	MD	denotes	may
T6107	1817-1821	VB	denotes	show
T6108	1822-1831	JJ	denotes	defective
T6109	1832-1842	NN	denotes	regulation
T6110	1843-1845	IN	denotes	in
T6111	1846-1852	NNP	denotes	PKD1/3
T6112	1852-1853	NNP	denotes	−
T6113	1853-1854	NNP	denotes	/
T6114	1854-1855	NNP	denotes	−
T6115	1856-1860	NNP	denotes	DT40
T6116	1861-1862	NNP	denotes	B
T6117	1863-1868	NNS	denotes	cells
T6118	1868-1869	,	denotes	,
T6119	1870-1872	PRP	denotes	we
T6120	1873-1877	VBD	denotes	used
T6121	1878-1879	DT	denotes	a
T6122	1880-1883	NNP	denotes	PKD
T6123	1884-1893	VB	denotes	substrate
T6124	1894-1910	JJ	denotes	phospho-antibody
T6125	1911-1915	IN	denotes	that
T6126	1916-1926	VBZ	denotes	recognises
T6127	1927-1936	NN	denotes	consensus
T6128	1937-1952	NN	denotes	phosphorylation
T6129	1953-1962	NNS	denotes	sequences
T6130	1963-1971	VBN	denotes	targeted
T6131	1972-1974	IN	denotes	by
T6132	1975-1978	NNP	denotes	PKD
T6133	1979-1986	VBZ	denotes	enzymes
T6134	1987-1988	-LRB-	denotes	(
T6135	1988-1997	NNP	denotes	LxRxxpS/T
T6136	1997-1998	-RRB-	denotes	)
T6137	1999-2000	NNP	denotes	[
T6138	2000-2002	CD	denotes	36
T6139	2002-2003	NNP	denotes	]
T6140	2003-2004	.	denotes	.
T6141	2005-2007	IN	denotes	As
T6142	2008-2013	VBN	denotes	shown
T6143	2014-2016	IN	denotes	in
T6144	2017-2021	NNP	denotes	Fig.
T6145	2022-2024	NNP	denotes	3C
T6146	2024-2025	,	denotes	,
T6147	2026-2033	NN	denotes	phorbol
T6148	2034-2039	NN	denotes	ester
T6149	2039-2040	:	denotes	-
T6150	2041-2044	CC	denotes	and
T6151	2045-2056	JJ	denotes	BCR-induced
T6152	2057-2072	NN	denotes	phosphorylation
T6153	2073-2075	IN	denotes	of
T6154	2076-2084	JJ	denotes	cellular
T6155	2085-2095	NNS	denotes	substrates
T6156	2096-2104	VBN	denotes	detected
T6157	2105-2107	IN	denotes	by
T6158	2108-2112	DT	denotes	this
T6159	2113-2129	NN	denotes	phospho-antibody
T6160	2130-2133	VBD	denotes	was
T6161	2134-2141	JJ	denotes	similar
T6162	2142-2144	IN	denotes	in
T6163	2145-2154	JJ	denotes	wild-type
T6164	2155-2158	CC	denotes	and
T6165	2159-2165	JJ	denotes	PKD1/3
T6166	2165-2166	NN	denotes	−
T6167	2166-2167	NN	denotes	/
T6168	2167-2168	NN	denotes	−
T6169	2169-2174	NNS	denotes	cells
T6170	2175-2178	CC	denotes	and
T6171	2179-2181	VBZ	denotes	is
T6172	2182-2191	RB	denotes	therefore
T6173	2192-2203	JJ	denotes	independent
T6174	2204-2206	IN	denotes	of
T6175	2207-2210	NNP	denotes	PKD
T6176	2211-2218	VBZ	denotes	enzymes
T6177	2218-2219	.	denotes	.
T6178	2220-2227	RB	denotes	However
T6179	2227-2228	,	denotes	,
T6180	2229-2241	NN	denotes	pretreatment
T6181	2242-2244	IN	denotes	of
T6182	2245-2249	DT	denotes	both
T6183	2250-2259	JJ	denotes	wild-type
T6184	2260-2263	CC	denotes	and
T6185	2264-2270	JJ	denotes	PKD1/3
T6186	2270-2271	NN	denotes	−
T6187	2271-2272	NN	denotes	/
T6188	2272-2273	NN	denotes	−
T6189	2274-2278	NNP	denotes	DT40
T6190	2279-2280	NNP	denotes	B
T6191	2281-2286	NNS	denotes	cells
T6192	2287-2291	IN	denotes	with
T6193	2292-2301	NNP	denotes	GF109203X
T6194	2301-2302	,	denotes	,
T6195	2303-2304	DT	denotes	a
T6196	2305-2323	NN	denotes	bisindoylmaleimide
T6197	2324-2334	NN	denotes	derivative
T6198	2335-2339	WDT	denotes	that
T6199	2340-2348	VBZ	denotes	inhibits
T6200	2349-2353	NNS	denotes	PKCs
T6201	2354-2363	VBD	denotes	prevented
T6202	2364-2367	DT	denotes	the
T6203	2368-2377	NN	denotes	induction
T6204	2378-2380	IN	denotes	of
T6205	2381-2389	NNS	denotes	proteins
T6206	2390-2394	WDT	denotes	that
T6207	2395-2402	VBP	denotes	contain
T6208	2403-2417	VBN	denotes	phosphorylated
T6209	2418-2426	NNP	denotes	LxRxxS/T
T6210	2427-2433	NNS	denotes	motifs
T6211	2433-2434	.	denotes	.
T6212	2435-2439	RB	denotes	Thus
T6213	2440-2444	NN	denotes	loss
T6214	2445-2447	IN	denotes	of
T6215	2448-2454	NNP	denotes	PKD1/3
T6216	2455-2462	VBZ	denotes	enzymes
T6217	2463-2467	VBZ	denotes	does
T6218	2468-2471	RB	denotes	not
T6219	2472-2480	RB	denotes	globally
T6220	2481-2488	VB	denotes	disrupt
T6221	2489-2492	DT	denotes	the
T6222	2493-2508	NN	denotes	phosphorylation
T6223	2509-2511	IN	denotes	of
T6224	2512-2520	JJ	denotes	cellular
T6225	2521-2529	NNS	denotes	proteins
T6226	2530-2534	WDT	denotes	that
T6227	2535-2542	VBP	denotes	contain
T6228	2543-2552	NNP	denotes	LxRxxpS/T
T6229	2553-2559	NNS	denotes	motifs
T6230	2559-2560	.	denotes	.
T6231	2561-2565	DT	denotes	This
T6232	2566-2572	NN	denotes	result
T6233	2573-2575	VBZ	denotes	is
T6234	2576-2583	RB	denotes	perhaps
T6235	2584-2587	RB	denotes	not
T6236	2588-2598	JJ	denotes	surprising
T6237	2599-2601	IN	denotes	as
T6238	2602-2610	NNP	denotes	LxRxxS/T
T6239	2611-2617	NNS	denotes	motifs
T6240	2618-2622	RB	denotes	also
T6241	2623-2626	VBP	denotes	act
T6242	2627-2629	RB	denotes	as
T6243	2630-2634	JJ	denotes	good
T6244	2635-2645	NNS	denotes	substrates
T6245	2646-2649	IN	denotes	for
T6246	2650-2655	JJ	denotes	other
T6247	2656-2672	JJ	denotes	serine/threonine
T6248	2673-2680	NNS	denotes	kinases
T6249	2681-2685	JJ	denotes	such
T6250	2686-2688	IN	denotes	as
T6251	2689-2697	NNP	denotes	MAPKAPK2
T6252	2697-2698	.	denotes	.
T6253	2699-2706	RB	denotes	However
T6254	2707-2712	DT	denotes	these
T6255	2713-2724	NNS	denotes	experiments
T6256	2725-2727	VBP	denotes	do
T6257	2728-2735	VB	denotes	provide
T6258	2736-2743	JJ	denotes	further
T6259	2744-2752	NN	denotes	evidence
T6260	2753-2757	IN	denotes	that
T6261	2758-2773	JJ	denotes	phosphospecific
T6262	2774-2782	NN	denotes	antisera
T6263	2783-2786	VBP	denotes	are
T6264	2787-2790	RB	denotes	not
T6265	2791-2803	RB	denotes	sufficiently
T6266	2804-2813	JJ	denotes	selective
T6267	2814-2816	TO	denotes	to
T6268	2817-2819	VB	denotes	be
T6269	2820-2830	VBN	denotes	designated
T6270	2831-2837	NN	denotes	kinase
T6271	2838-2846	JJ	denotes	specific
T6272	2847-2856	JJ	denotes	substrate
T6273	2857-2865	NN	denotes	antisera
T6274	2865-2866	.	denotes	.
T6275	2867-2878	JJ	denotes	BCR-induced
T6276	2879-2889	JJ	denotes	signalling
T6277	2890-2898	NNS	denotes	pathways
T6278	2899-2908	VBP	denotes	culminate
T6279	2909-2911	IN	denotes	in
T6280	2912-2915	DT	denotes	the
T6281	2916-2926	NN	denotes	activation
T6282	2927-2929	IN	denotes	of
T6283	2930-2934	NN	denotes	gene
T6284	2935-2948	NN	denotes	transcription
T6285	2949-2955	NNS	denotes	events
T6286	2956-2960	WDT	denotes	that
T6287	2961-2968	VBP	denotes	control
T6288	2969-2970	NNP	denotes	B
T6289	2971-2975	NN	denotes	cell
T6290	2976-2984	NN	denotes	survival
T6291	2984-2985	,	denotes	,
T6292	2986-2999	NN	denotes	proliferation
T6293	3000-3003	CC	denotes	and
T6294	3004-3012	NN	denotes	function
T6295	3012-3013	.	denotes	.
T6296	3014-3016	IN	denotes	In
T6297	3017-3021	DT	denotes	this
T6298	3022-3029	NN	denotes	context
T6299	3029-3030	,	denotes	,
T6300	3031-3033	PRP	denotes	it
T6301	3034-3037	VBZ	denotes	has
T6302	3038-3042	VBN	denotes	been
T6303	3043-3051	VBN	denotes	proposed
T6304	3052-3056	IN	denotes	that
T6305	3057-3060	NNP	denotes	PKD
T6306	3061-3067	NN	denotes	family
T6307	3068-3075	NNS	denotes	members
T6308	3076-3083	NN	denotes	control
T6309	3084-3086	IN	denotes	of
T6310	3087-3091	NN	denotes	gene
T6311	3092-3105	NN	denotes	transcription
T6312	3106-3113	IN	denotes	through
T6313	3114-3124	NN	denotes	activation
T6314	3125-3127	IN	denotes	of
T6315	3128-3131	DT	denotes	the
T6316	3132-3136	NNP	denotes	NFκB
T6317	3137-3150	NN	denotes	transcription
T6318	3151-3157	NN	denotes	factor
T6319	3157-3158	.	denotes	.
T6320	3159-3163	RB	denotes	Thus
T6321	3163-3164	,	denotes	,
T6322	3165-3177	JJ	denotes	PKD-mediated
T6323	3178-3188	NN	denotes	activation
T6324	3189-3191	IN	denotes	of
T6325	3192-3196	NNP	denotes	NFκB
T6326	3197-3203	VBZ	denotes	occurs
T6327	3204-3214	JJ	denotes	downstream
T6328	3215-3217	IN	denotes	of
T6329	3218-3219	DT	denotes	a
T6330	3220-3227	NN	denotes	variety
T6331	3228-3230	IN	denotes	of
T6332	3231-3240	JJ	denotes	different
T6333	3241-3248	NNS	denotes	signals
T6334	3248-3249	,	denotes	,
T6335	3250-3259	VBG	denotes	including
T6336	3260-3274	JJ	denotes	mROS/oxidative
T6337	3275-3281	NN	denotes	stress
T6338	3281-3282	,	denotes	,
T6339	3283-3299	JJ	denotes	lysophosphatidic
T6340	3300-3304	NN	denotes	acid
T6341	3305-3308	CC	denotes	and
T6342	3309-3312	DT	denotes	the
T6343	3313-3320	NNP	denotes	Bcr-Abl
T6344	3321-3329	NN	denotes	oncogene
T6345	3330-3331	NNP	denotes	[
T6346	3331-3345	CD	denotes	17,21,23,30,37
T6347	3345-3346	NNP	denotes	]
T6348	3346-3347	.	denotes	.
T6349	3348-3359	RB	denotes	Furthermore
T6350	3359-3360	,	denotes	,
T6351	3361-3371	NN	denotes	expression
T6352	3372-3374	IN	denotes	of
T6353	3375-3377	DT	denotes	an
T6354	3378-3387	VBN	denotes	activated
T6355	3388-3392	NNP	denotes	PKD1
T6356	3393-3399	JJ	denotes	mutant
T6357	3400-3408	VBZ	denotes	enhances
T6358	3409-3422	JJ	denotes	HPK1-mediated
T6359	3423-3427	NNP	denotes	NFκB
T6360	3428-3438	NN	denotes	activation
T6361	3439-3440	NNP	denotes	[
T6362	3440-3442	CD	denotes	38
T6363	3442-3443	NNP	denotes	]
T6364	3443-3444	.	denotes	.
T6365	3445-3447	IN	denotes	In
T6366	3448-3449	NNP	denotes	B
T6367	3450-3455	NNS	denotes	cells
T6368	3455-3456	,	denotes	,
T6369	3457-3461	NNP	denotes	NFκB
T6370	3462-3464	VBZ	denotes	is
T6371	3465-3470	VBN	denotes	known
T6372	3471-3473	TO	denotes	to
T6373	3474-3476	VB	denotes	be
T6374	3477-3486	VBN	denotes	regulated
T6375	3487-3490	IN	denotes	via
T6376	3491-3494	NNP	denotes	DAG
T6377	3495-3498	CC	denotes	and
T6378	3499-3503	NNP	denotes	PKCβ
T6379	3504-3505	NNP	denotes	[
T6380	3505-3510	CD	denotes	39,40
T6381	3510-3511	NNP	denotes	]
T6382	3512-3515	CC	denotes	but
T6383	3516-3523	IN	denotes	whether
T6384	3524-3528	NNS	denotes	PKDs
T6385	3529-3532	VBP	denotes	are
T6386	3533-3536	JJ	denotes	key
T6387	3537-3551	NNS	denotes	intermediaries
T6388	3552-3555	IN	denotes	for
T6389	3556-3560	NNP	denotes	NFκB
T6390	3561-3571	NN	denotes	regulation
T6391	3572-3575	VBZ	denotes	has
T6392	3576-3579	RB	denotes	not
T6393	3580-3584	VBN	denotes	been
T6394	3585-3593	VBN	denotes	explored
T6395	3593-3594	.	denotes	.
T6396	3595-3598	DT	denotes	The
T6397	3599-3603	NNS	denotes	data
T6398	3604-3605	-LRB-	denotes	(
T6399	3605-3609	NNP	denotes	Fig.
T6400	3610-3612	NNP	denotes	4A
T6401	3612-3613	-RRB-	denotes	)
T6402	3614-3618	VBP	denotes	show
T6403	3619-3623	IN	denotes	that
T6404	3624-3628	NNP	denotes	NFκB
T6405	3629-3644	JJ	denotes	transcriptional
T6406	3645-3653	NN	denotes	activity
T6407	3654-3657	VBD	denotes	was
T6408	3658-3666	RB	denotes	strongly
T6409	3667-3674	VBN	denotes	induced
T6410	3675-3677	IN	denotes	in
T6411	3678-3682	DT	denotes	both
T6412	3683-3692	JJ	denotes	wild-type
T6413	3693-3696	CC	denotes	and
T6414	3697-3703	JJ	denotes	PKD1/3
T6415	3703-3704	NN	denotes	−
T6416	3704-3705	NN	denotes	/
T6417	3705-3706	NN	denotes	−
T6418	3707-3711	NNP	denotes	DT40
T6419	3712-3713	NNP	denotes	B
T6420	3714-3719	NNS	denotes	cells
T6421	3720-3722	IN	denotes	in
T6422	3723-3731	NN	denotes	response
T6423	3732-3734	TO	denotes	to
T6424	3735-3741	DT	denotes	either
T6425	3742-3749	NN	denotes	phorbol
T6426	3750-3755	NN	denotes	ester
T6427	3756-3758	CC	denotes	or
T6428	3759-3762	NNP	denotes	BCR
T6429	3763-3774	NN	denotes	stimulation
T6430	3774-3775	.	denotes	.
T6431	3776-3778	IN	denotes	In
T6432	3779-3787	NN	denotes	contrast
T6433	3787-3788	,	denotes	,
T6434	3789-3792	NNP	denotes	BCR
T6435	3793-3796	CC	denotes	and
T6436	3797-3804	JJ	denotes	phorbol
T6437	3805-3818	JJ	denotes	ester-induced
T6438	3819-3823	NNP	denotes	NFκB
T6439	3824-3839	JJ	denotes	transcriptional
T6440	3840-3848	NN	denotes	activity
T6441	3849-3852	VBD	denotes	was
T6442	3853-3862	VBN	denotes	abolished
T6443	3863-3865	IN	denotes	in
T6444	3866-3870	NNP	denotes	PKCβ
T6445	3870-3871	NNP	denotes	−
T6446	3871-3872	NNP	denotes	/
T6447	3872-3873	NNP	denotes	−
T6448	3874-3878	NNP	denotes	DT40
T6449	3879-3880	NNP	denotes	B
T6450	3881-3886	NNS	denotes	cells
T6451	3887-3888	-LRB-	denotes	(
T6452	3888-3892	NNP	denotes	Fig.
T6453	3893-3895	NNP	denotes	4A
T6454	3895-3896	-RRB-	denotes	)
T6455	3896-3897	,	denotes	,
T6456	3898-3906	IN	denotes	although
T6457	3907-3913	JJ	denotes	strong
T6458	3914-3924	NN	denotes	activation
T6459	3925-3927	IN	denotes	of
T6460	3928-3931	NNP	denotes	PKD
T6461	3932-3939	NNS	denotes	kinases
T6462	3940-3941	-LRB-	denotes	(
T6463	3941-3943	IN	denotes	as
T6464	3944-3952	VBN	denotes	assessed
T6465	3953-3955	IN	denotes	by
T6466	3956-3975	NN	denotes	autophosphorylation
T6467	3976-3978	IN	denotes	of
T6468	3979-3983	NNP	denotes	PKD1
T6469	3984-3986	IN	denotes	at
T6470	3987-3991	NNP	denotes	S916
T6471	3991-3992	-RRB-	denotes	)
T6472	3993-3996	VBD	denotes	was
T6473	3997-4005	VBN	denotes	observed
T6474	4006-4008	IN	denotes	in
T6475	4009-4012	DT	denotes	the
T6476	4013-4017	NNP	denotes	PKCβ
T6477	4017-4018	NNP	denotes	−
T6478	4018-4019	VBD	denotes	/
T6479	4019-4020	CD	denotes	−
T6480	4021-4026	NNS	denotes	cells
T6481	4027-4028	-LRB-	denotes	(
T6482	4028-4032	NNP	denotes	Fig.
T6483	4033-4035	NNP	denotes	4B
T6484	4035-4036	-RRB-	denotes	)
T6485	4036-4037	.	denotes	.
T6486	4038-4042	RB	denotes	Thus
T6487	4042-4043	,	denotes	,
T6488	4044-4047	NNP	denotes	PKD
T6489	4048-4055	NNS	denotes	kinases
T6490	4056-4059	VBP	denotes	are
T6491	4060-4067	DT	denotes	neither
T6492	4068-4077	JJ	denotes	essential
T6493	4078-4081	CC	denotes	nor
T6494	4082-4092	JJ	denotes	sufficient
T6495	4093-4095	TO	denotes	to
T6496	4096-4103	VB	denotes	mediate
T6497	4104-4115	JJ	denotes	BCR-induced
T6498	4116-4120	NN	denotes	NFκB
T6499	4121-4131	NN	denotes	activation
T6500	4132-4134	IN	denotes	in
T6501	4135-4139	NNP	denotes	DT40
T6502	4140-4141	NNP	denotes	B
T6503	4142-4147	NNS	denotes	cells
T6504	4148-4151	CC	denotes	and
T6505	4152-4157	RB	denotes	hence
T6506	4158-4160	VBP	denotes	do
T6507	4161-4164	RB	denotes	not
T6508	4165-4176	VB	denotes	participate
T6509	4177-4179	IN	denotes	in
T6510	4180-4187	NNP	denotes	DAG/PKC
T6511	4188-4196	VBD	denotes	mediated
T6512	4197-4204	NN	denotes	control
T6513	4205-4207	IN	denotes	of
T6514	4208-4212	NNP	denotes	NFκB
T6515	4212-4213	.	denotes	.
R4622	T5769	T5770	compound	Antigen,receptor
R4623	T5770	T5773	amod	receptor,pathways
R4624	T5771	T5773	amod	regulated,pathways
R4625	T5772	T5773	amod	signalling,pathways
R4626	T5773	T5781	nsubj	pathways,explore
R4627	T5774	T5773	prep	in,pathways
R4628	T5775	T5777	compound	PKD-null,B
R4629	T5776	T5777	compound	DT40,B
R4630	T5777	T5778	compound	B,cells
R4631	T5778	T5774	pobj	cells,in
R4632	T5779	T5781	aux	To,explore
R4633	T5780	T5781	advmod	further,explore
R4634	T5781	T5781	ROOT	explore,explore
R4635	T5782	T5783	det	the,contribution
R4636	T5783	T5781	dobj	contribution,explore
R4637	T5784	T5783	prep	of,contribution
R4638	T5785	T5786	compound	PKD,kinases
R4639	T5786	T5784	pobj	kinases,of
R4640	T5787	T5786	prep	to,kinases
R4641	T5788	T5791	compound	DT40,biology
R4642	T5789	T5791	compound	B,biology
R4643	T5790	T5791	compound	cell,biology
R4644	T5791	T5787	pobj	biology,to
R4645	T5792	T5793	nsubj	we,investigated
R4646	T5793	T5783	relcl	investigated,contribution
R4647	T5794	T5799	mark	whether,were
R4648	T5795	T5798	amod	specific,events
R4649	T5796	T5798	amod	BCR-regulated,events
R4650	T5797	T5798	amod	signalling,events
R4651	T5798	T5799	nsubj	events,were
R4652	T5799	T5793	ccomp	were,investigated
R4653	T5800	T5799	acomp	defective,were
R4654	T5801	T5800	prep	in,defective
R4655	T5802	T5805	det	the,cells
R4656	T5803	T5804	compound	PKD-null,B
R4657	T5804	T5805	compound	B,cells
R4658	T5805	T5801	pobj	cells,in
R4659	T5806	T5781	punct	.,explore
R4660	T5807	T5808	amod	Initial,experiments
R4661	T5808	T5809	nsubj	experiments,revealed
R4662	T5809	T5809	ROOT	revealed,revealed
R4663	T5810	T5817	mark	that,reduced
R4664	T5811	T5812	compound	surface,expression
R4665	T5812	T5817	nsubjpass	expression,reduced
R4666	T5813	T5812	prep	of,expression
R4667	T5814	T5815	det	the,BCR
R4668	T5815	T5813	pobj	BCR,of
R4669	T5816	T5817	auxpass	was,reduced
R4670	T5817	T5809	ccomp	reduced,revealed
R4671	T5818	T5817	prep	in,reduced
R4672	T5819	T5822	nummod	PKD1/3,−
R4673	T5820	T5822	nummod	−,−
R4674	T5821	T5822	compound	/,−
R4675	T5822	T5818	pobj	−,in
R4676	T5823	T5822	punct	(,−
R4677	T5824	T5818	cc	and,in
R4678	T5825	T5817	prep	in,reduced
R4679	T5826	T5835	nummod	PKD1/3,cells
R4680	T5827	T5829	nummod	−,−
R4681	T5828	T5829	compound	/,−
R4682	T5829	T5835	nummod	−,cells
R4683	T5830	T5829	punct	:,−
R4684	T5831	T5829	appos	Flag-PKD3,−
R4685	T5832	T5833	advmod	+,ve
R4686	T5833	T5829	appos	ve,−
R4687	T5834	T5829	punct	),−
R4688	T5835	T5825	pobj	cells,in
R4689	T5836	T5817	prep	compared,reduced
R4690	T5837	T5836	prep	to,compared
R4691	T5838	T5841	amod	wild-type,cells
R4692	T5839	T5840	compound	DT40,B
R4693	T5840	T5841	compound	B,cells
R4694	T5841	T5837	pobj	cells,to
R4695	T5842	T5841	punct	(,cells
R4696	T5843	T5844	compound	Fig.,3A
R4697	T5844	T5841	appos	3A,cells
R4698	T5845	T5844	cc	and,3A
R4699	T5846	T5848	nsubj	data,shown
R4700	T5847	T5848	neg	not,shown
R4701	T5848	T5841	relcl	shown,cells
R4702	T5849	T5817	punct	),reduced
R4703	T5850	T5809	punct	.,revealed
R4704	T5851	T5860	advmod	Nevertheless,was
R4705	T5852	T5860	punct	",",was
R4706	T5853	T5860	nsubj	BCR-crosslinking,was
R4707	T5854	T5853	prep	of,BCR-crosslinking
R4708	T5855	T5859	nummod	PKD1/3,cells
R4709	T5856	T5859	nummod	−,cells
R4710	T5857	T5859	nmod	/,cells
R4711	T5858	T5859	amod	−,cells
R4712	T5859	T5854	pobj	cells,of
R4713	T5860	T5860	ROOT	was,was
R4714	T5861	T5860	acomp	sufficient,was
R4715	T5862	T5863	aux	to,induce
R4716	T5863	T5861	xcomp	induce,sufficient
R4717	T5864	T5865	det	the,activation
R4718	T5865	T5863	dobj	activation,induce
R4719	T5866	T5865	prep	of,activation
R4720	T5867	T5868	det	a,number
R4721	T5868	T5866	pobj	number,of
R4722	T5869	T5868	prep	of,number
R4723	T5870	T5869	pcomp	signalling,of
R4724	T5871	T5870	dobj	cascades,signalling
R4725	T5872	T5871	punct	",",cascades
R4726	T5873	T5871	amod	similar,cascades
R4727	T5874	T5873	prep	to,similar
R4728	T5875	T5876	nsubj	that,observed
R4729	T5876	T5871	relcl	observed,cascades
R4730	T5877	T5876	prep	in,observed
R4731	T5878	T5879	amod	wild-type,cells
R4732	T5879	T5877	pobj	cells,in
R4733	T5880	T5871	punct	(,cascades
R4734	T5881	T5882	compound	Fig.,3B
R4735	T5882	T5871	appos	3B,cascades
R4736	T5883	T5871	punct	),cascades
R4737	T5884	T5860	punct	.,was
R4738	T5885	T5888	advmod	Hence,activation
R4739	T5886	T5888	punct	",",activation
R4740	T5887	T5888	amod	BCR-induced,activation
R4741	T5888	T5909	nsubj	activation,was
R4742	T5889	T5888	prep	of,activation
R4743	T5890	T5891	det	the,Akt
R4744	T5891	T5889	pobj	Akt,of
R4745	T5892	T5891	punct	",",Akt
R4746	T5893	T5895	compound	mTOR/p70,kinase
R4747	T5894	T5895	compound	S6,kinase
R4748	T5895	T5891	appos	kinase,Akt
R4749	T5896	T5898	punct	(,shown
R4750	T5897	T5898	mark	as,shown
R4751	T5898	T5888	advcl	shown,activation
R4752	T5899	T5898	agent	by,shown
R4753	T5900	T5908	nummod	S6,pathways
R4754	T5901	T5902	amod	ribosomal,protein
R4755	T5902	T5908	nmod	protein,pathways
R4756	T5903	T5902	appos	phosphorylation,protein
R4757	T5904	T5902	punct	),protein
R4758	T5905	T5902	cc	and,protein
R4759	T5906	T5902	conj	MAPK,protein
R4760	T5907	T5908	amod	signalling,pathways
R4761	T5908	T5899	pobj	pathways,by
R4762	T5909	T5909	ROOT	was,was
R4763	T5910	T5909	advmod	clearly,was
R4764	T5911	T5909	acomp	detectable,was
R4765	T5912	T5911	prep	in,detectable
R4766	T5913	T5914	compound	PKD1/3-null,B
R4767	T5914	T5915	compound	B,cells
R4768	T5915	T5912	pobj	cells,in
R4769	T5916	T5918	punct	(,3B
R4770	T5917	T5918	compound	Fig.,3B
R4771	T5918	T5911	appos	3B,detectable
R4772	T5919	T5918	punct	),3B
R4773	T5920	T5909	punct	.,was
R4774	T5921	T5941	advmod	Furthermore,observed
R4775	T5922	T5941	punct	",",observed
R4776	T5923	T5925	amod	enhanced,phosphorylation
R4777	T5924	T5925	compound	tyrosine,phosphorylation
R4778	T5925	T5941	nsubjpass	phosphorylation,observed
R4779	T5926	T5925	prep	of,phosphorylation
R4780	T5927	T5929	amod	multiple,proteins
R4781	T5928	T5929	amod	cellular,proteins
R4782	T5929	T5926	pobj	proteins,of
R4783	T5930	T5932	advmod	as,as
R4784	T5931	T5932	advmod	well,as
R4785	T5932	T5925	cc	as,phosphorylation
R4786	T5933	T5934	det	an,increase
R4787	T5934	T5925	conj	increase,phosphorylation
R4788	T5935	T5934	prep	in,increase
R4789	T5936	T5938	amod	intracellular,levels
R4790	T5937	T5938	compound	calcium,levels
R4791	T5938	T5935	pobj	levels,in
R4792	T5939	T5941	auxpass	was,observed
R4793	T5940	T5941	advmod	also,observed
R4794	T5941	T5941	ROOT	observed,observed
R4795	T5942	T5941	prep	following,observed
R4796	T5943	T5944	compound	BCR,stimulation
R4797	T5944	T5942	pobj	stimulation,following
R4798	T5945	T5944	prep	of,stimulation
R4799	T5946	T5948	nmod	PKD1/3-null,cells
R4800	T5947	T5948	compound	B,cells
R4801	T5948	T5945	pobj	cells,of
R4802	T5949	T5950	punct	(,data
R4803	T5950	T5948	appos	data,cells
R4804	T5951	T5952	neg	not,shown
R4805	T5952	T5950	acl	shown,data
R4806	T5953	T5950	punct	),data
R4807	T5954	T5941	punct	.,observed
R4808	T5955	T5957	nsubj	We,observe
R4809	T5956	T5957	aux	did,observe
R4810	T5957	T5957	ROOT	observe,observe
R4811	T5958	T5970	mark	that,induced
R4812	T5959	T5960	det	the,strength
R4813	T5960	T5970	nsubj	strength,induced
R4814	T5961	T5960	prep	of,strength
R4815	T5962	T5961	pobj	BCR,of
R4816	T5963	T5960	punct	(,strength
R4817	T5964	T5960	cc	but,strength
R4818	T5965	T5966	neg	not,phorbol
R4819	T5966	T5967	advmod	phorbol,ester
R4820	T5967	T5960	conj	ester,strength
R4821	T5968	T5960	punct	),strength
R4822	T5969	T5970	punct	-,induced
R4823	T5970	T5957	ccomp	induced,observe
R4824	T5971	T5970	dobj	regulation,induced
R4825	T5972	T5971	prep	of,regulation
R4826	T5973	T5976	det	the,pathway
R4827	T5974	T5976	amod	Erk1-RSK1,pathway
R4828	T5975	T5976	compound	signalling,pathway
R4829	T5976	T5972	pobj	pathway,of
R4830	T5977	T5978	auxpass	was,reduced
R4831	T5978	T5970	conj	reduced,induced
R4832	T5979	T5978	prep	in,reduced
R4833	T5980	T5985	nummod	PKD1/3,cells
R4834	T5981	T5985	nummod	−,cells
R4835	T5982	T5985	compound	/,cells
R4836	T5983	T5985	compound	−,cells
R4837	T5984	T5985	compound	B,cells
R4838	T5985	T5979	pobj	cells,in
R4839	T5986	T5978	prep	compared,reduced
R4840	T5987	T5986	prep	to,compared
R4841	T5988	T5990	amod	wild-type,cells
R4842	T5989	T5990	compound	B,cells
R4843	T5990	T5987	pobj	cells,to
R4844	T5991	T5993	punct	(,3B
R4845	T5992	T5993	compound	Fig.,3B
R4846	T5993	T5990	appos	3B,cells
R4847	T5994	T5990	punct	),cells
R4848	T5995	T5957	punct	.,observe
R4849	T5996	T5997	nummod	One,interpretation
R4854	T6001	T6001	ROOT	is,is
R4855	T6002	T6006	mark	that,modulate
R4856	T6003	T6004	compound	PKD,enzymes
R4857	T6004	T6006	nsubj	enzymes,modulate
R4858	T6005	T6006	aux	may,modulate
R4859	T6006	T6001	ccomp	modulate,is
R4860	T6007	T6008	compound	Erk,activation
R4861	T6008	T6006	dobj	activation,modulate
R4862	T6009	T6001	punct	.,is
R4863	T6010	T6017	advmod	Indeed,linked
R4864	T6011	T6017	punct	",",linked
R4865	T6012	T6013	compound	PKD,enzymes
R4866	T6013	T6017	nsubj	enzymes,linked
R4867	T6014	T6017	aux	have,linked
R4868	T6015	T6017	advmod	previously,linked
R4869	T6016	T6017	auxpass	been,linked
R4870	T6017	T6017	ROOT	linked,linked
R4871	T6018	T6017	prep	to,linked
R4872	T6019	T6020	det	the,growth
R4873	T6020	T6018	pobj	growth,to
R4874	T6021	T6023	amod	factor-regulated,signalling
R4875	T6022	T6023	compound	Erk,signalling
R4876	T6023	T6017	dobj	signalling,linked
R4877	T6024	T6023	prep	in,signalling
R4878	T6025	T6029	nmod	fibroblast,lines
R4879	T6026	T6025	cc	and,fibroblast
R4880	T6027	T6029	amod	endothelial,lines
R4881	T6028	T6029	compound	cell,lines
R4882	T6029	T6024	pobj	lines,in
R4883	T6030	T6023	dobj	[,signalling
R4884	T6031	T6030	nummod	33,[
R4885	T6032	T6033	nummod	35,]
R4886	T6033	T6030	appos	],[
R4887	T6034	T6017	punct	.,linked
R4888	T6035	T6042	advmod	However,reduced
R4889	T6036	T6042	punct	",",reduced
R4890	T6037	T6039	amod	BCR-induced,phosphorylation
R4891	T6038	T6039	compound	Erk,phosphorylation
R4892	T6039	T6042	nsubjpass	phosphorylation,reduced
R4893	T6040	T6042	auxpass	was,reduced
R4894	T6041	T6042	advmod	also,reduced
R4895	T6042	T6042	ROOT	reduced,reduced
R4896	T6043	T6042	prep	in,reduced
R4897	T6044	T6052	nummod	PKD1/3,cells
R4898	T6045	T6046	nummod	−,/
R4899	T6046	T6052	compound	/,cells
R4900	T6047	T6049	punct	−,Flag-PKD3
R4901	T6048	T6049	punct	-,Flag-PKD3
R4902	T6049	T6052	compound	Flag-PKD3,cells
R4903	T6050	T6052	compound	+,cells
R4904	T6051	T6052	compound	B,cells
R4905	T6052	T6043	pobj	cells,in
R4906	T6053	T6052	punct	(,cells
R4907	T6054	T6054	ROOT	data,data
R4908	T6055	T6056	neg	not,shown
R4909	T6056	T6054	acl	shown,data
R4910	T6057	T6054	punct	),data
R4911	T6058	T6042	advcl	suggesting,reduced
R4912	T6059	T6074	mark	that,−
R4913	T6060	T6062	amod	reduced,levels
R4914	T6061	T6062	compound	BCR,levels
R4915	T6062	T6074	nsubj	levels,−
R4916	T6063	T6062	prep	on,levels
R4917	T6064	T6065	det	the,surface
R4918	T6065	T6063	pobj	surface,on
R4919	T6066	T6065	prep	of,surface
R4920	T6067	T6070	nummod	PKD1/3,−
R4921	T6068	T6070	nummod	−,−
R4922	T6069	T6070	compound	/,−
R4923	T6070	T6066	pobj	−,of
R4924	T6071	T6070	punct	(,−
R4925	T6072	T6070	cc	and,−
R4926	T6073	T6074	nsubj	PKD1/3,−
R4927	T6074	T6058	ccomp	−,suggesting
R4928	T6075	T6079	nummod	/,+
R4929	T6076	T6078	punct	−,Flag-PKD3
R4930	T6077	T6078	punct	-,Flag-PKD3
R4939	T6086	T6085	prep	on,impact
R4940	T6087	T6088	det	the,strength
R4941	T6088	T6086	pobj	strength,on
R4942	T6089	T6088	prep	of,strength
R4943	T6090	T6089	pobj	activation,of
R4944	T6091	T6090	prep	of,activation
R4945	T6092	T6096	det	this,pathway
R4946	T6093	T6096	amod	specific,pathway
R4947	T6094	T6096	amod	intracellular,pathway
R4948	T6095	T6096	compound	signalling,pathway
R4949	T6096	T6091	pobj	pathway,of
R4950	T6097	T6085	punct	.,impact
R4951	T6098	T6099	aux	To,search
R4952	T6099	T6120	advcl	search,used
R4953	T6100	T6099	prep	for,search
R4954	T6101	T6104	amod	other,targets
R4955	T6102	T6104	amod	potential,targets
R4956	T6103	T6104	compound	PKD,targets
R4957	T6104	T6100	pobj	targets,for
R4958	T6105	T6107	nsubj	that,show
R4959	T6106	T6107	aux	may,show
R4960	T6107	T6104	relcl	show,targets
R4961	T6108	T6109	amod	defective,regulation
R4962	T6109	T6107	dobj	regulation,show
R4963	T6110	T6109	prep	in,regulation
R4964	T6111	T6116	compound	PKD1/3,B
R4965	T6112	T6116	compound	−,B
R4966	T6113	T6116	compound	/,B
R4967	T6114	T6116	compound	−,B
R4968	T6115	T6116	compound	DT40,B
R4969	T6116	T6117	compound	B,cells
R4970	T6117	T6110	pobj	cells,in
R4971	T6118	T6120	punct	",",used
R4972	T6119	T6120	nsubj	we,used
R4973	T6120	T6120	ROOT	used,used
R4974	T6121	T6123	det	a,substrate
R4975	T6122	T6123	compound	PKD,substrate
R4976	T6123	T6120	dobj	substrate,used
R4977	T6124	T6123	amod	phospho-antibody,substrate
R4978	T6125	T6126	nsubj	that,recognises
R4979	T6126	T6124	relcl	recognises,phospho-antibody
R4980	T6127	T6129	compound	consensus,sequences
R4981	T6128	T6129	compound	phosphorylation,sequences
R4982	T6129	T6126	dobj	sequences,recognises
R4983	T6130	T6129	acl	targeted,sequences
R4984	T6131	T6130	agent	by,targeted
R4985	T6132	T6133	compound	PKD,enzymes
R4986	T6133	T6131	pobj	enzymes,by
R4987	T6134	T6137	punct	(,[
R4988	T6135	T6137	nmod	LxRxxpS/T,[
R4989	T6136	T6137	punct	),[
R4990	T6137	T6133	appos	[,enzymes
R4991	T6138	T6139	nummod	36,]
R4992	T6139	T6137	appos	],[
R4993	T6140	T6120	punct	.,used
R4994	T6141	T6142	mark	As,shown
R4995	T6142	T6160	advcl	shown,was
R4996	T6143	T6142	prep	in,shown
R4997	T6144	T6145	compound	Fig.,3C
R4998	T6145	T6143	pobj	3C,in
R4999	T6146	T6145	punct	",",3C
R5000	T6147	T6160	nsubj	phorbol,was
R5001	T6148	T6160	nsubj	ester,was
R5002	T6149	T6148	punct	-,ester
R5003	T6150	T6148	cc	and,ester
R5004	T6151	T6152	amod	BCR-induced,phosphorylation
R5005	T6152	T6148	conj	phosphorylation,ester
R5006	T6153	T6152	prep	of,phosphorylation
R5007	T6154	T6155	amod	cellular,substrates
R5008	T6155	T6153	pobj	substrates,of
R5009	T6156	T6155	acl	detected,substrates
R5010	T6157	T6156	agent	by,detected
R5011	T6158	T6159	det	this,phospho-antibody
R5012	T6159	T6157	pobj	phospho-antibody,by
R5013	T6160	T6160	ROOT	was,was
R5014	T6161	T6160	acomp	similar,was
R5015	T6162	T6161	prep	in,similar
R5016	T6163	T6169	amod	wild-type,cells
R5017	T6164	T6163	cc	and,wild-type
R5018	T6165	T6163	conj	PKD1/3,wild-type
R5019	T6166	T6169	compound	−,cells
R5020	T6167	T6169	compound	/,cells
R5021	T6168	T6169	compound	−,cells
R5022	T6169	T6162	pobj	cells,in
R5023	T6170	T6160	cc	and,was
R5024	T6171	T6160	conj	is,was
R5025	T6172	T6173	advmod	therefore,independent
R5026	T6173	T6171	acomp	independent,is
R5027	T6174	T6173	prep	of,independent
R5028	T6175	T6176	compound	PKD,enzymes
R5029	T6176	T6174	pobj	enzymes,of
R5030	T6177	T6171	punct	.,is
R5031	T6178	T6201	advmod	However,prevented
R5032	T6179	T6201	punct	",",prevented
R5033	T6180	T6201	nsubj	pretreatment,prevented
R5034	T6181	T6180	prep	of,pretreatment
R5035	T6182	T6183	preconj	both,wild-type
R5036	T6183	T6181	pobj	wild-type,of
R5037	T6184	T6183	cc	and,wild-type
R5038	T6185	T6183	conj	PKD1/3,wild-type
R5039	T6186	T6188	compound	−,−
R5040	T6187	T6188	compound	/,−
R5041	T6188	T6191	compound	−,cells
R5042	T6189	T6190	compound	DT40,B
R5043	T6190	T6191	compound	B,cells
R5044	T6191	T6183	appos	cells,wild-type
R5045	T6192	T6180	prep	with,pretreatment
R5046	T6193	T6192	pobj	GF109203X,with
R5047	T6194	T6193	punct	",",GF109203X
R5048	T6195	T6197	det	a,derivative
R5049	T6196	T6197	compound	bisindoylmaleimide,derivative
R5050	T6197	T6193	appos	derivative,GF109203X
R5051	T6198	T6199	nsubj	that,inhibits
R5052	T6199	T6197	relcl	inhibits,derivative
R5053	T6200	T6199	dobj	PKCs,inhibits
R5054	T6201	T6201	ROOT	prevented,prevented
R5055	T6202	T6203	det	the,induction
R5056	T6203	T6201	dobj	induction,prevented
R5057	T6204	T6203	prep	of,induction
R5058	T6205	T6204	pobj	proteins,of
R5059	T6206	T6207	nsubj	that,contain
R5060	T6207	T6205	relcl	contain,proteins
R5061	T6208	T6209	compound	phosphorylated,LxRxxS/T
R5062	T6209	T6210	compound	LxRxxS/T,motifs
R5063	T6210	T6207	dobj	motifs,contain
R5064	T6211	T6201	punct	.,prevented
R5065	T6212	T6216	advmod	Thus,enzymes
R5066	T6213	T6216	nsubj	loss,enzymes
R5067	T6214	T6213	prep	of,loss
R5068	T6215	T6214	pobj	PKD1/3,of
R5069	T6216	T6220	nsubj	enzymes,disrupt
R5070	T6217	T6220	aux	does,disrupt
R5071	T6218	T6220	neg	not,disrupt
R5072	T6219	T6220	advmod	globally,disrupt
R5073	T6220	T6220	ROOT	disrupt,disrupt
R5074	T6221	T6222	det	the,phosphorylation
R5075	T6222	T6220	dobj	phosphorylation,disrupt
R5076	T6223	T6222	prep	of,phosphorylation
R5077	T6224	T6225	amod	cellular,proteins
R5078	T6225	T6223	pobj	proteins,of
R5132	T6279	T6278	prep	in,culminate
R5133	T6280	T6281	det	the,activation
R5134	T6281	T6279	pobj	activation,in
R5135	T6282	T6281	prep	of,activation
R5136	T6283	T6284	compound	gene,transcription
R5137	T6284	T6285	compound	transcription,events
R5138	T6285	T6282	pobj	events,of
R5139	T6286	T6287	nsubj	that,control
R5140	T6287	T6285	relcl	control,events
R5141	T6288	T6290	compound	B,survival
R5142	T6289	T6290	compound	cell,survival
R5143	T6290	T6287	dobj	survival,control
R5144	T6291	T6290	punct	",",survival
R5145	T6292	T6290	conj	proliferation,survival
R5146	T6293	T6292	cc	and,proliferation
R5147	T6294	T6292	conj	function,proliferation
R5148	T6295	T6278	punct	.,culminate
R5149	T6296	T6303	prep	In,proposed
R5150	T6297	T6298	det	this,context
R5151	T6298	T6296	pobj	context,In
R5152	T6299	T6303	punct	",",proposed
R5153	T6300	T6303	nsubjpass	it,proposed
R5154	T6301	T6303	aux	has,proposed
R5155	T6302	T6303	auxpass	been,proposed
R5156	T6303	T6303	ROOT	proposed,proposed
R5157	T6304	T6303	dobj	that,proposed
R5158	T6305	T6307	compound	PKD,members
R5159	T6306	T6307	compound	family,members
R5160	T6307	T6304	nsubj	members,that
R5161	T6308	T6307	dobj	control,members
R5162	T6309	T6308	prep	of,control
R5163	T6310	T6311	compound	gene,transcription
R5164	T6311	T6309	pobj	transcription,of
R5165	T6312	T6307	prep	through,members
R5166	T6313	T6312	pobj	activation,through
R5167	T6314	T6313	prep	of,activation
R5168	T6315	T6318	det	the,factor
R5169	T6316	T6318	compound	NFκB,factor
R5170	T6317	T6318	compound	transcription,factor
R5171	T6318	T6314	pobj	factor,of
R5172	T6319	T6303	punct	.,proposed
R5173	T6320	T6326	advmod	Thus,occurs
R5174	T6321	T6326	punct	",",occurs
R5175	T6322	T6323	amod	PKD-mediated,activation
R5176	T6323	T6326	nsubj	activation,occurs
R5177	T6324	T6323	prep	of,activation
R5178	T6325	T6324	pobj	NFκB,of
R5179	T6326	T6326	ROOT	occurs,occurs
R5180	T6327	T6326	advmod	downstream,occurs
R5181	T6328	T6327	prep	of,downstream
R5182	T6329	T6330	det	a,variety
R5183	T6330	T6328	pobj	variety,of
R5184	T6331	T6330	prep	of,variety
R5185	T6332	T6333	amod	different,signals
R5186	T6333	T6331	pobj	signals,of
R5187	T6334	T6333	punct	",",signals
R5188	T6335	T6333	prep	including,signals
R5189	T6336	T6337	amod	mROS/oxidative,stress
R5190	T6337	T6335	pobj	stress,including
R5191	T6338	T6337	punct	",",stress
R5192	T6339	T6340	amod	lysophosphatidic,acid
R5193	T6340	T6337	conj	acid,stress
R5194	T6341	T6340	cc	and,acid
R5195	T6342	T6344	det	the,oncogene
R5196	T6343	T6344	compound	Bcr-Abl,oncogene
R5197	T6344	T6340	conj	oncogene,acid
R5198	T6345	T6347	compound	[,]
R5199	T6346	T6347	compound	"17,21,23,30,37",]
R5200	T6347	T6344	appos	],oncogene
R5201	T6348	T6326	punct	.,occurs
R5202	T6349	T6357	advmod	Furthermore,enhances
R5203	T6350	T6351	punct	",",expression
R5204	T6351	T6357	nsubj	expression,enhances
R5205	T6352	T6351	prep	of,expression
R5206	T6353	T6356	det	an,mutant
R5207	T6354	T6356	amod	activated,mutant
R5208	T6355	T6356	compound	PKD1,mutant
R5209	T6356	T6352	pobj	mutant,of
R5210	T6357	T6357	ROOT	enhances,enhances
R5211	T6358	T6360	amod	HPK1-mediated,activation
R5212	T6359	T6360	compound	NFκB,activation
R5213	T6360	T6357	dobj	activation,enhances
R5214	T6361	T6363	nmod	[,]
R5215	T6362	T6363	nummod	38,]
R5216	T6363	T6357	npadvmod	],enhances
R5217	T6364	T6357	punct	.,enhances
R5218	T6365	T6371	prep	In,known
R5219	T6366	T6367	compound	B,cells
R5220	T6367	T6365	pobj	cells,In
R5221	T6368	T6371	punct	",",known
R5222	T6369	T6371	nsubjpass	NFκB,known
R5223	T6370	T6371	auxpass	is,known
R5224	T6371	T6371	ROOT	known,known
R5225	T6372	T6374	aux	to,regulated
R5226	T6373	T6374	auxpass	be,regulated
R5227	T6374	T6371	xcomp	regulated,known
R5228	T6375	T6374	prep	via,regulated
R5229	T6376	T6375	pobj	DAG,via
R5230	T6377	T6376	cc	and,DAG
R5231	T6378	T6379	compound	PKCβ,[
R5232	T6379	T6376	conj	[,DAG
R5233	T6380	T6381	compound	"39,40",]
R5234	T6381	T6376	conj	],DAG
R5235	T6382	T6371	cc	but,known
R5236	T6383	T6385	mark	whether,are
R5237	T6384	T6385	nsubj	PKDs,are
R5238	T6385	T6371	conj	are,known
R5239	T6386	T6387	amod	key,intermediaries
R5240	T6387	T6385	attr	intermediaries,are
R5241	T6388	T6385	prep	for,are
R5242	T6389	T6390	compound	NFκB,regulation
R5243	T6406	T6409	nsubjpass	activity,induced
R5244	T6390	T6388	pobj	regulation,for
R5245	T6407	T6409	auxpass	was,induced
R5246	T6408	T6409	advmod	strongly,induced
R5247	T6391	T6394	aux	has,explored
R5248	T6409	T6402	ccomp	induced,show
R5249	T6410	T6409	prep	in,induced
R5250	T6392	T6394	neg	not,explored
R5251	T6411	T6412	preconj	both,wild-type
R5252	T6393	T6394	auxpass	been,explored
R5253	T6412	T6417	nmod	wild-type,−
R5254	T6394	T6385	conj	explored,are
R5255	T6413	T6412	cc	and,wild-type
R5256	T6414	T6412	conj	PKD1/3,wild-type
R5257	T6415	T6417	compound	−,−
R5258	T6395	T6371	punct	.,known
R5259	T6416	T6417	compound	/,−
R5260	T6417	T6420	compound	−,cells
R5261	T6418	T6419	compound	DT40,B
R5262	T6396	T6397	det	The,data
R5263	T6419	T6420	compound	B,cells
R5264	T6420	T6410	pobj	cells,in
R5265	T6421	T6409	prep	in,induced
R5266	T6397	T6402	nsubj	data,show
R5267	T6422	T6421	pobj	response,in
R5268	T6423	T6422	prep	to,response
R5269	T6398	T6397	punct	(,data
R5270	T6424	T6426	preconj	either,ester
R5271	T6425	T6426	compound	phorbol,ester
R5272	T6399	T6400	compound	Fig.,4A
R5273	T6426	T6423	pobj	ester,to
R5274	T6427	T6426	cc	or,ester
R5275	T6428	T6429	compound	BCR,stimulation
R5276	T6429	T6426	conj	stimulation,ester
R5277	T6430	T6402	punct	.,show
R5278	T6431	T6442	prep	In,abolished
R5279	T6432	T6431	pobj	contrast,In
R5280	T6400	T6397	appos	4A,data
R5281	T6433	T6442	punct	",",abolished
R5282	T6434	T6440	nmod	BCR,activity
R5283	T6401	T6397	punct	),data
R5284	T6435	T6434	cc	and,BCR
R5285	T6436	T6440	amod	phorbol,activity
R5286	T6437	T6440	amod	ester-induced,activity
R5287	T6438	T6440	nmod	NFκB,activity
R5288	T6439	T6440	amod	transcriptional,activity
R5289	T6402	T6402	ROOT	show,show
R5290	T6440	T6442	nsubjpass	activity,abolished
R5291	T6441	T6442	auxpass	was,abolished
R5292	T6403	T6409	mark	that,induced
R5293	T6442	T6442	ROOT	abolished,abolished
R5294	T6443	T6442	prep	in,abolished
R5295	T6444	T6449	compound	PKCβ,B
R5296	T6404	T6406	nmod	NFκB,activity
R5297	T6445	T6449	compound	−,B
R5298	T6446	T6449	compound	/,B
R5299	T6447	T6449	compound	−,B
R5300	T6405	T6406	amod	transcriptional,activity
R5301	T6448	T6449	compound	DT40,B
R5302	T6449	T6450	compound	B,cells
R5304	T6450	T6443	pobj	cells,in
R5305	T6451	T6442	punct	(,abolished
R4850	T5997	T6001	nsubj	interpretation,is
R4851	T5998	T5997	prep	of,interpretation
R4852	T5999	T6000	det	this,data
R4853	T6000	T5998	pobj	data,of
R4931	T6078	T6079	compound	Flag-PKD3,+
R4932	T6079	T6074	appos	+,−
R4933	T6080	T6074	punct	),−
R4934	T6081	T6082	amod	B,cells
R4935	T6082	T6085	nsubj	cells,impact
R4936	T6083	T6085	aux	may,impact
R4937	T6084	T6085	nsubj	itself,impact
R4938	T6085	T6085	ROOT	impact,impact
R5079	T6226	T6227	nsubj	that,contain
R5080	T6227	T6225	relcl	contain,proteins
R5081	T6228	T6229	compound	LxRxxpS/T,motifs
R5082	T6229	T6227	dobj	motifs,contain
R5083	T6230	T6220	punct	.,disrupt
R5084	T6231	T6232	det	This,result
R5085	T6232	T6233	nsubj	result,is
R5086	T6233	T6233	ROOT	is,is
R5087	T6234	T6236	advmod	perhaps,surprising
R5088	T6235	T6236	neg	not,surprising
R5089	T6236	T6233	acomp	surprising,is
R5090	T6237	T6241	mark	as,act
R5091	T6238	T6239	compound	LxRxxS/T,motifs
R5092	T6239	T6241	nsubj	motifs,act
R5093	T6240	T6241	advmod	also,act
R5094	T6241	T6236	advcl	act,surprising
R5095	T6242	T6241	prep	as,act
R5096	T6243	T6244	amod	good,substrates
R5097	T6244	T6242	pobj	substrates,as
R5098	T6245	T6244	prep	for,substrates
R5099	T6246	T6248	amod	other,kinases
R5100	T6247	T6248	amod	serine/threonine,kinases
R5101	T6248	T6245	pobj	kinases,for
R5102	T6249	T6250	amod	such,as
R5103	T6250	T6248	prep	as,kinases
R5104	T6251	T6250	pobj	MAPKAPK2,as
R5105	T6252	T6233	punct	.,is
R5106	T6253	T6257	advmod	However,provide
R5107	T6254	T6255	det	these,experiments
R5108	T6255	T6257	nsubj	experiments,provide
R5109	T6256	T6257	aux	do,provide
R5110	T6257	T6257	ROOT	provide,provide
R5111	T6258	T6259	amod	further,evidence
R5112	T6259	T6257	dobj	evidence,provide
R5113	T6260	T6263	mark	that,are
R5114	T6261	T6262	amod	phosphospecific,antisera
R5115	T6262	T6263	nsubj	antisera,are
R5116	T6263	T6259	acl	are,evidence
R5117	T6264	T6263	neg	not,are
R5118	T6265	T6266	advmod	sufficiently,selective
R5119	T6266	T6263	acomp	selective,are
R5120	T6267	T6269	aux	to,designated
R5121	T6268	T6269	auxpass	be,designated
R5122	T6269	T6266	xcomp	designated,selective
R5123	T6270	T6269	oprd	kinase,designated
R5124	T6271	T6273	amod	specific,antisera
R5125	T6272	T6273	compound	substrate,antisera
R5126	T6273	T6270	appos	antisera,kinase
R5127	T6274	T6257	punct	.,provide
R5128	T6275	T6277	amod	BCR-induced,pathways
R5129	T6276	T6277	amod	signalling,pathways
R5130	T6277	T6278	nsubj	pathways,culminate
R5131	T6278	T6278	ROOT	culminate,culminate
R5308	T6452	T6453	compound	Fig.,4A
R5310	T6453	T6442	npadvmod	4A,abolished
R5311	T6454	T6442	punct	),abolished
R5312	T6455	T6442	punct	",",abolished
R5313	T6456	T6473	mark	although,observed
R5315	T6457	T6458	amod	strong,activation
R5316	T6458	T6473	nsubjpass	activation,observed
R5318	T6459	T6458	prep	of,activation
R5319	T6460	T6461	compound	PKD,kinases
R5320	T6461	T6459	pobj	kinases,of
R5322	T6462	T6464	punct	(,assessed
R5323	T6463	T6464	mark	as,assessed
R5325	T6464	T6473	advcl	assessed,observed
R5326	T6465	T6464	agent	by,assessed
R5327	T6466	T6465	pobj	autophosphorylation,by
R5328	T6467	T6466	prep	of,autophosphorylation
R5329	T6468	T6467	pobj	PKD1,of
R5330	T6469	T6466	prep	at,autophosphorylation
R5331	T6470	T6469	pobj	S916,at
R5332	T6471	T6464	punct	),assessed
R5333	T6472	T6473	auxpass	was,observed
R5335	T6473	T6442	advcl	observed,abolished
R5336	T6474	T6473	prep	in,observed
R5338	T6475	T6477	det	the,−
R5339	T6476	T6477	compound	PKCβ,−
R5340	T6477	T6474	pobj	−,in
R5341	T6478	T6442	conj	/,abolished
R5343	T6479	T6480	nummod	−,cells
R5344	T6480	T6478	dobj	cells,/
R5345	T6481	T6483	punct	(,4B
R5347	T6482	T6483	compound	Fig.,4B
R5348	T6483	T6478	parataxis	4B,/
R5349	T6484	T6483	punct	),4B
R5351	T6485	T6442	punct	.,abolished
R5303	T6503	T6500	pobj	cells,in
R5306	T6504	T6496	cc	and,mediate
R5307	T6505	T6508	advmod	hence,participate
R5309	T6506	T6508	aux	do,participate
R5314	T6507	T6508	neg	not,participate
R5317	T6508	T6496	conj	participate,mediate
R5321	T6509	T6508	prep	in,participate
R5324	T6510	T6509	pobj	DAG/PKC,in
R5334	T6511	T6490	conj	mediated,are
R5337	T6512	T6511	dobj	control,mediated
R5342	T6513	T6512	prep	of,control
R5346	T6514	T6513	pobj	NFκB,of
R5350	T6515	T6490	punct	.,are
R5353	T6486	T6490	advmod	Thus,are
R5354	T6487	T6490	punct	",",are
R5355	T6488	T6489	compound	PKD,kinases
R5356	T6489	T6490	nsubj	kinases,are
R5357	T6490	T6490	ROOT	are,are
R5358	T6491	T6492	advmod	neither,essential
R5359	T6492	T6490	acomp	essential,are
R5360	T6493	T6492	cc	nor,essential
R5361	T6494	T6492	conj	sufficient,essential
R5362	T6495	T6496	aux	to,mediate
R5363	T6496	T6494	xcomp	mediate,sufficient
R5364	T6497	T6499	amod	BCR-induced,activation
R5365	T6498	T6499	compound	NFκB,activation
R5366	T6499	T6496	dobj	activation,mediate
R5367	T6500	T6499	prep	in,activation
R5368	T6501	T6502	compound	DT40,B
R5369	T6502	T6503	compound	B,cells

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T6532	1937-1952	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6533	2057-2072	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6534	2493-2508	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6535	745-749	http://purl.obolibrary.org/obo/GO_0004707	denotes	MAPK
T6536	745-760	http://purl.obolibrary.org/obo/GO_0000165	denotes	MAPK signalling
T6537	886-894	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T6538	2076-2084	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T6516	32-42	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6517	198-208	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6518	553-563	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6519	750-760	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6520	1144-1154	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6521	1401-1411	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6522	1746-1756	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6523	2879-2889	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6524	3241-3248	http://purl.obolibrary.org/obo/GO_0023052	denotes	signals
T6525	32-51	http://purl.obolibrary.org/obo/GO_0007165	denotes	signalling pathways
T6526	750-769	http://purl.obolibrary.org/obo/GO_0007165	denotes	signalling pathways
T6527	553-572	http://purl.obolibrary.org/obo/GO_0007165	denotes	signalling cascades
T6528	716-739	http://purl.obolibrary.org/obo/GO_0006468	denotes	protein phosphorylation
T6529	724-739	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6530	858-873	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6531	1487-1502	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6539	2512-2520	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T6540	1116-1126	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T6541	1832-1842	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T6542	3561-3571	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T6543	1373-1379	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T6544	1732-1764	http://purl.obolibrary.org/obo/GO_0030522	denotes	intracellular signalling pathway
T6545	1732-1764	http://purl.obolibrary.org/obo/GO_0035556	denotes	intracellular signalling pathway
T6546	1732-1764	http://purl.obolibrary.org/obo/GO_1902532	denotes	intracellular signalling pathway
T6547	1732-1764	http://purl.obolibrary.org/obo/GO_1902531	denotes	intracellular signalling pathway
T6548	1732-1764	http://purl.obolibrary.org/obo/GO_1902533	denotes	intracellular signalling pathway
T6549	2935-2948	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6550	3092-3105	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6551	3137-3150	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6552	3629-3644	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T6553	3824-3839	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T6554	4184-4187	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T6581	706-723	http://purl.obolibrary.org/obo/GO_0003735	denotes	ribosomal protein
T6582	745-749	http://purl.obolibrary.org/obo/GO_0004707	denotes	MAPK
T6583	1902-1910	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibody
T6584	2121-2129	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibody
T6585	4184-4187	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T6555	71-76	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6556	249-254	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6557	377-382	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6558	412-417	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6559	492-497	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6560	612-617	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6561	810-815	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6562	1020-1025	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6563	1190-1195	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6564	1220-1225	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6565	1546-1551	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6566	1661-1666	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6567	1863-1868	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6568	2169-2174	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6569	2281-2286	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6570	3450-3455	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6571	3714-3719	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6572	3881-3886	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6573	4021-4026	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6574	4142-4147	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6575	930-943	http://purl.obolibrary.org/obo/GO_0005622	denotes	intracellular
T6576	1732-1745	http://purl.obolibrary.org/obo/GO_0005622	denotes	intracellular
T6577	1902-1910	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibody
T6578	2121-2129	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibody
T6579	1902-1910	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibody
T6580	2121-2129	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibody

sentences

Id	Subject	Object	Predicate	Lexical cue
T5008	77-255	Sentence	denotes	To further explore the contribution of PKD kinases to DT40 B cell biology we investigated whether specific BCR-regulated signalling events were defective in the PKD-null B cells.
T5009	256-447	Sentence	denotes	Initial experiments revealed that surface expression of the BCR was reduced in PKD1/3−/− (and in PKD1/3−/−:Flag-PKD3+ve) cells compared to wild-type DT40 B cells (Fig. 3A and data not shown).
T5010	448-628	Sentence	denotes	Nevertheless, BCR-crosslinking of PKD1/3−/− cells was sufficient to induce the activation of a number of signalling cascades, similar to that observed in wild-type cells (Fig. 3B).
T5011	629-826	Sentence	denotes	Hence, BCR-induced activation of the Akt, mTOR/p70 S6 kinase (as shown by S6 ribosomal protein phosphorylation) and MAPK signalling pathways was clearly detectable in PKD1/3-null B cells (Fig. 3B).
T5012	827-1043	Sentence	denotes	Furthermore, enhanced tyrosine phosphorylation of multiple cellular proteins as well as an increase in intracellular calcium levels was also observed following BCR stimulation of PKD1/3-null B cells (data not shown).
T5013	1044-1236	Sentence	denotes	We did observe that the strength of BCR (but not phorbol ester)-induced regulation of the Erk1-RSK1 signalling pathway was reduced in PKD1/3−/− B cells compared to wild-type B cells (Fig. 3B).
T5014	1237-1317	Sentence	denotes	One interpretation of this data is that PKD enzymes may modulate Erk activation.
T5015	1318-1461	Sentence	denotes	Indeed, PKD enzymes have previously been linked to the growth factor-regulated Erk signalling in fibroblast and endothelial cell lines [33–35].
T5016	1462-1765	Sentence	denotes	However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway.
T5017	1766-2004	Sentence	denotes	To search for other potential PKD targets that may show defective regulation in PKD1/3−/− DT40 B cells, we used a PKD substrate phospho-antibody that recognises consensus phosphorylation sequences targeted by PKD enzymes (LxRxxpS/T) [36].
T5018	2005-2219	Sentence	denotes	As shown in Fig. 3C, phorbol ester- and BCR-induced phosphorylation of cellular substrates detected by this phospho-antibody was similar in wild-type and PKD1/3−/− cells and is therefore independent of PKD enzymes.
T5019	2220-2434	Sentence	denotes	However, pretreatment of both wild-type and PKD1/3−/− DT40 B cells with GF109203X, a bisindoylmaleimide derivative that inhibits PKCs prevented the induction of proteins that contain phosphorylated LxRxxS/T motifs.
T5020	2435-2560	Sentence	denotes	Thus loss of PKD1/3 enzymes does not globally disrupt the phosphorylation of cellular proteins that contain LxRxxpS/T motifs.
T5021	2561-2698	Sentence	denotes	This result is perhaps not surprising as LxRxxS/T motifs also act as good substrates for other serine/threonine kinases such as MAPKAPK2.
T5022	2699-2866	Sentence	denotes	However these experiments do provide further evidence that phosphospecific antisera are not sufficiently selective to be designated kinase specific substrate antisera.
T5023	2867-3013	Sentence	denotes	BCR-induced signalling pathways culminate in the activation of gene transcription events that control B cell survival, proliferation and function.
T5024	3014-3158	Sentence	denotes	In this context, it has been proposed that PKD family members control of gene transcription through activation of the NFκB transcription factor.
T5025	3159-3347	Sentence	denotes	Thus, PKD-mediated activation of NFκB occurs downstream of a variety of different signals, including mROS/oxidative stress, lysophosphatidic acid and the Bcr-Abl oncogene [17,21,23,30,37].
T5026	3348-3444	Sentence	denotes	Furthermore, expression of an activated PKD1 mutant enhances HPK1-mediated NFκB activation [38].
T5027	3445-3594	Sentence	denotes	In B cells, NFκB is known to be regulated via DAG and PKCβ [39,40] but whether PKDs are key intermediaries for NFκB regulation has not been explored.
T5028	3595-3775	Sentence	denotes	The data (Fig. 4A) show that NFκB transcriptional activity was strongly induced in both wild-type and PKD1/3−/− DT40 B cells in response to either phorbol ester or BCR stimulation.
T5029	3776-4037	Sentence	denotes	In contrast, BCR and phorbol ester-induced NFκB transcriptional activity was abolished in PKCβ−/− DT40 B cells (Fig. 4A), although strong activation of PKD kinases (as assessed by autophosphorylation of PKD1 at S916) was observed in the PKCβ−/− cells (Fig. 4B).
T5030	4038-4213	Sentence	denotes	Thus, PKD kinases are neither essential nor sufficient to mediate BCR-induced NFκB activation in DT40 B cells and hence do not participate in DAG/PKC mediated control of NFκB.
T62	0-76	Sentence	denotes	3.3 Antigen receptor regulated signalling pathways in PKD-null DT40 B cells
T63	77-255	Sentence	denotes	To further explore the contribution of PKD kinases to DT40 B cell biology we investigated whether specific BCR-regulated signalling events were defective in the PKD-null B cells.
T64	256-447	Sentence	denotes	Initial experiments revealed that surface expression of the BCR was reduced in PKD1/3−/− (and in PKD1/3−/−:Flag-PKD3+ve) cells compared to wild-type DT40 B cells (Fig. 3A and data not shown).
T65	448-628	Sentence	denotes	Nevertheless, BCR-crosslinking of PKD1/3−/− cells was sufficient to induce the activation of a number of signalling cascades, similar to that observed in wild-type cells (Fig. 3B).
T66	629-826	Sentence	denotes	Hence, BCR-induced activation of the Akt, mTOR/p70 S6 kinase (as shown by S6 ribosomal protein phosphorylation) and MAPK signalling pathways was clearly detectable in PKD1/3-null B cells (Fig. 3B).
T67	827-1043	Sentence	denotes	Furthermore, enhanced tyrosine phosphorylation of multiple cellular proteins as well as an increase in intracellular calcium levels was also observed following BCR stimulation of PKD1/3-null B cells (data not shown).
T68	1044-1236	Sentence	denotes	We did observe that the strength of BCR (but not phorbol ester)-induced regulation of the Erk1-RSK1 signalling pathway was reduced in PKD1/3−/− B cells compared to wild-type B cells (Fig. 3B).
T69	1237-1317	Sentence	denotes	One interpretation of this data is that PKD enzymes may modulate Erk activation.
T70	1318-1461	Sentence	denotes	Indeed, PKD enzymes have previously been linked to the growth factor-regulated Erk signalling in fibroblast and endothelial cell lines [33–35].
T71	1462-1765	Sentence	denotes	However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway.
T72	1766-2004	Sentence	denotes	To search for other potential PKD targets that may show defective regulation in PKD1/3−/− DT40 B cells, we used a PKD substrate phospho-antibody that recognises consensus phosphorylation sequences targeted by PKD enzymes (LxRxxpS/T) [36].
T73	2005-2219	Sentence	denotes	As shown in Fig. 3C, phorbol ester- and BCR-induced phosphorylation of cellular substrates detected by this phospho-antibody was similar in wild-type and PKD1/3−/− cells and is therefore independent of PKD enzymes.
T74	2220-2434	Sentence	denotes	However, pretreatment of both wild-type and PKD1/3−/− DT40 B cells with GF109203X, a bisindoylmaleimide derivative that inhibits PKCs prevented the induction of proteins that contain phosphorylated LxRxxS/T motifs.
T75	2435-2560	Sentence	denotes	Thus loss of PKD1/3 enzymes does not globally disrupt the phosphorylation of cellular proteins that contain LxRxxpS/T motifs.
T76	2561-2698	Sentence	denotes	This result is perhaps not surprising as LxRxxS/T motifs also act as good substrates for other serine/threonine kinases such as MAPKAPK2.
T77	2699-2866	Sentence	denotes	However these experiments do provide further evidence that phosphospecific antisera are not sufficiently selective to be designated kinase specific substrate antisera.
T78	2867-3013	Sentence	denotes	BCR-induced signalling pathways culminate in the activation of gene transcription events that control B cell survival, proliferation and function.
T79	3014-3158	Sentence	denotes	In this context, it has been proposed that PKD family members control of gene transcription through activation of the NFκB transcription factor.
T80	3159-3347	Sentence	denotes	Thus, PKD-mediated activation of NFκB occurs downstream of a variety of different signals, including mROS/oxidative stress, lysophosphatidic acid and the Bcr-Abl oncogene [17,21,23,30,37].
T81	3348-3444	Sentence	denotes	Furthermore, expression of an activated PKD1 mutant enhances HPK1-mediated NFκB activation [38].
T82	3445-3594	Sentence	denotes	In B cells, NFκB is known to be regulated via DAG and PKCβ [39,40] but whether PKDs are key intermediaries for NFκB regulation has not been explored.
T83	3595-3775	Sentence	denotes	The data (Fig. 4A) show that NFκB transcriptional activity was strongly induced in both wild-type and PKD1/3−/− DT40 B cells in response to either phorbol ester or BCR stimulation.
T84	3776-4037	Sentence	denotes	In contrast, BCR and phorbol ester-induced NFκB transcriptional activity was abolished in PKCβ−/− DT40 B cells (Fig. 4A), although strong activation of PKD kinases (as assessed by autophosphorylation of PKD1 at S916) was observed in the PKCβ−/− cells (Fig. 4B).
T85	4038-4213	Sentence	denotes	Thus, PKD kinases are neither essential nor sufficient to mediate BCR-induced NFκB activation in DT40 B cells and hence do not participate in DAG/PKC mediated control of NFκB.

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation
T6905	335-339	Protein	denotes	PKD1
T6906	340-341	Protein	denotes	3
T6907	353-357	Protein	denotes	PKD1
T6908	358-359	Protein	denotes	3
T6909	368-372	Protein	denotes	PKD3
T6910	482-486	Protein	denotes	PKD1
T6911	487-488	Protein	denotes	3
T6912	640-647	Positive_regulation	denotes	induced
T6913	640-647	Positive_regulation	denotes	induced
T6914	640-647	Positive_regulation	denotes	induced
T6915	648-658	Positive_regulation	denotes	activation
T6916	648-658	Positive_regulation	denotes	activation
T6917	648-658	Positive_regulation	denotes	activation
T6918	666-669	Protein	denotes	Akt
T6919	671-675	Protein	denotes	mTOR
T6920	703-723	Protein	denotes	S6 ribosomal protein
T6921	724-739	Phosphorylation	denotes	phosphorylation
T6922	782-792	Negative_regulation	denotes	detectable	true
T6923	782-792	Negative_regulation	denotes	detectable	true
T6924	782-792	Negative_regulation	denotes	detectable	true
T6925	782-792	Negative_regulation	denotes	detectable	true
T6926	782-792	Negative_regulation	denotes	detectable	true
T6927	782-792	Negative_regulation	denotes	detectable	true
T6928	796-800	Protein	denotes	PKD1
T6929	801-802	Protein	denotes	3
T6930	803-807	Negative_regulation	denotes	null
T6931	803-807	Negative_regulation	denotes	null
T6932	1006-1010	Protein	denotes	PKD1
T6933	1011-1012	Protein	denotes	3
T6934	1134-1138	Protein	denotes	Erk1
T6935	1139-1143	Protein	denotes	RSK1
T6942	1627-1628	Protein	denotes	3
T6943	1637-1641	Protein	denotes	PKD1
T6936	1178-1182	Protein	denotes	PKD1
T6937	1183-1184	Protein	denotes	3
T6938	1523-1527	Protein	denotes	PKD1
T6939	1528-1529	Protein	denotes	3
T6940	1538-1542	Protein	denotes	PKD3
T6941	1622-1626	Protein	denotes	PKD1
T6944	1642-1643	Protein	denotes	3
T6945	1652-1656	Protein	denotes	PKD3
T6946	1846-1850	Protein	denotes	PKD1
T6947	1851-1852	Protein	denotes	3
T6948	2159-2163	Protein	denotes	PKD1
T6949	2164-2165	Protein	denotes	3
T6950	2264-2268	Protein	denotes	PKD1
T6951	2269-2270	Protein	denotes	3
T6952	2440-2444	Negative_regulation	denotes	loss
T6953	2440-2444	Negative_regulation	denotes	loss
T6954	2448-2452	Protein	denotes	PKD1
T6955	2453-2454	Protein	denotes	3
T6956	2689-2697	Protein	denotes	MAPKAPK2
T6957	3313-3329	Protein	denotes	Bcr-Abl oncogene
T6958	3361-3387	Positive_regulation	denotes	expression of an activated
T6959	3388-3392	Protein	denotes	PKD1
T6960	3409-3413	Protein	denotes	HPK1
T6961	3499-3503	Protein	denotes	PKCβ
T6962	3697-3701	Protein	denotes	PKD1
T6963	3702-3703	Protein	denotes	3
T6964	3866-3871	Protein	denotes	PKCβ−
T6965	3956-3975	Phosphorylation	denotes	autophosphorylation
T6966	3979-3983	Protein	denotes	PKD1
T6967	3987-3991	Entity	denotes	S916
T6968	3997-4005	Positive_regulation	denotes	observed
T6969	4013-4018	Protein	denotes	PKCβ−
R5508	T6931	T6926	causeOf	null,detectable
R5509	T6965	T6968	themeOf	autophosphorylation,observed
R5510	T6967	T6965	themeOf	S916,autophosphorylation
R5511	T6967	T6966	partOf	S916,PKD1
R5479	T6912	T6922	themeOf	induced,detectable
R5486	T6912	T6924	themeOf	induced,detectable
R5487	T6913	T6927	themeOf	induced,detectable
R5488	T6913	T6926	themeOf	induced,detectable
R5489	T6914	T6923	themeOf	induced,detectable
R5490	T6914	T6925	themeOf	induced,detectable
R5491	T6915	T6914	themeOf	activation,induced
R5492	T6916	T6912	themeOf	activation,induced
R5493	T6917	T6913	themeOf	activation,induced
R5494	T6918	T6917	themeOf	Akt,activation
R5495	T6919	T6916	themeOf	mTOR,activation
R5496	T6920	T6921	themeOf	S6 ribosomal protein,phosphorylation
R5497	T6921	T6915	themeOf	phosphorylation,activation
R5498	T6928	T6931	themeOf	PKD1,null
R5499	T6929	T6930	themeOf	3,null
R5500	T6930	T6927	causeOf	null,detectable
R5501	T6954	T6953	themeOf	PKD1,loss
R5502	T6930	T6924	causeOf	null,detectable
R5503	T6930	T6925	causeOf	null,detectable
R5504	T6955	T6952	themeOf	3,loss
R5505	T6931	T6922	causeOf	null,detectable
R5506	T6931	T6923	causeOf	null,detectable
R5507	T6959	T6958	themeOf	PKD1,expression of an activated

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation
T4955	666-669	Protein	denotes	Akt
T4956	671-675	Protein	denotes	mTOR
T4957	703-723	Protein	denotes	S6 ribosomal protein
T4958	724-739	Phosphorylation	denotes	phosphorylation
T4959	782-792	Negative_regulation	denotes	detectable	true
T4960	782-792	Negative_regulation	denotes	detectable	true
T4961	782-792	Negative_regulation	denotes	detectable	true
T4962	782-792	Negative_regulation	denotes	detectable	true
T4963	782-792	Negative_regulation	denotes	detectable	true
T4964	782-792	Negative_regulation	denotes	detectable	true
T4965	796-800	Protein	denotes	PKD1
T4966	801-802	Protein	denotes	3
T4967	803-807	Negative_regulation	denotes	null
T4968	803-807	Negative_regulation	denotes	null
T4969	1006-1010	Protein	denotes	PKD1
T4970	1011-1012	Protein	denotes	3
T4971	1134-1138	Protein	denotes	Erk1
T4972	1139-1143	Protein	denotes	RSK1
T4973	1178-1182	Protein	denotes	PKD1
T4974	1183-1184	Protein	denotes	3
T4975	1523-1527	Protein	denotes	PKD1
T4976	1528-1529	Protein	denotes	3
T4977	1538-1542	Protein	denotes	PKD3
T4978	1622-1626	Protein	denotes	PKD1
T4979	1627-1628	Protein	denotes	3
T4980	1637-1641	Protein	denotes	PKD1
T4981	1642-1643	Protein	denotes	3
T4982	1652-1656	Protein	denotes	PKD3
T4983	1846-1850	Protein	denotes	PKD1
T4984	1851-1852	Protein	denotes	3
T4985	2159-2163	Protein	denotes	PKD1
T4986	2164-2165	Protein	denotes	3
T4987	2264-2268	Protein	denotes	PKD1
T4988	2269-2270	Protein	denotes	3
T4989	2440-2444	Negative_regulation	denotes	loss
T4990	2440-2444	Negative_regulation	denotes	loss
T4991	2448-2452	Protein	denotes	PKD1
T4992	2453-2454	Protein	denotes	3
T4993	2689-2697	Protein	denotes	MAPKAPK2
T4994	3313-3329	Protein	denotes	Bcr-Abl oncogene
T4995	3361-3387	Positive_regulation	denotes	expression of an activated
T4996	3388-3392	Protein	denotes	PKD1
T4997	3409-3413	Protein	denotes	HPK1
T4998	3499-3503	Protein	denotes	PKCβ
T4999	3697-3701	Protein	denotes	PKD1
T5000	3702-3703	Protein	denotes	3
T5001	3866-3871	Protein	denotes	PKCβ−
T5002	3956-3975	Phosphorylation	denotes	autophosphorylation
T5003	3979-3983	Protein	denotes	PKD1
T5004	3987-3991	Entity	denotes	S916
T5005	3997-4005	Positive_regulation	denotes	observed
T5006	4013-4018	Protein	denotes	PKCβ−
T4942	335-339	Protein	denotes	PKD1
T4943	340-341	Protein	denotes	3
T4944	353-357	Protein	denotes	PKD1
T4945	358-359	Protein	denotes	3
T4946	368-372	Protein	denotes	PKD3
T4947	482-486	Protein	denotes	PKD1
T4948	487-488	Protein	denotes	3
T4949	640-647	Positive_regulation	denotes	induced
T4950	640-647	Positive_regulation	denotes	induced
T4951	640-647	Positive_regulation	denotes	induced
T4952	648-658	Positive_regulation	denotes	activation
T4953	648-658	Positive_regulation	denotes	activation
T4954	648-658	Positive_regulation	denotes	activation
R3904	T4949	T4959	themeOf	induced,detectable
R3905	T4949	T4961	themeOf	induced,detectable
R3906	T4950	T4964	themeOf	induced,detectable
R3907	T4950	T4963	themeOf	induced,detectable
R3908	T4951	T4960	themeOf	induced,detectable
R3909	T4951	T4962	themeOf	induced,detectable
R3910	T4952	T4951	themeOf	activation,induced
R3911	T4953	T4949	themeOf	activation,induced
R3912	T4954	T4950	themeOf	activation,induced
R3913	T4955	T4954	themeOf	Akt,activation
R3914	T4956	T4953	themeOf	mTOR,activation
R3915	T4957	T4958	themeOf	S6 ribosomal protein,phosphorylation
R3916	T4958	T4952	themeOf	phosphorylation,activation
R3917	T4965	T4968	themeOf	PKD1,null
R3918	T4966	T4967	themeOf	3,null
R3919	T4967	T4964	causeOf	null,detectable
R3920	T4967	T4961	causeOf	null,detectable
R3921	T4967	T4962	causeOf	null,detectable
R3922	T4968	T4959	causeOf	null,detectable
R3923	T4968	T4960	causeOf	null,detectable
R3924	T4968	T4963	causeOf	null,detectable
R3925	T4991	T4990	themeOf	PKD1,loss
R3926	T4992	T4989	themeOf	3,loss
R3927	T4996	T4995	themeOf	PKD1,expression of an activated
R3928	T5002	T5005	themeOf	autophosphorylation,observed
R3929	T5004	T5002	themeOf	S916,autophosphorylation
R3930	T5004	T5003	partOf	S916,PKD1

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T5705	184-187	P11274	denotes	BCR
T5706	316-319	P11274	denotes	BCR
T5707	335-339	P98161	denotes	PKD1
T5708	353-357	P98161	denotes	PKD1
T5709	368-372	Q99853	denotes	PKD3
T5710	462-465	P11274	denotes	BCR
T5711	482-486	P98161	denotes	PKD1
T5712	636-639	P11274	denotes	BCR
T5713	666-669	P31751	denotes	Akt
T5714	666-669	Q9Y243	denotes	Akt
T5715	666-669	P31749	denotes	Akt
T5716	671-675	P42345	denotes	mTOR
T5717	796-800	P98161	denotes	PKD1
T5718	987-990	P11274	denotes	BCR
T5719	1006-1010	P98161	denotes	PKD1
T5720	1080-1083	P11274	denotes	BCR
T5721	1134-1138	P27361	denotes	Erk1
T5722	1178-1182	P98161	denotes	PKD1
T5723	1471-1474	P11274	denotes	BCR
T5724	1523-1527	P98161	denotes	PKD1
T5725	1538-1542	Q99853	denotes	PKD3
T5726	1593-1596	P11274	denotes	BCR
T5727	1622-1626	P98161	denotes	PKD1
T5728	1637-1641	P98161	denotes	PKD1
T5729	1652-1656	Q99853	denotes	PKD3
T5730	1846-1850	P98161	denotes	PKD1
T5731	2045-2048	P11274	denotes	BCR
T5732	2159-2163	P98161	denotes	PKD1
T5733	2264-2268	P98161	denotes	PKD1
T5734	2448-2452	P98161	denotes	PKD1
T5735	2867-2870	P11274	denotes	BCR
T5736	3313-3316	P11274	denotes	Bcr
T5737	3317-3320	P00519	denotes	Abl
T5738	3388-3392	P98161	denotes	PKD1
T5739	3697-3701	P98161	denotes	PKD1
T5740	3759-3762	P11274	denotes	BCR
T5741	3789-3792	P11274	denotes	BCR
T5742	3979-3983	P98161	denotes	PKD1
T5743	4104-4107	P11274	denotes	BCR

test2

Id	Subject	Object	Predicate	Lexical cue	Negation
T4882	298-308	Gene_expression	denotes	expression
T4883	324-331	Negative_regulation	denotes	reduced
T4884	335-339	Protein	denotes	PKD1
T4885	340-341	Protein	denotes	3
T4886	353-357	Protein	denotes	PKD1
T4887	358-359	Protein	denotes	3
T4888	368-372	Protein	denotes	PKD3
T4889	482-486	Protein	denotes	PKD1	true
T4890	487-488	Protein	denotes	3
T4891	640-647	Positive_regulation	denotes	induced	true
T4892	648-658	Positive_regulation	denotes	activation
T4893	666-669	Protein	denotes	Akt	true
T4894	671-675	Protein	denotes	mTOR	true
T4895	703-723	Protein	denotes	S6 ribosomal protein	true
T4896	724-739	Phosphorylation	denotes	phosphorylation	true
T4897	796-800	Protein	denotes	PKD1
T4898	801-802	Protein	denotes	3
T4899	803-807	Negative_regulation	denotes	null
T4900	1006-1010	Protein	denotes	PKD1
T4901	1011-1012	Protein	denotes	3
T4902	1013-1017	Negative_regulation	denotes	null
T4903	1116-1126	Regulation	denotes	regulation
T4904	1134-1138	Protein	denotes	Erk1
T4905	1139-1143	Protein	denotes	RSK1
T4906	1167-1174	Negative_regulation	denotes	reduced
T4907	1178-1182	Protein	denotes	PKD1
T4908	1183-1184	Protein	denotes	3
T4909	1475-1482	Positive_regulation	denotes	induced
T4910	1487-1502	Phosphorylation	denotes	phosphorylation
T4911	1512-1519	Negative_regulation	denotes	reduced
T4912	1523-1527	Protein	denotes	PKD1
T4913	1528-1529	Protein	denotes	3
T4914	1538-1542	Protein	denotes	PKD3
T4915	1622-1626	Protein	denotes	PKD1
T4916	1627-1628	Protein	denotes	3
T4917	1637-1641	Protein	denotes	PKD1
T4918	1642-1643	Protein	denotes	3
T4919	1652-1656	Protein	denotes	PKD3
T4920	1846-1850	Protein	denotes	PKD1
T4921	1851-1852	Protein	denotes	3
T4922	2159-2163	Protein	denotes	PKD1
T4923	2164-2165	Protein	denotes	3
T4924	2264-2268	Protein	denotes	PKD1
T4925	2269-2270	Protein	denotes	3
T4926	2440-2444	Negative_regulation	denotes	loss
T4927	2448-2452	Protein	denotes	PKD1
T4928	2453-2454	Protein	denotes	3
T4929	2689-2697	Protein	denotes	MAPKAPK2
T4930	3313-3329	Protein	denotes	Bcr-Abl oncogene
T4931	3378-3387	Positive_regulation	denotes	activated
T4932	3388-3392	Protein	denotes	PKD1
T4933	3409-3413	Protein	denotes	HPK1
T4934	3477-3486	Regulation	denotes	regulated
T4935	3499-3503	Protein	denotes	PKCβ
T4936	3697-3701	Protein	denotes	PKD1
T4937	3702-3703	Protein	denotes	3
T4938	3866-3871	Protein	denotes	PKCβ−
T4939	3956-3975	Phosphorylation	denotes	autophosphorylation
T4940	3979-3983	Protein	denotes	PKD1
T4941	4013-4018	Protein	denotes	PKCβ−
R3888	T4882	T4883	themeOf	expression,reduced
R3889	T4892	T4891	themeOf	activation,induced
R3890	T4893	T4892	themeOf	Akt,activation
R3891	T4894	T4892	themeOf	mTOR,activation
R3892	T4895	T4896	themeOf	S6 ribosomal protein,phosphorylation
R3893	T4896	T4892	themeOf	phosphorylation,activation
R3894	T4897	T4899	themeOf	PKD1,null
R3895	T4898	T4899	themeOf	3,null
R3896	T4900	T4902	themeOf	PKD1,null
R3897	T4901	T4902	themeOf	3,null
R3898	T4909	T4911	themeOf	induced,reduced
R3899	T4910	T4909	themeOf	phosphorylation,induced
R3900	T4910	T4911	themeOf	phosphorylation,reduced
R3901	T4927	T4926	themeOf	PKD1,loss
R3902	T4935	T4934	causeOf	PKCβ,regulated
R3903	T4940	T4939	themeOf	PKD1,autophosphorylation

PMC:1942070 / 8937-13150 JSONTXT

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PMC:1942070 / 8937-13150 JSON TXT