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explore the function of TRIP13 in mammals, we generated mice with a gene trap-disrupted allele, Trip13RRB047 (Figure 1C; abbreviated as Trip13Gt). Heterozygotes were normal in all respects, but homozygotes were present at ∼2/3 the expected ratio from intercrosses between heterozygotes (91 Trip13 +/+, 183 Trip13Gt/+, and 61 Trip13Gt/Gt). Since \u003e90% of prewean mice that died were mutant homozygotes, this discrepancy is apparently due to a partially penetrant lethality. Most surviving Trip13Gt/Gt animals were grossly normal. However, homozygotes that were semi-congenic (N4) on the C57BL/6J strain were often markedly smaller and/or had kinked or shorter tails (Figure 2A and 2B)."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T1581","span":{"begin":661,"end":666},"obj":"UBERON:0002415"},{"id":"T1567","span":{"begin":27,"end":33},"obj":"PR:000016672"},{"id":"T1568","span":{"begin":37,"end":44},"obj":"NCBITaxon:40674"},{"id":"T1569","span":{"begin":59,"end":63},"obj":"NCBITaxon:10088"},{"id":"T1570","span":{"begin":71,"end":75},"obj":"SO:0000704"},{"id":"T1571","span":{"begin":91,"end":97},"obj":"SO:0001023"},{"id":"T1572","span":{"begin":99,"end":105},"obj":"PR:000016672"},{"id":"T1573","span":{"begin":139,"end":145},"obj":"PR:000016672"},{"id":"T1574","span":{"begin":293,"end":299},"obj":"PR:000016672"},{"id":"T1575","span":{"begin":309,"end":315},"obj":"PR:000016672"},{"id":"T1576","span":{"begin":328,"end":334},"obj":"PR:000016672"},{"id":"T1577","span":{"begin":364,"end":368},"obj":"NCBITaxon:10088"},{"id":"T1578","span":{"begin":374,"end":378},"obj":"GO:0016265"},{"id":"T1579","span":{"begin":490,"end":496},"obj":"PR:000016672"},{"id":"T1580","span":{"begin":502,"end":509},"obj":"NCBITaxon:33208"}],"text":"To explore the function of TRIP13 in mammals, we generated mice with a gene trap-disrupted allele, Trip13RRB047 (Figure 1C; abbreviated as Trip13Gt). Heterozygotes were normal in all respects, but homozygotes were present at ∼2/3 the expected ratio from intercrosses between heterozygotes (91 Trip13 +/+, 183 Trip13Gt/+, and 61 Trip13Gt/Gt). Since \u003e90% of prewean mice that died were mutant homozygotes, this discrepancy is apparently due to a partially penetrant lethality. Most surviving Trip13Gt/Gt animals were grossly normal. However, homozygotes that were semi-congenic (N4) on the C57BL/6J strain were often markedly smaller and/or had kinked or shorter tails (Figure 2A and 2B)."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T1634","span":{"begin":27,"end":33},"obj":"PR_EXT:000016672"},{"id":"T1635","span":{"begin":37,"end":44},"obj":"NCBITaxon:40674"},{"id":"T1636","span":{"begin":59,"end":63},"obj":"NCBITaxon:10088"},{"id":"T1637","span":{"begin":71,"end":80},"obj":"SO_EXT:gene_trap_or_trap_construct"},{"id":"T1638","span":{"begin":91,"end":97},"obj":"SO_EXT:0001023"},{"id":"T1639","span":{"begin":99,"end":105},"obj":"PR_EXT:000016672"},{"id":"T1640","span":{"begin":139,"end":145},"obj":"PR_EXT:000016672"},{"id":"T1641","span":{"begin":293,"end":299},"obj":"PR_EXT:000016672"},{"id":"T1642","span":{"begin":300,"end":301},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T1643","span":{"begin":302,"end":303},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T1644","span":{"begin":309,"end":315},"obj":"PR_EXT:000016672"},{"id":"T1645","span":{"begin":318,"end":319},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T1646","span":{"begin":328,"end":334},"obj":"PR_EXT:000016672"},{"id":"T1647","span":{"begin":364,"end":368},"obj":"NCBITaxon:10088"},{"id":"T1648","span":{"begin":374,"end":378},"obj":"GO:0016265"},{"id":"T1649","span":{"begin":384,"end":390},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T1650","span":{"begin":464,"end":473},"obj":"GO_EXT:fatality_or_lethality"},{"id":"T1651","span":{"begin":490,"end":496},"obj":"PR_EXT:000016672"},{"id":"T1652","span":{"begin":502,"end":509},"obj":"NCBITaxon:33208"},{"id":"T1653","span":{"begin":661,"end":666},"obj":"UBERON:0002415"}],"text":"To explore the function of TRIP13 in mammals, we generated mice with a gene trap-disrupted allele, Trip13RRB047 (Figure 1C; abbreviated as Trip13Gt). Heterozygotes were normal in all respects, but homozygotes were present at ∼2/3 the expected ratio from intercrosses between heterozygotes (91 Trip13 +/+, 183 Trip13Gt/+, and 61 Trip13Gt/Gt). Since \u003e90% of prewean mice that died were mutant homozygotes, this discrepancy is apparently due to a partially penetrant lethality. Most surviving Trip13Gt/Gt animals were grossly normal. However, homozygotes that were semi-congenic (N4) on the C57BL/6J strain were often markedly smaller and/or had kinked or shorter tails (Figure 2A and 2B)."}