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2_test

Id Subject Object Predicate Lexical cue
17349631-10859332-30580518 310-311 10859332 denotes 3
17349631-12506120-30580518 310-311 12506120 denotes 3
17349631-12506120-30580519 624-625 12506120 denotes 6
17349631-9765302-30580519 624-625 9765302 denotes 6
17349631-11062248-30580519 624-625 11062248 denotes 6
17349631-11410586-30580519 624-625 11410586 denotes 6
17349631-15590638-30580520 769-770 15590638 denotes 7
17349631-10471840-30580521 846-848 10471840 denotes 12
17349631-10856238-30580521 846-848 10856238 denotes 12
17349631-11410587-30580521 846-848 11410587 denotes 12
17349631-12646243-30580521 846-848 12646243 denotes 12
17349631-12676944-30580521 846-848 12676944 denotes 12
17349631-11912133-30580522 956-958 11912133 denotes 16
17349631-11514571-30580522 956-958 11514571 denotes 16
17349631-16899224-30580522 956-958 16899224 denotes 16
17349631-12505989-30580523 988-990 12505989 denotes 18
17349631-14654790-30580523 988-990 14654790 denotes 18
17349631-14563314-30580524 1019-1021 14563314 denotes 19
17349631-16678913-30580525 1180-1182 16678913 denotes 20
17349631-12505989-30580526 1344-1346 12505989 denotes 23
17349631-15604256-30580526 1344-1346 15604256 denotes 23
17349631-15226414-30580526 1344-1346 15226414 denotes 23
17349631-15728188-30580527 1400-1402 15728188 denotes 24
17349631-16875491-30580528 1489-1491 16875491 denotes 25
17349631-16449666-30580529 1670-1672 16449666 denotes 28
17349631-15738054-30580529 1670-1672 15738054 denotes 28
17349631-15623513-30580529 1670-1672 15623513 denotes 28
17349631-15367659-30580529 1670-1672 15367659 denotes 28
17349631-16449666-30580530 1817-1818 16449666 denotes 1
17349631-16449666-30580531 2117-2118 16449666 denotes 1

MyTest

Id Subject Object Predicate Lexical cue
17349631-10859332-30580518 310-311 10859332 denotes 3
17349631-12506120-30580518 310-311 12506120 denotes 3
17349631-12506120-30580519 624-625 12506120 denotes 6
17349631-9765302-30580519 624-625 9765302 denotes 6
17349631-11062248-30580519 624-625 11062248 denotes 6
17349631-11410586-30580519 624-625 11410586 denotes 6
17349631-15590638-30580520 769-770 15590638 denotes 7
17349631-10471840-30580521 846-848 10471840 denotes 12
17349631-10856238-30580521 846-848 10856238 denotes 12
17349631-11410587-30580521 846-848 11410587 denotes 12
17349631-12646243-30580521 846-848 12646243 denotes 12
17349631-12676944-30580521 846-848 12676944 denotes 12
17349631-11912133-30580522 956-958 11912133 denotes 16
17349631-11514571-30580522 956-958 11514571 denotes 16
17349631-16899224-30580522 956-958 16899224 denotes 16
17349631-12505989-30580523 988-990 12505989 denotes 18
17349631-14654790-30580523 988-990 14654790 denotes 18
17349631-14563314-30580524 1019-1021 14563314 denotes 19
17349631-16678913-30580525 1180-1182 16678913 denotes 20
17349631-12505989-30580526 1344-1346 12505989 denotes 23
17349631-15604256-30580526 1344-1346 15604256 denotes 23
17349631-15226414-30580526 1344-1346 15226414 denotes 23
17349631-15728188-30580527 1400-1402 15728188 denotes 24
17349631-16875491-30580528 1489-1491 16875491 denotes 25
17349631-16449666-30580529 1670-1672 16449666 denotes 28
17349631-15738054-30580529 1670-1672 15738054 denotes 28
17349631-15623513-30580529 1670-1672 15623513 denotes 28
17349631-15367659-30580529 1670-1672 15367659 denotes 28
17349631-16449666-30580530 1817-1818 16449666 denotes 1
17349631-16449666-30580531 2117-2118 16449666 denotes 1

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T533 20-27 NN denotes protein
T534 28-34 NN denotes kinase
T535 35-36 NN denotes D
T536 37-38 -LRB- denotes (
T537 38-41 NN denotes PKD
T538 41-42 -RRB- denotes )
T539 43-59 NN denotes serine/threonine
T540 60-66 NN denotes kinase
T541 67-73 NN denotes family
T542 74-77 VB denotes has
T543 78-83 CD denotes three
T544 84-91 NN denotes members
T545 91-92 -COLON- denotes :
T546 93-97 NN denotes PKD1
T547 97-98 -COMMA- denotes ,
T548 99-103 NN denotes PKD2
T549 104-107 CC denotes and
T550 108-112 NN denotes PKD3
T551 114-118 JJ denotes Most
T552 119-123 NN denotes cell
T553 124-129 NN denotes types
T554 130-137 VB denotes express
T555 138-140 IN denotes at
T556 141-146 JJ denotes least
T557 147-150 CD denotes two
T558 151-154 NN denotes PKD
T559 155-163 NN denotes isoforms
T560 164-167 CC denotes but
T561 168-171 NN denotes PKD
T562 172-179 NN denotes enzymes
T563 180-183 VB denotes are
T564 184-194 RB denotes especially
T565 195-201 RB denotes highly
T566 202-211 VB denotes expressed
T567 212-214 IN denotes in
T568 215-229 JJ denotes haematopoietic
T569 230-235 NN denotes cells
T570 235-236 -COMMA- denotes ,
T571 237-242 WRB denotes where
T572 243-247 PRP denotes they
T573 248-251 VB denotes are
T574 252-261 VB denotes activated
T575 262-264 IN denotes in
T576 265-273 NN denotes response
T577 274-276 TO denotes to
T578 277-284 NN denotes antigen
T579 285-294 NN denotes receptors
T580 295-306 NN denotes stimulation
T581 307-308 -LRB- denotes [
T582 308-311 CD denotes 2,3
T583 311-312 -RRB- denotes ]
T584 314-315 DT denotes A
T585 316-325 VB denotes conserved
T586 326-336 NN denotes signalling
T587 337-344 NN denotes pathway
T588 345-352 VB denotes linking
T589 353-360 NN denotes antigen
T590 361-370 NN denotes receptors
T591 371-373 TO denotes to
T592 374-378 NN denotes PKDs
T593 379-387 VB denotes involves
T594 388-391 DT denotes the
T595 392-402 NN denotes activation
T596 403-405 IN denotes of
T597 406-410 NN denotes PLCγ
T598 411-414 CC denotes and
T599 415-418 DT denotes the
T600 419-429 JJ denotes subsequent
T601 430-440 NN denotes production
T602 441-443 IN denotes of
T603 444-458 NN denotes diacylglycerol
T604 459-460 -LRB- denotes (
T605 460-463 NN denotes DAG
T606 463-464 -RRB- denotes )
T607 465-470 WDT denotes which
T608 471-481 VB denotes stimulates
T609 482-491 JJ denotes classical
T610 492-498 CC denotes and/or
T611 499-504 JJ denotes novel
T612 505-512 NN denotes protein
T613 513-519 NN denotes kinase
T614 520-522 NN denotes Cs
T615 523-524 -LRB- denotes (
T616 524-527 NN denotes PKC
T617 527-528 -RRB- denotes )
T618 529-533 WDT denotes that
T619 534-547 VB denotes phosphorylate
T620 548-551 CD denotes two
T621 552-555 JJ denotes key
T622 556-566 JJ denotes regulatory
T623 567-573 NN denotes serine
T624 574-582 NN denotes residues
T625 583-585 IN denotes in
T626 586-589 DT denotes the
T627 590-600 NN denotes activation
T628 601-605 NN denotes loop
T629 606-608 IN denotes of
T630 609-612 NN denotes PKD
T631 613-620 NN denotes kinases
T632 621-622 -LRB- denotes [
T633 622-625 CD denotes 3–6
T634 625-626 -RRB- denotes ]
T635 628-631 DT denotes The
T636 632-642 JJ denotes N-terminal
T637 643-653 JJ denotes regulatory
T638 654-660 NN denotes region
T639 661-663 IN denotes of
T640 664-667 NN denotes PKD
T641 668-675 NN denotes enzymes
T642 676-684 VB denotes contains
T643 685-686 DT denotes a
T644 687-690 NN denotes DAG
T645 691-698 NN denotes binding
T646 699-705 NN denotes domain
T647 706-709 CC denotes and
T648 710-716 JJ denotes direct
T649 717-724 NN denotes binding
T650 725-727 IN denotes of
T651 728-731 NN denotes DAG
T652 732-736 RB denotes also
T653 737-748 VB denotes contributes
T654 749-751 TO denotes to
T655 752-756 NN denotes PKD1
T656 757-767 NN denotes activation
T657 768-769 -LRB- denotes [
T658 769-770 CD denotes 7
T659 770-771 -RRB- denotes ]
T660 772-774 RB denotes as
T661 775-779 RB denotes well
T662 780-782 IN denotes as
T663 783-793 VB denotes regulating
T664 794-797 DT denotes the
T665 798-805 JJ denotes spatial
T666 806-814 NN denotes location
T667 815-817 IN denotes of
T668 818-821 NN denotes PKD
T669 822-829 NN denotes enzymes
T670 830-836 IN denotes within
T671 837-842 NN denotes cells
T672 843-844 -LRB- denotes [
T673 844-848 CD denotes 8–12
T674 848-849 -RRB- denotes ]
T675 851-854 NN denotes PKD
T676 855-862 NN denotes enzymes
T677 863-867 VB denotes have
T678 868-872 VB denotes been
T679 873-881 VB denotes proposed
T680 882-884 TO denotes to
T681 885-893 VB denotes regulate
T682 894-902 JJ denotes numerous
T683 903-911 JJ denotes cellular
T684 912-921 NN denotes functions
T685 921-922 -COMMA- denotes ,
T686 923-932 VB denotes including
T687 933-937 NN denotes cell
T688 938-951 NN denotes proliferation
T689 952-953 -LRB- denotes [
T690 953-958 CD denotes 13–16
T691 958-959 -RRB- denotes ]
T692 959-960 -COMMA- denotes ,
T693 961-975 JJ denotes anti-apoptotic
T694 976-983 NN denotes signals
T695 984-985 -LRB- denotes [
T696 985-990 CD denotes 17,18
T697 990-991 -RRB- denotes ]
T698 992-995 CC denotes and
T699 996-1005 NN denotes thymocyte
T700 1006-1017 NN denotes development
T701 1018-1019 -LRB- denotes [
T702 1019-1021 CD denotes 19
T703 1021-1022 -RRB- denotes ]
T704 1024-1034 NN denotes Expression
T705 1035-1037 IN denotes of
T706 1038-1044 JJ denotes mutant
T707 1045-1058 RB denotes catalytically
T708 1059-1067 JJ denotes inactive
T709 1068-1071 CC denotes and
T710 1072-1086 RB denotes constitutively
T711 1087-1096 VB denotes activated
T712 1097-1101 NN denotes PKDs
T713 1102-1105 MD denotes can
T714 1106-1110 RB denotes also
T715 1111-1117 VB denotes modify
T716 1118-1123 NNP denotes Golgi
T717 1124-1132 NN denotes function
T718 1132-1133 -COMMA- denotes ,
T719 1134-1138 NN denotes cell
T720 1139-1147 NN denotes adhesion
T721 1148-1151 CC denotes and
T722 1152-1156 NN denotes cell
T723 1157-1165 NN denotes motility
T724 1166-1167 -LRB- denotes (
T725 1167-1175 VB denotes reviewed
T726 1176-1178 IN denotes in
T727 1179-1180 -LRB- denotes [
T728 1180-1182 CD denotes 20
T729 1182-1183 -RRB- denotes ]
T730 1183-1184 -RRB- denotes )
T731 1186-1188 IN denotes In
T732 1189-1199 JJ denotes particular
T733 1199-1200 -COMMA- denotes ,
T734 1201-1205 NN denotes PKDs
T735 1206-1210 VB denotes have
T736 1211-1215 VB denotes been
T737 1216-1222 RB denotes widely
T738 1223-1229 VB denotes linked
T739 1230-1232 TO denotes to
T740 1233-1236 DT denotes the
T741 1237-1247 NN denotes activation
T742 1248-1250 IN denotes of
T743 1251-1254 DT denotes the
T744 1255-1259 NN denotes NFκB
T745 1260-1273 NN denotes transcription
T746 1274-1280 NN denotes factor
T747 1281-1284 CC denotes and
T748 1285-1287 IN denotes in
T749 1288-1298 VB denotes regulating
T750 1299-1303 NN denotes cell
T751 1304-1312 NN denotes survival
T752 1313-1319 IN denotes during
T753 1320-1329 JJ denotes oxidative
T754 1330-1336 NN denotes stress
T755 1337-1338 -LRB- denotes [
T756 1338-1346 CD denotes 17,21–23
T757 1346-1347 -RRB- denotes ]
T758 1349-1356 DT denotes Another
T759 1357-1365 RB denotes recently
T760 1366-1374 VB denotes proposed
T761 1375-1379 NN denotes PKD1
T762 1380-1389 NN denotes substrate
T763 1390-1392 VB denotes is
T764 1393-1398 NN denotes HSP27
T765 1399-1400 -LRB- denotes [
T766 1400-1402 CD denotes 24
T767 1402-1403 -RRB- denotes ]
T768 1403-1404 -COMMA- denotes ,
T769 1405-1406 DT denotes a
T770 1407-1412 JJ denotes small
T771 1413-1417 NN denotes heat
T772 1418-1423 NN denotes shock
T773 1424-1431 NN denotes protein
T774 1432-1440 VB denotes involved
T775 1441-1443 IN denotes in
T776 1444-1454 VB denotes regulating
T777 1455-1459 NN denotes cell
T778 1460-1469 NN denotes migration
T779 1470-1473 CC denotes and
T780 1474-1478 NN denotes cell
T781 1479-1487 NN denotes survival
T782 1488-1489 -LRB- denotes [
T783 1489-1491 CD denotes 25
T784 1491-1492 -RRB- denotes ]
T785 1494-1496 DT denotes An
T786 1497-1506 JJ denotes essential
T787 1507-1511 NN denotes role
T788 1512-1515 IN denotes for
T789 1516-1519 NN denotes PKD
T790 1520-1527 NN denotes enzymes
T791 1528-1530 IN denotes in
T792 1531-1541 VB denotes regulating
T793 1542-1547 NN denotes class
T794 1548-1550 CD denotes II
T795 1551-1558 NN denotes histone
T796 1559-1571 NN denotes deacetylases
T797 1572-1573 -LRB- denotes (
T798 1573-1578 NN denotes HDACs
T799 1578-1579 -RRB- denotes )
T800 1579-1580 -COMMA- denotes ,
T801 1581-1588 NN denotes enzymes
T802 1589-1593 WDT denotes that
T803 1594-1601 VB denotes repress
T804 1602-1616 JJ denotes MEF2-dependent
T805 1617-1621 NN denotes gene
T806 1622-1635 NN denotes transcription
T807 1635-1636 -COMMA- denotes ,
T808 1637-1640 VB denotes has
T809 1641-1645 RB denotes also
T810 1646-1650 VB denotes been
T811 1651-1663 VB denotes demonstrated
T812 1664-1665 -LRB- denotes [
T813 1665-1672 CD denotes 1,26–28
T814 1672-1673 -RRB- denotes ]
T815 1675-1677 TO denotes To
T816 1678-1689 VB denotes investigate
T817 1690-1693 DT denotes the
T818 1694-1704 JJ denotes biological
T819 1705-1709 NN denotes role
T820 1710-1712 IN denotes of
T821 1713-1717 NN denotes PKDs
T822 1718-1720 PRP denotes we
T823 1721-1725 VB denotes have
T824 1726-1735 VB denotes generated
T825 1736-1740 NN denotes DT40
T826 1741-1742 NN denotes B
T827 1743-1747 NN denotes cell
T828 1748-1753 NN denotes lines
T829 1754-1758 WDT denotes that
T830 1759-1763 VB denotes lack
T831 1764-1774 NN denotes expression
T832 1775-1777 IN denotes of
T833 1778-1781 CD denotes one
T834 1782-1784 CC denotes or
T835 1785-1789 JJ denotes more
T836 1790-1797 NN denotes members
T837 1798-1800 IN denotes of
T838 1801-1804 DT denotes the
T839 1805-1808 NN denotes PKD
T840 1809-1815 NN denotes family
T841 1816-1817 -LRB- denotes [
T842 1817-1818 CD denotes 1
T843 1818-1819 -RRB- denotes ]
T844 1819-1820 -COMMA- denotes ,
T845 1821-1829 VB denotes allowing
T846 1830-1832 PRP denotes us
T847 1833-1835 TO denotes to
T848 1836-1847 VB denotes investigate
T849 1848-1851 DT denotes the
T850 1852-1860 NN denotes function
T851 1860-1861 -LRB- denotes (
T852 1861-1862 NN denotes s
T853 1862-1863 -RRB- denotes )
T854 1864-1866 IN denotes of
T855 1867-1870 NN denotes PKD
T856 1871-1879 NN denotes isoforms
T857 1880-1889 VB denotes following
T858 1890-1891 NN denotes B
T859 1892-1896 NN denotes cell
T860 1897-1904 NN denotes antigen
T861 1905-1913 NN denotes receptor
T862 1914-1915 -LRB- denotes (
T863 1915-1918 NN denotes BCR
T864 1918-1919 -RRB- denotes )
T865 1920-1931 NN denotes stimulation
T866 1931-1932 -COMMA- denotes ,
T867 1933-1935 RB denotes as
T868 1936-1940 RB denotes well
T869 1941-1951 VB denotes addressing
T870 1952-1955 DT denotes the
T871 1956-1961 NN denotes issue
T872 1962-1964 IN denotes of
T873 1965-1975 JJ denotes functional
T874 1976-1986 NN denotes redundancy
T875 1987-1994 IN denotes between
T876 1995-1998 DT denotes the
T877 1999-2008 JJ denotes different
T878 2009-2012 NN denotes PKD
T879 2013-2019 NN denotes family
T880 2020-2027 NN denotes members
T881 2029-2037 JJ denotes Previous
T882 2038-2045 NN denotes studies
T883 2046-2050 VB denotes have
T884 2051-2056 VB denotes shown
T885 2057-2061 IN denotes that
T886 2062-2066 NN denotes PKDs
T887 2067-2070 VB denotes are
T888 2071-2084 JJ denotes indispensable
T889 2085-2088 IN denotes for
T890 2089-2093 NN denotes HDAC
T891 2094-2104 NN denotes regulation
T892 2105-2107 IN denotes in
T893 2108-2109 NN denotes B
T894 2110-2115 NN denotes cells
T895 2116-2117 -LRB- denotes [
T896 2117-2118 CD denotes 1
T897 2118-2119 -RRB- denotes ]
T898 2121-2127 RB denotes Herein
T899 2128-2130 PRP denotes we
T900 2131-2135 VB denotes show
T901 2136-2140 IN denotes that
T902 2141-2145 NN denotes PKDs
T903 2146-2149 VB denotes are
T904 2150-2154 RB denotes also
T905 2155-2168 JJ denotes indispensable
T906 2169-2172 IN denotes for
T907 2173-2178 NN denotes HSP27
T908 2179-2194 NN denotes phosphorylation
T909 2195-2197 IN denotes in
T910 2198-2199 NN denotes B
T911 2200-2205 NN denotes cells
T912 2207-2214 RB denotes However
T913 2214-2215 -COMMA- denotes ,
T914 2216-2224 JJ denotes PKD-null
T915 2225-2229 NN denotes DT40
T916 2230-2231 NN denotes B
T917 2232-2237 NN denotes cells
T918 2238-2241 VB denotes are
T919 2242-2248 JJ denotes viable
T920 2249-2252 CC denotes and
T921 2253-2264 VB denotes proliferate
T922 2265-2273 RB denotes normally
T923 2275-2283 RB denotes Moreover
T924 2283-2284 -COMMA- denotes ,
T925 2285-2289 NN denotes loss
T926 2290-2292 IN denotes of
T927 2293-2296 DT denotes the
T928 2297-2303 JJ denotes entire
T929 2304-2312 JJ denotes cellular
T930 2313-2317 NN denotes pool
T931 2318-2320 IN denotes of
T932 2321-2324 NN denotes PKD
T933 2325-2329 VB denotes does
T934 2330-2333 RB denotes not
T935 2334-2344 RB denotes critically
T936 2345-2351 VB denotes affect
T937 2352-2361 JJ denotes oxidative
T938 2362-2368 NN denotes stress
T939 2369-2378 NN denotes responses
T940 2379-2381 IN denotes in
T941 2382-2383 NN denotes B
T942 2384-2389 NN denotes cells
T943 2390-2393 CC denotes nor
T944 2394-2396 VB denotes do
T945 2397-2400 NN denotes PKD
T946 2401-2408 NN denotes kinases
T947 2409-2413 VB denotes play
T948 2414-2416 DT denotes an
T949 2417-2426 JJ denotes essential
T950 2427-2431 NN denotes role
T951 2432-2434 IN denotes in
T952 2435-2445 VB denotes regulating
T953 2446-2450 NN denotes NFκB
T954 2451-2466 JJ denotes transcriptional
T955 2467-2475 NN denotes activity
T956 2477-2485 RB denotes Together
T957 2485-2486 -COMMA- denotes ,
T958 2487-2492 DT denotes these
T959 2493-2501 NN denotes findings
T960 2502-2508 VB denotes reveal
T961 2509-2513 IN denotes that
T962 2514-2516 IN denotes in
T963 2517-2518 NN denotes B
T964 2519-2530 NN denotes lymphocytes
T965 2530-2531 -COMMA- denotes ,
T966 2532-2535 NN denotes PKD
T967 2536-2543 NN denotes kinases
T968 2544-2547 VB denotes are
T969 2548-2551 RB denotes not
T970 2552-2560 JJ denotes critical
T971 2561-2571 NN denotes regulators
T972 2572-2574 IN denotes of
T973 2575-2579 JJ denotes many
T974 2580-2582 IN denotes of
T975 2583-2586 DT denotes the
T976 2587-2595 JJ denotes cellular
T977 2596-2605 NN denotes processes
T978 2606-2616 RB denotes previously
T979 2617-2625 VB denotes ascribed
T980 2626-2628 TO denotes to
T981 2629-2633 PRP denotes them
T982 2634-2636 IN denotes in
T983 2637-2642 JJ denotes other
T984 2643-2651 JJ denotes cellular
T985 2652-2659 NN denotes systems
R431 T535 T533 arg1Of D,protein
R432 T535 T534 arg1Of D,kinase
R433 T535 T536 arg1Of D,(
R434 T537 T536 arg2Of PKD,(
R435 T538 T536 arg3Of ),(
R436 T541 T535 arg1Of family,D
R437 T541 T539 arg1Of family,serine/threonine
R438 T541 T540 arg1Of family,kinase
R439 T541 T542 arg1Of family,has
R440 T544 T542 arg2Of members,has
R441 T544 T543 arg1Of members,three
R442 T544 T545 arg1Of members,:
R443 T546 T547 arg1Of PKD1,","
R444 T547 T549 arg1Of ",",and
R445 T548 T547 arg2Of PKD2,","
R446 T549 T545 arg2Of and,:
R447 T550 T549 arg2Of PKD3,and
R448 T553 T551 arg1Of types,Most
R449 T553 T552 arg1Of types,cell
R450 T553 T554 arg1Of types,express
R451 T554 T560 arg1Of express,but
R452 T557 T555 arg1Of two,at
R453 T557 T556 arg1Of two,least
R454 T559 T554 arg2Of isoforms,express
R455 T559 T557 arg1Of isoforms,two
R456 T559 T558 arg1Of isoforms,PKD
R457 T562 T561 arg1Of enzymes,PKD
R458 T562 T563 arg1Of enzymes,are
R459 T562 T566 arg2Of enzymes,expressed
R460 T565 T564 arg1Of highly,especially
R461 T566 T560 arg2Of expressed,but
R462 T566 T563 arg2Of expressed,are
R463 T566 T565 arg1Of expressed,highly
R464 T566 T567 arg1Of expressed,in
R465 T569 T567 arg2Of cells,in
R466 T569 T568 arg1Of cells,haematopoietic
R467 T569 T570 arg1Of cells,","
R468 T569 T571 arg1Of cells,where
R469 T572 T573 arg1Of they,are
R470 T572 T574 arg2Of they,activated
R471 T574 T571 arg2Of activated,where
R472 T574 T573 arg2Of activated,are
R473 T574 T575 arg1Of activated,in
R474 T574 T581 arg1Of activated,[
R475 T575 T577 arg1Of in,to
R476 T576 T575 arg2Of response,in
R477 T580 T575 arg3Of stimulation,in
R478 T580 T578 arg1Of stimulation,antigen
R479 T580 T579 arg1Of stimulation,receptors
R480 T582 T581 arg2Of "2,3",[
R481 T583 T581 arg3Of ],[
R482 T587 T584 arg1Of pathway,A
R483 T587 T585 arg2Of pathway,conserved
R484 T587 T586 arg1Of pathway,signalling
R485 T587 T588 arg1Of pathway,linking
R486 T587 T593 arg1Of pathway,involves
R487 T590 T588 arg2Of receptors,linking
R488 T590 T589 arg1Of receptors,antigen
R489 T590 T591 arg1Of receptors,to
R490 T592 T591 arg2Of PKDs,to
R491 T595 T594 arg1Of activation,the
R492 T595 T596 arg1Of activation,of
R493 T595 T598 arg1Of activation,and
R494 T597 T596 arg2Of PLCγ,of
R495 T598 T593 arg2Of and,involves
R496 T601 T598 arg2Of production,and
R497 T601 T599 arg1Of production,the
R498 T601 T600 arg1Of production,subsequent
R499 T601 T602 arg1Of production,of
R500 T601 T607 arg1Of production,which
R501 T601 T608 arg1Of production,stimulates
R502 T603 T602 arg2Of diacylglycerol,of
R503 T603 T604 arg1Of diacylglycerol,(
R504 T605 T604 arg2Of DAG,(
R505 T606 T604 arg3Of ),(
R506 T609 T610 arg1Of classical,and/or
R507 T611 T610 arg2Of novel,and/or
R508 T614 T608 arg2Of Cs,stimulates
R509 T614 T609 arg1Of Cs,classical
R510 T614 T611 arg1Of Cs,novel
R511 T614 T612 arg1Of Cs,protein
R512 T614 T613 arg1Of Cs,kinase
R513 T614 T615 arg1Of Cs,(
R514 T614 T618 arg1Of Cs,that
R515 T614 T619 arg1Of Cs,phosphorylate
R516 T616 T615 arg2Of PKC,(
R517 T617 T615 arg3Of ),(
R518 T619 T625 arg1Of phosphorylate,in
R519 T624 T619 arg2Of residues,phosphorylate
R520 T624 T620 arg1Of residues,two
R521 T624 T621 arg1Of residues,key
R522 T624 T622 arg1Of residues,regulatory
R523 T624 T623 arg1Of residues,serine
R524 T628 T625 arg2Of loop,in
R525 T628 T626 arg1Of loop,the
R526 T628 T627 arg1Of loop,activation
R527 T628 T629 arg1Of loop,of
R528 T628 T632 arg1Of loop,[
R529 T631 T629 arg2Of kinases,of
R530 T631 T630 arg1Of kinases,PKD
R531 T633 T632 arg2Of 3–6,[
R532 T634 T632 arg3Of ],[
R533 T638 T635 arg1Of region,The
R534 T638 T636 arg1Of region,N-terminal
R535 T638 T637 arg1Of region,regulatory
R536 T638 T639 arg1Of region,of
R537 T638 T642 arg1Of region,contains
R538 T641 T639 arg2Of enzymes,of
R539 T641 T640 arg1Of enzymes,PKD
R540 T642 T647 arg1Of contains,and
R541 T646 T642 arg2Of domain,contains
R542 T646 T643 arg1Of domain,a
R543 T646 T644 arg1Of domain,DAG
R544 T646 T645 arg1Of domain,binding
R545 T649 T648 arg1Of binding,direct
R546 T649 T650 arg1Of binding,of
R547 T649 T653 arg1Of binding,contributes
R548 T651 T650 arg2Of DAG,of
R549 T653 T647 arg2Of contributes,and
R550 T653 T652 arg1Of contributes,also
R551 T653 T654 arg1Of contributes,to
R552 T653 T657 arg1Of contributes,[
R553 T653 T661 arg1Of contributes,well
R554 T653 T662 arg1Of contributes,as
R555 T656 T654 arg2Of activation,to
R556 T656 T655 arg1Of activation,PKD1
R557 T658 T657 arg2Of 7,[
R558 T659 T657 arg3Of ],[
R559 T661 T660 arg1Of well,as
R560 T663 T662 arg2Of regulating,as
R561 T666 T663 arg2Of location,regulating
R562 T666 T664 arg1Of location,the
R563 T666 T665 arg1Of location,spatial
R564 T666 T667 arg1Of location,of
R565 T666 T670 arg1Of location,within
R566 T669 T667 arg2Of enzymes,of
R567 T669 T668 arg1Of enzymes,PKD
R568 T671 T670 arg2Of cells,within
R569 T671 T672 arg1Of cells,[
R570 T673 T672 arg2Of 8–12,[
R571 T674 T672 arg3Of ],[
R572 T676 T675 arg1Of enzymes,PKD
R573 T676 T677 arg1Of enzymes,have
R574 T676 T678 arg1Of enzymes,been
R575 T676 T679 arg2Of enzymes,proposed
R576 T676 T681 arg1Of enzymes,regulate
R577 T679 T677 arg2Of proposed,have
R578 T679 T678 arg2Of proposed,been
R579 T681 T679 arg3Of regulate,proposed
R580 T681 T680 arg1Of regulate,to
R581 T684 T681 arg2Of functions,regulate
R582 T684 T682 arg1Of functions,numerous
R583 T684 T683 arg1Of functions,cellular
R584 T684 T685 arg1Of functions,","
R585 T684 T686 arg1Of functions,including
R586 T688 T687 arg1Of proliferation,cell
R587 T688 T689 arg1Of proliferation,[
R588 T688 T692 arg1Of proliferation,","
R589 T690 T689 arg2Of 13–16,[
R590 T691 T689 arg3Of ],[
R591 T692 T698 arg1Of ",",and
R592 T694 T692 arg2Of signals,","
R593 T694 T693 arg1Of signals,anti-apoptotic
R594 T694 T695 arg1Of signals,[
R595 T696 T695 arg2Of "17,18",[
R596 T697 T695 arg3Of ],[
R597 T698 T686 arg2Of and,including
R598 T700 T698 arg2Of development,and
R599 T700 T699 arg1Of development,thymocyte
R600 T700 T701 arg1Of development,[
R601 T702 T701 arg2Of 19,[
R602 T703 T701 arg3Of ],[
R603 T704 T705 arg1Of Expression,of
R604 T704 T713 arg1Of Expression,can
R605 T704 T715 arg1Of Expression,modify
R606 T708 T709 arg1Of inactive,and
R607 T710 T709 arg2Of constitutively,and
R608 T712 T705 arg2Of PKDs,of
R609 T712 T706 arg1Of PKDs,mutant
R610 T712 T707 arg1Of PKDs,catalytically
R611 T712 T708 arg1Of PKDs,inactive
R612 T712 T710 arg1Of PKDs,constitutively
R613 T712 T711 arg2Of PKDs,activated
R614 T715 T713 arg2Of modify,can
R615 T715 T714 arg1Of modify,also
R616 T717 T716 arg1Of function,Golgi
R617 T717 T718 arg1Of function,","
R618 T718 T721 arg1Of ",",and
R619 T720 T718 arg2Of adhesion,","
R620 T720 T719 arg1Of adhesion,cell
R621 T721 T715 arg2Of and,modify
R622 T723 T721 arg2Of motility,and
R623 T723 T722 arg1Of motility,cell
R624 T723 T724 arg1Of motility,(
R625 T725 T724 arg2Of reviewed,(
R626 T725 T726 arg1Of reviewed,in
R627 T725 T727 arg1Of reviewed,[
R628 T728 T727 arg2Of 20,[
R629 T729 T727 arg3Of ],[
R630 T730 T724 arg3Of ),(
R631 T732 T731 arg2Of particular,In
R632 T734 T735 arg1Of PKDs,have
R633 T734 T736 arg1Of PKDs,been
R634 T734 T738 arg2Of PKDs,linked
R635 T734 T749 arg1Of PKDs,regulating
R636 T738 T731 arg1Of linked,In
R637 T738 T733 arg1Of linked,","
R638 T738 T735 arg2Of linked,have
R639 T738 T736 arg2Of linked,been
R640 T738 T737 arg1Of linked,widely
R641 T738 T739 arg1Of linked,to
R642 T738 T748 arg1Of linked,in
R643 T739 T747 arg1Of to,and
R644 T741 T739 arg2Of activation,to
R645 T741 T740 arg1Of activation,the
R646 T741 T742 arg1Of activation,of
R647 T746 T742 arg2Of factor,of
R648 T746 T743 arg1Of factor,the
R649 T746 T744 arg1Of factor,NFκB
R650 T746 T745 arg1Of factor,transcription
R651 T748 T747 arg2Of in,and
R652 T749 T748 arg2Of regulating,in
R653 T749 T752 arg1Of regulating,during
R654 T751 T749 arg2Of survival,regulating
R655 T751 T750 arg1Of survival,cell
R656 T754 T752 arg2Of stress,during
R657 T754 T753 arg1Of stress,oxidative
R658 T754 T755 arg1Of stress,[
R659 T756 T755 arg2Of "17,21–23",[
R660 T757 T755 arg3Of ],[
R661 T760 T759 arg1Of proposed,recently
R662 T762 T758 arg1Of substrate,Another
R663 T762 T760 arg1Of substrate,proposed
R664 T762 T761 arg1Of substrate,PKD1
R665 T762 T763 arg1Of substrate,is
R666 T764 T763 arg2Of HSP27,is
R667 T764 T765 arg1Of HSP27,[
R668 T764 T768 arg1Of HSP27,","
R669 T766 T765 arg2Of 24,[
R670 T767 T765 arg3Of ],[
R671 T773 T768 arg2Of protein,","
R672 T773 T769 arg1Of protein,a
R673 T773 T770 arg1Of protein,small
R674 T773 T771 arg1Of protein,heat
R675 T773 T772 arg1Of protein,shock
R676 T773 T774 arg2Of protein,involved
R677 T774 T775 arg1Of involved,in
R678 T776 T775 arg2Of regulating,in
R679 T776 T782 arg1Of regulating,[
R680 T778 T777 arg1Of migration,cell
R681 T778 T779 arg1Of migration,and
R682 T779 T776 arg2Of and,regulating
R683 T781 T779 arg2Of survival,and
R684 T781 T780 arg1Of survival,cell
R685 T783 T782 arg2Of 25,[
R686 T784 T782 arg3Of ],[
R687 T787 T785 arg1Of role,An
R688 T787 T786 arg1Of role,essential
R689 T787 T788 arg1Of role,for
R690 T787 T808 arg1Of role,has
R691 T787 T810 arg1Of role,been
R692 T787 T811 arg2Of role,demonstrated
R693 T790 T788 arg2Of enzymes,for
R694 T790 T789 arg1Of enzymes,PKD
R695 T790 T791 arg1Of enzymes,in
R696 T792 T791 arg2Of regulating,in
R697 T796 T792 arg2Of deacetylases,regulating
R698 T796 T793 arg1Of deacetylases,class
R699 T796 T794 arg1Of deacetylases,II
R700 T796 T795 arg1Of deacetylases,histone
R701 T796 T797 arg1Of deacetylases,(
R702 T796 T800 arg1Of deacetylases,","
R703 T798 T797 arg2Of HDACs,(
R704 T799 T797 arg3Of ),(
R705 T801 T800 arg2Of enzymes,","
R706 T801 T802 arg1Of enzymes,that
R707 T801 T803 arg1Of enzymes,repress
R708 T806 T803 arg2Of transcription,repress
R709 T806 T804 arg1Of transcription,MEF2-dependent
R710 T806 T805 arg1Of transcription,gene
R711 T811 T807 arg1Of demonstrated,","
R712 T811 T808 arg2Of demonstrated,has
R713 T811 T809 arg1Of demonstrated,also
R714 T811 T810 arg2Of demonstrated,been
R715 T811 T812 arg1Of demonstrated,[
R716 T813 T812 arg2Of "1,26–28",[
R717 T814 T812 arg3Of ],[
R718 T816 T815 arg1Of investigate,To
R719 T819 T816 arg2Of role,investigate
R720 T819 T817 arg1Of role,the
R721 T819 T818 arg1Of role,biological
R722 T819 T820 arg1Of role,of
R723 T821 T820 arg2Of PKDs,of
R724 T822 T816 arg1Of we,investigate
R725 T822 T823 arg1Of we,have
R726 T822 T824 arg1Of we,generated
R727 T824 T815 modOf generated,To
R728 T824 T823 arg2Of generated,have
R729 T828 T824 arg2Of lines,generated
R730 T828 T825 arg1Of lines,DT40
R731 T828 T826 arg1Of lines,B
R732 T828 T827 arg1Of lines,cell
R733 T828 T829 arg1Of lines,that
R734 T828 T830 arg1Of lines,lack
R735 T830 T844 arg1Of lack,","
R736 T830 T845 modOf lack,allowing
R737 T830 T866 arg1Of lack,","
R738 T830 T869 modOf lack,addressing
R739 T831 T830 arg2Of expression,lack
R740 T831 T832 arg1Of expression,of
R741 T833 T834 arg1Of one,or
R742 T833 T835 arg1Of one,more
R743 T836 T832 arg2Of members,of
R744 T836 T833 arg1Of members,one
R745 T836 T837 arg1Of members,of
R746 T840 T837 arg2Of family,of
R747 T840 T838 arg1Of family,the
R748 T840 T839 arg1Of family,PKD
R749 T840 T841 arg1Of family,[
R750 T842 T841 arg2Of 1,[
R751 T843 T841 arg3Of ],[
R752 T846 T845 arg2Of us,allowing
R753 T846 T848 arg1Of us,investigate
R754 T848 T845 arg3Of investigate,allowing
R755 T848 T847 arg1Of investigate,to
R756 T850 T848 arg2Of function,investigate
R757 T850 T849 arg1Of function,the
R758 T850 T851 arg1Of function,(
R759 T850 T854 arg1Of function,of
R760 T850 T857 arg1Of function,following
R761 T852 T851 arg2Of s,(
R762 T853 T851 arg3Of ),(
R763 T856 T854 arg2Of isoforms,of
R764 T856 T855 arg1Of isoforms,PKD
R765 T863 T862 arg2Of BCR,(
R766 T864 T862 arg3Of ),(
R767 T865 T857 arg2Of stimulation,following
R768 T865 T858 arg1Of stimulation,B
R769 T865 T859 arg1Of stimulation,cell
R770 T865 T860 arg1Of stimulation,antigen
R771 T865 T861 arg1Of stimulation,receptor
R772 T865 T862 arg1Of stimulation,(
R773 T869 T867 arg1Of addressing,as
R774 T869 T868 arg1Of addressing,well
R775 T871 T869 arg2Of issue,addressing
R776 T871 T870 arg1Of issue,the
R777 T871 T872 arg1Of issue,of
R778 T874 T872 arg2Of redundancy,of
R779 T874 T873 arg1Of redundancy,functional
R780 T874 T875 arg1Of redundancy,between
R781 T880 T875 arg2Of members,between
R782 T880 T876 arg1Of members,the
R783 T880 T877 arg1Of members,different
R784 T880 T878 arg1Of members,PKD
R785 T880 T879 arg1Of members,family
R786 T882 T881 arg1Of studies,Previous
R787 T882 T883 arg1Of studies,have
R788 T882 T884 arg1Of studies,shown
R789 T884 T883 arg2Of shown,have
R790 T886 T887 arg1Of PKDs,are
R791 T886 T888 arg1Of PKDs,indispensable
R792 T887 T884 arg2Of are,shown
R793 T887 T885 arg1Of are,that
R794 T887 T895 arg1Of are,[
R795 T888 T887 arg2Of indispensable,are
R796 T888 T889 arg1Of indispensable,for
R797 T891 T889 arg2Of regulation,for
R798 T891 T890 arg1Of regulation,HDAC
R799 T891 T892 arg1Of regulation,in
R800 T894 T892 arg2Of cells,in
R801 T894 T893 arg1Of cells,B
R802 T896 T895 arg2Of 1,[
R803 T897 T895 arg3Of ],[
R804 T899 T900 arg1Of we,show
R805 T900 T898 arg1Of show,Herein
R806 T902 T903 arg1Of PKDs,are
R807 T902 T905 arg1Of PKDs,indispensable
R808 T903 T900 arg2Of are,show
R809 T903 T901 arg1Of are,that
R810 T903 T904 arg1Of are,also
R811 T905 T903 arg2Of indispensable,are
R812 T905 T906 arg1Of indispensable,for
R813 T908 T906 arg2Of phosphorylation,for
R814 T908 T907 arg1Of phosphorylation,HSP27
R815 T908 T909 arg1Of phosphorylation,in
R816 T911 T909 arg2Of cells,in
R817 T911 T910 arg1Of cells,B
R818 T917 T914 arg1Of cells,PKD-null
R819 T917 T915 arg1Of cells,DT40
R820 T917 T916 arg1Of cells,B
R821 T917 T918 arg1Of cells,are
R822 T917 T919 arg1Of cells,viable
R823 T917 T921 arg1Of cells,proliferate
R824 T918 T920 arg1Of are,and
R825 T919 T918 arg2Of viable,are
R826 T920 T912 arg1Of and,However
R827 T920 T913 arg1Of and,","
R828 T921 T920 arg2Of proliferate,and
R829 T921 T922 arg1Of proliferate,normally
R830 T925 T926 arg1Of loss,of
R831 T925 T933 arg1Of loss,does
R832 T925 T936 arg1Of loss,affect
R833 T925 T944 arg1Of loss,do
R834 T930 T926 arg2Of pool,of
R835 T930 T927 arg1Of pool,the
R836 T930 T928 arg1Of pool,entire
R837 T930 T929 arg1Of pool,cellular
R838 T930 T931 arg1Of pool,of
R839 T932 T931 arg2Of PKD,of
R840 T936 T933 arg2Of affect,does
R841 T936 T934 arg1Of affect,not
R842 T936 T935 arg1Of affect,critically
R843 T936 T943 arg1Of affect,nor
R844 T939 T936 arg2Of responses,affect
R845 T939 T937 arg1Of responses,oxidative
R846 T939 T938 arg1Of responses,stress
R847 T939 T940 arg1Of responses,in
R848 T942 T940 arg2Of cells,in
R849 T942 T941 arg1Of cells,B
R850 T943 T923 arg1Of nor,Moreover
R851 T943 T924 arg1Of nor,","
R852 T944 T943 arg2Of do,nor
R853 T945 T944 arg2Of PKD,do
R854 T946 T947 arg1Of kinases,play
R855 T946 T952 arg1Of kinases,regulating
R856 T947 T944 arg3Of play,do
R857 T947 T951 arg1Of play,in
R858 T950 T947 arg2Of role,play
R859 T950 T948 arg1Of role,an
R860 T950 T949 arg1Of role,essential
R861 T952 T951 arg2Of regulating,in
R862 T955 T952 arg2Of activity,regulating
R863 T955 T953 arg1Of activity,NFκB
R864 T955 T954 arg1Of activity,transcriptional
R865 T959 T958 arg1Of findings,these
R866 T959 T960 arg1Of findings,reveal
R867 T960 T956 arg1Of reveal,Together
R868 T960 T957 arg1Of reveal,","
R869 T964 T962 arg2Of lymphocytes,in
R870 T964 T963 arg1Of lymphocytes,B
R871 T967 T966 arg1Of kinases,PKD
R872 T967 T968 arg1Of kinases,are
R873 T968 T960 arg2Of are,reveal
R874 T968 T961 arg1Of are,that
R875 T968 T962 arg1Of are,in
R876 T968 T965 arg1Of are,","
R877 T968 T969 arg1Of are,not
R878 T971 T968 arg2Of regulators,are
R879 T971 T970 arg1Of regulators,critical
R880 T971 T972 arg1Of regulators,of
R881 T973 T972 arg2Of many,of
R882 T973 T974 arg1Of many,of
R883 T977 T974 arg2Of processes,of
R884 T977 T975 arg1Of processes,the
R885 T977 T976 arg1Of processes,cellular
R886 T977 T979 arg2Of processes,ascribed
R887 T979 T978 arg1Of ascribed,previously
R888 T979 T980 arg1Of ascribed,to
R889 T979 T982 arg1Of ascribed,in
R890 T981 T980 arg2Of them,to
R891 T985 T982 arg2Of systems,in
R892 T985 T983 arg1Of systems,other
R893 T985 T984 arg1Of systems,cellular

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T1009 20-27 NN denotes protein
T1010 28-34 NN denotes kinase
T1011 35-36 NNP denotes D
T1012 37-38 -LRB- denotes (
T1013 38-41 NNP denotes PKD
T1014 41-42 -RRB- denotes )
T1015 43-59 JJ denotes serine/threonine
T1016 60-66 NN denotes kinase
T1017 67-73 NN denotes family
T1018 74-77 VBZ denotes has
T1019 78-83 CD denotes three
T1020 84-91 NNS denotes members
T1021 91-92 : denotes :
T1022 93-97 NNP denotes PKD1
T1023 97-98 , denotes ,
T1024 99-103 NNP denotes PKD2
T1025 104-107 CC denotes and
T1026 108-112 NNP denotes PKD3
T1027 112-113 . denotes .
T1028 114-118 JJS denotes Most
T1029 119-123 NN denotes cell
T1030 124-129 NNS denotes types
T1031 130-137 VBP denotes express
T1032 138-140 IN denotes at
T1033 141-146 JJS denotes least
T1034 147-150 CD denotes two
T1035 151-154 NNP denotes PKD
T1036 155-163 NNS denotes isoforms
T1037 164-167 CC denotes but
T1038 168-171 NNP denotes PKD
T1039 172-179 NNS denotes enzymes
T1040 180-183 VBP denotes are
T1041 184-194 RB denotes especially
T1042 195-201 RB denotes highly
T1043 202-211 VBN denotes expressed
T1044 212-214 IN denotes in
T1045 215-229 JJ denotes haematopoietic
T1046 230-235 NNS denotes cells
T1047 235-236 , denotes ,
T1048 237-242 WRB denotes where
T1049 243-247 PRP denotes they
T1050 248-251 VBP denotes are
T1051 252-261 VBN denotes activated
T1052 262-264 IN denotes in
T1053 265-273 NN denotes response
T1054 274-276 TO denotes to
T1055 277-284 NN denotes antigen
T1056 285-294 NNS denotes receptors
T1057 295-306 NN denotes stimulation
T1058 307-308 NNP denotes [
T1059 308-311 CD denotes 2,3
T1060 311-312 NNP denotes ]
T1061 312-313 . denotes .
T1062 314-315 DT denotes A
T1063 316-325 JJ denotes conserved
T1064 326-336 JJ denotes signalling
T1065 337-344 NN denotes pathway
T1066 345-352 VBG denotes linking
T1067 353-360 NN denotes antigen
T1068 361-370 NNS denotes receptors
T1069 371-373 TO denotes to
T1070 374-378 NNS denotes PKDs
T1071 379-387 VBZ denotes involves
T1072 388-391 DT denotes the
T1073 392-402 NN denotes activation
T1074 403-405 IN denotes of
T1075 406-410 NNP denotes PLCγ
T1076 411-414 CC denotes and
T1077 415-418 DT denotes the
T1078 419-429 JJ denotes subsequent
T1079 430-440 NN denotes production
T1080 441-443 IN denotes of
T1081 444-458 NN denotes diacylglycerol
T1082 459-460 -LRB- denotes (
T1083 460-463 NNP denotes DAG
T1084 463-464 -RRB- denotes )
T1085 465-470 WDT denotes which
T1086 471-481 VBZ denotes stimulates
T1087 482-491 JJ denotes classical
T1088 492-498 CC denotes and/or
T1089 499-504 JJ denotes novel
T1090 505-512 NN denotes protein
T1091 513-519 NN denotes kinase
T1092 520-522 NNS denotes Cs
T1093 523-524 -LRB- denotes (
T1094 524-527 NNP denotes PKC
T1095 527-528 -RRB- denotes )
T1096 529-533 WDT denotes that
T1097 534-547 VBP denotes phosphorylate
T1098 548-551 CD denotes two
T1099 552-555 JJ denotes key
T1100 556-566 JJ denotes regulatory
T1101 567-573 NN denotes serine
T1102 574-582 NNS denotes residues
T1103 583-585 IN denotes in
T1104 586-589 DT denotes the
T1105 590-600 NN denotes activation
T1106 601-605 NN denotes loop
T1107 606-608 IN denotes of
T1108 609-612 NNP denotes PKD
T1109 613-620 VBZ denotes kinases
T1110 621-622 NNP denotes [
T1111 622-623 CD denotes 3
T1112 624-625 CD denotes 6
T1113 625-626 NNP denotes ]
T1114 626-627 . denotes .
T1115 628-631 DT denotes The
T1116 632-642 JJ denotes N-terminal
T1117 643-653 JJ denotes regulatory
T1118 654-660 NN denotes region
T1119 661-663 IN denotes of
T1120 664-667 NNP denotes PKD
T1121 668-675 VBZ denotes enzymes
T1122 676-684 VBZ denotes contains
T1123 685-686 DT denotes a
T1124 687-690 NNP denotes DAG
T1125 691-698 JJ denotes binding
T1126 699-705 NN denotes domain
T1127 706-709 CC denotes and
T1128 710-716 JJ denotes direct
T1129 717-724 JJ denotes binding
T1130 725-727 IN denotes of
T1131 728-731 NNP denotes DAG
T1132 732-736 RB denotes also
T1133 737-748 VBZ denotes contributes
T1134 749-751 TO denotes to
T1135 752-756 CD denotes PKD1
T1136 757-767 NN denotes activation
T1137 768-769 NN denotes [
T1138 769-770 CD denotes 7
T1139 770-771 NNP denotes ]
T1140 772-774 RB denotes as
T1141 775-779 RB denotes well
T1142 780-782 IN denotes as
T1143 783-793 VBG denotes regulating
T1144 794-797 DT denotes the
T1145 798-805 JJ denotes spatial
T1146 806-814 NN denotes location
T1147 815-817 IN denotes of
T1148 818-821 NNP denotes PKD
T1149 822-829 VBZ denotes enzymes
T1150 830-836 IN denotes within
T1151 837-842 NNS denotes cells
T1152 843-844 VBP denotes [
T1153 844-845 CD denotes 8
T1154 846-848 CD denotes 12
T1155 848-849 NN denotes ]
T1156 849-850 . denotes .
T1157 851-854 NNP denotes PKD
T1158 855-862 NNS denotes enzymes
T1159 863-867 VBP denotes have
T1160 868-872 VBN denotes been
T1161 873-881 VBN denotes proposed
T1162 882-884 TO denotes to
T1163 885-893 VB denotes regulate
T1164 894-902 JJ denotes numerous
T1165 903-911 JJ denotes cellular
T1166 912-921 NNS denotes functions
T1167 921-922 , denotes ,
T1168 923-932 VBG denotes including
T1169 933-937 NN denotes cell
T1170 938-951 NN denotes proliferation
T1171 952-953 NNP denotes [
T1172 953-955 CD denotes 13
T1173 956-958 CD denotes 16
T1174 958-959 NNP denotes ]
T1175 959-960 , denotes ,
T1176 961-975 JJ denotes anti-apoptotic
T1177 976-983 NNS denotes signals
T1178 984-985 NNP denotes [
T1179 985-990 CD denotes 17,18
T1180 990-991 NNP denotes ]
T1181 992-995 CC denotes and
T1182 996-1005 JJ denotes thymocyte
T1183 1006-1017 NN denotes development
T1184 1018-1019 NNP denotes [
T1185 1019-1021 CD denotes 19
T1186 1021-1022 NNP denotes ]
T1187 1022-1023 . denotes .
T1188 1024-1034 NN denotes Expression
T1189 1035-1037 IN denotes of
T1190 1038-1044 JJ denotes mutant
T1191 1045-1058 RB denotes catalytically
T1192 1059-1067 JJ denotes inactive
T1193 1068-1071 CC denotes and
T1194 1072-1086 RB denotes constitutively
T1195 1087-1096 VBN denotes activated
T1196 1097-1101 NNS denotes PKDs
T1197 1102-1105 MD denotes can
T1198 1106-1110 RB denotes also
T1199 1111-1117 VB denotes modify
T1200 1118-1123 NNP denotes Golgi
T1201 1124-1132 NN denotes function
T1202 1132-1133 , denotes ,
T1203 1134-1138 NN denotes cell
T1204 1139-1147 NN denotes adhesion
T1205 1148-1151 CC denotes and
T1206 1152-1156 NN denotes cell
T1207 1157-1165 NN denotes motility
T1208 1166-1167 -LRB- denotes (
T1209 1167-1175 VBN denotes reviewed
T1210 1176-1178 IN denotes in
T1211 1179-1180 NNP denotes [
T1212 1180-1182 CD denotes 20
T1213 1182-1183 NNP denotes ]
T1214 1183-1184 -RRB- denotes )
T1215 1184-1185 . denotes .
T1216 1186-1188 IN denotes In
T1217 1189-1199 JJ denotes particular
T1218 1199-1200 , denotes ,
T1219 1201-1205 NNS denotes PKDs
T1220 1206-1210 VBP denotes have
T1221 1211-1215 VBN denotes been
T1222 1216-1222 RB denotes widely
T1223 1223-1229 VBN denotes linked
T1224 1230-1232 TO denotes to
T1225 1233-1236 DT denotes the
T1226 1237-1247 NN denotes activation
T1227 1248-1250 IN denotes of
T1228 1251-1254 DT denotes the
T1229 1255-1259 NNP denotes NFκB
T1230 1260-1273 NN denotes transcription
T1231 1274-1280 NN denotes factor
T1232 1281-1284 CC denotes and
T1233 1285-1287 IN denotes in
T1234 1288-1298 VBG denotes regulating
T1235 1299-1303 NN denotes cell
T1236 1304-1312 NN denotes survival
T1237 1313-1319 IN denotes during
T1238 1320-1329 JJ denotes oxidative
T1239 1330-1336 NN denotes stress
T1240 1337-1338 NNP denotes [
T1241 1338-1343 CD denotes 17,21
T1242 1344-1346 CD denotes 23
T1243 1346-1347 NNP denotes ]
T1244 1347-1348 . denotes .
T1245 1349-1356 DT denotes Another
T1246 1357-1365 RB denotes recently
T1247 1366-1374 VBN denotes proposed
T1248 1375-1379 NNP denotes PKD1
T1249 1380-1389 NN denotes substrate
T1250 1390-1392 VBZ denotes is
T1251 1393-1398 NNP denotes HSP27
T1252 1399-1400 NNP denotes [
T1253 1400-1402 CD denotes 24
T1254 1402-1403 NNP denotes ]
T1255 1403-1404 , denotes ,
T1256 1405-1406 DT denotes a
T1257 1407-1412 JJ denotes small
T1258 1413-1417 NN denotes heat
T1259 1418-1423 NN denotes shock
T1260 1424-1431 NN denotes protein
T1261 1432-1440 VBN denotes involved
T1262 1441-1443 IN denotes in
T1263 1444-1454 VBG denotes regulating
T1264 1455-1459 NN denotes cell
T1265 1460-1469 NN denotes migration
T1266 1470-1473 CC denotes and
T1267 1474-1478 NN denotes cell
T1268 1479-1487 NN denotes survival
T1269 1488-1489 NNP denotes [
T1270 1489-1491 CD denotes 25
T1271 1491-1492 NNP denotes ]
T1272 1492-1493 . denotes .
T1273 1494-1496 DT denotes An
T1274 1497-1506 JJ denotes essential
T1275 1507-1511 NN denotes role
T1276 1512-1515 IN denotes for
T1277 1516-1519 NNP denotes PKD
T1278 1520-1527 VBZ denotes enzymes
T1279 1528-1530 IN denotes in
T1280 1531-1541 VBG denotes regulating
T1281 1542-1547 NN denotes class
T1282 1548-1550 NNP denotes II
T1283 1551-1558 NN denotes histone
T1284 1559-1571 NNS denotes deacetylases
T1285 1572-1573 -LRB- denotes (
T1286 1573-1578 NNS denotes HDACs
T1287 1578-1579 -RRB- denotes )
T1288 1579-1580 , denotes ,
T1289 1581-1588 VBZ denotes enzymes
T1290 1589-1593 IN denotes that
T1291 1594-1601 VBZ denotes repress
T1292 1602-1616 JJ denotes MEF2-dependent
T1293 1617-1621 NN denotes gene
T1294 1622-1635 NN denotes transcription
T1295 1635-1636 , denotes ,
T1296 1637-1640 VBZ denotes has
T1297 1641-1645 RB denotes also
T1298 1646-1650 VBN denotes been
T1299 1651-1663 VBN denotes demonstrated
T1300 1664-1665 NNP denotes [
T1301 1665-1669 CD denotes 1,26
T1302 1670-1672 CD denotes 28
T1303 1672-1673 NN denotes ]
T1304 1673-1674 . denotes .
T1305 1675-1677 TO denotes To
T1306 1678-1689 VB denotes investigate
T1307 1690-1693 DT denotes the
T1308 1694-1704 JJ denotes biological
T1309 1705-1709 NN denotes role
T1310 1710-1712 IN denotes of
T1311 1713-1717 NNS denotes PKDs
T1312 1718-1720 PRP denotes we
T1313 1721-1725 VBP denotes have
T1314 1726-1735 VBN denotes generated
T1315 1736-1740 NNP denotes DT40
T1316 1741-1742 NNP denotes B
T1317 1743-1747 NN denotes cell
T1318 1748-1753 NNS denotes lines
T1319 1754-1758 WDT denotes that
T1320 1759-1763 VBP denotes lack
T1321 1764-1774 NN denotes expression
T1322 1775-1777 IN denotes of
T1323 1778-1781 CD denotes one
T1324 1782-1784 CC denotes or
T1325 1785-1789 JJR denotes more
T1326 1790-1797 NNS denotes members
T1327 1798-1800 IN denotes of
T1328 1801-1804 DT denotes the
T1329 1805-1808 NNP denotes PKD
T1330 1809-1815 NN denotes family
T1331 1816-1817 NNP denotes [
T1332 1817-1818 CD denotes 1
T1333 1818-1819 NNP denotes ]
T1334 1819-1820 , denotes ,
T1335 1821-1829 VBG denotes allowing
T1336 1830-1832 PRP denotes us
T1337 1833-1835 TO denotes to
T1338 1836-1847 VB denotes investigate
T1339 1848-1851 DT denotes the
T1340 1852-1860 NN denotes function
T1341 1860-1861 -LRB- denotes (
T1342 1861-1862 PRP denotes s
T1343 1862-1863 -RRB- denotes )
T1344 1864-1866 IN denotes of
T1345 1867-1870 NNP denotes PKD
T1346 1871-1879 VBZ denotes isoforms
T1347 1880-1889 VBG denotes following
T1348 1890-1891 NNP denotes B
T1349 1892-1896 NN denotes cell
T1350 1897-1904 NN denotes antigen
T1351 1905-1913 NN denotes receptor
T1352 1914-1915 -LRB- denotes (
T1353 1915-1918 NNP denotes BCR
T1354 1918-1919 -RRB- denotes )
T1355 1920-1931 NN denotes stimulation
T1356 1931-1932 , denotes ,
T1357 1933-1935 RB denotes as
T1358 1936-1940 RB denotes well
T1359 1941-1951 VBG denotes addressing
T1360 1952-1955 DT denotes the
T1361 1956-1961 NN denotes issue
T1362 1962-1964 IN denotes of
T1363 1965-1975 JJ denotes functional
T1364 1976-1986 NN denotes redundancy
T1365 1987-1994 IN denotes between
T1366 1995-1998 DT denotes the
T1367 1999-2008 JJ denotes different
T1368 2009-2012 NNP denotes PKD
T1369 2013-2019 NN denotes family
T1370 2020-2027 NNS denotes members
T1371 2027-2028 . denotes .
T1372 2029-2037 JJ denotes Previous
T1373 2038-2045 NNS denotes studies
T1374 2046-2050 VBP denotes have
T1375 2051-2056 VBN denotes shown
T1376 2057-2061 IN denotes that
T1377 2062-2066 NNS denotes PKDs
T1378 2067-2070 VBP denotes are
T1379 2071-2084 JJ denotes indispensable
T1380 2085-2088 IN denotes for
T1381 2089-2093 NNP denotes HDAC
T1382 2094-2104 NN denotes regulation
T1383 2105-2107 IN denotes in
T1384 2108-2109 NNP denotes B
T1385 2110-2115 NNS denotes cells
T1386 2116-2117 NNP denotes [
T1387 2117-2118 CD denotes 1
T1388 2118-2119 NNP denotes ]
T1389 2119-2120 . denotes .
T1390 2121-2127 NNP denotes Herein
T1391 2128-2130 PRP denotes we
T1392 2131-2135 VBP denotes show
T1393 2136-2140 IN denotes that
T1394 2141-2145 NNS denotes PKDs
T1395 2146-2149 VBP denotes are
T1396 2150-2154 RB denotes also
T1397 2155-2168 JJ denotes indispensable
T1398 2169-2172 IN denotes for
T1399 2173-2178 NNP denotes HSP27
T1400 2179-2194 NN denotes phosphorylation
T1401 2195-2197 IN denotes in
T1402 2198-2199 NNP denotes B
T1403 2200-2205 NNS denotes cells
T1404 2205-2206 . denotes .
T1405 2207-2214 RB denotes However
T1406 2214-2215 , denotes ,
T1407 2216-2224 NNP denotes PKD-null
T1408 2225-2229 NNP denotes DT40
T1409 2230-2231 NNP denotes B
T1410 2232-2237 NNS denotes cells
T1411 2238-2241 VBP denotes are
T1412 2242-2248 JJ denotes viable
T1413 2249-2252 CC denotes and
T1414 2253-2264 VB denotes proliferate
T1415 2265-2273 RB denotes normally
T1416 2273-2274 . denotes .
T1417 2275-2283 RB denotes Moreover
T1418 2283-2284 , denotes ,
T1419 2285-2289 NN denotes loss
T1420 2290-2292 IN denotes of
T1421 2293-2296 DT denotes the
T1422 2297-2303 JJ denotes entire
T1423 2304-2312 JJ denotes cellular
T1424 2313-2317 NN denotes pool
T1425 2318-2320 IN denotes of
T1426 2321-2324 NNP denotes PKD
T1427 2325-2329 VBZ denotes does
T1428 2330-2333 RB denotes not
T1429 2334-2344 RB denotes critically
T1430 2345-2351 VB denotes affect
T1431 2352-2361 JJ denotes oxidative
T1432 2362-2368 NN denotes stress
T1433 2369-2378 NNS denotes responses
T1434 2379-2381 IN denotes in
T1435 2382-2383 NNP denotes B
T1436 2384-2389 NNS denotes cells
T1437 2390-2393 CC denotes nor
T1438 2394-2396 VBP denotes do
T1439 2397-2400 NNP denotes PKD
T1440 2401-2408 VBZ denotes kinases
T1441 2409-2413 VB denotes play
T1442 2414-2416 DT denotes an
T1443 2417-2426 JJ denotes essential
T1444 2427-2431 NN denotes role
T1445 2432-2434 IN denotes in
T1446 2435-2445 VBG denotes regulating
T1447 2446-2450 NNP denotes NFκB
T1448 2451-2466 JJ denotes transcriptional
T1449 2467-2475 NN denotes activity
T1450 2475-2476 . denotes .
T1451 2477-2485 RB denotes Together
T1452 2485-2486 , denotes ,
T1453 2487-2492 DT denotes these
T1454 2493-2501 NNS denotes findings
T1455 2502-2508 VBP denotes reveal
T1456 2509-2513 IN denotes that
T1457 2514-2516 IN denotes in
T1458 2517-2518 NNP denotes B
T1459 2519-2530 NNS denotes lymphocytes
T1460 2530-2531 , denotes ,
T1461 2532-2535 NNP denotes PKD
T1462 2536-2543 NNS denotes kinases
T1463 2544-2547 VBP denotes are
T1464 2548-2551 RB denotes not
T1465 2552-2560 JJ denotes critical
T1466 2561-2571 NNS denotes regulators
T1467 2572-2574 IN denotes of
T1468 2575-2579 JJ denotes many
T1469 2580-2582 IN denotes of
T1470 2583-2586 DT denotes the
T1471 2587-2595 JJ denotes cellular
T1472 2596-2605 NNS denotes processes
T1473 2606-2616 RB denotes previously
T1474 2617-2625 VBD denotes ascribed
T1475 2626-2628 TO denotes to
T1476 2629-2633 PRP denotes them
T1477 2634-2636 IN denotes in
T1478 2637-2642 JJ denotes other
T1479 2643-2651 JJ denotes cellular
T1480 2652-2659 NNS denotes systems
T1481 2659-2660 . denotes .
R895 T1009 T1011 nmod protein,D
R896 T1010 T1011 compound kinase,D
R897 T1011 T1011 ROOT D,D
R898 T1012 T1011 punct (,D
R899 T1013 T1011 appos PKD,D
R900 T1014 T1011 punct ),D
R901 T1015 T1017 amod serine/threonine,family
R902 T1016 T1017 compound kinase,family
R903 T1017 T1018 nsubj family,has
R904 T1018 T1018 ROOT has,has
R905 T1019 T1020 nummod three,members
R906 T1020 T1018 dobj members,has
R907 T1021 T1018 punct :,has
R908 T1022 T1022 ROOT PKD1,PKD1
R909 T1023 T1022 punct ",",PKD1
R910 T1024 T1022 conj PKD2,PKD1
R911 T1025 T1024 cc and,PKD2
R912 T1026 T1024 conj PKD3,PKD2
R913 T1027 T1018 punct .,has
R914 T1028 T1030 amod Most,types
R915 T1029 T1030 compound cell,types
R916 T1030 T1031 nsubj types,express
R917 T1031 T1031 ROOT express,express
R918 T1032 T1033 advmod at,least
R919 T1033 T1034 advmod least,two
R920 T1034 T1036 nummod two,isoforms
R921 T1035 T1036 compound PKD,isoforms
R922 T1036 T1031 dobj isoforms,express
R923 T1037 T1031 cc but,express
R924 T1038 T1039 compound PKD,enzymes
R925 T1039 T1040 nsubj enzymes,are
R926 T1040 T1043 auxpass are,expressed
R927 T1041 T1042 advmod especially,highly
R928 T1042 T1043 advmod highly,expressed
R929 T1043 T1031 conj expressed,express
R930 T1044 T1043 prep in,expressed
R931 T1045 T1046 amod haematopoietic,cells
R932 T1046 T1044 pobj cells,in
R933 T1047 T1043 punct ",",expressed
R934 T1048 T1051 advmod where,activated
R935 T1049 T1051 nsubjpass they,activated
R936 T1050 T1051 auxpass are,activated
R937 T1051 T1043 advcl activated,expressed
R938 T1052 T1051 prep in,activated
R939 T1053 T1052 pobj response,in
R940 T1054 T1053 prep to,response
R941 T1055 T1056 compound antigen,receptors
R942 T1056 T1057 compound receptors,stimulation
R943 T1057 T1054 pobj stimulation,to
R944 T1058 T1060 compound [,]
R945 T1059 T1060 compound "2,3",]
R946 T1060 T1057 appos ],stimulation
R947 T1061 T1043 punct .,expressed
R948 T1062 T1065 det A,pathway
R949 T1063 T1065 amod conserved,pathway
R950 T1064 T1065 amod signalling,pathway
R951 T1065 T1071 nsubj pathway,involves
R952 T1066 T1065 acl linking,pathway
R953 T1067 T1068 compound antigen,receptors
R954 T1068 T1066 dobj receptors,linking
R955 T1069 T1066 prep to,linking
R956 T1070 T1069 pobj PKDs,to
R957 T1071 T1071 ROOT involves,involves
R958 T1072 T1073 det the,activation
R959 T1073 T1071 dobj activation,involves
R960 T1074 T1073 prep of,activation
R961 T1075 T1074 pobj PLCγ,of
R962 T1076 T1073 cc and,activation
R963 T1077 T1079 det the,production
R964 T1078 T1079 amod subsequent,production
R965 T1079 T1073 conj production,activation
R966 T1080 T1079 prep of,production
R967 T1081 T1080 pobj diacylglycerol,of
R968 T1082 T1083 punct (,DAG
R969 T1083 T1081 appos DAG,diacylglycerol
R970 T1084 T1081 punct ),diacylglycerol
R971 T1085 T1086 nsubj which,stimulates
R972 T1086 T1079 relcl stimulates,production
R973 T1087 T1090 amod classical,protein
R974 T1088 T1087 cc and/or,classical
R975 T1089 T1087 conj novel,classical
R976 T1090 T1092 compound protein,Cs
R977 T1091 T1092 compound kinase,Cs
R978 T1092 T1086 dobj Cs,stimulates
R979 T1093 T1092 punct (,Cs
R980 T1094 T1092 appos PKC,Cs
R981 T1095 T1092 punct ),Cs
R982 T1096 T1109 nsubj that,kinases
R983 T1097 T1096 aux phosphorylate,that
R984 T1098 T1102 nummod two,residues
R985 T1099 T1102 amod key,residues
R986 T1100 T1102 amod regulatory,residues
R987 T1101 T1102 compound serine,residues
R988 T1102 T1097 dobj residues,phosphorylate
R989 T1103 T1102 prep in,residues
R990 T1104 T1106 det the,loop
R991 T1105 T1106 compound activation,loop
R992 T1106 T1103 pobj loop,in
R993 T1107 T1106 prep of,loop
R994 T1108 T1107 pobj PKD,of
R995 T1109 T1079 relcl kinases,production
R996 T1110 T1109 dobj [,kinases
R997 T1111 T1110 nummod 3,[
R998 T1112 T1113 nummod 6,]
R999 T1113 T1079 appos ],production
R1000 T1114 T1071 punct .,involves
R1001 T1115 T1118 det The,region
R1002 T1116 T1118 amod N-terminal,region
R1003 T1117 T1118 amod regulatory,region
R1004 T1118 T1121 nsubj region,enzymes
R1005 T1119 T1118 prep of,region
R1006 T1120 T1119 pobj PKD,of
R1007 T1121 T1121 ROOT enzymes,enzymes
R1008 T1122 T1121 conj contains,enzymes
R1009 T1123 T1124 det a,DAG
R1010 T1124 T1126 nmod DAG,domain
R1011 T1125 T1126 amod binding,domain
R1012 T1126 T1122 dobj domain,contains
R1013 T1127 T1126 cc and,domain
R1014 T1128 T1129 amod direct,binding
R1015 T1129 T1126 conj binding,domain
R1016 T1130 T1129 prep of,binding
R1017 T1131 T1130 pobj DAG,of
R1018 T1132 T1133 advmod also,contributes
R1019 T1133 T1121 conj contributes,enzymes
R1020 T1134 T1133 prep to,contributes
R1021 T1135 T1139 nummod PKD1,]
R1022 T1136 T1137 compound activation,[
R1023 T1137 T1139 nmod [,]
R1024 T1138 T1137 nummod 7,[
R1025 T1139 T1134 pobj ],to
R1026 T1140 T1142 advmod as,as
R1027 T1141 T1142 advmod well,as
R1028 T1142 T1133 prep as,contributes
R1029 T1143 T1142 pcomp regulating,as
R1030 T1144 T1146 det the,location
R1031 T1145 T1146 amod spatial,location
R1032 T1146 T1143 dobj location,regulating
R1033 T1147 T1146 prep of,location
R1034 T1148 T1149 compound PKD,enzymes
R1035 T1149 T1147 pobj enzymes,of
R1036 T1150 T1143 prep within,regulating
R1037 T1151 T1150 pobj cells,within
R1038 T1152 T1153 nmod [,8
R1039 T1153 T1143 npadvmod 8,regulating
R1040 T1154 T1155 nummod 12,]
R1041 T1155 T1153 appos ],8
R1042 T1156 T1121 punct .,enzymes
R1043 T1157 T1158 compound PKD,enzymes
R1044 T1158 T1161 nsubjpass enzymes,proposed
R1045 T1159 T1161 aux have,proposed
R1062 T1176 T1177 amod anti-apoptotic,signals
R1063 T1177 T1171 appos signals,[
R1064 T1178 T1180 compound [,]
R1065 T1179 T1180 compound "17,18",]
R1066 T1180 T1177 dobj ],signals
R1067 T1181 T1180 cc and,]
R1068 T1182 T1183 amod thymocyte,development
R1069 T1183 T1186 nmod development,]
R1070 T1184 T1186 nmod [,]
R1071 T1185 T1186 nummod 19,]
R1072 T1186 T1180 conj ],]
R1073 T1187 T1177 punct .,signals
R1074 T1188 T1199 nsubj Expression,modify
R1075 T1189 T1188 prep of,Expression
R1076 T1190 T1192 amod mutant,inactive
R1077 T1191 T1192 advmod catalytically,inactive
R1078 T1192 T1196 amod inactive,PKDs
R1079 T1193 T1192 cc and,inactive
R1080 T1194 T1195 advmod constitutively,activated
R1081 T1195 T1192 conj activated,inactive
R1082 T1196 T1188 appos PKDs,Expression
R1083 T1197 T1199 aux can,modify
R1084 T1198 T1199 advmod also,modify
R1085 T1199 T1199 ROOT modify,modify
R1086 T1200 T1201 compound Golgi,function
R1087 T1201 T1199 dobj function,modify
R1088 T1202 T1201 punct ",",function
R1089 T1203 T1204 compound cell,adhesion
R1090 T1204 T1201 conj adhesion,function
R1091 T1205 T1204 cc and,adhesion
R1092 T1206 T1207 compound cell,motility
R1093 T1207 T1204 conj motility,adhesion
R1094 T1208 T1209 punct (,reviewed
R1095 T1209 T1199 advcl reviewed,modify
R1096 T1210 T1209 prep in,reviewed
R1097 T1211 T1210 pobj [,in
R1098 T1212 T1213 nummod 20,]
R1099 T1213 T1211 appos ],[
R1100 T1214 T1211 punct ),[
R1101 T1215 T1199 punct .,modify
R1102 T1216 T1223 prep In,linked
R1103 T1217 T1216 amod particular,In
R1104 T1218 T1223 punct ",",linked
R1105 T1219 T1223 nsubjpass PKDs,linked
R1106 T1220 T1223 aux have,linked
R1107 T1221 T1223 auxpass been,linked
R1108 T1222 T1223 advmod widely,linked
R1109 T1223 T1223 ROOT linked,linked
R1110 T1224 T1223 prep to,linked
R1111 T1225 T1226 det the,activation
R1112 T1226 T1224 pobj activation,to
R1113 T1227 T1226 prep of,activation
R1114 T1228 T1231 det the,factor
R1115 T1229 T1231 compound NFκB,factor
R1116 T1230 T1231 compound transcription,factor
R1117 T1231 T1227 pobj factor,of
R1118 T1232 T1224 cc and,to
R1119 T1233 T1223 prep in,linked
R1120 T1234 T1233 pcomp regulating,in
R1121 T1235 T1236 compound cell,survival
R1122 T1236 T1234 dobj survival,regulating
R1123 T1237 T1234 prep during,regulating
R1124 T1238 T1239 amod oxidative,stress
R1125 T1239 T1241 compound stress,"17,21"
R1126 T1240 T1241 compound [,"17,21"
R1127 T1241 T1237 pobj "17,21",during
R1175 T1289 T1289 ROOT enzymes,enzymes
R1176 T1290 T1291 mark that,repress
R1196 T1310 T1309 prep of,role
R1197 T1311 T1310 pobj PKDs,of
R1198 T1312 T1314 nsubj we,generated
R1199 T1313 T1314 aux have,generated
R1200 T1314 T1314 ROOT generated,generated
R1201 T1315 T1318 compound DT40,lines
R1202 T1316 T1318 compound B,lines
R1203 T1317 T1318 compound cell,lines
R1204 T1318 T1314 dobj lines,generated
R1205 T1319 T1320 nsubj that,lack
R1206 T1320 T1318 relcl lack,lines
R1207 T1321 T1320 dobj expression,lack
R1208 T1322 T1321 prep of,expression
R1209 T1323 T1326 nummod one,members
R1210 T1324 T1323 cc or,one
R1211 T1325 T1323 conj more,one
R1212 T1326 T1322 pobj members,of
R1213 T1327 T1326 prep of,members
R1214 T1328 T1330 det the,family
R1215 T1329 T1330 compound PKD,family
R1216 T1330 T1327 pobj family,of
R1217 T1331 T1333 nmod [,]
R1218 T1332 T1333 nummod 1,]
R1219 T1333 T1326 appos ],members
R1220 T1334 T1314 punct ",",generated
R1221 T1335 T1314 advcl allowing,generated
R1222 T1336 T1338 nsubj us,investigate
R1223 T1337 T1338 aux to,investigate
R1224 T1338 T1335 ccomp investigate,allowing
R1225 T1339 T1340 det the,function
R1226 T1340 T1338 dobj function,investigate
R1227 T1341 T1340 punct (,function
R1228 T1342 T1340 appos s,function
R1229 T1343 T1340 punct ),function
R1230 T1344 T1340 prep of,function
R1231 T1345 T1344 pobj PKD,of
R1232 T1346 T1344 pobj isoforms,of
R1233 T1347 T1346 acl following,isoforms
R1234 T1348 T1350 compound B,antigen
R1235 T1349 T1350 compound cell,antigen
R1236 T1350 T1351 compound antigen,receptor
R1237 T1351 T1347 dobj receptor,following
R1238 T1352 T1353 punct (,BCR
R1239 T1353 T1351 appos BCR,receptor
R1240 T1354 T1353 punct ),BCR
R1241 T1355 T1351 conj stimulation,receptor
R1242 T1356 T1347 punct ",",following
R1243 T1357 T1359 advmod as,addressing
R1244 T1358 T1359 advmod well,addressing
R1245 T1359 T1338 advcl addressing,investigate
R1246 T1360 T1361 det the,issue
R1247 T1361 T1359 dobj issue,addressing
R1248 T1362 T1361 prep of,issue
R1249 T1363 T1364 amod functional,redundancy
R1250 T1364 T1362 pobj redundancy,of
R1251 T1365 T1364 prep between,redundancy
R1252 T1366 T1370 det the,members
R1253 T1367 T1370 amod different,members
R1254 T1368 T1370 compound PKD,members
R1255 T1369 T1370 compound family,members
R1256 T1370 T1365 pobj members,between
R1257 T1371 T1314 punct .,generated
R1258 T1372 T1373 amod Previous,studies
R1259 T1373 T1375 nsubj studies,shown
R1261 T1374 T1375 aux have,shown
R1264 T1375 T1375 ROOT shown,shown
R1267 T1376 T1378 mark that,are
R1275 T1377 T1378 nsubj PKDs,are
R1279 T1378 T1375 ccomp are,shown
R1284 T1379 T1378 acomp indispensable,are
R1288 T1380 T1378 prep for,are
R1292 T1381 T1382 compound HDAC,regulation
R1296 T1382 T1380 pobj regulation,for
R1298 T1383 T1382 prep in,regulation
R1299 T1477 T1474 prep in,ascribed
R1300 T1478 T1480 amod other,systems
R1301 T1479 T1480 amod cellular,systems
R1302 T1480 T1477 pobj systems,in
R1303 T1384 T1385 compound B,cells
R1304 T1481 T1455 punct .,reveal
R1305 T1385 T1383 pobj cells,in
R1306 T1386 T1388 nmod [,]
R1307 T1387 T1388 nummod 1,]
R1308 T1388 T1382 appos ],regulation
R1309 T1389 T1375 punct .,shown
R1310 T1390 T1392 npadvmod Herein,show
R1311 T1391 T1392 nsubj we,show
R1312 T1392 T1392 ROOT show,show
R1313 T1393 T1395 mark that,are
R1314 T1394 T1395 nsubj PKDs,are
R1315 T1395 T1392 ccomp are,show
R1316 T1396 T1395 advmod also,are
R1317 T1397 T1395 acomp indispensable,are
R1318 T1398 T1395 prep for,are
R1319 T1399 T1400 compound HSP27,phosphorylation
R1320 T1400 T1398 pobj phosphorylation,for
R1321 T1401 T1400 prep in,phosphorylation
R1322 T1402 T1403 compound B,cells
R1323 T1403 T1401 pobj cells,in
R1324 T1404 T1392 punct .,show
R1325 T1405 T1411 advmod However,are
R1326 T1406 T1411 punct ",",are
R1327 T1407 T1409 compound PKD-null,B
R1328 T1408 T1409 compound DT40,B
R1329 T1409 T1410 compound B,cells
R1331 T1410 T1411 nsubj cells,are
R1335 T1411 T1411 ROOT are,are
R1336 T1412 T1411 acomp viable,are
R1338 T1413 T1411 cc and,are
R1340 T1414 T1411 conj proliferate,are
R1341 T1415 T1414 advmod normally,proliferate
R1342 T1416 T1411 punct .,are
R1343 T1417 T1430 advmod Moreover,affect
R1344 T1418 T1430 punct ",",affect
R1345 T1419 T1430 nsubj loss,affect
R1347 T1420 T1419 prep of,loss
R1351 T1421 T1424 det the,pool
R1352 T1422 T1424 amod entire,pool
R1355 T1423 T1424 amod cellular,pool
R1356 T1424 T1420 pobj pool,of
R1357 T1425 T1424 prep of,pool
R1358 T1426 T1425 pobj PKD,of
R1359 T1427 T1430 aux does,affect
R1360 T1428 T1430 neg not,affect
R1361 T1429 T1430 advmod critically,affect
R1362 T1430 T1430 ROOT affect,affect
R1365 T1431 T1433 amod oxidative,responses
R1367 T1432 T1433 compound stress,responses
R1369 T1433 T1430 dobj responses,affect
R1371 T1434 T1433 prep in,responses
R1373 T1435 T1436 compound B,cells
R1374 T1436 T1434 pobj cells,in
R1376 T1437 T1430 cc nor,affect
R1378 T1438 T1441 aux do,play
R1379 T1439 T1440 compound PKD,kinases
R1380 T1440 T1441 nsubj kinases,play
R1381 T1441 T1430 conj play,affect
R1382 T1442 T1444 det an,role
R1383 T1443 T1444 amod essential,role
R1384 T1444 T1441 dobj role,play
R1385 T1445 T1444 prep in,role
R1387 T1446 T1445 pcomp regulating,in
R1391 T1447 T1449 nmod NFκB,activity
R1050 T1164 T1166 amod numerous,functions
R1051 T1165 T1166 amod cellular,functions
R1052 T1166 T1163 dobj functions,regulate
R1053 T1167 T1166 punct ",",functions
R1054 T1168 T1166 prep including,functions
R1055 T1169 T1170 compound cell,proliferation
R1056 T1170 T1168 pobj proliferation,including
R1057 T1171 T1170 dobj [,proliferation
R1058 T1172 T1171 nummod 13,[
R1059 T1173 T1174 nummod 16,]
R1060 T1174 T1171 appos ],[
R1061 T1175 T1177 punct ",",signals
R1131 T1245 T1249 det Another,substrate
R1132 T1246 T1247 advmod recently,proposed
R1133 T1247 T1249 amod proposed,substrate
R1134 T1248 T1249 compound PKD1,substrate
R1135 T1249 T1250 nsubj substrate,is
R1136 T1250 T1250 ROOT is,is
R1137 T1251 T1252 compound HSP27,[
R1138 T1252 T1250 attr [,is
R1139 T1253 T1254 nummod 24,]
R1140 T1254 T1252 appos ],[
R1141 T1255 T1254 punct ",",]
R1142 T1256 T1260 det a,protein
R1143 T1257 T1260 amod small,protein
R1144 T1258 T1259 compound heat,shock
R1145 T1259 T1260 compound shock,protein
R1146 T1260 T1254 appos protein,]
R1147 T1261 T1260 amod involved,protein
R1148 T1262 T1261 prep in,involved
R1149 T1263 T1262 pcomp regulating,in
R1150 T1264 T1265 compound cell,migration
R1151 T1265 T1263 dobj migration,regulating
R1152 T1266 T1265 cc and,migration
R1153 T1267 T1268 compound cell,survival
R1154 T1268 T1265 conj survival,migration
R1155 T1269 T1271 nmod [,]
R1156 T1270 T1271 nummod 25,]
R1157 T1271 T1265 appos ],migration
R1158 T1272 T1250 punct .,is
R1159 T1273 T1275 det An,role
R1160 T1274 T1275 amod essential,role
R1161 T1275 T1289 nsubj role,enzymes
R1162 T1276 T1275 prep for,role
R1163 T1277 T1278 compound PKD,enzymes
R1164 T1278 T1276 pobj enzymes,for
R1165 T1279 T1278 prep in,enzymes
R1166 T1280 T1279 pcomp regulating,in
R1167 T1281 T1284 nmod class,deacetylases
R1168 T1282 T1281 nummod II,class
R1169 T1283 T1284 compound histone,deacetylases
R1170 T1284 T1280 dobj deacetylases,regulating
R1171 T1285 T1284 punct (,deacetylases
R1172 T1286 T1284 appos HDACs,deacetylases
R1173 T1287 T1284 punct ),deacetylases
R1174 T1288 T1278 punct ",",enzymes
R1177 T1291 T1289 ccomp repress,enzymes
R1178 T1292 T1294 amod MEF2-dependent,transcription
R1179 T1293 T1294 compound gene,transcription
R1180 T1294 T1291 dobj transcription,repress
R1181 T1295 T1299 punct ",",demonstrated
R1182 T1296 T1299 aux has,demonstrated
R1183 T1297 T1299 advmod also,demonstrated
R1184 T1298 T1299 auxpass been,demonstrated
R1185 T1299 T1289 conj demonstrated,enzymes
R1186 T1300 T1301 compound [,"1,26"
R1187 T1301 T1299 dobj "1,26",demonstrated
R1188 T1302 T1303 nummod 28,]
R1189 T1303 T1299 npadvmod ],demonstrated
R1190 T1304 T1299 punct .,demonstrated
R1191 T1305 T1306 aux To,investigate
R1192 T1306 T1314 advcl investigate,generated
R1193 T1307 T1309 det the,role
R1194 T1308 T1309 amod biological,role
R1195 T1309 T1306 dobj role,investigate
R1260 T1448 T1449 amod transcriptional,activity
R1262 T1449 T1446 dobj activity,regulating
R1263 T1450 T1441 punct .,play
R1265 T1451 T1455 advmod Together,reveal
R1266 T1452 T1455 punct ",",reveal
R1268 T1453 T1454 det these,findings
R1269 T1454 T1455 nsubj findings,reveal
R1270 T1455 T1455 ROOT reveal,reveal
R1271 T1456 T1463 mark that,are
R1272 T1457 T1463 prep in,are
R1273 T1458 T1459 compound B,lymphocytes
R1274 T1459 T1457 pobj lymphocytes,in
R1276 T1460 T1463 punct ",",are
R1277 T1461 T1462 compound PKD,kinases
R1278 T1462 T1463 nsubj kinases,are
R1280 T1463 T1455 ccomp are,reveal
R1281 T1464 T1463 neg not,are
R1282 T1465 T1466 amod critical,regulators
R1283 T1466 T1463 attr regulators,are
R1285 T1467 T1466 prep of,regulators
R1286 T1468 T1467 pobj many,of
R1287 T1469 T1468 prep of,many
R1289 T1470 T1472 det the,processes
R1290 T1471 T1472 amod cellular,processes
R1291 T1472 T1469 pobj processes,of
R1293 T1473 T1474 advmod previously,ascribed
R1294 T1474 T1463 conj ascribed,are
R1295 T1475 T1474 prep to,ascribed
R1297 T1476 T1475 pobj them,to
R1046 T1160 T1161 auxpass been,proposed
R1047 T1161 T1161 ROOT proposed,proposed
R1048 T1162 T1163 aux to,regulate
R1049 T1163 T1161 xcomp regulate,proposed
R1128 T1242 T1243 nummod 23,]
R1129 T1243 T1243 ROOT ],]
R1130 T1244 T1223 punct .,linked

GO-BP

Id Subject Object Predicate Lexical cue
T504 326-336 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T505 976-983 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T506 326-344 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathway
T507 524-527 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T508 903-911 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T509 2304-2312 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T510 2587-2595 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T511 2643-2651 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T512 933-951 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T513 1006-1017 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T514 1134-1147 http://purl.obolibrary.org/obo/GO_0007155 denotes cell adhesion
T515 1152-1165 http://purl.obolibrary.org/obo/GO_0048870 denotes cell motility
T516 1260-1273 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T517 1622-1635 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T518 2451-2466 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T519 1413-1431 http://purl.obolibrary.org/obo/GO_0006986 denotes heat shock protein
T520 1413-1431 http://purl.obolibrary.org/obo/GO_0034620 denotes heat shock protein
T521 1413-1431 http://purl.obolibrary.org/obo/GO_0042026 denotes heat shock protein
T522 1455-1469 http://purl.obolibrary.org/obo/GO_0016477 denotes cell migration
T523 2094-2104 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T524 2179-2194 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T525 2352-2378 http://purl.obolibrary.org/obo/GO_1902883 denotes oxidative stress responses
T526 2352-2378 http://purl.obolibrary.org/obo/GO_0006979 denotes oxidative stress responses
T527 2352-2378 http://purl.obolibrary.org/obo/GO_0097468 denotes oxidative stress responses
T528 2352-2378 http://purl.obolibrary.org/obo/GO_1902884 denotes oxidative stress responses
T529 2352-2378 http://purl.obolibrary.org/obo/GO_0034599 denotes oxidative stress responses
T530 2362-2378 http://purl.obolibrary.org/obo/GO_0006950 denotes stress responses
T531 2587-2605 http://purl.obolibrary.org/obo/GO_0009987 denotes cellular processes

GO-MF

Id Subject Object Predicate Lexical cue
T1483 524-527 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T1484 691-698 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1485 717-724 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T1499 1118-1123 http://purl.obolibrary.org/obo/GO_0005794 denotes Golgi
T1500 2587-2605 http://purl.obolibrary.org/obo/GO_0042995 denotes cellular processes
T1486 119-123 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1487 933-937 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1488 1134-1138 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1489 1152-1156 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1490 1299-1303 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1491 1455-1459 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1492 1474-1478 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1493 1743-1747 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1494 1892-1896 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1495 2110-2115 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1496 2200-2205 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1497 2232-2237 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1498 2384-2389 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T490 114-313 Sentence denotes Most cell types express at least two PKD isoforms but PKD enzymes are especially highly expressed in haematopoietic cells, where they are activated in response to antigen receptors stimulation [2,3].
T491 314-627 Sentence denotes A conserved signalling pathway linking antigen receptors to PKDs involves the activation of PLCγ and the subsequent production of diacylglycerol (DAG) which stimulates classical and/or novel protein kinase Cs (PKC) that phosphorylate two key regulatory serine residues in the activation loop of PKD kinases [3–6].
T492 628-850 Sentence denotes The N-terminal regulatory region of PKD enzymes contains a DAG binding domain and direct binding of DAG also contributes to PKD1 activation [7] as well as regulating the spatial location of PKD enzymes within cells [8–12].
T493 851-1023 Sentence denotes PKD enzymes have been proposed to regulate numerous cellular functions, including cell proliferation [13–16], anti-apoptotic signals [17,18] and thymocyte development [19].
T494 1024-1185 Sentence denotes Expression of mutant catalytically inactive and constitutively activated PKDs can also modify Golgi function, cell adhesion and cell motility (reviewed in [20]).
T495 1186-1348 Sentence denotes In particular, PKDs have been widely linked to the activation of the NFκB transcription factor and in regulating cell survival during oxidative stress [17,21–23].
T496 1349-1493 Sentence denotes Another recently proposed PKD1 substrate is HSP27 [24], a small heat shock protein involved in regulating cell migration and cell survival [25].
T497 1494-1674 Sentence denotes An essential role for PKD enzymes in regulating class II histone deacetylases (HDACs), enzymes that repress MEF2-dependent gene transcription, has also been demonstrated [1,26–28].
T498 1675-2028 Sentence denotes To investigate the biological role of PKDs we have generated DT40 B cell lines that lack expression of one or more members of the PKD family [1], allowing us to investigate the function(s) of PKD isoforms following B cell antigen receptor (BCR) stimulation, as well addressing the issue of functional redundancy between the different PKD family members.
T499 2029-2120 Sentence denotes Previous studies have shown that PKDs are indispensable for HDAC regulation in B cells [1].
T500 2121-2206 Sentence denotes Herein we show that PKDs are also indispensable for HSP27 phosphorylation in B cells.
T501 2207-2274 Sentence denotes However, PKD-null DT40 B cells are viable and proliferate normally.
T502 2275-2476 Sentence denotes Moreover, loss of the entire cellular pool of PKD does not critically affect oxidative stress responses in B cells nor do PKD kinases play an essential role in regulating NFκB transcriptional activity.
T503 2477-2660 Sentence denotes Together, these findings reveal that in B lymphocytes, PKD kinases are not critical regulators of many of the cellular processes previously ascribed to them in other cellular systems.
T11 0-15 Sentence denotes 1 Introduction
T12 16-113 Sentence denotes The protein kinase D (PKD) serine/threonine kinase family has three members: PKD1, PKD2 and PKD3.
T13 114-313 Sentence denotes Most cell types express at least two PKD isoforms but PKD enzymes are especially highly expressed in haematopoietic cells, where they are activated in response to antigen receptors stimulation [2,3].
T14 314-627 Sentence denotes A conserved signalling pathway linking antigen receptors to PKDs involves the activation of PLCγ and the subsequent production of diacylglycerol (DAG) which stimulates classical and/or novel protein kinase Cs (PKC) that phosphorylate two key regulatory serine residues in the activation loop of PKD kinases [3–6].
T15 628-850 Sentence denotes The N-terminal regulatory region of PKD enzymes contains a DAG binding domain and direct binding of DAG also contributes to PKD1 activation [7] as well as regulating the spatial location of PKD enzymes within cells [8–12].
T16 851-1023 Sentence denotes PKD enzymes have been proposed to regulate numerous cellular functions, including cell proliferation [13–16], anti-apoptotic signals [17,18] and thymocyte development [19].
T17 1024-1185 Sentence denotes Expression of mutant catalytically inactive and constitutively activated PKDs can also modify Golgi function, cell adhesion and cell motility (reviewed in [20]).
T18 1186-1348 Sentence denotes In particular, PKDs have been widely linked to the activation of the NFκB transcription factor and in regulating cell survival during oxidative stress [17,21–23].
T19 1349-1493 Sentence denotes Another recently proposed PKD1 substrate is HSP27 [24], a small heat shock protein involved in regulating cell migration and cell survival [25].
T20 1494-1674 Sentence denotes An essential role for PKD enzymes in regulating class II histone deacetylases (HDACs), enzymes that repress MEF2-dependent gene transcription, has also been demonstrated [1,26–28].
T21 1675-2028 Sentence denotes To investigate the biological role of PKDs we have generated DT40 B cell lines that lack expression of one or more members of the PKD family [1], allowing us to investigate the function(s) of PKD isoforms following B cell antigen receptor (BCR) stimulation, as well addressing the issue of functional redundancy between the different PKD family members.
T22 2029-2120 Sentence denotes Previous studies have shown that PKDs are indispensable for HDAC regulation in B cells [1].
T23 2121-2206 Sentence denotes Herein we show that PKDs are also indispensable for HSP27 phosphorylation in B cells.
T24 2207-2274 Sentence denotes However, PKD-null DT40 B cells are viable and proliferate normally.
T25 2275-2476 Sentence denotes Moreover, loss of the entire cellular pool of PKD does not critically affect oxidative stress responses in B cells nor do PKD kinases play an essential role in regulating NFκB transcriptional activity.
T26 2477-2660 Sentence denotes Together, these findings reveal that in B lymphocytes, PKD kinases are not critical regulators of many of the cellular processes previously ascribed to them in other cellular systems.

ICD10

Id Subject Object Predicate Lexical cue
T1482 1418-1423 http://purl.bioontology.org/ontology/ICD10/R57.9 denotes shock

events-check-again

Id Subject Object Predicate Lexical cue
T1575 93-97 Protein denotes PKD1
T1576 99-103 Protein denotes PKD2
T1577 108-112 Protein denotes PKD3
T1578 717-724 Binding denotes binding
T1579 737-748 Positive_regulation denotes contributes
T1580 752-756 Protein denotes PKD1
T1581 757-767 Positive_regulation denotes activation
T1582 1375-1379 Protein denotes PKD1
T1583 1393-1398 Protein denotes HSP27
T1584 1602-1606 Protein denotes MEF2
T1585 2155-2168 Positive_regulation denotes indispensable
T1586 2173-2178 Protein denotes HSP27
T1587 2179-2194 Phosphorylation denotes phosphorylation
R1400 T1578 T1579 causeOf binding,contributes
R1402 T1580 T1578 themeOf PKD1,binding
R1403 T1580 T1581 themeOf PKD1,activation
R1404 T1581 T1579 themeOf activation,contributes
R1405 T1586 T1587 themeOf HSP27,phosphorylation
R1406 T1587 T1585 themeOf phosphorylation,indispensable

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T1588 20-36 Protein denotes protein kinase D
T1589 38-41 Protein denotes PKD
T1590 43-73 Protein denotes serine/threonine kinase family
T1591 93-97 Protein denotes PKD1
T1592 99-103 Protein denotes PKD2
T1593 108-112 Protein denotes PKD3
T1594 151-154 Protein denotes PKD
T1595 168-171 Protein denotes PKD
T1596 130-137 Gene_expression denotes express
T1597 202-211 Gene_expression denotes expressed
T1598 374-378 Protein denotes PKDs
T1599 406-410 Protein denotes PLCγ
T1600 505-522 Protein denotes protein kinase Cs
T1601 524-527 Protein denotes PKC
T1602 609-620 Protein denotes PKD kinases
T1603 471-481 Positive_regulation denotes stimulates
T1604 471-481 Positive_regulation denotes stimulates
T1605 534-547 Phosphorylation denotes phosphorylate
T1606 534-547 Phosphorylation denotes phosphorylate
T1607 664-675 Protein denotes PKD enzymes
T1608 728-731 Protein denotes DAG
T1609 752-756 Protein denotes PKD1
T1610 818-829 Protein denotes PKD enzymes
T1611 717-724 Binding denotes binding
T1612 757-767 Positive_regulation denotes activation
T1613 806-814 Localization denotes location
T1614 737-748 Positive_regulation denotes contributes
T1615 783-793 Regulation denotes regulating
T1616 851-854 Protein denotes PKD
T1617 1097-1101 Protein denotes PKDs
T1618 1024-1034 Gene_expression denotes Expression
T1619 1087-1096 Positive_regulation denotes activated
T1620 1087-1096 Positive_regulation denotes activated
T1621 1201-1205 Protein denotes PKDs
T1622 1255-1280 Protein denotes NFκB transcription factor
T1623 1237-1247 Positive_regulation denotes activation
T1624 1375-1379 Protein denotes PKD1
T1625 1516-1527 Protein denotes PKD enzymes
T1626 1542-1571 Protein denotes class II histone deacetylases
T1627 1573-1578 Protein denotes HDACs
T1628 1602-1606 Protein denotes MEF2
T1629 1531-1541 Regulation denotes regulating
T1630 1531-1541 Regulation denotes regulating
T1631 1713-1717 Protein denotes PKDs
T1632 1805-1808 Protein denotes PKD
T1633 1867-1870 Protein denotes PKD
T1634 1890-1913 Protein denotes B cell antigen receptor
T1635 1915-1918 Protein denotes BCR
T1636 2009-2027 Protein denotes PKD family members
T1637 2062-2066 Protein denotes PKDs
T1638 2089-2093 Protein denotes HDAC
T1639 2094-2104 Regulation denotes regulation
T1640 2141-2145 Protein denotes PKDs
T1641 2173-2178 Protein denotes HSP27
T1642 2179-2194 Phosphorylation denotes phosphorylation
T1643 2155-2168 Positive_regulation denotes indispensable
T1644 2216-2219 Protein denotes PKD
T1645 2321-2324 Protein denotes PKD
T1646 2397-2408 Protein denotes PKD kinases
T1647 2446-2450 Protein denotes NFκB
T1648 2285-2289 Negative_regulation denotes loss
T1649 2532-2543 Protein denotes PKD kinases
R1413 T1609 T1612 themeOf PKD1,activation
R1414 T1610 T1613 themeOf PKD enzymes,location
R1415 T1611 T1614 causeOf binding,contributes
R1416 T1612 T1614 themeOf activation,contributes
R1417 T1613 T1615 themeOf location,regulating
R1418 T1617 T1618 themeOf PKDs,Expression
R1419 T1617 T1619 themeOf PKDs,activated
R1420 T1618 T1620 themeOf Expression,activated
R1421 T1622 T1623 themeOf NFκB transcription factor,activation
R1422 T1626 T1629 themeOf class II histone deacetylases,regulating
R1423 T1627 T1630 themeOf HDACs,regulating
R1424 T1638 T1639 themeOf HDAC,regulation
R1425 T1640 T1643 causeOf PKDs,indispensable
R1426 T1641 T1642 themeOf HSP27,phosphorylation
R1427 T1642 T1643 themeOf phosphorylation,indispensable
R1428 T1645 T1648 themeOf PKD,loss
R1401 T1594 T1596 themeOf PKD,express
R1407 T1595 T1597 themeOf PKD,expressed
R1408 T1600 T1603 themeOf protein kinase Cs,stimulates
R1409 T1600 T1605 themeOf protein kinase Cs,phosphorylate
R1410 T1601 T1604 themeOf PKC,stimulates
R1411 T1601 T1606 themeOf PKC,phosphorylate
R1412 T1608 T1611 themeOf DAG,binding

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue
T476 93-97 Protein denotes PKD1
T477 99-103 Protein denotes PKD2
T478 108-112 Protein denotes PKD3
T479 717-724 Binding denotes binding
T480 737-748 Positive_regulation denotes contributes
T481 752-756 Protein denotes PKD1
T482 757-767 Positive_regulation denotes activation
T483 1375-1379 Protein denotes PKD1
T484 1393-1398 Protein denotes HSP27
T485 1602-1606 Protein denotes MEF2
T486 2155-2168 Positive_regulation denotes indispensable
T487 2173-2178 Protein denotes HSP27
T488 2179-2194 Phosphorylation denotes phosphorylation
R424 T479 T480 causeOf binding,contributes
R425 T481 T479 themeOf PKD1,binding
R426 T481 T482 themeOf PKD1,activation
R427 T482 T480 themeOf activation,contributes
R428 T487 T488 themeOf HSP27,phosphorylation
R429 T488 T486 themeOf phosphorylation,indispensable

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T986 93-97 P98161 denotes PKD1
T987 108-112 Q99853 denotes PKD3
T988 752-756 P98161 denotes PKD1
T989 1375-1379 P98161 denotes PKD1
T990 1393-1398 P04792 denotes HSP27
T991 1915-1918 P11274 denotes BCR
T992 2173-2178 P04792 denotes HSP27

test2

Id Subject Object Predicate Lexical cue
T463 93-97 Protein denotes PKD1
T464 99-103 Protein denotes PKD2
T465 108-112 Protein denotes PKD3
T466 717-724 Binding denotes binding
T467 737-748 Positive_regulation denotes contributes
T468 752-756 Protein denotes PKD1
T469 757-767 Positive_regulation denotes activation
T470 1375-1379 Protein denotes PKD1
T471 1393-1398 Protein denotes HSP27
T472 1602-1606 Protein denotes MEF2
T473 2155-2168 Positive_regulation denotes indispensable
T474 2173-2178 Protein denotes HSP27
T475 2179-2194 Phosphorylation denotes phosphorylation
R419 T466 T467 causeOf binding,contributes
R420 T468 T469 themeOf PKD1,activation
R421 T469 T467 themeOf activation,contributes
R422 T474 T475 themeOf HSP27,phosphorylation
R423 T475 T473 themeOf phosphorylation,indispensable