PMC:1941754 / 25362-29905 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T4919	0-6	NN	denotes	TRIP13
T4920	7-17	NN	denotes	Deficiency
T4921	27-36	VB	denotes	Alleviate
T4922	18-22	VBP	denotes	Does
T4923	23-26	RB	denotes	Not
T4924	37-44	JJ	denotes	Meiotic
T4925	45-51	NN	denotes	Arrest
T4926	52-62	NNS	denotes	Phenotypes
T4927	63-65	IN	denotes	of
T4928	66-73	NNS	denotes	Mutants
T4929	74-83	JJ	denotes	Defective
T4930	84-86	IN	denotes	in
T4931	87-95	NN	denotes	Synapsis
T4932	95-252	sentence	denotes	To determine if TRIP13 deficiency prevents apoptosis triggered by asynapsis as in C. elegans, we analyzed mice that were doubly mutant for Spo11 and Trip13.
T4933	96-98	TO	denotes	To
T4934	99-108	VB	denotes	determine
T4935	193-201	VBD	denotes	analyzed
T4936	109-111	IN	denotes	if
T4937	130-138	VBZ	denotes	prevents
T4938	112-118	NN	denotes	TRIP13
T4939	119-129	NN	denotes	deficiency
T4940	139-148	NN	denotes	apoptosis
T4941	149-158	VBN	denotes	triggered
T4942	159-161	IN	denotes	by
T4943	162-171	NN	denotes	asynapsis
T4944	172-174	IN	denotes	as
T4945	175-177	IN	denotes	in
T4946	178-180	NNP	denotes	C.
T4947	181-188	NNP	denotes	elegans
T4948	188-190	,	denotes	,
T4949	190-192	PRP	denotes	we
T4950	202-206	NNS	denotes	mice
T4951	207-211	WDT	denotes	that
T4952	212-216	VBD	denotes	were
T4953	217-223	RB	denotes	doubly
T4954	224-230	NN	denotes	mutant
T4955	231-234	IN	denotes	for
T4956	235-240	NN	denotes	Spo11
T4957	241-244	CC	denotes	and
T4958	245-251	NN	denotes	Trip13
T4959	251-252	.	denotes	.
T4960	252-399	sentence	denotes	SPO11 is a transesterase that is essential for the creation of genetically programmed DSB during leptonema of many organisms, including mice [18].
T4961	253-258	NN	denotes	SPO11
T4962	259-261	VBZ	denotes	is
T4963	262-263	DT	denotes	a
T4964	264-277	NN	denotes	transesterase
T4965	278-282	WDT	denotes	that
T4966	283-285	VBZ	denotes	is
T4967	286-295	JJ	denotes	essential
T4968	296-299	IN	denotes	for
T4969	300-303	DT	denotes	the
T4970	304-312	NN	denotes	creation
T4971	313-315	IN	denotes	of
T4972	316-327	RB	denotes	genetically
T4973	328-338	VBN	denotes	programmed
T4974	339-342	NN	denotes	DSB
T4975	343-349	IN	denotes	during
T4976	350-359	NN	denotes	leptonema
T4977	360-362	IN	denotes	of
T4978	363-367	JJ	denotes	many
T4979	368-377	NNS	denotes	organisms
T4980	377-379	,	denotes	,
T4981	379-388	VBG	denotes	including
T4982	389-393	NNS	denotes	mice
T4983	394-395	-LRB-	denotes	[
T4984	395-397	CD	denotes	18
T4985	397-398	-RRB-	denotes	]
T4986	398-399	.	denotes	.
T4987	399-521	sentence	denotes	In C. elegans, spo-11 mutant gametes have extensive asynapsis, which triggers PCH-2 dependent apoptosis in pachynema [2].
T4988	400-402	IN	denotes	In
T4989	437-441	VBP	denotes	have
T4990	403-405	NNP	denotes	C.
T4991	406-413	NNP	denotes	elegans
T4992	413-415	,	denotes	,
T4993	415-418	NN	denotes	spo
T4994	429-436	NNS	denotes	gametes
T4995	418-419	HYPH	denotes	-
T4996	419-421	CD	denotes	11
T4997	422-428	NN	denotes	mutant
T4998	442-451	JJ	denotes	extensive
T4999	452-461	NN	denotes	asynapsis
T5000	461-463	,	denotes	,
T5001	463-468	WDT	denotes	which
T5002	469-477	VBZ	denotes	triggers
T5003	478-481	NN	denotes	PCH
T5004	484-493	JJ	denotes	dependent
T5005	481-482	HYPH	denotes	-
T5006	482-483	CD	denotes	2
T5007	494-503	NN	denotes	apoptosis
T5008	504-506	IN	denotes	in
T5009	507-516	NN	denotes	pachynema
T5010	517-518	-LRB-	denotes	[
T5011	518-519	CD	denotes	2
T5012	519-520	-RRB-	denotes	]
T5013	520-521	.	denotes	.
T5014	521-724	sentence	denotes	In mice, Spo11 −/− spermatocytes are severely defective in homologous chromosome synapsis [34,35], and arrest with chromosomes in a state characteristic of the zygotene/pachytene transition (Figure 3H).
T5015	522-524	IN	denotes	In
T5016	555-558	VBP	denotes	are
T5017	525-529	NNS	denotes	mice
T5018	529-531	,	denotes	,
T5019	531-536	NN	denotes	Spo11
T5020	541-554	NNS	denotes	spermatocytes
T5021	537-538	SYM	denotes	−
T5022	538-539	HYPH	denotes	/
T5023	539-540	SYM	denotes	−
T5024	559-567	RB	denotes	severely
T5025	568-577	JJ	denotes	defective
T5026	578-580	IN	denotes	in
T5027	581-591	JJ	denotes	homologous
T5028	603-611	NN	denotes	synapsis
T5029	592-602	NN	denotes	chromosome
T5030	612-613	-LRB-	denotes	[
T5031	616-618	CD	denotes	35
T5032	613-615	CD	denotes	34
T5033	615-616	,	denotes	,
T5034	618-619	-RRB-	denotes	]
T5035	619-621	,	denotes	,
T5036	621-624	CC	denotes	and
T5037	625-631	VBP	denotes	arrest
T5038	632-636	IN	denotes	with
T5039	637-648	NNS	denotes	chromosomes
T5040	649-651	IN	denotes	in
T5041	652-653	DT	denotes	a
T5042	654-659	NN	denotes	state
T5043	660-674	JJ	denotes	characteristic
T5044	675-677	IN	denotes	of
T5045	678-681	DT	denotes	the
T5046	701-711	NN	denotes	transition
T5047	682-690	NN	denotes	zygotene
T5048	691-700	NN	denotes	pachytene
T5049	690-691	HYPH	denotes	/
T5050	712-713	-LRB-	denotes	(
T5051	720-722	NN	denotes	3H
T5052	713-719	NN	denotes	Figure
T5053	722-723	-RRB-	denotes	)
T5054	723-724	.	denotes	.
T5055	724-922	sentence	denotes	Spermatocytes in Trip13Gt/Gt Spo11 −/− testes progressed maximally to that point before undergoing death (Figs 3I), well before the spindle checkpoint that eliminates achiasmate spermatocytes [36].
T5056	725-738	NNS	denotes	Spermatocytes
T5057	771-781	VBD	denotes	progressed
T5058	739-741	IN	denotes	in
T5059	742-750	NN	denotes	Trip13Gt
T5060	751-753	NN	denotes	Gt
T5061	750-751	HYPH	denotes	/
T5062	764-770	NNS	denotes	testes
T5063	754-759	NN	denotes	Spo11
T5064	760-761	SYM	denotes	−
T5065	761-762	HYPH	denotes	/
T5066	762-763	SYM	denotes	−
T5067	782-791	RB	denotes	maximally
T5068	792-794	IN	denotes	to
T5069	795-799	DT	denotes	that
T5070	800-805	NN	denotes	point
T5071	806-812	IN	denotes	before
T5072	813-823	VBG	denotes	undergoing
T5073	824-829	NN	denotes	death
T5074	830-831	-LRB-	denotes	(
T5075	836-838	NN	denotes	3I
T5076	831-835	NNS	denotes	Figs
T5077	838-839	-RRB-	denotes	)
T5078	839-841	,	denotes	,
T5079	841-845	RB	denotes	well
T5080	846-852	IN	denotes	before
T5081	853-856	DT	denotes	the
T5082	865-875	NN	denotes	checkpoint
T5083	857-864	NN	denotes	spindle
T5084	876-880	WDT	denotes	that
T5085	881-891	VBZ	denotes	eliminates
T5086	892-902	NN	denotes	achiasmate
T5087	903-916	NNS	denotes	spermatocytes
T5088	917-918	-LRB-	denotes	[
T5089	918-920	CD	denotes	36
T5090	920-921	-RRB-	denotes	]
T5091	921-922	.	denotes	.
T5092	922-1072	sentence	denotes	There was no evidence of metaphase I spermatocytes or postmeiotic spermatids in these testes, unlike those seen in Trip13 single mutants (Figure 3G).
T5093	923-928	EX	denotes	There
T5094	929-932	VBD	denotes	was
T5095	933-935	DT	denotes	no
T5096	936-944	NN	denotes	evidence
T5097	945-947	IN	denotes	of
T5098	948-957	NN	denotes	metaphase
T5099	960-973	NNS	denotes	spermatocytes
T5100	958-959	CD	denotes	I
T5101	974-976	CC	denotes	or
T5102	977-988	JJ	denotes	postmeiotic
T5103	989-999	NNS	denotes	spermatids
T5104	1000-1002	IN	denotes	in
T5105	1003-1008	DT	denotes	these
T5106	1009-1015	NNS	denotes	testes
T5107	1015-1017	,	denotes	,
T5108	1017-1023	IN	denotes	unlike
T5109	1024-1029	DT	denotes	those
T5110	1030-1034	VBN	denotes	seen
T5111	1035-1037	IN	denotes	in
T5112	1038-1044	NN	denotes	Trip13
T5113	1052-1059	NNS	denotes	mutants
T5114	1045-1051	JJ	denotes	single
T5115	1060-1061	-LRB-	denotes	(
T5116	1068-1070	NN	denotes	3G
T5117	1061-1067	NN	denotes	Figure
T5118	1070-1071	-RRB-	denotes	)
T5119	1071-1072	.	denotes	.
T5120	1072-1412	sentence	denotes	In contrast to the complete synapsis in Trip13Gt/Gt pachytene spermatocytes (Figure 5A), in which SPO11 is available in leptonema to initiate (via DSB induction, Figure S2A and S2B) a recombination-driven homolog search, chromosome synapsis in doubly mutant spermatocytes was highly disrupted as in Spo11 single mutants (Figure 5B and 5C).
T5121	1073-1075	IN	denotes	In
T5122	1356-1365	VBN	denotes	disrupted
T5123	1076-1084	NN	denotes	contrast
T5124	1085-1087	IN	denotes	to
T5125	1088-1091	DT	denotes	the
T5126	1101-1109	NN	denotes	synapsis
T5127	1092-1100	JJ	denotes	complete
T5128	1110-1112	IN	denotes	in
T5129	1113-1121	NN	denotes	Trip13Gt
T5130	1122-1124	NN	denotes	Gt
T5131	1121-1122	HYPH	denotes	/
T5132	1125-1134	NN	denotes	pachytene
T5133	1135-1148	NNS	denotes	spermatocytes
T5134	1149-1150	-LRB-	denotes	(
T5135	1157-1159	NN	denotes	5A
T5136	1150-1156	NN	denotes	Figure
T5137	1159-1160	-RRB-	denotes	)
T5138	1160-1162	,	denotes	,
T5139	1162-1164	IN	denotes	in
T5140	1177-1179	VBZ	denotes	is
T5141	1165-1170	WDT	denotes	which
T5142	1171-1176	NN	denotes	SPO11
T5143	1180-1189	JJ	denotes	available
T5144	1190-1192	IN	denotes	in
T5145	1193-1202	NN	denotes	leptonema
T5146	1203-1205	TO	denotes	to
T5147	1206-1214	VB	denotes	initiate
T5148	1215-1216	-LRB-	denotes	(
T5149	1242-1245	NN	denotes	S2A
T5150	1216-1219	IN	denotes	via
T5151	1220-1223	NN	denotes	DSB
T5152	1224-1233	NN	denotes	induction
T5153	1233-1235	,	denotes	,
T5154	1235-1241	NN	denotes	Figure
T5155	1246-1249	CC	denotes	and
T5156	1250-1253	NN	denotes	S2B
T5157	1253-1254	-RRB-	denotes	)
T5158	1255-1256	DT	denotes	a
T5159	1286-1292	NN	denotes	search
T5160	1257-1270	NN	denotes	recombination
T5161	1271-1277	VBN	denotes	driven
T5162	1270-1271	HYPH	denotes	-
T5163	1278-1285	NN	denotes	homolog
T5164	1292-1294	,	denotes	,
T5165	1294-1304	NN	denotes	chromosome
T5166	1305-1313	NN	denotes	synapsis
T5167	1314-1316	IN	denotes	in
T5168	1317-1323	RB	denotes	doubly
T5169	1324-1330	JJ	denotes	mutant
T5170	1331-1344	NNS	denotes	spermatocytes
T5171	1345-1348	VBD	denotes	was
T5172	1349-1355	RB	denotes	highly
T5173	1366-1368	IN	denotes	as
T5174	1369-1371	IN	denotes	in
T5175	1372-1377	NN	denotes	Spo11
T5176	1385-1392	NNS	denotes	mutants
T5177	1378-1384	JJ	denotes	single
T5178	1393-1394	-LRB-	denotes	(
T5179	1401-1403	NN	denotes	5B
T5180	1394-1400	NN	denotes	Figure
T5181	1404-1407	CC	denotes	and
T5182	1408-1410	NN	denotes	5C
T5183	1410-1411	-RRB-	denotes	)
T5184	1411-1412	.	denotes	.
T5185	1412-1631	sentence	denotes	Identical studies were performed with mice deficient for Mei1, a vertebrate-specific gene also required for DSB formation and chromosome synapsis [37], with similar results (Figure 3J and 3K; immunocytology not shown).
T5186	1413-1422	JJ	denotes	Identical
T5187	1423-1430	NNS	denotes	studies
T5188	1436-1445	VBN	denotes	performed
T5189	1431-1435	VBD	denotes	were
T5190	1446-1450	IN	denotes	with
T5191	1451-1455	NNS	denotes	mice
T5192	1456-1465	JJ	denotes	deficient
T5235	1960-1961	IN	denotes	t
T5236	1961-1965	sentence	denotes	, de
T5237	1961-1963	,	denotes	,
T5238	1963-1964	JJ	denotes	d
T5239	1964-1965	NNS	denotes	e
T5240	1965-1973	sentence	denotes	letion o
T5241	1965-1967	JJR	denotes	le
T5242	1967-1971	NN	denotes	tion
T5243	1972-1973	TO	denotes	o
T5244	1973-2058	sentence	denotes	f PCH2 alleviates the pachytene arrest caused by asynaptic mutants zip1 and zip2 [8].
T5245	1980-1990	VBZ	denotes	alleviates
T5246	1973-1974	IN	denotes	f
T5247	1975-1979	NN	denotes	PCH2
T5248	1991-1994	DT	denotes	the
T5249	2005-2011	NN	denotes	arrest
T5250	1995-2004	NN	denotes	pachytene
T5251	2012-2018	VBN	denotes	caused
T5252	2019-2021	IN	denotes	by
T5253	2022-2031	JJ	denotes	asynaptic
T5254	2040-2044	NN	denotes	zip1
T5255	2032-2039	NNS	denotes	mutants
T5256	2045-2048	CC	denotes	and
T5257	2049-2053	NN	denotes	zip2
T5258	2054-2055	-LRB-	denotes	[
T5259	2055-2056	CD	denotes	8
T5260	2056-2057	-RRB-	denotes	]
T5261	2057-2058	.	denotes	.
T5262	2058-2277	sentence	denotes	Although mouse SYCP1 might be a functional equivalent of Zip1p, because Sycp1 mutant spermatocytes arrest at approximately the same point as Trip13 mutants, there would be no opportunity to observe bypass of Sycp1 −/−.
T5263	2059-2067	IN	denotes	Although
T5264	2086-2088	VB	denotes	be
T5265	2068-2073	NN	denotes	mouse
T5266	2074-2079	NN	denotes	SYCP1
T5267	2080-2085	MD	denotes	might
T5268	2228-2230	VB	denotes	be
T5269	2089-2090	DT	denotes	a
T5270	2102-2112	NN	denotes	equivalent
T5271	2091-2101	JJ	denotes	functional
T5272	2113-2115	IN	denotes	of
T5273	2116-2121	NN	denotes	Zip1p
T5274	2121-2123	,	denotes	,
T5275	2123-2130	IN	denotes	because
T5276	2158-2164	VBP	denotes	arrest
T5277	2131-2136	NN	denotes	Sycp1
T5278	2144-2157	NNS	denotes	spermatocytes
T5279	2137-2143	NN	denotes	mutant
T5280	2165-2167	IN	denotes	at
T5281	2168-2181	RB	denotes	approximately
T5282	2191-2196	NN	denotes	point
T5283	2182-2185	DT	denotes	the
T5284	2186-2190	JJ	denotes	same
T5285	2197-2199	IN	denotes	as
T5286	2200-2206	NN	denotes	Trip13
T5287	2207-2214	NNS	denotes	mutants
T5288	2214-2216	,	denotes	,
T5289	2216-2221	EX	denotes	there
T5290	2222-2227	MD	denotes	would
T5291	2231-2233	DT	denotes	no
T5292	2234-2245	NN	denotes	opportunity
T5293	2246-2248	TO	denotes	to
T5294	2249-2256	VB	denotes	observe
T5295	2257-2263	NN	denotes	bypass
T5296	2264-2266	IN	denotes	of
T5297	2267-2272	NN	denotes	Sycp1
T5298	2273-2274	SYM	denotes	−
T5299	2274-2275	HYPH	denotes	/
T5300	2275-2276	SYM	denotes	−
T5301	2276-2277	.	denotes	.
T5302	2277-2436	sentence	denotes	Since Zip2p is present at sites of axial associations, even in zip1 mutants, it has been suggested that Zip2p promotes initiation of chromosome synapsis [38].
T5303	2278-2283	IN	denotes	Since
T5304	2290-2292	VBZ	denotes	is
T5305	2284-2289	NN	denotes	Zip2p
T5306	2367-2376	VBN	denotes	suggested
T5307	2293-2300	JJ	denotes	present
T5308	2301-2303	IN	denotes	at
T5309	2304-2309	NNS	denotes	sites
T5310	2310-2312	IN	denotes	of
T5311	2313-2318	JJ	denotes	axial
T5312	2319-2331	NNS	denotes	associations
T5313	2331-2333	,	denotes	,
T5314	2333-2337	RB	denotes	even
T5315	2338-2340	IN	denotes	in
T5316	2341-2345	NN	denotes	zip1
T5317	2346-2353	NNS	denotes	mutants
T5318	2353-2355	,	denotes	,
T5319	2355-2357	PRP	denotes	it
T5320	2358-2361	VBZ	denotes	has
T5321	2362-2366	VBN	denotes	been
T5322	2377-2381	IN	denotes	that
T5323	2388-2396	VBZ	denotes	promotes
T5324	2382-2387	NN	denotes	Zip2p
T5325	2397-2407	NN	denotes	initiation
T5326	2408-2410	IN	denotes	of
T5327	2411-2421	NN	denotes	chromosome
T5328	2422-2430	NN	denotes	synapsis
T5329	2431-2432	-LRB-	denotes	[
T5330	2432-2434	CD	denotes	38
T5331	2434-2435	-RRB-	denotes	]
T5332	2435-2436	.	denotes	.
T5333	2436-2558	sentence	denotes	These observations raise the possibility that in yeast, Pch2p responds to synapsis polymerization rather than initiation.
T5334	2437-2442	DT	denotes	These
T5335	2443-2455	NNS	denotes	observations
T5336	2456-2461	VBP	denotes	raise
T5337	2462-2465	DT	denotes	the
T5338	2466-2477	NN	denotes	possibility
T5339	2478-2482	IN	denotes	that
T5340	2499-2507	VBZ	denotes	responds
T5341	2483-2485	IN	denotes	in
T5342	2486-2491	NN	denotes	yeast
T5343	2491-2493	,	denotes	,
T5344	2493-2498	NN	denotes	Pch2p
T5345	2508-2510	IN	denotes	to
T5346	2511-2519	NN	denotes	synapsis
T5347	2520-2534	NN	denotes	polymerization
T5348	2535-2541	RB	denotes	rather
T5349	2542-2546	IN	denotes	than
T5350	2547-2557	NN	denotes	initiation
T5351	2557-2558	.	denotes	.
T5352	2558-2658	sentence	denotes	To test this, we performed epistasis analysis with a Rec8 allele (Rec8Mei8, abbreviated as Rec8 −).
T5353	2559-2561	TO	denotes	To
T5354	2562-2566	VB	denotes	test
T5355	2576-2585	VBD	denotes	performed
T5356	2567-2571	DT	denotes	this
T5357	2571-2573	,	denotes	,
T5358	2573-2575	PRP	denotes	we
T5359	2586-2595	NN	denotes	epistasis
T5360	2596-2604	NN	denotes	analysis
T5361	2605-2609	IN	denotes	with
T5362	2610-2611	DT	denotes	a
T5363	2617-2623	NN	denotes	allele
T5364	2612-2616	NN	denotes	Rec8
T5365	2624-2625	-LRB-	denotes	(
T5366	2625-2633	NN	denotes	Rec8Mei8
T5367	2633-2635	,	denotes	,
T5368	2635-2646	VBN	denotes	abbreviated
T5369	2647-2649	IN	denotes	as
T5370	2650-2654	NN	denotes	Rec8
T5371	2655-2656	SYM	denotes	−
T5372	2656-2657	-RRB-	denotes	)
T5373	2657-2658	.	denotes	.
T5374	2658-2862	sentence	denotes	Meiotic chromosomes of Rec8 mutant spermatocytes undergo apparent homolog pairing and interhomolog synaptic initiation, but are defective in DSB repair and fail to maintain interhomolog synapsis [39,40].
T5375	2659-2666	JJ	denotes	Meiotic
T5376	2667-2678	NNS	denotes	chromosomes
T5377	2708-2715	VBP	denotes	undergo
T5378	2679-2681	IN	denotes	of
T5379	2682-2686	NN	denotes	Rec8
T5380	2694-2707	NNS	denotes	spermatocytes
T5381	2687-2693	NN	denotes	mutant
T5382	2716-2724	JJ	denotes	apparent
T5383	2733-2740	NN	denotes	pairing
T5384	2725-2732	NN	denotes	homolog
T5385	2741-2744	CC	denotes	and
T5386	2745-2757	JJ	denotes	interhomolog
T5387	2767-2777	NN	denotes	initiation
T5388	2758-2766	JJ	denotes	synaptic
T5389	2777-2779	,	denotes	,
T5390	2779-2782	CC	denotes	but
T5391	2783-2786	VBP	denotes	are
T5392	2787-2796	JJ	denotes	defective
T5393	2797-2799	IN	denotes	in
T5394	2800-2803	NN	denotes	DSB
T5395	2804-2810	NN	denotes	repair
T5396	2811-2814	CC	denotes	and
T5397	2815-2819	VBP	denotes	fail
T5398	2820-2822	TO	denotes	to
T5399	2823-2831	VB	denotes	maintain
T5400	2832-2844	JJ	denotes	interhomolog
T5401	2845-2853	NN	denotes	synapsis
T5402	2854-2855	-LRB-	denotes	[
T5403	2858-2860	CD	denotes	40
T5404	2855-2857	CD	denotes	39
T5405	2857-2858	,	denotes	,
T5406	2860-2861	-RRB-	denotes	]
T5407	2861-2862	.	denotes	.
T5408	2862-2947	sentence	denotes	Rather, sister chromatids appear to synapse and are bound by SYCP1 along their axes.
T5409	2863-2869	RB	denotes	Rather
T5410	2889-2895	VBP	denotes	appear
T5411	2869-2871	,	denotes	,
T5412	2871-2877	NN	denotes	sister
T5413	2878-2888	NNS	denotes	chromatids
T5414	2896-2898	TO	denotes	to
T5415	2899-2906	VB	denotes	synapse
T5416	2907-2910	CC	denotes	and
T5417	2911-2914	VBP	denotes	are
T5418	2915-2920	VBN	denotes	bound
T5419	2921-2923	IN	denotes	by
T5420	2924-2929	NN	denotes	SYCP1
T5421	2930-2935	IN	denotes	along
T5422	2936-2941	PRP$	denotes	their
T5423	2942-2946	NNS	denotes	axes
T5424	2946-2947	.	denotes	.
T5425	2947-3005	sentence	denotes	Rec8 mutants do not progress to diplonema or metaphase I.
T5426	2948-2952	NN	denotes	Rec8
T5427	2953-2960	NNS	denotes	mutants
T5428	2968-2976	VB	denotes	progress
T5429	2961-2963	VBP	denotes	do
T5430	2964-2967	RB	denotes	not
T5431	2977-2979	IN	denotes	to
T5432	2980-2989	NN	denotes	diplonema
T5433	2990-2992	CC	denotes	or
T5434	2993-3002	NN	denotes	metaphase
T5435	3003-3004	CD	denotes	I
T5436	3004-3005	.	denotes	.
T5437	3005-3072	sentence	denotes	Double mutant analysis indicated that Rec8 is epistatic to Trip13.
T5438	3006-3012	JJ	denotes	Double
T5439	3020-3028	NN	denotes	analysis
T5440	3013-3019	NN	denotes	mutant
T5441	3029-3038	VBD	denotes	indicated
T5442	3039-3043	IN	denotes	that
T5443	3049-3051	VBZ	denotes	is
T5444	3044-3048	NN	denotes	Rec8
T5445	3052-3061	JJ	denotes	epistatic
T5446	3062-3064	IN	denotes	to
T5447	3065-3071	NN	denotes	Trip13
T5448	3071-3072	.	denotes	.
T5449	3072-3291	sentence	denotes	As in the Spo11 and Mei1 experiments, histology of testes deficient for both REC8 and TRIP13 resembled the Rec8 mutant, with no evidence of progression to metaphase I that occurs in Trip13Gt/Gt mice (Figure 3L and 3M).
T5450	3073-3075	IN	denotes	As
T5451	3166-3175	VBD	denotes	resembled
T5452	3076-3078	IN	denotes	in
T5453	3079-3082	DT	denotes	the
T5454	3098-3109	NNS	denotes	experiments
T5455	3083-3088	NN	denotes	Spo11
T5456	3089-3092	CC	denotes	and
T5457	3093-3097	NN	denotes	Mei1
T5458	3109-3111	,	denotes	,
T5459	3111-3120	NN	denotes	histology
T5460	3121-3123	IN	denotes	of
T5461	3124-3130	NNS	denotes	testes
T5462	3131-3140	JJ	denotes	deficient
T5463	3141-3144	IN	denotes	for
T5464	3145-3149	CC	denotes	both
T5465	3150-3154	NN	denotes	REC8
T5466	3155-3158	CC	denotes	and
T5467	3159-3165	NN	denotes	TRIP13
T5468	3176-3179	DT	denotes	the
T5469	3185-3191	NN	denotes	mutant
T5470	3180-3184	NN	denotes	Rec8
T5471	3191-3193	,	denotes	,
T5472	3193-3197	IN	denotes	with
T5473	3198-3200	DT	denotes	no
T5474	3201-3209	NN	denotes	evidence
T5475	3210-3212	IN	denotes	of
T5476	3213-3224	NN	denotes	progression
T5477	3225-3227	IN	denotes	to
T5478	3228-3237	NN	denotes	metaphase
T5479	3238-3239	CD	denotes	I
T5480	3240-3244	WDT	denotes	that
T5481	3245-3251	VBZ	denotes	occurs
T5482	3252-3254	IN	denotes	in
T5483	3255-3263	NN	denotes	Trip13Gt
T5484	3264-3266	NN	denotes	Gt
T5485	3263-3264	HYPH	denotes	/
T5486	3267-3271	NNS	denotes	mice
T5487	3272-3273	-LRB-	denotes	(
T5488	3280-3282	NN	denotes	3L
T5489	3273-3279	NN	denotes	Figure
T5490	3283-3286	CC	denotes	and
T5491	3287-3289	NN	denotes	3M
T5492	3289-3290	-RRB-	denotes	)
T5493	3290-3291	.	denotes	.
T5494	3291-3520	sentence	denotes	Immunocytological analysis of spread chromosomes showed a failure of homologous chromosome synapsis in both the Rec8 −/− and Rec8 −/− Trip13Gt/Gt spermatocytes, as previously reported for Rec8 mutants (Figure 5D and 5E) [39,40].
T5495	3292-3309	JJ	denotes	Immunocytological
T5496	3310-3318	NN	denotes	analysis
T5497	3341-3347	VBD	denotes	showed
T5498	3319-3321	IN	denotes	of
T5499	3322-3328	NN	denotes	spread
T5500	3329-3340	NNS	denotes	chromosomes
T5501	3348-3349	DT	denotes	a
T5502	3350-3357	NN	denotes	failure
T5503	3358-3360	IN	denotes	of
T5504	3361-3371	JJ	denotes	homologous
T5505	3383-3391	NN	denotes	synapsis
T5506	3372-3382	NN	denotes	chromosome
T5507	3392-3394	IN	denotes	in
T5508	3395-3399	CC	denotes	both
T5509	3438-3451	NNS	denotes	spermatocytes
T5510	3400-3403	DT	denotes	the
T5511	3404-3408	NN	denotes	Rec8
T5512	3409-3410	SYM	denotes	−
T5513	3410-3411	HYPH	denotes	/
T5514	3411-3412	SYM	denotes	−
T5515	3413-3416	CC	denotes	and
T5516	3417-3421	NN	denotes	Rec8
T5517	3435-3437	NN	denotes	Gt
T5518	3422-3423	SYM	denotes	−
T5519	3423-3424	HYPH	denotes	/
T5520	3424-3425	SYM	denotes	−
T5521	3426-3434	NN	denotes	Trip13Gt
T5522	3434-3435	HYPH	denotes	/
T5523	3451-3453	,	denotes	,
T5524	3453-3455	IN	denotes	as
T5525	3467-3475	VBN	denotes	reported
T5526	3456-3466	RB	denotes	previously
T5527	3476-3479	IN	denotes	for
T5528	3480-3484	NN	denotes	Rec8
T5529	3485-3492	NNS	denotes	mutants
T5530	3493-3494	-LRB-	denotes	(
T5531	3501-3503	NN	denotes	5D
T5532	3494-3500	NN	denotes	Figure
T5533	3504-3507	CC	denotes	and
T5534	3508-3510	NN	denotes	5E
T5535	3510-3511	-RRB-	denotes	)
T5536	3512-3513	-LRB-	denotes	[
T5537	3516-3518	CD	denotes	40
T5538	3513-3515	CD	denotes	39
T5539	3515-3516	,	denotes	,
T5540	3518-3519	-RRB-	denotes	]
T5541	3519-3520	.	denotes	.
T5542	3520-3723	sentence	denotes	Although subsequent reports indicate otherwise [10,12], deletion of PCH2 in yeast was originally reported to alleviate meiotic arrest caused by deficiency for the meiosis-specific RecA homolog DMC1 [8].
T5543	3521-3529	IN	denotes	Although
T5544	3549-3557	VBP	denotes	indicate
T5545	3530-3540	JJ	denotes	subsequent
T5546	3541-3548	NNS	denotes	reports
T5547	3618-3626	VBN	denotes	reported
T5548	3558-3567	RB	denotes	otherwise
T5549	3568-3569	-LRB-	denotes	[
T5550	3572-3574	CD	denotes	12
T5551	3569-3571	CD	denotes	10
T5552	3571-3572	,	denotes	,
T5553	3574-3575	-RRB-	denotes	]
T5554	3575-3577	,	denotes	,
T5555	3577-3585	NN	denotes	deletion
T5556	3586-3588	IN	denotes	of
T5557	3589-3593	NN	denotes	PCH2
T5558	3594-3596	IN	denotes	in
T5559	3597-3602	NN	denotes	yeast
T5560	3603-3606	VBD	denotes	was
T5561	3607-3617	RB	denotes	originally
T5562	3627-3629	TO	denotes	to
T5563	3630-3639	VB	denotes	alleviate
T5564	3640-3647	JJ	denotes	meiotic
T5565	3648-3654	NN	denotes	arrest
T5566	3655-3661	VBN	denotes	caused
T5567	3662-3664	IN	denotes	by
T5568	3665-3675	NN	denotes	deficiency
T5569	3676-3679	IN	denotes	for
T5570	3680-3683	DT	denotes	the
T5571	3706-3713	NN	denotes	homolog
T5572	3684-3691	NN	denotes	meiosis
T5573	3692-3700	JJ	denotes	specific
T5574	3691-3692	HYPH	denotes	-
T5575	3701-3705	NN	denotes	RecA
T5576	3714-3718	NN	denotes	DMC1
T5577	3719-3720	-LRB-	denotes	[
T5578	3720-3721	CD	denotes	8
T5579	3721-3722	-RRB-	denotes	]
T5580	3722-3723	.	denotes	.
T5581	3723-3823	sentence	denotes	To investigate this relationship in mice, we constructed animals doubly mutant for Trip13 and Dmc1.
T5582	3724-3726	TO	denotes	To
T5583	3727-3738	VB	denotes	investigate
T5584	3769-3780	VBD	denotes	constructed
T5585	3739-3743	DT	denotes	this
T5586	3744-3756	NN	denotes	relationship
T5587	3757-3759	IN	denotes	in
T5588	3760-3764	NNS	denotes	mice
T5589	3764-3766	,	denotes	,
T5590	3766-3768	PRP	denotes	we
T5591	3781-3788	NNS	denotes	animals
T5592	3789-3795	RB	denotes	doubly
T5593	3796-3802	JJ	denotes	mutant
T5594	3803-3806	IN	denotes	for
T5595	3807-3813	NN	denotes	Trip13
T5596	3814-3817	CC	denotes	and
T5597	3818-3822	NN	denotes	Dmc1
T5598	3822-3823	.	denotes	.
T5599	3823-4126	sentence	denotes	As in Dmc1 −/− mice, in which spermatocytes undergo meiotic arrest from defective DSB repair and failed chromosome synapsis [16], spermatogenesis in Dmc1 −/− Trip13Gt/Gt testes was uniformly arrested at the point where spermatocytes contained chromatin characteristic of zygonema/pachynema (Figure 3N).
T5600	3824-3826	IN	denotes	As
T5601	4015-4023	VBN	denotes	arrested
T5602	3827-3829	IN	denotes	in
T5603	3830-3834	NN	denotes	Dmc1
T5604	3839-3843	NNS	denotes	mice
T5605	3835-3836	SYM	denotes	−
T5606	3836-3837	HYPH	denotes	/
T5607	3837-3838	SYM	denotes	−
T5608	3843-3845	,	denotes	,
T5609	3845-3847	IN	denotes	in
T5610	3868-3875	VBP	denotes	undergo
T5611	3848-3853	WDT	denotes	which
T5612	3854-3867	NNS	denotes	spermatocytes
T5613	3876-3883	JJ	denotes	meiotic
T5614	3884-3890	NN	denotes	arrest
T5615	3891-3895	IN	denotes	from
T5616	3896-3905	JJ	denotes	defective
T5617	3910-3916	NN	denotes	repair
T5618	3906-3909	NN	denotes	DSB
T5619	3917-3920	CC	denotes	and
T5620	3921-3927	VBN	denotes	failed
T5621	3939-3947	NN	denotes	synapsis
T5622	3928-3938	NN	denotes	chromosome
T5623	3948-3949	-LRB-	denotes	[
T5624	3949-3951	CD	denotes	16
T5625	3951-3952	-RRB-	denotes	]
T5626	3952-3954	,	denotes	,
T5627	3954-3969	NN	denotes	spermatogenesis
T5628	3970-3972	IN	denotes	in
T5629	3973-3977	NN	denotes	Dmc1
T5630	3994-4000	NNS	denotes	testes
T5631	3978-3979	SYM	denotes	−
T5632	3979-3980	HYPH	denotes	/
T5633	3980-3981	SYM	denotes	−
T5634	3982-3990	NN	denotes	Trip13Gt
T5635	3991-3993	NN	denotes	Gt
T5636	3990-3991	HYPH	denotes	/
T5637	4001-4004	VBD	denotes	was
T5638	4005-4014	RB	denotes	uniformly
T5639	4024-4026	IN	denotes	at
T5640	4027-4030	DT	denotes	the
T5641	4031-4036	NN	denotes	point
T5642	4037-4042	WRB	denotes	where
T5643	4057-4066	VBD	denotes	contained
T5644	4043-4056	NNS	denotes	spermatocytes
T5645	4067-4076	NN	denotes	chromatin
T5646	4077-4091	JJ	denotes	characteristic
T5647	4092-4094	IN	denotes	of
T5648	4095-4103	NN	denotes	zygonema
T5649	4104-4113	NN	denotes	pachynema
T5650	4103-4104	HYPH	denotes	/
T5651	4114-4115	-LRB-	denotes	(
T5652	4122-4124	NN	denotes	3N
T5653	4115-4121	NN	denotes	Figure
T5654	4124-4125	-RRB-	denotes	)
T5655	4125-4126	.	denotes	.
T5656	4126-4426	sentence	denotes	Immunocytological analysis indicated that both Dmc1 −/− and Dmc1 −/− Trip13Gt/Gt chromosomes had extensive asynapsis compared to Trip13Gt single mutants (Figure 5F–5H), and all had persistent RAD51/DMC1 foci and phosphorylated H2AX (γH2AX; Figure 5I–5L), confirming that Dmc1 is epistatic to Trip13.
T5657	4127-4144	JJ	denotes	Immunocytological
T5658	4145-4153	NN	denotes	analysis
T5659	4154-4163	VBD	denotes	indicated
T5660	4164-4168	IN	denotes	that
T5661	4220-4223	VBD	denotes	had
T5662	4169-4173	CC	denotes	both
T5663	4174-4178	NN	denotes	Dmc1
T5664	4208-4219	NNS	denotes	chromosomes
T5665	4179-4180	SYM	denotes	−
T5666	4180-4181	HYPH	denotes	/
T5667	4181-4182	SYM	denotes	−
T5668	4183-4186	CC	denotes	and
T5669	4187-4191	NN	denotes	Dmc1
T5670	4205-4207	NN	denotes	Gt
T5671	4192-4193	SYM	denotes	−
T5672	4193-4194	HYPH	denotes	/
T5673	4194-4195	SYM	denotes	−
T5674	4196-4204	NN	denotes	Trip13Gt
T5675	4204-4205	HYPH	denotes	/
T5676	4224-4233	JJ	denotes	extensive
T5677	4234-4243	NN	denotes	asynapsis
T5678	4244-4252	VBN	denotes	compared
T5679	4253-4255	IN	denotes	to
T5680	4256-4264	NN	denotes	Trip13Gt
T5681	4272-4279	NNS	denotes	mutants
T5682	4265-4271	JJ	denotes	single
T5683	4280-4281	-LRB-	denotes	(
T5684	4291-4293	NN	denotes	5H
T5685	4281-4287	NN	denotes	Figure
T5686	4288-4290	NN	denotes	5F
T5687	4290-4291	SYM	denotes	–
T5688	4293-4294	-RRB-	denotes	)
T5689	4294-4296	,	denotes	,
T5690	4296-4299	CC	denotes	and
T5691	4300-4303	DT	denotes	all
T5692	4304-4307	VBD	denotes	had
T5693	4308-4318	JJ	denotes	persistent
T5694	4330-4334	NNS	denotes	foci
T5695	4319-4324	NN	denotes	RAD51
T5696	4325-4329	NN	denotes	DMC1
T5697	4324-4325	HYPH	denotes	/
T5698	4335-4338	CC	denotes	and
T5699	4339-4353	VBN	denotes	phosphorylated
T5700	4354-4358	NN	denotes	H2AX
T5701	4359-4360	-LRB-	denotes	(
T5702	4377-4379	NN	denotes	5L
T5703	4360-4365	NN	denotes	γH2AX
T5704	4365-4366	:	denotes	;
T5705	4367-4373	NN	denotes	Figure
T5706	4374-4376	NN	denotes	5I
T5707	4376-4377	SYM	denotes	–
T5708	4379-4380	-RRB-	denotes	)
T5709	4380-4382	,	denotes	,
T5710	4382-4392	VBG	denotes	confirming
T5711	4393-4397	IN	denotes	that
T5712	4403-4405	VBZ	denotes	is
T5713	4398-4402	NN	denotes	Dmc1
T5714	4406-4415	JJ	denotes	epistatic
T5715	4416-4418	IN	denotes	to
T5716	4419-4425	NN	denotes	Trip13
T5717	4425-4426	.	denotes	.
T5718	4426-4543	sentence	denotes	Doubly mutant females had residual ovaries, phenocopying Dmc1 −/− and Trip13Gt/Gt single mutants (unpublished data).
T5719	4427-4433	RB	denotes	Doubly
T5720	4434-4440	JJ	denotes	mutant
T5721	4441-4448	NNS	denotes	females
T5722	4449-4452	VBD	denotes	had
T5723	4453-4461	JJ	denotes	residual
T5724	4462-4469	NNS	denotes	ovaries
T5725	4469-4471	,	denotes	,
T5726	4471-4483	VBG	denotes	phenocopying
T5727	4484-4488	NN	denotes	Dmc1
T5728	4516-4523	NNS	denotes	mutants
T5729	4489-4490	SYM	denotes	−
T5730	4490-4491	HYPH	denotes	/
T5731	4491-4492	SYM	denotes	−
T5732	4493-4496	CC	denotes	and
T5733	4497-4505	NN	denotes	Trip13Gt
T5734	4506-4508	NN	denotes	Gt
T5735	4505-4506	HYPH	denotes	/
T5736	4509-4515	JJ	denotes	single
T5737	4524-4525	-LRB-	denotes	(
T5738	4537-4541	NNS	denotes	data
T5739	4525-4536	JJ	denotes	unpublished
T5740	4541-4542	-RRB-	denotes	)
T5741	4542-4543	.	denotes	.
T12149	1800-1803	VBP	denotes	are
T12150	1813-1815	,	denotes	,
T12151	1815-1817	IN	denotes	as
T12152	1818-1821	VBP	denotes	are
T12153	1822-1827	DT	denotes	those
T12154	1828-1834	NNS	denotes	panels
T12155	1835-1837	IN	denotes	in
T12156	1871-1877	VBN	denotes	merged
T12157	1838-1843	WDT	denotes	which
T12158	1844-1848	JJ	denotes	dual
T12159	1858-1866	NNS	denotes	patterns
T12160	1849-1857	NN	denotes	staining
T12161	1867-1870	VBP	denotes	are
T12162	1877-1878	.	denotes	.
T12163	1878-1952	sentence	denotes	Note that (H) and (I) are at lower magnification to show multiple nuclei.
T12164	1879-1883	VB	denotes	Note
T12165	1884-1888	IN	denotes	that
T12166	1901-1904	VBP	denotes	are
T12167	1889-1890	-LRB-	denotes	(
T12168	1890-1891	NN	denotes	H
T12169	1891-1892	-RRB-	denotes	)
T12170	1893-1896	CC	denotes	and
T12171	1897-1898	-LRB-	denotes	(
T12172	1898-1899	NN	denotes	I
T12173	1899-1900	-RRB-	denotes	)
T12174	1905-1907	IN	denotes	at
T12175	1908-1913	JJR	denotes	lower
T12176	1914-1927	NN	denotes	magnification
T12177	1928-1930	TO	denotes	to
T12178	1931-1935	VB	denotes	show
T12179	1936-1944	JJ	denotes	multiple
T12180	1945-1951	NNS	denotes	nuclei
T12181	1951-1952	.	denotes	.
T5198	1478-1488	NN	denotes	vertebrate
T5199	1489-1497	JJ	denotes	specific
T5200	1488-1489	HYPH	denotes	-
T12126	1642-1659	JJ	denotes	Immunocytological
T12127	1660-1668	NN	denotes	Analysis
T12128	1669-1671	IN	denotes	of
T12129	1672-1678	NN	denotes	Trip13
T12130	1688-1695	NNS	denotes	Mutants
T12131	1679-1687	NN	denotes	Compound
T12132	1695-1789	sentence	denotes	Surface-spread chromosomes were immunolabeled with the indicated antibodies and fluorophores.
T12133	1696-1703	NN	denotes	Surface
T12134	1704-1710	NN	denotes	spread
T12135	1703-1704	HYPH	denotes	-
T12136	1711-1722	NNS	denotes	chromosomes
T12137	1728-1741	VBN	denotes	immunolabeled
T12138	1723-1727	VBD	denotes	were
T12139	1742-1746	IN	denotes	with
T12140	1747-1750	DT	denotes	the
T12141	1761-1771	NNS	denotes	antibodies
T12142	1751-1760	VBN	denotes	indicated
T12143	1772-1775	CC	denotes	and
T12144	1776-1788	NNS	denotes	fluorophores
T12145	1788-1789	.	denotes	.
T12146	1789-1878	sentence	denotes	Genotypes are indicated, as are those panels in which dual staining patterns are merged.
T12147	1790-1799	NNS	denotes	Genotypes
T12148	1804-1813	VBN	denotes	indicated
T5201	1503-1507	RB	denotes	also
T5202	1508-1516	VBN	denotes	required
T5203	1517-1520	IN	denotes	for
T5204	1521-1524	NN	denotes	DSB
T5205	1525-1534	NN	denotes	formation
T5206	1535-1538	CC	denotes	and
T5207	1539-1549	NN	denotes	chromosome
T5208	1550-1558	NN	denotes	synapsis
T5209	1559-1560	-LRB-	denotes	[
T5210	1560-1562	CD	denotes	37
T5211	1562-1563	-RRB-	denotes	]
T5212	1563-1565	,	denotes	,
T5213	1565-1569	IN	denotes	with
T5193	1466-1469	IN	denotes	for
T5194	1470-1474	NN	denotes	Mei1
T5195	1474-1476	,	denotes	,
T5196	1476-1477	DT	denotes	a
T5197	1498-1502	NN	denotes	gene
T5214	1570-1577	JJ	denotes	similar
T5215	1578-1585	NNS	denotes	results
T5216	1586-1587	-LRB-	denotes	(
T5217	1594-1596	NN	denotes	3J
T5218	1587-1593	NN	denotes	Figure
T5219	1597-1600	CC	denotes	and
T5220	1601-1603	NN	denotes	3K
T5221	1603-1604	:	denotes	;
T5222	1605-1619	NN	denotes	immunocytology
T5223	1624-1629	VBN	denotes	shown
T5224	1620-1623	RB	denotes	not
T5225	1629-1630	-RRB-	denotes	)
T5226	1630-1631	.	denotes	.
T5227	1631-1632	sentence	denotes
T5228	1953-1957	sentence	denotes	In y
T5229	1953-1955	JJ	denotes	In
T5230	1956-1957	NN	denotes	y
T5231	1957-1961	sentence	denotes	east
T5232	1957-1958	NN	denotes	e
T5233	1958-1959	NN	denotes	a
T5234	1959-1960	NNS	denotes	s
R3071	T4919	T4920	compound	TRIP13,Deficiency
R3072	T4920	T4921	nsubj	Deficiency,Alleviate
R3073	T4922	T4921	aux	Does,Alleviate
R3074	T4923	T4921	neg	Not,Alleviate
R3075	T4924	T4925	amod	Meiotic,Arrest
R3076	T4925	T4926	compound	Arrest,Phenotypes
R3077	T4926	T4921	dobj	Phenotypes,Alleviate
R3078	T4927	T4926	prep	of,Phenotypes
R3079	T4928	T4927	pobj	Mutants,of
R3080	T4929	T4928	amod	Defective,Mutants
R3081	T4930	T4929	prep	in,Defective
R3082	T4931	T4930	pobj	Synapsis,in
R3083	T4933	T4934	aux	To,determine
R3084	T4934	T4935	advcl	determine,analyzed
R3085	T4936	T4937	mark	if,prevents
R3086	T4937	T4934	ccomp	prevents,determine
R3087	T4938	T4939	compound	TRIP13,deficiency
R3088	T4939	T4937	nsubj	deficiency,prevents
R3089	T4940	T4937	dobj	apoptosis,prevents
R3090	T4941	T4940	acl	triggered,apoptosis
R3091	T4942	T4941	agent	by,triggered
R3092	T4943	T4942	pobj	asynapsis,by
R3093	T4944	T4941	prep	as,triggered
R3094	T4945	T4944	prep	in,as
R3095	T4946	T4947	compound	C.,elegans
R3096	T4947	T4945	pobj	elegans,in
R3097	T4948	T4935	punct	", ",analyzed
R3098	T4949	T4935	nsubj	we,analyzed
R3099	T4950	T4935	dobj	mice,analyzed
R3100	T4951	T4952	dep	that,were
R3101	T4952	T4950	relcl	were,mice
R3102	T4953	T4954	advmod	doubly,mutant
R3103	T4954	T4952	acomp	mutant,were
R3104	T4955	T4954	prep	for,mutant
R3105	T4956	T4955	pobj	Spo11,for
R3106	T4957	T4956	cc	and,Spo11
R3107	T4958	T4956	conj	Trip13,Spo11
R3108	T4959	T4935	punct	.,analyzed
R3109	T4961	T4962	nsubj	SPO11,is
R3110	T4963	T4964	det	a,transesterase
R3111	T4964	T4962	attr	transesterase,is
R3112	T4965	T4966	dep	that,is
R3113	T4966	T4964	relcl	is,transesterase
R3114	T4967	T4966	acomp	essential,is
R3115	T4968	T4967	prep	for,essential
R3116	T4969	T4970	det	the,creation
R3117	T4970	T4968	pobj	creation,for
R3118	T4971	T4970	prep	of,creation
R3119	T4972	T4973	advmod	genetically,programmed
R3120	T4973	T4974	amod	programmed,DSB
R3121	T4974	T4971	pobj	DSB,of
R3122	T4975	T4970	prep	during,creation
R3123	T4976	T4975	pobj	leptonema,during
R3124	T4977	T4976	prep	of,leptonema
R3125	T4978	T4979	amod	many,organisms
R3126	T4979	T4977	pobj	organisms,of
R3127	T4980	T4979	punct	", ",organisms
R3128	T4981	T4979	prep	including,organisms
R3129	T4982	T4981	pobj	mice,including
R3130	T4983	T4984	punct	[,18
R3131	T4984	T4966	parataxis	18,is
R3132	T4985	T4984	punct	],18
R3133	T4986	T4962	punct	.,is
R3134	T4988	T4989	prep	In,have
R3135	T4990	T4991	compound	C.,elegans
R3136	T4991	T4988	pobj	elegans,In
R3137	T4992	T4989	punct	", ",have
R3138	T4993	T4994	nmod	spo,gametes
R3139	T4994	T4989	nsubj	gametes,have
R3140	T4995	T4993	punct	-,spo
R3141	T4996	T4993	nummod	11,spo
R3142	T4997	T4994	compound	mutant,gametes
R3143	T4998	T4999	amod	extensive,asynapsis
R3144	T4999	T4989	dobj	asynapsis,have
R3145	T5000	T4999	punct	", ",asynapsis
R3146	T5001	T5002	dep	which,triggers
R3147	T5002	T4999	relcl	triggers,asynapsis
R3148	T5003	T5004	npadvmod	PCH,dependent
R3149	T5004	T5007	amod	dependent,apoptosis
R3150	T5005	T5003	punct	-,PCH
R3151	T5006	T5003	nummod	2,PCH
R3152	T5007	T5002	dobj	apoptosis,triggers
R3153	T5008	T5007	prep	in,apoptosis
R3154	T5009	T5008	pobj	pachynema,in
R3155	T5010	T5011	punct	[,2
R3156	T5011	T4989	parataxis	2,have
R3157	T5012	T5011	punct	],2
R3158	T5013	T4989	punct	.,have
R3159	T5015	T5016	prep	In,are
R3160	T5017	T5015	pobj	mice,In
R3161	T5018	T5016	punct	", ",are
R3162	T5019	T5020	nmod	Spo11,spermatocytes
R3163	T5020	T5016	nsubj	spermatocytes,are
R3164	T5021	T5019	punct	−,Spo11
R3165	T5022	T5019	punct	/,Spo11
R3166	T5023	T5019	punct	−,Spo11
R3167	T5024	T5025	advmod	severely,defective
R3168	T5025	T5016	acomp	defective,are
R3169	T5026	T5016	prep	in,are
R3170	T5027	T5028	amod	homologous,synapsis
R3171	T5028	T5026	pobj	synapsis,in
R3172	T5029	T5028	compound	chromosome,synapsis
R3173	T5030	T5031	punct	[,35
R3174	T5031	T5016	parataxis	35,are
R3175	T5032	T5031	nummod	34,35
R3176	T5033	T5031	punct	",",35
R3177	T5034	T5031	punct	],35
R3178	T5035	T5016	punct	", ",are
R3179	T5036	T5016	cc	and,are
R3180	T5037	T5016	conj	arrest,are
R3181	T5038	T5037	prep	with,arrest
R3182	T5039	T5038	pobj	chromosomes,with
R3183	T5040	T5037	prep	in,arrest
R3184	T5041	T5042	det	a,state
R3185	T5042	T5040	pobj	state,in
R3186	T5043	T5042	amod	characteristic,state
R3187	T5044	T5043	prep	of,characteristic
R3188	T5045	T5046	det	the,transition
R3189	T5046	T5044	pobj	transition,of
R3190	T5047	T5048	compound	zygotene,pachytene
R3191	T5048	T5046	compound	pachytene,transition
R3192	T5049	T5048	punct	/,pachytene
R3193	T5050	T5051	punct	(,3H
R3194	T5051	T5037	parataxis	3H,arrest
R3195	T5052	T5051	compound	Figure,3H
R3196	T5053	T5051	punct	),3H
R3197	T5054	T5016	punct	.,are
R3198	T5056	T5057	nsubj	Spermatocytes,progressed
R3199	T5058	T5056	prep	in,Spermatocytes
R3200	T5059	T5060	nmod	Trip13Gt,Gt
R3201	T5060	T5062	nmod	Gt,testes
R3202	T5061	T5060	punct	/,Gt
R3203	T5062	T5058	pobj	testes,in
R3204	T5063	T5062	nmod	Spo11,testes
R3205	T5064	T5063	punct	−,Spo11
R3206	T5065	T5063	punct	/,Spo11
R3207	T5066	T5063	punct	−,Spo11
R3208	T5067	T5057	advmod	maximally,progressed
R3209	T5068	T5057	prep	to,progressed
R3210	T5069	T5070	det	that,point
R3211	T5070	T5068	pobj	point,to
R3212	T5071	T5057	prep	before,progressed
R3213	T5072	T5071	pcomp	undergoing,before
R3214	T5073	T5072	dobj	death,undergoing
R3215	T5074	T5075	punct	(,3I
R3216	T5075	T5072	parataxis	3I,undergoing
R3217	T5076	T5075	compound	Figs,3I
R3218	T5077	T5075	punct	),3I
R3219	T5078	T5072	punct	", ",undergoing
R3220	T5079	T5080	advmod	well,before
R3221	T5080	T5072	prep	before,undergoing
R3222	T5081	T5082	det	the,checkpoint
R3223	T5082	T5080	pobj	checkpoint,before
R3224	T5083	T5082	compound	spindle,checkpoint
R3225	T5084	T5085	dep	that,eliminates
R3226	T5085	T5082	relcl	eliminates,checkpoint
R3227	T5086	T5087	compound	achiasmate,spermatocytes
R3228	T5087	T5085	dobj	spermatocytes,eliminates
R3229	T5088	T5089	punct	[,36
R3230	T5089	T5057	parataxis	36,progressed
R3231	T5090	T5089	punct	],36
R3232	T5091	T5057	punct	.,progressed
R3233	T5093	T5094	expl	There,was
R3234	T5095	T5096	det	no,evidence
R3235	T5096	T5094	attr	evidence,was
R3236	T5097	T5096	prep	of,evidence
R3237	T5098	T5099	nmod	metaphase,spermatocytes
R3238	T5099	T5097	pobj	spermatocytes,of
R3239	T5100	T5098	nummod	I,metaphase
R3240	T5101	T5099	cc	or,spermatocytes
R3241	T5102	T5103	amod	postmeiotic,spermatids
R3242	T5103	T5099	conj	spermatids,spermatocytes
R3243	T5104	T5096	prep	in,evidence
R3244	T5105	T5106	det	these,testes
R3245	T5106	T5104	pobj	testes,in
R3246	T5107	T5094	punct	", ",was
R3247	T5108	T5094	prep	unlike,was
R3248	T5109	T5108	pobj	those,unlike
R3249	T5110	T5109	acl	seen,those
R3250	T5111	T5110	prep	in,seen
R3251	T5112	T5113	nmod	Trip13,mutants
R3252	T5113	T5111	pobj	mutants,in
R3253	T5114	T5113	amod	single,mutants
R3254	T5115	T5116	punct	(,3G
R3255	T5116	T5094	parataxis	3G,was
R3256	T5117	T5116	compound	Figure,3G
R3257	T5118	T5116	punct	),3G
R3258	T5119	T5094	punct	.,was
R3259	T5121	T5122	prep	In,disrupted
R3260	T5123	T5121	pobj	contrast,In
R3261	T5124	T5123	prep	to,contrast
R3262	T5125	T5126	det	the,synapsis
R3263	T5126	T5124	pobj	synapsis,to
R3264	T5127	T5126	amod	complete,synapsis
R3265	T5128	T5126	prep	in,synapsis
R3266	T5129	T5130	compound	Trip13Gt,Gt
R3267	T5130	T5132	compound	Gt,pachytene
R3268	T5131	T5130	punct	/,Gt
R3269	T5132	T5133	compound	pachytene,spermatocytes
R3270	T5133	T5128	pobj	spermatocytes,in
R3271	T5134	T5135	punct	(,5A
R3272	T5135	T5126	parataxis	5A,synapsis
R3273	T5136	T5135	compound	Figure,5A
R3274	T5137	T5135	punct	),5A
R3275	T5138	T5126	punct	", ",synapsis
R3276	T5139	T5140	prep	in,is
R3277	T5140	T5126	relcl	is,synapsis
R3278	T5141	T5139	pobj	which,in
R3279	T5142	T5140	nsubj	SPO11,is
R3280	T5143	T5140	acomp	available,is
R3281	T5144	T5140	prep	in,is
R3282	T5145	T5144	pobj	leptonema,in
R3283	T5146	T5147	aux	to,initiate
R3284	T5147	T5140	advcl	initiate,is
R3285	T5148	T5149	punct	(,S2A
R3286	T5149	T5147	parataxis	S2A,initiate
R3287	T5150	T5149	prep	via,S2A
R3288	T5151	T5152	compound	DSB,induction
R3289	T5152	T5150	pobj	induction,via
R3290	T5153	T5149	punct	", ",S2A
R3291	T5154	T5149	compound	Figure,S2A
R3292	T5155	T5149	cc	and,S2A
R3293	T5156	T5149	conj	S2B,S2A
R3294	T5157	T5149	punct	),S2A
R3295	T5158	T5159	det	a,search
R3296	T5159	T5147	dobj	search,initiate
R3297	T5160	T5161	npadvmod	recombination,driven
R3298	T5161	T5159	amod	driven,search
R3299	T5162	T5161	punct	-,driven
R3300	T5163	T5159	compound	homolog,search
R3301	T5164	T5122	punct	", ",disrupted
R3302	T5165	T5166	compound	chromosome,synapsis
R3303	T5166	T5122	nsubjpass	synapsis,disrupted
R3304	T5167	T5166	prep	in,synapsis
R3305	T5168	T5169	advmod	doubly,mutant
R3306	T5169	T5170	amod	mutant,spermatocytes
R3307	T5170	T5167	pobj	spermatocytes,in
R3308	T5171	T5122	auxpass	was,disrupted
R3309	T5172	T5122	advmod	highly,disrupted
R3310	T5173	T5122	prep	as,disrupted
R3311	T5174	T5173	prep	in,as
R3312	T5175	T5176	nmod	Spo11,mutants
R3313	T5176	T5174	pobj	mutants,in
R3314	T5177	T5176	amod	single,mutants
R3315	T5178	T5179	punct	(,5B
R3317	T5180	T5179	compound	Figure,5B
R3346	T5211	T5210	punct	],37
R3347	T5212	T5188	punct	", ",performed
R3348	T5213	T5188	prep	with,performed
R3349	T5214	T5215	amod	similar,results
R3350	T5215	T5213	pobj	results,with
R3351	T5216	T5217	punct	(,3J
R3352	T5217	T5188	parataxis	3J,performed
R3353	T5218	T5217	compound	Figure,3J
R3354	T5219	T5217	cc	and,3J
R3355	T5220	T5217	conj	3K,3J
R3356	T5221	T5217	punct	;,3J
R3357	T5222	T5223	nsubj	immunocytology,shown
R3358	T5223	T5217	ccomp	shown,3J
R3359	T5224	T5223	neg	not,shown
R3360	T5225	T5217	punct	),3J
R3361	T5226	T5188	punct	.,performed
R3362	T5229	T5230	amod	In,y
R3363	T5232	T5233	compound	e,a
R3364	T5233	T5234	compound	a,s
R3365	T5238	T5239	amod	d,e
R3384	T5265	T5266	compound	mouse,SYCP1
R3385	T5266	T5264	nsubj	SYCP1,be
R3386	T5267	T5264	aux	might,be
R3387	T5269	T5270	det	a,equivalent
R3388	T5270	T5264	attr	equivalent,be
R3389	T5271	T5270	amod	functional,equivalent
R3390	T5272	T5270	prep	of,equivalent
R3391	T5273	T5272	pobj	Zip1p,of
R3392	T5274	T5268	punct	", ",be
R3393	T5275	T5276	mark	because,arrest
R3394	T5276	T5268	advcl	arrest,be
R3395	T5277	T5278	compound	Sycp1,spermatocytes
R3396	T5278	T5276	nsubj	spermatocytes,arrest
R3397	T5279	T5278	compound	mutant,spermatocytes
R3398	T5280	T5276	prep	at,arrest
R3399	T5281	T5282	advmod	approximately,point
R3400	T5282	T5280	pobj	point,at
R3401	T5283	T5282	det	the,point
R3402	T5284	T5282	amod	same,point
R3403	T5285	T5282	prep	as,point
R3404	T5286	T5287	compound	Trip13,mutants
R3405	T5287	T5285	pobj	mutants,as
R3406	T5288	T5268	punct	", ",be
R3407	T5289	T5268	expl	there,be
R3408	T5290	T5268	aux	would,be
R3409	T5291	T5292	det	no,opportunity
R3410	T5292	T5268	attr	opportunity,be
R3411	T5293	T5294	aux	to,observe
R3412	T5294	T5292	acl	observe,opportunity
R3413	T5295	T5294	dobj	bypass,observe
R3414	T5296	T5295	prep	of,bypass
R3415	T5297	T5296	pobj	Sycp1,of
R3416	T5298	T5297	punct	−,Sycp1
R3417	T5299	T5297	punct	/,Sycp1
R3418	T5300	T5297	punct	−,Sycp1
R3419	T5301	T5268	punct	.,be
R3420	T5303	T5304	mark	Since,is
R3421	T5304	T5306	advcl	is,suggested
R3422	T5305	T5304	nsubj	Zip2p,is
R3423	T5307	T5304	acomp	present,is
R3424	T5308	T5304	prep	at,is
R3425	T5309	T5308	pobj	sites,at
R3426	T5310	T5309	prep	of,sites
R3427	T5311	T5312	amod	axial,associations
R3428	T5312	T5310	pobj	associations,of
R3429	T5313	T5308	punct	", ",at
R3430	T5314	T5315	advmod	even,in
R3431	T5315	T5308	prep	in,at
R3432	T5316	T5317	compound	zip1,mutants
R3433	T5317	T5315	pobj	mutants,in
R3434	T5318	T5306	punct	", ",suggested
R3435	T5319	T5306	nsubjpass	it,suggested
R3436	T5320	T5306	aux	has,suggested
R3437	T5321	T5306	auxpass	been,suggested
R3438	T5322	T5323	mark	that,promotes
R3439	T5323	T5306	ccomp	promotes,suggested
R3440	T5324	T5323	nsubj	Zip2p,promotes
R3441	T5325	T5323	dobj	initiation,promotes
R3442	T5326	T5325	prep	of,initiation
R3443	T5327	T5328	compound	chromosome,synapsis
R3444	T5328	T5326	pobj	synapsis,of
R3445	T5329	T5330	punct	[,38
R3446	T5330	T5306	parataxis	38,suggested
R3447	T5331	T5330	punct	],38
R3448	T5332	T5306	punct	.,suggested
R3449	T5334	T5335	det	These,observations
R3450	T5335	T5336	nsubj	observations,raise
R3451	T5337	T5338	det	the,possibility
R3452	T5338	T5336	dobj	possibility,raise
R3453	T5339	T5340	mark	that,responds
R3454	T5340	T5338	acl	responds,possibility
R3455	T5341	T5340	prep	in,responds
R3456	T5342	T5341	pobj	yeast,in
R3457	T5343	T5340	punct	", ",responds
R3458	T5344	T5340	nsubj	Pch2p,responds
R3459	T5345	T5340	prep	to,responds
R3460	T5346	T5347	compound	synapsis,polymerization
R3461	T5347	T5345	pobj	polymerization,to
R3462	T5348	T5349	advmod	rather,than
R3463	T5349	T5347	cc	than,polymerization
R3464	T5350	T5347	conj	initiation,polymerization
R3465	T5351	T5336	punct	.,raise
R3466	T5353	T5354	aux	To,test
R3467	T5354	T5355	advcl	test,performed
R3468	T5356	T5354	dobj	this,test
R3469	T5357	T5355	punct	", ",performed
R3470	T5358	T5355	nsubj	we,performed
R3471	T5359	T5360	compound	epistasis,analysis
R3472	T5360	T5355	dobj	analysis,performed
R3473	T5361	T5355	prep	with,performed
R3474	T5362	T5363	det	a,allele
R3475	T5363	T5361	pobj	allele,with
R3476	T5364	T5363	compound	Rec8,allele
R3477	T5365	T5363	punct	(,allele
R3478	T5366	T5363	appos	Rec8Mei8,allele
R3479	T5367	T5366	punct	", ",Rec8Mei8
R3480	T5368	T5366	acl	abbreviated,Rec8Mei8
R3481	T5369	T5368	prep	as,abbreviated
R3482	T5370	T5369	pobj	Rec8,as
R3483	T5371	T5370	punct	−,Rec8
R3484	T5372	T5355	punct	),performed
R3485	T5373	T5355	punct	.,performed
R3486	T5375	T5376	amod	Meiotic,chromosomes
R3487	T5376	T5377	nsubj	chromosomes,undergo
R3488	T5378	T5376	prep	of,chromosomes
R3489	T5379	T5380	compound	Rec8,spermatocytes
R3490	T5380	T5378	pobj	spermatocytes,of
R3491	T5381	T5380	compound	mutant,spermatocytes
R3492	T5382	T5383	amod	apparent,pairing
R3493	T5383	T5377	dobj	pairing,undergo
R3494	T5384	T5383	compound	homolog,pairing
R3495	T5385	T5383	cc	and,pairing
R3496	T5386	T5387	amod	interhomolog,initiation
R3497	T5387	T5383	conj	initiation,pairing
R3498	T5388	T5387	amod	synaptic,initiation
R3499	T5389	T5377	punct	", ",undergo
R3500	T5390	T5377	cc	but,undergo
R3501	T5391	T5377	conj	are,undergo
R3502	T5392	T5391	acomp	defective,are
R3503	T5393	T5392	prep	in,defective
R3504	T5394	T5395	compound	DSB,repair
R3505	T5395	T5393	pobj	repair,in
R3506	T5396	T5391	cc	and,are
R3507	T5397	T5391	conj	fail,are
R3508	T5398	T5399	aux	to,maintain
R3509	T5399	T5397	xcomp	maintain,fail
R3510	T5400	T5399	amod	interhomolog,maintain
R3511	T5401	T5399	dep	synapsis,maintain
R3512	T5402	T5403	punct	[,40
R3513	T5403	T5391	parataxis	40,are
R3514	T5404	T5403	nummod	39,40
R3515	T5405	T5403	punct	",",40
R3516	T5406	T5403	punct	],40
R3517	T5407	T5377	punct	.,undergo
R3518	T5409	T5410	advmod	Rather,appear
R3519	T5411	T5410	punct	", ",appear
R3520	T5412	T5413	compound	sister,chromatids
R3521	T5413	T5410	nsubj	chromatids,appear
R3522	T5414	T5415	aux	to,synapse
R3523	T5415	T5410	xcomp	synapse,appear
R3524	T5416	T5410	cc	and,appear
R3525	T5417	T5418	auxpass	are,bound
R3526	T5418	T5410	conj	bound,appear
R3527	T5419	T5418	prep	by,bound
R3528	T5420	T5419	pobj	SYCP1,by
R3529	T5421	T5418	prep	along,bound
R3530	T5422	T5423	poss	their,axes
R3531	T5423	T5421	pobj	axes,along
R3532	T5424	T5410	punct	.,appear
R3533	T5426	T5427	compound	Rec8,mutants
R3534	T5427	T5428	nsubj	mutants,progress
R3535	T5429	T5428	aux	do,progress
R3536	T5430	T5428	neg	not,progress
R3537	T5431	T5428	prep	to,progress
R3538	T5432	T5431	pobj	diplonema,to
R3539	T5433	T5432	cc	or,diplonema
R3540	T5434	T5432	conj	metaphase,diplonema
R3541	T5435	T5434	nummod	I,metaphase
R3542	T5436	T5428	punct	.,progress
R3543	T5438	T5439	amod	Double,analysis
R3544	T5439	T5441	nsubj	analysis,indicated
R3545	T5440	T5439	compound	mutant,analysis
R3546	T5442	T5443	mark	that,is
R3547	T5443	T5441	ccomp	is,indicated
R3548	T5444	T5443	nsubj	Rec8,is
R3549	T5445	T5443	acomp	epistatic,is
R3550	T5446	T5445	prep	to,epistatic
R3551	T5447	T5446	pobj	Trip13,to
R3552	T5448	T5441	punct	.,indicated
R3553	T5450	T5451	prep	As,resembled
R3554	T5452	T5450	prep	in,As
R3555	T5453	T5454	det	the,experiments
R3556	T5454	T5452	pobj	experiments,in
R3557	T5455	T5454	nmod	Spo11,experiments
R3558	T5456	T5455	cc	and,Spo11
R3559	T5457	T5455	conj	Mei1,Spo11
R3560	T5458	T5451	punct	", ",resembled
R3561	T5459	T5451	nsubj	histology,resembled
R3562	T5460	T5459	prep	of,histology
R3563	T5461	T5460	pobj	testes,of
R3564	T5462	T5461	amod	deficient,testes
R3565	T5463	T5462	prep	for,deficient
R3566	T5464	T5465	preconj	both,REC8
R3567	T5465	T5463	pobj	REC8,for
R3568	T5466	T5465	cc	and,REC8
R3569	T5467	T5465	conj	TRIP13,REC8
R3570	T5468	T5469	det	the,mutant
R3571	T5469	T5451	dobj	mutant,resembled
R3572	T5470	T5469	compound	Rec8,mutant
R3573	T5471	T5451	punct	", ",resembled
R3574	T5472	T5451	prep	with,resembled
R3575	T5473	T5474	det	no,evidence
R3576	T5474	T5472	pobj	evidence,with
R3577	T5475	T5474	prep	of,evidence
R3578	T5476	T5475	pobj	progression,of
R3579	T5477	T5476	prep	to,progression
R3580	T5478	T5477	pobj	metaphase,to
R3581	T5479	T5478	nummod	I,metaphase
R3582	T5480	T5481	dep	that,occurs
R3583	T5481	T5476	relcl	occurs,progression
R3584	T5482	T5481	prep	in,occurs
R3585	T5483	T5484	compound	Trip13Gt,Gt
R3586	T5484	T5486	compound	Gt,mice
R3587	T5485	T5484	punct	/,Gt
R3588	T5486	T5482	pobj	mice,in
R3589	T5487	T5488	punct	(,3L
R3590	T5488	T5451	parataxis	3L,resembled
R3591	T5489	T5488	compound	Figure,3L
R3592	T5490	T5488	cc	and,3L
R3593	T5491	T5488	conj	3M,3L
R3594	T5492	T5488	punct	),3L
R3595	T5493	T5451	punct	.,resembled
R3596	T5495	T5496	amod	Immunocytological,analysis
R3597	T5496	T5497	nsubj	analysis,showed
R3598	T5498	T5496	prep	of,analysis
R3599	T5499	T5500	compound	spread,chromosomes
R3600	T5500	T5498	pobj	chromosomes,of
R3601	T5501	T5502	det	a,failure
R3602	T5502	T5497	dobj	failure,showed
R3603	T5503	T5502	prep	of,failure
R3604	T5504	T5505	amod	homologous,synapsis
R3605	T5505	T5503	pobj	synapsis,of
R3606	T5506	T5505	compound	chromosome,synapsis
R3607	T5507	T5502	prep	in,failure
R3608	T5508	T5509	preconj	both,spermatocytes
R3609	T5509	T5507	pobj	spermatocytes,in
R3610	T5510	T5509	det	the,spermatocytes
R3611	T5511	T5509	nmod	Rec8,spermatocytes
R3612	T5512	T5511	punct	−,Rec8
R3613	T5513	T5511	punct	/,Rec8
R3614	T5514	T5511	punct	−,Rec8
R3615	T5515	T5511	cc	and,Rec8
R3616	T5516	T5517	nmod	Rec8,Gt
R3617	T5517	T5511	conj	Gt,Rec8
R3618	T5518	T5516	punct	−,Rec8
R3619	T5519	T5516	punct	/,Rec8
R3620	T5520	T5516	punct	−,Rec8
R3621	T5521	T5517	compound	Trip13Gt,Gt
R3622	T5522	T5517	punct	/,Gt
R3623	T5523	T5497	punct	", ",showed
R3624	T5524	T5525	mark	as,reported
R3625	T5525	T5497	advcl	reported,showed
R3626	T5526	T5525	advmod	previously,reported
R3627	T5527	T5525	prep	for,reported
R3628	T5528	T5529	compound	Rec8,mutants
R3629	T5529	T5527	pobj	mutants,for
R3630	T5530	T5531	punct	(,5D
R3631	T5531	T5497	parataxis	5D,showed
R3632	T5532	T5531	compound	Figure,5D
R3633	T5533	T5531	cc	and,5D
R3634	T5534	T5531	conj	5E,5D
R3635	T5535	T5531	punct	),5D
R3636	T5536	T5537	punct	[,40
R3637	T5537	T5497	parataxis	40,showed
R3638	T5538	T5537	nummod	39,40
R3639	T5539	T5537	punct	",",40
R3640	T5540	T5537	punct	],40
R3641	T5541	T5497	punct	.,showed
R3642	T5543	T5544	mark	Although,indicate
R3643	T5544	T5547	advcl	indicate,reported
R3644	T5545	T5546	amod	subsequent,reports
R3645	T5546	T5544	nsubj	reports,indicate
R3646	T5548	T5544	advmod	otherwise,indicate
R3647	T5549	T5550	punct	[,12
R3648	T5550	T5544	parataxis	12,indicate
R3649	T5551	T5550	nummod	10,12
R3650	T5552	T5550	punct	",",12
R3651	T5553	T5550	punct	],12
R3652	T5554	T5547	punct	", ",reported
R3653	T5555	T5547	nsubjpass	deletion,reported
R3654	T5556	T5555	prep	of,deletion
R3655	T5557	T5556	pobj	PCH2,of
R3656	T5558	T5555	prep	in,deletion
R3657	T5559	T5558	pobj	yeast,in
R3658	T5560	T5547	auxpass	was,reported
R3659	T5561	T5547	advmod	originally,reported
R3660	T5562	T5563	aux	to,alleviate
R3661	T5563	T5547	xcomp	alleviate,reported
R3662	T5564	T5565	amod	meiotic,arrest
R3663	T5565	T5563	dobj	arrest,alleviate
R3664	T5566	T5565	acl	caused,arrest
R3665	T5567	T5566	agent	by,caused
R3666	T5568	T5567	pobj	deficiency,by
R3667	T5569	T5568	prep	for,deficiency
R3668	T5570	T5571	det	the,homolog
R3669	T5571	T5569	pobj	homolog,for
R3670	T5572	T5573	npadvmod	meiosis,specific
R3671	T5573	T5571	amod	specific,homolog
R3672	T5574	T5573	punct	-,specific
R3673	T5575	T5571	compound	RecA,homolog
R3674	T5576	T5571	appos	DMC1,homolog
R3675	T5577	T5578	punct	[,8
R3676	T5578	T5547	parataxis	8,reported
R3677	T5579	T5578	punct	],8
R3678	T5580	T5547	punct	.,reported
R3679	T5582	T5583	aux	To,investigate
R3680	T5583	T5584	advcl	investigate,constructed
R3681	T5585	T5586	det	this,relationship
R3682	T5586	T5583	dobj	relationship,investigate
R3683	T5587	T5583	prep	in,investigate
R3684	T5588	T5587	pobj	mice,in
R3685	T5589	T5584	punct	", ",constructed
R3686	T5590	T5584	nsubj	we,constructed
R3687	T5591	T5584	dobj	animals,constructed
R3688	T5592	T5593	advmod	doubly,mutant
R3689	T5593	T5591	amod	mutant,animals
R3690	T5594	T5593	prep	for,mutant
R3691	T5595	T5594	pobj	Trip13,for
R3692	T5596	T5595	cc	and,Trip13
R3693	T5597	T5595	conj	Dmc1,Trip13
R3694	T5598	T5584	punct	.,constructed
R3695	T5600	T5601	prep	As,arrested
R3696	T5602	T5600	prep	in,As
R3697	T5603	T5604	nmod	Dmc1,mice
R3698	T5604	T5602	pobj	mice,in
R3699	T5605	T5603	punct	−,Dmc1
R3700	T5606	T5603	punct	/,Dmc1
R3701	T5607	T5603	punct	−,Dmc1
R3702	T5608	T5604	punct	", ",mice
R3703	T5609	T5610	prep	in,undergo
R3704	T5610	T5604	relcl	undergo,mice
R3705	T5611	T5609	pobj	which,in
R3706	T5612	T5610	nsubj	spermatocytes,undergo
R3707	T5613	T5614	amod	meiotic,arrest
R3708	T5614	T5610	dobj	arrest,undergo
R3709	T5615	T5610	prep	from,undergo
R3710	T5616	T5617	amod	defective,repair
R3711	T5617	T5615	pobj	repair,from
R3712	T5618	T5617	compound	DSB,repair
R3713	T5619	T5617	cc	and,repair
R3714	T5620	T5621	amod	failed,synapsis
R3715	T5621	T5617	conj	synapsis,repair
R3716	T5622	T5621	compound	chromosome,synapsis
R3717	T5623	T5624	punct	[,16
R3718	T5624	T5610	parataxis	16,undergo
R3719	T5625	T5624	punct	],16
R3720	T5626	T5601	punct	", ",arrested
R3721	T5627	T5601	nsubjpass	spermatogenesis,arrested
R3722	T5628	T5627	prep	in,spermatogenesis
R3723	T5629	T5630	nmod	Dmc1,testes
R3724	T5630	T5628	pobj	testes,in
R3725	T5631	T5629	punct	−,Dmc1
R3726	T5632	T5629	punct	/,Dmc1
R3727	T5633	T5629	punct	−,Dmc1
R3728	T5634	T5635	compound	Trip13Gt,Gt
R3729	T5635	T5630	compound	Gt,testes
R3730	T5636	T5635	punct	/,Gt
R3731	T5637	T5601	auxpass	was,arrested
R3732	T5638	T5601	advmod	uniformly,arrested
R3733	T5639	T5601	prep	at,arrested
R3734	T5640	T5641	det	the,point
R3735	T5641	T5639	pobj	point,at
R3736	T5642	T5643	advmod	where,contained
R3737	T5643	T5641	relcl	contained,point
R3738	T5644	T5643	nsubj	spermatocytes,contained
R3739	T5645	T5643	dobj	chromatin,contained
R3740	T5646	T5645	amod	characteristic,chromatin
R3741	T5647	T5646	prep	of,characteristic
R3742	T5648	T5649	compound	zygonema,pachynema
R3743	T5649	T5647	pobj	pachynema,of
R3744	T5650	T5649	punct	/,pachynema
R3745	T5651	T5652	punct	(,3N
R3746	T5652	T5601	parataxis	3N,arrested
R3747	T5653	T5652	compound	Figure,3N
R3748	T5654	T5652	punct	),3N
R3749	T5655	T5601	punct	.,arrested
R3750	T5657	T5658	amod	Immunocytological,analysis
R3751	T5658	T5659	nsubj	analysis,indicated
R3752	T5660	T5661	mark	that,had
R3753	T5661	T5659	ccomp	had,indicated
R3754	T5662	T5663	preconj	both,Dmc1
R3755	T5663	T5664	nmod	Dmc1,chromosomes
R3756	T5664	T5661	nsubj	chromosomes,had
R3757	T5665	T5663	punct	−,Dmc1
R3758	T5666	T5663	punct	/,Dmc1
R3759	T5667	T5663	punct	−,Dmc1
R3760	T5668	T5663	cc	and,Dmc1
R3761	T5669	T5670	nmod	Dmc1,Gt
R3762	T5670	T5663	conj	Gt,Dmc1
R3763	T5671	T5669	punct	−,Dmc1
R3764	T5672	T5669	punct	/,Dmc1
R3765	T5673	T5669	punct	−,Dmc1
R3766	T5674	T5670	compound	Trip13Gt,Gt
R3767	T5675	T5670	punct	/,Gt
R3768	T5676	T5677	amod	extensive,asynapsis
R3769	T5677	T5661	dobj	asynapsis,had
R3770	T5678	T5661	prep	compared,had
R3771	T5679	T5678	prep	to,compared
R3772	T5680	T5681	nmod	Trip13Gt,mutants
R3773	T5681	T5679	pobj	mutants,to
R3774	T5682	T5681	amod	single,mutants
R3775	T5683	T5684	punct	(,5H
R3776	T5684	T5661	parataxis	5H,had
R3777	T5685	T5684	nmod	Figure,5H
R3778	T5686	T5684	nmod	5F,5H
R3779	T5687	T5684	punct	–,5H
R3780	T5688	T5684	punct	),5H
R3781	T5689	T5659	punct	", ",indicated
R3782	T5690	T5659	cc	and,indicated
R3783	T5691	T5692	nsubj	all,had
R3784	T5692	T5659	conj	had,indicated
R3785	T5693	T5694	amod	persistent,foci
R3786	T5694	T5692	dobj	foci,had
R3787	T5695	T5696	compound	RAD51,DMC1
R3788	T5696	T5694	compound	DMC1,foci
R3789	T5697	T5696	punct	/,DMC1
R3790	T5698	T5694	cc	and,foci
R3791	T5699	T5700	amod	phosphorylated,H2AX
R3792	T5700	T5694	conj	H2AX,foci
R3793	T5701	T5702	punct	(,5L
R3794	T5702	T5692	parataxis	5L,had
R3795	T5703	T5702	dep	γH2AX,5L
R3796	T5704	T5702	punct	;,5L
R3797	T5705	T5702	nmod	Figure,5L
R3798	T5706	T5702	nmod	5I,5L
R3799	T5707	T5702	punct	–,5L
R3800	T5708	T5702	punct	),5L
R3801	T5709	T5692	punct	", ",had
R3802	T5710	T5692	advcl	confirming,had
R3803	T5711	T5712	mark	that,is
R3804	T5712	T5710	ccomp	is,confirming
R3805	T5713	T5712	nsubj	Dmc1,is
R3806	T5714	T5712	acomp	epistatic,is
R3807	T5715	T5714	prep	to,epistatic
R3808	T5716	T5715	pobj	Trip13,to
R3809	T5717	T5692	punct	.,had
R3810	T5719	T5720	advmod	Doubly,mutant
R3811	T5720	T5721	amod	mutant,females
R3812	T5721	T5722	nsubj	females,had
R3813	T5723	T5724	amod	residual,ovaries
R3814	T5724	T5722	dobj	ovaries,had
R3815	T5725	T5722	punct	", ",had
R3816	T5726	T5722	advcl	phenocopying,had
R3817	T5727	T5728	nmod	Dmc1,mutants
R3818	T5728	T5726	dobj	mutants,phenocopying
R3819	T5729	T5727	punct	−,Dmc1
R3820	T5730	T5727	punct	/,Dmc1
R3821	T5731	T5727	punct	−,Dmc1
R3822	T5732	T5727	cc	and,Dmc1
R3823	T5733	T5734	compound	Trip13Gt,Gt
R3824	T5734	T5727	conj	Gt,Dmc1
R3825	T5735	T5734	punct	/,Gt
R3826	T5736	T5728	amod	single,mutants
R3827	T5737	T5738	punct	(,data
R3828	T5738	T5722	meta	data,had
R3829	T5739	T5738	amod	unpublished,data
R3830	T5740	T5738	punct	),data
R3831	T5741	T5722	punct	.,had
R8251	T12126	T12127	amod	Immunocytological,Analysis
R8252	T12128	T12127	prep	of,Analysis
R8253	T12129	T12130	compound	Trip13,Mutants
R8254	T12130	T12128	pobj	Mutants,of
R8255	T12131	T12130	compound	Compound,Mutants
R8256	T12133	T12134	compound	Surface,spread
R8257	T12134	T12136	compound	spread,chromosomes
R8258	T12135	T12134	punct	-,spread
R8259	T12136	T12137	nsubjpass	chromosomes,immunolabeled
R8260	T12138	T12137	auxpass	were,immunolabeled
R8261	T12139	T12137	prep	with,immunolabeled
R8262	T12140	T12141	det	the,antibodies
R8263	T12141	T12139	pobj	antibodies,with
R8264	T12142	T12141	amod	indicated,antibodies
R8265	T12143	T12141	cc	and,antibodies
R8266	T12144	T12141	conj	fluorophores,antibodies
R8267	T12145	T12137	punct	.,immunolabeled
R8268	T12147	T12148	nsubjpass	Genotypes,indicated
R8269	T12149	T12148	auxpass	are,indicated
R8270	T12150	T12148	punct	", ",indicated
R8271	T12151	T12152	mark	as,are
R8272	T12152	T12148	advcl	are,indicated
R8273	T12153	T12154	det	those,panels
R8274	T12154	T12152	nsubj	panels,are
R8275	T12155	T12156	prep	in,merged
R8276	T12156	T12154	relcl	merged,panels
R8277	T12157	T12155	pobj	which,in
R8278	T12158	T12159	amod	dual,patterns
R8279	T12159	T12156	nsubjpass	patterns,merged
R8280	T12160	T12159	compound	staining,patterns
R8281	T12161	T12156	auxpass	are,merged
R8282	T12162	T12148	punct	.,indicated
R8283	T12165	T12166	mark	that,are
R8284	T12166	T12164	ccomp	are,Note
R8285	T12167	T12168	punct	(,H
R8286	T12168	T12166	nsubj	H,are
R8287	T12169	T12168	punct	),H
R8288	T12170	T12168	cc	and,H
R8289	T12171	T12172	punct	(,I
R8290	T12172	T12168	conj	I,H
R8291	T12173	T12172	punct	),I
R8292	T12174	T12166	prep	at,are
R8293	T12175	T12176	amod	lower,magnification
R8294	T12176	T12174	pobj	magnification,at
R8295	T12177	T12178	aux	to,show
R8296	T12178	T12166	advcl	show,are
R8297	T12179	T12180	amod	multiple,nuclei
R8298	T12180	T12178	dobj	nuclei,show
R8299	T12181	T12164	punct	.,Note
R3316	T5179	T5122	parataxis	5B,disrupted
R3318	T5181	T5179	cc	and,5B
R3319	T5182	T5179	conj	5C,5B
R3320	T5183	T5179	punct	),5B
R3321	T5184	T5122	punct	.,disrupted
R3322	T5186	T5187	amod	Identical,studies
R3323	T5187	T5188	nsubjpass	studies,performed
R3324	T5189	T5188	auxpass	were,performed
R3325	T5190	T5188	prep	with,performed
R3326	T5191	T5190	pobj	mice,with
R3327	T5192	T5191	amod	deficient,mice
R3328	T5193	T5192	prep	for,deficient
R3329	T5194	T5193	pobj	Mei1,for
R3330	T5195	T5194	punct	", ",Mei1
R3331	T5196	T5197	det	a,gene
R3332	T5197	T5194	appos	gene,Mei1
R3333	T5198	T5199	npadvmod	vertebrate,specific
R3334	T5199	T5197	amod	specific,gene
R3335	T5200	T5199	punct	-,specific
R3336	T5201	T5202	advmod	also,required
R3337	T5202	T5197	acl	required,gene
R3338	T5203	T5202	prep	for,required
R3339	T5204	T5205	compound	DSB,formation
R3340	T5205	T5203	pobj	formation,for
R3341	T5206	T5205	cc	and,formation
R3342	T5207	T5208	compound	chromosome,synapsis
R3343	T5208	T5205	conj	synapsis,formation
R3344	T5209	T5210	punct	[,37
R3345	T5210	T5188	parataxis	37,performed
R3366	T5241	T5242	amod	le,tion
R3367	T5247	T5246	pobj	PCH2,f
R3368	T5248	T5249	det	the,arrest
R3369	T5249	T5245	dobj	arrest,alleviates
R3370	T5250	T5249	compound	pachytene,arrest
R3371	T5251	T5249	acl	caused,arrest
R3372	T5252	T5251	agent	by,caused
R3373	T5253	T5254	amod	asynaptic,zip1
R3374	T5254	T5252	pobj	zip1,by
R3375	T5255	T5254	compound	mutants,zip1
R3376	T5256	T5254	cc	and,zip1
R3377	T5257	T5254	conj	zip2,zip1
R3378	T5258	T5259	punct	[,8
R3379	T5259	T5245	parataxis	8,alleviates
R3380	T5260	T5259	punct	],8
R3381	T5261	T5245	punct	.,alleviates
R3382	T5263	T5264	mark	Although,be
R3383	T5264	T5268	advcl	be,be

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T4578	0-6	PR:000016672	denotes	TRIP13
T4579	37-44	GO:0007126	denotes	Meiotic
T4580	87-95	GO:0007129	denotes	Synapsis
T4581	112-118	PR:000016672	denotes	TRIP13
T4582	139-148	GO:0006915	denotes	apoptosis
T4583	163-171	GO:0007129	denotes	synapsis
T4584	178-188	NCBITaxon:6239	denotes	C. elegans
T4585	202-206	NCBITaxon:10088	denotes	mice
T4586	235-240	PR:000015553	denotes	Spo11
T4587	245-251	PR:000016672	denotes	Trip13
T4588	253-258	PR:000015553	denotes	SPO11
T4589	316-327	SO:0000704	denotes	genetically
T4590	350-359	GO:0000237	denotes	leptonema
T4591	368-377	NCBITaxon:1	denotes	organisms
T4592	389-393	NCBITaxon:10088	denotes	mice
T4593	403-413	NCBITaxon:6239	denotes	C. elegans
T4594	415-421	PR:Q22236	denotes	spo-11
T4595	429-436	CL:0000300	denotes	gametes
T4596	453-461	GO:0007129	denotes	synapsis
T4597	478-483	PR:P38126	denotes	PCH-2
T4598	494-503	GO:0006915	denotes	apoptosis
T4599	507-516	GO:0000239	denotes	pachynema
T4600	525-529	NCBITaxon:10088	denotes	mice
T4601	531-536	PR:000015553	denotes	Spo11
T4602	541-554	CL:0000017	denotes	spermatocytes
T4603	581-611	GO:0007129	denotes	homologous chromosome synapsis
T4604	682-690	GO:0000238	denotes	zygotene
T4605	691-700	GO:0000239	denotes	pachytene
T4606	725-738	CL:0000017	denotes	Spermatocytes
T4607	742-748	PR:000016672	denotes	Trip13
T4608	754-759	PR:000015553	denotes	Spo11
T4609	764-770	UBERON:0000473	denotes	testes
T4610	824-829	GO:0016265	denotes	death
T4611	857-864	GO:0005819	denotes	spindle
T4612	857-875	GO:0031577	denotes	spindle checkpoint
T4613	893-902	GO:0005712	denotes	chiasmate
T4614	903-916	CL:0000017	denotes	spermatocytes
T4615	948-959	GO:0007132	denotes	metaphase I
T4616	960-973	CL:0000017	denotes	spermatocytes
T4617	981-988	GO:0007126	denotes	meiotic
T4618	989-999	CL:0000018	denotes	spermatids
T4619	1009-1015	UBERON:0000473	denotes	testes
T4620	1038-1044	PR:000016672	denotes	Trip13
T4621	1101-1109	GO:0007129	denotes	synapsis
T4622	1113-1119	PR:000016672	denotes	Trip13
T4623	1125-1134	GO:0000239	denotes	pachytene
T4624	1135-1148	CL:0000017	denotes	spermatocytes
T4625	1171-1176	PR:000015553	denotes	SPO11
T4626	1193-1202	GO:0000237	denotes	leptonema
T4627	1294-1313	GO:0007129	denotes	chromosome synapsis
T4628	1331-1344	CL:0000017	denotes	spermatocytes
T4629	1372-1377	PR:000015553	denotes	Spo11
T4630	1451-1455	NCBITaxon:10088	denotes	mice
T4631	1470-1474	PR:000031227	denotes	Mei1
T4632	1478-1488	NCBITaxon:7742	denotes	vertebrate
T4633	1498-1502	SO:0000704	denotes	gene
T4634	1539-1558	GO:0007129	denotes	chromosome synapsis
T4635	1975-1979	PR:P38126	denotes	PCH2
T4636	1995-2004	GO:0000239	denotes	pachytene
T4637	2023-2031	GO:0007129	denotes	synaptic
T4638	2040-2044	PR:P31111	denotes	zip1
T4639	2049-2053	PR:P53061	denotes	zip2
T4640	2068-2073	NCBITaxon:10088	denotes	mouse
T4641	2074-2079	PR:000015862	denotes	SYCP1
T4642	2131-2136	PR:000015862	denotes	Sycp1
T4643	2144-2157	CL:0000017	denotes	spermatocytes
T4644	2200-2206	PR:000016672	denotes	Trip13
T4645	2267-2272	PR:000015862	denotes	Sycp1
T4646	2341-2345	PR:P31111	denotes	zip1
T4647	2411-2430	GO:0007129	denotes	chromosome synapsis
T4648	2511-2519	GO:0007129	denotes	synapsis
T4649	2520-2534	MOP:0000629	denotes	polymerization
T4650	2612-2616	PR:000013858	denotes	Rec8
T4651	2617-2623	SO:0001023	denotes	allele
T4652	2625-2629	PR:000013858	denotes	Rec8
T4653	2650-2654	PR:000013858	denotes	Rec8
T4654	2659-2666	GO:0007126	denotes	Meiotic
T4655	2682-2686	PR:000013858	denotes	Rec8
T4656	2694-2707	CL:0000017	denotes	spermatocytes
T4657	2745-2766	GO:0007129	denotes	interhomolog synaptic
T4658	2800-2810	GO:0006302	denotes	DSB repair
T4659	2832-2853	GO:0007129	denotes	interhomolog synapsis
T4660	2899-2906	GO:0007129	denotes	synapse
T4661	2924-2929	PR:000015862	denotes	SYCP1
T4662	2948-2952	PR:000013858	denotes	Rec8
T4663	2980-2989	GO:0000240	denotes	diplonema
T4664	2993-3004	GO:0007132	denotes	metaphase I
T4665	3044-3048	PR:000013858	denotes	Rec8
T4666	3065-3071	PR:000016672	denotes	Trip13
T4667	3083-3088	PR:000015553	denotes	Spo11
T4668	3093-3097	PR:000031227	denotes	Mei1
T4669	3124-3130	UBERON:0000473	denotes	testes
T4670	3150-3154	PR:000013858	denotes	REC8
T4671	3159-3165	PR:000016672	denotes	TRIP13
T4672	3180-3184	PR:000013858	denotes	Rec8
T4673	3228-3239	GO:0007132	denotes	metaphase I
T4674	3255-3261	PR:000016672	denotes	Trip13
T4675	3267-3271	NCBITaxon:10088	denotes	mice
T4676	3361-3391	GO:0007129	denotes	homologous chromosome synapsis
T4677	3404-3408	PR:000013858	denotes	Rec8
T4678	3417-3421	PR:000013858	denotes	Rec8
T4679	3426-3432	PR:000016672	denotes	Trip13
T4680	3438-3451	CL:0000017	denotes	spermatocytes
T4681	3480-3484	PR:000013858	denotes	Rec8
T4682	3589-3593	PR:P38126	denotes	PCH2
T4683	3640-3647	GO:0007126	denotes	meiotic
T4684	3684-3691	GO:0007126	denotes	meiosis
T4685	3701-3705	PR:000023696	denotes	RecA
T4686	3706-3713	SO:0000853	denotes	homolog
T4687	3714-3718	PR:000006536	denotes	DMC1
T4688	3760-3764	NCBITaxon:10088	denotes	mice
T4689	3781-3788	NCBITaxon:33208	denotes	animals
T4690	3807-3813	PR:000016672	denotes	Trip13
T4691	3818-3822	PR:000006536	denotes	Dmc1
T4692	3830-3834	PR:000006536	denotes	Dmc1
T4693	3839-3843	NCBITaxon:10088	denotes	mice
T4694	3854-3867	CL:0000017	denotes	spermatocytes
T4695	3876-3883	GO:0007126	denotes	meiotic
T4696	3906-3916	GO:0006302	denotes	DSB repair
T4697	3928-3947	GO:0007129	denotes	chromosome synapsis
T4698	3954-3969	GO:0007283	denotes	spermatogenesis
T4699	3973-3977	PR:000006536	denotes	Dmc1
T4700	3982-3988	PR:000016672	denotes	Trip13
T4701	3994-4000	UBERON:0000473	denotes	testes
T4702	4043-4056	CL:0000017	denotes	spermatocytes
T4703	4067-4076	GO:0000785	denotes	chromatin
T4704	4095-4103	GO:0000238	denotes	zygonema
T4705	4104-4113	GO:0000239	denotes	pachynema
T4706	4174-4178	PR:000006536	denotes	Dmc1
T4707	4187-4191	PR:000006536	denotes	Dmc1
T4708	4196-4202	PR:000016672	denotes	Trip13
T4709	4235-4243	GO:0007129	denotes	synapsis
T4710	4256-4262	PR:000016672	denotes	Trip13
T4711	4319-4324	PR:000013672	denotes	RAD51
T4712	4325-4329	PR:000006536	denotes	DMC1
T4713	4354-4358	PR:000008418	denotes	H2AX
T4714	4398-4402	PR:000006536	denotes	Dmc1
T4715	4419-4425	PR:000016672	denotes	Trip13
T4716	4462-4469	UBERON:0000992	denotes	ovaries
T4717	4484-4488	PR:000006536	denotes	Dmc1
T4718	4497-4503	PR:000016672	denotes	Trip13
T12115	1672-1678	PR:000016672	denotes	Trip13
T12116	1761-1771	GO:0042571	denotes	antibodies
T12117	1776-1788	CHEBI:51217	denotes	fluorophores
T12118	1945-1951	GO:0005634	denotes	nuclei

2_test

Id	Subject	Object	Predicate	Lexical cue
17696610-11242108-85497914	395-397	11242108	denotes	18
17696610-16339446-85497915	518-519	16339446	denotes	2
17696610-11106739-85497916	613-615	11106739	denotes	34
17696610-11106738-85497917	616-618	11106738	denotes	35
17696610-11686299-85497918	918-920	11686299	denotes	36
17696610-14668445-85497919	1560-1562	14668445	denotes	37
17696610-10319812-85497920	2055-2056	10319812	denotes	8
17696610-9590170-85497921	2432-2434	9590170	denotes	38
17696610-15515002-85497922	2855-2857	15515002	denotes	39
17696610-15935783-85497923	2858-2860	15935783	denotes	40
17696610-15515002-85497924	3513-3515	15515002	denotes	39
17696610-15935783-85497925	3516-3518	15935783	denotes	40
17696610-16179256-85497926	3569-3571	16179256	denotes	10
17696610-17174924-85497927	3572-3574	17174924	denotes	12
17696610-10319812-85497928	3720-3721	10319812	denotes	8
17696610-9660953-85497929	3949-3951	9660953	denotes	16
T61286	395-397	11242108	denotes	18
T89712	518-519	16339446	denotes	2
T45258	613-615	11106739	denotes	34
T41168	616-618	11106738	denotes	35
T50334	918-920	11686299	denotes	36
T60577	1560-1562	14668445	denotes	37
T42650	2055-2056	10319812	denotes	8
T75874	2432-2434	9590170	denotes	38
T52656	2855-2857	15515002	denotes	39
T5593	2858-2860	15935783	denotes	40
T19680	3513-3515	15515002	denotes	39
T88762	3516-3518	15935783	denotes	40
T34015	3569-3571	16179256	denotes	10
T8585	3572-3574	17174924	denotes	12
T33359	3720-3721	10319812	denotes	8
T76256	3949-3951	9660953	denotes	16

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T4719	0-6	PR_EXT:000016672	denotes	TRIP13
T4720	37-44	GO:0007126	denotes	Meiotic
T4721	66-73	SO_EXT:sequence_altered_entity	denotes	Mutants
T4722	87-95	GO:0007129	denotes	Synapsis
T4723	112-118	PR_EXT:000016672	denotes	TRIP13
T4724	139-148	GO:0006915	denotes	apoptosis
T4725	163-171	GO:0007129	denotes	synapsis
T4726	178-188	NCBITaxon:6239	denotes	C. elegans
T4727	202-206	NCBITaxon:10088	denotes	mice
T4728	224-230	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4729	235-240	PR_EXT:000015553	denotes	Spo11
T4730	245-251	PR_EXT:000016672	denotes	Trip13
T4731	253-258	PR_EXT:000015553	denotes	SPO11
T4732	316-327	SO_EXT:0000704	denotes	genetically
T4733	350-359	GO:0000237	denotes	leptonema
T4734	368-377	NCBITaxon:1	denotes	organisms
T4735	389-393	NCBITaxon:10088	denotes	mice
T4736	403-413	NCBITaxon:6239	denotes	C. elegans
T4737	415-421	PR_EXT:Q22236	denotes	spo-11
T4738	422-428	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4739	429-436	CL:0000300	denotes	gametes
T4740	453-461	GO:0007129	denotes	synapsis
T4741	478-483	PR_EXT:P38126	denotes	PCH-2
T4742	494-503	GO:0006915	denotes	apoptosis
T4743	507-516	GO:0000239	denotes	pachynema
T4744	525-529	NCBITaxon:10088	denotes	mice
T4745	531-536	PR_EXT:000015553	denotes	Spo11
T4746	537-538	SO_EXT:sequence_nullness_or_absence	denotes	−
T4747	539-540	SO_EXT:sequence_nullness_or_absence	denotes	−
T4748	541-554	CL:0000017	denotes	spermatocytes
T4749	581-611	GO:0007129	denotes	homologous chromosome synapsis
T4750	592-602	GO_SO_EXT:chromosome	denotes	chromosome
T4751	637-648	GO_SO_EXT:chromosome	denotes	chromosomes
T4752	682-690	GO:0000238	denotes	zygotene
T4753	691-700	GO:0000239	denotes	pachytene
T4754	725-738	CL:0000017	denotes	Spermatocytes
T4755	742-748	PR_EXT:000016672	denotes	Trip13
T4756	754-759	PR_EXT:000015553	denotes	Spo11
T4757	760-761	SO_EXT:sequence_nullness_or_absence	denotes	−
T4758	762-763	SO_EXT:sequence_nullness_or_absence	denotes	−
T4759	764-770	UBERON:0000473	denotes	testes
T4760	824-829	GO:0016265	denotes	death
T4761	857-864	GO:0005819	denotes	spindle
T4762	857-875	GO:0031577	denotes	spindle checkpoint
T4763	881-891	GO_EXT:killing	denotes	eliminates
T4764	893-902	GO:0005712	denotes	chiasmate
T4765	903-916	CL:0000017	denotes	spermatocytes
T4766	948-959	GO:0007132	denotes	metaphase I
T4767	960-973	CL:0000017	denotes	spermatocytes
T4768	981-988	GO:0007126	denotes	meiotic
T4769	989-999	CL:0000018	denotes	spermatids
T4770	1009-1015	UBERON:0000473	denotes	testes
T4771	1038-1044	PR_EXT:000016672	denotes	Trip13
T4772	1052-1059	SO_EXT:sequence_altered_entity	denotes	mutants
T4773	1101-1109	GO:0007129	denotes	synapsis
T4774	1113-1119	PR_EXT:000016672	denotes	Trip13
T4775	1125-1134	GO:0000239	denotes	pachytene
T4776	1135-1148	CL:0000017	denotes	spermatocytes
T4777	1171-1176	PR_EXT:000015553	denotes	SPO11
T4778	1193-1202	GO:0000237	denotes	leptonema
T4779	1257-1270	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T4780	1294-1304	GO_SO_EXT:chromosome	denotes	chromosome
T4781	1294-1313	GO:0007129	denotes	chromosome synapsis
T4782	1324-1330	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4783	1331-1344	CL:0000017	denotes	spermatocytes
T4792	1959-1960	GO_SO_EXT:chromosome	denotes	s
T4793	1975-1979	PR_EXT:P38126	denotes	PCH2
T4794	1995-2004	GO:0000239	denotes	pachytene
T4795	2023-2031	GO:0007129	denotes	synaptic
T4796	2032-2039	SO_EXT:sequence_altered_entity	denotes	mutants
T4797	2040-2044	PR_EXT:P31111	denotes	zip1
T4798	2049-2053	PR_EXT:P53061	denotes	zip2
T4799	2068-2073	NCBITaxon:10088	denotes	mouse
T4800	2074-2079	PR_EXT:000015862	denotes	SYCP1
T4801	2131-2136	PR_EXT:000015862	denotes	Sycp1
T4802	2137-2143	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4803	2144-2157	CL:0000017	denotes	spermatocytes
T4804	2200-2206	PR_EXT:000016672	denotes	Trip13
T4805	2207-2214	SO_EXT:sequence_altered_entity	denotes	mutants
T4806	2267-2272	PR_EXT:000015862	denotes	Sycp1
T4807	2273-2274	SO_EXT:sequence_nullness_or_absence	denotes	−
T4808	2275-2276	SO_EXT:sequence_nullness_or_absence	denotes	−
T4809	2341-2345	PR_EXT:P31111	denotes	zip1
T4810	2346-2353	SO_EXT:sequence_altered_entity	denotes	mutants
T4811	2411-2421	GO_SO_EXT:chromosome	denotes	chromosome
T4812	2411-2430	GO:0007129	denotes	chromosome synapsis
T4813	2486-2491	NCBITaxon_EXT:yeast	denotes	yeast
T4814	2499-2507	GO_EXT:reaction_or_response	denotes	responds
T4815	2511-2519	GO:0007129	denotes	synapsis
T4816	2520-2534	MOP:0000629	denotes	polymerization
T4817	2612-2616	PR_EXT:000013858	denotes	Rec8
T4818	2617-2623	SO_EXT:0001023	denotes	allele
T4819	2625-2629	PR_EXT:000013858	denotes	Rec8
T4820	2650-2654	PR_EXT:000013858	denotes	Rec8
T4821	2659-2666	GO:0007126	denotes	Meiotic
T4822	2667-2678	GO_SO_EXT:chromosome	denotes	chromosomes
T4823	2682-2686	PR_EXT:000013858	denotes	Rec8
T4824	2687-2693	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4825	2694-2707	CL:0000017	denotes	spermatocytes
T4826	2745-2766	GO:0007129	denotes	interhomolog synaptic
T4827	2800-2810	GO:0006302	denotes	DSB repair
T4828	2832-2853	GO:0007129	denotes	interhomolog synapsis
T4829	2899-2906	GO:0007129	denotes	synapse
T4830	2915-2920	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bound
T4831	2924-2929	PR_EXT:000015862	denotes	SYCP1
T4832	2948-2952	PR_EXT:000013858	denotes	Rec8
T4833	2953-2960	SO_EXT:sequence_altered_entity	denotes	mutants
T4834	2980-2989	GO:0000240	denotes	diplonema
T4835	2993-3004	GO:0007132	denotes	metaphase I
T4836	3013-3019	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4837	3044-3048	PR_EXT:000013858	denotes	Rec8
T4838	3065-3071	PR_EXT:000016672	denotes	Trip13
T4839	3083-3088	PR_EXT:000015553	denotes	Spo11
T4840	3093-3097	PR_EXT:000031227	denotes	Mei1
T4841	3124-3130	UBERON:0000473	denotes	testes
T4842	3150-3154	PR_EXT:000013858	denotes	REC8
T4843	3159-3165	PR_EXT:000016672	denotes	TRIP13
T4844	3180-3184	PR_EXT:000013858	denotes	Rec8
T4845	3185-3191	SO_EXT:sequence_altered_entity	denotes	mutant
T4846	3228-3239	GO:0007132	denotes	metaphase I
T4847	3255-3261	PR_EXT:000016672	denotes	Trip13
T4848	3267-3271	NCBITaxon:10088	denotes	mice
T4849	3329-3340	GO_SO_EXT:chromosome	denotes	chromosomes
T4850	3361-3391	GO:0007129	denotes	homologous chromosome synapsis
T4851	3372-3382	GO_SO_EXT:chromosome	denotes	chromosome
T4852	3404-3408	PR_EXT:000013858	denotes	Rec8
T4853	3409-3410	SO_EXT:sequence_nullness_or_absence	denotes	−
T4854	3411-3412	SO_EXT:sequence_nullness_or_absence	denotes	−
T4855	3417-3421	PR_EXT:000013858	denotes	Rec8
T4856	3422-3423	SO_EXT:sequence_nullness_or_absence	denotes	−
T4857	3424-3425	SO_EXT:sequence_nullness_or_absence	denotes	−
T4858	3426-3432	PR_EXT:000016672	denotes	Trip13
T4859	3438-3451	CL:0000017	denotes	spermatocytes
T4860	3480-3484	PR_EXT:000013858	denotes	Rec8
T4861	3485-3492	SO_EXT:sequence_altered_entity	denotes	mutants
T4862	3577-3585	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4863	3589-3593	PR_EXT:P38126	denotes	PCH2
T4864	3597-3602	NCBITaxon_EXT:yeast	denotes	yeast
T4865	3640-3647	GO:0007126	denotes	meiotic
T4866	3684-3691	GO:0007126	denotes	meiosis
T4867	3701-3705	PR_EXT:000023696	denotes	RecA
T4868	3706-3713	SO_EXT:0000853	denotes	homolog
T4869	3714-3718	PR_EXT:000006536	denotes	DMC1
T4870	3760-3764	NCBITaxon:10088	denotes	mice
T4871	3781-3788	NCBITaxon:33208	denotes	animals
T4872	3796-3802	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4873	3807-3813	PR_EXT:000016672	denotes	Trip13
T4874	3818-3822	PR_EXT:000006536	denotes	Dmc1
T4875	3830-3834	PR_EXT:000006536	denotes	Dmc1
T4876	3835-3836	SO_EXT:sequence_nullness_or_absence	denotes	−
T4877	3837-3838	SO_EXT:sequence_nullness_or_absence	denotes	−
T4878	3839-3843	NCBITaxon:10088	denotes	mice
T4879	3854-3867	CL:0000017	denotes	spermatocytes
T4880	3876-3883	GO:0007126	denotes	meiotic
T4881	3906-3916	GO:0006302	denotes	DSB repair
T4882	3928-3938	GO_SO_EXT:chromosome	denotes	chromosome
T4883	3928-3947	GO:0007129	denotes	chromosome synapsis
T4884	3954-3969	GO:0007283	denotes	spermatogenesis
T4885	3973-3977	PR_EXT:000006536	denotes	Dmc1
T4886	3978-3979	SO_EXT:sequence_nullness_or_absence	denotes	−
T4887	3980-3981	SO_EXT:sequence_nullness_or_absence	denotes	−
T4888	3982-3988	PR_EXT:000016672	denotes	Trip13
T4889	3994-4000	UBERON:0000473	denotes	testes
T4890	4043-4056	CL:0000017	denotes	spermatocytes
T4891	4067-4076	GO:0000785	denotes	chromatin
T4892	4095-4103	GO:0000238	denotes	zygonema
T4893	4104-4113	GO:0000239	denotes	pachynema
T4894	4174-4178	PR_EXT:000006536	denotes	Dmc1
T4895	4179-4180	SO_EXT:sequence_nullness_or_absence	denotes	−
T4896	4181-4182	SO_EXT:sequence_nullness_or_absence	denotes	−
T4897	4187-4191	PR_EXT:000006536	denotes	Dmc1
T4898	4192-4193	SO_EXT:sequence_nullness_or_absence	denotes	−
T4899	4194-4195	SO_EXT:sequence_nullness_or_absence	denotes	−
T4900	4196-4202	PR_EXT:000016672	denotes	Trip13
T4901	4208-4219	GO_SO_EXT:chromosome	denotes	chromosomes
T4902	4235-4243	GO:0007129	denotes	synapsis
T4903	4256-4262	PR_EXT:000016672	denotes	Trip13
T4904	4272-4279	SO_EXT:sequence_altered_entity	denotes	mutants
T4905	4319-4324	PR_EXT:000013672	denotes	RAD51
T4906	4325-4329	PR_EXT:000006536	denotes	DMC1
T4907	4339-4353	GO_PATO_EXT:phosphorylation_process_or_quality	denotes	phosphorylated
T4908	4354-4358	PR_EXT:000008418	denotes	H2AX
T4909	4398-4402	PR_EXT:000006536	denotes	Dmc1
T4910	4419-4425	PR_EXT:000016672	denotes	Trip13
T4911	4434-4440	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4912	4441-4448	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T4913	4462-4469	UBERON:0000992	denotes	ovaries
T4914	4484-4488	PR_EXT:000006536	denotes	Dmc1
T4915	4489-4490	SO_EXT:sequence_nullness_or_absence	denotes	−
T4916	4491-4492	SO_EXT:sequence_nullness_or_absence	denotes	−
T4917	4497-4503	PR_EXT:000016672	denotes	Trip13
T4918	4516-4523	SO_EXT:sequence_altered_entity	denotes	mutants
T12119	1672-1678	PR_EXT:000016672	denotes	Trip13
T12120	1688-1695	SO_EXT:sequence_altered_entity	denotes	Mutants
T12121	1711-1722	GO_SO_EXT:chromosome	denotes	chromosomes
T12122	1761-1771	GO:0042571	denotes	antibodies
T12123	1776-1788	CHEBI_EXT:51217	denotes	fluorophores
T12124	1790-1799	SO_EXT:genotype_or_entity_with_genotype	denotes	Genotypes
T12125	1945-1951	GO:0005634	denotes	nuclei
T4786	1451-1455	NCBITaxon:10088	denotes	mice
T4784	1372-1377	PR_EXT:000015553	denotes	Spo11
T4785	1385-1392	SO_EXT:sequence_altered_entity	denotes	mutants
T4787	1470-1474	PR_EXT:000031227	denotes	Mei1
T4788	1478-1488	NCBITaxon:7742	denotes	vertebrate
T4789	1498-1502	SO_EXT:0000704	denotes	gene
T4790	1539-1549	GO_SO_EXT:chromosome	denotes	chromosome
T4791	1539-1558	GO:0007129	denotes	chromosome synapsis

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PMC:1941754 / 25362-29905 JSON TXT