PMC:1942070 / 4530-13151 JSON TXT

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2_test

Id	Subject	Object	Predicate	Lexical cue
17349631-16449666-30580535	292-293	16449666	denotes	1
17349631-16449666-30580536	988-989	16449666	denotes	1
17349631-15728188-30580537	1075-1077	15728188	denotes	24
17349631-16678913-30580538	2493-2495	16678913	denotes	20
17349631-12505989-30580539	3740-3742	12505989	denotes	32
17349631-16166634-30580539	3740-3742	16166634	denotes	32
17349631-16421204-30580539	3740-3742	16421204	denotes	32
17349631-15145937-30580539	3740-3742	15145937	denotes	32
17349631-16006559-30580540	5864-5866	16006559	denotes	35
17349631-14963034-30580540	5864-5866	14963034	denotes	35
17349631-8995387-30580541	6407-6409	8995387	denotes	36
17349631-12505989-30580542	7750-7752	12505989	denotes	37
17349631-15604256-30580542	7750-7752	15604256	denotes	37
17349631-16166634-30580542	7750-7752	16166634	denotes	37
17349631-15024053-30580542	7750-7752	15024053	denotes	37
17349631-15743830-30580543	7847-7849	15743830	denotes	38
17349631-16356855-30580544	7915-7917	16356855	denotes	40
17349631-16301747-30580544	7915-7917	16301747	denotes	40

MyTest

Id	Subject	Object	Predicate	Lexical cue
17349631-16449666-30580535	292-293	16449666	denotes	1
17349631-16449666-30580536	988-989	16449666	denotes	1
17349631-15728188-30580537	1075-1077	15728188	denotes	24
17349631-16678913-30580538	2493-2495	16678913	denotes	20
17349631-12505989-30580539	3740-3742	12505989	denotes	32
17349631-16166634-30580539	3740-3742	16166634	denotes	32
17349631-16421204-30580539	3740-3742	16421204	denotes	32
17349631-15145937-30580539	3740-3742	15145937	denotes	32
17349631-16006559-30580540	5864-5866	16006559	denotes	35
17349631-14963034-30580540	5864-5866	14963034	denotes	35
17349631-8995387-30580541	6407-6409	8995387	denotes	36
17349631-12505989-30580542	7750-7752	12505989	denotes	37
17349631-15604256-30580542	7750-7752	15604256	denotes	37
17349631-16166634-30580542	7750-7752	16166634	denotes	37
17349631-15024053-30580542	7750-7752	15024053	denotes	37
17349631-15743830-30580543	7847-7849	15743830	denotes	38
17349631-16356855-30580544	7915-7917	16356855	denotes	40
17349631-16301747-30580544	7915-7917	16301747	denotes	40

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T2289	22-24	IN	denotes	of
T2290	25-30	NN	denotes	HSP27
T2291	31-46	NN	denotes	phosphorylation
T2292	47-49	IN	denotes	in
T2293	50-54	NN	denotes	DT40
T2294	55-56	NN	denotes	B
T2295	57-62	NN	denotes	cells
T2296	63-70	VB	denotes	lacking
T2297	71-81	NN	denotes	expression
T2298	82-84	IN	denotes	of
T2299	85-88	NN	denotes	PKD
T2300	89-95	NN	denotes	family
T2301	96-103	NN	denotes	kinases
T2302	104-108	NN	denotes	DT40
T2303	109-110	NN	denotes	B
T2304	111-116	NN	denotes	cells
T2305	117-124	VB	denotes	express
T2306	125-128	CD	denotes	two
T2307	129-132	NN	denotes	PKD
T2308	133-141	NN	denotes	isoforms
T2309	141-142	-COMMA-	denotes	,
T2310	143-147	NN	denotes	PKD1
T2311	148-151	CC	denotes	and
T2312	152-156	NN	denotes	PKD3
T2313	156-157	-COMMA-	denotes	,
T2314	158-161	CC	denotes	and
T2315	162-164	IN	denotes	as
T2316	165-175	RB	denotes	previously
T2317	176-185	VB	denotes	described
T2318	186-188	PRP	denotes	we
T2319	189-193	VB	denotes	have
T2320	194-202	RB	denotes	recently
T2321	203-212	VB	denotes	generated
T2322	213-217	NN	denotes	DT40
T2323	218-219	NN	denotes	B
T2324	220-224	NN	denotes	cell
T2325	225-230	NN	denotes	lines
T2326	231-235	WDT	denotes	that
T2327	236-240	VB	denotes	lack
T2328	241-251	NN	denotes	expression
T2329	252-254	IN	denotes	of
T2330	255-261	CC	denotes	either
T2331	262-266	NN	denotes	PKD1
T2332	267-269	CC	denotes	or
T2333	270-274	NN	denotes	PKD3
T2334	275-277	CC	denotes	or
T2335	278-282	DT	denotes	both
T2336	283-290	NN	denotes	enzymes
T2337	291-292	-LRB-	denotes	[
T2338	292-293	CD	denotes	1
T2339	293-294	-RRB-	denotes	]
T2340	296-298	IN	denotes	In
T2341	299-309	VB	denotes	generating
T2342	310-313	DT	denotes	the
T2343	314-320	JJ	denotes	double
T2344	321-329	NN	denotes	knockout
T2345	330-334	NN	denotes	cell
T2346	335-340	NN	denotes	lines
T2347	341-343	PRP	denotes	we
T2348	344-352	VB	denotes	targeted
T2349	353-356	DT	denotes	the
T2350	357-361	NN	denotes	PKD1
T2351	362-366	NN	denotes	loci
T2352	367-369	IN	denotes	in
T2353	370-371	DT	denotes	a
T2354	372-379	NN	denotes	PKD3−/−
T2355	380-384	NN	denotes	cell
T2356	385-389	NN	denotes	line
T2357	390-394	WDT	denotes	that
T2358	395-404	VB	denotes	expressed
T2359	405-406	DT	denotes	a
T2360	407-416	NN	denotes	Flag-PKD3
T2361	417-426	NN	denotes	transgene
T2362	427-432	IN	denotes	under
T2363	433-436	DT	denotes	the
T2364	437-444	NN	denotes	control
T2365	445-447	IN	denotes	of
T2366	448-449	DT	denotes	a
T2367	450-471	JJ	denotes	doxycycline-inducible
T2368	472-480	NN	denotes	promoter
T2369	482-487	RB	denotes	Hence
T2370	487-488	-COMMA-	denotes	,
T2371	489-491	IN	denotes	in
T2372	492-495	DT	denotes	the
T2373	496-504	NN	denotes	presence
T2374	505-507	IN	denotes	of
T2375	508-519	NN	denotes	doxycycline
T2376	519-520	-COMMA-	denotes	,
T2377	521-530	NN	denotes	Flag-PKD3
T2378	531-541	NN	denotes	expression
T2379	542-544	IN	denotes	in
T2380	545-551	NN	denotes	PKD1/3
T2381	552-558	JJ	denotes	double
T2382	559-567	JJ	denotes	knockout
T2383	568-573	NN	denotes	cells
T2384	574-576	VB	denotes	is
T2385	577-587	JJ	denotes	comparable
T2386	588-590	TO	denotes	to
T2387	591-601	JJ	denotes	endogenous
T2388	602-606	NN	denotes	PKD3
T2389	607-614	JJ	denotes	present
T2390	615-617	IN	denotes	in
T2391	618-627	JJ	denotes	wild-type
T2392	628-632	NN	denotes	DT40
T2393	633-638	NN	denotes	cells
T2394	639-642	CC	denotes	and
T2395	643-650	NN	denotes	removal
T2396	651-653	IN	denotes	of
T2397	654-665	NN	denotes	doxycycline
T2398	666-670	IN	denotes	from
T2399	671-674	DT	denotes	the
T2400	675-682	NN	denotes	culture
T2401	683-688	NN	denotes	media
T2402	689-692	IN	denotes	for
T2403	693-694	CD	denotes	5
T2404	695-699	NN	denotes	days
T2405	700-707	VB	denotes	results
T2406	708-710	IN	denotes	in
T2407	711-712	DT	denotes	a
T2408	713-723	RB	denotes	completely
T2409	724-728	JJ	denotes	null
T2410	729-732	NN	denotes	PKD
T2411	733-742	NN	denotes	phenotype
T2412	743-744	-LRB-	denotes	(
T2413	744-748	NN	denotes	Fig.
T2414	749-751	NN	denotes	1A
T2415	751-752	-RRB-	denotes	)
T2416	754-764	RB	denotes	Previously
T2417	764-765	-COMMA-	denotes	,
T2418	766-768	PRP	denotes	we
T2419	769-773	VB	denotes	have
T2420	774-786	VB	denotes	demonstrated
T2421	787-791	IN	denotes	that
T2422	792-807	NN	denotes	phosphorylation
T2423	808-811	CC	denotes	and
T2424	812-819	JJ	denotes	nuclear
T2425	820-829	NN	denotes	exclusion
T2426	830-832	IN	denotes	of
T2427	833-838	NN	denotes	class
T2428	839-841	CD	denotes	II
T2429	842-849	NN	denotes	histone
T2430	850-862	NN	denotes	deacetylases
T2431	863-864	-LRB-	denotes	(
T2432	864-869	NN	denotes	HDACs
T2433	869-870	-RRB-	denotes	)
T2434	871-877	IN	denotes	during
T2435	878-881	NN	denotes	BCR
T2436	882-892	NN	denotes	engagement
T2437	893-895	VB	denotes	is
T2438	896-905	JJ	denotes	defective
T2439	906-908	IN	denotes	in
T2440	909-918	NN	denotes	PKD1/3−/−
T2441	919-920	NN	denotes	B
T2442	921-926	NN	denotes	cells
T2443	927-930	CC	denotes	and
T2444	931-934	MD	denotes	can
T2445	935-943	VB	denotes	restored
T2446	944-948	IN	denotes	upon
T2447	949-962	NN	denotes	re-expression
T2448	963-965	IN	denotes	of
T2449	966-967	DT	denotes	a
T2450	968-974	JJ	denotes	single
T2451	975-978	NN	denotes	PKD
T2452	979-986	NN	denotes	isoform
T2453	987-988	-LRB-	denotes	[
T2454	988-989	CD	denotes	1
T2455	989-990	-RRB-	denotes	]
T2456	992-995	DT	denotes	The
T2457	996-1001	JJ	denotes	small
T2458	1002-1006	NN	denotes	heat
T2459	1007-1012	NN	denotes	shock
T2460	1013-1020	NN	denotes	protein
T2461	1021-1026	NN	denotes	HSP27
T2462	1027-1030	VB	denotes	has
T2463	1031-1039	RB	denotes	recently
T2464	1040-1044	VB	denotes	been
T2465	1045-1053	VB	denotes	proposed
T2466	1054-1056	IN	denotes	as
T2467	1057-1058	DT	denotes	a
T2468	1059-1063	NN	denotes	PKD1
T2469	1064-1073	NN	denotes	substrate
T2470	1074-1075	-LRB-	denotes	[
T2471	1075-1077	CD	denotes	24
T2472	1077-1078	-RRB-	denotes	]
T2473	1079-1082	CC	denotes	and
T2474	1083-1085	PRP	denotes	we
T2475	1086-1097	RB	denotes	accordingly
T2476	1098-1106	VB	denotes	assessed
T2477	1107-1114	IN	denotes	whether
T2478	1115-1123	JJ	denotes	PKD-null
T2479	1124-1128	NN	denotes	DT40
T2480	1129-1134	NN	denotes	cells
T2481	1135-1139	VB	denotes	have
T2482	1140-1149	JJ	denotes	defective
T2483	1150-1165	NN	denotes	phosphorylation
T2484	1166-1168	IN	denotes	of
T2485	1169-1174	NN	denotes	HSP27
T2486	1175-1177	IN	denotes	on
T2487	1178-1184	NN	denotes	serine
T2488	1185-1187	CD	denotes	82
T2489	1187-1188	-COMMA-	denotes	,
T2490	1189-1192	DT	denotes	the
T2491	1193-1201	VB	denotes	proposed
T2492	1202-1206	NN	denotes	PKD1
T2493	1207-1216	NN	denotes	substrate
T2494	1217-1225	NN	denotes	sequence
T2495	1227-1229	PRP	denotes	We
T2496	1230-1239	RB	denotes	initially
T2497	1240-1252	VB	denotes	investigated
T2498	1253-1256	DT	denotes	the
T2499	1257-1267	NN	denotes	regulation
T2500	1268-1270	IN	denotes	of
T2501	1271-1276	NN	denotes	HSP27
T2502	1277-1292	NN	denotes	phosphorylation
T2503	1293-1295	IN	denotes	in
T2504	1296-1302	JJ	denotes	single
T2505	1303-1311	NN	denotes	knockout
T2506	1312-1316	NN	denotes	DT40
T2507	1317-1318	NN	denotes	B
T2508	1319-1324	NN	denotes	cells
T2509	1325-1332	VB	denotes	lacking
T2510	1333-1339	CC	denotes	either
T2511	1340-1344	NN	denotes	PKD1
T2512	1345-1347	CC	denotes	or
T2513	1348-1352	NN	denotes	PKD3
T2514	1354-1356	IN	denotes	As
T2515	1357-1362	VB	denotes	shown
T2516	1363-1365	IN	denotes	in
T2517	1366-1370	NNP	denotes	Fig.
T2518	1371-1373	NN	denotes	1B
T2519	1373-1374	-COMMA-	denotes	,
T2520	1375-1385	NN	denotes	activation
T2521	1386-1388	IN	denotes	of
T2522	1389-1392	DT	denotes	the
T2523	1393-1396	NN	denotes	BCR
T2524	1397-1399	CC	denotes	or
T2525	1400-1409	NN	denotes	treatment
T2526	1410-1414	IN	denotes	with
T2527	1415-1418	DT	denotes	the
T2528	1419-1430	JJ	denotes	DAG-mimetic
T2529	1431-1435	NN	denotes	PdBu
T2530	1436-1445	VB	denotes	increased
T2531	1446-1449	DT	denotes	the
T2532	1450-1456	NN	denotes	levels
T2533	1457-1459	IN	denotes	of
T2534	1460-1465	NN	denotes	HSP27
T2535	1466-1481	NN	denotes	phosphorylation
T2536	1482-1484	IN	denotes	at
T2537	1485-1488	NN	denotes	S82
T2538	1489-1491	IN	denotes	in
T2539	1492-1501	JJ	denotes	wild-type
T2540	1502-1506	NN	denotes	DT40
T2541	1507-1508	NN	denotes	B
T2542	1509-1514	NN	denotes	cells
T2543	1516-1519	NN	denotes	BCR
T2544	1520-1523	CC	denotes	and
T2545	1524-1531	NN	denotes	phorbol
T2546	1532-1537	NN	denotes	ester
T2547	1538-1545	NN	denotes	signals
T2548	1546-1550	VB	denotes	were
T2549	1551-1555	RB	denotes	also
T2550	1556-1560	JJ	denotes	able
T2551	1561-1563	TO	denotes	to
T2552	1564-1572	VB	denotes	increase
T2553	1573-1578	NN	denotes	HSP27
T2554	1579-1594	NN	denotes	phosphorylation
T2555	1595-1597	IN	denotes	in
T2556	1598-1602	NN	denotes	PKD1
T2557	1603-1605	CC	denotes	or
T2558	1606-1610	NN	denotes	PKD3
T2559	1611-1617	JJ	denotes	single
T2560	1618-1626	NN	denotes	knockout
T2561	1627-1631	NN	denotes	DT40
T2562	1632-1633	NN	denotes	B
T2563	1634-1639	NN	denotes	cells
T2564	1640-1641	-LRB-	denotes	(
T2565	1641-1645	NN	denotes	Fig.
T2566	1646-1648	NN	denotes	1B
T2567	1648-1649	-RRB-	denotes	)
T2568	1651-1658	RB	denotes	However
T2569	1658-1659	-COMMA-	denotes	,
T2570	1660-1664	NN	denotes	BCR-
T2571	1665-1668	CC	denotes	and
T2572	1669-1676	NN	denotes	phorbol
T2573	1677-1690	JJ	denotes	ester-induced
T2574	1691-1706	NN	denotes	phosphorylation
T2575	1707-1709	IN	denotes	of
T2576	1710-1715	NN	denotes	HSP27
T2577	1716-1718	IN	denotes	on
T2578	1719-1722	NN	denotes	S82
T2579	1723-1726	VB	denotes	was
T2580	1727-1736	VB	denotes	abolished
T2581	1737-1739	IN	denotes	in
T2582	1740-1741	NN	denotes	B
T2583	1742-1747	NN	denotes	cells
T2584	1748-1752	WDT	denotes	that
T2585	1753-1759	VB	denotes	lacked
T2586	1760-1764	CC	denotes	both
T2587	1765-1769	NN	denotes	PKD1
T2588	1770-1773	CC	denotes	and
T2589	1774-1778	NN	denotes	PKD3
T2590	1779-1780	-LRB-	denotes	(
T2591	1780-1784	NN	denotes	Fig.
T2592	1785-1787	NN	denotes	1C
T2593	1787-1788	-RRB-	denotes	)
T2594	1790-1803	RB	denotes	Significantly
T2595	1803-1804	-COMMA-	denotes	,
T2596	1805-1824	JJ	denotes	doxycycline-induced
T2597	1825-1835	NN	denotes	expression
T2598	1836-1838	IN	denotes	of
T2599	1839-1842	DT	denotes	the
T2600	1843-1852	NN	denotes	Flag-PKD3
T2601	1853-1862	NN	denotes	transgene
T2602	1863-1865	IN	denotes	in
T2603	1866-1869	DT	denotes	the
T2604	1870-1876	JJ	denotes	double
T2605	1877-1885	NN	denotes	knockout
T2606	1886-1891	NN	denotes	cells
T2607	1892-1895	VB	denotes	was
T2608	1896-1906	JJ	denotes	sufficient
T2609	1907-1909	TO	denotes	to
T2610	1910-1917	VB	denotes	restore
T2611	1918-1924	JJ	denotes	normal
T2612	1925-1935	NN	denotes	regulation
T2613	1936-1938	IN	denotes	of
T2614	1939-1944	NN	denotes	HSP27
T2615	1945-1960	NN	denotes	phosphorylation
T2616	1961-1962	-LRB-	denotes	(
T2617	1962-1966	NN	denotes	Fig.
T2618	1967-1969	NN	denotes	1C
T2619	1969-1970	-RRB-	denotes	)
T2620	1972-1974	IN	denotes	In
T2621	1975-1983	NN	denotes	contrast
T2622	1983-1984	-COMMA-	denotes	,
T2623	1985-1995	NN	denotes	expression
T2624	1996-1998	IN	denotes	of
T2625	1999-2000	DT	denotes	a
T2626	2001-2017	JJ	denotes	kinase-deficient
T2627	2018-2022	NN	denotes	PKD3
T2628	2023-2029	JJ	denotes	mutant
T2629	2030-2037	NN	denotes	protein
T2630	2038-2040	IN	denotes	in
T2631	2041-2044	DT	denotes	the
T2632	2045-2051	JJ	denotes	double
T2633	2052-2060	NN	denotes	knockout
T2634	2061-2066	NN	denotes	cells
T2635	2067-2070	VB	denotes	was
T2636	2071-2074	RB	denotes	not
T2637	2075-2079	JJ	denotes	able
T2638	2080-2082	TO	denotes	to
T2639	2083-2090	VB	denotes	restore
T2640	2091-2095	NN	denotes	BCR-
T2641	2096-2098	CC	denotes	or
T2642	2099-2106	NN	denotes	phorbol
T2643	2107-2120	JJ	denotes	ester-induced
T2644	2121-2126	NN	denotes	HSP27
T2645	2127-2142	NN	denotes	phosphorylation
T2646	2143-2144	-LRB-	denotes	(
T2647	2144-2148	NN	denotes	Fig.
T2648	2149-2151	NN	denotes	1D
T2649	2151-2152	-RRB-	denotes	)
T2650	2154-2159	RB	denotes	Hence
T2651	2159-2160	-COMMA-	denotes	,
T2652	2161-2165	NN	denotes	PKD3
T2653	2166-2168	RB	denotes	as
T2654	2169-2173	RB	denotes	well
T2655	2174-2176	IN	denotes	as
T2656	2177-2181	NN	denotes	PKD1
T2657	2182-2185	MD	denotes	can
T2658	2186-2194	VB	denotes	regulate
T2659	2195-2200	NN	denotes	HSP27
T2660	2201-2216	NN	denotes	phosphorylation
T2661	2217-2220	CC	denotes	and
T2662	2221-2223	IN	denotes	in
T2663	2224-2228	NN	denotes	DT40
T2664	2229-2230	NN	denotes	B
T2665	2231-2236	NN	denotes	cells
T2666	2237-2241	PRP	denotes	they
T2667	2242-2245	VB	denotes	are
T2668	2246-2258	RB	denotes	functionally
T2669	2259-2268	JJ	denotes	redundant
T2670	2269-2271	IN	denotes	as
T2671	2272-2277	NN	denotes	HSP27
T2672	2278-2285	NN	denotes	kinases
T3837	2302-2315	NN	denotes	proliferation
T3838	2316-2319	CC	denotes	and
T3839	2320-2328	NN	denotes	survival
T3840	2329-2331	IN	denotes	in
T3841	2332-2336	NN	denotes	DT40
T3842	2337-2338	NN	denotes	B
T3843	2339-2344	NN	denotes	cells
T3844	2345-2352	VB	denotes	lacking
T3845	2353-2363	NN	denotes	expression
T3846	2364-2366	IN	denotes	of
T3847	2367-2370	NN	denotes	PKD
T3848	2371-2377	NN	denotes	family
T3849	2378-2385	NN	denotes	kinases
T3850	2386-2389	NN	denotes	PKD
T3851	2390-2397	NN	denotes	enzymes
T3852	2398-2402	VB	denotes	have
T3853	2403-2413	RB	denotes	previously
T3854	2414-2418	VB	denotes	been
T3855	2419-2425	VB	denotes	linked
T3856	2426-2428	TO	denotes	to
T3857	2429-2432	DT	denotes	the
T3858	2433-2443	NN	denotes	regulation
T3859	2444-2446	IN	denotes	of
T3860	2447-2451	NN	denotes	cell
T3861	2452-2465	NN	denotes	proliferation
T3862	2466-2469	CC	denotes	and
T3863	2470-2478	NN	denotes	survival
T3864	2479-2480	-LRB-	denotes	(
T3865	2480-2488	VB	denotes	reviewed
T3866	2489-2491	IN	denotes	in
T3867	2492-2493	-LRB-	denotes	[
T3868	2493-2495	CD	denotes	20
T3869	2495-2496	-RRB-	denotes	]
T3870	2496-2497	-RRB-	denotes	)
T3871	2499-2501	TO	denotes	To
T3872	2502-2513	VB	denotes	investigate
T3873	2514-2517	DT	denotes	the
T3874	2518-2524	NN	denotes	effect
T3875	2525-2529	IN	denotes	that
T3876	2530-2534	NN	denotes	loss
T3877	2535-2537	IN	denotes	of
T3878	2538-2541	NN	denotes	PKD
T3879	2542-2549	NN	denotes	kinases
T3880	2550-2553	VB	denotes	had
T3881	2554-2556	IN	denotes	on
T3882	2557-2558	NN	denotes	B
T3883	2559-2563	NN	denotes	cell
T3884	2564-2572	NN	denotes	survival
T3885	2573-2579	CC	denotes	and/or
T3886	2580-2593	NN	denotes	proliferation
T3887	2594-2596	PRP	denotes	we
T3888	2597-2605	VB	denotes	cultured
T3889	2606-2615	JJ	denotes	wild-type
T3890	2616-2619	CC	denotes	and
T3891	2620-2628	JJ	denotes	PKD-null
T3892	2629-2634	NN	denotes	cells
T3893	2635-2637	IN	denotes	in
T3894	2638-2641	DT	denotes	the
T3895	2642-2650	NN	denotes	presence
T3896	2651-2652	-LRB-	denotes	(
T3897	2652-2661	NN	denotes	PKD1/3−/−
T3898	2661-2662	-COLON-	denotes	:
T3899	2663-2675	NN	denotes	Flag-PKD3+ve
T3900	2675-2676	-RRB-	denotes	)
T3901	2677-2679	CC	denotes	or
T3902	2680-2687	NN	denotes	absence
T3903	2688-2689	-LRB-	denotes	(
T3904	2689-2698	NN	denotes	PKD1/3−/−
T3905	2698-2699	-RRB-	denotes	)
T3906	2700-2702	IN	denotes	of
T3907	2703-2714	NN	denotes	doxycycline
T3908	2715-2718	CC	denotes	and
T3909	2719-2728	VB	denotes	monitored
T3910	2729-2740	JJ	denotes	exponential
T3911	2741-2747	NN	denotes	growth
T3912	2749-2751	IN	denotes	As
T3913	2752-2757	VB	denotes	shown
T3914	2758-2760	IN	denotes	in
T3915	2761-2765	NNP	denotes	Fig.
T3916	2766-2768	NN	denotes	2A
T3917	2768-2769	-COMMA-	denotes	,
T3918	2770-2779	NN	denotes	PKD1/3−/−
T3919	2780-2785	NN	denotes	cells
T3920	2786-2798	VB	denotes	proliferated
T3921	2799-2812	RB	denotes	exponentially
T3922	2813-2816	CC	denotes	and
T3923	2817-2830	NN	denotes	re-expression
T3924	2831-2833	IN	denotes	of
T3925	2834-2843	NN	denotes	Flag-PKD3
T3926	2844-2846	IN	denotes	in
T3927	2847-2852	DT	denotes	these
T3928	2853-2858	NN	denotes	cells
T3929	2859-2862	VB	denotes	had
T3930	2863-2865	DT	denotes	no
T3931	2866-2872	NN	denotes	impact
T3932	2873-2875	IN	denotes	on
T3933	2876-2879	DT	denotes	the
T3934	2880-2884	NN	denotes	rate
T3935	2885-2887	IN	denotes	of
T3936	2888-2901	NN	denotes	proliferation
T3937	2903-2914	RB	denotes	Furthermore
T3938	2914-2915	-COMMA-	denotes	,
T3939	2916-2919	DT	denotes	the
T3940	2920-2929	NN	denotes	viability
T3941	2930-2932	IN	denotes	of
T3942	2933-2942	NN	denotes	PKD1/3−/−
T3943	2943-2944	NN	denotes	B
T3944	2945-2950	NN	denotes	cells
T3945	2951-2957	IN	denotes	during
T3946	2958-2965	JJ	denotes	routine
T3947	2966-2975	NN	denotes	culturing
T3948	2976-2979	VB	denotes	was
T3949	2980-2983	RB	denotes	not
T3950	2984-2997	RB	denotes	significantly
T3951	2998-3007	JJ	denotes	different
T3952	3008-3012	IN	denotes	from
T3953	3013-3017	DT	denotes	that
T3954	3018-3020	IN	denotes	of
T3955	3021-3030	JJ	denotes	wild-type
T3956	3031-3032	NN	denotes	B
T3957	3033-3038	NN	denotes	cells
T3958	3039-3040	-LRB-	denotes	(
T3959	3040-3044	NN	denotes	data
T3960	3045-3048	RB	denotes	not
T3961	3049-3054	VB	denotes	shown
T3962	3054-3055	-RRB-	denotes	)
T3963	3057-3059	PRP	denotes	It
T3964	3060-3063	VB	denotes	was
T3965	3064-3069	VB	denotes	noted
T3966	3070-3074	IN	denotes	that
T3967	3075-3078	DT	denotes	the
T3968	3079-3089	NN	denotes	population
T3969	3090-3098	NN	denotes	doubling
T3970	3099-3103	NN	denotes	time
T3971	3104-3106	IN	denotes	of
T3972	3107-3116	NN	denotes	PKD1/3−/−
T3973	3117-3122	NN	denotes	cells
T3974	3123-3126	VB	denotes	was
T3975	3127-3135	RB	denotes	slightly
T3976	3136-3142	JJ	denotes	slower
T3977	3143-3147	IN	denotes	than
T3978	3148-3152	DT	denotes	that
T3979	3153-3155	IN	denotes	of
T3980	3156-3160	JJ	denotes	wild
T3981	3161-3165	NN	denotes	type
T3982	3166-3170	NN	denotes	DT40
T3983	3171-3176	NN	denotes	cells
T3984	3177-3178	-LRB-	denotes	(
T3985	3178-3190	CD	denotes	12.7 ± 2.8 h
T3986	3191-3197	IN	denotes	versus
T3987	3198-3210	CD	denotes	10.2 ± 0.4 h
T3988	3210-3211	-RRB-	denotes	)
T3989	3212-3215	CC	denotes	but
T3990	3216-3219	DT	denotes	the
T3991	3220-3227	NN	denotes	failure
T3992	3228-3230	IN	denotes	of
T3993	3231-3235	NN	denotes	PKD3
T3994	3236-3249	NN	denotes	re-expression
T3995	3250-3252	TO	denotes	to
T3996	3253-3259	VB	denotes	modify
T3997	3260-3263	DT	denotes	the
T3998	3264-3277	NN	denotes	proliferation
T3999	3278-3282	NN	denotes	rate
T4000	3283-3285	IN	denotes	of
T4001	3286-3295	NN	denotes	PKD1/3−/−
T4002	3296-3301	NN	denotes	cells
T4003	3302-3310	VB	denotes	suggests
T4004	3311-3315	IN	denotes	that
T4005	3316-3321	DT	denotes	these
T4006	3322-3327	JJ	denotes	small
T4007	3328-3339	NN	denotes	differences
T4008	3340-3344	VB	denotes	were
T4009	3345-3349	RB	denotes	most
T4010	3350-3356	RB	denotes	likely
T4011	3357-3360	DT	denotes	the
T4012	3361-3367	NN	denotes	result
T4013	3368-3370	IN	denotes	of
T4014	3371-3377	JJ	denotes	clonal
T4015	3378-3387	NN	denotes	variation
T4016	3388-3391	CC	denotes	and
T4017	3392-3396	VB	denotes	were
T4018	3397-3400	RB	denotes	not
T4019	3401-3407	VB	denotes	caused
T4020	3408-3420	RB	denotes	specifically
T4021	3421-3423	IN	denotes	by
T4022	3424-3428	NN	denotes	loss
T4023	3429-3431	IN	denotes	of
T4024	3432-3435	NN	denotes	PKD
T4025	3436-3443	NN	denotes	enzymes
T4026	3445-3449	RB	denotes	Thus
T4027	3449-3450	-COMMA-	denotes	,
T4028	3451-3454	NN	denotes	PKD
T4029	3455-3461	NN	denotes	family
T4030	3462-3469	NN	denotes	enzymes
T4031	3470-3473	VB	denotes	are
T4032	3474-3477	RB	denotes	not
T4033	3478-3487	JJ	denotes	essential
T4034	3488-3491	IN	denotes	for
T4035	3492-3502	VB	denotes	regulating
T4036	3503-3508	JJ	denotes	basal
T4037	3509-3517	NN	denotes	survival
T4038	3518-3521	CC	denotes	and
T4039	3522-3535	NN	denotes	proliferation
T4040	3536-3538	IN	denotes	of
T4041	3539-3543	NN	denotes	DT40
T4042	3544-3545	NN	denotes	B
T4043	3546-3551	NN	denotes	cells
T4044	3553-3556	NN	denotes	PKD
T4045	3557-3564	NN	denotes	enzymes
T4046	3564-3565	-COMMA-	denotes	,
T4047	3566-3578	RB	denotes	specifically
T4048	3579-3583	NN	denotes	PKD1
T4049	3584-3587	CC	denotes	and
T4050	3588-3592	NN	denotes	PKD2
T4051	3592-3593	-COMMA-	denotes	,
T4052	3594-3598	VB	denotes	have
T4053	3599-3609	RB	denotes	previously
T4054	3610-3614	VB	denotes	been
T4055	3615-3621	VB	denotes	linked
T4056	3622-3624	TO	denotes	to
T4057	3625-3626	DT	denotes	a
T4058	3627-3637	JJ	denotes	protective
T4059	3638-3642	NN	denotes	role
T4060	3643-3650	IN	denotes	against
T4061	3651-3660	JJ	denotes	oxidative
T4062	3661-3675	JJ	denotes	stress-induced
T4063	3676-3682	NN	denotes	injury
T4064	3683-3685	IN	denotes	in
T4065	3686-3689	NN	denotes	3T3
T4066	3690-3700	NN	denotes	fibroblast
T4067	3700-3701	-COMMA-	denotes	,
T4068	3702-3706	NN	denotes	HeLa
T4069	3707-3710	CC	denotes	and
T4070	3711-3721	JJ	denotes	epithelial
T4071	3722-3726	NN	denotes	cell
T4072	3727-3732	NN	denotes	lines
T4073	3733-3734	-LRB-	denotes	[
T4074	3734-3742	CD	denotes	17,30–32
T4075	3742-3743	-RRB-	denotes	]
T4076	3745-3747	PRP	denotes	We
T4077	3748-3757	RB	denotes	therefore
T4078	3758-3767	VB	denotes	addressed
T4079	3768-3771	DT	denotes	the
T4080	3772-3776	NN	denotes	role
T4081	3777-3779	IN	denotes	of
T4082	3780-3783	NN	denotes	PKD
T4083	3784-3790	NN	denotes	family
T4084	3791-3798	NN	denotes	kinases
T4085	3799-3801	IN	denotes	in
T4086	3802-3812	VB	denotes	regulating
T4087	3813-3814	NN	denotes	B
T4088	3815-3819	NN	denotes	cell
T4089	3820-3828	NN	denotes	survival
T4090	3829-3831	IN	denotes	in
T4091	3832-3840	NN	denotes	response
T4092	3841-3843	TO	denotes	to
T4093	3844-3853	JJ	denotes	oxidative
T4094	3854-3860	NN	denotes	stress
T4095	3861-3864	CC	denotes	and
T4096	3865-3870	JJ	denotes	other
T4097	3871-3877	NN	denotes	stress
T4098	3878-3885	NN	denotes	stimuli
T4099	3887-3889	IN	denotes	As
T4100	3890-3895	VB	denotes	shown
T4101	3896-3898	IN	denotes	in
T4102	3899-3903	NNP	denotes	Fig.
T4103	3904-3906	NN	denotes	2B
T4104	3906-3907	-COMMA-	denotes	,
T4105	3908-3912	NN	denotes	loss
T4106	3913-3915	IN	denotes	of
T4107	3916-3922	NN	denotes	PKD1/3
T4108	3923-3933	NN	denotes	expression
T4109	3934-3937	VB	denotes	had
T4110	3938-3940	DT	denotes	no
T4111	3941-3952	JJ	denotes	significant
T4112	3953-3959	NN	denotes	impact
T4113	3960-3962	IN	denotes	on
T4114	3963-3966	DT	denotes	the
T4115	3967-3975	NN	denotes	survival
T4116	3976-3978	IN	denotes	of
T4117	3979-3983	NN	denotes	DT40
T4118	3984-3985	NN	denotes	B
T4119	3986-3991	NN	denotes	cells
T4120	3992-3994	IN	denotes	in
T4121	3995-4003	NN	denotes	response
T4122	4004-4006	TO	denotes	to
T4123	4007-4020	JJ	denotes	mitochondrial
T4124	4021-4027	NN	denotes	stress
T4125	4028-4035	NN	denotes	stimuli
T4126	4036-4037	-LRB-	denotes	(
T4127	4037-4041	NN	denotes	H2O2
T4128	4042-4044	CC	denotes	or
T4129	4045-4050	NN	denotes	serum
T4130	4051-4062	NN	denotes	deprivation
T4131	4062-4063	-RRB-	denotes	)
T4132	4063-4064	-COLON-	denotes	;
T4133	4065-4068	NN	denotes	DNA
T4134	4069-4077	NN	denotes	damaging
T4135	4078-4084	NN	denotes	agents
T4136	4085-4086	-LRB-	denotes	(
T4137	4086-4095	NN	denotes	etoposide
T4138	4096-4098	CC	denotes	or
T4139	4099-4110	NN	denotes	doxorubicin
T4140	4110-4111	-RRB-	denotes	)
T4141	4111-4112	-COLON-	denotes	;
T4142	4113-4115	NN	denotes	ER
T4143	4116-4123	NN	denotes	pathway
T4144	4124-4130	NN	denotes	stress
T4145	4131-4134	IN	denotes	due
T4146	4135-4137	TO	denotes	to
T4147	4138-4145	NN	denotes	calcium
T4148	4146-4154	NN	denotes	overload
T4149	4155-4156	-LRB-	denotes	(
T4150	4156-4168	NN	denotes	thapsigargin
T4151	4168-4169	-RRB-	denotes	)
T4152	4170-4172	CC	denotes	or
T4153	4173-4182	VB	denotes	following
T4154	4183-4192	VB	denotes	prolonged
T4155	4193-4202	NN	denotes	treatment
T4156	4203-4207	IN	denotes	with
T4157	4208-4215	NN	denotes	phorbol
T4158	4216-4222	NN	denotes	esters
T4159	4223-4225	CC	denotes	or
T4160	4226-4238	NN	denotes	Trichostatin
T4161	4239-4240	NN	denotes	A
T4162	4240-4241	-COMMA-	denotes	,
T4163	4242-4244	DT	denotes	an
T4164	4245-4254	NN	denotes	inhibitor
T4165	4255-4257	IN	denotes	of
T4166	4258-4263	NN	denotes	class
T4167	4264-4268	NN	denotes	I/II
T4168	4269-4274	NN	denotes	HDACs
T4169	4276-4280	RB	denotes	Thus
T4170	4280-4281	-COMMA-	denotes	,
T4171	4282-4285	NN	denotes	PKD
T4172	4286-4293	NN	denotes	kinases
T4173	4294-4296	VB	denotes	do
T4174	4297-4300	RB	denotes	not
T4175	4301-4305	VB	denotes	play
T4176	4306-4308	DT	denotes	an
T4177	4309-4318	JJ	denotes	essential
T4178	4319-4323	NN	denotes	role
T4179	4324-4326	IN	denotes	in
T4180	4327-4337	VB	denotes	regulating
T4181	4338-4339	NN	denotes	B
T4182	4340-4344	NN	denotes	cell
T4183	4345-4353	NN	denotes	survival
T4184	4354-4356	IN	denotes	in
T4185	4357-4365	NN	denotes	response
T4186	4366-4368	TO	denotes	to
T4187	4369-4370	DT	denotes	a
T4188	4371-4376	NN	denotes	range
T4189	4377-4379	IN	denotes	of
T4190	4380-4389	JJ	denotes	different
T4191	4390-4396	NN	denotes	stress
T4192	4397-4404	NN	denotes	stimuli
T5032	4420-4428	NN	denotes	receptor
T5033	4429-4438	VB	denotes	regulated
T5034	4439-4449	NN	denotes	signalling
T5035	4450-4458	NN	denotes	pathways
T5036	4459-4461	IN	denotes	in
T5037	4462-4470	JJ	denotes	PKD-null
T5038	4471-4475	NN	denotes	DT40
T5039	4476-4477	NN	denotes	B
T5040	4478-4483	NN	denotes	cells
T5041	4484-4486	TO	denotes	To
T5042	4487-4494	RB	denotes	further
T5043	4495-4502	VB	denotes	explore
T5044	4503-4506	DT	denotes	the
T5045	4507-4519	NN	denotes	contribution
T5046	4520-4522	IN	denotes	of
T5047	4523-4526	NN	denotes	PKD
T5048	4527-4534	NN	denotes	kinases
T5049	4535-4537	TO	denotes	to
T5050	4538-4542	NN	denotes	DT40
T5051	4543-4544	NN	denotes	B
T5052	4545-4549	NN	denotes	cell
T5053	4550-4557	NN	denotes	biology
T5054	4558-4560	PRP	denotes	we
T5055	4561-4573	VB	denotes	investigated
T5056	4574-4581	IN	denotes	whether
T5057	4582-4590	JJ	denotes	specific
T5058	4591-4604	JJ	denotes	BCR-regulated
T5059	4605-4615	NN	denotes	signalling
T5060	4616-4622	NN	denotes	events
T5061	4623-4627	VB	denotes	were
T5062	4628-4637	JJ	denotes	defective
T5063	4638-4640	IN	denotes	in
T5064	4641-4644	DT	denotes	the
T5065	4645-4653	JJ	denotes	PKD-null
T5066	4654-4655	NN	denotes	B
T5067	4656-4661	NN	denotes	cells
T5068	4663-4670	JJ	denotes	Initial
T5069	4671-4682	NN	denotes	experiments
T5070	4683-4691	VB	denotes	revealed
T5071	4692-4696	IN	denotes	that
T5072	4697-4704	NN	denotes	surface
T5073	4705-4715	NN	denotes	expression
T5074	4716-4718	IN	denotes	of
T5075	4719-4722	DT	denotes	the
T5076	4723-4726	NN	denotes	BCR
T5077	4727-4730	VB	denotes	was
T5078	4731-4738	VB	denotes	reduced
T5079	4739-4741	IN	denotes	in
T5080	4742-4751	NN	denotes	PKD1/3−/−
T5081	4752-4753	-LRB-	denotes	(
T5082	4753-4756	CC	denotes	and
T5083	4757-4759	IN	denotes	in
T5084	4760-4769	NN	denotes	PKD1/3−/−
T5085	4769-4770	-COLON-	denotes	:
T5086	4770-4782	NN	denotes	Flag-PKD3+ve
T5087	4782-4783	-RRB-	denotes	)
T5088	4784-4789	NN	denotes	cells
T5089	4790-4798	VB	denotes	compared
T5090	4799-4801	TO	denotes	to
T5091	4802-4811	JJ	denotes	wild-type
T5092	4812-4816	NN	denotes	DT40
T5093	4817-4818	NN	denotes	B
T5094	4819-4824	NN	denotes	cells
T5095	4825-4826	-LRB-	denotes	(
T5096	4826-4830	NN	denotes	Fig.
T5097	4831-4833	NN	denotes	3A
T5098	4834-4837	CC	denotes	and
T5099	4838-4842	NN	denotes	data
T5100	4843-4846	RB	denotes	not
T5101	4847-4852	VB	denotes	shown
T5102	4852-4853	-RRB-	denotes	)
T5103	4855-4867	RB	denotes	Nevertheless
T5104	4867-4868	-COMMA-	denotes	,
T5105	4869-4885	NN	denotes	BCR-crosslinking
T5106	4886-4888	IN	denotes	of
T5107	4889-4898	NN	denotes	PKD1/3−/−
T5108	4899-4904	NN	denotes	cells
T5109	4905-4908	VB	denotes	was
T5110	4909-4919	JJ	denotes	sufficient
T5111	4920-4922	TO	denotes	to
T5112	4923-4929	VB	denotes	induce
T5113	4930-4933	DT	denotes	the
T5114	4934-4944	NN	denotes	activation
T5115	4945-4947	IN	denotes	of
T5116	4948-4949	DT	denotes	a
T5117	4950-4956	NN	denotes	number
T5118	4957-4959	IN	denotes	of
T5119	4960-4970	NN	denotes	signalling
T5120	4971-4979	NN	denotes	cascades
T5121	4979-4980	-COMMA-	denotes	,
T5122	4981-4988	JJ	denotes	similar
T5123	4989-4991	TO	denotes	to
T5124	4992-4996	DT	denotes	that
T5125	4997-5005	VB	denotes	observed
T5126	5006-5008	IN	denotes	in
T5127	5009-5018	JJ	denotes	wild-type
T5128	5019-5024	NN	denotes	cells
T5129	5025-5026	-LRB-	denotes	(
T5130	5026-5030	NN	denotes	Fig.
T5131	5031-5033	NN	denotes	3B
T5132	5033-5034	-RRB-	denotes	)
T5133	5036-5041	RB	denotes	Hence
T5134	5041-5042	-COMMA-	denotes	,
T5135	5043-5054	JJ	denotes	BCR-induced
T5136	5055-5065	NN	denotes	activation
T5137	5066-5068	IN	denotes	of
T5138	5069-5072	DT	denotes	the
T5139	5073-5076	NN	denotes	Akt
T5140	5076-5077	-COMMA-	denotes	,
T5141	5078-5086	NN	denotes	mTOR/p70
T5142	5087-5089	NN	denotes	S6
T5143	5090-5096	NN	denotes	kinase
T5144	5097-5098	-LRB-	denotes	(
T5145	5098-5100	IN	denotes	as
T5146	5101-5106	VB	denotes	shown
T5147	5107-5109	IN	denotes	by
T5148	5110-5112	NN	denotes	S6
T5149	5113-5122	JJ	denotes	ribosomal
T5150	5123-5130	NN	denotes	protein
T5151	5131-5146	NN	denotes	phosphorylation
T5152	5146-5147	-RRB-	denotes	)
T5153	5148-5151	CC	denotes	and
T5154	5152-5156	NN	denotes	MAPK
T5155	5157-5167	NN	denotes	signalling
T5156	5168-5176	NN	denotes	pathways
T5157	5177-5180	VB	denotes	was
T5158	5181-5188	RB	denotes	clearly
T5159	5189-5199	JJ	denotes	detectable
T5160	5200-5202	IN	denotes	in
T5161	5203-5214	JJ	denotes	PKD1/3-null
T5162	5215-5216	NN	denotes	B
T5163	5217-5222	NN	denotes	cells
T5164	5223-5224	-LRB-	denotes	(
T5165	5224-5228	NN	denotes	Fig.
T5166	5229-5231	NN	denotes	3B
T5167	5231-5232	-RRB-	denotes	)
T5168	5234-5245	RB	denotes	Furthermore
T5169	5245-5246	-COMMA-	denotes	,
T5170	5247-5255	VB	denotes	enhanced
T5171	5256-5264	NN	denotes	tyrosine
T5172	5265-5280	NN	denotes	phosphorylation
T5173	5281-5283	IN	denotes	of
T5174	5284-5292	JJ	denotes	multiple
T5175	5293-5301	JJ	denotes	cellular
T5176	5302-5310	NN	denotes	proteins
T5177	5311-5313	RB	denotes	as
T5178	5314-5318	RB	denotes	well
T5179	5319-5321	IN	denotes	as
T5180	5322-5324	DT	denotes	an
T5181	5325-5333	NN	denotes	increase
T5182	5334-5336	IN	denotes	in
T5183	5337-5350	JJ	denotes	intracellular
T5184	5351-5358	NN	denotes	calcium
T5185	5359-5365	NN	denotes	levels
T5186	5366-5369	VB	denotes	was
T5187	5370-5374	RB	denotes	also
T5188	5375-5383	VB	denotes	observed
T5189	5384-5393	VB	denotes	following
T5190	5394-5397	NN	denotes	BCR
T5191	5398-5409	NN	denotes	stimulation
T5192	5410-5412	IN	denotes	of
T5193	5413-5424	JJ	denotes	PKD1/3-null
T5194	5425-5426	NN	denotes	B
T5195	5427-5432	NN	denotes	cells
T5196	5433-5434	-LRB-	denotes	(
T5197	5434-5438	NN	denotes	data
T5198	5439-5442	RB	denotes	not
T5199	5443-5448	VB	denotes	shown
T5200	5448-5449	-RRB-	denotes	)
T5201	5451-5453	PRP	denotes	We
T5202	5454-5457	VB	denotes	did
T5203	5458-5465	VB	denotes	observe
T5204	5466-5470	IN	denotes	that
T5205	5471-5474	DT	denotes	the
T5206	5475-5483	NN	denotes	strength
T5207	5484-5486	IN	denotes	of
T5208	5487-5490	NN	denotes	BCR
T5209	5491-5492	-LRB-	denotes	(
T5210	5492-5495	CC	denotes	but
T5211	5496-5499	RB	denotes	not
T5212	5500-5507	NN	denotes	phorbol
T5213	5508-5513	NN	denotes	ester
T5214	5513-5514	-RRB-	denotes	)
T5215	5514-5522	JJ	denotes	-induced
T5216	5523-5533	NN	denotes	regulation
T5217	5534-5536	IN	denotes	of
T5218	5537-5540	DT	denotes	the
T5219	5541-5550	NN	denotes	Erk1-RSK1
T5220	5551-5561	NN	denotes	signalling
T5221	5562-5569	NN	denotes	pathway
T5222	5570-5573	VB	denotes	was
T5223	5574-5581	VB	denotes	reduced
T5224	5582-5584	IN	denotes	in
T5225	5585-5594	NN	denotes	PKD1/3−/−
T5226	5595-5596	NN	denotes	B
T5227	5597-5602	NN	denotes	cells
T5228	5603-5611	VB	denotes	compared
T5229	5612-5614	TO	denotes	to
T5230	5615-5624	JJ	denotes	wild-type
T5231	5625-5626	NN	denotes	B
T5232	5627-5632	NN	denotes	cells
T5233	5633-5634	-LRB-	denotes	(
T5234	5634-5638	NN	denotes	Fig.
T5235	5639-5641	NN	denotes	3B
T5236	5641-5642	-RRB-	denotes	)
T5237	5644-5647	CD	denotes	One
T5238	5648-5662	NN	denotes	interpretation
T5239	5663-5665	IN	denotes	of
T5240	5666-5670	DT	denotes	this
T5241	5671-5675	NN	denotes	data
T5242	5676-5678	VB	denotes	is
T5243	5679-5683	IN	denotes	that
T5244	5684-5687	NN	denotes	PKD
T5245	5688-5695	NN	denotes	enzymes
T5246	5696-5699	MD	denotes	may
T5247	5700-5708	VB	denotes	modulate
T5248	5709-5712	NN	denotes	Erk
T5249	5713-5723	NN	denotes	activation
T5250	5725-5731	RB	denotes	Indeed
T5251	5731-5732	-COMMA-	denotes	,
T5252	5733-5736	NN	denotes	PKD
T5253	5737-5744	NN	denotes	enzymes
T5254	5745-5749	VB	denotes	have
T5255	5750-5760	RB	denotes	previously
T5256	5761-5765	VB	denotes	been
T5257	5766-5772	VB	denotes	linked
T5258	5773-5775	TO	denotes	to
T5259	5776-5779	DT	denotes	the
T5260	5780-5786	NN	denotes	growth
T5261	5787-5803	JJ	denotes	factor-regulated
T5262	5804-5807	NN	denotes	Erk
T5263	5808-5818	NN	denotes	signalling
T5264	5819-5821	IN	denotes	in
T5265	5822-5832	NN	denotes	fibroblast
T5266	5833-5836	CC	denotes	and
T5267	5837-5848	JJ	denotes	endothelial
T5268	5849-5853	NN	denotes	cell
T5269	5854-5859	NN	denotes	lines
T5270	5860-5861	-LRB-	denotes	[
T5271	5861-5866	CD	denotes	33–35
T5272	5866-5867	-RRB-	denotes	]
T5273	5869-5876	RB	denotes	However
T5274	5876-5877	-COMMA-	denotes	,
T5275	5878-5889	JJ	denotes	BCR-induced
T5276	5890-5893	NN	denotes	Erk
T5277	5894-5909	NN	denotes	phosphorylation
T5278	5910-5913	VB	denotes	was
T5279	5914-5918	RB	denotes	also
T5280	5919-5926	VB	denotes	reduced
T5281	5927-5929	IN	denotes	in
T5282	5930-5950	JJ	denotes	PKD1/3−/−-Flag-PKD3+
T5283	5951-5952	NN	denotes	B
T5284	5953-5958	NN	denotes	cells
T5285	5959-5960	-LRB-	denotes	(
T5286	5960-5964	NN	denotes	data
T5287	5965-5968	RB	denotes	not
T5288	5969-5974	VB	denotes	shown
T5289	5974-5975	-RRB-	denotes	)
T5290	5976-5986	VB	denotes	suggesting
T5291	5987-5991	IN	denotes	that
T5292	5992-5999	VB	denotes	reduced
T5293	6000-6003	NN	denotes	BCR
T5294	6004-6010	NN	denotes	levels
T5295	6011-6013	IN	denotes	on
T5296	6014-6017	DT	denotes	the
T5297	6018-6025	NN	denotes	surface
T5298	6026-6028	IN	denotes	of
T5299	6029-6038	NN	denotes	PKD1/3−/−
T5300	6039-6040	-LRB-	denotes	(
T5301	6040-6043	CC	denotes	and
T5302	6044-6064	JJ	denotes	PKD1/3−/−-Flag-PKD3+
T5303	6064-6065	-RRB-	denotes	)
T5304	6066-6067	NN	denotes	B
T5305	6068-6073	NN	denotes	cells
T5306	6074-6077	MD	denotes	may
T5307	6078-6084	PRP	denotes	itself
T5308	6085-6091	VB	denotes	impact
T5309	6092-6094	IN	denotes	on
T5310	6095-6098	DT	denotes	the
T5311	6099-6107	NN	denotes	strength
T5312	6108-6110	IN	denotes	of
T5313	6111-6121	NN	denotes	activation
T5314	6122-6124	IN	denotes	of
T5315	6125-6129	DT	denotes	this
T5316	6130-6138	JJ	denotes	specific
T5317	6139-6152	JJ	denotes	intracellular
T5318	6153-6163	NN	denotes	signalling
T5319	6164-6171	NN	denotes	pathway
T5320	6173-6175	TO	denotes	To
T5321	6176-6182	VB	denotes	search
T5322	6183-6186	IN	denotes	for
T5323	6187-6192	JJ	denotes	other
T5324	6193-6202	JJ	denotes	potential
T5325	6203-6206	NN	denotes	PKD
T5326	6207-6214	NN	denotes	targets
T5327	6215-6219	WDT	denotes	that
T5328	6220-6223	MD	denotes	may
T5329	6224-6228	VB	denotes	show
T5330	6229-6238	JJ	denotes	defective
T5331	6239-6249	NN	denotes	regulation
T5332	6250-6252	IN	denotes	in
T5333	6253-6262	NN	denotes	PKD1/3−/−
T5334	6263-6267	NN	denotes	DT40
T5335	6268-6269	NN	denotes	B
T5336	6270-6275	NN	denotes	cells
T5337	6275-6276	-COMMA-	denotes	,
T5338	6277-6279	PRP	denotes	we
T5339	6280-6284	VB	denotes	used
T5340	6285-6286	DT	denotes	a
T5341	6287-6290	NN	denotes	PKD
T5342	6291-6300	NN	denotes	substrate
T5343	6301-6317	NN	denotes	phospho-antibody
T5344	6318-6322	WDT	denotes	that
T5345	6323-6333	VB	denotes	recognises
T5346	6334-6343	NN	denotes	consensus
T5347	6344-6359	NN	denotes	phosphorylation
T5348	6360-6369	NN	denotes	sequences
T5349	6370-6378	VB	denotes	targeted
T5350	6379-6381	IN	denotes	by
T5351	6382-6385	NN	denotes	PKD
T5352	6386-6393	NN	denotes	enzymes
T5353	6394-6395	-LRB-	denotes	(
T5354	6395-6404	NN	denotes	LxRxxpS/T
T5355	6404-6405	-RRB-	denotes	)
T5356	6406-6407	-LRB-	denotes	[
T5357	6407-6409	CD	denotes	36
T5358	6409-6410	-RRB-	denotes	]
T5359	6412-6414	IN	denotes	As
T5360	6415-6420	VB	denotes	shown
T5361	6421-6423	IN	denotes	in
T5362	6424-6428	NNP	denotes	Fig.
T5363	6429-6431	NNP	denotes	3C
T5364	6431-6432	-COMMA-	denotes	,
T5365	6433-6440	NN	denotes	phorbol
T5366	6441-6447	NN	denotes	ester-
T5367	6448-6451	CC	denotes	and
T5368	6452-6463	JJ	denotes	BCR-induced
T5369	6464-6479	NN	denotes	phosphorylation
T5370	6480-6482	IN	denotes	of
T5371	6483-6491	JJ	denotes	cellular
T5372	6492-6502	NN	denotes	substrates
T5373	6503-6511	VB	denotes	detected
T5374	6512-6514	IN	denotes	by
T5375	6515-6519	DT	denotes	this
T5376	6520-6536	NN	denotes	phospho-antibody
T5377	6537-6540	VB	denotes	was
T5378	6541-6548	JJ	denotes	similar
T5379	6549-6551	IN	denotes	in
T5380	6552-6561	JJ	denotes	wild-type
T5381	6562-6565	CC	denotes	and
T5382	6566-6575	NN	denotes	PKD1/3−/−
T5383	6576-6581	NN	denotes	cells
T5384	6582-6585	CC	denotes	and
T5385	6586-6588	VB	denotes	is
T5386	6589-6598	RB	denotes	therefore
T5387	6599-6610	JJ	denotes	independent
T5388	6611-6613	IN	denotes	of
T5389	6614-6617	NN	denotes	PKD
T5390	6618-6625	NN	denotes	enzymes
T5391	6627-6634	RB	denotes	However
T5392	6634-6635	-COMMA-	denotes	,
T5393	6636-6648	NN	denotes	pretreatment
T5394	6649-6651	IN	denotes	of
T5395	6652-6656	CC	denotes	both
T5396	6657-6666	JJ	denotes	wild-type
T5397	6667-6670	CC	denotes	and
T5398	6671-6680	NN	denotes	PKD1/3−/−
T5399	6681-6685	NN	denotes	DT40
T5400	6686-6687	NN	denotes	B
T5401	6688-6693	NN	denotes	cells
T5402	6694-6698	IN	denotes	with
T5403	6699-6708	NN	denotes	GF109203X
T5404	6708-6709	-COMMA-	denotes	,
T5405	6710-6711	DT	denotes	a
T5406	6712-6730	NN	denotes	bisindoylmaleimide
T5407	6731-6741	NN	denotes	derivative
T5408	6742-6746	WDT	denotes	that
T5409	6747-6755	VB	denotes	inhibits
T5410	6756-6760	NN	denotes	PKCs
T5411	6761-6770	VB	denotes	prevented
T5412	6771-6774	DT	denotes	the
T5413	6775-6784	NN	denotes	induction
T5414	6785-6787	IN	denotes	of
T5415	6788-6796	NN	denotes	proteins
T5416	6797-6801	WDT	denotes	that
T5417	6802-6809	VB	denotes	contain
T5418	6810-6824	VB	denotes	phosphorylated
T5419	6825-6833	NN	denotes	LxRxxS/T
T5420	6834-6840	NN	denotes	motifs
T5421	6842-6846	RB	denotes	Thus
T5422	6847-6851	NN	denotes	loss
T5423	6852-6854	IN	denotes	of
T5424	6855-6861	NN	denotes	PKD1/3
T5425	6862-6869	NN	denotes	enzymes
T5426	6870-6874	VB	denotes	does
T5427	6875-6878	RB	denotes	not
T5428	6879-6887	RB	denotes	globally
T5429	6888-6895	VB	denotes	disrupt
T5430	6896-6899	DT	denotes	the
T5431	6900-6915	NN	denotes	phosphorylation
T5432	6916-6918	IN	denotes	of
T5433	6919-6927	JJ	denotes	cellular
T5434	6928-6936	NN	denotes	proteins
T5435	6937-6941	WDT	denotes	that
T5436	6942-6949	VB	denotes	contain
T5437	6950-6959	NN	denotes	LxRxxpS/T
T5438	6960-6966	NN	denotes	motifs
T5439	6968-6972	DT	denotes	This
T5440	6973-6979	NN	denotes	result
T5441	6980-6982	VB	denotes	is
T5442	6983-6990	RB	denotes	perhaps
T5443	6991-6994	RB	denotes	not
T5444	6995-7005	JJ	denotes	surprising
T5445	7006-7008	IN	denotes	as
T5446	7009-7017	NN	denotes	LxRxxS/T
T5447	7018-7024	NN	denotes	motifs
T5448	7025-7029	RB	denotes	also
T5449	7030-7033	VB	denotes	act
T5450	7034-7036	IN	denotes	as
T5451	7037-7041	JJ	denotes	good
T5452	7042-7052	NN	denotes	substrates
T5453	7053-7056	IN	denotes	for
T5454	7057-7062	JJ	denotes	other
T5455	7063-7079	NN	denotes	serine/threonine
T5456	7080-7087	NN	denotes	kinases
T5457	7088-7092	JJ	denotes	such
T5458	7093-7095	IN	denotes	as
T5459	7096-7104	NN	denotes	MAPKAPK2
T5460	7106-7113	RB	denotes	However
T5461	7114-7119	DT	denotes	these
T5462	7120-7131	NN	denotes	experiments
T5463	7132-7134	VB	denotes	do
T5464	7135-7142	VB	denotes	provide
T5465	7143-7150	JJ	denotes	further
T5466	7151-7159	NN	denotes	evidence
T5467	7160-7164	IN	denotes	that
T5468	7165-7180	JJ	denotes	phosphospecific
T5469	7181-7189	NN	denotes	antisera
T5470	7190-7193	VB	denotes	are
T5471	7194-7197	RB	denotes	not
T5472	7198-7210	RB	denotes	sufficiently
T5473	7211-7220	JJ	denotes	selective
T5474	7221-7223	TO	denotes	to
T5475	7224-7226	VB	denotes	be
T5476	7227-7237	VB	denotes	designated
T5477	7238-7244	NN	denotes	kinase
T5478	7245-7253	JJ	denotes	specific
T5479	7254-7263	NN	denotes	substrate
T5480	7264-7272	NN	denotes	antisera
T5481	7274-7285	JJ	denotes	BCR-induced
T5482	7286-7296	NN	denotes	signalling
T5483	7297-7305	NN	denotes	pathways
T5484	7306-7315	VB	denotes	culminate
T5485	7316-7318	IN	denotes	in
T5486	7319-7322	DT	denotes	the
T5487	7323-7333	NN	denotes	activation
T5488	7334-7336	IN	denotes	of
T5489	7337-7341	NN	denotes	gene
T5490	7342-7355	NN	denotes	transcription
T5491	7356-7362	NN	denotes	events
T5492	7363-7367	WDT	denotes	that
T5493	7368-7375	VB	denotes	control
T5494	7376-7377	NN	denotes	B
T5495	7378-7382	NN	denotes	cell
T5496	7383-7391	NN	denotes	survival
T5497	7391-7392	-COMMA-	denotes	,
T5498	7393-7406	NN	denotes	proliferation
T5499	7407-7410	CC	denotes	and
T5500	7411-7419	NN	denotes	function
T5501	7421-7423	IN	denotes	In
T5502	7424-7428	DT	denotes	this
T5503	7429-7436	NN	denotes	context
T5504	7436-7437	-COMMA-	denotes	,
T5505	7438-7440	PRP	denotes	it
T5506	7441-7444	VB	denotes	has
T5507	7445-7449	VB	denotes	been
T5508	7450-7458	VB	denotes	proposed
T5509	7459-7463	IN	denotes	that
T5510	7464-7467	NN	denotes	PKD
T5511	7468-7474	NN	denotes	family
T5512	7475-7482	NN	denotes	members
T5513	7483-7490	NN	denotes	control
T5514	7491-7493	IN	denotes	of
T5515	7494-7498	NN	denotes	gene
T5516	7499-7512	NN	denotes	transcription
T5517	7513-7520	IN	denotes	through
T5518	7521-7531	NN	denotes	activation
T5519	7532-7534	IN	denotes	of
T5520	7535-7538	DT	denotes	the
T5521	7539-7543	NN	denotes	NFκB
T5522	7544-7557	NN	denotes	transcription
T5523	7558-7564	NN	denotes	factor
T5524	7566-7570	RB	denotes	Thus
T5525	7570-7571	-COMMA-	denotes	,
T5526	7572-7584	JJ	denotes	PKD-mediated
T5527	7585-7595	NN	denotes	activation
T5528	7596-7598	IN	denotes	of
T5529	7599-7603	NN	denotes	NFκB
T5530	7604-7610	VB	denotes	occurs
T5531	7611-7621	RB	denotes	downstream
T5532	7622-7624	IN	denotes	of
T5533	7625-7626	DT	denotes	a
T5534	7627-7634	NN	denotes	variety
T5535	7635-7637	IN	denotes	of
T5536	7638-7647	JJ	denotes	different
T5537	7648-7655	NN	denotes	signals
T5538	7655-7656	-COMMA-	denotes	,
T5539	7657-7666	VB	denotes	including
T5540	7667-7681	JJ	denotes	mROS/oxidative
T5541	7682-7688	NN	denotes	stress
T5542	7688-7689	-COMMA-	denotes	,
T5543	7690-7706	JJ	denotes	lysophosphatidic
T5544	7707-7711	NN	denotes	acid
T5545	7712-7715	CC	denotes	and
T5546	7716-7719	DT	denotes	the
T5547	7720-7727	NN	denotes	Bcr-Abl
T5548	7728-7736	NN	denotes	oncogene
T5549	7737-7738	-LRB-	denotes	[
T5550	7738-7752	CD	denotes	17,21,23,30,37
T5551	7752-7753	-RRB-	denotes	]
T5552	7755-7766	RB	denotes	Furthermore
T5553	7766-7767	-COMMA-	denotes	,
T5554	7768-7778	NN	denotes	expression
T5555	7779-7781	IN	denotes	of
T5556	7782-7784	DT	denotes	an
T5557	7785-7794	VB	denotes	activated
T5558	7795-7799	NN	denotes	PKD1
T5559	7800-7806	NN	denotes	mutant
T5560	7807-7815	VB	denotes	enhances
T5561	7816-7829	JJ	denotes	HPK1-mediated
T5562	7830-7834	NN	denotes	NFκB
T5563	7835-7845	NN	denotes	activation
T5564	7846-7847	-LRB-	denotes	[
T5565	7847-7849	CD	denotes	38
T5566	7849-7850	-RRB-	denotes	]
T5567	7852-7854	IN	denotes	In
T5568	7855-7856	NN	denotes	B
T5569	7857-7862	NN	denotes	cells
T5570	7862-7863	-COMMA-	denotes	,
T5571	7864-7868	NN	denotes	NFκB
T5572	7869-7871	VB	denotes	is
T5573	7872-7877	VB	denotes	known
T5574	7878-7880	TO	denotes	to
T5575	7881-7883	VB	denotes	be
T5576	7884-7893	VB	denotes	regulated
T5577	7894-7897	IN	denotes	via
T5578	7898-7901	NN	denotes	DAG
T5579	7902-7905	CC	denotes	and
T5580	7906-7910	NN	denotes	PKCβ
T5581	7911-7912	-LRB-	denotes	[
T5582	7912-7917	CD	denotes	39,40
T5583	7917-7918	-RRB-	denotes	]
T5584	7919-7922	CC	denotes	but
T5585	7923-7930	IN	denotes	whether
T5586	7931-7935	NN	denotes	PKDs
T5587	7936-7939	VB	denotes	are
T5588	7940-7943	JJ	denotes	key
T5589	7944-7958	NN	denotes	intermediaries
T5590	7959-7962	IN	denotes	for
T5591	7963-7967	NN	denotes	NFκB
T5592	7968-7978	NN	denotes	regulation
T5593	7979-7982	VB	denotes	has
T5594	7983-7986	RB	denotes	not
T5595	7987-7991	VB	denotes	been
T5596	7992-8000	VB	denotes	explored
T5597	8002-8005	DT	denotes	The
T5598	8006-8010	NN	denotes	data
T5599	8011-8012	-LRB-	denotes	(
T5600	8012-8016	NNP	denotes	Fig.
T5601	8017-8019	NN	denotes	4A
T5602	8019-8020	-RRB-	denotes	)
T5603	8021-8025	VB	denotes	show
T5604	8026-8030	IN	denotes	that
T5605	8031-8035	NN	denotes	NFκB
T5606	8036-8051	JJ	denotes	transcriptional
T5607	8052-8060	NN	denotes	activity
T5608	8061-8064	VB	denotes	was
T5609	8065-8073	RB	denotes	strongly
T5610	8074-8081	VB	denotes	induced
T5611	8082-8084	IN	denotes	in
T5612	8085-8089	CC	denotes	both
T5613	8090-8099	JJ	denotes	wild-type
T5614	8100-8103	CC	denotes	and
T5615	8104-8113	NN	denotes	PKD1/3−/−
T5616	8114-8118	NN	denotes	DT40
T5617	8119-8120	NN	denotes	B
T5618	8121-8126	NN	denotes	cells
T5619	8127-8129	IN	denotes	in
T5620	8130-8138	NN	denotes	response
T5621	8139-8141	TO	denotes	to
T5622	8142-8148	CC	denotes	either
T5623	8149-8156	NN	denotes	phorbol
T5624	8157-8162	NN	denotes	ester
T5625	8163-8165	CC	denotes	or
T5626	8166-8169	NN	denotes	BCR
T5627	8170-8181	NN	denotes	stimulation
T5628	8183-8185	IN	denotes	In
T5629	8186-8194	NN	denotes	contrast
T5630	8194-8195	-COMMA-	denotes	,
T5631	8196-8199	NN	denotes	BCR
T5632	8200-8203	CC	denotes	and
T5633	8204-8211	NN	denotes	phorbol
T5634	8212-8225	JJ	denotes	ester-induced
T5635	8226-8230	NN	denotes	NFκB
T5636	8231-8246	JJ	denotes	transcriptional
T5637	8247-8255	NN	denotes	activity
T5638	8256-8259	VB	denotes	was
T5639	8260-8269	VB	denotes	abolished
T5640	8270-8272	IN	denotes	in
T5641	8273-8280	NN	denotes	PKCβ−/−
T5642	8281-8285	NN	denotes	DT40
T5643	8286-8287	NN	denotes	B
T5644	8288-8293	NN	denotes	cells
T5645	8294-8295	-LRB-	denotes	(
T5646	8295-8299	NN	denotes	Fig.
T5647	8300-8302	NN	denotes	4A
T5648	8302-8303	-RRB-	denotes	)
T5649	8303-8304	-COMMA-	denotes	,
T5650	8305-8313	IN	denotes	although
T5651	8314-8320	JJ	denotes	strong
T5652	8321-8331	NN	denotes	activation
T5653	8332-8334	IN	denotes	of
T5654	8335-8338	NN	denotes	PKD
T5655	8339-8346	NN	denotes	kinases
T5656	8347-8348	-LRB-	denotes	(
T5657	8348-8350	IN	denotes	as
T5658	8351-8359	VB	denotes	assessed
T5659	8360-8362	IN	denotes	by
T5660	8363-8382	NN	denotes	autophosphorylation
T5661	8383-8385	IN	denotes	of
T5662	8386-8390	NN	denotes	PKD1
T5663	8391-8393	IN	denotes	at
T5664	8394-8398	NN	denotes	S916
T5665	8398-8399	-RRB-	denotes	)
T5666	8400-8403	VB	denotes	was
T5667	8404-8412	VB	denotes	observed
T5668	8413-8415	IN	denotes	in
T5669	8416-8419	DT	denotes	the
T5670	8420-8427	NN	denotes	PKCβ−/−
T5671	8428-8433	NN	denotes	cells
T5672	8434-8435	-LRB-	denotes	(
T5673	8435-8439	NN	denotes	Fig.
T5674	8440-8442	NN	denotes	4B
T5675	8442-8443	-RRB-	denotes	)
T5676	8445-8449	RB	denotes	Thus
T5677	8449-8450	-COMMA-	denotes	,
T5678	8451-8454	NN	denotes	PKD
T5679	8455-8462	NN	denotes	kinases
T5680	8463-8466	VB	denotes	are
T5681	8467-8474	DT	denotes	neither
T5682	8475-8484	JJ	denotes	essential
T5683	8485-8488	CC	denotes	nor
T5684	8489-8499	JJ	denotes	sufficient
T5685	8500-8502	TO	denotes	to
T5686	8503-8510	VB	denotes	mediate
T5687	8511-8522	JJ	denotes	BCR-induced
T5688	8523-8527	NN	denotes	NFκB
T5689	8528-8538	NN	denotes	activation
T5690	8539-8541	IN	denotes	in
T5691	8542-8546	NN	denotes	DT40
T5692	8547-8548	NN	denotes	B
T5693	8549-8554	NN	denotes	cells
T5694	8555-8558	CC	denotes	and
T5695	8559-8564	RB	denotes	hence
T5696	8565-8567	VB	denotes	do
T5697	8568-8571	RB	denotes	not
T5698	8572-8583	VB	denotes	participate
T5699	8584-8586	IN	denotes	in
T5700	8587-8594	NN	denotes	DAG/PKC
T5701	8595-8603	VB	denotes	mediated
T5702	8604-8611	NN	denotes	control
T5703	8612-8614	IN	denotes	of
T5704	8615-8619	NN	denotes	NFκB
R1889	T2291	T2289	arg2Of	phosphorylation,of
R1890	T2291	T2290	arg1Of	phosphorylation,HSP27
R1891	T2295	T2292	arg2Of	cells,in
R1892	T2295	T2293	arg1Of	cells,DT40
R1893	T2295	T2294	arg1Of	cells,B
R1894	T2295	T2296	arg1Of	cells,lacking
R1895	T2297	T2296	arg2Of	expression,lacking
R1896	T2297	T2298	arg1Of	expression,of
R1897	T2301	T2298	arg2Of	kinases,of
R1898	T2301	T2299	arg1Of	kinases,PKD
R1899	T2301	T2300	arg1Of	kinases,family
R1900	T2304	T2302	arg1Of	cells,DT40
R1901	T2304	T2303	arg1Of	cells,B
R1902	T2304	T2305	arg1Of	cells,express
R1903	T2308	T2305	arg2Of	isoforms,express
R1904	T2308	T2306	arg1Of	isoforms,two
R1905	T2308	T2307	arg1Of	isoforms,PKD
R1906	T2308	T2309	arg1Of	isoforms,","
R1907	T2310	T2311	arg1Of	PKD1,and
R1908	T2311	T2309	arg2Of	and,","
R1909	T2311	T2314	arg1Of	and,and
R1910	T2311	T2315	arg1Of	and,as
R1911	T2312	T2311	arg2Of	PKD3,and
R1912	T2314	T2313	arg1Of	and,","
R1913	T2317	T2315	arg2Of	described,as
R1914	T2317	T2316	arg1Of	described,previously
R1915	T2318	T2319	arg1Of	we,have
R1916	T2318	T2321	arg1Of	we,generated
R1917	T2321	T2317	arg3Of	generated,described
R1918	T2321	T2319	arg2Of	generated,have
R1919	T2321	T2320	arg1Of	generated,recently
R1920	T2321	T2337	arg1Of	generated,[
R1921	T2325	T2321	arg2Of	lines,generated
R1922	T2325	T2322	arg1Of	lines,DT40
R1923	T2325	T2323	arg1Of	lines,B
R1924	T2325	T2324	arg1Of	lines,cell
R1925	T2325	T2326	arg1Of	lines,that
R1926	T2325	T2327	arg1Of	lines,lack
R1927	T2328	T2329	arg1Of	expression,of
R1928	T2328	T2334	arg1Of	expression,or
R1929	T2331	T2332	arg1Of	PKD1,or
R1930	T2332	T2329	arg2Of	or,of
R1931	T2332	T2330	arg1Of	or,either
R1932	T2333	T2332	arg2Of	PKD3,or
R1933	T2334	T2327	arg2Of	or,lack
R1934	T2336	T2334	arg2Of	enzymes,or
R1935	T2336	T2335	arg1Of	enzymes,both
R1936	T2338	T2337	arg2Of	1,[
R1937	T2339	T2337	arg3Of	],[
R1938	T2341	T2340	arg2Of	generating,In
R1939	T2346	T2341	arg2Of	lines,generating
R1940	T2346	T2342	arg1Of	lines,the
R1941	T2346	T2343	arg1Of	lines,double
R1942	T2346	T2344	arg1Of	lines,knockout
R1943	T2346	T2345	arg1Of	lines,cell
R1944	T2347	T2348	arg1Of	we,targeted
R1945	T2348	T2340	arg1Of	targeted,In
R1946	T2348	T2352	arg1Of	targeted,in
R1947	T2351	T2348	arg2Of	loci,targeted
R1948	T2351	T2349	arg1Of	loci,the
R1949	T2351	T2350	arg1Of	loci,PKD1
R1950	T2356	T2352	arg2Of	line,in
R1951	T2356	T2353	arg1Of	line,a
R1952	T2356	T2354	arg1Of	line,PKD3−/−
R1953	T2356	T2355	arg1Of	line,cell
R1954	T2356	T2357	arg1Of	line,that
R1955	T2356	T2358	arg1Of	line,expressed
R1956	T2358	T2362	arg1Of	expressed,under
R1957	T2361	T2358	arg2Of	transgene,expressed
R1958	T2361	T2359	arg1Of	transgene,a
R1959	T2361	T2360	arg1Of	transgene,Flag-PKD3
R1960	T2364	T2362	arg2Of	control,under
R1961	T2364	T2363	arg1Of	control,the
R1962	T2364	T2365	arg1Of	control,of
R1963	T2368	T2365	arg2Of	promoter,of
R1964	T2368	T2366	arg1Of	promoter,a
R1965	T2368	T2367	arg1Of	promoter,doxycycline-inducible
R1966	T2373	T2371	arg2Of	presence,in
R1967	T2373	T2372	arg1Of	presence,the
R1968	T2373	T2374	arg1Of	presence,of
R1969	T2375	T2374	arg2Of	doxycycline,of
R1970	T2378	T2377	arg1Of	expression,Flag-PKD3
R1971	T2378	T2379	arg1Of	expression,in
R1972	T2378	T2384	arg1Of	expression,is
R1973	T2378	T2385	arg1Of	expression,comparable
R1974	T2383	T2379	arg2Of	cells,in
R1975	T2383	T2380	arg1Of	cells,PKD1/3
R1976	T2383	T2381	arg1Of	cells,double
R1977	T2383	T2382	arg1Of	cells,knockout
R1978	T2384	T2394	arg1Of	is,and
R1979	T2385	T2384	arg2Of	comparable,is
R1980	T2385	T2386	arg1Of	comparable,to
R1981	T2385	T2390	arg1Of	comparable,in
R1982	T2388	T2386	arg2Of	PKD3,to
R1983	T2388	T2387	arg1Of	PKD3,endogenous
R1984	T2388	T2389	arg1Of	PKD3,present
R1985	T2393	T2390	arg2Of	cells,in
R1986	T2393	T2391	arg1Of	cells,wild-type
R1987	T2393	T2392	arg1Of	cells,DT40
R1988	T2394	T2369	arg1Of	and,Hence
R1989	T2394	T2370	arg1Of	and,","
R1990	T2394	T2371	arg1Of	and,in
R1991	T2394	T2376	arg1Of	and,","
R1992	T2395	T2396	arg1Of	removal,of
R1993	T2395	T2405	arg1Of	removal,results
R1994	T2397	T2396	arg2Of	doxycycline,of
R1995	T2397	T2398	arg1Of	doxycycline,from
R1996	T2397	T2402	arg1Of	doxycycline,for
R1997	T2401	T2398	arg2Of	media,from
R1998	T2401	T2399	arg1Of	media,the
R1999	T2401	T2400	arg1Of	media,culture
R2000	T2404	T2402	arg2Of	days,for
R2001	T2404	T2403	arg1Of	days,5
R2002	T2405	T2394	arg2Of	results,and
R2003	T2405	T2406	arg1Of	results,in
R2004	T2409	T2408	arg1Of	null,completely
R2005	T2411	T2406	arg2Of	phenotype,in
R2006	T2411	T2407	arg1Of	phenotype,a
R2007	T2411	T2409	arg1Of	phenotype,null
R2008	T2411	T2410	arg1Of	phenotype,PKD
R2009	T2411	T2412	arg1Of	phenotype,(
R2010	T2414	T2412	arg2Of	1A,(
R2011	T2414	T2413	arg1Of	1A,Fig.
R2012	T2415	T2412	arg3Of	),(
R2013	T2418	T2419	arg1Of	we,have
R2014	T2418	T2420	arg1Of	we,demonstrated
R2015	T2420	T2416	arg1Of	demonstrated,Previously
R2016	T2420	T2417	arg1Of	demonstrated,","
R2017	T2420	T2419	arg2Of	demonstrated,have
R2018	T2422	T2423	arg1Of	phosphorylation,and
R2019	T2423	T2426	arg1Of	and,of
R2020	T2423	T2437	arg1Of	and,is
R2021	T2423	T2438	arg1Of	and,defective
R2022	T2423	T2444	arg1Of	and,can
R2023	T2423	T2445	arg1Of	and,restored
R2024	T2425	T2423	arg2Of	exclusion,and
R2025	T2425	T2424	arg1Of	exclusion,nuclear
R2026	T2430	T2426	arg2Of	deacetylases,of
R2027	T2430	T2427	arg1Of	deacetylases,class
R2028	T2430	T2428	arg1Of	deacetylases,II
R2029	T2430	T2429	arg1Of	deacetylases,histone
R2030	T2430	T2431	arg1Of	deacetylases,(
R2031	T2430	T2434	arg1Of	deacetylases,during
R2032	T2432	T2431	arg2Of	HDACs,(
R2033	T2433	T2431	arg3Of	),(
R2034	T2436	T2434	arg2Of	engagement,during
R2035	T2436	T2435	arg1Of	engagement,BCR
R2036	T2437	T2443	arg1Of	is,and
R2037	T2438	T2437	arg2Of	defective,is
R2038	T2438	T2439	arg1Of	defective,in
R2039	T2442	T2439	arg2Of	cells,in
R2040	T2442	T2440	arg1Of	cells,PKD1/3−/−
R2041	T2442	T2441	arg1Of	cells,B
R2042	T2443	T2420	arg2Of	and,demonstrated
R2043	T2443	T2421	arg1Of	and,that
R2044	T2445	T2443	arg2Of	restored,and
R2045	T2445	T2444	arg2Of	restored,can
R2046	T2445	T2446	arg1Of	restored,upon
R2047	T2447	T2446	arg2Of	re-expression,upon
R2048	T2447	T2448	arg1Of	re-expression,of
R2049	T2452	T2448	arg2Of	isoform,of
R2050	T2452	T2449	arg1Of	isoform,a
R2051	T2452	T2450	arg1Of	isoform,single
R2052	T2452	T2451	arg1Of	isoform,PKD
R2053	T2452	T2453	arg1Of	isoform,[
R2054	T2454	T2453	arg2Of	1,[
R2055	T2455	T2453	arg3Of	],[
R2056	T2461	T2456	arg1Of	HSP27,The
R2057	T2461	T2457	arg1Of	HSP27,small
R2058	T2461	T2458	arg1Of	HSP27,heat
R2059	T2461	T2459	arg1Of	HSP27,shock
R2060	T2461	T2460	arg1Of	HSP27,protein
R2061	T2461	T2462	arg1Of	HSP27,has
R2062	T2461	T2464	arg1Of	HSP27,been
R2063	T2461	T2465	arg2Of	HSP27,proposed
R2064	T2465	T2462	arg2Of	proposed,has
R2065	T2465	T2463	arg1Of	proposed,recently
R2066	T2465	T2464	arg2Of	proposed,been
R2067	T2465	T2466	arg1Of	proposed,as
R2068	T2465	T2470	arg1Of	proposed,[
R2069	T2465	T2473	arg1Of	proposed,and
R2070	T2469	T2466	arg2Of	substrate,as
R2071	T2469	T2467	arg1Of	substrate,a
R2072	T2469	T2468	arg1Of	substrate,PKD1
R2073	T2471	T2470	arg2Of	24,[
R2074	T2472	T2470	arg3Of	],[
R2075	T2474	T2476	arg1Of	we,assessed
R2076	T2476	T2473	arg2Of	assessed,and
R2077	T2476	T2475	arg1Of	assessed,accordingly
R2078	T2480	T2478	arg1Of	cells,PKD-null
R2079	T2480	T2479	arg1Of	cells,DT40
R2080	T2480	T2481	arg1Of	cells,have
R2081	T2481	T2476	arg2Of	have,assessed
R2082	T2481	T2477	arg1Of	have,whether
R2083	T2483	T2481	arg2Of	phosphorylation,have
R2084	T2483	T2482	arg1Of	phosphorylation,defective
R2085	T2483	T2484	arg1Of	phosphorylation,of
R2086	T2485	T2484	arg2Of	HSP27,of
R2087	T2485	T2486	arg1Of	HSP27,on
R2088	T2485	T2489	arg1Of	HSP27,","
R2089	T2487	T2486	arg2Of	serine,on
R2090	T2487	T2488	arg1Of	serine,82
R2091	T2494	T2489	arg2Of	sequence,","
R2092	T2494	T2490	arg1Of	sequence,the
R2093	T2494	T2491	arg2Of	sequence,proposed
R2094	T2494	T2492	arg1Of	sequence,PKD1
R2095	T2494	T2493	arg1Of	sequence,substrate
R2096	T2495	T2497	arg1Of	We,investigated
R2097	T2497	T2496	arg1Of	investigated,initially
R2098	T2499	T2497	arg2Of	regulation,investigated
R2099	T2499	T2498	arg1Of	regulation,the
R2100	T2499	T2500	arg1Of	regulation,of
R2101	T2499	T2503	arg1Of	regulation,in
R2102	T2502	T2500	arg2Of	phosphorylation,of
R2103	T2502	T2501	arg1Of	phosphorylation,HSP27
R2104	T2508	T2503	arg2Of	cells,in
R2105	T2508	T2504	arg1Of	cells,single
R2106	T2508	T2505	arg1Of	cells,knockout
R2107	T2508	T2506	arg1Of	cells,DT40
R2108	T2508	T2507	arg1Of	cells,B
R2109	T2508	T2509	arg1Of	cells,lacking
R2110	T2511	T2512	arg1Of	PKD1,or
R2111	T2512	T2509	arg2Of	or,lacking
R2112	T2512	T2510	arg1Of	or,either
R2113	T2513	T2512	arg2Of	PKD3,or
R2114	T2515	T2514	arg2Of	shown,As
R2115	T2515	T2516	arg1Of	shown,in
R2116	T2518	T2516	arg2Of	1B,in
R2117	T2518	T2517	arg1Of	1B,Fig.
R2118	T2520	T2521	arg1Of	activation,of
R2119	T2520	T2524	arg1Of	activation,or
R2120	T2523	T2521	arg2Of	BCR,of
R2121	T2523	T2522	arg1Of	BCR,the
R2122	T2524	T2530	arg1Of	or,increased
R2123	T2525	T2524	arg2Of	treatment,or
R2124	T2525	T2526	arg1Of	treatment,with
R2125	T2529	T2526	arg2Of	PdBu,with
R2126	T2529	T2527	arg1Of	PdBu,the
R2127	T2529	T2528	arg1Of	PdBu,DAG-mimetic
R2128	T2530	T2514	arg1Of	increased,As
R2129	T2530	T2519	arg1Of	increased,","
R2130	T2532	T2530	arg2Of	levels,increased
R2131	T2532	T2531	arg1Of	levels,the
R2132	T2532	T2533	arg1Of	levels,of
R2133	T2535	T2533	arg2Of	phosphorylation,of
R2134	T2535	T2534	arg1Of	phosphorylation,HSP27
R2135	T2535	T2536	arg1Of	phosphorylation,at
R2136	T2537	T2536	arg2Of	S82,at
R2137	T2537	T2538	arg1Of	S82,in
R2138	T2542	T2538	arg2Of	cells,in
R2139	T2542	T2539	arg1Of	cells,wild-type
R2140	T2542	T2540	arg1Of	cells,DT40
R2141	T2542	T2541	arg1Of	cells,B
R2142	T2543	T2544	arg1Of	BCR,and
R2143	T2545	T2544	arg2Of	phorbol,and
R2144	T2547	T2543	arg1Of	signals,BCR
R2145	T2547	T2545	arg1Of	signals,phorbol
R2146	T2547	T2546	arg1Of	signals,ester
R2147	T2547	T2548	arg1Of	signals,were
R2148	T2547	T2550	arg1Of	signals,able
R2149	T2547	T2552	arg1Of	signals,increase
R2150	T2548	T2549	arg1Of	were,also
R2151	T2550	T2548	arg2Of	able,were
R2152	T2552	T2550	arg2Of	increase,able
R2153	T2552	T2551	arg1Of	increase,to
R2154	T2554	T2552	arg2Of	phosphorylation,increase
R2155	T2554	T2553	arg1Of	phosphorylation,HSP27
R2156	T2554	T2555	arg1Of	phosphorylation,in
R2157	T2556	T2557	arg1Of	PKD1,or
R2158	T2558	T2557	arg2Of	PKD3,or
R2159	T2563	T2555	arg2Of	cells,in
R2160	T2563	T2556	arg1Of	cells,PKD1
R2161	T2563	T2558	arg1Of	cells,PKD3
R2162	T2563	T2559	arg1Of	cells,single
R2163	T2563	T2560	arg1Of	cells,knockout
R2164	T2563	T2561	arg1Of	cells,DT40
R2165	T2563	T2562	arg1Of	cells,B
R2166	T2563	T2564	arg1Of	cells,(
R2167	T2566	T2564	arg2Of	1B,(
R2168	T2566	T2565	arg1Of	1B,Fig.
R2169	T2567	T2564	arg3Of	),(
R2170	T2570	T2571	arg1Of	BCR-,and
R2171	T2571	T2577	arg1Of	and,on
R2172	T2571	T2579	arg1Of	and,was
R2173	T2571	T2580	arg2Of	and,abolished
R2174	T2573	T2572	arg1Of	ester-induced,phorbol
R2175	T2574	T2571	arg2Of	phosphorylation,and
R2176	T2574	T2573	arg1Of	phosphorylation,ester-induced
R2177	T2574	T2575	arg1Of	phosphorylation,of
R2178	T2576	T2575	arg2Of	HSP27,of
R2179	T2578	T2577	arg2Of	S82,on
R2180	T2580	T2568	arg1Of	abolished,However
R2181	T2580	T2569	arg1Of	abolished,","
R2182	T2580	T2579	arg2Of	abolished,was
R2183	T2580	T2581	arg1Of	abolished,in
R2184	T2583	T2581	arg2Of	cells,in
R2185	T2583	T2582	arg1Of	cells,B
R2186	T2583	T2584	arg1Of	cells,that
R2187	T2583	T2585	arg1Of	cells,lacked
R2188	T2587	T2588	arg1Of	PKD1,and
R2189	T2588	T2585	arg2Of	and,lacked
R2190	T2588	T2586	arg1Of	and,both
R2191	T2588	T2590	arg1Of	and,(
R2192	T2589	T2588	arg2Of	PKD3,and
R2193	T2592	T2590	arg2Of	1C,(
R2194	T2592	T2591	arg1Of	1C,Fig.
R2195	T2593	T2590	arg3Of	),(
R2196	T2597	T2596	arg1Of	expression,doxycycline-induced
R2197	T2597	T2598	arg1Of	expression,of
R2198	T2597	T2602	arg1Of	expression,in
R2199	T2597	T2607	arg1Of	expression,was
R2200	T2597	T2608	arg1Of	expression,sufficient
R2201	T2601	T2598	arg2Of	transgene,of
R2202	T2601	T2599	arg1Of	transgene,the
R2203	T2601	T2600	arg1Of	transgene,Flag-PKD3
R2204	T2606	T2602	arg2Of	cells,in
R2205	T2606	T2603	arg1Of	cells,the
R2206	T2606	T2604	arg1Of	cells,double
R2207	T2606	T2605	arg1Of	cells,knockout
R2208	T2607	T2594	arg1Of	was,Significantly
R2209	T2607	T2595	arg1Of	was,","
R2210	T2607	T2609	modOf	was,to
R2211	T2608	T2607	arg2Of	sufficient,was
R2212	T2610	T2609	arg1Of	restore,to
R2213	T2612	T2610	arg2Of	regulation,restore
R2214	T2612	T2611	arg1Of	regulation,normal
R2215	T2612	T2613	arg1Of	regulation,of
R2216	T2615	T2613	arg2Of	phosphorylation,of
R2217	T2615	T2614	arg1Of	phosphorylation,HSP27
R2218	T2615	T2616	arg1Of	phosphorylation,(
R2219	T2618	T2616	arg2Of	1C,(
R2220	T2618	T2617	arg1Of	1C,Fig.
R2221	T2619	T2616	arg3Of	),(
R2222	T2621	T2620	arg2Of	contrast,In
R2223	T2623	T2624	arg1Of	expression,of
R2224	T2623	T2630	arg1Of	expression,in
R2225	T2623	T2635	arg1Of	expression,was
R2226	T2623	T2637	arg1Of	expression,able
R2227	T2623	T2639	arg1Of	expression,restore
R2228	T2629	T2624	arg2Of	protein,of
R2229	T2629	T2625	arg1Of	protein,a
R2230	T2629	T2626	arg1Of	protein,kinase-deficient
R2231	T2629	T2627	arg1Of	protein,PKD3
R2232	T2629	T2628	arg1Of	protein,mutant
R2233	T2634	T2630	arg2Of	cells,in
R2234	T2634	T2631	arg1Of	cells,the
R2235	T2634	T2632	arg1Of	cells,double
R2236	T2634	T2633	arg1Of	cells,knockout
R2237	T2635	T2620	arg1Of	was,In
R2238	T2635	T2622	arg1Of	was,","
R2239	T2635	T2636	arg1Of	was,not
R2240	T2637	T2635	arg2Of	able,was
R2241	T2639	T2637	arg2Of	restore,able
R2242	T2639	T2638	arg1Of	restore,to
R2243	T2640	T2641	arg1Of	BCR-,or
R2244	T2641	T2639	arg2Of	or,restore
R2245	T2645	T2641	arg2Of	phosphorylation,or
R2246	T2645	T2642	arg1Of	phosphorylation,phorbol
R2247	T2645	T2643	arg1Of	phosphorylation,ester-induced
R2248	T2645	T2644	arg1Of	phosphorylation,HSP27
R2249	T2645	T2646	arg1Of	phosphorylation,(
R2250	T2648	T2646	arg2Of	1D,(
R2251	T2648	T2647	arg1Of	1D,Fig.
R2252	T2649	T2646	arg3Of	),(
R2253	T2652	T2655	arg1Of	PKD3,as
R2254	T2655	T2653	arg1Of	as,as
R2255	T2655	T2654	arg1Of	as,well
R2256	T2655	T2657	arg1Of	as,can
R2257	T2655	T2658	arg1Of	as,regulate
R2258	T2656	T2655	arg2Of	PKD1,as
R2259	T2658	T2657	arg2Of	regulate,can
R2260	T2658	T2661	arg1Of	regulate,and
R2261	T2660	T2658	arg2Of	phosphorylation,regulate
R2262	T2660	T2659	arg1Of	phosphorylation,HSP27
R2263	T2661	T2650	arg1Of	and,Hence
R2264	T2661	T2651	arg1Of	and,","
R2265	T2665	T2662	arg2Of	cells,in
R2266	T2665	T2663	arg1Of	cells,DT40
R2267	T2665	T2664	arg1Of	cells,B
R2268	T2666	T2667	arg1Of	they,are
R2269	T2666	T2669	arg2Of	they,redundant
R2270	T2669	T2661	arg2Of	redundant,and
R2271	T2669	T2662	arg1Of	redundant,in
R2272	T2669	T2667	arg2Of	redundant,are
R2273	T2669	T2668	arg1Of	redundant,functionally
R2274	T2669	T2670	arg1Of	redundant,as
R2275	T2672	T2670	arg2Of	kinases,as
R2276	T2672	T2671	arg1Of	kinases,HSP27
R3056	T3837	T3838	arg1Of	proliferation,and
R3058	T3838	T3840	arg1Of	and,in
R3059	T3839	T3838	arg2Of	survival,and
R3060	T3843	T3840	arg2Of	cells,in
R3061	T3843	T3841	arg1Of	cells,DT40
R3062	T3843	T3842	arg1Of	cells,B
R3063	T3843	T3844	arg1Of	cells,lacking
R3064	T3845	T3844	arg2Of	expression,lacking
R3065	T3845	T3846	arg1Of	expression,of
R3066	T3849	T3846	arg2Of	kinases,of
R3067	T3849	T3847	arg1Of	kinases,PKD
R3068	T3849	T3848	arg1Of	kinases,family
R3069	T3851	T3850	arg1Of	enzymes,PKD
R3070	T3851	T3852	arg1Of	enzymes,have
R3071	T3851	T3854	arg1Of	enzymes,been
R3072	T3851	T3855	arg2Of	enzymes,linked
R3073	T3855	T3852	arg2Of	linked,have
R3074	T3855	T3853	arg1Of	linked,previously
R3075	T3855	T3854	arg2Of	linked,been
R3076	T3855	T3856	arg1Of	linked,to
R3077	T3858	T3856	arg2Of	regulation,to
R3078	T3858	T3857	arg1Of	regulation,the
R3079	T3858	T3859	arg1Of	regulation,of
R3080	T3861	T3862	arg1Of	proliferation,and
R3081	T3862	T3859	arg2Of	and,of
R3082	T3862	T3860	arg1Of	and,cell
R3083	T3862	T3864	arg1Of	and,(
R3084	T3863	T3862	arg2Of	survival,and
R3085	T3865	T3864	arg2Of	reviewed,(
R3086	T3865	T3866	arg1Of	reviewed,in
R3087	T3865	T3867	arg1Of	reviewed,[
R3088	T3868	T3867	arg2Of	20,[
R3089	T3869	T3867	arg3Of	],[
R3090	T3870	T3864	arg3Of	),(
R3091	T3872	T3871	arg1Of	investigate,To
R3092	T3874	T3872	arg2Of	effect,investigate
R3093	T3874	T3873	arg1Of	effect,the
R3094	T3876	T3877	arg1Of	loss,of
R3095	T3876	T3880	arg1Of	loss,had
R3096	T3879	T3877	arg2Of	kinases,of
R3097	T3879	T3878	arg1Of	kinases,PKD
R3098	T3880	T3874	arg2Of	had,effect
R3099	T3880	T3875	arg1Of	had,that
R3100	T3880	T3881	arg1Of	had,on
R3101	T3884	T3885	arg1Of	survival,and/or
R3102	T3885	T3881	arg2Of	and/or,on
R3103	T3885	T3882	arg1Of	and/or,B
R3104	T3885	T3883	arg1Of	and/or,cell
R3105	T3886	T3885	arg2Of	proliferation,and/or
R3106	T3887	T3872	arg1Of	we,investigate
R3107	T3887	T3888	arg1Of	we,cultured
R3108	T3888	T3871	modOf	cultured,To
R3109	T3888	T3893	arg1Of	cultured,in
R3110	T3889	T3890	arg1Of	wild-type,and
R3111	T3891	T3890	arg2Of	PKD-null,and
R3112	T3892	T3888	arg2Of	cells,cultured
R3113	T3892	T3889	arg1Of	cells,wild-type
R3114	T3892	T3891	arg1Of	cells,PKD-null
R3115	T3895	T3893	arg2Of	presence,in
R3116	T3895	T3894	arg1Of	presence,the
R3117	T3895	T3896	arg1Of	presence,(
R3118	T3897	T3896	arg2Of	PKD1/3−/−,(
R3119	T3898	T3896	arg3Of	:,(
R3120	T3899	T3900	arg1Of	Flag-PKD3+ve,)
R3121	T3899	T3901	arg1Of	Flag-PKD3+ve,or
R3122	T3901	T3909	arg1Of	or,monitored
R3123	T3902	T3901	arg2Of	absence,or
R3124	T3902	T3903	arg1Of	absence,(
R3125	T3902	T3906	arg1Of	absence,of
R3126	T3904	T3903	arg2Of	PKD1/3−/−,(
R3127	T3905	T3903	arg3Of	),(
R3128	T3907	T3906	arg2Of	doxycycline,of
R3129	T3909	T3908	arg1Of	monitored,and
R3130	T3911	T3909	arg2Of	growth,monitored
R3131	T3911	T3910	arg1Of	growth,exponential
R3132	T3913	T3912	arg2Of	shown,As
R3133	T3913	T3914	arg1Of	shown,in
R3134	T3916	T3914	arg2Of	2A,in
R3135	T3916	T3915	arg1Of	2A,Fig.
R3136	T3919	T3918	arg1Of	cells,PKD1/3−/−
R3137	T3919	T3920	arg1Of	cells,proliferated
R3138	T3920	T3921	arg1Of	proliferated,exponentially
R3139	T3920	T3922	arg1Of	proliferated,and
R3140	T3922	T3912	arg1Of	and,As
R3141	T3922	T3917	arg1Of	and,","
R3142	T3923	T3924	arg1Of	re-expression,of
R3143	T3923	T3926	arg1Of	re-expression,in
R3144	T3923	T3929	arg1Of	re-expression,had
R3145	T3925	T3924	arg2Of	Flag-PKD3,of
R3146	T3928	T3926	arg2Of	cells,in
R3147	T3928	T3927	arg1Of	cells,these
R3148	T3929	T3922	arg2Of	had,and
R3149	T3931	T3929	arg2Of	impact,had
R3150	T3931	T3930	arg1Of	impact,no
R3151	T3931	T3932	arg1Of	impact,on
R3152	T3934	T3932	arg2Of	rate,on
R3153	T3934	T3933	arg1Of	rate,the
R3154	T3934	T3935	arg1Of	rate,of
R3155	T3936	T3935	arg2Of	proliferation,of
R3156	T3940	T3939	arg1Of	viability,the
R3157	T3940	T3941	arg1Of	viability,of
R3158	T3940	T3945	arg1Of	viability,during
R3159	T3940	T3948	arg1Of	viability,was
R3160	T3940	T3951	arg1Of	viability,different
R3161	T3944	T3941	arg2Of	cells,of
R3162	T3944	T3942	arg1Of	cells,PKD1/3−/−
R3163	T3944	T3943	arg1Of	cells,B
R3164	T3947	T3945	arg2Of	culturing,during
R3165	T3947	T3946	arg1Of	culturing,routine
R3166	T3948	T3937	arg1Of	was,Furthermore
R3167	T3948	T3938	arg1Of	was,","
R3168	T3948	T3949	arg1Of	was,not
R3169	T3951	T3948	arg2Of	different,was
R3170	T3951	T3950	arg1Of	different,significantly
R3171	T3951	T3952	arg1Of	different,from
R3172	T3953	T3952	arg2Of	that,from
R3173	T3953	T3954	arg1Of	that,of
R3174	T3957	T3954	arg2Of	cells,of
R3175	T3957	T3955	arg1Of	cells,wild-type
R3176	T3957	T3956	arg1Of	cells,B
R3177	T3957	T3958	arg1Of	cells,(
R3178	T3959	T3958	arg2Of	data,(
R3179	T3959	T3961	arg2Of	data,shown
R3180	T3961	T3960	arg1Of	shown,not
R3181	T3962	T3958	arg3Of	),(
R3182	T3963	T3964	arg1Of	It,was
R3183	T3963	T3965	arg2Of	It,noted
R3184	T3965	T3964	arg2Of	noted,was
R3185	T3970	T3967	arg1Of	time,the
R3186	T3970	T3968	arg1Of	time,population
R3187	T3970	T3969	arg1Of	time,doubling
R3188	T3970	T3971	arg1Of	time,of
R3189	T3970	T3974	arg1Of	time,was
R3190	T3970	T3976	arg1Of	time,slower
R3191	T3973	T3971	arg2Of	cells,of
R3192	T3973	T3972	arg1Of	cells,PKD1/3−/−
R3193	T3974	T3989	arg1Of	was,but
R3194	T3976	T3974	arg2Of	slower,was
R3195	T3976	T3975	arg1Of	slower,slightly
R3196	T3976	T3977	arg1Of	slower,than
R3197	T3978	T3977	arg2Of	that,than
R3198	T3978	T3979	arg1Of	that,of
R3199	T3983	T3979	arg2Of	cells,of
R3200	T3983	T3980	arg1Of	cells,wild
R3201	T3983	T3981	arg1Of	cells,type
R3202	T3983	T3982	arg1Of	cells,DT40
R3203	T3983	T3984	arg1Of	cells,(
R3204	T3985	T3984	arg2Of	12.7 ± 2.8 h,(
R3205	T3985	T3986	arg1Of	12.7 ± 2.8 h,versus
R3206	T3987	T3986	arg2Of	10.2 ± 0.4 h,versus
R3207	T3988	T3984	arg3Of	),(
R3208	T3989	T3965	arg3Of	but,noted
R3209	T3989	T3966	arg1Of	but,that
R3210	T3991	T3990	arg1Of	failure,the
R3211	T3991	T3992	arg1Of	failure,of
R3212	T3991	T3995	modOf	failure,to
R3213	T3991	T4003	arg1Of	failure,suggests
R3214	T3994	T3992	arg2Of	re-expression,of
R3215	T3994	T3993	arg1Of	re-expression,PKD3
R3216	T3996	T3995	arg1Of	modify,to
R3217	T3999	T3996	arg2Of	rate,modify
R3218	T3999	T3997	arg1Of	rate,the
R3219	T3999	T3998	arg1Of	rate,proliferation
R3220	T3999	T4000	arg1Of	rate,of
R3221	T4002	T4000	arg2Of	cells,of
R3222	T4002	T4001	arg1Of	cells,PKD1/3−/−
R3223	T4003	T3989	arg2Of	suggests,but
R3224	T4007	T4005	arg1Of	differences,these
R3225	T4007	T4006	arg1Of	differences,small
R3226	T4007	T4008	arg1Of	differences,were
R3227	T4007	T4017	arg1Of	differences,were
R3228	T4007	T4019	arg2Of	differences,caused
R3229	T4008	T4010	arg1Of	were,likely
R3230	T4008	T4016	arg1Of	were,and
R3231	T4010	T4009	arg1Of	likely,most
R3232	T4012	T4008	arg2Of	result,were
R3233	T4012	T4011	arg1Of	result,the
R3234	T4012	T4013	arg1Of	result,of
R3235	T4015	T4013	arg2Of	variation,of
R3236	T4015	T4014	arg1Of	variation,clonal
R3237	T4016	T4003	arg2Of	and,suggests
R3238	T4016	T4004	arg1Of	and,that
R3239	T4019	T4016	arg2Of	caused,and
R3240	T4019	T4017	arg2Of	caused,were
R3241	T4019	T4018	arg1Of	caused,not
R3242	T4019	T4020	arg1Of	caused,specifically
R3243	T4022	T4019	arg1Of	loss,caused
R3244	T4022	T4021	arg2Of	loss,by
R3245	T4022	T4023	arg1Of	loss,of
R3246	T4025	T4023	arg2Of	enzymes,of
R3247	T4025	T4024	arg1Of	enzymes,PKD
R3248	T4030	T4028	arg1Of	enzymes,PKD
R3249	T4030	T4029	arg1Of	enzymes,family
R3250	T4030	T4031	arg1Of	enzymes,are
R3251	T4030	T4033	arg1Of	enzymes,essential
R3252	T4031	T4026	arg1Of	are,Thus
R3253	T4031	T4027	arg1Of	are,","
R3254	T4031	T4032	arg1Of	are,not
R3255	T4033	T4031	arg2Of	essential,are
R3256	T4033	T4034	arg1Of	essential,for
R3257	T4035	T4034	arg2Of	regulating,for
R3258	T4037	T4036	arg1Of	survival,basal
R3259	T4037	T4038	arg1Of	survival,and
R3260	T4038	T4035	arg2Of	and,regulating
R3261	T4039	T4038	arg2Of	proliferation,and
R3262	T4039	T4040	arg1Of	proliferation,of
R3263	T4043	T4040	arg2Of	cells,of
R3264	T4043	T4041	arg1Of	cells,DT40
R3265	T4043	T4042	arg1Of	cells,B
R3266	T4045	T4044	arg1Of	enzymes,PKD
R3267	T4045	T4046	arg1Of	enzymes,","
R3268	T4045	T4052	arg1Of	enzymes,have
R3269	T4045	T4054	arg1Of	enzymes,been
R3270	T4045	T4055	arg2Of	enzymes,linked
R3271	T4048	T4049	arg1Of	PKD1,and
R3272	T4049	T4046	arg2Of	and,","
R3273	T4049	T4047	arg1Of	and,specifically
R3274	T4050	T4049	arg2Of	PKD2,and
R3275	T4055	T4051	arg1Of	linked,","
R3276	T4055	T4052	arg2Of	linked,have
R3277	T4055	T4053	arg1Of	linked,previously
R3278	T4055	T4054	arg2Of	linked,been
R3279	T4055	T4056	arg1Of	linked,to
R3280	T4059	T4056	arg2Of	role,to
R3281	T4059	T4057	arg1Of	role,a
R3282	T4059	T4058	arg1Of	role,protective
R3283	T4059	T4060	arg1Of	role,against
R3284	T4062	T4061	arg1Of	stress-induced,oxidative
R3285	T4063	T4060	arg2Of	injury,against
R3286	T4063	T4062	arg1Of	injury,stress-induced
R3287	T4063	T4064	arg1Of	injury,in
R3288	T4066	T4067	arg1Of	fibroblast,","
R3289	T4068	T4067	arg2Of	HeLa,","
R3290	T4072	T4064	arg2Of	lines,in
R3291	T4072	T4065	arg1Of	lines,3T3
R3292	T4072	T4066	arg1Of	lines,fibroblast
R3293	T4072	T4068	arg1Of	lines,HeLa
R3294	T4072	T4069	arg1Of	lines,and
R3295	T4072	T4070	arg1Of	lines,epithelial
R3296	T4072	T4071	arg1Of	lines,cell
R3297	T4072	T4073	arg1Of	lines,[
R3298	T4074	T4073	arg2Of	"17,30–32",[
R3299	T4075	T4073	arg3Of	],[
R3300	T4076	T4078	arg1Of	We,addressed
R3301	T4078	T4077	arg1Of	addressed,therefore
R3302	T4080	T4078	arg2Of	role,addressed
R3303	T4080	T4079	arg1Of	role,the
R3304	T4080	T4081	arg1Of	role,of
R3305	T4080	T4085	arg1Of	role,in
R3306	T4084	T4081	arg2Of	kinases,of
R3307	T4084	T4082	arg1Of	kinases,PKD
R3308	T4084	T4083	arg1Of	kinases,family
R3309	T4086	T4085	arg2Of	regulating,in
R3310	T4086	T4090	arg1Of	regulating,in
R3311	T4089	T4086	arg2Of	survival,regulating
R3312	T4089	T4087	arg1Of	survival,B
R3313	T4089	T4088	arg1Of	survival,cell
R3314	T4090	T4092	arg1Of	in,to
R3315	T4091	T4090	arg2Of	response,in
R3316	T4094	T4093	arg1Of	stress,oxidative
R3317	T4094	T4095	arg1Of	stress,and
R3318	T4095	T4090	arg3Of	and,in
R3319	T4098	T4095	arg2Of	stimuli,and
R3320	T4098	T4096	arg1Of	stimuli,other
R3321	T4098	T4097	arg1Of	stimuli,stress
R3322	T4100	T4099	arg2Of	shown,As
R3323	T4100	T4101	arg1Of	shown,in
R3324	T4103	T4101	arg2Of	2B,in
R3325	T4103	T4102	arg1Of	2B,Fig.
R3326	T4105	T4106	arg1Of	loss,of
R3327	T4105	T4109	arg1Of	loss,had
R3328	T4108	T4106	arg2Of	expression,of
R3329	T4108	T4107	arg1Of	expression,PKD1/3
R3330	T4109	T4099	arg1Of	had,As
R3331	T4109	T4104	arg1Of	had,","
R3332	T4109	T4113	arg1Of	had,on
R3333	T4109	T4120	arg1Of	had,in
R3334	T4109	T4153	arg1Of	had,following
R3335	T4112	T4109	arg2Of	impact,had
R3336	T4112	T4110	arg1Of	impact,no
R3337	T4112	T4111	arg1Of	impact,significant
R3338	T4115	T4113	arg2Of	survival,on
R3339	T4115	T4114	arg1Of	survival,the
R3340	T4115	T4116	arg1Of	survival,of
R3341	T4119	T4116	arg2Of	cells,of
R3342	T4119	T4117	arg1Of	cells,DT40
R3343	T4119	T4118	arg1Of	cells,B
R3344	T4120	T4122	arg1Of	in,to
R3345	T4120	T4152	arg1Of	in,or
R3346	T4121	T4120	arg2Of	response,in
R3347	T4125	T4123	arg1Of	stimuli,mitochondrial
R3348	T4125	T4124	arg1Of	stimuli,stress
R3349	T4125	T4126	arg1Of	stimuli,(
R3350	T4125	T4132	arg1Of	stimuli,;
R3351	T4127	T4128	arg1Of	H2O2,or
R3352	T4128	T4126	arg2Of	or,(
R3353	T4130	T4128	arg2Of	deprivation,or
R3354	T4130	T4129	arg1Of	deprivation,serum
R3355	T4131	T4126	arg3Of	),(
R3356	T4132	T4141	arg1Of	;,;
R3357	T4135	T4132	arg2Of	agents,;
R3358	T4135	T4133	arg1Of	agents,DNA
R3359	T4135	T4134	arg1Of	agents,damaging
R3360	T4135	T4136	arg1Of	agents,(
R3361	T4137	T4138	arg1Of	etoposide,or
R3362	T4138	T4136	arg2Of	or,(
R3363	T4139	T4138	arg2Of	doxorubicin,or
R3364	T4140	T4136	arg3Of	),(
R3365	T4141	T4120	arg3Of	;,in
R3366	T4144	T4141	arg2Of	stress,;
R3367	T4144	T4142	arg1Of	stress,ER
R3368	T4144	T4143	arg1Of	stress,pathway
R3369	T4144	T4145	arg1Of	stress,due
R3370	T4145	T4146	arg1Of	due,to
R3371	T4148	T4145	arg2Of	overload,due
R3372	T4148	T4147	arg1Of	overload,calcium
R3373	T4148	T4149	arg1Of	overload,(
R3374	T4150	T4149	arg2Of	thapsigargin,(
R3375	T4151	T4149	arg3Of	),(
R3376	T4153	T4152	arg2Of	following,or
R3377	T4155	T4153	arg2Of	treatment,following
R3378	T4155	T4154	arg2Of	treatment,prolonged
R3379	T4155	T4156	arg1Of	treatment,with
R3380	T4158	T4157	arg1Of	esters,phorbol
R3381	T4158	T4159	arg1Of	esters,or
R3382	T4159	T4156	arg2Of	or,with
R3383	T4159	T4162	arg1Of	or,","
R3384	T4161	T4159	arg2Of	A,or
R3385	T4161	T4160	arg1Of	A,Trichostatin
R3386	T4164	T4162	arg2Of	inhibitor,","
R3387	T4164	T4163	arg1Of	inhibitor,an
R3388	T4164	T4165	arg1Of	inhibitor,of
R3389	T4168	T4165	arg2Of	HDACs,of
R3390	T4168	T4166	arg1Of	HDACs,class
R3391	T4168	T4167	arg1Of	HDACs,I/II
R3392	T4172	T4171	arg1Of	kinases,PKD
R3393	T4172	T4173	arg1Of	kinases,do
R3394	T4172	T4175	arg1Of	kinases,play
R3395	T4175	T4169	arg1Of	play,Thus
R3396	T4175	T4170	arg1Of	play,","
R3397	T4175	T4173	arg2Of	play,do
R3398	T4175	T4174	arg1Of	play,not
R3399	T4175	T4179	arg1Of	play,in
R3400	T4178	T4175	arg2Of	role,play
R3401	T4178	T4176	arg1Of	role,an
R3402	T4178	T4177	arg1Of	role,essential
R3403	T4180	T4179	arg2Of	regulating,in
R3404	T4180	T4184	arg1Of	regulating,in
R3405	T4183	T4180	arg2Of	survival,regulating
R3406	T4183	T4181	arg1Of	survival,B
R3407	T4183	T4182	arg1Of	survival,cell
R3408	T4184	T4186	arg1Of	in,to
R3409	T4185	T4184	arg2Of	response,in
R3410	T4188	T4184	arg3Of	range,in
R3411	T4188	T4187	arg1Of	range,a
R3412	T4188	T4189	arg1Of	range,of
R3413	T4192	T4189	arg2Of	stimuli,of
R3414	T4192	T4190	arg1Of	stimuli,different
R3415	T4192	T4191	arg1Of	stimuli,stress
R3932	T5032	T5033	arg1Of	receptor,regulated
R3933	T5035	T5033	arg2Of	pathways,regulated
R3934	T5035	T5034	arg1Of	pathways,signalling
R3935	T5035	T5036	arg1Of	pathways,in
R3936	T5040	T5036	arg2Of	cells,in
R3937	T5040	T5037	arg1Of	cells,PKD-null
R3938	T5040	T5038	arg1Of	cells,DT40
R3939	T5040	T5039	arg1Of	cells,B
R3940	T5043	T5041	arg1Of	explore,To
R3941	T5043	T5042	arg1Of	explore,further
R3942	T5045	T5043	arg2Of	contribution,explore
R3943	T5045	T5044	arg1Of	contribution,the
R3944	T5045	T5046	arg1Of	contribution,of
R3945	T5045	T5049	arg1Of	contribution,to
R3946	T5048	T5046	arg2Of	kinases,of
R3947	T5048	T5047	arg1Of	kinases,PKD
R3948	T5053	T5049	arg2Of	biology,to
R3949	T5053	T5050	arg1Of	biology,DT40
R3950	T5053	T5051	arg1Of	biology,B
R3951	T5053	T5052	arg1Of	biology,cell
R3952	T5054	T5043	arg1Of	we,explore
R3953	T5054	T5055	arg1Of	we,investigated
R3954	T5055	T5041	modOf	investigated,To
R3955	T5058	T5057	arg1Of	BCR-regulated,specific
R3956	T5060	T5058	arg1Of	events,BCR-regulated
R3957	T5060	T5059	arg1Of	events,signalling
R3958	T5060	T5061	arg1Of	events,were
R3959	T5060	T5062	arg1Of	events,defective
R3960	T5061	T5055	arg2Of	were,investigated
R3961	T5061	T5056	arg1Of	were,whether
R3962	T5062	T5061	arg2Of	defective,were
R3963	T5062	T5063	arg1Of	defective,in
R3964	T5067	T5063	arg2Of	cells,in
R3965	T5067	T5064	arg1Of	cells,the
R3966	T5067	T5065	arg1Of	cells,PKD-null
R3967	T5067	T5066	arg1Of	cells,B
R3968	T5069	T5068	arg1Of	experiments,Initial
R3969	T5069	T5070	arg1Of	experiments,revealed
R3970	T5073	T5072	arg1Of	expression,surface
R3971	T5073	T5074	arg1Of	expression,of
R3972	T5073	T5077	arg1Of	expression,was
R3973	T5073	T5078	arg2Of	expression,reduced
R3974	T5076	T5074	arg2Of	BCR,of
R3975	T5076	T5075	arg1Of	BCR,the
R3976	T5078	T5070	arg2Of	reduced,revealed
R3977	T5078	T5071	arg1Of	reduced,that
R3978	T5078	T5077	arg2Of	reduced,was
R3979	T5078	T5079	arg1Of	reduced,in
R3980	T5078	T5089	arg1Of	reduced,compared
R3981	T5080	T5081	arg1Of	PKD1/3−/−,(
R3982	T5083	T5081	arg2Of	in,(
R3983	T5083	T5082	arg1Of	in,and
R3984	T5084	T5083	arg2Of	PKD1/3−/−,in
R3985	T5084	T5085	arg1Of	PKD1/3−/−,:
R3986	T5084	T5086	arg1Of	PKD1/3−/−,Flag-PKD3+ve
R3987	T5087	T5081	arg3Of	),(
R3988	T5088	T5079	arg2Of	cells,in
R3989	T5088	T5080	arg1Of	cells,PKD1/3−/−
R3990	T5090	T5089	arg2Of	to,compared
R3991	T5094	T5090	arg2Of	cells,to
R3992	T5094	T5091	arg1Of	cells,wild-type
R3993	T5094	T5092	arg1Of	cells,DT40
R3994	T5094	T5093	arg1Of	cells,B
R3995	T5094	T5095	arg1Of	cells,(
R3996	T5097	T5096	arg1Of	3A,Fig.
R3997	T5097	T5098	arg1Of	3A,and
R3998	T5098	T5095	arg2Of	and,(
R3999	T5099	T5098	arg2Of	data,and
R4000	T5099	T5101	arg2Of	data,shown
R4001	T5101	T5100	arg1Of	shown,not
R4002	T5102	T5095	arg3Of	),(
R4003	T5105	T5106	arg1Of	BCR-crosslinking,of
R4004	T5105	T5109	arg1Of	BCR-crosslinking,was
R4005	T5105	T5110	arg1Of	BCR-crosslinking,sufficient
R4006	T5105	T5112	arg1Of	BCR-crosslinking,induce
R4007	T5108	T5106	arg2Of	cells,of
R4008	T5108	T5107	arg1Of	cells,PKD1/3−/−
R4009	T5109	T5103	arg1Of	was,Nevertheless
R4010	T5109	T5104	arg1Of	was,","
R4011	T5110	T5109	arg2Of	sufficient,was
R4012	T5112	T5110	arg2Of	induce,sufficient
R4013	T5112	T5111	arg1Of	induce,to
R4014	T5114	T5112	arg2Of	activation,induce
R4015	T5114	T5113	arg1Of	activation,the
R4016	T5114	T5115	arg1Of	activation,of
R4017	T5117	T5115	arg2Of	number,of
R4018	T5117	T5116	arg1Of	number,a
R4019	T5117	T5118	arg1Of	number,of
R4020	T5117	T5121	arg1Of	number,","
R4021	T5117	T5122	arg1Of	number,similar
R4022	T5120	T5118	arg2Of	cascades,of
R4023	T5120	T5119	arg1Of	cascades,signalling
R4024	T5122	T5123	arg1Of	similar,to
R4025	T5124	T5123	arg2Of	that,to
R4026	T5124	T5125	arg2Of	that,observed
R4027	T5125	T5126	arg1Of	observed,in
R4028	T5128	T5126	arg2Of	cells,in
R4029	T5128	T5127	arg1Of	cells,wild-type
R4030	T5128	T5129	arg1Of	cells,(
R4031	T5131	T5129	arg2Of	3B,(
R4032	T5131	T5130	arg1Of	3B,Fig.
R4033	T5132	T5129	arg3Of	),(
R4034	T5136	T5135	arg1Of	activation,BCR-induced
R4035	T5136	T5137	arg1Of	activation,of
R4036	T5136	T5140	arg1Of	activation,","
R4037	T5139	T5137	arg2Of	Akt,of
R4038	T5139	T5138	arg1Of	Akt,the
R4039	T5140	T5153	arg1Of	",",and
R4040	T5143	T5140	arg2Of	kinase,","
R4041	T5143	T5141	arg1Of	kinase,mTOR/p70
R4042	T5143	T5142	arg1Of	kinase,S6
R4043	T5143	T5144	arg1Of	kinase,(
R4044	T5143	T5145	arg1Of	kinase,as
R4045	T5143	T5152	arg1Of	kinase,)
R4046	T5146	T5145	arg2Of	shown,as
R4047	T5151	T5146	arg1Of	phosphorylation,shown
R4048	T5151	T5147	arg2Of	phosphorylation,by
R4049	T5151	T5148	arg1Of	phosphorylation,S6
R4050	T5151	T5149	arg1Of	phosphorylation,ribosomal
R4051	T5151	T5150	arg1Of	phosphorylation,protein
R4052	T5153	T5157	arg1Of	and,was
R4053	T5153	T5159	arg1Of	and,detectable
R4054	T5156	T5153	arg2Of	pathways,and
R4055	T5156	T5154	arg1Of	pathways,MAPK
R4056	T5156	T5155	arg1Of	pathways,signalling
R4057	T5157	T5133	arg1Of	was,Hence
R4058	T5157	T5134	arg1Of	was,","
R4059	T5159	T5157	arg2Of	detectable,was
R4060	T5159	T5158	arg1Of	detectable,clearly
R4061	T5159	T5160	arg1Of	detectable,in
R4062	T5163	T5160	arg2Of	cells,in
R4063	T5163	T5161	arg1Of	cells,PKD1/3-null
R4064	T5163	T5162	arg1Of	cells,B
R4065	T5163	T5164	arg1Of	cells,(
R4066	T5166	T5164	arg2Of	3B,(
R4067	T5166	T5165	arg1Of	3B,Fig.
R4068	T5167	T5164	arg3Of	),(
R4069	T5172	T5170	arg2Of	phosphorylation,enhanced
R4070	T5172	T5171	arg1Of	phosphorylation,tyrosine
R4071	T5172	T5173	arg1Of	phosphorylation,of
R4072	T5172	T5179	arg1Of	phosphorylation,as
R4073	T5176	T5173	arg2Of	proteins,of
R4074	T5176	T5174	arg1Of	proteins,multiple
R4075	T5176	T5175	arg1Of	proteins,cellular
R4076	T5179	T5177	arg1Of	as,as
R4077	T5179	T5178	arg1Of	as,well
R4078	T5179	T5186	arg1Of	as,was
R4079	T5179	T5188	arg2Of	as,observed
R4080	T5181	T5179	arg2Of	increase,as
R4081	T5181	T5180	arg1Of	increase,an
R4082	T5181	T5182	arg1Of	increase,in
R4083	T5185	T5182	arg2Of	levels,in
R4084	T5185	T5183	arg1Of	levels,intracellular
R4085	T5185	T5184	arg1Of	levels,calcium
R4086	T5188	T5168	arg1Of	observed,Furthermore
R4087	T5188	T5169	arg1Of	observed,","
R4088	T5188	T5186	arg2Of	observed,was
R4089	T5188	T5187	arg1Of	observed,also
R4090	T5188	T5189	arg1Of	observed,following
R4091	T5191	T5189	arg2Of	stimulation,following
R4092	T5191	T5190	arg1Of	stimulation,BCR
R4093	T5191	T5192	arg1Of	stimulation,of
R4094	T5195	T5192	arg2Of	cells,of
R4095	T5195	T5193	arg1Of	cells,PKD1/3-null
R4096	T5195	T5194	arg1Of	cells,B
R4097	T5195	T5196	arg1Of	cells,(
R4098	T5197	T5196	arg2Of	data,(
R4099	T5197	T5199	arg2Of	data,shown
R4100	T5199	T5198	arg1Of	shown,not
R4101	T5200	T5196	arg3Of	),(
R4102	T5201	T5202	arg1Of	We,did
R4103	T5201	T5203	arg1Of	We,observe
R4104	T5203	T5202	arg2Of	observe,did
R4105	T5206	T5205	arg1Of	strength,the
R4106	T5206	T5207	arg1Of	strength,of
R4107	T5206	T5222	arg1Of	strength,was
R4108	T5206	T5223	arg2Of	strength,reduced
R4109	T5208	T5209	arg1Of	BCR,(
R4110	T5210	T5211	arg1Of	but,not
R4111	T5213	T5209	arg2Of	ester,(
R4112	T5213	T5210	arg1Of	ester,but
R4113	T5213	T5212	arg1Of	ester,phorbol
R4114	T5214	T5209	arg3Of	),(
R4115	T5216	T5207	arg2Of	regulation,of
R4116	T5216	T5208	arg1Of	regulation,BCR
R4117	T5216	T5215	arg1Of	regulation,-induced
R4118	T5216	T5217	arg1Of	regulation,of
R4119	T5221	T5217	arg2Of	pathway,of
R4120	T5221	T5218	arg1Of	pathway,the
R4121	T5221	T5219	arg1Of	pathway,Erk1-RSK1
R4122	T5221	T5220	arg1Of	pathway,signalling
R4123	T5223	T5203	arg2Of	reduced,observe
R4124	T5223	T5204	arg1Of	reduced,that
R4125	T5223	T5222	arg2Of	reduced,was
R4126	T5223	T5224	arg1Of	reduced,in
R4127	T5223	T5228	arg1Of	reduced,compared
R4128	T5227	T5224	arg2Of	cells,in
R4129	T5227	T5225	arg1Of	cells,PKD1/3−/−
R4130	T5227	T5226	arg1Of	cells,B
R4131	T5229	T5228	arg2Of	to,compared
R4132	T5232	T5229	arg2Of	cells,to
R4133	T5232	T5230	arg1Of	cells,wild-type
R4134	T5232	T5231	arg1Of	cells,B
R4135	T5232	T5233	arg1Of	cells,(
R4136	T5235	T5233	arg2Of	3B,(
R4137	T5235	T5234	arg1Of	3B,Fig.
R4138	T5236	T5233	arg3Of	),(
R4139	T5238	T5237	arg1Of	interpretation,One
R4140	T5238	T5239	arg1Of	interpretation,of
R4141	T5238	T5242	arg1Of	interpretation,is
R4142	T5241	T5239	arg2Of	data,of
R4143	T5241	T5240	arg1Of	data,this
R4144	T5245	T5244	arg1Of	enzymes,PKD
R4145	T5245	T5246	arg1Of	enzymes,may
R4146	T5245	T5247	arg1Of	enzymes,modulate
R4147	T5247	T5242	arg2Of	modulate,is
R4148	T5247	T5243	arg1Of	modulate,that
R4149	T5247	T5246	arg2Of	modulate,may
R4150	T5249	T5247	arg2Of	activation,modulate
R4151	T5249	T5248	arg1Of	activation,Erk
R4152	T5253	T5252	arg1Of	enzymes,PKD
R4153	T5253	T5254	arg1Of	enzymes,have
R4154	T5253	T5256	arg1Of	enzymes,been
R4155	T5253	T5257	arg2Of	enzymes,linked
R4156	T5257	T5250	arg1Of	linked,Indeed
R4157	T5257	T5251	arg1Of	linked,","
R4158	T5257	T5254	arg2Of	linked,have
R4159	T5257	T5255	arg1Of	linked,previously
R4160	T5257	T5256	arg2Of	linked,been
R4161	T5257	T5258	arg1Of	linked,to
R4162	T5257	T5264	arg1Of	linked,in
R4163	T5263	T5258	arg2Of	signalling,to
R4164	T5263	T5259	arg1Of	signalling,the
R4165	T5263	T5260	arg1Of	signalling,growth
R4166	T5263	T5261	arg1Of	signalling,factor-regulated
R4167	T5263	T5262	arg1Of	signalling,Erk
R4168	T5265	T5266	arg1Of	fibroblast,and
R4169	T5266	T5264	arg2Of	and,in
R4170	T5269	T5266	arg2Of	lines,and
R4171	T5269	T5267	arg1Of	lines,endothelial
R4172	T5269	T5268	arg1Of	lines,cell
R4173	T5269	T5270	arg1Of	lines,[
R4174	T5271	T5270	arg2Of	33–35,[
R4175	T5272	T5270	arg3Of	],[
R4176	T5277	T5275	arg1Of	phosphorylation,BCR-induced
R4177	T5277	T5276	arg1Of	phosphorylation,Erk
R4178	T5277	T5278	arg1Of	phosphorylation,was
R4179	T5277	T5280	arg2Of	phosphorylation,reduced
R4180	T5280	T5273	arg1Of	reduced,However
R4181	T5280	T5274	arg1Of	reduced,","
R4182	T5280	T5278	arg2Of	reduced,was
R4183	T5280	T5279	arg1Of	reduced,also
R4184	T5280	T5281	arg1Of	reduced,in
R4185	T5280	T5290	modOf	reduced,suggesting
R4186	T5284	T5281	arg2Of	cells,in
R4187	T5284	T5282	arg1Of	cells,PKD1/3−/−-Flag-PKD3+
R4188	T5284	T5283	arg1Of	cells,B
R4189	T5284	T5285	arg1Of	cells,(
R4190	T5286	T5285	arg2Of	data,(
R4191	T5286	T5288	arg2Of	data,shown
R4192	T5288	T5287	arg1Of	shown,not
R4193	T5289	T5285	arg3Of	),(
R4194	T5294	T5292	arg2Of	levels,reduced
R4195	T5294	T5293	arg1Of	levels,BCR
R4196	T5294	T5295	arg1Of	levels,on
R4197	T5294	T5306	arg1Of	levels,may
R4198	T5294	T5308	arg1Of	levels,impact
R4199	T5297	T5295	arg2Of	surface,on
R4200	T5297	T5296	arg1Of	surface,the
R4201	T5297	T5298	arg1Of	surface,of
R4202	T5299	T5300	arg1Of	PKD1/3−/−,(
R4203	T5302	T5300	arg2Of	PKD1/3−/−-Flag-PKD3+,(
R4204	T5302	T5301	arg1Of	PKD1/3−/−-Flag-PKD3+,and
R4205	T5303	T5300	arg3Of	),(
R4206	T5305	T5298	arg2Of	cells,of
R4207	T5305	T5299	arg1Of	cells,PKD1/3−/−
R4208	T5305	T5304	arg1Of	cells,B
R4209	T5308	T5290	arg2Of	impact,suggesting
R4210	T5308	T5291	arg1Of	impact,that
R4211	T5308	T5306	arg2Of	impact,may
R4212	T5308	T5307	arg1Of	impact,itself
R4213	T5308	T5309	arg1Of	impact,on
R4214	T5311	T5309	arg2Of	strength,on
R4215	T5311	T5310	arg1Of	strength,the
R4216	T5311	T5312	arg1Of	strength,of
R4217	T5313	T5312	arg2Of	activation,of
R4218	T5313	T5314	arg1Of	activation,of
R4219	T5319	T5314	arg2Of	pathway,of
R4220	T5319	T5315	arg1Of	pathway,this
R4221	T5319	T5316	arg1Of	pathway,specific
R4222	T5319	T5317	arg1Of	pathway,intracellular
R4223	T5319	T5318	arg1Of	pathway,signalling
R4224	T5321	T5320	arg1Of	search,To
R4225	T5321	T5322	arg1Of	search,for
R4226	T5326	T5322	arg2Of	targets,for
R4227	T5326	T5323	arg1Of	targets,other
R4228	T5326	T5324	arg1Of	targets,potential
R4229	T5326	T5325	arg1Of	targets,PKD
R4230	T5326	T5327	arg1Of	targets,that
R4231	T5326	T5328	arg1Of	targets,may
R4232	T5326	T5329	arg1Of	targets,show
R4233	T5329	T5328	arg2Of	show,may
R4234	T5329	T5332	arg1Of	show,in
R4235	T5331	T5329	arg2Of	regulation,show
R4236	T5331	T5330	arg1Of	regulation,defective
R4237	T5336	T5332	arg2Of	cells,in
R4238	T5336	T5333	arg1Of	cells,PKD1/3−/−
R4239	T5336	T5334	arg1Of	cells,DT40
R4240	T5336	T5335	arg1Of	cells,B
R4241	T5338	T5321	arg1Of	we,search
R4242	T5338	T5339	arg1Of	we,used
R4243	T5339	T5320	modOf	used,To
R4244	T5339	T5337	arg1Of	used,","
R4245	T5343	T5339	arg2Of	phospho-antibody,used
R4246	T5343	T5340	arg1Of	phospho-antibody,a
R4247	T5343	T5341	arg1Of	phospho-antibody,PKD
R4248	T5343	T5342	arg1Of	phospho-antibody,substrate
R4249	T5343	T5344	arg1Of	phospho-antibody,that
R4250	T5343	T5345	arg1Of	phospho-antibody,recognises
R4251	T5348	T5345	arg2Of	sequences,recognises
R4252	T5348	T5346	arg1Of	sequences,consensus
R4253	T5348	T5347	arg1Of	sequences,phosphorylation
R4254	T5348	T5349	arg2Of	sequences,targeted
R4255	T5349	T5356	arg1Of	targeted,[
R4256	T5352	T5349	arg1Of	enzymes,targeted
R4257	T5352	T5350	arg2Of	enzymes,by
R4258	T5352	T5351	arg1Of	enzymes,PKD
R4259	T5352	T5353	arg1Of	enzymes,(
R4260	T5354	T5353	arg2Of	LxRxxpS/T,(
R4261	T5355	T5353	arg3Of	),(
R4262	T5357	T5356	arg2Of	36,[
R4263	T5358	T5356	arg3Of	],[
R4264	T5360	T5359	arg2Of	shown,As
R4265	T5360	T5361	arg1Of	shown,in
R4266	T5363	T5361	arg2Of	3C,in
R4267	T5363	T5362	arg1Of	3C,Fig.
R4268	T5366	T5365	arg1Of	ester-,phorbol
R4269	T5366	T5367	arg1Of	ester-,and
R4270	T5368	T5367	arg2Of	BCR-induced,and
R4271	T5369	T5366	arg1Of	phosphorylation,ester-
R4272	T5369	T5368	arg1Of	phosphorylation,BCR-induced
R4273	T5369	T5370	arg1Of	phosphorylation,of
R4274	T5369	T5377	arg1Of	phosphorylation,was
R4275	T5369	T5378	arg1Of	phosphorylation,similar
R4276	T5369	T5385	arg1Of	phosphorylation,is
R4277	T5369	T5387	arg1Of	phosphorylation,independent
R4278	T5372	T5370	arg2Of	substrates,of
R4279	T5372	T5371	arg1Of	substrates,cellular
R4280	T5372	T5373	arg2Of	substrates,detected
R4281	T5376	T5373	arg1Of	phospho-antibody,detected
R4282	T5376	T5374	arg2Of	phospho-antibody,by
R4283	T5376	T5375	arg1Of	phospho-antibody,this
R4284	T5377	T5384	arg1Of	was,and
R4285	T5378	T5377	arg2Of	similar,was
R4286	T5378	T5379	arg1Of	similar,in
R4287	T5380	T5381	arg1Of	wild-type,and
R4288	T5381	T5379	arg2Of	and,in
R4289	T5383	T5381	arg2Of	cells,and
R4290	T5383	T5382	arg1Of	cells,PKD1/3−/−
R4291	T5384	T5359	arg1Of	and,As
R4292	T5384	T5364	arg1Of	and,","
R4293	T5385	T5384	arg2Of	is,and
R4294	T5385	T5386	arg1Of	is,therefore
R4295	T5387	T5385	arg2Of	independent,is
R4296	T5387	T5388	arg1Of	independent,of
R4297	T5390	T5388	arg2Of	enzymes,of
R4298	T5390	T5389	arg1Of	enzymes,PKD
R4299	T5393	T5394	arg1Of	pretreatment,of
R4300	T5393	T5402	arg1Of	pretreatment,with
R4301	T5393	T5411	arg1Of	pretreatment,prevented
R4302	T5401	T5394	arg2Of	cells,of
R4303	T5401	T5395	arg1Of	cells,both
R4304	T5401	T5396	arg1Of	cells,wild-type
R4305	T5401	T5397	arg1Of	cells,and
R4306	T5401	T5398	arg1Of	cells,PKD1/3−/−
R4307	T5401	T5399	arg1Of	cells,DT40
R4308	T5401	T5400	arg1Of	cells,B
R4309	T5403	T5402	arg2Of	GF109203X,with
R4310	T5403	T5404	arg1Of	GF109203X,","
R4311	T5407	T5404	arg2Of	derivative,","
R4312	T5407	T5405	arg1Of	derivative,a
R4313	T5407	T5406	arg1Of	derivative,bisindoylmaleimide
R4314	T5407	T5408	arg1Of	derivative,that
R4315	T5407	T5409	arg1Of	derivative,inhibits
R4316	T5410	T5409	arg2Of	PKCs,inhibits
R4317	T5411	T5391	arg1Of	prevented,However
R4318	T5411	T5392	arg1Of	prevented,","
R4319	T5413	T5411	arg2Of	induction,prevented
R4320	T5413	T5412	arg1Of	induction,the
R4321	T5413	T5414	arg1Of	induction,of
R4322	T5415	T5414	arg2Of	proteins,of
R4323	T5415	T5416	arg1Of	proteins,that
R4324	T5415	T5417	arg1Of	proteins,contain
R4325	T5420	T5417	arg2Of	motifs,contain
R4326	T5420	T5418	arg2Of	motifs,phosphorylated
R4327	T5420	T5419	arg1Of	motifs,LxRxxS/T
R4328	T5422	T5423	arg1Of	loss,of
R4329	T5422	T5426	arg1Of	loss,does
R4330	T5422	T5429	arg1Of	loss,disrupt
R4331	T5425	T5423	arg2Of	enzymes,of
R4332	T5425	T5424	arg1Of	enzymes,PKD1/3
R4333	T5429	T5421	arg1Of	disrupt,Thus
R4334	T5429	T5426	arg2Of	disrupt,does
R4335	T5429	T5427	arg1Of	disrupt,not
R4336	T5429	T5428	arg1Of	disrupt,globally
R4337	T5431	T5429	arg2Of	phosphorylation,disrupt
R4338	T5431	T5430	arg1Of	phosphorylation,the
R4339	T5431	T5432	arg1Of	phosphorylation,of
R4340	T5434	T5432	arg2Of	proteins,of
R4341	T5434	T5433	arg1Of	proteins,cellular
R4342	T5434	T5435	arg1Of	proteins,that
R4343	T5434	T5436	arg1Of	proteins,contain
R4344	T5438	T5436	arg2Of	motifs,contain
R4345	T5438	T5437	arg1Of	motifs,LxRxxpS/T
R4346	T5440	T5439	arg1Of	result,This
R4347	T5440	T5441	arg1Of	result,is
R4348	T5440	T5444	arg1Of	result,surprising
R4349	T5441	T5443	arg1Of	is,not
R4350	T5441	T5445	arg1Of	is,as
R4351	T5443	T5442	arg1Of	not,perhaps
R4352	T5444	T5441	arg2Of	surprising,is
R4353	T5447	T5446	arg1Of	motifs,LxRxxS/T
R4354	T5447	T5449	arg1Of	motifs,act
R4355	T5449	T5445	arg2Of	act,as
R4356	T5449	T5448	arg1Of	act,also
R4357	T5449	T5450	arg1Of	act,as
R4358	T5452	T5450	arg2Of	substrates,as
R4359	T5452	T5451	arg1Of	substrates,good
R4360	T5452	T5453	arg1Of	substrates,for
R4361	T5456	T5453	arg2Of	kinases,for
R4362	T5456	T5454	arg1Of	kinases,other
R4363	T5456	T5455	arg1Of	kinases,serine/threonine
R4364	T5456	T5458	arg1Of	kinases,as
R4365	T5458	T5457	arg1Of	as,such
R4366	T5459	T5458	arg2Of	MAPKAPK2,as
R4367	T5462	T5461	arg1Of	experiments,these
R4368	T5462	T5463	arg1Of	experiments,do
R4369	T5462	T5464	arg1Of	experiments,provide
R4370	T5464	T5460	arg1Of	provide,However
R4371	T5464	T5463	arg2Of	provide,do
R4372	T5466	T5464	arg2Of	evidence,provide
R4373	T5466	T5465	arg1Of	evidence,further
R4374	T5469	T5468	arg1Of	antisera,phosphospecific
R4375	T5469	T5470	arg1Of	antisera,are
R4376	T5469	T5473	arg1Of	antisera,selective
R4377	T5470	T5466	arg2Of	are,evidence
R4378	T5470	T5467	arg1Of	are,that
R4379	T5470	T5471	arg1Of	are,not
R4380	T5473	T5470	arg2Of	selective,are
R4381	T5473	T5472	arg1Of	selective,sufficiently
R4382	T5473	T5474	modOf	selective,to
R4383	T5476	T5474	arg1Of	designated,to
R4384	T5476	T5475	arg2Of	designated,be
R4385	T5478	T5477	arg1Of	specific,kinase
R4386	T5480	T5476	arg3Of	antisera,designated
R4387	T5480	T5478	arg1Of	antisera,specific
R4388	T5480	T5479	arg1Of	antisera,substrate
R4389	T5483	T5481	arg1Of	pathways,BCR-induced
R4390	T5483	T5482	arg1Of	pathways,signalling
R4391	T5483	T5484	arg1Of	pathways,culminate
R4392	T5484	T5485	arg1Of	culminate,in
R4393	T5487	T5485	arg2Of	activation,in
R4394	T5487	T5486	arg1Of	activation,the
R4395	T5487	T5488	arg1Of	activation,of
R4396	T5491	T5488	arg2Of	events,of
R4397	T5491	T5489	arg1Of	events,gene
R4398	T5491	T5490	arg1Of	events,transcription
R4399	T5491	T5492	arg1Of	events,that
R4400	T5491	T5493	arg1Of	events,control
R4401	T5496	T5497	arg1Of	survival,","
R4402	T5497	T5499	arg1Of	",",and
R4403	T5498	T5497	arg2Of	proliferation,","
R4404	T5499	T5493	arg2Of	and,control
R4405	T5499	T5494	arg1Of	and,B
R4406	T5499	T5495	arg1Of	and,cell
R4407	T5500	T5499	arg2Of	function,and
R4408	T5503	T5501	arg2Of	context,In
R4409	T5503	T5502	arg1Of	context,this
R4410	T5508	T5501	arg1Of	proposed,In
R4411	T5508	T5504	arg1Of	proposed,","
R4412	T5508	T5506	arg2Of	proposed,has
R4413	T5508	T5507	arg2Of	proposed,been
R4414	T5508	T5517	arg1Of	proposed,through
R4415	T5513	T5505	arg1Of	control,it
R4416	T5513	T5506	arg1Of	control,has
R4417	T5513	T5507	arg1Of	control,been
R4418	T5513	T5508	arg2Of	control,proposed
R4419	T5513	T5509	arg1Of	control,that
R4420	T5513	T5510	arg1Of	control,PKD
R4421	T5513	T5511	arg1Of	control,family
R4422	T5513	T5512	arg1Of	control,members
R4423	T5513	T5514	arg1Of	control,of
R4424	T5516	T5514	arg2Of	transcription,of
R4425	T5516	T5515	arg1Of	transcription,gene
R4426	T5518	T5517	arg2Of	activation,through
R4427	T5518	T5519	arg1Of	activation,of
R4428	T5523	T5519	arg2Of	factor,of
R4429	T5523	T5520	arg1Of	factor,the
R4430	T5523	T5521	arg1Of	factor,NFκB
R4431	T5523	T5522	arg1Of	factor,transcription
R4432	T5527	T5526	arg1Of	activation,PKD-mediated
R4433	T5527	T5528	arg1Of	activation,of
R4434	T5527	T5530	arg1Of	activation,occurs
R4435	T5529	T5528	arg2Of	NFκB,of
R4436	T5530	T5524	arg1Of	occurs,Thus
R4437	T5530	T5525	arg1Of	occurs,","
R4438	T5530	T5531	arg1Of	occurs,downstream
R4439	T5531	T5532	arg1Of	downstream,of
R4440	T5534	T5532	arg2Of	variety,of
R4441	T5534	T5533	arg1Of	variety,a
R4442	T5534	T5535	arg1Of	variety,of
R4443	T5537	T5535	arg2Of	signals,of
R4444	T5537	T5536	arg1Of	signals,different
R4445	T5537	T5538	arg1Of	signals,","
R4446	T5537	T5539	arg1Of	signals,including
R4447	T5541	T5540	arg1Of	stress,mROS/oxidative
R4448	T5541	T5542	arg1Of	stress,","
R4449	T5542	T5545	arg1Of	",",and
R4450	T5544	T5542	arg2Of	acid,","
R4451	T5544	T5543	arg1Of	acid,lysophosphatidic
R4452	T5545	T5539	arg2Of	and,including
R4453	T5547	T5546	arg1Of	Bcr-Abl,the
R4454	T5548	T5545	arg2Of	oncogene,and
R4455	T5548	T5547	arg1Of	oncogene,Bcr-Abl
R4456	T5548	T5549	arg1Of	oncogene,[
R4457	T5550	T5549	arg2Of	"17,21,23,30,37",[
R4458	T5551	T5549	arg3Of	],[
R4459	T5554	T5555	arg1Of	expression,of
R4460	T5554	T5560	arg1Of	expression,enhances
R4461	T5559	T5555	arg2Of	mutant,of
R4462	T5559	T5556	arg1Of	mutant,an
R4463	T5559	T5557	arg2Of	mutant,activated
R4464	T5559	T5558	arg1Of	mutant,PKD1
R4465	T5560	T5552	arg1Of	enhances,Furthermore
R4466	T5560	T5553	arg1Of	enhances,","
R4467	T5560	T5564	arg1Of	enhances,[
R4468	T5563	T5560	arg2Of	activation,enhances
R4469	T5563	T5561	arg1Of	activation,HPK1-mediated
R4470	T5563	T5562	arg1Of	activation,NFκB
R4471	T5565	T5564	arg2Of	38,[
R4472	T5566	T5564	arg3Of	],[
R4473	T5569	T5567	arg2Of	cells,In
R4474	T5569	T5568	arg1Of	cells,B
R4475	T5571	T5572	arg1Of	NFκB,is
R4476	T5571	T5573	arg2Of	NFκB,known
R4477	T5571	T5575	arg1Of	NFκB,be
R4478	T5571	T5576	arg2Of	NFκB,regulated
R4479	T5573	T5572	arg2Of	known,is
R4480	T5573	T5584	arg1Of	known,but
R4481	T5576	T5573	arg3Of	regulated,known
R4482	T5576	T5574	arg1Of	regulated,to
R4483	T5576	T5575	arg2Of	regulated,be
R4484	T5576	T5577	arg1Of	regulated,via
R4485	T5576	T5581	arg1Of	regulated,[
R4486	T5578	T5579	arg1Of	DAG,and
R4487	T5579	T5577	arg2Of	and,via
R4488	T5580	T5579	arg2Of	PKCβ,and
R4489	T5582	T5581	arg2Of	"39,40",[
R4490	T5583	T5581	arg3Of	],[
R4491	T5584	T5567	arg1Of	but,In
R4492	T5584	T5570	arg1Of	but,","
R4493	T5586	T5587	arg1Of	PKDs,are
R4494	T5587	T5585	arg1Of	are,whether
R4495	T5587	T5593	arg1Of	are,has
R4496	T5587	T5595	arg1Of	are,been
R4497	T5587	T5596	arg2Of	are,explored
R4498	T5589	T5587	arg2Of	intermediaries,are
R4499	T5589	T5588	arg1Of	intermediaries,key
R4500	T5589	T5590	arg1Of	intermediaries,for
R4501	T5592	T5590	arg2Of	regulation,for
R4502	T5592	T5591	arg1Of	regulation,NFκB
R4503	T5596	T5584	arg2Of	explored,but
R4504	T5596	T5593	arg2Of	explored,has
R4505	T5596	T5594	arg1Of	explored,not
R4506	T5596	T5595	arg2Of	explored,been
R4507	T5598	T5597	arg1Of	data,The
R4508	T5598	T5599	arg1Of	data,(
R4509	T5598	T5603	arg1Of	data,show
R4510	T5601	T5599	arg2Of	4A,(
R4511	T5601	T5600	arg1Of	4A,Fig.
R4512	T5602	T5599	arg3Of	),(
R4513	T5607	T5605	arg1Of	activity,NFκB
R4514	T5607	T5606	arg1Of	activity,transcriptional
R4515	T5607	T5608	arg1Of	activity,was
R4516	T5607	T5610	arg2Of	activity,induced
R4517	T5610	T5603	arg2Of	induced,show
R4518	T5610	T5604	arg1Of	induced,that
R4519	T5610	T5608	arg2Of	induced,was
R4520	T5610	T5609	arg1Of	induced,strongly
R4521	T5610	T5611	arg1Of	induced,in
R4522	T5610	T5619	arg1Of	induced,in
R4523	T5618	T5611	arg2Of	cells,in
R4524	T5618	T5612	arg1Of	cells,both
R4525	T5618	T5613	arg1Of	cells,wild-type
R4526	T5618	T5614	arg1Of	cells,and
R4527	T5618	T5615	arg1Of	cells,PKD1/3−/−
R4528	T5618	T5616	arg1Of	cells,DT40
R4529	T5618	T5617	arg1Of	cells,B
R4530	T5620	T5619	arg2Of	response,in
R4531	T5620	T5621	arg1Of	response,to
R4532	T5624	T5623	arg1Of	ester,phorbol
R4533	T5624	T5625	arg1Of	ester,or
R4534	T5625	T5621	arg2Of	or,to
R4535	T5625	T5622	arg1Of	or,either
R4536	T5627	T5625	arg2Of	stimulation,or
R4537	T5627	T5626	arg1Of	stimulation,BCR
R4538	T5629	T5628	arg2Of	contrast,In
R4539	T5631	T5666	arg1Of	BCR,was
R4540	T5631	T5667	arg2Of	BCR,observed
R4541	T5634	T5632	arg1Of	ester-induced,and
R4542	T5634	T5633	arg1Of	ester-induced,phorbol
R4543	T5637	T5634	arg1Of	activity,ester-induced
R4544	T5637	T5635	arg1Of	activity,NFκB
R4545	T5637	T5636	arg1Of	activity,transcriptional
R4546	T5637	T5638	arg1Of	activity,was
R4547	T5637	T5639	arg2Of	activity,abolished
R4548	T5639	T5638	arg2Of	abolished,was
R4549	T5639	T5640	arg1Of	abolished,in
R4550	T5639	T5649	arg1Of	abolished,","
R4551	T5639	T5650	arg1Of	abolished,although
R4552	T5639	T5656	arg1Of	abolished,(
R4553	T5644	T5640	arg2Of	cells,in
R4554	T5644	T5641	arg1Of	cells,PKCβ−/−
R4555	T5644	T5642	arg1Of	cells,DT40
R4556	T5644	T5643	arg1Of	cells,B
R4557	T5644	T5645	arg1Of	cells,(
R4558	T5647	T5645	arg2Of	4A,(
R4559	T5647	T5646	arg1Of	4A,Fig.
R4560	T5648	T5645	arg3Of	),(
R4561	T5652	T5650	arg2Of	activation,although
R4562	T5652	T5651	arg1Of	activation,strong
R4563	T5652	T5653	arg1Of	activation,of
R4564	T5655	T5653	arg2Of	kinases,of
R4565	T5655	T5654	arg1Of	kinases,PKD
R4566	T5657	T5656	arg2Of	as,(
R4567	T5658	T5657	arg2Of	assessed,as
R4568	T5658	T5659	arg1Of	assessed,by
R4569	T5660	T5659	arg2Of	autophosphorylation,by
R4570	T5660	T5661	arg1Of	autophosphorylation,of
R4571	T5660	T5663	arg1Of	autophosphorylation,at
R4572	T5662	T5661	arg2Of	PKD1,of
R4573	T5664	T5663	arg2Of	S916,at
R4574	T5665	T5656	arg3Of	),(
R4575	T5667	T5628	arg1Of	observed,In
R4576	T5667	T5630	arg1Of	observed,","
R4577	T5667	T5638	modOf	observed,was
R4578	T5667	T5666	arg2Of	observed,was
R4579	T5667	T5668	arg1Of	observed,in
R4580	T5671	T5668	arg2Of	cells,in
R4581	T5671	T5669	arg1Of	cells,the
R4582	T5671	T5670	arg1Of	cells,PKCβ−/−
R4583	T5671	T5672	arg1Of	cells,(
R4584	T5674	T5672	arg2Of	4B,(
R4585	T5674	T5673	arg1Of	4B,Fig.
R4586	T5675	T5672	arg3Of	),(
R4587	T5679	T5678	arg1Of	kinases,PKD
R4588	T5679	T5680	arg1Of	kinases,are
R4589	T5679	T5682	arg1Of	kinases,essential
R4590	T5679	T5684	arg1Of	kinases,sufficient
R4591	T5679	T5686	arg1Of	kinases,mediate
R4592	T5679	T5696	arg1Of	kinases,do
R4593	T5679	T5698	arg1Of	kinases,participate
R4594	T5680	T5694	arg1Of	are,and
R4595	T5682	T5683	arg1Of	essential,nor
R4596	T5683	T5680	arg2Of	nor,are
R4597	T5683	T5681	arg1Of	nor,neither
R4598	T5684	T5683	arg2Of	sufficient,nor
R4599	T5686	T5682	arg2Of	mediate,essential
R4600	T5686	T5684	arg2Of	mediate,sufficient
R4601	T5686	T5685	arg1Of	mediate,to
R4602	T5689	T5686	arg2Of	activation,mediate
R4603	T5689	T5687	arg1Of	activation,BCR-induced
R4604	T5689	T5688	arg1Of	activation,NFκB
R4605	T5689	T5690	arg1Of	activation,in
R4606	T5693	T5690	arg2Of	cells,in
R4607	T5693	T5691	arg1Of	cells,DT40
R4608	T5693	T5692	arg1Of	cells,B
R4609	T5694	T5676	arg1Of	and,Thus
R4610	T5694	T5677	arg1Of	and,","
R4611	T5698	T5694	arg2Of	participate,and
R4612	T5698	T5695	arg1Of	participate,hence
R4613	T5698	T5696	arg2Of	participate,do
R4614	T5698	T5697	arg1Of	participate,not
R4615	T5698	T5699	arg1Of	participate,in
R4616	T5702	T5699	arg2Of	control,in
R4617	T5702	T5700	arg1Of	control,DAG/PKC
R4618	T5702	T5701	arg2Of	control,mediated
R4619	T5702	T5703	arg1Of	control,of
R4620	T5704	T5703	arg2Of	NFκB,of

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T2673	125-141	Anaphor	denotes	two PKD isoforms
T2674	143-147	Antecedent	denotes	PKD1
T2675	152-156	Antecedent	denotes	PKD3
R2277	T2673	T2674	boundBy	two PKD isoforms,PKD1
R2278	T2673	T2675	boundBy	two PKD isoforms,PKD3

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T2731	17-21	NN	denotes	Loss
T2732	22-24	IN	denotes	of
T2733	25-30	NNP	denotes	HSP27
T2734	31-46	NN	denotes	phosphorylation
T2735	47-49	IN	denotes	in
T2736	50-54	NNP	denotes	DT40
T2737	55-56	NNP	denotes	B
T2738	57-62	NNS	denotes	cells
T2739	63-70	VBG	denotes	lacking
T2740	71-81	NN	denotes	expression
T2741	82-84	IN	denotes	of
T2742	85-88	NNP	denotes	PKD
T2743	89-95	NN	denotes	family
T2744	96-103	VBZ	denotes	kinases
T2745	104-108	NNP	denotes	DT40
T2746	109-110	NNP	denotes	B
T2747	111-116	NNS	denotes	cells
T2748	117-124	VBP	denotes	express
T2749	125-128	CD	denotes	two
T2750	129-132	NNP	denotes	PKD
T2751	133-141	NNS	denotes	isoforms
T2752	141-142	,	denotes	,
T2753	143-147	NNP	denotes	PKD1
T2754	148-151	CC	denotes	and
T2755	152-156	NNP	denotes	PKD3
T2756	156-157	,	denotes	,
T2757	158-161	CC	denotes	and
T2758	162-164	IN	denotes	as
T2759	165-175	RB	denotes	previously
T2760	176-185	VBN	denotes	described
T2761	186-188	PRP	denotes	we
T2762	189-193	VBP	denotes	have
T2763	194-202	RB	denotes	recently
T2764	203-212	VBN	denotes	generated
T2765	213-217	NNP	denotes	DT40
T2766	218-219	NNP	denotes	B
T2767	220-224	NN	denotes	cell
T2768	225-230	NNS	denotes	lines
T2769	231-235	WDT	denotes	that
T2770	236-240	VBP	denotes	lack
T2771	241-251	NN	denotes	expression
T2772	252-254	IN	denotes	of
T2773	255-261	DT	denotes	either
T2774	262-266	CD	denotes	PKD1
T2775	267-269	CC	denotes	or
T2776	270-274	CD	denotes	PKD3
T2777	275-277	CC	denotes	or
T2778	278-282	DT	denotes	both
T2779	283-290	NNS	denotes	enzymes
T2780	291-292	VBP	denotes	[
T2781	292-293	CD	denotes	1
T2782	293-294	NNP	denotes	]
T2783	294-295	.	denotes	.
T2784	296-298	IN	denotes	In
T2785	299-309	VBG	denotes	generating
T2786	310-313	DT	denotes	the
T2787	314-320	JJ	denotes	double
T2788	321-329	NN	denotes	knockout
T2789	330-334	NN	denotes	cell
T2790	335-340	NNS	denotes	lines
T2791	341-343	PRP	denotes	we
T2792	344-352	VBD	denotes	targeted
T2793	353-356	DT	denotes	the
T2794	357-361	NNP	denotes	PKD1
T2795	362-366	NN	denotes	loci
T2796	367-369	IN	denotes	in
T2797	370-371	DT	denotes	a
T2798	372-376	NNP	denotes	PKD3
T2799	376-377	NNP	denotes	−
T2800	377-378	VBD	denotes	/
T2801	378-379	CD	denotes	−
T2802	380-384	NN	denotes	cell
T2803	385-389	NN	denotes	line
T2804	390-394	WDT	denotes	that
T2805	395-404	VBD	denotes	expressed
T2806	405-406	DT	denotes	a
T2807	407-416	NN	denotes	Flag-PKD3
T2808	417-426	NN	denotes	transgene
T2809	427-432	IN	denotes	under
T2810	433-436	DT	denotes	the
T2811	437-444	NN	denotes	control
T2812	445-447	IN	denotes	of
T2813	448-449	DT	denotes	a
T2814	450-471	JJ	denotes	doxycycline-inducible
T2815	472-480	NN	denotes	promoter
T2816	480-481	.	denotes	.
T2817	482-487	RB	denotes	Hence
T2818	487-488	,	denotes	,
T2819	489-491	IN	denotes	in
T2820	492-495	DT	denotes	the
T2821	496-504	NN	denotes	presence
T2822	505-507	IN	denotes	of
T2823	508-519	NN	denotes	doxycycline
T2824	519-520	,	denotes	,
T2825	521-530	NN	denotes	Flag-PKD3
T2826	531-541	NN	denotes	expression
T2827	542-544	IN	denotes	in
T2828	545-551	CD	denotes	PKD1/3
T2829	552-558	JJ	denotes	double
T2830	559-567	NN	denotes	knockout
T2831	568-573	NNS	denotes	cells
T2832	574-576	VBZ	denotes	is
T2833	577-587	JJ	denotes	comparable
T2834	588-590	TO	denotes	to
T2835	591-601	JJ	denotes	endogenous
T2836	602-606	JJ	denotes	PKD3
T2837	607-614	NN	denotes	present
T2838	615-617	IN	denotes	in
T2839	618-627	JJ	denotes	wild-type
T2840	628-632	NNP	denotes	DT40
T2841	633-638	NNS	denotes	cells
T2842	639-642	CC	denotes	and
T2843	643-650	NN	denotes	removal
T2844	651-653	IN	denotes	of
T2845	654-665	NN	denotes	doxycycline
T2846	666-670	IN	denotes	from
T2847	671-674	DT	denotes	the
T2848	675-682	NN	denotes	culture
T2849	683-688	NNS	denotes	media
T2850	689-692	IN	denotes	for
T2851	693-694	CD	denotes	5
T2852	695-699	NNS	denotes	days
T2853	700-707	NNS	denotes	results
T2854	708-710	IN	denotes	in
T2855	711-712	DT	denotes	a
T2856	713-723	RB	denotes	completely
T2857	724-728	JJ	denotes	null
T2858	729-732	NNP	denotes	PKD
T2859	733-742	NN	denotes	phenotype
T2860	743-744	-LRB-	denotes	(
T2861	744-748	NNP	denotes	Fig.
T2862	749-751	NNP	denotes	1A
T2863	751-752	-RRB-	denotes	)
T2864	752-753	.	denotes	.
T2865	754-764	RB	denotes	Previously
T2866	764-765	,	denotes	,
T2867	766-768	PRP	denotes	we
T2868	769-773	VBP	denotes	have
T2869	774-786	VBN	denotes	demonstrated
T2870	787-791	IN	denotes	that
T2871	792-807	NN	denotes	phosphorylation
T2872	808-811	CC	denotes	and
T2873	812-819	JJ	denotes	nuclear
T2874	820-829	NN	denotes	exclusion
T2875	830-832	IN	denotes	of
T2876	833-838	NN	denotes	class
T2877	839-841	NNP	denotes	II
T2878	842-849	NN	denotes	histone
T2879	850-862	NNS	denotes	deacetylases
T2880	863-864	-LRB-	denotes	(
T2881	864-869	NNS	denotes	HDACs
T2882	869-870	-RRB-	denotes	)
T2883	871-877	IN	denotes	during
T2884	878-881	NNP	denotes	BCR
T2885	882-892	NN	denotes	engagement
T2886	893-895	VBZ	denotes	is
T2887	896-905	JJ	denotes	defective
T2888	906-908	IN	denotes	in
T2889	909-915	CD	denotes	PKD1/3
T2890	915-916	CD	denotes	−
T2891	916-917	NN	denotes	/
T2892	917-918	NN	denotes	−
T2893	919-920	NNP	denotes	B
T2894	921-926	NNS	denotes	cells
T2895	927-930	CC	denotes	and
T2896	931-934	MD	denotes	can
T2897	935-943	VBD	denotes	restored
T2898	944-948	IN	denotes	upon
T2899	949-962	NN	denotes	re-expression
T2900	963-965	IN	denotes	of
T2901	966-967	DT	denotes	a
T2902	968-974	JJ	denotes	single
T2903	975-978	NNP	denotes	PKD
T2904	979-986	NN	denotes	isoform
T2905	987-988	NNP	denotes	[
T2906	988-989	CD	denotes	1
T2907	989-990	NNP	denotes	]
T2908	990-991	.	denotes	.
T2909	992-995	DT	denotes	The
T2910	996-1001	JJ	denotes	small
T2911	1002-1006	NN	denotes	heat
T2912	1007-1012	NN	denotes	shock
T2913	1013-1020	NN	denotes	protein
T2914	1021-1026	NNP	denotes	HSP27
T2915	1027-1030	VBZ	denotes	has
T2916	1031-1039	RB	denotes	recently
T2917	1040-1044	VBN	denotes	been
T2918	1045-1053	VBN	denotes	proposed
T2919	1054-1056	IN	denotes	as
T2920	1057-1058	DT	denotes	a
T2921	1059-1063	NNP	denotes	PKD1
T2922	1064-1073	VB	denotes	substrate
T2923	1074-1075	NNP	denotes	[
T2924	1075-1077	CD	denotes	24
T2925	1077-1078	NNP	denotes	]
T2926	1079-1082	CC	denotes	and
T2927	1083-1085	PRP	denotes	we
T2928	1086-1097	RB	denotes	accordingly
T2929	1098-1106	VBD	denotes	assessed
T2930	1107-1114	IN	denotes	whether
T2931	1115-1123	NNP	denotes	PKD-null
T2932	1124-1128	NNP	denotes	DT40
T2933	1129-1134	NNS	denotes	cells
T2934	1135-1139	VBP	denotes	have
T2935	1140-1149	JJ	denotes	defective
T2936	1150-1165	NN	denotes	phosphorylation
T2937	1166-1168	IN	denotes	of
T2938	1169-1174	NNP	denotes	HSP27
T2939	1175-1177	IN	denotes	on
T2940	1178-1184	NN	denotes	serine
T2941	1185-1187	CD	denotes	82
T2942	1187-1188	,	denotes	,
T2943	1189-1192	DT	denotes	the
T2944	1193-1201	VBN	denotes	proposed
T2945	1202-1206	NNP	denotes	PKD1
T2946	1207-1216	VB	denotes	substrate
T2947	1217-1225	NN	denotes	sequence
T2948	1225-1226	.	denotes	.
T2949	1227-1229	PRP	denotes	We
T2950	1230-1239	RB	denotes	initially
T2951	1240-1252	VBD	denotes	investigated
T2952	1253-1256	DT	denotes	the
T2953	1257-1267	NN	denotes	regulation
T2954	1268-1270	IN	denotes	of
T2955	1271-1276	NNP	denotes	HSP27
T2956	1277-1292	NN	denotes	phosphorylation
T2957	1293-1295	IN	denotes	in
T2958	1296-1302	JJ	denotes	single
T2959	1303-1311	NN	denotes	knockout
T2960	1312-1316	NNP	denotes	DT40
T2961	1317-1318	NNP	denotes	B
T2962	1319-1324	NNS	denotes	cells
T2963	1325-1332	VBG	denotes	lacking
T2964	1333-1339	CC	denotes	either
T2965	1340-1344	CD	denotes	PKD1
T2966	1345-1347	CC	denotes	or
T2967	1348-1352	CD	denotes	PKD3
T2968	1352-1353	.	denotes	.
T2969	1354-1356	IN	denotes	As
T2970	1357-1362	VBN	denotes	shown
T2971	1363-1365	IN	denotes	in
T2972	1366-1370	NNP	denotes	Fig.
T2973	1371-1373	NNP	denotes	1B
T2974	1373-1374	,	denotes	,
T2975	1375-1385	NN	denotes	activation
T2976	1386-1388	IN	denotes	of
T2977	1389-1392	DT	denotes	the
T2978	1393-1396	NNP	denotes	BCR
T2979	1397-1399	CC	denotes	or
T2980	1400-1409	NN	denotes	treatment
T2981	1410-1414	IN	denotes	with
T2982	1415-1418	DT	denotes	the
T2983	1419-1430	JJ	denotes	DAG-mimetic
T2984	1431-1435	NNP	denotes	PdBu
T2985	1436-1445	VBD	denotes	increased
T2986	1446-1449	DT	denotes	the
T2987	1450-1456	NNS	denotes	levels
T2988	1457-1459	IN	denotes	of
T2989	1460-1465	NNP	denotes	HSP27
T2990	1466-1481	NN	denotes	phosphorylation
T2991	1482-1484	IN	denotes	at
T2992	1485-1488	CD	denotes	S82
T2993	1489-1491	IN	denotes	in
T2994	1492-1501	JJ	denotes	wild-type
T2995	1502-1506	NNP	denotes	DT40
T2996	1507-1508	NNP	denotes	B
T2997	1509-1514	NNS	denotes	cells
T2998	1514-1515	.	denotes	.
T2999	1516-1519	NNP	denotes	BCR
T3000	1520-1523	CC	denotes	and
T3001	1524-1531	JJ	denotes	phorbol
T3002	1532-1537	NN	denotes	ester
T3003	1538-1545	NNS	denotes	signals
T3004	1546-1550	VBD	denotes	were
T3005	1551-1555	RB	denotes	also
T3006	1556-1560	JJ	denotes	able
T3007	1561-1563	TO	denotes	to
T3008	1564-1572	VB	denotes	increase
T3009	1573-1578	NNP	denotes	HSP27
T3010	1579-1594	NN	denotes	phosphorylation
T3011	1595-1597	IN	denotes	in
T3012	1598-1602	CD	denotes	PKD1
T3013	1603-1605	CC	denotes	or
T3014	1606-1610	CD	denotes	PKD3
T3015	1611-1617	JJ	denotes	single
T3016	1618-1626	NN	denotes	knockout
T3017	1627-1631	NNP	denotes	DT40
T3018	1632-1633	NNP	denotes	B
T3019	1634-1639	NNS	denotes	cells
T3020	1640-1641	-LRB-	denotes	(
T3021	1641-1645	NNP	denotes	Fig.
T3022	1646-1648	NNP	denotes	1B
T3023	1648-1649	-RRB-	denotes	)
T3024	1649-1650	.	denotes	.
T3025	1651-1658	RB	denotes	However
T3026	1658-1659	,	denotes	,
T3027	1660-1663	NNP	denotes	BCR
T3028	1663-1664	:	denotes	-
T3029	1665-1668	CC	denotes	and
T3030	1669-1676	VB	denotes	phorbol
T3031	1677-1690	JJ	denotes	ester-induced
T3032	1691-1706	NN	denotes	phosphorylation
T3033	1707-1709	IN	denotes	of
T3034	1710-1715	NNP	denotes	HSP27
T3035	1716-1718	IN	denotes	on
T3036	1719-1722	NNP	denotes	S82
T3037	1723-1726	VBD	denotes	was
T3038	1727-1736	VBN	denotes	abolished
T3039	1737-1739	IN	denotes	in
T3040	1740-1741	NNP	denotes	B
T3041	1742-1747	NNS	denotes	cells
T3042	1748-1752	WDT	denotes	that
T3043	1753-1759	VBD	denotes	lacked
T3044	1760-1764	DT	denotes	both
T3045	1765-1769	NNP	denotes	PKD1
T3046	1770-1773	CC	denotes	and
T3047	1774-1778	NNP	denotes	PKD3
T3048	1779-1780	-LRB-	denotes	(
T3049	1780-1784	NNP	denotes	Fig.
T3050	1785-1787	NNP	denotes	1C
T3051	1787-1788	-RRB-	denotes	)
T3052	1788-1789	.	denotes	.
T3053	1790-1803	RB	denotes	Significantly
T3054	1803-1804	,	denotes	,
T3055	1805-1824	JJ	denotes	doxycycline-induced
T3056	1825-1835	NN	denotes	expression
T3057	1836-1838	IN	denotes	of
T3058	1839-1842	DT	denotes	the
T3059	1843-1852	NN	denotes	Flag-PKD3
T3060	1853-1862	NN	denotes	transgene
T3061	1863-1865	IN	denotes	in
T3062	1866-1869	DT	denotes	the
T3063	1870-1876	JJ	denotes	double
T3064	1877-1885	NN	denotes	knockout
T3065	1886-1891	NNS	denotes	cells
T3066	1892-1895	VBD	denotes	was
T3067	1896-1906	JJ	denotes	sufficient
T3068	1907-1909	TO	denotes	to
T3069	1910-1917	VB	denotes	restore
T3070	1918-1924	JJ	denotes	normal
T3071	1925-1935	NN	denotes	regulation
T3072	1936-1938	IN	denotes	of
T3073	1939-1944	NNP	denotes	HSP27
T3074	1945-1960	NN	denotes	phosphorylation
T3075	1961-1962	-LRB-	denotes	(
T3076	1962-1966	NNP	denotes	Fig.
T3077	1967-1969	NNP	denotes	1C
T3078	1969-1970	-RRB-	denotes	)
T3079	1970-1971	.	denotes	.
T3080	1972-1974	IN	denotes	In
T3081	1975-1983	NN	denotes	contrast
T3082	1983-1984	,	denotes	,
T3083	1985-1995	NN	denotes	expression
T3084	1996-1998	IN	denotes	of
T3085	1999-2000	DT	denotes	a
T3086	2001-2017	JJ	denotes	kinase-deficient
T3087	2018-2022	NN	denotes	PKD3
T3088	2023-2029	JJ	denotes	mutant
T3089	2030-2037	NN	denotes	protein
T3090	2038-2040	IN	denotes	in
T3091	2041-2044	DT	denotes	the
T3092	2045-2051	JJ	denotes	double
T3093	2052-2060	NN	denotes	knockout
T3094	2061-2066	NNS	denotes	cells
T3095	2067-2070	VBD	denotes	was
T3096	2071-2074	RB	denotes	not
T3097	2075-2079	JJ	denotes	able
T3098	2080-2082	TO	denotes	to
T3099	2083-2090	VB	denotes	restore
T3100	2091-2094	NNP	denotes	BCR
T3101	2094-2095	:	denotes	-
T3102	2096-2098	CC	denotes	or
T3103	2099-2106	VB	denotes	phorbol
T3104	2107-2120	JJ	denotes	ester-induced
T3105	2121-2126	NNP	denotes	HSP27
T3106	2127-2142	NN	denotes	phosphorylation
T3107	2143-2144	-LRB-	denotes	(
T3108	2144-2148	NNP	denotes	Fig.
T3109	2149-2151	NNP	denotes	1D
T3110	2151-2152	-RRB-	denotes	)
T3111	2152-2153	.	denotes	.
T3112	2154-2159	RB	denotes	Hence
T3113	2159-2160	,	denotes	,
T3114	2161-2165	NNP	denotes	PKD3
T3115	2166-2168	RB	denotes	as
T3116	2169-2173	RB	denotes	well
T3117	2174-2176	IN	denotes	as
T3118	2177-2181	NNP	denotes	PKD1
T3119	2182-2185	MD	denotes	can
T3120	2186-2194	VB	denotes	regulate
T3121	2195-2200	NNP	denotes	HSP27
T3122	2201-2216	NN	denotes	phosphorylation
T3123	2217-2220	CC	denotes	and
T3124	2221-2223	IN	denotes	in
T3125	2224-2228	NNP	denotes	DT40
T3126	2229-2230	NNP	denotes	B
T3127	2231-2236	NNS	denotes	cells
T3128	2237-2241	PRP	denotes	they
T3129	2242-2245	VBP	denotes	are
T3130	2246-2258	RB	denotes	functionally
T3131	2259-2268	JJ	denotes	redundant
T3132	2269-2271	IN	denotes	as
T3133	2272-2277	NNP	denotes	HSP27
T3134	2278-2285	NNS	denotes	kinases
T3135	2285-2286	.	denotes	.
T4218	2293-2301	NNP	denotes	Cellular
T4219	2302-2315	NN	denotes	proliferation
T4220	2316-2319	CC	denotes	and
T4221	2320-2328	NN	denotes	survival
T4222	2329-2331	IN	denotes	in
T4223	2332-2336	NNP	denotes	DT40
T4224	2337-2338	NNP	denotes	B
T4225	2339-2344	NNS	denotes	cells
T4226	2345-2352	VBG	denotes	lacking
T4227	2353-2363	NN	denotes	expression
T4228	2364-2366	IN	denotes	of
T4229	2367-2370	NNP	denotes	PKD
T4230	2371-2377	NN	denotes	family
T4231	2378-2385	VBZ	denotes	kinases
T4232	2386-2389	NNP	denotes	PKD
T4233	2390-2397	NNS	denotes	enzymes
T4234	2398-2402	VBP	denotes	have
T4235	2403-2413	RB	denotes	previously
T4236	2414-2418	VBN	denotes	been
T4237	2419-2425	VBN	denotes	linked
T4238	2426-2428	TO	denotes	to
T4239	2429-2432	DT	denotes	the
T4240	2433-2443	NN	denotes	regulation
T4241	2444-2446	IN	denotes	of
T4242	2447-2451	NN	denotes	cell
T4243	2452-2465	NN	denotes	proliferation
T4244	2466-2469	CC	denotes	and
T4245	2470-2478	NN	denotes	survival
T4246	2479-2480	-LRB-	denotes	(
T4247	2480-2488	VBN	denotes	reviewed
T4276	2635-2637	IN	denotes	in
T4277	2638-2641	DT	denotes	the
T4278	2642-2650	NN	denotes	presence
T4279	2651-2652	-LRB-	denotes	(
T4280	2652-2658	CD	denotes	PKD1/3
T4281	2658-2659	CD	denotes	−
T4282	2659-2660	NN	denotes	/
T4283	2660-2661	NN	denotes	−
T4284	2661-2662	:	denotes	:
T4285	2663-2672	NN	denotes	Flag-PKD3
T4286	2672-2673	NN	denotes	+
T4287	2673-2675	NN	denotes	ve
T4288	2675-2676	-RRB-	denotes	)
T4289	2677-2679	CC	denotes	or
T4290	2680-2687	NN	denotes	absence
T4291	2688-2689	-LRB-	denotes	(
T4292	2689-2695	CD	denotes	PKD1/3
T4293	2695-2696	CD	denotes	−
T4294	2696-2697	NN	denotes	/
T4295	2697-2698	NN	denotes	−
T4296	2698-2699	-RRB-	denotes	)
T4297	2700-2702	IN	denotes	of
T4298	2703-2714	NN	denotes	doxycycline
T4299	2715-2718	CC	denotes	and
T4300	2719-2728	VBD	denotes	monitored
T4301	2729-2740	JJ	denotes	exponential
T4302	2741-2747	NN	denotes	growth
T4303	2747-2748	.	denotes	.
T4304	2749-2751	IN	denotes	As
T4305	2752-2757	VBN	denotes	shown
T4306	2758-2760	IN	denotes	in
T4307	2761-2765	NNP	denotes	Fig.
T4308	2766-2768	NNP	denotes	2A
T4309	2768-2769	,	denotes	,
T4310	2770-2776	NNP	denotes	PKD1/3
T4311	2776-2777	VBD	denotes	−
T4312	2777-2778	CD	denotes	/
T4313	2778-2779	NN	denotes	−
T4314	2780-2785	NNS	denotes	cells
T4315	2786-2798	VBD	denotes	proliferated
T4316	2799-2812	RB	denotes	exponentially
T4317	2813-2816	CC	denotes	and
T4318	2817-2830	NN	denotes	re-expression
T4319	2831-2833	IN	denotes	of
T4320	2834-2843	NN	denotes	Flag-PKD3
T4321	2844-2846	IN	denotes	in
T4322	2847-2852	DT	denotes	these
T4323	2853-2858	NNS	denotes	cells
T4324	2859-2862	VBD	denotes	had
T4325	2863-2865	DT	denotes	no
T4326	2866-2872	NN	denotes	impact
T4327	2873-2875	IN	denotes	on
T4328	2876-2879	DT	denotes	the
T4329	2880-2884	NN	denotes	rate
T4330	2885-2887	IN	denotes	of
T4331	2888-2901	NN	denotes	proliferation
T4332	2901-2902	.	denotes	.
T4333	2903-2914	RB	denotes	Furthermore
T4334	2914-2915	,	denotes	,
T4335	2916-2919	DT	denotes	the
T4336	2920-2929	NN	denotes	viability
T4337	2930-2932	IN	denotes	of
T4338	2933-2939	CD	denotes	PKD1/3
T4339	2939-2940	CD	denotes	−
T4340	2940-2941	NN	denotes	/
T4341	2941-2942	NN	denotes	−
T4342	2943-2944	NNP	denotes	B
T4343	2945-2950	NNS	denotes	cells
T4344	2951-2957	IN	denotes	during
T4345	2958-2965	JJ	denotes	routine
T4346	2966-2975	NN	denotes	culturing
T4347	2976-2979	VBD	denotes	was
T4348	2980-2983	RB	denotes	not
T4349	2984-2997	RB	denotes	significantly
T4350	2998-3007	JJ	denotes	different
T4351	3008-3012	IN	denotes	from
T4352	3013-3017	DT	denotes	that
T4353	3018-3020	IN	denotes	of
T4354	3021-3030	JJ	denotes	wild-type
T4355	3031-3032	NNP	denotes	B
T4356	3033-3038	NNS	denotes	cells
T4357	3039-3040	-LRB-	denotes	(
T4358	3040-3044	NNS	denotes	data
T4359	3045-3048	RB	denotes	not
T4360	3049-3054	VBN	denotes	shown
T4361	3054-3055	-RRB-	denotes	)
T4362	3055-3056	.	denotes	.
T4363	3057-3059	PRP	denotes	It
T4364	3060-3063	VBD	denotes	was
T4365	3064-3069	VBN	denotes	noted
T4366	3070-3074	IN	denotes	that
T4367	3075-3078	DT	denotes	the
T4368	3079-3089	NN	denotes	population
T4369	3090-3098	VBG	denotes	doubling
T4370	3099-3103	NN	denotes	time
T4371	3104-3106	IN	denotes	of
T4372	3107-3113	CD	denotes	PKD1/3
T4373	3113-3114	CD	denotes	−
T4374	3114-3115	NN	denotes	/
T4375	3115-3116	NN	denotes	−
T4376	3117-3122	NNS	denotes	cells
T4377	3123-3126	VBD	denotes	was
T4378	3127-3135	RB	denotes	slightly
T4379	3136-3142	JJR	denotes	slower
T4380	3143-3147	IN	denotes	than
T4381	3148-3152	DT	denotes	that
T4382	3153-3155	IN	denotes	of
T4383	3156-3160	JJ	denotes	wild
T4384	3161-3165	NN	denotes	type
T4385	3166-3170	CD	denotes	DT40
T4386	3171-3176	NNS	denotes	cells
T4387	3177-3178	-LRB-	denotes	(
T4388	3178-3182	CD	denotes	12.7
T4389	3183-3184	CD	denotes	±
T4390	3185-3188	CD	denotes	2.8
T4391	3189-3190	NN	denotes	h
T4392	3191-3197	IN	denotes	versus
T4393	3198-3202	CD	denotes	10.2
T4394	3203-3204	CD	denotes	±
T4395	3205-3208	CD	denotes	0.4
T4396	3209-3210	NN	denotes	h
T4397	3210-3211	-RRB-	denotes	)
T4398	3212-3215	CC	denotes	but
T4399	3216-3219	DT	denotes	the
T4400	3220-3227	NN	denotes	failure
T4401	3228-3230	IN	denotes	of
T4402	3231-3235	CD	denotes	PKD3
T4403	3236-3249	NN	denotes	re-expression
T4404	3250-3252	TO	denotes	to
T4405	3253-3259	VB	denotes	modify
T4406	3260-3263	DT	denotes	the
T4407	3264-3277	NN	denotes	proliferation
T4408	3278-3282	NN	denotes	rate
T4409	3283-3285	IN	denotes	of
T4410	3286-3292	CD	denotes	PKD1/3
T4411	3292-3293	CD	denotes	−
T4412	3293-3294	NN	denotes	/
T4413	3294-3295	NN	denotes	−
T4414	3296-3301	NNS	denotes	cells
T4415	3302-3310	VBZ	denotes	suggests
T4416	3311-3315	IN	denotes	that
T4417	3316-3321	DT	denotes	these
T4418	3322-3327	JJ	denotes	small
T4419	3328-3339	NNS	denotes	differences
T4420	3340-3344	VBD	denotes	were
T4421	3345-3349	RBS	denotes	most
T4422	3350-3356	JJ	denotes	likely
T4423	3357-3360	DT	denotes	the
T4424	3361-3367	NN	denotes	result
T4425	3368-3370	IN	denotes	of
T4426	3371-3377	JJ	denotes	clonal
T4427	3378-3387	NN	denotes	variation
T4428	3388-3391	CC	denotes	and
T4429	3392-3396	VBD	denotes	were
T4430	3397-3400	RB	denotes	not
T4431	3401-3407	VBN	denotes	caused
T4432	3408-3420	RB	denotes	specifically
T4433	3421-3423	IN	denotes	by
T4434	3424-3428	NN	denotes	loss
T4435	3429-3431	IN	denotes	of
T4436	3432-3435	NNP	denotes	PKD
T4437	3436-3443	VBZ	denotes	enzymes
T4438	3443-3444	.	denotes	.
T4439	3445-3449	RB	denotes	Thus
T4440	3449-3450	,	denotes	,
T4441	3451-3454	NNP	denotes	PKD
T4442	3455-3461	NN	denotes	family
T4443	3462-3469	NNS	denotes	enzymes
T4444	3470-3473	VBP	denotes	are
T4445	3474-3477	RB	denotes	not
T4446	3478-3487	JJ	denotes	essential
T4447	3488-3491	IN	denotes	for
T4448	3492-3502	VBG	denotes	regulating
T4449	3503-3508	JJ	denotes	basal
T4450	3509-3517	NN	denotes	survival
T4451	3518-3521	CC	denotes	and
T4452	3522-3535	NN	denotes	proliferation
T4453	3536-3538	IN	denotes	of
T4454	3539-3543	NNP	denotes	DT40
T4455	3544-3545	NNP	denotes	B
T4456	3546-3551	NNS	denotes	cells
T4457	3551-3552	.	denotes	.
T4458	3553-3556	NNP	denotes	PKD
T4459	3557-3564	VBZ	denotes	enzymes
T4460	3564-3565	,	denotes	,
T4461	3566-3578	RB	denotes	specifically
T4462	3579-3583	CD	denotes	PKD1
T4463	3584-3587	CC	denotes	and
T4464	3588-3592	NNP	denotes	PKD2
T4465	3592-3593	,	denotes	,
T4466	3594-3598	VBP	denotes	have
T4467	3599-3609	RB	denotes	previously
T4468	3610-3614	VBN	denotes	been
T4469	3615-3621	VBN	denotes	linked
T4470	3622-3624	TO	denotes	to
T4471	3625-3626	DT	denotes	a
T4472	3627-3637	JJ	denotes	protective
T4473	3638-3642	NN	denotes	role
T4474	3643-3650	IN	denotes	against
T4475	3651-3660	JJ	denotes	oxidative
T4476	3661-3675	JJ	denotes	stress-induced
T4477	3676-3682	NN	denotes	injury
T4478	3683-3685	IN	denotes	in
T4479	3686-3689	NNP	denotes	3T3
T4480	3690-3700	NN	denotes	fibroblast
T4481	3700-3701	,	denotes	,
T4482	3702-3706	NNP	denotes	HeLa
T4483	3707-3710	CC	denotes	and
T4484	3711-3721	JJ	denotes	epithelial
T4485	3722-3726	NN	denotes	cell
T4486	3727-3732	NNS	denotes	lines
T4487	3733-3734	NNP	denotes	[
T4488	3734-3739	CD	denotes	17,30
T4489	3740-3742	CD	denotes	32
T4490	3742-3743	NN	denotes	]
T4491	3743-3744	.	denotes	.
T4492	3745-3747	PRP	denotes	We
T4493	3748-3757	RB	denotes	therefore
T4494	3758-3767	VBD	denotes	addressed
T4495	3768-3771	DT	denotes	the
T4496	3772-3776	NN	denotes	role
T4497	3777-3779	IN	denotes	of
T4498	3780-3783	NNP	denotes	PKD
T4499	3784-3790	NN	denotes	family
T4500	3791-3798	NNS	denotes	kinases
T4501	3799-3801	IN	denotes	in
T4502	3802-3812	VBG	denotes	regulating
T4503	3813-3814	NNP	denotes	B
T4504	3815-3819	NN	denotes	cell
T4505	3820-3828	NN	denotes	survival
T4506	3829-3831	IN	denotes	in
T4507	3832-3840	NN	denotes	response
T4508	3841-3843	TO	denotes	to
T4509	3844-3853	JJ	denotes	oxidative
T4510	3854-3860	NN	denotes	stress
T4511	3861-3864	CC	denotes	and
T4512	3865-3870	JJ	denotes	other
T4513	3871-3877	NN	denotes	stress
T4514	3878-3885	NNS	denotes	stimuli
T4515	3885-3886	.	denotes	.
T4516	3887-3889	IN	denotes	As
T4517	3890-3895	VBN	denotes	shown
T4518	3896-3898	IN	denotes	in
T4519	3899-3903	NNP	denotes	Fig.
T4520	3904-3906	NNP	denotes	2B
T4521	3906-3907	,	denotes	,
T4522	3908-3912	NN	denotes	loss
T4523	3913-3915	IN	denotes	of
T4524	3916-3922	CD	denotes	PKD1/3
T4525	3923-3933	NN	denotes	expression
T4526	3934-3937	VBD	denotes	had
T4527	3938-3940	DT	denotes	no
T4528	3941-3952	JJ	denotes	significant
T4529	3953-3959	NN	denotes	impact
T4530	3960-3962	IN	denotes	on
T4531	3963-3966	DT	denotes	the
T4532	3967-3975	NN	denotes	survival
T4533	3976-3978	IN	denotes	of
T4534	3979-3983	NNP	denotes	DT40
T4535	3984-3985	NNP	denotes	B
T4536	3986-3991	NNS	denotes	cells
T4537	3992-3994	IN	denotes	in
T4538	3995-4003	NN	denotes	response
T4539	4004-4006	TO	denotes	to
T4540	4007-4020	JJ	denotes	mitochondrial
T4541	4021-4027	NN	denotes	stress
T4542	4028-4035	NNS	denotes	stimuli
T4543	4036-4037	-LRB-	denotes	(
T4544	4037-4041	CD	denotes	H2O2
T4545	4042-4044	CC	denotes	or
T4546	4045-4050	NN	denotes	serum
T4547	4051-4062	NN	denotes	deprivation
T4548	4062-4063	-RRB-	denotes	)
T4549	4063-4064	:	denotes	;
T4550	4065-4068	NNP	denotes	DNA
T4551	4069-4077	VBG	denotes	damaging
T4552	4078-4084	NNS	denotes	agents
T4553	4085-4086	-LRB-	denotes	(
T4554	4086-4095	NN	denotes	etoposide
T4555	4096-4098	CC	denotes	or
T4556	4099-4110	NN	denotes	doxorubicin
T4557	4110-4111	-RRB-	denotes	)
T4558	4111-4112	:	denotes	;
T4559	4113-4115	NNP	denotes	ER
T4560	4116-4123	NN	denotes	pathway
T4561	4124-4130	NN	denotes	stress
T4562	4131-4134	JJ	denotes	due
T4563	4135-4137	TO	denotes	to
T4564	4138-4145	NN	denotes	calcium
T4565	4146-4154	NN	denotes	overload
T4566	4155-4156	-LRB-	denotes	(
T4567	4156-4168	NN	denotes	thapsigargin
T4568	4168-4169	-RRB-	denotes	)
T4569	4170-4172	CC	denotes	or
T4570	4173-4182	VBG	denotes	following
T4571	4183-4192	JJ	denotes	prolonged
T4572	4193-4202	NN	denotes	treatment
T4573	4203-4207	IN	denotes	with
T4574	4208-4215	NN	denotes	phorbol
T4575	4216-4222	NNS	denotes	esters
T4576	4223-4225	CC	denotes	or
T4577	4226-4238	NNP	denotes	Trichostatin
T4578	4239-4240	NNP	denotes	A
T4579	4240-4241	,	denotes	,
T4580	4242-4244	DT	denotes	an
T4581	4245-4254	NN	denotes	inhibitor
T4582	4255-4257	IN	denotes	of
T4583	4258-4263	NN	denotes	class
T4584	4264-4268	NNP	denotes	I/II
T4585	4269-4274	NNP	denotes	HDACs
T4586	4274-4275	.	denotes	.
T4587	4276-4280	RB	denotes	Thus
T4588	4280-4281	,	denotes	,
T4589	4282-4285	NNP	denotes	PKD
T4590	4286-4293	NNS	denotes	kinases
T4591	4294-4296	VBP	denotes	do
T4592	4297-4300	RB	denotes	not
T4593	4301-4305	VB	denotes	play
T4594	4306-4308	DT	denotes	an
T4595	4309-4318	JJ	denotes	essential
T4596	4319-4323	NN	denotes	role
T4597	4324-4326	IN	denotes	in
T4598	4327-4337	VBG	denotes	regulating
T4599	4338-4339	NNP	denotes	B
T4600	4340-4344	NN	denotes	cell
T4601	4345-4353	NN	denotes	survival
T4602	4354-4356	IN	denotes	in
T4603	4357-4365	NN	denotes	response
T4604	4366-4368	TO	denotes	to
T4605	4369-4370	DT	denotes	a
T4606	4371-4376	NN	denotes	range
T4607	4377-4379	IN	denotes	of
T4608	4380-4389	JJ	denotes	different
T4609	4390-4396	NN	denotes	stress
T4610	4397-4404	NNS	denotes	stimuli
T4611	4404-4405	.	denotes	.
T5769	4412-4419	NN	denotes	Antigen
T5770	4420-4428	NN	denotes	receptor
T5771	4429-4438	VBN	denotes	regulated
T5772	4439-4449	JJ	denotes	signalling
T5773	4450-4458	NNS	denotes	pathways
T5774	4459-4461	IN	denotes	in
T5775	4462-4470	NNP	denotes	PKD-null
T5776	4471-4475	NNP	denotes	DT40
T5777	4476-4477	NNP	denotes	B
T5778	4478-4483	NNS	denotes	cells
T5779	4484-4486	TO	denotes	To
T5780	4487-4494	RBR	denotes	further
T5781	4495-4502	VB	denotes	explore
T5782	4503-4506	DT	denotes	the
T5783	4507-4519	NN	denotes	contribution
T5784	4520-4522	IN	denotes	of
T5785	4523-4526	NNP	denotes	PKD
T5786	4527-4534	VBZ	denotes	kinases
T5787	4535-4537	TO	denotes	to
T5788	4538-4542	NNP	denotes	DT40
T5789	4543-4544	NNP	denotes	B
T5790	4545-4549	NN	denotes	cell
T5791	4550-4557	NN	denotes	biology
T5792	4558-4560	PRP	denotes	we
T5793	4561-4573	VBD	denotes	investigated
T5794	4574-4581	IN	denotes	whether
T5795	4582-4590	JJ	denotes	specific
T5796	4591-4604	JJ	denotes	BCR-regulated
T5797	4605-4615	JJ	denotes	signalling
T5798	4616-4622	NNS	denotes	events
T5799	4623-4627	VBD	denotes	were
T5800	4628-4637	JJ	denotes	defective
T5801	4638-4640	IN	denotes	in
T5802	4641-4644	DT	denotes	the
T5803	4645-4653	NNP	denotes	PKD-null
T5804	4654-4655	NNP	denotes	B
T5805	4656-4661	NNS	denotes	cells
T5806	4661-4662	.	denotes	.
T5807	4663-4670	JJ	denotes	Initial
T5808	4671-4682	NNS	denotes	experiments
T5809	4683-4691	VBD	denotes	revealed
T5810	4692-4696	IN	denotes	that
T5811	4697-4704	NN	denotes	surface
T5812	4705-4715	NN	denotes	expression
T5813	4716-4718	IN	denotes	of
T5814	4719-4722	DT	denotes	the
T5815	4723-4726	NNP	denotes	BCR
T5816	4727-4730	VBD	denotes	was
T5817	4731-4738	VBN	denotes	reduced
T5818	4739-4741	IN	denotes	in
T5819	4742-4748	CD	denotes	PKD1/3
T5820	4748-4749	CD	denotes	−
T5821	4749-4750	NN	denotes	/
T5822	4750-4751	NN	denotes	−
T5823	4752-4753	-LRB-	denotes	(
T5824	4753-4756	CC	denotes	and
T5825	4757-4759	IN	denotes	in
T5826	4760-4766	CD	denotes	PKD1/3
T5827	4766-4767	CD	denotes	−
T5828	4767-4768	NN	denotes	/
T5829	4768-4769	NN	denotes	−
T5830	4769-4770	:	denotes	:
T5831	4770-4779	NN	denotes	Flag-PKD3
T5832	4779-4780	NN	denotes	+
T5833	4780-4782	NN	denotes	ve
T5834	4782-4783	-RRB-	denotes	)
T5835	4784-4789	NNS	denotes	cells
T5836	4790-4798	VBN	denotes	compared
T5837	4799-4801	TO	denotes	to
T5838	4802-4811	JJ	denotes	wild-type
T5839	4812-4816	NNP	denotes	DT40
T5840	4817-4818	NNP	denotes	B
T5841	4819-4824	NNS	denotes	cells
T5842	4825-4826	-LRB-	denotes	(
T5843	4826-4830	NNP	denotes	Fig.
T5844	4831-4833	NNP	denotes	3A
T5845	4834-4837	CC	denotes	and
T5846	4838-4842	NNS	denotes	data
T5847	4843-4846	RB	denotes	not
T5848	4847-4852	VBN	denotes	shown
T5849	4852-4853	-RRB-	denotes	)
T5850	4853-4854	.	denotes	.
T5851	4855-4867	RB	denotes	Nevertheless
T5852	4867-4868	,	denotes	,
T5853	4869-4885	JJ	denotes	BCR-crosslinking
T5854	4886-4888	IN	denotes	of
T5855	4889-4895	CD	denotes	PKD1/3
T5856	4895-4896	CD	denotes	−
T5857	4896-4897	NN	denotes	/
T5858	4897-4898	NN	denotes	−
T5859	4899-4904	NNS	denotes	cells
T5860	4905-4908	VBD	denotes	was
T5861	4909-4919	JJ	denotes	sufficient
T5862	4920-4922	TO	denotes	to
T5863	4923-4929	VB	denotes	induce
T5864	4930-4933	DT	denotes	the
T5865	4934-4944	NN	denotes	activation
T5866	4945-4947	IN	denotes	of
T5867	4948-4949	DT	denotes	a
T5868	4950-4956	NN	denotes	number
T5869	4957-4959	IN	denotes	of
T5870	4960-4970	VBG	denotes	signalling
T5871	4971-4979	NNS	denotes	cascades
T5872	4979-4980	,	denotes	,
T5873	4981-4988	JJ	denotes	similar
T5874	4989-4991	TO	denotes	to
T5875	4992-4996	DT	denotes	that
T5876	4997-5005	VBN	denotes	observed
T5877	5006-5008	IN	denotes	in
T5878	5009-5018	JJ	denotes	wild-type
T5879	5019-5024	NNS	denotes	cells
T5880	5025-5026	-LRB-	denotes	(
T5881	5026-5030	NNP	denotes	Fig.
T5882	5031-5033	NNP	denotes	3B
T5883	5033-5034	-RRB-	denotes	)
T5884	5034-5035	.	denotes	.
T5885	5036-5041	RB	denotes	Hence
T5886	5041-5042	,	denotes	,
T5887	5043-5054	JJ	denotes	BCR-induced
T5888	5055-5065	NN	denotes	activation
T5889	5066-5068	IN	denotes	of
T5890	5069-5072	DT	denotes	the
T5891	5073-5076	NNP	denotes	Akt
T5892	5076-5077	,	denotes	,
T5893	5078-5086	NNP	denotes	mTOR/p70
T5894	5087-5089	NNP	denotes	S6
T5895	5090-5096	NN	denotes	kinase
T5896	5097-5098	-LRB-	denotes	(
T5897	5098-5100	IN	denotes	as
T5898	5101-5106	VBN	denotes	shown
T5899	5107-5109	IN	denotes	by
T5900	5110-5112	CD	denotes	S6
T5901	5113-5122	JJ	denotes	ribosomal
T5902	5123-5130	NN	denotes	protein
T5903	5131-5146	NN	denotes	phosphorylation
T5904	5146-5147	-RRB-	denotes	)
T5905	5148-5151	CC	denotes	and
T5906	5152-5156	NNP	denotes	MAPK
T5907	5157-5167	VBG	denotes	signalling
T5908	5168-5176	NNS	denotes	pathways
T5909	5177-5180	VBD	denotes	was
T5910	5181-5188	RB	denotes	clearly
T5911	5189-5199	JJ	denotes	detectable
T5912	5200-5202	IN	denotes	in
T5913	5203-5214	NNP	denotes	PKD1/3-null
T5914	5215-5216	NNP	denotes	B
T5915	5217-5222	NNS	denotes	cells
T5916	5223-5224	-LRB-	denotes	(
T5917	5224-5228	NNP	denotes	Fig.
T5918	5229-5231	NNP	denotes	3B
T5919	5231-5232	-RRB-	denotes	)
T5920	5232-5233	.	denotes	.
T5921	5234-5245	RB	denotes	Furthermore
T5922	5245-5246	,	denotes	,
T5923	5247-5255	JJ	denotes	enhanced
T5924	5256-5264	NN	denotes	tyrosine
T5925	5265-5280	NN	denotes	phosphorylation
T5926	5281-5283	IN	denotes	of
T5927	5284-5292	JJ	denotes	multiple
T5928	5293-5301	JJ	denotes	cellular
T5929	5302-5310	NNS	denotes	proteins
T5930	5311-5313	RB	denotes	as
T5931	5314-5318	RB	denotes	well
T5932	5319-5321	IN	denotes	as
T5933	5322-5324	DT	denotes	an
T5934	5325-5333	NN	denotes	increase
T5935	5334-5336	IN	denotes	in
T5936	5337-5350	JJ	denotes	intracellular
T5937	5351-5358	NN	denotes	calcium
T5938	5359-5365	NNS	denotes	levels
T5939	5366-5369	VBD	denotes	was
T5940	5370-5374	RB	denotes	also
T5941	5375-5383	VBN	denotes	observed
T5942	5384-5393	VBG	denotes	following
T5943	5394-5397	NNP	denotes	BCR
T5944	5398-5409	NN	denotes	stimulation
T5945	5410-5412	IN	denotes	of
T5946	5413-5424	NNP	denotes	PKD1/3-null
T5947	5425-5426	NNP	denotes	B
T5948	5427-5432	NNS	denotes	cells
T5949	5433-5434	-LRB-	denotes	(
T5950	5434-5438	NNS	denotes	data
T5951	5439-5442	RB	denotes	not
T5952	5443-5448	VBN	denotes	shown
T5953	5448-5449	-RRB-	denotes	)
T5954	5449-5450	.	denotes	.
T5955	5451-5453	PRP	denotes	We
T5956	5454-5457	VBD	denotes	did
T5957	5458-5465	VB	denotes	observe
T5958	5466-5470	IN	denotes	that
T5959	5471-5474	DT	denotes	the
T5960	5475-5483	NN	denotes	strength
T5961	5484-5486	IN	denotes	of
T5962	5487-5490	NNP	denotes	BCR
T5963	5491-5492	-LRB-	denotes	(
T5964	5492-5495	CC	denotes	but
T5965	5496-5499	RB	denotes	not
T5966	5500-5507	VB	denotes	phorbol
T5967	5508-5513	NN	denotes	ester
T5968	5513-5514	-RRB-	denotes	)
T5969	5514-5515	:	denotes	-
T5970	5515-5522	VBD	denotes	induced
T5971	5523-5533	NN	denotes	regulation
T5972	5534-5536	IN	denotes	of
T5973	5537-5540	DT	denotes	the
T5974	5541-5550	JJ	denotes	Erk1-RSK1
T5975	5551-5561	NN	denotes	signalling
T5976	5562-5569	NN	denotes	pathway
T5977	5570-5573	VBD	denotes	was
T5978	5574-5581	VBN	denotes	reduced
T5979	5582-5584	IN	denotes	in
T5980	5585-5591	CD	denotes	PKD1/3
T5981	5591-5592	CD	denotes	−
T5982	5592-5593	NN	denotes	/
T5983	5593-5594	NN	denotes	−
T5984	5595-5596	NNP	denotes	B
T5985	5597-5602	NNS	denotes	cells
T5986	5603-5611	VBN	denotes	compared
T5987	5612-5614	TO	denotes	to
T5988	5615-5624	JJ	denotes	wild-type
T5989	5625-5626	NNP	denotes	B
T5990	5627-5632	NNS	denotes	cells
T5991	5633-5634	-LRB-	denotes	(
T5992	5634-5638	NNP	denotes	Fig.
T5993	5639-5641	NNP	denotes	3B
T5994	5641-5642	-RRB-	denotes	)
T5995	5642-5643	.	denotes	.
T5996	5644-5647	CD	denotes	One
T5997	5648-5662	NN	denotes	interpretation
T5998	5663-5665	IN	denotes	of
T5999	5666-5670	DT	denotes	this
T6000	5671-5675	NN	denotes	data
T6001	5676-5678	VBZ	denotes	is
T6002	5679-5683	IN	denotes	that
T6003	5684-5687	NNP	denotes	PKD
T6004	5688-5695	VBZ	denotes	enzymes
T6005	5696-5699	MD	denotes	may
T6006	5700-5708	VB	denotes	modulate
T6007	5709-5712	NNP	denotes	Erk
T6008	5713-5723	NN	denotes	activation
T6009	5723-5724	.	denotes	.
T6010	5725-5731	RB	denotes	Indeed
T6011	5731-5732	,	denotes	,
T6012	5733-5736	NNP	denotes	PKD
T6013	5737-5744	NNS	denotes	enzymes
T6014	5745-5749	VBP	denotes	have
T6015	5750-5760	RB	denotes	previously
T6016	5761-5765	VBN	denotes	been
T6017	5766-5772	VBN	denotes	linked
T6018	5773-5775	TO	denotes	to
T6019	5776-5779	DT	denotes	the
T6020	5780-5786	NN	denotes	growth
T6021	5787-5803	JJ	denotes	factor-regulated
T6022	5804-5807	NNP	denotes	Erk
T6023	5808-5818	NN	denotes	signalling
T6024	5819-5821	IN	denotes	in
T6025	5822-5832	NN	denotes	fibroblast
T6026	5833-5836	CC	denotes	and
T6027	5837-5848	JJ	denotes	endothelial
T6028	5849-5853	NN	denotes	cell
T6029	5854-5859	NNS	denotes	lines
T6030	5860-5861	NNP	denotes	[
T6031	5861-5863	CD	denotes	33
T6032	5864-5866	CD	denotes	35
T6033	5866-5867	NN	denotes	]
T6034	5867-5868	.	denotes	.
T6035	5869-5876	RB	denotes	However
T6036	5876-5877	,	denotes	,
T6037	5878-5889	JJ	denotes	BCR-induced
T6038	5890-5893	NNP	denotes	Erk
T6039	5894-5909	NN	denotes	phosphorylation
T6040	5910-5913	VBD	denotes	was
T6041	5914-5918	RB	denotes	also
T6042	5919-5926	VBN	denotes	reduced
T6043	5927-5929	IN	denotes	in
T6044	5930-5936	CD	denotes	PKD1/3
T6045	5936-5937	CD	denotes	−
T6046	5937-5938	NN	denotes	/
T6047	5938-5939	SYM	denotes	−
T6048	5939-5940	:	denotes	-
T6049	5940-5949	NN	denotes	Flag-PKD3
T6050	5949-5950	NN	denotes	+
T6051	5951-5952	NNP	denotes	B
T6052	5953-5958	NNS	denotes	cells
T6053	5959-5960	-LRB-	denotes	(
T6054	5960-5964	NNS	denotes	data
T6055	5965-5968	RB	denotes	not
T6056	5969-5974	VBN	denotes	shown
T6057	5974-5975	-RRB-	denotes	)
T6058	5976-5986	VBG	denotes	suggesting
T6059	5987-5991	IN	denotes	that
T6060	5992-5999	VBN	denotes	reduced
T6061	6000-6003	NNP	denotes	BCR
T6062	6004-6010	NNS	denotes	levels
T6063	6011-6013	IN	denotes	on
T6064	6014-6017	DT	denotes	the
T6065	6018-6025	NN	denotes	surface
T6066	6026-6028	IN	denotes	of
T6067	6029-6035	CD	denotes	PKD1/3
T6068	6035-6036	CD	denotes	−
T6069	6036-6037	NN	denotes	/
T6070	6037-6038	NN	denotes	−
T6071	6039-6040	-LRB-	denotes	(
T6072	6040-6043	CC	denotes	and
T6073	6044-6050	NNP	denotes	PKD1/3
T6074	6050-6051	VBD	denotes	−
T6075	6051-6052	CD	denotes	/
T6076	6052-6053	SYM	denotes	−
T6077	6053-6054	:	denotes	-
T6078	6054-6063	NN	denotes	Flag-PKD3
T6079	6063-6064	NN	denotes	+
T6080	6064-6065	-RRB-	denotes	)
T6081	6066-6067	NNP	denotes	B
T6082	6068-6073	NNS	denotes	cells
T6083	6074-6077	MD	denotes	may
T6084	6078-6084	PRP	denotes	itself
T6085	6085-6091	VB	denotes	impact
T6086	6092-6094	IN	denotes	on
T6087	6095-6098	DT	denotes	the
T6088	6099-6107	NN	denotes	strength
T6089	6108-6110	IN	denotes	of
T6090	6111-6121	NN	denotes	activation
T6091	6122-6124	IN	denotes	of
T6092	6125-6129	DT	denotes	this
T6093	6130-6138	JJ	denotes	specific
T6094	6139-6152	JJ	denotes	intracellular
T6095	6153-6163	NN	denotes	signalling
T6096	6164-6171	NN	denotes	pathway
T6097	6171-6172	.	denotes	.
T6098	6173-6175	TO	denotes	To
T6099	6176-6182	VB	denotes	search
T6100	6183-6186	IN	denotes	for
T6101	6187-6192	JJ	denotes	other
T6102	6193-6202	JJ	denotes	potential
T6103	6203-6206	NNP	denotes	PKD
T6104	6207-6214	NNS	denotes	targets
T6105	6215-6219	WDT	denotes	that
T6106	6220-6223	MD	denotes	may
T6107	6224-6228	VB	denotes	show
T6108	6229-6238	JJ	denotes	defective
T6109	6239-6249	NN	denotes	regulation
T6110	6250-6252	IN	denotes	in
T6111	6253-6259	NNP	denotes	PKD1/3
T6112	6259-6260	NNP	denotes	−
T6113	6260-6261	NNP	denotes	/
T6114	6261-6262	NNP	denotes	−
T6115	6263-6267	NNP	denotes	DT40
T6116	6268-6269	NNP	denotes	B
T6117	6270-6275	NNS	denotes	cells
T6118	6275-6276	,	denotes	,
T6119	6277-6279	PRP	denotes	we
T6120	6280-6284	VBD	denotes	used
T6121	6285-6286	DT	denotes	a
T6122	6287-6290	NNP	denotes	PKD
T6123	6291-6300	VB	denotes	substrate
T6124	6301-6317	JJ	denotes	phospho-antibody
T6125	6318-6322	IN	denotes	that
T6126	6323-6333	VBZ	denotes	recognises
T6127	6334-6343	NN	denotes	consensus
T6128	6344-6359	NN	denotes	phosphorylation
T6129	6360-6369	NNS	denotes	sequences
T6130	6370-6378	VBN	denotes	targeted
T6131	6379-6381	IN	denotes	by
T6132	6382-6385	NNP	denotes	PKD
T6133	6386-6393	VBZ	denotes	enzymes
T6134	6394-6395	-LRB-	denotes	(
T6135	6395-6404	NNP	denotes	LxRxxpS/T
T6136	6404-6405	-RRB-	denotes	)
T6137	6406-6407	NNP	denotes	[
T6138	6407-6409	CD	denotes	36
T6139	6409-6410	NNP	denotes	]
T6140	6410-6411	.	denotes	.
T6141	6412-6414	IN	denotes	As
T6142	6415-6420	VBN	denotes	shown
T6143	6421-6423	IN	denotes	in
T6144	6424-6428	NNP	denotes	Fig.
T6145	6429-6431	NNP	denotes	3C
T6146	6431-6432	,	denotes	,
T6147	6433-6440	NN	denotes	phorbol
T6148	6441-6446	NN	denotes	ester
T6149	6446-6447	:	denotes	-
T6150	6448-6451	CC	denotes	and
T6151	6452-6463	JJ	denotes	BCR-induced
T6152	6464-6479	NN	denotes	phosphorylation
T6153	6480-6482	IN	denotes	of
T6154	6483-6491	JJ	denotes	cellular
T6155	6492-6502	NNS	denotes	substrates
T6156	6503-6511	VBN	denotes	detected
T6157	6512-6514	IN	denotes	by
T6158	6515-6519	DT	denotes	this
T6159	6520-6536	NN	denotes	phospho-antibody
T6160	6537-6540	VBD	denotes	was
T6161	6541-6548	JJ	denotes	similar
T6162	6549-6551	IN	denotes	in
T6163	6552-6561	JJ	denotes	wild-type
T6164	6562-6565	CC	denotes	and
T6165	6566-6572	JJ	denotes	PKD1/3
T6166	6572-6573	NN	denotes	−
T6167	6573-6574	NN	denotes	/
T6168	6574-6575	NN	denotes	−
T6169	6576-6581	NNS	denotes	cells
T6170	6582-6585	CC	denotes	and
T6171	6586-6588	VBZ	denotes	is
T6172	6589-6598	RB	denotes	therefore
T6173	6599-6610	JJ	denotes	independent
T6174	6611-6613	IN	denotes	of
T6175	6614-6617	NNP	denotes	PKD
T6176	6618-6625	VBZ	denotes	enzymes
T6177	6625-6626	.	denotes	.
T6178	6627-6634	RB	denotes	However
T6179	6634-6635	,	denotes	,
T6180	6636-6648	NN	denotes	pretreatment
T6181	6649-6651	IN	denotes	of
T6182	6652-6656	DT	denotes	both
T6183	6657-6666	JJ	denotes	wild-type
T6184	6667-6670	CC	denotes	and
T6185	6671-6677	JJ	denotes	PKD1/3
T6186	6677-6678	NN	denotes	−
T6187	6678-6679	NN	denotes	/
T6188	6679-6680	NN	denotes	−
T6189	6681-6685	NNP	denotes	DT40
T6190	6686-6687	NNP	denotes	B
T6191	6688-6693	NNS	denotes	cells
T6192	6694-6698	IN	denotes	with
T6193	6699-6708	NNP	denotes	GF109203X
T6194	6708-6709	,	denotes	,
T6195	6710-6711	DT	denotes	a
T6196	6712-6730	NN	denotes	bisindoylmaleimide
T6197	6731-6741	NN	denotes	derivative
T6198	6742-6746	WDT	denotes	that
T6199	6747-6755	VBZ	denotes	inhibits
T6200	6756-6760	NNS	denotes	PKCs
T6201	6761-6770	VBD	denotes	prevented
T6202	6771-6774	DT	denotes	the
T6203	6775-6784	NN	denotes	induction
T6204	6785-6787	IN	denotes	of
T6205	6788-6796	NNS	denotes	proteins
T6206	6797-6801	WDT	denotes	that
T6207	6802-6809	VBP	denotes	contain
T6208	6810-6824	VBN	denotes	phosphorylated
T6209	6825-6833	NNP	denotes	LxRxxS/T
T6210	6834-6840	NNS	denotes	motifs
T6211	6840-6841	.	denotes	.
T6212	6842-6846	RB	denotes	Thus
T6213	6847-6851	NN	denotes	loss
T6214	6852-6854	IN	denotes	of
T6215	6855-6861	NNP	denotes	PKD1/3
T6216	6862-6869	VBZ	denotes	enzymes
T6217	6870-6874	VBZ	denotes	does
T6218	6875-6878	RB	denotes	not
T6219	6879-6887	RB	denotes	globally
T6220	6888-6895	VB	denotes	disrupt
T6221	6896-6899	DT	denotes	the
T6222	6900-6915	NN	denotes	phosphorylation
T6223	6916-6918	IN	denotes	of
T6224	6919-6927	JJ	denotes	cellular
T6225	6928-6936	NNS	denotes	proteins
T6226	6937-6941	WDT	denotes	that
T6227	6942-6949	VBP	denotes	contain
T6228	6950-6959	NNP	denotes	LxRxxpS/T
T6229	6960-6966	NNS	denotes	motifs
T6230	6966-6967	.	denotes	.
T6231	6968-6972	DT	denotes	This
T6232	6973-6979	NN	denotes	result
T6233	6980-6982	VBZ	denotes	is
T6234	6983-6990	RB	denotes	perhaps
T6235	6991-6994	RB	denotes	not
T6236	6995-7005	JJ	denotes	surprising
T6237	7006-7008	IN	denotes	as
T6238	7009-7017	NNP	denotes	LxRxxS/T
T6239	7018-7024	NNS	denotes	motifs
T6240	7025-7029	RB	denotes	also
T6241	7030-7033	VBP	denotes	act
T6242	7034-7036	RB	denotes	as
T6243	7037-7041	JJ	denotes	good
T6244	7042-7052	NNS	denotes	substrates
T6245	7053-7056	IN	denotes	for
T6246	7057-7062	JJ	denotes	other
T6247	7063-7079	JJ	denotes	serine/threonine
T6248	7080-7087	NNS	denotes	kinases
T6249	7088-7092	JJ	denotes	such
T6250	7093-7095	IN	denotes	as
T6251	7096-7104	NNP	denotes	MAPKAPK2
T6252	7104-7105	.	denotes	.
T6253	7106-7113	RB	denotes	However
T6254	7114-7119	DT	denotes	these
T6255	7120-7131	NNS	denotes	experiments
T6256	7132-7134	VBP	denotes	do
T6257	7135-7142	VB	denotes	provide
T6258	7143-7150	JJ	denotes	further
T6259	7151-7159	NN	denotes	evidence
T6260	7160-7164	IN	denotes	that
T6261	7165-7180	JJ	denotes	phosphospecific
T6262	7181-7189	NN	denotes	antisera
T6263	7190-7193	VBP	denotes	are
T6264	7194-7197	RB	denotes	not
T6265	7198-7210	RB	denotes	sufficiently
T6266	7211-7220	JJ	denotes	selective
T6267	7221-7223	TO	denotes	to
T6268	7224-7226	VB	denotes	be
T6269	7227-7237	VBN	denotes	designated
T6270	7238-7244	NN	denotes	kinase
T6271	7245-7253	JJ	denotes	specific
T6272	7254-7263	JJ	denotes	substrate
T6273	7264-7272	NN	denotes	antisera
T6274	7272-7273	.	denotes	.
T6275	7274-7285	JJ	denotes	BCR-induced
T6276	7286-7296	JJ	denotes	signalling
T6277	7297-7305	NNS	denotes	pathways
T6278	7306-7315	VBP	denotes	culminate
T6279	7316-7318	IN	denotes	in
T6280	7319-7322	DT	denotes	the
T6281	7323-7333	NN	denotes	activation
T6282	7334-7336	IN	denotes	of
T6283	7337-7341	NN	denotes	gene
T6284	7342-7355	NN	denotes	transcription
T6285	7356-7362	NNS	denotes	events
T6286	7363-7367	WDT	denotes	that
T6287	7368-7375	VBP	denotes	control
T6288	7376-7377	NNP	denotes	B
T6289	7378-7382	NN	denotes	cell
T6290	7383-7391	NN	denotes	survival
T6291	7391-7392	,	denotes	,
T6292	7393-7406	NN	denotes	proliferation
T6293	7407-7410	CC	denotes	and
T6294	7411-7419	NN	denotes	function
T6295	7419-7420	.	denotes	.
T6296	7421-7423	IN	denotes	In
T6297	7424-7428	DT	denotes	this
T6298	7429-7436	NN	denotes	context
T6299	7436-7437	,	denotes	,
T6300	7438-7440	PRP	denotes	it
T6301	7441-7444	VBZ	denotes	has
T6302	7445-7449	VBN	denotes	been
T6303	7450-7458	VBN	denotes	proposed
T6304	7459-7463	IN	denotes	that
T6305	7464-7467	NNP	denotes	PKD
T6306	7468-7474	NN	denotes	family
T6307	7475-7482	NNS	denotes	members
T6308	7483-7490	NN	denotes	control
T6309	7491-7493	IN	denotes	of
T6310	7494-7498	NN	denotes	gene
T6311	7499-7512	NN	denotes	transcription
T6312	7513-7520	IN	denotes	through
T6313	7521-7531	NN	denotes	activation
T6314	7532-7534	IN	denotes	of
T6315	7535-7538	DT	denotes	the
T6316	7539-7543	NNP	denotes	NFκB
T6317	7544-7557	NN	denotes	transcription
T6318	7558-7564	NN	denotes	factor
T6319	7564-7565	.	denotes	.
T6320	7566-7570	RB	denotes	Thus
T6321	7570-7571	,	denotes	,
T6322	7572-7584	JJ	denotes	PKD-mediated
T6323	7585-7595	NN	denotes	activation
T6324	7596-7598	IN	denotes	of
T6325	7599-7603	NNP	denotes	NFκB
T6326	7604-7610	VBZ	denotes	occurs
T6327	7611-7621	JJ	denotes	downstream
T6328	7622-7624	IN	denotes	of
T6329	7625-7626	DT	denotes	a
T6330	7627-7634	NN	denotes	variety
T6331	7635-7637	IN	denotes	of
T6332	7638-7647	JJ	denotes	different
T6333	7648-7655	NNS	denotes	signals
T6334	7655-7656	,	denotes	,
T6335	7657-7666	VBG	denotes	including
T6336	7667-7681	JJ	denotes	mROS/oxidative
T6337	7682-7688	NN	denotes	stress
T6338	7688-7689	,	denotes	,
T6339	7690-7706	JJ	denotes	lysophosphatidic
T6340	7707-7711	NN	denotes	acid
T6341	7712-7715	CC	denotes	and
T6342	7716-7719	DT	denotes	the
T6343	7720-7727	NNP	denotes	Bcr-Abl
T6344	7728-7736	NN	denotes	oncogene
T6345	7737-7738	NNP	denotes	[
T6346	7738-7752	CD	denotes	17,21,23,30,37
T6347	7752-7753	NNP	denotes	]
T6348	7753-7754	.	denotes	.
T6349	7755-7766	RB	denotes	Furthermore
T6350	7766-7767	,	denotes	,
T6351	7768-7778	NN	denotes	expression
T6352	7779-7781	IN	denotes	of
T6353	7782-7784	DT	denotes	an
T6354	7785-7794	VBN	denotes	activated
T6355	7795-7799	NNP	denotes	PKD1
T6356	7800-7806	JJ	denotes	mutant
T6357	7807-7815	VBZ	denotes	enhances
T6358	7816-7829	JJ	denotes	HPK1-mediated
T6359	7830-7834	NNP	denotes	NFκB
T6360	7835-7845	NN	denotes	activation
T6361	7846-7847	NNP	denotes	[
T6362	7847-7849	CD	denotes	38
T6363	7849-7850	NNP	denotes	]
T6364	7850-7851	.	denotes	.
T6365	7852-7854	IN	denotes	In
T6366	7855-7856	NNP	denotes	B
T6367	7857-7862	NNS	denotes	cells
T6368	7862-7863	,	denotes	,
T6369	7864-7868	NNP	denotes	NFκB
T6370	7869-7871	VBZ	denotes	is
T6371	7872-7877	VBN	denotes	known
T6372	7878-7880	TO	denotes	to
T6373	7881-7883	VB	denotes	be
T6374	7884-7893	VBN	denotes	regulated
T6375	7894-7897	IN	denotes	via
T6376	7898-7901	NNP	denotes	DAG
T6377	7902-7905	CC	denotes	and
T6378	7906-7910	NNP	denotes	PKCβ
T6379	7911-7912	NNP	denotes	[
T6380	7912-7917	CD	denotes	39,40
T6381	7917-7918	NNP	denotes	]
T6382	7919-7922	CC	denotes	but
T6383	7923-7930	IN	denotes	whether
T6384	7931-7935	NNS	denotes	PKDs
T6385	7936-7939	VBP	denotes	are
T6386	7940-7943	JJ	denotes	key
T6387	7944-7958	NNS	denotes	intermediaries
T6388	7959-7962	IN	denotes	for
T6389	7963-7967	NNP	denotes	NFκB
T6390	7968-7978	NN	denotes	regulation
T6391	7979-7982	VBZ	denotes	has
T6392	7983-7986	RB	denotes	not
T6393	7987-7991	VBN	denotes	been
T6394	7992-8000	VBN	denotes	explored
T6395	8000-8001	.	denotes	.
T6396	8002-8005	DT	denotes	The
T6397	8006-8010	NNS	denotes	data
T6398	8011-8012	-LRB-	denotes	(
T6399	8012-8016	NNP	denotes	Fig.
T6400	8017-8019	NNP	denotes	4A
T6401	8019-8020	-RRB-	denotes	)
T6402	8021-8025	VBP	denotes	show
T6403	8026-8030	IN	denotes	that
T6404	8031-8035	NNP	denotes	NFκB
T6405	8036-8051	JJ	denotes	transcriptional
T6406	8052-8060	NN	denotes	activity
T6407	8061-8064	VBD	denotes	was
T6408	8065-8073	RB	denotes	strongly
T6409	8074-8081	VBN	denotes	induced
T6410	8082-8084	IN	denotes	in
T6411	8085-8089	DT	denotes	both
T6412	8090-8099	JJ	denotes	wild-type
T6413	8100-8103	CC	denotes	and
T6414	8104-8110	JJ	denotes	PKD1/3
T6415	8110-8111	NN	denotes	−
T6416	8111-8112	NN	denotes	/
T6417	8112-8113	NN	denotes	−
T6418	8114-8118	NNP	denotes	DT40
T6419	8119-8120	NNP	denotes	B
T6420	8121-8126	NNS	denotes	cells
T6421	8127-8129	IN	denotes	in
T6422	8130-8138	NN	denotes	response
T6423	8139-8141	TO	denotes	to
T6424	8142-8148	DT	denotes	either
T6425	8149-8156	NN	denotes	phorbol
T6426	8157-8162	NN	denotes	ester
T6427	8163-8165	CC	denotes	or
T6428	8166-8169	NNP	denotes	BCR
T6429	8170-8181	NN	denotes	stimulation
T6430	8181-8182	.	denotes	.
T6431	8183-8185	IN	denotes	In
T6432	8186-8194	NN	denotes	contrast
T6433	8194-8195	,	denotes	,
T6434	8196-8199	NNP	denotes	BCR
T6435	8200-8203	CC	denotes	and
T6436	8204-8211	JJ	denotes	phorbol
T6437	8212-8225	JJ	denotes	ester-induced
T6438	8226-8230	NNP	denotes	NFκB
T6439	8231-8246	JJ	denotes	transcriptional
T6440	8247-8255	NN	denotes	activity
T6441	8256-8259	VBD	denotes	was
T6442	8260-8269	VBN	denotes	abolished
T6443	8270-8272	IN	denotes	in
T6444	8273-8277	NNP	denotes	PKCβ
T6445	8277-8278	NNP	denotes	−
T6446	8278-8279	NNP	denotes	/
T6447	8279-8280	NNP	denotes	−
T6448	8281-8285	NNP	denotes	DT40
T6449	8286-8287	NNP	denotes	B
T6450	8288-8293	NNS	denotes	cells
T6451	8294-8295	-LRB-	denotes	(
T6452	8295-8299	NNP	denotes	Fig.
T6453	8300-8302	NNP	denotes	4A
T6454	8302-8303	-RRB-	denotes	)
T6455	8303-8304	,	denotes	,
T6456	8305-8313	IN	denotes	although
T6457	8314-8320	JJ	denotes	strong
T6458	8321-8331	NN	denotes	activation
T6459	8332-8334	IN	denotes	of
T6460	8335-8338	NNP	denotes	PKD
T6461	8339-8346	NNS	denotes	kinases
T6462	8347-8348	-LRB-	denotes	(
T6463	8348-8350	IN	denotes	as
T6464	8351-8359	VBN	denotes	assessed
T6465	8360-8362	IN	denotes	by
T6466	8363-8382	NN	denotes	autophosphorylation
T6467	8383-8385	IN	denotes	of
T6468	8386-8390	NNP	denotes	PKD1
T6469	8391-8393	IN	denotes	at
T6470	8394-8398	NNP	denotes	S916
T6471	8398-8399	-RRB-	denotes	)
T6472	8400-8403	VBD	denotes	was
T6473	8404-8412	VBN	denotes	observed
T6474	8413-8415	IN	denotes	in
T6475	8416-8419	DT	denotes	the
T6476	8420-8424	NNP	denotes	PKCβ
T6477	8424-8425	NNP	denotes	−
T6478	8425-8426	VBD	denotes	/
T6479	8426-8427	CD	denotes	−
T6480	8428-8433	NNS	denotes	cells
T6481	8434-8435	-LRB-	denotes	(
T6482	8435-8439	NNP	denotes	Fig.
T6483	8440-8442	NNP	denotes	4B
T6484	8442-8443	-RRB-	denotes	)
T6485	8443-8444	.	denotes	.
T6486	8445-8449	RB	denotes	Thus
T6487	8449-8450	,	denotes	,
T6488	8451-8454	NNP	denotes	PKD
T6489	8455-8462	NNS	denotes	kinases
T6490	8463-8466	VBP	denotes	are
T6491	8467-8474	DT	denotes	neither
T6492	8475-8484	JJ	denotes	essential
T6493	8485-8488	CC	denotes	nor
T6494	8489-8499	JJ	denotes	sufficient
T6495	8500-8502	TO	denotes	to
T6496	8503-8510	VB	denotes	mediate
T6497	8511-8522	JJ	denotes	BCR-induced
T6498	8523-8527	NN	denotes	NFκB
T6499	8528-8538	NN	denotes	activation
T6500	8539-8541	IN	denotes	in
T6501	8542-8546	NNP	denotes	DT40
T6502	8547-8548	NNP	denotes	B
T6503	8549-8554	NNS	denotes	cells
T6504	8555-8558	CC	denotes	and
T6505	8559-8564	RB	denotes	hence
T6506	8565-8567	VBP	denotes	do
T6507	8568-8571	RB	denotes	not
T6508	8572-8583	VB	denotes	participate
T6509	8584-8586	IN	denotes	in
T6510	8587-8594	NNP	denotes	DAG/PKC
T6511	8595-8603	VBD	denotes	mediated
T6512	8604-8611	NN	denotes	control
T6513	8612-8614	IN	denotes	of
T6514	8615-8619	NNP	denotes	NFκB
T6515	8619-8620	.	denotes	.
T4248	2489-2491	IN	denotes	in
T4249	2492-2493	NNP	denotes	[
T4250	2493-2495	CD	denotes	20
T4251	2495-2496	NNP	denotes	]
T4252	2496-2497	-RRB-	denotes	)
T4253	2497-2498	.	denotes	.
T4254	2499-2501	TO	denotes	To
T4255	2502-2513	VB	denotes	investigate
T4256	2514-2517	DT	denotes	the
T4257	2518-2524	NN	denotes	effect
T4258	2525-2529	WDT	denotes	that
T4259	2530-2534	NN	denotes	loss
T4260	2535-2537	IN	denotes	of
T4261	2538-2541	NNP	denotes	PKD
T4262	2542-2549	NNS	denotes	kinases
T4263	2550-2553	VBD	denotes	had
T4264	2554-2556	IN	denotes	on
T4265	2557-2558	NNP	denotes	B
T4266	2559-2563	NN	denotes	cell
T4267	2564-2572	NN	denotes	survival
T4268	2573-2579	CC	denotes	and/or
T4269	2580-2593	NN	denotes	proliferation
T4270	2594-2596	PRP	denotes	we
T4271	2597-2605	VBD	denotes	cultured
T4272	2606-2615	JJ	denotes	wild-type
T4273	2616-2619	CC	denotes	and
T4274	2620-2628	JJ	denotes	PKD-null
T4275	2629-2634	NNS	denotes	cells
R2280	T2731	T2744	nsubj	Loss,kinases
R2281	T2732	T2731	prep	of,Loss
R2282	T2733	T2734	compound	HSP27,phosphorylation
R2283	T2734	T2732	pobj	phosphorylation,of
R2284	T2735	T2731	prep	in,Loss
R2285	T2736	T2737	compound	DT40,B
R2286	T2737	T2738	compound	B,cells
R2287	T2738	T2735	pobj	cells,in
R2288	T2739	T2744	advcl	lacking,kinases
R2289	T2740	T2739	dobj	expression,lacking
R2290	T2741	T2740	prep	of,expression
R2291	T2742	T2743	compound	PKD,family
R2292	T2743	T2741	pobj	family,of
R2293	T2744	T2744	ROOT	kinases,kinases
R2294	T2745	T2746	compound	DT40,B
R2295	T2746	T2747	compound	B,cells
R2296	T2747	T2748	nsubj	cells,express
R2297	T2748	T2744	ccomp	express,kinases
R2298	T2749	T2751	nummod	two,isoforms
R2299	T2750	T2751	compound	PKD,isoforms
R2300	T2751	T2748	dobj	isoforms,express
R2301	T2752	T2751	punct	",",isoforms
R2302	T2753	T2751	conj	PKD1,isoforms
R2303	T2754	T2753	cc	and,PKD1
R2304	T2755	T2753	conj	PKD3,PKD1
R2305	T2756	T2755	punct	",",PKD3
R2306	T2757	T2748	cc	and,express
R2307	T2758	T2760	mark	as,described
R2308	T2759	T2760	advmod	previously,described
R2309	T2760	T2764	advcl	described,generated
R2310	T2761	T2764	nsubj	we,generated
R2311	T2762	T2764	aux	have,generated
R2312	T2763	T2764	advmod	recently,generated
R2313	T2764	T2748	conj	generated,express
R2314	T2765	T2768	compound	DT40,lines
R2315	T2766	T2768	compound	B,lines
R2316	T2767	T2768	compound	cell,lines
R2317	T2768	T2764	dobj	lines,generated
R2318	T2769	T2770	nsubj	that,lack
R2319	T2770	T2768	relcl	lack,lines
R2320	T2771	T2770	dobj	expression,lack
R2321	T2772	T2771	prep	of,expression
R2322	T2773	T2774	det	either,PKD1
R2323	T2774	T2772	pobj	PKD1,of
R2324	T2775	T2774	cc	or,PKD1
R2325	T2776	T2774	conj	PKD3,PKD1
R2326	T2777	T2776	cc	or,PKD3
R2327	T2778	T2779	det	both,enzymes
R2328	T2779	T2772	pobj	enzymes,of
R2329	T2780	T2782	nmod	[,]
R2330	T2781	T2782	nummod	1,]
R2331	T2782	T2764	npadvmod	],generated
R2332	T2783	T2744	punct	.,kinases
R2333	T2784	T2800	prep	In,/
R2334	T2785	T2784	pcomp	generating,In
R2335	T2786	T2790	det	the,lines
R2336	T2787	T2789	amod	double,cell
R2337	T2788	T2789	compound	knockout,cell
R2338	T2789	T2790	compound	cell,lines
R2339	T2790	T2785	dobj	lines,generating
R2340	T2791	T2792	nsubj	we,targeted
R2341	T2792	T2790	relcl	targeted,lines
R2342	T2793	T2795	det	the,loci
R2343	T2794	T2795	compound	PKD1,loci
R2344	T2795	T2792	dobj	loci,targeted
R2345	T2796	T2792	prep	in,targeted
R2346	T2797	T2799	det	a,−
R2347	T2798	T2799	compound	PKD3,−
R2348	T2799	T2796	pobj	−,in
R2349	T2800	T2800	ROOT	/,/
R2350	T2801	T2803	nummod	−,line
R2351	T2802	T2803	compound	cell,line
R2352	T2803	T2800	dobj	line,/
R2353	T2804	T2805	nsubj	that,expressed
R2354	T2805	T2803	relcl	expressed,line
R2355	T2806	T2808	det	a,transgene
R2356	T2807	T2808	amod	Flag-PKD3,transgene
R2357	T2808	T2805	dobj	transgene,expressed
R2358	T2809	T2808	prep	under,transgene
R2359	T2810	T2811	det	the,control
R2360	T2811	T2809	pobj	control,under
R2361	T2812	T2811	prep	of,control
R2362	T2813	T2815	det	a,promoter
R2363	T2814	T2815	amod	doxycycline-inducible,promoter
R2364	T2815	T2812	pobj	promoter,of
R2365	T2816	T2800	punct	.,/
R2366	T2817	T2832	advmod	Hence,is
R2367	T2818	T2832	punct	",",is
R2368	T2819	T2826	nmod	in,expression
R2369	T2820	T2821	det	the,presence
R2370	T2821	T2819	pobj	presence,in
R2371	T2822	T2821	prep	of,presence
R2372	T2823	T2822	pobj	doxycycline,of
R2373	T2824	T2821	punct	",",presence
R2374	T2825	T2826	compound	Flag-PKD3,expression
R2375	T2826	T2832	nsubj	expression,is
R2376	T2827	T2826	prep	in,expression
R2377	T2828	T2831	nummod	PKD1/3,cells
R2378	T2829	T2831	amod	double,cells
R2379	T2830	T2831	compound	knockout,cells
R2380	T2831	T2827	pobj	cells,in
R2381	T2832	T2832	ROOT	is,is
R2382	T2833	T2832	acomp	comparable,is
R2383	T2834	T2833	prep	to,comparable
R2384	T2835	T2837	amod	endogenous,present
R2385	T2836	T2837	amod	PKD3,present
R2386	T2837	T2834	pobj	present,to
R2387	T2838	T2837	prep	in,present
R2388	T2839	T2841	amod	wild-type,cells
R2389	T2840	T2841	compound	DT40,cells
R2390	T2841	T2838	pobj	cells,in
R2391	T2842	T2837	cc	and,present
R2392	T2843	T2837	conj	removal,present
R2393	T2844	T2843	prep	of,removal
R2394	T2845	T2844	pobj	doxycycline,of
R2395	T2846	T2843	prep	from,removal
R2396	T2847	T2849	det	the,media
R2397	T2848	T2849	compound	culture,media
R2398	T2849	T2846	pobj	media,from
R2399	T2850	T2832	prep	for,is
R2400	T2851	T2852	nummod	5,days
R2401	T2852	T2853	compound	days,results
R2402	T2853	T2850	pobj	results,for
R2403	T2854	T2853	prep	in,results
R2404	T2855	T2859	det	a,phenotype
R2405	T2856	T2857	advmod	completely,null
R2406	T2857	T2859	amod	null,phenotype
R2407	T2858	T2859	compound	PKD,phenotype
R2408	T2859	T2854	pobj	phenotype,in
R2409	T2860	T2862	punct	(,1A
R2410	T2861	T2862	compound	Fig.,1A
R2411	T2862	T2859	appos	1A,phenotype
R2412	T2863	T2862	punct	),1A
R2413	T2864	T2832	punct	.,is
R2414	T2865	T2869	advmod	Previously,demonstrated
R2415	T2866	T2869	punct	",",demonstrated
R2416	T2867	T2869	nsubj	we,demonstrated
R2417	T2868	T2869	aux	have,demonstrated
R2418	T2869	T2869	ROOT	demonstrated,demonstrated
R2419	T2870	T2886	mark	that,is
R2420	T2871	T2886	nsubj	phosphorylation,is
R2421	T2872	T2871	cc	and,phosphorylation
R2422	T2873	T2874	amod	nuclear,exclusion
R2423	T2874	T2871	conj	exclusion,phosphorylation
R2424	T2875	T2874	prep	of,exclusion
R2425	T2876	T2879	nmod	class,deacetylases
R2426	T2877	T2879	nmod	II,deacetylases
R2427	T2878	T2879	compound	histone,deacetylases
R2428	T2879	T2875	pobj	deacetylases,of
R2429	T2880	T2879	punct	(,deacetylases
R2430	T2881	T2879	appos	HDACs,deacetylases
R2431	T2882	T2879	punct	),deacetylases
R2432	T2883	T2871	prep	during,phosphorylation
R2433	T2884	T2885	compound	BCR,engagement
R2434	T2885	T2883	pobj	engagement,during
R2435	T2886	T2869	ccomp	is,demonstrated
R2436	T2887	T2886	acomp	defective,is
R2437	T2888	T2886	prep	in,is
R2438	T2889	T2894	nummod	PKD1/3,cells
R2439	T2890	T2894	nummod	−,cells
R2440	T2891	T2894	nmod	/,cells
R2441	T2892	T2894	compound	−,cells
R2442	T2893	T2894	compound	B,cells
R2443	T2894	T2888	pobj	cells,in
R2444	T2895	T2886	cc	and,is
R2445	T2896	T2897	aux	can,restored
R2446	T2897	T2886	conj	restored,is
R2451	T2902	T2904	amod	single,isoform
R2488	T2939	T2936	prep	on,phosphorylation
R2489	T2940	T2939	pobj	serine,on
R2490	T2941	T2940	nummod	82,serine
R2491	T2942	T2936	punct	",",phosphorylation
R2492	T2943	T2947	det	the,sequence
R2493	T2944	T2947	amod	proposed,sequence
R2494	T2945	T2946	compound	PKD1,substrate
R2495	T2946	T2947	compound	substrate,sequence
R2496	T2947	T2936	appos	sequence,phosphorylation
R2497	T2948	T2929	punct	.,assessed
R2498	T2949	T2951	nsubj	We,investigated
R2499	T2950	T2951	advmod	initially,investigated
R2500	T2951	T2951	ROOT	investigated,investigated
R2501	T2952	T2953	det	the,regulation
R2502	T2953	T2951	dobj	regulation,investigated
R2503	T2954	T2953	prep	of,regulation
R2504	T2955	T2956	compound	HSP27,phosphorylation
R2505	T2956	T2954	pobj	phosphorylation,of
R2506	T2957	T2956	prep	in,phosphorylation
R2507	T2958	T2959	amod	single,knockout
R2508	T2959	T2962	compound	knockout,cells
R2509	T2960	T2961	compound	DT40,B
R2510	T2961	T2962	compound	B,cells
R2511	T2962	T2957	pobj	cells,in
R2512	T2963	T2951	advcl	lacking,investigated
R2513	T2964	T2965	preconj	either,PKD1
R2514	T2965	T2963	dobj	PKD1,lacking
R2515	T2966	T2965	cc	or,PKD1
R2516	T2967	T2965	conj	PKD3,PKD1
R2517	T2968	T2951	punct	.,investigated
R2518	T2969	T2970	mark	As,shown
R2519	T2970	T2985	advcl	shown,increased
R2520	T2971	T2970	prep	in,shown
R2521	T2972	T2973	compound	Fig.,1B
R2522	T2973	T2971	pobj	1B,in
R2523	T2974	T2973	punct	",",1B
R2524	T2975	T2973	appos	activation,1B
R2525	T2976	T2975	prep	of,activation
R2526	T2977	T2978	det	the,BCR
R2527	T2978	T2976	pobj	BCR,of
R2528	T2979	T2975	cc	or,activation
R2529	T2980	T2975	conj	treatment,activation
R2530	T2981	T2975	prep	with,activation
R2531	T2982	T2984	det	the,PdBu
R2532	T2983	T2984	compound	DAG-mimetic,PdBu
R2533	T2984	T2981	pobj	PdBu,with
R2534	T2985	T2985	ROOT	increased,increased
R2535	T2986	T2987	det	the,levels
R2536	T2987	T2985	dobj	levels,increased
R2537	T2988	T2987	prep	of,levels
R2538	T2989	T2990	compound	HSP27,phosphorylation
R2539	T2990	T2988	pobj	phosphorylation,of
R2540	T2991	T2987	prep	at,levels
R2541	T2992	T2991	pobj	S82,at
R2542	T2993	T2992	prep	in,S82
R2543	T2994	T2997	amod	wild-type,cells
R2544	T2995	T2996	compound	DT40,B
R2545	T2996	T2997	compound	B,cells
R2546	T2997	T2993	pobj	cells,in
R2547	T2998	T2985	punct	.,increased
R2548	T2999	T3004	nsubj	BCR,were
R2549	T3000	T2999	cc	and,BCR
R2550	T3001	T3003	amod	phorbol,signals
R2551	T3002	T3003	compound	ester,signals
R2552	T3003	T2999	conj	signals,BCR
R2553	T3004	T3004	ROOT	were,were
R2554	T3005	T3004	advmod	also,were
R2555	T3006	T3004	acomp	able,were
R2556	T3007	T3008	aux	to,increase
R2557	T3008	T3006	xcomp	increase,able
R2558	T3009	T3010	compound	HSP27,phosphorylation
R2559	T3010	T3008	dobj	phosphorylation,increase
R2560	T3011	T3008	prep	in,increase
R2561	T3012	T3016	nummod	PKD1,knockout
R2562	T3013	T3012	cc	or,PKD1
R2563	T3014	T3012	conj	PKD3,PKD1
R2564	T3015	T3016	amod	single,knockout
R2565	T3016	T3019	compound	knockout,cells
R2566	T3017	T3018	compound	DT40,B
R2567	T3018	T3019	compound	B,cells
R2568	T3019	T3011	pobj	cells,in
R2569	T3020	T3004	punct	(,were
R2570	T3021	T3022	compound	Fig.,1B
R2571	T3022	T3004	npadvmod	1B,were
R2572	T3023	T3004	punct	),were
R2573	T3024	T3004	punct	.,were
R2574	T3025	T3038	advmod	However,abolished
R2575	T3026	T3038	punct	",",abolished
R2576	T3027	T3038	nsubjpass	BCR,abolished
R2577	T3028	T3027	punct	-,BCR
R2578	T3029	T3027	cc	and,BCR
R2579	T3030	T3032	nmod	phorbol,phosphorylation
R2580	T3031	T3032	amod	ester-induced,phosphorylation
R2581	T3032	T3027	conj	phosphorylation,BCR
R2582	T3033	T3032	prep	of,phosphorylation
R2583	T3034	T3033	pobj	HSP27,of
R2584	T3035	T3032	prep	on,phosphorylation
R2585	T3036	T3035	pobj	S82,on
R2586	T3037	T3038	auxpass	was,abolished
R2587	T3038	T3038	ROOT	abolished,abolished
R2588	T3039	T3038	prep	in,abolished
R2589	T3040	T3041	compound	B,cells
R2590	T3041	T3039	pobj	cells,in
R2591	T3042	T3043	nsubj	that,lacked
R2592	T3043	T3041	relcl	lacked,cells
R2593	T3044	T3045	preconj	both,PKD1
R2594	T3045	T3043	dobj	PKD1,lacked
R2595	T3046	T3045	cc	and,PKD1
R2596	T3047	T3045	conj	PKD3,PKD1
R2597	T3048	T3047	punct	(,PKD3
R2598	T3049	T3050	compound	Fig.,1C
R2599	T3050	T3047	appos	1C,PKD3
R2600	T3051	T3047	punct	),PKD3
R2601	T3052	T3038	punct	.,abolished
R2602	T3053	T3066	advmod	Significantly,was
R2603	T3054	T3056	punct	",",expression
R2604	T3055	T3056	amod	doxycycline-induced,expression
R2605	T3056	T3066	nsubj	expression,was
R2606	T3057	T3056	prep	of,expression
R2607	T3058	T3060	det	the,transgene
R2608	T3059	T3060	compound	Flag-PKD3,transgene
R2609	T3060	T3057	pobj	transgene,of
R2610	T3061	T3060	prep	in,transgene
R2611	T3062	T3065	det	the,cells
R2612	T3063	T3065	amod	double,cells
R2613	T3064	T3065	compound	knockout,cells
R2614	T3065	T3061	pobj	cells,in
R2615	T3066	T3066	ROOT	was,was
R2616	T3067	T3066	acomp	sufficient,was
R2617	T3068	T3069	aux	to,restore
R2618	T3069	T3067	xcomp	restore,sufficient
R2619	T3070	T3071	amod	normal,regulation
R2620	T3071	T3069	dobj	regulation,restore
R2621	T3072	T3071	prep	of,regulation
R2622	T3073	T3074	compound	HSP27,phosphorylation
R2623	T3074	T3072	pobj	phosphorylation,of
R2624	T3075	T3077	punct	(,1C
R2625	T3076	T3077	compound	Fig.,1C
R2626	T3077	T3074	appos	1C,phosphorylation
R2627	T3078	T3077	punct	),1C
R2628	T3079	T3066	punct	.,was
R2629	T3080	T3095	prep	In,was
R2630	T3081	T3080	pobj	contrast,In
R2631	T3082	T3095	punct	",",was
R2632	T3083	T3095	nsubj	expression,was
R2633	T3084	T3083	prep	of,expression
R2634	T3085	T3089	det	a,protein
R2635	T3086	T3089	amod	kinase-deficient,protein
R2636	T3087	T3089	amod	PKD3,protein
R2637	T3088	T3089	amod	mutant,protein
R2638	T3089	T3084	pobj	protein,of
R2639	T3090	T3089	prep	in,protein
R2640	T3091	T3094	det	the,cells
R2641	T3092	T3094	amod	double,cells
R2642	T3093	T3094	compound	knockout,cells
R2643	T3094	T3090	pobj	cells,in
R2644	T3095	T3095	ROOT	was,was
R2645	T3096	T3095	neg	not,was
R2646	T3097	T3095	acomp	able,was
R2647	T3098	T3099	aux	to,restore
R2648	T3099	T3097	xcomp	restore,able
R2649	T3100	T3099	dobj	BCR,restore
R2650	T3101	T3100	punct	-,BCR
R2651	T3102	T3099	cc	or,restore
R2652	T3103	T3099	conj	phorbol,restore
R2653	T3104	T3106	amod	ester-induced,phosphorylation
R2654	T3105	T3106	compound	HSP27,phosphorylation
R2655	T3106	T3103	dobj	phosphorylation,phorbol
R2656	T3107	T3106	punct	(,phosphorylation
R2657	T3108	T3109	compound	Fig.,1D
R2658	T3109	T3106	appos	1D,phosphorylation
R2659	T3110	T3106	punct	),phosphorylation
R2660	T3111	T3095	punct	.,was
R2661	T3112	T3120	advmod	Hence,regulate
R2662	T3113	T3120	punct	",",regulate
R2663	T3114	T3120	nsubj	PKD3,regulate
R2664	T3115	T3117	advmod	as,as
R2665	T3116	T3117	advmod	well,as
R2666	T3117	T3114	cc	as,PKD3
R2667	T3118	T3114	conj	PKD1,PKD3
R2668	T3119	T3120	aux	can,regulate
R2669	T3120	T3120	ROOT	regulate,regulate
R2670	T3121	T3122	compound	HSP27,phosphorylation
R2671	T3122	T3120	dobj	phosphorylation,regulate
R2672	T3123	T3120	cc	and,regulate
R2673	T3124	T3120	prep	in,regulate
R2674	T3125	T3126	compound	DT40,B
R2675	T3126	T3127	compound	B,cells
R2676	T3127	T3124	pobj	cells,in
R2677	T3128	T3129	nsubj	they,are
R2678	T3129	T3120	conj	are,regulate
R2679	T3130	T3131	advmod	functionally,redundant
R2680	T3131	T3129	acomp	redundant,are
R2681	T3132	T3131	prep	as,redundant
R2682	T3133	T3134	compound	HSP27,kinases
R2683	T3134	T3132	pobj	kinases,as
R2684	T3135	T3129	punct	.,are
R3417	T4218	T4219	compound	Cellular,proliferation
R3418	T4219	T4231	nsubj	proliferation,kinases
R3419	T4220	T4219	cc	and,proliferation
R3420	T4221	T4219	conj	survival,proliferation
R3421	T4222	T4219	prep	in,proliferation
R3422	T4223	T4224	compound	DT40,B
R3423	T4224	T4225	compound	B,cells
R3424	T4225	T4222	pobj	cells,in
R3425	T4226	T4231	advcl	lacking,kinases
R3426	T4227	T4226	dobj	expression,lacking
R3427	T4228	T4227	prep	of,expression
R3428	T4229	T4230	compound	PKD,family
R3429	T4230	T4228	pobj	family,of
R3430	T4231	T4231	ROOT	kinases,kinases
R3431	T4232	T4233	compound	PKD,enzymes
R3432	T4233	T4237	nsubjpass	enzymes,linked
R3433	T4234	T4237	aux	have,linked
R3434	T4235	T4237	advmod	previously,linked
R3435	T4236	T4237	auxpass	been,linked
R3436	T4237	T4231	ccomp	linked,kinases
R3437	T4238	T4237	prep	to,linked
R3438	T4239	T4240	det	the,regulation
R3439	T4240	T4238	pobj	regulation,to
R3440	T4241	T4240	prep	of,regulation
R3441	T4242	T4243	compound	cell,proliferation
R3442	T4243	T4241	pobj	proliferation,of
R3443	T4244	T4243	cc	and,proliferation
R3444	T4245	T4243	conj	survival,proliferation
R3445	T4246	T4243	punct	(,proliferation
R3446	T4247	T4240	acl	reviewed,regulation
R3447	T4248	T4247	prep	in,reviewed
R3448	T4249	T4248	pobj	[,in
R3449	T4250	T4251	nummod	20,]
R3450	T4251	T4249	appos	],[
R3451	T4252	T4249	punct	),[
R3452	T4253	T4231	punct	.,kinases
R3453	T4254	T4255	aux	To,investigate
R3454	T4255	T4271	advcl	investigate,cultured
R3455	T4256	T4257	det	the,effect
R3456	T4257	T4255	dobj	effect,investigate
R3457	T4258	T4263	dobj	that,had
R3458	T4259	T4263	nsubj	loss,had
R3459	T4260	T4259	prep	of,loss
R3460	T4261	T4262	compound	PKD,kinases
R3461	T4262	T4260	pobj	kinases,of
R3462	T4263	T4257	relcl	had,effect
R3463	T4264	T4263	prep	on,had
R3464	T4265	T4267	compound	B,survival
R3465	T4266	T4267	compound	cell,survival
R3466	T4267	T4264	pobj	survival,on
R3467	T4268	T4263	cc	and/or,had
R3468	T4269	T4271	dobj	proliferation,cultured
R3469	T4270	T4271	nsubj	we,cultured
R3470	T4271	T4271	ROOT	cultured,cultured
R3471	T4272	T4275	amod	wild-type,cells
R3472	T4273	T4272	cc	and,wild-type
R3473	T4274	T4272	conj	PKD-null,wild-type
R3474	T4275	T4271	dobj	cells,cultured
R3475	T4276	T4271	prep	in,cultured
R3476	T4277	T4278	det	the,presence
R3477	T4278	T4276	pobj	presence,in
R3478	T4279	T4278	punct	(,presence
R3479	T4280	T4300	nsubj	PKD1/3,monitored
R3480	T4281	T4283	nummod	−,−
R3481	T4282	T4283	compound	/,−
R3482	T4283	T4300	dep	−,monitored
R3483	T4284	T4283	punct	:,−
R3484	T4285	T4287	nmod	Flag-PKD3,ve
R3485	T4286	T4287	compound	+,ve
R3486	T4287	T4283	appos	ve,−
R3487	T4288	T4287	punct	),ve
R3488	T4289	T4287	cc	or,ve
R3489	T4290	T4287	conj	absence,ve
R3490	T4291	T4290	punct	(,absence
R3491	T4292	T4295	nummod	PKD1/3,−
R3492	T4293	T4295	nummod	−,−
R3493	T4294	T4295	compound	/,−
R3494	T4295	T4290	appos	−,absence
R3495	T4296	T4295	punct	),−
R3496	T4297	T4290	prep	of,absence
R3497	T4298	T4297	pobj	doxycycline,of
R3498	T4299	T4290	cc	and,absence
R3499	T4300	T4271	advcl	monitored,cultured
R3500	T4301	T4302	amod	exponential,growth
R3501	T4302	T4300	dobj	growth,monitored
R3502	T4303	T4271	punct	.,cultured
R3503	T4304	T4305	mark	As,shown
R3504	T4305	T4311	advcl	shown,−
R3505	T4306	T4305	prep	in,shown
R3506	T4307	T4308	compound	Fig.,2A
R3507	T4308	T4306	pobj	2A,in
R3508	T4309	T4311	punct	",",−
R3509	T4310	T4311	nsubj	PKD1/3,−
R3510	T4311	T4311	ROOT	−,−
R3511	T4312	T4314	nummod	/,cells
R3512	T4313	T4314	compound	−,cells
R3513	T4314	T4315	nsubj	cells,proliferated
R3514	T4315	T4311	ccomp	proliferated,−
R3515	T4316	T4315	advmod	exponentially,proliferated
R3516	T4317	T4315	cc	and,proliferated
R3517	T4318	T4324	nsubj	re-expression,had
R3518	T4319	T4318	prep	of,re-expression
R3519	T4320	T4319	pobj	Flag-PKD3,of
R3520	T4321	T4318	prep	in,re-expression
R3521	T4322	T4323	det	these,cells
R3522	T4323	T4321	pobj	cells,in
R3523	T4324	T4315	conj	had,proliferated
R3524	T4325	T4326	det	no,impact
R3525	T4326	T4324	dobj	impact,had
R3526	T4327	T4326	prep	on,impact
R3527	T4328	T4329	det	the,rate
R3528	T4329	T4327	pobj	rate,on
R3529	T4330	T4329	prep	of,rate
R3530	T4331	T4330	pobj	proliferation,of
R3531	T4332	T4311	punct	.,−
R3532	T4333	T4347	advmod	Furthermore,was
R3533	T4334	T4347	punct	",",was
R3534	T4335	T4336	det	the,viability
R3535	T4336	T4347	nsubj	viability,was
R3536	T4337	T4336	prep	of,viability
R3537	T4338	T4343	nummod	PKD1/3,cells
R3538	T4339	T4343	nummod	−,cells
R3539	T4340	T4343	compound	/,cells
R3540	T4341	T4343	compound	−,cells
R3541	T4342	T4343	compound	B,cells
R3542	T4343	T4337	pobj	cells,of
R3543	T4344	T4336	prep	during,viability
R3544	T4345	T4346	amod	routine,culturing
R3545	T4346	T4344	pobj	culturing,during
R3546	T4347	T4347	ROOT	was,was
R3547	T4348	T4347	neg	not,was
R3548	T4349	T4350	advmod	significantly,different
R3549	T4350	T4347	acomp	different,was
R3550	T4351	T4350	prep	from,different
R3551	T4352	T4351	pobj	that,from
R3552	T4353	T4352	prep	of,that
R3553	T4354	T4356	amod	wild-type,cells
R3554	T4355	T4356	compound	B,cells
R3555	T4356	T4353	pobj	cells,of
R3556	T4357	T4360	punct	(,shown
R3557	T4358	T4360	nsubjpass	data,shown
R3558	T4359	T4360	neg	not,shown
R3559	T4360	T4347	conj	shown,was
R3560	T4361	T4360	punct	),shown
R3561	T4362	T4347	punct	.,was
R3562	T4363	T4365	nsubjpass	It,noted
R3563	T4364	T4365	auxpass	was,noted
R3564	T4365	T4365	ROOT	noted,noted
R3565	T4366	T4377	mark	that,was
R3566	T4367	T4370	det	the,time
R3567	T4368	T4369	compound	population,doubling
R3568	T4369	T4370	amod	doubling,time
R3569	T4370	T4377	nsubj	time,was
R3570	T4371	T4370	prep	of,time
R3571	T4372	T4376	nummod	PKD1/3,cells
R3572	T4373	T4376	nummod	−,cells
R3573	T4374	T4376	compound	/,cells
R3574	T4375	T4376	compound	−,cells
R3575	T4376	T4371	pobj	cells,of
R3576	T4377	T4365	ccomp	was,noted
R3577	T4378	T4379	advmod	slightly,slower
R3578	T4379	T4377	acomp	slower,was
R3579	T4380	T4379	prep	than,slower
R3580	T4381	T4380	pobj	that,than
R3581	T4382	T4381	prep	of,that
R3582	T4383	T4384	amod	wild,type
R3583	T4384	T4382	pobj	type,of
R3584	T4385	T4386	nummod	DT40,cells
R3585	T4386	T4384	appos	cells,type
R3586	T4387	T4386	punct	(,cells
R3587	T4388	T4391	nummod	12.7,h
R3588	T4389	T4391	nmod	±,h
R3589	T4390	T4391	nummod	2.8,h
R3590	T4391	T4386	appos	h,cells
R3591	T4392	T4391	prep	versus,h
R3592	T4393	T4396	nummod	10.2,h
R3593	T4394	T4396	nmod	±,h
R3594	T4395	T4396	nummod	0.4,h
R3595	T4396	T4392	pobj	h,versus
R3596	T4397	T4386	punct	),cells
R3597	T4398	T4365	cc	but,noted
R3598	T4399	T4400	det	the,failure
R3599	T4400	T4415	nsubj	failure,suggests
R3600	T4401	T4400	prep	of,failure
R3601	T4402	T4403	nummod	PKD3,re-expression
R3602	T4403	T4401	pobj	re-expression,of
R3603	T4404	T4405	aux	to,modify
R3604	T4405	T4400	acl	modify,failure
R3605	T4406	T4408	det	the,rate
R3606	T4407	T4408	compound	proliferation,rate
R3607	T4408	T4405	dobj	rate,modify
R3608	T4409	T4408	prep	of,rate
R3609	T4410	T4414	nummod	PKD1/3,cells
R3610	T4411	T4414	nummod	−,cells
R3611	T4412	T4414	compound	/,cells
R3612	T4413	T4414	compound	−,cells
R3613	T4414	T4409	pobj	cells,of
R3614	T4415	T4365	conj	suggests,noted
R3615	T4416	T4420	mark	that,were
R3616	T4417	T4419	det	these,differences
R3617	T4418	T4419	amod	small,differences
R3618	T4419	T4420	nsubj	differences,were
R3619	T4420	T4415	ccomp	were,suggests
R3620	T4421	T4422	advmod	most,likely
R3621	T4422	T4420	acomp	likely,were
R3622	T4423	T4424	det	the,result
R3623	T4424	T4420	attr	result,were
R3624	T4425	T4424	prep	of,result
R3625	T4426	T4427	amod	clonal,variation
R3626	T4427	T4425	pobj	variation,of
R3627	T4428	T4420	cc	and,were
R3628	T4429	T4431	auxpass	were,caused
R3629	T4430	T4431	neg	not,caused
R3630	T4431	T4420	conj	caused,were
R3631	T4432	T4431	advmod	specifically,caused
R3632	T4433	T4431	agent	by,caused
R3633	T4434	T4433	pobj	loss,by
R3634	T4435	T4434	prep	of,loss
R3635	T4436	T4437	compound	PKD,enzymes
R3636	T4437	T4435	pobj	enzymes,of
R3637	T4438	T4415	punct	.,suggests
R3638	T4439	T4444	advmod	Thus,are
R3639	T4440	T4444	punct	",",are
R3640	T4441	T4443	compound	PKD,enzymes
R3641	T4442	T4443	compound	family,enzymes
R3642	T4443	T4444	nsubj	enzymes,are
R3643	T4444	T4444	ROOT	are,are
R3644	T4445	T4444	neg	not,are
R3645	T4446	T4444	acomp	essential,are
R3646	T4447	T4446	prep	for,essential
R3647	T4448	T4447	pcomp	regulating,for
R3648	T4449	T4450	amod	basal,survival
R3649	T4450	T4448	dobj	survival,regulating
R3650	T4451	T4450	cc	and,survival
R3658	T4459	T4469	nsubj	enzymes,linked
R3659	T4460	T4459	punct	",",enzymes
R3660	T4461	T4462	advmod	specifically,PKD1
R3661	T4462	T4459	appos	PKD1,enzymes
R3662	T4463	T4462	cc	and,PKD1
R3663	T4464	T4462	conj	PKD2,PKD1
R3664	T4465	T4469	punct	",",linked
R3665	T4466	T4469	aux	have,linked
R3666	T4467	T4469	advmod	previously,linked
R3667	T4468	T4469	auxpass	been,linked
R3668	T4469	T4469	ROOT	linked,linked
R3669	T4470	T4469	prep	to,linked
R3670	T4471	T4473	det	a,role
R3671	T4472	T4473	amod	protective,role
R3672	T4473	T4470	pobj	role,to
R3673	T4474	T4473	prep	against,role
R3674	T4475	T4477	amod	oxidative,injury
R3675	T4476	T4477	amod	stress-induced,injury
R3676	T4477	T4486	nmod	injury,lines
R3677	T4478	T4477	prep	in,injury
R3678	T4479	T4480	compound	3T3,fibroblast
R3679	T4480	T4478	pobj	fibroblast,in
R3680	T4481	T4480	punct	",",fibroblast
R3681	T4482	T4480	conj	HeLa,fibroblast
R3682	T4483	T4482	cc	and,HeLa
R3683	T4484	T4486	amod	epithelial,lines
R3684	T4485	T4486	compound	cell,lines
R3685	T4486	T4474	pobj	lines,against
R3686	T4487	T4488	compound	[,"17,30"
R3687	T4488	T4486	appos	"17,30",lines
R3688	T4489	T4490	nummod	32,]
R3689	T4490	T4486	appos	],lines
R3690	T4491	T4469	punct	.,linked
R3691	T4492	T4494	nsubj	We,addressed
R3692	T4493	T4494	advmod	therefore,addressed
R3693	T4494	T4494	ROOT	addressed,addressed
R3694	T4495	T4496	det	the,role
R3695	T4496	T4494	dobj	role,addressed
R3696	T4497	T4496	prep	of,role
R3697	T4498	T4499	compound	PKD,family
R3698	T4499	T4500	compound	family,kinases
R3699	T4500	T4497	pobj	kinases,of
R3700	T4501	T4496	prep	in,role
R3701	T4502	T4501	pcomp	regulating,in
R3702	T4503	T4504	compound	B,cell
R3703	T4504	T4505	compound	cell,survival
R3704	T4505	T4502	dobj	survival,regulating
R3705	T4506	T4502	prep	in,regulating
R3706	T4507	T4506	pobj	response,in
R3707	T4508	T4507	prep	to,response
R3708	T4509	T4510	amod	oxidative,stress
R3709	T4510	T4508	pobj	stress,to
R3710	T4511	T4510	cc	and,stress
R3711	T4512	T4514	amod	other,stimuli
R3712	T4513	T4514	compound	stress,stimuli
R3713	T4514	T4510	conj	stimuli,stress
R3714	T4515	T4494	punct	.,addressed
R3715	T4516	T4517	mark	As,shown
R3716	T4517	T4526	advcl	shown,had
R3717	T4518	T4517	prep	in,shown
R3718	T4519	T4520	compound	Fig.,2B
R3719	T4520	T4518	pobj	2B,in
R3720	T4521	T4520	punct	",",2B
R3721	T4522	T4520	appos	loss,2B
R3722	T4523	T4522	prep	of,loss
R3723	T4524	T4525	nummod	PKD1/3,expression
R3724	T4525	T4523	pobj	expression,of
R3725	T4526	T4526	ROOT	had,had
R3726	T4527	T4529	det	no,impact
R3727	T4528	T4529	amod	significant,impact
R3728	T4529	T4526	dobj	impact,had
R3729	T4530	T4529	prep	on,impact
R3730	T4531	T4532	det	the,survival
R3731	T4532	T4530	pobj	survival,on
R3732	T4533	T4532	prep	of,survival
R3733	T4534	T4535	compound	DT40,B
R3734	T4535	T4536	compound	B,cells
R3735	T4536	T4533	pobj	cells,of
R3736	T4537	T4526	prep	in,had
R3737	T4538	T4537	pobj	response,in
R3738	T4539	T4538	prep	to,response
R3739	T4540	T4542	amod	mitochondrial,stimuli
R3740	T4541	T4542	compound	stress,stimuli
R3741	T4542	T4539	pobj	stimuli,to
R3742	T4543	T4542	punct	(,stimuli
R3743	T4544	T4542	appos	H2O2,stimuli
R3744	T4545	T4544	cc	or,H2O2
R3745	T4546	T4547	compound	serum,deprivation
R3746	T4547	T4544	conj	deprivation,H2O2
R3747	T4548	T4542	punct	),stimuli
R3748	T4549	T4542	punct	;,stimuli
R3749	T4550	T4552	amod	DNA,agents
R3750	T4551	T4552	amod	damaging,agents
R3751	T4552	T4542	conj	agents,stimuli
R3752	T4553	T4552	punct	(,agents
R3753	T4554	T4552	appos	etoposide,agents
R3754	T4555	T4554	cc	or,etoposide
R3755	T4556	T4554	conj	doxorubicin,etoposide
R3756	T4557	T4552	punct	),agents
R3757	T4558	T4526	punct	;,had
R3758	T4559	T4561	compound	ER,stress
R3759	T4560	T4561	compound	pathway,stress
R3760	T4561	T4570	nsubj	stress,following
R3761	T4562	T4561	amod	due,stress
R3762	T4563	T4562	pcomp	to,due
R3763	T4564	T4565	compound	calcium,overload
R3764	T4565	T4562	pobj	overload,due
R3765	T4566	T4567	punct	(,thapsigargin
R3766	T4567	T4565	appos	thapsigargin,overload
R3767	T4568	T4567	punct	),thapsigargin
R3768	T4569	T4565	cc	or,overload
R3769	T4570	T4526	advcl	following,had
R3770	T4571	T4572	amod	prolonged,treatment
R3771	T4572	T4570	dobj	treatment,following
R3772	T4573	T4572	prep	with,treatment
R3773	T4574	T4575	compound	phorbol,esters
R3774	T4575	T4573	pobj	esters,with
R3775	T4576	T4575	cc	or,esters
R3776	T4577	T4578	compound	Trichostatin,A
R3777	T4578	T4575	conj	A,esters
R3778	T4579	T4578	punct	",",A
R3779	T4580	T4581	det	an,inhibitor
R3780	T4581	T4578	appos	inhibitor,A
R3781	T4582	T4581	prep	of,inhibitor
R3782	T4583	T4585	compound	class,HDACs
R3783	T4584	T4585	compound	I/II,HDACs
R3784	T4585	T4582	pobj	HDACs,of
R3785	T4586	T4526	punct	.,had
R3786	T4587	T4593	advmod	Thus,play
R3787	T4588	T4593	punct	",",play
R3788	T4589	T4590	compound	PKD,kinases
R3789	T4590	T4593	nsubj	kinases,play
R3790	T4591	T4593	aux	do,play
R3791	T4592	T4593	neg	not,play
R3792	T4593	T4593	ROOT	play,play
R3793	T4594	T4596	det	an,role
R3794	T4595	T4596	amod	essential,role
R3795	T4596	T4593	dobj	role,play
R3796	T4597	T4593	prep	in,play
R3797	T4598	T4597	pcomp	regulating,in
R3798	T4599	T4600	compound	B,cell
R3799	T4600	T4601	compound	cell,survival
R3800	T4601	T4598	dobj	survival,regulating
R3801	T4602	T4598	prep	in,regulating
R3802	T4603	T4602	pobj	response,in
R3803	T4604	T4603	prep	to,response
R3804	T4605	T4606	det	a,range
R3805	T4606	T4604	pobj	range,to
R3806	T4607	T4606	prep	of,range
R3807	T4608	T4610	amod	different,stimuli
R3808	T4609	T4610	compound	stress,stimuli
R3809	T4610	T4607	pobj	stimuli,of
R3810	T4611	T4593	punct	.,play
R4622	T5769	T5770	compound	Antigen,receptor
R4623	T5770	T5773	amod	receptor,pathways
R4624	T5771	T5773	amod	regulated,pathways
R4625	T5772	T5773	amod	signalling,pathways
R4626	T5773	T5781	nsubj	pathways,explore
R4627	T5774	T5773	prep	in,pathways
R4628	T5775	T5777	compound	PKD-null,B
R4629	T5776	T5777	compound	DT40,B
R4630	T5777	T5778	compound	B,cells
R4631	T5778	T5774	pobj	cells,in
R4632	T5779	T5781	aux	To,explore
R4633	T5780	T5781	advmod	further,explore
R4634	T5781	T5781	ROOT	explore,explore
R4635	T5782	T5783	det	the,contribution
R4636	T5783	T5781	dobj	contribution,explore
R4637	T5784	T5783	prep	of,contribution
R4638	T5785	T5786	compound	PKD,kinases
R4639	T5786	T5784	pobj	kinases,of
R4640	T5787	T5786	prep	to,kinases
R4641	T5788	T5791	compound	DT40,biology
R4642	T5789	T5791	compound	B,biology
R4643	T5790	T5791	compound	cell,biology
R4644	T5791	T5787	pobj	biology,to
R4645	T5792	T5793	nsubj	we,investigated
R4646	T5793	T5783	relcl	investigated,contribution
R4647	T5794	T5799	mark	whether,were
R4648	T5795	T5798	amod	specific,events
R4649	T5796	T5798	amod	BCR-regulated,events
R4650	T5797	T5798	amod	signalling,events
R4651	T5798	T5799	nsubj	events,were
R4652	T5799	T5793	ccomp	were,investigated
R4653	T5800	T5799	acomp	defective,were
R4654	T5801	T5800	prep	in,defective
R4655	T5802	T5805	det	the,cells
R4656	T5803	T5804	compound	PKD-null,B
R4657	T5804	T5805	compound	B,cells
R4658	T5805	T5801	pobj	cells,in
R4659	T5806	T5781	punct	.,explore
R4660	T5807	T5808	amod	Initial,experiments
R4661	T5808	T5809	nsubj	experiments,revealed
R4662	T5809	T5809	ROOT	revealed,revealed
R4663	T5810	T5817	mark	that,reduced
R4664	T5811	T5812	compound	surface,expression
R4665	T5812	T5817	nsubjpass	expression,reduced
R4666	T5813	T5812	prep	of,expression
R4667	T5814	T5815	det	the,BCR
R4668	T5815	T5813	pobj	BCR,of
R4669	T5816	T5817	auxpass	was,reduced
R4670	T5817	T5809	ccomp	reduced,revealed
R4671	T5818	T5817	prep	in,reduced
R4672	T5819	T5822	nummod	PKD1/3,−
R4673	T5820	T5822	nummod	−,−
R4674	T5821	T5822	compound	/,−
R4675	T5822	T5818	pobj	−,in
R4676	T5823	T5822	punct	(,−
R4677	T5824	T5818	cc	and,in
R4678	T5825	T5817	prep	in,reduced
R4679	T5826	T5835	nummod	PKD1/3,cells
R4680	T5827	T5829	nummod	−,−
R4681	T5828	T5829	compound	/,−
R4682	T5829	T5835	nummod	−,cells
R4683	T5830	T5829	punct	:,−
R4684	T5831	T5829	appos	Flag-PKD3,−
R4685	T5832	T5833	advmod	+,ve
R4686	T5833	T5829	appos	ve,−
R4687	T5834	T5829	punct	),−
R4688	T5835	T5825	pobj	cells,in
R4689	T5836	T5817	prep	compared,reduced
R4690	T5837	T5836	prep	to,compared
R4691	T5838	T5841	amod	wild-type,cells
R4692	T5839	T5840	compound	DT40,B
R4693	T5840	T5841	compound	B,cells
R4694	T5841	T5837	pobj	cells,to
R4695	T5842	T5841	punct	(,cells
R4696	T5843	T5844	compound	Fig.,3A
R4697	T5844	T5841	appos	3A,cells
R4698	T5845	T5844	cc	and,3A
R4699	T5846	T5848	nsubj	data,shown
R4700	T5847	T5848	neg	not,shown
R4701	T5848	T5841	relcl	shown,cells
R4702	T5849	T5817	punct	),reduced
R4703	T5850	T5809	punct	.,revealed
R4704	T5851	T5860	advmod	Nevertheless,was
R4705	T5852	T5860	punct	",",was
R4706	T5853	T5860	nsubj	BCR-crosslinking,was
R4707	T5854	T5853	prep	of,BCR-crosslinking
R4708	T5855	T5859	nummod	PKD1/3,cells
R4709	T5856	T5859	nummod	−,cells
R4710	T5857	T5859	nmod	/,cells
R4711	T5858	T5859	amod	−,cells
R4712	T5859	T5854	pobj	cells,of
R4713	T5860	T5860	ROOT	was,was
R4714	T5861	T5860	acomp	sufficient,was
R4715	T5862	T5863	aux	to,induce
R4716	T5863	T5861	xcomp	induce,sufficient
R4717	T5864	T5865	det	the,activation
R4718	T5865	T5863	dobj	activation,induce
R4719	T5866	T5865	prep	of,activation
R4720	T5867	T5868	det	a,number
R4721	T5868	T5866	pobj	number,of
R4722	T5869	T5868	prep	of,number
R4723	T5870	T5869	pcomp	signalling,of
R4724	T5871	T5870	dobj	cascades,signalling
R4725	T5872	T5871	punct	",",cascades
R4726	T5873	T5871	amod	similar,cascades
R4727	T5874	T5873	prep	to,similar
R4728	T5875	T5876	nsubj	that,observed
R4729	T5876	T5871	relcl	observed,cascades
R4730	T5877	T5876	prep	in,observed
R4731	T5878	T5879	amod	wild-type,cells
R4732	T5879	T5877	pobj	cells,in
R4733	T5880	T5871	punct	(,cascades
R4734	T5881	T5882	compound	Fig.,3B
R4735	T5882	T5871	appos	3B,cascades
R4736	T5883	T5871	punct	),cascades
R4737	T5884	T5860	punct	.,was
R4738	T5885	T5888	advmod	Hence,activation
R4739	T5886	T5888	punct	",",activation
R4740	T5887	T5888	amod	BCR-induced,activation
R4741	T5888	T5909	nsubj	activation,was
R4742	T5889	T5888	prep	of,activation
R4743	T5890	T5891	det	the,Akt
R4744	T5891	T5889	pobj	Akt,of
R4745	T5892	T5891	punct	",",Akt
R4746	T5893	T5895	compound	mTOR/p70,kinase
R4747	T5894	T5895	compound	S6,kinase
R4748	T5895	T5891	appos	kinase,Akt
R4749	T5896	T5898	punct	(,shown
R4750	T5897	T5898	mark	as,shown
R4751	T5898	T5888	advcl	shown,activation
R4752	T5899	T5898	agent	by,shown
R4753	T5900	T5908	nummod	S6,pathways
R4754	T5901	T5902	amod	ribosomal,protein
R4755	T5902	T5908	nmod	protein,pathways
R4756	T5903	T5902	appos	phosphorylation,protein
R4757	T5904	T5902	punct	),protein
R4758	T5905	T5902	cc	and,protein
R4759	T5906	T5902	conj	MAPK,protein
R4760	T5907	T5908	amod	signalling,pathways
R4761	T5908	T5899	pobj	pathways,by
R4762	T5909	T5909	ROOT	was,was
R4763	T5910	T5909	advmod	clearly,was
R4764	T5911	T5909	acomp	detectable,was
R4765	T5912	T5911	prep	in,detectable
R4766	T5913	T5914	compound	PKD1/3-null,B
R4767	T5914	T5915	compound	B,cells
R4768	T5915	T5912	pobj	cells,in
R4769	T5916	T5918	punct	(,3B
R4770	T5917	T5918	compound	Fig.,3B
R4771	T5918	T5911	appos	3B,detectable
R4772	T5919	T5918	punct	),3B
R4773	T5920	T5909	punct	.,was
R4774	T5921	T5941	advmod	Furthermore,observed
R4775	T5922	T5941	punct	",",observed
R4776	T5923	T5925	amod	enhanced,phosphorylation
R4777	T5924	T5925	compound	tyrosine,phosphorylation
R4778	T5925	T5941	nsubjpass	phosphorylation,observed
R4779	T5926	T5925	prep	of,phosphorylation
R4780	T5927	T5929	amod	multiple,proteins
R4781	T5928	T5929	amod	cellular,proteins
R4782	T5929	T5926	pobj	proteins,of
R4783	T5930	T5932	advmod	as,as
R4784	T5931	T5932	advmod	well,as
R4785	T5932	T5925	cc	as,phosphorylation
R4786	T5933	T5934	det	an,increase
R4787	T5934	T5925	conj	increase,phosphorylation
R4788	T5935	T5934	prep	in,increase
R4789	T5936	T5938	amod	intracellular,levels
R4790	T5937	T5938	compound	calcium,levels
R4791	T5938	T5935	pobj	levels,in
R4792	T5939	T5941	auxpass	was,observed
R4793	T5940	T5941	advmod	also,observed
R4794	T5941	T5941	ROOT	observed,observed
R4795	T5942	T5941	prep	following,observed
R4796	T5943	T5944	compound	BCR,stimulation
R4797	T5944	T5942	pobj	stimulation,following
R4798	T5945	T5944	prep	of,stimulation
R4799	T5946	T5948	nmod	PKD1/3-null,cells
R4800	T5947	T5948	compound	B,cells
R4801	T5948	T5945	pobj	cells,of
R4802	T5949	T5950	punct	(,data
R4803	T5950	T5948	appos	data,cells
R4804	T5951	T5952	neg	not,shown
R4805	T5952	T5950	acl	shown,data
R4806	T5953	T5950	punct	),data
R4807	T5954	T5941	punct	.,observed
R4808	T5955	T5957	nsubj	We,observe
R4809	T5956	T5957	aux	did,observe
R4810	T5957	T5957	ROOT	observe,observe
R4811	T5958	T5970	mark	that,induced
R4812	T5959	T5960	det	the,strength
R4813	T5960	T5970	nsubj	strength,induced
R4814	T5961	T5960	prep	of,strength
R4815	T5962	T5961	pobj	BCR,of
R4816	T5963	T5960	punct	(,strength
R4817	T5964	T5960	cc	but,strength
R4818	T5965	T5966	neg	not,phorbol
R4819	T5966	T5967	advmod	phorbol,ester
R4820	T5967	T5960	conj	ester,strength
R4821	T5968	T5960	punct	),strength
R4822	T5969	T5970	punct	-,induced
R4823	T5970	T5957	ccomp	induced,observe
R4824	T5971	T5970	dobj	regulation,induced
R4825	T5972	T5971	prep	of,regulation
R4826	T5973	T5976	det	the,pathway
R4827	T5974	T5976	amod	Erk1-RSK1,pathway
R4828	T5975	T5976	compound	signalling,pathway
R4829	T5976	T5972	pobj	pathway,of
R4830	T5977	T5978	auxpass	was,reduced
R4831	T5978	T5970	conj	reduced,induced
R4832	T5979	T5978	prep	in,reduced
R4833	T5980	T5985	nummod	PKD1/3,cells
R4834	T5981	T5985	nummod	−,cells
R4835	T5982	T5985	compound	/,cells
R4836	T5983	T5985	compound	−,cells
R4837	T5984	T5985	compound	B,cells
R4838	T5985	T5979	pobj	cells,in
R4839	T5986	T5978	prep	compared,reduced
R4840	T5987	T5986	prep	to,compared
R4841	T5988	T5990	amod	wild-type,cells
R4842	T5989	T5990	compound	B,cells
R4843	T5990	T5987	pobj	cells,to
R4844	T5991	T5993	punct	(,3B
R4845	T5992	T5993	compound	Fig.,3B
R4846	T5993	T5990	appos	3B,cells
R4847	T5994	T5990	punct	),cells
R4848	T5995	T5957	punct	.,observe
R4849	T5996	T5997	nummod	One,interpretation
R4854	T6001	T6001	ROOT	is,is
R4855	T6002	T6006	mark	that,modulate
R4856	T6003	T6004	compound	PKD,enzymes
R4857	T6004	T6006	nsubj	enzymes,modulate
R4858	T6005	T6006	aux	may,modulate
R4859	T6006	T6001	ccomp	modulate,is
R4860	T6007	T6008	compound	Erk,activation
R4861	T6008	T6006	dobj	activation,modulate
R4862	T6009	T6001	punct	.,is
R4863	T6010	T6017	advmod	Indeed,linked
R4864	T6011	T6017	punct	",",linked
R4865	T6012	T6013	compound	PKD,enzymes
R4866	T6013	T6017	nsubj	enzymes,linked
R4867	T6014	T6017	aux	have,linked
R4868	T6015	T6017	advmod	previously,linked
R4869	T6016	T6017	auxpass	been,linked
R4870	T6017	T6017	ROOT	linked,linked
R4871	T6018	T6017	prep	to,linked
R4872	T6019	T6020	det	the,growth
R4873	T6020	T6018	pobj	growth,to
R4874	T6021	T6023	amod	factor-regulated,signalling
R4875	T6022	T6023	compound	Erk,signalling
R4876	T6023	T6017	dobj	signalling,linked
R4877	T6024	T6023	prep	in,signalling
R4878	T6025	T6029	nmod	fibroblast,lines
R4879	T6026	T6025	cc	and,fibroblast
R4880	T6027	T6029	amod	endothelial,lines
R4881	T6028	T6029	compound	cell,lines
R4882	T6029	T6024	pobj	lines,in
R4883	T6030	T6023	dobj	[,signalling
R4884	T6031	T6030	nummod	33,[
R4885	T6032	T6033	nummod	35,]
R4886	T6033	T6030	appos	],[
R4887	T6034	T6017	punct	.,linked
R4888	T6035	T6042	advmod	However,reduced
R4889	T6036	T6042	punct	",",reduced
R4890	T6037	T6039	amod	BCR-induced,phosphorylation
R4891	T6038	T6039	compound	Erk,phosphorylation
R4892	T6039	T6042	nsubjpass	phosphorylation,reduced
R4893	T6040	T6042	auxpass	was,reduced
R4894	T6041	T6042	advmod	also,reduced
R4895	T6042	T6042	ROOT	reduced,reduced
R4896	T6043	T6042	prep	in,reduced
R4897	T6044	T6052	nummod	PKD1/3,cells
R4898	T6045	T6046	nummod	−,/
R4899	T6046	T6052	compound	/,cells
R4900	T6047	T6049	punct	−,Flag-PKD3
R4901	T6048	T6049	punct	-,Flag-PKD3
R4902	T6049	T6052	compound	Flag-PKD3,cells
R4903	T6050	T6052	compound	+,cells
R4904	T6051	T6052	compound	B,cells
R4905	T6052	T6043	pobj	cells,in
R4906	T6053	T6052	punct	(,cells
R4907	T6054	T6054	ROOT	data,data
R4908	T6055	T6056	neg	not,shown
R4909	T6056	T6054	acl	shown,data
R4910	T6057	T6054	punct	),data
R4911	T6058	T6042	advcl	suggesting,reduced
R4912	T6059	T6074	mark	that,−
R4913	T6060	T6062	amod	reduced,levels
R4914	T6061	T6062	compound	BCR,levels
R4915	T6062	T6074	nsubj	levels,−
R4916	T6063	T6062	prep	on,levels
R4917	T6064	T6065	det	the,surface
R4918	T6065	T6063	pobj	surface,on
R4919	T6066	T6065	prep	of,surface
R4920	T6067	T6070	nummod	PKD1/3,−
R4921	T6068	T6070	nummod	−,−
R4922	T6069	T6070	compound	/,−
R4923	T6070	T6066	pobj	−,of
R4924	T6071	T6070	punct	(,−
R4925	T6072	T6070	cc	and,−
R4926	T6073	T6074	nsubj	PKD1/3,−
R4927	T6074	T6058	ccomp	−,suggesting
R4928	T6075	T6079	nummod	/,+
R4929	T6076	T6078	punct	−,Flag-PKD3
R4930	T6077	T6078	punct	-,Flag-PKD3
R4939	T6086	T6085	prep	on,impact
R4940	T6087	T6088	det	the,strength
R4941	T6088	T6086	pobj	strength,on
R4942	T6089	T6088	prep	of,strength
R4943	T6090	T6089	pobj	activation,of
R4944	T6091	T6090	prep	of,activation
R4945	T6092	T6096	det	this,pathway
R4946	T6093	T6096	amod	specific,pathway
R4947	T6094	T6096	amod	intracellular,pathway
R4948	T6095	T6096	compound	signalling,pathway
R4949	T6096	T6091	pobj	pathway,of
R4950	T6097	T6085	punct	.,impact
R4951	T6098	T6099	aux	To,search
R4952	T6099	T6120	advcl	search,used
R4953	T6100	T6099	prep	for,search
R4954	T6101	T6104	amod	other,targets
R4955	T6102	T6104	amod	potential,targets
R4956	T6103	T6104	compound	PKD,targets
R4957	T6104	T6100	pobj	targets,for
R4958	T6105	T6107	nsubj	that,show
R4959	T6106	T6107	aux	may,show
R4960	T6107	T6104	relcl	show,targets
R4961	T6108	T6109	amod	defective,regulation
R4962	T6109	T6107	dobj	regulation,show
R4963	T6110	T6109	prep	in,regulation
R4964	T6111	T6116	compound	PKD1/3,B
R4965	T6112	T6116	compound	−,B
R4966	T6113	T6116	compound	/,B
R4967	T6114	T6116	compound	−,B
R4968	T6115	T6116	compound	DT40,B
R4969	T6116	T6117	compound	B,cells
R4970	T6117	T6110	pobj	cells,in
R4971	T6118	T6120	punct	",",used
R4972	T6119	T6120	nsubj	we,used
R4973	T6120	T6120	ROOT	used,used
R4974	T6121	T6123	det	a,substrate
R4975	T6122	T6123	compound	PKD,substrate
R4976	T6123	T6120	dobj	substrate,used
R4977	T6124	T6123	amod	phospho-antibody,substrate
R4978	T6125	T6126	nsubj	that,recognises
R4979	T6126	T6124	relcl	recognises,phospho-antibody
R4980	T6127	T6129	compound	consensus,sequences
R4981	T6128	T6129	compound	phosphorylation,sequences
R4982	T6129	T6126	dobj	sequences,recognises
R4983	T6130	T6129	acl	targeted,sequences
R4984	T6131	T6130	agent	by,targeted
R4985	T6132	T6133	compound	PKD,enzymes
R4986	T6133	T6131	pobj	enzymes,by
R4987	T6134	T6137	punct	(,[
R4988	T6135	T6137	nmod	LxRxxpS/T,[
R4989	T6136	T6137	punct	),[
R4990	T6137	T6133	appos	[,enzymes
R4991	T6138	T6139	nummod	36,]
R4992	T6139	T6137	appos	],[
R4993	T6140	T6120	punct	.,used
R4994	T6141	T6142	mark	As,shown
R4995	T6142	T6160	advcl	shown,was
R4996	T6143	T6142	prep	in,shown
R4997	T6144	T6145	compound	Fig.,3C
R4998	T6145	T6143	pobj	3C,in
R4999	T6146	T6145	punct	",",3C
R5000	T6147	T6160	nsubj	phorbol,was
R5001	T6148	T6160	nsubj	ester,was
R5002	T6149	T6148	punct	-,ester
R5003	T6150	T6148	cc	and,ester
R5004	T6151	T6152	amod	BCR-induced,phosphorylation
R5005	T6152	T6148	conj	phosphorylation,ester
R5006	T6153	T6152	prep	of,phosphorylation
R5007	T6154	T6155	amod	cellular,substrates
R5008	T6155	T6153	pobj	substrates,of
R5009	T6156	T6155	acl	detected,substrates
R5010	T6157	T6156	agent	by,detected
R5011	T6158	T6159	det	this,phospho-antibody
R5012	T6159	T6157	pobj	phospho-antibody,by
R5013	T6160	T6160	ROOT	was,was
R5014	T6161	T6160	acomp	similar,was
R5015	T6162	T6161	prep	in,similar
R5016	T6163	T6169	amod	wild-type,cells
R5017	T6164	T6163	cc	and,wild-type
R5018	T6165	T6163	conj	PKD1/3,wild-type
R5019	T6166	T6169	compound	−,cells
R5020	T6167	T6169	compound	/,cells
R5021	T6168	T6169	compound	−,cells
R5022	T6169	T6162	pobj	cells,in
R5023	T6170	T6160	cc	and,was
R5024	T6171	T6160	conj	is,was
R5025	T6172	T6173	advmod	therefore,independent
R5026	T6173	T6171	acomp	independent,is
R5027	T6174	T6173	prep	of,independent
R5028	T6175	T6176	compound	PKD,enzymes
R5029	T6176	T6174	pobj	enzymes,of
R5030	T6177	T6171	punct	.,is
R5031	T6178	T6201	advmod	However,prevented
R5032	T6179	T6201	punct	",",prevented
R5033	T6180	T6201	nsubj	pretreatment,prevented
R5034	T6181	T6180	prep	of,pretreatment
R5035	T6182	T6183	preconj	both,wild-type
R5036	T6183	T6181	pobj	wild-type,of
R5037	T6184	T6183	cc	and,wild-type
R5038	T6185	T6183	conj	PKD1/3,wild-type
R5039	T6186	T6188	compound	−,−
R5040	T6187	T6188	compound	/,−
R5041	T6188	T6191	compound	−,cells
R5042	T6189	T6190	compound	DT40,B
R5043	T6190	T6191	compound	B,cells
R5044	T6191	T6183	appos	cells,wild-type
R5045	T6192	T6180	prep	with,pretreatment
R5046	T6193	T6192	pobj	GF109203X,with
R5047	T6194	T6193	punct	",",GF109203X
R5048	T6195	T6197	det	a,derivative
R5049	T6196	T6197	compound	bisindoylmaleimide,derivative
R5050	T6197	T6193	appos	derivative,GF109203X
R5051	T6198	T6199	nsubj	that,inhibits
R5052	T6199	T6197	relcl	inhibits,derivative
R5053	T6200	T6199	dobj	PKCs,inhibits
R5054	T6201	T6201	ROOT	prevented,prevented
R5055	T6202	T6203	det	the,induction
R5056	T6203	T6201	dobj	induction,prevented
R5057	T6204	T6203	prep	of,induction
R5058	T6205	T6204	pobj	proteins,of
R5059	T6206	T6207	nsubj	that,contain
R5060	T6207	T6205	relcl	contain,proteins
R5061	T6208	T6209	compound	phosphorylated,LxRxxS/T
R5062	T6209	T6210	compound	LxRxxS/T,motifs
R5063	T6210	T6207	dobj	motifs,contain
R5064	T6211	T6201	punct	.,prevented
R5065	T6212	T6216	advmod	Thus,enzymes
R5066	T6213	T6216	nsubj	loss,enzymes
R5067	T6214	T6213	prep	of,loss
R5068	T6215	T6214	pobj	PKD1/3,of
R5069	T6216	T6220	nsubj	enzymes,disrupt
R5070	T6217	T6220	aux	does,disrupt
R5071	T6218	T6220	neg	not,disrupt
R5072	T6219	T6220	advmod	globally,disrupt
R5073	T6220	T6220	ROOT	disrupt,disrupt
R5074	T6221	T6222	det	the,phosphorylation
R5075	T6222	T6220	dobj	phosphorylation,disrupt
R5076	T6223	T6222	prep	of,phosphorylation
R5077	T6224	T6225	amod	cellular,proteins
R5078	T6225	T6223	pobj	proteins,of
R5132	T6279	T6278	prep	in,culminate
R5133	T6280	T6281	det	the,activation
R5134	T6281	T6279	pobj	activation,in
R5135	T6282	T6281	prep	of,activation
R5136	T6283	T6284	compound	gene,transcription
R5137	T6284	T6285	compound	transcription,events
R5138	T6285	T6282	pobj	events,of
R5139	T6286	T6287	nsubj	that,control
R5140	T6287	T6285	relcl	control,events
R5141	T6288	T6290	compound	B,survival
R5142	T6289	T6290	compound	cell,survival
R5143	T6290	T6287	dobj	survival,control
R5144	T6291	T6290	punct	",",survival
R5145	T6292	T6290	conj	proliferation,survival
R5146	T6293	T6292	cc	and,proliferation
R5147	T6294	T6292	conj	function,proliferation
R5148	T6295	T6278	punct	.,culminate
R5149	T6296	T6303	prep	In,proposed
R5150	T6297	T6298	det	this,context
R5151	T6298	T6296	pobj	context,In
R5152	T6299	T6303	punct	",",proposed
R5153	T6300	T6303	nsubjpass	it,proposed
R5154	T6301	T6303	aux	has,proposed
R5155	T6302	T6303	auxpass	been,proposed
R5156	T6303	T6303	ROOT	proposed,proposed
R5157	T6304	T6303	dobj	that,proposed
R5158	T6305	T6307	compound	PKD,members
R5159	T6306	T6307	compound	family,members
R5160	T6307	T6304	nsubj	members,that
R5161	T6308	T6307	dobj	control,members
R5162	T6309	T6308	prep	of,control
R5163	T6310	T6311	compound	gene,transcription
R5164	T6311	T6309	pobj	transcription,of
R5165	T6312	T6307	prep	through,members
R5166	T6313	T6312	pobj	activation,through
R5167	T6314	T6313	prep	of,activation
R5168	T6315	T6318	det	the,factor
R5169	T6316	T6318	compound	NFκB,factor
R5170	T6317	T6318	compound	transcription,factor
R5171	T6318	T6314	pobj	factor,of
R5172	T6319	T6303	punct	.,proposed
R5173	T6320	T6326	advmod	Thus,occurs
R5174	T6321	T6326	punct	",",occurs
R5175	T6322	T6323	amod	PKD-mediated,activation
R5176	T6323	T6326	nsubj	activation,occurs
R5177	T6324	T6323	prep	of,activation
R5178	T6325	T6324	pobj	NFκB,of
R5179	T6326	T6326	ROOT	occurs,occurs
R5180	T6327	T6326	advmod	downstream,occurs
R5181	T6328	T6327	prep	of,downstream
R5182	T6329	T6330	det	a,variety
R5183	T6330	T6328	pobj	variety,of
R5184	T6331	T6330	prep	of,variety
R5185	T6332	T6333	amod	different,signals
R5186	T6333	T6331	pobj	signals,of
R5187	T6334	T6333	punct	",",signals
R5188	T6335	T6333	prep	including,signals
R5189	T6336	T6337	amod	mROS/oxidative,stress
R5190	T6337	T6335	pobj	stress,including
R5191	T6338	T6337	punct	",",stress
R5192	T6339	T6340	amod	lysophosphatidic,acid
R5193	T6340	T6337	conj	acid,stress
R5194	T6341	T6340	cc	and,acid
R5195	T6342	T6344	det	the,oncogene
R5196	T6343	T6344	compound	Bcr-Abl,oncogene
R5197	T6344	T6340	conj	oncogene,acid
R5198	T6345	T6347	compound	[,]
R5199	T6346	T6347	compound	"17,21,23,30,37",]
R5200	T6347	T6344	appos	],oncogene
R5201	T6348	T6326	punct	.,occurs
R5202	T6349	T6357	advmod	Furthermore,enhances
R5203	T6350	T6351	punct	",",expression
R5204	T6351	T6357	nsubj	expression,enhances
R5205	T6352	T6351	prep	of,expression
R5206	T6353	T6356	det	an,mutant
R5207	T6354	T6356	amod	activated,mutant
R5208	T6355	T6356	compound	PKD1,mutant
R5209	T6356	T6352	pobj	mutant,of
R5210	T6357	T6357	ROOT	enhances,enhances
R5211	T6358	T6360	amod	HPK1-mediated,activation
R5212	T6359	T6360	compound	NFκB,activation
R5213	T6360	T6357	dobj	activation,enhances
R5214	T6361	T6363	nmod	[,]
R5215	T6362	T6363	nummod	38,]
R5216	T6363	T6357	npadvmod	],enhances
R5217	T6364	T6357	punct	.,enhances
R5218	T6365	T6371	prep	In,known
R5219	T6366	T6367	compound	B,cells
R5220	T6367	T6365	pobj	cells,In
R5221	T6368	T6371	punct	",",known
R5222	T6369	T6371	nsubjpass	NFκB,known
R5223	T6370	T6371	auxpass	is,known
R5224	T6371	T6371	ROOT	known,known
R5225	T6372	T6374	aux	to,regulated
R5226	T6373	T6374	auxpass	be,regulated
R5227	T6374	T6371	xcomp	regulated,known
R5228	T6375	T6374	prep	via,regulated
R5229	T6376	T6375	pobj	DAG,via
R5230	T6377	T6376	cc	and,DAG
R5231	T6378	T6379	compound	PKCβ,[
R5232	T6379	T6376	conj	[,DAG
R5233	T6380	T6381	compound	"39,40",]
R5234	T6381	T6376	conj	],DAG
R5235	T6382	T6371	cc	but,known
R5236	T6383	T6385	mark	whether,are
R5237	T6384	T6385	nsubj	PKDs,are
R5238	T6385	T6371	conj	are,known
R5239	T6386	T6387	amod	key,intermediaries
R5240	T6387	T6385	attr	intermediaries,are
R5241	T6388	T6385	prep	for,are
R5242	T6389	T6390	compound	NFκB,regulation
R5243	T6406	T6409	nsubjpass	activity,induced
R5244	T6390	T6388	pobj	regulation,for
R5245	T6407	T6409	auxpass	was,induced
R5246	T6408	T6409	advmod	strongly,induced
R5247	T6391	T6394	aux	has,explored
R5248	T6409	T6402	ccomp	induced,show
R5249	T6410	T6409	prep	in,induced
R5250	T6392	T6394	neg	not,explored
R5251	T6411	T6412	preconj	both,wild-type
R5252	T6393	T6394	auxpass	been,explored
R5253	T6412	T6417	nmod	wild-type,−
R5254	T6394	T6385	conj	explored,are
R5255	T6413	T6412	cc	and,wild-type
R5256	T6414	T6412	conj	PKD1/3,wild-type
R5257	T6415	T6417	compound	−,−
R5258	T6395	T6371	punct	.,known
R5259	T6416	T6417	compound	/,−
R5260	T6417	T6420	compound	−,cells
R5261	T6418	T6419	compound	DT40,B
R5262	T6396	T6397	det	The,data
R5263	T6419	T6420	compound	B,cells
R5264	T6420	T6410	pobj	cells,in
R5265	T6421	T6409	prep	in,induced
R5266	T6397	T6402	nsubj	data,show
R5267	T6422	T6421	pobj	response,in
R5268	T6423	T6422	prep	to,response
R5269	T6398	T6397	punct	(,data
R5270	T6424	T6426	preconj	either,ester
R5271	T6425	T6426	compound	phorbol,ester
R5272	T6399	T6400	compound	Fig.,4A
R5273	T6426	T6423	pobj	ester,to
R5274	T6427	T6426	cc	or,ester
R5275	T6428	T6429	compound	BCR,stimulation
R5276	T6429	T6426	conj	stimulation,ester
R5277	T6430	T6402	punct	.,show
R5278	T6431	T6442	prep	In,abolished
R5279	T6432	T6431	pobj	contrast,In
R5280	T6400	T6397	appos	4A,data
R5281	T6433	T6442	punct	",",abolished
R5282	T6434	T6440	nmod	BCR,activity
R5283	T6401	T6397	punct	),data
R5284	T6435	T6434	cc	and,BCR
R5285	T6436	T6440	amod	phorbol,activity
R5286	T6437	T6440	amod	ester-induced,activity
R5287	T6438	T6440	nmod	NFκB,activity
R5288	T6439	T6440	amod	transcriptional,activity
R5289	T6402	T6402	ROOT	show,show
R5290	T6440	T6442	nsubjpass	activity,abolished
R5291	T6441	T6442	auxpass	was,abolished
R5292	T6403	T6409	mark	that,induced
R5293	T6442	T6442	ROOT	abolished,abolished
R5294	T6443	T6442	prep	in,abolished
R5295	T6444	T6449	compound	PKCβ,B
R5296	T6404	T6406	nmod	NFκB,activity
R5297	T6445	T6449	compound	−,B
R5298	T6446	T6449	compound	/,B
R5299	T6447	T6449	compound	−,B
R5300	T6405	T6406	amod	transcriptional,activity
R5301	T6448	T6449	compound	DT40,B
R5302	T6449	T6450	compound	B,cells
R5304	T6450	T6443	pobj	cells,in
R5305	T6451	T6442	punct	(,abolished
R2447	T2898	T2897	prep	upon,restored
R2448	T2899	T2898	pobj	re-expression,upon
R2449	T2900	T2899	prep	of,re-expression
R2450	T2901	T2904	det	a,isoform
R2452	T2903	T2904	compound	PKD,isoform
R2453	T2904	T2900	pobj	isoform,of
R2454	T2905	T2907	nmod	[,]
R2455	T2906	T2907	nummod	1,]
R2456	T2907	T2869	dobj	],demonstrated
R2457	T2908	T2869	punct	.,demonstrated
R2458	T2909	T2913	det	The,protein
R2459	T2910	T2913	amod	small,protein
R2460	T2911	T2912	compound	heat,shock
R2461	T2912	T2913	compound	shock,protein
R2462	T2913	T2918	nsubj	protein,proposed
R2463	T2914	T2913	appos	HSP27,protein
R2464	T2915	T2918	aux	has,proposed
R2465	T2916	T2918	advmod	recently,proposed
R2466	T2917	T2918	auxpass	been,proposed
R2467	T2918	T2918	ROOT	proposed,proposed
R2468	T2919	T2918	prep	as,proposed
R2469	T2920	T2922	det	a,substrate
R2470	T2921	T2922	compound	PKD1,substrate
R2471	T2922	T2919	pobj	substrate,as
R2472	T2923	T2925	nmod	[,]
R2473	T2924	T2925	nummod	24,]
R2474	T2925	T2922	dep	],substrate
R2475	T2926	T2922	cc	and,substrate
R2476	T2927	T2929	nsubj	we,assessed
R2477	T2928	T2929	advmod	accordingly,assessed
R2478	T2929	T2922	conj	assessed,substrate
R2479	T2930	T2934	mark	whether,have
R2480	T2931	T2932	compound	PKD-null,DT40
R2481	T2932	T2933	compound	DT40,cells
R2482	T2933	T2934	nsubj	cells,have
R2483	T2934	T2929	ccomp	have,assessed
R2484	T2935	T2936	amod	defective,phosphorylation
R2485	T2936	T2934	dobj	phosphorylation,have
R2486	T2937	T2936	prep	of,phosphorylation
R2487	T2938	T2937	pobj	HSP27,of
R3651	T4452	T4450	conj	proliferation,survival
R3652	T4453	T4452	prep	of,proliferation
R3653	T4454	T4455	compound	DT40,B
R3654	T4455	T4456	compound	B,cells
R3655	T4456	T4453	pobj	cells,of
R3656	T4457	T4444	punct	.,are
R3657	T4458	T4459	compound	PKD,enzymes
R4850	T5997	T6001	nsubj	interpretation,is
R4851	T5998	T5997	prep	of,interpretation
R4852	T5999	T6000	det	this,data
R4853	T6000	T5998	pobj	data,of
R4931	T6078	T6079	compound	Flag-PKD3,+
R4932	T6079	T6074	appos	+,−
R4933	T6080	T6074	punct	),−
R4934	T6081	T6082	amod	B,cells
R4935	T6082	T6085	nsubj	cells,impact
R4936	T6083	T6085	aux	may,impact
R4937	T6084	T6085	nsubj	itself,impact
R4938	T6085	T6085	ROOT	impact,impact
R5079	T6226	T6227	nsubj	that,contain
R5080	T6227	T6225	relcl	contain,proteins
R5081	T6228	T6229	compound	LxRxxpS/T,motifs
R5082	T6229	T6227	dobj	motifs,contain
R5083	T6230	T6220	punct	.,disrupt
R5084	T6231	T6232	det	This,result
R5085	T6232	T6233	nsubj	result,is
R5086	T6233	T6233	ROOT	is,is
R5087	T6234	T6236	advmod	perhaps,surprising
R5088	T6235	T6236	neg	not,surprising
R5089	T6236	T6233	acomp	surprising,is
R5090	T6237	T6241	mark	as,act
R5091	T6238	T6239	compound	LxRxxS/T,motifs
R5092	T6239	T6241	nsubj	motifs,act
R5093	T6240	T6241	advmod	also,act
R5094	T6241	T6236	advcl	act,surprising
R5095	T6242	T6241	prep	as,act
R5096	T6243	T6244	amod	good,substrates
R5097	T6244	T6242	pobj	substrates,as
R5098	T6245	T6244	prep	for,substrates
R5099	T6246	T6248	amod	other,kinases
R5100	T6247	T6248	amod	serine/threonine,kinases
R5101	T6248	T6245	pobj	kinases,for
R5102	T6249	T6250	amod	such,as
R5103	T6250	T6248	prep	as,kinases
R5104	T6251	T6250	pobj	MAPKAPK2,as
R5105	T6252	T6233	punct	.,is
R5106	T6253	T6257	advmod	However,provide
R5107	T6254	T6255	det	these,experiments
R5108	T6255	T6257	nsubj	experiments,provide
R5109	T6256	T6257	aux	do,provide
R5110	T6257	T6257	ROOT	provide,provide
R5111	T6258	T6259	amod	further,evidence
R5112	T6259	T6257	dobj	evidence,provide
R5113	T6260	T6263	mark	that,are
R5114	T6261	T6262	amod	phosphospecific,antisera
R5115	T6262	T6263	nsubj	antisera,are
R5116	T6263	T6259	acl	are,evidence
R5117	T6264	T6263	neg	not,are
R5118	T6265	T6266	advmod	sufficiently,selective
R5119	T6266	T6263	acomp	selective,are
R5120	T6267	T6269	aux	to,designated
R5121	T6268	T6269	auxpass	be,designated
R5122	T6269	T6266	xcomp	designated,selective
R5123	T6270	T6269	oprd	kinase,designated
R5124	T6271	T6273	amod	specific,antisera
R5125	T6272	T6273	compound	substrate,antisera
R5126	T6273	T6270	appos	antisera,kinase
R5127	T6274	T6257	punct	.,provide
R5128	T6275	T6277	amod	BCR-induced,pathways
R5129	T6276	T6277	amod	signalling,pathways
R5130	T6277	T6278	nsubj	pathways,culminate
R5131	T6278	T6278	ROOT	culminate,culminate
R5308	T6452	T6453	compound	Fig.,4A
R5310	T6453	T6442	npadvmod	4A,abolished
R5311	T6454	T6442	punct	),abolished
R5312	T6455	T6442	punct	",",abolished
R5313	T6456	T6473	mark	although,observed
R5315	T6457	T6458	amod	strong,activation
R5316	T6458	T6473	nsubjpass	activation,observed
R5318	T6459	T6458	prep	of,activation
R5319	T6460	T6461	compound	PKD,kinases
R5320	T6461	T6459	pobj	kinases,of
R5322	T6462	T6464	punct	(,assessed
R5323	T6463	T6464	mark	as,assessed
R5325	T6464	T6473	advcl	assessed,observed
R5326	T6465	T6464	agent	by,assessed
R5327	T6466	T6465	pobj	autophosphorylation,by
R5328	T6467	T6466	prep	of,autophosphorylation
R5329	T6468	T6467	pobj	PKD1,of
R5330	T6469	T6466	prep	at,autophosphorylation
R5331	T6470	T6469	pobj	S916,at
R5332	T6471	T6464	punct	),assessed
R5333	T6472	T6473	auxpass	was,observed
R5335	T6473	T6442	advcl	observed,abolished
R5336	T6474	T6473	prep	in,observed
R5338	T6475	T6477	det	the,−
R5339	T6476	T6477	compound	PKCβ,−
R5340	T6477	T6474	pobj	−,in
R5341	T6478	T6442	conj	/,abolished
R5343	T6479	T6480	nummod	−,cells
R5344	T6480	T6478	dobj	cells,/
R5345	T6481	T6483	punct	(,4B
R5347	T6482	T6483	compound	Fig.,4B
R5348	T6483	T6478	parataxis	4B,/
R5349	T6484	T6483	punct	),4B
R5351	T6485	T6442	punct	.,abolished
R5303	T6503	T6500	pobj	cells,in
R5306	T6504	T6496	cc	and,mediate
R5307	T6505	T6508	advmod	hence,participate
R5309	T6506	T6508	aux	do,participate
R5314	T6507	T6508	neg	not,participate
R5317	T6508	T6496	conj	participate,mediate
R5321	T6509	T6508	prep	in,participate
R5324	T6510	T6509	pobj	DAG/PKC,in
R5334	T6511	T6490	conj	mediated,are
R5337	T6512	T6511	dobj	control,mediated
R5342	T6513	T6512	prep	of,control
R5346	T6514	T6513	pobj	NFκB,of
R5350	T6515	T6490	punct	.,are
R5353	T6486	T6490	advmod	Thus,are
R5354	T6487	T6490	punct	",",are
R5355	T6488	T6489	compound	PKD,kinases
R5356	T6489	T6490	nsubj	kinases,are
R5357	T6490	T6490	ROOT	are,are
R5358	T6491	T6492	advmod	neither,essential
R5359	T6492	T6490	acomp	essential,are
R5360	T6493	T6492	cc	nor,essential
R5361	T6494	T6492	conj	sufficient,essential
R5362	T6495	T6496	aux	to,mediate
R5363	T6496	T6494	xcomp	mediate,sufficient
R5364	T6497	T6499	amod	BCR-induced,activation
R5365	T6498	T6499	compound	NFκB,activation
R5366	T6499	T6496	dobj	activation,mediate
R5367	T6500	T6499	prep	in,activation
R5368	T6501	T6502	compound	DT40,B
R5369	T6502	T6503	compound	B,cells

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T3782	4045-4050	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T2272	31-46	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T2273	792-807	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T2274	1150-1165	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T2275	1277-1292	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T2276	1466-1481	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T2277	1579-1594	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T2278	1691-1706	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T2279	1945-1960	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T2280	2127-2142	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T2281	2201-2216	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T2282	1002-1020	http://purl.obolibrary.org/obo/GO_0006986	denotes	heat shock protein
T2283	1002-1020	http://purl.obolibrary.org/obo/GO_0034620	denotes	heat shock protein
T3833	3832-3860	http://purl.obolibrary.org/obo/GO_1902884	denotes	response to oxidative stress
T3834	3832-3860	http://purl.obolibrary.org/obo/GO_0034599	denotes	response to oxidative stress
T3835	3995-4027	http://purl.obolibrary.org/obo/GO_1990046	denotes	response to mitochondrial stress
T6532	6344-6359	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6533	6464-6479	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6534	6900-6915	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6535	5152-5156	http://purl.obolibrary.org/obo/GO_0004707	denotes	MAPK
T6536	5152-5167	http://purl.obolibrary.org/obo/GO_0000165	denotes	MAPK signalling
T6537	5293-5301	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T6538	6483-6491	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T3820	2433-2443	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T3821	2433-2465	http://purl.obolibrary.org/obo/GO_0030888	denotes	regulation of cell proliferation
T3822	2433-2465	http://purl.obolibrary.org/obo/GO_0051140	denotes	regulation of cell proliferation
T3823	2433-2465	http://purl.obolibrary.org/obo/GO_0060251	denotes	regulation of cell proliferation
T3824	2433-2465	http://purl.obolibrary.org/obo/GO_0070666	denotes	regulation of cell proliferation
T3825	2433-2465	http://purl.obolibrary.org/obo/GO_1904073	denotes	regulation of cell proliferation
T3826	2433-2465	http://purl.obolibrary.org/obo/GO_1904697	denotes	regulation of cell proliferation
T3827	2433-2465	http://purl.obolibrary.org/obo/GO_1904441	denotes	regulation of cell proliferation
T3828	2447-2465	http://purl.obolibrary.org/obo/GO_0008283	denotes	cell proliferation
T3829	2741-2747	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T3830	3832-3860	http://purl.obolibrary.org/obo/GO_1902883	denotes	response to oxidative stress
T3831	3832-3860	http://purl.obolibrary.org/obo/GO_0006979	denotes	response to oxidative stress
T3832	3832-3860	http://purl.obolibrary.org/obo/GO_0097468	denotes	response to oxidative stress
T2284	1002-1020	http://purl.obolibrary.org/obo/GO_0042026	denotes	heat shock protein
T2285	1257-1267	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T2286	1925-1935	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T2287	1538-1545	http://purl.obolibrary.org/obo/GO_0023052	denotes	signals
T6516	4439-4449	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6517	4605-4615	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6518	4960-4970	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6519	5157-5167	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6520	5551-5561	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6521	5808-5818	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6522	6153-6163	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6523	7286-7296	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T6524	7648-7655	http://purl.obolibrary.org/obo/GO_0023052	denotes	signals
T6525	4439-4458	http://purl.obolibrary.org/obo/GO_0007165	denotes	signalling pathways
T6526	5157-5176	http://purl.obolibrary.org/obo/GO_0007165	denotes	signalling pathways
T6527	4960-4979	http://purl.obolibrary.org/obo/GO_0007165	denotes	signalling cascades
T6528	5123-5146	http://purl.obolibrary.org/obo/GO_0006468	denotes	protein phosphorylation
T6529	5131-5146	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6530	5265-5280	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6531	5894-5909	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6539	6919-6927	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T6540	5523-5533	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T6541	6239-6249	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T6542	7968-7978	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T6543	5780-5786	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T6544	6139-6171	http://purl.obolibrary.org/obo/GO_0030522	denotes	intracellular signalling pathway
T6545	6139-6171	http://purl.obolibrary.org/obo/GO_0035556	denotes	intracellular signalling pathway
T6546	6139-6171	http://purl.obolibrary.org/obo/GO_1902532	denotes	intracellular signalling pathway
T6547	6139-6171	http://purl.obolibrary.org/obo/GO_1902531	denotes	intracellular signalling pathway
T6548	6139-6171	http://purl.obolibrary.org/obo/GO_1902533	denotes	intracellular signalling pathway
T6549	7342-7355	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6550	7499-7512	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6551	7544-7557	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6552	8036-8051	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T6553	8231-8246	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T6554	8591-8594	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T6581	5113-5130	http://purl.obolibrary.org/obo/GO_0003735	denotes	ribosomal protein
T6582	5152-5156	http://purl.obolibrary.org/obo/GO_0004707	denotes	MAPK
T6583	6309-6317	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibody
T6584	6528-6536	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibody
T6585	8591-8594	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T4613	2339-2344	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4614	2629-2634	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4615	2780-2785	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4616	2853-2858	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4617	2945-2950	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4618	3033-3038	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4619	3117-3122	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4620	3171-3176	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4621	3296-3301	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4622	3546-3551	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4623	3986-3991	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4624	4340-4344	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T4625	4113-4115	http://purl.obolibrary.org/obo/GO_0005783	denotes	ER
T6555	4478-4483	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6556	4656-4661	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6557	4784-4789	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6558	4819-4824	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6559	4899-4904	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6560	5019-5024	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6561	5217-5222	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6562	5427-5432	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6563	5597-5602	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6564	5627-5632	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6565	5953-5958	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6566	6068-6073	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6567	6270-6275	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6568	6576-6581	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6569	6688-6693	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6570	7857-7862	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6571	8121-8126	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6572	8288-8293	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6573	8428-8433	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6574	8549-8554	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6575	5337-5350	http://purl.obolibrary.org/obo/GO_0005622	denotes	intracellular
T6576	6139-6152	http://purl.obolibrary.org/obo/GO_0005622	denotes	intracellular
T6577	6309-6317	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibody
T6578	6528-6536	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibody
T6579	6309-6317	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibody
T6580	6528-6536	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibody
T3137	57-62	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3138	111-116	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3139	568-573	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3140	633-638	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3141	921-926	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3142	1129-1134	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3143	1319-1324	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3144	1509-1514	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3145	1634-1639	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3146	1742-1747	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3147	1886-1891	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3148	2061-2066	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3149	2231-2236	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

sentences

Id	Subject	Object	Predicate	Lexical cue
T2260	104-295	Sentence	denotes	DT40 B cells express two PKD isoforms, PKD1 and PKD3, and as previously described we have recently generated DT40 B cell lines that lack expression of either PKD1 or PKD3 or both enzymes [1].
T2261	296-481	Sentence	denotes	In generating the double knockout cell lines we targeted the PKD1 loci in a PKD3−/− cell line that expressed a Flag-PKD3 transgene under the control of a doxycycline-inducible promoter.
T2262	482-753	Sentence	denotes	Hence, in the presence of doxycycline, Flag-PKD3 expression in PKD1/3 double knockout cells is comparable to endogenous PKD3 present in wild-type DT40 cells and removal of doxycycline from the culture media for 5 days results in a completely null PKD phenotype (Fig. 1A).
T2263	754-991	Sentence	denotes	Previously, we have demonstrated that phosphorylation and nuclear exclusion of class II histone deacetylases (HDACs) during BCR engagement is defective in PKD1/3−/− B cells and can restored upon re-expression of a single PKD isoform [1].
T2264	992-1226	Sentence	denotes	The small heat shock protein HSP27 has recently been proposed as a PKD1 substrate [24] and we accordingly assessed whether PKD-null DT40 cells have defective phosphorylation of HSP27 on serine 82, the proposed PKD1 substrate sequence.
T2265	1227-1353	Sentence	denotes	We initially investigated the regulation of HSP27 phosphorylation in single knockout DT40 B cells lacking either PKD1 or PKD3.
T2266	1354-1515	Sentence	denotes	As shown in Fig. 1B, activation of the BCR or treatment with the DAG-mimetic PdBu increased the levels of HSP27 phosphorylation at S82 in wild-type DT40 B cells.
T2267	1516-1650	Sentence	denotes	BCR and phorbol ester signals were also able to increase HSP27 phosphorylation in PKD1 or PKD3 single knockout DT40 B cells (Fig. 1B).
T2268	1651-1789	Sentence	denotes	However, BCR- and phorbol ester-induced phosphorylation of HSP27 on S82 was abolished in B cells that lacked both PKD1 and PKD3 (Fig. 1C).
T2269	1790-1971	Sentence	denotes	Significantly, doxycycline-induced expression of the Flag-PKD3 transgene in the double knockout cells was sufficient to restore normal regulation of HSP27 phosphorylation (Fig. 1C).
T2270	1972-2153	Sentence	denotes	In contrast, expression of a kinase-deficient PKD3 mutant protein in the double knockout cells was not able to restore BCR- or phorbol ester-induced HSP27 phosphorylation (Fig. 1D).
T2271	2154-2286	Sentence	denotes	Hence, PKD3 as well as PKD1 can regulate HSP27 phosphorylation and in DT40 B cells they are functionally redundant as HSP27 kinases.
T3809	2386-2498	Sentence	denotes	PKD enzymes have previously been linked to the regulation of cell proliferation and survival (reviewed in [20]).
T3810	2499-2662	Sentence	denotes	To investigate the effect that loss of PKD kinases had on B cell survival and/or proliferation we cultured wild-type and PKD-null cells in the presence (PKD1/3−/−:
T3811	2663-2748	Sentence	denotes	Flag-PKD3+ve) or absence (PKD1/3−/−) of doxycycline and monitored exponential growth.
T3812	2749-2902	Sentence	denotes	As shown in Fig. 2A, PKD1/3−/− cells proliferated exponentially and re-expression of Flag-PKD3 in these cells had no impact on the rate of proliferation.
T3813	2903-3056	Sentence	denotes	Furthermore, the viability of PKD1/3−/− B cells during routine culturing was not significantly different from that of wild-type B cells (data not shown).
T3814	3057-3444	Sentence	denotes	It was noted that the population doubling time of PKD1/3−/− cells was slightly slower than that of wild type DT40 cells (12.7 ± 2.8 h versus 10.2 ± 0.4 h) but the failure of PKD3 re-expression to modify the proliferation rate of PKD1/3−/− cells suggests that these small differences were most likely the result of clonal variation and were not caused specifically by loss of PKD enzymes.
T3815	3445-3552	Sentence	denotes	Thus, PKD family enzymes are not essential for regulating basal survival and proliferation of DT40 B cells.
T3816	3553-3744	Sentence	denotes	PKD enzymes, specifically PKD1 and PKD2, have previously been linked to a protective role against oxidative stress-induced injury in 3T3 fibroblast, HeLa and epithelial cell lines [17,30–32].
T3817	3745-3886	Sentence	denotes	We therefore addressed the role of PKD family kinases in regulating B cell survival in response to oxidative stress and other stress stimuli.
T3818	3887-4275	Sentence	denotes	As shown in Fig. 2B, loss of PKD1/3 expression had no significant impact on the survival of DT40 B cells in response to mitochondrial stress stimuli (H2O2 or serum deprivation); DNA damaging agents (etoposide or doxorubicin); ER pathway stress due to calcium overload (thapsigargin) or following prolonged treatment with phorbol esters or Trichostatin A, an inhibitor of class I/II HDACs.
T3819	4276-4405	Sentence	denotes	Thus, PKD kinases do not play an essential role in regulating B cell survival in response to a range of different stress stimuli.
T5008	4484-4662	Sentence	denotes	To further explore the contribution of PKD kinases to DT40 B cell biology we investigated whether specific BCR-regulated signalling events were defective in the PKD-null B cells.
T5009	4663-4854	Sentence	denotes	Initial experiments revealed that surface expression of the BCR was reduced in PKD1/3−/− (and in PKD1/3−/−:Flag-PKD3+ve) cells compared to wild-type DT40 B cells (Fig. 3A and data not shown).
T5010	4855-5035	Sentence	denotes	Nevertheless, BCR-crosslinking of PKD1/3−/− cells was sufficient to induce the activation of a number of signalling cascades, similar to that observed in wild-type cells (Fig. 3B).
T5011	5036-5233	Sentence	denotes	Hence, BCR-induced activation of the Akt, mTOR/p70 S6 kinase (as shown by S6 ribosomal protein phosphorylation) and MAPK signalling pathways was clearly detectable in PKD1/3-null B cells (Fig. 3B).
T5012	5234-5450	Sentence	denotes	Furthermore, enhanced tyrosine phosphorylation of multiple cellular proteins as well as an increase in intracellular calcium levels was also observed following BCR stimulation of PKD1/3-null B cells (data not shown).
T5013	5451-5643	Sentence	denotes	We did observe that the strength of BCR (but not phorbol ester)-induced regulation of the Erk1-RSK1 signalling pathway was reduced in PKD1/3−/− B cells compared to wild-type B cells (Fig. 3B).
T5014	5644-5724	Sentence	denotes	One interpretation of this data is that PKD enzymes may modulate Erk activation.
T5015	5725-5868	Sentence	denotes	Indeed, PKD enzymes have previously been linked to the growth factor-regulated Erk signalling in fibroblast and endothelial cell lines [33–35].
T5016	5869-6172	Sentence	denotes	However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway.
T5017	6173-6411	Sentence	denotes	To search for other potential PKD targets that may show defective regulation in PKD1/3−/− DT40 B cells, we used a PKD substrate phospho-antibody that recognises consensus phosphorylation sequences targeted by PKD enzymes (LxRxxpS/T) [36].
T5018	6412-6626	Sentence	denotes	As shown in Fig. 3C, phorbol ester- and BCR-induced phosphorylation of cellular substrates detected by this phospho-antibody was similar in wild-type and PKD1/3−/− cells and is therefore independent of PKD enzymes.
T5019	6627-6841	Sentence	denotes	However, pretreatment of both wild-type and PKD1/3−/− DT40 B cells with GF109203X, a bisindoylmaleimide derivative that inhibits PKCs prevented the induction of proteins that contain phosphorylated LxRxxS/T motifs.
T5020	6842-6967	Sentence	denotes	Thus loss of PKD1/3 enzymes does not globally disrupt the phosphorylation of cellular proteins that contain LxRxxpS/T motifs.
T5021	6968-7105	Sentence	denotes	This result is perhaps not surprising as LxRxxS/T motifs also act as good substrates for other serine/threonine kinases such as MAPKAPK2.
T5022	7106-7273	Sentence	denotes	However these experiments do provide further evidence that phosphospecific antisera are not sufficiently selective to be designated kinase specific substrate antisera.
T5023	7274-7420	Sentence	denotes	BCR-induced signalling pathways culminate in the activation of gene transcription events that control B cell survival, proliferation and function.
T5024	7421-7565	Sentence	denotes	In this context, it has been proposed that PKD family members control of gene transcription through activation of the NFκB transcription factor.
T5025	7566-7754	Sentence	denotes	Thus, PKD-mediated activation of NFκB occurs downstream of a variety of different signals, including mROS/oxidative stress, lysophosphatidic acid and the Bcr-Abl oncogene [17,21,23,30,37].
T5026	7755-7851	Sentence	denotes	Furthermore, expression of an activated PKD1 mutant enhances HPK1-mediated NFκB activation [38].
T5027	7852-8001	Sentence	denotes	In B cells, NFκB is known to be regulated via DAG and PKCβ [39,40] but whether PKDs are key intermediaries for NFκB regulation has not been explored.
T5028	8002-8182	Sentence	denotes	The data (Fig. 4A) show that NFκB transcriptional activity was strongly induced in both wild-type and PKD1/3−/− DT40 B cells in response to either phorbol ester or BCR stimulation.
T5029	8183-8444	Sentence	denotes	In contrast, BCR and phorbol ester-induced NFκB transcriptional activity was abolished in PKCβ−/− DT40 B cells (Fig. 4A), although strong activation of PKD kinases (as assessed by autophosphorylation of PKD1 at S916) was observed in the PKCβ−/− cells (Fig. 4B).
T5030	8445-8620	Sentence	denotes	Thus, PKD kinases are neither essential nor sufficient to mediate BCR-induced NFκB activation in DT40 B cells and hence do not participate in DAG/PKC mediated control of NFκB.
T36	0-10	Sentence	denotes	3 Results
T37	12-103	Sentence	denotes	3.1 Loss of HSP27 phosphorylation in DT40 B cells lacking expression of PKD family kinases
T38	104-295	Sentence	denotes	DT40 B cells express two PKD isoforms, PKD1 and PKD3, and as previously described we have recently generated DT40 B cell lines that lack expression of either PKD1 or PKD3 or both enzymes [1].
T39	296-481	Sentence	denotes	In generating the double knockout cell lines we targeted the PKD1 loci in a PKD3−/− cell line that expressed a Flag-PKD3 transgene under the control of a doxycycline-inducible promoter.
T40	482-753	Sentence	denotes	Hence, in the presence of doxycycline, Flag-PKD3 expression in PKD1/3 double knockout cells is comparable to endogenous PKD3 present in wild-type DT40 cells and removal of doxycycline from the culture media for 5 days results in a completely null PKD phenotype (Fig. 1A).
T41	754-991	Sentence	denotes	Previously, we have demonstrated that phosphorylation and nuclear exclusion of class II histone deacetylases (HDACs) during BCR engagement is defective in PKD1/3−/− B cells and can restored upon re-expression of a single PKD isoform [1].
T42	992-1226	Sentence	denotes	The small heat shock protein HSP27 has recently been proposed as a PKD1 substrate [24] and we accordingly assessed whether PKD-null DT40 cells have defective phosphorylation of HSP27 on serine 82, the proposed PKD1 substrate sequence.
T43	1227-1353	Sentence	denotes	We initially investigated the regulation of HSP27 phosphorylation in single knockout DT40 B cells lacking either PKD1 or PKD3.
T44	1354-1515	Sentence	denotes	As shown in Fig. 1B, activation of the BCR or treatment with the DAG-mimetic PdBu increased the levels of HSP27 phosphorylation at S82 in wild-type DT40 B cells.
T45	1516-1650	Sentence	denotes	BCR and phorbol ester signals were also able to increase HSP27 phosphorylation in PKD1 or PKD3 single knockout DT40 B cells (Fig. 1B).
T46	1651-1789	Sentence	denotes	However, BCR- and phorbol ester-induced phosphorylation of HSP27 on S82 was abolished in B cells that lacked both PKD1 and PKD3 (Fig. 1C).
T47	1790-1971	Sentence	denotes	Significantly, doxycycline-induced expression of the Flag-PKD3 transgene in the double knockout cells was sufficient to restore normal regulation of HSP27 phosphorylation (Fig. 1C).
T48	1972-2153	Sentence	denotes	In contrast, expression of a kinase-deficient PKD3 mutant protein in the double knockout cells was not able to restore BCR- or phorbol ester-induced HSP27 phosphorylation (Fig. 1D).
T49	2154-2286	Sentence	denotes	Hence, PKD3 as well as PKD1 can regulate HSP27 phosphorylation and in DT40 B cells they are functionally redundant as HSP27 kinases.
T50	2288-2385	Sentence	denotes	3.2 Cellular proliferation and survival in DT40 B cells lacking expression of PKD family kinases
T51	2386-2498	Sentence	denotes	PKD enzymes have previously been linked to the regulation of cell proliferation and survival (reviewed in [20]).
T52	2499-2662	Sentence	denotes	To investigate the effect that loss of PKD kinases had on B cell survival and/or proliferation we cultured wild-type and PKD-null cells in the presence (PKD1/3−/−:
T53	2663-2748	Sentence	denotes	Flag-PKD3+ve) or absence (PKD1/3−/−) of doxycycline and monitored exponential growth.
T54	2749-2902	Sentence	denotes	As shown in Fig. 2A, PKD1/3−/− cells proliferated exponentially and re-expression of Flag-PKD3 in these cells had no impact on the rate of proliferation.
T55	2903-3056	Sentence	denotes	Furthermore, the viability of PKD1/3−/− B cells during routine culturing was not significantly different from that of wild-type B cells (data not shown).
T56	3057-3444	Sentence	denotes	It was noted that the population doubling time of PKD1/3−/− cells was slightly slower than that of wild type DT40 cells (12.7 ± 2.8 h versus 10.2 ± 0.4 h) but the failure of PKD3 re-expression to modify the proliferation rate of PKD1/3−/− cells suggests that these small differences were most likely the result of clonal variation and were not caused specifically by loss of PKD enzymes.
T57	3445-3552	Sentence	denotes	Thus, PKD family enzymes are not essential for regulating basal survival and proliferation of DT40 B cells.
T58	3553-3744	Sentence	denotes	PKD enzymes, specifically PKD1 and PKD2, have previously been linked to a protective role against oxidative stress-induced injury in 3T3 fibroblast, HeLa and epithelial cell lines [17,30–32].
T59	3745-3886	Sentence	denotes	We therefore addressed the role of PKD family kinases in regulating B cell survival in response to oxidative stress and other stress stimuli.
T60	3887-4275	Sentence	denotes	As shown in Fig. 2B, loss of PKD1/3 expression had no significant impact on the survival of DT40 B cells in response to mitochondrial stress stimuli (H2O2 or serum deprivation); DNA damaging agents (etoposide or doxorubicin); ER pathway stress due to calcium overload (thapsigargin) or following prolonged treatment with phorbol esters or Trichostatin A, an inhibitor of class I/II HDACs.
T61	4276-4405	Sentence	denotes	Thus, PKD kinases do not play an essential role in regulating B cell survival in response to a range of different stress stimuli.
T62	4407-4483	Sentence	denotes	3.3 Antigen receptor regulated signalling pathways in PKD-null DT40 B cells
T63	4484-4662	Sentence	denotes	To further explore the contribution of PKD kinases to DT40 B cell biology we investigated whether specific BCR-regulated signalling events were defective in the PKD-null B cells.
T64	4663-4854	Sentence	denotes	Initial experiments revealed that surface expression of the BCR was reduced in PKD1/3−/− (and in PKD1/3−/−:Flag-PKD3+ve) cells compared to wild-type DT40 B cells (Fig. 3A and data not shown).
T65	4855-5035	Sentence	denotes	Nevertheless, BCR-crosslinking of PKD1/3−/− cells was sufficient to induce the activation of a number of signalling cascades, similar to that observed in wild-type cells (Fig. 3B).
T66	5036-5233	Sentence	denotes	Hence, BCR-induced activation of the Akt, mTOR/p70 S6 kinase (as shown by S6 ribosomal protein phosphorylation) and MAPK signalling pathways was clearly detectable in PKD1/3-null B cells (Fig. 3B).
T67	5234-5450	Sentence	denotes	Furthermore, enhanced tyrosine phosphorylation of multiple cellular proteins as well as an increase in intracellular calcium levels was also observed following BCR stimulation of PKD1/3-null B cells (data not shown).
T68	5451-5643	Sentence	denotes	We did observe that the strength of BCR (but not phorbol ester)-induced regulation of the Erk1-RSK1 signalling pathway was reduced in PKD1/3−/− B cells compared to wild-type B cells (Fig. 3B).
T69	5644-5724	Sentence	denotes	One interpretation of this data is that PKD enzymes may modulate Erk activation.
T70	5725-5868	Sentence	denotes	Indeed, PKD enzymes have previously been linked to the growth factor-regulated Erk signalling in fibroblast and endothelial cell lines [33–35].
T71	5869-6172	Sentence	denotes	However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway.
T72	6173-6411	Sentence	denotes	To search for other potential PKD targets that may show defective regulation in PKD1/3−/− DT40 B cells, we used a PKD substrate phospho-antibody that recognises consensus phosphorylation sequences targeted by PKD enzymes (LxRxxpS/T) [36].
T73	6412-6626	Sentence	denotes	As shown in Fig. 3C, phorbol ester- and BCR-induced phosphorylation of cellular substrates detected by this phospho-antibody was similar in wild-type and PKD1/3−/− cells and is therefore independent of PKD enzymes.
T74	6627-6841	Sentence	denotes	However, pretreatment of both wild-type and PKD1/3−/− DT40 B cells with GF109203X, a bisindoylmaleimide derivative that inhibits PKCs prevented the induction of proteins that contain phosphorylated LxRxxS/T motifs.
T75	6842-6967	Sentence	denotes	Thus loss of PKD1/3 enzymes does not globally disrupt the phosphorylation of cellular proteins that contain LxRxxpS/T motifs.
T76	6968-7105	Sentence	denotes	This result is perhaps not surprising as LxRxxS/T motifs also act as good substrates for other serine/threonine kinases such as MAPKAPK2.
T77	7106-7273	Sentence	denotes	However these experiments do provide further evidence that phosphospecific antisera are not sufficiently selective to be designated kinase specific substrate antisera.
T78	7274-7420	Sentence	denotes	BCR-induced signalling pathways culminate in the activation of gene transcription events that control B cell survival, proliferation and function.
T79	7421-7565	Sentence	denotes	In this context, it has been proposed that PKD family members control of gene transcription through activation of the NFκB transcription factor.
T80	7566-7754	Sentence	denotes	Thus, PKD-mediated activation of NFκB occurs downstream of a variety of different signals, including mROS/oxidative stress, lysophosphatidic acid and the Bcr-Abl oncogene [17,21,23,30,37].
T81	7755-7851	Sentence	denotes	Furthermore, expression of an activated PKD1 mutant enhances HPK1-mediated NFκB activation [38].
T82	7852-8001	Sentence	denotes	In B cells, NFκB is known to be regulated via DAG and PKCβ [39,40] but whether PKDs are key intermediaries for NFκB regulation has not been explored.
T83	8002-8182	Sentence	denotes	The data (Fig. 4A) show that NFκB transcriptional activity was strongly induced in both wild-type and PKD1/3−/− DT40 B cells in response to either phorbol ester or BCR stimulation.
T84	8183-8444	Sentence	denotes	In contrast, BCR and phorbol ester-induced NFκB transcriptional activity was abolished in PKCβ−/− DT40 B cells (Fig. 4A), although strong activation of PKD kinases (as assessed by autophosphorylation of PKD1 at S916) was observed in the PKCβ−/− cells (Fig. 4B).
T85	8445-8620	Sentence	denotes	Thus, PKD kinases are neither essential nor sufficient to mediate BCR-induced NFκB activation in DT40 B cells and hence do not participate in DAG/PKC mediated control of NFκB.

ICD10

Id	Subject	Object	Predicate	Lexical cue
T3136	1007-1012	http://purl.bioontology.org/ontology/ICD10/R57.9	denotes	shock
T4612	3676-3682	http://purl.bioontology.org/ontology/ICD10/T14.9	denotes	injury

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T3563	602-606	Protein	denotes	PKD3
T3564	909-913	Protein	denotes	PKD1
T3565	914-915	Protein	denotes	3
T3566	1021-1026	Protein	denotes	HSP27
T3567	1059-1063	Protein	denotes	PKD1
T3568	1140-1149	Negative_regulation	denotes	defective
T3569	1150-1165	Phosphorylation	denotes	phosphorylation
T3570	1169-1174	Protein	denotes	HSP27
T3571	1178-1187	Entity	denotes	serine 82
T3572	1202-1206	Protein	denotes	PKD1
T3573	1257-1267	Regulation	denotes	regulation		true
T3574	1271-1276	Protein	denotes	HSP27
T3575	1277-1292	Phosphorylation	denotes	phosphorylation
T3576	1325-1332	Negative_regulation	denotes	lacking
T3577	1325-1332	Negative_regulation	denotes	lacking
T3578	1340-1344	Protein	denotes	PKD1
T3579	1348-1352	Protein	denotes	PKD3
T3580	1436-1445	Positive_regulation	denotes	increased
T3581	1460-1465	Protein	denotes	HSP27
T3582	1466-1481	Phosphorylation	denotes	phosphorylation
T3583	1485-1488	Entity	denotes	S82
T3584	1564-1572	Positive_regulation	denotes	increase
T3585	1573-1578	Protein	denotes	HSP27
T3586	1579-1594	Phosphorylation	denotes	phosphorylation
T3587	1598-1602	Protein	denotes	PKD1
T3588	1606-1610	Protein	denotes	PKD3
T3589	1618-1626	Negative_regulation	denotes	knockout
T3590	1618-1626	Negative_regulation	denotes	knockout
T3591	1683-1690	Positive_regulation	denotes	induced
T3592	1691-1706	Phosphorylation	denotes	phosphorylation
T3593	1710-1715	Protein	denotes	HSP27
T3594	1719-1722	Entity	denotes	S82
T3595	1727-1736	Negative_regulation	denotes	abolished
T3596	1727-1736	Negative_regulation	denotes	abolished
T3597	1753-1759	Negative_regulation	denotes	lacked
T3598	1753-1759	Negative_regulation	denotes	lacked
T3599	1765-1769	Protein	denotes	PKD1
T3600	1774-1778	Protein	denotes	PKD3
T3601	1817-1824	Positive_regulation	denotes	induced
T3602	1825-1835	Gene_expression	denotes	expression
T3603	1848-1852	Protein	denotes	PKD3
T3604	1896-1917	Positive_regulation	denotes	sufficient to restore
T3605	1925-1935	Regulation	denotes	regulation
T3606	1939-1944	Protein	denotes	HSP27
T3607	1945-1960	Phosphorylation	denotes	phosphorylation
T3608	1985-1995	Gene_expression	denotes	expression
T3609	2008-2017	Negative_regulation	denotes	deficient
T3610	2018-2022	Protein	denotes	PKD3
T3611	2083-2090	Positive_regulation	denotes	restore	true
T3612	2113-2120	Positive_regulation	denotes	induced
T3613	2121-2126	Protein	denotes	HSP27
T3614	2127-2142	Phosphorylation	denotes	phosphorylation
T3615	2161-2165	Protein	denotes	PKD3
T3616	2177-2181	Protein	denotes	PKD1
T3617	2186-2194	Regulation	denotes	regulate
T3618	2186-2194	Regulation	denotes	regulate
T3619	2195-2200	Protein	denotes	HSP27
T3620	2201-2216	Phosphorylation	denotes	phosphorylation
T3621	2272-2277	Protein	denotes	HSP27
T4751	2652-2656	Protein	denotes	PKD1
T4752	2657-2658	Protein	denotes	3
T4753	2668-2672	Protein	denotes	PKD3
T4754	2689-2693	Protein	denotes	PKD1
T4755	2694-2695	Protein	denotes	3
T4756	2770-2774	Protein	denotes	PKD1
T4757	2775-2776	Protein	denotes	3
T4758	2817-2830	Gene_expression	denotes	re-expression
T4759	2839-2843	Protein	denotes	PKD3
T4760	2933-2937	Protein	denotes	PKD1
T4761	2938-2939	Protein	denotes	3
T4762	3107-3111	Protein	denotes	PKD1
T4763	3112-3113	Protein	denotes	3
T4764	3231-3235	Protein	denotes	PKD3
T4765	3236-3249	Gene_expression	denotes	re-expression
T4766	3286-3290	Protein	denotes	PKD1
T4767	3291-3292	Protein	denotes	3
T4768	3579-3583	Protein	denotes	PKD1
T4769	3588-3592	Protein	denotes	PKD2
T4770	3908-3912	Negative_regulation	denotes	loss
T4771	3908-3912	Negative_regulation	denotes	loss
T4772	3916-3920	Protein	denotes	PKD1
T4773	3921-3922	Protein	denotes	3
T4774	3923-3933	Gene_expression	denotes	expression
T4775	3923-3933	Gene_expression	denotes	expression
T6905	4742-4746	Protein	denotes	PKD1
T6906	4747-4748	Protein	denotes	3
T6907	4760-4764	Protein	denotes	PKD1
T6908	4765-4766	Protein	denotes	3
T6909	4775-4779	Protein	denotes	PKD3
T6910	4889-4893	Protein	denotes	PKD1
T6911	4894-4895	Protein	denotes	3
T6912	5047-5054	Positive_regulation	denotes	induced
T6913	5047-5054	Positive_regulation	denotes	induced
T6914	5047-5054	Positive_regulation	denotes	induced
T6915	5055-5065	Positive_regulation	denotes	activation
T6916	5055-5065	Positive_regulation	denotes	activation
T6917	5055-5065	Positive_regulation	denotes	activation
T6918	5073-5076	Protein	denotes	Akt
T6919	5078-5082	Protein	denotes	mTOR
T6920	5110-5130	Protein	denotes	S6 ribosomal protein
T6921	5131-5146	Phosphorylation	denotes	phosphorylation
T6922	5189-5199	Negative_regulation	denotes	detectable	true
T6923	5189-5199	Negative_regulation	denotes	detectable	true
T6924	5189-5199	Negative_regulation	denotes	detectable	true
T6925	5189-5199	Negative_regulation	denotes	detectable	true
T6926	5189-5199	Negative_regulation	denotes	detectable	true
T6927	5189-5199	Negative_regulation	denotes	detectable	true
T6928	5203-5207	Protein	denotes	PKD1
T6929	5208-5209	Protein	denotes	3
T6930	5210-5214	Negative_regulation	denotes	null
T6931	5210-5214	Negative_regulation	denotes	null
T6932	5413-5417	Protein	denotes	PKD1
T6933	5418-5419	Protein	denotes	3
T6934	5541-5545	Protein	denotes	Erk1
T6935	5546-5550	Protein	denotes	RSK1
T6942	6034-6035	Protein	denotes	3
T6943	6044-6048	Protein	denotes	PKD1
T3540	17-21	Negative_regulation	denotes	Loss		true
T3541	25-30	Protein	denotes	HSP27
T3542	31-46	Phosphorylation	denotes	phosphorylation
T3543	117-124	Gene_expression	denotes	express
T3544	117-124	Gene_expression	denotes	express
T3545	143-147	Protein	denotes	PKD1
T3546	152-156	Protein	denotes	PKD3
T3547	236-240	Negative_regulation	denotes	lack
T3548	236-240	Negative_regulation	denotes	lack
T3549	241-251	Gene_expression	denotes	expression
T3550	241-251	Gene_expression	denotes	expression
T3551	262-266	Protein	denotes	PKD1
T3552	270-274	Protein	denotes	PKD3
T3553	357-361	Protein	denotes	PKD1
T3554	372-376	Protein	denotes	PKD3
T3555	395-404	Gene_expression	denotes	expressed
T3556	412-416	Protein	denotes	PKD3
T3557	526-530	Protein	denotes	PKD3
T3558	531-541	Gene_expression	denotes	expression
T3559	545-549	Protein	denotes	PKD1
T3560	550-551	Protein	denotes	3
T3561	552-567	Negative_regulation	denotes	double knockout
T3562	552-567	Negative_regulation	denotes	double knockout
T6936	5585-5589	Protein	denotes	PKD1
T6937	5590-5591	Protein	denotes	3
T6938	5930-5934	Protein	denotes	PKD1
T6939	5935-5936	Protein	denotes	3
T6940	5945-5949	Protein	denotes	PKD3
T6941	6029-6033	Protein	denotes	PKD1
T6944	6049-6050	Protein	denotes	3
T6945	6059-6063	Protein	denotes	PKD3
T6946	6253-6257	Protein	denotes	PKD1
T6947	6258-6259	Protein	denotes	3
T6948	6566-6570	Protein	denotes	PKD1
T6949	6571-6572	Protein	denotes	3
T6950	6671-6675	Protein	denotes	PKD1
T6951	6676-6677	Protein	denotes	3
T6952	6847-6851	Negative_regulation	denotes	loss
T6953	6847-6851	Negative_regulation	denotes	loss
T6954	6855-6859	Protein	denotes	PKD1
T6955	6860-6861	Protein	denotes	3
T6956	7096-7104	Protein	denotes	MAPKAPK2
T6957	7720-7736	Protein	denotes	Bcr-Abl oncogene
T6958	7768-7794	Positive_regulation	denotes	expression of an activated
T6959	7795-7799	Protein	denotes	PKD1
T6960	7816-7820	Protein	denotes	HPK1
T6961	7906-7910	Protein	denotes	PKCβ
T6962	8104-8108	Protein	denotes	PKD1
T6963	8109-8110	Protein	denotes	3
T6964	8273-8278	Protein	denotes	PKCβ−
T6965	8363-8382	Phosphorylation	denotes	autophosphorylation
T6966	8386-8390	Protein	denotes	PKD1
T6967	8394-8398	Entity	denotes	S916
T6968	8404-8412	Positive_regulation	denotes	observed
T6969	8420-8425	Protein	denotes	PKCβ−
R2918	T3541	T3542	themeOf	HSP27,phosphorylation
R2925	T3542	T3540	themeOf	phosphorylation,Loss
R2926	T3545	T3543	themeOf	PKD1,express
R2927	T3546	T3544	themeOf	PKD3,express
R2929	T3550	T3548	themeOf	expression,lack
R2930	T3551	T3550	themeOf	PKD1,expression
R2941	T3587	T3590	themeOf	PKD1,knockout
R2942	T3588	T3589	themeOf	PKD3,knockout
R2944	T3591	T3595	themeOf	induced,abolished
R2945	T3591	T3596	themeOf	induced,abolished
R2946	T3592	T3591	themeOf	phosphorylation,induced
R2948	T3594	T3592	themeOf	S82,phosphorylation
R2949	T3594	T3593	partOf	S82,HSP27
R2950	T3597	T3596	causeOf	lacked,abolished
R2951	T3598	T3595	causeOf	lacked,abolished
R2952	T3599	T3598	themeOf	PKD1,lacked
R2953	T3600	T3597	themeOf	PKD3,lacked
R2954	T3601	T3604	causeOf	induced,sufficient to restore
R2955	T3602	T3601	themeOf	expression,induced
R2957	T3603	T3602	themeOf	PKD3,expression
R2958	T3605	T3604	themeOf	regulation,sufficient to restore
R2959	T3606	T3607	themeOf	HSP27,phosphorylation
R2960	T3607	T3605	themeOf	phosphorylation,regulation
R2962	T3608	T3611	causeOf	expression,restore
R2963	T3610	T3608	themeOf	PKD3,expression
R2964	T3610	T3609	themeOf	PKD3,deficient
R2966	T3612	T3611	themeOf	induced,restore
R2967	T3613	T3614	themeOf	HSP27,phosphorylation
R2968	T3614	T3612	themeOf	phosphorylation,induced
R2969	T3615	T3618	causeOf	PKD3,regulate
R2971	T3616	T3617	causeOf	PKD1,regulate
R2973	T3619	T3620	themeOf	HSP27,phosphorylation
R2974	T3620	T3618	themeOf	phosphorylation,regulate
R2975	T3620	T3617	themeOf	phosphorylation,regulate
R3843	T4759	T4758	themeOf	PKD3,re-expression
R3844	T4764	T4765	themeOf	PKD3,re-expression
R3845	T4772	T4774	themeOf	PKD1,expression
R3846	T4773	T4775	themeOf	3,expression
R3847	T4774	T4771	themeOf	expression,loss
R3848	T4775	T4770	themeOf	expression,loss
R5508	T6931	T6926	causeOf	null,detectable
R5509	T6965	T6968	themeOf	autophosphorylation,observed
R5510	T6967	T6965	themeOf	S916,autophosphorylation
R5511	T6967	T6966	partOf	S916,PKD1
R2928	T3549	T3547	themeOf	expression,lack
R2931	T3579	T3577	themeOf	PKD3,lacking
R2932	T3552	T3549	themeOf	PKD3,expression
R2933	T3582	T3580	themeOf	phosphorylation,increased
R2934	T3556	T3555	themeOf	PKD3,expressed
R2935	T3583	T3582	themeOf	S82,phosphorylation
R2936	T3583	T3581	partOf	S82,HSP27
R2937	T3585	T3586	themeOf	HSP27,phosphorylation
R2938	T3586	T3584	themeOf	phosphorylation,increase
R2939	T3557	T3558	themeOf	PKD3,expression
R2940	T3559	T3562	themeOf	PKD1,double knockout
R2943	T3560	T3561	themeOf	3,double knockout
R2947	T3569	T3568	themeOf	phosphorylation,defective
R2956	T3571	T3569	themeOf	serine 82,phosphorylation
R2961	T3571	T3570	partOf	serine 82,HSP27
R2965	T3574	T3575	themeOf	HSP27,phosphorylation
R2970	T3575	T3573	themeOf	phosphorylation,regulation
R2972	T3578	T3576	themeOf	PKD1,lacking
R5479	T6912	T6922	themeOf	induced,detectable
R5486	T6912	T6924	themeOf	induced,detectable
R5487	T6913	T6927	themeOf	induced,detectable
R5488	T6913	T6926	themeOf	induced,detectable
R5489	T6914	T6923	themeOf	induced,detectable
R5490	T6914	T6925	themeOf	induced,detectable
R5491	T6915	T6914	themeOf	activation,induced
R5492	T6916	T6912	themeOf	activation,induced
R5493	T6917	T6913	themeOf	activation,induced
R5494	T6918	T6917	themeOf	Akt,activation
R5495	T6919	T6916	themeOf	mTOR,activation
R5496	T6920	T6921	themeOf	S6 ribosomal protein,phosphorylation
R5497	T6921	T6915	themeOf	phosphorylation,activation
R5498	T6928	T6931	themeOf	PKD1,null
R5499	T6929	T6930	themeOf	3,null
R5500	T6930	T6927	causeOf	null,detectable
R5501	T6954	T6953	themeOf	PKD1,loss
R5502	T6930	T6924	causeOf	null,detectable
R5503	T6930	T6925	causeOf	null,detectable
R5504	T6955	T6952	themeOf	3,loss
R5505	T6931	T6922	causeOf	null,detectable
R5506	T6931	T6923	causeOf	null,detectable
R5507	T6959	T6958	themeOf	PKD1,expression of an activated

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T3622	25-30	Protein	denotes	HSP27
T3623	50-56	Protein	denotes	DT40 B
T3624	85-95	Protein	denotes	PKD family
T3625	31-46	Phosphorylation	denotes	phosphorylation
T3626	71-81	Gene_expression	denotes	expression
T3628	63-70	Negative_regulation	denotes	lacking
T3629	104-110	Protein	denotes	DT40 B
T3630	129-132	Protein	denotes	PKD
T3631	143-147	Protein	denotes	PKD1
T3632	152-156	Protein	denotes	PKD3
T3633	262-266	Protein	denotes	PKD1
T3634	270-274	Protein	denotes	PKD3
T3635	117-124	Gene_expression	denotes	express
T3636	117-124	Gene_expression	denotes	express
T3637	117-124	Gene_expression	denotes	express
T3638	241-251	Gene_expression	denotes	expression
T3639	241-251	Gene_expression	denotes	expression
T3640	236-240	Negative_regulation	denotes	lack
T3641	236-240	Negative_regulation	denotes	lack
T3642	357-366	Protein	denotes	PKD1 loci
T3643	372-376	Protein	denotes	PKD3
T3644	407-411	Protein	denotes	Flag
T3645	412-416	Protein	denotes	PKD3
T3646	395-404	Gene_expression	denotes	expressed
T3647	395-404	Gene_expression	denotes	expressed
T3648	521-525	Protein	denotes	Flag
T3649	526-530	Protein	denotes	PKD3
T3650	545-551	Protein	denotes	PKD1/3
T3651	602-606	Protein	denotes	PKD3
T3652	531-541	Gene_expression	denotes	expression
T3653	531-541	Gene_expression	denotes	expression
T3654	833-862	Protein	denotes	class II histone deacetylases
T3655	864-869	Protein	denotes	HDACs
T3656	878-881	Protein	denotes	BCR
T3657	909-913	Protein	denotes	PKD1
T3658	792-807	Phosphorylation	denotes	phosphorylation
T3659	792-807	Phosphorylation	denotes	phosphorylation
T3660	882-892	Binding	denotes	engagement
T3661	935-943	Positive_regulation	denotes	restored
T3662	935-943	Positive_regulation	denotes	restored
T3663	996-1020	Protein	denotes	small heat shock protein
T3664	1021-1026	Protein	denotes	HSP27
T3665	1059-1063	Protein	denotes	PKD1
T3666	1115-1118	Protein	denotes	PKD
T3667	1169-1174	Protein	denotes	HSP27
T3668	1202-1206	Protein	denotes	PKD1
T3669	1178-1184	Entity	denotes	serine
T3670	1150-1165	Phosphorylation	denotes	phosphorylation
T3671	1140-1149	Negative_regulation	denotes	defective
T3672	1271-1276	Protein	denotes	HSP27
T3673	1340-1344	Protein	denotes	PKD1
T3675	1277-1292	Phosphorylation	denotes	phosphorylation
T3676	1325-1332	Negative_regulation	denotes	lacking
T3677	1325-1332	Negative_regulation	denotes	lacking
T3678	1257-1267	Regulation	denotes	regulation
T3679	1366-1369	Protein	denotes	Fig
T3680	1393-1396	Protein	denotes	BCR
T3681	1460-1465	Protein	denotes	HSP27
T3682	1375-1385	Positive_regulation	denotes	activation
T3683	1436-1445	Positive_regulation	denotes	increased
T3684	1466-1481	Phosphorylation	denotes	phosphorylation
T3685	1516-1519	Protein	denotes	BCR
T3686	1573-1578	Protein	denotes	HSP27
T3687	1598-1602	Protein	denotes	PKD1
T3688	1606-1610	Protein	denotes	PKD3
T3689	1579-1594	Phosphorylation	denotes	phosphorylation
T3690	1618-1626	Negative_regulation	denotes	knockout
T3691	1618-1626	Negative_regulation	denotes	knockout
T3692	1564-1572	Positive_regulation	denotes	increase
T3693	1660-1663	Protein	denotes	BCR
T3694	1710-1715	Protein	denotes	HSP27
T3695	1765-1769	Protein	denotes	PKD1
T3696	1774-1778	Protein	denotes	PKD3
T3697	1780-1787	Protein	denotes	Fig. 1C
T3698	1719-1722	Entity	denotes	S82
T3699	1753-1759	Negative_regulation	denotes	lacked
T3700	1753-1759	Negative_regulation	denotes	lacked
T3701	1753-1759	Negative_regulation	denotes	lacked
T3702	1691-1706	Phosphorylation	denotes	phosphorylation
T3703	1691-1706	Phosphorylation	denotes	phosphorylation
T3704	1727-1736	Negative_regulation	denotes	abolished
T3705	1727-1736	Negative_regulation	denotes	abolished
T3706	1843-1847	Protein	denotes	Flag
T3707	1848-1852	Protein	denotes	PKD3
T3708	1939-1944	Protein	denotes	HSP27
T3709	1825-1835	Gene_expression	denotes	expression
T3710	1825-1835	Gene_expression	denotes	expression
T3711	1945-1960	Phosphorylation	denotes	phosphorylation
T3712	1805-1824	Positive_regulation	denotes	doxycycline-induced
T3713	1805-1824	Positive_regulation	denotes	doxycycline-induced
T3714	1925-1935	Regulation	denotes	regulation
T3715	1910-1917	Positive_regulation	denotes	restore
T3716	2018-2022	Protein	denotes	PKD3
T3717	2121-2126	Protein	denotes	HSP27
T3718	1985-1995	Gene_expression	denotes	expression
T3719	2001-2017	Negative_regulation	denotes	kinase-deficient
T3720	2127-2142	Phosphorylation	denotes	phosphorylation
T3721	2083-2090	Positive_regulation	denotes	restore
T3722	2107-2120	Positive_regulation	denotes	ester-induced
T3723	2161-2165	Protein	denotes	PKD3
T3724	2177-2181	Protein	denotes	PKD1
T3725	2195-2200	Protein	denotes	HSP27
T3726	2272-2285	Protein	denotes	HSP27 kinases
T3727	2201-2216	Phosphorylation	denotes	phosphorylation
T3728	2186-2194	Regulation	denotes	regulate
T3729	2186-2194	Regulation	denotes	regulate
T4793	2933-2937	Protein	denotes	PKD1
T4794	3107-3111	Protein	denotes	PKD1
T4795	3231-3235	Protein	denotes	PKD3
T4796	3286-3290	Protein	denotes	PKD1
T4797	3432-3443	Protein	denotes	PKD enzymes
T4798	3236-3249	Gene_expression	denotes	re-expression
T4799	3424-3428	Negative_regulation	denotes	loss
T4800	3451-3469	Protein	denotes	PKD family enzymes
T4801	3539-3545	Protein	denotes	DT40 B
T4802	3553-3564	Protein	denotes	PKD enzymes
T4803	3579-3583	Protein	denotes	PKD1
T4804	3588-3592	Protein	denotes	PKD2
T4805	3780-3798	Protein	denotes	PKD family kinases
T4806	3899-3902	Protein	denotes	Fig
T4807	3916-3920	Protein	denotes	PKD1
T4808	3921-3922	Protein	denotes	3
T4809	3979-3985	Protein	denotes	DT40 B
T4810	4264-4274	Protein	denotes	I/II HDACs
T4811	3923-3933	Gene_expression	denotes	expression
T4812	3923-3933	Gene_expression	denotes	expression
T4813	4245-4254	Negative_regulation	denotes	inhibitor
T4814	3908-3912	Negative_regulation	denotes	loss
T4815	3908-3912	Negative_regulation	denotes	loss
T4816	4282-4293	Protein	denotes	PKD kinases
T4776	2367-2377	Protein	denotes	PKD family
T4777	2353-2363	Gene_expression	denotes	expression
T4778	2345-2352	Negative_regulation	denotes	lacking
T4779	2386-2389	Protein	denotes	PKD
T4780	2538-2549	Protein	denotes	PKD kinases
T4781	2620-2623	Protein	denotes	PKD
T4782	2652-2656	Protein	denotes	PKD1
T4783	2663-2667	Protein	denotes	Flag
T4784	2668-2672	Protein	denotes	PKD3
T4785	2689-2693	Protein	denotes	PKD1
T4786	2530-2534	Negative_regulation	denotes	loss
T4787	2761-2764	Protein	denotes	Fig
T4788	2770-2774	Protein	denotes	PKD1
T4789	2834-2838	Protein	denotes	Flag
T4790	2839-2843	Protein	denotes	PKD3
T4791	2817-2830	Gene_expression	denotes	re-expression
T4792	2817-2830	Gene_expression	denotes	re-expression
T3674	1348-1352	Protein	denotes	PKD3
R2977	T3626	T3628	themeOf	expression,lacking
R2978	T3630	T3635	themeOf	PKD,express
R2979	T3631	T3636	themeOf	PKD1,express
R2980	T3622	T3625	themeOf	HSP27,phosphorylation
R2981	T3632	T3637	themeOf	PKD3,express
R2982	T3624	T3626	themeOf	PKD family,expression
R2983	T3633	T3638	themeOf	PKD1,expression
R2984	T3634	T3639	themeOf	PKD3,expression
R2985	T3638	T3640	themeOf	expression,lack
R2986	T3674	T3677	themeOf	PKD3,lacking
R2987	T3675	T3678	themeOf	phosphorylation,regulation
R2988	T3639	T3641	themeOf	expression,lack
R2989	T3644	T3646	themeOf	Flag,expressed
R2990	T3680	T3682	themeOf	BCR,activation
R2991	T3681	T3684	themeOf	HSP27,phosphorylation
R2992	T3682	T3683	themeOf	activation,increased
R2993	T3686	T3689	themeOf	HSP27,phosphorylation
R2994	T3645	T3647	themeOf	PKD3,expressed
R2995	T3648	T3652	themeOf	Flag,expression
R2999	T3649	T3653	themeOf	PKD3,expression
R3001	T3654	T3658	themeOf	class II histone deacetylases,phosphorylation
R3003	T3694	T3703	themeOf	HSP27,phosphorylation
R3004	T3694	T3698	partOf	HSP27,S82
R3005	T3695	T3699	themeOf	PKD1,lacked
R3006	T3696	T3700	themeOf	PKD3,lacked
R3007	T3697	T3701	themeOf	Fig. 1C,lacked
R3008	T3698	T3702	Site	S82,phosphorylation
R3009	T3698	T3703	Site	S82,phosphorylation
R3010	T3655	T3659	themeOf	HDACs,phosphorylation
R3011	T3702	T3704	themeOf	phosphorylation,abolished
R3012	T3656	T3660	themeOf	BCR,engagement
R3013	T3703	T3705	themeOf	phosphorylation,abolished
R3014	T3706	T3709	themeOf	Flag,expression
R3015	T3707	T3710	themeOf	PKD3,expression
R3016	T3658	T3661	themeOf	phosphorylation,restored
R3017	T3708	T3711	themeOf	HSP27,phosphorylation
R3018	T3709	T3712	themeOf	expression,doxycycline-induced
R3019	T3659	T3662	themeOf	phosphorylation,restored
R3020	T3667	T3670	themeOf	HSP27,phosphorylation
R3021	T3710	T3713	themeOf	expression,doxycycline-induced
R3022	T3711	T3714	themeOf	phosphorylation,regulation
R3023	T3714	T3715	themeOf	regulation,restore
R3024	T3716	T3718	themeOf	PKD3,expression
R3025	T3717	T3720	themeOf	HSP27,phosphorylation
R3026	T3667	T3669	partOf	HSP27,serine
R3027	T3718	T3719	themeOf	expression,kinase-deficient
R3028	T3718	T3721	causeOf	expression,restore
R3029	T3668	T3669	partOf	PKD1,serine
R3030	T3720	T3721	themeOf	phosphorylation,restore
R3031	T3720	T3722	themeOf	phosphorylation,ester-induced
R3032	T3669	T3670	Site	serine,phosphorylation
R3033	T3723	T3728	causeOf	PKD3,regulate
R3034	T3670	T3671	themeOf	phosphorylation,defective
R3035	T3724	T3729	causeOf	PKD1,regulate
R3036	T3725	T3727	themeOf	HSP27,phosphorylation
R3037	T3672	T3675	themeOf	HSP27,phosphorylation
R3038	T3727	T3728	themeOf	phosphorylation,regulate
R3039	T3727	T3729	themeOf	phosphorylation,regulate
R3040	T3673	T3676	themeOf	PKD1,lacking
R3849	T4776	T4777	themeOf	PKD family,expression
R3850	T4777	T4778	themeOf	expression,lacking
R3851	T4780	T4786	themeOf	PKD kinases,loss
R3852	T4789	T4791	themeOf	Flag,re-expression
R3853	T4790	T4792	themeOf	PKD3,re-expression
R3854	T4795	T4798	themeOf	PKD3,re-expression
R3855	T4797	T4799	themeOf	PKD enzymes,loss
R3856	T4807	T4811	themeOf	PKD1,expression
R3857	T4808	T4812	themeOf	3,expression
R3858	T4810	T4813	themeOf	I/II HDACs,inhibitor
R3859	T4811	T4814	themeOf	expression,loss
R3860	T4812	T4815	themeOf	expression,loss
R2996	T3687	T3690	themeOf	PKD1,knockout
R2997	T3688	T3691	themeOf	PKD3,knockout
R2998	T3689	T3692	themeOf	phosphorylation,increase
R3000	T3693	T3702	themeOf	BCR,phosphorylation
R3002	T3693	T3698	partOf	BCR,S82

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T2250	2121-2126	Protein	denotes	HSP27
T2251	2127-2142	Phosphorylation	denotes	phosphorylation
T2252	2161-2165	Protein	denotes	PKD3
T2253	2177-2181	Protein	denotes	PKD1
T2254	2186-2194	Regulation	denotes	regulate
T2255	2186-2194	Regulation	denotes	regulate
T2256	2195-2200	Protein	denotes	HSP27
T2257	2201-2216	Phosphorylation	denotes	phosphorylation
T2258	2272-2277	Protein	denotes	HSP27
T4955	5073-5076	Protein	denotes	Akt
T4956	5078-5082	Protein	denotes	mTOR
T4957	5110-5130	Protein	denotes	S6 ribosomal protein
T4958	5131-5146	Phosphorylation	denotes	phosphorylation
T4959	5189-5199	Negative_regulation	denotes	detectable	true
T4960	5189-5199	Negative_regulation	denotes	detectable	true
T4961	5189-5199	Negative_regulation	denotes	detectable	true
T4962	5189-5199	Negative_regulation	denotes	detectable	true
T4963	5189-5199	Negative_regulation	denotes	detectable	true
T4964	5189-5199	Negative_regulation	denotes	detectable	true
T4965	5203-5207	Protein	denotes	PKD1
T4966	5208-5209	Protein	denotes	3
T4967	5210-5214	Negative_regulation	denotes	null
T4968	5210-5214	Negative_regulation	denotes	null
T4969	5413-5417	Protein	denotes	PKD1
T4970	5418-5419	Protein	denotes	3
T4971	5541-5545	Protein	denotes	Erk1
T4972	5546-5550	Protein	denotes	RSK1
T4973	5585-5589	Protein	denotes	PKD1
T4974	5590-5591	Protein	denotes	3
T4975	5930-5934	Protein	denotes	PKD1
T4976	5935-5936	Protein	denotes	3
T4977	5945-5949	Protein	denotes	PKD3
T4978	6029-6033	Protein	denotes	PKD1
T4979	6034-6035	Protein	denotes	3
T4980	6044-6048	Protein	denotes	PKD1
T4981	6049-6050	Protein	denotes	3
T4982	6059-6063	Protein	denotes	PKD3
T4983	6253-6257	Protein	denotes	PKD1
T4984	6258-6259	Protein	denotes	3
T4985	6566-6570	Protein	denotes	PKD1
T4986	6571-6572	Protein	denotes	3
T4987	6671-6675	Protein	denotes	PKD1
T4988	6676-6677	Protein	denotes	3
T4989	6847-6851	Negative_regulation	denotes	loss
T4990	6847-6851	Negative_regulation	denotes	loss
T4991	6855-6859	Protein	denotes	PKD1
T4992	6860-6861	Protein	denotes	3
T4993	7096-7104	Protein	denotes	MAPKAPK2
T4994	7720-7736	Protein	denotes	Bcr-Abl oncogene
T4995	7768-7794	Positive_regulation	denotes	expression of an activated
T4996	7795-7799	Protein	denotes	PKD1
T4997	7816-7820	Protein	denotes	HPK1
T4998	7906-7910	Protein	denotes	PKCβ
T4999	8104-8108	Protein	denotes	PKD1
T5000	8109-8110	Protein	denotes	3
T5001	8273-8278	Protein	denotes	PKCβ−
T5002	8363-8382	Phosphorylation	denotes	autophosphorylation
T5003	8386-8390	Protein	denotes	PKD1
T5004	8394-8398	Entity	denotes	S916
T5005	8404-8412	Positive_regulation	denotes	observed
T5006	8420-8425	Protein	denotes	PKCβ−
T2177	17-21	Negative_regulation	denotes	Loss		true
T2178	25-30	Protein	denotes	HSP27
T2179	31-46	Phosphorylation	denotes	phosphorylation
T2180	117-124	Gene_expression	denotes	express
T2181	117-124	Gene_expression	denotes	express
T2182	143-147	Protein	denotes	PKD1
T2183	152-156	Protein	denotes	PKD3
T2184	236-240	Negative_regulation	denotes	lack
T2185	236-240	Negative_regulation	denotes	lack
T2186	241-251	Gene_expression	denotes	expression
T2187	241-251	Gene_expression	denotes	expression
T2188	262-266	Protein	denotes	PKD1
T2189	270-274	Protein	denotes	PKD3
T2190	357-361	Protein	denotes	PKD1
T2191	372-376	Protein	denotes	PKD3
T2192	395-404	Gene_expression	denotes	expressed
T2193	412-416	Protein	denotes	PKD3
T2194	526-530	Protein	denotes	PKD3
T2195	531-541	Gene_expression	denotes	expression
T2196	545-549	Protein	denotes	PKD1
T2197	550-551	Protein	denotes	3
T2198	552-567	Negative_regulation	denotes	double knockout
T2199	552-567	Negative_regulation	denotes	double knockout
T2200	602-606	Protein	denotes	PKD3
T2201	909-913	Protein	denotes	PKD1
T2202	914-915	Protein	denotes	3
T2203	1021-1026	Protein	denotes	HSP27
T2204	1059-1063	Protein	denotes	PKD1
T2205	1140-1149	Negative_regulation	denotes	defective
T2206	1150-1165	Phosphorylation	denotes	phosphorylation
T2207	1169-1174	Protein	denotes	HSP27
T2208	1178-1187	Entity	denotes	serine 82
T2209	1202-1206	Protein	denotes	PKD1
T2210	1257-1267	Regulation	denotes	regulation		true
T2211	1271-1276	Protein	denotes	HSP27
T2212	1277-1292	Phosphorylation	denotes	phosphorylation
T2213	1325-1332	Negative_regulation	denotes	lacking
T2214	1325-1332	Negative_regulation	denotes	lacking
T2215	1340-1344	Protein	denotes	PKD1
T2216	1348-1352	Protein	denotes	PKD3
T2217	1436-1445	Positive_regulation	denotes	increased
T2218	1460-1465	Protein	denotes	HSP27
T2219	1466-1481	Phosphorylation	denotes	phosphorylation
T2220	1485-1488	Entity	denotes	S82
T2221	1564-1572	Positive_regulation	denotes	increase
T2222	1573-1578	Protein	denotes	HSP27
T2223	1579-1594	Phosphorylation	denotes	phosphorylation
T2224	1598-1602	Protein	denotes	PKD1
T2225	1606-1610	Protein	denotes	PKD3
T2226	1618-1626	Negative_regulation	denotes	knockout
T2227	1618-1626	Negative_regulation	denotes	knockout
T2228	1683-1690	Positive_regulation	denotes	induced
T2229	1691-1706	Phosphorylation	denotes	phosphorylation
T2230	1710-1715	Protein	denotes	HSP27
T2231	1719-1722	Entity	denotes	S82
T2232	1727-1736	Negative_regulation	denotes	abolished
T2233	1727-1736	Negative_regulation	denotes	abolished
T2234	1753-1759	Negative_regulation	denotes	lacked
T2235	1753-1759	Negative_regulation	denotes	lacked
T2236	1765-1769	Protein	denotes	PKD1
T2237	1774-1778	Protein	denotes	PKD3
T2238	1817-1824	Positive_regulation	denotes	induced
T2239	1825-1835	Gene_expression	denotes	expression
T2240	1848-1852	Protein	denotes	PKD3
T2241	1896-1917	Positive_regulation	denotes	sufficient to restore
T2242	1925-1935	Regulation	denotes	regulation
T2243	1939-1944	Protein	denotes	HSP27
T2244	1945-1960	Phosphorylation	denotes	phosphorylation
T2245	1985-1995	Gene_expression	denotes	expression
T2246	2008-2017	Negative_regulation	denotes	deficient
T2247	2018-2022	Protein	denotes	PKD3
T2248	2083-2090	Positive_regulation	denotes	restore	true
T2249	2113-2120	Positive_regulation	denotes	induced
T3783	2652-2656	Protein	denotes	PKD1
T3784	2657-2658	Protein	denotes	3
T3785	2668-2672	Protein	denotes	PKD3
T3786	2689-2693	Protein	denotes	PKD1
T3787	2694-2695	Protein	denotes	3
T3788	2770-2774	Protein	denotes	PKD1
T3789	2775-2776	Protein	denotes	3
T3790	2817-2830	Gene_expression	denotes	re-expression
T3791	2839-2843	Protein	denotes	PKD3
T3792	2933-2937	Protein	denotes	PKD1
T3793	2938-2939	Protein	denotes	3
T3794	3107-3111	Protein	denotes	PKD1
T3795	3112-3113	Protein	denotes	3
T3796	3231-3235	Protein	denotes	PKD3
T3797	3236-3249	Gene_expression	denotes	re-expression
T3798	3286-3290	Protein	denotes	PKD1
T3799	3291-3292	Protein	denotes	3
T3800	3579-3583	Protein	denotes	PKD1
T3801	3588-3592	Protein	denotes	PKD2
T3802	3908-3912	Negative_regulation	denotes	loss
T3803	3908-3912	Negative_regulation	denotes	loss
T3804	3916-3920	Protein	denotes	PKD1
T3805	3921-3922	Protein	denotes	3
T3806	3923-3933	Gene_expression	denotes	expression
T3807	3923-3933	Gene_expression	denotes	expression
T4942	4742-4746	Protein	denotes	PKD1
T4943	4747-4748	Protein	denotes	3
T4944	4760-4764	Protein	denotes	PKD1
T4945	4765-4766	Protein	denotes	3
T4946	4775-4779	Protein	denotes	PKD3
T4947	4889-4893	Protein	denotes	PKD1
T4948	4894-4895	Protein	denotes	3
T4949	5047-5054	Positive_regulation	denotes	induced
T4950	5047-5054	Positive_regulation	denotes	induced
T4951	5047-5054	Positive_regulation	denotes	induced
T4952	5055-5065	Positive_regulation	denotes	activation
T4953	5055-5065	Positive_regulation	denotes	activation
T4954	5055-5065	Positive_regulation	denotes	activation
R1883	T2253	T2254	causeOf	PKD1,regulate
R1884	T2256	T2257	themeOf	HSP27,phosphorylation
R1885	T2257	T2255	themeOf	phosphorylation,regulate
R1886	T2257	T2254	themeOf	phosphorylation,regulate
R1839	T2186	T2184	themeOf	expression,lack
R1842	T2189	T2186	themeOf	PKD3,expression
R1843	T2193	T2192	themeOf	PKD3,expressed
R1844	T2194	T2195	themeOf	PKD3,expression
R1845	T2196	T2199	themeOf	PKD1,double knockout
R1846	T2197	T2198	themeOf	3,double knockout
R1847	T2206	T2205	themeOf	phosphorylation,defective
R1848	T2208	T2206	themeOf	serine 82,phosphorylation
R1849	T2208	T2207	partOf	serine 82,HSP27
R1850	T2211	T2212	themeOf	HSP27,phosphorylation
R1851	T2212	T2210	themeOf	phosphorylation,regulation
R1852	T2215	T2213	themeOf	PKD1,lacking
R1853	T2216	T2214	themeOf	PKD3,lacking
R1854	T2219	T2217	themeOf	phosphorylation,increased
R1855	T2220	T2219	themeOf	S82,phosphorylation
R1856	T2220	T2218	partOf	S82,HSP27
R1857	T2222	T2223	themeOf	HSP27,phosphorylation
R1858	T2223	T2221	themeOf	phosphorylation,increase
R1835	T2178	T2179	themeOf	HSP27,phosphorylation
R1836	T2179	T2177	themeOf	phosphorylation,Loss
R1837	T2182	T2180	themeOf	PKD1,express
R1838	T2183	T2181	themeOf	PKD3,express
R1840	T2187	T2185	themeOf	expression,lack
R1841	T2188	T2187	themeOf	PKD1,expression
R1859	T2224	T2227	themeOf	PKD1,knockout
R1860	T2225	T2226	themeOf	PKD3,knockout
R1861	T2228	T2232	themeOf	induced,abolished
R1862	T2228	T2233	themeOf	induced,abolished
R1863	T2229	T2228	themeOf	phosphorylation,induced
R1864	T2231	T2229	themeOf	S82,phosphorylation
R1865	T2231	T2230	partOf	S82,HSP27
R1866	T2234	T2233	causeOf	lacked,abolished
R1867	T2235	T2232	causeOf	lacked,abolished
R1868	T2236	T2235	themeOf	PKD1,lacked
R1869	T2237	T2234	themeOf	PKD3,lacked
R1870	T2238	T2241	causeOf	induced,sufficient to restore
R1871	T2239	T2238	themeOf	expression,induced
R1872	T2240	T2239	themeOf	PKD3,expression
R1873	T2242	T2241	themeOf	regulation,sufficient to restore
R1874	T2243	T2244	themeOf	HSP27,phosphorylation
R1875	T2244	T2242	themeOf	phosphorylation,regulation
R1876	T2245	T2248	causeOf	expression,restore
R1877	T2247	T2245	themeOf	PKD3,expression
R1878	T2247	T2246	themeOf	PKD3,deficient
R1879	T2249	T2248	themeOf	induced,restore
R1880	T2250	T2251	themeOf	HSP27,phosphorylation
R1881	T2251	T2249	themeOf	phosphorylation,induced
R1882	T2252	T2255	causeOf	PKD3,regulate
R3050	T3791	T3790	themeOf	PKD3,re-expression
R3051	T3796	T3797	themeOf	PKD3,re-expression
R3052	T3804	T3806	themeOf	PKD1,expression
R3053	T3805	T3807	themeOf	3,expression
R3054	T3806	T3803	themeOf	expression,loss
R3055	T3807	T3802	themeOf	expression,loss
R3904	T4949	T4959	themeOf	induced,detectable
R3905	T4949	T4961	themeOf	induced,detectable
R3906	T4950	T4964	themeOf	induced,detectable
R3907	T4950	T4963	themeOf	induced,detectable
R3908	T4951	T4960	themeOf	induced,detectable
R3909	T4951	T4962	themeOf	induced,detectable
R3910	T4952	T4951	themeOf	activation,induced
R3911	T4953	T4949	themeOf	activation,induced
R3912	T4954	T4950	themeOf	activation,induced
R3913	T4955	T4954	themeOf	Akt,activation
R3914	T4956	T4953	themeOf	mTOR,activation
R3915	T4957	T4958	themeOf	S6 ribosomal protein,phosphorylation
R3916	T4958	T4952	themeOf	phosphorylation,activation
R3917	T4965	T4968	themeOf	PKD1,null
R3918	T4966	T4967	themeOf	3,null
R3919	T4967	T4964	causeOf	null,detectable
R3920	T4967	T4961	causeOf	null,detectable
R3921	T4967	T4962	causeOf	null,detectable
R3922	T4968	T4959	causeOf	null,detectable
R3923	T4968	T4960	causeOf	null,detectable
R3924	T4968	T4963	causeOf	null,detectable
R3925	T4991	T4990	themeOf	PKD1,loss
R3926	T4992	T4989	themeOf	3,loss
R3927	T4996	T4995	themeOf	PKD1,expression of an activated
R3928	T5002	T5005	themeOf	autophosphorylation,observed
R3929	T5004	T5002	themeOf	S916,autophosphorylation
R3930	T5004	T5003	partOf	S916,PKD1

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T2676	25-30	P04792	denotes	HSP27
T2677	143-147	P98161	denotes	PKD1
T2678	152-156	Q99853	denotes	PKD3
T2679	262-266	P98161	denotes	PKD1
T2680	270-274	Q99853	denotes	PKD3
T2681	357-361	P98161	denotes	PKD1
T2682	372-376	Q99853	denotes	PKD3
T2683	412-416	Q99853	denotes	PKD3
T2684	526-530	Q99853	denotes	PKD3
T2685	545-549	P98161	denotes	PKD1
T2686	602-606	Q99853	denotes	PKD3
T2687	878-881	P11274	denotes	BCR
T2688	909-913	P98161	denotes	PKD1
T2689	1021-1026	P04792	denotes	HSP27
T2690	1059-1063	P98161	denotes	PKD1
T2691	1169-1174	P04792	denotes	HSP27
T2692	1202-1206	P98161	denotes	PKD1
T2693	1271-1276	P04792	denotes	HSP27
T4193	2652-2656	P98161	denotes	PKD1
T4194	2668-2672	Q99853	denotes	PKD3
T4195	2689-2693	P98161	denotes	PKD1
T4196	2770-2774	P98161	denotes	PKD1
T4197	2839-2843	Q99853	denotes	PKD3
T4198	2933-2937	P98161	denotes	PKD1
T4199	3107-3111	P98161	denotes	PKD1
T4200	3231-3235	Q99853	denotes	PKD3
T4201	3286-3290	P98161	denotes	PKD1
T4202	3579-3583	P98161	denotes	PKD1
T4203	3916-3920	P98161	denotes	PKD1
T4204	4113-4115	P03372	denotes	ER
T5705	4591-4594	P11274	denotes	BCR
T5706	4723-4726	P11274	denotes	BCR
T5707	4742-4746	P98161	denotes	PKD1
T5708	4760-4764	P98161	denotes	PKD1
T5709	4775-4779	Q99853	denotes	PKD3
T5710	4869-4872	P11274	denotes	BCR
T5711	4889-4893	P98161	denotes	PKD1
T5712	5043-5046	P11274	denotes	BCR
T5713	5073-5076	P31751	denotes	Akt
T5714	5073-5076	Q9Y243	denotes	Akt
T5715	5073-5076	P31749	denotes	Akt
T5716	5078-5082	P42345	denotes	mTOR
T5717	5203-5207	P98161	denotes	PKD1
T5718	5394-5397	P11274	denotes	BCR
T5719	5413-5417	P98161	denotes	PKD1
T5720	5487-5490	P11274	denotes	BCR
T5721	5541-5545	P27361	denotes	Erk1
T5722	5585-5589	P98161	denotes	PKD1
T5723	5878-5881	P11274	denotes	BCR
T5724	5930-5934	P98161	denotes	PKD1
T5725	5945-5949	Q99853	denotes	PKD3
T5726	6000-6003	P11274	denotes	BCR
T5727	6029-6033	P98161	denotes	PKD1
T5728	6044-6048	P98161	denotes	PKD1
T5729	6059-6063	Q99853	denotes	PKD3
T5730	6253-6257	P98161	denotes	PKD1
T5731	6452-6455	P11274	denotes	BCR
T5732	6566-6570	P98161	denotes	PKD1
T5733	6671-6675	P98161	denotes	PKD1
T5734	6855-6859	P98161	denotes	PKD1
T5735	7274-7277	P11274	denotes	BCR
T5736	7720-7723	P11274	denotes	Bcr
T5737	7724-7727	P00519	denotes	Abl
T5738	7795-7799	P98161	denotes	PKD1
T5739	8104-8108	P98161	denotes	PKD1
T5740	8166-8169	P11274	denotes	BCR
T5741	8196-8199	P11274	denotes	BCR
T5742	8386-8390	P98161	denotes	PKD1
T5743	8511-8514	P11274	denotes	BCR
T2694	1340-1344	P98161	denotes	PKD1
T2695	1348-1352	Q99853	denotes	PKD3
T2696	1393-1396	P11274	denotes	BCR
T2697	1460-1465	P04792	denotes	HSP27
T2698	1516-1519	P11274	denotes	BCR
T2699	1556-1560	P00519	denotes	able
T2700	1573-1578	P04792	denotes	HSP27
T2701	1598-1602	P98161	denotes	PKD1
T2702	1606-1610	Q99853	denotes	PKD3
T2703	1660-1663	P11274	denotes	BCR
T2704	1710-1715	P04792	denotes	HSP27
T2705	1765-1769	P98161	denotes	PKD1
T2706	1774-1778	Q99853	denotes	PKD3
T2707	1848-1852	Q99853	denotes	PKD3
T2708	1939-1944	P04792	denotes	HSP27
T2709	2018-2022	Q99853	denotes	PKD3
T2710	2075-2079	P00519	denotes	able
T2711	2091-2094	P11274	denotes	BCR
T2712	2121-2126	P04792	denotes	HSP27
T2713	2161-2165	Q99853	denotes	PKD3
T2714	2177-2181	P98161	denotes	PKD1
T2715	2195-2200	P04792	denotes	HSP27
T2716	2272-2277	P04792	denotes	HSP27

test2

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T3755	2652-2656	Protein	denotes	PKD1
T3756	2657-2658	Protein	denotes	3
T2103	25-30	Protein	denotes	HSP27		true
T2104	31-46	Phosphorylation	denotes	phosphorylation
T2105	117-124	Gene_expression	denotes	express
T2106	143-147	Protein	denotes	PKD1
T2107	152-156	Protein	denotes	PKD3
T2108	236-240	Negative_regulation	denotes	lack
T2109	241-251	Gene_expression	denotes	expression
T2110	262-266	Protein	denotes	PKD1
T2111	270-274	Protein	denotes	PKD3
T2112	357-361	Protein	denotes	PKD1
T2113	372-376	Protein	denotes	PKD3
T2114	395-404	Gene_expression	denotes	expressed
T2115	412-416	Protein	denotes	PKD3
T2116	526-530	Protein	denotes	PKD3
T2117	531-541	Gene_expression	denotes	expression		true
T2118	545-549	Protein	denotes	PKD1
T2119	550-551	Protein	denotes	3
T2120	559-567	Negative_regulation	denotes	knockout
T2121	602-606	Protein	denotes	PKD3
T2122	909-913	Protein	denotes	PKD1
T2123	914-915	Protein	denotes	3
T2124	1021-1026	Protein	denotes	HSP27
T2125	1059-1063	Protein	denotes	PKD1
T2126	1140-1149	Negative_regulation	denotes	defective
T2127	1150-1165	Phosphorylation	denotes	phosphorylation
T2128	1169-1174	Protein	denotes	HSP27
T2129	1178-1184	Entity	denotes	serine
T2130	1202-1206	Protein	denotes	PKD1
T2131	1257-1267	Regulation	denotes	regulation
T2132	1271-1276	Protein	denotes	HSP27
T2133	1277-1292	Phosphorylation	denotes	phosphorylation
T2134	1303-1311	Negative_regulation	denotes	knockout
T2135	1325-1332	Negative_regulation	denotes	lacking
T2136	1340-1344	Protein	denotes	PKD1
T2137	1348-1352	Protein	denotes	PKD3
T2138	1436-1445	Positive_regulation	denotes	increased
T2139	1460-1465	Protein	denotes	HSP27
T2140	1466-1481	Phosphorylation	denotes	phosphorylation	true
T2141	1485-1488	Entity	denotes	S82
T2142	1564-1572	Positive_regulation	denotes	increase
T2143	1573-1578	Protein	denotes	HSP27
T2144	1579-1594	Phosphorylation	denotes	phosphorylation
T2145	1598-1602	Protein	denotes	PKD1
T2146	1606-1610	Protein	denotes	PKD3
T2147	1618-1626	Negative_regulation	denotes	knockout
T2148	1683-1690	Positive_regulation	denotes	induced
T2149	1691-1706	Phosphorylation	denotes	phosphorylation
T2150	1710-1715	Protein	denotes	HSP27
T2151	1719-1722	Entity	denotes	S82
T2152	1727-1736	Negative_regulation	denotes	abolished
T2153	1753-1759	Negative_regulation	denotes	lacked
T2154	1765-1769	Protein	denotes	PKD1
T2155	1774-1778	Protein	denotes	PKD3
T2156	1817-1824	Positive_regulation	denotes	induced
T2157	1825-1835	Gene_expression	denotes	expression
T2158	1848-1852	Protein	denotes	PKD3
T2159	1925-1935	Regulation	denotes	regulation
T2160	1939-1944	Protein	denotes	HSP27
T2161	1945-1960	Phosphorylation	denotes	phosphorylation
T2162	1985-1995	Gene_expression	denotes	expression
T2163	2001-2007	Negative_regulation	denotes	kinase
T2164	2008-2017	Negative_regulation	denotes	deficient
T2165	2018-2022	Protein	denotes	PKD3
T2166	2083-2090	Positive_regulation	denotes	restore
T2167	2113-2120	Positive_regulation	denotes	induced
T2168	2121-2126	Protein	denotes	HSP27
T2169	2127-2142	Phosphorylation	denotes	phosphorylation
T2170	2161-2165	Protein	denotes	PKD3
T2171	2177-2181	Protein	denotes	PKD1
T2172	2186-2194	Regulation	denotes	regulate
T2173	2195-2200	Protein	denotes	HSP27
T2174	2201-2216	Phosphorylation	denotes	phosphorylation
T2175	2259-2268	Negative_regulation	denotes	redundant
T2176	2272-2277	Protein	denotes	HSP27
T3757	2668-2672	Protein	denotes	PKD3
T3758	2689-2693	Protein	denotes	PKD1
T3759	2694-2695	Protein	denotes	3
T3760	2770-2774	Protein	denotes	PKD1
T3761	2775-2776	Protein	denotes	3
T3762	2817-2819	Positive_regulation	denotes	re
T3763	2819-2820	Gene_expression	denotes	-
T3764	2820-2830	Gene_expression	denotes	expression
T3765	2839-2843	Protein	denotes	PKD3
T3766	2933-2937	Protein	denotes	PKD1
T3767	2938-2939	Protein	denotes	3
T3768	3107-3111	Protein	denotes	PKD1
T3769	3112-3113	Protein	denotes	3
T3770	3231-3235	Protein	denotes	PKD3
T3771	3236-3239	Gene_expression	denotes	re-
T3772	3239-3249	Gene_expression	denotes	expression
T3773	3286-3290	Protein	denotes	PKD1
T3774	3291-3292	Protein	denotes	3
T3775	3579-3583	Protein	denotes	PKD1
T3776	3588-3592	Protein	denotes	PKD2
T3777	3908-3912	Negative_regulation	denotes	loss
T3778	3916-3920	Protein	denotes	PKD1
T3779	3921-3922	Protein	denotes	3
T3780	3923-3933	Gene_expression	denotes	expression
T3781	4245-4254	Negative_regulation	denotes	inhibitor
T4882	4705-4715	Gene_expression	denotes	expression
T4883	4731-4738	Negative_regulation	denotes	reduced
T4884	4742-4746	Protein	denotes	PKD1
T4885	4747-4748	Protein	denotes	3
T4886	4760-4764	Protein	denotes	PKD1
T4887	4765-4766	Protein	denotes	3
T4888	4775-4779	Protein	denotes	PKD3
T4889	4889-4893	Protein	denotes	PKD1	true
T4890	4894-4895	Protein	denotes	3
T4891	5047-5054	Positive_regulation	denotes	induced	true
T4892	5055-5065	Positive_regulation	denotes	activation
T4893	5073-5076	Protein	denotes	Akt	true
T4894	5078-5082	Protein	denotes	mTOR	true
T4895	5110-5130	Protein	denotes	S6 ribosomal protein	true
T4896	5131-5146	Phosphorylation	denotes	phosphorylation	true
T4897	5203-5207	Protein	denotes	PKD1
T4898	5208-5209	Protein	denotes	3
T4899	5210-5214	Negative_regulation	denotes	null
T4900	5413-5417	Protein	denotes	PKD1
T4901	5418-5419	Protein	denotes	3
T4902	5420-5424	Negative_regulation	denotes	null
T4903	5523-5533	Regulation	denotes	regulation
T4904	5541-5545	Protein	denotes	Erk1
T4905	5546-5550	Protein	denotes	RSK1
T4906	5574-5581	Negative_regulation	denotes	reduced
T4907	5585-5589	Protein	denotes	PKD1
T4908	5590-5591	Protein	denotes	3
T4909	5882-5889	Positive_regulation	denotes	induced
T4910	5894-5909	Phosphorylation	denotes	phosphorylation
T4911	5919-5926	Negative_regulation	denotes	reduced
T4912	5930-5934	Protein	denotes	PKD1
T4913	5935-5936	Protein	denotes	3
T4914	5945-5949	Protein	denotes	PKD3
T4915	6029-6033	Protein	denotes	PKD1
T4916	6034-6035	Protein	denotes	3
T4917	6044-6048	Protein	denotes	PKD1
T4918	6049-6050	Protein	denotes	3
T4919	6059-6063	Protein	denotes	PKD3
T4920	6253-6257	Protein	denotes	PKD1
T4921	6258-6259	Protein	denotes	3
T4922	6566-6570	Protein	denotes	PKD1
T4923	6571-6572	Protein	denotes	3
T4924	6671-6675	Protein	denotes	PKD1
T4925	6676-6677	Protein	denotes	3
T4926	6847-6851	Negative_regulation	denotes	loss
T4927	6855-6859	Protein	denotes	PKD1
T4928	6860-6861	Protein	denotes	3
T4929	7096-7104	Protein	denotes	MAPKAPK2
T4930	7720-7736	Protein	denotes	Bcr-Abl oncogene
T4931	7785-7794	Positive_regulation	denotes	activated
T4932	7795-7799	Protein	denotes	PKD1
T4933	7816-7820	Protein	denotes	HPK1
T4934	7884-7893	Regulation	denotes	regulated
T4935	7906-7910	Protein	denotes	PKCβ
T4936	8104-8108	Protein	denotes	PKD1
T4937	8109-8110	Protein	denotes	3
T4938	8273-8278	Protein	denotes	PKCβ−
T4939	8363-8382	Phosphorylation	denotes	autophosphorylation
T4940	8386-8390	Protein	denotes	PKD1
T4941	8420-8425	Protein	denotes	PKCβ−
R1820	T2154	T2153	themeOf	PKD1,lacked
R1821	T2155	T2153	themeOf	PKD3,lacked
R1822	T2157	T2156	themeOf	expression,induced
R1823	T2158	T2157	themeOf	PKD3,expression
R1825	T2161	T2159	themeOf	phosphorylation,regulation
R1790	T2103	T2104	themeOf	HSP27,phosphorylation
R1791	T2106	T2105	themeOf	PKD1,express
R1792	T2107	T2105	themeOf	PKD3,express
R1793	T2109	T2108	themeOf	expression,lack
R1794	T2110	T2109	themeOf	PKD1,expression
R1795	T2111	T2109	themeOf	PKD3,expression
R1796	T2115	T2114	themeOf	PKD3,expressed
R1797	T2116	T2117	themeOf	PKD3,expression
R1798	T2118	T2120	themeOf	PKD1,knockout
R1799	T2127	T2126	themeOf	phosphorylation,defective
R1800	T2132	T2133	themeOf	HSP27,phosphorylation
R1801	T2133	T2131	themeOf	phosphorylation,regulation
R1802	T2134	T2131	causeOf	knockout,regulation
R1803	T2135	T2131	causeOf	lacking,regulation
R1804	T2136	T2135	themeOf	PKD1,lacking
R1805	T2137	T2135	themeOf	PKD3,lacking
R1806	T2139	T2140	themeOf	HSP27,phosphorylation
R1807	T2140	T2138	themeOf	phosphorylation,increased
R1808	T2141	T2140	themeOf	S82,phosphorylation
R1809	T2141	T2139	partOf	S82,HSP27
R1810	T2143	T2144	themeOf	HSP27,phosphorylation
R1811	T2144	T2142	themeOf	phosphorylation,increase
R1812	T2145	T2147	themeOf	PKD1,knockout
R1813	T2146	T2147	themeOf	PKD3,knockout
R1814	T2148	T2152	themeOf	induced,abolished
R1815	T2149	T2148	themeOf	phosphorylation,induced
R1816	T2149	T2152	themeOf	phosphorylation,abolished
R1817	T2151	T2149	themeOf	S82,phosphorylation
R1818	T2151	T2150	partOf	S82,HSP27
R1819	T2153	T2152	causeOf	lacked,abolished
R1824	T2160	T2161	themeOf	HSP27,phosphorylation
R1826	T2165	T2164	themeOf	PKD3,deficient
R1827	T2165	T2162	themeOf	PKD3,expression
R1828	T2167	T2166	themeOf	induced,restore
R1829	T2168	T2169	themeOf	HSP27,phosphorylation
R1830	T2169	T2167	themeOf	phosphorylation,induced
R1831	T2170	T2172	causeOf	PKD3,regulate
R1832	T2171	T2172	causeOf	PKD1,regulate
R1833	T2173	T2174	themeOf	HSP27,phosphorylation
R1834	T2174	T2172	themeOf	phosphorylation,regulate
R3047	T3778	T3780	themeOf	PKD1,expression
R3048	T3779	T3780	themeOf	3,expression
R3049	T3780	T3777	themeOf	expression,loss
R3888	T4882	T4883	themeOf	expression,reduced
R3889	T4892	T4891	themeOf	activation,induced
R3890	T4893	T4892	themeOf	Akt,activation
R3891	T4894	T4892	themeOf	mTOR,activation
R3892	T4895	T4896	themeOf	S6 ribosomal protein,phosphorylation
R3893	T4896	T4892	themeOf	phosphorylation,activation
R3894	T4897	T4899	themeOf	PKD1,null
R3895	T4898	T4899	themeOf	3,null
R3896	T4900	T4902	themeOf	PKD1,null
R3897	T4901	T4902	themeOf	3,null
R3898	T4909	T4911	themeOf	induced,reduced
R3899	T4910	T4909	themeOf	phosphorylation,induced
R3900	T4910	T4911	themeOf	phosphorylation,reduced
R3901	T4927	T4926	themeOf	PKD1,loss
R3902	T4935	T4934	causeOf	PKCβ,regulated
R3903	T4940	T4939	themeOf	PKD1,autophosphorylation

PMC:1942070 / 4530-13151 JSONTXT

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PMC:1942070 / 4530-13151 JSON TXT