Id |
Subject |
Object |
Predicate |
Lexical cue |
T6565 |
0-7 |
JJ |
denotes |
Genetic |
T6566 |
8-19 |
NNS |
denotes |
experiments |
T6567 |
37-45 |
VBD |
denotes |
provided |
T6568 |
20-22 |
IN |
denotes |
in |
T6569 |
23-25 |
NNP |
denotes |
S. |
T6570 |
26-36 |
NNP |
denotes |
cerevisiae |
T6571 |
46-54 |
NN |
denotes |
evidence |
T6572 |
55-59 |
IN |
denotes |
that |
T6573 |
85-93 |
VBZ |
denotes |
monitors |
T6574 |
60-63 |
DT |
denotes |
the |
T6575 |
74-84 |
NN |
denotes |
checkpoint |
T6576 |
64-73 |
NN |
denotes |
pachytene |
T6577 |
94-97 |
CC |
denotes |
and |
T6578 |
98-106 |
VBZ |
denotes |
responds |
T6579 |
107-109 |
IN |
denotes |
to |
T6580 |
110-125 |
JJ |
denotes |
recombinational |
T6581 |
130-136 |
NN |
denotes |
repair |
T6582 |
126-129 |
NN |
denotes |
DSB |
T6583 |
137-140 |
CC |
denotes |
and |
T6584 |
141-149 |
NN |
denotes |
synapsis |
T6585 |
150-163 |
RB |
denotes |
independently |
T6586 |
163-164 |
. |
denotes |
. |
T6587 |
164-300 |
sentence |
denotes |
Wu and Burgess concluded that the repair checkpoint is RAD17-SAE2 dependent, while the synapsis checkpoint is PCH2-ZIP1 dependent [12]. |
T6588 |
165-167 |
NNP |
denotes |
Wu |
T6589 |
180-189 |
VBD |
denotes |
concluded |
T6590 |
168-171 |
CC |
denotes |
and |
T6591 |
172-179 |
NNP |
denotes |
Burgess |
T6592 |
190-194 |
IN |
denotes |
that |
T6593 |
217-219 |
VBZ |
denotes |
is |
T6594 |
195-198 |
DT |
denotes |
the |
T6595 |
206-216 |
NN |
denotes |
checkpoint |
T6596 |
199-205 |
NN |
denotes |
repair |
T6597 |
220-225 |
NN |
denotes |
RAD17 |
T6598 |
226-230 |
NN |
denotes |
SAE2 |
T6599 |
225-226 |
HYPH |
denotes |
- |
T6600 |
231-240 |
JJ |
denotes |
dependent |
T6601 |
240-242 |
, |
denotes |
, |
T6602 |
242-247 |
IN |
denotes |
while |
T6603 |
272-274 |
VBZ |
denotes |
is |
T6604 |
248-251 |
DT |
denotes |
the |
T6605 |
261-271 |
NN |
denotes |
checkpoint |
T6606 |
252-260 |
NN |
denotes |
synapsis |
T6607 |
275-279 |
NN |
denotes |
PCH2 |
T6608 |
280-284 |
NN |
denotes |
ZIP1 |
T6609 |
279-280 |
HYPH |
denotes |
- |
T6610 |
285-294 |
JJ |
denotes |
dependent |
T6611 |
295-296 |
-LRB- |
denotes |
[ |
T6612 |
296-298 |
CD |
denotes |
12 |
T6613 |
298-299 |
-RRB- |
denotes |
] |
T6614 |
299-300 |
. |
denotes |
. |
T6615 |
300-520 |
sentence |
denotes |
Of these four genes, SAE2 and ZIP1 do not have clear mammalian orthologs (although SYCP1 may be a functional ortholog of ZIP1), and mutation of the mouse RAD17 ortholog, Rad1, presumably causes embryonic lethality [42]. |
T6616 |
301-303 |
IN |
denotes |
Of |
T6617 |
343-347 |
VB |
denotes |
have |
T6618 |
304-309 |
DT |
denotes |
these |
T6619 |
315-320 |
NNS |
denotes |
genes |
T6620 |
310-314 |
CD |
denotes |
four |
T6621 |
320-322 |
, |
denotes |
, |
T6622 |
322-326 |
NN |
denotes |
SAE2 |
T6623 |
327-330 |
CC |
denotes |
and |
T6624 |
331-335 |
NN |
denotes |
ZIP1 |
T6625 |
336-338 |
VBP |
denotes |
do |
T6626 |
339-342 |
RB |
denotes |
not |
T6627 |
348-353 |
JJ |
denotes |
clear |
T6628 |
364-373 |
NNS |
denotes |
orthologs |
T6629 |
354-363 |
JJ |
denotes |
mammalian |
T6630 |
374-375 |
-LRB- |
denotes |
( |
T6631 |
375-383 |
IN |
denotes |
although |
T6632 |
394-396 |
VB |
denotes |
be |
T6633 |
384-389 |
NN |
denotes |
SYCP1 |
T6634 |
390-393 |
MD |
denotes |
may |
T6635 |
397-398 |
DT |
denotes |
a |
T6636 |
410-418 |
NN |
denotes |
ortholog |
T6637 |
399-409 |
JJ |
denotes |
functional |
T6638 |
419-421 |
IN |
denotes |
of |
T6639 |
422-426 |
NN |
denotes |
ZIP1 |
T6640 |
426-427 |
-RRB- |
denotes |
) |
T6641 |
427-429 |
, |
denotes |
, |
T6642 |
429-432 |
CC |
denotes |
and |
T6643 |
433-441 |
NN |
denotes |
mutation |
T6644 |
488-494 |
VBZ |
denotes |
causes |
T6645 |
442-444 |
IN |
denotes |
of |
T6646 |
445-448 |
DT |
denotes |
the |
T6647 |
461-469 |
NN |
denotes |
ortholog |
T6648 |
449-454 |
NN |
denotes |
mouse |
T6649 |
455-460 |
NN |
denotes |
RAD17 |
T6650 |
469-471 |
, |
denotes |
, |
T6651 |
471-475 |
NN |
denotes |
Rad1 |
T6652 |
475-477 |
, |
denotes |
, |
T6653 |
477-487 |
RB |
denotes |
presumably |
T6654 |
495-504 |
JJ |
denotes |
embryonic |
T6655 |
505-514 |
NN |
denotes |
lethality |
T6656 |
515-516 |
-LRB- |
denotes |
[ |
T6657 |
516-518 |
CD |
denotes |
42 |
T6658 |
518-519 |
-RRB- |
denotes |
] |
T6659 |
519-520 |
. |
denotes |
. |
T6660 |
520-757 |
sentence |
denotes |
Thus, mutational analysis of mouse Pch2 (Trip13), which is also critical for the synapsis checkpoint in C. elegans [2], was the best remaining option to evaluate potential functional conservation in mammalian meiotic checkpoint control. |
T6661 |
521-525 |
RB |
denotes |
Thus |
T6662 |
641-644 |
VBD |
denotes |
was |
T6663 |
525-527 |
, |
denotes |
, |
T6664 |
527-537 |
JJ |
denotes |
mutational |
T6665 |
538-546 |
NN |
denotes |
analysis |
T6666 |
547-549 |
IN |
denotes |
of |
T6667 |
550-555 |
NN |
denotes |
mouse |
T6668 |
556-560 |
NN |
denotes |
Pch2 |
T6669 |
561-562 |
-LRB- |
denotes |
( |
T6670 |
562-568 |
NN |
denotes |
Trip13 |
T6671 |
568-569 |
-RRB- |
denotes |
) |
T6672 |
569-571 |
, |
denotes |
, |
T6673 |
571-576 |
WDT |
denotes |
which |
T6674 |
577-579 |
VBZ |
denotes |
is |
T6675 |
580-584 |
RB |
denotes |
also |
T6676 |
585-593 |
JJ |
denotes |
critical |
T6677 |
594-597 |
IN |
denotes |
for |
T6678 |
598-601 |
DT |
denotes |
the |
T6679 |
611-621 |
NN |
denotes |
checkpoint |
T6680 |
602-610 |
NN |
denotes |
synapsis |
T6681 |
622-624 |
IN |
denotes |
in |
T6682 |
625-627 |
NNP |
denotes |
C. |
T6683 |
628-635 |
NNP |
denotes |
elegans |
T6684 |
636-637 |
-LRB- |
denotes |
[ |
T6685 |
637-638 |
CD |
denotes |
2 |
T6686 |
638-639 |
-RRB- |
denotes |
] |
T6687 |
639-641 |
, |
denotes |
, |
T6688 |
645-648 |
DT |
denotes |
the |
T6689 |
664-670 |
NN |
denotes |
option |
T6690 |
649-653 |
JJS |
denotes |
best |
T6691 |
654-663 |
JJ |
denotes |
remaining |
T6692 |
671-673 |
TO |
denotes |
to |
T6693 |
674-682 |
VB |
denotes |
evaluate |
T6694 |
683-692 |
JJ |
denotes |
potential |
T6695 |
704-716 |
NN |
denotes |
conservation |
T6696 |
693-703 |
JJ |
denotes |
functional |
T6697 |
717-719 |
IN |
denotes |
in |
T6698 |
720-729 |
JJ |
denotes |
mammalian |
T6699 |
749-756 |
NN |
denotes |
control |
T6700 |
730-737 |
JJ |
denotes |
meiotic |
T6701 |
738-748 |
NN |
denotes |
checkpoint |
T6702 |
756-757 |
. |
denotes |
. |
R4005 |
T6565 |
T6566 |
amod |
Genetic,experiments |
R4006 |
T6566 |
T6567 |
nsubj |
experiments,provided |
R4007 |
T6568 |
T6566 |
prep |
in,experiments |
R4008 |
T6569 |
T6570 |
compound |
S.,cerevisiae |
R4009 |
T6570 |
T6568 |
pobj |
cerevisiae,in |
R4010 |
T6571 |
T6567 |
dobj |
evidence,provided |
R4011 |
T6572 |
T6573 |
mark |
that,monitors |
R4012 |
T6573 |
T6571 |
acl |
monitors,evidence |
R4013 |
T6574 |
T6575 |
det |
the,checkpoint |
R4014 |
T6575 |
T6573 |
nsubj |
checkpoint,monitors |
R4015 |
T6576 |
T6575 |
compound |
pachytene,checkpoint |
R4016 |
T6577 |
T6573 |
cc |
and,monitors |
R4017 |
T6578 |
T6573 |
conj |
responds,monitors |
R4018 |
T6579 |
T6578 |
prep |
to,responds |
R4019 |
T6580 |
T6581 |
amod |
recombinational,repair |
R4020 |
T6581 |
T6573 |
dobj |
repair,monitors |
R4021 |
T6582 |
T6581 |
compound |
DSB,repair |
R4022 |
T6583 |
T6581 |
cc |
and,repair |
R4023 |
T6584 |
T6581 |
conj |
synapsis,repair |
R4024 |
T6585 |
T6573 |
advmod |
independently,monitors |
R4025 |
T6586 |
T6567 |
punct |
.,provided |
R4026 |
T6588 |
T6589 |
nsubj |
Wu,concluded |
R4027 |
T6590 |
T6588 |
cc |
and,Wu |
R4028 |
T6591 |
T6588 |
conj |
Burgess,Wu |
R4029 |
T6592 |
T6593 |
mark |
that,is |
R4030 |
T6593 |
T6589 |
ccomp |
is,concluded |
R4031 |
T6594 |
T6595 |
det |
the,checkpoint |
R4032 |
T6595 |
T6593 |
nsubj |
checkpoint,is |
R4033 |
T6596 |
T6595 |
compound |
repair,checkpoint |
R4034 |
T6597 |
T6598 |
compound |
RAD17,SAE2 |
R4035 |
T6598 |
T6600 |
npadvmod |
SAE2,dependent |
R4036 |
T6599 |
T6598 |
punct |
-,SAE2 |
R4037 |
T6600 |
T6593 |
acomp |
dependent,is |
R4038 |
T6601 |
T6593 |
punct |
", ",is |
R4039 |
T6602 |
T6603 |
mark |
while,is |
R4040 |
T6603 |
T6593 |
advcl |
is,is |
R4041 |
T6604 |
T6605 |
det |
the,checkpoint |
R4042 |
T6605 |
T6603 |
nsubj |
checkpoint,is |
R4043 |
T6606 |
T6605 |
compound |
synapsis,checkpoint |
R4044 |
T6607 |
T6608 |
compound |
PCH2,ZIP1 |
R4045 |
T6608 |
T6610 |
npadvmod |
ZIP1,dependent |
R4046 |
T6609 |
T6608 |
punct |
-,ZIP1 |
R4047 |
T6610 |
T6603 |
acomp |
dependent,is |
R4048 |
T6611 |
T6612 |
punct |
[,12 |
R4049 |
T6612 |
T6589 |
parataxis |
12,concluded |
R4050 |
T6613 |
T6612 |
punct |
],12 |
R4051 |
T6614 |
T6589 |
punct |
.,concluded |
R4052 |
T6616 |
T6617 |
prep |
Of,have |
R4053 |
T6618 |
T6619 |
det |
these,genes |
R4054 |
T6619 |
T6616 |
pobj |
genes,Of |
R4055 |
T6620 |
T6619 |
nummod |
four,genes |
R4056 |
T6621 |
T6617 |
punct |
", ",have |
R4057 |
T6622 |
T6617 |
nsubj |
SAE2,have |
R4058 |
T6623 |
T6622 |
cc |
and,SAE2 |
R4059 |
T6624 |
T6622 |
conj |
ZIP1,SAE2 |
R4060 |
T6625 |
T6617 |
aux |
do,have |
R4061 |
T6626 |
T6617 |
neg |
not,have |
R4062 |
T6627 |
T6628 |
amod |
clear,orthologs |
R4063 |
T6628 |
T6617 |
dobj |
orthologs,have |
R4064 |
T6629 |
T6628 |
amod |
mammalian,orthologs |
R4065 |
T6630 |
T6617 |
punct |
(,have |
R4066 |
T6631 |
T6632 |
mark |
although,be |
R4067 |
T6632 |
T6617 |
advcl |
be,have |
R4068 |
T6633 |
T6632 |
nsubj |
SYCP1,be |
R4069 |
T6634 |
T6632 |
aux |
may,be |
R4070 |
T6635 |
T6636 |
det |
a,ortholog |
R4071 |
T6636 |
T6632 |
attr |
ortholog,be |
R4072 |
T6637 |
T6636 |
amod |
functional,ortholog |
R4073 |
T6638 |
T6636 |
prep |
of,ortholog |
R4074 |
T6639 |
T6638 |
pobj |
ZIP1,of |
R4075 |
T6640 |
T6617 |
punct |
),have |
R4076 |
T6641 |
T6617 |
punct |
", ",have |
R4077 |
T6642 |
T6617 |
cc |
and,have |
R4078 |
T6643 |
T6644 |
nsubj |
mutation,causes |
R4079 |
T6644 |
T6617 |
conj |
causes,have |
R4080 |
T6645 |
T6643 |
prep |
of,mutation |
R4081 |
T6646 |
T6647 |
det |
the,ortholog |
R4082 |
T6647 |
T6645 |
pobj |
ortholog,of |
R4083 |
T6648 |
T6649 |
compound |
mouse,RAD17 |
R4084 |
T6649 |
T6647 |
compound |
RAD17,ortholog |
R4085 |
T6650 |
T6647 |
punct |
", ",ortholog |
R4086 |
T6651 |
T6647 |
appos |
Rad1,ortholog |
R4087 |
T6652 |
T6644 |
punct |
", ",causes |
R4088 |
T6653 |
T6644 |
advmod |
presumably,causes |
R4089 |
T6654 |
T6655 |
amod |
embryonic,lethality |
R4090 |
T6655 |
T6644 |
dobj |
lethality,causes |
R4091 |
T6656 |
T6657 |
punct |
[,42 |
R4092 |
T6657 |
T6644 |
parataxis |
42,causes |
R4093 |
T6658 |
T6657 |
punct |
],42 |
R4094 |
T6659 |
T6644 |
punct |
.,causes |
R4095 |
T6661 |
T6662 |
advmod |
Thus,was |
R4096 |
T6663 |
T6662 |
punct |
", ",was |
R4097 |
T6664 |
T6665 |
amod |
mutational,analysis |
R4098 |
T6665 |
T6662 |
nsubj |
analysis,was |
R4099 |
T6666 |
T6665 |
prep |
of,analysis |
R4100 |
T6667 |
T6668 |
compound |
mouse,Pch2 |
R4101 |
T6668 |
T6666 |
pobj |
Pch2,of |
R4102 |
T6669 |
T6668 |
punct |
(,Pch2 |
R4103 |
T6670 |
T6668 |
appos |
Trip13,Pch2 |
R4104 |
T6671 |
T6665 |
punct |
),analysis |
R4105 |
T6672 |
T6665 |
punct |
", ",analysis |
R4106 |
T6673 |
T6674 |
dep |
which,is |
R4107 |
T6674 |
T6665 |
relcl |
is,analysis |
R4108 |
T6675 |
T6674 |
advmod |
also,is |
R4109 |
T6676 |
T6674 |
acomp |
critical,is |
R4110 |
T6677 |
T6676 |
prep |
for,critical |
R4111 |
T6678 |
T6679 |
det |
the,checkpoint |
R4112 |
T6679 |
T6677 |
pobj |
checkpoint,for |
R4113 |
T6680 |
T6679 |
compound |
synapsis,checkpoint |
R4114 |
T6681 |
T6674 |
prep |
in,is |
R4115 |
T6682 |
T6683 |
compound |
C.,elegans |
R4116 |
T6683 |
T6681 |
pobj |
elegans,in |
R4117 |
T6684 |
T6685 |
punct |
[,2 |
R4118 |
T6685 |
T6674 |
parataxis |
2,is |
R4119 |
T6686 |
T6685 |
punct |
],2 |
R4120 |
T6687 |
T6662 |
punct |
", ",was |
R4121 |
T6688 |
T6689 |
det |
the,option |
R4122 |
T6689 |
T6662 |
attr |
option,was |
R4123 |
T6690 |
T6689 |
amod |
best,option |
R4124 |
T6691 |
T6689 |
amod |
remaining,option |
R4125 |
T6692 |
T6693 |
aux |
to,evaluate |
R4126 |
T6693 |
T6662 |
advcl |
evaluate,was |
R4127 |
T6694 |
T6695 |
amod |
potential,conservation |
R4128 |
T6695 |
T6693 |
dobj |
conservation,evaluate |
R4129 |
T6696 |
T6695 |
amod |
functional,conservation |
R4130 |
T6697 |
T6695 |
prep |
in,conservation |
R4131 |
T6698 |
T6699 |
amod |
mammalian,control |
R4132 |
T6699 |
T6697 |
pobj |
control,in |
R4133 |
T6700 |
T6701 |
amod |
meiotic,checkpoint |
R4134 |
T6701 |
T6699 |
compound |
checkpoint,control |
R4135 |
T6702 |
T6662 |
punct |
.,was |