PMC:1941754 / 30702-39198 JSON TXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

Id	Subject	Object	Predicate	Lexical cue
T6565	11-18	JJ	denotes	Genetic
T6566	19-30	NNS	denotes	experiments
T6567	48-56	VBD	denotes	provided
T6568	31-33	IN	denotes	in
T6569	34-36	NNP	denotes	S.
T6570	37-47	NNP	denotes	cerevisiae
T6571	57-65	NN	denotes	evidence
T6572	66-70	IN	denotes	that
T6573	96-104	VBZ	denotes	monitors
T6574	71-74	DT	denotes	the
T6575	85-95	NN	denotes	checkpoint
T6576	75-84	NN	denotes	pachytene
T6577	105-108	CC	denotes	and
T6578	109-117	VBZ	denotes	responds
T6579	118-120	IN	denotes	to
T6580	121-136	JJ	denotes	recombinational
T6581	141-147	NN	denotes	repair
T6582	137-140	NN	denotes	DSB
T6583	148-151	CC	denotes	and
T6584	152-160	NN	denotes	synapsis
T6585	161-174	RB	denotes	independently
T6586	174-175	.	denotes	.
T6587	175-311	sentence	denotes	Wu and Burgess concluded that the repair checkpoint is RAD17-SAE2 dependent, while the synapsis checkpoint is PCH2-ZIP1 dependent [12].
T6588	176-178	NNP	denotes	Wu
T6589	191-200	VBD	denotes	concluded
T6590	179-182	CC	denotes	and
T6591	183-190	NNP	denotes	Burgess
T6592	201-205	IN	denotes	that
T6593	228-230	VBZ	denotes	is
T6594	206-209	DT	denotes	the
T6595	217-227	NN	denotes	checkpoint
T6596	210-216	NN	denotes	repair
T6597	231-236	NN	denotes	RAD17
T6598	237-241	NN	denotes	SAE2
T6599	236-237	HYPH	denotes	-
T6600	242-251	JJ	denotes	dependent
T6601	251-253	,	denotes	,
T6602	253-258	IN	denotes	while
T6603	283-285	VBZ	denotes	is
T6604	259-262	DT	denotes	the
T6605	272-282	NN	denotes	checkpoint
T6606	263-271	NN	denotes	synapsis
T6607	286-290	NN	denotes	PCH2
T6608	291-295	NN	denotes	ZIP1
T6609	290-291	HYPH	denotes	-
T6610	296-305	JJ	denotes	dependent
T6611	306-307	-LRB-	denotes	[
T6612	307-309	CD	denotes	12
T6613	309-310	-RRB-	denotes	]
T6614	310-311	.	denotes	.
T6615	311-531	sentence	denotes	Of these four genes, SAE2 and ZIP1 do not have clear mammalian orthologs (although SYCP1 may be a functional ortholog of ZIP1), and mutation of the mouse RAD17 ortholog, Rad1, presumably causes embryonic lethality [42].
T6616	312-314	IN	denotes	Of
T6617	354-358	VB	denotes	have
T6618	315-320	DT	denotes	these
T6619	326-331	NNS	denotes	genes
T6620	321-325	CD	denotes	four
T6621	331-333	,	denotes	,
T6622	333-337	NN	denotes	SAE2
T6623	338-341	CC	denotes	and
T6624	342-346	NN	denotes	ZIP1
T6625	347-349	VBP	denotes	do
T6626	350-353	RB	denotes	not
T6627	359-364	JJ	denotes	clear
T6628	375-384	NNS	denotes	orthologs
T6629	365-374	JJ	denotes	mammalian
T6630	385-386	-LRB-	denotes	(
T6631	386-394	IN	denotes	although
T6632	405-407	VB	denotes	be
T6633	395-400	NN	denotes	SYCP1
T6634	401-404	MD	denotes	may
T6635	408-409	DT	denotes	a
T6636	421-429	NN	denotes	ortholog
T6637	410-420	JJ	denotes	functional
T6638	430-432	IN	denotes	of
T6639	433-437	NN	denotes	ZIP1
T6640	437-438	-RRB-	denotes	)
T6641	438-440	,	denotes	,
T6642	440-443	CC	denotes	and
T6643	444-452	NN	denotes	mutation
T6644	499-505	VBZ	denotes	causes
T6645	453-455	IN	denotes	of
T6646	456-459	DT	denotes	the
T6647	472-480	NN	denotes	ortholog
T6648	460-465	NN	denotes	mouse
T6649	466-471	NN	denotes	RAD17
T6650	480-482	,	denotes	,
T6651	482-486	NN	denotes	Rad1
T6652	486-488	,	denotes	,
T6653	488-498	RB	denotes	presumably
T6654	506-515	JJ	denotes	embryonic
T6655	516-525	NN	denotes	lethality
T6656	526-527	-LRB-	denotes	[
T6657	527-529	CD	denotes	42
T6658	529-530	-RRB-	denotes	]
T6659	530-531	.	denotes	.
T6660	531-768	sentence	denotes	Thus, mutational analysis of mouse Pch2 (Trip13), which is also critical for the synapsis checkpoint in C. elegans [2], was the best remaining option to evaluate potential functional conservation in mammalian meiotic checkpoint control.
T6661	532-536	RB	denotes	Thus
T6662	652-655	VBD	denotes	was
T6663	536-538	,	denotes	,
T6664	538-548	JJ	denotes	mutational
T6665	549-557	NN	denotes	analysis
T6666	558-560	IN	denotes	of
T6667	561-566	NN	denotes	mouse
T6668	567-571	NN	denotes	Pch2
T6669	572-573	-LRB-	denotes	(
T6670	573-579	NN	denotes	Trip13
T6671	579-580	-RRB-	denotes	)
T6672	580-582	,	denotes	,
T6673	582-587	WDT	denotes	which
T6674	588-590	VBZ	denotes	is
T6675	591-595	RB	denotes	also
T6676	596-604	JJ	denotes	critical
T6677	605-608	IN	denotes	for
T6678	609-612	DT	denotes	the
T6679	622-632	NN	denotes	checkpoint
T6680	613-621	NN	denotes	synapsis
T6681	633-635	IN	denotes	in
T6682	636-638	NNP	denotes	C.
T6683	639-646	NNP	denotes	elegans
T6684	647-648	-LRB-	denotes	[
T6685	648-649	CD	denotes	2
T6686	649-650	-RRB-	denotes	]
T6687	650-652	,	denotes	,
T6688	656-659	DT	denotes	the
T6689	675-681	NN	denotes	option
T6690	660-664	JJS	denotes	best
T6691	665-674	JJ	denotes	remaining
T6692	682-684	TO	denotes	to
T6693	685-693	VB	denotes	evaluate
T6694	694-703	JJ	denotes	potential
T6695	715-727	NN	denotes	conservation
T6696	704-714	JJ	denotes	functional
T6697	728-730	IN	denotes	in
T6698	731-740	JJ	denotes	mammalian
T6699	760-767	NN	denotes	control
T6700	741-748	JJ	denotes	meiotic
T6701	749-759	NN	denotes	checkpoint
T6702	767-768	.	denotes	.
T6703	768-873	sentence	denotes	Our results demonstrate that in mice, the primary meiotic function of TRIP13 is in recombination itself.
T6704	769-772	PRP$	denotes	Our
T6705	773-780	NNS	denotes	results
T6706	781-792	VBP	denotes	demonstrate
T6707	793-797	IN	denotes	that
T6708	846-848	VBZ	denotes	is
T6709	798-800	IN	denotes	in
T6710	801-805	NNS	denotes	mice
T6711	805-807	,	denotes	,
T6712	807-810	DT	denotes	the
T6713	827-835	NN	denotes	function
T6714	811-818	JJ	denotes	primary
T6715	819-826	JJ	denotes	meiotic
T6716	836-838	IN	denotes	of
T6717	839-845	NN	denotes	TRIP13
T6718	849-851	IN	denotes	in
T6719	852-865	NN	denotes	recombination
T6720	866-872	PRP	denotes	itself
T6721	872-873	.	denotes	.
T6722	873-947	sentence	denotes	We found no evidence that it is involved in pachytene checkpoint control.
T6723	874-876	PRP	denotes	We
T6724	877-882	VBD	denotes	found
T6725	883-885	DT	denotes	no
T6726	886-894	NN	denotes	evidence
T6727	895-899	IN	denotes	that
T6728	906-914	VBN	denotes	involved
T6729	900-902	PRP	denotes	it
T6730	903-905	VBZ	denotes	is
T6731	915-917	IN	denotes	in
T6732	918-927	NN	denotes	pachytene
T6733	928-938	NN	denotes	checkpoint
T6734	939-946	NN	denotes	control
T6735	946-947	.	denotes	.
T6736	947-1160	sentence	denotes	Our data suggest that while recombination events destined to be resolved as COs can proceed normally in Trip13 mutants, DSBs that enter the NCO repair pathway are incompletely resolved or processed inefficiently.
T6737	948-951	PRP$	denotes	Our
T6738	952-956	NNS	denotes	data
T6739	957-964	VBP	denotes	suggest
T6740	965-969	IN	denotes	that
T6741	1124-1132	VBN	denotes	resolved
T6742	970-975	IN	denotes	while
T6743	1032-1039	VB	denotes	proceed
T6744	976-989	NN	denotes	recombination
T6745	990-996	NNS	denotes	events
T6746	997-1005	VBN	denotes	destined
T6747	1006-1008	TO	denotes	to
T6748	1012-1020	VBN	denotes	resolved
T6749	1009-1011	VB	denotes	be
T6750	1021-1023	IN	denotes	as
T6751	1024-1027	NNS	denotes	COs
T6752	1028-1031	MD	denotes	can
T6753	1040-1048	RB	denotes	normally
T6754	1049-1051	IN	denotes	in
T6755	1052-1058	NN	denotes	Trip13
T6756	1059-1066	NNS	denotes	mutants
T6757	1066-1068	,	denotes	,
T6758	1068-1072	NNS	denotes	DSBs
T6759	1073-1077	WDT	denotes	that
T6760	1078-1083	VBP	denotes	enter
T6761	1084-1087	DT	denotes	the
T6762	1099-1106	NN	denotes	pathway
T6763	1088-1091	NN	denotes	NCO
T6764	1092-1098	NN	denotes	repair
T6765	1107-1110	VBP	denotes	are
T6766	1111-1123	RB	denotes	incompletely
T6767	1133-1135	CC	denotes	or
T6768	1136-1145	VBN	denotes	processed
T6769	1146-1159	RB	denotes	inefficiently
T6770	1159-1160	.	denotes	.
T6771	1160-1248	sentence	denotes	This hypothesis is compatible with current knowledge of meiotic recombination pathways.
T6772	1161-1165	DT	denotes	This
T6773	1166-1176	NN	denotes	hypothesis
T6774	1177-1179	VBZ	denotes	is
T6775	1180-1190	JJ	denotes	compatible
T6776	1191-1195	IN	denotes	with
T6777	1196-1203	JJ	denotes	current
T6778	1204-1213	NN	denotes	knowledge
T6779	1214-1216	IN	denotes	of
T6780	1217-1224	JJ	denotes	meiotic
T6781	1225-1238	NN	denotes	recombination
T6782	1239-1247	NNS	denotes	pathways
T6783	1247-1248	.	denotes	.
T6784	1248-1405	sentence	denotes	In S. cerevisiae, CO and NCO pathways are distinct [43]; they have different recombination intermediates, and are dependent upon different proteins [44,45].
T6785	1249-1251	IN	denotes	In
T6786	1287-1290	VBP	denotes	are
T6787	1252-1254	NNP	denotes	S.
T6788	1255-1265	NNP	denotes	cerevisiae
T6789	1265-1267	,	denotes	,
T6790	1267-1269	NN	denotes	CO
T6791	1278-1286	NNS	denotes	pathways
T6792	1270-1273	CC	denotes	and
T6793	1274-1277	NN	denotes	NCO
T6794	1311-1315	VBP	denotes	have
T6795	1291-1299	JJ	denotes	distinct
T6796	1300-1301	-LRB-	denotes	[
T6797	1301-1303	CD	denotes	43
T6798	1303-1304	-RRB-	denotes	]
T6799	1304-1305	:	denotes	;
T6800	1306-1310	PRP	denotes	they
T6801	1316-1325	JJ	denotes	different
T6802	1340-1353	NNS	denotes	intermediates
T6803	1326-1339	NN	denotes	recombination
T6804	1353-1355	,	denotes	,
T6805	1355-1358	CC	denotes	and
T6806	1359-1362	VBP	denotes	are
T6807	1363-1372	JJ	denotes	dependent
T6808	1373-1377	IN	denotes	upon
T6809	1378-1387	JJ	denotes	different
T6810	1388-1396	NN	denotes	proteins
T6811	1397-1398	-LRB-	denotes	[
T6812	1401-1403	CD	denotes	45
T6813	1398-1400	CD	denotes	44
T6814	1400-1401	,	denotes	,
T6815	1403-1404	-RRB-	denotes	]
T6816	1404-1405	.	denotes	.
T6817	1405-1485	sentence	denotes	Mice also appear to have independent CO versus NCO recombination pathways [46].
T6818	1406-1410	NNS	denotes	Mice
T6819	1416-1422	VBP	denotes	appear
T6820	1411-1415	RB	denotes	also
T6821	1423-1425	TO	denotes	to
T6822	1426-1430	VB	denotes	have
T6823	1431-1442	JJ	denotes	independent
T6824	1471-1479	NNS	denotes	pathways
T6825	1443-1445	NN	denotes	CO
T6826	1446-1452	CC	denotes	versus
T6827	1453-1456	NN	denotes	NCO
T6828	1457-1470	NN	denotes	recombination
T6829	1480-1481	-LRB-	denotes	[
T6830	1481-1483	CD	denotes	46
T6831	1483-1484	-RRB-	denotes	]
T6832	1484-1485	.	denotes	.
T6833	1485-1572	sentence	denotes	As in yeast, both require SPO11-induced breaks, but only the CO pathway requires MLH1.
T6834	1486-1488	IN	denotes	As
T6835	1504-1511	VBP	denotes	require
T6836	1489-1491	IN	denotes	in
T6837	1492-1497	NN	denotes	yeast
T6838	1497-1499	,	denotes	,
T6839	1499-1503	DT	denotes	both
T6840	1512-1517	NN	denotes	SPO11
T6841	1518-1525	VBN	denotes	induced
T6842	1517-1518	HYPH	denotes	-
T6843	1526-1532	NNS	denotes	breaks
T6844	1532-1534	,	denotes	,
T6845	1534-1537	CC	denotes	but
T6846	1538-1542	RB	denotes	only
T6847	1550-1557	NN	denotes	pathway
T6848	1543-1546	DT	denotes	the
T6849	1547-1549	NN	denotes	CO
T6850	1558-1566	VBZ	denotes	requires
T6851	1567-1571	NN	denotes	MLH1
T6852	1571-1572	.	denotes	.
T6853	1572-1641	sentence	denotes	Both types of recombinant products are formed by mid-late pachynema.
T6854	1573-1577	DT	denotes	Both
T6855	1578-1583	NNS	denotes	types
T6856	1612-1618	VBN	denotes	formed
T6857	1584-1586	IN	denotes	of
T6858	1587-1598	JJ	denotes	recombinant
T6859	1599-1607	NNS	denotes	products
T6860	1608-1611	VBP	denotes	are
T6861	1619-1621	IN	denotes	by
T6862	1622-1625	JJ	denotes	mid
T6863	1626-1630	JJ	denotes	late
T6864	1625-1626	SYM	denotes	-
T6865	1631-1640	NN	denotes	pachynema
T6866	1640-1641	.	denotes	.
T6867	1641-1748	sentence	denotes	Another possibility is that the recombination defects are a result of defective intersister recombination.
T6868	1642-1649	DT	denotes	Another
T6869	1650-1661	NN	denotes	possibility
T6870	1662-1664	VBZ	denotes	is
T6871	1665-1669	IN	denotes	that
T6872	1696-1699	VBP	denotes	are
T6873	1670-1673	DT	denotes	the
T6874	1688-1695	NNS	denotes	defects
T6875	1674-1687	NN	denotes	recombination
T6876	1700-1701	DT	denotes	a
T6877	1702-1708	NN	denotes	result
T6878	1709-1711	IN	denotes	of
T6879	1712-1721	JJ	denotes	defective
T6880	1734-1747	NN	denotes	recombination
T6881	1722-1733	JJ	denotes	intersister
T6882	1747-1748	.	denotes	.
T6883	1748-1813	sentence	denotes	However, this type of DSB repair is suppressed in meiotic cells.
T6884	1749-1756	RB	denotes	However
T6885	1785-1795	VBN	denotes	suppressed
T6886	1756-1758	,	denotes	,
T6887	1758-1762	DT	denotes	this
T6888	1763-1767	NN	denotes	type
T6889	1768-1770	IN	denotes	of
T6890	1771-1774	NN	denotes	DSB
T6891	1775-1781	NN	denotes	repair
T6892	1782-1784	VBZ	denotes	is
T6893	1796-1798	IN	denotes	in
T6894	1799-1806	JJ	denotes	meiotic
T6895	1807-1812	NNS	denotes	cells
T6896	1812-1813	.	denotes	.
T6897	1813-1955	sentence	denotes	Ablation of RAD54, which mediates intersister recombination in yeast, does not significantly disrupt meiosis in either yeast or mice [47,48].
T6898	1814-1822	NN	denotes	Ablation
T6899	1907-1914	VB	denotes	disrupt
T6900	1823-1825	IN	denotes	of
T6901	1826-1831	NN	denotes	RAD54
T6902	1831-1833	,	denotes	,
T6903	1833-1838	WDT	denotes	which
T6904	1839-1847	VBZ	denotes	mediates
T6905	1848-1859	JJ	denotes	intersister
T6906	1860-1873	NN	denotes	recombination
T6907	1874-1876	IN	denotes	in
T6908	1877-1882	NN	denotes	yeast
T6909	1882-1884	,	denotes	,
T6910	1884-1888	VBZ	denotes	does
T6911	1889-1892	RB	denotes	not
T6912	1893-1906	RB	denotes	significantly
T6913	1915-1922	NN	denotes	meiosis
T6914	1923-1925	IN	denotes	in
T6915	1926-1932	CC	denotes	either
T6916	1933-1938	NN	denotes	yeast
T6917	1939-1941	CC	denotes	or
T6918	1942-1946	NNS	denotes	mice
T6919	1947-1948	-LRB-	denotes	[
T6920	1951-1953	CD	denotes	48
T6921	1948-1950	CD	denotes	47
T6922	1950-1951	,	denotes	,
T6923	1953-1954	-RRB-	denotes	]
T6924	1954-1955	.	denotes	.
T6925	1955-2181	sentence	denotes	Interestingly, RAD54-deficient spermatocytes display abnormal persistence of RAD51 foci on pachytene chromosomes, similar to those in TRIP13 mice, but there are no deleterious effects on meiotic progression or fertility [49].
T6926	1956-1969	RB	denotes	Interestingly
T6927	2001-2008	VBP	denotes	display
T6928	1969-1971	,	denotes	,
T6929	1971-1976	NN	denotes	RAD54
T6930	1977-1986	JJ	denotes	deficient
T6931	1976-1977	HYPH	denotes	-
T6932	1987-2000	NNS	denotes	spermatocytes
T6933	2009-2017	JJ	denotes	abnormal
T6934	2018-2029	NN	denotes	persistence
T6935	2030-2032	IN	denotes	of
T6936	2033-2038	NN	denotes	RAD51
T6937	2039-2043	NNS	denotes	foci
T6938	2044-2046	IN	denotes	on
T6939	2047-2056	NN	denotes	pachytene
T6940	2057-2068	NNS	denotes	chromosomes
T6941	2068-2070	,	denotes	,
T6942	2070-2077	JJ	denotes	similar
T6943	2078-2080	IN	denotes	to
T6944	2081-2086	DT	denotes	those
T6945	2087-2089	IN	denotes	in
T6946	2090-2096	NN	denotes	TRIP13
T6947	2097-2101	NNS	denotes	mice
T6948	2101-2103	,	denotes	,
T6949	2103-2106	CC	denotes	but
T6950	2107-2112	EX	denotes	there
T6951	2113-2116	VBP	denotes	are
T6952	2117-2119	DT	denotes	no
T6953	2132-2139	NNS	denotes	effects
T6954	2120-2131	JJ	denotes	deleterious
T6955	2140-2142	IN	denotes	on
T6956	2143-2150	JJ	denotes	meiotic
T6957	2151-2162	NN	denotes	progression
T6958	2163-2165	CC	denotes	or
T6959	2166-2175	NN	denotes	fertility
T6960	2176-2177	-LRB-	denotes	[
T6961	2177-2179	CD	denotes	49
T6962	2179-2180	-RRB-	denotes	]
T6963	2180-2181	.	denotes	.
T6964	2181-2258	sentence	denotes	Data from budding yeast also indicate that Pch2p functions in recombination.
T6965	2182-2186	NNS	denotes	Data
T6966	2211-2219	VBP	denotes	indicate
T6967	2187-2191	IN	denotes	from
T6968	2192-2199	VBG	denotes	budding
T6969	2200-2205	NN	denotes	yeast
T6970	2206-2210	RB	denotes	also
T6971	2220-2224	IN	denotes	that
T6972	2231-2240	VBZ	denotes	functions
T6973	2225-2230	NN	denotes	Pch2p
T6974	2241-2243	IN	denotes	in
T6975	2244-2257	NN	denotes	recombination
T6976	2257-2258	.	denotes	.
T6977	2258-2377	sentence	denotes	Deletion of PCH2 delays meiotic progression by ∼2 h in SK1 yeast, and causes a minor decrease in ascus formation [50].
T6978	2259-2267	NN	denotes	Deletion
T6979	2276-2282	VBZ	denotes	delays
T6980	2268-2270	IN	denotes	of
T6981	2271-2275	NN	denotes	PCH2
T6982	2283-2290	JJ	denotes	meiotic
T6983	2291-2302	NN	denotes	progression
T6984	2303-2305	IN	denotes	by
T6985	2306-2307	SYM	denotes	∼
T6986	2307-2308	CD	denotes	2
T6987	2309-2310	NN	denotes	h
T6988	2311-2313	IN	denotes	in
T6989	2314-2317	NN	denotes	SK1
T6990	2318-2323	NN	denotes	yeast
T6991	2323-2325	,	denotes	,
T6992	2325-2328	CC	denotes	and
T6993	2329-2335	VBZ	denotes	causes
T6994	2336-2337	DT	denotes	a
T6995	2344-2352	NN	denotes	decrease
T6996	2338-2343	JJ	denotes	minor
T6997	2353-2355	IN	denotes	in
T6998	2356-2361	NN	denotes	ascus
T6999	2362-2371	NN	denotes	formation
T7000	2372-2373	-LRB-	denotes	[
T7001	2373-2375	CD	denotes	50
T7002	2375-2376	-RRB-	denotes	]
T7003	2376-2377	.	denotes	.
T7004	2377-2528	sentence	denotes	DSBs persist >2 h longer in pch2Δ yeast than in wild type, and hyperresection of DSBs in dmc1Δ pch2Δ double mutants is lower than in dmc1Δ cells [10].
T7005	2378-2382	NNS	denotes	DSBs
T7006	2383-2390	VBP	denotes	persist
T7007	2391-2392	SYM	denotes	>
T7008	2392-2393	CD	denotes	2
T7009	2394-2395	NN	denotes	h
T7010	2396-2402	RBR	denotes	longer
T7011	2403-2405	IN	denotes	in
T7012	2406-2410	NN	denotes	pch2
T7013	2412-2417	NN	denotes	yeast
T7014	2410-2411	SYM	denotes	Δ
T7015	2418-2422	IN	denotes	than
T7016	2423-2425	IN	denotes	in
T7017	2426-2430	JJ	denotes	wild
T7018	2431-2435	NN	denotes	type
T7019	2435-2437	,	denotes	,
T7020	2437-2440	CC	denotes	and
T7021	2441-2455	NN	denotes	hyperresection
T7022	2494-2496	VBZ	denotes	is
T7023	2456-2458	IN	denotes	of
T7024	2459-2463	NNS	denotes	DSBs
T7025	2464-2466	IN	denotes	in
T7026	2467-2471	NN	denotes	dmc1
T7027	2473-2477	NN	denotes	pch2
T7028	2471-2472	SYM	denotes	Δ
T7029	2486-2493	NNS	denotes	mutants
T7030	2477-2478	SYM	denotes	Δ
T7031	2479-2485	JJ	denotes	double
T7032	2497-2502	JJR	denotes	lower
T7033	2503-2507	IN	denotes	than
T7034	2508-2510	IN	denotes	in
T7035	2511-2515	NN	denotes	dmc1
T7036	2517-2522	NNS	denotes	cells
T7037	2515-2516	SYM	denotes	Δ
T7038	2523-2524	-LRB-	denotes	[
T7039	2524-2526	CD	denotes	10
T7040	2526-2527	-RRB-	denotes	]
T7041	2527-2528	.	denotes	.
T7042	2528-2684	sentence	denotes	Additionally, it was reported that pch2Δ yeast had a meiosis I delay dependent on the RAD17–SAE2 checkpoint that monitors recombination intermediates [12].
T7043	2529-2541	RB	denotes	Additionally
T7044	2550-2558	VBN	denotes	reported
T7045	2541-2543	,	denotes	,
T7046	2543-2545	PRP	denotes	it
T7047	2546-2549	VBD	denotes	was
T7048	2559-2563	IN	denotes	that
T7049	2576-2579	VBD	denotes	had
T7050	2564-2568	NN	denotes	pch2
T7051	2568-2569	NN	denotes	Δ
T7052	2570-2575	NN	denotes	yeast
T7053	2580-2581	DT	denotes	a
T7054	2592-2597	NN	denotes	delay
T7055	2582-2589	NN	denotes	meiosis
T7056	2590-2591	CD	denotes	I
T7057	2598-2607	JJ	denotes	dependent
T7058	2608-2610	IN	denotes	on
T7059	2611-2614	DT	denotes	the
T7060	2626-2636	NN	denotes	checkpoint
T7061	2615-2620	NN	denotes	RAD17
T7062	2621-2625	NN	denotes	SAE2
T7063	2620-2621	HYPH	denotes	–
T7064	2637-2641	WDT	denotes	that
T7065	2642-2650	VBZ	denotes	monitors
T7066	2651-2664	NN	denotes	recombination
T7067	2665-2678	NNS	denotes	intermediates
T7068	2679-2680	-LRB-	denotes	[
T7069	2680-2682	CD	denotes	12
T7070	2682-2683	-RRB-	denotes	]
T7071	2683-2684	.	denotes	.
T7072	2684-2757	sentence	denotes	However, the exact role of TRIP13 (or Pch2) in recombination is unclear.
T7073	2685-2692	RB	denotes	However
T7074	2746-2748	VBZ	denotes	is
T7075	2692-2694	,	denotes	,
T7076	2694-2697	DT	denotes	the
T7077	2704-2708	NN	denotes	role
T7078	2698-2703	JJ	denotes	exact
T7079	2709-2711	IN	denotes	of
T7080	2712-2718	NN	denotes	TRIP13
T7081	2719-2720	-LRB-	denotes	(
T7082	2720-2722	CC	denotes	or
T7083	2723-2727	NN	denotes	Pch2
T7084	2727-2728	-RRB-	denotes	)
T7085	2729-2731	IN	denotes	in
T7086	2732-2745	NN	denotes	recombination
T7087	2749-2756	JJ	denotes	unclear
T7088	2756-2757	.	denotes	.
T7089	2757-3110	sentence	denotes	Because synapsis occurs in TRIP13-deficient spermatocytes and is dependent on DSB formation (activity of SPO11 and MEI1), we suggest that TRIP13 functions after homology recognition and strand exchange, and that recombination events entering the CO repair pathway are either completed or nearly so (because OA treated resulted in bivalent chromosomes).
T7090	2758-2765	IN	denotes	Because
T7091	2775-2781	VBZ	denotes	occurs
T7092	2766-2774	NN	denotes	synapsis
T7093	2883-2890	VBP	denotes	suggest
T7094	2782-2784	IN	denotes	in
T7095	2785-2791	NN	denotes	TRIP13
T7096	2792-2801	JJ	denotes	deficient
T7097	2791-2792	HYPH	denotes	-
T7098	2802-2815	NNS	denotes	spermatocytes
T7099	2816-2819	CC	denotes	and
T7100	2820-2822	VBZ	denotes	is
T7101	2823-2832	JJ	denotes	dependent
T7102	2833-2835	IN	denotes	on
T7103	2836-2839	NN	denotes	DSB
T7104	2840-2849	NN	denotes	formation
T7105	2850-2851	-LRB-	denotes	(
T7106	2851-2859	NN	denotes	activity
T7107	2860-2862	IN	denotes	of
T7108	2863-2868	NN	denotes	SPO11
T7109	2869-2872	CC	denotes	and
T7110	2873-2877	NN	denotes	MEI1
T7111	2877-2878	-RRB-	denotes	)
T7112	2878-2880	,	denotes	,
T7113	2880-2882	PRP	denotes	we
T7114	2891-2895	IN	denotes	that
T7115	2903-2912	VBZ	denotes	functions
T7116	2896-2902	NN	denotes	TRIP13
T7117	2913-2918	IN	denotes	after
T7118	2919-2927	NN	denotes	homology
T7119	2928-2939	NN	denotes	recognition
T7120	2940-2943	CC	denotes	and
T7121	2944-2950	NN	denotes	strand
T7122	2951-2959	NN	denotes	exchange
T7123	2959-2961	,	denotes	,
T7124	2961-2964	CC	denotes	and
T7125	2965-2969	IN	denotes	that
T7126	3022-3025	VBP	denotes	are
T7127	2970-2983	NN	denotes	recombination
T7128	2984-2990	NNS	denotes	events
T7129	2991-2999	VBG	denotes	entering
T7130	3000-3003	DT	denotes	the
T7131	3014-3021	NN	denotes	pathway
T7132	3004-3006	NN	denotes	CO
T7133	3007-3013	NN	denotes	repair
T7134	3026-3032	RB	denotes	either
T7135	3033-3042	VBN	denotes	completed
T7136	3043-3045	CC	denotes	or
T7137	3046-3052	RB	denotes	nearly
T7138	3053-3055	RB	denotes	so
T7139	3056-3057	-LRB-	denotes	(
T7140	3057-3064	IN	denotes	because
T7141	3076-3084	VBD	denotes	resulted
T7142	3065-3067	NN	denotes	OA
T7143	3068-3075	VBN	denotes	treated
T7144	3085-3087	IN	denotes	in
T7145	3088-3096	JJ	denotes	bivalent
T7146	3097-3108	NNS	denotes	chromosomes
T7147	3108-3109	-RRB-	denotes	)
T7148	3109-3110	.	denotes	.
T7149	3110-3262	sentence	denotes	One possibility for TRIP13′s role in recombination is that it is directly involved in a step specific to resolution of NCO recombination intermediates.
T7150	3111-3114	CD	denotes	One
T7151	3115-3126	NN	denotes	possibility
T7152	3162-3164	VBZ	denotes	is
T7153	3127-3130	IN	denotes	for
T7154	3131-3137	NN	denotes	TRIP13
T7155	3140-3144	NN	denotes	role
T7156	3137-3139	POS	denotes	′s
T7157	3145-3147	IN	denotes	in
T7158	3148-3161	NN	denotes	recombination
T7159	3165-3169	IN	denotes	that
T7160	3185-3193	VBN	denotes	involved
T7161	3170-3172	PRP	denotes	it
T7162	3173-3175	VBZ	denotes	is
T7163	3176-3184	RB	denotes	directly
T7164	3194-3196	IN	denotes	in
T7165	3197-3198	DT	denotes	a
T7166	3199-3203	NN	denotes	step
T7167	3204-3212	JJ	denotes	specific
T7168	3213-3215	IN	denotes	to
T7169	3216-3226	NN	denotes	resolution
T7170	3227-3229	IN	denotes	of
T7171	3230-3233	NN	denotes	NCO
T7172	3234-3247	NN	denotes	recombination
T7173	3248-3261	NNS	denotes	intermediates
T7174	3261-3262	.	denotes	.
T7175	3262-3458	sentence	denotes	Another possibility is that TRIP13 is required for disassembly of NCO recombinational repair complexes [51] containing those proteins that persist abnormally on Trip13Gt/Gt pachytene chromosomes.
T7176	3263-3270	DT	denotes	Another
T7177	3271-3282	NN	denotes	possibility
T7178	3283-3285	VBZ	denotes	is
T7179	3286-3290	IN	denotes	that
T7180	3301-3309	VBN	denotes	required
T7181	3291-3297	NN	denotes	TRIP13
T7182	3298-3300	VBZ	denotes	is
T7183	3310-3313	IN	denotes	for
T7184	3314-3325	NN	denotes	disassembly
T7185	3326-3328	IN	denotes	of
T7186	3329-3332	NN	denotes	NCO
T7187	3333-3348	JJ	denotes	recombinational
T7188	3349-3355	NN	denotes	repair
T7189	3356-3365	NNS	denotes	complexes
T7190	3366-3367	-LRB-	denotes	[
T7191	3367-3369	CD	denotes	51
T7192	3369-3370	-RRB-	denotes	]
T7193	3371-3381	VBG	denotes	containing
T7194	3382-3387	DT	denotes	those
T7195	3388-3396	NN	denotes	proteins
T7196	3397-3401	WDT	denotes	that
T7197	3402-3409	VBP	denotes	persist
T7198	3410-3420	RB	denotes	abnormally
T7199	3421-3423	IN	denotes	on
T7200	3424-3432	NN	denotes	Trip13Gt
T7201	3433-3435	NN	denotes	Gt
T7202	3432-3433	HYPH	denotes	/
T7203	3446-3457	NNS	denotes	chromosomes
T7204	3436-3445	NN	denotes	pachytene
T7205	3457-3458	.	denotes	.
T7206	3458-3613	sentence	denotes	Notably, TRIP13 has two putative ATPase domains, a signature of AAA-ATPase ClpA/B chaperones that perform protein or protein/DNA complex disassembly [52].
T7207	3459-3466	RB	denotes	Notably
T7208	3475-3478	VBZ	denotes	has
T7209	3466-3468	,	denotes	,
T7210	3468-3474	NN	denotes	TRIP13
T7211	3479-3482	CD	denotes	two
T7212	3499-3506	NNS	denotes	domains
T7213	3483-3491	JJ	denotes	putative
T7214	3492-3498	NN	denotes	ATPase
T7215	3506-3508	,	denotes	,
T7216	3508-3509	DT	denotes	a
T7217	3510-3519	NN	denotes	signature
T7218	3520-3522	IN	denotes	of
T7219	3523-3526	NN	denotes	AAA
T7220	3527-3533	NN	denotes	ATPase
T7221	3526-3527	HYPH	denotes	-
T7222	3541-3551	NNS	denotes	chaperones
T7223	3534-3538	NN	denotes	ClpA
T7224	3539-3540	NN	denotes	B
T7225	3538-3539	HYPH	denotes	/
T7226	3552-3556	WDT	denotes	that
T7227	3557-3564	VBP	denotes	perform
T7228	3565-3572	NN	denotes	protein
T7229	3596-3607	NN	denotes	disassembly
T7230	3573-3575	CC	denotes	or
T7231	3576-3583	NN	denotes	protein
T7232	3584-3587	NN	denotes	DNA
T7233	3583-3584	HYPH	denotes	/
T7234	3588-3595	NN	denotes	complex
T7235	3608-3609	-LRB-	denotes	[
T7236	3609-3611	CD	denotes	52
T7237	3611-3612	-RRB-	denotes	]
T7238	3612-3613	.	denotes	.
T7239	3613-3773	sentence	denotes	These potential recombination roles might not be limited to meiosis, since Trip13 is widely transcribed and the mutant animals exhibited developmental defects.
T7240	3614-3619	DT	denotes	These
T7241	3644-3649	NNS	denotes	roles
T7242	3620-3629	JJ	denotes	potential
T7243	3630-3643	NN	denotes	recombination
T7244	3663-3670	VBN	denotes	limited
T7245	3650-3655	MD	denotes	might
T7246	3656-3659	RB	denotes	not
T7247	3660-3662	VB	denotes	be
T7248	3671-3673	IN	denotes	to
T7249	3674-3681	NN	denotes	meiosis
T7250	3681-3683	,	denotes	,
T7251	3683-3688	IN	denotes	since
T7252	3706-3717	VBN	denotes	transcribed
T7253	3689-3695	NN	denotes	Trip13
T7254	3696-3698	VBZ	denotes	is
T7255	3699-3705	RB	denotes	widely
T7256	3718-3721	CC	denotes	and
T7257	3722-3725	DT	denotes	the
T7258	3733-3740	NNS	denotes	animals
T7259	3726-3732	NN	denotes	mutant
T7260	3741-3750	VBD	denotes	exhibited
T7261	3751-3764	JJ	denotes	developmental
T7262	3765-3772	NNS	denotes	defects
T7263	3772-3773	.	denotes	.
T7264	3773-3924	sentence	denotes	Finally, TRIP13 might play an indirect role, such as providing a “licensing” signal for the resolution of NCO intermediates and completion of meiosis.
T7265	3774-3781	RB	denotes	Finally
T7266	3796-3800	VB	denotes	play
T7267	3781-3783	,	denotes	,
T7268	3783-3789	NN	denotes	TRIP13
T7269	3790-3795	MD	denotes	might
T7270	3801-3803	DT	denotes	an
T7271	3813-3817	NN	denotes	role
T7272	3804-3812	JJ	denotes	indirect
T7273	3817-3819	,	denotes	,
T7274	3819-3823	JJ	denotes	such
T7275	3824-3826	IN	denotes	as
T7276	3827-3836	VBG	denotes	providing
T7277	3837-3838	DT	denotes	a
T7278	3851-3857	NN	denotes	signal
T7279	3839-3840	``	denotes	“
T7280	3840-3849	NN	denotes	licensing
T7281	3849-3850	''	denotes	”
T7282	3858-3861	IN	denotes	for
T7283	3862-3865	DT	denotes	the
T7284	3866-3876	NN	denotes	resolution
T7285	3877-3879	IN	denotes	of
T7286	3880-3883	NN	denotes	NCO
T7287	3884-3897	NNS	denotes	intermediates
T7288	3898-3901	CC	denotes	and
T7289	3902-3912	NN	denotes	completion
T7290	3913-3915	IN	denotes	of
T7291	3916-3923	NN	denotes	meiosis
T7292	3923-3924	.	denotes	.
T7293	3924-4065	sentence	denotes	Regarding the cause of cell death in Trip13 mutants, our data indicate that this is triggered by defective DSB repair rather than asynapsis.
T7294	3925-3934	VBG	denotes	Regarding
T7295	3987-3995	VBP	denotes	indicate
T7296	3935-3938	DT	denotes	the
T7297	3939-3944	NN	denotes	cause
T7298	3945-3947	IN	denotes	of
T7299	3948-3952	NN	denotes	cell
T7300	3953-3958	NN	denotes	death
T7301	3959-3961	IN	denotes	in
T7302	3962-3968	NN	denotes	Trip13
T7303	3969-3976	NNS	denotes	mutants
T7304	3976-3978	,	denotes	,
T7305	3978-3981	PRP$	denotes	our
T7306	3982-3986	NNS	denotes	data
T7307	3996-4000	IN	denotes	that
T7308	4009-4018	VBN	denotes	triggered
T7309	4001-4005	DT	denotes	this
T7310	4006-4008	VBZ	denotes	is
T7311	4019-4021	IN	denotes	by
T7312	4022-4031	JJ	denotes	defective
T7313	4036-4042	NN	denotes	repair
T7314	4032-4035	NN	denotes	DSB
T7315	4043-4049	RB	denotes	rather
T7316	4050-4054	IN	denotes	than
T7317	4055-4064	NN	denotes	asynapsis
T7318	4064-4065	.	denotes	.
T7319	4065-4226	sentence	denotes	We base this conclusion on two observations: (1) oocyte elimination is dependent upon DSB formation and (2) synapsis is normal in spermatocytes of adult testes.
T7320	4066-4068	PRP	denotes	We
T7321	4069-4073	VBP	denotes	base
T7322	4134-4136	VBZ	denotes	is
T7323	4074-4078	DT	denotes	this
T7324	4079-4089	NN	denotes	conclusion
T7325	4090-4092	IN	denotes	on
T7326	4093-4096	CD	denotes	two
T7327	4097-4109	NNS	denotes	observations
T7328	4109-4111	:	denotes	:
T7329	4111-4112	-LRB-	denotes	(
T7330	4112-4113	LS	denotes	1
T7331	4113-4114	-RRB-	denotes	)
T7332	4115-4121	NN	denotes	oocyte
T7333	4122-4133	NN	denotes	elimination
T7334	4137-4146	JJ	denotes	dependent
T7335	4147-4151	IN	denotes	upon
T7336	4152-4155	NN	denotes	DSB
T7337	4156-4165	NN	denotes	formation
T7338	4166-4169	CC	denotes	and
T7339	4170-4171	-LRB-	denotes	(
T7340	4171-4172	LS	denotes	2
T7341	4183-4185	VBZ	denotes	is
T7342	4172-4173	-RRB-	denotes	)
T7343	4174-4182	NN	denotes	synapsis
T7344	4186-4192	JJ	denotes	normal
T7345	4193-4195	IN	denotes	in
T7346	4196-4209	NNS	denotes	spermatocytes
T7347	4210-4212	IN	denotes	of
T7348	4213-4218	JJ	denotes	adult
T7349	4219-4225	NNS	denotes	testes
T7350	4225-4226	.	denotes	.
T7351	4226-4350	sentence	denotes	Indeed, this mutant is unique in that recombination defects occur in the absence of asynapsis (e.g., as in Dmc1 knockouts).
T7352	4227-4233	RB	denotes	Indeed
T7353	4247-4249	VBZ	denotes	is
T7354	4233-4235	,	denotes	,
T7355	4235-4239	DT	denotes	this
T7356	4240-4246	NN	denotes	mutant
T7357	4250-4256	JJ	denotes	unique
T7358	4257-4259	IN	denotes	in
T7359	4287-4292	VBP	denotes	occur
T7360	4260-4264	IN	denotes	that
T7361	4265-4278	NN	denotes	recombination
T7362	4279-4286	NNS	denotes	defects
T7363	4293-4295	IN	denotes	in
T7364	4296-4299	DT	denotes	the
T7365	4300-4307	NN	denotes	absence
T7366	4308-4310	IN	denotes	of
T7367	4311-4320	NN	denotes	asynapsis
T7368	4321-4322	-LRB-	denotes	(
T7369	4328-4330	IN	denotes	as
T7370	4322-4326	FW	denotes	e.g.
T7371	4326-4328	,	denotes	,
T7372	4331-4333	IN	denotes	in
T7373	4334-4338	NN	denotes	Dmc1
T7374	4339-4348	NNS	denotes	knockouts
T7375	4348-4349	-RRB-	denotes	)
T7376	4349-4350	.	denotes	.
T7377	4350-4492	sentence	denotes	Thus, the Trip13 mutant provides the first evidence that unrepaired DNA damage alone can trigger the mammalian pachytene checkpoint response.
T7378	4351-4355	RB	denotes	Thus
T7379	4375-4383	VBZ	denotes	provides
T7380	4355-4357	,	denotes	,
T7381	4357-4360	DT	denotes	the
T7382	4368-4374	NN	denotes	mutant
T7383	4361-4367	NN	denotes	Trip13
T7384	4384-4387	DT	denotes	the
T7385	4394-4402	NN	denotes	evidence
T7386	4388-4393	JJ	denotes	first
T7387	4403-4407	IN	denotes	that
T7388	4440-4447	VB	denotes	trigger
T7389	4408-4418	JJ	denotes	unrepaired
T7390	4423-4429	NN	denotes	damage
T7391	4419-4422	NN	denotes	DNA
T7392	4430-4435	RB	denotes	alone
T7393	4436-4439	MD	denotes	can
T7394	4448-4451	DT	denotes	the
T7395	4483-4491	NN	denotes	response
T7396	4452-4461	JJ	denotes	mammalian
T7397	4462-4471	NN	denotes	pachytene
T7398	4472-4482	NN	denotes	checkpoint
T7399	4491-4492	.	denotes	.
T7400	4492-4682	sentence	denotes	Furthermore, our results allow us to conclude that oocytes and spermatocytes share a similar, if not identical, DNA damage pachytene checkpoint that is decoupled from a synapsis checkpoint.
T7401	4493-4504	RB	denotes	Furthermore
T7402	4518-4523	VBP	denotes	allow
T7403	4504-4506	,	denotes	,
T7404	4506-4509	PRP$	denotes	our
T7405	4510-4517	NNS	denotes	results
T7406	4524-4526	PRP	denotes	us
T7407	4530-4538	VB	denotes	conclude
T7408	4527-4529	TO	denotes	to
T7409	4539-4543	IN	denotes	that
T7410	4570-4575	VBP	denotes	share
T7411	4544-4551	NNS	denotes	oocytes
T7412	4552-4555	CC	denotes	and
T7413	4556-4569	NNS	denotes	spermatocytes
T7414	4576-4577	DT	denotes	a
T7415	4626-4636	NN	denotes	checkpoint
T7416	4578-4585	JJ	denotes	similar
T7417	4585-4587	,	denotes	,
T7418	4587-4589	IN	denotes	if
T7419	4590-4593	RB	denotes	not
T7420	4594-4603	JJ	denotes	identical
T7421	4603-4605	,	denotes	,
T7422	4605-4608	NN	denotes	DNA
T7423	4609-4615	NN	denotes	damage
T7424	4616-4625	NN	denotes	pachytene
T7425	4637-4641	WDT	denotes	that
T7426	4645-4654	VBN	denotes	decoupled
T7427	4642-4644	VBZ	denotes	is
T7428	4655-4659	IN	denotes	from
T7429	4660-4661	DT	denotes	a
T7430	4671-4681	NN	denotes	checkpoint
T7431	4662-4670	NN	denotes	synapsis
T7432	4681-4682	.	denotes	.
T7433	4682-4941	sentence	denotes	Interestingly, we found that OA treatment of Trip13Gt/Gt spermatocytes could propel them into MI, despite a report that the same did not occur when wild-type pachytene spermatocytes were treated with the DSB-inducing agents gamma radiation or etoposide [53].
T7434	4683-4696	RB	denotes	Interestingly
T7435	4701-4706	VBD	denotes	found
T7436	4696-4698	,	denotes	,
T7437	4698-4700	PRP	denotes	we
T7438	4707-4711	IN	denotes	that
T7439	4760-4766	VB	denotes	propel
T7440	4712-4714	NN	denotes	OA
T7441	4715-4724	NN	denotes	treatment
T7442	4725-4727	IN	denotes	of
T7443	4728-4736	NN	denotes	Trip13Gt
T7444	4737-4739	NN	denotes	Gt
T7445	4736-4737	HYPH	denotes	/
T7446	4740-4753	NNS	denotes	spermatocytes
T7447	4754-4759	MD	denotes	could
T7448	4767-4771	PRP	denotes	them
T7449	4772-4776	IN	denotes	into
T7450	4777-4779	NN	denotes	MI
T7451	4779-4781	,	denotes	,
T7452	4781-4788	IN	denotes	despite
T7453	4789-4790	DT	denotes	a
T7454	4791-4797	NN	denotes	report
T7455	4798-4802	IN	denotes	that
T7456	4820-4825	VB	denotes	occur
T7457	4803-4806	DT	denotes	the
T7458	4807-4811	JJ	denotes	same
T7459	4812-4815	VBD	denotes	did
T7460	4816-4819	RB	denotes	not
T7461	4826-4830	WRB	denotes	when
T7462	4870-4877	VBN	denotes	treated
T7463	4831-4835	JJ	denotes	wild
T7464	4836-4840	NN	denotes	type
T7465	4835-4836	HYPH	denotes	-
T7466	4851-4864	NNS	denotes	spermatocytes
T7467	4841-4850	NN	denotes	pachytene
T7468	4865-4869	VBD	denotes	were
T7469	4878-4882	IN	denotes	with
T7470	4883-4886	DT	denotes	the
T7471	4900-4906	NNS	denotes	agents
T7472	4887-4890	NN	denotes	DSB
T7473	4891-4899	VBG	denotes	inducing
T7474	4890-4891	HYPH	denotes	-
T7475	4907-4912	NN	denotes	gamma
T7476	4913-4922	NN	denotes	radiation
T7477	4923-4925	CC	denotes	or
T7478	4926-4935	NN	denotes	etoposide
T7479	4936-4937	-LRB-	denotes	[
T7480	4937-4939	CD	denotes	53
T7481	4939-4940	-RRB-	denotes	]
T7482	4940-4941	.	denotes	.
T7483	4941-5147	sentence	denotes	It is possible that the nascent induction of DSBs in pachynema evokes a checkpoint response that cannot be bypassed by OA, whereas the post-strand invasion lesions in TRIP13-deficient spermatocytes do not.
T7484	4942-4944	PRP	denotes	It
T7485	4945-4947	VBZ	denotes	is
T7486	4948-4956	JJ	denotes	possible
T7487	4957-4961	IN	denotes	that
T7488	5005-5011	VBZ	denotes	evokes
T7489	4962-4965	DT	denotes	the
T7490	4974-4983	NN	denotes	induction
T7491	4966-4973	JJ	denotes	nascent
T7492	4984-4986	IN	denotes	of
T7493	4987-4991	NNS	denotes	DSBs
T7494	4992-4994	IN	denotes	in
T7495	4995-5004	NN	denotes	pachynema
T7496	5012-5013	DT	denotes	a
T7497	5025-5033	NN	denotes	response
T7498	5014-5024	NN	denotes	checkpoint
T7499	5034-5038	WDT	denotes	that
T7500	5049-5057	VBN	denotes	bypassed
T7501	5039-5042	MD	denotes	can
T7502	5042-5045	RB	denotes	not
T7503	5046-5048	VB	denotes	be
T7504	5058-5060	IN	denotes	by
T7505	5061-5063	NN	denotes	OA
T7506	5063-5065	,	denotes	,
T7507	5065-5072	IN	denotes	whereas
T7508	5140-5142	VBP	denotes	do
T7509	5073-5076	DT	denotes	the
T7510	5098-5105	NNS	denotes	lesions
T7511	5077-5088	JJ	denotes	post-strand
T7512	5089-5097	RB	denotes	invasion
T7513	5106-5108	IN	denotes	in
T7514	5109-5115	NN	denotes	TRIP13
T7515	5116-5125	JJ	denotes	deficient
T7516	5115-5116	HYPH	denotes	-
T7517	5126-5139	NNS	denotes	spermatocytes
T7518	5143-5146	RB	denotes	not
T7519	5146-5147	.	denotes	.
T7520	5147-5313	sentence	denotes	TRIP13 was originally discovered to be an interactor with rat thyroid receptor beta (THRB; [54]), but the relationship between THRB and TRIP13 in meiosis is unknown.
T7521	5148-5154	NN	denotes	TRIP13
T7522	5170-5180	VBN	denotes	discovered
T7523	5155-5158	VBD	denotes	was
T7524	5159-5169	RB	denotes	originally
T7525	5181-5183	TO	denotes	to
T7526	5184-5186	VB	denotes	be
T7527	5187-5189	DT	denotes	an
T7528	5190-5200	NN	denotes	interactor
T7529	5201-5205	IN	denotes	with
T7530	5206-5209	NN	denotes	rat
T7531	5227-5231	NN	denotes	beta
T7532	5210-5217	NN	denotes	thyroid
T7533	5218-5226	NN	denotes	receptor
T7534	5232-5233	-LRB-	denotes	(
T7535	5233-5237	NN	denotes	THRB
T7536	5237-5238	:	denotes	;
T7537	5239-5240	-LRB-	denotes	[
T7538	5240-5242	CD	denotes	54
T7539	5242-5243	-RRB-	denotes	]
T7540	5243-5244	-RRB-	denotes	)
T7541	5244-5246	,	denotes	,
T7542	5246-5249	CC	denotes	but
T7543	5250-5253	DT	denotes	the
T7544	5254-5266	NN	denotes	relationship
T7545	5302-5304	VBZ	denotes	is
T7546	5267-5274	IN	denotes	between
T7547	5275-5279	NN	denotes	THRB
T7548	5280-5283	CC	denotes	and
T7549	5284-5290	NN	denotes	TRIP13
T7550	5291-5293	IN	denotes	in
T7551	5294-5301	NN	denotes	meiosis
T7552	5305-5312	JJ	denotes	unknown
T7553	5312-5313	.	denotes	.
T7554	5313-5658	sentence	denotes	Interestingly, we observed that THRB is distributed diffusely throughout wild-type spermatocyte nuclei but is excluded from the XY (sex) body (unpublished observations), a compartmentalized nuclear domain beginning in pachynema, in which the sex chromosomes become heterochromatinized and transcriptionally silenced in the process of MSCI [55].
T7555	5314-5327	RB	denotes	Interestingly
T7556	5332-5340	VBD	denotes	observed
T7557	5327-5329	,	denotes	,
T7558	5329-5331	PRP	denotes	we
T7559	5341-5345	IN	denotes	that
T7560	5354-5365	VBN	denotes	distributed
T7561	5346-5350	NN	denotes	THRB
T7562	5351-5353	VBZ	denotes	is
T7563	5366-5375	RB	denotes	diffusely
T7564	5376-5386	IN	denotes	throughout
T7565	5387-5391	JJ	denotes	wild
T7566	5392-5396	NN	denotes	type
T7567	5391-5392	HYPH	denotes	-
T7568	5410-5416	NNS	denotes	nuclei
T7569	5397-5409	NN	denotes	spermatocyte
T7570	5417-5420	CC	denotes	but
T7571	5421-5423	VBZ	denotes	is
T7572	5424-5432	VBN	denotes	excluded
T7573	5433-5437	IN	denotes	from
T7574	5438-5441	DT	denotes	the
T7575	5451-5455	NN	denotes	body
T7576	5442-5444	NN	denotes	XY
T7577	5445-5446	-LRB-	denotes	(
T7578	5446-5449	NN	denotes	sex
T7579	5449-5450	-RRB-	denotes	)
T7580	5456-5457	-LRB-	denotes	(
T7581	5469-5481	NNS	denotes	observations
T7582	5457-5468	JJ	denotes	unpublished
T7583	5481-5482	-RRB-	denotes	)
T7584	5482-5484	,	denotes	,
T7585	5484-5485	DT	denotes	a
T7586	5512-5518	NN	denotes	domain
T7587	5486-5503	VBN	denotes	compartmentalized
T7588	5504-5511	JJ	denotes	nuclear
T7589	5519-5528	VBG	denotes	beginning
T7590	5529-5531	IN	denotes	in
T7591	5532-5541	NN	denotes	pachynema
T7592	5541-5543	,	denotes	,
T7593	5543-5545	IN	denotes	in
T7594	5572-5578	VBP	denotes	become
T7595	5546-5551	WDT	denotes	which
T7596	5552-5555	DT	denotes	the
T7597	5560-5571	NNS	denotes	chromosomes
T7598	5556-5559	NN	denotes	sex
T7599	5579-5598	VBN	denotes	heterochromatinized
T7600	5599-5602	CC	denotes	and
T7601	5603-5620	RB	denotes	transcriptionally
T7602	5621-5629	VBN	denotes	silenced
T7603	5630-5632	IN	denotes	in
T7604	5633-5636	DT	denotes	the
T7605	5637-5644	NN	denotes	process
T7606	5645-5647	IN	denotes	of
T7607	5648-5652	NN	denotes	MSCI
T7608	5653-5654	-LRB-	denotes	[
T7609	5654-5656	CD	denotes	55
T7610	5656-5657	-RRB-	denotes	]
T7611	5657-5658	.	denotes	.
T7612	5658-5815	sentence	denotes	However, the XY body appeared intact in most mutant spermatocytes upon probing with several markers of XY heterochromatinization (unpublished observations).
T7613	5659-5666	RB	denotes	However
T7614	5680-5688	VBD	denotes	appeared
T7615	5666-5668	,	denotes	,
T7616	5668-5671	DT	denotes	the
T7617	5675-5679	NN	denotes	body
T7618	5672-5674	NN	denotes	XY
T7619	5689-5695	JJ	denotes	intact
T7620	5696-5698	IN	denotes	in
T7621	5699-5703	JJS	denotes	most
T7622	5711-5724	NNS	denotes	spermatocytes
T7623	5704-5710	NN	denotes	mutant
T7624	5725-5729	IN	denotes	upon
T7625	5730-5737	VBG	denotes	probing
T7626	5738-5742	IN	denotes	with
T7627	5743-5750	JJ	denotes	several
T7628	5751-5758	NNS	denotes	markers
T7629	5759-5761	IN	denotes	of
T7630	5762-5764	NN	denotes	XY
T7631	5765-5787	NN	denotes	heterochromatinization
T7632	5788-5789	-LRB-	denotes	(
T7633	5801-5813	NNS	denotes	observations
T7634	5789-5800	JJ	denotes	unpublished
T7635	5813-5814	-RRB-	denotes	)
T7636	5814-5815	.	denotes	.
T7637	5815-5968	sentence	denotes	Considering that THRB knockout mice are viable and fertile [56], the functional relationship between TRIP13 and its receptor THRB in meiosis is unclear.
T7638	5816-5827	VBG	denotes	Considering
T7639	5957-5959	VBZ	denotes	is
T7640	5828-5832	IN	denotes	that
T7641	5852-5855	VBP	denotes	are
T7642	5833-5837	NN	denotes	THRB
T7643	5838-5846	NN	denotes	knockout
T7644	5847-5851	NNS	denotes	mice
T7645	5856-5862	JJ	denotes	viable
T7646	5863-5866	CC	denotes	and
T7647	5867-5874	JJ	denotes	fertile
T7648	5875-5876	-LRB-	denotes	[
T7649	5876-5878	CD	denotes	56
T7650	5878-5879	-RRB-	denotes	]
T7651	5879-5881	,	denotes	,
T7652	5881-5884	DT	denotes	the
T7653	5896-5908	NN	denotes	relationship
T7654	5885-5895	JJ	denotes	functional
T7655	5909-5916	IN	denotes	between
T7656	5917-5923	NN	denotes	TRIP13
T7657	5924-5927	CC	denotes	and
T7658	5928-5931	PRP$	denotes	its
T7659	5932-5940	NN	denotes	receptor
T7660	5941-5945	NN	denotes	THRB
T7661	5946-5948	IN	denotes	in
T7662	5949-5956	NN	denotes	meiosis
T7663	5960-5967	JJ	denotes	unclear
T7664	5967-5968	.	denotes	.
T7665	5968-6112	sentence	denotes	Given the high similarity of PCH2 orthologs throughout the eukaryotic world, one or more essential functions of this protein must be conserved.
T7666	5969-5974	VBN	denotes	Given
T7667	6102-6111	VBN	denotes	conserved
T7668	5975-5978	DT	denotes	the
T7669	5984-5994	NN	denotes	similarity
T7670	5979-5983	JJ	denotes	high
T7671	5995-5997	IN	denotes	of
T7672	5998-6002	NN	denotes	PCH2
T7673	6003-6012	NNS	denotes	orthologs
T7674	6013-6023	IN	denotes	throughout
T7675	6024-6027	DT	denotes	the
T7676	6039-6044	NN	denotes	world
T7677	6028-6038	JJ	denotes	eukaryotic
T7678	6044-6046	,	denotes	,
T7679	6046-6049	CD	denotes	one
T7680	6068-6077	NNS	denotes	functions
T7681	6050-6052	CC	denotes	or
T7682	6053-6057	JJR	denotes	more
T7683	6058-6067	JJ	denotes	essential
T7684	6078-6080	IN	denotes	of
T7685	6081-6085	DT	denotes	this
T7686	6086-6093	NN	denotes	protein
T7687	6094-6098	MD	denotes	must
T7688	6099-6101	VB	denotes	be
T7689	6111-6112	.	denotes	.
T7690	6112-6283	sentence	denotes	Since TRIP13 does not exhibit checkpoint function in mice, we surmise that the TRIP13/PCH2 ancestral protein had a function in recombination that persists to the present.
T7691	6113-6118	IN	denotes	Since
T7692	6135-6142	VB	denotes	exhibit
T7693	6119-6125	NN	denotes	TRIP13
T7694	6126-6130	VBZ	denotes	does
T7695	6131-6134	RB	denotes	not
T7696	6175-6182	VBP	denotes	surmise
T7697	6143-6153	NN	denotes	checkpoint
T7698	6154-6162	NN	denotes	function
T7699	6163-6165	IN	denotes	in
T7700	6166-6170	NNS	denotes	mice
T7701	6170-6172	,	denotes	,
T7702	6172-6174	PRP	denotes	we
T7703	6183-6187	IN	denotes	that
T7704	6222-6225	VBD	denotes	had
T7705	6188-6191	DT	denotes	the
T7706	6214-6221	NN	denotes	protein
T7707	6192-6198	NN	denotes	TRIP13
T7708	6199-6203	NN	denotes	PCH2
T7709	6198-6199	HYPH	denotes	/
T7710	6204-6213	JJ	denotes	ancestral
T7711	6226-6227	DT	denotes	a
T7712	6228-6236	NN	denotes	function
T7713	6237-6239	IN	denotes	in
T7714	6240-6253	NN	denotes	recombination
T7715	6254-6258	WDT	denotes	that
T7716	6259-6267	VBZ	denotes	persists
T7717	6268-6270	IN	denotes	to
T7718	6271-6274	DT	denotes	the
T7719	6275-6282	JJ	denotes	present
T7720	6282-6283	.	denotes	.
T7721	6283-6594	sentence	denotes	Notably, A. thaliana does not appear to have a meiotic checkpoint activity that eliminates mutant meiocytes in a manner analogous to organisms such as mice, budding yeast, and female Drosophila [11,57], and mammalian TRIP13 is more similar to Arabidopsis PCH2 than the fly or worm proteins (Figures 1A and S1).
T7722	6284-6291	RB	denotes	Notably
T7723	6314-6320	VB	denotes	appear
T7724	6291-6293	,	denotes	,
T7725	6293-6295	NNP	denotes	A.
T7726	6296-6304	NNP	denotes	thaliana
T7727	6305-6309	VBZ	denotes	does
T7728	6310-6313	RB	denotes	not
T7729	6321-6323	TO	denotes	to
T7730	6324-6328	VB	denotes	have
T7731	6329-6330	DT	denotes	a
T7732	6350-6358	NN	denotes	activity
T7733	6331-6338	JJ	denotes	meiotic
T7734	6339-6349	NN	denotes	checkpoint
T7735	6359-6363	WDT	denotes	that
T7736	6364-6374	VBZ	denotes	eliminates
T7737	6375-6381	NN	denotes	mutant
T7738	6382-6391	NNS	denotes	meiocytes
T7739	6392-6394	IN	denotes	in
T7740	6395-6396	DT	denotes	a
T7741	6397-6403	NN	denotes	manner
T7742	6404-6413	JJ	denotes	analogous
T7743	6414-6416	IN	denotes	to
T7744	6417-6426	NNS	denotes	organisms
T7745	6427-6431	JJ	denotes	such
T7746	6432-6434	IN	denotes	as
T7747	6435-6439	NNS	denotes	mice
T7748	6439-6441	,	denotes	,
T7749	6441-6448	VBG	denotes	budding
T7750	6449-6454	NN	denotes	yeast
T7751	6454-6456	,	denotes	,
T7752	6456-6459	CC	denotes	and
T7753	6460-6466	JJ	denotes	female
T7754	6467-6477	NNP	denotes	Drosophila
T7755	6478-6479	-LRB-	denotes	[
T7756	6482-6484	CD	denotes	57
T7757	6479-6481	CD	denotes	11
T7758	6481-6482	,	denotes	,
T7759	6484-6485	-RRB-	denotes	]
T7760	6485-6487	,	denotes	,
T7761	6487-6490	CC	denotes	and
T7762	6491-6500	JJ	denotes	mammalian
T7763	6501-6507	NN	denotes	TRIP13
T7764	6508-6510	VBZ	denotes	is
T7765	6511-6515	RBR	denotes	more
T7766	6516-6523	JJ	denotes	similar
T7767	6524-6526	IN	denotes	to
T7768	6527-6538	NNP	denotes	Arabidopsis
T7769	6539-6543	NN	denotes	PCH2
T7770	6544-6548	IN	denotes	than
T7771	6549-6552	DT	denotes	the
T7772	6565-6573	NN	denotes	proteins
T7773	6553-6556	NN	denotes	fly
T7774	6557-6559	CC	denotes	or
T7775	6560-6564	NN	denotes	worm
T7776	6574-6575	-LRB-	denotes	(
T7777	6583-6585	NN	denotes	1A
T7778	6575-6582	NNS	denotes	Figures
T7779	6586-6589	CC	denotes	and
T7780	6590-6592	NN	denotes	S1
T7781	6592-6593	-RRB-	denotes	)
T7782	6593-6594	.	denotes	.
T7783	6594-6859	sentence	denotes	The unusual relatedness between mammalian and plant PCH2 may therefore be attributable to both the presence of a common conserved function (namely recombination, although the role of PCH2 in plants has yet to be determined), and the absence of checkpoint function.
T7784	6595-6598	DT	denotes	The
T7785	6607-6618	NN	denotes	relatedness
T7786	6599-6606	JJ	denotes	unusual
T7787	6666-6668	VB	denotes	be
T7788	6619-6626	IN	denotes	between
T7789	6627-6636	JJ	denotes	mammalian
T7790	6647-6651	NN	denotes	PCH2
T7791	6637-6640	CC	denotes	and
T7792	6641-6646	NN	denotes	plant
T7793	6652-6655	MD	denotes	may
T7794	6656-6665	RB	denotes	therefore
T7795	6669-6681	JJ	denotes	attributable
T7796	6682-6684	IN	denotes	to
T7797	6685-6689	CC	denotes	both
T7798	6694-6702	NN	denotes	presence
T7799	6690-6693	DT	denotes	the
T7800	6703-6705	IN	denotes	of
T7801	6706-6707	DT	denotes	a
T7802	6725-6733	NN	denotes	function
T7803	6708-6714	JJ	denotes	common
T7804	6715-6724	VBN	denotes	conserved
T7805	6734-6735	-LRB-	denotes	(
T7806	6742-6755	NN	denotes	recombination
T7807	6735-6741	RB	denotes	namely
T7808	6755-6757	,	denotes	,
T7809	6757-6765	IN	denotes	although
T7810	6793-6796	VBZ	denotes	has
T7811	6766-6769	DT	denotes	the
T7812	6770-6774	NN	denotes	role
T7813	6775-6777	IN	denotes	of
T7814	6778-6782	NN	denotes	PCH2
T7815	6783-6785	IN	denotes	in
T7816	6786-6792	NNS	denotes	plants
T7817	6797-6800	RB	denotes	yet
T7818	6807-6817	VBN	denotes	determined
T7819	6801-6803	TO	denotes	to
T7820	6804-6806	VB	denotes	be
T7821	6817-6818	-RRB-	denotes	)
T7822	6818-6820	,	denotes	,
T7823	6820-6823	CC	denotes	and
T7824	6824-6827	DT	denotes	the
T7825	6828-6835	NN	denotes	absence
T7826	6836-6838	IN	denotes	of
T7827	6839-6849	NN	denotes	checkpoint
T7828	6850-6858	NN	denotes	function
T7829	6858-6859	.	denotes	.
T7830	6859-7109	sentence	denotes	Nevertheless, the evolutionary relationships between animals, fungi, and plants (which are discordant with PCH2 sequence phylogeny) do not allow parsimonious models addressing the points in time that checkpoint functions in PCH2 were gained or lost.
T7831	6860-6872	RB	denotes	Nevertheless
T7832	6999-7004	VB	denotes	allow
T7833	6872-6874	,	denotes	,
T7834	6874-6877	DT	denotes	the
T7835	6891-6904	NNS	denotes	relationships
T7836	6878-6890	JJ	denotes	evolutionary
T7837	6905-6912	IN	denotes	between
T7838	6913-6920	NNS	denotes	animals
T7839	6920-6922	,	denotes	,
T7840	6922-6927	NNS	denotes	fungi
T7841	6927-6929	,	denotes	,
T7842	6929-6932	CC	denotes	and
T7843	6933-6939	NNS	denotes	plants
T7844	6940-6941	-LRB-	denotes	(
T7845	6941-6946	WDT	denotes	which
T7846	6947-6950	VBP	denotes	are
T7847	6951-6961	JJ	denotes	discordant
T7848	6962-6966	IN	denotes	with
T7849	6967-6971	NN	denotes	PCH2
T7850	6981-6990	NN	denotes	phylogeny
T7851	6972-6980	NN	denotes	sequence
T7852	6990-6991	-RRB-	denotes	)
T7853	6992-6994	VBP	denotes	do
T7854	6995-6998	RB	denotes	not
T7855	7005-7017	JJ	denotes	parsimonious
T7856	7018-7024	NNS	denotes	models
T7857	7025-7035	VBG	denotes	addressing
T7858	7036-7039	DT	denotes	the
T7859	7040-7046	NNS	denotes	points
T7860	7047-7049	IN	denotes	in
T7861	7050-7054	NN	denotes	time
T7862	7055-7059	IN	denotes	that
T7863	7094-7100	VBN	denotes	gained
T7864	7060-7070	NN	denotes	checkpoint
T7865	7071-7080	NNS	denotes	functions
T7866	7081-7083	IN	denotes	in
T7867	7084-7088	NN	denotes	PCH2
T7868	7089-7093	VBD	denotes	were
T7869	7101-7103	CC	denotes	or
T7870	7104-7108	VBN	denotes	lost
T7871	7108-7109	.	denotes	.
T7872	7109-7203	sentence	denotes	It is possible that its checkpoint function evolved independently in worms and budding yeast.
T7873	7110-7112	PRP	denotes	It
T7874	7113-7115	VBZ	denotes	is
T7875	7116-7124	JJ	denotes	possible
T7876	7125-7129	IN	denotes	that
T7877	7154-7161	VBD	denotes	evolved
T7878	7130-7133	PRP$	denotes	its
T7879	7145-7153	NN	denotes	function
T7880	7134-7144	NN	denotes	checkpoint
T7881	7162-7175	RB	denotes	independently
T7882	7176-7178	IN	denotes	in
T7883	7179-7184	NNS	denotes	worms
T7884	7185-7188	CC	denotes	and
T7885	7189-7196	NN	denotes	budding
T7886	7197-7202	NN	denotes	yeast
T7887	7202-7203	.	denotes	.
T7888	7203-7293	sentence	denotes	The picture will become clearer as the function of PCH2 in other organisms is elucidated.
T7889	7204-7207	DT	denotes	The
T7890	7208-7215	NN	denotes	picture
T7891	7221-7227	VB	denotes	become
T7892	7216-7220	MD	denotes	will
T7893	7228-7235	JJR	denotes	clearer
T7894	7236-7238	IN	denotes	as
T7895	7282-7292	VBN	denotes	elucidated
T7896	7239-7242	DT	denotes	the
T7897	7243-7251	NN	denotes	function
T7898	7252-7254	IN	denotes	of
T7899	7255-7259	NN	denotes	PCH2
T7900	7260-7262	IN	denotes	in
T7901	7263-7268	JJ	denotes	other
T7902	7269-7278	NNS	denotes	organisms
T7903	7279-7281	VBZ	denotes	is
T7904	7292-7293	.	denotes	.
T7905	7293-7366	sentence	denotes	The nature of the synapsis checkpoint in male mice remains unidentified.
T7906	7294-7297	DT	denotes	The
T7907	7298-7304	NN	denotes	nature
T7908	7345-7352	VBZ	denotes	remains
T7909	7305-7307	IN	denotes	of
T7910	7308-7311	DT	denotes	the
T7911	7321-7331	NN	denotes	checkpoint
T7912	7312-7320	NN	denotes	synapsis
T7913	7332-7334	IN	denotes	in
T7914	7335-7339	JJ	denotes	male
T7915	7340-7344	NNS	denotes	mice
T7916	7353-7365	JJ	denotes	unidentified
T7917	7365-7366	.	denotes	.
T7918	7366-7625	sentence	denotes	One possible candidate is Dot1 (PCH1 in yeast), a histone methyltransferase silencing factor that is required for pachytene arrest of zip1 and dmc1 mutants in yeast [58], and for preventing RAD54-mediated recombinational DSB repair between sister chromatids.
T7919	7367-7370	CD	denotes	One
T7920	7380-7389	NN	denotes	candidate
T7921	7371-7379	JJ	denotes	possible
T7922	7390-7392	VBZ	denotes	is
T7923	7393-7397	NN	denotes	Dot1
T7924	7398-7399	-LRB-	denotes	(
T7925	7399-7403	NN	denotes	PCH1
T7926	7404-7406	IN	denotes	in
T7927	7407-7412	NN	denotes	yeast
T7928	7412-7413	-RRB-	denotes	)
T7929	7413-7415	,	denotes	,
T7930	7415-7416	DT	denotes	a
T7931	7453-7459	NN	denotes	factor
T7932	7417-7424	NN	denotes	histone
T7933	7425-7442	NN	denotes	methyltransferase
T7934	7443-7452	NN	denotes	silencing
T7935	7460-7464	WDT	denotes	that
T7936	7468-7476	VBN	denotes	required
T7937	7465-7467	VBZ	denotes	is
T7938	7477-7480	IN	denotes	for
T7939	7481-7490	NN	denotes	pachytene
T7940	7491-7497	NN	denotes	arrest
T7941	7498-7500	IN	denotes	of
T7942	7501-7505	NN	denotes	zip1
T7943	7515-7522	NNS	denotes	mutants
T7944	7506-7509	CC	denotes	and
T7945	7510-7514	NN	denotes	dmc1
T7946	7523-7525	IN	denotes	in
T7947	7526-7531	NN	denotes	yeast
T7948	7532-7533	-LRB-	denotes	[
T7949	7533-7535	CD	denotes	58
T7950	7535-7536	-RRB-	denotes	]
T7951	7536-7538	,	denotes	,
T7952	7538-7541	CC	denotes	and
T7953	7542-7545	IN	denotes	for
T7954	7546-7556	VBG	denotes	preventing
T7955	7557-7562	NN	denotes	RAD54
T7956	7563-7571	VBN	denotes	mediated
T7957	7562-7563	HYPH	denotes	-
T7958	7592-7598	NN	denotes	repair
T7959	7572-7587	JJ	denotes	recombinational
T7960	7588-7591	NN	denotes	DSB
T7961	7599-7606	IN	denotes	between
T7962	7607-7613	NN	denotes	sister
T7963	7614-7624	NNS	denotes	chromatids
T7964	7624-7625	.	denotes	.
T7965	7625-7662	sentence	denotes	However, DOT1 acts upstream of PCH2.
T7966	7626-7633	RB	denotes	However
T7967	7640-7644	VBZ	denotes	acts
T7968	7633-7635	,	denotes	,
T7969	7635-7639	NN	denotes	DOT1
T7970	7645-7653	RB	denotes	upstream
T7971	7654-7656	IN	denotes	of
T7972	7657-7661	NN	denotes	PCH2
T7973	7661-7662	.	denotes	.
T7974	7662-7823	sentence	denotes	Given that TRIP13 doesn't have checkpoint function in mice, a potential role for mammalian DOT1 in the pachytene checkpoint is dubious but awaits investigation.
T7975	7663-7668	VBN	denotes	Given
T7976	7787-7789	VBZ	denotes	is
T7977	7669-7673	IN	denotes	that
T7978	7689-7693	VB	denotes	have
T7979	7674-7680	NN	denotes	TRIP13
T7980	7681-7685	VBZ	denotes	does
T7981	7685-7688	RB	denotes	n't
T7982	7694-7704	NN	denotes	checkpoint
T7983	7705-7713	NN	denotes	function
T7984	7714-7716	IN	denotes	in
T7985	7717-7721	NNS	denotes	mice
T7986	7721-7723	,	denotes	,
T7987	7723-7724	DT	denotes	a
T7988	7735-7739	NN	denotes	role
T7989	7725-7734	JJ	denotes	potential
T7990	7740-7743	IN	denotes	for
T7991	7744-7753	JJ	denotes	mammalian
T7992	7754-7758	NN	denotes	DOT1
T7993	7759-7761	IN	denotes	in
T7994	7762-7765	DT	denotes	the
T7995	7776-7786	NN	denotes	checkpoint
T7996	7766-7775	NN	denotes	pachytene
T7997	7790-7797	JJ	denotes	dubious
T7998	7798-7801	CC	denotes	but
T7999	7802-7808	VBZ	denotes	awaits
T8000	7809-7822	NN	denotes	investigation
T8001	7822-7823	.	denotes	.
T8002	7823-8037	sentence	denotes	Recently, it was shown that the TRP53 homolog TRP63 is required for DNA damage–induced death of dictyate-stage primordial oocytes, leading to the suggestion that it is involved in monitoring genome integrity [59].
T8003	7824-7832	RB	denotes	Recently
T8004	7841-7846	VBN	denotes	shown
T8005	7832-7834	,	denotes	,
T8006	7834-7836	PRP	denotes	it
T8007	7837-7840	VBD	denotes	was
T8008	7847-7851	IN	denotes	that
T8009	7879-7887	VBN	denotes	required
T8010	7852-7855	DT	denotes	the
T8011	7862-7869	NN	denotes	homolog
T8012	7856-7861	NN	denotes	TRP53
T8013	7870-7875	NN	denotes	TRP63
T8014	7876-7878	VBZ	denotes	is
T8015	7888-7891	IN	denotes	for
T8016	7892-7895	NN	denotes	DNA
T8017	7896-7902	NN	denotes	damage
T8018	7903-7910	VBN	denotes	induced
T8019	7902-7903	HYPH	denotes	–
T8020	7911-7916	NN	denotes	death
T8021	7917-7919	IN	denotes	of
T8022	7920-7928	NN	denotes	dictyate
T8023	7929-7934	NN	denotes	stage
T8024	7928-7929	HYPH	denotes	-
T8025	7946-7953	NNS	denotes	oocytes
T8026	7935-7945	JJ	denotes	primordial
T8027	7953-7955	,	denotes	,
T8028	7955-7962	VBG	denotes	leading
T8029	7963-7965	IN	denotes	to
T8030	7966-7969	DT	denotes	the
T8031	7970-7980	NN	denotes	suggestion
T8032	7981-7985	IN	denotes	that
T8033	7992-8000	VBN	denotes	involved
T8034	7986-7988	PRP	denotes	it
T8035	7989-7991	VBZ	denotes	is
T8036	8001-8003	IN	denotes	in
T8037	8004-8014	VBG	denotes	monitoring
T8038	8015-8021	NN	denotes	genome
T8039	8022-8031	NN	denotes	integrity
T8040	8032-8033	-LRB-	denotes	[
T8041	8033-8035	CD	denotes	59
T8042	8035-8036	-RRB-	denotes	]
T8043	8036-8037	.	denotes	.
T8044	8037-8105	sentence	denotes	However, this activity occurs subsequent to a pachytene checkpoint.
T8045	8038-8045	RB	denotes	However
T8046	8061-8067	VBZ	denotes	occurs
T8047	8045-8047	,	denotes	,
T8048	8047-8051	DT	denotes	this
T8049	8052-8060	NN	denotes	activity
T8050	8068-8078	RB	denotes	subsequent
T8051	8079-8081	IN	denotes	to
T8052	8082-8083	DT	denotes	a
T8053	8094-8104	NN	denotes	checkpoint
T8054	8084-8093	NN	denotes	pachytene
T8055	8104-8105	.	denotes	.
T8056	8105-8334	sentence	denotes	As alluded to earlier, a complicating problem for studying potential meiotic checkpoint genes in mice is that as in yeast, such genes often have mitotic functions (such as RAD24 [7]), and their ablation can cause lethality [42].
T8057	8106-8108	IN	denotes	As
T8058	8109-8116	VBN	denotes	alluded
T8059	8208-8210	VBZ	denotes	is
T8060	8117-8119	IN	denotes	to
T8061	8120-8127	RBR	denotes	earlier
T8062	8127-8129	,	denotes	,
T8063	8129-8130	DT	denotes	a
T8064	8144-8151	NN	denotes	problem
T8065	8131-8143	VBG	denotes	complicating
T8066	8152-8155	IN	denotes	for
T8067	8156-8164	VBG	denotes	studying
T8068	8165-8174	JJ	denotes	potential
T8069	8183-8193	NN	denotes	checkpoint
T8070	8175-8182	JJ	denotes	meiotic
T8071	8194-8199	NNS	denotes	genes
T8072	8200-8202	IN	denotes	in
T8073	8203-8207	NNS	denotes	mice
T8074	8211-8215	IN	denotes	that
T8075	8246-8250	VBP	denotes	have
T8076	8216-8218	IN	denotes	as
T8115	8412-8421	NNS	denotes	functions
T8116	8422-8424	IN	denotes	in
T8117	8425-8434	NNS	denotes	organisms
T8118	8435-8439	JJ	denotes	such
T8119	8440-8442	IN	denotes	as
T8120	8443-8448	NN	denotes	yeast
T8121	8448-8450	,	denotes	,
T8122	8450-8455	PRP$	denotes	their
T8123	8456-8466	NNS	denotes	identities
T8124	8471-8477	JJ	denotes	likely
T8125	8478-8480	TO	denotes	to
T8126	8481-8487	VB	denotes	remain
T8127	8488-8495	JJ	denotes	elusive
T8128	8495-8496	.	denotes	.
T8077	8219-8221	IN	denotes	in
T8078	8222-8227	NN	denotes	yeast
T8079	8227-8229	,	denotes	,
T8080	8229-8233	JJ	denotes	such
T8081	8234-8239	NNS	denotes	genes
T8082	8240-8245	RB	denotes	often
T8083	8251-8258	JJ	denotes	mitotic
T8084	8259-8268	NNS	denotes	functions
T8085	8269-8270	-LRB-	denotes	(
T8086	8270-8274	JJ	denotes	such
T8087	8275-8277	IN	denotes	as
T8088	8278-8283	NN	denotes	RAD24
T8089	8284-8285	-LRB-	denotes	[
T8090	8285-8286	CD	denotes	7
T8091	8286-8287	-RRB-	denotes	]
T8092	8287-8288	-RRB-	denotes	)
T8093	8288-8290	,	denotes	,
T8094	8290-8293	CC	denotes	and
T8095	8294-8299	PRP$	denotes	their
T8096	8300-8308	NN	denotes	ablation
T8097	8313-8318	VB	denotes	cause
T8098	8309-8312	MD	denotes	can
T8099	8319-8328	NN	denotes	lethality
T8100	8329-8330	-LRB-	denotes	[
T8101	8330-8332	CD	denotes	42
T8102	8332-8333	-RRB-	denotes	]
T8103	8333-8334	.	denotes	.
T8104	8334-8496	sentence	denotes	Unless mammalian pachytene checkpoint components have orthologs with similar functions in organisms such as yeast, their identities are likely to remain elusive.
T8105	8335-8341	IN	denotes	Unless
T8106	8384-8388	VBP	denotes	have
T8107	8342-8351	JJ	denotes	mammalian
T8108	8373-8383	NNS	denotes	components
T8109	8352-8361	NN	denotes	pachytene
T8110	8362-8372	NN	denotes	checkpoint
T8111	8467-8470	VBP	denotes	are
T8112	8389-8398	NNS	denotes	orthologs
T8113	8399-8403	IN	denotes	with
T8114	8404-8411	JJ	denotes	similar
R4005	T6565	T6566	amod	Genetic,experiments
R4006	T6566	T6567	nsubj	experiments,provided
R4007	T6568	T6566	prep	in,experiments
R4008	T6569	T6570	compound	S.,cerevisiae
R4009	T6570	T6568	pobj	cerevisiae,in
R4010	T6571	T6567	dobj	evidence,provided
R4011	T6572	T6573	mark	that,monitors
R4012	T6573	T6571	acl	monitors,evidence
R4013	T6574	T6575	det	the,checkpoint
R4014	T6575	T6573	nsubj	checkpoint,monitors
R4015	T6576	T6575	compound	pachytene,checkpoint
R4016	T6577	T6573	cc	and,monitors
R4017	T6578	T6573	conj	responds,monitors
R4018	T6579	T6578	prep	to,responds
R4019	T6580	T6581	amod	recombinational,repair
R4020	T6581	T6573	dobj	repair,monitors
R4021	T6582	T6581	compound	DSB,repair
R4022	T6583	T6581	cc	and,repair
R4023	T6584	T6581	conj	synapsis,repair
R4024	T6585	T6573	advmod	independently,monitors
R4025	T6586	T6567	punct	.,provided
R4026	T6588	T6589	nsubj	Wu,concluded
R4027	T6590	T6588	cc	and,Wu
R4028	T6591	T6588	conj	Burgess,Wu
R4029	T6592	T6593	mark	that,is
R4030	T6593	T6589	ccomp	is,concluded
R4031	T6594	T6595	det	the,checkpoint
R4032	T6595	T6593	nsubj	checkpoint,is
R4033	T6596	T6595	compound	repair,checkpoint
R4034	T6597	T6598	compound	RAD17,SAE2
R4035	T6598	T6600	npadvmod	SAE2,dependent
R4036	T6599	T6598	punct	-,SAE2
R4037	T6600	T6593	acomp	dependent,is
R4038	T6601	T6593	punct	", ",is
R4039	T6602	T6603	mark	while,is
R4040	T6603	T6593	advcl	is,is
R4041	T6604	T6605	det	the,checkpoint
R4042	T6605	T6603	nsubj	checkpoint,is
R4043	T6606	T6605	compound	synapsis,checkpoint
R4044	T6607	T6608	compound	PCH2,ZIP1
R4045	T6608	T6610	npadvmod	ZIP1,dependent
R4046	T6609	T6608	punct	-,ZIP1
R4047	T6610	T6603	acomp	dependent,is
R4048	T6611	T6612	punct	[,12
R4049	T6612	T6589	parataxis	12,concluded
R4050	T6613	T6612	punct	],12
R4051	T6614	T6589	punct	.,concluded
R4052	T6616	T6617	prep	Of,have
R4053	T6618	T6619	det	these,genes
R4054	T6619	T6616	pobj	genes,Of
R4055	T6620	T6619	nummod	four,genes
R4056	T6621	T6617	punct	", ",have
R4057	T6622	T6617	nsubj	SAE2,have
R4058	T6623	T6622	cc	and,SAE2
R4059	T6624	T6622	conj	ZIP1,SAE2
R4060	T6625	T6617	aux	do,have
R4061	T6626	T6617	neg	not,have
R4062	T6627	T6628	amod	clear,orthologs
R4063	T6628	T6617	dobj	orthologs,have
R4064	T6629	T6628	amod	mammalian,orthologs
R4065	T6630	T6617	punct	(,have
R4066	T6631	T6632	mark	although,be
R4067	T6632	T6617	advcl	be,have
R4068	T6633	T6632	nsubj	SYCP1,be
R4069	T6634	T6632	aux	may,be
R4070	T6635	T6636	det	a,ortholog
R4071	T6636	T6632	attr	ortholog,be
R4072	T6637	T6636	amod	functional,ortholog
R4073	T6638	T6636	prep	of,ortholog
R4074	T6639	T6638	pobj	ZIP1,of
R4075	T6640	T6617	punct	),have
R4076	T6641	T6617	punct	", ",have
R4077	T6642	T6617	cc	and,have
R4078	T6643	T6644	nsubj	mutation,causes
R4079	T6644	T6617	conj	causes,have
R4080	T6645	T6643	prep	of,mutation
R4081	T6646	T6647	det	the,ortholog
R4082	T6647	T6645	pobj	ortholog,of
R4083	T6648	T6649	compound	mouse,RAD17
R4084	T6649	T6647	compound	RAD17,ortholog
R4085	T6650	T6647	punct	", ",ortholog
R4086	T6651	T6647	appos	Rad1,ortholog
R4087	T6652	T6644	punct	", ",causes
R4088	T6653	T6644	advmod	presumably,causes
R4089	T6654	T6655	amod	embryonic,lethality
R4090	T6655	T6644	dobj	lethality,causes
R4091	T6656	T6657	punct	[,42
R4092	T6657	T6644	parataxis	42,causes
R4093	T6658	T6657	punct	],42
R4094	T6659	T6644	punct	.,causes
R4095	T6661	T6662	advmod	Thus,was
R4096	T6663	T6662	punct	", ",was
R4097	T6664	T6665	amod	mutational,analysis
R4098	T6665	T6662	nsubj	analysis,was
R4099	T6666	T6665	prep	of,analysis
R4100	T6667	T6668	compound	mouse,Pch2
R4101	T6668	T6666	pobj	Pch2,of
R4102	T6669	T6668	punct	(,Pch2
R4103	T6670	T6668	appos	Trip13,Pch2
R4104	T6671	T6665	punct	),analysis
R4105	T6672	T6665	punct	", ",analysis
R4106	T6673	T6674	dep	which,is
R4107	T6674	T6665	relcl	is,analysis
R4108	T6675	T6674	advmod	also,is
R4109	T6676	T6674	acomp	critical,is
R4110	T6677	T6676	prep	for,critical
R4111	T6678	T6679	det	the,checkpoint
R4112	T6679	T6677	pobj	checkpoint,for
R4113	T6680	T6679	compound	synapsis,checkpoint
R4114	T6681	T6674	prep	in,is
R4115	T6682	T6683	compound	C.,elegans
R4116	T6683	T6681	pobj	elegans,in
R4117	T6684	T6685	punct	[,2
R4118	T6685	T6674	parataxis	2,is
R4119	T6686	T6685	punct	],2
R4120	T6687	T6662	punct	", ",was
R4121	T6688	T6689	det	the,option
R4122	T6689	T6662	attr	option,was
R4123	T6690	T6689	amod	best,option
R4124	T6691	T6689	amod	remaining,option
R4125	T6692	T6693	aux	to,evaluate
R4126	T6693	T6662	advcl	evaluate,was
R4127	T6694	T6695	amod	potential,conservation
R4128	T6695	T6693	dobj	conservation,evaluate
R4129	T6696	T6695	amod	functional,conservation
R4130	T6697	T6695	prep	in,conservation
R4131	T6698	T6699	amod	mammalian,control
R4132	T6699	T6697	pobj	control,in
R4133	T6700	T6701	amod	meiotic,checkpoint
R4134	T6701	T6699	compound	checkpoint,control
R4135	T6702	T6662	punct	.,was
R4136	T6704	T6705	poss	Our,results
R4137	T6705	T6706	nsubj	results,demonstrate
R4138	T6707	T6708	mark	that,is
R4139	T6708	T6706	ccomp	is,demonstrate
R4140	T6709	T6708	prep	in,is
R4141	T6710	T6709	pobj	mice,in
R4142	T6711	T6708	punct	", ",is
R4143	T6712	T6713	det	the,function
R4144	T6713	T6708	nsubj	function,is
R4145	T6714	T6713	amod	primary,function
R4146	T6715	T6713	amod	meiotic,function
R4147	T6716	T6713	prep	of,function
R4148	T6717	T6716	pobj	TRIP13,of
R4149	T6718	T6708	prep	in,is
R4150	T6719	T6718	pobj	recombination,in
R4151	T6720	T6719	appos	itself,recombination
R4152	T6721	T6706	punct	.,demonstrate
R4153	T6723	T6724	nsubj	We,found
R4154	T6725	T6726	det	no,evidence
R4155	T6726	T6724	dobj	evidence,found
R4156	T6727	T6728	mark	that,involved
R4157	T6728	T6726	acl	involved,evidence
R4158	T6729	T6728	nsubjpass	it,involved
R4159	T6730	T6728	auxpass	is,involved
R4160	T6731	T6728	prep	in,involved
R4161	T6732	T6733	compound	pachytene,checkpoint
R4162	T6733	T6734	compound	checkpoint,control
R4163	T6734	T6731	pobj	control,in
R4164	T6735	T6724	punct	.,found
R4165	T6737	T6738	poss	Our,data
R4166	T6738	T6739	nsubj	data,suggest
R4167	T6740	T6741	mark	that,resolved
R4168	T6741	T6739	ccomp	resolved,suggest
R4169	T6742	T6743	mark	while,proceed
R4170	T6743	T6741	advcl	proceed,resolved
R4171	T6744	T6745	compound	recombination,events
R4172	T6745	T6743	nsubj	events,proceed
R4173	T6746	T6745	acl	destined,events
R4174	T6747	T6748	aux	to,resolved
R4175	T6748	T6746	xcomp	resolved,destined
R4176	T6749	T6748	auxpass	be,resolved
R4177	T6750	T6748	prep	as,resolved
R4178	T6751	T6750	pobj	COs,as
R4179	T6752	T6743	aux	can,proceed
R4180	T6753	T6743	advmod	normally,proceed
R4181	T6754	T6743	prep	in,proceed
R4182	T6755	T6756	compound	Trip13,mutants
R4183	T6756	T6754	pobj	mutants,in
R4184	T6757	T6741	punct	", ",resolved
R4185	T6758	T6741	nsubjpass	DSBs,resolved
R4186	T6759	T6760	dep	that,enter
R4187	T6760	T6758	relcl	enter,DSBs
R4188	T6761	T6762	det	the,pathway
R4189	T6762	T6760	dobj	pathway,enter
R4190	T6763	T6762	compound	NCO,pathway
R4191	T6764	T6762	compound	repair,pathway
R4192	T6765	T6741	auxpass	are,resolved
R4193	T6766	T6741	advmod	incompletely,resolved
R4194	T6767	T6741	cc	or,resolved
R4195	T6768	T6741	conj	processed,resolved
R4196	T6769	T6768	advmod	inefficiently,processed
R4197	T6770	T6739	punct	.,suggest
R4198	T6772	T6773	det	This,hypothesis
R4199	T6773	T6774	nsubj	hypothesis,is
R4200	T6775	T6774	acomp	compatible,is
R4201	T6776	T6775	prep	with,compatible
R4202	T6777	T6778	amod	current,knowledge
R4203	T6778	T6776	pobj	knowledge,with
R4204	T6779	T6778	prep	of,knowledge
R4205	T6780	T6781	amod	meiotic,recombination
R4206	T6781	T6782	compound	recombination,pathways
R4207	T6782	T6779	pobj	pathways,of
R4208	T6783	T6774	punct	.,is
R4209	T6785	T6786	prep	In,are
R4210	T6786	T6794	ccomp	are,have
R4211	T6787	T6788	compound	S.,cerevisiae
R4212	T6788	T6785	pobj	cerevisiae,In
R4213	T6789	T6786	punct	", ",are
R4214	T6790	T6791	nmod	CO,pathways
R4215	T6791	T6786	nsubj	pathways,are
R4216	T6792	T6790	cc	and,CO
R4217	T6793	T6790	conj	NCO,CO
R4218	T6795	T6786	acomp	distinct,are
R4219	T6796	T6797	punct	[,43
R4220	T6797	T6786	parataxis	43,are
R4221	T6798	T6797	punct	],43
R4222	T6799	T6794	punct	;,have
R4223	T6800	T6794	nsubj	they,have
R4224	T6801	T6802	amod	different,intermediates
R4225	T6802	T6794	dobj	intermediates,have
R4226	T6803	T6802	compound	recombination,intermediates
R4227	T6804	T6794	punct	", ",have
R4228	T6805	T6794	cc	and,have
R4229	T6806	T6794	conj	are,have
R4230	T6807	T6806	acomp	dependent,are
R4231	T6808	T6807	prep	upon,dependent
R4232	T6809	T6810	amod	different,proteins
R4233	T6810	T6808	pobj	proteins,upon
R4234	T6811	T6812	punct	[,45
R4235	T6812	T6806	parataxis	45,are
R4236	T6813	T6812	nummod	44,45
R4237	T6814	T6812	punct	",",45
R4238	T6815	T6812	punct	],45
R4239	T6816	T6794	punct	.,have
R4240	T6818	T6819	nsubj	Mice,appear
R4241	T6820	T6819	advmod	also,appear
R4242	T6821	T6822	aux	to,have
R4243	T6822	T6819	xcomp	have,appear
R4244	T6823	T6824	amod	independent,pathways
R4245	T6824	T6822	dobj	pathways,have
R4246	T6825	T6824	nmod	CO,pathways
R4247	T6826	T6825	cc	versus,CO
R4248	T6827	T6825	conj	NCO,CO
R4249	T6828	T6824	compound	recombination,pathways
R4250	T6829	T6830	punct	[,46
R4251	T6830	T6819	parataxis	46,appear
R4252	T6831	T6830	punct	],46
R4253	T6832	T6819	punct	.,appear
R4254	T6834	T6835	prep	As,require
R4255	T6836	T6834	prep	in,As
R4256	T6837	T6836	pobj	yeast,in
R4257	T6838	T6835	punct	", ",require
R4258	T6839	T6835	nsubj	both,require
R4259	T6840	T6841	npadvmod	SPO11,induced
R4260	T6841	T6843	amod	induced,breaks
R4261	T6842	T6841	punct	-,induced
R4262	T6843	T6835	dobj	breaks,require
R4263	T6844	T6835	punct	", ",require
R4264	T6845	T6835	cc	but,require
R4265	T6846	T6847	advmod	only,pathway
R4266	T6847	T6850	nsubj	pathway,requires
R4267	T6848	T6847	det	the,pathway
R4268	T6849	T6847	compound	CO,pathway
R4269	T6850	T6835	conj	requires,require
R4270	T6851	T6850	dobj	MLH1,requires
R4271	T6852	T6850	punct	.,requires
R4272	T6854	T6855	det	Both,types
R4273	T6855	T6856	nsubjpass	types,formed
R4274	T6857	T6855	prep	of,types
R4275	T6858	T6859	amod	recombinant,products
R4276	T6859	T6857	pobj	products,of
R4277	T6860	T6856	auxpass	are,formed
R4278	T6861	T6856	prep	by,formed
R4279	T6862	T6863	amod	mid,late
R4280	T6863	T6865	amod	late,pachynema
R4281	T6864	T6863	punct	-,late
R4282	T6865	T6861	pobj	pachynema,by
R4283	T6866	T6856	punct	.,formed
R4284	T6868	T6869	det	Another,possibility
R4285	T6869	T6870	nsubj	possibility,is
R4286	T6871	T6872	mark	that,are
R4287	T6872	T6870	ccomp	are,is
R4288	T6873	T6874	det	the,defects
R4289	T6874	T6872	nsubj	defects,are
R4290	T6875	T6874	compound	recombination,defects
R4291	T6876	T6877	det	a,result
R4292	T6877	T6872	attr	result,are
R4293	T6878	T6877	prep	of,result
R4294	T6879	T6880	amod	defective,recombination
R4295	T6880	T6878	pobj	recombination,of
R4296	T6881	T6880	amod	intersister,recombination
R4297	T6882	T6870	punct	.,is
R4298	T6884	T6885	advmod	However,suppressed
R4299	T6886	T6885	punct	", ",suppressed
R4300	T6887	T6888	det	this,type
R4301	T6888	T6885	nsubjpass	type,suppressed
R4302	T6889	T6888	prep	of,type
R4303	T6890	T6891	compound	DSB,repair
R4304	T6891	T6889	pobj	repair,of
R4305	T6892	T6885	auxpass	is,suppressed
R4306	T6893	T6885	prep	in,suppressed
R4307	T6894	T6895	amod	meiotic,cells
R4308	T6895	T6893	pobj	cells,in
R4309	T6896	T6885	punct	.,suppressed
R4310	T6898	T6899	nsubj	Ablation,disrupt
R4311	T6900	T6898	prep	of,Ablation
R4312	T6901	T6900	pobj	RAD54,of
R4313	T6902	T6901	punct	", ",RAD54
R4314	T6903	T6904	dep	which,mediates
R4315	T6904	T6901	relcl	mediates,RAD54
R4316	T6905	T6906	amod	intersister,recombination
R4317	T6906	T6904	dobj	recombination,mediates
R4318	T6907	T6906	prep	in,recombination
R4319	T6908	T6907	pobj	yeast,in
R4320	T6909	T6899	punct	", ",disrupt
R4321	T6910	T6899	aux	does,disrupt
R4322	T6911	T6899	neg	not,disrupt
R4323	T6912	T6899	advmod	significantly,disrupt
R4324	T6913	T6899	dobj	meiosis,disrupt
R4325	T6914	T6899	prep	in,disrupt
R4326	T6915	T6916	preconj	either,yeast
R4327	T6916	T6914	pobj	yeast,in
R4328	T6917	T6916	cc	or,yeast
R4329	T6918	T6916	conj	mice,yeast
R4330	T6919	T6920	punct	[,48
R4331	T6920	T6899	parataxis	48,disrupt
R4332	T6921	T6920	nummod	47,48
R4333	T6922	T6920	punct	",",48
R4334	T6923	T6920	punct	],48
R4335	T6924	T6899	punct	.,disrupt
R4336	T6926	T6927	advmod	Interestingly,display
R4337	T6928	T6927	punct	", ",display
R4338	T6929	T6930	npadvmod	RAD54,deficient
R4339	T6930	T6932	amod	deficient,spermatocytes
R4340	T6931	T6930	punct	-,deficient
R4341	T6932	T6927	nsubj	spermatocytes,display
R4342	T6933	T6934	amod	abnormal,persistence
R4343	T6934	T6927	dobj	persistence,display
R4344	T6935	T6934	prep	of,persistence
R4345	T6936	T6937	compound	RAD51,foci
R4346	T6937	T6935	pobj	foci,of
R4347	T6938	T6927	prep	on,display
R4348	T6939	T6940	compound	pachytene,chromosomes
R4349	T6940	T6938	pobj	chromosomes,on
R4350	T6941	T6940	punct	", ",chromosomes
R4351	T6942	T6940	amod	similar,chromosomes
R4352	T6943	T6942	prep	to,similar
R4353	T6944	T6943	pobj	those,to
R4354	T6945	T6944	prep	in,those
R4355	T6946	T6947	compound	TRIP13,mice
R4356	T6947	T6945	pobj	mice,in
R4357	T6948	T6927	punct	", ",display
R4358	T6949	T6927	cc	but,display
R4359	T6950	T6951	expl	there,are
R4360	T6951	T6927	conj	are,display
R4361	T6952	T6953	det	no,effects
R4362	T6953	T6951	attr	effects,are
R4363	T6954	T6953	amod	deleterious,effects
R4364	T6955	T6953	prep	on,effects
R4365	T6956	T6957	amod	meiotic,progression
R4366	T6957	T6955	pobj	progression,on
R4367	T6958	T6957	cc	or,progression
R4368	T6959	T6957	conj	fertility,progression
R4369	T6960	T6961	punct	[,49
R4370	T6961	T6951	parataxis	49,are
R4371	T6962	T6961	punct	],49
R4372	T6963	T6951	punct	.,are
R4373	T6965	T6966	nsubj	Data,indicate
R4374	T6967	T6965	prep	from,Data
R4375	T6968	T6969	amod	budding,yeast
R4376	T6969	T6967	pobj	yeast,from
R4377	T6970	T6966	advmod	also,indicate
R4378	T6971	T6972	mark	that,functions
R4379	T6972	T6966	ccomp	functions,indicate
R4380	T6973	T6972	nsubj	Pch2p,functions
R4381	T6974	T6972	prep	in,functions
R4382	T6975	T6974	pobj	recombination,in
R4383	T6976	T6966	punct	.,indicate
R4384	T6978	T6979	nsubj	Deletion,delays
R4385	T6980	T6978	prep	of,Deletion
R4386	T6981	T6980	pobj	PCH2,of
R4387	T6982	T6983	amod	meiotic,progression
R4388	T6983	T6979	dobj	progression,delays
R4389	T6984	T6979	prep	by,delays
R4390	T6985	T6986	punct	∼,2
R4391	T6986	T6987	nummod	2,h
R4392	T6987	T6984	pobj	h,by
R4393	T6988	T6979	prep	in,delays
R4394	T6989	T6990	compound	SK1,yeast
R4395	T6990	T6988	pobj	yeast,in
R4396	T6991	T6979	punct	", ",delays
R4397	T6992	T6979	cc	and,delays
R4398	T6993	T6979	conj	causes,delays
R4399	T6994	T6995	det	a,decrease
R4400	T6995	T6993	dobj	decrease,causes
R4401	T6996	T6995	amod	minor,decrease
R4402	T6997	T6995	prep	in,decrease
R4403	T6998	T6999	compound	ascus,formation
R4404	T6999	T6997	pobj	formation,in
R4405	T7000	T7001	punct	[,50
R4406	T7001	T6993	parataxis	50,causes
R4407	T7002	T7001	punct	],50
R4408	T7003	T6979	punct	.,delays
R4409	T7005	T7006	nsubj	DSBs,persist
R4410	T7007	T7008	punct	>,2
R4411	T7008	T7009	nummod	2,h
R4412	T7009	T7010	npadvmod	h,longer
R4413	T7010	T7006	advmod	longer,persist
R4414	T7011	T7006	prep	in,persist
R4415	T7012	T7013	nmod	pch2,yeast
R4416	T7013	T7011	pobj	yeast,in
R4417	T7014	T7013	punct	Δ,yeast
R4418	T7015	T7006	prep	than,persist
R4419	T7016	T7015	prep	in,than
R4420	T7017	T7018	amod	wild,type
R4421	T7018	T7016	pobj	type,in
R4422	T7019	T7006	punct	", ",persist
R4423	T7020	T7006	cc	and,persist
R4424	T7021	T7022	nsubj	hyperresection,is
R4425	T7022	T7006	conj	is,persist
R4426	T7023	T7021	prep	of,hyperresection
R4427	T7024	T7023	pobj	DSBs,of
R4428	T7025	T7021	prep	in,hyperresection
R4429	T7026	T7027	nmod	dmc1,pch2
R4430	T7027	T7029	nmod	pch2,mutants
R4431	T7028	T7027	punct	Δ,pch2
R4432	T7029	T7025	pobj	mutants,in
R4433	T7030	T7027	punct	Δ,pch2
R4434	T7031	T7029	amod	double,mutants
R4435	T7032	T7022	acomp	lower,is
R4436	T7033	T7032	prep	than,lower
R4437	T7034	T7033	prep	in,than
R4438	T7035	T7036	nmod	dmc1,cells
R4439	T7036	T7034	pobj	cells,in
R4440	T7037	T7035	punct	Δ,dmc1
R4441	T7038	T7039	punct	[,10
R4442	T7039	T7022	parataxis	10,is
R4443	T7040	T7039	punct	],10
R4444	T7041	T7022	punct	.,is
R4445	T7043	T7044	advmod	Additionally,reported
R4446	T7045	T7044	punct	", ",reported
R4447	T7046	T7044	nsubjpass	it,reported
R4448	T7047	T7044	auxpass	was,reported
R4449	T7048	T7049	mark	that,had
R4450	T7049	T7044	ccomp	had,reported
R4451	T7050	T7051	compound	pch2,Δ
R4452	T7051	T7052	compound	Δ,yeast
R4453	T7052	T7049	nsubj	yeast,had
R4454	T7053	T7054	det	a,delay
R4455	T7054	T7049	dobj	delay,had
R4456	T7055	T7054	nmod	meiosis,delay
R4457	T7056	T7055	nummod	I,meiosis
R4458	T7057	T7054	amod	dependent,delay
R4459	T7058	T7057	prep	on,dependent
R4460	T7059	T7060	det	the,checkpoint
R4461	T7060	T7058	pobj	checkpoint,on
R4462	T7061	T7062	compound	RAD17,SAE2
R4463	T7062	T7060	compound	SAE2,checkpoint
R4464	T7063	T7062	punct	–,SAE2
R4465	T7064	T7065	dep	that,monitors
R4466	T7065	T7060	relcl	monitors,checkpoint
R4467	T7066	T7067	compound	recombination,intermediates
R4468	T7067	T7065	dobj	intermediates,monitors
R4469	T7068	T7069	punct	[,12
R4470	T7069	T7044	parataxis	12,reported
R4471	T7070	T7069	punct	],12
R4472	T7071	T7044	punct	.,reported
R4473	T7073	T7074	advmod	However,is
R4474	T7075	T7074	punct	", ",is
R4475	T7076	T7077	det	the,role
R4476	T7077	T7074	nsubj	role,is
R4477	T7078	T7077	amod	exact,role
R4478	T7079	T7077	prep	of,role
R4479	T7080	T7079	pobj	TRIP13,of
R4480	T7081	T7080	punct	(,TRIP13
R4481	T7082	T7080	cc	or,TRIP13
R4482	T7083	T7080	conj	Pch2,TRIP13
R4483	T7084	T7077	punct	),role
R4484	T7085	T7077	prep	in,role
R4485	T7086	T7085	pobj	recombination,in
R4486	T7087	T7074	acomp	unclear,is
R4487	T7088	T7074	punct	.,is
R4488	T7090	T7091	mark	Because,occurs
R4489	T7091	T7093	advcl	occurs,suggest
R4490	T7092	T7091	nsubj	synapsis,occurs
R4491	T7094	T7091	prep	in,occurs
R4492	T7095	T7096	npadvmod	TRIP13,deficient
R4493	T7096	T7098	amod	deficient,spermatocytes
R4494	T7097	T7096	punct	-,deficient
R4495	T7098	T7094	pobj	spermatocytes,in
R4496	T7099	T7091	cc	and,occurs
R4497	T7100	T7091	conj	is,occurs
R4498	T7101	T7100	acomp	dependent,is
R4499	T7102	T7101	prep	on,dependent
R4500	T7103	T7104	compound	DSB,formation
R4501	T7104	T7102	pobj	formation,on
R4502	T7105	T7104	punct	(,formation
R4503	T7106	T7104	appos	activity,formation
R4504	T7107	T7106	prep	of,activity
R4505	T7108	T7107	pobj	SPO11,of
R4506	T7109	T7108	cc	and,SPO11
R4507	T7110	T7108	conj	MEI1,SPO11
R4508	T7111	T7093	punct	),suggest
R4509	T7112	T7093	punct	", ",suggest
R4510	T7113	T7093	nsubj	we,suggest
R4511	T7114	T7115	mark	that,functions
R4512	T7115	T7093	advcl	functions,suggest
R4513	T7116	T7115	nsubj	TRIP13,functions
R4514	T7117	T7115	prep	after,functions
R4515	T7118	T7119	compound	homology,recognition
R4516	T7119	T7117	pobj	recognition,after
R4517	T7120	T7119	cc	and,recognition
R4518	T7121	T7122	compound	strand,exchange
R4519	T7122	T7119	conj	exchange,recognition
R4520	T7123	T7115	punct	", ",functions
R4521	T7124	T7115	cc	and,functions
R4522	T7125	T7126	mark	that,are
R4523	T7126	T7115	conj	are,functions
R4524	T7127	T7128	compound	recombination,events
R4525	T7128	T7126	nsubj	events,are
R4526	T7129	T7128	acl	entering,events
R4527	T7130	T7131	det	the,pathway
R4528	T7131	T7129	dobj	pathway,entering
R4529	T7132	T7133	compound	CO,repair
R4530	T7133	T7131	compound	repair,pathway
R4531	T7134	T7135	advmod	either,completed
R4532	T7135	T7126	acomp	completed,are
R4533	T7136	T7135	cc	or,completed
R4534	T7137	T7138	advmod	nearly,so
R4535	T7138	T7135	conj	so,completed
R4536	T7139	T7126	punct	(,are
R4537	T7140	T7141	mark	because,resulted
R4538	T7141	T7126	advcl	resulted,are
R4539	T7142	T7141	nsubj	OA,resulted
R4540	T7143	T7142	amod	treated,OA
R4541	T7144	T7141	prep	in,resulted
R4542	T7145	T7146	amod	bivalent,chromosomes
R4543	T7146	T7144	pobj	chromosomes,in
R4544	T7147	T7093	punct	),suggest
R4545	T7148	T7093	punct	.,suggest
R4546	T7150	T7151	nummod	One,possibility
R4547	T7151	T7152	nsubj	possibility,is
R4548	T7153	T7151	prep	for,possibility
R4549	T7154	T7155	poss	TRIP13,role
R4550	T7155	T7153	pobj	role,for
R4551	T7156	T7154	case	′s,TRIP13
R4552	T7157	T7155	prep	in,role
R4553	T7158	T7157	pobj	recombination,in
R4554	T7159	T7160	mark	that,involved
R4555	T7160	T7152	ccomp	involved,is
R4556	T7161	T7160	nsubjpass	it,involved
R4557	T7162	T7160	auxpass	is,involved
R4558	T7163	T7160	advmod	directly,involved
R4559	T7164	T7160	prep	in,involved
R4560	T7165	T7166	det	a,step
R4561	T7166	T7164	pobj	step,in
R4562	T7167	T7166	amod	specific,step
R4563	T7168	T7167	prep	to,specific
R4564	T7169	T7168	pobj	resolution,to
R4565	T7170	T7169	prep	of,resolution
R4566	T7171	T7172	compound	NCO,recombination
R4567	T7172	T7173	compound	recombination,intermediates
R4568	T7173	T7170	pobj	intermediates,of
R4569	T7174	T7152	punct	.,is
R4570	T7176	T7177	det	Another,possibility
R4571	T7177	T7178	nsubj	possibility,is
R4572	T7179	T7180	mark	that,required
R4573	T7180	T7178	ccomp	required,is
R4574	T7181	T7180	nsubjpass	TRIP13,required
R4575	T7182	T7180	auxpass	is,required
R4576	T7183	T7180	prep	for,required
R4577	T7184	T7183	pobj	disassembly,for
R4578	T7185	T7184	prep	of,disassembly
R4579	T7186	T7187	npadvmod	NCO,recombinational
R4580	T7187	T7188	amod	recombinational,repair
R4581	T7188	T7189	compound	repair,complexes
R4582	T7189	T7185	pobj	complexes,of
R4583	T7190	T7191	punct	[,51
R4584	T7191	T7189	parataxis	51,complexes
R4585	T7192	T7191	punct	],51
R4586	T7193	T7189	acl	containing,complexes
R4587	T7194	T7195	det	those,proteins
R4588	T7195	T7193	dobj	proteins,containing
R4589	T7196	T7197	dep	that,persist
R4590	T7197	T7195	relcl	persist,proteins
R4591	T7198	T7197	advmod	abnormally,persist
R4592	T7199	T7197	prep	on,persist
R4593	T7200	T7201	compound	Trip13Gt,Gt
R4594	T7201	T7203	compound	Gt,chromosomes
R4595	T7202	T7201	punct	/,Gt
R4596	T7203	T7199	pobj	chromosomes,on
R4597	T7204	T7203	compound	pachytene,chromosomes
R4598	T7205	T7178	punct	.,is
R4599	T7207	T7208	advmod	Notably,has
R4600	T7209	T7208	punct	", ",has
R4601	T7210	T7208	nsubj	TRIP13,has
R4602	T7211	T7212	nummod	two,domains
R4603	T7212	T7208	dobj	domains,has
R4604	T7213	T7212	amod	putative,domains
R4605	T7214	T7212	compound	ATPase,domains
R4606	T7215	T7212	punct	", ",domains
R4607	T7216	T7217	det	a,signature
R4608	T7217	T7212	appos	signature,domains
R4609	T7218	T7217	prep	of,signature
R4610	T7219	T7220	compound	AAA,ATPase
R4611	T7220	T7222	compound	ATPase,chaperones
R4612	T7221	T7220	punct	-,ATPase
R4613	T7222	T7218	pobj	chaperones,of
R4614	T7223	T7224	compound	ClpA,B
R4615	T7224	T7222	compound	B,chaperones
R4616	T7225	T7224	punct	/,B
R4617	T7226	T7227	dep	that,perform
R4618	T7227	T7222	relcl	perform,chaperones
R4619	T7228	T7229	nmod	protein,disassembly
R4620	T7229	T7227	dobj	disassembly,perform
R4621	T7230	T7228	cc	or,protein
R4622	T7231	T7232	compound	protein,DNA
R4623	T7232	T7234	compound	DNA,complex
R4624	T7233	T7232	punct	/,DNA
R4625	T7234	T7228	conj	complex,protein
R4626	T7235	T7236	punct	[,52
R4627	T7236	T7208	parataxis	52,has
R4628	T7237	T7236	punct	],52
R4629	T7238	T7208	punct	.,has
R4630	T7240	T7241	det	These,roles
R4631	T7241	T7244	nsubjpass	roles,limited
R4632	T7242	T7241	amod	potential,roles
R4633	T7243	T7241	compound	recombination,roles
R4634	T7245	T7244	aux	might,limited
R4635	T7246	T7244	neg	not,limited
R4636	T7247	T7244	auxpass	be,limited
R4637	T7248	T7244	prep	to,limited
R4638	T7249	T7248	pobj	meiosis,to
R4639	T7250	T7244	punct	", ",limited
R4640	T7251	T7252	mark	since,transcribed
R4641	T7252	T7244	advcl	transcribed,limited
R4642	T7253	T7252	nsubjpass	Trip13,transcribed
R4643	T7254	T7252	auxpass	is,transcribed
R4644	T7255	T7252	advmod	widely,transcribed
R4645	T7256	T7252	cc	and,transcribed
R4646	T7257	T7258	det	the,animals
R4647	T7258	T7260	nsubj	animals,exhibited
R4648	T7259	T7258	compound	mutant,animals
R4649	T7260	T7252	conj	exhibited,transcribed
R4650	T7261	T7262	amod	developmental,defects
R4651	T7262	T7260	dobj	defects,exhibited
R4652	T7263	T7244	punct	.,limited
R4653	T7265	T7266	advmod	Finally,play
R4654	T7267	T7266	punct	", ",play
R4655	T7268	T7266	nsubj	TRIP13,play
R4656	T7269	T7266	aux	might,play
R4657	T7270	T7271	det	an,role
R4658	T7271	T7266	dobj	role,play
R4659	T7272	T7271	amod	indirect,role
R4660	T7273	T7271	punct	", ",role
R4661	T7274	T7275	amod	such,as
R4662	T7275	T7271	prep	as,role
R4663	T7276	T7275	pcomp	providing,as
R4664	T7277	T7278	det	a,signal
R4665	T7278	T7276	dobj	signal,providing
R4666	T7279	T7278	punct	“,signal
R4667	T7280	T7278	nmod	licensing,signal
R4668	T7281	T7278	punct	”,signal
R4669	T7282	T7278	prep	for,signal
R4670	T7283	T7284	det	the,resolution
R4671	T7284	T7282	pobj	resolution,for
R4672	T7285	T7284	prep	of,resolution
R4673	T7286	T7287	compound	NCO,intermediates
R4674	T7287	T7285	pobj	intermediates,of
R4675	T7288	T7284	cc	and,resolution
R4676	T7289	T7284	conj	completion,resolution
R4677	T7290	T7289	prep	of,completion
R4678	T7291	T7290	pobj	meiosis,of
R4679	T7292	T7266	punct	.,play
R4680	T7294	T7295	prep	Regarding,indicate
R4681	T7296	T7297	det	the,cause
R4682	T7297	T7294	pobj	cause,Regarding
R4683	T7298	T7297	prep	of,cause
R4684	T7299	T7300	compound	cell,death
R4685	T7300	T7298	pobj	death,of
R4686	T7301	T7300	prep	in,death
R4687	T7302	T7303	compound	Trip13,mutants
R4688	T7303	T7301	pobj	mutants,in
R4689	T7304	T7295	punct	", ",indicate
R4690	T7305	T7306	poss	our,data
R4691	T7306	T7295	nsubj	data,indicate
R4692	T7307	T7308	mark	that,triggered
R4693	T7308	T7295	ccomp	triggered,indicate
R4694	T7309	T7308	nsubjpass	this,triggered
R4695	T7310	T7308	auxpass	is,triggered
R4696	T7311	T7308	agent	by,triggered
R4697	T7312	T7313	amod	defective,repair
R4698	T7313	T7311	pobj	repair,by
R4699	T7314	T7313	compound	DSB,repair
R4700	T7315	T7316	advmod	rather,than
R4701	T7316	T7313	prep	than,repair
R4702	T7317	T7316	pobj	asynapsis,than
R4703	T7318	T7295	punct	.,indicate
R4704	T7320	T7321	nsubj	We,base
R4705	T7321	T7322	ccomp	base,is
R4706	T7323	T7324	det	this,conclusion
R4707	T7324	T7321	dobj	conclusion,base
R4708	T7325	T7324	prep	on,conclusion
R4709	T7326	T7327	nummod	two,observations
R4710	T7327	T7325	pobj	observations,on
R4711	T7328	T7322	punct	: ,is
R4712	T7329	T7330	punct	(,1
R4713	T7330	T7322	meta	1,is
R4714	T7331	T7330	punct	),1
R4715	T7332	T7333	compound	oocyte,elimination
R4716	T7333	T7322	nsubj	elimination,is
R4717	T7334	T7322	acomp	dependent,is
R4718	T7335	T7334	prep	upon,dependent
R4719	T7336	T7337	compound	DSB,formation
R4720	T7337	T7335	pobj	formation,upon
R4721	T7338	T7322	cc	and,is
R4722	T7339	T7340	punct	(,2
R4723	T7340	T7341	meta	2,is
R4724	T7341	T7322	conj	is,is
R4725	T7342	T7340	punct	),2
R4726	T7343	T7341	nsubj	synapsis,is
R4727	T7344	T7341	acomp	normal,is
R4728	T7345	T7341	prep	in,is
R4729	T7346	T7345	pobj	spermatocytes,in
R4730	T7347	T7346	prep	of,spermatocytes
R4731	T7348	T7349	amod	adult,testes
R4732	T7349	T7347	pobj	testes,of
R4733	T7350	T7322	punct	.,is
R4734	T7352	T7353	advmod	Indeed,is
R4735	T7354	T7353	punct	", ",is
R4736	T7355	T7356	det	this,mutant
R4737	T7356	T7353	nsubj	mutant,is
R4738	T7357	T7353	acomp	unique,is
R4739	T7358	T7359	mark	in,occur
R4740	T7359	T7353	advcl	occur,is
R4741	T7360	T7359	mark	that,occur
R4742	T7361	T7362	compound	recombination,defects
R4743	T7362	T7359	nsubj	defects,occur
R4744	T7363	T7359	prep	in,occur
R4745	T7364	T7365	det	the,absence
R4746	T7365	T7363	pobj	absence,in
R4747	T7366	T7365	prep	of,absence
R4748	T7367	T7366	pobj	asynapsis,of
R4749	T7368	T7369	punct	(,as
R4750	T7369	T7359	parataxis	as,occur
R4751	T7370	T7369	advmod	e.g.,as
R4752	T7371	T7369	punct	", ",as
R4753	T7372	T7369	prep	in,as
R4754	T7373	T7374	compound	Dmc1,knockouts
R4755	T7374	T7372	pobj	knockouts,in
R4756	T7375	T7369	punct	),as
R4757	T7376	T7353	punct	.,is
R4758	T7378	T7379	advmod	Thus,provides
R4759	T7380	T7379	punct	", ",provides
R4760	T7381	T7382	det	the,mutant
R4761	T7382	T7379	nsubj	mutant,provides
R4762	T7383	T7382	compound	Trip13,mutant
R4763	T7384	T7385	det	the,evidence
R4764	T7385	T7379	dobj	evidence,provides
R4765	T7386	T7385	amod	first,evidence
R4766	T7387	T7388	mark	that,trigger
R4767	T7388	T7385	acl	trigger,evidence
R4768	T7389	T7390	amod	unrepaired,damage
R4769	T7390	T7388	nsubj	damage,trigger
R4770	T7391	T7390	compound	DNA,damage
R4771	T7392	T7390	advmod	alone,damage
R4772	T7393	T7388	aux	can,trigger
R4773	T7394	T7395	det	the,response
R4774	T7395	T7388	dobj	response,trigger
R4775	T7396	T7395	amod	mammalian,response
R4776	T7397	T7398	compound	pachytene,checkpoint
R4777	T7398	T7395	compound	checkpoint,response
R4778	T7399	T7379	punct	.,provides
R4779	T7401	T7402	advmod	Furthermore,allow
R4780	T7403	T7402	punct	", ",allow
R4781	T7404	T7405	poss	our,results
R4782	T7405	T7402	nsubj	results,allow
R4783	T7406	T7407	nsubj	us,conclude
R4784	T7407	T7402	ccomp	conclude,allow
R4785	T7408	T7407	aux	to,conclude
R4786	T7409	T7410	mark	that,share
R4787	T7410	T7407	ccomp	share,conclude
R4788	T7411	T7410	nsubj	oocytes,share
R4789	T7412	T7411	cc	and,oocytes
R4790	T7413	T7411	conj	spermatocytes,oocytes
R4791	T7414	T7415	det	a,checkpoint
R4792	T7415	T7410	dobj	checkpoint,share
R4793	T7416	T7415	amod	similar,checkpoint
R4794	T7417	T7416	punct	", ",similar
R4795	T7418	T7416	cc	if,similar
R4796	T7419	T7418	neg	not,if
R4797	T7420	T7416	conj	identical,similar
R4798	T7421	T7415	punct	", ",checkpoint
R4799	T7422	T7423	compound	DNA,damage
R4800	T7423	T7415	compound	damage,checkpoint
R4801	T7424	T7415	compound	pachytene,checkpoint
R4802	T7425	T7426	dep	that,decoupled
R4803	T7426	T7415	relcl	decoupled,checkpoint
R4804	T7427	T7426	auxpass	is,decoupled
R4805	T7428	T7426	prep	from,decoupled
R4806	T7429	T7430	det	a,checkpoint
R4807	T7430	T7428	pobj	checkpoint,from
R4808	T7431	T7430	compound	synapsis,checkpoint
R4809	T7432	T7402	punct	.,allow
R4810	T7434	T7435	advmod	Interestingly,found
R4811	T7436	T7435	punct	", ",found
R4812	T7437	T7435	nsubj	we,found
R4813	T7438	T7439	mark	that,propel
R4814	T7439	T7435	ccomp	propel,found
R4815	T7440	T7441	compound	OA,treatment
R4816	T7441	T7439	nsubj	treatment,propel
R4817	T7442	T7441	prep	of,treatment
R4818	T7443	T7444	compound	Trip13Gt,Gt
R4819	T7444	T7446	compound	Gt,spermatocytes
R4820	T7445	T7444	punct	/,Gt
R4821	T7446	T7442	pobj	spermatocytes,of
R4822	T7447	T7439	aux	could,propel
R4823	T7448	T7439	dobj	them,propel
R4824	T7449	T7439	prep	into,propel
R4825	T7450	T7449	pobj	MI,into
R4826	T7451	T7439	punct	", ",propel
R4827	T7452	T7439	prep	despite,propel
R4828	T7453	T7454	det	a,report
R4829	T7454	T7452	pobj	report,despite
R4830	T7455	T7456	mark	that,occur
R4831	T7456	T7454	acl	occur,report
R4832	T7457	T7458	det	the,same
R4833	T7458	T7456	nsubj	same,occur
R4834	T7459	T7456	aux	did,occur
R4835	T7460	T7456	neg	not,occur
R4836	T7461	T7462	advmod	when,treated
R4837	T7462	T7456	advcl	treated,occur
R4838	T7463	T7464	amod	wild,type
R4839	T7464	T7466	compound	type,spermatocytes
R4840	T7465	T7464	punct	-,type
R4841	T7466	T7462	nsubjpass	spermatocytes,treated
R4842	T7467	T7466	compound	pachytene,spermatocytes
R4843	T7468	T7462	auxpass	were,treated
R4844	T7469	T7462	prep	with,treated
R4845	T7470	T7471	det	the,agents
R4846	T7471	T7469	pobj	agents,with
R4847	T7472	T7473	npadvmod	DSB,inducing
R4848	T7473	T7471	amod	inducing,agents
R4849	T7474	T7473	punct	-,inducing
R4850	T7475	T7476	compound	gamma,radiation
R4851	T7476	T7471	appos	radiation,agents
R4852	T7477	T7476	cc	or,radiation
R4853	T7478	T7476	conj	etoposide,radiation
R4854	T7479	T7480	punct	[,53
R4855	T7480	T7435	parataxis	53,found
R4856	T7481	T7480	punct	],53
R4857	T7482	T7435	punct	.,found
R4858	T7484	T7485	nsubj	It,is
R4859	T7486	T7485	acomp	possible,is
R4860	T7487	T7488	mark	that,evokes
R4861	T7488	T7485	ccomp	evokes,is
R4862	T7489	T7490	det	the,induction
R4863	T7490	T7488	nsubj	induction,evokes
R4864	T7491	T7490	amod	nascent,induction
R4865	T7492	T7490	prep	of,induction
R4866	T7493	T7492	pobj	DSBs,of
R4867	T7494	T7490	prep	in,induction
R4868	T7495	T7494	pobj	pachynema,in
R4869	T7496	T7497	det	a,response
R4870	T7497	T7488	dobj	response,evokes
R4871	T7498	T7497	compound	checkpoint,response
R4872	T7499	T7500	dep	that,bypassed
R4873	T7500	T7497	relcl	bypassed,response
R4874	T7501	T7500	aux	can,bypassed
R4875	T7502	T7500	neg	not,bypassed
R4876	T7503	T7500	auxpass	be,bypassed
R4877	T7504	T7500	agent	by,bypassed
R4878	T7505	T7504	pobj	OA,by
R4879	T7506	T7488	punct	", ",evokes
R4880	T7507	T7508	mark	whereas,do
R4881	T7508	T7488	advcl	do,evokes
R4882	T7509	T7510	det	the,lesions
R4883	T7510	T7508	nsubj	lesions,do
R4884	T7511	T7510	nmod	post-strand,lesions
R4885	T7512	T7511	advmod	invasion,post-strand
R4886	T7513	T7510	prep	in,lesions
R4887	T7514	T7515	npadvmod	TRIP13,deficient
R4888	T7515	T7517	amod	deficient,spermatocytes
R4889	T7516	T7515	punct	-,deficient
R4890	T7517	T7513	pobj	spermatocytes,in
R4891	T7518	T7508	neg	not,do
R4892	T7519	T7485	punct	.,is
R4893	T7521	T7522	nsubjpass	TRIP13,discovered
R4894	T7523	T7522	auxpass	was,discovered
R4895	T7524	T7522	advmod	originally,discovered
R4896	T7525	T7526	aux	to,be
R4897	T7526	T7522	xcomp	be,discovered
R4898	T7527	T7528	det	an,interactor
R4899	T7528	T7526	attr	interactor,be
R4900	T7529	T7528	prep	with,interactor
R4901	T7530	T7531	compound	rat,beta
R4902	T7531	T7529	pobj	beta,with
R4903	T7532	T7531	compound	thyroid,beta
R4904	T7533	T7531	compound	receptor,beta
R4905	T7534	T7531	punct	(,beta
R4906	T7535	T7531	appos	THRB,beta
R4907	T7536	T7526	punct	;,be
R4908	T7537	T7538	punct	[,54
R4909	T7538	T7526	parataxis	54,be
R4910	T7539	T7538	punct	],54
R4911	T7540	T7522	punct	),discovered
R4912	T7541	T7522	punct	", ",discovered
R4913	T7542	T7522	cc	but,discovered
R4914	T7543	T7544	det	the,relationship
R4915	T7544	T7545	nsubj	relationship,is
R4916	T7545	T7522	conj	is,discovered
R4917	T7546	T7544	prep	between,relationship
R4918	T7547	T7546	pobj	THRB,between
R4919	T7548	T7547	cc	and,THRB
R4920	T7549	T7547	conj	TRIP13,THRB
R4921	T7550	T7544	prep	in,relationship
R4922	T7551	T7550	pobj	meiosis,in
R4923	T7552	T7545	acomp	unknown,is
R4924	T7553	T7545	punct	.,is
R4925	T7555	T7556	advmod	Interestingly,observed
R4926	T7557	T7556	punct	", ",observed
R4927	T7558	T7556	nsubj	we,observed
R4928	T7559	T7560	mark	that,distributed
R4929	T7560	T7556	ccomp	distributed,observed
R4930	T7561	T7560	nsubjpass	THRB,distributed
R4931	T7562	T7560	auxpass	is,distributed
R4932	T7563	T7560	advmod	diffusely,distributed
R4933	T7564	T7560	prep	throughout,distributed
R4934	T7565	T7566	amod	wild,type
R4935	T7566	T7568	compound	type,nuclei
R4936	T7567	T7566	punct	-,type
R4937	T7568	T7564	pobj	nuclei,throughout
R4938	T7569	T7568	compound	spermatocyte,nuclei
R4939	T7570	T7560	cc	but,distributed
R4940	T7571	T7572	auxpass	is,excluded
R4941	T7572	T7560	conj	excluded,distributed
R4942	T7573	T7572	prep	from,excluded
R4943	T7574	T7575	det	the,body
R4944	T7575	T7573	pobj	body,from
R4945	T7576	T7575	nmod	XY,body
R4946	T7577	T7578	punct	(,sex
R4947	T7578	T7575	parataxis	sex,body
R4948	T7579	T7578	punct	),sex
R4949	T7580	T7581	punct	(,observations
R4950	T7581	T7575	meta	observations,body
R4951	T7582	T7581	amod	unpublished,observations
R4952	T7583	T7581	punct	),observations
R4953	T7584	T7575	punct	", ",body
R4954	T7585	T7586	det	a,domain
R4955	T7586	T7575	appos	domain,body
R4956	T7587	T7586	amod	compartmentalized,domain
R4957	T7588	T7586	amod	nuclear,domain
R4958	T7589	T7586	acl	beginning,domain
R4959	T7590	T7589	prep	in,beginning
R4960	T7591	T7590	pobj	pachynema,in
R4961	T7592	T7591	punct	", ",pachynema
R4962	T7593	T7594	prep	in,become
R4963	T7594	T7591	relcl	become,pachynema
R4964	T7595	T7593	pobj	which,in
R4965	T7596	T7597	det	the,chromosomes
R4966	T7597	T7594	nsubj	chromosomes,become
R4967	T7598	T7597	compound	sex,chromosomes
R4968	T7599	T7594	acomp	heterochromatinized,become
R4969	T7600	T7599	cc	and,heterochromatinized
R4970	T7601	T7602	advmod	transcriptionally,silenced
R4971	T7602	T7599	conj	silenced,heterochromatinized
R4972	T7603	T7594	prep	in,become
R4973	T7604	T7605	det	the,process
R4974	T7605	T7603	pobj	process,in
R4975	T7606	T7605	prep	of,process
R4976	T7607	T7606	pobj	MSCI,of
R4977	T7608	T7609	punct	[,55
R4978	T7609	T7572	parataxis	55,excluded
R4979	T7610	T7609	punct	],55
R4980	T7611	T7556	punct	.,observed
R4981	T7613	T7614	advmod	However,appeared
R4982	T7615	T7614	punct	", ",appeared
R4983	T7616	T7617	det	the,body
R4984	T7617	T7614	nsubj	body,appeared
R4985	T7618	T7617	compound	XY,body
R4986	T7619	T7614	oprd	intact,appeared
R4987	T7620	T7614	prep	in,appeared
R4988	T7621	T7622	amod	most,spermatocytes
R4989	T7622	T7620	pobj	spermatocytes,in
R4990	T7623	T7622	compound	mutant,spermatocytes
R4991	T7624	T7614	prep	upon,appeared
R4992	T7625	T7624	pcomp	probing,upon
R4993	T7626	T7625	prep	with,probing
R4994	T7627	T7628	amod	several,markers
R4995	T7628	T7626	pobj	markers,with
R4996	T7629	T7628	prep	of,markers
R4997	T7630	T7631	compound	XY,heterochromatinization
R4998	T7631	T7629	pobj	heterochromatinization,of
R4999	T7632	T7633	punct	(,observations
R5000	T7633	T7614	meta	observations,appeared
R5001	T7634	T7633	amod	unpublished,observations
R5002	T7635	T7633	punct	),observations
R5003	T7636	T7614	punct	.,appeared
R5004	T7638	T7639	advcl	Considering,is
R5005	T7640	T7641	mark	that,are
R5006	T7641	T7638	ccomp	are,Considering
R5007	T7642	T7643	compound	THRB,knockout
R5008	T7643	T7644	compound	knockout,mice
R5009	T7644	T7641	nsubj	mice,are
R5010	T7645	T7641	acomp	viable,are
R5011	T7646	T7645	cc	and,viable
R5012	T7647	T7645	conj	fertile,viable
R5013	T7648	T7649	punct	[,56
R5014	T7649	T7641	parataxis	56,are
R5015	T7650	T7649	punct	],56
R5016	T7651	T7639	punct	", ",is
R5017	T7652	T7653	det	the,relationship
R5018	T7653	T7639	nsubj	relationship,is
R5019	T7654	T7653	amod	functional,relationship
R5020	T7655	T7653	prep	between,relationship
R5021	T7656	T7655	pobj	TRIP13,between
R5022	T7657	T7656	cc	and,TRIP13
R5023	T7658	T7659	poss	its,receptor
R5024	T7659	T7656	conj	receptor,TRIP13
R5025	T7660	T7659	appos	THRB,receptor
R5026	T7661	T7653	prep	in,relationship
R5027	T7662	T7661	pobj	meiosis,in
R5028	T7663	T7639	acomp	unclear,is
R5029	T7664	T7639	punct	.,is
R5030	T7666	T7667	prep	Given,conserved
R5031	T7668	T7669	det	the,similarity
R5032	T7669	T7666	pobj	similarity,Given
R5033	T7670	T7669	amod	high,similarity
R5034	T7671	T7669	prep	of,similarity
R5035	T7672	T7673	compound	PCH2,orthologs
R5036	T7673	T7671	pobj	orthologs,of
R5037	T7674	T7669	prep	throughout,similarity
R5038	T7675	T7676	det	the,world
R5039	T7676	T7674	pobj	world,throughout
R5040	T7677	T7676	amod	eukaryotic,world
R5041	T7678	T7667	punct	", ",conserved
R5042	T7679	T7680	nummod	one,functions
R5043	T7680	T7667	nsubjpass	functions,conserved
R5044	T7681	T7679	cc	or,one
R5045	T7682	T7679	conj	more,one
R5046	T7683	T7680	amod	essential,functions
R5047	T7684	T7680	prep	of,functions
R5048	T7685	T7686	det	this,protein
R5049	T7686	T7684	pobj	protein,of
R5050	T7687	T7667	aux	must,conserved
R5051	T7688	T7667	auxpass	be,conserved
R5052	T7689	T7667	punct	.,conserved
R5053	T7691	T7692	mark	Since,exhibit
R5054	T7692	T7696	advcl	exhibit,surmise
R5055	T7693	T7692	nsubj	TRIP13,exhibit
R5056	T7694	T7692	aux	does,exhibit
R5057	T7695	T7692	neg	not,exhibit
R5058	T7697	T7698	compound	checkpoint,function
R5059	T7698	T7692	dobj	function,exhibit
R5060	T7699	T7692	prep	in,exhibit
R5061	T7700	T7699	pobj	mice,in
R5062	T7701	T7696	punct	", ",surmise
R5063	T7702	T7696	nsubj	we,surmise
R5064	T7703	T7704	mark	that,had
R5065	T7704	T7696	ccomp	had,surmise
R5066	T7705	T7706	det	the,protein
R5067	T7706	T7704	nsubj	protein,had
R5068	T7707	T7708	nmod	TRIP13,PCH2
R5069	T7708	T7706	nmod	PCH2,protein
R5070	T7709	T7708	punct	/,PCH2
R5071	T7710	T7706	amod	ancestral,protein
R5072	T7711	T7712	det	a,function
R5073	T7712	T7704	dobj	function,had
R5074	T7713	T7712	prep	in,function
R5075	T7714	T7713	pobj	recombination,in
R5076	T7715	T7716	dep	that,persists
R5077	T7716	T7712	relcl	persists,function
R5078	T7717	T7716	prep	to,persists
R5079	T7718	T7719	det	the,present
R5080	T7719	T7717	pobj	present,to
R5081	T7720	T7696	punct	.,surmise
R5082	T7722	T7723	advmod	Notably,appear
R5083	T7724	T7723	punct	", ",appear
R5084	T7725	T7726	compound	A.,thaliana
R5085	T7726	T7723	nsubj	thaliana,appear
R5086	T7727	T7723	aux	does,appear
R5087	T7728	T7723	neg	not,appear
R5088	T7729	T7730	aux	to,have
R5089	T7730	T7723	xcomp	have,appear
R5090	T7731	T7732	det	a,activity
R5091	T7732	T7730	dobj	activity,have
R5092	T7733	T7734	amod	meiotic,checkpoint
R5093	T7734	T7732	compound	checkpoint,activity
R5094	T7735	T7736	dep	that,eliminates
R5095	T7736	T7732	relcl	eliminates,activity
R5096	T7737	T7738	compound	mutant,meiocytes
R5097	T7738	T7736	dobj	meiocytes,eliminates
R5098	T7739	T7736	prep	in,eliminates
R5099	T7740	T7741	det	a,manner
R5100	T7741	T7739	pobj	manner,in
R5101	T7742	T7741	amod	analogous,manner
R5102	T7743	T7742	prep	to,analogous
R5103	T7744	T7743	pobj	organisms,to
R5104	T7745	T7746	amod	such,as
R5105	T7746	T7744	prep	as,organisms
R5106	T7747	T7746	pobj	mice,as
R5107	T7748	T7747	punct	", ",mice
R5108	T7749	T7750	amod	budding,yeast
R5109	T7750	T7747	conj	yeast,mice
R5110	T7759	T7756	punct	],57
R5111	T7751	T7750	punct	", ",yeast
R5112	T7760	T7723	punct	", ",appear
R5113	T7752	T7750	cc	and,yeast
R5114	T7761	T7723	cc	and,appear
R5115	T7762	T7763	amod	mammalian,TRIP13
R5116	T7753	T7754	amod	female,Drosophila
R5117	T7763	T7764	nsubj	TRIP13,is
R5118	T7764	T7723	conj	is,appear
R5119	T7754	T7750	conj	Drosophila,yeast
R5120	T7765	T7766	advmod	more,similar
R5121	T7766	T7764	acomp	similar,is
R5122	T7755	T7756	punct	[,57
R5123	T7767	T7766	prep	to,similar
R5124	T7756	T7723	parataxis	57,appear
R5125	T7768	T7769	compound	Arabidopsis,PCH2
R5126	T7769	T7767	pobj	PCH2,to
R5127	T7757	T7756	nummod	11,57
R5128	T7770	T7766	prep	than,similar
R5129	T7771	T7772	det	the,proteins
R5130	T7772	T7770	pobj	proteins,than
R5131	T7773	T7772	nmod	fly,proteins
R5132	T7758	T7756	punct	",",57
R5133	T7774	T7773	cc	or,fly
R5134	T7775	T7773	conj	worm,fly
R5135	T7865	T7863	nsubjpass	functions,gained
R5136	T7776	T7777	punct	(,1A
R5137	T7777	T7764	parataxis	1A,is
R5138	T7778	T7777	compound	Figures,1A
R5139	T7779	T7777	cc	and,1A
R5140	T7780	T7777	conj	S1,1A
R5141	T7781	T7777	punct	),1A
R5142	T7866	T7865	prep	in,functions
R5143	T7782	T7723	punct	.,appear
R5144	T7867	T7866	pobj	PCH2,in
R5145	T7784	T7785	det	The,relatedness
R5146	T7785	T7787	nsubj	relatedness,be
R5147	T7786	T7785	amod	unusual,relatedness
R5148	T7868	T7863	auxpass	were,gained
R5149	T7788	T7785	prep	between,relatedness
R5150	T7869	T7863	cc	or,gained
R5151	T7789	T7790	amod	mammalian,PCH2
R5152	T7790	T7788	pobj	PCH2,between
R5153	T7870	T7863	conj	lost,gained
R5154	T7791	T7789	cc	and,mammalian
R5155	T7792	T7789	conj	plant,mammalian
R5156	T7793	T7787	aux	may,be
R5157	T7871	T7832	punct	.,allow
R5158	T7794	T7787	advmod	therefore,be
R5159	T7795	T7787	acomp	attributable,be
R5160	T7796	T7795	prep	to,attributable
R5161	T7873	T7874	nsubj	It,is
R5162	T7797	T7798	preconj	both,presence
R5163	T7798	T7796	pobj	presence,to
R5164	T7799	T7798	det	the,presence
R5165	T7875	T7874	acomp	possible,is
R5166	T7800	T7798	prep	of,presence
R5167	T7801	T7802	det	a,function
R5168	T7802	T7800	pobj	function,of
R5169	T7803	T7802	amod	common,function
R5170	T7804	T7802	amod	conserved,function
R5171	T7876	T7877	mark	that,evolved
R5172	T7805	T7806	punct	(,recombination
R5173	T7806	T7802	parataxis	recombination,function
R5174	T7877	T7874	ccomp	evolved,is
R5175	T7807	T7806	advmod	namely,recombination
R5176	T7808	T7806	punct	", ",recombination
R5177	T7809	T7810	mark	although,has
R5178	T7878	T7879	poss	its,function
R5179	T7810	T7806	advcl	has,recombination
R5180	T7811	T7812	det	the,role
R5181	T7812	T7810	nsubj	role,has
R5182	T7813	T7812	prep	of,role
R5183	T7814	T7813	pobj	PCH2,of
R5184	T7879	T7877	nsubj	function,evolved
R5185	T7815	T7812	prep	in,role
R5186	T7816	T7815	pobj	plants,in
R5187	T7817	T7818	advmod	yet,determined
R5188	T7880	T7879	compound	checkpoint,function
R5189	T7818	T7810	xcomp	determined,has
R5190	T7819	T7818	aux	to,determined
R5191	T7820	T7818	auxpass	be,determined
R5192	T7881	T7877	advmod	independently,evolved
R5193	T7821	T7810	punct	),has
R5194	T7822	T7798	punct	", ",presence
R5195	T7882	T7877	prep	in,evolved
R5196	T7823	T7798	cc	and,presence
R5197	T7824	T7825	det	the,absence
R5198	T7883	T7882	pobj	worms,in
R5199	T7825	T7798	conj	absence,presence
R5200	T7826	T7825	prep	of,absence
R5201	T7884	T7883	cc	and,worms
R5202	T7885	T7886	compound	budding,yeast
R5203	T7886	T7883	conj	yeast,worms
R5204	T7887	T7874	punct	.,is
R5205	T7827	T7828	compound	checkpoint,function
R5206	T7889	T7890	det	The,picture
R5207	T7828	T7826	pobj	function,of
R5208	T7829	T7787	punct	.,be
R5209	T7890	T7891	nsubj	picture,become
R5210	T7831	T7832	advmod	Nevertheless,allow
R5211	T7892	T7891	aux	will,become
R5212	T7833	T7832	punct	", ",allow
R5213	T7834	T7835	det	the,relationships
R5214	T7835	T7832	nsubj	relationships,allow
R5215	T7893	T7891	acomp	clearer,become
R5216	T7836	T7835	amod	evolutionary,relationships
R5217	T7837	T7835	prep	between,relationships
R5218	T7838	T7837	pobj	animals,between
R5219	T7894	T7895	mark	as,elucidated
R5220	T7839	T7838	punct	", ",animals
R5221	T7840	T7838	conj	fungi,animals
R5222	T7895	T7891	advcl	elucidated,become
R5223	T7841	T7840	punct	", ",fungi
R5224	T7842	T7840	cc	and,fungi
R5225	T7843	T7840	conj	plants,fungi
R5226	T7844	T7835	punct	(,relationships
R5227	T7896	T7897	det	the,function
R5228	T7845	T7846	dep	which,are
R5229	T7846	T7835	relcl	are,relationships
R5230	T7847	T7846	acomp	discordant,are
R5231	T7897	T7895	nsubjpass	function,elucidated
R5232	T7848	T7847	prep	with,discordant
R5233	T7849	T7850	compound	PCH2,phylogeny
R5234	T7898	T7897	prep	of,function
R5235	T7850	T7848	pobj	phylogeny,with
R5236	T7899	T7898	pobj	PCH2,of
R5237	T7851	T7850	compound	sequence,phylogeny
R5238	T7852	T7832	punct	),allow
R5239	T7900	T7897	prep	in,function
R5240	T7853	T7832	aux	do,allow
R5241	T7854	T7832	neg	not,allow
R5242	T7855	T7856	amod	parsimonious,models
R5243	T7901	T7902	amod	other,organisms
R5244	T7856	T7832	dobj	models,allow
R5245	T7857	T7856	acl	addressing,models
R5246	T7902	T7900	pobj	organisms,in
R5247	T7858	T7859	det	the,points
R5248	T7859	T7857	dobj	points,addressing
R5249	T7903	T7895	auxpass	is,elucidated
R5250	T7860	T7859	prep	in,points
R5251	T7861	T7860	pobj	time,in
R5252	T7904	T7891	punct	.,become
R5253	T7862	T7863	prep	that,gained
R5254	T7863	T7861	relcl	gained,time
R5255	T7864	T7865	compound	checkpoint,functions
R5256	T7906	T7907	det	The,nature
R5257	T7907	T7908	nsubj	nature,remains
R5258	T7909	T7907	prep	of,nature
R5259	T7910	T7911	det	the,checkpoint
R5260	T7971	T7970	prep	of,upstream
R5261	T7911	T7909	pobj	checkpoint,of
R5262	T7972	T7971	pobj	PCH2,of
R5263	T7973	T7967	punct	.,acts
R5264	T7912	T7911	compound	synapsis,checkpoint
R5265	T7975	T7976	prep	Given,is
R5266	T7977	T7978	mark	that,have
R5267	T7913	T7911	prep	in,checkpoint
R5268	T7978	T7975	pcomp	have,Given
R5269	T7979	T7978	nsubj	TRIP13,have
R5270	T7914	T7915	amod	male,mice
R5271	T7980	T7978	aux	does,have
R5272	T7981	T7978	neg	n't,have
R5273	T7915	T7913	pobj	mice,in
R5274	T7982	T7983	compound	checkpoint,function
R5275	T7983	T7978	dobj	function,have
R5276	T7984	T7978	prep	in,have
R5277	T7916	T7908	acomp	unidentified,remains
R5278	T7985	T7984	pobj	mice,in
R5279	T7986	T7976	punct	", ",is
R5280	T7917	T7908	punct	.,remains
R5281	T7987	T7988	det	a,role
R5282	T7988	T7976	nsubj	role,is
R5283	T7989	T7988	amod	potential,role
R5284	T7919	T7920	nummod	One,candidate
R5285	T7990	T7988	prep	for,role
R5286	T7920	T7922	nsubj	candidate,is
R5287	T7991	T7992	amod	mammalian,DOT1
R5288	T7921	T7920	amod	possible,candidate
R5289	T7992	T7990	pobj	DOT1,for
R5290	T7993	T7988	prep	in,role
R5291	T7923	T7922	attr	Dot1,is
R5292	T7994	T7995	det	the,checkpoint
R5293	T7995	T7993	pobj	checkpoint,in
R5294	T7996	T7995	compound	pachytene,checkpoint
R5295	T7924	T7923	punct	(,Dot1
R5296	T7997	T7976	acomp	dubious,is
R5297	T7998	T7976	cc	but,is
R5298	T7999	T7976	conj	awaits,is
R5299	T7925	T7923	appos	PCH1,Dot1
R5300	T8000	T7999	dobj	investigation,awaits
R5301	T8001	T7976	punct	.,is
R5302	T7926	T7925	prep	in,PCH1
R5303	T8003	T8004	advmod	Recently,shown
R5304	T7927	T7926	pobj	yeast,in
R5305	T8005	T8004	punct	", ",shown
R5306	T7928	T7923	punct	),Dot1
R5307	T8006	T8004	nsubjpass	it,shown
R5308	T8007	T8004	auxpass	was,shown
R5309	T8008	T8009	mark	that,required
R5310	T7929	T7923	punct	", ",Dot1
R5311	T8009	T8004	ccomp	required,shown
R5312	T8010	T8011	det	the,homolog
R5313	T8011	T8009	nsubjpass	homolog,required
R5314	T7930	T7931	det	a,factor
R5315	T8012	T8011	compound	TRP53,homolog
R5316	T8013	T8011	appos	TRP63,homolog
R5317	T7931	T7923	appos	factor,Dot1
R5318	T8014	T8009	auxpass	is,required
R5319	T8015	T8009	prep	for,required
R5320	T8016	T8017	compound	DNA,damage
R5321	T7932	T7933	compound	histone,methyltransferase
R5322	T8017	T8018	npadvmod	damage,induced
R5323	T8018	T8020	amod	induced,death
R5324	T8019	T8018	punct	–,induced
R5325	T7933	T7934	compound	methyltransferase,silencing
R5326	T8020	T8015	pobj	death,for
R5327	T7934	T7931	compound	silencing,factor
R5328	T8021	T8020	prep	of,death
R5329	T8022	T8023	nmod	dictyate,stage
R5330	T8023	T8025	nmod	stage,oocytes
R5331	T7935	T7936	dep	that,required
R5332	T8024	T8023	punct	-,stage
R5333	T7936	T7931	relcl	required,factor
R5334	T8025	T8021	pobj	oocytes,of
R5335	T7937	T7936	auxpass	is,required
R5336	T8026	T8025	amod	primordial,oocytes
R5337	T8027	T8009	punct	", ",required
R5338	T8028	T8009	advcl	leading,required
R5339	T8029	T8028	prep	to,leading
R5340	T8030	T8031	det	the,suggestion
R5341	T7938	T7936	prep	for,required
R5342	T7939	T7940	compound	pachytene,arrest
R5343	T8031	T8029	pobj	suggestion,to
R5344	T7940	T7938	pobj	arrest,for
R5345	T8032	T8033	mark	that,involved
R5346	T8033	T8031	acl	involved,suggestion
R5347	T8034	T8033	nsubjpass	it,involved
R5348	T7941	T7940	prep	of,arrest
R5349	T8035	T8033	auxpass	is,involved
R5350	T8036	T8033	prep	in,involved
R5351	T8037	T8036	pcomp	monitoring,in
R5352	T7942	T7943	nmod	zip1,mutants
R5353	T8038	T8039	compound	genome,integrity
R5354	T8039	T8037	dobj	integrity,monitoring
R5355	T7943	T7941	pobj	mutants,of
R5356	T8040	T8041	punct	[,59
R5357	T8041	T8009	parataxis	59,required
R5358	T8042	T8041	punct	],59
R5359	T7944	T7942	cc	and,zip1
R5360	T8043	T8004	punct	.,shown
R5361	T7945	T7942	conj	dmc1,zip1
R5362	T8045	T8046	advmod	However,occurs
R5363	T8047	T8046	punct	", ",occurs
R5364	T7946	T7940	prep	in,arrest
R5365	T8048	T8049	det	this,activity
R5366	T8049	T8046	nsubj	activity,occurs
R5367	T7947	T7946	pobj	yeast,in
R5368	T8050	T8046	advmod	subsequent,occurs
R5369	T8051	T8050	prep	to,subsequent
R5370	T8052	T8053	det	a,checkpoint
R5371	T7948	T7949	punct	[,58
R5372	T8053	T8051	pobj	checkpoint,to
R5373	T8054	T8053	compound	pachytene,checkpoint
R5374	T7949	T7940	parataxis	58,arrest
R5375	T8055	T8046	punct	.,occurs
R5376	T8057	T8058	mark	As,alluded
R5377	T7950	T7949	punct	],58
R5378	T8058	T8059	advcl	alluded,is
R5379	T8060	T8058	prep	to,alluded
R5380	T7951	T7938	punct	", ",for
R5381	T8061	T8058	advmod	earlier,alluded
R5382	T8062	T8059	punct	", ",is
R5383	T8063	T8064	det	a,problem
R5384	T7952	T7938	cc	and,for
R5385	T8064	T8059	nsubj	problem,is
R5386	T8065	T8064	amod	complicating,problem
R5387	T7953	T7938	conj	for,for
R5388	T8066	T8064	prep	for,problem
R5389	T8067	T8066	pcomp	studying,for
R5390	T8068	T8069	amod	potential,checkpoint
R5391	T8069	T8071	compound	checkpoint,genes
R5392	T8070	T8069	amod	meiotic,checkpoint
R5393	T8071	T8067	dobj	genes,studying
R5394	T7954	T7953	pcomp	preventing,for
R5395	T8072	T8067	prep	in,studying
R5396	T8073	T8072	pobj	mice,in
R5397	T8074	T8075	mark	that,have
R5398	T7955	T7956	npadvmod	RAD54,mediated
R5399	T8075	T8059	ccomp	have,is
R5400	T8076	T8075	prep	as,have
R5401	T7956	T7958	amod	mediated,repair
R5402	T7957	T7956	punct	-,mediated
R5403	T7958	T7954	dobj	repair,preventing
R5404	T7959	T7960	amod	recombinational,DSB
R5405	T8077	T8076	prep	in,as
R5406	T7960	T7958	compound	DSB,repair
R5407	T8078	T8077	pobj	yeast,in
R5408	T8079	T8075	punct	", ",have
R5409	T7961	T7958	prep	between,repair
R5410	T8080	T8081	amod	such,genes
R5411	T8081	T8075	nsubj	genes,have
R5412	T8082	T8075	advmod	often,have
R5413	T7962	T7963	compound	sister,chromatids
R5414	T8083	T8084	amod	mitotic,functions
R5415	T8084	T8075	dobj	functions,have
R5416	T7963	T7961	pobj	chromatids,between
R5417	T8085	T8084	punct	(,functions
R5418	T8086	T8087	amod	such,as
R5419	T7964	T7922	punct	.,is
R5420	T8087	T8084	prep	as,functions
R5421	T8088	T8087	pobj	RAD24,as
R5422	T7966	T7967	advmod	However,acts
R5423	T8089	T8090	punct	[,7
R5424	T8090	T8075	parataxis	7,have
R5425	T8091	T8090	punct	],7
R5426	T8092	T8059	punct	),is
R5427	T7968	T7967	punct	", ",acts
R5428	T8093	T8059	punct	", ",is
R5429	T8094	T8059	cc	and,is
R5430	T8095	T8096	poss	their,ablation
R5431	T8096	T8097	nsubj	ablation,cause
R5432	T7969	T7967	nsubj	DOT1,acts
R5433	T8097	T8059	conj	cause,is
R5434	T8098	T8097	aux	can,cause
R5435	T8099	T8097	dobj	lethality,cause
R5436	T7970	T7967	advmod	upstream,acts
R5437	T8100	T8101	punct	[,42
R5438	T8101	T8097	parataxis	42,cause
R5439	T8102	T8101	punct	],42
R5440	T8103	T8097	punct	.,cause
R5441	T8105	T8106	mark	Unless,have
R5442	T8106	T8111	advcl	have,are
R5443	T8107	T8108	amod	mammalian,components
R5444	T8108	T8106	nsubj	components,have
R5445	T8109	T8110	compound	pachytene,checkpoint
R5446	T8110	T8108	compound	checkpoint,components
R5447	T8112	T8106	dobj	orthologs,have
R5448	T8113	T8112	prep	with,orthologs
R5449	T8114	T8115	amod	similar,functions
R5450	T8115	T8113	pobj	functions,with
R5451	T8116	T8106	prep	in,have
R5452	T8117	T8116	pobj	organisms,in
R5453	T8118	T8119	amod	such,as
R5454	T8119	T8117	prep	as,organisms
R5455	T8120	T8119	pobj	yeast,as
R5456	T8121	T8111	punct	", ",are
R5457	T8122	T8123	poss	their,identities
R5458	T8123	T8111	nsubj	identities,are
R5459	T8124	T8111	acomp	likely,are
R5460	T8125	T8126	aux	to,remain
R5461	T8126	T8124	xcomp	remain,likely
R5462	T8127	T8126	acomp	elusive,remain
R5463	T8128	T8111	punct	.,are

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T5977	11-18	SO:0000704	denotes	Genetic
T5978	34-47	NCBITaxon:4932	denotes	S. cerevisiae
T5979	75-95	GO:0051598	denotes	pachytene checkpoint
T5980	96-104	GO:0065007	denotes	monitors
T5981	121-136	_FRAGMENT	denotes	recombinational
T5982	141-147	GO:0000725	denotes	repair
T5983	137-147	GO:0006302	denotes	DSB repair
T5984	152-160	GO:0007129	denotes	synapsis
T5985	210-227	GO:0000077	denotes	repair checkpoint
T5986	231-236	PR:000013665	denotes	RAD17
T5987	237-241	PR:P46946	denotes	SAE2
T5988	263-271	GO:0007129	denotes	synapsis
T5989	272-282	GO:0000075	denotes	checkpoint
T5990	286-290	PR:P38126	denotes	PCH2
T5991	291-295	PR:P31111	denotes	ZIP1
T5992	326-331	SO:0000704	denotes	genes
T5993	333-337	PR:P46946	denotes	SAE2
T5994	342-346	PR:P31111	denotes	ZIP1
T5995	365-374	NCBITaxon:40674	denotes	mammalian
T5996	375-384	SO:0000855	denotes	orthologs
T5997	395-400	PR:000015862	denotes	SYCP1
T5998	421-429	SO:0000855	denotes	ortholog
T5999	433-437	PR:P31111	denotes	ZIP1
T6000	460-465	NCBITaxon:10088	denotes	mouse
T6001	466-471	PR:000013665	denotes	RAD17
T6002	472-480	SO:0000855	denotes	ortholog
T6003	482-486	PR:P06777	denotes	Rad1
T6004	506-515	UBERON:0000922	denotes	embryonic
T6005	561-566	NCBITaxon:10088	denotes	mouse
T6006	567-571	PR:P38126	denotes	Pch2
T6007	573-579	PR:000016672	denotes	Trip13
T6008	613-621	GO:0007129	denotes	synapsis
T6009	622-632	GO:0000075	denotes	checkpoint
T6010	636-646	NCBITaxon:6239	denotes	C. elegans
T6011	731-740	NCBITaxon:40674	denotes	mammalian
T6012	741-759	GO:0033313	denotes	meiotic checkpoint
T6013	760-767	GO:0065007	denotes	control
T6014	801-805	NCBITaxon:10088	denotes	mice
T6015	819-826	GO:0007126	denotes	meiotic
T6016	839-845	PR:000016672	denotes	TRIP13
T6017	918-938	GO:0051598	denotes	pachytene checkpoint
T6018	939-946	GO:0065007	denotes	control
T6019	1024-1027	GO:0035825	denotes	COs
T6020	1052-1058	PR:000016672	denotes	Trip13
T6021	1092-1098	GO:0006302	denotes	repair
T6022	1217-1224	GO:0007126	denotes	meiotic
T6023	1252-1265	NCBITaxon:4932	denotes	S. cerevisiae
T6024	1267-1269	GO:0035825	denotes	CO
T6025	1406-1410	NCBITaxon:10088	denotes	Mice
T6026	1443-1445	_FRAGMENT	denotes	CO
T6027	1457-1470	GO:0007131	denotes	recombination
T6028	1512-1517	PR:000015553	denotes	SPO11
T6029	1526-1532	MOP:0000780	denotes	breaks
T6030	1547-1549	GO:0035825	denotes	CO
T6031	1567-1571	PR:000010442	denotes	MLH1
T6032	1631-1640	GO:0000239	denotes	pachynema
T6033	1771-1781	GO:0006302	denotes	DSB repair
T6034	1799-1806	GO:0007126	denotes	meiotic
T6035	1826-1831	PR:000013680	denotes	RAD54
T6036	1915-1922	GO:0007126	denotes	meiosis
T6037	1942-1946	NCBITaxon:10088	denotes	mice
T6038	1971-1976	PR:000013680	denotes	RAD54
T6039	1987-2000	CL:0000017	denotes	spermatocytes
T6040	2033-2038	PR:000013672	denotes	RAD51
T6041	2047-2056	GO:0000239	denotes	pachytene
T6042	2090-2096	PR:000016672	denotes	TRIP13
T6043	2097-2101	NCBITaxon:10088	denotes	mice
T6044	2143-2150	GO:0007126	denotes	meiotic
T6045	2192-2199	GO:0007114	denotes	budding
T6046	2192-2205	NCBITaxon:4892	denotes	budding yeast
T6047	2271-2275	PR:P38126	denotes	PCH2
T6048	2283-2290	GO:0007126	denotes	meiotic
T6049	2356-2371	GO:0075317	denotes	ascus formation
T6050	2582-2591	GO:0007127	denotes	meiosis I
T6051	2615-2620	PR:000013665	denotes	RAD17
T6052	2621-2625	PR:P46946	denotes	SAE2
T6053	2626-2636	GO:0000075	denotes	checkpoint
T6054	2642-2650	GO:0065007	denotes	monitors
T6055	2712-2718	PR:000016672	denotes	TRIP13
T6056	2723-2727	PR:P38126	denotes	Pch2
T6057	2766-2774	GO:0007129	denotes	synapsis
T6058	2785-2791	PR:000016672	denotes	TRIP13
T6059	2802-2815	CL:0000017	denotes	spermatocytes
T6060	2863-2868	PR:000015553	denotes	SPO11
T6061	2873-2877	PR:000031227	denotes	MEI1
T6062	2896-2902	PR:000016672	denotes	TRIP13
T6063	3004-3006	GO:0035825	denotes	CO
T6064	3007-3013	GO:0006281	denotes	repair
T6065	3065-3067	CHEBI:44658	denotes	OA
T6066	3131-3137	PR:000016672	denotes	TRIP13
T6067	3291-3297	PR:000016672	denotes	TRIP13
T6068	3314-3328	_FRAGMENT	denotes	disassembly of
T6069	3356-3365	GO:0032984	denotes	complexes
T6070	3333-3355	GO:0000725	denotes	recombinational repair
T6071	3356-3365	GO:0032991	denotes	complexes
T6072	3424-3430	PR:000016672	denotes	Trip13
T6073	3436-3445	GO:0000239	denotes	pachytene
T6074	3468-3474	PR:000016672	denotes	TRIP13
T6075	3499-3506	SO:0000417	denotes	domains
T6076	3534-3538	PR:000022296	denotes	ClpA
T6077	3565-3572	_FRAGMENT	denotes	protein
T6078	3588-3607	GO:0043241	denotes	complex disassembly
T6079	3576-3595	GO:0032993	denotes	protein/DNA complex
T6080	3576-3607	GO:0032986	denotes	protein/DNA complex disassembly
T6081	3674-3681	GO:0007126	denotes	meiosis
T6082	3689-3695	PR:000016672	denotes	Trip13
T6083	3733-3740	NCBITaxon:33208	denotes	animals
T6084	3783-3789	PR:000016672	denotes	TRIP13
T6085	3916-3923	GO:0007126	denotes	meiosis
T6086	3948-3958	GO:0008219	denotes	cell death
T6087	3962-3968	PR:000016672	denotes	Trip13
T6088	4032-4042	GO:0006302	denotes	DSB repair
T6089	4056-4064	GO:0007129	denotes	synapsis
T6090	4115-4121	CL:0000023	denotes	oocyte
T6091	4174-4182	GO:0007129	denotes	synapsis
T6092	4196-4209	CL:0000017	denotes	spermatocytes
T6093	4213-4218	UBERON:0007023	denotes	adult
T6094	4219-4225	UBERON:0000473	denotes	testes
T6095	4312-4320	GO:0007129	denotes	synapsis
T6096	4334-4338	PR:000006536	denotes	Dmc1
T6097	4361-4367	PR:000016672	denotes	Trip13
T6098	4410-4418	GO:0006281	denotes	repaired
T6099	4452-4461	NCBITaxon:40674	denotes	mammalian
T6100	4462-4482	GO:0051598	denotes	pachytene checkpoint
T6101	4544-4551	CL:0000023	denotes	oocytes
T6102	4556-4569	CL:0000017	denotes	spermatocytes
T6103	4605-4615	_FRAGMENT	denotes	DNA damage
T6104	4626-4636	GO:0000077	denotes	checkpoint
T6105	4616-4636	GO:0051598	denotes	pachytene checkpoint
T6106	4662-4670	GO:0007129	denotes	synapsis
T6107	4671-4681	GO:0000075	denotes	checkpoint
T6108	4712-4714	CHEBI:44658	denotes	OA
T6109	4728-4734	PR:000016672	denotes	Trip13
T6110	4740-4753	CL:0000017	denotes	spermatocytes
T6111	4777-4779	GO:0007132	denotes	MI
T6112	4841-4850	GO:0000239	denotes	pachytene
T6113	4851-4864	CL:0000017	denotes	spermatocytes
T6114	4926-4935	CHEBI:4911	denotes	etoposide
T6115	4995-5004	GO:0000239	denotes	pachynema
T6116	5014-5024	GO:0000075	denotes	checkpoint
T6117	5061-5063	CHEBI:44658	denotes	OA
T6118	5082-5097	GO:0042148	denotes	strand invasion
T6119	5109-5115	PR:000016672	denotes	TRIP13
T6120	5126-5139	CL:0000017	denotes	spermatocytes
T6121	5148-5154	PR:000016672	denotes	TRIP13
T6122	5206-5209	NCBITaxon:10114	denotes	rat
T6123	5210-5217	UBERON:0002046	denotes	thyroid
T6124	5210-5231	PR:000016321	denotes	thyroid receptor beta
T6125	5233-5237	PR:000016321	denotes	THRB
T6126	5275-5279	PR:000016321	denotes	THRB
T6127	5284-5290	PR:000016672	denotes	TRIP13
T6128	5294-5301	GO:0007126	denotes	meiosis
T6129	5346-5350	PR:000016321	denotes	THRB
T6130	5397-5409	CL:0000017	denotes	spermatocyte
T6131	5410-5416	GO:0005634	denotes	nuclei
T6132	5442-5444	_FRAGMENT	denotes	XY
T6133	5451-5455	GO:0001741	denotes	body
T6134	5446-5449	_FRAGMENT	denotes	sex
T6135	5504-5511	GO:0005634	denotes	nuclear
T6136	5532-5541	GO:0000239	denotes	pachynema
T6137	5556-5571	GO:0000803	denotes	sex chromosomes
T6138	5579-5598	GO:0031507	denotes	heterochromatinized
T6139	5603-5629	GO:0006342	denotes	transcriptionally silenced
T6140	5672-5679	GO:0001741	denotes	XY body
T6141	5711-5724	CL:0000017	denotes	spermatocytes
T6142	5762-5764	GO:0001741	denotes	XY
T6143	5765-5787	GO:0031507	denotes	heterochromatinization
T6144	5833-5837	PR:000016321	denotes	THRB
T6145	5847-5851	NCBITaxon:10088	denotes	mice
T6146	5917-5923	PR:000016672	denotes	TRIP13
T6147	5941-5945	PR:000016321	denotes	THRB
T6148	5949-5956	GO:0007126	denotes	meiosis
T6149	5998-6002	PR:P38126	denotes	PCH2
T6150	6003-6012	SO:0000855	denotes	orthologs
T6151	6028-6038	NCBITaxon:2759	denotes	eukaryotic
T6152	6119-6125	PR:000016672	denotes	TRIP13
T6153	6143-6153	GO:0000075	denotes	checkpoint
T6154	6166-6170	NCBITaxon:10088	denotes	mice
T6155	6192-6198	PR:000016672	denotes	TRIP13
T6156	6199-6203	PR:P38126	denotes	PCH2
T6157	6293-6304	NCBITaxon:3702	denotes	A. thaliana
T6158	6331-6349	GO:0033313	denotes	meiotic checkpoint
T6159	6417-6426	NCBITaxon:1	denotes	organisms
T6173	6786-6792	NCBITaxon:3193	denotes	plants
T6174	6839-6849	GO:0000075	denotes	checkpoint
T6175	6913-6920	NCBITaxon:33208	denotes	animals
T6176	6922-6927	NCBITaxon:4751	denotes	fungi
T6177	6933-6939	NCBITaxon:3193	denotes	plants
T6178	6967-6971	PR:P38126	denotes	PCH2
T6179	7060-7070	GO:0000075	denotes	checkpoint
T6180	7084-7088	PR:P38126	denotes	PCH2
T6181	7134-7144	GO:0000075	denotes	checkpoint
T6182	7189-7196	GO:0007114	denotes	budding
T6183	7189-7202	NCBITaxon:4892	denotes	budding yeast
T6184	7255-7259	PR:P38126	denotes	PCH2
T6185	7269-7278	NCBITaxon:1	denotes	organisms
T6186	7312-7320	GO:0007129	denotes	synapsis
T6187	7321-7331	GO:0000075	denotes	checkpoint
T6188	7340-7344	NCBITaxon:10088	denotes	mice
T6189	7393-7397	PR:Q9SIH2	denotes	Dot1
T6190	7399-7403	PR:Q04089	denotes	PCH1
T6191	7417-7424	PR:000043452	denotes	histone
T6192	7417-7424	CHEBI:15358	denotes	histone
T6193	7443-7452	GO:0016458	denotes	silencing
T6194	7481-7490	GO:0000239	denotes	pachytene
T6195	7501-7505	PR:P31111	denotes	zip1
T6196	7510-7514	PR:000006536	denotes	dmc1
T6197	7557-7562	PR:000013680	denotes	RAD54
T6198	7572-7587	_FRAGMENT	denotes	recombinational
T6199	7592-7598	GO:0000725	denotes	repair
T6200	7588-7598	GO:0006302	denotes	DSB repair
T6201	7635-7639	PR:Q9SIH2	denotes	DOT1
T6202	7657-7661	PR:P38126	denotes	PCH2
T6203	7674-7680	PR:000016672	denotes	TRIP13
T6204	7694-7704	GO:0000075	denotes	checkpoint
T6205	7717-7721	NCBITaxon:10088	denotes	mice
T6206	7744-7753	NCBITaxon:40674	denotes	mammalian
T6207	7754-7758	PR:Q9SIH2	denotes	DOT1
T6208	7766-7786	GO:0051598	denotes	pachytene checkpoint
T6209	7856-7861	PR:000003035	denotes	TRP53
T6210	7862-7869	SO:0000853	denotes	homolog
T6211	7870-7875	PR:000016567	denotes	TRP63
T6212	7911-7916	GO:0016265	denotes	death
T6213	7935-7953	CL:0000654	denotes	primordial oocytes
T6214	8004-8014	GO:0065007	denotes	monitoring
T6215	8015-8021	SO:0001026	denotes	genome
T6216	8084-8104	GO:0051598	denotes	pachytene checkpoint
T6217	8175-8193	GO:0033313	denotes	meiotic checkpoint
T6218	8194-8199	SO:0000704	denotes	genes
T6219	8203-8207	NCBITaxon:10088	denotes	mice
T6220	8234-8239	SO:0000704	denotes	genes
T6221	8251-8258	GO:0007067	denotes	mitotic
T6222	8278-8283	PR:P32641	denotes	RAD24
T6223	8342-8351	NCBITaxon:40674	denotes	mammalian
T6224	8352-8372	GO:0051598	denotes	pachytene checkpoint
T6225	8389-8398	SO:0000855	denotes	orthologs
T6226	8425-8434	NCBITaxon:1	denotes	organisms
T6160	6435-6439	NCBITaxon:10088	denotes	mice
T6161	6441-6448	GO:0007114	denotes	budding
T6162	6441-6454	NCBITaxon:4892	denotes	budding yeast
T6163	6467-6477	NCBITaxon:7215	denotes	Drosophila
T6164	6491-6500	NCBITaxon:40674	denotes	mammalian
T6165	6501-6507	PR:000016672	denotes	TRIP13
T6166	6527-6538	NCBITaxon:3701	denotes	Arabidopsis
T6167	6539-6543	PR:P38126	denotes	PCH2
T6168	6553-6556	NCBITaxon:7147	denotes	fly
T6169	6627-6636	NCBITaxon:40674	denotes	mammalian
T6170	6641-6646	NCBITaxon:3193	denotes	plant
T6171	6647-6651	PR:P38126	denotes	PCH2
T6172	6778-6782	PR:P38126	denotes	PCH2
R3989	T5982	T5981	_lexicallyChainedTo	repair,recombinational
R3990	T6027	T6026	_lexicallyChainedTo	recombination,CO
R3991	T6069	T6068	_lexicallyChainedTo	complexes,disassembly of
R3992	T6078	T6077	_lexicallyChainedTo	complex disassembly,protein
R3993	T6104	T6103	_lexicallyChainedTo	checkpoint,DNA damage
R3994	T6133	T6132	_lexicallyChainedTo	body,XY
R3995	T6133	T6134	_lexicallyChainedTo	body,sex
R3996	T6199	T6198	_lexicallyChainedTo	repair,recombinational

2_test

Id	Subject	Object	Predicate	Lexical cue
17696610-17174924-85497932	307-309	17174924	denotes	12
17696610-15297881-85497933	527-529	15297881	denotes	42
17696610-16339446-85497934	648-649	16339446	denotes	2
17696610-11461701-85497935	1301-1303	11461701	denotes	43
17696610-11461702-85497936	1398-1400	11461702	denotes	44
17696610-15066280-85497937	1401-1403	15066280	denotes	45
17696610-16307920-85497938	1481-1483	16307920	denotes	46
17696610-9409820-85497939	1948-1950	9409820	denotes	47
17696610-10228176-85497940	1951-1953	10228176	denotes	48
17696610-16428451-85497941	2177-2179	16428451	denotes	49
17696610-11779793-85497942	2373-2375	11779793	denotes	50
17696610-16179256-85497943	2524-2526	16179256	denotes	10
17696610-17174924-85497944	2680-2682	17174924	denotes	12
17696610-16980577-85497945	3367-3369	16980577	denotes	51
17696610-9927482-85497946	3609-3611	9927482	denotes	52
17696610-16700071-85497947	4937-4939	16700071	denotes	53
17696610-7776974-85497948	5240-5242	7776974	denotes	54
17696610-15120994-85497949	5654-5656	15120994	denotes	55
17696610-8670802-85497950	5876-5878	8670802	denotes	56
17696610-12456752-85497951	6479-6481	12456752	denotes	11
17696610-12782723-85497952	6482-6484	12782723	denotes	57
17696610-11029058-85497953	7533-7535	11029058	denotes	58
17696610-17122775-85497954	8033-8035	17122775	denotes	59
17696610-8893012-85497955	8285-8286	8893012	denotes	7
17696610-15297881-85497956	8330-8332	15297881	denotes	42
T31002	307-309	17174924	denotes	12
T20162	527-529	15297881	denotes	42
T99422	648-649	16339446	denotes	2
T99514	1301-1303	11461701	denotes	43
T99400	1398-1400	11461702	denotes	44
T37763	1401-1403	15066280	denotes	45
T86939	1481-1483	16307920	denotes	46
T49986	1948-1950	9409820	denotes	47
T30486	1951-1953	10228176	denotes	48
T82285	2177-2179	16428451	denotes	49
T96944	2373-2375	11779793	denotes	50
T31293	2524-2526	16179256	denotes	10
T35970	2680-2682	17174924	denotes	12
T91810	3367-3369	16980577	denotes	51
T43287	3609-3611	9927482	denotes	52
T49263	4937-4939	16700071	denotes	53
T95418	5240-5242	7776974	denotes	54
T5715	5654-5656	15120994	denotes	55
T32476	5876-5878	8670802	denotes	56
T49716	6479-6481	12456752	denotes	11
T61174	6482-6484	12782723	denotes	57
T54062	7533-7535	11029058	denotes	58
T11603	8033-8035	17122775	denotes	59
T92230	8285-8286	8893012	denotes	7
T50789	8330-8332	15297881	denotes	42

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T6227	11-18	SO_EXT:0000704	denotes	Genetic
T6228	34-47	NCBITaxon:4932	denotes	S. cerevisiae
T6229	75-95	GO:0051598	denotes	pachytene checkpoint
T6230	96-104	GO:0065007	denotes	monitors
T6231	109-117	GO_EXT:reaction_or_response	denotes	responds
T6232	121-136	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinational
T6233	121-136	_FRAGMENT	denotes	recombinational
T6234	141-147	GO:0000725	denotes	repair
T6235	137-147	GO:0006302	denotes	DSB repair
T6236	152-160	GO:0007129	denotes	synapsis
T6237	210-227	GO:0000077	denotes	repair checkpoint
T6238	231-236	PR_EXT:000013665	denotes	RAD17
T6239	237-241	PR_EXT:P46946	denotes	SAE2
T6240	263-271	GO:0007129	denotes	synapsis
T6241	272-282	GO:0000075	denotes	checkpoint
T6242	286-290	PR_EXT:P38126	denotes	PCH2
T6243	291-295	PR_EXT:P31111	denotes	ZIP1
T6244	326-331	SO_EXT:0000704	denotes	genes
T6245	333-337	PR_EXT:P46946	denotes	SAE2
T6246	342-346	PR_EXT:P31111	denotes	ZIP1
T6247	365-374	NCBITaxon:40674	denotes	mammalian
T6248	375-384	SO_EXT:0000855	denotes	orthologs
T6249	395-400	PR_EXT:000015862	denotes	SYCP1
T6250	421-429	SO_EXT:0000855	denotes	ortholog
T6251	433-437	PR_EXT:P31111	denotes	ZIP1
T6252	444-452	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T6253	460-465	NCBITaxon:10088	denotes	mouse
T6254	466-471	PR_EXT:000013665	denotes	RAD17
T6255	472-480	SO_EXT:0000855	denotes	ortholog
T6256	482-486	PR_EXT:P06777	denotes	Rad1
T6257	506-515	UBERON:0000922	denotes	embryonic
T6258	516-525	GO_EXT:fatality_or_lethality	denotes	lethality
T6259	538-548	SO_EXT:sequence_alteration_entity_or_process	denotes	mutational
T6260	561-566	NCBITaxon:10088	denotes	mouse
T6261	567-571	PR_EXT:P38126	denotes	Pch2
T6262	573-579	PR_EXT:000016672	denotes	Trip13
T6263	613-621	GO:0007129	denotes	synapsis
T6264	622-632	GO:0000075	denotes	checkpoint
T6265	636-646	NCBITaxon:6239	denotes	C. elegans
T6266	715-727	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T6267	731-740	NCBITaxon:40674	denotes	mammalian
T6268	741-759	GO:0033313	denotes	meiotic checkpoint
T6269	760-767	GO:0065007	denotes	control
T6270	801-805	NCBITaxon:10088	denotes	mice
T6271	819-826	GO:0007126	denotes	meiotic
T6272	839-845	PR_EXT:000016672	denotes	TRIP13
T6273	852-865	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6274	918-938	GO:0051598	denotes	pachytene checkpoint
T6275	939-946	GO:0065007	denotes	control
T6276	976-989	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6277	1024-1027	GO:0035825	denotes	COs
T6278	1052-1058	PR_EXT:000016672	denotes	Trip13
T6279	1059-1066	SO_EXT:sequence_altered_entity	denotes	mutants
T6280	1092-1098	GO:0006302	denotes	repair
T6281	1217-1224	GO:0007126	denotes	meiotic
T6282	1225-1238	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6283	1252-1265	NCBITaxon:4932	denotes	S. cerevisiae
T6284	1267-1269	GO:0035825	denotes	CO
T6285	1326-1339	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6286	1388-1396	CHEBI_PR_EXT:protein	denotes	proteins
T6287	1406-1410	NCBITaxon:10088	denotes	Mice
T6288	1443-1445	_FRAGMENT	denotes	CO
T6289	1457-1470	GO:0007131	denotes	recombination
T6290	1457-1470	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6291	1492-1497	NCBITaxon_EXT:yeast	denotes	yeast
T6292	1512-1517	PR_EXT:000015553	denotes	SPO11
T6293	1526-1532	MOP:0000780	denotes	breaks
T6294	1547-1549	GO:0035825	denotes	CO
T6295	1567-1571	PR_EXT:000010442	denotes	MLH1
T6296	1587-1598	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T6297	1631-1640	GO:0000239	denotes	pachynema
T6298	1674-1687	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6299	1734-1747	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6300	1771-1781	GO:0006302	denotes	DSB repair
T6301	1799-1806	GO:0007126	denotes	meiotic
T6302	1807-1812	CL_GO_EXT:cell	denotes	cells
T6303	1826-1831	PR_EXT:000013680	denotes	RAD54
T6304	1860-1873	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6305	1877-1882	NCBITaxon_EXT:yeast	denotes	yeast
T6306	1915-1922	GO:0007126	denotes	meiosis
T6307	1933-1938	NCBITaxon_EXT:yeast	denotes	yeast
T6308	1942-1946	NCBITaxon:10088	denotes	mice
T6309	1971-1976	PR_EXT:000013680	denotes	RAD54
T6310	1987-2000	CL:0000017	denotes	spermatocytes
T6311	2033-2038	PR_EXT:000013672	denotes	RAD51
T6312	2047-2056	GO:0000239	denotes	pachytene
T6313	2057-2068	GO_SO_EXT:chromosome	denotes	chromosomes
T6314	2090-2096	PR_EXT:000016672	denotes	TRIP13
T6315	2097-2101	NCBITaxon:10088	denotes	mice
T6316	2143-2150	GO:0007126	denotes	meiotic
T6317	2192-2199	GO:0007114	denotes	budding
T6318	2192-2205	NCBITaxon:4892	denotes	budding yeast
T6319	2244-2257	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6320	2259-2267	SO_EXT:sequence_deletion_entity_or_process	denotes	Deletion
T6321	2271-2275	PR_EXT:P38126	denotes	PCH2
T6322	2283-2290	GO:0007126	denotes	meiotic
T6323	2318-2323	NCBITaxon_EXT:yeast	denotes	yeast
T6324	2356-2371	GO:0075317	denotes	ascus formation
T6325	2412-2417	NCBITaxon_EXT:yeast	denotes	yeast
T6326	2426-2435	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T6327	2486-2493	SO_EXT:sequence_altered_entity	denotes	mutants
T6328	2517-2522	CL_GO_EXT:cell	denotes	cells
T6329	2570-2575	NCBITaxon_EXT:yeast	denotes	yeast
T6330	2582-2591	GO:0007127	denotes	meiosis I
T6331	2615-2620	PR_EXT:000013665	denotes	RAD17
T6332	2621-2625	PR_EXT:P46946	denotes	SAE2
T6333	2626-2636	GO:0000075	denotes	checkpoint
T6334	2642-2650	GO:0065007	denotes	monitors
T6335	2651-2664	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6336	2712-2718	PR_EXT:000016672	denotes	TRIP13
T6337	2723-2727	PR_EXT:P38126	denotes	Pch2
T6338	2732-2745	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6339	2766-2774	GO:0007129	denotes	synapsis
T6340	2785-2791	PR_EXT:000016672	denotes	TRIP13
T6341	2802-2815	CL:0000017	denotes	spermatocytes
T6342	2863-2868	PR_EXT:000015553	denotes	SPO11
T6343	2873-2877	PR_EXT:000031227	denotes	MEI1
T6344	2896-2902	PR_EXT:000016672	denotes	TRIP13
T6345	2951-2959	SO_EXT:sequence_substitution_process	denotes	exchange
T6346	2970-2983	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6347	3004-3006	GO:0035825	denotes	CO
T6348	3007-3013	GO:0006281	denotes	repair
T6349	3065-3067	CHEBI:44658	denotes	OA
T6350	3097-3108	GO_SO_EXT:chromosome	denotes	chromosomes
T6351	3131-3137	PR_EXT:000016672	denotes	TRIP13
T6352	3148-3161	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6353	3234-3247	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6354	3291-3297	PR_EXT:000016672	denotes	TRIP13
T6355	3314-3328	_FRAGMENT	denotes	disassembly of
T6356	3356-3365	GO:0032984	denotes	complexes
T6357	3333-3348	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinational
T6358	3333-3355	GO:0000725	denotes	recombinational repair
T6359	3356-3365	GO:0032991	denotes	complexes
T6360	3388-3396	CHEBI_PR_EXT:protein	denotes	proteins
T6361	3424-3430	PR_EXT:000016672	denotes	Trip13
T6362	3436-3445	GO:0000239	denotes	pachytene
T6363	3446-3457	GO_SO_EXT:chromosome	denotes	chromosomes
T6364	3468-3474	PR_EXT:000016672	denotes	TRIP13
T6365	3492-3498	GO_EXT:0016887	denotes	ATPase
T6366	3499-3506	SO_EXT:0000417	denotes	domains
T6367	3527-3533	GO_EXT:0016887	denotes	ATPase
T6368	3534-3538	PR_EXT:000022296	denotes	ClpA
T6369	3565-3572	CHEBI_PR_EXT:protein	denotes	protein
T6370	3565-3572	_FRAGMENT	denotes	protein
T6371	3588-3607	GO:0043241	denotes	complex disassembly
T6372	3576-3583	CHEBI_PR_EXT:protein	denotes	protein
T6373	3576-3595	GO:0032993	denotes	protein/DNA complex
T6374	3576-3607	GO:0032986	denotes	protein/DNA complex disassembly
T6375	3584-3587	CHEBI_SO_EXT:DNA	denotes	DNA
T6376	3630-3643	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6377	3674-3681	GO:0007126	denotes	meiosis
T6378	3689-3695	PR_EXT:000016672	denotes	Trip13
T6379	3706-3717	GO_EXT:transcription	denotes	transcribed
T6380	3726-3732	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T6381	3733-3740	NCBITaxon:33208	denotes	animals
T6382	3783-3789	PR_EXT:000016672	denotes	TRIP13
T6383	3916-3923	GO:0007126	denotes	meiosis
T6384	3948-3952	CL_GO_EXT:cell	denotes	cell
T6385	3948-3958	GO:0008219	denotes	cell death
T6386	3962-3968	PR_EXT:000016672	denotes	Trip13
T6387	3969-3976	SO_EXT:sequence_altered_entity	denotes	mutants
T6388	4032-4042	GO:0006302	denotes	DSB repair
T6389	4056-4064	GO:0007129	denotes	synapsis
T6390	4115-4121	CL:0000023	denotes	oocyte
T6391	4122-4133	GO_EXT:killing	denotes	elimination
T6392	4174-4182	GO:0007129	denotes	synapsis
T6393	4196-4209	CL:0000017	denotes	spermatocytes
T6394	4213-4218	UBERON:0007023	denotes	adult
T6395	4219-4225	UBERON:0000473	denotes	testes
T6396	4240-4246	SO_EXT:sequence_altered_entity	denotes	mutant
T6397	4265-4278	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6398	4312-4320	GO:0007129	denotes	synapsis
T6399	4334-4338	PR_EXT:000006536	denotes	Dmc1
T6400	4361-4367	PR_EXT:000016672	denotes	Trip13
T6401	4368-4374	SO_EXT:sequence_altered_entity	denotes	mutant
T6402	4410-4418	GO:0006281	denotes	repaired
T6403	4419-4422	CHEBI_SO_EXT:DNA	denotes	DNA
T6404	4452-4461	NCBITaxon:40674	denotes	mammalian
T6405	4462-4482	GO:0051598	denotes	pachytene checkpoint
T6406	4483-4491	GO_EXT:reaction_or_response	denotes	response
T6407	4544-4551	CL:0000023	denotes	oocytes
T6408	4556-4569	CL:0000017	denotes	spermatocytes
T6409	4605-4608	CHEBI_SO_EXT:DNA	denotes	DNA
T6410	4605-4615	_FRAGMENT	denotes	DNA damage
T6411	4626-4636	GO:0000077	denotes	checkpoint
T6412	4616-4636	GO:0051598	denotes	pachytene checkpoint
T6413	4662-4670	GO:0007129	denotes	synapsis
T6414	4671-4681	GO:0000075	denotes	checkpoint
T6415	4712-4714	CHEBI:44658	denotes	OA
T6416	4728-4734	PR_EXT:000016672	denotes	Trip13
T6417	4740-4753	CL:0000017	denotes	spermatocytes
T6418	4777-4779	GO:0007132	denotes	MI
T6419	4831-4840	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T6420	4841-4850	GO:0000239	denotes	pachytene
T6421	4851-4864	CL:0000017	denotes	spermatocytes
T6422	4926-4935	CHEBI:4911	denotes	etoposide
T6423	4995-5004	GO:0000239	denotes	pachynema
T6424	5014-5024	GO:0000075	denotes	checkpoint
T6425	5025-5033	GO_EXT:reaction_or_response	denotes	response
T6426	5061-5063	CHEBI:44658	denotes	OA
T6427	5082-5097	GO:0042148	denotes	strand invasion
T6428	5109-5115	PR_EXT:000016672	denotes	TRIP13
T6429	5126-5139	CL:0000017	denotes	spermatocytes
T6430	5148-5154	PR_EXT:000016672	denotes	TRIP13
T6431	5206-5209	NCBITaxon:10114	denotes	rat
T6432	5210-5217	UBERON:0002046	denotes	thyroid
T6433	5210-5226	GO_EXT:0004887	denotes	thyroid receptor
T6434	5210-5231	PR_EXT:000016321	denotes	thyroid receptor beta
T6435	5233-5237	PR_EXT:000016321	denotes	THRB
T6436	5275-5279	PR_EXT:000016321	denotes	THRB
T6437	5284-5290	PR_EXT:000016672	denotes	TRIP13
T6438	5294-5301	GO:0007126	denotes	meiosis
T6439	5346-5350	PR_EXT:000016321	denotes	THRB
T6440	5387-5396	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T6441	5397-5409	CL:0000017	denotes	spermatocyte
T6442	5410-5416	GO:0005634	denotes	nuclei
T6443	5442-5444	_FRAGMENT	denotes	XY
T6444	5451-5455	GO:0001741	denotes	body
T6445	5446-5449	_FRAGMENT	denotes	sex
T6446	5504-5511	GO:0005634	denotes	nuclear
T6447	5532-5541	GO:0000239	denotes	pachynema
T6448	5556-5571	GO:0000803	denotes	sex chromosomes
T6449	5560-5571	GO_SO_EXT:chromosome	denotes	chromosomes
T6450	5579-5598	GO:0031507	denotes	heterochromatinized
T6451	5603-5629	GO:0006342	denotes	transcriptionally silenced
T6452	5672-5679	GO:0001741	denotes	XY body
T6453	5704-5710	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T6454	5711-5724	CL:0000017	denotes	spermatocytes
T6455	5751-5758	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T6456	5762-5764	GO:0001741	denotes	XY
T6457	5765-5787	GO:0031507	denotes	heterochromatinization
T6458	5833-5837	PR_EXT:000016321	denotes	THRB
T6459	5847-5851	NCBITaxon:10088	denotes	mice
T6460	5917-5923	PR_EXT:000016672	denotes	TRIP13
T6461	5932-5940	GO_EXT:0004872	denotes	receptor
T6462	5941-5945	PR_EXT:000016321	denotes	THRB
T6463	5949-5956	GO:0007126	denotes	meiosis
T6464	5998-6002	PR_EXT:P38126	denotes	PCH2
T6465	6003-6012	SO_EXT:0000855	denotes	orthologs
T6466	6028-6038	NCBITaxon:2759	denotes	eukaryotic
T6467	6086-6093	CHEBI_PR_EXT:protein	denotes	protein
T6468	6102-6111	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T6469	6119-6125	PR_EXT:000016672	denotes	TRIP13
T6470	6143-6153	GO:0000075	denotes	checkpoint
T6471	6166-6170	NCBITaxon:10088	denotes	mice
T6472	6192-6198	PR_EXT:000016672	denotes	TRIP13
T6473	6199-6203	PR_EXT:P38126	denotes	PCH2
T6474	6214-6221	CHEBI_PR_EXT:protein	denotes	protein
T6475	6240-6253	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6476	6293-6304	NCBITaxon:3702	denotes	A. thaliana
T6477	6331-6349	GO:0033313	denotes	meiotic checkpoint
T6478	6364-6374	GO_EXT:killing	denotes	eliminates
T6479	6375-6381	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T6480	6417-6426	NCBITaxon:1	denotes	organisms
T6481	6435-6439	NCBITaxon:10088	denotes	mice
T6482	6441-6448	GO:0007114	denotes	budding
T6483	6441-6454	NCBITaxon:4892	denotes	budding yeast
T6484	6460-6466	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T6485	6467-6477	NCBITaxon:7215	denotes	Drosophila
T6486	6491-6500	NCBITaxon:40674	denotes	mammalian
T6487	6501-6507	PR_EXT:000016672	denotes	TRIP13
T6488	6527-6538	NCBITaxon:3701	denotes	Arabidopsis
T6489	6539-6543	PR_EXT:P38126	denotes	PCH2
T6490	6553-6556	NCBITaxon:7147	denotes	fly
T6491	6560-6564	NCBITaxon_EXT:worm	denotes	worm
T6492	6565-6573	CHEBI_PR_EXT:protein	denotes	proteins
T6493	6627-6636	NCBITaxon:40674	denotes	mammalian
T6494	6641-6646	NCBITaxon:3193	denotes	plant
T6495	6647-6651	PR_EXT:P38126	denotes	PCH2
T6496	6715-6724	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T6497	6742-6755	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6498	6778-6782	PR_EXT:P38126	denotes	PCH2
T6499	6786-6792	NCBITaxon:3193	denotes	plants
T6500	6839-6849	GO:0000075	denotes	checkpoint
T6501	6913-6920	NCBITaxon:33208	denotes	animals
T6502	6922-6927	NCBITaxon:4751	denotes	fungi
T6503	6933-6939	NCBITaxon:3193	denotes	plants
T6504	6967-6971	PR_EXT:P38126	denotes	PCH2
T6505	6972-6980	SO_EXT:biological_sequence	denotes	sequence
T6506	7060-7070	GO:0000075	denotes	checkpoint
T6507	7084-7088	PR_EXT:P38126	denotes	PCH2
T6508	7134-7144	GO:0000075	denotes	checkpoint
T6509	7179-7184	NCBITaxon_EXT:worm	denotes	worms
T6510	7189-7196	GO:0007114	denotes	budding
T6511	7189-7202	NCBITaxon:4892	denotes	budding yeast
T6512	7255-7259	PR_EXT:P38126	denotes	PCH2
T6513	7269-7278	NCBITaxon:1	denotes	organisms
T6514	7312-7320	GO:0007129	denotes	synapsis
T6515	7321-7331	GO:0000075	denotes	checkpoint
T6516	7335-7339	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T6517	7340-7344	NCBITaxon:10088	denotes	mice
T6518	7393-7397	PR_EXT:Q9SIH2	denotes	Dot1
T6519	7399-7403	PR_EXT:Q04089	denotes	PCH1
T6520	7407-7412	NCBITaxon_EXT:yeast	denotes	yeast
T6521	7417-7424	PR_EXT:000043452	denotes	histone
T6522	7417-7424	CHEBI:15358	denotes	histone
T6523	7417-7442	GO_EXT:0042054	denotes	histone methyltransferase
T6524	7443-7452	GO:0016458	denotes	silencing
T6525	7481-7490	GO:0000239	denotes	pachytene
T6526	7501-7505	PR_EXT:P31111	denotes	zip1
T6527	7510-7514	PR_EXT:000006536	denotes	dmc1
T6528	7515-7522	SO_EXT:sequence_altered_entity	denotes	mutants
T6529	7526-7531	NCBITaxon_EXT:yeast	denotes	yeast
T6530	7557-7562	PR_EXT:000013680	denotes	RAD54
T6531	7572-7587	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinational
T6532	7572-7587	_FRAGMENT	denotes	recombinational
T6533	7592-7598	GO:0000725	denotes	repair
T6534	7588-7598	GO:0006302	denotes	DSB repair
T6535	7635-7639	PR_EXT:Q9SIH2	denotes	DOT1
T6536	7657-7661	PR_EXT:P38126	denotes	PCH2
T6537	7674-7680	PR_EXT:000016672	denotes	TRIP13
T6538	7694-7704	GO:0000075	denotes	checkpoint
T6539	7717-7721	NCBITaxon:10088	denotes	mice
T6540	7744-7753	NCBITaxon:40674	denotes	mammalian
T6541	7754-7758	PR_EXT:Q9SIH2	denotes	DOT1
T6542	7766-7786	GO:0051598	denotes	pachytene checkpoint
T6543	7856-7861	PR_EXT:000003035	denotes	TRP53
T6544	7862-7869	SO_EXT:0000853	denotes	homolog
T6545	7870-7875	PR_EXT:000016567	denotes	TRP63
T6546	7892-7895	CHEBI_SO_EXT:DNA	denotes	DNA
T6547	7911-7916	GO:0016265	denotes	death
T6548	7935-7953	CL:0000654	denotes	primordial oocytes
T6549	8004-8014	GO:0065007	denotes	monitoring
T6550	8015-8021	SO_EXT:0001026	denotes	genome
T6551	8084-8104	GO:0051598	denotes	pachytene checkpoint
T6552	8175-8193	GO:0033313	denotes	meiotic checkpoint
T6553	8194-8199	SO_EXT:0000704	denotes	genes
T6554	8203-8207	NCBITaxon:10088	denotes	mice
T6555	8222-8227	NCBITaxon_EXT:yeast	denotes	yeast
T6556	8234-8239	SO_EXT:0000704	denotes	genes
T6557	8251-8258	GO:0007067	denotes	mitotic
T6558	8278-8283	PR_EXT:P32641	denotes	RAD24
T6559	8319-8328	GO_EXT:fatality_or_lethality	denotes	lethality
T6560	8342-8351	NCBITaxon:40674	denotes	mammalian
T6561	8352-8372	GO:0051598	denotes	pachytene checkpoint
T6562	8389-8398	SO_EXT:0000855	denotes	orthologs
T6563	8425-8434	NCBITaxon:1	denotes	organisms
T6564	8443-8448	NCBITaxon_EXT:yeast	denotes	yeast
R3997	T6234	T6233	_lexicallyChainedTo	repair,recombinational
R3998	T6289	T6288	_lexicallyChainedTo	recombination,CO
R3999	T6356	T6355	_lexicallyChainedTo	complexes,disassembly of
R4000	T6371	T6370	_lexicallyChainedTo	complex disassembly,protein
R4001	T6411	T6410	_lexicallyChainedTo	checkpoint,DNA damage
R4002	T6444	T6443	_lexicallyChainedTo	body,XY
R4003	T6444	T6445	_lexicallyChainedTo	body,sex
R4004	T6533	T6532	_lexicallyChainedTo	repair,recombinational

PMC:1941754 / 30702-39198 JSONTXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

craft-ca-core-dev

2_test

craft-ca-core-ex-dev

PMC:1941754 / 30702-39198 JSON TXT