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Id Subject Object Predicate Lexical cue
T140 0-103 sentence denotes Mouse Pachytene Checkpoint 2 (Trip13) Is Required for Completing Meiotic Recombination but Not Synapsis
T141 6-15 NN denotes Pachytene
T142 41-49 VBN denotes Required
T143 27-28 CD denotes 2
T144 29-30 -LRB- denotes (
T145 30-36 NN denotes Trip13
T146 36-37 -RRB- denotes )
T147 38-40 VBZ denotes Is
T148 50-53 IN denotes for
T149 54-64 VBG denotes Completing
T150 65-72 JJ denotes Meiotic
T151 73-86 NN denotes Recombination
T152 87-90 CC denotes but
T153 91-94 RB denotes Not
T154 95-103 NN denotes Synapsis
T155 103-232 sentence denotes (Trip13) and Meiotic Recombination Abstract In mammalian meiosis, homologous chromosome synapsis is coupled with recombination.
T156 149-151 IN denotes In
T157 205-212 VBN denotes coupled
T158 152-161 JJ denotes mammalian
T159 162-169 NN denotes meiosis
T160 169-171 , denotes ,
T161 171-181 JJ denotes homologous
T162 193-201 NN denotes synapsis
T163 182-192 NN denotes chromosome
T164 202-204 VBZ denotes is
T165 213-217 IN denotes with
T166 218-231 NN denotes recombination
T167 231-232 . denotes .
T168 232-338 sentence denotes As in most eukaryotes, mammalian meiocytes have checkpoints that monitor the fidelity of these processes.
T169 233-235 IN denotes As
T170 276-280 VBP denotes have
T171 236-238 IN denotes in
T172 239-243 JJS denotes most
T173 244-254 NNS denotes eukaryotes
T174 254-256 , denotes ,
T175 256-265 JJ denotes mammalian
T176 266-275 NNS denotes meiocytes
T177 281-292 NNS denotes checkpoints
T178 293-297 WDT denotes that
T179 298-305 VBP denotes monitor
T180 306-309 DT denotes the
T181 310-318 NN denotes fidelity
T182 319-321 IN denotes of
T183 322-327 DT denotes these
T184 328-337 NNS denotes processes
T185 337-338 . denotes .
T186 338-574 sentence denotes We report that the mouse ortholog (Trip13) of pachytene checkpoint 2 (PCH2), an essential component of the synapsis checkpoint in Saccharomyces cerevisiae and Caenorhabditis elegans, is required for completion of meiosis in both sexes.
T187 339-341 PRP denotes We
T188 342-348 VBP denotes report
T189 349-353 IN denotes that
T190 525-533 VBN denotes required
T191 354-357 DT denotes the
T192 364-372 NN denotes ortholog
T193 358-363 NN denotes mouse
T194 373-374 -LRB- denotes (
T195 374-380 NN denotes Trip13
T196 380-381 -RRB- denotes )
T197 382-384 IN denotes of
T198 385-394 NN denotes pachytene
T199 395-405 NN denotes checkpoint
T200 406-407 CD denotes 2
T201 408-409 -LRB- denotes (
T202 409-413 NN denotes PCH2
T203 413-414 -RRB- denotes )
T204 414-416 , denotes ,
T205 416-418 DT denotes an
T206 429-438 NN denotes component
T207 419-428 JJ denotes essential
T208 439-441 IN denotes of
T209 442-445 DT denotes the
T210 455-465 NN denotes checkpoint
T211 446-454 NN denotes synapsis
T212 466-468 IN denotes in
T213 469-482 NNP denotes Saccharomyces
T214 483-493 NNP denotes cerevisiae
T215 494-497 CC denotes and
T216 498-512 NNP denotes Caenorhabditis
T217 513-520 NNP denotes elegans
T218 520-522 , denotes ,
T219 522-524 VBZ denotes is
T220 534-537 IN denotes for
T221 538-548 NN denotes completion
T222 549-551 IN denotes of
T223 552-559 NN denotes meiosis
T224 560-562 IN denotes in
T225 563-567 DT denotes both
T226 568-573 NNS denotes sexes
T227 573-574 . denotes .
T228 574-670 sentence denotes TRIP13-deficient mice exhibit spermatocyte death in pachynema and loss of oocytes around birth.
T229 575-581 NN denotes TRIP13
T230 582-591 JJ denotes deficient
T231 581-582 HYPH denotes -
T232 592-596 NNS denotes mice
T233 597-604 VBP denotes exhibit
T234 605-617 NN denotes spermatocyte
T235 618-623 NN denotes death
T236 624-626 IN denotes in
T237 627-636 NN denotes pachynema
T238 637-640 CC denotes and
T239 641-645 NN denotes loss
T240 646-648 IN denotes of
T241 649-656 NNS denotes oocytes
T242 657-663 IN denotes around
T243 664-669 NN denotes birth
T244 669-670 . denotes .
T245 670-815 sentence denotes The chromosomes of mutant spermatocytes synapse fully, yet retain several markers of recombination intermediates, including RAD51, BLM, and RPA.
T246 671-674 DT denotes The
T247 675-686 NNS denotes chromosomes
T248 711-718 VBP denotes synapse
T249 687-689 IN denotes of
T250 690-696 NN denotes mutant
T251 697-710 NNS denotes spermatocytes
T252 719-724 RB denotes fully
T253 724-726 , denotes ,
T254 726-729 CC denotes yet
T255 730-736 VBP denotes retain
T256 737-744 JJ denotes several
T257 745-752 NNS denotes markers
T258 753-755 IN denotes of
T259 756-769 NN denotes recombination
T260 770-783 NNS denotes intermediates
T261 783-785 , denotes ,
T262 785-794 VBG denotes including
T263 795-800 NN denotes RAD51
T264 800-802 , denotes ,
T265 802-805 NN denotes BLM
T266 805-807 , denotes ,
T267 807-810 CC denotes and
T268 811-814 NN denotes RPA
T269 814-815 . denotes .
T270 815-997 sentence denotes These chromosomes also exhibited the chiasmata markers MLH1 and MLH3, and okadaic acid treatment of mutant spermatocytes caused progression to metaphase I with bivalent chromosomes.
T271 816-821 DT denotes These
T272 822-833 NNS denotes chromosomes
T273 839-848 VBD denotes exhibited
T274 834-838 RB denotes also
T275 849-852 DT denotes the
T276 871-875 NN denotes MLH1
T277 853-862 NNS denotes chiasmata
T278 863-870 NNS denotes markers
T279 876-879 CC denotes and
T280 880-884 NN denotes MLH3
T281 884-886 , denotes ,
T282 886-889 CC denotes and
T283 890-897 JJ denotes okadaic
T284 903-912 NN denotes treatment
T285 898-902 NN denotes acid
T286 937-943 VBD denotes caused
T287 913-915 IN denotes of
T288 916-922 NN denotes mutant
T289 923-936 NNS denotes spermatocytes
T290 944-955 NN denotes progression
T291 956-958 IN denotes to
T292 959-968 NN denotes metaphase
T293 969-970 CD denotes I
T294 971-975 IN denotes with
T295 976-984 JJ denotes bivalent
T296 985-996 NNS denotes chromosomes
T297 996-997 . denotes .
T298 997-1206 sentence denotes Double mutant analysis demonstrated that the recombination and synapsis genes Spo11, Mei1, Rec8, and Dmc1 are all epistatic to Trip13, suggesting that TRIP13 does not have meiotic checkpoint function in mice.
T299 998-1004 JJ denotes Double
T300 1012-1020 NN denotes analysis
T301 1005-1011 NN denotes mutant
T302 1021-1033 VBD denotes demonstrated
T303 1034-1038 IN denotes that
T304 1104-1107 VBP denotes are
T305 1039-1042 DT denotes the
T306 1070-1075 NNS denotes genes
T307 1043-1056 NN denotes recombination
T308 1057-1060 CC denotes and
T309 1061-1069 NN denotes synapsis
T310 1076-1081 NN denotes Spo11
T311 1081-1083 , denotes ,
T312 1083-1087 NN denotes Mei1
T313 1087-1089 , denotes ,
T314 1089-1093 NN denotes Rec8
T315 1093-1095 , denotes ,
T316 1095-1098 CC denotes and
T317 1099-1103 NN denotes Dmc1
T318 1108-1111 RB denotes all
T319 1112-1121 JJ denotes epistatic
T320 1122-1124 IN denotes to
T321 1125-1131 NN denotes Trip13
T322 1131-1133 , denotes ,
T323 1133-1143 VBG denotes suggesting
T324 1144-1148 IN denotes that
T325 1165-1169 VB denotes have
T326 1149-1155 NN denotes TRIP13
T327 1156-1160 VBZ denotes does
T328 1161-1164 RB denotes not
T329 1170-1177 JJ denotes meiotic
T330 1189-1197 NN denotes function
T331 1178-1188 NN denotes checkpoint
T332 1198-1200 IN denotes in
T333 1201-1205 NNS denotes mice
T334 1205-1206 . denotes .
T335 1206-1369 sentence denotes Our data indicate that TRIP13 is required after strand invasion for completing a subset of recombination events, but possibly not those destined to be crossovers.
T336 1207-1210 PRP$ denotes Our
T337 1211-1215 NNS denotes data
T338 1216-1224 VBP denotes indicate
T339 1225-1229 IN denotes that
T340 1240-1248 VBN denotes required
T341 1230-1236 NN denotes TRIP13
T342 1237-1239 VBZ denotes is
T343 1249-1254 IN denotes after
T344 1255-1261 NN denotes strand
T345 1262-1270 NN denotes invasion
T346 1271-1274 IN denotes for
T347 1275-1285 VBG denotes completing
T348 1286-1287 DT denotes a
T349 1288-1294 NN denotes subset
T350 1295-1297 IN denotes of
T351 1298-1311 NN denotes recombination
T352 1312-1318 NNS denotes events
T353 1318-1320 , denotes ,
T354 1320-1323 CC denotes but
T355 1324-1332 RB denotes possibly
T356 1333-1336 RB denotes not
T357 1337-1342 DT denotes those
T358 1343-1351 VBN denotes destined
T359 1352-1354 TO denotes to
T360 1355-1357 VB denotes be
T361 1358-1368 NNS denotes crossovers
T362 1368-1369 . denotes .
T363 1369-1602 sentence denotes To our knowledge, this is the first model to separate recombination defects from asynapsis in mammalian meiosis, and provides the first evidence that unrepaired DNA damage alone can trigger the pachytene checkpoint response in mice.
T364 1370-1372 IN denotes To
T365 1393-1395 VBZ denotes is
T366 1373-1376 PRP$ denotes our
T367 1377-1386 NN denotes knowledge
T368 1386-1388 , denotes ,
T369 1388-1392 DT denotes this
T370 1396-1399 DT denotes the
T371 1406-1411 NN denotes model
T372 1400-1405 JJ denotes first
T373 1412-1414 TO denotes to
T374 1415-1423 VB denotes separate
T375 1424-1437 NN denotes recombination
T376 1438-1445 NNS denotes defects
T377 1446-1450 IN denotes from
T378 1451-1460 NN denotes asynapsis
T379 1461-1463 IN denotes in
T380 1464-1473 JJ denotes mammalian
T381 1474-1481 NN denotes meiosis
T382 1481-1483 , denotes ,
T383 1483-1486 CC denotes and
T384 1487-1495 VBZ denotes provides
T385 1496-1499 DT denotes the
T386 1506-1514 NN denotes evidence
T387 1500-1505 JJ denotes first
T388 1515-1519 IN denotes that
T389 1552-1559 VB denotes trigger
T390 1520-1530 JJ denotes unrepaired
T391 1535-1541 NN denotes damage
T392 1531-1534 NN denotes DNA
T393 1542-1547 RB denotes alone
T394 1548-1551 MD denotes can
T395 1560-1563 DT denotes the
T396 1585-1593 NN denotes response
T397 1564-1573 NN denotes pachytene
T398 1574-1584 NN denotes checkpoint
T399 1594-1596 IN denotes in
T400 1597-1601 NNS denotes mice
T401 1601-1602 . denotes .
T668 2973-2976 DT denotes The
T669 2977-2984 NN denotes genesis
T670 3033-3035 VBZ denotes is
T671 2985-2987 IN denotes of
T672 2988-2995 NNS denotes gametes
T673 2996-3006 VBG denotes containing
T674 3007-3009 DT denotes an
T675 3026-3032 NN denotes genome
T676 3010-3016 JJ denotes intact
T677 3016-3018 , denotes ,
T678 3018-3025 JJ denotes haploid
T679 3036-3044 JJ denotes critical
T680 3045-3048 IN denotes for
T681 3049-3052 DT denotes the
T682 3053-3063 NN denotes prevention
T683 3064-3066 IN denotes of
T684 3067-3072 NN denotes birth
T685 3073-3080 NNS denotes defects
T686 3080-3082 , denotes ,
T687 3082-3085 CC denotes and
T688 3086-3088 VBZ denotes is
T689 3089-3095 RB denotes highly
T690 3096-3105 JJ denotes dependent
T691 3106-3110 IN denotes upon
T692 3111-3114 DT denotes the
T693 3115-3123 NN denotes fidelity
T694 3124-3126 IN denotes of
T695 3127-3137 NN denotes chromosome
T696 3138-3146 NNS denotes dynamics
T697 3147-3153 IN denotes before
T698 3154-3157 DT denotes the
T699 3172-3180 NN denotes division
T700 3158-3163 JJ denotes first
T701 3164-3171 JJ denotes meiotic
T702 3180-3181 . denotes .
T703 3181-3289 sentence denotes Homologous chromosomes must pair, synapse, undergo recombination, and segregate properly to opposite poles.
T704 3182-3192 JJ denotes Homologous
T705 3193-3204 NNS denotes chromosomes
T706 3210-3214 VB denotes pair
T707 3205-3209 MD denotes must
T708 3214-3216 , denotes ,
T709 3216-3223 VB denotes synapse
T710 3223-3225 , denotes ,
T711 3225-3232 VB denotes undergo
T712 3233-3246 NN denotes recombination
T713 3246-3248 , denotes ,
T714 3248-3251 CC denotes and
T715 3252-3261 VB denotes segregate
T716 3262-3270 RB denotes properly
T717 3271-3273 IN denotes to
T718 3274-3282 JJ denotes opposite
T719 3283-3288 NNS denotes poles
T720 3288-3289 . denotes .
T721 3289-3451 sentence denotes Recombination, which repairs repair double strand breaks (DSBs) that are genetically induced in leptonema, is coupled with synapsis in budding yeast and mammals.
T722 3290-3303 NN denotes Recombination
T723 3400-3407 VBN denotes coupled
T724 3303-3305 , denotes ,
T725 3305-3310 WDT denotes which
T726 3311-3318 VBZ denotes repairs
T727 3319-3325 NN denotes repair
T728 3340-3346 NNS denotes breaks
T729 3326-3332 JJ denotes double
T730 3333-3339 NN denotes strand
T731 3347-3348 -LRB- denotes (
T732 3348-3352 NNS denotes DSBs
T733 3352-3353 -RRB- denotes )
T734 3354-3358 WDT denotes that
T735 3375-3382 VBN denotes induced
T736 3359-3362 VBP denotes are
T737 3363-3374 RB denotes genetically
T738 3383-3385 IN denotes in
T739 3386-3395 NN denotes leptonema
T740 3395-3397 , denotes ,
T741 3397-3399 VBZ denotes is
T742 3408-3412 IN denotes with
T743 3413-3421 NN denotes synapsis
T744 3422-3424 IN denotes in
T745 3425-3432 VBG denotes budding
T746 3433-3438 NN denotes yeast
T747 3439-3442 CC denotes and
T748 3443-3450 NNS denotes mammals
T749 3450-3451 . denotes .
T750 3451-3743 sentence denotes While our knowledge of the assembly and nature of recombination machinery is extensive, little is known about the disassembly of recombination intermediates, recruitment of DNA replication machinery during recombinational repair, and how the choice between different repair pathways is made.
T751 3452-3457 IN denotes While
T752 3526-3528 VBZ denotes is
T753 3458-3461 PRP$ denotes our
T754 3462-3471 NN denotes knowledge
T755 3472-3474 IN denotes of
T756 3475-3478 DT denotes the
T757 3479-3487 NN denotes assembly
T758 3488-3491 CC denotes and
T759 3492-3498 NN denotes nature
T760 3499-3501 IN denotes of
T761 3502-3515 NN denotes recombination
T762 3516-3525 NN denotes machinery
T763 3550-3555 VBN denotes known
T764 3529-3538 JJ denotes extensive
T765 3538-3540 , denotes ,
T766 3540-3546 JJ denotes little
T767 3547-3549 VBZ denotes is
T768 3556-3561 IN denotes about
T769 3562-3565 DT denotes the
T770 3566-3577 NN denotes disassembly
T771 3578-3580 IN denotes of
T772 3581-3594 NN denotes recombination
T773 3595-3608 NNS denotes intermediates
T774 3608-3610 , denotes ,
T775 3610-3621 NN denotes recruitment
T776 3622-3624 IN denotes of
T777 3625-3628 NN denotes DNA
T778 3641-3650 NN denotes machinery
T779 3629-3640 NN denotes replication
T780 3651-3657 IN denotes during
T781 3658-3673 JJ denotes recombinational
T782 3674-3680 NN denotes repair
T783 3680-3682 , denotes ,
T784 3682-3685 CC denotes and
T785 3686-3689 WRB denotes how
T786 3738-3742 VBN denotes made
T787 3690-3693 DT denotes the
T788 3694-3700 NN denotes choice
T789 3701-3708 IN denotes between
T790 3709-3718 JJ denotes different
T791 3726-3734 NNS denotes pathways
T792 3719-3725 NN denotes repair
T793 3735-3737 VBZ denotes is
T794 3742-3743 . denotes .
T795 3743-3898 sentence denotes Defects in recombination can preclude homologous chromosome pairing, leave unrepaired chromosome breaks, and cause aneuploidy by abrogating crossing over.
T796 3744-3751 NNS denotes Defects
T797 3773-3781 VB denotes preclude
T798 3752-3754 IN denotes in
T799 3755-3768 NN denotes recombination
T800 3769-3772 MD denotes can
T801 3782-3792 JJ denotes homologous
T802 3804-3811 NN denotes pairing
T803 3793-3803 NN denotes chromosome
T804 3811-3813 , denotes ,
T805 3813-3818 VBP denotes leave
T806 3819-3829 JJ denotes unrepaired
T807 3841-3847 NNS denotes breaks
T808 3830-3840 NN denotes chromosome
T809 3847-3849 , denotes ,
T810 3849-3852 CC denotes and
T811 3853-3858 VBP denotes cause
T812 3859-3869 NN denotes aneuploidy
T813 3870-3872 IN denotes by
T814 3873-3883 VBG denotes abrogating
T815 3884-3892 VBG denotes crossing
T816 3893-3897 RP denotes over
T817 3897-3898 . denotes .
T818 3898-4052 sentence denotes To avoid such deleterious outcomes, surveillance systems (“checkpoints”) exist to sense meiotic errors and eliminate cells containing unresolved defects.
T819 3899-3901 TO denotes To
T820 3902-3907 VB denotes avoid
T821 3972-3977 VBP denotes exist
T822 3908-3912 JJ denotes such
T823 3925-3933 NNS denotes outcomes
T824 3913-3924 JJ denotes deleterious
T825 3933-3935 , denotes ,
T826 3935-3947 NN denotes surveillance
T827 3948-3955 NNS denotes systems
T828 3956-3957 -LRB- denotes (
T829 3957-3958 `` denotes “
T830 3958-3969 NNS denotes checkpoints
T831 3969-3970 '' denotes ”
T832 3970-3971 -RRB- denotes )
T833 3978-3980 TO denotes to
T834 3981-3986 VB denotes sense
T835 3987-3994 JJ denotes meiotic
T836 3995-4001 NNS denotes errors
T837 4002-4005 CC denotes and
T838 4006-4015 VB denotes eliminate
T839 4016-4021 NNS denotes cells
T840 4022-4032 VBG denotes containing
T841 4033-4043 JJ denotes unresolved
T842 4044-4051 NNS denotes defects
T843 4051-4052 . denotes .
T844 4052-4285 sentence denotes In many organisms, including S. cerevisiae, Drosophila melanogaster, C. elegans, and mice [1–4], meiocytes with defects in recombination and/or chromosome synapsis trigger meiotic arrest in the pachytene stage of meiotic prophase I.
T845 4053-4055 IN denotes In
T846 4217-4224 VBP denotes trigger
T847 4056-4060 JJ denotes many
T848 4061-4070 NNS denotes organisms
T849 4070-4072 , denotes ,
T850 4072-4081 VBG denotes including
T851 4082-4084 NNP denotes S.
T852 4085-4095 NNP denotes cerevisiae
T853 4095-4097 , denotes ,
T854 4097-4107 NNP denotes Drosophila
T855 4108-4120 NNP denotes melanogaster
T856 4120-4122 , denotes ,
T857 4122-4124 NNP denotes C.
T858 4125-4132 NNP denotes elegans
T859 4132-4134 , denotes ,
T860 4134-4137 CC denotes and
T861 4138-4142 NNS denotes mice
T862 4143-4144 -LRB- denotes [
T863 4144-4145 CD denotes 1
T864 4145-4146 SYM denotes –
T865 4146-4147 CD denotes 4
T866 4147-4148 -RRB- denotes ]
T867 4148-4150 , denotes ,
T868 4150-4159 NNS denotes meiocytes
T869 4160-4164 IN denotes with
T870 4165-4172 NNS denotes defects
T871 4173-4175 IN denotes in
T872 4176-4189 NN denotes recombination
T873 4190-4193 CC denotes and
T874 4193-4194 HYPH denotes /
T875 4194-4196 CC denotes or
T876 4197-4207 NN denotes chromosome
T877 4208-4216 NN denotes synapsis
T878 4225-4232 JJ denotes meiotic
T879 4233-4239 NN denotes arrest
T880 4240-4242 IN denotes in
T881 4243-4246 DT denotes the
T882 4257-4262 NN denotes stage
T883 4247-4256 NN denotes pachytene
T884 4263-4265 IN denotes of
T885 4266-4273 JJ denotes meiotic
T886 4274-4282 NN denotes prophase
T887 4283-4284 CD denotes I
T888 4284-4285 . denotes .
T889 4285-4382 sentence denotes This response to meiotic defects is referred to as the “pachytene checkpoint” (reviewed in [5]).
T890 4286-4290 DT denotes This
T891 4291-4299 NN denotes response
T892 4322-4330 VBN denotes referred
T893 4300-4302 IN denotes to
T894 4303-4310 JJ denotes meiotic
T895 4311-4318 NNS denotes defects
T896 4319-4321 VBZ denotes is
T897 4331-4333 IN denotes to
T898 4334-4336 IN denotes as
T899 4337-4340 DT denotes the
T900 4352-4362 NN denotes checkpoint
T901 4341-4342 `` denotes “
T902 4342-4351 NN denotes pachytene
T903 4362-4363 NN denotes ”
T904 4364-4365 -LRB- denotes (
T905 4365-4373 VBN denotes reviewed
T906 4374-4376 IN denotes in
T907 4377-4378 -LRB- denotes [
T908 4378-4379 CD denotes 5
T909 4379-4380 -RRB- denotes ]
T910 4380-4381 -RRB- denotes )
T911 4381-4382 . denotes .
T912 4382-4501 sentence denotes Genetic experiments in S. cerevisiae have identified elements of the pachytene checkpoint machinery (reviewed in [5]).
T913 4383-4390 JJ denotes Genetic
T914 4391-4402 NNS denotes experiments
T915 4425-4435 VBN denotes identified
T916 4403-4405 IN denotes in
T917 4406-4408 NNP denotes S.
T918 4409-4419 NNP denotes cerevisiae
T919 4420-4424 VBP denotes have
T920 4436-4444 NNS denotes elements
T921 4445-4447 IN denotes of
T922 4448-4451 DT denotes the
T923 4473-4482 NN denotes machinery
T924 4452-4461 NN denotes pachytene
T925 4462-4472 NN denotes checkpoint
T926 4483-4484 -LRB- denotes (
T927 4484-4492 VBN denotes reviewed
T928 4493-4495 IN denotes in
T929 4496-4497 -LRB- denotes [
T930 4497-4498 CD denotes 5
T931 4498-4499 -RRB- denotes ]
T932 4499-4500 -RRB- denotes )
T933 4500-4501 . denotes .
T934 4501-4630 sentence denotes In addition to meiosis-specific proteins, these include factors that play roles in DNA damage signaling in mitotic cells [6–10].
T935 4502-4504 IN denotes In
T936 4550-4557 VBP denotes include
T937 4505-4513 NN denotes addition
T938 4514-4516 IN denotes to
T939 4517-4524 NN denotes meiosis
T940 4525-4533 JJ denotes specific
T941 4524-4525 HYPH denotes -
T942 4534-4542 NN denotes proteins
T943 4542-4544 , denotes ,
T944 4544-4549 DT denotes these
T945 4558-4565 NNS denotes factors
T946 4566-4570 WDT denotes that
T947 4571-4575 VBP denotes play
T948 4576-4581 NNS denotes roles
T949 4582-4584 IN denotes in
T950 4585-4588 NN denotes DNA
T951 4589-4595 NN denotes damage
T952 4596-4605 NN denotes signaling
T953 4606-4608 IN denotes in
T954 4609-4616 JJ denotes mitotic
T955 4617-4622 NNS denotes cells
T956 4623-4624 -LRB- denotes [
T957 4624-4625 CD denotes 6
T958 4625-4626 SYM denotes –
T959 4626-4628 CD denotes 10
T960 4628-4629 -RRB- denotes ]
T961 4629-4630 . denotes .
T962 4630-4750 sentence denotes Arabidopsis thaliana does not appear to have a pachytene checkpoint akin to that in yeast [11], nor do male Drosophila.
T963 4631-4642 NNP denotes Arabidopsis
T964 4643-4651 NNP denotes thaliana
T965 4661-4667 VB denotes appear
T966 4652-4656 VBZ denotes does
T967 4657-4660 RB denotes not
T968 4668-4670 TO denotes to
T969 4671-4675 VB denotes have
T970 4676-4677 DT denotes a
T971 4688-4698 NN denotes checkpoint
T972 4678-4687 NN denotes pachytene
T973 4699-4703 JJ denotes akin
T974 4704-4706 IN denotes to
T975 4707-4711 DT denotes that
T976 4712-4714 IN denotes in
T977 4715-4720 NN denotes yeast
T978 4721-4722 -LRB- denotes [
T979 4722-4724 CD denotes 11
T980 4724-4725 -RRB- denotes ]
T981 4725-4727 , denotes ,
T982 4727-4730 CC denotes nor
T983 4731-4733 VB denotes do
T984 4734-4738 JJ denotes male
T985 4739-4749 NNP denotes Drosophila
T986 4749-4750 . denotes .
T987 4750-4924 sentence denotes The pachytene checkpoint is known to monitor two aspects of meiotic chromosome metabolism in S. cerevisiae and C. elegans: (1) DSB repair and (2) chromosome synapsis [2,12].
T988 4751-4754 DT denotes The
T989 4765-4775 NN denotes checkpoint
T990 4755-4764 NN denotes pachytene
T991 4779-4784 VBN denotes known
T992 4776-4778 VBZ denotes is
T993 4785-4787 TO denotes to
T994 4788-4795 VB denotes monitor
T995 4796-4799 CD denotes two
T996 4800-4807 NNS denotes aspects
T997 4808-4810 IN denotes of
T998 4811-4818 JJ denotes meiotic
T999 4830-4840 NN denotes metabolism
T1000 4819-4829 NN denotes chromosome
T1001 4841-4843 IN denotes in
T1002 4844-4846 NNP denotes S.
T1003 4847-4857 NNP denotes cerevisiae
T1004 4858-4861 CC denotes and
T1005 4862-4864 NNP denotes C.
T1006 4865-4872 NNP denotes elegans
T1007 4872-4874 : denotes :
T1008 4874-4875 -LRB- denotes (
T1009 4875-4876 LS denotes 1
T1010 4882-4888 NN denotes repair
T1011 4876-4877 -RRB- denotes )
T1012 4878-4881 NN denotes DSB
T1013 4889-4892 CC denotes and
T1014 4893-4894 -LRB- denotes (
T1015 4894-4895 LS denotes 2
T1016 4908-4916 NN denotes synapsis
T1017 4895-4896 -RRB- denotes )
T1018 4897-4907 NN denotes chromosome
T1019 4917-4918 -LRB- denotes [
T1020 4920-4922 CD denotes 12
T1021 4918-4919 CD denotes 2
T1022 4919-4920 , denotes ,
T1023 4922-4923 -RRB- denotes ]
T1024 4923-4924 . denotes .
T1025 4924-5186 sentence denotes In mice, both spermatocytes and oocytes harboring mutations that disrupt DSB repair (such as Dmc1, Msh5, and Atm) are efficiently eliminated in pachynema, but spermatocytes are much more sensitive to DSB repair–independent synapsis defects than oocytes [13–15].
T1026 4925-4927 IN denotes In
T1027 5055-5065 VBN denotes eliminated
T1028 4928-4932 NNS denotes mice
T1029 4932-4934 , denotes ,
T1030 4934-4938 CC denotes both
T1031 4939-4952 NNS denotes spermatocytes
T1032 4953-4956 CC denotes and
T1033 4957-4964 NNS denotes oocytes
T1034 4965-4974 VBG denotes harboring
T1035 4975-4984 NNS denotes mutations
T1036 4985-4989 WDT denotes that
T1037 4990-4997 VBP denotes disrupt
T1038 4998-5001 NN denotes DSB
T1039 5002-5008 NN denotes repair
T1040 5009-5010 -LRB- denotes (
T1041 5010-5014 JJ denotes such
T1042 5015-5017 IN denotes as
T1043 5018-5022 NN denotes Dmc1
T1044 5022-5024 , denotes ,
T1045 5024-5028 NN denotes Msh5
T1046 5028-5030 , denotes ,
T1047 5030-5033 CC denotes and
T1048 5034-5037 NN denotes Atm
T1049 5037-5038 -RRB- denotes )
T1050 5039-5042 VBP denotes are
T1051 5043-5054 RB denotes efficiently
T1052 5066-5068 IN denotes in
T1053 5069-5078 NN denotes pachynema
T1054 5078-5080 , denotes ,
T1055 5080-5083 CC denotes but
T1056 5084-5097 NNS denotes spermatocytes
T1057 5098-5101 VBP denotes are
T1058 5102-5106 RB denotes much
T1059 5107-5111 RBR denotes more
T1060 5112-5121 JJ denotes sensitive
T1061 5122-5124 IN denotes to
T1062 5125-5128 NN denotes DSB
T1063 5157-5164 NNS denotes defects
T1064 5129-5135 NN denotes repair
T1065 5136-5147 JJ denotes independent
T1066 5135-5136 HYPH denotes –
T1067 5148-5156 NN denotes synapsis
T1068 5165-5169 IN denotes than
T1069 5170-5177 NNS denotes oocytes
T1070 5178-5179 -LRB- denotes [
T1071 5179-5181 CD denotes 13
T1072 5181-5182 SYM denotes –
T1073 5182-5184 CD denotes 15
T1074 5184-5185 -RRB- denotes ]
T1075 5185-5186 . denotes .
T1076 5186-5537 sentence denotes However, because recombination is required for synapsis in mice (mutations in recombination genes such as Dmc1 cause extensive asynapsis [16]), it has remained formally uncertain whether there is a distinct pachytene checkpoint that responds to defects in meiotic recombination, and if so, whether it would be identical to that used in somatic cells.
T1077 5187-5194 RB denotes However
T1078 5338-5346 VBN denotes remained
T1079 5194-5196 , denotes ,
T1080 5196-5203 IN denotes because
T1081 5221-5229 VBN denotes required
T1082 5204-5217 NN denotes recombination
T1083 5218-5220 VBZ denotes is
T1084 5230-5233 IN denotes for
T1085 5234-5242 NN denotes synapsis
T1086 5243-5245 IN denotes in
T1087 5246-5250 NNS denotes mice
T1088 5251-5252 -LRB- denotes (
T1089 5298-5303 VBP denotes cause
T1090 5252-5261 NNS denotes mutations
T1091 5262-5264 IN denotes in
T1092 5265-5278 NN denotes recombination
T1093 5279-5284 NNS denotes genes
T1094 5285-5289 JJ denotes such
T1095 5290-5292 IN denotes as
T1096 5293-5297 NN denotes Dmc1
T1097 5304-5313 JJ denotes extensive
T1098 5314-5323 NN denotes asynapsis
T1099 5324-5325 -LRB- denotes [
T1100 5325-5327 CD denotes 16
T1101 5327-5328 -RRB- denotes ]
T1102 5328-5329 -RRB- denotes )
T1103 5329-5331 , denotes ,
T1104 5331-5333 PRP denotes it
T1105 5334-5337 VBZ denotes has
T1106 5347-5355 RB denotes formally
T1107 5356-5365 JJ denotes uncertain
T1108 5366-5373 IN denotes whether
T1109 5380-5382 VBZ denotes is
T1110 5374-5379 EX denotes there
T1111 5383-5384 DT denotes a
T1112 5404-5414 NN denotes checkpoint
T1113 5385-5393 JJ denotes distinct
T1114 5394-5403 NN denotes pachytene
T1115 5415-5419 WDT denotes that
T1116 5420-5428 VBZ denotes responds
T1117 5429-5431 IN denotes to
T1118 5432-5439 NNS denotes defects
T1119 5440-5442 IN denotes in
T1120 5443-5450 JJ denotes meiotic
T1121 5451-5464 NN denotes recombination
T1122 5464-5466 , denotes ,
T1123 5466-5469 CC denotes and
T1124 5470-5472 IN denotes if
T1125 5473-5475 RB denotes so
T1126 5494-5496 VB denotes be
T1127 5475-5477 , denotes ,
T1128 5477-5484 IN denotes whether
T1129 5485-5487 PRP denotes it
T1130 5488-5493 MD denotes would
T1131 5497-5506 JJ denotes identical
T1132 5507-5509 IN denotes to
T1133 5510-5514 DT denotes that
T1134 5515-5519 VBN denotes used
T1135 5520-5522 IN denotes in
T1136 5523-5530 JJ denotes somatic
T1137 5531-5536 NNS denotes cells
T1138 5536-5537 . denotes .
T1139 5537-5677 sentence denotes The mechanisms of putative pachytene checkpoint control remain unknown in mammals, since no mutations have been identified that abolish it.
T1140 5538-5541 DT denotes The
T1141 5542-5552 NNS denotes mechanisms
T1142 5594-5600 VBP denotes remain
T1143 5553-5555 IN denotes of
T1144 5556-5564 JJ denotes putative
T1145 5586-5593 NN denotes control
T1146 5565-5574 NN denotes pachytene
T1147 5575-5585 NN denotes checkpoint
T1148 5601-5608 JJ denotes unknown
T1149 5609-5611 IN denotes in
T1150 5612-5619 NNS denotes mammals
T1151 5619-5621 , denotes ,
T1152 5621-5626 IN denotes since
T1153 5650-5660 VBN denotes identified
T1154 5627-5629 DT denotes no
T1155 5630-5639 NNS denotes mutations
T1156 5640-5644 VBP denotes have
T1157 5645-5649 VBN denotes been
T1158 5661-5665 WDT denotes that
T1159 5666-5673 VBP denotes abolish
T1160 5674-5676 PRP denotes it
T1161 5676-5677 . denotes .
T1162 5677-6002 sentence denotes PCH2, encoding a nucleolar-localized AAA-ATPase that was originally identified in an S. cerevisiae genetic screen for mutants that relieve pachytene arrest of asynaptic zip1 mutants [8], was recently determined to be an essential component of the pachytene synapsis (but not DSB repair) checkpoint in yeast and worms [2,12].
T1163 5678-5682 NN denotes PCH2
T1164 5878-5888 VBN denotes determined
T1165 5682-5684 , denotes ,
T1166 5684-5692 VBG denotes encoding
T1167 5693-5694 DT denotes a
T1168 5719-5725 NN denotes ATPase
T1169 5695-5704 JJ denotes nucleolar
T1170 5705-5714 VBN denotes localized
T1171 5704-5705 HYPH denotes -
T1172 5715-5718 NN denotes AAA
T1173 5718-5719 HYPH denotes -
T1174 5726-5730 WDT denotes that
T1175 5746-5756 VBN denotes identified
T1176 5731-5734 VBD denotes was
T1177 5735-5745 RB denotes originally
T1178 5757-5759 IN denotes in
T1179 5760-5762 DT denotes an
T1180 5785-5791 NN denotes screen
T1181 5763-5765 NNP denotes S.
T1182 5766-5776 NNP denotes cerevisiae
T1183 5777-5784 JJ denotes genetic
T1184 5792-5795 IN denotes for
T1185 5796-5803 NNS denotes mutants
T1186 5804-5808 WDT denotes that
T1187 5809-5816 VBP denotes relieve
T1188 5817-5826 NN denotes pachytene
T1189 5827-5833 NN denotes arrest
T1190 5834-5836 IN denotes of
T1191 5837-5846 JJ denotes asynaptic
T1192 5852-5859 NNS denotes mutants
T1193 5847-5851 NN denotes zip1
T1194 5860-5861 -LRB- denotes [
T1195 5861-5862 CD denotes 8
T1196 5862-5863 -RRB- denotes ]
T1197 5863-5865 , denotes ,
T1198 5865-5868 VBD denotes was
T1199 5869-5877 RB denotes recently
T1200 5889-5891 TO denotes to
T1201 5892-5894 VB denotes be
T1202 5895-5897 DT denotes an
T1203 5908-5917 NN denotes component
T1204 5898-5907 JJ denotes essential
T1205 5918-5920 IN denotes of
T1206 5921-5924 DT denotes the
T1207 5965-5975 NN denotes checkpoint
T1208 5925-5934 NN denotes pachytene
T1209 5935-5943 NN denotes synapsis
T1210 5944-5945 -LRB- denotes (
T1211 5945-5948 CC denotes but
T1212 5949-5952 RB denotes not
T1213 5953-5956 NN denotes DSB
T1214 5957-5963 NN denotes repair
T1215 5963-5964 -RRB- denotes )
T1216 5976-5978 IN denotes in
T1217 5979-5984 NN denotes yeast
T1218 5985-5988 CC denotes and
T1219 5989-5994 NNS denotes worms
T1220 5995-5996 -LRB- denotes [
T1221 5998-6000 CD denotes 12
T1222 5996-5997 CD denotes 2
T1223 5997-5998 , denotes ,
T1224 6000-6001 -RRB- denotes ]
T1225 6001-6002 . denotes .
T1226 6002-6238 sentence denotes PCH2 orthologs are present in organisms that undergo synaptic meiosis, but not asynaptic meiosis, prompting the suggestion that a Pch2-dependent checkpoint evolved to monitor synaptonemal complex (SC) defects from yeast to humans [12].
T1227 6003-6007 NN denotes PCH2
T1228 6008-6017 NNS denotes orthologs
T1229 6018-6021 VBP denotes are
T1230 6022-6029 JJ denotes present
T1231 6030-6032 IN denotes in
T1232 6033-6042 NNS denotes organisms
T1233 6043-6047 WDT denotes that
T1234 6048-6055 VBP denotes undergo
T1235 6056-6064 JJ denotes synaptic
T1236 6065-6072 NN denotes meiosis
T1237 6072-6074 , denotes ,
T1238 6074-6077 CC denotes but
T1239 6078-6081 RB denotes not
T1240 6082-6091 JJ denotes asynaptic
T1241 6092-6099 NN denotes meiosis
T1242 6099-6101 , denotes ,
T1243 6101-6110 VBG denotes prompting
T1244 6111-6114 DT denotes the
T1245 6115-6125 NN denotes suggestion
T1246 6126-6130 IN denotes that
T1247 6159-6166 VBD denotes evolved
T1248 6131-6132 DT denotes a
T1249 6148-6158 NN denotes checkpoint
T1250 6133-6137 NN denotes Pch2
T1251 6138-6147 JJ denotes dependent
T1252 6137-6138 HYPH denotes -
T1253 6167-6169 TO denotes to
T1254 6170-6177 VB denotes monitor
T1255 6178-6190 JJ denotes synaptonemal
T1256 6191-6198 NN denotes complex
T1257 6204-6211 NNS denotes defects
T1258 6199-6200 -LRB- denotes (
T1259 6200-6202 NN denotes SC
T1260 6202-6203 -RRB- denotes )
T1261 6212-6216 IN denotes from
T1262 6217-6222 NN denotes yeast
T1263 6223-6225 IN denotes to
T1264 6226-6232 NNS denotes humans
T1265 6233-6234 -LRB- denotes [
T1266 6234-6236 CD denotes 12
T1267 6236-6237 -RRB- denotes ]
T1268 6237-6238 . denotes .
T1269 6238-6382 sentence denotes Here, we generated mice deficient for the Trip13, the ortholog of PCH2, and evaluated whether it also plays a role in the pachytene checkpoint.
T1270 6239-6243 RB denotes Here
T1271 6248-6257 VBD denotes generated
T1272 6243-6245 , denotes ,
T1273 6245-6247 PRP denotes we
T1274 6258-6262 NNS denotes mice
T1275 6263-6272 JJ denotes deficient
T1276 6273-6276 IN denotes for
T1277 6277-6280 DT denotes the
T1278 6281-6287 NN denotes Trip13
T1279 6287-6289 , denotes ,
T1280 6289-6292 DT denotes the
T1281 6293-6301 NN denotes ortholog
T1282 6302-6304 IN denotes of
T1283 6305-6309 NN denotes PCH2
T1284 6309-6311 , denotes ,
T1285 6311-6314 CC denotes and
T1286 6315-6324 VBD denotes evaluated
T1287 6325-6332 IN denotes whether
T1288 6341-6346 VBZ denotes plays
T1289 6333-6335 PRP denotes it
T1290 6336-6340 RB denotes also
T1291 6347-6348 DT denotes a
T1292 6349-6353 NN denotes role
T1293 6354-6356 IN denotes in
T1294 6357-6360 DT denotes the
T1295 6371-6381 NN denotes checkpoint
T1296 6361-6370 NN denotes pachytene
T1297 6381-6382 . denotes .
T1298 6382-6543 sentence denotes Surprisingly, while we found no evidence for checkpoint function, we did uncover a potential role for this protein in noncrossover (NCO) repair of meiotic DSBs.
T1299 6383-6395 RB denotes Surprisingly
T1300 6456-6463 VB denotes uncover
T1301 6395-6397 , denotes ,
T1302 6397-6402 IN denotes while
T1303 6406-6411 VBD denotes found
T1304 6403-6405 PRP denotes we
T1305 6412-6414 DT denotes no
T1306 6415-6423 NN denotes evidence
T1307 6424-6427 IN denotes for
T1308 6428-6438 NN denotes checkpoint
T1309 6439-6447 NN denotes function
T1310 6447-6449 , denotes ,
T1311 6449-6451 PRP denotes we
T1312 6452-6455 VBD denotes did
T1313 6464-6465 DT denotes a
T1314 6476-6480 NN denotes role
T1315 6466-6475 JJ denotes potential
T1316 6481-6484 IN denotes for
T1317 6485-6489 DT denotes this
T1318 6490-6497 NN denotes protein
T1319 6498-6500 IN denotes in
T1320 6501-6513 JJ denotes noncrossover
T1321 6515-6518 JJ denotes NCO
T1322 6514-6515 -LRB- denotes (
T1323 6520-6526 NN denotes repair
T1324 6518-6519 -RRB- denotes )
T1325 6527-6529 IN denotes of
T1326 6530-6537 JJ denotes meiotic
T1327 6538-6542 NNS denotes DSBs
T1328 6542-6543 . denotes .
T1407 6554-6560 NN denotes Trip13
T1408 6561-6563 VBZ denotes Is
T1409 6564-6565 DT denotes a
T1410 6593-6601 NN denotes Ortholog
T1411 6566-6572 RB denotes Widely
T1412 6573-6582 VBN denotes Expressed
T1413 6583-6592 JJ denotes Mammalian
T1414 6602-6604 IN denotes of
T1415 6605-6609 NN denotes PCH2
T1416 6610-6614 IN denotes with
T1417 6615-6622 JJ denotes Unusual
T1418 6636-6649 NNS denotes Relationships
T1419 6623-6635 JJ denotes Phylogenetic
T1420 6649-6864 sentence denotes The mammalian ortholog of PCH2, Trip13 (thyroid hormone receptor interacting protein 13), encodes a protein with extensive amino acid homology in regions alignable to the yeast and worm orthologs (Figure S1) [12]).
T1421 6650-6653 DT denotes The
T1422 6664-6672 NN denotes ortholog
T1423 6654-6663 JJ denotes mammalian
T1424 6740-6747 VBZ denotes encodes
T1425 6673-6675 IN denotes of
T1426 6676-6680 NN denotes PCH2
T1427 6680-6682 , denotes ,
T1428 6682-6688 NN denotes Trip13
T1429 6689-6690 -LRB- denotes (
T1430 6690-6697 NN denotes thyroid
T1431 6706-6714 NN denotes receptor
T1432 6698-6705 NN denotes hormone
T1433 6715-6726 VBG denotes interacting
T1434 6727-6734 NN denotes protein
T1435 6735-6737 CD denotes 13
T1436 6737-6738 -RRB- denotes )
T1437 6738-6740 , denotes ,
T1438 6748-6749 DT denotes a
T1439 6750-6757 NN denotes protein
T1440 6758-6762 IN denotes with
T1441 6763-6772 JJ denotes extensive
T1442 6784-6792 NN denotes homology
T1443 6773-6778 NN denotes amino
T1444 6779-6783 NN denotes acid
T1445 6793-6795 IN denotes in
T1446 6796-6803 NNS denotes regions
T1447 6804-6813 JJ denotes alignable
T1448 6814-6816 IN denotes to
T1449 6817-6820 DT denotes the
T1450 6836-6845 NNS denotes orthologs
T1451 6821-6826 NN denotes yeast
T1452 6827-6830 CC denotes and
T1453 6831-6835 NN denotes worm
T1454 6846-6847 -LRB- denotes (
T1455 6854-6856 NN denotes S1
T1456 6847-6853 NN denotes Figure
T1457 6856-6857 -RRB- denotes )
T1458 6858-6859 -LRB- denotes [
T1459 6859-6861 CD denotes 12
T1460 6861-6862 -RRB- denotes ]
T1461 6862-6863 -RRB- denotes )
T1462 6863-6864 . denotes .
T1463 6864-7083 sentence denotes Interestingly, phylogenetic analysis of TRIP13/Pch2p shows that the mammalian protein clusters more closely to plants than it does to the evolutionarily more closely related worms and flies (Figure 1A; see Discussion).
T1464 6865-6878 RB denotes Interestingly
T1465 6918-6923 VBZ denotes shows
T1466 6878-6880 , denotes ,
T1467 6880-6892 JJ denotes phylogenetic
T1468 6893-6901 NN denotes analysis
T1469 6902-6904 IN denotes of
T1470 6905-6911 NN denotes TRIP13
T1471 6912-6917 NN denotes Pch2p
T1472 6911-6912 HYPH denotes /
T1473 6924-6928 IN denotes that
T1474 6951-6959 VBZ denotes clusters
T1475 6929-6932 DT denotes the
T1476 6943-6950 NN denotes protein
T1477 6933-6942 JJ denotes mammalian
T1478 6960-6964 RBR denotes more
T1479 6965-6972 RB denotes closely
T1480 6973-6975 IN denotes to
T1481 6976-6982 NNS denotes plants
T1482 6983-6987 IN denotes than
T1483 6996-6998 IN denotes to
T1484 6988-6990 PRP denotes it
T1485 6991-6995 VBZ denotes does
T1486 6999-7002 DT denotes the
T1487 7039-7044 NNS denotes worms
T1488 7003-7017 RB denotes evolutionarily
T1489 7031-7038 VBN denotes related
T1490 7018-7022 RBR denotes more
T1491 7023-7030 RB denotes closely
T1492 7045-7048 CC denotes and
T1493 7049-7054 NNS denotes flies
T1494 7055-7056 -LRB- denotes (
T1495 7063-7065 NN denotes 1A
T1496 7056-7062 NN denotes Figure
T1497 7065-7066 : denotes ;
T1498 7067-7070 VB denotes see
T1499 7071-7081 NN denotes Discussion
T1500 7081-7082 -RRB- denotes )
T1501 7082-7083 . denotes .
T1502 7083-7357 sentence denotes Semi-quantitative reverse-transcriptase PCR (RT-PCR) analysis showed Trip13 mRNA to be expressed in a variety of embryonic and adult tissues, including testis (Figure 1B), consistent with mouse and human EST data summarized in Unigene (http://www.ncbi.nlm.nih.gov/UniGene).
T1503 7084-7101 JJ denotes Semi-quantitative
T1504 7137-7145 NN denotes analysis
T1505 7102-7109 NN denotes reverse
T1506 7110-7123 NN denotes transcriptase
T1507 7109-7110 HYPH denotes -
T1508 7124-7127 NN denotes PCR
T1509 7128-7129 -LRB- denotes (
T1510 7129-7131 NN denotes RT
T1511 7132-7135 NN denotes PCR
T1512 7131-7132 HYPH denotes -
T1513 7135-7136 -RRB- denotes )
T1514 7146-7152 VBD denotes showed
T1515 7153-7159 NN denotes Trip13
T1516 7160-7164 NN denotes mRNA
T1517 7171-7180 VBN denotes expressed
T1518 7165-7167 TO denotes to
T1519 7168-7170 VB denotes be
T1520 7181-7183 IN denotes in
T1521 7184-7185 DT denotes a
T1522 7186-7193 NN denotes variety
T1523 7194-7196 IN denotes of
T1524 7197-7206 JJ denotes embryonic
T1525 7217-7224 NNS denotes tissues
T1526 7207-7210 CC denotes and
T1527 7211-7216 JJ denotes adult
T1528 7224-7226 , denotes ,
T1529 7226-7235 VBG denotes including
T1530 7236-7242 NN denotes testis
T1531 7243-7244 -LRB- denotes (
T1532 7251-7253 NN denotes 1B
T1533 7244-7250 NN denotes Figure
T1534 7253-7254 -RRB- denotes )
T1535 7254-7256 , denotes ,
T1536 7256-7266 JJ denotes consistent
T1537 7267-7271 IN denotes with
T1538 7272-7277 NN denotes mouse
T1539 7288-7291 NN denotes EST
T1540 7278-7281 CC denotes and
T1541 7282-7287 JJ denotes human
T1542 7292-7296 NNS denotes data
T1543 7297-7307 VBN denotes summarized
T1544 7308-7310 IN denotes in
T1545 7311-7318 NNP denotes Unigene
T1546 7319-7320 -LRB- denotes (
T1547 7320-7355 NN denotes http://www.ncbi.nlm.nih.gov/UniGene
T1548 7355-7356 -RRB- denotes )
T1549 7356-7357 . denotes .
T1550 7357-7418 sentence denotes It is also highly expressed in human and mouse oocytes [17].
T1551 7358-7360 PRP denotes It
T1552 7376-7385 VBN denotes expressed
T1553 7361-7363 VBZ denotes is
T1554 7364-7368 RB denotes also
T1555 7369-7375 RB denotes highly
T1556 7386-7388 IN denotes in
T1557 7389-7394 JJ denotes human
T1558 7399-7404 NN denotes mouse
T1559 7395-7398 CC denotes and
T1560 7405-7412 NNS denotes oocytes
T1561 7413-7414 -LRB- denotes [
T1562 7414-7416 CD denotes 17
T1563 7416-7417 -RRB- denotes ]
T1564 7417-7418 . denotes .
T1725 9652-9662 NN denotes Generation
T1726 9663-9665 IN denotes of
T1727 9666-9672 NN denotes Trip13
T1728 9680-9684 NNS denotes Mice
T1729 9673-9679 NN denotes Mutant
T1730 9684-9834 sentence denotes To explore the function of TRIP13 in mammals, we generated mice with a gene trap-disrupted allele, Trip13RRB047 (Figure 1C; abbreviated as Trip13Gt).
T1731 9685-9687 TO denotes To
T1732 9688-9695 VB denotes explore
T1733 9734-9743 VBD denotes generated
T1734 9696-9699 DT denotes the
T1735 9700-9708 NN denotes function
T1736 9709-9711 IN denotes of
T1737 9712-9718 NN denotes TRIP13
T1738 9719-9721 IN denotes in
T1739 9722-9729 NNS denotes mammals
T1740 9729-9731 , denotes ,
T1741 9731-9733 PRP denotes we
T1742 9744-9748 NNS denotes mice
T1743 9749-9753 IN denotes with
T1744 9754-9755 DT denotes a
T1745 9776-9782 NN denotes allele
T1746 9756-9760 NN denotes gene
T1747 9761-9765 NN denotes trap
T1748 9766-9775 VBN denotes disrupted
T1749 9765-9766 HYPH denotes -
T1750 9782-9784 , denotes ,
T1751 9784-9796 NN denotes Trip13RRB047
T1752 9797-9798 -LRB- denotes (
T1753 9805-9807 NN denotes 1C
T1754 9798-9804 NN denotes Figure
T1755 9807-9808 : denotes ;
T1756 9809-9820 VBN denotes abbreviated
T1757 9821-9823 IN denotes as
T1758 9824-9832 NN denotes Trip13Gt
T1759 9832-9833 -RRB- denotes )
T1760 9833-9834 . denotes .
T1761 9834-10026 sentence denotes Heterozygotes were normal in all respects, but homozygotes were present at ∼2/3 the expected ratio from intercrosses between heterozygotes (91 Trip13 +/+, 183 Trip13Gt/+, and 61 Trip13Gt/Gt).
T1762 9835-9848 NNS denotes Heterozygotes
T1763 9849-9853 VBD denotes were
T1764 9854-9860 JJ denotes normal
T1765 9861-9863 IN denotes in
T1766 9864-9867 DT denotes all
T1767 9868-9876 NNS denotes respects
T1768 9876-9878 , denotes ,
T1769 9878-9881 CC denotes but
T1770 9882-9893 NNS denotes homozygotes
T1771 9894-9898 VBD denotes were
T1772 9899-9906 JJ denotes present
T1773 9907-9909 IN denotes at
T1774 9910-9911 SYM denotes ∼
T1775 9913-9914 CD denotes 3
T1776 9911-9912 CD denotes 2
T1777 9912-9913 SYM denotes /
T1778 9928-9933 NN denotes ratio
T1779 9915-9918 DT denotes the
T1780 9919-9927 VBN denotes expected
T1781 9934-9938 IN denotes from
T1782 9939-9951 NNS denotes intercrosses
T1783 9952-9959 IN denotes between
T1784 9960-9973 NNS denotes heterozygotes
T1785 9974-9975 -LRB- denotes (
T1786 9975-9977 CD denotes 91
T1787 9978-9984 NN denotes Trip13
T1788 9985-9986 SYM denotes +
T1789 9986-9987 HYPH denotes /
T1790 9987-9988 SYM denotes +
T1791 9988-9990 , denotes ,
T1792 9990-9993 CD denotes 183
T1793 9994-10002 NN denotes Trip13Gt
T1794 10002-10003 HYPH denotes /
T1795 10003-10004 SYM denotes +
T1796 10004-10006 , denotes ,
T1797 10006-10009 CC denotes and
T1798 10010-10012 CD denotes 61
T1799 10022-10024 NN denotes Gt
T1800 10013-10021 NN denotes Trip13Gt
T1801 10021-10022 HYPH denotes /
T1802 10024-10025 -RRB- denotes )
T1803 10025-10026 . denotes .
T1804 10026-10159 sentence denotes Since >90% of prewean mice that died were mutant homozygotes, this discrepancy is apparently due to a partially penetrant lethality.
T1805 10027-10032 IN denotes Since
T1806 10064-10068 VBD denotes were
T1807 10033-10034 SYM denotes >
T1808 10034-10036 CD denotes 90
T1809 10036-10037 NN denotes %
T1810 10038-10040 IN denotes of
T1811 10041-10048 JJ denotes prewean
T1812 10049-10053 NNS denotes mice
T1813 10054-10058 WDT denotes that
T1814 10059-10063 VBD denotes died
T1815 10106-10108 VBZ denotes is
T1816 10069-10075 NN denotes mutant
T1817 10076-10087 NNS denotes homozygotes
T1818 10087-10089 , denotes ,
T1819 10089-10093 DT denotes this
T1820 10094-10105 NN denotes discrepancy
T1821 10109-10119 RB denotes apparently
T1822 10120-10123 IN denotes due
T1823 10124-10126 IN denotes to
T1824 10127-10128 DT denotes a
T1825 10149-10158 NN denotes lethality
T1826 10129-10138 RB denotes partially
T1827 10139-10148 JJ denotes penetrant
T1828 10158-10159 . denotes .
T1829 10159-10215 sentence denotes Most surviving Trip13Gt/Gt animals were grossly normal.
T1830 10160-10164 JJS denotes Most
T1831 10187-10194 NNS denotes animals
T1832 10165-10174 VBG denotes surviving
T1833 10175-10183 NN denotes Trip13Gt
T1834 10184-10186 NN denotes Gt
T1835 10183-10184 HYPH denotes /
T1836 10195-10199 VBD denotes were
T1837 10200-10207 RB denotes grossly
T1838 10208-10214 JJ denotes normal
T1839 10214-10215 . denotes .
T1840 10215-10371 sentence denotes However, homozygotes that were semi-congenic (N4) on the C57BL/6J strain were often markedly smaller and/or had kinked or shorter tails (Figure 2A and 2B).
T1841 10216-10223 RB denotes However
T1842 10289-10293 VBD denotes were
T1843 10223-10225 , denotes ,
T1844 10225-10236 NNS denotes homozygotes
T1845 10237-10241 WDT denotes that
T1846 10242-10246 VBD denotes were
T1878 11176-11179 NN denotes PCR
T1879 11175-11176 HYPH denotes -
T1880 11180-11188 NN denotes analysis
T1881 11224-11232 VBD denotes revealed
T1882 11189-11191 IN denotes of
T1883 11192-11200 NN denotes Trip13Gt
T1884 11201-11211 NN denotes expression
T1885 11212-11213 -LRB- denotes (
T1886 11220-11222 NN denotes 1D
T1887 11213-11219 NN denotes Figure
T1888 11222-11223 -RRB- denotes )
T1889 11233-11234 DT denotes a
T1890 11239-11244 NN denotes level
T1891 11235-11238 JJ denotes low
T1892 11245-11247 IN denotes of
T1893 11248-11256 RB denotes normally
T1894 11257-11264 VBN denotes spliced
T1895 11265-11276 NNS denotes transcripts
T1896 11277-11279 IN denotes in
T1897 11280-11286 NNS denotes testes
T1898 11287-11289 IN denotes of
T1899 11290-11301 NNS denotes homozygotes
T1900 11302-11306 WDT denotes that
T1901 11307-11309 VBZ denotes is
T1902 11310-11320 RB denotes presumably
T1903 11321-11322 DT denotes a
T1904 11323-11334 NN denotes consequence
T1905 11335-11337 IN denotes of
T1906 11338-11348 JJ denotes incomplete
T1907 11349-11354 NN denotes usage
T1908 11355-11357 IN denotes of
T1909 11358-11361 DT denotes the
T1910 11367-11371 NN denotes trap
T1911 11362-11366 NN denotes gene
T1912 11381-11389 NN denotes acceptor
T1913 11371-11373 POS denotes 's
T1914 11374-11380 NN denotes splice
T1915 11389-11390 . denotes .
T1916 11390-11618 sentence denotes Western blot analysis, using a polyclonal antibody raised against a peptide encoded by exon 3, revealed multiple species in wild-type and heterozygous testes, one of which corresponds to the expected size of 48 kDa (Figure 1E).
T1917 11391-11398 NNP denotes Western
T1918 11399-11403 NN denotes blot
T1919 11404-11412 NN denotes analysis
T1920 11486-11494 VBD denotes revealed
T1921 11412-11414 , denotes ,
T1922 11414-11419 VBG denotes using
T1923 11420-11421 DT denotes a
T1924 11433-11441 NN denotes antibody
T1925 11422-11432 JJ denotes polyclonal
T1926 11442-11448 VBN denotes raised
T1927 11449-11456 IN denotes against
T1928 11457-11458 DT denotes a
T1929 11459-11466 NN denotes peptide
T1930 11467-11474 VBN denotes encoded
T1931 11475-11477 IN denotes by
T1932 11478-11482 NN denotes exon
T1933 11483-11484 CD denotes 3
T1934 11484-11486 , denotes ,
T1935 11495-11503 JJ denotes multiple
T1936 11504-11511 NNS denotes species
T1937 11512-11514 IN denotes in
T1938 11515-11519 JJ denotes wild
T1939 11520-11524 NN denotes type
T1940 11519-11520 HYPH denotes -
T1941 11542-11548 NNS denotes testes
T1942 11525-11528 CC denotes and
T1943 11529-11541 JJ denotes heterozygous
T1944 11548-11550 , denotes ,
T1945 11550-11553 CD denotes one
T1946 11563-11574 VBZ denotes corresponds
T1947 11554-11556 IN denotes of
T1948 11557-11562 WDT denotes which
T1949 11575-11577 IN denotes to
T1950 11578-11581 DT denotes the
T1951 11591-11595 NN denotes size
T1952 11582-11590 VBN denotes expected
T1953 11596-11598 IN denotes of
T1954 11599-11601 CD denotes 48
T1955 11602-11605 NN denotes kDa
T1956 11606-11607 -LRB- denotes (
T1957 11614-11616 NN denotes 1E
T1958 11607-11613 NN denotes Figure
T1959 11616-11617 -RRB- denotes )
T1960 11617-11618 . denotes .
T1961 11618-11763 sentence denotes This and three other species were undetectable in homozygous mutant testes, but a reduced amount of an intense ∼38 kDa smaller band was present.
T1962 11619-11623 DT denotes This
T1963 11648-11652 VBD denotes were
T1964 11624-11627 CC denotes and
T1965 11628-11633 CD denotes three
T1966 11640-11647 NNS denotes species
T1967 11634-11639 JJ denotes other
T1968 11653-11665 JJ denotes undetectable
T1969 11666-11668 IN denotes in
T1970 11669-11679 JJ denotes homozygous
T1971 11680-11686 NN denotes mutant
T1972 11687-11693 NNS denotes testes
T1973 11693-11695 , denotes ,
T1974 11695-11698 CC denotes but
T1975 11699-11700 DT denotes a
T1976 11709-11715 NN denotes amount
T1977 11701-11708 VBN denotes reduced
T1978 11751-11754 VBD denotes was
T1979 11716-11718 IN denotes of
T1980 11719-11721 DT denotes an
T1981 11746-11750 NN denotes band
T1982 11722-11729 JJ denotes intense
T1983 11730-11731 SYM denotes ∼
T1984 11731-11733 CD denotes 38
T1985 11734-11737 NN denotes kDa
T1986 11738-11745 JJR denotes smaller
T1987 11755-11762 JJ denotes present
T1988 11762-11763 . denotes .
T1989 11763-11810 sentence denotes It is not clear if this corresponds to TRIP13.
T1990 11764-11766 PRP denotes It
T1991 11767-11769 VBZ denotes is
T1992 11770-11773 RB denotes not
T1993 11774-11779 JJ denotes clear
T1994 11780-11782 IN denotes if
T1995 11788-11799 VBZ denotes corresponds
T1996 11783-11787 DT denotes this
T1997 11800-11802 IN denotes to
T1998 11803-11809 NN denotes TRIP13
T1999 11809-11810 . denotes .
T2000 11810-11955 sentence denotes The greatly decreased Trip13 mRNA and predicted correct-length protein in mutants indicate that the Trip13RRB047 allele is severely hypomorphic.
T2001 11811-11814 DT denotes The
T2002 11840-11844 NN denotes mRNA
T2003 11815-11822 RB denotes greatly
T2004 11823-11832 VBN denotes decreased
T2005 11833-11839 NN denotes Trip13
T2006 11893-11901 VBP denotes indicate
T2007 11845-11848 CC denotes and
T2008 11849-11858 VBN denotes predicted
T2009 11874-11881 NN denotes protein
T2010 11859-11866 JJ denotes correct
T2011 11867-11873 NN denotes length
T2012 11866-11867 HYPH denotes -
T2013 11882-11884 IN denotes in
T2014 11885-11892 NNS denotes mutants
T2015 11902-11906 IN denotes that
T2016 11931-11933 VBZ denotes is
T2017 11907-11910 DT denotes the
T2018 11924-11930 NN denotes allele
T2019 11911-11923 NN denotes Trip13RRB047
T2020 11934-11942 RB denotes severely
T2021 11943-11954 JJ denotes hypomorphic
T2022 11954-11955 . denotes .
T2023 11955-12227 sentence denotes To determine the germ cell types in which TRIP13 is expressed, and to assess possible expression in the mutant by means other than Western analysis, testis sections were immunolabeled for TRIP13 using a polyclonal chicken antipeptide antibody (see Materials and Methods).
T2024 11956-11958 TO denotes To
T2025 11959-11968 VB denotes determine
T2026 12126-12139 VBN denotes immunolabeled
T2027 11969-11972 DT denotes the
T2028 11983-11988 NNS denotes types
T2029 11973-11977 NN denotes germ
T2030 11978-11982 NN denotes cell
T2031 11989-11991 IN denotes in
T2032 12008-12017 VBN denotes expressed
T2033 11992-11997 WDT denotes which
T2034 11998-12004 NN denotes TRIP13
T2035 12005-12007 VBZ denotes is
T2036 12017-12019 , denotes ,
T2037 12019-12022 CC denotes and
T2038 12023-12025 TO denotes to
T2039 12026-12032 VB denotes assess
T2040 12033-12041 JJ denotes possible
T2041 12042-12052 NN denotes expression
T2042 12053-12055 IN denotes in
T2043 12056-12059 DT denotes the
T2044 12060-12066 NN denotes mutant
T2045 12067-12069 IN denotes by
T2046 12070-12075 NNS denotes means
T2047 12076-12081 JJ denotes other
T2048 12082-12086 IN denotes than
T2049 12087-12094 NNP denotes Western
T2050 12095-12103 NN denotes analysis
T2051 12103-12105 , denotes ,
T2052 12105-12111 NN denotes testis
T2053 12112-12120 NNS denotes sections
T2054 12121-12125 VBD denotes were
T2055 12140-12143 IN denotes for
T2056 12144-12150 NN denotes TRIP13
T2057 12151-12156 VBG denotes using
T2058 12157-12158 DT denotes a
T2059 12190-12198 NN denotes antibody
T2060 12159-12169 JJ denotes polyclonal
T2061 12178-12189 NN denotes antipeptide
T2062 12170-12177 NN denotes chicken
T2063 12199-12200 -LRB- denotes (
T2064 12200-12203 VB denotes see
T2065 12204-12213 NNS denotes Materials
T2066 12214-12217 CC denotes and
T2067 12218-12225 NNS denotes Methods
T2068 12225-12226 -RRB- denotes )
T2069 12226-12227 . denotes .
T2070 12227-12345 sentence denotes The most intensely labeled cells in control testes were Type B spermatogonia and leptotene spermatocytes (Figure 1F).
T2071 12228-12231 DT denotes The
T2072 12255-12260 NNS denotes cells
T2073 12232-12236 RBS denotes most
T2074 12237-12246 RB denotes intensely
T2075 12247-12254 VBN denotes labeled
T2076 12279-12283 VBD denotes were
T2077 12261-12263 IN denotes in
T2078 12264-12271 NN denotes control
T2079 12272-12278 NNS denotes testes
T2080 12284-12288 NN denotes Type
T2081 12289-12290 NN denotes B
T2082 12291-12304 NNS denotes spermatogonia
T2083 12305-12308 CC denotes and
T2084 12309-12318 NN denotes leptotene
T2085 12319-12332 NNS denotes spermatocytes
T2086 12333-12334 -LRB- denotes (
T2087 12341-12343 NN denotes 1F
T2088 12334-12340 NN denotes Figure
T2089 12343-12344 -RRB- denotes )
T2090 12344-12345 . denotes .
T2091 12345-12471 sentence denotes Zygotene/pachytene spermatocytes stained less strongly, and there was no detectable staining in late pachytene spermatocytes.
T2092 12346-12354 NN denotes Zygotene
T2093 12355-12364 NN denotes pachytene
T2094 12354-12355 HYPH denotes /
T2095 12365-12378 NNS denotes spermatocytes
T2096 12379-12386 VBD denotes stained
T2097 12387-12391 RBR denotes less
T2098 12392-12400 RB denotes strongly
T2099 12400-12402 , denotes ,
T2100 12402-12405 CC denotes and
T2101 12406-12411 EX denotes there
T2102 12412-12415 VBD denotes was
T2103 12416-12418 DT denotes no
T2104 12430-12438 NN denotes staining
T2105 12419-12429 JJ denotes detectable
T2106 12439-12441 IN denotes in
T2107 12442-12446 JJ denotes late
T2108 12447-12456 NN denotes pachytene
T2109 12457-12470 NNS denotes spermatocytes
T2110 12470-12471 . denotes .
T2111 12471-12512 sentence denotes TRIP13 appeared to be nuclear localized.
T2112 12472-12478 NN denotes TRIP13
T2113 12479-12487 VBD denotes appeared
T2114 12488-12490 TO denotes to
T2115 12491-12493 VB denotes be
T2116 12494-12501 JJ denotes nuclear
T2117 12502-12511 VBN denotes localized
T2118 12511-12512 . denotes .
T2119 12512-12593 sentence denotes There was no such staining of nuclei in mutant seminiferous tubules (Figure 1F).
T2120 12513-12518 EX denotes There
T2121 12519-12522 VBD denotes was
T2122 12523-12525 DT denotes no
T2123 12531-12539 NN denotes staining
T2124 12526-12530 JJ denotes such
T2125 12540-12542 IN denotes of
T2126 12543-12549 NNS denotes nuclei
T2127 12550-12552 IN denotes in
T2128 12553-12559 NN denotes mutant
T2129 12573-12580 NNS denotes tubules
T2130 12560-12572 JJ denotes seminiferous
T2131 12581-12582 -LRB- denotes (
T2132 12589-12591 NN denotes 1F
T2133 12582-12588 NN denotes Figure
T2134 12591-12592 -RRB- denotes )
T2135 12592-12593 . denotes .
T2136 12593-12736 sentence denotes To further assess the nuclear localization, TRIP13 was used to probe meiotic chromosomes prepared by surface spreading of spermatocyte nuclei.
T2137 12594-12596 TO denotes To
T2138 12605-12611 VB denotes assess
T2139 12597-12604 RB denotes further
T2140 12649-12653 VBN denotes used
T2141 12612-12615 DT denotes the
T2142 12624-12636 NN denotes localization
T2143 12616-12623 JJ denotes nuclear
T2144 12636-12638 , denotes ,
T2145 12638-12644 NN denotes TRIP13
T2146 12645-12648 VBD denotes was
T2147 12654-12656 TO denotes to
T2148 12657-12662 VB denotes probe
T2149 12663-12670 JJ denotes meiotic
T2150 12671-12682 NNS denotes chromosomes
T2151 12683-12691 VBN denotes prepared
T2152 12692-12694 IN denotes by
T2153 12695-12702 NN denotes surface
T2154 12703-12712 NN denotes spreading
T2155 12713-12715 IN denotes of
T2156 12716-12728 NN denotes spermatocyte
T2157 12729-12735 NNS denotes nuclei
T2158 12735-12736 . denotes .
T2159 12736-12912 sentence denotes In wild type, there was diffuse nuclear staining, and no evidence of concentration on SC cores (marked by the axial element protein SYCP3) at any meiotic substage (Figure 1G).
T2160 12737-12739 IN denotes In
T2161 12757-12760 VBD denotes was
T2162 12740-12744 JJ denotes wild
T2163 12745-12749 NN denotes type
T2164 12749-12751 , denotes ,
T2165 12751-12756 EX denotes there
T2166 12761-12768 JJ denotes diffuse
T2167 12777-12785 NN denotes staining
T2168 12769-12776 JJ denotes nuclear
T2169 12785-12787 , denotes ,
T2170 12787-12790 CC denotes and
T2171 12791-12793 DT denotes no
T2172 12794-12802 NN denotes evidence
T2173 12803-12805 IN denotes of
T2174 12806-12819 NN denotes concentration
T2175 12820-12822 IN denotes on
T2176 12823-12825 NN denotes SC
T2177 12826-12831 NNS denotes cores
T2178 12832-12833 -LRB- denotes (
T2179 12833-12839 VBN denotes marked
T2180 12840-12842 IN denotes by
T2181 12843-12846 DT denotes the
T2182 12869-12874 NN denotes SYCP3
T2183 12847-12852 JJ denotes axial
T2184 12853-12860 NN denotes element
T2185 12861-12868 NN denotes protein
T2186 12874-12875 -RRB- denotes )
T2187 12876-12878 IN denotes at
T2188 12879-12882 DT denotes any
T2189 12891-12899 NN denotes substage
T2190 12883-12890 JJ denotes meiotic
T2191 12900-12901 -LRB- denotes (
T2192 12908-12910 NN denotes 1G
T2193 12901-12907 NN denotes Figure
T2194 12910-12911 -RRB- denotes )
T2195 12911-12912 . denotes .
T2196 12912-12974 sentence denotes TRIP13 signal was noticeably absent in mutant meiotic nuclei.
T2197 12913-12919 NN denotes TRIP13
T2198 12920-12926 NN denotes signal
T2199 12927-12930 VBD denotes was
T2200 12931-12941 RB denotes noticeably
T2201 12942-12948 JJ denotes absent
T2202 12949-12951 IN denotes in
T2203 12952-12958 NN denotes mutant
T2204 12967-12973 NNS denotes nuclei
T2205 12959-12966 JJ denotes meiotic
T2206 12973-12974 . denotes .
T2304 12976-12987 NN denotes Infertility
T2305 12988-12991 IN denotes Due
T2306 12992-12994 IN denotes to
T2307 12995-13002 JJ denotes Meiotic
T2308 13003-13013 NN denotes Disruption
T2309 13014-13016 IN denotes in
T2310 13017-13023 NN denotes TRIP13
T2311 13024-13033 JJ denotes Deficient
T2312 13023-13024 HYPH denotes -
T2313 13034-13043 NNS denotes Meiocytes
T2314 13043-13138 sentence denotes Homozygotes of both sexes had small gonads (Figure 2C; see below) and were invariably sterile.
T2315 13044-13055 NNS denotes Homozygotes
T2316 13070-13073 VBD denotes had
T2317 13056-13058 IN denotes of
T2318 13059-13063 DT denotes both
T2319 13064-13069 NNS denotes sexes
T2320 13074-13079 JJ denotes small
T2321 13080-13086 NNS denotes gonads
T2322 13087-13088 -LRB- denotes (
T2323 13095-13097 NN denotes 2C
T2324 13088-13094 NN denotes Figure
T2325 13097-13098 : denotes ;
T2326 13099-13102 VB denotes see
T2327 13103-13108 RB denotes below
T2328 13108-13109 -RRB- denotes )
T2329 13110-13113 CC denotes and
T2330 13114-13118 VBD denotes were
T2331 13119-13129 RB denotes invariably
T2332 13130-13137 JJ denotes sterile
T2333 13137-13138 . denotes .
T2334 13138-13248 sentence denotes Ovaries of adult Trip13Gt/Gt females were severely dysmorphic and had few or no follicles (Figure 3A and 3B).
T2335 13139-13146 NNS denotes Ovaries
T2336 13176-13180 VBD denotes were
T2337 13147-13149 IN denotes of
T2338 13150-13155 JJ denotes adult
T2339 13168-13175 NNS denotes females
T2340 13156-13164 NN denotes Trip13Gt
T2341 13165-13167 NN denotes Gt
T2342 13164-13165 HYPH denotes /
T2343 13181-13189 RB denotes severely
T2344 13190-13200 JJ denotes dysmorphic
T2345 13201-13204 CC denotes and
T2346 13205-13208 VBD denotes had
T2347 13209-13212 JJ denotes few
T2348 13219-13228 NNS denotes follicles
T2349 13213-13215 CC denotes or
T2350 13216-13218 DT denotes no
T2351 13229-13230 -LRB- denotes (
T2352 13237-13239 NN denotes 3A
T2353 13230-13236 NN denotes Figure
T2354 13240-13243 CC denotes and
T2355 13244-13246 NN denotes 3B
T2356 13246-13247 -RRB- denotes )
T2357 13247-13248 . denotes .
T2358 13248-13500 sentence denotes The majority of oocyte loss occurred in late embryogenesis or early in postnatal development, since 2 d postpartum ovaries were markedly smaller than those of control littermates, and were lacking oocytes or newly forming follicles (Figure 3C and 3D).
T2359 13249-13252 DT denotes The
T2360 13253-13261 NN denotes majority
T2361 13277-13285 VBD denotes occurred
T2362 13262-13264 IN denotes of
T2363 13265-13271 NN denotes oocyte
T2364 13272-13276 NN denotes loss
T2365 13286-13288 IN denotes in
T2366 13289-13293 JJ denotes late
T2367 13294-13307 NN denotes embryogenesis
T2368 13308-13310 CC denotes or
T2369 13311-13316 RB denotes early
T2370 13317-13319 IN denotes in
T2371 13320-13329 JJ denotes postnatal
T2372 13330-13341 NN denotes development
T2373 13341-13343 , denotes ,
T2374 13343-13348 IN denotes since
T2375 13372-13376 VBD denotes were
T2376 13349-13350 CD denotes 2
T2377 13351-13352 NN denotes d
T2378 13364-13371 NNS denotes ovaries
T2379 13353-13363 RB denotes postpartum
T2380 13377-13385 RB denotes markedly
T2381 13386-13393 JJR denotes smaller
T2382 13394-13398 IN denotes than
T2383 13399-13404 DT denotes those
T2384 13405-13407 IN denotes of
T2385 13408-13415 NN denotes control
T2386 13416-13427 NNS denotes littermates
T2387 13427-13429 , denotes ,
T2388 13429-13432 CC denotes and
T2389 13433-13437 VBD denotes were
T2390 13438-13445 VBG denotes lacking
T2391 13446-13453 NNS denotes oocytes
T2392 13454-13456 CC denotes or
T2393 13457-13462 RB denotes newly
T2394 13463-13470 VBG denotes forming
T2395 13471-13480 NNS denotes follicles
T2396 13481-13482 -LRB- denotes (
T2397 13489-13491 NN denotes 3C
T2398 13482-13488 NN denotes Figure
T2399 13492-13495 CC denotes and
T2400 13496-13498 NN denotes 3D
T2401 13498-13499 -RRB- denotes )
T2402 13499-13500 . denotes .
T2403 13500-13566 sentence denotes Thus, oocytes failed to progress to the dictyate (resting) phase.
T2404 13501-13505 RB denotes Thus
T2405 13515-13521 VBD denotes failed
T2406 13505-13507 , denotes ,
T2407 13507-13514 NNS denotes oocytes
T2408 13522-13524 TO denotes to
T2409 13525-13533 VB denotes progress
T2410 13534-13536 IN denotes to
T2411 13537-13540 DT denotes the
T2412 13560-13565 NN denotes phase
T2413 13541-13549 NN denotes dictyate
T2414 13550-13551 -LRB- denotes (
T2415 13551-13558 VBG denotes resting
T2416 13558-13559 -RRB- denotes )
T2417 13565-13566 . denotes .
T2418 13566-13771 sentence denotes Since we observed oocytes with pachytene stage chromosomes in 17.5 d Trip13Gt/Gt embryonic ovaries (unpublished data), this indicates that oocytes were eliminated somewhere between pachynema and dictyate.
T2419 13567-13572 IN denotes Since
T2420 13576-13584 VBD denotes observed
T2421 13573-13575 PRP denotes we
T2422 13691-13700 VBZ denotes indicates
T2423 13585-13592 NNS denotes oocytes
T2424 13593-13597 IN denotes with
T2425 13598-13607 NN denotes pachytene
T2426 13608-13613 NN denotes stage
T2427 13614-13625 NNS denotes chromosomes
T2428 13626-13628 IN denotes in
T2429 13629-13633 CD denotes 17.5
T2430 13634-13635 NN denotes d
T2431 13658-13665 NNS denotes ovaries
T2432 13636-13644 NN denotes Trip13Gt
T2433 13645-13647 NN denotes Gt
T2434 13644-13645 HYPH denotes /
T2435 13648-13657 JJ denotes embryonic
T2436 13666-13667 -LRB- denotes (
T2437 13679-13683 NNS denotes data
T2438 13667-13678 JJ denotes unpublished
T2439 13683-13684 -RRB- denotes )
T2440 13684-13686 , denotes ,
T2456 15536-15538 IN denotes of
T2457 15539-15545 NN denotes mutant
T2458 15546-15552 NNS denotes testes
T2459 15562-15563 DT denotes a
T2460 15564-15568 NN denotes lack
T2461 15569-15571 IN denotes of
T2462 15572-15583 JJ denotes postmeiotic
T2463 15589-15594 NNS denotes types
T2464 15584-15588 NN denotes cell
T2465 15595-15599 WDT denotes that
T2466 15600-15603 VBP denotes are
T2467 15604-15618 JJ denotes characteristic
T2468 15619-15621 IN denotes of
T2469 15622-15626 JJ denotes wild
T2470 15627-15631 NN denotes type
T2471 15626-15627 HYPH denotes -
T2472 15645-15652 NNS denotes tubules
T2473 15632-15644 JJ denotes seminiferous
T2474 15653-15654 -LRB- denotes (
T2475 15661-15663 NN denotes 3E
T2476 15654-15660 NN denotes Figure
T2477 15663-15664 -RRB- denotes )
T2478 15664-15665 . denotes .
T2479 15665-15820 sentence denotes The most developmentally advanced seminiferous tubules contained adluminal spermatocytes with condensed chromatin characteristic of pachynema (Figure 3F).
T2480 15666-15669 DT denotes The
T2481 15713-15720 NNS denotes tubules
T2482 15670-15674 RBS denotes most
T2483 15691-15699 VBN denotes advanced
T2484 15675-15690 RB denotes developmentally
T2485 15700-15712 JJ denotes seminiferous
T2486 15721-15730 VBD denotes contained
T2487 15731-15740 JJ denotes adluminal
T2488 15741-15754 NNS denotes spermatocytes
T2489 15755-15759 IN denotes with
T2490 15760-15769 VBN denotes condensed
T2491 15770-15779 NN denotes chromatin
T2492 15780-15794 JJ denotes characteristic
T2493 15795-15797 IN denotes of
T2494 15798-15807 NN denotes pachynema
T2495 15808-15809 -LRB- denotes (
T2496 15816-15818 NN denotes 3F
T2497 15809-15815 NN denotes Figure
T2498 15818-15819 -RRB- denotes )
T2499 15819-15820 . denotes .
T2500 15820-15928 sentence denotes The absence of coordinated spermatogenic progression beyond this stage is indicative of a pachytene arrest.
T2501 15821-15824 DT denotes The
T2502 15825-15832 NN denotes absence
T2503 15892-15894 VBZ denotes is
T2504 15833-15835 IN denotes of
T2505 15836-15847 VBN denotes coordinated
T2506 15862-15873 NN denotes progression
T2507 15848-15861 JJ denotes spermatogenic
T2508 15874-15880 IN denotes beyond
T2509 15881-15885 DT denotes this
T2510 15886-15891 NN denotes stage
T2511 15895-15905 JJ denotes indicative
T2512 15906-15908 IN denotes of
T2513 15909-15910 DT denotes a
T2514 15921-15927 NN denotes arrest
T2515 15911-15920 NN denotes pachytene
T2516 15927-15928 . denotes .
T2517 15928-15995 sentence denotes This was revealed more clearly by chromosome analysis (see below).
T2518 15929-15933 DT denotes This
T2519 15938-15946 VBN denotes revealed
T2520 15934-15937 VBD denotes was
T2521 15947-15951 RBR denotes more
T2522 15952-15959 RB denotes clearly
T2523 15960-15962 IN denotes by
T2524 15963-15973 NN denotes chromosome
T2525 15974-15982 NN denotes analysis
T2526 15983-15984 -LRB- denotes (
T2527 15984-15987 VB denotes see
T2528 15988-15993 RB denotes below
T2529 15993-15994 -RRB- denotes )
T2530 15994-15995 . denotes .
T2531 15995-16129 sentence denotes Some sections of adult seminiferous tubules contained postmeiotic spermatids (Figure 3G), although we saw no motile epididymal sperm.
T2532 15996-16000 DT denotes Some
T2533 16001-16009 NNS denotes sections
T2534 16040-16049 VBD denotes contained
T2535 16010-16012 IN denotes of
T2536 16013-16018 JJ denotes adult
T2537 16032-16039 NNS denotes tubules
T2538 16019-16031 JJ denotes seminiferous
T2539 16050-16061 JJ denotes postmeiotic
T2540 16062-16072 NNS denotes spermatids
T2541 16073-16074 -LRB- denotes (
T2542 16081-16083 NN denotes 3G
T2543 16074-16080 NN denotes Figure
T2544 16083-16084 -RRB- denotes )
T2545 16084-16086 , denotes ,
T2546 16086-16094 IN denotes although
T2547 16098-16101 VBD denotes saw
T2548 16095-16097 PRP denotes we
T2549 16102-16104 DT denotes no
T2550 16123-16128 NN denotes sperm
T2551 16105-16111 JJ denotes motile
T2552 16112-16122 JJ denotes epididymal
T2553 16128-16129 . denotes .
T2554 16129-16287 sentence denotes These drastic meiotic defects stand in contrast to yeast and C. elegans, in which deletion of Pch2 alone has minor effects on spore/gamete development [2,8].
T2555 16130-16135 DT denotes These
T2556 16152-16159 NNS denotes defects
T2557 16136-16143 JJ denotes drastic
T2558 16144-16151 JJ denotes meiotic
T2559 16160-16165 VBP denotes stand
T2560 16166-16168 IN denotes in
T2561 16169-16177 NN denotes contrast
T2562 16178-16180 IN denotes to
T2563 16181-16186 NN denotes yeast
T2564 16187-16190 CC denotes and
T2565 16191-16193 NNP denotes C.
T2566 16194-16201 NNP denotes elegans
T2567 16201-16203 , denotes ,
T2568 16203-16205 IN denotes in
T2569 16235-16238 VBZ denotes has
T2570 16206-16211 WDT denotes which
T2571 16212-16220 NN denotes deletion
T2572 16221-16223 IN denotes of
T2573 16224-16228 NN denotes Pch2
T2574 16229-16234 RB denotes alone
T2575 16239-16244 JJ denotes minor
T2576 16245-16252 NNS denotes effects
T2577 16253-16255 IN denotes on
T2578 16256-16261 NN denotes spore
T2579 16262-16268 NN denotes gamete
T2580 16261-16262 HYPH denotes /
T2581 16269-16280 NN denotes development
T2582 16281-16282 -LRB- denotes [
T2583 16284-16285 CD denotes 8
T2584 16282-16283 CD denotes 2
T2585 16283-16284 , denotes ,
T2586 16285-16286 -RRB- denotes ]
T2587 16286-16287 . denotes .
T2968 16289-16295 NN denotes TRIP13
T2969 16296-16305 JJ denotes Deficient
T2970 16295-16296 HYPH denotes -
T2971 16306-16315 NNS denotes Meiocytes
T2972 16316-16323 VBP denotes Undergo
T2973 16324-16334 JJ denotes Homologous
T2974 16346-16354 NN denotes Synapsis
T2975 16335-16345 NN denotes Chromosome
T2976 16355-16362 IN denotes Despite
T2977 16363-16366 DT denotes the
T2978 16367-16375 NN denotes Presence
T2979 16376-16378 IN denotes of
T2980 16379-16389 JJ denotes Unrepaired
T2981 16390-16394 NNS denotes DSBs
T2982 16395-16397 IN denotes in
T2983 16398-16407 NN denotes Pachynema
T2984 16407-16666 sentence denotes To better characterize the degree of meiotic progression in Trip13Gt/Gt spermatocytes, we immunostained chromosome spreads for SYCP3 and SYCP1, components of the axial/lateral elements and transverse filaments, respectively, of the synaptonemal complex (SC).
T2985 16408-16410 TO denotes To
T2986 16418-16430 VB denotes characterize
T2987 16411-16417 RBR denotes better
T2988 16498-16511 VBD denotes immunostained
T2989 16431-16434 DT denotes the
T2990 16435-16441 NN denotes degree
T2991 16442-16444 IN denotes of
T2992 16445-16452 JJ denotes meiotic
T2993 16453-16464 NN denotes progression
T2994 16465-16467 IN denotes in
T2995 16468-16476 NN denotes Trip13Gt
T2996 16477-16479 NN denotes Gt
T2997 16476-16477 HYPH denotes /
T2998 16480-16493 NNS denotes spermatocytes
T2999 16493-16495 , denotes ,
T3000 16495-16497 PRP denotes we
T3001 16512-16522 NN denotes chromosome
T3002 16523-16530 NNS denotes spreads
T3003 16531-16534 IN denotes for
T3004 16535-16540 NN denotes SYCP3
T3005 16541-16544 CC denotes and
T3006 16545-16550 NN denotes SYCP1
T3007 16550-16552 , denotes ,
T3008 16552-16562 NNS denotes components
T3009 16563-16565 IN denotes of
T3010 16566-16569 DT denotes the
T3011 16584-16592 NNS denotes elements
T3012 16570-16575 JJ denotes axial
T3013 16576-16583 JJ denotes lateral
T3014 16575-16576 HYPH denotes /
T3015 16593-16596 CC denotes and
T3016 16597-16607 JJ denotes transverse
T3017 16608-16617 NNS denotes filaments
T3018 16617-16619 , denotes ,
T3019 16619-16631 RB denotes respectively
T3020 16631-16633 , denotes ,
T3021 16633-16635 IN denotes of
T3022 16636-16639 DT denotes the
T3023 16653-16660 NN denotes complex
T3024 16640-16652 JJ denotes synaptonemal
T3025 16661-16662 -LRB- denotes (
T3026 16662-16664 NN denotes SC
T3027 16664-16665 -RRB- denotes )
T3028 16665-16666 . denotes .
T3029 16666-16898 sentence denotes Pachytene spermatocyte nuclei from postpubertal mutant testes could assemble normal SC cores and exhibited full synapsis of chromosomes as judged by colabeling of SYCP1 and SYCP3 along the full lengths of all autosomes (Figure 4A).
T3030 16667-16676 NN denotes Pachytene
T3031 16690-16696 NNS denotes nuclei
T3032 16677-16689 NN denotes spermatocyte
T3033 16735-16743 VB denotes assemble
T3034 16697-16701 IN denotes from
T3035 16702-16714 JJ denotes postpubertal
T3036 16722-16728 NNS denotes testes
T3037 16715-16721 NN denotes mutant
T3038 16729-16734 MD denotes could
T3039 16744-16750 JJ denotes normal
T3040 16754-16759 NNS denotes cores
T3041 16751-16753 NN denotes SC
T3042 16760-16763 CC denotes and
T3043 16764-16773 VBD denotes exhibited
T3044 16774-16778 JJ denotes full
T3045 16779-16787 NN denotes synapsis
T3046 16788-16790 IN denotes of
T3047 16791-16802 NNS denotes chromosomes
T3048 16803-16805 IN denotes as
T3049 16806-16812 VBN denotes judged
T3050 16813-16815 IN denotes by
T3051 16816-16826 VBG denotes colabeling
T3052 16827-16829 IN denotes of
T3053 16830-16835 NN denotes SYCP1
T3054 16836-16839 CC denotes and
T3055 16840-16845 NN denotes SYCP3
T3056 16846-16851 IN denotes along
T3057 16852-16855 DT denotes the
T3058 16861-16868 NNS denotes lengths
T3059 16856-16860 JJ denotes full
T3060 16869-16871 IN denotes of
T3061 16872-16875 DT denotes all
T3062 16876-16885 NNS denotes autosomes
T3063 16886-16887 -LRB- denotes (
T3064 16894-16896 NN denotes 4A
T3065 16887-16893 NN denotes Figure
T3066 16896-16897 -RRB- denotes )
T3067 16897-16898 . denotes .
T3068 16898-16992 sentence denotes Additionally, the X and Y chromosomes were normally synapsed at their pseudoautosomal region.
T3069 16899-16911 RB denotes Additionally
T3070 16951-16959 VBN denotes synapsed
T3071 16911-16913 , denotes ,
T3072 16913-16916 DT denotes the
T3073 16925-16936 NNS denotes chromosomes
T3074 16917-16918 NN denotes X
T3075 16919-16922 CC denotes and
T3076 16923-16924 NN denotes Y
T3077 16937-16941 VBD denotes were
T3078 16942-16950 RB denotes normally
T3079 16960-16962 IN denotes at
T3080 16963-16968 PRP$ denotes their
T3081 16985-16991 NN denotes region
T3082 16969-16984 JJ denotes pseudoautosomal
T3083 16991-16992 . denotes .
T3084 16992-17177 sentence denotes More prepubertal (17.5 d postpartum) mutant spermatocytes contained asynaptic or terminally asynapsed chromosomes than age-matched controls (62.5% versus 25%, respectively; Figure 4B).
T3085 16993-16997 RBR denotes More
T3086 17037-17050 NNS denotes spermatocytes
T3087 16998-17009 JJ denotes prepubertal
T3088 17010-17011 -LRB- denotes (
T3089 17011-17015 CD denotes 17.5
T3090 17016-17017 NN denotes d
T3091 17018-17028 NN denotes postpartum
T3092 17028-17029 -RRB- denotes )
T3093 17030-17036 NN denotes mutant
T3094 17051-17060 VBD denotes contained
T3095 17061-17070 JJ denotes asynaptic
T3096 17095-17106 NNS denotes chromosomes
T3097 17071-17073 CC denotes or
T3098 17074-17084 RB denotes terminally
T3099 17085-17094 VBN denotes asynapsed
T3100 17107-17111 IN denotes than
T3101 17112-17115 NN denotes age
T3102 17116-17123 VBN denotes matched
T3103 17115-17116 HYPH denotes -
T3104 17124-17132 NNS denotes controls
T3105 17133-17134 -LRB- denotes (
T3106 17173-17175 NN denotes 4B
T3107 17134-17138 CD denotes 62.5
T3108 17138-17139 NN denotes %
T3109 17140-17146 CC denotes versus
T3110 17147-17149 CD denotes 25
T3111 17149-17150 NN denotes %
T3125 17207-17209 IN denotes in
T3126 17210-17213 DT denotes the
T3127 17220-17224 NN denotes wave
T3128 17214-17219 JJ denotes first
T3129 17225-17227 IN denotes of
T3130 17228-17237 JJ denotes postnatal
T3131 17238-17253 NN denotes spermatogenesis
T3132 17254-17255 -LRB- denotes (
T3133 17262-17264 NN denotes 2D
T3134 17255-17261 NN denotes Figure
T3135 17265-17268 CC denotes and
T3136 17269-17271 NN denotes 2E
T3137 17271-17272 -RRB- denotes )
T3138 17272-17274 , denotes ,
T3139 17274-17280 RB denotes likely
T3140 17281-17288 VBN denotes related
T3141 17289-17291 IN denotes to
T3142 17292-17300 JJ denotes systemic
T3143 17315-17326 NN denotes retardation
T3144 17301-17314 JJ denotes developmental
T3145 17327-17328 -LRB- denotes (
T3146 17335-17337 NN denotes 2A
T3147 17328-17334 NN denotes Figure
T3148 17338-17341 CC denotes and
T3149 17342-17344 NN denotes 2B
T3150 17344-17345 -RRB- denotes )
T3151 17345-17346 . denotes .
T3152 17346-17635 sentence denotes Nevertheless, since Trip13Gt/Gt spermatocytes progress to pachynema with no gross SC abnormalities, and oocytes were eliminated soon after birth (a characteristic of DNA repair mutants [13]), this suggested that unrepaired DSBs are responsible for eventual meiotic arrest and elimination.
T3153 17347-17359 RB denotes Nevertheless
T3154 17544-17553 VBD denotes suggested
T3155 17359-17361 , denotes ,
T3156 17361-17366 IN denotes since
T3157 17393-17401 VBP denotes progress
T3158 17367-17375 NN denotes Trip13Gt
T3159 17376-17378 NN denotes Gt
T3160 17375-17376 HYPH denotes /
T3161 17379-17392 NNS denotes spermatocytes
T3162 17402-17404 IN denotes to
T3163 17405-17414 NN denotes pachynema
T3164 17415-17419 IN denotes with
T3165 17420-17422 DT denotes no
T3166 17432-17445 NNS denotes abnormalities
T3167 17423-17428 JJ denotes gross
T3168 17429-17431 NN denotes SC
T3169 17445-17447 , denotes ,
T3170 17447-17450 CC denotes and
T3171 17451-17458 NNS denotes oocytes
T3172 17464-17474 VBN denotes eliminated
T3173 17459-17463 VBD denotes were
T3174 17475-17479 RB denotes soon
T3175 17480-17485 IN denotes after
T3176 17486-17491 NN denotes birth
T3177 17492-17493 -LRB- denotes (
T3178 17495-17509 NN denotes characteristic
T3179 17493-17494 DT denotes a
T3180 17510-17512 IN denotes of
T3181 17513-17516 NN denotes DNA
T3182 17517-17523 NN denotes repair
T3183 17524-17531 NNS denotes mutants
T3184 17532-17533 -LRB- denotes [
T3185 17533-17535 CD denotes 13
T3186 17535-17536 -RRB- denotes ]
T3187 17536-17537 -RRB- denotes )
T3188 17537-17539 , denotes ,
T3189 17539-17543 DT denotes this
T3190 17554-17558 IN denotes that
T3191 17575-17578 VBP denotes are
T3192 17559-17569 JJ denotes unrepaired
T3193 17570-17574 NNS denotes DSBs
T3194 17579-17590 JJ denotes responsible
T3195 17591-17594 IN denotes for
T3196 17595-17603 JJ denotes eventual
T3197 17612-17618 NN denotes arrest
T3198 17604-17611 JJ denotes meiotic
T3199 17619-17622 CC denotes and
T3200 17623-17634 NN denotes elimination
T3201 17634-17635 . denotes .
T3202 17635-17636 sentence denotes
T3258 19612-19619 NNS denotes markers
T3259 19620-19624 WDT denotes that
T3260 19625-19628 VBP denotes are
T3261 19629-19639 JJ denotes diagnostic
T3262 19640-19642 IN denotes of
T3263 19643-19656 NN denotes recombination
T3264 19657-19660 CC denotes and
T3265 19661-19669 NN denotes synapsis
T3266 19669-19670 . denotes .
T3267 19670-19875 sentence denotes Recombination in Trip13Gt/Gt spermatocytes appeared to initiate normally as judged by the presence of γH2AX in leptonema (Figure S2A and S2B), which reflects the presence of meiotically induced DSBs [18].
T3268 19671-19684 NN denotes Recombination
T3269 19714-19722 VBD denotes appeared
T3270 19685-19687 IN denotes in
T3271 19688-19696 NN denotes Trip13Gt
T3272 19697-19699 NN denotes Gt
T3273 19696-19697 HYPH denotes /
T3274 19700-19713 NNS denotes spermatocytes
T3275 19723-19725 TO denotes to
T3276 19726-19734 VB denotes initiate
T3277 19735-19743 RB denotes normally
T3278 19744-19746 IN denotes as
T3279 19747-19753 VBN denotes judged
T3280 19754-19756 IN denotes by
T3281 19757-19760 DT denotes the
T3282 19761-19769 NN denotes presence
T3283 19770-19772 IN denotes of
T3284 19773-19778 NN denotes γH2AX
T3285 19779-19781 IN denotes in
T3286 19782-19791 NN denotes leptonema
T3287 19792-19793 -LRB- denotes (
T3288 19800-19803 NN denotes S2A
T3289 19793-19799 NN denotes Figure
T3290 19804-19807 CC denotes and
T3291 19808-19811 NN denotes S2B
T3292 19811-19812 -RRB- denotes )
T3293 19812-19814 , denotes ,
T3294 19814-19819 WDT denotes which
T3295 19820-19828 VBZ denotes reflects
T3296 19829-19832 DT denotes the
T3297 19833-19841 NN denotes presence
T3298 19842-19844 IN denotes of
T3299 19845-19856 RB denotes meiotically
T3300 19857-19864 VBN denotes induced
T3301 19865-19869 NNS denotes DSBs
T3302 19870-19871 -LRB- denotes [
T3303 19871-19873 CD denotes 18
T3304 19873-19874 -RRB- denotes ]
T3305 19874-19875 . denotes .
T3306 19875-20145 sentence denotes RAD51 and/or DMC1, components of early recombination nodules (ERNs), was also present as abundant foci in Trip13Gt/Gt zygotene spermatocytes (unpublished data; the anti-RAD51 antibody cross-reacts with DMC1), indicating that recombinational repair of DSBs is initiated.
T3307 19876-19881 NN denotes RAD51
T3308 19945-19948 VBD denotes was
T3309 19882-19885 CC denotes and
T3310 19885-19886 HYPH denotes /
T3311 19886-19888 CC denotes or
T3312 19889-19893 NN denotes DMC1
T3313 19893-19895 , denotes ,
T3314 19895-19905 NNS denotes components
T3315 19906-19908 IN denotes of
T3316 19909-19914 JJ denotes early
T3317 19915-19928 NN denotes recombination
T3318 19929-19936 NNS denotes nodules
T3319 19937-19938 -LRB- denotes (
T3320 19938-19942 NNS denotes ERNs
T3321 19942-19943 -RRB- denotes )
T3322 19943-19945 , denotes ,
T3323 19949-19953 RB denotes also
T3324 19954-19961 JJ denotes present
T3325 19962-19964 IN denotes as
T3326 19965-19973 JJ denotes abundant
T3327 19974-19978 NNS denotes foci
T3328 19979-19981 IN denotes in
T3329 19982-19990 NN denotes Trip13Gt
T3330 19991-19993 NN denotes Gt
T3331 19990-19991 HYPH denotes /
T3332 20003-20016 NNS denotes spermatocytes
T3333 19994-20002 NN denotes zygotene
T3334 20017-20018 -LRB- denotes (
T3335 20030-20034 NNS denotes data
T3336 20018-20029 JJ denotes unpublished
T3337 20034-20035 : denotes ;
T3338 20036-20039 DT denotes the
T3339 20051-20059 NN denotes antibody
T3340 20040-20050 JJ denotes anti-RAD51
T3341 20060-20072 VBZ denotes cross-reacts
T3342 20073-20077 IN denotes with
T3343 20078-20082 NN denotes DMC1
T3344 20082-20083 -RRB- denotes )
T3345 20083-20085 , denotes ,
T3346 20085-20095 VBG denotes indicating
T3347 20096-20100 IN denotes that
T3348 20135-20144 VBN denotes initiated
T3349 20101-20116 JJ denotes recombinational
T3350 20117-20123 NN denotes repair
T3351 20124-20126 IN denotes of
T3352 20127-20131 NNS denotes DSBs
T3353 20132-20134 VBZ denotes is
T3354 20144-20145 . denotes .
T3355 20145-20393 sentence denotes The cohesin complex, which is essential for completion and/or maintenance of synaptic associations, appeared to assemble normally as judged by immunolabeling for the meiosis-specific cohesins STAG3 (Figure S2C and S2D) and REC8 (unpublished data).
T3356 20146-20149 DT denotes The
T3357 20158-20165 NN denotes complex
T3358 20150-20157 NN denotes cohesin
T3359 20246-20254 VBD denotes appeared
T3360 20165-20167 , denotes ,
T3361 20167-20172 WDT denotes which
T3362 20173-20175 VBZ denotes is
T3363 20176-20185 JJ denotes essential
T3364 20186-20189 IN denotes for
T3365 20190-20200 NN denotes completion
T3366 20201-20204 CC denotes and
T3367 20204-20205 HYPH denotes /
T3368 20205-20207 CC denotes or
T3369 20208-20219 NN denotes maintenance
T3370 20220-20222 IN denotes of
T3371 20223-20231 JJ denotes synaptic
T3372 20232-20244 NNS denotes associations
T3373 20244-20246 , denotes ,
T3374 20255-20257 TO denotes to
T3375 20258-20266 VB denotes assemble
T3376 20267-20275 RB denotes normally
T3377 20276-20278 IN denotes as
T3378 20279-20285 VBN denotes judged
T3379 20286-20288 IN denotes by
T3380 20289-20303 VBG denotes immunolabeling
T3381 20304-20307 IN denotes for
T3382 20308-20311 DT denotes the
T3383 20338-20343 NN denotes STAG3
T3384 20312-20319 NN denotes meiosis
T3385 20320-20328 JJ denotes specific
T3386 20319-20320 HYPH denotes -
T3387 20329-20337 NNS denotes cohesins
T3388 20344-20345 -LRB- denotes (
T3389 20352-20355 NN denotes S2C
T3390 20345-20351 NN denotes Figure
T3391 20356-20359 CC denotes and
T3392 20360-20363 NN denotes S2D
T3393 20363-20364 -RRB- denotes )
T3394 20365-20368 CC denotes and
T3395 20369-20373 NN denotes REC8
T3396 20374-20375 -LRB- denotes (
T3397 20387-20391 NNS denotes data
T3398 20375-20386 JJ denotes unpublished
T3399 20391-20392 -RRB- denotes )
T3400 20392-20393 . denotes .
T3401 20393-20623 sentence denotes Because yeast PCH2 localizes to telomeres in a Sir3p-dependent manner, we tested for possible telomere defects by immunolabeling for TRF2, a component of a protein complex that plays an essential role in telomere protection [19].
T3402 20394-20401 IN denotes Because
T3403 20413-20422 VBZ denotes localizes
T3404 20402-20407 NN denotes yeast
T3405 20408-20412 NN denotes PCH2
T3406 20468-20474 VBD denotes tested
T3407 20423-20425 IN denotes to
T3408 20426-20435 NNS denotes telomeres
T3409 20436-20438 IN denotes in
T3410 20439-20440 DT denotes a
T3411 20457-20463 NN denotes manner
T3412 20441-20446 NN denotes Sir3p
T3413 20447-20456 JJ denotes dependent
T3414 20446-20447 HYPH denotes -
T3415 20463-20465 , denotes ,
T3416 20465-20467 PRP denotes we
T3417 20475-20478 IN denotes for
T3418 20479-20487 JJ denotes possible
T3419 20497-20504 NNS denotes defects
T3420 20488-20496 NN denotes telomere
T3421 20505-20507 IN denotes by
T3422 20508-20522 VBG denotes immunolabeling
T3423 20523-20526 IN denotes for
T3424 20527-20531 NN denotes TRF2
T3425 20531-20533 , denotes ,
T3426 20533-20534 DT denotes a
T3427 20535-20544 NN denotes component
T3428 20545-20547 IN denotes of
T3429 20548-20549 DT denotes a
T3430 20558-20565 NN denotes complex
T3431 20550-20557 NN denotes protein
T3432 20566-20570 WDT denotes that
T3433 20571-20576 VBZ denotes plays
T3434 20577-20579 DT denotes an
T3435 20590-20594 NN denotes role
T3436 20580-20589 JJ denotes essential
T3437 20595-20597 IN denotes in
T3438 20598-20606 NN denotes telomere
T3439 20607-20617 NN denotes protection
T3440 20618-20619 -LRB- denotes [
T3441 20619-20621 CD denotes 19
T3442 20621-20622 -RRB- denotes ]
T3443 20622-20623 . denotes .
T3444 20623-20745 sentence denotes It was localized to telomeres of both fully synapsed and telomerically asynaptic mutant chromosomes (Figure S2E and S2F).
T3445 20624-20626 PRP denotes It
T3446 20631-20640 VBN denotes localized
T3447 20627-20630 VBD denotes was
T3448 20641-20643 IN denotes to
T3449 20644-20653 NNS denotes telomeres
T3450 20654-20656 IN denotes of
T3451 20657-20661 CC denotes both
T3452 20668-20676 VBN denotes synapsed
T3453 20662-20667 RB denotes fully
T3454 20712-20723 NNS denotes chromosomes
T3455 20677-20680 CC denotes and
T3456 20681-20694 RB denotes telomerically
T3457 20695-20704 JJ denotes asynaptic
T3458 20705-20711 NN denotes mutant
T3459 20724-20725 -LRB- denotes (
T3460 20732-20735 NN denotes S2E
T3461 20725-20731 NN denotes Figure
T3462 20736-20739 CC denotes and
T3463 20740-20743 NN denotes S2F
T3464 20743-20744 -RRB- denotes )
T3465 20744-20745 . denotes .
T3466 20745-20918 sentence denotes Defects in DSB repair became apparent in pachynema upon probing of mutant spermatocyte nuclei with antibodies against molecules involved in various stages of recombination.
T3467 20746-20753 NNS denotes Defects
T3468 20768-20774 VBD denotes became
T3469 20754-20756 IN denotes in
T3470 20757-20760 NN denotes DSB
T3471 20761-20767 NN denotes repair
T3472 20775-20783 JJ denotes apparent
T3473 20784-20786 IN denotes in
T3474 20787-20796 NN denotes pachynema
T3475 20797-20801 IN denotes upon
T3476 20802-20809 NN denotes probing
T3477 20810-20812 IN denotes of
T3478 20813-20819 NN denotes mutant
T3479 20833-20839 NNS denotes nuclei
T3480 20820-20832 NN denotes spermatocyte
T3481 20840-20844 IN denotes with
T3482 20845-20855 NNS denotes antibodies
T3483 20856-20863 IN denotes against
T3484 20864-20873 NNS denotes molecules
T3485 20874-20882 VBN denotes involved
T3486 20883-20885 IN denotes in
T3487 20886-20893 JJ denotes various
T3488 20894-20900 NNS denotes stages
T3489 20901-20903 IN denotes of
T3490 20904-20917 NN denotes recombination
T3491 20917-20918 . denotes .
T3492 20918-21131 sentence denotes In >99% of Trip13Gt/Gt chromosome spreads, BLM helicase (Figure 4C and 4D), RAD51/DMC1 (Figure 4E and 4F), γH2AX (Figure 4G and 4H), and TOPBP1 (Figure 4I and 4J) all persisted abnormally on synapsed chromosomes.
T3493 20919-20921 IN denotes In
T3494 21086-21095 VBD denotes persisted
T3495 20922-20923 SYM denotes >
T3496 20923-20925 CD denotes 99
T3497 20925-20926 NN denotes %
T3498 20927-20929 IN denotes of
T3499 20930-20938 NN denotes Trip13Gt
T3500 20939-20941 NN denotes Gt
T3501 20938-20939 HYPH denotes /
T3502 20942-20952 NN denotes chromosome
T3503 20953-20960 NNS denotes spreads
T3504 20960-20962 , denotes ,
T3505 20962-20965 NN denotes BLM
T3506 20966-20974 NN denotes helicase
T3507 20975-20976 -LRB- denotes (
T3508 20983-20985 NN denotes 4C
T3509 20976-20982 NN denotes Figure
T3510 20986-20989 CC denotes and
T3511 20990-20992 NN denotes 4D
T3512 20992-20993 -RRB- denotes )
T3513 20993-20995 , denotes ,
T3514 20995-21000 NN denotes RAD51
T3515 21001-21005 NN denotes DMC1
T3516 21000-21001 HYPH denotes /
T3517 21006-21007 -LRB- denotes (
T3518 21014-21016 NN denotes 4E
T3519 21007-21013 NN denotes Figure
T3520 21017-21020 CC denotes and
T3521 21021-21023 NN denotes 4F
T3522 21023-21024 -RRB- denotes )
T3523 21024-21026 , denotes ,
T3524 21026-21031 NN denotes γH2AX
T3525 21032-21033 -LRB- denotes (
T3526 21040-21042 NN denotes 4G
T3527 21033-21039 NN denotes Figure
T3528 21043-21046 CC denotes and
T3529 21047-21049 NN denotes 4H
T3530 21049-21050 -RRB- denotes )
T3531 21050-21052 , denotes ,
T3532 21052-21055 CC denotes and
T3533 21056-21062 NN denotes TOPBP1
T3534 21063-21064 -LRB- denotes (
T3535 21064-21070 NN denotes Figure
T3536 21071-21073 NN denotes 4I
T3537 21074-21077 CC denotes and
T3538 21078-21080 NN denotes 4J
T3539 21080-21081 -RRB- denotes )
T3540 21082-21085 DT denotes all
T3541 21096-21106 RB denotes abnormally
T3542 21107-21109 IN denotes on
T3543 21110-21118 VBN denotes synapsed
T3544 21119-21130 NNS denotes chromosomes
T3545 21130-21131 . denotes .
T3546 21131-21349 sentence denotes For RAD51/DMC1, mutant pachytene spermatocytes contained 138 ± 6 foci (compared to 11 ± 3 foci in wild type, most of which were on the XY body), down from 218 ± 13 in zygonema (compared to 220 ± 13 foci in wild type).
T3547 21132-21135 IN denotes For
T3548 21179-21188 VBD denotes contained
T3549 21136-21141 NN denotes RAD51
T3550 21142-21146 NN denotes DMC1
T3551 21141-21142 HYPH denotes /
T3552 21146-21148 , denotes ,
T3553 21148-21154 NN denotes mutant
T3554 21155-21164 NN denotes pachytene
T3555 21165-21178 NNS denotes spermatocytes
T3556 21189-21192 CD denotes 138
T3557 21195-21196 CD denotes 6
T3558 21193-21194 SYM denotes ±
T3559 21197-21201 NNS denotes foci
T3560 21202-21203 -LRB- denotes (
T3561 21203-21211 VBN denotes compared
T3562 21212-21214 IN denotes to
T3563 21215-21217 CD denotes 11
T3564 21220-21221 CD denotes 3
T3565 21218-21219 SYM denotes ±
T3566 21222-21226 NNS denotes foci
T3567 21227-21229 IN denotes in
T3568 21230-21234 JJ denotes wild
T3569 21235-21239 NN denotes type
T3570 21239-21241 , denotes ,
T3571 21241-21245 JJS denotes most
T3572 21255-21259 VBD denotes were
T3573 21246-21248 IN denotes of
T3574 21249-21254 WDT denotes which
T3575 21260-21262 IN denotes on
T3576 21263-21266 DT denotes the
T3577 21270-21274 NN denotes body
T3578 21267-21269 NN denotes XY
T3579 21274-21275 -RRB- denotes )
T3580 21275-21277 , denotes ,
T3581 21277-21281 RB denotes down
T3582 21282-21286 IN denotes from
T3583 21287-21290 CD denotes 218
T3584 21293-21295 CD denotes 13
T3585 21291-21292 SYM denotes ±
T3586 21296-21298 IN denotes in
T3587 21299-21307 NN denotes zygonema
T3588 21308-21309 -LRB- denotes (
T3589 21309-21317 VBN denotes compared
T3590 21318-21320 IN denotes to
T3591 21321-21324 CD denotes 220
T3592 21327-21329 CD denotes 13
T3593 21325-21326 SYM denotes ±
T3594 21330-21334 NNS denotes foci
T3595 21335-21337 IN denotes in
T3596 21338-21342 JJ denotes wild
T3597 21343-21347 NN denotes type
T3598 21347-21348 -RRB- denotes )
T3599 21348-21349 . denotes .
T3600 21349-21460 sentence denotes TOPBP1 is a DNA damage–checkpoint protein involved in ATM protein–dependent activation of ATR protein [20,21].
T3601 21350-21356 NN denotes TOPBP1
T3602 21357-21359 VBZ denotes is
T3603 21360-21361 DT denotes a
T3604 21384-21391 NN denotes protein
T3605 21362-21365 NN denotes DNA
T3606 21366-21372 NN denotes damage
T3607 21373-21383 NN denotes checkpoint
T3608 21372-21373 HYPH denotes –
T3609 21392-21400 VBN denotes involved
T3610 21401-21403 IN denotes in
T3611 21404-21407 NN denotes ATM
T3612 21408-21415 NN denotes protein
T3613 21416-21425 JJ denotes dependent
T3614 21415-21416 HYPH denotes –
T3615 21426-21436 NN denotes activation
T3616 21437-21439 IN denotes of
T3617 21440-21443 NN denotes ATR
T3618 21444-21451 NN denotes protein
T3619 21452-21453 -LRB- denotes [
T3620 21456-21458 CD denotes 21
T3621 21453-21455 CD denotes 20
T3622 21455-21456 , denotes ,
T3623 21458-21459 -RRB- denotes ]
T3624 21459-21460 . denotes .
T3625 21460-21538 sentence denotes It binds sites of DSBs and unsynapsed regions of meiotic chromosomes [22,23].
T3626 21461-21463 PRP denotes It
T3627 21464-21469 VBZ denotes binds
T3628 21470-21475 NNS denotes sites
T3629 21476-21478 IN denotes of
T3630 21479-21483 NNS denotes DSBs
T3631 21484-21487 CC denotes and
T3632 21488-21498 JJ denotes unsynapsed
T3633 21499-21506 NNS denotes regions
T3634 21507-21509 IN denotes of
T3635 21510-21517 JJ denotes meiotic
T3636 21518-21529 NNS denotes chromosomes
T3637 21530-21531 -LRB- denotes [
T3638 21534-21536 CD denotes 23
T3639 21531-21533 CD denotes 22
T3640 21533-21534 , denotes ,
T3641 21536-21537 -RRB- denotes ]
T3642 21537-21538 . denotes .
T3643 21538-21694 sentence denotes BLM has been reported to colocalize with markers (RPA and MSH4) of recombination at sites distinct from those that become resolved as crossovers (CO) [24].
T3644 21539-21542 NN denotes BLM
T3645 21552-21560 VBN denotes reported
T3646 21543-21546 VBZ denotes has
T3647 21547-21551 VBN denotes been
T3648 21561-21563 TO denotes to
T3649 21564-21574 VB denotes colocalize
T3650 21575-21579 IN denotes with
T3651 21580-21587 NNS denotes markers
T3652 21589-21592 NN denotes RPA
T3653 21588-21589 -LRB- denotes (
T3654 21593-21596 CC denotes and
T3655 21597-21601 NN denotes MSH4
T3656 21601-21602 -RRB- denotes )
T3657 21603-21605 IN denotes of
T3658 21606-21619 NN denotes recombination
T3659 21620-21622 IN denotes at
T3660 21623-21628 NNS denotes sites
T3661 21629-21637 JJ denotes distinct
T3662 21638-21642 IN denotes from
T3663 21643-21648 DT denotes those
T3664 21649-21653 WDT denotes that
T3665 21654-21660 VBP denotes become
T3666 21661-21669 JJ denotes resolved
T3667 21670-21672 IN denotes as
T3668 21673-21683 NNS denotes crossovers
T3669 21684-21685 -LRB- denotes (
T3670 21685-21687 NN denotes CO
T3671 21687-21688 -RRB- denotes )
T3672 21689-21690 -LRB- denotes [
T3673 21690-21692 CD denotes 24
T3674 21692-21693 -RRB- denotes ]
T3675 21693-21694 . denotes .
T3676 21694-21885 sentence denotes We therefore assessed the distribution of RPA, the ssDNA binding protein, which is normally present at focal sites of synapsing meiotic chromosomes before disappearing in mid-pachynema [25].
T3677 21695-21697 PRP denotes We
T3678 21708-21716 VBD denotes assessed
T3679 21698-21707 RB denotes therefore
T3680 21717-21720 DT denotes the
T3681 21721-21733 NN denotes distribution
T3682 21734-21736 IN denotes of
T3683 21737-21740 NN denotes RPA
T3684 21740-21742 , denotes ,
T3685 21742-21745 DT denotes the
T3686 21760-21767 NN denotes protein
T3687 21746-21751 NN denotes ssDNA
T3688 21752-21759 NN denotes binding
T3689 21767-21769 , denotes ,
T3690 21769-21774 WDT denotes which
T3691 21775-21777 VBZ denotes is
T3692 21778-21786 RB denotes normally
T3693 21787-21794 JJ denotes present
T3694 21795-21797 IN denotes at
T3695 21798-21803 JJ denotes focal
T3696 21804-21809 NNS denotes sites
T3697 21810-21812 IN denotes of
T3698 21813-21822 VBG denotes synapsing
T3699 21831-21842 NNS denotes chromosomes
T3700 21823-21830 JJ denotes meiotic
T3701 21843-21849 IN denotes before
T3702 21850-21862 VBG denotes disappearing
T3703 21863-21865 IN denotes in
T3704 21866-21879 NN denotes mid-pachynema
T3705 21880-21881 -LRB- denotes [
T3706 21881-21883 CD denotes 25
T3707 21883-21884 -RRB- denotes ]
T3708 21884-21885 . denotes .
T3709 21885-21952 sentence denotes It is thought to bind D-loops of recombination intermediates [26].
T3710 21886-21888 PRP denotes It
T3711 21892-21899 VBN denotes thought
T3712 21889-21891 VBZ denotes is
T3713 21900-21902 TO denotes to
T3714 21903-21907 VB denotes bind
T3715 21908-21909 NN denotes D
T3716 21910-21915 NNS denotes loops
T3717 21909-21910 HYPH denotes -
T3718 21916-21918 IN denotes of
T3719 21919-21932 NN denotes recombination
T3720 21933-21946 NNS denotes intermediates
T3721 21947-21948 -LRB- denotes [
T3722 21948-21950 CD denotes 26
T3723 21950-21951 -RRB- denotes ]
T3724 21951-21952 . denotes .
T3725 21952-22023 sentence denotes RPA also persisted on pachytene mutant chromosomes (Figure 4K and 4L).
T3726 21953-21956 NN denotes RPA
T3727 21962-21971 VBD denotes persisted
T3728 21957-21961 RB denotes also
T3729 21972-21974 IN denotes on
T3730 21975-21984 NN denotes pachytene
T3731 21992-22003 NNS denotes chromosomes
T3732 21985-21991 NN denotes mutant
T3733 22004-22005 -LRB- denotes (
T3734 22012-22014 NN denotes 4K
T3735 22005-22011 NN denotes Figure
T3736 22015-22018 CC denotes and
T3737 22019-22021 NN denotes 4L
T3738 22021-22022 -RRB- denotes )
T3739 22022-22023 . denotes .
T3740 22023-22173 sentence denotes These data indicate that unrepaired DSBs, or unresolved recombination intermediates, remain in pachynema and activate a DNA damage checkpoint system.
T3741 22024-22029 DT denotes These
T3742 22030-22034 NNS denotes data
T3743 22035-22043 VBP denotes indicate
T3744 22044-22048 IN denotes that
T3745 22109-22115 VBP denotes remain
T3746 22049-22059 JJ denotes unrepaired
T3747 22060-22064 NNS denotes DSBs
T3748 22064-22066 , denotes ,
T3749 22066-22068 CC denotes or
T3750 22069-22079 JJ denotes unresolved
T3751 22094-22107 NNS denotes intermediates
T3752 22080-22093 NN denotes recombination
T3753 22107-22109 , denotes ,
T3754 22116-22118 IN denotes in
T3755 22119-22128 NN denotes pachynema
T3756 22129-22132 CC denotes and
T3757 22133-22141 VBP denotes activate
T3758 22142-22143 DT denotes a
T3759 22166-22172 NN denotes system
T3760 22144-22147 NN denotes DNA
T3761 22148-22154 NN denotes damage
T3762 22155-22165 NN denotes checkpoint
T3763 22172-22173 . denotes .
T3764 22173-22411 sentence denotes It should be noted that chromosomes affected by meiotic sex chromosome inactivation (MSCI) and meiotic silencing of unpaired chromatin (MSUC) are heavily stained by antibodies for several DSB repair-associated molecules, including γH2AX.
T3765 22174-22176 PRP denotes It
T3766 22187-22192 VBN denotes noted
T3767 22177-22183 MD denotes should
T3768 22184-22186 VB denotes be
T3769 22193-22197 IN denotes that
T3770 22328-22335 VBN denotes stained
T3771 22198-22209 NNS denotes chromosomes
T3772 22210-22218 VBN denotes affected
T3773 22219-22221 IN denotes by
T3774 22222-22229 JJ denotes meiotic
T3775 22245-22257 NN denotes inactivation
T3776 22230-22233 NN denotes sex
T3777 22234-22244 NN denotes chromosome
T3778 22258-22259 -LRB- denotes (
T3779 22259-22263 NN denotes MSCI
T3780 22263-22264 -RRB- denotes )
T3781 22265-22268 CC denotes and
T3782 22269-22276 JJ denotes meiotic
T3783 22277-22286 NN denotes silencing
T3784 22287-22289 IN denotes of
T3785 22290-22298 JJ denotes unpaired
T3786 22299-22308 NN denotes chromatin
T3787 22309-22310 -LRB- denotes (
T3788 22310-22314 NN denotes MSUC
T3789 22314-22315 -RRB- denotes )
T3790 22316-22319 VBP denotes are
T3791 22320-22327 RB denotes heavily
T3792 22336-22338 IN denotes by
T3793 22339-22349 NNS denotes antibodies
T3794 22350-22353 IN denotes for
T3795 22354-22361 JJ denotes several
T3796 22384-22393 NNS denotes molecules
T3797 22362-22365 NN denotes DSB
T3798 22366-22372 NN denotes repair
T3799 22373-22383 VBN denotes associated
T3800 22372-22373 HYPH denotes -
T3801 22393-22395 , denotes ,
T3802 22395-22404 VBG denotes including
T3803 22405-22410 NN denotes γH2AX
T3804 22410-22411 . denotes .
T3805 22411-22491 sentence denotes H2AX phosphorylation due to MSCI and MSUC is conducted by ATR, not ATM [27–29].
T3806 22412-22416 NN denotes H2AX
T3807 22417-22432 NN denotes phosphorylation
T3808 22457-22466 VBN denotes conducted
T3809 22433-22436 IN denotes due
T3810 22437-22439 IN denotes to
T3811 22440-22444 NN denotes MSCI
T3812 22445-22448 CC denotes and
T3813 22449-22453 NN denotes MSUC
T3814 22454-22456 VBZ denotes is
T3815 22467-22469 IN denotes by
T3816 22470-22473 NN denotes ATR
T3817 22473-22475 , denotes ,
T3818 22475-22478 CC denotes not
T3819 22479-22482 NN denotes ATM
T3820 22483-22484 -LRB- denotes [
T3821 22484-22486 CD denotes 27
T3822 22486-22487 SYM denotes –
T3823 22487-22489 CD denotes 29
T3824 22489-22490 -RRB- denotes ]
T3825 22490-22491 . denotes .
T3826 22491-22749 sentence denotes Since mutant chromosomes are fully synapsed, and MSUC is known to occur only as a result of asynapsis, the decoration of Trip13Gt/Gt chromosomes with DNA repair markers is probably attributable to incomplete DNA repair rather than transcriptional silencing.
T3827 22492-22497 IN denotes Since
T3828 22527-22535 VBN denotes synapsed
T3829 22498-22504 NN denotes mutant
T3830 22505-22516 NNS denotes chromosomes
T3831 22517-22520 VBP denotes are
T3832 22521-22526 RB denotes fully
T3833 22661-22663 VBZ denotes is
T3834 22535-22537 , denotes ,
T3835 22537-22540 CC denotes and
T3836 22541-22545 NN denotes MSUC
T3837 22549-22554 VBN denotes known
T3838 22546-22548 VBZ denotes is
T3839 22555-22557 TO denotes to
T3840 22558-22563 VB denotes occur
T3841 22564-22568 RB denotes only
T3842 22569-22571 IN denotes as
T3843 22572-22573 DT denotes a
T3844 22574-22580 NN denotes result
T3845 22581-22583 IN denotes of
T3846 22584-22593 NN denotes asynapsis
T3847 22593-22595 , denotes ,
T3848 22595-22598 DT denotes the
T3849 22599-22609 NN denotes decoration
T3850 22610-22612 IN denotes of
T3851 22613-22621 NN denotes Trip13Gt
T3852 22622-22624 NN denotes Gt
T3853 22621-22622 HYPH denotes /
T3854 22625-22636 NNS denotes chromosomes
T3855 22637-22641 IN denotes with
T3856 22642-22645 NN denotes DNA
T3857 22646-22652 NN denotes repair
T3858 22653-22660 NNS denotes markers
T3859 22664-22672 RB denotes probably
T3860 22673-22685 JJ denotes attributable
T3861 22686-22688 IN denotes to
T3862 22689-22699 JJ denotes incomplete
T3863 22704-22710 NN denotes repair
T3864 22700-22703 NN denotes DNA
T3865 22711-22717 RB denotes rather
T3866 22718-22722 IN denotes than
T3867 22723-22738 JJ denotes transcriptional
T3868 22739-22748 NN denotes silencing
T3869 22748-22749 . denotes .
T3870 22749-23110 sentence denotes Consistent with the presence of rare (<1%) Trip13Gt/Gt pachytene spermatocytes devoid of persistent DNA repair markers, and testis histology showing some degree of postmeiotic progression (Figure 3G), we observed both diplotene nuclei that lacked autosomal RAD51/DMC1 and γH2AX (Figure S3A–S3D), and also metaphase I spreads with 20 bivalents (Figure S3E–S3F).
T3871 22750-22760 JJ denotes Consistent
T3872 22954-22962 VBD denotes observed
T3873 22761-22765 IN denotes with
T3874 22766-22769 DT denotes the
T3875 22770-22778 NN denotes presence
T3876 22779-22781 IN denotes of
T3877 22782-22786 JJ denotes rare
T3878 22815-22828 NNS denotes spermatocytes
T3879 22787-22788 -LRB- denotes (
T3880 22790-22791 NN denotes %
T3881 22788-22789 SYM denotes <
T3882 22789-22790 CD denotes 1
T3883 22791-22792 -RRB- denotes )
T3884 22793-22801 NN denotes Trip13Gt
T3885 22802-22804 NN denotes Gt
T3886 22801-22802 HYPH denotes /
T3887 22805-22814 NN denotes pachytene
T3888 22829-22835 JJ denotes devoid
T3889 22836-22838 IN denotes of
T3890 22839-22849 JJ denotes persistent
T3891 22861-22868 NNS denotes markers
T3892 22850-22853 NN denotes DNA
T3893 22854-22860 NN denotes repair
T3894 22868-22870 , denotes ,
T3895 22870-22873 CC denotes and
T3896 22874-22880 NN denotes testis
T3897 22881-22890 NN denotes histology
T3898 22891-22898 VBG denotes showing
T3899 22899-22903 DT denotes some
T3900 22904-22910 NN denotes degree
T3901 22911-22913 IN denotes of
T3902 22914-22925 JJ denotes postmeiotic
T3903 22926-22937 NN denotes progression
T3904 22938-22939 -LRB- denotes (
T3905 22946-22948 NN denotes 3G
T3906 22939-22945 NN denotes Figure
T3907 22948-22949 -RRB- denotes )
T3908 22949-22951 , denotes ,
T3909 22951-22953 PRP denotes we
T3910 22963-22967 CC denotes both
T3911 22978-22984 NNS denotes nuclei
T3912 22968-22977 NN denotes diplotene
T3913 22985-22989 WDT denotes that
T3914 22990-22996 VBD denotes lacked
T3915 22997-23006 JJ denotes autosomal
T3916 23013-23017 NN denotes DMC1
T3917 23007-23012 NN denotes RAD51
T3918 23012-23013 HYPH denotes /
T3919 23018-23021 CC denotes and
T3920 23022-23027 NN denotes γH2AX
T3921 23028-23029 -LRB- denotes (
T3922 23040-23043 NN denotes S3D
T3923 23029-23035 NN denotes Figure
T3924 23036-23039 NN denotes S3A
T3925 23039-23040 SYM denotes –
T3926 23043-23044 -RRB- denotes )
T3927 23044-23046 , denotes ,
T3928 23046-23049 CC denotes and
T3929 23050-23054 RB denotes also
T3930 23055-23064 NN denotes metaphase
T3931 23067-23074 NNS denotes spreads
T3932 23065-23066 CD denotes I
T3933 23075-23079 IN denotes with
T3934 23080-23082 CD denotes 20
T3935 23083-23092 NNS denotes bivalents
T3936 23093-23094 -LRB- denotes (
T3937 23105-23108 NN denotes S3F
T3938 23094-23100 NN denotes Figure
T3939 23101-23104 NN denotes S3E
T3940 23104-23105 SYM denotes –
T3941 23108-23109 -RRB- denotes )
T3942 23109-23110 . denotes .
T3943 23110-23260 sentence denotes Since Trip13Gt may not be a complete null, these diplotene and metaphase I spermatocytes might arise by virtue of having sufficient wild-type TRIP13.
T3944 23111-23116 IN denotes Since
T3945 23134-23136 VB denotes be
T3946 23117-23125 NN denotes Trip13Gt
T3947 23126-23129 MD denotes may
T3948 23130-23133 RB denotes not
T3949 23206-23211 VB denotes arise
T3950 23137-23138 DT denotes a
T3951 23148-23152 NN denotes null
T3952 23139-23147 JJ denotes complete
T3953 23152-23154 , denotes ,
T3954 23154-23159 DT denotes these
T3955 23186-23199 NNS denotes spermatocytes
T3956 23160-23169 NN denotes diplotene
T3957 23170-23173 CC denotes and
T3958 23174-23183 NN denotes metaphase
T3959 23184-23185 CD denotes I
T3960 23200-23205 MD denotes might
T3961 23212-23214 IN denotes by
T3962 23215-23221 NN denotes virtue
T3963 23222-23224 IN denotes of
T3964 23225-23231 VBG denotes having
T3965 23232-23242 JJ denotes sufficient
T3966 23253-23259 NN denotes TRIP13
T3967 23243-23247 JJ denotes wild
T3968 23248-23252 NN denotes type
T3969 23247-23248 HYPH denotes -
T3970 23259-23260 . denotes .
T4133 23262-23264 NN denotes CO
T4134 23265-23275 VBN denotes Associated
T4135 23264-23265 HYPH denotes -
T4136 23276-23283 NNS denotes Markers
T4137 23284-23290 VBP denotes Appear
T4138 23291-23299 RB denotes Normally
T4139 23300-23302 IN denotes in
T4140 23303-23306 DT denotes the
T4141 23307-23314 NN denotes Absence
T4142 23315-23317 IN denotes of
T4143 23318-23324 NN denotes TRIP13
T4144 23324-23503 sentence denotes The persistence of BLM on Trip13Gt/Gt spermatocyte chromosomes suggests that at least a subset of the unrepaired DSBs correspond to sites of defective NCO recombinational repair.
T4145 23325-23328 DT denotes The
T4146 23329-23340 NN denotes persistence
T4147 23388-23396 VBZ denotes suggests
T4148 23341-23343 IN denotes of
T4149 23344-23347 NN denotes BLM
T4150 23348-23350 IN denotes on
T4151 23351-23359 NN denotes Trip13Gt
T4152 23360-23362 NN denotes Gt
T4153 23359-23360 HYPH denotes /
T4154 23363-23375 NN denotes spermatocyte
T4155 23376-23387 NNS denotes chromosomes
T4156 23397-23401 IN denotes that
T4157 23443-23453 VBP denotes correspond
T4158 23402-23404 RB denotes at
T4159 23405-23410 RBS denotes least
T4160 23413-23419 NN denotes subset
T4161 23411-23412 DT denotes a
T4162 23420-23422 IN denotes of
T4163 23423-23426 DT denotes the
T4164 23438-23442 NNS denotes DSBs
T4165 23427-23437 JJ denotes unrepaired
T4166 23454-23456 IN denotes to
T4167 23457-23462 NNS denotes sites
T4168 23463-23465 IN denotes of
T4169 23466-23475 JJ denotes defective
T4170 23496-23502 NN denotes repair
T4171 23476-23479 NN denotes NCO
T4172 23480-23495 JJ denotes recombinational
T4173 23502-23503 . denotes .
T4174 23503-23741 sentence denotes To assess whether CO recombination occurs in the mutant, we examined the distribution of the mismatch repair proteins MLH1 and MLH3, which are normally detectable as foci in mid-late pachynema and mark the locations of chiasmata [30,31].
T4175 23504-23506 TO denotes To
T4176 23507-23513 VB denotes assess
T4177 23564-23572 VBD denotes examined
T4178 23514-23521 IN denotes whether
T4179 23539-23545 VBZ denotes occurs
T4180 23522-23524 NN denotes CO
T4181 23525-23538 NN denotes recombination
T4182 23546-23548 IN denotes in
T4183 23549-23552 DT denotes the
T4184 23553-23559 NN denotes mutant
T4185 23559-23561 , denotes ,
T4186 23561-23563 PRP denotes we
T4187 23573-23576 DT denotes the
T4188 23577-23589 NN denotes distribution
T4189 23590-23592 IN denotes of
T4190 23593-23596 DT denotes the
T4191 23613-23621 NN denotes proteins
T4192 23597-23605 NN denotes mismatch
T4193 23606-23612 NN denotes repair
T4194 23622-23626 NN denotes MLH1
T4195 23627-23630 CC denotes and
T4196 23631-23635 NN denotes MLH3
T4197 23635-23637 , denotes ,
T4198 23637-23642 WDT denotes which
T4199 23643-23646 VBP denotes are
T4200 23647-23655 RB denotes normally
T4201 23656-23666 JJ denotes detectable
T4202 23667-23669 IN denotes as
T4203 23670-23674 NNS denotes foci
T4204 23675-23677 IN denotes in
T4205 23678-23681 JJ denotes mid
T4206 23682-23686 JJ denotes late
T4207 23681-23682 SYM denotes -
T4208 23687-23696 NN denotes pachynema
T4209 23697-23700 CC denotes and
T4210 23701-23705 VBP denotes mark
T4211 23706-23709 DT denotes the
T4212 23710-23719 NNS denotes locations
T4213 23720-23722 IN denotes of
T4214 23723-23732 NNS denotes chiasmata
T4215 23733-23734 -LRB- denotes [
T4216 23737-23739 CD denotes 31
T4217 23734-23736 CD denotes 30
T4218 23736-23737 , denotes ,
T4219 23739-23740 -RRB- denotes ]
T4220 23740-23741 . denotes .
T4221 23741-23959 sentence denotes Remarkably, MLH1/3 foci were formed; we observed 1–2 foci/chromosome as in wild type and at typical overall levels (MLH3 = 23 ± 2, N = 10; [30,32]) on mid-late pachytene chromosomes (Figure 4M and 4N; MLH1 not shown).
T4222 23742-23752 RB denotes Remarkably
T4223 23771-23777 VBN denotes formed
T4224 23752-23754 , denotes ,
T4225 23754-23758 NN denotes MLH1
T4226 23761-23765 NNS denotes foci
T4227 23758-23759 HYPH denotes /
T4228 23759-23760 CD denotes 3
T4229 23766-23770 VBD denotes were
T4230 23782-23790 VBD denotes observed
T4231 23777-23778 : denotes ;
T4232 23779-23781 PRP denotes we
T4233 23791-23792 CD denotes 1
T4234 23793-23794 CD denotes 2
T4235 23792-23793 SYM denotes –
T4236 23795-23799 NNS denotes foci
T4237 23799-23800 SYM denotes /
T4238 23800-23810 NN denotes chromosome
T4239 23811-23813 IN denotes as
T4240 23814-23816 IN denotes in
T4241 23817-23821 JJ denotes wild
T4242 23822-23826 NN denotes type
T4243 23827-23830 CC denotes and
T4244 23831-23833 IN denotes at
T4245 23834-23841 JJ denotes typical
T4246 23850-23856 NNS denotes levels
T4247 23842-23849 JJ denotes overall
T4248 23857-23858 -LRB- denotes (
T4249 23877-23879 CD denotes 10
T4250 23858-23862 NN denotes MLH3
T4251 23870-23871 CD denotes 2
T4252 23863-23864 SYM denotes =
T4253 23865-23867 CD denotes 23
T4254 23868-23869 SYM denotes ±
T4255 23871-23873 , denotes ,
T4256 23873-23874 NN denotes N
T4257 23875-23876 SYM denotes =
T4258 23879-23880 : denotes ;
T4259 23881-23882 -LRB- denotes [
T4260 23885-23887 CD denotes 32
T4261 23882-23884 CD denotes 30
T4262 23884-23885 , denotes ,
T4263 23887-23888 -RRB- denotes ]
T4264 23888-23889 -RRB- denotes )
T4265 23890-23892 IN denotes on
T4266 23893-23896 JJ denotes mid
T4267 23897-23901 JJ denotes late
T4268 23896-23897 SYM denotes -
T4269 23902-23911 NN denotes pachytene
T4270 23912-23923 NNS denotes chromosomes
T4271 23924-23925 -LRB- denotes (
T4272 23932-23934 NN denotes 4M
T4273 23925-23931 NN denotes Figure
T4274 23935-23938 CC denotes and
T4275 23939-23941 NN denotes 4N
T4276 23941-23942 : denotes ;
T4277 23943-23947 NN denotes MLH1
T4278 23952-23957 VBN denotes shown
T4279 23948-23951 RB denotes not
T4280 23957-23958 -RRB- denotes )
T4281 23958-23959 . denotes .
T4282 23959-24227 sentence denotes Since <1% of Trip13Gt/Gt pachytene nuclei had normal repair (as judged by absence of persistent DSB repair markers; see above), but most of the pachytene nuclei had MLH1/3 foci, it was unlikely that the MLH1/3 foci formed only on chromosomes with fully repaired DSBs.
T4283 23960-23965 IN denotes Since
T4284 24002-24005 VBD denotes had
T4285 23966-23967 SYM denotes <
T4286 23967-23968 CD denotes 1
T4287 23968-23969 NN denotes %
T4288 23970-23972 IN denotes of
T4289 23973-23981 NN denotes Trip13Gt
T4290 23982-23984 NN denotes Gt
T4291 23981-23982 HYPH denotes /
T4292 23985-23994 NN denotes pachytene
T4293 23995-24001 NNS denotes nuclei
T4294 24141-24144 VBD denotes was
T4295 24006-24012 JJ denotes normal
T4296 24013-24019 NN denotes repair
T4297 24020-24021 -LRB- denotes (
T4298 24076-24079 VB denotes see
T4299 24021-24023 IN denotes as
T4300 24024-24030 VBN denotes judged
T4301 24031-24033 IN denotes by
T4302 24034-24041 NN denotes absence
T4303 24042-24044 IN denotes of
T4304 24045-24055 JJ denotes persistent
T4305 24067-24074 NNS denotes markers
T4306 24056-24059 NN denotes DSB
T4307 24060-24066 NN denotes repair
T4308 24074-24075 : denotes ;
T4309 24080-24085 RB denotes above
T4310 24085-24086 -RRB- denotes )
T4311 24086-24088 , denotes ,
T4312 24088-24091 CC denotes but
T4313 24092-24096 JJS denotes most
T4314 24121-24124 VBD denotes had
T4315 24097-24099 IN denotes of
T4316 24100-24103 DT denotes the
T4317 24114-24120 NNS denotes nuclei
T4318 24104-24113 NN denotes pachytene
T4319 24125-24129 NN denotes MLH1
T4320 24132-24136 NNS denotes foci
T4321 24129-24130 HYPH denotes /
T4322 24130-24131 CD denotes 3
T4323 24136-24138 , denotes ,
T4324 24138-24140 PRP denotes it
T4325 24145-24153 JJ denotes unlikely
T4326 24154-24158 IN denotes that
T4327 24175-24181 VBD denotes formed
T4328 24159-24162 DT denotes the
T4329 24170-24174 NNS denotes foci
T4330 24163-24167 NN denotes MLH1
T4331 24167-24168 HYPH denotes /
T4332 24168-24169 CD denotes 3
T4333 24182-24186 RB denotes only
T4334 24187-24189 IN denotes on
T4335 24190-24201 NNS denotes chromosomes
T4336 24202-24206 IN denotes with
T4337 24207-24212 RB denotes fully
T4338 24213-24221 VBN denotes repaired
T4339 24222-24226 NNS denotes DSBs
T4340 24226-24227 . denotes .
T4341 24227-24304 sentence denotes To test this directly, we conducted double staining for MLH1 and RAD51/DMC1.
T4342 24228-24230 TO denotes To
T4343 24231-24235 VB denotes test
T4344 24254-24263 VBD denotes conducted
T4345 24236-24240 DT denotes this
T4346 24241-24249 RB denotes directly
T4347 24249-24251 , denotes ,
T4348 24251-24253 PRP denotes we
T4349 24264-24270 JJ denotes double
T4350 24271-24279 NN denotes staining
T4351 24280-24283 IN denotes for
T4352 24284-24288 NN denotes MLH1
T4353 24289-24292 CC denotes and
T4354 24293-24298 NN denotes RAD51
T4355 24299-24303 NN denotes DMC1
T4356 24298-24299 HYPH denotes /
T4357 24303-24304 . denotes .
T4358 24304-24407 sentence denotes MLH1 foci were present on chromosomes that also contained numerous RAD51/DMC1 foci (Figure 4O and 4P).
T4359 24305-24309 NN denotes MLH1
T4360 24310-24314 NNS denotes foci
T4361 24315-24319 VBD denotes were
T4362 24320-24327 JJ denotes present
T4363 24328-24330 IN denotes on
T4364 24331-24342 NNS denotes chromosomes
T4365 24343-24347 WDT denotes that
T4366 24353-24362 VBD denotes contained
T4367 24348-24352 RB denotes also
T4368 24363-24371 JJ denotes numerous
T4369 24383-24387 NNS denotes foci
T4370 24372-24377 NN denotes RAD51
T4371 24378-24382 NN denotes DMC1
T4372 24377-24378 HYPH denotes /
T4373 24388-24389 -LRB- denotes (
T4374 24396-24398 NN denotes 4O
T4375 24389-24395 NN denotes Figure
T4376 24399-24402 CC denotes and
T4377 24403-24405 NN denotes 4P
T4378 24405-24406 -RRB- denotes )
T4379 24406-24407 . denotes .
T4380 24407-24876 sentence denotes To assess whether these MLH1/3 foci in Trip13Gt/Gt pachytene spermatocytes represent CO events completed to a point where they could maintain interhomolog attachments though the end of prophase I, we treated testicular cells from 17.5–20.5-d-old control (+/+), Trip13Gt/Gt, and Dmc1 −/− mice with the protein phosphatase inhibitor okadaic acid (OA), a chemical that induces degradation of the SC, chromosome condensation, and premature progression to metaphase I [33].
T4381 24408-24410 TO denotes To
T4382 24411-24417 VB denotes assess
T4383 24608-24615 VBD denotes treated
T4384 24418-24425 IN denotes whether
T4385 24483-24492 VBP denotes represent
T4386 24426-24431 DT denotes these
T4387 24439-24443 NNS denotes foci
T4388 24432-24436 NN denotes MLH1
T4389 24436-24437 HYPH denotes /
T4390 24437-24438 CD denotes 3
T4391 24444-24446 IN denotes in
T4392 24447-24455 NN denotes Trip13Gt
T4393 24456-24458 NN denotes Gt
T4394 24455-24456 HYPH denotes /
T4395 24459-24468 NN denotes pachytene
T4396 24469-24482 NNS denotes spermatocytes
T4397 24493-24495 NN denotes CO
T4398 24496-24502 NNS denotes events
T4399 24503-24512 VBN denotes completed
T4400 24513-24515 IN denotes to
T4401 24516-24517 DT denotes a
T4402 24518-24523 NN denotes point
T4403 24524-24529 WRB denotes where
T4404 24541-24549 VB denotes maintain
T4405 24530-24534 PRP denotes they
T4406 24535-24540 MD denotes could
T4407 24550-24562 JJ denotes interhomolog
T4408 24563-24574 NNS denotes attachments
T4409 24575-24581 IN denotes though
T4410 24582-24585 DT denotes the
T4411 24586-24589 NN denotes end
T4412 24590-24592 IN denotes of
T4413 24593-24601 NN denotes prophase
T4414 24602-24603 CD denotes I
T4415 24603-24605 , denotes ,
T4416 24605-24607 PRP denotes we
T4417 24616-24626 JJ denotes testicular
T4418 24627-24632 NNS denotes cells
T4419 24633-24637 IN denotes from
T4420 24638-24642 CD denotes 17.5
T4421 24643-24647 CD denotes 20.5
T4422 24642-24643 SYM denotes –
T4423 24648-24649 NN denotes d
T4424 24647-24648 HYPH denotes -
T4425 24650-24653 JJ denotes old
T4426 24649-24650 HYPH denotes -
T4427 24695-24699 NNS denotes mice
T4428 24654-24661 NN denotes control
T4429 24662-24663 -LRB- denotes (
T4430 24663-24664 SYM denotes +
T4431 24665-24666 SYM denotes +
T4432 24664-24665 HYPH denotes /
T4433 24666-24667 -RRB- denotes )
T4434 24667-24669 , denotes ,
T4435 24669-24677 NN denotes Trip13Gt
T4436 24678-24680 NN denotes Gt
T4437 24677-24678 HYPH denotes /
T4438 24680-24682 , denotes ,
T4439 24682-24685 CC denotes and
T4440 24686-24690 NN denotes Dmc1
T4441 24691-24692 SYM denotes −
T4442 24692-24693 HYPH denotes /
T4443 24693-24694 SYM denotes −
T4444 24700-24704 IN denotes with
T4445 24705-24708 DT denotes the
T4446 24729-24738 NN denotes inhibitor
T4447 24709-24716 NN denotes protein
T4448 24717-24728 NN denotes phosphatase
T4449 24739-24746 JJ denotes okadaic
T4450 24747-24751 NN denotes acid
T4451 24752-24753 -LRB- denotes (
T4452 24753-24755 NN denotes OA
T4453 24755-24756 -RRB- denotes )
T4454 24756-24758 , denotes ,
T4455 24758-24759 DT denotes a
T4456 24760-24768 NN denotes chemical
T4457 24769-24773 WDT denotes that
T4458 24774-24781 VBZ denotes induces
T4459 24782-24793 NN denotes degradation
T4460 24794-24796 IN denotes of
T4461 24797-24800 DT denotes the
T4462 24801-24803 NN denotes SC
T4463 24803-24805 , denotes ,
T4464 24805-24815 NN denotes chromosome
T4465 24816-24828 NN denotes condensation
T4466 24828-24830 , denotes ,
T4467 24830-24833 CC denotes and
T4468 24834-24843 JJ denotes premature
T4469 24844-24855 NN denotes progression
T4470 24856-24858 IN denotes to
T4471 24859-24868 NN denotes metaphase
T4472 24869-24870 CD denotes I
T4473 24871-24872 -LRB- denotes [
T4474 24872-24874 CD denotes 33
T4475 24874-24875 -RRB- denotes ]
T4476 24875-24876 . denotes .
T4477 24876-24937 sentence denotes Fifteen metaphase spreads were identified for each genotype.
T4478 24877-24884 CD denotes Fifteen
T4479 24895-24902 NNS denotes spreads
T4480 24885-24894 NN denotes metaphase
T4481 24908-24918 VBN denotes identified
T4482 24903-24907 VBD denotes were
T4483 24919-24922 IN denotes for
T4484 24923-24927 DT denotes each
T4485 24928-24936 NN denotes genotype
T4486 24936-24937 . denotes .
T4487 24937-25187 sentence denotes Whereas all of the Dmc1 −/− spreads had ∼35 or more condensed chromosomes, all of the +/+ and Trip13Gt/Gt spreads had 20–25, suggesting that the MLH1/3 foci in Trip13Gt/Gt pachytene spermatocytes represent sites of completed, or near-completed, COs.
T4488 24938-24945 IN denotes Whereas
T4489 24974-24977 VBD denotes had
T4490 24946-24949 DT denotes all
T4491 24950-24952 IN denotes of
T4492 24953-24956 DT denotes the
T4493 24966-24973 NNS denotes spreads
T4494 24957-24961 NN denotes Dmc1
T4495 24962-24963 SYM denotes −
T4496 24963-24964 HYPH denotes /
T4497 24964-24965 SYM denotes −
T4498 25052-25055 VBD denotes had
T4499 24978-24979 SYM denotes ∼
T4500 24979-24981 CD denotes 35
T4501 25000-25011 NNS denotes chromosomes
T4502 24982-24984 CC denotes or
T4503 24985-24989 JJR denotes more
T4504 24990-24999 VBN denotes condensed
T4505 25011-25013 , denotes ,
T4506 25013-25016 DT denotes all
T4507 25017-25019 IN denotes of
T4508 25020-25023 DT denotes the
T4509 25044-25051 NNS denotes spreads
T4510 25024-25025 SYM denotes +
T4511 25026-25027 SYM denotes +
T4512 25025-25026 HYPH denotes /
T4513 25028-25031 CC denotes and
T4514 25032-25040 NN denotes Trip13Gt
T4515 25041-25043 NN denotes Gt
T4516 25040-25041 HYPH denotes /
T4517 25056-25058 CD denotes 20
T4518 25059-25061 CD denotes 25
T4519 25058-25059 SYM denotes –
T4520 25061-25063 , denotes ,
T4521 25063-25073 VBG denotes suggesting
T4522 25074-25078 IN denotes that
T4523 25134-25143 VBP denotes represent
T4524 25079-25082 DT denotes the
T4525 25090-25094 NNS denotes foci
T4526 25083-25087 NN denotes MLH1
T4527 25087-25088 HYPH denotes /
T4528 25088-25089 CD denotes 3
T4529 25095-25097 IN denotes in
T4530 25098-25106 NN denotes Trip13Gt
T4531 25107-25109 NN denotes Gt
T4532 25106-25107 HYPH denotes /
T4533 25110-25119 NN denotes pachytene
T4534 25120-25133 NNS denotes spermatocytes
T4535 25144-25149 NNS denotes sites
T4536 25150-25152 IN denotes of
T4537 25153-25162 JJ denotes completed
T4538 25183-25186 NNS denotes COs
T4539 25162-25164 , denotes ,
T4540 25164-25166 CC denotes or
T4541 25167-25171 RB denotes near
T4542 25172-25181 JJ denotes completed
T4543 25171-25172 HYPH denotes -
T4544 25181-25183 , denotes ,
T4545 25186-25187 . denotes .
T4546 25187-25360 sentence denotes Because the preparations were made from whole testes, it is possible that the univalent-containing metaphases from Dmc1 −/− mice were from spermatogonia, not spermatocytes.
T4547 25188-25195 IN denotes Because
T4548 25218-25222 VBN denotes made
T4549 25196-25199 DT denotes the
T4550 25200-25212 NNS denotes preparations
T4551 25213-25217 VBD denotes were
T4552 25245-25247 VBZ denotes is
T4553 25223-25227 IN denotes from
T4554 25228-25233 JJ denotes whole
T4555 25234-25240 NNS denotes testes
T4556 25240-25242 , denotes ,
T4557 25242-25244 PRP denotes it
T4558 25248-25256 JJ denotes possible
T4559 25257-25261 IN denotes that
T4560 25317-25321 VBD denotes were
T4561 25262-25265 DT denotes the
T4562 25287-25297 NNS denotes metaphases
T4563 25266-25275 NN denotes univalent
T4564 25276-25286 VBG denotes containing
T4565 25275-25276 HYPH denotes -
T4566 25298-25302 IN denotes from
T4567 25303-25307 NN denotes Dmc1
T4568 25312-25316 NNS denotes mice
T4569 25308-25309 SYM denotes −
T4570 25309-25310 HYPH denotes /
T4571 25310-25311 SYM denotes −
T4572 25322-25326 IN denotes from
T4573 25327-25340 NNS denotes spermatogonia
T4574 25340-25342 , denotes ,
T4575 25342-25345 CC denotes not
T4576 25346-25359 NNS denotes spermatocytes
T4577 25359-25360 . denotes .
T4919 25362-25368 NN denotes TRIP13
T4920 25369-25379 NN denotes Deficiency
T4921 25389-25398 VB denotes Alleviate
T4922 25380-25384 VBP denotes Does
T4923 25385-25388 RB denotes Not
T4924 25399-25406 JJ denotes Meiotic
T4925 25407-25413 NN denotes Arrest
T4926 25414-25424 NNS denotes Phenotypes
T4927 25425-25427 IN denotes of
T4928 25428-25435 NNS denotes Mutants
T4929 25436-25445 JJ denotes Defective
T4930 25446-25448 IN denotes in
T4931 25449-25457 NN denotes Synapsis
T4932 25457-25614 sentence denotes To determine if TRIP13 deficiency prevents apoptosis triggered by asynapsis as in C. elegans, we analyzed mice that were doubly mutant for Spo11 and Trip13.
T4933 25458-25460 TO denotes To
T4934 25461-25470 VB denotes determine
T4935 25555-25563 VBD denotes analyzed
T4936 25471-25473 IN denotes if
T4937 25492-25500 VBZ denotes prevents
T4938 25474-25480 NN denotes TRIP13
T4939 25481-25491 NN denotes deficiency
T4940 25501-25510 NN denotes apoptosis
T4941 25511-25520 VBN denotes triggered
T4942 25521-25523 IN denotes by
T4943 25524-25533 NN denotes asynapsis
T4944 25534-25536 IN denotes as
T4945 25537-25539 IN denotes in
T4946 25540-25542 NNP denotes C.
T4947 25543-25550 NNP denotes elegans
T4948 25550-25552 , denotes ,
T4949 25552-25554 PRP denotes we
T4950 25564-25568 NNS denotes mice
T4951 25569-25573 WDT denotes that
T4952 25574-25578 VBD denotes were
T4953 25579-25585 RB denotes doubly
T4954 25586-25592 NN denotes mutant
T4955 25593-25596 IN denotes for
T4956 25597-25602 NN denotes Spo11
T4957 25603-25606 CC denotes and
T4958 25607-25613 NN denotes Trip13
T4959 25613-25614 . denotes .
T4960 25614-25761 sentence denotes SPO11 is a transesterase that is essential for the creation of genetically programmed DSB during leptonema of many organisms, including mice [18].
T4961 25615-25620 NN denotes SPO11
T4962 25621-25623 VBZ denotes is
T4963 25624-25625 DT denotes a
T4964 25626-25639 NN denotes transesterase
T4965 25640-25644 WDT denotes that
T4966 25645-25647 VBZ denotes is
T4967 25648-25657 JJ denotes essential
T4968 25658-25661 IN denotes for
T4969 25662-25665 DT denotes the
T4970 25666-25674 NN denotes creation
T4971 25675-25677 IN denotes of
T4972 25678-25689 RB denotes genetically
T4973 25690-25700 VBN denotes programmed
T4974 25701-25704 NN denotes DSB
T4975 25705-25711 IN denotes during
T4976 25712-25721 NN denotes leptonema
T4977 25722-25724 IN denotes of
T4978 25725-25729 JJ denotes many
T4979 25730-25739 NNS denotes organisms
T4980 25739-25741 , denotes ,
T4981 25741-25750 VBG denotes including
T4982 25751-25755 NNS denotes mice
T4983 25756-25757 -LRB- denotes [
T4984 25757-25759 CD denotes 18
T4985 25759-25760 -RRB- denotes ]
T4986 25760-25761 . denotes .
T4987 25761-25883 sentence denotes In C. elegans, spo-11 mutant gametes have extensive asynapsis, which triggers PCH-2 dependent apoptosis in pachynema [2].
T4988 25762-25764 IN denotes In
T4989 25799-25803 VBP denotes have
T4990 25765-25767 NNP denotes C.
T4991 25768-25775 NNP denotes elegans
T4992 25775-25777 , denotes ,
T4993 25777-25780 NN denotes spo
T4994 25791-25798 NNS denotes gametes
T4995 25780-25781 HYPH denotes -
T4996 25781-25783 CD denotes 11
T4997 25784-25790 NN denotes mutant
T4998 25804-25813 JJ denotes extensive
T4999 25814-25823 NN denotes asynapsis
T5000 25823-25825 , denotes ,
T5001 25825-25830 WDT denotes which
T5002 25831-25839 VBZ denotes triggers
T5003 25840-25843 NN denotes PCH
T5004 25846-25855 JJ denotes dependent
T5005 25843-25844 HYPH denotes -
T5006 25844-25845 CD denotes 2
T5007 25856-25865 NN denotes apoptosis
T5008 25866-25868 IN denotes in
T5009 25869-25878 NN denotes pachynema
T5010 25879-25880 -LRB- denotes [
T5011 25880-25881 CD denotes 2
T5012 25881-25882 -RRB- denotes ]
T5013 25882-25883 . denotes .
T5014 25883-26086 sentence denotes In mice, Spo11 −/− spermatocytes are severely defective in homologous chromosome synapsis [34,35], and arrest with chromosomes in a state characteristic of the zygotene/pachytene transition (Figure 3H).
T5015 25884-25886 IN denotes In
T5016 25917-25920 VBP denotes are
T5017 25887-25891 NNS denotes mice
T5018 25891-25893 , denotes ,
T5019 25893-25898 NN denotes Spo11
T5020 25903-25916 NNS denotes spermatocytes
T5021 25899-25900 SYM denotes −
T5022 25900-25901 HYPH denotes /
T5023 25901-25902 SYM denotes −
T5024 25921-25929 RB denotes severely
T5025 25930-25939 JJ denotes defective
T5026 25940-25942 IN denotes in
T5027 25943-25953 JJ denotes homologous
T5028 25965-25973 NN denotes synapsis
T5029 25954-25964 NN denotes chromosome
T5030 25974-25975 -LRB- denotes [
T5031 25978-25980 CD denotes 35
T5032 25975-25977 CD denotes 34
T5033 25977-25978 , denotes ,
T5034 25980-25981 -RRB- denotes ]
T5035 25981-25983 , denotes ,
T5036 25983-25986 CC denotes and
T5037 25987-25993 VBP denotes arrest
T5038 25994-25998 IN denotes with
T5039 25999-26010 NNS denotes chromosomes
T5040 26011-26013 IN denotes in
T5041 26014-26015 DT denotes a
T5042 26016-26021 NN denotes state
T5043 26022-26036 JJ denotes characteristic
T5044 26037-26039 IN denotes of
T5045 26040-26043 DT denotes the
T5046 26063-26073 NN denotes transition
T5047 26044-26052 NN denotes zygotene
T5048 26053-26062 NN denotes pachytene
T5049 26052-26053 HYPH denotes /
T5050 26074-26075 -LRB- denotes (
T5051 26082-26084 NN denotes 3H
T5052 26075-26081 NN denotes Figure
T5053 26084-26085 -RRB- denotes )
T5054 26085-26086 . denotes .
T5055 26086-26284 sentence denotes Spermatocytes in Trip13Gt/Gt Spo11 −/− testes progressed maximally to that point before undergoing death (Figs 3I), well before the spindle checkpoint that eliminates achiasmate spermatocytes [36].
T5056 26087-26100 NNS denotes Spermatocytes
T5057 26133-26143 VBD denotes progressed
T5058 26101-26103 IN denotes in
T5059 26104-26112 NN denotes Trip13Gt
T5060 26113-26115 NN denotes Gt
T5061 26112-26113 HYPH denotes /
T5062 26126-26132 NNS denotes testes
T5063 26116-26121 NN denotes Spo11
T5064 26122-26123 SYM denotes −
T5065 26123-26124 HYPH denotes /
T5066 26124-26125 SYM denotes −
T5067 26144-26153 RB denotes maximally
T5068 26154-26156 IN denotes to
T5069 26157-26161 DT denotes that
T5070 26162-26167 NN denotes point
T5071 26168-26174 IN denotes before
T5072 26175-26185 VBG denotes undergoing
T5073 26186-26191 NN denotes death
T5074 26192-26193 -LRB- denotes (
T5075 26198-26200 NN denotes 3I
T5076 26193-26197 NNS denotes Figs
T5077 26200-26201 -RRB- denotes )
T5078 26201-26203 , denotes ,
T5079 26203-26207 RB denotes well
T5080 26208-26214 IN denotes before
T5081 26215-26218 DT denotes the
T5082 26227-26237 NN denotes checkpoint
T5083 26219-26226 NN denotes spindle
T5084 26238-26242 WDT denotes that
T5085 26243-26253 VBZ denotes eliminates
T5086 26254-26264 NN denotes achiasmate
T5087 26265-26278 NNS denotes spermatocytes
T5088 26279-26280 -LRB- denotes [
T5089 26280-26282 CD denotes 36
T5090 26282-26283 -RRB- denotes ]
T5091 26283-26284 . denotes .
T5092 26284-26434 sentence denotes There was no evidence of metaphase I spermatocytes or postmeiotic spermatids in these testes, unlike those seen in Trip13 single mutants (Figure 3G).
T5093 26285-26290 EX denotes There
T5094 26291-26294 VBD denotes was
T5095 26295-26297 DT denotes no
T5096 26298-26306 NN denotes evidence
T5097 26307-26309 IN denotes of
T5098 26310-26319 NN denotes metaphase
T5099 26322-26335 NNS denotes spermatocytes
T5100 26320-26321 CD denotes I
T5101 26336-26338 CC denotes or
T5102 26339-26350 JJ denotes postmeiotic
T5103 26351-26361 NNS denotes spermatids
T5104 26362-26364 IN denotes in
T5105 26365-26370 DT denotes these
T5106 26371-26377 NNS denotes testes
T5107 26377-26379 , denotes ,
T5108 26379-26385 IN denotes unlike
T5109 26386-26391 DT denotes those
T5110 26392-26396 VBN denotes seen
T5111 26397-26399 IN denotes in
T5112 26400-26406 NN denotes Trip13
T5113 26414-26421 NNS denotes mutants
T5114 26407-26413 JJ denotes single
T5115 26422-26423 -LRB- denotes (
T5116 26430-26432 NN denotes 3G
T5117 26423-26429 NN denotes Figure
T5118 26432-26433 -RRB- denotes )
T5119 26433-26434 . denotes .
T5120 26434-26774 sentence denotes In contrast to the complete synapsis in Trip13Gt/Gt pachytene spermatocytes (Figure 5A), in which SPO11 is available in leptonema to initiate (via DSB induction, Figure S2A and S2B) a recombination-driven homolog search, chromosome synapsis in doubly mutant spermatocytes was highly disrupted as in Spo11 single mutants (Figure 5B and 5C).
T5121 26435-26437 IN denotes In
T5122 26718-26727 VBN denotes disrupted
T5123 26438-26446 NN denotes contrast
T5124 26447-26449 IN denotes to
T5125 26450-26453 DT denotes the
T5126 26463-26471 NN denotes synapsis
T5127 26454-26462 JJ denotes complete
T5128 26472-26474 IN denotes in
T5129 26475-26483 NN denotes Trip13Gt
T5130 26484-26486 NN denotes Gt
T5131 26483-26484 HYPH denotes /
T5132 26487-26496 NN denotes pachytene
T5133 26497-26510 NNS denotes spermatocytes
T5134 26511-26512 -LRB- denotes (
T5135 26519-26521 NN denotes 5A
T5136 26512-26518 NN denotes Figure
T5137 26521-26522 -RRB- denotes )
T5138 26522-26524 , denotes ,
T5139 26524-26526 IN denotes in
T5140 26539-26541 VBZ denotes is
T5141 26527-26532 WDT denotes which
T5142 26533-26538 NN denotes SPO11
T5143 26542-26551 JJ denotes available
T5144 26552-26554 IN denotes in
T5145 26555-26564 NN denotes leptonema
T5146 26565-26567 TO denotes to
T5147 26568-26576 VB denotes initiate
T5148 26577-26578 -LRB- denotes (
T5149 26604-26607 NN denotes S2A
T5150 26578-26581 IN denotes via
T5151 26582-26585 NN denotes DSB
T5152 26586-26595 NN denotes induction
T5153 26595-26597 , denotes ,
T5154 26597-26603 NN denotes Figure
T5155 26608-26611 CC denotes and
T5156 26612-26615 NN denotes S2B
T5157 26615-26616 -RRB- denotes )
T5158 26617-26618 DT denotes a
T5159 26648-26654 NN denotes search
T5160 26619-26632 NN denotes recombination
T5161 26633-26639 VBN denotes driven
T5162 26632-26633 HYPH denotes -
T5163 26640-26647 NN denotes homolog
T5164 26654-26656 , denotes ,
T5165 26656-26666 NN denotes chromosome
T5166 26667-26675 NN denotes synapsis
T5167 26676-26678 IN denotes in
T5168 26679-26685 RB denotes doubly
T5169 26686-26692 JJ denotes mutant
T5170 26693-26706 NNS denotes spermatocytes
T5171 26707-26710 VBD denotes was
T5172 26711-26717 RB denotes highly
T5173 26728-26730 IN denotes as
T5174 26731-26733 IN denotes in
T5175 26734-26739 NN denotes Spo11
T5176 26747-26754 NNS denotes mutants
T5177 26740-26746 JJ denotes single
T5178 26755-26756 -LRB- denotes (
T5179 26763-26765 NN denotes 5B
T5180 26756-26762 NN denotes Figure
T5181 26766-26769 CC denotes and
T5182 26770-26772 NN denotes 5C
T5183 26772-26773 -RRB- denotes )
T5184 26773-26774 . denotes .
T5185 26774-26993 sentence denotes Identical studies were performed with mice deficient for Mei1, a vertebrate-specific gene also required for DSB formation and chromosome synapsis [37], with similar results (Figure 3J and 3K; immunocytology not shown).
T5186 26775-26784 JJ denotes Identical
T5187 26785-26792 NNS denotes studies
T5188 26798-26807 VBN denotes performed
T5189 26793-26797 VBD denotes were
T5190 26808-26812 IN denotes with
T5191 26813-26817 NNS denotes mice
T5192 26818-26827 JJ denotes deficient
T5235 27322-27323 IN denotes t
T5236 27323-27327 sentence denotes , de
T5237 27323-27325 , denotes ,
T5238 27325-27326 JJ denotes d
T5239 27326-27327 NNS denotes e
T5240 27327-27335 sentence denotes letion o
T5241 27327-27329 JJR denotes le
T5242 27329-27333 NN denotes tion
T5243 27334-27335 TO denotes o
T5244 27335-27420 sentence denotes f PCH2 alleviates the pachytene arrest caused by asynaptic mutants zip1 and zip2 [8].
T5245 27342-27352 VBZ denotes alleviates
T5246 27335-27336 IN denotes f
T5247 27337-27341 NN denotes PCH2
T5248 27353-27356 DT denotes the
T5249 27367-27373 NN denotes arrest
T5250 27357-27366 NN denotes pachytene
T5251 27374-27380 VBN denotes caused
T5252 27381-27383 IN denotes by
T5253 27384-27393 JJ denotes asynaptic
T5254 27402-27406 NN denotes zip1
T5255 27394-27401 NNS denotes mutants
T5256 27407-27410 CC denotes and
T5257 27411-27415 NN denotes zip2
T5258 27416-27417 -LRB- denotes [
T5259 27417-27418 CD denotes 8
T5260 27418-27419 -RRB- denotes ]
T5261 27419-27420 . denotes .
T5262 27420-27639 sentence denotes Although mouse SYCP1 might be a functional equivalent of Zip1p, because Sycp1 mutant spermatocytes arrest at approximately the same point as Trip13 mutants, there would be no opportunity to observe bypass of Sycp1 −/−.
T5263 27421-27429 IN denotes Although
T5264 27448-27450 VB denotes be
T5265 27430-27435 NN denotes mouse
T5266 27436-27441 NN denotes SYCP1
T5267 27442-27447 MD denotes might
T5268 27590-27592 VB denotes be
T5269 27451-27452 DT denotes a
T5270 27464-27474 NN denotes equivalent
T5271 27453-27463 JJ denotes functional
T5272 27475-27477 IN denotes of
T5273 27478-27483 NN denotes Zip1p
T5274 27483-27485 , denotes ,
T5275 27485-27492 IN denotes because
T5276 27520-27526 VBP denotes arrest
T5277 27493-27498 NN denotes Sycp1
T5278 27506-27519 NNS denotes spermatocytes
T5279 27499-27505 NN denotes mutant
T5280 27527-27529 IN denotes at
T5281 27530-27543 RB denotes approximately
T5282 27553-27558 NN denotes point
T5283 27544-27547 DT denotes the
T5284 27548-27552 JJ denotes same
T5285 27559-27561 IN denotes as
T5286 27562-27568 NN denotes Trip13
T5287 27569-27576 NNS denotes mutants
T5288 27576-27578 , denotes ,
T5289 27578-27583 EX denotes there
T5290 27584-27589 MD denotes would
T5291 27593-27595 DT denotes no
T5292 27596-27607 NN denotes opportunity
T5293 27608-27610 TO denotes to
T5294 27611-27618 VB denotes observe
T5295 27619-27625 NN denotes bypass
T5296 27626-27628 IN denotes of
T5297 27629-27634 NN denotes Sycp1
T5298 27635-27636 SYM denotes −
T5299 27636-27637 HYPH denotes /
T5300 27637-27638 SYM denotes −
T5301 27638-27639 . denotes .
T5302 27639-27798 sentence denotes Since Zip2p is present at sites of axial associations, even in zip1 mutants, it has been suggested that Zip2p promotes initiation of chromosome synapsis [38].
T5303 27640-27645 IN denotes Since
T5304 27652-27654 VBZ denotes is
T5305 27646-27651 NN denotes Zip2p
T5306 27729-27738 VBN denotes suggested
T5307 27655-27662 JJ denotes present
T5308 27663-27665 IN denotes at
T5309 27666-27671 NNS denotes sites
T5310 27672-27674 IN denotes of
T5311 27675-27680 JJ denotes axial
T5312 27681-27693 NNS denotes associations
T5313 27693-27695 , denotes ,
T5314 27695-27699 RB denotes even
T5315 27700-27702 IN denotes in
T5316 27703-27707 NN denotes zip1
T5317 27708-27715 NNS denotes mutants
T5318 27715-27717 , denotes ,
T5319 27717-27719 PRP denotes it
T5320 27720-27723 VBZ denotes has
T5321 27724-27728 VBN denotes been
T5322 27739-27743 IN denotes that
T5323 27750-27758 VBZ denotes promotes
T5324 27744-27749 NN denotes Zip2p
T5325 27759-27769 NN denotes initiation
T5326 27770-27772 IN denotes of
T5327 27773-27783 NN denotes chromosome
T5328 27784-27792 NN denotes synapsis
T5329 27793-27794 -LRB- denotes [
T5330 27794-27796 CD denotes 38
T5331 27796-27797 -RRB- denotes ]
T5332 27797-27798 . denotes .
T5333 27798-27920 sentence denotes These observations raise the possibility that in yeast, Pch2p responds to synapsis polymerization rather than initiation.
T5334 27799-27804 DT denotes These
T5335 27805-27817 NNS denotes observations
T5336 27818-27823 VBP denotes raise
T5337 27824-27827 DT denotes the
T5338 27828-27839 NN denotes possibility
T5339 27840-27844 IN denotes that
T5340 27861-27869 VBZ denotes responds
T5341 27845-27847 IN denotes in
T5342 27848-27853 NN denotes yeast
T5343 27853-27855 , denotes ,
T5344 27855-27860 NN denotes Pch2p
T5345 27870-27872 IN denotes to
T5346 27873-27881 NN denotes synapsis
T5347 27882-27896 NN denotes polymerization
T5348 27897-27903 RB denotes rather
T5349 27904-27908 IN denotes than
T5350 27909-27919 NN denotes initiation
T5351 27919-27920 . denotes .
T5352 27920-28020 sentence denotes To test this, we performed epistasis analysis with a Rec8 allele (Rec8Mei8, abbreviated as Rec8 −).
T5353 27921-27923 TO denotes To
T5354 27924-27928 VB denotes test
T5355 27938-27947 VBD denotes performed
T5356 27929-27933 DT denotes this
T5357 27933-27935 , denotes ,
T5358 27935-27937 PRP denotes we
T5359 27948-27957 NN denotes epistasis
T5360 27958-27966 NN denotes analysis
T5361 27967-27971 IN denotes with
T5362 27972-27973 DT denotes a
T5363 27979-27985 NN denotes allele
T5364 27974-27978 NN denotes Rec8
T5365 27986-27987 -LRB- denotes (
T5366 27987-27995 NN denotes Rec8Mei8
T5367 27995-27997 , denotes ,
T5368 27997-28008 VBN denotes abbreviated
T5369 28009-28011 IN denotes as
T5370 28012-28016 NN denotes Rec8
T5371 28017-28018 SYM denotes −
T5372 28018-28019 -RRB- denotes )
T5373 28019-28020 . denotes .
T5374 28020-28224 sentence denotes Meiotic chromosomes of Rec8 mutant spermatocytes undergo apparent homolog pairing and interhomolog synaptic initiation, but are defective in DSB repair and fail to maintain interhomolog synapsis [39,40].
T5375 28021-28028 JJ denotes Meiotic
T5376 28029-28040 NNS denotes chromosomes
T5377 28070-28077 VBP denotes undergo
T5378 28041-28043 IN denotes of
T5379 28044-28048 NN denotes Rec8
T5380 28056-28069 NNS denotes spermatocytes
T5381 28049-28055 NN denotes mutant
T5382 28078-28086 JJ denotes apparent
T5383 28095-28102 NN denotes pairing
T5384 28087-28094 NN denotes homolog
T5385 28103-28106 CC denotes and
T5386 28107-28119 JJ denotes interhomolog
T5387 28129-28139 NN denotes initiation
T5388 28120-28128 JJ denotes synaptic
T5389 28139-28141 , denotes ,
T5390 28141-28144 CC denotes but
T5391 28145-28148 VBP denotes are
T5392 28149-28158 JJ denotes defective
T5393 28159-28161 IN denotes in
T5394 28162-28165 NN denotes DSB
T5395 28166-28172 NN denotes repair
T5396 28173-28176 CC denotes and
T5397 28177-28181 VBP denotes fail
T5398 28182-28184 TO denotes to
T5399 28185-28193 VB denotes maintain
T5400 28194-28206 JJ denotes interhomolog
T5401 28207-28215 NN denotes synapsis
T5402 28216-28217 -LRB- denotes [
T5403 28220-28222 CD denotes 40
T5404 28217-28219 CD denotes 39
T5405 28219-28220 , denotes ,
T5406 28222-28223 -RRB- denotes ]
T5407 28223-28224 . denotes .
T5408 28224-28309 sentence denotes Rather, sister chromatids appear to synapse and are bound by SYCP1 along their axes.
T5409 28225-28231 RB denotes Rather
T5410 28251-28257 VBP denotes appear
T5411 28231-28233 , denotes ,
T5412 28233-28239 NN denotes sister
T5413 28240-28250 NNS denotes chromatids
T5414 28258-28260 TO denotes to
T5415 28261-28268 VB denotes synapse
T5416 28269-28272 CC denotes and
T5417 28273-28276 VBP denotes are
T5418 28277-28282 VBN denotes bound
T5419 28283-28285 IN denotes by
T5420 28286-28291 NN denotes SYCP1
T5421 28292-28297 IN denotes along
T5422 28298-28303 PRP$ denotes their
T5423 28304-28308 NNS denotes axes
T5424 28308-28309 . denotes .
T5425 28309-28367 sentence denotes Rec8 mutants do not progress to diplonema or metaphase I.
T5426 28310-28314 NN denotes Rec8
T5427 28315-28322 NNS denotes mutants
T5428 28330-28338 VB denotes progress
T5429 28323-28325 VBP denotes do
T5430 28326-28329 RB denotes not
T5431 28339-28341 IN denotes to
T5432 28342-28351 NN denotes diplonema
T5433 28352-28354 CC denotes or
T5434 28355-28364 NN denotes metaphase
T5435 28365-28366 CD denotes I
T5436 28366-28367 . denotes .
T5437 28367-28434 sentence denotes Double mutant analysis indicated that Rec8 is epistatic to Trip13.
T5438 28368-28374 JJ denotes Double
T5439 28382-28390 NN denotes analysis
T5440 28375-28381 NN denotes mutant
T5441 28391-28400 VBD denotes indicated
T5442 28401-28405 IN denotes that
T5443 28411-28413 VBZ denotes is
T5444 28406-28410 NN denotes Rec8
T5445 28414-28423 JJ denotes epistatic
T5446 28424-28426 IN denotes to
T5447 28427-28433 NN denotes Trip13
T5448 28433-28434 . denotes .
T5449 28434-28653 sentence denotes As in the Spo11 and Mei1 experiments, histology of testes deficient for both REC8 and TRIP13 resembled the Rec8 mutant, with no evidence of progression to metaphase I that occurs in Trip13Gt/Gt mice (Figure 3L and 3M).
T5450 28435-28437 IN denotes As
T5451 28528-28537 VBD denotes resembled
T5452 28438-28440 IN denotes in
T5453 28441-28444 DT denotes the
T5454 28460-28471 NNS denotes experiments
T5455 28445-28450 NN denotes Spo11
T5456 28451-28454 CC denotes and
T5457 28455-28459 NN denotes Mei1
T5458 28471-28473 , denotes ,
T5459 28473-28482 NN denotes histology
T5460 28483-28485 IN denotes of
T5461 28486-28492 NNS denotes testes
T5462 28493-28502 JJ denotes deficient
T5463 28503-28506 IN denotes for
T5464 28507-28511 CC denotes both
T5465 28512-28516 NN denotes REC8
T5466 28517-28520 CC denotes and
T5467 28521-28527 NN denotes TRIP13
T5468 28538-28541 DT denotes the
T5469 28547-28553 NN denotes mutant
T5470 28542-28546 NN denotes Rec8
T5471 28553-28555 , denotes ,
T5472 28555-28559 IN denotes with
T5473 28560-28562 DT denotes no
T5474 28563-28571 NN denotes evidence
T5475 28572-28574 IN denotes of
T5476 28575-28586 NN denotes progression
T5477 28587-28589 IN denotes to
T5478 28590-28599 NN denotes metaphase
T5479 28600-28601 CD denotes I
T5480 28602-28606 WDT denotes that
T5481 28607-28613 VBZ denotes occurs
T5482 28614-28616 IN denotes in
T5483 28617-28625 NN denotes Trip13Gt
T5484 28626-28628 NN denotes Gt
T5485 28625-28626 HYPH denotes /
T5486 28629-28633 NNS denotes mice
T5487 28634-28635 -LRB- denotes (
T5488 28642-28644 NN denotes 3L
T5489 28635-28641 NN denotes Figure
T5490 28645-28648 CC denotes and
T5491 28649-28651 NN denotes 3M
T5492 28651-28652 -RRB- denotes )
T5493 28652-28653 . denotes .
T5494 28653-28882 sentence denotes Immunocytological analysis of spread chromosomes showed a failure of homologous chromosome synapsis in both the Rec8 −/− and Rec8 −/− Trip13Gt/Gt spermatocytes, as previously reported for Rec8 mutants (Figure 5D and 5E) [39,40].
T5495 28654-28671 JJ denotes Immunocytological
T5496 28672-28680 NN denotes analysis
T5497 28703-28709 VBD denotes showed
T5498 28681-28683 IN denotes of
T5499 28684-28690 NN denotes spread
T5500 28691-28702 NNS denotes chromosomes
T5501 28710-28711 DT denotes a
T5502 28712-28719 NN denotes failure
T5503 28720-28722 IN denotes of
T5504 28723-28733 JJ denotes homologous
T5505 28745-28753 NN denotes synapsis
T5506 28734-28744 NN denotes chromosome
T5507 28754-28756 IN denotes in
T5508 28757-28761 CC denotes both
T5509 28800-28813 NNS denotes spermatocytes
T5510 28762-28765 DT denotes the
T5511 28766-28770 NN denotes Rec8
T5512 28771-28772 SYM denotes −
T5513 28772-28773 HYPH denotes /
T5514 28773-28774 SYM denotes −
T5515 28775-28778 CC denotes and
T5516 28779-28783 NN denotes Rec8
T5517 28797-28799 NN denotes Gt
T5518 28784-28785 SYM denotes −
T5519 28785-28786 HYPH denotes /
T5520 28786-28787 SYM denotes −
T5521 28788-28796 NN denotes Trip13Gt
T5522 28796-28797 HYPH denotes /
T5523 28813-28815 , denotes ,
T5524 28815-28817 IN denotes as
T5525 28829-28837 VBN denotes reported
T5526 28818-28828 RB denotes previously
T5527 28838-28841 IN denotes for
T5528 28842-28846 NN denotes Rec8
T5529 28847-28854 NNS denotes mutants
T5530 28855-28856 -LRB- denotes (
T5531 28863-28865 NN denotes 5D
T5532 28856-28862 NN denotes Figure
T5533 28866-28869 CC denotes and
T5534 28870-28872 NN denotes 5E
T5535 28872-28873 -RRB- denotes )
T5536 28874-28875 -LRB- denotes [
T5537 28878-28880 CD denotes 40
T5538 28875-28877 CD denotes 39
T5539 28877-28878 , denotes ,
T5540 28880-28881 -RRB- denotes ]
T5541 28881-28882 . denotes .
T5542 28882-29085 sentence denotes Although subsequent reports indicate otherwise [10,12], deletion of PCH2 in yeast was originally reported to alleviate meiotic arrest caused by deficiency for the meiosis-specific RecA homolog DMC1 [8].
T5543 28883-28891 IN denotes Although
T5544 28911-28919 VBP denotes indicate
T5545 28892-28902 JJ denotes subsequent
T5546 28903-28910 NNS denotes reports
T5547 28980-28988 VBN denotes reported
T5548 28920-28929 RB denotes otherwise
T5549 28930-28931 -LRB- denotes [
T5550 28934-28936 CD denotes 12
T5551 28931-28933 CD denotes 10
T5552 28933-28934 , denotes ,
T5553 28936-28937 -RRB- denotes ]
T5554 28937-28939 , denotes ,
T5555 28939-28947 NN denotes deletion
T5556 28948-28950 IN denotes of
T5557 28951-28955 NN denotes PCH2
T5558 28956-28958 IN denotes in
T5559 28959-28964 NN denotes yeast
T5560 28965-28968 VBD denotes was
T5561 28969-28979 RB denotes originally
T5562 28989-28991 TO denotes to
T5563 28992-29001 VB denotes alleviate
T5564 29002-29009 JJ denotes meiotic
T5565 29010-29016 NN denotes arrest
T5566 29017-29023 VBN denotes caused
T5567 29024-29026 IN denotes by
T5568 29027-29037 NN denotes deficiency
T5569 29038-29041 IN denotes for
T5570 29042-29045 DT denotes the
T5571 29068-29075 NN denotes homolog
T5572 29046-29053 NN denotes meiosis
T5573 29054-29062 JJ denotes specific
T5574 29053-29054 HYPH denotes -
T5575 29063-29067 NN denotes RecA
T5576 29076-29080 NN denotes DMC1
T5577 29081-29082 -LRB- denotes [
T5578 29082-29083 CD denotes 8
T5579 29083-29084 -RRB- denotes ]
T5580 29084-29085 . denotes .
T5581 29085-29185 sentence denotes To investigate this relationship in mice, we constructed animals doubly mutant for Trip13 and Dmc1.
T5582 29086-29088 TO denotes To
T5583 29089-29100 VB denotes investigate
T5584 29131-29142 VBD denotes constructed
T5585 29101-29105 DT denotes this
T5586 29106-29118 NN denotes relationship
T5587 29119-29121 IN denotes in
T5588 29122-29126 NNS denotes mice
T5589 29126-29128 , denotes ,
T5590 29128-29130 PRP denotes we
T5591 29143-29150 NNS denotes animals
T5592 29151-29157 RB denotes doubly
T5593 29158-29164 JJ denotes mutant
T5594 29165-29168 IN denotes for
T5595 29169-29175 NN denotes Trip13
T5596 29176-29179 CC denotes and
T5597 29180-29184 NN denotes Dmc1
T5598 29184-29185 . denotes .
T5599 29185-29488 sentence denotes As in Dmc1 −/− mice, in which spermatocytes undergo meiotic arrest from defective DSB repair and failed chromosome synapsis [16], spermatogenesis in Dmc1 −/− Trip13Gt/Gt testes was uniformly arrested at the point where spermatocytes contained chromatin characteristic of zygonema/pachynema (Figure 3N).
T5600 29186-29188 IN denotes As
T5601 29377-29385 VBN denotes arrested
T5602 29189-29191 IN denotes in
T5603 29192-29196 NN denotes Dmc1
T5604 29201-29205 NNS denotes mice
T5605 29197-29198 SYM denotes −
T5606 29198-29199 HYPH denotes /
T5607 29199-29200 SYM denotes −
T5608 29205-29207 , denotes ,
T5609 29207-29209 IN denotes in
T5610 29230-29237 VBP denotes undergo
T5611 29210-29215 WDT denotes which
T5612 29216-29229 NNS denotes spermatocytes
T5613 29238-29245 JJ denotes meiotic
T5614 29246-29252 NN denotes arrest
T5615 29253-29257 IN denotes from
T5616 29258-29267 JJ denotes defective
T5617 29272-29278 NN denotes repair
T5618 29268-29271 NN denotes DSB
T5619 29279-29282 CC denotes and
T5620 29283-29289 VBN denotes failed
T5621 29301-29309 NN denotes synapsis
T5622 29290-29300 NN denotes chromosome
T5623 29310-29311 -LRB- denotes [
T5624 29311-29313 CD denotes 16
T5625 29313-29314 -RRB- denotes ]
T5626 29314-29316 , denotes ,
T5627 29316-29331 NN denotes spermatogenesis
T5628 29332-29334 IN denotes in
T5629 29335-29339 NN denotes Dmc1
T5630 29356-29362 NNS denotes testes
T5631 29340-29341 SYM denotes −
T5632 29341-29342 HYPH denotes /
T5633 29342-29343 SYM denotes −
T5634 29344-29352 NN denotes Trip13Gt
T5635 29353-29355 NN denotes Gt
T5636 29352-29353 HYPH denotes /
T5637 29363-29366 VBD denotes was
T5638 29367-29376 RB denotes uniformly
T5639 29386-29388 IN denotes at
T5640 29389-29392 DT denotes the
T5641 29393-29398 NN denotes point
T5642 29399-29404 WRB denotes where
T5643 29419-29428 VBD denotes contained
T5644 29405-29418 NNS denotes spermatocytes
T5645 29429-29438 NN denotes chromatin
T5646 29439-29453 JJ denotes characteristic
T5647 29454-29456 IN denotes of
T5648 29457-29465 NN denotes zygonema
T5649 29466-29475 NN denotes pachynema
T5650 29465-29466 HYPH denotes /
T5651 29476-29477 -LRB- denotes (
T5652 29484-29486 NN denotes 3N
T5653 29477-29483 NN denotes Figure
T5654 29486-29487 -RRB- denotes )
T5655 29487-29488 . denotes .
T5656 29488-29788 sentence denotes Immunocytological analysis indicated that both Dmc1 −/− and Dmc1 −/− Trip13Gt/Gt chromosomes had extensive asynapsis compared to Trip13Gt single mutants (Figure 5F–5H), and all had persistent RAD51/DMC1 foci and phosphorylated H2AX (γH2AX; Figure 5I–5L), confirming that Dmc1 is epistatic to Trip13.
T5657 29489-29506 JJ denotes Immunocytological
T5658 29507-29515 NN denotes analysis
T5659 29516-29525 VBD denotes indicated
T5660 29526-29530 IN denotes that
T5661 29582-29585 VBD denotes had
T5662 29531-29535 CC denotes both
T5663 29536-29540 NN denotes Dmc1
T5664 29570-29581 NNS denotes chromosomes
T5665 29541-29542 SYM denotes −
T5666 29542-29543 HYPH denotes /
T5667 29543-29544 SYM denotes −
T5668 29545-29548 CC denotes and
T5669 29549-29553 NN denotes Dmc1
T5670 29567-29569 NN denotes Gt
T5671 29554-29555 SYM denotes −
T5672 29555-29556 HYPH denotes /
T5673 29556-29557 SYM denotes −
T5674 29558-29566 NN denotes Trip13Gt
T5675 29566-29567 HYPH denotes /
T5676 29586-29595 JJ denotes extensive
T5677 29596-29605 NN denotes asynapsis
T5678 29606-29614 VBN denotes compared
T5679 29615-29617 IN denotes to
T5680 29618-29626 NN denotes Trip13Gt
T5681 29634-29641 NNS denotes mutants
T5682 29627-29633 JJ denotes single
T5683 29642-29643 -LRB- denotes (
T5684 29653-29655 NN denotes 5H
T5685 29643-29649 NN denotes Figure
T5686 29650-29652 NN denotes 5F
T5687 29652-29653 SYM denotes –
T5688 29655-29656 -RRB- denotes )
T5689 29656-29658 , denotes ,
T5690 29658-29661 CC denotes and
T5691 29662-29665 DT denotes all
T5692 29666-29669 VBD denotes had
T5693 29670-29680 JJ denotes persistent
T5694 29692-29696 NNS denotes foci
T5695 29681-29686 NN denotes RAD51
T5696 29687-29691 NN denotes DMC1
T5697 29686-29687 HYPH denotes /
T5698 29697-29700 CC denotes and
T5699 29701-29715 VBN denotes phosphorylated
T5700 29716-29720 NN denotes H2AX
T5701 29721-29722 -LRB- denotes (
T5702 29739-29741 NN denotes 5L
T5703 29722-29727 NN denotes γH2AX
T5704 29727-29728 : denotes ;
T5705 29729-29735 NN denotes Figure
T5706 29736-29738 NN denotes 5I
T5707 29738-29739 SYM denotes –
T5708 29741-29742 -RRB- denotes )
T5709 29742-29744 , denotes ,
T5710 29744-29754 VBG denotes confirming
T5711 29755-29759 IN denotes that
T5712 29765-29767 VBZ denotes is
T5713 29760-29764 NN denotes Dmc1
T5714 29768-29777 JJ denotes epistatic
T5715 29778-29780 IN denotes to
T5716 29781-29787 NN denotes Trip13
T5717 29787-29788 . denotes .
T5718 29788-29905 sentence denotes Doubly mutant females had residual ovaries, phenocopying Dmc1 −/− and Trip13Gt/Gt single mutants (unpublished data).
T5719 29789-29795 RB denotes Doubly
T5720 29796-29802 JJ denotes mutant
T5721 29803-29810 NNS denotes females
T5722 29811-29814 VBD denotes had
T5723 29815-29823 JJ denotes residual
T5724 29824-29831 NNS denotes ovaries
T5725 29831-29833 , denotes ,
T5726 29833-29845 VBG denotes phenocopying
T5727 29846-29850 NN denotes Dmc1
T5728 29878-29885 NNS denotes mutants
T5729 29851-29852 SYM denotes −
T5730 29852-29853 HYPH denotes /
T5731 29853-29854 SYM denotes −
T5732 29855-29858 CC denotes and
T5733 29859-29867 NN denotes Trip13Gt
T5734 29868-29870 NN denotes Gt
T5735 29867-29868 HYPH denotes /
T5736 29871-29877 JJ denotes single
T5737 29886-29887 -LRB- denotes (
T5738 29899-29903 NNS denotes data
T5739 29887-29898 JJ denotes unpublished
T5740 29903-29904 -RRB- denotes )
T5741 29904-29905 . denotes .
T5807 29907-29914 JJ denotes Meiotic
T5808 29915-29922 NNS denotes Defects
T5809 29946-29949 VBP denotes Are
T5810 29923-29925 IN denotes in
T5811 29926-29934 NN denotes Trip13Gt
T5812 29935-29937 NN denotes Gt
T5813 29934-29935 HYPH denotes /
T5814 29938-29945 NNS denotes Oocytes
T5815 29950-29953 NN denotes DSB
T5816 29954-29963 JJ denotes Dependent
T5817 29953-29954 HYPH denotes -
T5818 29963-30063 sentence denotes Epistasis analysis of females was insightful with respect to the cause of arrest in Trip13 mutants.
T5819 29964-29973 NN denotes Epistasis
T5820 29974-29982 NN denotes analysis
T5821 29994-29997 VBD denotes was
T5822 29983-29985 IN denotes of
T5823 29986-29993 NNS denotes females
T5824 29998-30008 JJ denotes insightful
T5825 30009-30013 IN denotes with
T5826 30014-30021 NN denotes respect
T5827 30022-30024 IN denotes to
T5828 30025-30028 DT denotes the
T5829 30029-30034 NN denotes cause
T5830 30035-30037 IN denotes of
T5831 30038-30044 NN denotes arrest
T5832 30045-30047 IN denotes in
T5833 30048-30054 NN denotes Trip13
T5834 30055-30062 NNS denotes mutants
T5835 30062-30063 . denotes .
T5836 30063-30219 sentence denotes Both Mei1 −/−/Trip13Gt/Gt and Spo11 −/−/Trip13Gt/Gt females had ovaries with numerous follicles, identical to Mei1 and Spo11 single mutants (Figure 3O–3R).
T5837 30064-30068 CC denotes Both
T5838 30087-30089 NN denotes Gt
T5839 30069-30073 NN denotes Mei1
T5840 30074-30075 SYM denotes −
T5841 30075-30076 HYPH denotes /
T5842 30076-30077 SYM denotes −
T5843 30077-30078 HYPH denotes /
T5844 30078-30086 NN denotes Trip13Gt
T5845 30086-30087 HYPH denotes /
T5846 30124-30127 VBD denotes had
T5847 30090-30093 CC denotes and
T5848 30094-30099 NN denotes Spo11
T5849 30113-30115 NN denotes Gt
T5850 30100-30101 SYM denotes −
T5851 30101-30102 HYPH denotes /
T5852 30102-30103 SYM denotes −
T5853 30103-30104 HYPH denotes /
T5854 30104-30112 NN denotes Trip13Gt
T5855 30112-30113 HYPH denotes /
T5856 30116-30123 NNS denotes females
T5857 30128-30135 NNS denotes ovaries
T5858 30136-30140 IN denotes with
T5859 30141-30149 JJ denotes numerous
T5860 30150-30159 NNS denotes follicles
T5861 30159-30161 , denotes ,
T5862 30161-30170 JJ denotes identical
T5863 30171-30173 IN denotes to
T5864 30174-30178 NN denotes Mei1
T5865 30196-30203 NNS denotes mutants
T5866 30179-30182 CC denotes and
T5867 30183-30188 NN denotes Spo11
T5868 30189-30195 JJ denotes single
T5869 30204-30205 -LRB- denotes (
T5870 30215-30217 NN denotes 3R
T5871 30205-30211 NN denotes Figure
T5872 30212-30214 NN denotes 3O
T5873 30214-30215 SYM denotes –
T5874 30217-30218 -RRB- denotes )
T5875 30218-30219 . denotes .
T5876 30219-30312 sentence denotes Thus, Spo11 and Mei1 are epistatic to Trip13 in oogenesis, just as they are to Dmc1 [13,41].
T5877 30220-30224 RB denotes Thus
T5878 30241-30244 VBP denotes are
T5879 30224-30226 , denotes ,
T5880 30226-30231 NN denotes Spo11
T5881 30232-30235 CC denotes and
T5882 30236-30240 NN denotes Mei1
T5883 30245-30254 JJ denotes epistatic
T5884 30255-30257 IN denotes to
T5885 30258-30264 NN denotes Trip13
T5886 30265-30267 IN denotes in
T5887 30268-30277 NN denotes oogenesis
T5888 30277-30279 , denotes ,
T5889 30279-30283 RB denotes just
T5890 30292-30295 VBP denotes are
T5891 30284-30286 IN denotes as
T5892 30287-30291 PRP denotes they
T5893 30296-30298 IN denotes to
T5894 30299-30303 NN denotes Dmc1
T5895 30304-30305 -LRB- denotes [
T5896 30308-30310 CD denotes 41
T5897 30305-30307 CD denotes 13
T5898 30307-30308 , denotes ,
T5899 30310-30311 -RRB- denotes ]
T5900 30311-30312 . denotes .
T5901 30312-30401 sentence denotes This demonstrates that oocyte loss in Trip13Gt/Gt females is dependent on DSB formation.
T5902 30313-30317 DT denotes This
T5903 30318-30330 VBZ denotes demonstrates
T5904 30331-30335 IN denotes that
T5905 30371-30373 VBZ denotes is
T5906 30336-30342 NN denotes oocyte
T5907 30343-30347 NN denotes loss
T5908 30348-30350 IN denotes in
T5909 30351-30359 NN denotes Trip13Gt
T5910 30360-30362 NN denotes Gt
T5911 30359-30360 HYPH denotes /
T5912 30363-30370 NNS denotes females
T5913 30374-30383 JJ denotes dependent
T5914 30384-30386 IN denotes on
T5915 30387-30390 NN denotes DSB
T5916 30391-30400 NN denotes formation
T5917 30400-30401 . denotes .
T5918 30401-30561 sentence denotes In conjunction with the immunohistochemical data, these data provide strong evidence that meiotic arrest in Trip13 mutant mice is due to defects in DSB repair.
T5919 30402-30404 IN denotes In
T5920 30463-30470 VBP denotes provide
T5921 30405-30416 NN denotes conjunction
T5922 30417-30421 IN denotes with
T5923 30422-30425 DT denotes the
T5924 30446-30450 NNS denotes data
T5925 30426-30445 JJ denotes immunohistochemical
T5926 30450-30452 , denotes ,
T5927 30452-30457 DT denotes these
T5928 30458-30462 NNS denotes data
T5929 30471-30477 JJ denotes strong
T5930 30478-30486 NN denotes evidence
T5931 30487-30491 IN denotes that
T5932 30529-30531 VBZ denotes is
T5933 30492-30499 JJ denotes meiotic
T5934 30500-30506 NN denotes arrest
T5935 30507-30509 IN denotes in
T5936 30510-30516 NN denotes Trip13
T5937 30524-30528 NNS denotes mice
T5938 30517-30523 NN denotes mutant
T5939 30532-30535 IN denotes due
T5940 30536-30538 IN denotes to
T5941 30539-30546 NNS denotes defects
T5942 30547-30549 IN denotes in
T5943 30550-30553 NN denotes DSB
T5944 30554-30560 NN denotes repair
T5945 30560-30561 . denotes .
T5946 30561-30700 sentence denotes As expected, ovaries of Rec8 Trip13 double mutants were devoid of oocytes as were those from either single mutant (Figure 3B, 3S, and 3T).
T5947 30562-30564 IN denotes As
T5948 30565-30573 VBN denotes expected
T5949 30613-30617 VBD denotes were
T5950 30573-30575 , denotes ,
T5951 30575-30582 NNS denotes ovaries
T5952 30583-30585 IN denotes of
T5953 30586-30590 NN denotes Rec8
T5954 30591-30597 NN denotes Trip13
T5955 30605-30612 NNS denotes mutants
T5956 30598-30604 JJ denotes double
T5957 30618-30624 JJ denotes devoid
T5958 30625-30627 IN denotes of
T5959 30628-30635 NNS denotes oocytes
T5960 30636-30638 IN denotes as
T5961 30639-30643 VBD denotes were
T5962 30644-30649 DT denotes those
T5963 30650-30654 IN denotes from
T5964 30655-30661 CC denotes either
T5965 30669-30675 NN denotes mutant
T5966 30662-30668 JJ denotes single
T5967 30676-30677 -LRB- denotes (
T5968 30684-30686 NN denotes 3B
T5969 30677-30683 NN denotes Figure
T5970 30686-30688 , denotes ,
T5971 30688-30690 NN denotes 3S
T5972 30690-30692 , denotes ,
T5973 30692-30695 CC denotes and
T5974 30696-30698 NN denotes 3T
T5975 30698-30699 -RRB- denotes )
T5976 30699-30700 . denotes .
T6565 30713-30720 JJ denotes Genetic
T6566 30721-30732 NNS denotes experiments
T6567 30750-30758 VBD denotes provided
T6568 30733-30735 IN denotes in
T6569 30736-30738 NNP denotes S.
T6570 30739-30749 NNP denotes cerevisiae
T6571 30759-30767 NN denotes evidence
T6572 30768-30772 IN denotes that
T6573 30798-30806 VBZ denotes monitors
T6574 30773-30776 DT denotes the
T6575 30787-30797 NN denotes checkpoint
T6576 30777-30786 NN denotes pachytene
T6577 30807-30810 CC denotes and
T6578 30811-30819 VBZ denotes responds
T6579 30820-30822 IN denotes to
T6580 30823-30838 JJ denotes recombinational
T6581 30843-30849 NN denotes repair
T6582 30839-30842 NN denotes DSB
T6583 30850-30853 CC denotes and
T6584 30854-30862 NN denotes synapsis
T6585 30863-30876 RB denotes independently
T6586 30876-30877 . denotes .
T6587 30877-31013 sentence denotes Wu and Burgess concluded that the repair checkpoint is RAD17-SAE2 dependent, while the synapsis checkpoint is PCH2-ZIP1 dependent [12].
T6588 30878-30880 NNP denotes Wu
T6589 30893-30902 VBD denotes concluded
T6590 30881-30884 CC denotes and
T6591 30885-30892 NNP denotes Burgess
T6592 30903-30907 IN denotes that
T6593 30930-30932 VBZ denotes is
T6594 30908-30911 DT denotes the
T6595 30919-30929 NN denotes checkpoint
T6596 30912-30918 NN denotes repair
T6597 30933-30938 NN denotes RAD17
T6598 30939-30943 NN denotes SAE2
T6599 30938-30939 HYPH denotes -
T6600 30944-30953 JJ denotes dependent
T6601 30953-30955 , denotes ,
T6602 30955-30960 IN denotes while
T6603 30985-30987 VBZ denotes is
T6604 30961-30964 DT denotes the
T6605 30974-30984 NN denotes checkpoint
T6606 30965-30973 NN denotes synapsis
T6607 30988-30992 NN denotes PCH2
T6608 30993-30997 NN denotes ZIP1
T6609 30992-30993 HYPH denotes -
T6610 30998-31007 JJ denotes dependent
T6611 31008-31009 -LRB- denotes [
T6612 31009-31011 CD denotes 12
T6613 31011-31012 -RRB- denotes ]
T6614 31012-31013 . denotes .
T6615 31013-31233 sentence denotes Of these four genes, SAE2 and ZIP1 do not have clear mammalian orthologs (although SYCP1 may be a functional ortholog of ZIP1), and mutation of the mouse RAD17 ortholog, Rad1, presumably causes embryonic lethality [42].
T6616 31014-31016 IN denotes Of
T6617 31056-31060 VB denotes have
T6618 31017-31022 DT denotes these
T6619 31028-31033 NNS denotes genes
T6620 31023-31027 CD denotes four
T6621 31033-31035 , denotes ,
T6622 31035-31039 NN denotes SAE2
T6623 31040-31043 CC denotes and
T6624 31044-31048 NN denotes ZIP1
T6625 31049-31051 VBP denotes do
T6626 31052-31055 RB denotes not
T6627 31061-31066 JJ denotes clear
T6628 31077-31086 NNS denotes orthologs
T6629 31067-31076 JJ denotes mammalian
T6630 31087-31088 -LRB- denotes (
T6631 31088-31096 IN denotes although
T6632 31107-31109 VB denotes be
T6633 31097-31102 NN denotes SYCP1
T6634 31103-31106 MD denotes may
T6635 31110-31111 DT denotes a
T6636 31123-31131 NN denotes ortholog
T6637 31112-31122 JJ denotes functional
T6638 31132-31134 IN denotes of
T6639 31135-31139 NN denotes ZIP1
T6640 31139-31140 -RRB- denotes )
T6641 31140-31142 , denotes ,
T6642 31142-31145 CC denotes and
T6643 31146-31154 NN denotes mutation
T6644 31201-31207 VBZ denotes causes
T6645 31155-31157 IN denotes of
T6646 31158-31161 DT denotes the
T6647 31174-31182 NN denotes ortholog
T6648 31162-31167 NN denotes mouse
T6649 31168-31173 NN denotes RAD17
T6650 31182-31184 , denotes ,
T6651 31184-31188 NN denotes Rad1
T6652 31188-31190 , denotes ,
T6653 31190-31200 RB denotes presumably
T6654 31208-31217 JJ denotes embryonic
T6655 31218-31227 NN denotes lethality
T6656 31228-31229 -LRB- denotes [
T6657 31229-31231 CD denotes 42
T6658 31231-31232 -RRB- denotes ]
T6659 31232-31233 . denotes .
T6660 31233-31470 sentence denotes Thus, mutational analysis of mouse Pch2 (Trip13), which is also critical for the synapsis checkpoint in C. elegans [2], was the best remaining option to evaluate potential functional conservation in mammalian meiotic checkpoint control.
T6661 31234-31238 RB denotes Thus
T6662 31354-31357 VBD denotes was
T6663 31238-31240 , denotes ,
T6664 31240-31250 JJ denotes mutational
T6665 31251-31259 NN denotes analysis
T6666 31260-31262 IN denotes of
T6667 31263-31268 NN denotes mouse
T6668 31269-31273 NN denotes Pch2
T6669 31274-31275 -LRB- denotes (
T6670 31275-31281 NN denotes Trip13
T6671 31281-31282 -RRB- denotes )
T6672 31282-31284 , denotes ,
T6673 31284-31289 WDT denotes which
T6674 31290-31292 VBZ denotes is
T6675 31293-31297 RB denotes also
T6676 31298-31306 JJ denotes critical
T6677 31307-31310 IN denotes for
T6678 31311-31314 DT denotes the
T6679 31324-31334 NN denotes checkpoint
T6680 31315-31323 NN denotes synapsis
T6681 31335-31337 IN denotes in
T6682 31338-31340 NNP denotes C.
T6683 31341-31348 NNP denotes elegans
T6684 31349-31350 -LRB- denotes [
T6685 31350-31351 CD denotes 2
T6686 31351-31352 -RRB- denotes ]
T6687 31352-31354 , denotes ,
T6688 31358-31361 DT denotes the
T6689 31377-31383 NN denotes option
T6690 31362-31366 JJS denotes best
T6691 31367-31376 JJ denotes remaining
T6692 31384-31386 TO denotes to
T6693 31387-31395 VB denotes evaluate
T6694 31396-31405 JJ denotes potential
T6695 31417-31429 NN denotes conservation
T6696 31406-31416 JJ denotes functional
T6697 31430-31432 IN denotes in
T6698 31433-31442 JJ denotes mammalian
T6699 31462-31469 NN denotes control
T6700 31443-31450 JJ denotes meiotic
T6701 31451-31461 NN denotes checkpoint
T6702 31469-31470 . denotes .
T6703 31470-31575 sentence denotes Our results demonstrate that in mice, the primary meiotic function of TRIP13 is in recombination itself.
T6704 31471-31474 PRP$ denotes Our
T6705 31475-31482 NNS denotes results
T6706 31483-31494 VBP denotes demonstrate
T6707 31495-31499 IN denotes that
T6708 31548-31550 VBZ denotes is
T6709 31500-31502 IN denotes in
T6710 31503-31507 NNS denotes mice
T6711 31507-31509 , denotes ,
T6712 31509-31512 DT denotes the
T6713 31529-31537 NN denotes function
T6714 31513-31520 JJ denotes primary
T6715 31521-31528 JJ denotes meiotic
T6716 31538-31540 IN denotes of
T6717 31541-31547 NN denotes TRIP13
T6718 31551-31553 IN denotes in
T6719 31554-31567 NN denotes recombination
T6720 31568-31574 PRP denotes itself
T6721 31574-31575 . denotes .
T6722 31575-31649 sentence denotes We found no evidence that it is involved in pachytene checkpoint control.
T6723 31576-31578 PRP denotes We
T6724 31579-31584 VBD denotes found
T6725 31585-31587 DT denotes no
T6726 31588-31596 NN denotes evidence
T6727 31597-31601 IN denotes that
T6728 31608-31616 VBN denotes involved
T6729 31602-31604 PRP denotes it
T6730 31605-31607 VBZ denotes is
T6731 31617-31619 IN denotes in
T6732 31620-31629 NN denotes pachytene
T6733 31630-31640 NN denotes checkpoint
T6734 31641-31648 NN denotes control
T6735 31648-31649 . denotes .
T6736 31649-31862 sentence denotes Our data suggest that while recombination events destined to be resolved as COs can proceed normally in Trip13 mutants, DSBs that enter the NCO repair pathway are incompletely resolved or processed inefficiently.
T6737 31650-31653 PRP$ denotes Our
T6738 31654-31658 NNS denotes data
T6739 31659-31666 VBP denotes suggest
T6740 31667-31671 IN denotes that
T6741 31826-31834 VBN denotes resolved
T6742 31672-31677 IN denotes while
T6743 31734-31741 VB denotes proceed
T6744 31678-31691 NN denotes recombination
T6745 31692-31698 NNS denotes events
T6746 31699-31707 VBN denotes destined
T6747 31708-31710 TO denotes to
T6748 31714-31722 VBN denotes resolved
T6749 31711-31713 VB denotes be
T6750 31723-31725 IN denotes as
T6751 31726-31729 NNS denotes COs
T6752 31730-31733 MD denotes can
T6753 31742-31750 RB denotes normally
T6754 31751-31753 IN denotes in
T6755 31754-31760 NN denotes Trip13
T6756 31761-31768 NNS denotes mutants
T6757 31768-31770 , denotes ,
T6758 31770-31774 NNS denotes DSBs
T6759 31775-31779 WDT denotes that
T6760 31780-31785 VBP denotes enter
T6761 31786-31789 DT denotes the
T6762 31801-31808 NN denotes pathway
T6763 31790-31793 NN denotes NCO
T6764 31794-31800 NN denotes repair
T6765 31809-31812 VBP denotes are
T6766 31813-31825 RB denotes incompletely
T6767 31835-31837 CC denotes or
T6768 31838-31847 VBN denotes processed
T6769 31848-31861 RB denotes inefficiently
T6770 31861-31862 . denotes .
T6771 31862-31950 sentence denotes This hypothesis is compatible with current knowledge of meiotic recombination pathways.
T6772 31863-31867 DT denotes This
T6773 31868-31878 NN denotes hypothesis
T6774 31879-31881 VBZ denotes is
T6775 31882-31892 JJ denotes compatible
T6776 31893-31897 IN denotes with
T6777 31898-31905 JJ denotes current
T6778 31906-31915 NN denotes knowledge
T6779 31916-31918 IN denotes of
T6780 31919-31926 JJ denotes meiotic
T6781 31927-31940 NN denotes recombination
T6782 31941-31949 NNS denotes pathways
T6783 31949-31950 . denotes .
T6784 31950-32107 sentence denotes In S. cerevisiae, CO and NCO pathways are distinct [43]; they have different recombination intermediates, and are dependent upon different proteins [44,45].
T6785 31951-31953 IN denotes In
T6786 31989-31992 VBP denotes are
T6787 31954-31956 NNP denotes S.
T6788 31957-31967 NNP denotes cerevisiae
T6789 31967-31969 , denotes ,
T6790 31969-31971 NN denotes CO
T6791 31980-31988 NNS denotes pathways
T6792 31972-31975 CC denotes and
T6793 31976-31979 NN denotes NCO
T6794 32013-32017 VBP denotes have
T6795 31993-32001 JJ denotes distinct
T6796 32002-32003 -LRB- denotes [
T6797 32003-32005 CD denotes 43
T6798 32005-32006 -RRB- denotes ]
T6799 32006-32007 : denotes ;
T6800 32008-32012 PRP denotes they
T6801 32018-32027 JJ denotes different
T6802 32042-32055 NNS denotes intermediates
T6803 32028-32041 NN denotes recombination
T6804 32055-32057 , denotes ,
T6805 32057-32060 CC denotes and
T6806 32061-32064 VBP denotes are
T6807 32065-32074 JJ denotes dependent
T6808 32075-32079 IN denotes upon
T6809 32080-32089 JJ denotes different
T6810 32090-32098 NN denotes proteins
T6811 32099-32100 -LRB- denotes [
T6812 32103-32105 CD denotes 45
T6813 32100-32102 CD denotes 44
T6814 32102-32103 , denotes ,
T6815 32105-32106 -RRB- denotes ]
T6816 32106-32107 . denotes .
T6817 32107-32187 sentence denotes Mice also appear to have independent CO versus NCO recombination pathways [46].
T6818 32108-32112 NNS denotes Mice
T6819 32118-32124 VBP denotes appear
T6820 32113-32117 RB denotes also
T6821 32125-32127 TO denotes to
T6822 32128-32132 VB denotes have
T6823 32133-32144 JJ denotes independent
T6824 32173-32181 NNS denotes pathways
T6825 32145-32147 NN denotes CO
T6826 32148-32154 CC denotes versus
T6827 32155-32158 NN denotes NCO
T6828 32159-32172 NN denotes recombination
T6829 32182-32183 -LRB- denotes [
T6830 32183-32185 CD denotes 46
T6831 32185-32186 -RRB- denotes ]
T6832 32186-32187 . denotes .
T6833 32187-32274 sentence denotes As in yeast, both require SPO11-induced breaks, but only the CO pathway requires MLH1.
T6834 32188-32190 IN denotes As
T6835 32206-32213 VBP denotes require
T6836 32191-32193 IN denotes in
T6837 32194-32199 NN denotes yeast
T6838 32199-32201 , denotes ,
T6839 32201-32205 DT denotes both
T6840 32214-32219 NN denotes SPO11
T6841 32220-32227 VBN denotes induced
T6842 32219-32220 HYPH denotes -
T6843 32228-32234 NNS denotes breaks
T6844 32234-32236 , denotes ,
T6845 32236-32239 CC denotes but
T6846 32240-32244 RB denotes only
T6847 32252-32259 NN denotes pathway
T6848 32245-32248 DT denotes the
T6849 32249-32251 NN denotes CO
T6850 32260-32268 VBZ denotes requires
T6851 32269-32273 NN denotes MLH1
T6852 32273-32274 . denotes .
T6853 32274-32343 sentence denotes Both types of recombinant products are formed by mid-late pachynema.
T6854 32275-32279 DT denotes Both
T6855 32280-32285 NNS denotes types
T6856 32314-32320 VBN denotes formed
T6857 32286-32288 IN denotes of
T6858 32289-32300 JJ denotes recombinant
T6859 32301-32309 NNS denotes products
T6860 32310-32313 VBP denotes are
T6861 32321-32323 IN denotes by
T6862 32324-32327 JJ denotes mid
T6863 32328-32332 JJ denotes late
T6864 32327-32328 SYM denotes -
T6865 32333-32342 NN denotes pachynema
T6866 32342-32343 . denotes .
T6867 32343-32450 sentence denotes Another possibility is that the recombination defects are a result of defective intersister recombination.
T6868 32344-32351 DT denotes Another
T6869 32352-32363 NN denotes possibility
T6870 32364-32366 VBZ denotes is
T6871 32367-32371 IN denotes that
T6872 32398-32401 VBP denotes are
T6873 32372-32375 DT denotes the
T6874 32390-32397 NNS denotes defects
T6875 32376-32389 NN denotes recombination
T6876 32402-32403 DT denotes a
T6877 32404-32410 NN denotes result
T6878 32411-32413 IN denotes of
T6879 32414-32423 JJ denotes defective
T6880 32436-32449 NN denotes recombination
T6881 32424-32435 JJ denotes intersister
T6882 32449-32450 . denotes .
T6883 32450-32515 sentence denotes However, this type of DSB repair is suppressed in meiotic cells.
T6884 32451-32458 RB denotes However
T6885 32487-32497 VBN denotes suppressed
T6886 32458-32460 , denotes ,
T6887 32460-32464 DT denotes this
T6888 32465-32469 NN denotes type
T6889 32470-32472 IN denotes of
T6890 32473-32476 NN denotes DSB
T6891 32477-32483 NN denotes repair
T6892 32484-32486 VBZ denotes is
T6893 32498-32500 IN denotes in
T6894 32501-32508 JJ denotes meiotic
T6895 32509-32514 NNS denotes cells
T6896 32514-32515 . denotes .
T6897 32515-32657 sentence denotes Ablation of RAD54, which mediates intersister recombination in yeast, does not significantly disrupt meiosis in either yeast or mice [47,48].
T6898 32516-32524 NN denotes Ablation
T6899 32609-32616 VB denotes disrupt
T6900 32525-32527 IN denotes of
T6901 32528-32533 NN denotes RAD54
T6902 32533-32535 , denotes ,
T6903 32535-32540 WDT denotes which
T6904 32541-32549 VBZ denotes mediates
T6905 32550-32561 JJ denotes intersister
T6906 32562-32575 NN denotes recombination
T6907 32576-32578 IN denotes in
T6908 32579-32584 NN denotes yeast
T6909 32584-32586 , denotes ,
T6910 32586-32590 VBZ denotes does
T6911 32591-32594 RB denotes not
T6912 32595-32608 RB denotes significantly
T6913 32617-32624 NN denotes meiosis
T6914 32625-32627 IN denotes in
T6915 32628-32634 CC denotes either
T6916 32635-32640 NN denotes yeast
T6917 32641-32643 CC denotes or
T6918 32644-32648 NNS denotes mice
T6919 32649-32650 -LRB- denotes [
T6920 32653-32655 CD denotes 48
T6921 32650-32652 CD denotes 47
T6922 32652-32653 , denotes ,
T6923 32655-32656 -RRB- denotes ]
T6924 32656-32657 . denotes .
T6925 32657-32883 sentence denotes Interestingly, RAD54-deficient spermatocytes display abnormal persistence of RAD51 foci on pachytene chromosomes, similar to those in TRIP13 mice, but there are no deleterious effects on meiotic progression or fertility [49].
T6926 32658-32671 RB denotes Interestingly
T6927 32703-32710 VBP denotes display
T6928 32671-32673 , denotes ,
T6929 32673-32678 NN denotes RAD54
T6930 32679-32688 JJ denotes deficient
T6931 32678-32679 HYPH denotes -
T6932 32689-32702 NNS denotes spermatocytes
T6933 32711-32719 JJ denotes abnormal
T6934 32720-32731 NN denotes persistence
T6935 32732-32734 IN denotes of
T6936 32735-32740 NN denotes RAD51
T6937 32741-32745 NNS denotes foci
T6938 32746-32748 IN denotes on
T6939 32749-32758 NN denotes pachytene
T6940 32759-32770 NNS denotes chromosomes
T6941 32770-32772 , denotes ,
T6942 32772-32779 JJ denotes similar
T6943 32780-32782 IN denotes to
T6944 32783-32788 DT denotes those
T6945 32789-32791 IN denotes in
T6946 32792-32798 NN denotes TRIP13
T6947 32799-32803 NNS denotes mice
T6948 32803-32805 , denotes ,
T6949 32805-32808 CC denotes but
T6950 32809-32814 EX denotes there
T6951 32815-32818 VBP denotes are
T6952 32819-32821 DT denotes no
T6953 32834-32841 NNS denotes effects
T6954 32822-32833 JJ denotes deleterious
T6955 32842-32844 IN denotes on
T6956 32845-32852 JJ denotes meiotic
T6957 32853-32864 NN denotes progression
T6958 32865-32867 CC denotes or
T6959 32868-32877 NN denotes fertility
T6960 32878-32879 -LRB- denotes [
T6961 32879-32881 CD denotes 49
T6962 32881-32882 -RRB- denotes ]
T6963 32882-32883 . denotes .
T6964 32883-32960 sentence denotes Data from budding yeast also indicate that Pch2p functions in recombination.
T6965 32884-32888 NNS denotes Data
T6966 32913-32921 VBP denotes indicate
T6967 32889-32893 IN denotes from
T6968 32894-32901 VBG denotes budding
T6969 32902-32907 NN denotes yeast
T6970 32908-32912 RB denotes also
T6971 32922-32926 IN denotes that
T6972 32933-32942 VBZ denotes functions
T6973 32927-32932 NN denotes Pch2p
T6974 32943-32945 IN denotes in
T6975 32946-32959 NN denotes recombination
T6976 32959-32960 . denotes .
T6977 32960-33079 sentence denotes Deletion of PCH2 delays meiotic progression by ∼2 h in SK1 yeast, and causes a minor decrease in ascus formation [50].
T6978 32961-32969 NN denotes Deletion
T6979 32978-32984 VBZ denotes delays
T6980 32970-32972 IN denotes of
T6981 32973-32977 NN denotes PCH2
T6982 32985-32992 JJ denotes meiotic
T6983 32993-33004 NN denotes progression
T6984 33005-33007 IN denotes by
T6985 33008-33009 SYM denotes ∼
T6986 33009-33010 CD denotes 2
T6987 33011-33012 NN denotes h
T6988 33013-33015 IN denotes in
T6989 33016-33019 NN denotes SK1
T6990 33020-33025 NN denotes yeast
T6991 33025-33027 , denotes ,
T6992 33027-33030 CC denotes and
T6993 33031-33037 VBZ denotes causes
T6994 33038-33039 DT denotes a
T6995 33046-33054 NN denotes decrease
T6996 33040-33045 JJ denotes minor
T6997 33055-33057 IN denotes in
T6998 33058-33063 NN denotes ascus
T6999 33064-33073 NN denotes formation
T7000 33074-33075 -LRB- denotes [
T7001 33075-33077 CD denotes 50
T7002 33077-33078 -RRB- denotes ]
T7003 33078-33079 . denotes .
T7004 33079-33230 sentence denotes DSBs persist >2 h longer in pch2Δ yeast than in wild type, and hyperresection of DSBs in dmc1Δ pch2Δ double mutants is lower than in dmc1Δ cells [10].
T7005 33080-33084 NNS denotes DSBs
T7006 33085-33092 VBP denotes persist
T7007 33093-33094 SYM denotes >
T7008 33094-33095 CD denotes 2
T7009 33096-33097 NN denotes h
T7010 33098-33104 RBR denotes longer
T7011 33105-33107 IN denotes in
T7012 33108-33112 NN denotes pch2
T7013 33114-33119 NN denotes yeast
T7014 33112-33113 SYM denotes Δ
T7015 33120-33124 IN denotes than
T7016 33125-33127 IN denotes in
T7017 33128-33132 JJ denotes wild
T7018 33133-33137 NN denotes type
T7019 33137-33139 , denotes ,
T7020 33139-33142 CC denotes and
T7021 33143-33157 NN denotes hyperresection
T7022 33196-33198 VBZ denotes is
T7023 33158-33160 IN denotes of
T7024 33161-33165 NNS denotes DSBs
T7025 33166-33168 IN denotes in
T7026 33169-33173 NN denotes dmc1
T7027 33175-33179 NN denotes pch2
T7028 33173-33174 SYM denotes Δ
T7029 33188-33195 NNS denotes mutants
T7030 33179-33180 SYM denotes Δ
T7031 33181-33187 JJ denotes double
T7032 33199-33204 JJR denotes lower
T7033 33205-33209 IN denotes than
T7034 33210-33212 IN denotes in
T7035 33213-33217 NN denotes dmc1
T7036 33219-33224 NNS denotes cells
T7037 33217-33218 SYM denotes Δ
T7038 33225-33226 -LRB- denotes [
T7039 33226-33228 CD denotes 10
T7040 33228-33229 -RRB- denotes ]
T7041 33229-33230 . denotes .
T7042 33230-33386 sentence denotes Additionally, it was reported that pch2Δ yeast had a meiosis I delay dependent on the RAD17–SAE2 checkpoint that monitors recombination intermediates [12].
T7043 33231-33243 RB denotes Additionally
T7044 33252-33260 VBN denotes reported
T7045 33243-33245 , denotes ,
T7046 33245-33247 PRP denotes it
T7047 33248-33251 VBD denotes was
T7048 33261-33265 IN denotes that
T7049 33278-33281 VBD denotes had
T7050 33266-33270 NN denotes pch2
T7051 33270-33271 NN denotes Δ
T7052 33272-33277 NN denotes yeast
T7053 33282-33283 DT denotes a
T7054 33294-33299 NN denotes delay
T7055 33284-33291 NN denotes meiosis
T7056 33292-33293 CD denotes I
T7057 33300-33309 JJ denotes dependent
T7058 33310-33312 IN denotes on
T7059 33313-33316 DT denotes the
T7060 33328-33338 NN denotes checkpoint
T7061 33317-33322 NN denotes RAD17
T7062 33323-33327 NN denotes SAE2
T7063 33322-33323 HYPH denotes –
T7064 33339-33343 WDT denotes that
T7065 33344-33352 VBZ denotes monitors
T7066 33353-33366 NN denotes recombination
T7067 33367-33380 NNS denotes intermediates
T7068 33381-33382 -LRB- denotes [
T7069 33382-33384 CD denotes 12
T7070 33384-33385 -RRB- denotes ]
T7071 33385-33386 . denotes .
T7072 33386-33459 sentence denotes However, the exact role of TRIP13 (or Pch2) in recombination is unclear.
T7073 33387-33394 RB denotes However
T7074 33448-33450 VBZ denotes is
T7075 33394-33396 , denotes ,
T7076 33396-33399 DT denotes the
T7077 33406-33410 NN denotes role
T7078 33400-33405 JJ denotes exact
T7079 33411-33413 IN denotes of
T7080 33414-33420 NN denotes TRIP13
T7081 33421-33422 -LRB- denotes (
T7082 33422-33424 CC denotes or
T7083 33425-33429 NN denotes Pch2
T7084 33429-33430 -RRB- denotes )
T7085 33431-33433 IN denotes in
T7086 33434-33447 NN denotes recombination
T7087 33451-33458 JJ denotes unclear
T7088 33458-33459 . denotes .
T7089 33459-33812 sentence denotes Because synapsis occurs in TRIP13-deficient spermatocytes and is dependent on DSB formation (activity of SPO11 and MEI1), we suggest that TRIP13 functions after homology recognition and strand exchange, and that recombination events entering the CO repair pathway are either completed or nearly so (because OA treated resulted in bivalent chromosomes).
T7090 33460-33467 IN denotes Because
T7091 33477-33483 VBZ denotes occurs
T7092 33468-33476 NN denotes synapsis
T7093 33585-33592 VBP denotes suggest
T7094 33484-33486 IN denotes in
T7095 33487-33493 NN denotes TRIP13
T7096 33494-33503 JJ denotes deficient
T7097 33493-33494 HYPH denotes -
T7098 33504-33517 NNS denotes spermatocytes
T7099 33518-33521 CC denotes and
T7100 33522-33524 VBZ denotes is
T7101 33525-33534 JJ denotes dependent
T7102 33535-33537 IN denotes on
T7103 33538-33541 NN denotes DSB
T7104 33542-33551 NN denotes formation
T7105 33552-33553 -LRB- denotes (
T7106 33553-33561 NN denotes activity
T7107 33562-33564 IN denotes of
T7108 33565-33570 NN denotes SPO11
T7109 33571-33574 CC denotes and
T7110 33575-33579 NN denotes MEI1
T7111 33579-33580 -RRB- denotes )
T7112 33580-33582 , denotes ,
T7113 33582-33584 PRP denotes we
T7114 33593-33597 IN denotes that
T7115 33605-33614 VBZ denotes functions
T7116 33598-33604 NN denotes TRIP13
T7117 33615-33620 IN denotes after
T7118 33621-33629 NN denotes homology
T7119 33630-33641 NN denotes recognition
T7120 33642-33645 CC denotes and
T7121 33646-33652 NN denotes strand
T7122 33653-33661 NN denotes exchange
T7123 33661-33663 , denotes ,
T7124 33663-33666 CC denotes and
T7125 33667-33671 IN denotes that
T7126 33724-33727 VBP denotes are
T7127 33672-33685 NN denotes recombination
T7128 33686-33692 NNS denotes events
T7129 33693-33701 VBG denotes entering
T7130 33702-33705 DT denotes the
T7131 33716-33723 NN denotes pathway
T7132 33706-33708 NN denotes CO
T7133 33709-33715 NN denotes repair
T7134 33728-33734 RB denotes either
T7135 33735-33744 VBN denotes completed
T7136 33745-33747 CC denotes or
T7137 33748-33754 RB denotes nearly
T7138 33755-33757 RB denotes so
T7139 33758-33759 -LRB- denotes (
T7140 33759-33766 IN denotes because
T7141 33778-33786 VBD denotes resulted
T7142 33767-33769 NN denotes OA
T7143 33770-33777 VBN denotes treated
T7144 33787-33789 IN denotes in
T7145 33790-33798 JJ denotes bivalent
T7146 33799-33810 NNS denotes chromosomes
T7147 33810-33811 -RRB- denotes )
T7148 33811-33812 . denotes .
T7149 33812-33964 sentence denotes One possibility for TRIP13′s role in recombination is that it is directly involved in a step specific to resolution of NCO recombination intermediates.
T7150 33813-33816 CD denotes One
T7151 33817-33828 NN denotes possibility
T7152 33864-33866 VBZ denotes is
T7153 33829-33832 IN denotes for
T7154 33833-33839 NN denotes TRIP13
T7155 33842-33846 NN denotes role
T7156 33839-33841 POS denotes ′s
T7157 33847-33849 IN denotes in
T7158 33850-33863 NN denotes recombination
T7159 33867-33871 IN denotes that
T7160 33887-33895 VBN denotes involved
T7161 33872-33874 PRP denotes it
T7162 33875-33877 VBZ denotes is
T7163 33878-33886 RB denotes directly
T7164 33896-33898 IN denotes in
T7165 33899-33900 DT denotes a
T7166 33901-33905 NN denotes step
T7167 33906-33914 JJ denotes specific
T7168 33915-33917 IN denotes to
T7169 33918-33928 NN denotes resolution
T7170 33929-33931 IN denotes of
T7171 33932-33935 NN denotes NCO
T7172 33936-33949 NN denotes recombination
T7173 33950-33963 NNS denotes intermediates
T7174 33963-33964 . denotes .
T7175 33964-34160 sentence denotes Another possibility is that TRIP13 is required for disassembly of NCO recombinational repair complexes [51] containing those proteins that persist abnormally on Trip13Gt/Gt pachytene chromosomes.
T7176 33965-33972 DT denotes Another
T7177 33973-33984 NN denotes possibility
T7178 33985-33987 VBZ denotes is
T7179 33988-33992 IN denotes that
T7180 34003-34011 VBN denotes required
T7181 33993-33999 NN denotes TRIP13
T7182 34000-34002 VBZ denotes is
T7183 34012-34015 IN denotes for
T7184 34016-34027 NN denotes disassembly
T7185 34028-34030 IN denotes of
T7186 34031-34034 NN denotes NCO
T7187 34035-34050 JJ denotes recombinational
T7188 34051-34057 NN denotes repair
T7189 34058-34067 NNS denotes complexes
T7190 34068-34069 -LRB- denotes [
T7191 34069-34071 CD denotes 51
T7192 34071-34072 -RRB- denotes ]
T7193 34073-34083 VBG denotes containing
T7194 34084-34089 DT denotes those
T7195 34090-34098 NN denotes proteins
T7196 34099-34103 WDT denotes that
T7197 34104-34111 VBP denotes persist
T7198 34112-34122 RB denotes abnormally
T7199 34123-34125 IN denotes on
T7200 34126-34134 NN denotes Trip13Gt
T7201 34135-34137 NN denotes Gt
T7202 34134-34135 HYPH denotes /
T7203 34148-34159 NNS denotes chromosomes
T7204 34138-34147 NN denotes pachytene
T7205 34159-34160 . denotes .
T7206 34160-34315 sentence denotes Notably, TRIP13 has two putative ATPase domains, a signature of AAA-ATPase ClpA/B chaperones that perform protein or protein/DNA complex disassembly [52].
T7207 34161-34168 RB denotes Notably
T7208 34177-34180 VBZ denotes has
T7209 34168-34170 , denotes ,
T7210 34170-34176 NN denotes TRIP13
T7211 34181-34184 CD denotes two
T7212 34201-34208 NNS denotes domains
T7213 34185-34193 JJ denotes putative
T7214 34194-34200 NN denotes ATPase
T7215 34208-34210 , denotes ,
T7216 34210-34211 DT denotes a
T7217 34212-34221 NN denotes signature
T7218 34222-34224 IN denotes of
T7219 34225-34228 NN denotes AAA
T7220 34229-34235 NN denotes ATPase
T7221 34228-34229 HYPH denotes -
T7222 34243-34253 NNS denotes chaperones
T7223 34236-34240 NN denotes ClpA
T7224 34241-34242 NN denotes B
T7225 34240-34241 HYPH denotes /
T7226 34254-34258 WDT denotes that
T7227 34259-34266 VBP denotes perform
T7228 34267-34274 NN denotes protein
T7229 34298-34309 NN denotes disassembly
T7230 34275-34277 CC denotes or
T7231 34278-34285 NN denotes protein
T7232 34286-34289 NN denotes DNA
T7233 34285-34286 HYPH denotes /
T7234 34290-34297 NN denotes complex
T7235 34310-34311 -LRB- denotes [
T7236 34311-34313 CD denotes 52
T7237 34313-34314 -RRB- denotes ]
T7238 34314-34315 . denotes .
T7239 34315-34475 sentence denotes These potential recombination roles might not be limited to meiosis, since Trip13 is widely transcribed and the mutant animals exhibited developmental defects.
T7240 34316-34321 DT denotes These
T7241 34346-34351 NNS denotes roles
T7242 34322-34331 JJ denotes potential
T7243 34332-34345 NN denotes recombination
T7244 34365-34372 VBN denotes limited
T7245 34352-34357 MD denotes might
T7246 34358-34361 RB denotes not
T7247 34362-34364 VB denotes be
T7248 34373-34375 IN denotes to
T7249 34376-34383 NN denotes meiosis
T7250 34383-34385 , denotes ,
T7251 34385-34390 IN denotes since
T7252 34408-34419 VBN denotes transcribed
T7253 34391-34397 NN denotes Trip13
T7254 34398-34400 VBZ denotes is
T7255 34401-34407 RB denotes widely
T7256 34420-34423 CC denotes and
T7257 34424-34427 DT denotes the
T7258 34435-34442 NNS denotes animals
T7259 34428-34434 NN denotes mutant
T7260 34443-34452 VBD denotes exhibited
T7261 34453-34466 JJ denotes developmental
T7262 34467-34474 NNS denotes defects
T7263 34474-34475 . denotes .
T7264 34475-34626 sentence denotes Finally, TRIP13 might play an indirect role, such as providing a “licensing” signal for the resolution of NCO intermediates and completion of meiosis.
T7265 34476-34483 RB denotes Finally
T7266 34498-34502 VB denotes play
T7267 34483-34485 , denotes ,
T7268 34485-34491 NN denotes TRIP13
T7269 34492-34497 MD denotes might
T7270 34503-34505 DT denotes an
T7271 34515-34519 NN denotes role
T7272 34506-34514 JJ denotes indirect
T7273 34519-34521 , denotes ,
T7274 34521-34525 JJ denotes such
T7275 34526-34528 IN denotes as
T7276 34529-34538 VBG denotes providing
T7277 34539-34540 DT denotes a
T7278 34553-34559 NN denotes signal
T7279 34541-34542 `` denotes “
T7280 34542-34551 NN denotes licensing
T7281 34551-34552 '' denotes ”
T7282 34560-34563 IN denotes for
T7283 34564-34567 DT denotes the
T7284 34568-34578 NN denotes resolution
T7285 34579-34581 IN denotes of
T7286 34582-34585 NN denotes NCO
T7287 34586-34599 NNS denotes intermediates
T7288 34600-34603 CC denotes and
T7289 34604-34614 NN denotes completion
T7290 34615-34617 IN denotes of
T7291 34618-34625 NN denotes meiosis
T7292 34625-34626 . denotes .
T7293 34626-34767 sentence denotes Regarding the cause of cell death in Trip13 mutants, our data indicate that this is triggered by defective DSB repair rather than asynapsis.
T7294 34627-34636 VBG denotes Regarding
T7295 34689-34697 VBP denotes indicate
T7296 34637-34640 DT denotes the
T7297 34641-34646 NN denotes cause
T7298 34647-34649 IN denotes of
T7299 34650-34654 NN denotes cell
T7300 34655-34660 NN denotes death
T7301 34661-34663 IN denotes in
T7302 34664-34670 NN denotes Trip13
T7303 34671-34678 NNS denotes mutants
T7304 34678-34680 , denotes ,
T7305 34680-34683 PRP$ denotes our
T7306 34684-34688 NNS denotes data
T7307 34698-34702 IN denotes that
T7308 34711-34720 VBN denotes triggered
T7309 34703-34707 DT denotes this
T7310 34708-34710 VBZ denotes is
T7311 34721-34723 IN denotes by
T7312 34724-34733 JJ denotes defective
T7313 34738-34744 NN denotes repair
T7314 34734-34737 NN denotes DSB
T7315 34745-34751 RB denotes rather
T7316 34752-34756 IN denotes than
T7317 34757-34766 NN denotes asynapsis
T7318 34766-34767 . denotes .
T7319 34767-34928 sentence denotes We base this conclusion on two observations: (1) oocyte elimination is dependent upon DSB formation and (2) synapsis is normal in spermatocytes of adult testes.
T7320 34768-34770 PRP denotes We
T7321 34771-34775 VBP denotes base
T7322 34836-34838 VBZ denotes is
T7323 34776-34780 DT denotes this
T7324 34781-34791 NN denotes conclusion
T7325 34792-34794 IN denotes on
T7326 34795-34798 CD denotes two
T7327 34799-34811 NNS denotes observations
T7328 34811-34813 : denotes :
T7329 34813-34814 -LRB- denotes (
T7330 34814-34815 LS denotes 1
T7331 34815-34816 -RRB- denotes )
T7332 34817-34823 NN denotes oocyte
T7333 34824-34835 NN denotes elimination
T7334 34839-34848 JJ denotes dependent
T7335 34849-34853 IN denotes upon
T7336 34854-34857 NN denotes DSB
T7337 34858-34867 NN denotes formation
T7338 34868-34871 CC denotes and
T7339 34872-34873 -LRB- denotes (
T7340 34873-34874 LS denotes 2
T7341 34885-34887 VBZ denotes is
T7342 34874-34875 -RRB- denotes )
T7343 34876-34884 NN denotes synapsis
T7344 34888-34894 JJ denotes normal
T7345 34895-34897 IN denotes in
T7346 34898-34911 NNS denotes spermatocytes
T7347 34912-34914 IN denotes of
T7348 34915-34920 JJ denotes adult
T7349 34921-34927 NNS denotes testes
T7350 34927-34928 . denotes .
T7351 34928-35052 sentence denotes Indeed, this mutant is unique in that recombination defects occur in the absence of asynapsis (e.g., as in Dmc1 knockouts).
T7352 34929-34935 RB denotes Indeed
T7353 34949-34951 VBZ denotes is
T7354 34935-34937 , denotes ,
T7355 34937-34941 DT denotes this
T7356 34942-34948 NN denotes mutant
T7357 34952-34958 JJ denotes unique
T7358 34959-34961 IN denotes in
T7359 34989-34994 VBP denotes occur
T7360 34962-34966 IN denotes that
T7361 34967-34980 NN denotes recombination
T7362 34981-34988 NNS denotes defects
T7363 34995-34997 IN denotes in
T7364 34998-35001 DT denotes the
T7365 35002-35009 NN denotes absence
T7366 35010-35012 IN denotes of
T7367 35013-35022 NN denotes asynapsis
T7368 35023-35024 -LRB- denotes (
T7369 35030-35032 IN denotes as
T7370 35024-35028 FW denotes e.g.
T7371 35028-35030 , denotes ,
T7372 35033-35035 IN denotes in
T7373 35036-35040 NN denotes Dmc1
T7374 35041-35050 NNS denotes knockouts
T7375 35050-35051 -RRB- denotes )
T7376 35051-35052 . denotes .
T7377 35052-35194 sentence denotes Thus, the Trip13 mutant provides the first evidence that unrepaired DNA damage alone can trigger the mammalian pachytene checkpoint response.
T7378 35053-35057 RB denotes Thus
T7379 35077-35085 VBZ denotes provides
T7380 35057-35059 , denotes ,
T7381 35059-35062 DT denotes the
T7382 35070-35076 NN denotes mutant
T7383 35063-35069 NN denotes Trip13
T7384 35086-35089 DT denotes the
T7385 35096-35104 NN denotes evidence
T7386 35090-35095 JJ denotes first
T7387 35105-35109 IN denotes that
T7388 35142-35149 VB denotes trigger
T7389 35110-35120 JJ denotes unrepaired
T7390 35125-35131 NN denotes damage
T7391 35121-35124 NN denotes DNA
T7392 35132-35137 RB denotes alone
T7393 35138-35141 MD denotes can
T7394 35150-35153 DT denotes the
T7395 35185-35193 NN denotes response
T7396 35154-35163 JJ denotes mammalian
T7397 35164-35173 NN denotes pachytene
T7398 35174-35184 NN denotes checkpoint
T7399 35193-35194 . denotes .
T7400 35194-35384 sentence denotes Furthermore, our results allow us to conclude that oocytes and spermatocytes share a similar, if not identical, DNA damage pachytene checkpoint that is decoupled from a synapsis checkpoint.
T7401 35195-35206 RB denotes Furthermore
T7402 35220-35225 VBP denotes allow
T7403 35206-35208 , denotes ,
T7404 35208-35211 PRP$ denotes our
T7405 35212-35219 NNS denotes results
T7406 35226-35228 PRP denotes us
T7407 35232-35240 VB denotes conclude
T7408 35229-35231 TO denotes to
T7409 35241-35245 IN denotes that
T7410 35272-35277 VBP denotes share
T7411 35246-35253 NNS denotes oocytes
T7412 35254-35257 CC denotes and
T7413 35258-35271 NNS denotes spermatocytes
T7414 35278-35279 DT denotes a
T7415 35328-35338 NN denotes checkpoint
T7416 35280-35287 JJ denotes similar
T7417 35287-35289 , denotes ,
T7418 35289-35291 IN denotes if
T7419 35292-35295 RB denotes not
T7420 35296-35305 JJ denotes identical
T7421 35305-35307 , denotes ,
T7422 35307-35310 NN denotes DNA
T7423 35311-35317 NN denotes damage
T7424 35318-35327 NN denotes pachytene
T7425 35339-35343 WDT denotes that
T7426 35347-35356 VBN denotes decoupled
T7427 35344-35346 VBZ denotes is
T7428 35357-35361 IN denotes from
T7429 35362-35363 DT denotes a
T7430 35373-35383 NN denotes checkpoint
T7431 35364-35372 NN denotes synapsis
T7432 35383-35384 . denotes .
T7433 35384-35643 sentence denotes Interestingly, we found that OA treatment of Trip13Gt/Gt spermatocytes could propel them into MI, despite a report that the same did not occur when wild-type pachytene spermatocytes were treated with the DSB-inducing agents gamma radiation or etoposide [53].
T7434 35385-35398 RB denotes Interestingly
T7435 35403-35408 VBD denotes found
T7436 35398-35400 , denotes ,
T7437 35400-35402 PRP denotes we
T7438 35409-35413 IN denotes that
T7439 35462-35468 VB denotes propel
T7440 35414-35416 NN denotes OA
T7441 35417-35426 NN denotes treatment
T7442 35427-35429 IN denotes of
T7443 35430-35438 NN denotes Trip13Gt
T7444 35439-35441 NN denotes Gt
T7445 35438-35439 HYPH denotes /
T7446 35442-35455 NNS denotes spermatocytes
T7447 35456-35461 MD denotes could
T7448 35469-35473 PRP denotes them
T7449 35474-35478 IN denotes into
T7450 35479-35481 NN denotes MI
T7451 35481-35483 , denotes ,
T7452 35483-35490 IN denotes despite
T7453 35491-35492 DT denotes a
T7454 35493-35499 NN denotes report
T7455 35500-35504 IN denotes that
T7456 35522-35527 VB denotes occur
T7457 35505-35508 DT denotes the
T7458 35509-35513 JJ denotes same
T7459 35514-35517 VBD denotes did
T7460 35518-35521 RB denotes not
T7461 35528-35532 WRB denotes when
T7462 35572-35579 VBN denotes treated
T7463 35533-35537 JJ denotes wild
T7464 35538-35542 NN denotes type
T7465 35537-35538 HYPH denotes -
T7466 35553-35566 NNS denotes spermatocytes
T7467 35543-35552 NN denotes pachytene
T7468 35567-35571 VBD denotes were
T7469 35580-35584 IN denotes with
T7470 35585-35588 DT denotes the
T7471 35602-35608 NNS denotes agents
T7472 35589-35592 NN denotes DSB
T7473 35593-35601 VBG denotes inducing
T7474 35592-35593 HYPH denotes -
T7475 35609-35614 NN denotes gamma
T7476 35615-35624 NN denotes radiation
T7477 35625-35627 CC denotes or
T7478 35628-35637 NN denotes etoposide
T7479 35638-35639 -LRB- denotes [
T7480 35639-35641 CD denotes 53
T7481 35641-35642 -RRB- denotes ]
T7482 35642-35643 . denotes .
T7483 35643-35849 sentence denotes It is possible that the nascent induction of DSBs in pachynema evokes a checkpoint response that cannot be bypassed by OA, whereas the post-strand invasion lesions in TRIP13-deficient spermatocytes do not.
T7484 35644-35646 PRP denotes It
T7485 35647-35649 VBZ denotes is
T7486 35650-35658 JJ denotes possible
T7487 35659-35663 IN denotes that
T7488 35707-35713 VBZ denotes evokes
T7489 35664-35667 DT denotes the
T7490 35676-35685 NN denotes induction
T7491 35668-35675 JJ denotes nascent
T7492 35686-35688 IN denotes of
T7493 35689-35693 NNS denotes DSBs
T7494 35694-35696 IN denotes in
T7495 35697-35706 NN denotes pachynema
T7496 35714-35715 DT denotes a
T7497 35727-35735 NN denotes response
T7498 35716-35726 NN denotes checkpoint
T7499 35736-35740 WDT denotes that
T7500 35751-35759 VBN denotes bypassed
T7501 35741-35744 MD denotes can
T7502 35744-35747 RB denotes not
T7503 35748-35750 VB denotes be
T7504 35760-35762 IN denotes by
T7505 35763-35765 NN denotes OA
T7506 35765-35767 , denotes ,
T7507 35767-35774 IN denotes whereas
T7508 35842-35844 VBP denotes do
T7509 35775-35778 DT denotes the
T7510 35800-35807 NNS denotes lesions
T7511 35779-35790 JJ denotes post-strand
T7512 35791-35799 RB denotes invasion
T7513 35808-35810 IN denotes in
T7514 35811-35817 NN denotes TRIP13
T7515 35818-35827 JJ denotes deficient
T7516 35817-35818 HYPH denotes -
T7517 35828-35841 NNS denotes spermatocytes
T7518 35845-35848 RB denotes not
T7519 35848-35849 . denotes .
T7520 35849-36015 sentence denotes TRIP13 was originally discovered to be an interactor with rat thyroid receptor beta (THRB; [54]), but the relationship between THRB and TRIP13 in meiosis is unknown.
T7521 35850-35856 NN denotes TRIP13
T7522 35872-35882 VBN denotes discovered
T7523 35857-35860 VBD denotes was
T7524 35861-35871 RB denotes originally
T7525 35883-35885 TO denotes to
T7526 35886-35888 VB denotes be
T7527 35889-35891 DT denotes an
T7528 35892-35902 NN denotes interactor
T7529 35903-35907 IN denotes with
T7530 35908-35911 NN denotes rat
T7531 35929-35933 NN denotes beta
T7532 35912-35919 NN denotes thyroid
T7533 35920-35928 NN denotes receptor
T7534 35934-35935 -LRB- denotes (
T7535 35935-35939 NN denotes THRB
T7536 35939-35940 : denotes ;
T7537 35941-35942 -LRB- denotes [
T7538 35942-35944 CD denotes 54
T7539 35944-35945 -RRB- denotes ]
T7540 35945-35946 -RRB- denotes )
T7541 35946-35948 , denotes ,
T7542 35948-35951 CC denotes but
T7543 35952-35955 DT denotes the
T7544 35956-35968 NN denotes relationship
T7545 36004-36006 VBZ denotes is
T7546 35969-35976 IN denotes between
T7547 35977-35981 NN denotes THRB
T7548 35982-35985 CC denotes and
T7549 35986-35992 NN denotes TRIP13
T7550 35993-35995 IN denotes in
T7551 35996-36003 NN denotes meiosis
T7552 36007-36014 JJ denotes unknown
T7553 36014-36015 . denotes .
T7554 36015-36360 sentence denotes Interestingly, we observed that THRB is distributed diffusely throughout wild-type spermatocyte nuclei but is excluded from the XY (sex) body (unpublished observations), a compartmentalized nuclear domain beginning in pachynema, in which the sex chromosomes become heterochromatinized and transcriptionally silenced in the process of MSCI [55].
T7555 36016-36029 RB denotes Interestingly
T7556 36034-36042 VBD denotes observed
T7557 36029-36031 , denotes ,
T7558 36031-36033 PRP denotes we
T7559 36043-36047 IN denotes that
T7560 36056-36067 VBN denotes distributed
T7561 36048-36052 NN denotes THRB
T7562 36053-36055 VBZ denotes is
T7563 36068-36077 RB denotes diffusely
T7564 36078-36088 IN denotes throughout
T7565 36089-36093 JJ denotes wild
T7566 36094-36098 NN denotes type
T7567 36093-36094 HYPH denotes -
T7568 36112-36118 NNS denotes nuclei
T7569 36099-36111 NN denotes spermatocyte
T7570 36119-36122 CC denotes but
T7571 36123-36125 VBZ denotes is
T7572 36126-36134 VBN denotes excluded
T7573 36135-36139 IN denotes from
T7574 36140-36143 DT denotes the
T7575 36153-36157 NN denotes body
T7576 36144-36146 NN denotes XY
T7577 36147-36148 -LRB- denotes (
T7578 36148-36151 NN denotes sex
T7579 36151-36152 -RRB- denotes )
T7580 36158-36159 -LRB- denotes (
T7581 36171-36183 NNS denotes observations
T7582 36159-36170 JJ denotes unpublished
T7583 36183-36184 -RRB- denotes )
T7584 36184-36186 , denotes ,
T7585 36186-36187 DT denotes a
T7586 36214-36220 NN denotes domain
T7587 36188-36205 VBN denotes compartmentalized
T7588 36206-36213 JJ denotes nuclear
T7589 36221-36230 VBG denotes beginning
T7590 36231-36233 IN denotes in
T7591 36234-36243 NN denotes pachynema
T7592 36243-36245 , denotes ,
T7593 36245-36247 IN denotes in
T7594 36274-36280 VBP denotes become
T7595 36248-36253 WDT denotes which
T7596 36254-36257 DT denotes the
T7597 36262-36273 NNS denotes chromosomes
T7598 36258-36261 NN denotes sex
T7599 36281-36300 VBN denotes heterochromatinized
T7600 36301-36304 CC denotes and
T7601 36305-36322 RB denotes transcriptionally
T7602 36323-36331 VBN denotes silenced
T7603 36332-36334 IN denotes in
T7604 36335-36338 DT denotes the
T7605 36339-36346 NN denotes process
T7606 36347-36349 IN denotes of
T7607 36350-36354 NN denotes MSCI
T7608 36355-36356 -LRB- denotes [
T7609 36356-36358 CD denotes 55
T7610 36358-36359 -RRB- denotes ]
T7611 36359-36360 . denotes .
T7612 36360-36517 sentence denotes However, the XY body appeared intact in most mutant spermatocytes upon probing with several markers of XY heterochromatinization (unpublished observations).
T7613 36361-36368 RB denotes However
T7614 36382-36390 VBD denotes appeared
T7615 36368-36370 , denotes ,
T7616 36370-36373 DT denotes the
T7617 36377-36381 NN denotes body
T7618 36374-36376 NN denotes XY
T7619 36391-36397 JJ denotes intact
T7620 36398-36400 IN denotes in
T7621 36401-36405 JJS denotes most
T7622 36413-36426 NNS denotes spermatocytes
T7623 36406-36412 NN denotes mutant
T7624 36427-36431 IN denotes upon
T7625 36432-36439 VBG denotes probing
T7626 36440-36444 IN denotes with
T7627 36445-36452 JJ denotes several
T7628 36453-36460 NNS denotes markers
T7629 36461-36463 IN denotes of
T7630 36464-36466 NN denotes XY
T7631 36467-36489 NN denotes heterochromatinization
T7632 36490-36491 -LRB- denotes (
T7633 36503-36515 NNS denotes observations
T7634 36491-36502 JJ denotes unpublished
T7635 36515-36516 -RRB- denotes )
T7636 36516-36517 . denotes .
T7637 36517-36670 sentence denotes Considering that THRB knockout mice are viable and fertile [56], the functional relationship between TRIP13 and its receptor THRB in meiosis is unclear.
T7638 36518-36529 VBG denotes Considering
T7639 36659-36661 VBZ denotes is
T7640 36530-36534 IN denotes that
T7641 36554-36557 VBP denotes are
T7642 36535-36539 NN denotes THRB
T7643 36540-36548 NN denotes knockout
T7644 36549-36553 NNS denotes mice
T7645 36558-36564 JJ denotes viable
T7646 36565-36568 CC denotes and
T7647 36569-36576 JJ denotes fertile
T7648 36577-36578 -LRB- denotes [
T7649 36578-36580 CD denotes 56
T7650 36580-36581 -RRB- denotes ]
T7651 36581-36583 , denotes ,
T7652 36583-36586 DT denotes the
T7653 36598-36610 NN denotes relationship
T7654 36587-36597 JJ denotes functional
T7655 36611-36618 IN denotes between
T7656 36619-36625 NN denotes TRIP13
T7657 36626-36629 CC denotes and
T7658 36630-36633 PRP$ denotes its
T7659 36634-36642 NN denotes receptor
T7660 36643-36647 NN denotes THRB
T7661 36648-36650 IN denotes in
T7662 36651-36658 NN denotes meiosis
T7663 36662-36669 JJ denotes unclear
T7664 36669-36670 . denotes .
T7665 36670-36814 sentence denotes Given the high similarity of PCH2 orthologs throughout the eukaryotic world, one or more essential functions of this protein must be conserved.
T7666 36671-36676 VBN denotes Given
T7667 36804-36813 VBN denotes conserved
T7668 36677-36680 DT denotes the
T7669 36686-36696 NN denotes similarity
T7670 36681-36685 JJ denotes high
T7671 36697-36699 IN denotes of
T7672 36700-36704 NN denotes PCH2
T7673 36705-36714 NNS denotes orthologs
T7674 36715-36725 IN denotes throughout
T7675 36726-36729 DT denotes the
T7676 36741-36746 NN denotes world
T7677 36730-36740 JJ denotes eukaryotic
T7678 36746-36748 , denotes ,
T7679 36748-36751 CD denotes one
T7680 36770-36779 NNS denotes functions
T7681 36752-36754 CC denotes or
T7682 36755-36759 JJR denotes more
T7683 36760-36769 JJ denotes essential
T7684 36780-36782 IN denotes of
T7685 36783-36787 DT denotes this
T7686 36788-36795 NN denotes protein
T7687 36796-36800 MD denotes must
T7688 36801-36803 VB denotes be
T7689 36813-36814 . denotes .
T7690 36814-36985 sentence denotes Since TRIP13 does not exhibit checkpoint function in mice, we surmise that the TRIP13/PCH2 ancestral protein had a function in recombination that persists to the present.
T7691 36815-36820 IN denotes Since
T7692 36837-36844 VB denotes exhibit
T7693 36821-36827 NN denotes TRIP13
T7694 36828-36832 VBZ denotes does
T7695 36833-36836 RB denotes not
T7696 36877-36884 VBP denotes surmise
T7697 36845-36855 NN denotes checkpoint
T7698 36856-36864 NN denotes function
T7699 36865-36867 IN denotes in
T7700 36868-36872 NNS denotes mice
T7701 36872-36874 , denotes ,
T7702 36874-36876 PRP denotes we
T7703 36885-36889 IN denotes that
T7704 36924-36927 VBD denotes had
T7705 36890-36893 DT denotes the
T7706 36916-36923 NN denotes protein
T7707 36894-36900 NN denotes TRIP13
T7708 36901-36905 NN denotes PCH2
T7709 36900-36901 HYPH denotes /
T7710 36906-36915 JJ denotes ancestral
T7711 36928-36929 DT denotes a
T7712 36930-36938 NN denotes function
T7713 36939-36941 IN denotes in
T7714 36942-36955 NN denotes recombination
T7715 36956-36960 WDT denotes that
T7716 36961-36969 VBZ denotes persists
T7717 36970-36972 IN denotes to
T7718 36973-36976 DT denotes the
T7719 36977-36984 JJ denotes present
T7720 36984-36985 . denotes .
T7721 36985-37296 sentence denotes Notably, A. thaliana does not appear to have a meiotic checkpoint activity that eliminates mutant meiocytes in a manner analogous to organisms such as mice, budding yeast, and female Drosophila [11,57], and mammalian TRIP13 is more similar to Arabidopsis PCH2 than the fly or worm proteins (Figures 1A and S1).
T7722 36986-36993 RB denotes Notably
T7723 37016-37022 VB denotes appear
T7724 36993-36995 , denotes ,
T7725 36995-36997 NNP denotes A.
T7726 36998-37006 NNP denotes thaliana
T7727 37007-37011 VBZ denotes does
T7728 37012-37015 RB denotes not
T7729 37023-37025 TO denotes to
T7730 37026-37030 VB denotes have
T7731 37031-37032 DT denotes a
T7732 37052-37060 NN denotes activity
T7733 37033-37040 JJ denotes meiotic
T7734 37041-37051 NN denotes checkpoint
T7735 37061-37065 WDT denotes that
T7736 37066-37076 VBZ denotes eliminates
T7737 37077-37083 NN denotes mutant
T7738 37084-37093 NNS denotes meiocytes
T7739 37094-37096 IN denotes in
T7740 37097-37098 DT denotes a
T7741 37099-37105 NN denotes manner
T7742 37106-37115 JJ denotes analogous
T7743 37116-37118 IN denotes to
T7744 37119-37128 NNS denotes organisms
T7745 37129-37133 JJ denotes such
T7746 37134-37136 IN denotes as
T7747 37137-37141 NNS denotes mice
T7748 37141-37143 , denotes ,
T7749 37143-37150 VBG denotes budding
T7750 37151-37156 NN denotes yeast
T7751 37156-37158 , denotes ,
T7752 37158-37161 CC denotes and
T7753 37162-37168 JJ denotes female
T7754 37169-37179 NNP denotes Drosophila
T7755 37180-37181 -LRB- denotes [
T7756 37184-37186 CD denotes 57
T7757 37181-37183 CD denotes 11
T7758 37183-37184 , denotes ,
T7759 37186-37187 -RRB- denotes ]
T7760 37187-37189 , denotes ,
T7761 37189-37192 CC denotes and
T7762 37193-37202 JJ denotes mammalian
T7763 37203-37209 NN denotes TRIP13
T7764 37210-37212 VBZ denotes is
T7765 37213-37217 RBR denotes more
T7766 37218-37225 JJ denotes similar
T7767 37226-37228 IN denotes to
T7768 37229-37240 NNP denotes Arabidopsis
T7769 37241-37245 NN denotes PCH2
T7770 37246-37250 IN denotes than
T7771 37251-37254 DT denotes the
T7772 37267-37275 NN denotes proteins
T7773 37255-37258 NN denotes fly
T7774 37259-37261 CC denotes or
T7775 37262-37266 NN denotes worm
T7776 37276-37277 -LRB- denotes (
T7777 37285-37287 NN denotes 1A
T7778 37277-37284 NNS denotes Figures
T7779 37288-37291 CC denotes and
T7780 37292-37294 NN denotes S1
T7781 37294-37295 -RRB- denotes )
T7782 37295-37296 . denotes .
T7783 37296-37561 sentence denotes The unusual relatedness between mammalian and plant PCH2 may therefore be attributable to both the presence of a common conserved function (namely recombination, although the role of PCH2 in plants has yet to be determined), and the absence of checkpoint function.
T7784 37297-37300 DT denotes The
T7785 37309-37320 NN denotes relatedness
T7786 37301-37308 JJ denotes unusual
T7787 37368-37370 VB denotes be
T7788 37321-37328 IN denotes between
T7789 37329-37338 JJ denotes mammalian
T7790 37349-37353 NN denotes PCH2
T7791 37339-37342 CC denotes and
T7792 37343-37348 NN denotes plant
T7793 37354-37357 MD denotes may
T7794 37358-37367 RB denotes therefore
T7795 37371-37383 JJ denotes attributable
T7796 37384-37386 IN denotes to
T7797 37387-37391 CC denotes both
T7798 37396-37404 NN denotes presence
T7799 37392-37395 DT denotes the
T7800 37405-37407 IN denotes of
T7801 37408-37409 DT denotes a
T7802 37427-37435 NN denotes function
T7803 37410-37416 JJ denotes common
T7804 37417-37426 VBN denotes conserved
T7805 37436-37437 -LRB- denotes (
T7806 37444-37457 NN denotes recombination
T7807 37437-37443 RB denotes namely
T7808 37457-37459 , denotes ,
T7809 37459-37467 IN denotes although
T7810 37495-37498 VBZ denotes has
T7811 37468-37471 DT denotes the
T7812 37472-37476 NN denotes role
T7813 37477-37479 IN denotes of
T7814 37480-37484 NN denotes PCH2
T7815 37485-37487 IN denotes in
T7816 37488-37494 NNS denotes plants
T7817 37499-37502 RB denotes yet
T7818 37509-37519 VBN denotes determined
T7819 37503-37505 TO denotes to
T7820 37506-37508 VB denotes be
T7821 37519-37520 -RRB- denotes )
T7822 37520-37522 , denotes ,
T7823 37522-37525 CC denotes and
T7824 37526-37529 DT denotes the
T7825 37530-37537 NN denotes absence
T7826 37538-37540 IN denotes of
T7827 37541-37551 NN denotes checkpoint
T7828 37552-37560 NN denotes function
T7829 37560-37561 . denotes .
T7830 37561-37811 sentence denotes Nevertheless, the evolutionary relationships between animals, fungi, and plants (which are discordant with PCH2 sequence phylogeny) do not allow parsimonious models addressing the points in time that checkpoint functions in PCH2 were gained or lost.
T7831 37562-37574 RB denotes Nevertheless
T7832 37701-37706 VB denotes allow
T7833 37574-37576 , denotes ,
T7834 37576-37579 DT denotes the
T7835 37593-37606 NNS denotes relationships
T7836 37580-37592 JJ denotes evolutionary
T7837 37607-37614 IN denotes between
T7838 37615-37622 NNS denotes animals
T7839 37622-37624 , denotes ,
T7840 37624-37629 NNS denotes fungi
T7841 37629-37631 , denotes ,
T7842 37631-37634 CC denotes and
T7843 37635-37641 NNS denotes plants
T7844 37642-37643 -LRB- denotes (
T7845 37643-37648 WDT denotes which
T7846 37649-37652 VBP denotes are
T7847 37653-37663 JJ denotes discordant
T7848 37664-37668 IN denotes with
T7849 37669-37673 NN denotes PCH2
T7850 37683-37692 NN denotes phylogeny
T7851 37674-37682 NN denotes sequence
T7852 37692-37693 -RRB- denotes )
T7853 37694-37696 VBP denotes do
T7854 37697-37700 RB denotes not
T7855 37707-37719 JJ denotes parsimonious
T7856 37720-37726 NNS denotes models
T7857 37727-37737 VBG denotes addressing
T7858 37738-37741 DT denotes the
T7859 37742-37748 NNS denotes points
T7860 37749-37751 IN denotes in
T7861 37752-37756 NN denotes time
T7862 37757-37761 IN denotes that
T7863 37796-37802 VBN denotes gained
T7864 37762-37772 NN denotes checkpoint
T7865 37773-37782 NNS denotes functions
T7866 37783-37785 IN denotes in
T7867 37786-37790 NN denotes PCH2
T7868 37791-37795 VBD denotes were
T7869 37803-37805 CC denotes or
T7870 37806-37810 VBN denotes lost
T7871 37810-37811 . denotes .
T7872 37811-37905 sentence denotes It is possible that its checkpoint function evolved independently in worms and budding yeast.
T7873 37812-37814 PRP denotes It
T7874 37815-37817 VBZ denotes is
T7875 37818-37826 JJ denotes possible
T7876 37827-37831 IN denotes that
T7877 37856-37863 VBD denotes evolved
T7878 37832-37835 PRP$ denotes its
T7879 37847-37855 NN denotes function
T7880 37836-37846 NN denotes checkpoint
T7881 37864-37877 RB denotes independently
T7882 37878-37880 IN denotes in
T7883 37881-37886 NNS denotes worms
T7884 37887-37890 CC denotes and
T7885 37891-37898 NN denotes budding
T7886 37899-37904 NN denotes yeast
T7887 37904-37905 . denotes .
T7888 37905-37995 sentence denotes The picture will become clearer as the function of PCH2 in other organisms is elucidated.
T7889 37906-37909 DT denotes The
T7890 37910-37917 NN denotes picture
T7891 37923-37929 VB denotes become
T7892 37918-37922 MD denotes will
T7893 37930-37937 JJR denotes clearer
T7894 37938-37940 IN denotes as
T7895 37984-37994 VBN denotes elucidated
T7896 37941-37944 DT denotes the
T7897 37945-37953 NN denotes function
T7898 37954-37956 IN denotes of
T7899 37957-37961 NN denotes PCH2
T7900 37962-37964 IN denotes in
T7901 37965-37970 JJ denotes other
T7902 37971-37980 NNS denotes organisms
T7903 37981-37983 VBZ denotes is
T7904 37994-37995 . denotes .
T7905 37995-38068 sentence denotes The nature of the synapsis checkpoint in male mice remains unidentified.
T7906 37996-37999 DT denotes The
T7907 38000-38006 NN denotes nature
T7908 38047-38054 VBZ denotes remains
T7909 38007-38009 IN denotes of
T7910 38010-38013 DT denotes the
T7911 38023-38033 NN denotes checkpoint
T7912 38014-38022 NN denotes synapsis
T7913 38034-38036 IN denotes in
T7914 38037-38041 JJ denotes male
T7915 38042-38046 NNS denotes mice
T7916 38055-38067 JJ denotes unidentified
T7917 38067-38068 . denotes .
T7918 38068-38327 sentence denotes One possible candidate is Dot1 (PCH1 in yeast), a histone methyltransferase silencing factor that is required for pachytene arrest of zip1 and dmc1 mutants in yeast [58], and for preventing RAD54-mediated recombinational DSB repair between sister chromatids.
T7919 38069-38072 CD denotes One
T7920 38082-38091 NN denotes candidate
T7921 38073-38081 JJ denotes possible
T7922 38092-38094 VBZ denotes is
T7923 38095-38099 NN denotes Dot1
T7924 38100-38101 -LRB- denotes (
T7925 38101-38105 NN denotes PCH1
T7926 38106-38108 IN denotes in
T7927 38109-38114 NN denotes yeast
T7928 38114-38115 -RRB- denotes )
T7929 38115-38117 , denotes ,
T7930 38117-38118 DT denotes a
T7931 38155-38161 NN denotes factor
T7932 38119-38126 NN denotes histone
T7933 38127-38144 NN denotes methyltransferase
T7934 38145-38154 NN denotes silencing
T7935 38162-38166 WDT denotes that
T7936 38170-38178 VBN denotes required
T7937 38167-38169 VBZ denotes is
T7938 38179-38182 IN denotes for
T7939 38183-38192 NN denotes pachytene
T7940 38193-38199 NN denotes arrest
T7941 38200-38202 IN denotes of
T7942 38203-38207 NN denotes zip1
T7943 38217-38224 NNS denotes mutants
T7944 38208-38211 CC denotes and
T7945 38212-38216 NN denotes dmc1
T7946 38225-38227 IN denotes in
T7947 38228-38233 NN denotes yeast
T7948 38234-38235 -LRB- denotes [
T7949 38235-38237 CD denotes 58
T7950 38237-38238 -RRB- denotes ]
T7951 38238-38240 , denotes ,
T7952 38240-38243 CC denotes and
T7953 38244-38247 IN denotes for
T7954 38248-38258 VBG denotes preventing
T7955 38259-38264 NN denotes RAD54
T7956 38265-38273 VBN denotes mediated
T7957 38264-38265 HYPH denotes -
T7958 38294-38300 NN denotes repair
T7959 38274-38289 JJ denotes recombinational
T7960 38290-38293 NN denotes DSB
T7961 38301-38308 IN denotes between
T7962 38309-38315 NN denotes sister
T7963 38316-38326 NNS denotes chromatids
T7964 38326-38327 . denotes .
T7965 38327-38364 sentence denotes However, DOT1 acts upstream of PCH2.
T7966 38328-38335 RB denotes However
T7967 38342-38346 VBZ denotes acts
T7968 38335-38337 , denotes ,
T7969 38337-38341 NN denotes DOT1
T7970 38347-38355 RB denotes upstream
T7971 38356-38358 IN denotes of
T7972 38359-38363 NN denotes PCH2
T7973 38363-38364 . denotes .
T7974 38364-38525 sentence denotes Given that TRIP13 doesn't have checkpoint function in mice, a potential role for mammalian DOT1 in the pachytene checkpoint is dubious but awaits investigation.
T7975 38365-38370 VBN denotes Given
T7976 38489-38491 VBZ denotes is
T7977 38371-38375 IN denotes that
T7978 38391-38395 VB denotes have
T7979 38376-38382 NN denotes TRIP13
T7980 38383-38387 VBZ denotes does
T7981 38387-38390 RB denotes n't
T7982 38396-38406 NN denotes checkpoint
T7983 38407-38415 NN denotes function
T7984 38416-38418 IN denotes in
T7985 38419-38423 NNS denotes mice
T7986 38423-38425 , denotes ,
T7987 38425-38426 DT denotes a
T7988 38437-38441 NN denotes role
T7989 38427-38436 JJ denotes potential
T7990 38442-38445 IN denotes for
T7991 38446-38455 JJ denotes mammalian
T7992 38456-38460 NN denotes DOT1
T7993 38461-38463 IN denotes in
T7994 38464-38467 DT denotes the
T7995 38478-38488 NN denotes checkpoint
T7996 38468-38477 NN denotes pachytene
T7997 38492-38499 JJ denotes dubious
T7998 38500-38503 CC denotes but
T7999 38504-38510 VBZ denotes awaits
T8000 38511-38524 NN denotes investigation
T8001 38524-38525 . denotes .
T8002 38525-38739 sentence denotes Recently, it was shown that the TRP53 homolog TRP63 is required for DNA damage–induced death of dictyate-stage primordial oocytes, leading to the suggestion that it is involved in monitoring genome integrity [59].
T8003 38526-38534 RB denotes Recently
T8004 38543-38548 VBN denotes shown
T8005 38534-38536 , denotes ,
T8006 38536-38538 PRP denotes it
T8007 38539-38542 VBD denotes was
T8008 38549-38553 IN denotes that
T8009 38581-38589 VBN denotes required
T8010 38554-38557 DT denotes the
T8011 38564-38571 NN denotes homolog
T8012 38558-38563 NN denotes TRP53
T8013 38572-38577 NN denotes TRP63
T8014 38578-38580 VBZ denotes is
T8015 38590-38593 IN denotes for
T8016 38594-38597 NN denotes DNA
T8017 38598-38604 NN denotes damage
T8018 38605-38612 VBN denotes induced
T8019 38604-38605 HYPH denotes –
T8020 38613-38618 NN denotes death
T8021 38619-38621 IN denotes of
T8022 38622-38630 NN denotes dictyate
T8023 38631-38636 NN denotes stage
T8024 38630-38631 HYPH denotes -
T8025 38648-38655 NNS denotes oocytes
T8026 38637-38647 JJ denotes primordial
T8027 38655-38657 , denotes ,
T8028 38657-38664 VBG denotes leading
T8029 38665-38667 IN denotes to
T8030 38668-38671 DT denotes the
T8031 38672-38682 NN denotes suggestion
T8032 38683-38687 IN denotes that
T8033 38694-38702 VBN denotes involved
T8034 38688-38690 PRP denotes it
T8035 38691-38693 VBZ denotes is
T8036 38703-38705 IN denotes in
T8037 38706-38716 VBG denotes monitoring
T8038 38717-38723 NN denotes genome
T8039 38724-38733 NN denotes integrity
T8040 38734-38735 -LRB- denotes [
T8041 38735-38737 CD denotes 59
T8042 38737-38738 -RRB- denotes ]
T8043 38738-38739 . denotes .
T8044 38739-38807 sentence denotes However, this activity occurs subsequent to a pachytene checkpoint.
T8045 38740-38747 RB denotes However
T8046 38763-38769 VBZ denotes occurs
T8047 38747-38749 , denotes ,
T8048 38749-38753 DT denotes this
T8049 38754-38762 NN denotes activity
T8050 38770-38780 RB denotes subsequent
T8051 38781-38783 IN denotes to
T8052 38784-38785 DT denotes a
T8053 38796-38806 NN denotes checkpoint
T8054 38786-38795 NN denotes pachytene
T8055 38806-38807 . denotes .
T8056 38807-39036 sentence denotes As alluded to earlier, a complicating problem for studying potential meiotic checkpoint genes in mice is that as in yeast, such genes often have mitotic functions (such as RAD24 [7]), and their ablation can cause lethality [42].
T8057 38808-38810 IN denotes As
T8058 38811-38818 VBN denotes alluded
T8059 38910-38912 VBZ denotes is
T8060 38819-38821 IN denotes to
T8061 38822-38829 RBR denotes earlier
T8062 38829-38831 , denotes ,
T8063 38831-38832 DT denotes a
T8064 38846-38853 NN denotes problem
T8065 38833-38845 VBG denotes complicating
T8066 38854-38857 IN denotes for
T8067 38858-38866 VBG denotes studying
T8068 38867-38876 JJ denotes potential
T8069 38885-38895 NN denotes checkpoint
T8070 38877-38884 JJ denotes meiotic
T8071 38896-38901 NNS denotes genes
T8072 38902-38904 IN denotes in
T8073 38905-38909 NNS denotes mice
T8074 38913-38917 IN denotes that
T8075 38948-38952 VBP denotes have
T8076 38918-38920 IN denotes as
T8115 39114-39123 NNS denotes functions
T8116 39124-39126 IN denotes in
T8117 39127-39136 NNS denotes organisms
T8118 39137-39141 JJ denotes such
T8119 39142-39144 IN denotes as
T8120 39145-39150 NN denotes yeast
T8121 39150-39152 , denotes ,
T8122 39152-39157 PRP$ denotes their
T8123 39158-39168 NNS denotes identities
T8124 39173-39179 JJ denotes likely
T8125 39180-39182 TO denotes to
T8126 39183-39189 VB denotes remain
T8127 39190-39197 JJ denotes elusive
T8128 39197-39198 . denotes .
T8150 39223-39226 NN denotes PCR
T8151 39227-39235 NN denotes analysis
T8152 39236-39238 IN denotes of
T8153 39239-39245 NN denotes Trip13
T8154 39246-39250 NN denotes cDNA
T8155 39250-39251 . denotes .
T8156 39251-39469 sentence denotes Trip13 was amplified from samples of Clontech's Mouse Multiple Tissue cDNA Panel I (http://www.clontech.com), using the following primers: 5′-GCACCATTGCACTTCACATC-3′ (TRP3-6F) and 5′-TGACCATCAGACTGTCGAGC-3′ (TRP3-6R).
T8157 39252-39258 NN denotes Trip13
T8158 39263-39272 VBN denotes amplified
T8159 39259-39262 VBD denotes was
T8160 39273-39277 IN denotes from
T8161 39278-39285 NNS denotes samples
T8162 39286-39288 IN denotes of
T8163 39289-39297 NNP denotes Clontech
T8164 39327-39332 NN denotes Panel
T8165 39297-39299 POS denotes 's
T8166 39300-39305 NN denotes Mouse
T8167 39306-39314 JJ denotes Multiple
T8168 39315-39321 NN denotes Tissue
T8169 39322-39326 NN denotes cDNA
T8170 39333-39334 CD denotes I
T8171 39335-39336 -LRB- denotes (
T8172 39336-39359 NN denotes http://www.clontech.com
T8173 39359-39360 -RRB- denotes )
T8174 39360-39362 , denotes ,
T8175 39362-39367 VBG denotes using
T8176 39368-39371 DT denotes the
T8177 39382-39389 NNS denotes primers
T8178 39372-39381 VBG denotes following
T8179 39389-39391 : denotes :
T8180 39391-39392 CD denotes 5
T8181 39394-39414 NN denotes GCACCATTGCACTTCACATC
T8182 39392-39393 SYM denotes ′
T8183 39393-39394 HYPH denotes -
T8184 39414-39415 HYPH denotes -
T8185 39415-39416 CD denotes 3
T8186 39416-39417 SYM denotes ′
T8187 39418-39419 -LRB- denotes (
T8188 39419-39423 NN denotes TRP3
T8189 39424-39426 NN denotes 6F
T8190 39423-39424 HYPH denotes -
T8191 39426-39427 -RRB- denotes )
T8192 39428-39431 CC denotes and
T8193 39432-39433 CD denotes 5
T8194 39435-39455 NN denotes TGACCATCAGACTGTCGAGC
T8195 39433-39434 SYM denotes ′
T8196 39434-39435 HYPH denotes -
T8197 39455-39456 HYPH denotes -
T8198 39456-39457 CD denotes 3
T8199 39457-39458 SYM denotes ′
T8200 39459-39460 -LRB- denotes (
T8201 39460-39464 NN denotes TRP3
T8202 39465-39467 NN denotes 6R
T8203 39464-39465 HYPH denotes -
T8204 39467-39468 -RRB- denotes )
T8205 39468-39469 . denotes .
T8206 39469-39561 sentence denotes These primers correspond to exons 3 and 6, respectively, and amplify a 330-bp cDNA product.
T8207 39470-39475 DT denotes These
T8208 39476-39483 NNS denotes primers
T8209 39484-39494 VBP denotes correspond
T8210 39495-39497 IN denotes to
T8211 39498-39503 NNS denotes exons
T8212 39504-39505 CD denotes 3
T8213 39506-39509 CC denotes and
T8214 39510-39511 CD denotes 6
T8215 39511-39513 , denotes ,
T8216 39513-39525 RB denotes respectively
T8217 39525-39527 , denotes ,
T8218 39527-39530 CC denotes and
T8219 39531-39538 VB denotes amplify
T8220 39539-39540 DT denotes a
T8221 39553-39560 NN denotes product
T8222 39541-39544 CD denotes 330
T8223 39545-39547 NN denotes bp
T8224 39544-39545 HYPH denotes -
T8225 39548-39552 NN denotes cDNA
T8226 39560-39561 . denotes .
T8227 39561-39641 sentence denotes The cDNAs in this panel are equalized to allow quantitative analysis by RT-PCR.
T8228 39562-39565 DT denotes The
T8229 39566-39571 NNS denotes cDNAs
T8230 39590-39599 VBN denotes equalized
T8231 39572-39574 IN denotes in
T8232 39575-39579 DT denotes this
T8233 39580-39585 NN denotes panel
T8234 39586-39589 VBP denotes are
T8235 39600-39602 TO denotes to
T8236 39603-39608 VB denotes allow
T8237 39609-39621 JJ denotes quantitative
T8238 39622-39630 NN denotes analysis
T8239 39631-39633 IN denotes by
T8240 39634-39636 NN denotes RT
T8241 39637-39640 NN denotes PCR
T8242 39636-39637 HYPH denotes -
T8243 39640-39641 . denotes .
T8308 39643-39653 NN denotes Generation
T8309 39654-39656 IN denotes of
T8310 39657-39663 NN denotes Trip13
T8311 39664-39673 JJ denotes deficient
T8312 39663-39664 HYPH denotes -
T8313 39674-39678 NNS denotes mice
T8314 39678-39679 . denotes .
T8315 39679-39847 sentence denotes The mouse embryonic stem cell line RRB047 (strain 129/Ola) containing a gene trap insertion in Trip13 was obtained from BayGenomics (http://www.baygenomics.ucsf.edu/).
T8316 39680-39683 DT denotes The
T8317 39715-39721 NN denotes RRB047
T8318 39684-39689 NN denotes mouse
T8319 39690-39699 JJ denotes embryonic
T8320 39700-39704 NN denotes stem
T8321 39705-39709 NN denotes cell
T8322 39710-39714 NN denotes line
T8323 39786-39794 VBN denotes obtained
T8324 39722-39723 -LRB- denotes (
T8325 39723-39729 NN denotes strain
T8326 39734-39737 NN denotes Ola
T8327 39730-39733 CD denotes 129
T8328 39733-39734 HYPH denotes /
T8329 39737-39738 -RRB- denotes )
T8330 39739-39749 VBG denotes containing
T8331 39750-39751 DT denotes a
T8332 39762-39771 NN denotes insertion
T8333 39752-39756 NN denotes gene
T8334 39757-39761 NN denotes trap
T8335 39772-39774 IN denotes in
T8336 39775-39781 NN denotes Trip13
T8337 39782-39785 VBD denotes was
T8338 39795-39799 IN denotes from
T8339 39800-39811 NNP denotes BayGenomics
T8340 39812-39813 -LRB- denotes (
T8341 39813-39845 NN denotes http://www.baygenomics.ucsf.edu/
T8342 39845-39846 -RRB- denotes )
T8343 39846-39847 . denotes .
T8344 39847-40077 sentence denotes The gene-trapping vector used to create this line, pGT1lxf, was designed to create an in-frame fusion between the 5′ exons of the trapped gene and a reporter, βgeo (a fusion of β-galactosidase and neomycin phosphotransferase II).
T8345 39848-39851 DT denotes The
T8346 39866-39872 NN denotes vector
T8347 39852-39856 NN denotes gene
T8348 39856-39857 HYPH denotes -
T8349 39857-39865 VBG denotes trapping
T8350 39912-39920 VBN denotes designed
T8351 39873-39877 VBN denotes used
T8352 39878-39880 TO denotes to
T8353 39881-39887 VB denotes create
T8354 39888-39892 DT denotes this
T8355 39893-39897 NN denotes line
T8356 39897-39899 , denotes ,
T8357 39899-39906 NN denotes pGT1lxf
T8358 39906-39908 , denotes ,
T8359 39908-39911 VBD denotes was
T8360 39921-39923 TO denotes to
T8361 39924-39930 VB denotes create
T8362 39931-39933 DT denotes an
T8363 39943-39949 NN denotes fusion
T8364 39934-39936 IN denotes in
T8365 39936-39937 HYPH denotes -
T8366 39937-39942 NN denotes frame
T8367 39950-39957 IN denotes between
T8368 39958-39961 DT denotes the
T8369 39965-39970 NNS denotes exons
T8370 39962-39963 CD denotes 5
T8371 39963-39964 SYM denotes ′
T8372 39971-39973 IN denotes of
T8373 39974-39977 DT denotes the
T8374 39986-39990 NN denotes gene
T8375 39978-39985 VBN denotes trapped
T8376 39991-39994 CC denotes and
T8377 39995-39996 DT denotes a
T8378 39997-40005 NN denotes reporter
T8379 40005-40007 , denotes ,
T8380 40007-40011 NN denotes βgeo
T8381 40012-40013 -LRB- denotes (
T8382 40013-40014 DT denotes a
T8383 40015-40021 NN denotes fusion
T8384 40022-40024 IN denotes of
T8385 40025-40026 NN denotes β
T8386 40027-40040 NN denotes galactosidase
T8387 40026-40027 HYPH denotes -
T8388 40041-40044 CC denotes and
T8389 40045-40053 NN denotes neomycin
T8390 40054-40072 NN denotes phosphotransferase
T8391 40073-40075 CD denotes II
T8392 40075-40076 -RRB- denotes )
T8393 40076-40077 . denotes .
T8394 40077-40169 sentence denotes The gene-trapped locus creates a fusion transcript containing exons 1–3 of Trip13 and βgeo.
T8395 40078-40081 DT denotes The
T8396 40095-40100 NN denotes locus
T8397 40082-40086 NN denotes gene
T8398 40087-40094 VBN denotes trapped
T8399 40086-40087 HYPH denotes -
T8400 40101-40108 VBZ denotes creates
T8401 40109-40110 DT denotes a
T8402 40118-40128 NN denotes transcript
T8403 40111-40117 NN denotes fusion
T8404 40129-40139 VBG denotes containing
T8405 40140-40145 NNS denotes exons
T8406 40148-40149 CD denotes 3
T8407 40146-40147 CD denotes 1
T8408 40147-40148 SYM denotes –
T8409 40150-40152 IN denotes of
T8410 40153-40159 NN denotes Trip13
T8411 40160-40163 CC denotes and
T8412 40164-40168 NN denotes βgeo
T8413 40168-40169 . denotes .
T8414 40169-40382 sentence denotes To identify the exact insertion site within intron 3, PCR was performed using one primer within the gene trap vector, and the other primer at various positions in intron 3 pointing towards the 3′ end of the gene.
T8415 40170-40172 TO denotes To
T8416 40173-40181 VB denotes identify
T8417 40232-40241 VBN denotes performed
T8418 40182-40185 DT denotes the
T8419 40202-40206 NN denotes site
T8420 40186-40191 JJ denotes exact
T8421 40192-40201 NN denotes insertion
T8422 40207-40213 IN denotes within
T8423 40214-40220 NN denotes intron
T8424 40221-40222 CD denotes 3
T8425 40222-40224 , denotes ,
T8426 40224-40227 NN denotes PCR
T8427 40228-40231 VBD denotes was
T8428 40242-40247 VBG denotes using
T8429 40248-40251 CD denotes one
T8430 40252-40258 NN denotes primer
T8431 40259-40265 IN denotes within
T8432 40266-40269 DT denotes the
T8433 40280-40286 NN denotes vector
T8434 40270-40274 NN denotes gene
T8435 40275-40279 NN denotes trap
T8436 40286-40288 , denotes ,
T8437 40288-40291 CC denotes and
T8438 40292-40295 DT denotes the
T8439 40302-40308 NN denotes primer
T8440 40296-40301 JJ denotes other
T8441 40309-40311 IN denotes at
T8442 40312-40319 JJ denotes various
T8443 40320-40329 NNS denotes positions
T8444 40330-40332 IN denotes in
T8445 40333-40339 NN denotes intron
T8446 40340-40341 CD denotes 3
T8447 40342-40350 VBG denotes pointing
T8448 40351-40358 IN denotes towards
T8449 40359-40362 DT denotes the
T8450 40366-40369 NN denotes end
T8451 40363-40364 CD denotes 3
T8452 40364-40365 SYM denotes ′
T8453 40370-40372 IN denotes of
T8454 40373-40376 DT denotes the
T8455 40377-40381 NN denotes gene
T8456 40381-40382 . denotes .
T8457 40382-40492 sentence denotes Product from a productive reaction was sequenced, revealing that the insertion site was 445 bp into intron 3.
T8458 40383-40390 NN denotes Product
T8459 40422-40431 VBN denotes sequenced
T8460 40391-40395 IN denotes from
T8461 40396-40397 DT denotes a
T8462 40409-40417 NN denotes reaction
T8463 40398-40408 JJ denotes productive
T8464 40418-40421 VBD denotes was
T8465 40431-40433 , denotes ,
T8466 40433-40442 VBG denotes revealing
T8467 40443-40447 IN denotes that
T8468 40467-40470 VBD denotes was
T8469 40448-40451 DT denotes the
T8470 40462-40466 NN denotes site
T8471 40452-40461 NN denotes insertion
T8472 40471-40474 CD denotes 445
T8473 40475-40477 NN denotes bp
T8474 40478-40482 IN denotes into
T8475 40483-40489 NN denotes intron
T8476 40490-40491 CD denotes 3
T8477 40491-40492 . denotes .
T8521 40494-40504 NN denotes Genotyping
T8522 40505-40507 IN denotes of
T8523 40508-40512 NNS denotes mice
T8524 40512-40513 . denotes .
T8525 40513-40727 sentence denotes Three primers were used to distinguish wild-type and mutant alleles of Trip13: primer 1, 5′-CGTCGCTCCATTGCTTTGTGC-3′; primer 2, 5′-AGTAGTGGTACACTGTATTTTTGCTTTCATTGA-3′; and primer 3, 5′-GTAGATCCCGGCGCTCTTACCAA-3′.
T8526 40514-40519 CD denotes Three
T8527 40520-40527 NNS denotes primers
T8528 40533-40537 VBN denotes used
T8529 40528-40532 VBD denotes were
T8530 40538-40540 TO denotes to
T8531 40541-40552 VB denotes distinguish
T8532 40553-40557 JJ denotes wild
T8533 40558-40562 NN denotes type
T8534 40557-40558 HYPH denotes -
T8535 40574-40581 NNS denotes alleles
T8536 40563-40566 CC denotes and
T8537 40567-40573 NN denotes mutant
T8538 40582-40584 IN denotes of
T8539 40585-40591 NN denotes Trip13
T8540 40591-40593 : denotes :
T8541 40593-40599 NN denotes primer
T8542 40600-40601 CD denotes 1
T8543 40601-40603 , denotes ,
T8544 40603-40604 CD denotes 5
T8545 40606-40627 NN denotes CGTCGCTCCATTGCTTTGTGC
T8546 40604-40605 SYM denotes ′
T8547 40605-40606 HYPH denotes -
T8548 40627-40628 HYPH denotes -
T8549 40628-40629 CD denotes 3
T8550 40629-40630 SYM denotes ′
T8551 40630-40631 : denotes ;
T8552 40632-40638 NN denotes primer
T8553 40639-40640 CD denotes 2
T8554 40640-40642 , denotes ,
T8555 40642-40643 CD denotes 5
T8556 40645-40678 NN denotes AGTAGTGGTACACTGTATTTTTGCTTTCATTGA
T8557 40643-40644 SYM denotes ′
T8558 40644-40645 HYPH denotes -
T8559 40678-40679 HYPH denotes -
T8560 40679-40680 CD denotes 3
T8561 40680-40681 SYM denotes ′
T8562 40681-40682 : denotes ;
T8563 40683-40686 CC denotes and
T8564 40687-40693 NN denotes primer
T8565 40694-40695 CD denotes 3
T8566 40695-40697 , denotes ,
T8567 40697-40698 CD denotes 5
T8568 40700-40723 NN denotes GTAGATCCCGGCGCTCTTACCAA
T8569 40698-40699 SYM denotes ′
T8570 40699-40700 HYPH denotes -
T8571 40723-40724 HYPH denotes -
T8572 40724-40725 CD denotes 3
T8573 40725-40726 SYM denotes ′
T8574 40726-40727 . denotes .
T8575 40727-40842 sentence denotes Primers 1 and 2 are located upstream and downstream, respectively, of the gene trap insertion within the intron 3.
T8576 40728-40735 NNS denotes Primers
T8577 40736-40737 CD denotes 1
T8578 40748-40755 VBN denotes located
T8579 40738-40741 CC denotes and
T8580 40742-40743 CD denotes 2
T8581 40744-40747 VBP denotes are
T8582 40756-40764 RB denotes upstream
T8583 40765-40768 CC denotes and
T8584 40769-40779 RB denotes downstream
T8585 40779-40781 , denotes ,
T8586 40781-40793 RB denotes respectively
T8587 40793-40795 , denotes ,
T8588 40795-40797 IN denotes of
T8589 40798-40801 DT denotes the
T8590 40812-40821 NN denotes insertion
T8591 40802-40806 NN denotes gene
T8592 40807-40811 NN denotes trap
T8593 40822-40828 IN denotes within
T8594 40829-40832 DT denotes the
T8595 40833-40839 NN denotes intron
T8596 40840-40841 CD denotes 3
T8597 40841-40842 . denotes .
T8598 40842-40883 sentence denotes Primer 3 corresponds to pGTlxf sequence.
T8599 40843-40849 NN denotes Primer
T8600 40852-40863 VBZ denotes corresponds
T8601 40850-40851 CD denotes 3
T8602 40864-40866 IN denotes to
T8603 40867-40873 NN denotes pGTlxf
T8604 40874-40882 NN denotes sequence
T8605 40882-40883 . denotes .
T8606 40883-41010 sentence denotes Primers 1 and 2 amplify a 700-bp band from a wild-type allele; primers 1 and 3 amplify a 540-bp fragment from a mutant allele.
T8607 40884-40891 NNS denotes Primers
T8608 40892-40893 CD denotes 1
T8609 40900-40907 VBP denotes amplify
T8610 40894-40897 CC denotes and
T8611 40898-40899 CD denotes 2
T8612 40963-40970 VBP denotes amplify
T8613 40908-40909 DT denotes a
T8614 40917-40921 NN denotes band
T8615 40910-40913 CD denotes 700
T8616 40914-40916 NN denotes bp
T8617 40913-40914 HYPH denotes -
T8618 40922-40926 IN denotes from
T8619 40927-40928 DT denotes a
T8620 40939-40945 NN denotes allele
T8621 40929-40933 JJ denotes wild
T8622 40934-40938 NN denotes type
T8623 40933-40934 HYPH denotes -
T8624 40945-40946 : denotes ;
T8625 40947-40954 NNS denotes primers
T8626 40955-40956 CD denotes 1
T8627 40957-40960 CC denotes and
T8628 40961-40962 CD denotes 3
T8629 40971-40972 DT denotes a
T8630 40980-40988 NN denotes fragment
T8631 40973-40976 CD denotes 540
T8632 40977-40979 NN denotes bp
T8633 40976-40977 HYPH denotes -
T8634 40989-40993 IN denotes from
T8635 40994-40995 DT denotes a
T8636 41003-41009 NN denotes allele
T8637 40996-41002 NN denotes mutant
T8638 41009-41010 . denotes .
T8639 41010-41108 sentence denotes Separate reactions were used to assay the presence or absence of each amplicon from a DNA sample.
T8640 41011-41019 JJ denotes Separate
T8641 41020-41029 NNS denotes reactions
T8642 41035-41039 VBN denotes used
T8643 41030-41034 VBD denotes were
T8644 41040-41042 TO denotes to
T8645 41043-41048 VB denotes assay
T8646 41049-41052 DT denotes the
T8647 41053-41061 NN denotes presence
T8648 41062-41064 CC denotes or
T8649 41065-41072 NN denotes absence
T8650 41073-41075 IN denotes of
T8651 41076-41080 DT denotes each
T8652 41081-41089 NN denotes amplicon
T8653 41090-41094 IN denotes from
T8654 41095-41096 DT denotes a
T8655 41101-41107 NN denotes sample
T8656 41097-41100 NN denotes DNA
T8657 41107-41108 . denotes .
T8658 41108-41219 sentence denotes The cycling conditions were: 94 °C 2 min; 35 cycles of 94 °C 30 s, 57 °C 45 s, and 72°C 50 s; and 72 °C 2 min.
T8659 41109-41112 DT denotes The
T8660 41121-41131 NNS denotes conditions
T8661 41113-41120 NN denotes cycling
T8662 41132-41136 VBD denotes were
T8663 41136-41138 : denotes :
T8664 41138-41140 CD denotes 94
T8665 41141-41143 NN denotes °C
T8666 41144-41145 CD denotes 2
T8667 41146-41149 NN denotes min
T8668 41149-41150 : denotes ;
T8669 41151-41153 CD denotes 35
T8670 41154-41160 NNS denotes cycles
T8671 41161-41163 IN denotes of
T8672 41164-41166 CD denotes 94
T8673 41167-41169 NN denotes °C
T8674 41170-41172 CD denotes 30
T8675 41173-41174 NN denotes s
T8676 41174-41176 , denotes ,
T8677 41176-41178 CD denotes 57
T8678 41179-41181 NN denotes °C
T8679 41182-41184 CD denotes 45
T8680 41185-41186 NN denotes s
T8681 41186-41188 , denotes ,
T8682 41188-41191 CC denotes and
T8683 41192-41194 CD denotes 72
T8684 41194-41196 NN denotes °C
T8685 41197-41199 CD denotes 50
T8686 41200-41201 NN denotes s
T8687 41201-41202 : denotes ;
T8688 41203-41206 CC denotes and
T8689 41207-41209 CD denotes 72
T8690 41210-41212 NN denotes °C
T8691 41213-41214 CD denotes 2
T8692 41215-41218 NN denotes min
T8693 41218-41219 . denotes .
T8793 41590-41594 VBD denotes were
T8717 41221-41223 NN denotes RT
T8718 41224-41227 NN denotes PCR
T8719 41223-41224 HYPH denotes -
T8720 41227-41228 . denotes .
T8721 41228-41443 sentence denotes Total RNA was isolated from adult testes with the RNeasy Mini Kit (Qiagen, http://www.qiagen.com), and 4.0 μg was oligo dT–primed and reverse-transcribed with Superscript II (Stratagene, http://www.stratagene.com).
T8722 41229-41234 JJ denotes Total
T8723 41235-41238 NN denotes RNA
T8724 41243-41251 VBN denotes isolated
T8725 41239-41242 VBD denotes was
T8726 41252-41256 IN denotes from
T8727 41257-41262 JJ denotes adult
T8728 41263-41269 NNS denotes testes
T8729 41270-41274 IN denotes with
T8730 41275-41278 DT denotes the
T8731 41291-41294 NNP denotes Kit
T8732 41279-41285 NNP denotes RNeasy
T8733 41286-41290 NNP denotes Mini
T8734 41295-41296 -LRB- denotes (
T8735 41296-41302 NNP denotes Qiagen
T8736 41302-41304 , denotes ,
T8737 41304-41325 NN denotes http://www.qiagen.com
T8738 41325-41326 -RRB- denotes )
T8739 41326-41328 , denotes ,
T8740 41328-41331 CC denotes and
T8741 41332-41335 CD denotes 4.0
T8742 41336-41338 NN denotes μg
T8743 41352-41358 VBN denotes primed
T8744 41339-41342 VBD denotes was
T8745 41343-41348 NN denotes oligo
T8746 41349-41351 NN denotes dT
T8747 41351-41352 HYPH denotes –
T8748 41359-41362 CC denotes and
T8749 41363-41370 RB denotes reverse
T8750 41371-41382 VBN denotes transcribed
T8751 41370-41371 HYPH denotes -
T8752 41383-41387 IN denotes with
T8753 41388-41399 NNP denotes Superscript
T8754 41400-41402 CD denotes II
T8755 41403-41404 -LRB- denotes (
T8756 41404-41414 NNP denotes Stratagene
T8757 41414-41416 , denotes ,
T8758 41416-41441 NN denotes http://www.stratagene.com
T8759 41441-41442 -RRB- denotes )
T8760 41442-41443 . denotes .
T8761 41443-41566 sentence denotes The entire Trip13 protein-coding sequence was amplified with primers 5′-ATGGACGAGGCGGTG-3′ and 5′-TCAAACATAAGCTGAAAGTT-3′.
T8762 41444-41447 DT denotes The
T8763 41477-41485 NN denotes sequence
T8764 41448-41454 JJ denotes entire
T8765 41455-41461 NN denotes Trip13
T8766 41462-41469 NN denotes protein
T8767 41470-41476 VBG denotes coding
T8768 41469-41470 HYPH denotes -
T8769 41490-41499 VBN denotes amplified
T8770 41486-41489 VBD denotes was
T8771 41500-41504 IN denotes with
T8772 41505-41512 NNS denotes primers
T8773 41516-41531 NN denotes ATGGACGAGGCGGTG
T8774 41513-41514 CD denotes 5
T8775 41514-41515 SYM denotes ′
T8776 41515-41516 HYPH denotes -
T8777 41531-41532 HYPH denotes -
T8778 41532-41533 CD denotes 3
T8779 41533-41534 SYM denotes ′
T8780 41535-41538 CC denotes and
T8781 41539-41540 CD denotes 5
T8782 41542-41562 NN denotes TCAAACATAAGCTGAAAGTT
T8783 41540-41541 SYM denotes ′
T8784 41541-41542 HYPH denotes -
T8785 41562-41563 HYPH denotes -
T8786 41563-41564 CD denotes 3
T8787 41564-41565 SYM denotes ′
T8788 41565-41566 . denotes .
T8789 41566-41678 sentence denotes The cycling conditions were: 94 °C 2 min; 94 °C 30s, 55 °C 45 s, and 72 °C 80 s for 35 cycles; and 72 °C 2 min.
T8790 41567-41570 DT denotes The
T8791 41579-41589 NNS denotes conditions
T8792 41571-41578 NN denotes cycling
T8794 41594-41596 : denotes :
T8795 41596-41598 CD denotes 94
T8796 41599-41601 NN denotes °C
T8797 41602-41603 CD denotes 2
T8798 41604-41607 NN denotes min
T8799 41607-41608 : denotes ;
T8800 41609-41611 CD denotes 94
T8801 41612-41614 NN denotes °C
T8802 41615-41617 CD denotes 30
T8803 41617-41618 NN denotes s
T8804 41618-41620 , denotes ,
T8805 41620-41622 CD denotes 55
T8806 41623-41625 NN denotes °C
T8807 41626-41628 CD denotes 45
T8808 41629-41630 NN denotes s
T8809 41630-41632 , denotes ,
T8810 41632-41635 CC denotes and
T8811 41636-41638 CD denotes 72
T8812 41639-41641 NN denotes °C
T8813 41642-41644 CD denotes 80
T8814 41645-41646 NN denotes s
T8815 41647-41650 IN denotes for
T8816 41651-41653 CD denotes 35
T8817 41654-41660 NNS denotes cycles
T8818 41660-41661 : denotes ;
T8819 41662-41665 CC denotes and
T8820 41666-41668 CD denotes 72
T8821 41669-41671 NN denotes °C
T8822 41672-41673 CD denotes 2
T8823 41674-41677 NN denotes min
T8824 41677-41678 . denotes .
T8825 41678-41824 sentence denotes The primers for amplifying the Med31 coding sequence as control were : 5′-ATGGCCGCGGCCGTCGCTATGG-3′ and 5′-TCATTTCCCTGCTGTGTTATTCTGCTGCTGCTGC-3′.
T8826 41679-41682 DT denotes The
T8827 41683-41690 NNS denotes primers
T8828 41743-41747 VBD denotes were
T8829 41691-41694 IN denotes for
T8830 41695-41705 VBG denotes amplifying
T8831 41706-41709 DT denotes the
T8832 41723-41731 NN denotes sequence
T8833 41710-41715 NN denotes Med31
T8834 41716-41722 NN denotes coding
T8835 41732-41734 IN denotes as
T8836 41735-41742 NN denotes control
T8837 41748-41750 : denotes :
T8838 41750-41751 CD denotes 5
T8839 41753-41775 NN denotes ATGGCCGCGGCCGTCGCTATGG
T8840 41751-41752 SYM denotes ′
T8841 41752-41753 HYPH denotes -
T8842 41775-41776 HYPH denotes -
T8843 41776-41777 CD denotes 3
T8844 41777-41778 SYM denotes ′
T8845 41779-41782 CC denotes and
T8846 41783-41784 CD denotes 5
T8847 41786-41820 NN denotes TCATTTCCCTGCTGTGTTATTCTGCTGCTGCTGC
T8848 41784-41785 SYM denotes ′
T8849 41785-41786 HYPH denotes -
T8850 41820-41821 HYPH denotes -
T8851 41821-41822 CD denotes 3
T8852 41822-41823 SYM denotes ′
T8853 41823-41824 . denotes .
T8854 41824-41937 sentence denotes The cycling conditions were: 94 °C 2 min; 94 °C 30 s, 55 °C 30 s, and 72 °C 35 s for 35 cycles; and 72 °C 2 min.
T8855 41825-41828 DT denotes The
T8856 41837-41847 NNS denotes conditions
T8857 41829-41836 NN denotes cycling
T8858 41848-41852 VBD denotes were
T8859 41852-41854 : denotes :
T8860 41854-41856 CD denotes 94
T8861 41857-41859 NN denotes °C
T8862 41860-41861 CD denotes 2
T8863 41862-41865 NN denotes min
T8864 41865-41866 : denotes ;
T8865 41867-41869 CD denotes 94
T8866 41870-41872 NN denotes °C
T8867 41873-41875 CD denotes 30
T8868 41876-41877 NN denotes s
T8869 41877-41879 , denotes ,
T8870 41879-41881 CD denotes 55
T8871 41882-41884 NN denotes °C
T8872 41885-41887 CD denotes 30
T8873 41888-41889 NN denotes s
T8874 41889-41891 , denotes ,
T8875 41891-41894 CC denotes and
T8876 41895-41897 CD denotes 72
T8877 41898-41900 NN denotes °C
T8878 41901-41903 CD denotes 35
T8879 41904-41905 NN denotes s
T8880 41906-41909 IN denotes for
T8881 41910-41912 CD denotes 35
T8882 41913-41919 NNS denotes cycles
T8883 41919-41920 : denotes ;
T8884 41921-41924 CC denotes and
T8885 41925-41927 CD denotes 72
T8886 41928-41930 NN denotes °C
T8887 41931-41932 CD denotes 2
T8888 41933-41936 NN denotes min
T8889 41936-41937 . denotes .
T8918 41939-41950 NN denotes Development
T8919 41951-41954 CC denotes and
T8920 41955-41967 NN denotes purification
T8921 41968-41970 IN denotes of
T8922 41971-41978 NN denotes chicken
T8923 41979-41989 NNS denotes antibodies
T8924 41989-41990 . denotes .
T8925 41990-42169 sentence denotes A peptide corresponding to amino acids 25–40 of TRIP13, VLQRSGSTAKKEDIK, was conjugated to KLH and used to immunize chickens (done by Sigma Genosys, http://www.sigmaaldrich.com).
T8926 41991-41992 DT denotes A
T8927 41993-42000 NN denotes peptide
T8928 42068-42078 VBN denotes conjugated
T8929 42001-42014 VBG denotes corresponding
T8930 42015-42017 IN denotes to
T8931 42018-42023 NN denotes amino
T8932 42030-42032 CD denotes 25
T8933 42024-42029 NNS denotes acids
T8934 42032-42033 SYM denotes –
T8935 42033-42035 CD denotes 40
T8936 42036-42038 IN denotes of
T8937 42039-42045 NN denotes TRIP13
T8938 42045-42047 , denotes ,
T8939 42047-42062 NN denotes VLQRSGSTAKKEDIK
T8940 42062-42064 , denotes ,
T8941 42064-42067 VBD denotes was
T8942 42079-42081 IN denotes to
T8943 42082-42085 NN denotes KLH
T8944 42086-42089 CC denotes and
T8945 42090-42094 VBN denotes used
T8946 42095-42097 TO denotes to
T8947 42098-42106 VB denotes immunize
T8948 42107-42115 NNS denotes chickens
T8949 42116-42117 -LRB- denotes (
T8950 42117-42121 VBN denotes done
T8951 42122-42124 IN denotes by
T8952 42125-42130 NNP denotes Sigma
T8953 42131-42138 NNP denotes Genosys
T8954 42138-42140 , denotes ,
T8955 42140-42167 NN denotes http://www.sigmaaldrich.com
T8956 42167-42168 -RRB- denotes )
T8957 42168-42169 . denotes .
T8958 42169-42292 sentence denotes Polyclonal IgY was isolated from eggs with the Eggcellent Chicken IgY Purification kit (Pierce, http://www.piercenet.com).
T8959 42170-42180 JJ denotes Polyclonal
T8960 42181-42184 NN denotes IgY
T8961 42189-42197 VBN denotes isolated
T8962 42185-42188 VBD denotes was
T8963 42198-42202 IN denotes from
T8964 42203-42207 NNS denotes eggs
T8965 42208-42212 IN denotes with
T8966 42213-42216 DT denotes the
T8967 42253-42256 NN denotes kit
T8968 42217-42227 NNP denotes Eggcellent
T8969 42228-42235 NNP denotes Chicken
T8970 42236-42239 NNP denotes IgY
T8971 42240-42252 NNP denotes Purification
T8972 42257-42258 -LRB- denotes (
T8973 42258-42264 NNP denotes Pierce
T8974 42264-42266 , denotes ,
T8975 42266-42290 NN denotes http://www.piercenet.com
T8976 42290-42291 -RRB- denotes )
T8977 42291-42292 . denotes .
T8978 42292-42375 sentence denotes IgY antibodies were then affinity purified using the immunizing synthetic peptide.
T8979 42293-42296 NN denotes IgY
T8980 42297-42307 NNS denotes antibodies
T8981 42327-42335 VBN denotes purified
T8982 42308-42312 VBD denotes were
T8983 42313-42317 RB denotes then
T8984 42318-42326 NN denotes affinity
T8985 42336-42341 VBG denotes using
T8986 42342-42345 DT denotes the
T8987 42367-42374 NN denotes peptide
T8988 42346-42356 VBG denotes immunizing
T8989 42357-42366 JJ denotes synthetic
T8990 42374-42375 . denotes .
T9024 42377-42384 NNP denotes Western
T9025 42385-42393 NN denotes blotting
T9026 42393-42394 . denotes .
T9027 42394-42555 sentence denotes 50 μg of testis extract in RIPA buffer was separated by 8% SDS-PAGE and electrotransferred onto a Pure Nitrocellulose membrane (Bio-Rad, http://www.biorad.com).
T9028 42395-42397 CD denotes 50
T9029 42398-42400 NN denotes μg
T9030 42438-42447 VBN denotes separated
T9031 42401-42403 IN denotes of
T9032 42404-42410 NN denotes testis
T9033 42411-42418 NN denotes extract
T9034 42419-42421 IN denotes in
T9035 42422-42426 NN denotes RIPA
T9036 42427-42433 NN denotes buffer
T9037 42434-42437 VBD denotes was
T9038 42448-42450 IN denotes by
T9039 42451-42452 CD denotes 8
T9040 42452-42453 NN denotes %
T9041 42458-42462 NN denotes PAGE
T9042 42454-42457 NN denotes SDS
T9043 42457-42458 HYPH denotes -
T9044 42463-42466 CC denotes and
T9045 42467-42485 VBD denotes electrotransferred
T9046 42486-42490 IN denotes onto
T9047 42491-42492 DT denotes a
T9048 42513-42521 NN denotes membrane
T9049 42493-42497 NNP denotes Pure
T9050 42498-42512 NNP denotes Nitrocellulose
T9051 42522-42523 -LRB- denotes (
T9052 42527-42530 NNP denotes Rad
T9053 42523-42526 NNP denotes Bio
T9054 42526-42527 HYPH denotes -
T9055 42530-42532 , denotes ,
T9056 42532-42553 NN denotes http://www.biorad.com
T9057 42553-42554 -RRB- denotes )
T9058 42554-42555 . denotes .
T9059 42555-42684 sentence denotes The membrane was incubated with a polyclonal rabbit anti-human TRIP13 antibody (18-003-42687; Genway, http://www.genwaybio.com).
T9060 42556-42559 DT denotes The
T9061 42560-42568 NN denotes membrane
T9062 42573-42582 VBN denotes incubated
T9063 42569-42572 VBD denotes was
T9064 42583-42587 IN denotes with
T9065 42588-42589 DT denotes a
T9066 42626-42634 NN denotes antibody
T9067 42590-42600 JJ denotes polyclonal
T9068 42601-42607 NN denotes rabbit
T9069 42608-42618 JJ denotes anti-human
T9070 42619-42625 NN denotes TRIP13
T9071 42635-42636 -LRB- denotes (
T9072 42650-42656 NNP denotes Genway
T9073 42636-42638 CD denotes 18
T9074 42643-42648 CD denotes 42687
T9075 42638-42639 HYPH denotes -
T9076 42639-42642 CD denotes 003
T9077 42642-42643 HYPH denotes -
T9078 42648-42649 : denotes ;
T9079 42656-42658 , denotes ,
T9080 42658-42682 NN denotes http://www.genwaybio.com
T9081 42682-42683 -RRB- denotes )
T9082 42683-42684 . denotes .
T9083 42684-42810 sentence denotes According to the manufacturer, the immunogen was a synthetic peptide embedded in sequence we deduced to correspond to exon 3.
T9084 42685-42694 VBG denotes According
T9085 42730-42733 VBD denotes was
T9086 42695-42697 IN denotes to
T9087 42698-42701 DT denotes the
T9088 42702-42714 NN denotes manufacturer
T9089 42714-42716 , denotes ,
T9090 42716-42719 DT denotes the
T9091 42720-42729 NN denotes immunogen
T9092 42734-42735 DT denotes a
T9093 42746-42753 NN denotes peptide
T9094 42736-42745 JJ denotes synthetic
T9095 42754-42762 VBN denotes embedded
T9096 42763-42765 IN denotes in
T9097 42766-42774 NN denotes sequence
T9098 42775-42777 PRP denotes we
T9099 42778-42785 VBD denotes deduced
T9100 42786-42788 TO denotes to
T9158 43001-43006 NNP denotes Bouin
T9101 42789-42799 VB denotes correspond
T9102 42800-42802 IN denotes to
T9103 42803-42807 NN denotes exon
T9104 42808-42809 CD denotes 3
T9105 42809-42810 . denotes .
T9106 42810-42944 sentence denotes Binding was detected by chemiluminescence ECL kit (Pierce) using a rabbit anti-chicken IgG horseradish peroxidase conjugate (Pierce).
T9107 42811-42818 NN denotes Binding
T9108 42823-42831 VBN denotes detected
T9109 42819-42822 VBD denotes was
T9110 42832-42834 IN denotes by
T9111 42835-42852 NN denotes chemiluminescence
T9112 42857-42860 NN denotes kit
T9113 42853-42856 NN denotes ECL
T9114 42861-42862 -LRB- denotes (
T9115 42862-42868 NNP denotes Pierce
T9116 42868-42869 -RRB- denotes )
T9117 42870-42875 VBG denotes using
T9118 42876-42877 DT denotes a
T9119 42925-42934 NN denotes conjugate
T9120 42878-42884 NN denotes rabbit
T9121 42885-42897 JJ denotes anti-chicken
T9122 42898-42901 NN denotes IgG
T9123 42902-42913 NN denotes horseradish
T9124 42914-42924 NN denotes peroxidase
T9125 42935-42936 -LRB- denotes (
T9126 42936-42942 NNP denotes Pierce
T9127 42942-42943 -RRB- denotes )
T9128 42943-42944 . denotes .
T9148 42946-42958 JJ denotes Histological
T9159 43006-43008 POS denotes 's
T9149 42959-42967 NNS denotes analyses
T9150 42967-42968 . denotes .
T9151 42968-43088 sentence denotes Testes or ovaries were fixed in Bouin's, embedded in paraffin, sectioned at 6 μm, and stained by hematoxylin and eosin.
T9152 42969-42975 NNS denotes Testes
T9153 42992-42997 VBN denotes fixed
T9154 42976-42978 CC denotes or
T9155 42979-42986 NNS denotes ovaries
T9156 42987-42991 VBD denotes were
T9157 42998-43000 IN denotes in
T9160 43008-43010 , denotes ,
T9161 43010-43018 VBN denotes embedded
T9162 43019-43021 IN denotes in
T9163 43022-43030 NN denotes paraffin
T9164 43030-43032 , denotes ,
T9165 43032-43041 VBN denotes sectioned
T9166 43042-43044 IN denotes at
T9167 43045-43046 CD denotes 6
T9168 43047-43049 NN denotes μm
T9169 43049-43051 , denotes ,
T9170 43051-43054 CC denotes and
T9171 43055-43062 VBN denotes stained
T9172 43063-43065 IN denotes by
T9173 43066-43077 NN denotes hematoxylin
T9174 43078-43081 CC denotes and
T9175 43082-43087 NN denotes eosin
T9176 43087-43088 . denotes .
T9177 43088-43173 sentence denotes Antigen retrieval for immunohistochemistry of testis sections was as described [60].
T9178 43089-43096 NN denotes Antigen
T9179 43097-43106 NN denotes retrieval
T9180 43151-43154 VBD denotes was
T9181 43107-43110 IN denotes for
T9182 43111-43131 NN denotes immunohistochemistry
T9183 43132-43134 IN denotes of
T9184 43135-43141 NN denotes testis
T9185 43142-43150 NNS denotes sections
T9186 43155-43157 IN denotes as
T9187 43158-43167 VBN denotes described
T9188 43168-43169 -LRB- denotes [
T9189 43169-43171 CD denotes 60
T9190 43171-43172 -RRB- denotes ]
T9191 43172-43173 . denotes .
T9192 43173-43233 sentence denotes Oocyte and follicle numbers were counted as described [61].
T9193 43174-43180 NN denotes Oocyte
T9194 43194-43201 NNS denotes numbers
T9195 43181-43184 CC denotes and
T9196 43185-43193 NN denotes follicle
T9197 43207-43214 VBN denotes counted
T9198 43202-43206 VBD denotes were
T9199 43215-43217 IN denotes as
T9200 43218-43227 VBN denotes described
T9201 43228-43229 -LRB- denotes [
T9202 43229-43231 CD denotes 61
T9203 43231-43232 -RRB- denotes ]
T9204 43232-43233 . denotes .
T9205 43233-43313 sentence denotes Only follicles containing an oocyte with a clearly visible nucleus were scored.
T9206 43234-43238 RB denotes Only
T9207 43239-43248 NNS denotes follicles
T9208 43306-43312 VBN denotes scored
T9209 43249-43259 VBG denotes containing
T9210 43260-43262 DT denotes an
T9211 43263-43269 NN denotes oocyte
T9212 43270-43274 IN denotes with
T9213 43275-43276 DT denotes a
T9214 43293-43300 NN denotes nucleus
T9215 43277-43284 RB denotes clearly
T9216 43285-43292 JJ denotes visible
T9217 43301-43305 VBD denotes were
T9218 43312-43313 . denotes .
T9322 43315-43334 NN denotes Immunocytochemistry
T9323 43334-43335 . denotes .
T9324 43335-43430 sentence denotes Immunolabeling of surface-spread spermatocytes and oocytes was performed as described [39,62].
T9325 43336-43350 NN denotes Immunolabeling
T9326 43399-43408 VBN denotes performed
T9327 43351-43353 IN denotes of
T9328 43354-43361 NN denotes surface
T9329 43369-43382 NNS denotes spermatocytes
T9330 43361-43362 HYPH denotes -
T9331 43362-43368 NN denotes spread
T9332 43383-43386 CC denotes and
T9333 43387-43394 NNS denotes oocytes
T9334 43395-43398 VBD denotes was
T9335 43409-43411 IN denotes as
T9336 43412-43421 VBN denotes described
T9337 43422-43423 -LRB- denotes [
T9338 43426-43428 CD denotes 62
T9339 43423-43425 CD denotes 39
T9340 43425-43426 , denotes ,
T9341 43428-43429 -RRB- denotes ]
T9342 43429-43430 . denotes .
T9343 43430-43806 sentence denotes To reach conclusions on the pattern of staining for various proteins, 30 (unless otherwise indicated) well-spread nuclei of particular meiotic stages were first identified under the fluorescent microscope on the basis of SYCP3 or STAG3 staining, then imaged at both appropriate wavelengths to determine the pattern of second proteins with focal patterns such as RAD51 or RPA.
T9344 43431-43433 TO denotes To
T9345 43434-43439 VB denotes reach
T9346 43592-43602 VBN denotes identified
T9347 43440-43451 NNS denotes conclusions
T9348 43452-43454 IN denotes on
T9349 43455-43458 DT denotes the
T9350 43459-43466 NN denotes pattern
T9351 43467-43469 IN denotes of
T9352 43470-43478 NN denotes staining
T9353 43479-43482 IN denotes for
T9354 43483-43490 JJ denotes various
T9355 43491-43499 NN denotes proteins
T9356 43499-43501 , denotes ,
T9357 43501-43503 CD denotes 30
T9358 43545-43551 NNS denotes nuclei
T9359 43504-43505 -LRB- denotes (
T9360 43522-43531 VBN denotes indicated
T9361 43505-43511 IN denotes unless
T9362 43512-43521 RB denotes otherwise
T9363 43531-43532 -RRB- denotes )
T9364 43533-43537 RB denotes well
T9365 43538-43544 VBN denotes spread
T9366 43537-43538 HYPH denotes -
T9367 43552-43554 IN denotes of
T9368 43555-43565 JJ denotes particular
T9369 43574-43580 NNS denotes stages
T9370 43566-43573 JJ denotes meiotic
T9371 43581-43585 VBD denotes were
T9372 43586-43591 RB denotes first
T9373 43603-43608 IN denotes under
T9374 43609-43612 DT denotes the
T9375 43625-43635 NN denotes microscope
T9376 43613-43624 JJ denotes fluorescent
T9377 43636-43638 IN denotes on
T9378 43639-43642 DT denotes the
T9379 43643-43648 NN denotes basis
T9380 43649-43651 IN denotes of
T9381 43652-43657 NN denotes SYCP3
T9382 43667-43675 NN denotes staining
T9383 43658-43660 CC denotes or
T9384 43661-43666 NN denotes STAG3
T9385 43675-43677 , denotes ,
T9386 43677-43681 RB denotes then
T9387 43682-43688 VBN denotes imaged
T9388 43689-43691 IN denotes at
T9389 43692-43696 DT denotes both
T9390 43709-43720 NNS denotes wavelengths
T9391 43697-43708 JJ denotes appropriate
T9392 43721-43723 TO denotes to
T9393 43724-43733 VB denotes determine
T9394 43734-43737 DT denotes the
T9395 43738-43745 NN denotes pattern
T9396 43746-43748 IN denotes of
T9397 43749-43755 JJ denotes second
T9398 43756-43764 NN denotes proteins
T9399 43765-43769 IN denotes with
T9400 43770-43775 JJ denotes focal
T9401 43776-43784 NNS denotes patterns
T9402 43785-43789 JJ denotes such
T9403 43790-43792 IN denotes as
T9404 43793-43798 NN denotes RAD51
T9405 43799-43801 CC denotes or
T9406 43802-43805 NN denotes RPA
T9407 43805-43806 . denotes .
T9408 43806-43915 sentence denotes Unless otherwise indicated, the panels shown in the figures were the exclusive or predominant patterns seen.
T9409 43807-43813 IN denotes Unless
T9410 43824-43833 VBN denotes indicated
T9411 43814-43823 RB denotes otherwise
T9412 43867-43871 VBD denotes were
T9413 43833-43835 , denotes ,
T9414 43835-43838 DT denotes the
T9415 43839-43845 NNS denotes panels
T9416 43846-43851 VBN denotes shown
T9417 43852-43854 IN denotes in
T9418 43855-43858 DT denotes the
T9419 43859-43866 NNS denotes figures
T9420 43872-43875 DT denotes the
T9421 43901-43909 NNS denotes patterns
T9422 43876-43885 JJ denotes exclusive
T9423 43886-43888 CC denotes or
T9424 43889-43900 JJ denotes predominant
T9425 43910-43914 VBN denotes seen
T9426 43914-43915 . denotes .
T9427 43915-44078 sentence denotes The exception for this approach was in the case of staining for MLH1 or MLH3 plus RAD51 (in which case SYCP3 or STAG3 was not available to find chromosome cores).
T9428 43916-43919 DT denotes The
T9429 43920-43929 NN denotes exception
T9430 43948-43951 VBD denotes was
T9431 43930-43933 IN denotes for
T9432 43934-43938 DT denotes this
T9433 43939-43947 NN denotes approach
T9434 43952-43954 IN denotes in
T9435 43955-43958 DT denotes the
T9436 43959-43963 NN denotes case
T9437 43964-43966 IN denotes of
T9438 43967-43975 VBG denotes staining
T9439 43976-43979 IN denotes for
T9440 43980-43984 NN denotes MLH1
T9441 43985-43987 CC denotes or
T9442 43988-43992 NN denotes MLH3
T9443 43993-43997 CC denotes plus
T9444 43998-44003 NN denotes RAD51
T9445 44004-44005 -LRB- denotes (
T9446 44005-44007 IN denotes in
T9447 44034-44037 VBD denotes was
T9448 44008-44013 WDT denotes which
T9449 44014-44018 NN denotes case
T9450 44019-44024 NN denotes SYCP3
T9451 44025-44027 CC denotes or
T9452 44028-44033 NN denotes STAG3
T9453 44038-44041 RB denotes not
T9454 44042-44051 JJ denotes available
T9455 44052-44054 TO denotes to
T9456 44055-44059 VB denotes find
T9457 44060-44070 NN denotes chromosome
T9458 44071-44076 NNS denotes cores
T9459 44076-44077 -RRB- denotes )
T9460 44077-44078 . denotes .
T9461 44078-44198 sentence denotes Nuclei in this situation were identified first by MLH1/3 foci clustering, then imaged for both fluorescent wavelengths.
T9462 44079-44085 NNS denotes Nuclei
T9463 44109-44119 VBN denotes identified
T9464 44086-44088 IN denotes in
T9465 44089-44093 DT denotes this
T9466 44094-44103 NN denotes situation
T9467 44104-44108 VBD denotes were
T9468 44120-44125 RB denotes first
T9469 44126-44128 IN denotes by
T9470 44129-44133 NN denotes MLH1
T9471 44136-44140 NNS denotes foci
T9472 44133-44134 HYPH denotes /
T9473 44134-44135 CD denotes 3
T9474 44141-44151 VBG denotes clustering
T9475 44151-44153 , denotes ,
T9476 44153-44157 RB denotes then
T9477 44158-44164 VBN denotes imaged
T9478 44165-44168 IN denotes for
T9479 44169-44173 DT denotes both
T9480 44186-44197 NNS denotes wavelengths
T9481 44174-44185 JJ denotes fluorescent
T9482 44197-44198 . denotes .
T9483 44198-45038 sentence denotes Primary antibodies used in this study were as follows: mouse anti-SCP3 (1:500; Abcam, http://www.abcam.com); rabbit anti-SYCP1 (1:1,000; a gift from C. Heyting) [63]; rabbit anti-REC8 (1:100; a gift from C. Heyting); rabbit anti-RAD51 (1:250, this polyclonal antibody recognizes both RAD51 and DMC1; Oncogene Research Products, http://www.merckbiosciences.co.uk); rabbit anti-γH2AX (1:500; Upstate Biotechnology, http://www.upstate.com/); rabbit anti-STAG3 (1:1,000; a gift from R. Jessberger); rabbit anti-MLH3 (1:400; a gift from P. Cohen); mouse-anti-human MLH1 (1:50; BD Biosciences, http://www.bdbiosciences.com); rabbit-anti-TopBP1 (1:100; a gift from J. Chen) [22]; mouse-anti-ubiquityl-histone H2A (1:200; Upstate Biotechnology); rabbit-anti-TRF2 (1:500; a gift from T. de Lange); and rabbit-anti-BLM (1:50; a gift from R. Freire).
T9484 44199-44206 JJ denotes Primary
T9485 44207-44217 NNS denotes antibodies
T9486 44237-44241 VBD denotes were
T9487 44218-44222 VBN denotes used
T9488 44223-44225 IN denotes in
T9489 44226-44230 DT denotes this
T9490 44231-44236 NN denotes study
T9491 44242-44244 IN denotes as
T9492 44245-44252 VBZ denotes follows
T9493 44252-44254 : denotes :
T9494 44254-44259 NN denotes mouse
T9495 44260-44269 JJ denotes anti-SCP3
T9496 44270-44271 -LRB- denotes (
T9497 44278-44283 NNP denotes Abcam
T9498 44271-44272 CD denotes 1
T9499 44272-44273 SYM denotes :
T9500 44273-44276 CD denotes 500
T9501 44276-44277 : denotes ;
T9502 44283-44285 , denotes ,
T9503 44285-44305 NN denotes http://www.abcam.com
T9504 44305-44306 -RRB- denotes )
T9505 44306-44307 : denotes ;
T9506 44308-44314 NN denotes rabbit
T9507 44315-44325 NN denotes anti-SYCP1
T9508 44326-44327 -LRB- denotes (
T9509 44338-44342 NN denotes gift
T9510 44327-44328 CD denotes 1
T9511 44328-44329 SYM denotes :
T9512 44329-44334 CD denotes 1,000
T9513 44334-44335 : denotes ;
T9514 44336-44337 DT denotes a
T9515 44343-44347 IN denotes from
T9516 44348-44350 NNP denotes C.
T9517 44351-44358 NNP denotes Heyting
T9518 44358-44359 -RRB- denotes )
T9519 44360-44361 -LRB- denotes [
T9520 44361-44363 CD denotes 63
T9521 44363-44364 -RRB- denotes ]
T9522 44364-44365 : denotes ;
T9523 44366-44372 NN denotes rabbit
T9524 44373-44382 NN denotes anti-REC8
T9525 44383-44384 -LRB- denotes (
T9526 44393-44397 NN denotes gift
T9527 44384-44385 CD denotes 1
T9528 44385-44386 SYM denotes :
T9529 44386-44389 CD denotes 100
T9530 44389-44390 : denotes ;
T9531 44391-44392 DT denotes a
T9532 44398-44402 IN denotes from
T9533 44403-44405 NNP denotes C.
T9534 44406-44413 NNP denotes Heyting
T9535 44413-44414 -RRB- denotes )
T9536 44414-44415 : denotes ;
T9537 44416-44422 NN denotes rabbit
T9538 44423-44433 NN denotes anti-RAD51
T9539 44434-44435 -LRB- denotes (
T9540 44517-44525 NNP denotes Products
T9541 44435-44436 CD denotes 1
T9542 44436-44437 SYM denotes :
T9543 44437-44440 CD denotes 250
T9544 44440-44442 , denotes ,
T9545 44442-44446 DT denotes this
T9546 44458-44466 NN denotes antibody
T9547 44447-44457 JJ denotes polyclonal
T9548 44467-44477 VBZ denotes recognizes
T9549 44478-44482 CC denotes both
T9550 44483-44488 NN denotes RAD51
T9551 44489-44492 CC denotes and
T9552 44493-44497 NN denotes DMC1
T9553 44497-44498 : denotes ;
T9554 44499-44507 NNP denotes Oncogene
T9555 44508-44516 NNP denotes Research
T9556 44525-44527 , denotes ,
T9557 44527-44560 NN denotes http://www.merckbiosciences.co.uk
T9558 44560-44561 -RRB- denotes )
T9559 44561-44562 : denotes ;
T9560 44563-44569 NN denotes rabbit
T9561 44570-44580 NN denotes anti-γH2AX
T9562 44581-44582 -LRB- denotes (
T9563 44597-44610 NNP denotes Biotechnology
T9564 44582-44583 CD denotes 1
T9565 44583-44584 SYM denotes :
T9566 44584-44587 CD denotes 500
T9567 44587-44588 : denotes ;
T9568 44589-44596 NNP denotes Upstate
T9569 44610-44612 , denotes ,
T9570 44612-44635 NN denotes http://www.upstate.com/
T9571 44635-44636 -RRB- denotes )
T9572 44636-44637 : denotes ;
T9573 44638-44644 NN denotes rabbit
T9574 44645-44655 NN denotes anti-STAG3
T9575 44656-44657 -LRB- denotes (
T9576 44668-44672 NN denotes gift
T9577 44657-44658 CD denotes 1
T9578 44658-44659 SYM denotes :
T9579 44659-44664 CD denotes 1,000
T9580 44664-44665 : denotes ;
T9581 44666-44667 DT denotes a
T9582 44673-44677 IN denotes from
T9583 44678-44680 NNP denotes R.
T9584 44681-44691 NNP denotes Jessberger
T9585 44691-44692 -RRB- denotes )
T9586 44692-44693 : denotes ;
T9587 44694-44700 NN denotes rabbit
T9588 44701-44710 NN denotes anti-MLH3
T9589 44711-44712 -LRB- denotes (
T9590 44721-44725 NN denotes gift
T9591 44712-44713 CD denotes 1
T9592 44713-44714 SYM denotes :
T9593 44714-44717 CD denotes 400
T9594 44717-44718 : denotes ;
T9595 44719-44720 DT denotes a
T9596 44726-44730 IN denotes from
T9597 44731-44733 NNP denotes P.
T9598 44734-44739 NNP denotes Cohen
T9599 44739-44740 -RRB- denotes )
T9600 44740-44741 : denotes ;
T9601 44742-44747 JJ denotes mouse
T9602 44759-44763 NN denotes MLH1
T9603 44747-44748 HYPH denotes -
T9604 44748-44758 JJ denotes anti-human
T9605 44764-44765 -LRB- denotes (
T9606 44774-44785 NNP denotes Biosciences
T9607 44765-44766 CD denotes 1
T9608 44766-44767 SYM denotes :
T9609 44767-44769 CD denotes 50
T9610 44769-44770 : denotes ;
T9611 44771-44773 NNP denotes BD
T9612 44785-44787 , denotes ,
T9613 44787-44815 NN denotes http://www.bdbiosciences.com
T9614 44815-44816 -RRB- denotes )
T9615 44816-44817 : denotes ;
T9616 44818-44824 NN denotes rabbit
T9617 44825-44836 NN denotes anti-TopBP1
T9618 44824-44825 HYPH denotes -
T9619 44837-44838 -LRB- denotes (
T9620 44847-44851 NN denotes gift
T9621 44838-44839 CD denotes 1
T9622 44839-44840 SYM denotes :
T9623 44840-44843 CD denotes 100
T9624 44843-44844 : denotes ;
T9625 44845-44846 DT denotes a
T9626 44852-44856 IN denotes from
T9627 44857-44859 NNP denotes J.
T9628 44860-44864 NNP denotes Chen
T9629 44864-44865 -RRB- denotes )
T9630 44866-44867 -LRB- denotes [
T9631 44867-44869 CD denotes 22
T9632 44869-44870 -RRB- denotes ]
T9633 44870-44871 : denotes ;
T9634 44872-44877 NN denotes mouse
T9635 44901-44904 NN denotes H2A
T9636 44877-44878 HYPH denotes -
T9637 44878-44892 JJ denotes anti-ubiquityl
T9638 44892-44893 HYPH denotes -
T9639 44893-44900 NN denotes histone
T9640 44905-44906 -LRB- denotes (
T9641 44921-44934 NNP denotes Biotechnology
T9642 44906-44907 CD denotes 1
T9643 44907-44908 SYM denotes :
T9644 44908-44911 CD denotes 200
T9645 44911-44912 : denotes ;
T9646 44913-44920 NNP denotes Upstate
T9647 44934-44935 -RRB- denotes )
T9648 44935-44936 : denotes ;
T9649 44937-44943 NN denotes rabbit
T9650 44944-44953 NN denotes anti-TRF2
T9651 44943-44944 HYPH denotes -
T9652 44954-44955 -LRB- denotes (
T9653 44964-44968 NN denotes gift
T9654 44955-44956 CD denotes 1
T9655 44956-44957 SYM denotes :
T9656 44957-44960 CD denotes 500
T9657 44960-44961 : denotes ;
T9658 44962-44963 DT denotes a
T9659 44969-44973 IN denotes from
T9660 44974-44976 NNP denotes T.
T9661 44980-44985 NNP denotes Lange
T9662 44977-44979 NNP denotes de
T9663 44985-44986 -RRB- denotes )
T9664 44986-44987 : denotes ;
T9665 44988-44991 CC denotes and
T9666 44992-44998 NN denotes rabbit
T9667 44999-45007 NN denotes anti-BLM
T9668 44998-44999 HYPH denotes -
T9669 45008-45009 -LRB- denotes (
T9670 45017-45021 NN denotes gift
T9671 45009-45010 CD denotes 1
T9672 45010-45011 SYM denotes :
T9673 45011-45013 CD denotes 50
T9674 45013-45014 : denotes ;
T9675 45015-45016 DT denotes a
T9676 45022-45026 IN denotes from
T9677 45027-45029 NNP denotes R.
T9678 45030-45036 NNP denotes Freire
T9679 45036-45037 -RRB- denotes )
T9680 45037-45038 . denotes .
T9681 45038-45195 sentence denotes All secondary antibodies conjugated with either Alexa Fluor 488 or 594 (Molecular Probes, http://probes.invitrogen.com/) were used at a dilution of 1:1,000.
T9682 45039-45042 DT denotes All
T9683 45053-45063 NNS denotes antibodies
T9684 45043-45052 JJ denotes secondary
T9685 45165-45169 VBN denotes used
T9686 45064-45074 VBN denotes conjugated
T9687 45075-45079 IN denotes with
T9688 45080-45086 CC denotes either
T9689 45099-45102 CD denotes 488
T9690 45087-45092 NNP denotes Alexa
T9691 45093-45098 NNP denotes Fluor
T9692 45103-45105 CC denotes or
T9693 45106-45109 CD denotes 594
T9694 45110-45111 -LRB- denotes (
T9695 45121-45127 NNP denotes Probes
T9696 45111-45120 NNP denotes Molecular
T9697 45127-45129 , denotes ,
T9698 45129-45158 NN denotes http://probes.invitrogen.com/
T9699 45158-45159 -RRB- denotes )
T9700 45160-45164 VBD denotes were
T9701 45170-45172 IN denotes at
T9702 45173-45174 DT denotes a
T9703 45175-45183 NN denotes dilution
T9704 45184-45186 IN denotes of
T9705 45187-45188 CD denotes 1
T9706 45188-45189 SYM denotes :
T9707 45189-45194 CD denotes 1,000
T9708 45194-45195 . denotes .
T9709 45195-45265 sentence denotes All images were taken with a 100× objective lens under immersion oil.
T9710 45196-45199 DT denotes All
T9711 45200-45206 NNS denotes images
T9712 45212-45217 VBN denotes taken
T9713 45207-45211 VBD denotes were
T9714 45218-45222 IN denotes with
T9715 45223-45224 DT denotes a
T9716 45240-45244 NN denotes lens
T9717 45225-45228 CD denotes 100
T9718 45228-45229 SYM denotes ×
T9719 45230-45239 NN denotes objective
T9720 45245-45250 IN denotes under
T9721 45251-45260 NN denotes immersion
T9722 45261-45264 NN denotes oil
T9723 45264-45265 . denotes .
T9753 45267-45276 NN denotes Metaphase
T9754 45279-45291 NN denotes spermatocyte
T9755 45277-45278 CD denotes I
T9756 45292-45299 NNS denotes spreads
T9757 45300-45303 CC denotes and
T9758 45304-45306 NN denotes OA
T9759 45307-45316 NN denotes treatment
T9760 45316-45317 . denotes .
T9761 45317-45486 sentence denotes Metaphase fixed spermatocytes from 8-mo-old Trip13RRB047 homozygotes, using 23-d-old wild-type mice as control, were prepared and stained with Giemsa as described [64].
T9762 45318-45327 NN denotes Metaphase
T9763 45328-45333 VBN denotes fixed
T9764 45334-45347 NNS denotes spermatocytes
T9765 45435-45443 VBN denotes prepared
T9766 45348-45352 IN denotes from
T9767 45353-45354 CD denotes 8
T9768 45355-45357 NN denotes mo
T9769 45354-45355 HYPH denotes -
T9770 45358-45361 JJ denotes old
T9771 45357-45358 HYPH denotes -
T9772 45375-45386 NNS denotes homozygotes
T9773 45362-45374 NN denotes Trip13RRB047
T9774 45386-45388 , denotes ,
T9775 45388-45393 VBG denotes using
T9776 45394-45396 CD denotes 23
T9777 45397-45398 NN denotes d
T9778 45396-45397 HYPH denotes -
T9779 45399-45402 JJ denotes old
T9780 45398-45399 HYPH denotes -
T9781 45413-45417 NNS denotes mice
T9782 45403-45407 JJ denotes wild
T9783 45408-45412 NN denotes type
T9784 45407-45408 HYPH denotes -
T9785 45418-45420 IN denotes as
T9786 45421-45428 NN denotes control
T9787 45428-45430 , denotes ,
T9788 45430-45434 VBD denotes were
T9789 45444-45447 CC denotes and
T9790 45448-45455 VBN denotes stained
T9791 45456-45460 IN denotes with
T9792 45461-45467 NNP denotes Giemsa
T9793 45468-45470 IN denotes as
T9794 45471-45480 VBN denotes described
T9795 45481-45482 -LRB- denotes [
T9796 45482-45484 CD denotes 64
T9797 45484-45485 -RRB- denotes ]
T9798 45485-45486 . denotes .
T9799 45486-45656 sentence denotes For OA treatment, cells were exposed to 5 μM OA (Calbiochem, http://www.emdbiosciences.com) for 6 h at 32 °C in a humidified environment of 5% CO2 before spreading [65].
T9800 45487-45490 IN denotes For
T9801 45516-45523 VBN denotes exposed
T9802 45491-45493 NN denotes OA
T9803 45494-45503 NN denotes treatment
T9804 45503-45505 , denotes ,
T9805 45505-45510 NNS denotes cells
T9806 45511-45515 VBD denotes were
T9807 45524-45526 IN denotes to
T9808 45527-45528 CD denotes 5
T9809 45529-45531 NN denotes μM
T9810 45532-45534 NN denotes OA
T9811 45535-45536 -LRB- denotes (
T9812 45536-45546 NNP denotes Calbiochem
T9813 45546-45548 , denotes ,
T9814 45548-45577 NN denotes http://www.emdbiosciences.com
T9815 45577-45578 -RRB- denotes )
T9816 45579-45582 IN denotes for
T9817 45583-45584 CD denotes 6
T9818 45585-45586 NN denotes h
T9819 45587-45589 IN denotes at
T9820 45590-45592 CD denotes 32
T9821 45593-45595 NN denotes °C
T9822 45596-45598 IN denotes in
T9823 45599-45600 DT denotes a
T9824 45612-45623 NN denotes environment
T9825 45601-45611 JJ denotes humidified
T9826 45624-45626 IN denotes of
T9827 45627-45628 CD denotes 5
T9828 45628-45629 NN denotes %
T9829 45630-45633 NN denotes CO2
T9830 45634-45640 IN denotes before
T9831 45641-45650 VBG denotes spreading
T9832 45651-45652 -LRB- denotes [
T9833 45652-45654 CD denotes 65
T9834 45654-45655 -RRB- denotes ]
T9835 45655-45656 . denotes .
T9836 45656-45745 sentence denotes These preparations were stained with DAPI to visualize metaphase nuclei and chromosomes.
T9837 45657-45662 DT denotes These
T9838 45663-45675 NNS denotes preparations
T9839 45681-45688 VBN denotes stained
T9840 45676-45680 VBD denotes were
T9841 45689-45693 IN denotes with
T9842 45694-45698 NN denotes DAPI
T9843 45699-45701 TO denotes to
T9844 45702-45711 VB denotes visualize
T9845 45712-45721 NN denotes metaphase
T9846 45722-45728 NNS denotes nuclei
T9847 45729-45732 CC denotes and
T9848 45733-45744 NNS denotes chromosomes
T9849 45744-45745 . denotes .
T9864 45747-45759 JJ denotes Phylogenetic
T9865 45760-45768 NNS denotes analyses
T9866 45768-45769 . denotes .
T9867 45769-45889 sentence denotes TRIP13 orthologs were identified by BLASTP searches of Genbank and other sources providing gene models such as Ensembl.
T9868 45770-45776 NN denotes TRIP13
T9869 45777-45786 NNS denotes orthologs
T9870 45792-45802 VBN denotes identified
T9871 45787-45791 VBD denotes were
T9872 45803-45805 IN denotes by
T9873 45806-45812 NNP denotes BLASTP
T9874 45813-45821 NNS denotes searches
T9875 45822-45824 IN denotes of
T9876 45825-45832 NNP denotes Genbank
T9877 45833-45836 CC denotes and
T9878 45837-45842 JJ denotes other
T9879 45843-45850 NNS denotes sources
T9880 45851-45860 VBG denotes providing
T9881 45861-45865 NN denotes gene
T9882 45866-45872 NNS denotes models
T9883 45873-45877 JJ denotes such
T9884 45878-45880 IN denotes as
T9885 45881-45888 NNP denotes Ensembl
T9886 45888-45889 . denotes .
T9887 45889-45938 sentence denotes The selected orthologs can be found in Table S1.
T9888 45890-45893 DT denotes The
T9889 45903-45912 NNS denotes orthologs
T9890 45894-45902 VBN denotes selected
T9891 45920-45925 VBN denotes found
T9892 45913-45916 MD denotes can
T9893 45917-45919 VB denotes be
T9894 45926-45928 IN denotes in
T9895 45929-45934 NN denotes Table
T9896 45935-45937 NN denotes S1
T9897 45937-45938 . denotes .
T9898 45938-46093 sentence denotes Amino acid alignments were done with Clustal W, using the default settings with and without removing the regions outside of the AAA-ATPase central domain.
T9899 45939-45944 NN denotes Amino
T9900 45945-45949 NN denotes acid
T9901 45950-45960 NNS denotes alignments
T9902 45966-45970 VBN denotes done
T9903 45961-45965 VBD denotes were
T9904 45971-45975 IN denotes with
T9905 45976-45983 NNP denotes Clustal
T9906 45984-45985 NNP denotes W
T9907 45985-45987 , denotes ,
T9908 45987-45992 VBG denotes using
T9909 45993-45996 DT denotes the
T9910 46005-46013 NNS denotes settings
T9911 45997-46004 NN denotes default
T9912 46014-46018 IN denotes with
T9913 46019-46022 CC denotes and
T9914 46023-46030 IN denotes without
T9915 46031-46039 VBG denotes removing
T9916 46040-46043 DT denotes the
T9917 46044-46051 NNS denotes regions
T9918 46052-46059 IN denotes outside
T9919 46060-46062 IN denotes of
T9920 46063-46066 DT denotes the
T9921 46086-46092 NN denotes domain
T9922 46067-46070 NN denotes AAA
T9923 46071-46077 NN denotes ATPase
T9924 46070-46071 HYPH denotes -
T9925 46078-46085 JJ denotes central
T9926 46092-46093 . denotes .
T9927 46093-46182 sentence denotes The trees were constructed by using the neighbor-joining method with Poisson correction.
T9928 46094-46097 DT denotes The
T9929 46098-46103 NNS denotes trees
T9930 46109-46120 VBN denotes constructed
T9931 46104-46108 VBD denotes were
T9932 46121-46123 IN denotes by
T9933 46124-46129 VBG denotes using
T9934 46130-46133 DT denotes the
T9935 46151-46157 NN denotes method
T9936 46134-46142 NN denotes neighbor
T9937 46143-46150 VBG denotes joining
T9938 46142-46143 HYPH denotes -
T9939 46158-46162 IN denotes with
T9940 46163-46170 NNP denotes Poisson
T9941 46171-46181 NN denotes correction
T9942 46181-46182 . denotes .
T9943 46182-46318 sentence denotes The reliability of internal branches was assessed by using 500 bootstrap replicates, and sites with gaps were ignored in this analysis.
T9944 46183-46186 DT denotes The
T9945 46187-46198 NN denotes reliability
T9946 46224-46232 VBN denotes assessed
T9947 46199-46201 IN denotes of
T9948 46202-46210 JJ denotes internal
T9949 46211-46219 NNS denotes branches
T9950 46220-46223 VBD denotes was
T9951 46233-46235 IN denotes by
T9952 46236-46241 VBG denotes using
T9953 46242-46245 CD denotes 500
T9954 46256-46266 NNS denotes replicates
T9955 46246-46255 NN denotes bootstrap
T9956 46266-46268 , denotes ,
T9957 46268-46271 CC denotes and
T9958 46272-46277 NNS denotes sites
T9959 46293-46300 VBN denotes ignored
T9960 46278-46282 IN denotes with
T9961 46283-46287 NNS denotes gaps
T9962 46288-46292 VBD denotes were
T9963 46301-46303 IN denotes in
T9964 46304-46308 DT denotes this
T9965 46309-46317 NN denotes analysis
T9966 46317-46318 . denotes .
T9967 46318-46401 sentence denotes Neighbor-joining searches were conducted by using the computer program MEGA3 [66].
T9968 46319-46327 NN denotes Neighbor
T9969 46328-46335 VBG denotes joining
T9970 46327-46328 HYPH denotes -
T9971 46336-46344 NNS denotes searches
T9972 46350-46359 VBN denotes conducted
T9973 46345-46349 VBD denotes were
T9974 46360-46362 IN denotes by
T9975 46363-46368 VBG denotes using
T9976 46369-46372 DT denotes the
T9977 46382-46389 NN denotes program
T9978 46373-46381 NN denotes computer
T9979 46390-46395 NNP denotes MEGA3
T9980 46396-46397 -LRB- denotes [
T9981 46397-46399 CD denotes 66
T9982 46399-46400 -RRB- denotes ]
T9983 46400-46401 . denotes .
T10169 7429-7432 DT denotes The
T10170 7444-7452 NN denotes Ortholog
T10171 7433-7438 NN denotes Mouse
T10172 7439-7443 NN denotes PCH2
T10173 7453-7459 NN denotes TRIP13
T10174 7460-7463 CC denotes and
T10175 7464-7474 NN denotes Expression
T10176 7475-7477 IN denotes in
T10177 7478-7482 JJ denotes Wild
T10178 7483-7487 NN denotes Type
T10179 7488-7491 CC denotes and
T10180 7492-7498 NN denotes Mutant
T10181 7498-7555 sentence denotes (A) Phylogenetic tree of presumed PCH2/TRIP13 orthologs.
T10182 7499-7500 -LRB- denotes (
T10183 7500-7501 LS denotes A
T10184 7516-7520 NN denotes tree
T10185 7501-7502 -RRB- denotes )
T10186 7503-7515 JJ denotes Phylogenetic
T10187 7521-7523 IN denotes of
T10188 7524-7532 JJ denotes presumed
T10189 7545-7554 NNS denotes orthologs
T10190 7533-7537 NN denotes PCH2
T10191 7538-7544 NN denotes TRIP13
T10192 7537-7538 HYPH denotes /
T10193 7554-7555 . denotes .
T10194 7555-7636 sentence denotes The database sequence accession number of each protein is presented in Table S1.
T10195 7556-7559 DT denotes The
T10196 7588-7594 NN denotes number
T10197 7560-7568 NN denotes database
T10198 7569-7577 NN denotes sequence
T10199 7578-7587 NN denotes accession
T10200 7614-7623 VBN denotes presented
T10201 7595-7597 IN denotes of
T10202 7598-7602 DT denotes each
T10203 7603-7610 NN denotes protein
T10204 7611-7613 VBZ denotes is
T10205 7624-7626 IN denotes in
T10206 7627-7632 NN denotes Table
T10207 7633-7635 NN denotes S1
T10208 7635-7636 . denotes .
T10209 7636-7700 sentence denotes Numbers shown are bootstrap values (see Materials and Methods).
T10210 7637-7644 NNS denotes Numbers
T10211 7651-7654 VBP denotes are
T10212 7645-7650 VBN denotes shown
T10213 7655-7664 NN denotes bootstrap
T10214 7665-7671 NNS denotes values
T10215 7672-7673 -LRB- denotes (
T10216 7673-7676 VB denotes see
T10217 7677-7686 NNS denotes Materials
T10218 7687-7690 CC denotes and
T10219 7691-7698 NNS denotes Methods
T10220 7698-7699 -RRB- denotes )
T10221 7699-7700 . denotes .
T10222 7700-7885 sentence denotes The clustering was the same regardless of whether the whole entire AA sequence or trimmed sequences (where regions showing little conservation were removed) were used for the analysis.
T10223 7701-7704 DT denotes The
T10224 7705-7715 NN denotes clustering
T10225 7716-7719 VBD denotes was
T10226 7720-7723 DT denotes the
T10227 7724-7728 JJ denotes same
T10228 7729-7739 RB denotes regardless
T10229 7740-7742 IN denotes of
T10230 7743-7750 IN denotes whether
T10231 7863-7867 VBN denotes used
T10232 7751-7754 DT denotes the
T10233 7771-7779 NN denotes sequence
T10234 7755-7760 JJ denotes whole
T10235 7761-7767 JJ denotes entire
T10236 7768-7770 NN denotes AA
T10237 7780-7782 CC denotes or
T10238 7783-7790 VBN denotes trimmed
T10239 7791-7800 NNS denotes sequences
T10240 7801-7802 -LRB- denotes (
T10241 7802-7807 WRB denotes where
T10242 7849-7856 VBN denotes removed
T10243 7808-7815 NNS denotes regions
T10244 7816-7823 VBG denotes showing
T10245 7824-7830 JJ denotes little
T10246 7831-7843 NN denotes conservation
T10247 7844-7848 VBD denotes were
T10248 7856-7857 -RRB- denotes )
T10249 7858-7862 VBD denotes were
T10250 7868-7871 IN denotes for
T10251 7872-7875 DT denotes the
T10252 7876-7884 NN denotes analysis
T10253 7884-7885 . denotes .
T10254 7885-8022 sentence denotes Major eukaryotic groups are indicated in color, with deuterostomia in blue, plants in green, protostomia in purple, and fungi in maroon.
T10255 7886-7891 JJ denotes Major
T10256 7903-7909 NNS denotes groups
T10257 7892-7902 JJ denotes eukaryotic
T10258 7914-7923 VBN denotes indicated
T10259 7910-7913 VBP denotes are
T10260 7924-7926 IN denotes in
T10261 7927-7932 NN denotes color
T10262 7932-7934 , denotes ,
T10263 7934-7938 IN denotes with
T10264 7953-7955 IN denotes in
T10265 7939-7952 NN denotes deuterostomia
T10266 7956-7960 NN denotes blue
T10267 7960-7962 , denotes ,
T10268 7962-7968 NNS denotes plants
T10269 7969-7971 IN denotes in
T10270 7972-7977 NN denotes green
T10271 7977-7979 , denotes ,
T10272 7979-7990 NN denotes protostomia
T10273 7991-7993 IN denotes in
T10274 7994-8000 NN denotes purple
T10275 8000-8002 , denotes ,
T10276 8002-8005 CC denotes and
T10277 8006-8011 NNS denotes fungi
T10278 8012-8014 IN denotes in
T10279 8015-8021 NN denotes maroon
T10280 8021-8022 . denotes .
T10281 8022-8243 sentence denotes (B) Amplification products of cDNA from the following tissues: 1, heart; 2, brain; 3, spleen; 4, lung; 5, liver; 6, skeletal muscle; 7, kidney; 8, testis; 9, E7 embryo; 10, E11 embryo; 11, E15 embryo; and 12, E17 embryo.
T10282 8023-8024 -LRB- denotes (
T10283 8024-8025 LS denotes B
T10284 8041-8049 NNS denotes products
T10285 8025-8026 -RRB- denotes )
T10286 8027-8040 NN denotes Amplification
T10287 8050-8052 IN denotes of
T10288 8053-8057 NN denotes cDNA
T10289 8058-8062 IN denotes from
T10290 8063-8066 DT denotes the
T10291 8077-8084 NNS denotes tissues
T10292 8067-8076 JJ denotes following
T10293 8084-8086 : denotes :
T10294 8086-8087 LS denotes 1
T10295 8089-8094 NN denotes heart
T10296 8087-8089 , denotes ,
T10297 8094-8095 : denotes ;
T10298 8096-8097 LS denotes 2
T10299 8099-8104 NN denotes brain
T10300 8097-8099 , denotes ,
T10301 8104-8105 : denotes ;
T10302 8106-8107 LS denotes 3
T10303 8109-8115 NN denotes spleen
T10304 8107-8109 , denotes ,
T10305 8115-8116 : denotes ;
T10306 8117-8118 LS denotes 4
T10307 8120-8124 NN denotes lung
T10308 8118-8120 , denotes ,
T10309 8124-8125 : denotes ;
T10310 8126-8127 LS denotes 5
T10311 8129-8134 NN denotes liver
T10312 8127-8129 , denotes ,
T10313 8134-8135 : denotes ;
T10314 8136-8137 LS denotes 6
T10315 8148-8154 NN denotes muscle
T10316 8137-8139 , denotes ,
T10317 8139-8147 JJ denotes skeletal
T10318 8154-8155 : denotes ;
T10319 8156-8157 LS denotes 7
T10320 8159-8165 NN denotes kidney
T10321 8157-8159 , denotes ,
T10322 8165-8166 : denotes ;
T10323 8167-8168 LS denotes 8
T10324 8170-8176 NN denotes testis
T10325 8168-8170 , denotes ,
T10326 8176-8177 : denotes ;
T10327 8178-8179 LS denotes 9
T10328 8184-8190 NN denotes embryo
T10329 8179-8181 , denotes ,
T10330 8181-8183 NN denotes E7
T10331 8190-8191 : denotes ;
T10332 8192-8194 LS denotes 10
T10333 8200-8206 NN denotes embryo
T10334 8194-8196 , denotes ,
T10335 8196-8199 NN denotes E11
T10336 8206-8207 : denotes ;
T10337 8208-8210 LS denotes 11
T10338 8216-8222 NN denotes embryo
T10339 8210-8212 , denotes ,
T10340 8212-8215 NN denotes E15
T10341 8222-8223 : denotes ;
T10342 8224-8227 CC denotes and
T10343 8228-8230 LS denotes 12
T10344 8236-8242 NN denotes embryo
T10345 8230-8232 , denotes ,
T10346 8232-8235 NN denotes E17
T10347 8242-8243 . denotes .
T10348 8243-8319 sentence denotes (C) Intron–exon structure of TRIP13 and insertion site of gene-trap vector.
T10349 8244-8245 -LRB- denotes (
T10350 8245-8246 LS denotes C
T10351 8260-8269 NN denotes structure
T10352 8246-8247 -RRB- denotes )
T10353 8248-8254 NN denotes Intron
T10354 8255-8259 NN denotes exon
T10355 8254-8255 HYPH denotes –
T10356 8270-8272 IN denotes of
T10357 8273-8279 NN denotes TRIP13
T10358 8280-8283 CC denotes and
T10359 8284-8293 NN denotes insertion
T10360 8294-8298 NN denotes site
T10361 8299-8301 IN denotes of
T10362 8302-8306 NN denotes gene
T10363 8307-8311 NN denotes trap
T10364 8306-8307 HYPH denotes -
T10365 8312-8318 NN denotes vector
T10366 8318-8319 . denotes .
T10367 8319-8407 sentence denotes See Materials and Methods for details on how the precise insertion site was identified.
T10368 8320-8323 VB denotes See
T10369 8324-8333 NNS denotes Materials
T10370 8334-8337 CC denotes and
T10371 8338-8345 NNS denotes Methods
T10372 8346-8349 IN denotes for
T10373 8350-8357 NNS denotes details
T10374 8358-8360 IN denotes on
T10375 8361-8364 WRB denotes how
T10376 8396-8406 VBN denotes identified
T10377 8365-8368 DT denotes the
T10378 8387-8391 NN denotes site
T10379 8369-8376 JJ denotes precise
T10380 8377-8386 NN denotes insertion
T10381 8392-8395 VBD denotes was
T10382 8406-8407 . denotes .
T10383 8407-8470 sentence denotes (D) RT-PCR of Trip13 and a control gene Med31 from testis RNA.
T10384 8408-8409 -LRB- denotes (
T10385 8409-8410 LS denotes D
T10386 8415-8418 NN denotes PCR
T10387 8410-8411 -RRB- denotes )
T10388 8412-8414 NN denotes RT
T10389 8414-8415 HYPH denotes -
T10390 8419-8421 IN denotes of
T10391 8422-8428 NN denotes Trip13
T10392 8429-8432 CC denotes and
T10393 8433-8434 DT denotes a
T10394 8448-8453 NN denotes Med31
T10395 8435-8442 NN denotes control
T10396 8443-8447 NN denotes gene
T10397 8454-8458 IN denotes from
T10398 8459-8465 NN denotes testis
T10399 8466-8469 NN denotes RNA
T10400 8469-8470 . denotes .
T10401 8470-8559 sentence denotes The Trip13 primers are situated in the first and last exons (see Materials and Methods).
T10402 8471-8474 DT denotes The
T10403 8482-8489 NNS denotes primers
T10404 8475-8481 NN denotes Trip13
T10405 8494-8502 VBN denotes situated
T10406 8490-8493 VBP denotes are
T10407 8503-8505 IN denotes in
T10408 8506-8509 DT denotes the
T10409 8525-8530 NNS denotes exons
T10410 8510-8515 JJ denotes first
T10411 8516-8519 CC denotes and
T10412 8520-8524 JJ denotes last
T10413 8531-8532 -LRB- denotes (
T10414 8532-8535 VB denotes see
T10415 8536-8545 NNS denotes Materials
T10416 8546-8549 CC denotes and
T10417 8550-8557 NNS denotes Methods
T10418 8557-8558 -RRB- denotes )
T10419 8558-8559 . denotes .
T10420 8559-8630 sentence denotes (E) Western blot analysis of testis protein with anti-TRIP13 antibody.
T10421 8560-8561 -LRB- denotes (
T10422 8561-8562 LS denotes E
T10423 8577-8585 NN denotes analysis
T10424 8562-8563 -RRB- denotes )
T10425 8564-8571 NNP denotes Western
T10426 8572-8576 NN denotes blot
T10427 8586-8588 IN denotes of
T10428 8589-8595 NN denotes testis
T10429 8596-8603 NN denotes protein
T10430 8604-8608 IN denotes with
T10431 8609-8620 JJ denotes anti-TRIP13
T10432 8621-8629 NN denotes antibody
T10433 8629-8630 . denotes .
T10434 8630-8708 sentence denotes The blot was later probed with anti-alpha tubulin actin as a loading control.
T10435 8631-8634 DT denotes The
T10436 8635-8639 NN denotes blot
T10437 8650-8656 VBN denotes probed
T10438 8640-8643 VBD denotes was
T10439 8644-8649 RB denotes later
T10440 8657-8661 IN denotes with
T10441 8662-8672 JJ denotes anti-alpha
T10442 8681-8686 NN denotes actin
T10443 8673-8680 NN denotes tubulin
T10444 8687-8689 IN denotes as
T10445 8690-8691 DT denotes a
T10446 8700-8707 NN denotes control
T10447 8692-8699 NN denotes loading
T10448 8707-8708 . denotes .
T10449 8708-8748 sentence denotes The expected TRIP13 protein is ∼48 KDa.
T10450 8709-8712 DT denotes The
T10451 8729-8736 NN denotes protein
T10452 8713-8721 JJ denotes expected
T10453 8722-8728 NN denotes TRIP13
T10454 8737-8739 VBZ denotes is
T10455 8740-8741 SYM denotes ∼
T10456 8741-8743 CD denotes 48
T10457 8744-8747 NN denotes KDa
T10458 8747-8748 . denotes .
T10459 8748-8786 sentence denotes (F) Localization of TRIP13 in testes.
T10460 8749-8750 -LRB- denotes (
T10461 8750-8751 LS denotes F
T10462 8753-8765 NN denotes Localization
T10463 8751-8752 -RRB- denotes )
T10464 8766-8768 IN denotes of
T10465 8769-8775 NN denotes TRIP13
T10466 8776-8778 IN denotes in
T10467 8779-8785 NNS denotes testes
T10468 8785-8786 . denotes .
T10469 8786-8948 sentence denotes Wild-type (top) and mutant (bottom) testis sections were probed with chicken anti-TRIP13, and detected with HRP-conjugated anti-chicken IgG (brown/red staining).
T10470 8787-8791 JJ denotes Wild
T10471 8792-8796 NN denotes type
T10472 8791-8792 HYPH denotes -
T10473 8823-8829 NN denotes testis
T10474 8797-8798 -LRB- denotes (
T10475 8798-8801 JJ denotes top
T10476 8801-8802 -RRB- denotes )
T10477 8803-8806 CC denotes and
T10478 8807-8813 NN denotes mutant
T10479 8814-8815 -LRB- denotes (
T10480 8815-8821 JJ denotes bottom
T10481 8821-8822 -RRB- denotes )
T10482 8830-8838 NNS denotes sections
T10483 8844-8850 VBN denotes probed
T10484 8839-8843 VBD denotes were
T10485 8851-8855 IN denotes with
T10486 8856-8863 NN denotes chicken
T10487 8864-8875 JJ denotes anti-TRIP13
T10488 8875-8877 , denotes ,
T10489 8877-8880 CC denotes and
T10490 8881-8889 VBN denotes detected
T10491 8890-8894 IN denotes with
T10492 8895-8898 NN denotes HRP
T10493 8899-8909 VBN denotes conjugated
T10494 8898-8899 HYPH denotes -
T10495 8923-8926 NN denotes IgG
T10496 8910-8922 JJ denotes anti-chicken
T10497 8927-8928 -LRB- denotes (
T10498 8938-8946 NN denotes staining
T10499 8928-8933 JJ denotes brown
T10500 8934-8937 JJ denotes red
T10501 8933-8934 HYPH denotes /
T10502 8946-8947 -RRB- denotes )
T10503 8947-8948 . denotes .
T10504 8948-9141 sentence denotes Expression in WT was most prominent in the nuclei of Type B spermatogonia (Sg), leptotene spermatocytes (LS), and early pachytene spermatocytes (PS), but not late pachytene spermatocytes (LP).
T10505 8949-8959 NN denotes Expression
T10506 8966-8969 VBD denotes was
T10507 8960-8962 IN denotes in
T10508 8963-8965 NN denotes WT
T10509 8970-8974 RBS denotes most
T10510 8975-8984 JJ denotes prominent
T10511 8985-8987 IN denotes in
T10512 8988-8991 DT denotes the
T10513 8992-8998 NNS denotes nuclei
T10514 8999-9001 IN denotes of
T10515 9002-9006 NN denotes Type
T10516 9007-9008 NN denotes B
T10517 9009-9022 NNS denotes spermatogonia
T10518 9023-9024 -LRB- denotes (
T10519 9024-9026 NN denotes Sg
T10520 9026-9027 -RRB- denotes )
T10521 9027-9029 , denotes ,
T10522 9029-9038 NN denotes leptotene
T10523 9039-9052 NNS denotes spermatocytes
T10524 9053-9054 -LRB- denotes (
T10525 9054-9056 NNS denotes LS
T10526 9056-9057 -RRB- denotes )
T10527 9057-9059 , denotes ,
T10528 9059-9062 CC denotes and
T10529 9063-9068 JJ denotes early
T10530 9079-9092 NNS denotes spermatocytes
T10531 9069-9078 NN denotes pachytene
T10532 9093-9094 -LRB- denotes (
T10533 9094-9096 NN denotes PS
T10534 9096-9097 -RRB- denotes )
T10535 9097-9099 , denotes ,
T10536 9099-9102 CC denotes but
T10537 9103-9106 RB denotes not
T10538 9107-9111 JJ denotes late
T10539 9122-9135 NNS denotes spermatocytes
T10540 9112-9121 NN denotes pachytene
T10541 9136-9137 -LRB- denotes (
T10542 9137-9139 NN denotes LP
T10543 9139-9140 -RRB- denotes )
T10544 9140-9141 . denotes .
T10545 9141-9249 sentence denotes No nuclear staining was seen in mutant testis sections, although reddish cytoplasmic background is present.
T10546 9142-9144 DT denotes No
T10547 9153-9161 NN denotes staining
T10548 9145-9152 JJ denotes nuclear
T10549 9166-9170 VBN denotes seen
T10550 9162-9165 VBD denotes was
T10551 9171-9173 IN denotes in
T10552 9174-9180 NN denotes mutant
T10553 9188-9196 NNS denotes sections
T10554 9181-9187 NN denotes testis
T10555 9196-9198 , denotes ,
T10556 9198-9206 IN denotes although
T10557 9238-9240 VBZ denotes is
T10558 9207-9214 JJ denotes reddish
T10559 9227-9237 NN denotes background
T10560 9215-9226 JJ denotes cytoplasmic
T10561 9241-9248 JJ denotes present
T10562 9248-9249 . denotes .
T10563 9249-9366 sentence denotes Identification of cell types was judged in part by estimating the epithelial stage of the tubules as described [67].
T10564 9250-9264 NN denotes Identification
T10565 9283-9289 VBN denotes judged
T10566 9265-9267 IN denotes of
T10567 9268-9272 NN denotes cell
T10568 9273-9278 NNS denotes types
T10569 9279-9282 VBD denotes was
T10570 9290-9292 IN denotes in
T10571 9293-9297 JJ denotes part
T10572 9298-9300 IN denotes by
T10573 9301-9311 VBG denotes estimating
T10574 9312-9315 DT denotes the
T10575 9327-9332 NN denotes stage
T10576 9316-9326 JJ denotes epithelial
T10577 9333-9335 IN denotes of
T10578 9336-9339 DT denotes the
T10579 9340-9347 NNS denotes tubules
T10580 9348-9350 IN denotes as
T10581 9351-9360 VBN denotes described
T10582 9361-9362 -LRB- denotes [
T10583 9362-9364 CD denotes 67
T10584 9364-9365 -RRB- denotes ]
T10585 9365-9366 . denotes .
T10586 9366-9423 sentence denotes (G) TRIP13 localization in surface-spread spermatocytes.
T10587 9367-9368 -LRB- denotes (
T10588 9368-9369 LS denotes G
T10589 9378-9390 NN denotes localization
T10590 9369-9370 -RRB- denotes )
T10591 9371-9377 NN denotes TRIP13
T10592 9391-9393 IN denotes in
T10593 9394-9401 NN denotes surface
T10594 9402-9408 NN denotes spread
T10595 9401-9402 HYPH denotes -
T10596 9409-9422 NNS denotes spermatocytes
T10597 9422-9423 . denotes .
T10598 9423-9491 sentence denotes Preparations were immunolabeled with anti-SYCP3 (S) and TRIP13 (T).
T10599 9424-9436 NNS denotes Preparations
T10600 9442-9455 VBN denotes immunolabeled
T10601 9437-9441 VBD denotes were
T10602 9456-9460 IN denotes with
T10603 9461-9471 JJ denotes anti-SYCP3
T10604 9472-9473 -LRB- denotes (
T10605 9473-9474 NN denotes S
T10606 9474-9475 -RRB- denotes )
T10607 9476-9479 CC denotes and
T10608 9480-9486 NN denotes TRIP13
T10609 9487-9488 -LRB- denotes (
T10610 9488-9489 NN denotes T
T10611 9489-9490 -RRB- denotes )
T10612 9490-9491 . denotes .
T10613 9491-9607 sentence denotes Both individual and merged images are shown for leptotene (Lep), zygotene (Zyg), and pachytene (Pac) spermatocytes.
T10614 9492-9496 CC denotes Both
T10615 9497-9507 JJ denotes individual
T10616 9519-9525 NNS denotes images
T10617 9508-9511 CC denotes and
T10618 9512-9518 VBN denotes merged
T10619 9530-9535 VBN denotes shown
T10620 9526-9529 VBP denotes are
T10621 9536-9539 IN denotes for
T10622 9540-9549 NN denotes leptotene
T10623 9593-9606 NNS denotes spermatocytes
T10624 9550-9551 -LRB- denotes (
T10625 9551-9554 NN denotes Lep
T10626 9554-9555 -RRB- denotes )
T10627 9555-9557 , denotes ,
T10628 9557-9565 NN denotes zygotene
T10629 9566-9567 -LRB- denotes (
T10630 9567-9570 NN denotes Zyg
T10631 9570-9571 -RRB- denotes )
T10632 9571-9573 , denotes ,
T10633 9573-9576 CC denotes and
T10634 9577-9586 NN denotes pachytene
T10635 9587-9588 -LRB- denotes (
T10636 9588-9591 NN denotes Pac
T10637 9591-9592 -RRB- denotes )
T10638 9606-9607 . denotes .
T10639 9607-9650 sentence denotes Nuclear staining was absent in the mutant.
T10640 9608-9615 JJ denotes Nuclear
T10641 9616-9624 NN denotes staining
T10642 9625-9628 VBD denotes was
T10643 9629-9635 JJ denotes absent
T10644 9636-9638 IN denotes in
T10645 9639-9642 DT denotes the
T10646 9643-9649 NN denotes mutant
T10647 9649-9650 . denotes .
T10698 10382-10395 JJ denotes Developmental
T10699 10396-10406 NNS denotes Phenotypes
T10700 10407-10409 IN denotes of
T10701 10410-10416 NN denotes Trip13
T10702 10417-10423 NN denotes Mutant
T10703 10424-10428 NNS denotes Mice
T10704 10428-10464 sentence denotes (A) Shown are 21-d-old littermates.
T10705 10429-10430 -LRB- denotes (
T10706 10430-10431 LS denotes A
T10707 10439-10442 VBP denotes are
T10708 10431-10432 -RRB- denotes )
T10709 10433-10438 VBN denotes Shown
T10710 10443-10445 CD denotes 21
T10711 10446-10447 NN denotes d
T10712 10445-10446 HYPH denotes -
T10713 10448-10451 JJ denotes old
T10714 10447-10448 HYPH denotes -
T10715 10452-10463 NNS denotes littermates
T10716 10463-10464 . denotes .
T10717 10464-10534 sentence denotes Note the shortened tail in the mutant, but overall similar body size.
T10718 10465-10469 VB denotes Note
T10719 10470-10473 DT denotes the
T10720 10484-10488 NN denotes tail
T10721 10474-10483 VBN denotes shortened
T10722 10489-10491 IN denotes in
T10723 10492-10495 DT denotes the
T10724 10496-10502 NN denotes mutant
T10725 10502-10504 , denotes ,
T10726 10504-10507 CC denotes but
T10727 10508-10515 JJ denotes overall
T10728 10516-10523 JJ denotes similar
T10729 10529-10533 NN denotes size
T10730 10524-10528 NN denotes body
T10731 10533-10534 . denotes .
T10732 10534-10570 sentence denotes (B) Shown are 23-d-old littermates.
T10733 10535-10536 -LRB- denotes (
T10734 10536-10537 LS denotes B
T10735 10545-10548 VBP denotes are
T10736 10537-10538 -RRB- denotes )
T10737 10539-10544 VBN denotes Shown
T10738 10549-10551 CD denotes 23
T10739 10552-10553 NN denotes d
T10740 10551-10552 HYPH denotes -
T10741 10554-10557 JJ denotes old
T10742 10553-10554 HYPH denotes -
T10743 10558-10569 NNS denotes littermates
T10744 10569-10570 . denotes .
T10745 10570-10660 sentence denotes The mutant is smaller in this case, but the tail is not as truncated as the mouse in (A).
T10746 10571-10574 DT denotes The
T10747 10575-10581 NN denotes mutant
T10748 10582-10584 VBZ denotes is
T10749 10585-10592 JJR denotes smaller
T10750 10593-10595 IN denotes in
T10751 10596-10600 DT denotes this
T10752 10601-10605 NN denotes case
T10753 10605-10607 , denotes ,
T10754 10607-10610 CC denotes but
T10755 10611-10614 DT denotes the
T10756 10615-10619 NN denotes tail
T10757 10620-10622 VBZ denotes is
T10758 10623-10626 RB denotes not
T10759 10627-10629 RB denotes as
T10760 10630-10639 JJ denotes truncated
T10761 10640-10642 IN denotes as
T10762 10643-10646 DT denotes the
T10763 10647-10652 NN denotes mouse
T10764 10653-10655 IN denotes in
T10765 10656-10657 -LRB- denotes (
T10766 10657-10658 NN denotes A
T10767 10658-10659 -RRB- denotes )
T10768 10659-10660 . denotes .
T10769 10660-10722 sentence denotes (C) Wild-type (WT) and homozygous Trip13 mutant (MUT) testes.
T10770 10661-10662 -LRB- denotes (
T10771 10662-10663 LS denotes C
T10772 10715-10721 NNS denotes testes
T10773 10663-10664 -RRB- denotes )
T10774 10665-10669 JJ denotes Wild
T10775 10670-10674 NN denotes type
T10776 10669-10670 HYPH denotes -
T10777 10675-10676 -LRB- denotes (
T10778 10676-10678 NN denotes WT
T10779 10678-10679 -RRB- denotes )
T10780 10680-10683 CC denotes and
T10781 10684-10694 JJ denotes homozygous
T10782 10702-10708 NN denotes mutant
T10783 10695-10701 NN denotes Trip13
T10784 10709-10710 -LRB- denotes (
T10785 10710-10713 NN denotes MUT
T10786 10713-10714 -RRB- denotes )
T10787 10721-10722 . denotes .
T10788 10722-10843 sentence denotes (D) and (E) are cross sections through 17.5-d-old heterozygous (“WT”) and homozygous mutant Trip13 testes, respectively.
T10789 10723-10724 -LRB- denotes (
T10790 10724-10725 NN denotes D
T10791 10735-10738 VBP denotes are
T10792 10725-10726 -RRB- denotes )
T10793 10727-10730 CC denotes and
T10794 10731-10732 -LRB- denotes (
T10795 10732-10733 NN denotes E
T10796 10733-10734 -RRB- denotes )
T10797 10739-10744 NN denotes cross
T10798 10745-10753 NNS denotes sections
T10799 10754-10761 IN denotes through
T10800 10762-10766 CD denotes 17.5
T10801 10767-10768 NN denotes d
T10802 10766-10767 HYPH denotes -
T10803 10769-10772 JJ denotes old
T10804 10768-10769 HYPH denotes -
T10805 10822-10828 NNS denotes testes
T10806 10773-10785 JJ denotes heterozygous
T10807 10808-10814 NN denotes mutant
T10808 10786-10787 -LRB- denotes (
T10809 10788-10790 NN denotes WT
T10810 10787-10788 `` denotes “
T10811 10790-10791 '' denotes ”
T10812 10791-10792 -RRB- denotes )
T10813 10793-10796 CC denotes and
T10814 10797-10807 JJ denotes homozygous
T10815 10815-10821 NN denotes Trip13
T10816 10828-10830 , denotes ,
T10817 10830-10842 RB denotes respectively
T10818 10842-10843 . denotes .
T10819 10843-11056 sentence denotes Whereas the tubules in WT show coordinated spermatogenesis with pachytene spermatocytes present in all tubules (proximal to the lumen), developmental progression in the mutant is not synchronized between tubules.
T10820 10844-10851 IN denotes Whereas
T10821 10870-10874 VBP denotes show
T10822 10852-10855 DT denotes the
T10823 10856-10863 NNS denotes tubules
T10824 10864-10866 IN denotes in
T10825 10867-10869 NN denotes WT
T10826 11027-11039 VBN denotes synchronized
T10827 10875-10886 VBN denotes coordinated
T10828 10887-10902 NN denotes spermatogenesis
T10829 10903-10907 IN denotes with
T10830 10908-10917 NN denotes pachytene
T10831 10918-10931 NNS denotes spermatocytes
T10832 10932-10939 JJ denotes present
T10833 10940-10942 IN denotes in
T10834 10943-10946 DT denotes all
T10835 10947-10954 NNS denotes tubules
T10836 10955-10956 -LRB- denotes (
T10837 10956-10964 JJ denotes proximal
T10838 10965-10967 IN denotes to
T10839 10968-10971 DT denotes the
T10840 10972-10977 NN denotes lumen
T10841 10977-10978 -RRB- denotes )
T10842 10978-10980 , denotes ,
T10843 10980-10993 JJ denotes developmental
T10844 10994-11005 NN denotes progression
T10845 11006-11008 IN denotes in
T10846 11009-11012 DT denotes the
T10847 11013-11019 NN denotes mutant
T10848 11020-11022 VBZ denotes is
T10849 11023-11026 RB denotes not
T10850 11040-11047 IN denotes between
T10851 11048-11055 NNS denotes tubules
T10852 11055-11056 . denotes .
T10853 11056-11172 sentence denotes Some tubules have no pachytene spermatocyes (asterisks), while in others, development is somewhat disorganized (#).
T10854 11057-11061 DT denotes Some
T10855 11062-11069 NNS denotes tubules
T10856 11070-11074 VBP denotes have
T10857 11075-11077 DT denotes no
T10858 11088-11100 NNS denotes spermatocyes
T10859 11078-11087 NN denotes pachytene
T10860 11101-11102 -LRB- denotes (
T10861 11102-11111 NNS denotes asterisks
T10862 11111-11112 -RRB- denotes )
T10863 11112-11114 , denotes ,
T10864 11114-11119 IN denotes while
T10865 11143-11145 VBZ denotes is
T10866 11120-11122 IN denotes in
T10867 11123-11129 NNS denotes others
T10868 11129-11131 , denotes ,
T10869 11131-11142 NN denotes development
T10870 11146-11154 RB denotes somewhat
T10871 11155-11167 JJ denotes disorganized
T10872 11168-11169 -LRB- denotes (
T10873 11169-11170 SYM denotes #
T10874 11170-11171 -RRB- denotes )
T10875 11171-11172 . denotes .
T11057 13782-13791 NN denotes Histology
T11058 13792-13794 IN denotes of
T11059 13795-13801 NN denotes Mutant
T11060 13802-13808 NNS denotes Gonads
T11061 13808-13861 sentence denotes All are hematoxylin/eosin-stained paraffin sections.
T11062 13809-13812 DT denotes All
T11063 13813-13816 VBP denotes are
T11064 13817-13828 NN denotes hematoxylin
T11065 13829-13834 NN denotes eosin
T11066 13828-13829 HYPH denotes /
T11067 13835-13842 VBN denotes stained
T11068 13834-13835 HYPH denotes -
T11069 13852-13860 NNS denotes sections
T11070 13843-13851 NN denotes paraffin
T11071 13860-13861 . denotes .
T11072 13861-13920 sentence denotes Testes are from 6-wk-old males, except as indicated below.
T11073 13862-13868 NNS denotes Testes
T11074 13869-13872 VBP denotes are
T11075 13873-13877 IN denotes from
T11076 13878-13879 CD denotes 6
T11077 13880-13882 NN denotes wk
T11078 13879-13880 HYPH denotes -
T11079 13883-13886 JJ denotes old
T11080 13882-13883 HYPH denotes -
T11081 13887-13892 NNS denotes males
T11082 13892-13894 , denotes ,
T11083 13894-13900 IN denotes except
T11084 13901-13903 IN denotes as
T11085 13904-13913 VBN denotes indicated
T11086 13914-13919 RB denotes below
T11087 13919-13920 . denotes .
T11088 13920-13950 sentence denotes (A) Wild-type 25-d-old ovary.
T11089 13921-13922 -LRB- denotes (
T11090 13922-13923 LS denotes A
T11091 13944-13949 NN denotes ovary
T11092 13923-13924 -RRB- denotes )
T11093 13925-13929 JJ denotes Wild
T11094 13930-13934 NN denotes type
T11095 13929-13930 HYPH denotes -
T11096 13935-13937 CD denotes 25
T11097 13938-13939 NN denotes d
T11098 13937-13938 HYPH denotes -
T11099 13940-13943 JJ denotes old
T11100 13939-13940 HYPH denotes -
T11101 13949-13950 . denotes .
T11102 13950-14030 sentence denotes (B) Trip13Gt /Gt 25-d-old ovary, showing dysgenesis from an absence of oocytes.
T11103 13951-13952 -LRB- denotes (
T11104 13952-13953 LS denotes B
T11105 13977-13982 NN denotes ovary
T11106 13953-13954 -RRB- denotes )
T11107 13955-13963 NN denotes Trip13Gt
T11108 13965-13967 NN denotes Gt
T11109 13964-13965 HYPH denotes /
T11110 13968-13970 CD denotes 25
T11111 13971-13972 NN denotes d
T11112 13970-13971 HYPH denotes -
T11113 13973-13976 JJ denotes old
T11114 13972-13973 HYPH denotes -
T11115 13982-13984 , denotes ,
T11116 13984-13991 VBG denotes showing
T11117 13992-14002 NN denotes dysgenesis
T11118 14003-14007 IN denotes from
T11119 14008-14010 DT denotes an
T11120 14011-14018 NN denotes absence
T11121 14019-14021 IN denotes of
T11122 14022-14029 NNS denotes oocytes
T11123 14029-14030 . denotes .
T11124 14030-14068 sentence denotes (C) Trip13Gt/+ 2-d-old control ovary.
T11125 14031-14032 -LRB- denotes (
T11126 14032-14033 LS denotes C
T11127 14062-14067 NN denotes ovary
T11128 14033-14034 -RRB- denotes )
T11129 14035-14043 NN denotes Trip13Gt
T11130 14043-14044 HYPH denotes /
T11131 14044-14045 SYM denotes +
T11132 14046-14047 CD denotes 2
T11133 14048-14049 NN denotes d
T11134 14047-14048 HYPH denotes -
T11135 14050-14053 JJ denotes old
T11136 14049-14050 HYPH denotes -
T11137 14054-14061 NN denotes control
T11138 14067-14068 . denotes .
T11139 14068-14120 sentence denotes Arrows point to oocytes in newly forming follicles.
T11140 14069-14075 NNS denotes Arrows
T11141 14076-14081 VBP denotes point
T11142 14082-14084 IN denotes to
T11143 14085-14092 NNS denotes oocytes
T11144 14093-14095 IN denotes in
T11145 14096-14101 RB denotes newly
T11146 14102-14109 VBG denotes forming
T11147 14110-14119 NNS denotes follicles
T11148 14119-14120 . denotes .
T11149 14120-14184 sentence denotes (D) Trip13Gt/Gt 2-d-old ovary, dysgenic due to lack of oocytes.
T11150 14121-14122 -LRB- denotes (
T11151 14122-14123 LS denotes D
T11152 14145-14150 NN denotes ovary
T11153 14123-14124 -RRB- denotes )
T11154 14125-14133 NN denotes Trip13Gt
T11155 14134-14136 NN denotes Gt
T11156 14133-14134 HYPH denotes /
T11157 14137-14138 CD denotes 2
T11158 14139-14140 NN denotes d
T11159 14138-14139 HYPH denotes -
T11160 14141-14144 JJ denotes old
T11161 14140-14141 HYPH denotes -
T11162 14150-14152 , denotes ,
T11163 14152-14160 JJ denotes dysgenic
T11164 14161-14164 IN denotes due
T11165 14165-14167 IN denotes to
T11166 14168-14172 NN denotes lack
T11167 14173-14175 IN denotes of
T11168 14176-14183 NNS denotes oocytes
T11169 14183-14184 . denotes .
T11170 14184-14236 sentence denotes Magnification is the same as its littermate in “C.”
T11171 14185-14198 NN denotes Magnification
T11172 14199-14201 VBZ denotes is
T11173 14202-14205 DT denotes the
T11174 14206-14210 JJ denotes same
T11175 14211-14213 IN denotes as
T11176 14214-14217 PRP$ denotes its
T11177 14218-14228 NN denotes littermate
T11178 14229-14231 IN denotes in
T11179 14232-14233 `` denotes “
T11180 14233-14235 NN denotes C.
T11181 14235-14236 '' denotes ”
T11182 14236-14258 sentence denotes (E) Wild-type testis.
T11183 14237-14238 -LRB- denotes (
T11184 14238-14239 LS denotes E
T11185 14251-14257 NN denotes testis
T11186 14239-14240 -RRB- denotes )
T11187 14241-14245 JJ denotes Wild
T11188 14246-14250 NN denotes type
T11189 14245-14246 HYPH denotes -
T11190 14257-14258 . denotes .
T11191 14258-14312 sentence denotes (F) Trip13Gt/Gt testis with uniform pachytene arrest.
T11192 14259-14260 -LRB- denotes (
T11193 14260-14261 LS denotes F
T11194 14275-14281 NN denotes testis
T11195 14261-14262 -RRB- denotes )
T11196 14263-14271 NN denotes Trip13Gt
T11197 14272-14274 NN denotes Gt
T11198 14271-14272 HYPH denotes /
T11199 14282-14286 IN denotes with
T11200 14287-14294 JJ denotes uniform
T11201 14305-14311 NN denotes arrest
T11202 14295-14304 NN denotes pachytene
T11203 14311-14312 . denotes .
T11204 14312-14387 sentence denotes (G) Trip13Gt/Gt 3-mo-old testis with some postmeiotic spermatids (arrows).
T11205 14313-14314 -LRB- denotes (
T11206 14314-14315 LS denotes G
T11207 14338-14344 NN denotes testis
T11208 14315-14316 -RRB- denotes )
T11209 14317-14325 NN denotes Trip13Gt
T11210 14326-14328 NN denotes Gt
T11211 14325-14326 HYPH denotes /
T11212 14329-14330 CD denotes 3
T11213 14331-14333 NN denotes mo
T11214 14330-14331 HYPH denotes -
T11215 14334-14337 JJ denotes old
T11216 14333-14334 HYPH denotes -
T11217 14345-14349 IN denotes with
T11218 14350-14354 DT denotes some
T11219 14367-14377 NNS denotes spermatids
T11220 14355-14366 JJ denotes postmeiotic
T11221 14378-14379 -LRB- denotes (
T11222 14379-14385 NNS denotes arrows
T11223 14385-14386 -RRB- denotes )
T11224 14386-14387 . denotes .
T11225 14387-14408 sentence denotes (H) Spo11−/- testis.
T11226 14388-14389 -LRB- denotes (
T11227 14389-14390 LS denotes H
T11228 14401-14407 NN denotes testis
T11229 14390-14391 -RRB- denotes )
T11230 14392-14397 NN denotes Spo11
T11231 14397-14398 SYM denotes −
T11232 14398-14399 HYPH denotes /
T11233 14399-14400 SYM denotes -
T11234 14407-14408 . denotes .
T11235 14408-14554 sentence denotes A tubule with spermatocytes at leptotene/zygotene transition is labeled ZP, and tubules with apoptotic spermatocytes are marked with an asterisk.
T11236 14409-14410 DT denotes A
T11237 14411-14417 NN denotes tubule
T11238 14473-14480 VBN denotes labeled
T11239 14418-14422 IN denotes with
T11240 14423-14436 NNS denotes spermatocytes
T11241 14437-14439 IN denotes at
T11242 14440-14449 NN denotes leptotene
T11243 14450-14458 NN denotes zygotene
T11244 14449-14450 HYPH denotes /
T11245 14459-14469 NN denotes transition
T11246 14470-14472 VBZ denotes is
T11247 14481-14483 NN denotes ZP
T11248 14483-14485 , denotes ,
T11249 14485-14488 CC denotes and
T11250 14489-14496 NNS denotes tubules
T11251 14530-14536 VBN denotes marked
T11252 14497-14501 IN denotes with
T11253 14502-14511 JJ denotes apoptotic
T11254 14512-14525 NNS denotes spermatocytes
T11255 14526-14529 VBP denotes are
T11256 14537-14541 IN denotes with
T11257 14542-14544 DT denotes an
T11258 14545-14553 NN denotes asterisk
T11259 14553-14554 . denotes .
T11260 14554-14611 sentence denotes The specimen was taken from a littermate of that in (I).
T11261 14555-14558 DT denotes The
T11262 14559-14567 NN denotes specimen
T11263 14572-14577 VBN denotes taken
T11264 14568-14571 VBD denotes was
T11265 14578-14582 IN denotes from
T11266 14583-14584 DT denotes a
T11267 14585-14595 NN denotes littermate
T11268 14596-14598 IN denotes of
T11269 14599-14603 DT denotes that
T11270 14604-14606 IN denotes in
T11271 14607-14608 -LRB- denotes (
T11272 14608-14609 NN denotes I
T11273 14609-14610 -RRB- denotes )
T11274 14610-14611 . denotes .
T11275 14611-14645 sentence denotes (I) Spo11 −/− Trip13Gt/Gt testis.
T11276 14612-14613 -LRB- denotes (
T11277 14613-14614 LS denotes I
T11278 14638-14644 NN denotes testis
T11279 14614-14615 -RRB- denotes )
T11280 14616-14621 NN denotes Spo11
T11281 14622-14623 SYM denotes −
T11282 14623-14624 HYPH denotes /
T11283 14624-14625 SYM denotes −
T11284 14626-14634 NN denotes Trip13Gt
T11285 14635-14637 NN denotes Gt
T11286 14634-14635 HYPH denotes /
T11287 14644-14645 . denotes .
T11288 14645-14677 sentence denotes Labeling is the same as in (H).
T11289 14646-14654 NN denotes Labeling
T11290 14655-14657 VBZ denotes is
T11291 14658-14661 DT denotes the
T11292 14662-14666 JJ denotes same
T11293 14667-14669 IN denotes as
T11294 14670-14672 IN denotes in
T11295 14673-14674 -LRB- denotes (
T11296 14674-14675 NN denotes H
T11297 14675-14676 -RRB- denotes )
T11298 14676-14677 . denotes .
T11299 14677-14744 sentence denotes The inset contains a tubule with leptotene-zygotene spermatocytes.
T11300 14678-14681 DT denotes The
T11301 14682-14687 NN denotes inset
T11302 14688-14696 VBZ denotes contains
T11303 14697-14698 DT denotes a
T11304 14699-14705 NN denotes tubule
T11305 14706-14710 IN denotes with
T11306 14711-14720 NN denotes leptotene
T11307 14721-14729 NN denotes zygotene
T11308 14720-14721 HYPH denotes -
T11309 14730-14743 NNS denotes spermatocytes
T11310 14743-14744 . denotes .
T11311 14744-14776 sentence denotes (J) Mei1 −/− Trip13Gt/+ testis.
T11312 14745-14746 -LRB- denotes (
T11313 14746-14747 LS denotes J
T11314 14769-14775 NN denotes testis
T11315 14747-14748 -RRB- denotes )
T11316 14749-14753 NN denotes Mei1
T11317 14754-14755 SYM denotes −
T11318 14755-14756 HYPH denotes /
T11319 14756-14757 SYM denotes −
T11320 14758-14766 NN denotes Trip13Gt
T11321 14766-14767 HYPH denotes /
T11322 14767-14768 SYM denotes +
T11323 14775-14776 . denotes .
T11324 14776-14833 sentence denotes The specimen was taken from a littermate of that in (K).
T11325 14777-14780 DT denotes The
T11326 14781-14789 NN denotes specimen
T11327 14794-14799 VBN denotes taken
T11328 14790-14793 VBD denotes was
T11329 14800-14804 IN denotes from
T11330 14805-14806 DT denotes a
T11331 14807-14817 NN denotes littermate
T11332 14818-14820 IN denotes of
T11333 14821-14825 DT denotes that
T11334 14826-14828 IN denotes in
T11335 14829-14830 -LRB- denotes (
T11336 14830-14831 NN denotes K
T11337 14831-14832 -RRB- denotes )
T11338 14832-14833 . denotes .
T11339 14833-14866 sentence denotes (K) Mei1 −/− Trip13Gt/Gt testis.
T11340 14834-14835 -LRB- denotes (
T11341 14835-14836 LS denotes K
T11342 14859-14865 NN denotes testis
T11343 14836-14837 -RRB- denotes )
T11344 14838-14842 NN denotes Mei1
T11345 14843-14844 SYM denotes −
T11346 14844-14845 HYPH denotes /
T11347 14845-14846 SYM denotes −
T11348 14847-14855 NN denotes Trip13Gt
T11349 14856-14858 NN denotes Gt
T11350 14855-14856 HYPH denotes /
T11351 14865-14866 . denotes .
T11352 14866-14907 sentence denotes (L) Rec8Mei8/Rec8Mei8 Trip13Gt/+ testis.
T11353 14867-14868 -LRB- denotes (
T11354 14868-14869 LS denotes L
T11355 14900-14906 NN denotes testis
T11356 14869-14870 -RRB- denotes )
T11357 14871-14879 NN denotes Rec8Mei8
T11358 14880-14888 NN denotes Rec8Mei8
T11359 14879-14880 HYPH denotes /
T11360 14889-14897 NN denotes Trip13Gt
T11361 14897-14898 HYPH denotes /
T11362 14898-14899 SYM denotes +
T11363 14906-14907 . denotes .
T11364 14907-14947 sentence denotes The Rec8Mei8 allele was described [39].
T11365 14908-14911 DT denotes The
T11366 14921-14927 NN denotes allele
T11367 14912-14920 NN denotes Rec8Mei8
T11368 14932-14941 VBN denotes described
T11369 14928-14931 VBD denotes was
T11370 14942-14943 -LRB- denotes [
T11371 14943-14945 CD denotes 39
T11372 14945-14946 -RRB- denotes ]
T11373 14946-14947 . denotes .
T11374 14947-15004 sentence denotes The specimen was taken from a littermate of that in (M).
T11375 14948-14951 DT denotes The
T11376 14952-14960 NN denotes specimen
T11377 14965-14970 VBN denotes taken
T11378 14961-14964 VBD denotes was
T11379 14971-14975 IN denotes from
T11380 14976-14977 DT denotes a
T11381 14978-14988 NN denotes littermate
T11382 14989-14991 IN denotes of
T11383 14992-14996 DT denotes that
T11384 14997-14999 IN denotes in
T11385 15000-15001 -LRB- denotes (
T11386 15001-15002 NN denotes M
T11387 15002-15003 -RRB- denotes )
T11388 15003-15004 . denotes .
T11389 15004-15046 sentence denotes (M) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt testis.
T11390 15005-15006 -LRB- denotes (
T11391 15006-15007 LS denotes M
T11392 15039-15045 NN denotes testis
T11393 15007-15008 -RRB- denotes )
T11394 15009-15017 NN denotes Rec8Mei8
T11395 15018-15026 NN denotes Rec8Mei8
T11396 15017-15018 HYPH denotes /
T11397 15027-15035 NN denotes Trip13Gt
T11398 15036-15038 NN denotes Gt
T11399 15035-15036 HYPH denotes /
T11400 15045-15046 . denotes .
T11401 15046-15079 sentence denotes (N) Dmc1 −/− Trip13Gt/Gt testis.
T11402 15047-15048 -LRB- denotes (
T11403 15048-15049 LS denotes N
T11404 15072-15078 NN denotes testis
T11405 15049-15050 -RRB- denotes )
T11406 15051-15055 NN denotes Dmc1
T11407 15056-15057 SYM denotes −
T11408 15057-15058 HYPH denotes /
T11409 15058-15059 SYM denotes −
T11410 15060-15068 NN denotes Trip13Gt
T11411 15069-15071 NN denotes Gt
T11412 15068-15069 HYPH denotes /
T11413 15078-15079 . denotes .
T11414 15079-15120 sentence denotes (O) Spo11 −/− Trip13Gt/+ 25-d-old ovary.
T11415 15080-15081 -LRB- denotes (
T11416 15081-15082 LS denotes O
T11417 15114-15119 NN denotes ovary
T11418 15082-15083 -RRB- denotes )
T11419 15084-15089 NN denotes Spo11
T11420 15090-15091 SYM denotes −
T11421 15091-15092 HYPH denotes /
T11422 15092-15093 SYM denotes −
T11423 15094-15102 NN denotes Trip13Gt
T11424 15102-15103 HYPH denotes /
T11425 15103-15104 SYM denotes +
T11426 15105-15107 CD denotes 25
T11427 15108-15109 NN denotes d
T11428 15107-15108 HYPH denotes -
T11429 15110-15113 JJ denotes old
T11430 15109-15110 HYPH denotes -
T11431 15119-15120 . denotes .
T11432 15120-15177 sentence denotes The specimen was taken from a littermate of that in (P).
T11433 15121-15124 DT denotes The
T11434 15125-15133 NN denotes specimen
T11435 15138-15143 VBN denotes taken
T11436 15134-15137 VBD denotes was
T11437 15144-15148 IN denotes from
T11438 15149-15150 DT denotes a
T11439 15151-15161 NN denotes littermate
T11440 15162-15164 IN denotes of
T11441 15165-15169 DT denotes that
T11442 15170-15172 IN denotes in
T11443 15173-15174 -LRB- denotes (
T11444 15174-15175 NN denotes P
T11445 15175-15176 -RRB- denotes )
T11446 15176-15177 . denotes .
T11447 15177-15219 sentence denotes (P) Spo11 −/− Trip13Gt/Gt 25-d-old ovary.
T11448 15178-15179 -LRB- denotes (
T11449 15179-15180 LS denotes P
T11450 15213-15218 NN denotes ovary
T11451 15180-15181 -RRB- denotes )
T11452 15182-15187 NN denotes Spo11
T11453 15188-15189 SYM denotes −
T11454 15189-15190 HYPH denotes /
T11455 15190-15191 SYM denotes −
T11456 15192-15200 NN denotes Trip13Gt
T11457 15201-15203 NN denotes Gt
T11458 15200-15201 HYPH denotes /
T11459 15204-15206 CD denotes 25
T11460 15207-15208 NN denotes d
T11461 15206-15207 HYPH denotes -
T11462 15209-15212 JJ denotes old
T11463 15208-15209 HYPH denotes -
T11464 15218-15219 . denotes .
T11465 15219-15259 sentence denotes (Q) Mei1 −/− Trip13Gt/+ 25-d-old ovary.
T11466 15220-15221 -LRB- denotes (
T11467 15221-15222 LS denotes Q
T11468 15253-15258 NN denotes ovary
T11469 15222-15223 -RRB- denotes )
T11470 15224-15228 NN denotes Mei1
T11471 15229-15230 SYM denotes −
T11472 15230-15231 HYPH denotes /
T11473 15231-15232 SYM denotes −
T11474 15233-15241 NN denotes Trip13Gt
T11475 15241-15242 HYPH denotes /
T11476 15242-15243 SYM denotes +
T11477 15244-15246 CD denotes 25
T11478 15247-15248 NN denotes d
T11479 15246-15247 HYPH denotes -
T11480 15249-15252 JJ denotes old
T11481 15248-15249 HYPH denotes -
T11482 15258-15259 . denotes .
T11483 15259-15316 sentence denotes The specimen was taken from a littermate of that in (R).
T11484 15260-15263 DT denotes The
T11485 15264-15272 NN denotes specimen
T11486 15277-15282 VBN denotes taken
T11487 15273-15276 VBD denotes was
T11488 15283-15287 IN denotes from
T11489 15288-15289 DT denotes a
T11490 15290-15300 NN denotes littermate
T11491 15301-15303 IN denotes of
T11492 15304-15308 DT denotes that
T11493 15309-15311 IN denotes in
T11494 15312-15313 -LRB- denotes (
T11495 15313-15314 NN denotes R
T11496 15314-15315 -RRB- denotes )
T11497 15315-15316 . denotes .
T11498 15316-15357 sentence denotes (R) Mei1 −/− Trip13Gt/Gt 25-d-old ovary.
T11499 15317-15318 -LRB- denotes (
T11500 15318-15319 LS denotes R
T11501 15351-15356 NN denotes ovary
T11502 15319-15320 -RRB- denotes )
T11503 15321-15325 NN denotes Mei1
T11504 15326-15327 SYM denotes −
T11505 15327-15328 HYPH denotes /
T11506 15328-15329 SYM denotes −
T11507 15330-15338 NN denotes Trip13Gt
T11508 15339-15341 NN denotes Gt
T11509 15338-15339 HYPH denotes /
T11510 15342-15344 CD denotes 25
T11511 15345-15346 NN denotes d
T11512 15344-15345 HYPH denotes -
T11513 15347-15350 JJ denotes old
T11514 15346-15347 HYPH denotes -
T11515 15356-15357 . denotes .
T11516 15357-15406 sentence denotes (S) Rec8Mei8/Rec8Mei8 Trip13Gt/+ 25-d-old ovary.
T11517 15358-15359 -LRB- denotes (
T11518 15359-15360 LS denotes S
T11519 15400-15405 NN denotes ovary
T11520 15360-15361 -RRB- denotes )
T11521 15362-15370 NN denotes Rec8Mei8
T11522 15371-15379 NN denotes Rec8Mei8
T11523 15370-15371 HYPH denotes /
T11524 15380-15388 NN denotes Trip13Gt
T11525 15388-15389 HYPH denotes /
T11526 15389-15390 SYM denotes +
T11527 15391-15393 CD denotes 25
T11528 15394-15395 NN denotes d
T11529 15393-15394 HYPH denotes -
T11530 15396-15399 JJ denotes old
T11531 15395-15396 HYPH denotes -
T11532 15405-15406 . denotes .
T11533 15406-15463 sentence denotes The specimen was taken from a littermate of that in (T).
T11534 15407-15410 DT denotes The
T11535 15411-15419 NN denotes specimen
T11536 15424-15429 VBN denotes taken
T11537 15420-15423 VBD denotes was
T11538 15430-15434 IN denotes from
T11539 15435-15436 DT denotes a
T11540 15437-15447 NN denotes littermate
T11541 15448-15450 IN denotes of
T11542 15451-15455 DT denotes that
T11543 15456-15458 IN denotes in
T11544 15459-15460 -LRB- denotes (
T11545 15460-15461 NN denotes T
T11546 15461-15462 -RRB- denotes )
T11547 15462-15463 . denotes .
T11548 15463-15513 sentence denotes (T) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt 25-d-old ovary.
T11549 15464-15465 -LRB- denotes (
T11550 15465-15466 LS denotes T
T11551 15507-15512 NN denotes ovary
T11552 15466-15467 -RRB- denotes )
T11553 15468-15476 NN denotes Rec8Mei8
T11554 15477-15485 NN denotes Rec8Mei8
T11555 15476-15477 HYPH denotes /
T11556 15486-15494 NN denotes Trip13Gt
T11557 15495-15497 NN denotes Gt
T11558 15494-15495 HYPH denotes /
T11559 15498-15500 CD denotes 25
T11560 15501-15502 NN denotes d
T11561 15500-15501 HYPH denotes -
T11562 15503-15506 JJ denotes old
T11563 15502-15503 HYPH denotes -
T11564 15512-15513 . denotes .
T11701 17646-17665 JJ denotes Immunohistochemical
T11702 17666-17674 NN denotes Analysis
T11703 17675-17677 IN denotes of
T11704 17678-17687 NN denotes Pachytene
T11705 17701-17712 NNS denotes Chromosomes
T11706 17688-17700 NN denotes Spermatocyte
T11707 17712-17806 sentence denotes Surface-spread chromosomes were immunolabeled with the indicated antibodies and fluorophores.
T11708 17713-17720 NN denotes Surface
T11709 17721-17727 NN denotes spread
T11710 17720-17721 HYPH denotes -
T11711 17728-17739 NNS denotes chromosomes
T11712 17745-17758 VBN denotes immunolabeled
T11713 17740-17744 VBD denotes were
T11714 17759-17763 IN denotes with
T11715 17764-17767 DT denotes the
T11716 17778-17788 NNS denotes antibodies
T11717 17768-17777 VBN denotes indicated
T11718 17789-17792 CC denotes and
T11719 17793-17805 NNS denotes fluorophores
T11720 17805-17806 . denotes .
T11721 17806-17932 sentence denotes As indicated in the upper right of each panel, cells were from wild type (WT, either +/+ or Trip13Gt/+) or Trip13Gt/Gt (Mut).
T11722 17807-17809 IN denotes As
T11723 17810-17819 VBN denotes indicated
T11724 17860-17864 VBD denotes were
T11725 17820-17822 IN denotes in
T11726 17823-17826 DT denotes the
T11727 17833-17838 NN denotes right
T11728 17827-17832 JJ denotes upper
T11729 17839-17841 IN denotes of
T11730 17842-17846 DT denotes each
T11731 17847-17852 NN denotes panel
T11732 17852-17854 , denotes ,
T11733 17854-17859 NNS denotes cells
T11734 17865-17869 IN denotes from
T11735 17870-17874 JJ denotes wild
T11736 17875-17879 NN denotes type
T11737 17880-17881 -LRB- denotes (
T11738 17881-17883 NN denotes WT
T11739 17883-17885 , denotes ,
T11740 17885-17891 CC denotes either
T11741 17894-17895 SYM denotes +
T11742 17892-17893 SYM denotes +
T11743 17893-17894 HYPH denotes /
T11744 17896-17898 CC denotes or
T11745 17899-17907 NN denotes Trip13Gt
T11746 17907-17908 HYPH denotes /
T11747 17908-17909 SYM denotes +
T11748 17909-17910 -RRB- denotes )
T11749 17911-17913 CC denotes or
T11750 17914-17922 NN denotes Trip13Gt
T11751 17923-17925 NN denotes Gt
T11752 17922-17923 HYPH denotes /
T11753 17926-17927 -LRB- denotes (
T11754 17927-17930 NN denotes Mut
T11755 17930-17931 -RRB- denotes )
T11756 17931-17932 . denotes .
T11757 17932-18008 sentence denotes There were no differences seen between heterozygotes and +/+ spermatocytes.
T11758 17933-17938 EX denotes There
T11759 17939-17943 VBD denotes were
T11760 17944-17946 DT denotes no
T11761 17947-17958 NNS denotes differences
T11762 17959-17963 VBN denotes seen
T11763 17964-17971 IN denotes between
T11764 17972-17985 NNS denotes heterozygotes
T11765 17986-17989 CC denotes and
T11766 17990-17991 SYM denotes +
T11767 17992-17993 SYM denotes +
T11768 17991-17992 HYPH denotes /
T11769 17994-18007 NNS denotes spermatocytes
T11770 18007-18008 . denotes .
T11771 18008-18059 sentence denotes (A) A mutant pachytene nucleus with full synapsis.
T11772 18009-18010 -LRB- denotes (
T11773 18010-18011 LS denotes A
T11774 18032-18039 NN denotes nucleus
T11775 18011-18012 -RRB- denotes )
T11776 18013-18014 DT denotes A
T11777 18015-18021 NN denotes mutant
T11778 18022-18031 NN denotes pachytene
T11779 18040-18044 IN denotes with
T11780 18045-18049 JJ denotes full
T11781 18050-18058 NN denotes synapsis
T11782 18058-18059 . denotes .
T11783 18059-18103 sentence denotes Areas of SYCP1/SYCP3 colabeling are yellow.
T11784 18060-18065 NNS denotes Areas
T11785 18092-18095 VBP denotes are
T11786 18066-18068 IN denotes of
T11787 18069-18074 NN denotes SYCP1
T11788 18075-18080 NN denotes SYCP3
T11789 18074-18075 HYPH denotes /
T11790 18081-18091 NN denotes colabeling
T11791 18096-18102 JJ denotes yellow
T11792 18102-18103 . denotes .
T11793 18103-18162 sentence denotes (B–E) Spermatocytes nucleus from 17.5 d postpartum mutant.
T11794 18104-18105 -LRB- denotes (
T11795 18105-18106 LS denotes B
T11796 18124-18131 NN denotes nucleus
T11797 18106-18107 SYM denotes –
T11798 18107-18108 LS denotes E
T11799 18108-18109 -RRB- denotes )
T11800 18110-18123 NNS denotes Spermatocytes
T11801 18132-18136 IN denotes from
T11802 18137-18141 CD denotes 17.5
T11803 18142-18143 NN denotes d
T11804 18144-18154 JJ denotes postpartum
T11805 18155-18161 NN denotes mutant
T11806 18161-18162 . denotes .
T11807 18162-18266 sentence denotes Asynapsed chromosomes or regions of chromosomes are indicated by white and yellow arrows, respectively.
T11808 18163-18172 VBN denotes Asynapsed
T11809 18173-18184 NNS denotes chromosomes
T11810 18215-18224 VBN denotes indicated
T11811 18185-18187 CC denotes or
T11812 18188-18195 NNS denotes regions
T11813 18196-18198 IN denotes of
T11814 18199-18210 NNS denotes chromosomes
T11815 18211-18214 VBP denotes are
T11816 18225-18227 IN denotes by
T11817 18228-18233 JJ denotes white
T11818 18245-18251 NNS denotes arrows
T11819 18234-18237 CC denotes and
T11820 18238-18244 JJ denotes yellow
T11821 18251-18253 , denotes ,
T11822 18253-18265 RB denotes respectively
T11823 18265-18266 . denotes .
T11824 18266-18413 sentence denotes Unlike the normal distribution in wild-type pachytene spermatocytes (C), BLM foci are present on synapsed pachytene chromosomes in the mutant (D).
T11825 18267-18273 IN denotes Unlike
T11826 18349-18352 VBP denotes are
T11827 18274-18277 DT denotes the
T11828 18285-18297 NN denotes distribution
T11829 18278-18284 JJ denotes normal
T11830 18298-18300 IN denotes in
T11831 18301-18305 JJ denotes wild
T11832 18306-18310 NN denotes type
T11833 18305-18306 HYPH denotes -
T11834 18321-18334 NNS denotes spermatocytes
T11835 18311-18320 NN denotes pachytene
T11836 18335-18336 -LRB- denotes (
T11837 18336-18337 NN denotes C
T11838 18337-18338 -RRB- denotes )
T11839 18338-18340 , denotes ,
T11840 18340-18343 NN denotes BLM
T11841 18344-18348 NNS denotes foci
T11842 18353-18360 JJ denotes present
T11843 18361-18363 IN denotes on
T11844 18364-18372 VBN denotes synapsed
T11845 18383-18394 NNS denotes chromosomes
T11846 18373-18382 NN denotes pachytene
T11847 18395-18397 IN denotes in
T11848 18398-18401 DT denotes the
T11849 18402-18408 NN denotes mutant
T11850 18409-18410 -LRB- denotes (
T11851 18410-18411 NN denotes D
T11852 18411-18412 -RRB- denotes )
T11853 18412-18413 . denotes .
T11854 18413-18578 sentence denotes RAD51 foci, which are abundant earlier in prophase, disappear from autosomes in wild-type pachytene nuclei (E) and the bulk of staining is over the XY body (arrow).
T11855 18414-18419 NN denotes RAD51
T11856 18420-18424 NNS denotes foci
T11857 18466-18475 VBP denotes disappear
T11858 18424-18426 , denotes ,
T11859 18426-18431 WDT denotes which
T11860 18432-18435 VBP denotes are
T11861 18436-18444 JJ denotes abundant
T11862 18445-18452 RBR denotes earlier
T11863 18453-18455 IN denotes in
T11864 18456-18464 NN denotes prophase
T11865 18464-18466 , denotes ,
T11866 18476-18480 IN denotes from
T11867 18481-18490 NNS denotes autosomes
T11868 18491-18493 IN denotes in
T11869 18494-18498 JJ denotes wild
T11870 18499-18503 NN denotes type
T11871 18498-18499 HYPH denotes -
T11872 18514-18520 NNS denotes nuclei
T11873 18504-18513 NN denotes pachytene
T11874 18521-18522 -LRB- denotes (
T11875 18522-18523 NN denotes E
T11876 18523-18524 -RRB- denotes )
T11877 18525-18528 CC denotes and
T11878 18529-18532 DT denotes the
T11879 18533-18537 NN denotes bulk
T11880 18550-18552 VBZ denotes is
T11881 18538-18540 IN denotes of
T11882 18541-18549 NN denotes staining
T11883 18553-18557 IN denotes over
T11884 18558-18561 DT denotes the
T11885 18565-18569 NN denotes body
T11886 18562-18564 NN denotes XY
T11887 18570-18571 -LRB- denotes (
T11888 18571-18576 NN denotes arrow
T11889 18576-18577 -RRB- denotes )
T11890 18577-18578 . denotes .
T11891 18578-18642 sentence denotes (F) RAD51 persists on the synapsed mutant chromosomes (arrows).
T11892 18579-18580 -LRB- denotes (
T11893 18580-18581 LS denotes F
T11894 18589-18597 VBZ denotes persists
T11895 18581-18582 -RRB- denotes )
T11896 18583-18588 NN denotes RAD51
T11897 18598-18600 IN denotes on
T11898 18601-18604 DT denotes the
T11899 18621-18632 NNS denotes chromosomes
T11900 18605-18613 VBN denotes synapsed
T11901 18614-18620 NN denotes mutant
T11902 18633-18634 -LRB- denotes (
T11903 18634-18640 NNS denotes arrows
T11904 18640-18641 -RRB- denotes )
T11905 18641-18642 . denotes .
T11906 18642-18703 sentence denotes (G) H2AX phosphorylation is restricted to the XY body in WT.
T11907 18643-18644 -LRB- denotes (
T11908 18644-18645 LS denotes G
T11909 18671-18681 VBN denotes restricted
T11910 18645-18646 -RRB- denotes )
T11911 18647-18651 NN denotes H2AX
T11912 18652-18667 NN denotes phosphorylation
T11913 18668-18670 VBZ denotes is
T11914 18682-18684 IN denotes to
T11915 18685-18688 DT denotes the
T11916 18692-18696 NN denotes body
T11917 18689-18691 NN denotes XY
T11918 18697-18699 IN denotes in
T11919 18700-18702 NN denotes WT
T11920 18702-18703 . denotes .
T11921 18703-18839 sentence denotes (H) In addition to a large area of γH2AX staining (arrow) over the XY body, there is extensive autosomal H2AX phosphorylation (arrows).
T11922 18704-18705 -LRB- denotes (
T11923 18705-18706 LS denotes H
T11924 18786-18788 VBZ denotes is
T11925 18706-18707 -RRB- denotes )
T11926 18708-18710 IN denotes In
T11927 18711-18719 NN denotes addition
T11928 18720-18722 IN denotes to
T11929 18723-18724 DT denotes a
T11930 18731-18735 NN denotes area
T11931 18725-18730 JJ denotes large
T11932 18736-18738 IN denotes of
T11933 18739-18744 NN denotes γH2AX
T11934 18745-18753 NN denotes staining
T11935 18754-18755 -LRB- denotes (
T11936 18755-18760 NN denotes arrow
T11937 18760-18761 -RRB- denotes )
T11938 18762-18766 IN denotes over
T11939 18767-18770 DT denotes the
T11940 18774-18778 NN denotes body
T11941 18771-18773 NN denotes XY
T11942 18778-18780 , denotes ,
T11943 18780-18785 EX denotes there
T11944 18789-18798 JJ denotes extensive
T11945 18814-18829 NN denotes phosphorylation
T11946 18799-18808 JJ denotes autosomal
T11947 18809-18813 NN denotes H2AX
T11948 18830-18831 -LRB- denotes (
T11949 18831-18837 NNS denotes arrows
T11950 18837-18838 -RRB- denotes )
T11951 18838-18839 . denotes .
T11952 18839-18950 sentence denotes (I, J) Note that in wild-type pachytene spermatocytes, TOPBP1 is present only over the XY body (yellow arrow).
T11953 18840-18841 -LRB- denotes (
T11954 18841-18842 LS denotes I
T11955 18847-18851 VB denotes Note
T11956 18842-18844 , denotes ,
T11957 18844-18845 LS denotes J
T11958 18845-18846 -RRB- denotes )
T11959 18852-18856 IN denotes that
T11960 18902-18904 VBZ denotes is
T11961 18857-18859 IN denotes in
T11962 18860-18864 JJ denotes wild
T11963 18865-18869 NN denotes type
T11964 18864-18865 HYPH denotes -
T11965 18880-18893 NNS denotes spermatocytes
T11966 18870-18879 NN denotes pachytene
T11967 18893-18895 , denotes ,
T11968 18895-18901 NN denotes TOPBP1
T11969 18905-18912 JJ denotes present
T11970 18913-18917 RB denotes only
T11971 18918-18922 IN denotes over
T11972 18923-18926 DT denotes the
T11973 18930-18934 NN denotes body
T11974 18927-18929 NN denotes XY
T11975 18935-18936 -LRB- denotes (
T11976 18943-18948 NN denotes arrow
T11977 18936-18942 JJ denotes yellow
T11978 18948-18949 -RRB- denotes )
T11979 18949-18950 . denotes .
T11980 18950-19111 sentence denotes In the mutant (J), an arrow denotes one area of intensive staining that may be over the sex chromosomes, but many other chromosome cores are positively stained.
T11981 18951-18953 IN denotes In
T11982 18979-18986 VBZ denotes denotes
T11983 18954-18957 DT denotes the
T11984 18958-18964 NN denotes mutant
T11985 18965-18966 -LRB- denotes (
T11986 18966-18967 NN denotes J
T11987 18967-18968 -RRB- denotes )
T11988 18968-18970 , denotes ,
T11989 18970-18972 DT denotes an
T11990 18973-18978 NN denotes arrow
T11991 18987-18990 CD denotes one
T11992 18991-18995 NN denotes area
T11993 18996-18998 IN denotes of
T11994 18999-19008 JJ denotes intensive
T11995 19009-19017 NN denotes staining
T11996 19018-19022 WDT denotes that
T11997 19027-19029 VB denotes be
T11998 19023-19026 MD denotes may
T11999 19030-19034 IN denotes over
T12000 19035-19038 DT denotes the
T12001 19043-19054 NNS denotes chromosomes
T12002 19039-19042 NN denotes sex
T12003 19054-19056 , denotes ,
T12004 19056-19059 CC denotes but
T12005 19060-19064 JJ denotes many
T12006 19082-19087 NNS denotes cores
T12007 19065-19070 JJ denotes other
T12008 19071-19081 NN denotes chromosome
T12009 19103-19110 VBN denotes stained
T12010 19088-19091 VBP denotes are
T12011 19092-19102 RB denotes positively
T12012 19110-19111 . denotes .
T12013 19111-19175 sentence denotes (K, L) RPA persists along synapsed cores in the mutant, not WT.
T12014 19112-19113 -LRB- denotes (
T12015 19113-19114 LS denotes K
T12016 19123-19131 VBZ denotes persists
T12017 19114-19116 , denotes ,
T12018 19116-19117 LS denotes L
T12019 19117-19118 -RRB- denotes )
T12020 19119-19122 NN denotes RPA
T12021 19132-19137 IN denotes along
T12022 19138-19146 VBN denotes synapsed
T12023 19147-19152 NNS denotes cores
T12024 19153-19155 IN denotes in
T12025 19156-19159 DT denotes the
T12026 19160-19166 NN denotes mutant
T12027 19166-19168 , denotes ,
T12028 19168-19171 CC denotes not
T12029 19172-19174 NN denotes WT
T12030 19174-19175 . denotes .
T12031 19175-19228 sentence denotes (M, N) Arrows indicate examples of MLH3 foci on SCs.
T12032 19176-19177 -LRB- denotes (
T12033 19177-19178 LS denotes M
T12034 19190-19198 VBP denotes indicate
T12035 19178-19180 , denotes ,
T12036 19180-19181 LS denotes N
T12037 19181-19182 -RRB- denotes )
T12038 19183-19189 NNS denotes Arrows
T12039 19199-19207 NNS denotes examples
T12040 19208-19210 IN denotes of
T12041 19211-19215 NN denotes MLH3
T12042 19216-19220 NNS denotes foci
T12043 19221-19223 IN denotes on
T12044 19224-19227 NNS denotes SCs
T12045 19227-19228 . denotes .
T12046 19228-19312 sentence denotes (O) In WT late pachytene spermatocytes, RAD51 is present only at background levels.
T12047 19229-19230 -LRB- denotes (
T12048 19230-19231 LS denotes O
T12049 19275-19277 VBZ denotes is
T12050 19231-19232 -RRB- denotes )
T12051 19233-19235 IN denotes In
T12052 19236-19238 NN denotes WT
T12053 19254-19267 NNS denotes spermatocytes
T12054 19239-19243 JJ denotes late
T12055 19244-19253 NN denotes pachytene
T12056 19267-19269 , denotes ,
T12057 19269-19274 NN denotes RAD51
T12058 19278-19285 JJ denotes present
T12059 19286-19290 RB denotes only
T12060 19291-19293 IN denotes at
T12061 19294-19304 NN denotes background
T12062 19305-19311 NNS denotes levels
T12063 19311-19312 . denotes .
T12064 19312-19421 sentence denotes (P) As in (F), extensive RAD51 staining delineates SCs in mutant pachytene nuclei (indicated by white arcs).
T12065 19313-19314 -LRB- denotes (
T12066 19314-19315 LS denotes P
T12067 19353-19363 VBZ denotes delineates
T12068 19315-19316 -RRB- denotes )
T12069 19317-19319 IN denotes As
T12070 19320-19322 IN denotes in
T12071 19323-19324 -LRB- denotes (
T12072 19324-19325 NN denotes F
T12073 19325-19326 -RRB- denotes )
T12074 19326-19328 , denotes ,
T12075 19328-19337 JJ denotes extensive
T12076 19344-19352 NN denotes staining
T12077 19338-19343 NN denotes RAD51
T12078 19364-19367 NNS denotes SCs
T12079 19368-19370 IN denotes in
T12080 19371-19377 NN denotes mutant
T12081 19388-19394 NNS denotes nuclei
T12082 19378-19387 NN denotes pachytene
T12083 19395-19396 -LRB- denotes (
T12084 19396-19405 VBN denotes indicated
T12085 19406-19408 IN denotes by
T12086 19409-19414 JJ denotes white
T12087 19415-19419 NNS denotes arcs
T12088 19419-19420 -RRB- denotes )
T12089 19420-19421 . denotes .
T12090 19421-19519 sentence denotes MLH1 foci colocalize with these tracts (arrows) at the typical 1–2 foci per chromosome as in (M).
T12091 19422-19426 NN denotes MLH1
T12092 19427-19431 NNS denotes foci
T12093 19432-19442 VBP denotes colocalize
T12094 19443-19447 IN denotes with
T12095 19448-19453 DT denotes these
T12096 19454-19460 NNS denotes tracts
T12097 19461-19462 -LRB- denotes (
T12098 19462-19468 NNS denotes arrows
T12099 19468-19469 -RRB- denotes )
T12100 19470-19472 IN denotes at
T12101 19473-19476 DT denotes the
T12102 19489-19493 NNS denotes foci
T12103 19477-19484 JJ denotes typical
T12104 19485-19486 CD denotes 1
T12105 19487-19488 CD denotes 2
T12106 19486-19487 SYM denotes –
T12107 19494-19497 IN denotes per
T12108 19498-19508 NN denotes chromosome
T12109 19509-19511 IN denotes as
T12110 19512-19514 IN denotes in
T12111 19515-19516 -LRB- denotes (
T12112 19516-19517 NN denotes M
T12113 19517-19518 -RRB- denotes )
T12114 19518-19519 . denotes .
T12149 27162-27165 VBP denotes are
T12150 27175-27177 , denotes ,
T12151 27177-27179 IN denotes as
T12152 27180-27183 VBP denotes are
T12153 27184-27189 DT denotes those
T12154 27190-27196 NNS denotes panels
T12155 27197-27199 IN denotes in
T12156 27233-27239 VBN denotes merged
T12157 27200-27205 WDT denotes which
T12158 27206-27210 JJ denotes dual
T12159 27220-27228 NNS denotes patterns
T12160 27211-27219 NN denotes staining
T12161 27229-27232 VBP denotes are
T12162 27239-27240 . denotes .
T12163 27240-27314 sentence denotes Note that (H) and (I) are at lower magnification to show multiple nuclei.
T12164 27241-27245 VB denotes Note
T12165 27246-27250 IN denotes that
T12166 27263-27266 VBP denotes are
T12167 27251-27252 -LRB- denotes (
T12168 27252-27253 NN denotes H
T12169 27253-27254 -RRB- denotes )
T12170 27255-27258 CC denotes and
T12171 27259-27260 -LRB- denotes (
T12172 27260-27261 NN denotes I
T12173 27261-27262 -RRB- denotes )
T12174 27267-27269 IN denotes at
T12175 27270-27275 JJR denotes lower
T12176 27276-27289 NN denotes magnification
T12177 27290-27292 TO denotes to
T12178 27293-27297 VB denotes show
T12179 27298-27306 JJ denotes multiple
T12180 27307-27313 NNS denotes nuclei
T12181 27313-27314 . denotes .
T5198 26840-26850 NN denotes vertebrate
T5199 26851-26859 JJ denotes specific
T5200 26850-26851 HYPH denotes -
T12126 27004-27021 JJ denotes Immunocytological
T12127 27022-27030 NN denotes Analysis
T12128 27031-27033 IN denotes of
T12129 27034-27040 NN denotes Trip13
T12130 27050-27057 NNS denotes Mutants
T12131 27041-27049 NN denotes Compound
T12132 27057-27151 sentence denotes Surface-spread chromosomes were immunolabeled with the indicated antibodies and fluorophores.
T12133 27058-27065 NN denotes Surface
T12134 27066-27072 NN denotes spread
T12135 27065-27066 HYPH denotes -
T12136 27073-27084 NNS denotes chromosomes
T12137 27090-27103 VBN denotes immunolabeled
T12138 27085-27089 VBD denotes were
T12139 27104-27108 IN denotes with
T12140 27109-27112 DT denotes the
T12141 27123-27133 NNS denotes antibodies
T12142 27113-27122 VBN denotes indicated
T12143 27134-27137 CC denotes and
T12144 27138-27150 NNS denotes fluorophores
T12145 27150-27151 . denotes .
T12146 27151-27240 sentence denotes Genotypes are indicated, as are those panels in which dual staining patterns are merged.
T12147 27152-27161 NNS denotes Genotypes
T12148 27166-27175 VBN denotes indicated
T5201 26865-26869 RB denotes also
T5202 26870-26878 VBN denotes required
T5203 26879-26882 IN denotes for
T5204 26883-26886 NN denotes DSB
T138 0-5 NN denotes Mouse
T139 16-26 NN denotes Checkpoint
T5205 26887-26896 NN denotes formation
T5206 26897-26900 CC denotes and
T2441 13686-13690 DT denotes this
T2442 13701-13705 IN denotes that
T2443 13719-13729 VBN denotes eliminated
T2444 13706-13713 NNS denotes oocytes
T2445 13714-13718 VBD denotes were
T2446 13730-13739 RB denotes somewhere
T2447 13740-13747 IN denotes between
T2448 13748-13757 NN denotes pachynema
T2449 13758-13761 CC denotes and
T2450 13762-13770 NN denotes dictyate
T2451 13770-13771 . denotes .
T2452 13771-15665 sentence denotes Figure 3 Histology of Mutant Gonads All are hematoxylin/eosin-stained paraffin sections. Testes are from 6-wk-old males, except as indicated below. (A) Wild-type 25-d-old ovary. (B) Trip13Gt /Gt 25-d-old ovary, showing dysgenesis from an absence of oocytes. (C) Trip13Gt/+ 2-d-old control ovary. Arrows point to oocytes in newly forming follicles. (D) Trip13Gt/Gt 2-d-old ovary, dysgenic due to lack of oocytes. Magnification is the same as its littermate in “C.” (E) Wild-type testis. (F) Trip13Gt/Gt testis with uniform pachytene arrest. (G) Trip13Gt/Gt 3-mo-old testis with some postmeiotic spermatids (arrows). (H) Spo11−/- testis. A tubule with spermatocytes at leptotene/zygotene transition is labeled ZP, and tubules with apoptotic spermatocytes are marked with an asterisk. The specimen was taken from a littermate of that in (I). (I) Spo11 −/− Trip13Gt/Gt testis. Labeling is the same as in (H). The inset contains a tubule with leptotene-zygotene spermatocytes. (J) Mei1 −/− Trip13Gt/+ testis. The specimen was taken from a littermate of that in (K). (K) Mei1 −/− Trip13Gt/Gt testis. (L) Rec8Mei8/Rec8Mei8 Trip13Gt/+ testis. The Rec8Mei8 allele was described [39]. The specimen was taken from a littermate of that in (M). (M) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt testis. (N) Dmc1 −/− Trip13Gt/Gt testis. (O) Spo11 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (P). (P) Spo11 −/− Trip13Gt/Gt 25-d-old ovary. (Q) Mei1 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (R). (R) Mei1 −/− Trip13Gt/Gt 25-d-old ovary. (S) Rec8Mei8/Rec8Mei8 Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (T). (T) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt 25-d-old ovary. Histological sections of mutant testes revealed a lack of postmeiotic cell types that are characteristic of wild-type seminiferous tubules (Figure 3E).
T2453 15514-15526 JJ denotes Histological
T2454 15527-15535 NNS denotes sections
T2455 15553-15561 VBD denotes revealed
T5207 26901-26911 NN denotes chromosome
T5208 26912-26920 NN denotes synapsis
T5209 26921-26922 -LRB- denotes [
T1847 10247-10260 JJ denotes semi-congenic
T1848 10261-10262 -LRB- denotes (
T1849 10262-10264 NN denotes N4
T1850 10264-10265 -RRB- denotes )
T1851 10266-10268 IN denotes on
T1852 10269-10272 DT denotes the
T1853 10282-10288 NN denotes strain
T1854 10273-10278 NN denotes C57BL
T1855 10279-10281 NN denotes 6J
T1856 10278-10279 HYPH denotes /
T1857 10294-10299 RB denotes often
T1858 10300-10308 RB denotes markedly
T1859 10309-10316 JJR denotes smaller
T1860 10317-10320 CC denotes and
T1861 10320-10321 HYPH denotes /
T1862 10321-10323 CC denotes or
T1863 10324-10327 VBD denotes had
T1864 10328-10334 VBN denotes kinked
T1865 10346-10351 NNS denotes tails
T1866 10335-10337 CC denotes or
T1867 10338-10345 JJR denotes shorter
T1868 10352-10353 -LRB- denotes (
T1869 10360-10362 NN denotes 2A
T1870 10353-10359 NN denotes Figure
T1871 10363-10366 CC denotes and
T1872 10367-10369 NN denotes 2B
T1873 10369-10370 -RRB- denotes )
T1874 10370-10371 . denotes .
T1875 10371-10372 sentence denotes
T5210 26922-26924 CD denotes 37
T1876 11173-11390 sentence denotes RT-PCR analysis of Trip13Gt expression (Figure 1D) revealed a low level of normally spliced transcripts in testes of homozygotes that is presumably a consequence of incomplete usage of the gene trap's splice acceptor.
T1877 11173-11175 NN denotes RT
T5211 26924-26925 -RRB- denotes ]
T5212 26925-26927 , denotes ,
T5213 26927-26931 IN denotes with
T5193 26828-26831 IN denotes for
T5194 26832-26836 NN denotes Mei1
T5195 26836-26838 , denotes ,
T5196 26838-26839 DT denotes a
T5197 26860-26864 NN denotes gene
T5214 26932-26939 JJ denotes similar
T5215 26940-26947 NNS denotes results
T5216 26948-26949 -LRB- denotes (
T5217 26956-26958 NN denotes 3J
T5218 26949-26955 NN denotes Figure
T5219 26959-26962 CC denotes and
T5220 26963-26965 NN denotes 3K
T5221 26965-26966 : denotes ;
T5222 26967-26981 NN denotes immunocytology
T5223 26986-26991 VBN denotes shown
T5224 26982-26985 RB denotes not
T5225 26991-26992 -RRB- denotes )
T5226 26992-26993 . denotes .
T5227 26993-26994 sentence denotes
T5228 27315-27319 sentence denotes In y
T5229 27315-27317 JJ denotes In
T5230 27318-27319 NN denotes y
T5231 27319-27323 sentence denotes east
T5232 27319-27320 NN denotes e
T5233 27320-27321 NN denotes a
T5234 27321-27322 NNS denotes s
T3112 17150-17152 , denotes ,
T3113 17152-17164 RB denotes respectively
T3114 17164-17165 : denotes ;
T3115 17166-17172 NN denotes Figure
T3116 17175-17176 -RRB- denotes )
T3117 17176-17177 . denotes .
T3118 17177-17346 sentence denotes We attribute this to a delay in the first wave of postnatal spermatogenesis (Figure 2D and 2E), likely related to systemic developmental retardation (Figure 2A and 2B).
T3119 17178-17180 PRP denotes We
T3120 17181-17190 VBP denotes attribute
T3121 17191-17195 DT denotes this
T3122 17196-17198 IN denotes to
T3123 17199-17200 DT denotes a
T3124 17201-17206 NN denotes delay
T3203 19520-19523 sentence denotes To
T3204 19520-19521 NN denotes T
T3205 19521-19522 CC denotes o
T3206 19523-19524 sentence denotes e
T3207 19523-19524 EX denotes e
T3208 19524-19526 sentence denotes lu
T3209 19524-19526 NN denotes lu
T3210 19526-19528 sentence denotes ci
T3211 19526-19528 NN denotes ci
T3212 19528-19531 sentence denotes dat
T3213 19528-19529 NN denotes d
T3214 19529-19531 JJ denotes at
T3215 19531-19538 sentence denotes e the c
T3216 19531-19532 VBN denotes e
T3217 19533-19534 VBN denotes t
T3218 19534-19536 JJ denotes he
T3219 19537-19538 RB denotes c
T3220 19538-19544 sentence denotes ause o
T3221 19539-19540 NN denotes u
T3222 19538-19539 JJ denotes a
T3223 19540-19542 NNS denotes se
T3224 19543-19544 NNS denotes o
T3225 19544-19552 sentence denotes f meioti
T3226 19544-19545 NNS denotes f
T3227 19545-19546 , denotes
T3228 19546-19547 IN denotes m
T3229 19547-19548 NNS denotes e
T3230 19548-19549 IN denotes i
T3231 19549-19550 IN denotes o
T3232 19550-19552 NN denotes ti
T3233 19552-19557 sentence denotes c arr
T3234 19552-19553 NNS denotes c
T3235 19554-19557 NNS denotes arr
T3236 19557-19560 sentence denotes est
T3237 19557-19560 VBN denotes est
T3238 19560-19563 sentence denotes , w
T3239 19560-19562 , denotes ,
T3240 19562-19563 NNS denotes w
T3241 19563-19570 sentence denotes e analy
T3242 19563-19564 VB denotes e
T3243 19565-19566 IN denotes a
T3244 19566-19567 IN denotes n
T3245 19567-19568 NN denotes a
T3246 19568-19570 RB denotes ly
T3247 19570-19572 sentence denotes ze
T3248 19570-19572 VBP denotes ze
T3249 19572-19670 sentence denotes d meiotic chromosomes with a variety of markers that are diagnostic of recombination and synapsis.
T3250 19572-19573 VB denotes d
T3251 19574-19581 JJ denotes meiotic
T3252 19582-19583 JJ denotes c
T3253 19583-19593 NNS denotes hromosomes
T3254 19594-19598 IN denotes with
T3255 19599-19600 DT denotes a
T3256 19601-19608 NN denotes variety
T3257 19609-19611 IN denotes of
T8077 38921-38923 IN denotes in
T8078 38924-38929 NN denotes yeast
T8079 38929-38931 , denotes ,
T8080 38931-38935 JJ denotes such
T8081 38936-38941 NNS denotes genes
T8082 38942-38947 RB denotes often
T8083 38953-38960 JJ denotes mitotic
T8084 38961-38970 NNS denotes functions
T8085 38971-38972 -LRB- denotes (
T8086 38972-38976 JJ denotes such
T8087 38977-38979 IN denotes as
T8088 38980-38985 NN denotes RAD24
T8089 38986-38987 -LRB- denotes [
T8090 38987-38988 CD denotes 7
T8091 38988-38989 -RRB- denotes ]
T8092 38989-38990 -RRB- denotes )
T8093 38990-38992 , denotes ,
T8094 38992-38995 CC denotes and
T8095 38996-39001 PRP$ denotes their
T8096 39002-39010 NN denotes ablation
T8097 39015-39020 VB denotes cause
T8098 39011-39014 MD denotes can
T8099 39021-39030 NN denotes lethality
T8100 39031-39032 -LRB- denotes [
T8101 39032-39034 CD denotes 42
T8102 39034-39035 -RRB- denotes ]
T8103 39035-39036 . denotes .
T8104 39036-39198 sentence denotes Unless mammalian pachytene checkpoint components have orthologs with similar functions in organisms such as yeast, their identities are likely to remain elusive.
T8105 39037-39043 IN denotes Unless
T8106 39086-39090 VBP denotes have
T8107 39044-39053 JJ denotes mammalian
T8108 39075-39085 NNS denotes components
T8109 39054-39063 NN denotes pachytene
T8110 39064-39074 NN denotes checkpoint
T8111 39169-39172 VBP denotes are
T8112 39091-39100 NNS denotes orthologs
T8113 39101-39105 IN denotes with
T8114 39106-39113 JJ denotes similar
R680 T1124 T1125 mark if,so
R681 T1125 T1126 advcl so,be
R682 T1126 T1109 conj be,is
R683 T1127 T1126 punct ", ",be
R684 T1128 T1126 mark whether,be
R685 T1129 T1126 nsubj it,be
R686 T1130 T1126 aux would,be
R687 T1131 T1126 acomp identical,be
R688 T1132 T1131 prep to,identical
R689 T1133 T1132 pobj that,to
R690 T1134 T1133 acl used,that
R691 T1135 T1134 prep in,used
R692 T1136 T1137 amod somatic,cells
R693 T1137 T1135 pobj cells,in
R694 T1138 T1078 punct .,remained
R695 T1140 T1141 det The,mechanisms
R696 T1141 T1142 nsubj mechanisms,remain
R697 T1143 T1141 prep of,mechanisms
R698 T1144 T1145 amod putative,control
R699 T1145 T1143 pobj control,of
R700 T1146 T1147 compound pachytene,checkpoint
R701 T1147 T1145 compound checkpoint,control
R702 T1148 T1142 acomp unknown,remain
R703 T1149 T1142 prep in,remain
R704 T1150 T1149 pobj mammals,in
R705 T1151 T1142 punct ", ",remain
R706 T1152 T1153 mark since,identified
R707 T1153 T1142 advcl identified,remain
R708 T1154 T1155 det no,mutations
R709 T1155 T1153 nsubjpass mutations,identified
R710 T1156 T1153 aux have,identified
R711 T1157 T1153 auxpass been,identified
R712 T1158 T1159 dep that,abolish
R791 T1241 T1236 conj meiosis,meiosis
R792 T1242 T1229 punct ", ",are
R793 T1243 T1229 advcl prompting,are
R794 T1244 T1245 det the,suggestion
R795 T1245 T1243 dobj suggestion,prompting
R796 T1246 T1247 mark that,evolved
R797 T1247 T1245 acl evolved,suggestion
R798 T1248 T1249 det a,checkpoint
R799 T1249 T1247 nsubj checkpoint,evolved
R800 T1250 T1251 npadvmod Pch2,dependent
R801 T1251 T1249 amod dependent,checkpoint
R819 T1270 T1271 advmod Here,generated
R820 T1272 T1271 punct ", ",generated
R821 T1273 T1271 nsubj we,generated
R849 T1303 T1300 advcl found,uncover
R921 T1452 T1451 cc and,yeast
R922 T1453 T1451 conj worm,yeast
R923 T1454 T1455 punct (,S1
R924 T1455 T1424 parataxis S1,encodes
R925 T1456 T1455 compound Figure,S1
R3 T141 T139 compound Pachytene,Checkpoint
R21 T162 T157 nsubjpass synapsis,coupled
R22 T163 T162 compound chromosome,synapsis
R45 T190 T188 ccomp required,report
R46 T191 T192 det the,ortholog
R48 T193 T192 compound mouse,ortholog
R49 T194 T192 punct (,ortholog
R50 T195 T192 appos Trip13,ortholog
R51 T196 T192 punct ),ortholog
R52 T197 T192 prep of,ortholog
R53 T198 T199 compound pachytene,checkpoint
R54 T199 T197 pobj checkpoint,of
R55 T200 T199 nummod 2,checkpoint
R56 T201 T199 punct (,checkpoint
R57 T202 T199 appos PCH2,checkpoint
R58 T203 T192 punct ),ortholog
R59 T204 T192 punct ", ",ortholog
R60 T205 T206 det an,component
R62 T207 T206 amod essential,component
R63 T208 T206 prep of,component
R64 T209 T210 det the,checkpoint
R66 T211 T210 compound synapsis,checkpoint
R67 T212 T210 prep in,checkpoint
R68 T213 T214 compound Saccharomyces,cerevisiae
R69 T214 T212 pobj cerevisiae,in
R70 T215 T214 cc and,cerevisiae
R71 T216 T217 compound Caenorhabditis,elegans
R72 T217 T214 conj elegans,cerevisiae
R73 T218 T190 punct ", ",required
R74 T219 T190 auxpass is,required
R84 T230 T232 amod deficient,mice
R85 T231 T230 punct -,deficient
R125 T276 T273 dobj MLH1,exhibited
R126 T277 T276 compound chiasmata,MLH1
R127 T278 T276 compound markers,MLH1
R133 T284 T286 nsubj treatment,caused
R134 T285 T284 compound acid,treatment
R135 T286 T273 conj caused,exhibited
R136 T287 T284 prep of,treatment
R137 T288 T289 compound mutant,spermatocytes
R138 T289 T287 pobj spermatocytes,of
R148 T300 T302 nsubj analysis,demonstrated
R149 T301 T300 compound mutant,analysis
R151 T304 T302 ccomp are,demonstrated
R152 T305 T306 det the,genes
R153 T306 T304 nsubj genes,are
R154 T307 T306 nmod recombination,genes
R155 T308 T307 cc and,recombination
R156 T309 T307 conj synapsis,recombination
R157 T310 T306 appos Spo11,genes
R158 T311 T310 punct ", ",Spo11
R159 T312 T310 conj Mei1,Spo11
R160 T313 T312 punct ", ",Mei1
R161 T314 T312 conj Rec8,Mei1
R162 T315 T314 punct ", ",Rec8
R163 T316 T314 cc and,Rec8
R164 T317 T314 conj Dmc1,Rec8
R172 T325 T323 ccomp have,suggesting
R173 T326 T325 nsubj TRIP13,have
R174 T327 T325 aux does,have
R175 T328 T325 neg not,have
R177 T330 T325 dobj function,have
R178 T331 T330 compound checkpoint,function
R185 T340 T338 ccomp required,indicate
R186 T341 T340 nsubjpass TRIP13,required
R187 T342 T340 auxpass is,required
R214 T371 T365 attr model,is
R215 T372 T371 amod first,model
R229 T386 T384 dobj evidence,provides
R230 T387 T386 amod first,evidence
R232 T389 T386 acl trigger,evidence
R233 T390 T391 amod unrepaired,damage
R235 T392 T391 compound DNA,damage
R236 T393 T391 advmod alone,damage
R237 T394 T389 aux can,trigger
R239 T396 T389 dobj response,trigger
R240 T397 T396 compound pachytene,response
R241 T398 T396 compound checkpoint,response
R245 T138 T139 compound Mouse,Checkpoint
R246 T139 T142 nsubjpass Checkpoint,Required
R251 T668 T669 det The,genesis
R252 T669 T670 nsubj genesis,is
R253 T671 T669 prep of,genesis
R254 T672 T671 pobj gametes,of
R255 T673 T672 acl containing,gametes
R256 T674 T675 det an,genome
R257 T675 T673 dobj genome,containing
R258 T676 T675 amod intact,genome
R259 T677 T675 punct ", ",genome
R260 T678 T675 amod haploid,genome
R261 T679 T670 acomp critical,is
R262 T680 T679 prep for,critical
R263 T681 T682 det the,prevention
R264 T682 T680 pobj prevention,for
R265 T683 T682 prep of,prevention
R266 T684 T685 compound birth,defects
R267 T685 T683 pobj defects,of
R268 T686 T670 punct ", ",is
R269 T687 T670 cc and,is
R270 T688 T670 conj is,is
R271 T689 T690 advmod highly,dependent
R272 T690 T688 acomp dependent,is
R273 T691 T690 prep upon,dependent
R274 T692 T693 det the,fidelity
R275 T693 T691 pobj fidelity,upon
R276 T694 T693 prep of,fidelity
R277 T695 T696 compound chromosome,dynamics
R278 T696 T694 pobj dynamics,of
R279 T697 T688 prep before,is
R280 T698 T699 det the,division
R281 T699 T697 pobj division,before
R282 T700 T699 amod first,division
R283 T701 T699 amod meiotic,division
R284 T702 T670 punct .,is
R285 T704 T705 amod Homologous,chromosomes
R286 T705 T706 nsubj chromosomes,pair
R287 T707 T706 aux must,pair
R288 T708 T706 punct ", ",pair
R289 T709 T706 conj synapse,pair
R290 T710 T709 punct ", ",synapse
R291 T711 T709 conj undergo,synapse
R292 T712 T711 dobj recombination,undergo
R293 T713 T711 punct ", ",undergo
R294 T714 T711 cc and,undergo
R295 T715 T711 conj segregate,undergo
R296 T716 T715 advmod properly,segregate
R297 T717 T715 prep to,segregate
R298 T718 T719 amod opposite,poles
R299 T719 T717 pobj poles,to
R300 T720 T706 punct .,pair
R301 T722 T723 nsubjpass Recombination,coupled
R302 T724 T722 punct ", ",Recombination
R303 T725 T726 dep which,repairs
R304 T726 T722 relcl repairs,Recombination
R305 T727 T728 nmod repair,breaks
R306 T728 T726 dobj breaks,repairs
R307 T729 T730 amod double,strand
R308 T730 T728 compound strand,breaks
R309 T731 T728 punct (,breaks
R310 T732 T728 appos DSBs,breaks
R311 T733 T728 punct ),breaks
R312 T734 T735 dep that,induced
R313 T735 T728 relcl induced,breaks
R314 T736 T735 auxpass are,induced
R315 T737 T735 advmod genetically,induced
R316 T738 T726 prep in,repairs
R317 T739 T738 pobj leptonema,in
R318 T740 T723 punct ", ",coupled
R319 T741 T723 auxpass is,coupled
R320 T742 T723 prep with,coupled
R321 T743 T742 pobj synapsis,with
R322 T744 T723 prep in,coupled
R323 T745 T746 amod budding,yeast
R324 T746 T744 pobj yeast,in
R325 T747 T746 cc and,yeast
R326 T748 T746 conj mammals,yeast
R327 T749 T723 punct .,coupled
R328 T751 T752 mark While,is
R329 T752 T763 advcl is,known
R330 T753 T754 poss our,knowledge
R331 T754 T752 nsubj knowledge,is
R332 T755 T754 prep of,knowledge
R333 T756 T757 det the,assembly
R334 T757 T755 pobj assembly,of
R335 T758 T757 cc and,assembly
R336 T759 T757 conj nature,assembly
R337 T760 T757 prep of,assembly
R338 T761 T762 compound recombination,machinery
R339 T762 T760 pobj machinery,of
R340 T764 T752 acomp extensive,is
R341 T765 T763 punct ", ",known
R342 T766 T763 nsubjpass little,known
R343 T767 T763 auxpass is,known
R344 T768 T763 prep about,known
R345 T769 T770 det the,disassembly
R346 T770 T768 pobj disassembly,about
R347 T771 T770 prep of,disassembly
R348 T772 T773 compound recombination,intermediates
R349 T773 T771 pobj intermediates,of
R350 T774 T770 punct ", ",disassembly
R351 T775 T770 conj recruitment,disassembly
R352 T776 T775 prep of,recruitment
R353 T777 T778 compound DNA,machinery
R354 T778 T776 pobj machinery,of
R355 T779 T778 compound replication,machinery
R356 T780 T775 prep during,recruitment
R357 T781 T782 amod recombinational,repair
R358 T782 T780 pobj repair,during
R359 T783 T775 punct ", ",recruitment
R360 T784 T775 cc and,recruitment
R361 T785 T786 advmod how,made
R362 T786 T775 conj made,recruitment
R363 T787 T788 det the,choice
R364 T788 T786 nsubjpass choice,made
R365 T789 T788 prep between,choice
R366 T790 T791 amod different,pathways
R367 T791 T789 pobj pathways,between
R368 T792 T791 compound repair,pathways
R369 T793 T786 auxpass is,made
R370 T794 T763 punct .,known
R371 T796 T797 nsubj Defects,preclude
R372 T798 T796 prep in,Defects
R373 T799 T798 pobj recombination,in
R374 T800 T797 aux can,preclude
R375 T801 T802 amod homologous,pairing
R376 T802 T797 dobj pairing,preclude
R377 T803 T802 compound chromosome,pairing
R378 T804 T797 punct ", ",preclude
R379 T805 T797 conj leave,preclude
R380 T806 T807 amod unrepaired,breaks
R381 T807 T805 dobj breaks,leave
R382 T808 T807 compound chromosome,breaks
R383 T809 T805 punct ", ",leave
R384 T810 T805 cc and,leave
R385 T811 T805 conj cause,leave
R386 T812 T811 dobj aneuploidy,cause
R387 T813 T811 prep by,cause
R388 T814 T813 pcomp abrogating,by
R389 T815 T814 xcomp crossing,abrogating
R390 T816 T815 prt over,crossing
R391 T817 T797 punct .,preclude
R392 T819 T820 aux To,avoid
R393 T820 T821 advcl avoid,exist
R394 T822 T823 amod such,outcomes
R395 T823 T820 dobj outcomes,avoid
R396 T824 T823 amod deleterious,outcomes
R397 T825 T821 punct ", ",exist
R398 T826 T827 compound surveillance,systems
R399 T827 T821 nsubj systems,exist
R400 T828 T827 punct (,systems
R401 T829 T827 punct “,systems
R402 T830 T827 appos checkpoints,systems
R403 T831 T821 punct ”,exist
R404 T832 T821 punct ),exist
R405 T833 T834 aux to,sense
R406 T834 T821 advcl sense,exist
R407 T835 T836 amod meiotic,errors
R408 T836 T834 dobj errors,sense
R409 T837 T834 cc and,sense
R410 T838 T834 conj eliminate,sense
R411 T839 T838 dobj cells,eliminate
R412 T840 T839 acl containing,cells
R413 T841 T842 amod unresolved,defects
R414 T842 T840 dobj defects,containing
R415 T843 T821 punct .,exist
R416 T845 T846 prep In,trigger
R417 T847 T848 amod many,organisms
R418 T848 T845 pobj organisms,In
R419 T849 T848 punct ", ",organisms
R420 T850 T848 prep including,organisms
R421 T851 T852 compound S.,cerevisiae
R422 T852 T850 pobj cerevisiae,including
R423 T853 T852 punct ", ",cerevisiae
R424 T854 T855 compound Drosophila,melanogaster
R425 T855 T852 conj melanogaster,cerevisiae
R426 T856 T855 punct ", ",melanogaster
R427 T857 T858 compound C.,elegans
R428 T858 T855 conj elegans,melanogaster
R429 T859 T858 punct ", ",elegans
R430 T860 T858 cc and,elegans
R431 T861 T858 conj mice,elegans
R432 T862 T863 punct [,1
R433 T863 T861 parataxis 1,mice
R434 T864 T865 punct –,4
R435 T865 T863 prep 4,1
R436 T866 T863 punct ],1
R437 T867 T846 punct ", ",trigger
R438 T868 T846 nsubj meiocytes,trigger
R439 T869 T868 prep with,meiocytes
R440 T870 T869 pobj defects,with
R441 T871 T870 prep in,defects
R442 T872 T871 pobj recombination,in
R443 T873 T872 cc and,recombination
R444 T874 T873 punct /,and
R445 T875 T873 cc or,and
R446 T876 T877 compound chromosome,synapsis
R447 T877 T872 conj synapsis,recombination
R448 T878 T879 amod meiotic,arrest
R449 T879 T846 dobj arrest,trigger
R450 T880 T846 prep in,trigger
R451 T881 T882 det the,stage
R452 T882 T880 pobj stage,in
R453 T883 T882 compound pachytene,stage
R454 T884 T882 prep of,stage
R455 T885 T886 amod meiotic,prophase
R456 T886 T884 pobj prophase,of
R457 T887 T886 nummod I,prophase
R458 T888 T846 punct .,trigger
R459 T890 T891 det This,response
R460 T891 T892 nsubjpass response,referred
R461 T893 T891 prep to,response
R462 T894 T895 amod meiotic,defects
R463 T895 T893 pobj defects,to
R464 T896 T892 auxpass is,referred
R465 T897 T892 prep to,referred
R466 T898 T892 prep as,referred
R467 T899 T900 det the,checkpoint
R468 T900 T898 pobj checkpoint,as
R469 T901 T900 punct “,checkpoint
R470 T902 T900 compound pachytene,checkpoint
R471 T903 T892 dep ”,referred
R472 T904 T905 punct (,reviewed
R473 T905 T892 parataxis reviewed,referred
R474 T906 T905 prep in,reviewed
R475 T907 T908 punct [,5
R476 T908 T906 pobj 5,in
R477 T909 T908 punct ],5
R478 T910 T905 punct ),reviewed
R479 T911 T892 punct .,referred
R480 T913 T914 amod Genetic,experiments
R481 T914 T915 nsubj experiments,identified
R482 T916 T914 prep in,experiments
R483 T917 T918 compound S.,cerevisiae
R484 T918 T916 pobj cerevisiae,in
R485 T919 T915 aux have,identified
R486 T920 T915 dobj elements,identified
R487 T921 T920 prep of,elements
R488 T922 T923 det the,machinery
R489 T923 T921 pobj machinery,of
R490 T924 T923 compound pachytene,machinery
R491 T925 T923 compound checkpoint,machinery
R492 T926 T927 punct (,reviewed
R493 T927 T915 parataxis reviewed,identified
R494 T928 T927 prep in,reviewed
R495 T929 T930 punct [,5
R496 T930 T928 pobj 5,in
R497 T931 T930 punct ],5
R498 T932 T927 punct ),reviewed
R499 T933 T915 punct .,identified
R500 T935 T936 prep In,include
R501 T937 T935 pobj addition,In
R502 T938 T937 prep to,addition
R503 T939 T940 npadvmod meiosis,specific
R504 T940 T942 amod specific,proteins
R505 T941 T940 punct -,specific
R506 T942 T938 pobj proteins,to
R507 T943 T936 punct ", ",include
R508 T944 T936 nsubj these,include
R509 T945 T936 dobj factors,include
R510 T946 T947 dep that,play
R511 T947 T945 relcl play,factors
R512 T948 T947 dobj roles,play
R513 T949 T947 prep in,play
R514 T950 T951 compound DNA,damage
R515 T951 T952 compound damage,signaling
R516 T952 T949 pobj signaling,in
R517 T953 T952 prep in,signaling
R518 T954 T955 amod mitotic,cells
R519 T955 T953 pobj cells,in
R520 T956 T957 punct [,6
R521 T957 T936 parataxis 6,include
R522 T958 T959 punct –,10
R523 T959 T957 prep 10,6
R524 T960 T957 punct ],6
R525 T961 T936 punct .,include
R526 T963 T964 compound Arabidopsis,thaliana
R527 T964 T965 nsubj thaliana,appear
R528 T966 T965 aux does,appear
R529 T967 T965 neg not,appear
R530 T968 T969 aux to,have
R531 T969 T965 xcomp have,appear
R532 T970 T971 det a,checkpoint
R533 T971 T969 dobj checkpoint,have
R534 T972 T971 compound pachytene,checkpoint
R535 T973 T971 amod akin,checkpoint
R536 T974 T973 prep to,akin
R537 T975 T974 pobj that,to
R538 T976 T975 prep in,that
R539 T977 T976 pobj yeast,in
R540 T978 T979 punct [,11
R541 T979 T969 parataxis 11,have
R542 T980 T979 punct ],11
R543 T981 T965 punct ", ",appear
R544 T982 T965 cc nor,appear
R545 T983 T965 conj do,appear
R546 T984 T985 amod male,Drosophila
R547 T985 T983 nsubj Drosophila,do
R548 T986 T983 punct .,do
R549 T988 T989 det The,checkpoint
R550 T989 T991 nsubjpass checkpoint,known
R551 T990 T989 compound pachytene,checkpoint
R552 T992 T991 auxpass is,known
R553 T993 T994 aux to,monitor
R554 T994 T991 xcomp monitor,known
R555 T995 T996 nummod two,aspects
R556 T996 T994 dobj aspects,monitor
R557 T997 T996 prep of,aspects
R558 T998 T999 amod meiotic,metabolism
R559 T999 T997 pobj metabolism,of
R560 T1000 T999 compound chromosome,metabolism
R561 T1001 T999 prep in,metabolism
R562 T1002 T1003 compound S.,cerevisiae
R563 T1003 T1001 pobj cerevisiae,in
R564 T1004 T1003 cc and,cerevisiae
R565 T1005 T1006 compound C.,elegans
R566 T1006 T1003 conj elegans,cerevisiae
R567 T1007 T996 punct : ,aspects
R568 T1008 T1009 punct (,1
R569 T1009 T1010 meta 1,repair
R570 T1010 T996 appos repair,aspects
R571 T1011 T1009 punct ),1
R572 T1012 T1010 compound DSB,repair
R573 T1013 T1010 cc and,repair
R574 T1014 T1015 punct (,2
R575 T1015 T1016 meta 2,synapsis
R576 T1016 T1010 conj synapsis,repair
R577 T1017 T1015 punct ),2
R578 T1018 T1016 compound chromosome,synapsis
R579 T1019 T1020 punct [,12
R580 T1020 T991 parataxis 12,known
R581 T1021 T1020 nummod 2,12
R582 T1022 T1020 punct ",",12
R583 T1023 T1020 punct ],12
R584 T1024 T991 punct .,known
R585 T1026 T1027 prep In,eliminated
R586 T1028 T1026 pobj mice,In
R587 T1029 T1027 punct ", ",eliminated
R588 T1030 T1031 preconj both,spermatocytes
R589 T1031 T1027 nsubjpass spermatocytes,eliminated
R590 T1032 T1031 cc and,spermatocytes
R591 T1033 T1031 conj oocytes,spermatocytes
R592 T1034 T1031 acl harboring,spermatocytes
R593 T1035 T1034 dobj mutations,harboring
R594 T1036 T1037 dep that,disrupt
R595 T1037 T1035 relcl disrupt,mutations
R596 T1038 T1039 compound DSB,repair
R597 T1039 T1037 dobj repair,disrupt
R598 T1040 T1035 punct (,mutations
R599 T1041 T1042 amod such,as
R600 T1042 T1035 prep as,mutations
R601 T1043 T1042 pobj Dmc1,as
R602 T1044 T1043 punct ", ",Dmc1
R603 T1045 T1043 conj Msh5,Dmc1
R604 T1046 T1045 punct ", ",Msh5
R605 T1047 T1045 cc and,Msh5
R606 T1048 T1045 conj Atm,Msh5
R607 T1049 T1027 punct ),eliminated
R608 T1050 T1027 auxpass are,eliminated
R609 T1051 T1027 advmod efficiently,eliminated
R610 T1052 T1027 prep in,eliminated
R611 T1053 T1052 pobj pachynema,in
R612 T1054 T1027 punct ", ",eliminated
R613 T1055 T1027 cc but,eliminated
R614 T1056 T1057 nsubj spermatocytes,are
R615 T1057 T1027 conj are,eliminated
R616 T1058 T1059 advmod much,more
R617 T1059 T1060 advmod more,sensitive
R618 T1060 T1057 acomp sensitive,are
R619 T1061 T1060 prep to,sensitive
R620 T1062 T1063 nmod DSB,defects
R621 T1063 T1061 pobj defects,to
R622 T1064 T1065 npadvmod repair,independent
R623 T1065 T1067 amod independent,synapsis
R624 T1066 T1065 punct –,independent
R625 T1067 T1063 compound synapsis,defects
R626 T1068 T1060 prep than,sensitive
R627 T1069 T1068 pobj oocytes,than
R628 T1070 T1071 punct [,13
R629 T1071 T1027 parataxis 13,eliminated
R630 T1072 T1073 punct –,15
R631 T1073 T1071 prep 15,13
R632 T1074 T1071 punct ],13
R633 T1075 T1027 punct .,eliminated
R634 T1077 T1078 advmod However,remained
R635 T1079 T1078 punct ", ",remained
R636 T1080 T1081 mark because,required
R637 T1081 T1078 advcl required,remained
R638 T1082 T1081 nsubjpass recombination,required
R639 T1083 T1081 auxpass is,required
R640 T1084 T1081 prep for,required
R641 T1085 T1084 pobj synapsis,for
R642 T1086 T1085 prep in,synapsis
R643 T1087 T1086 pobj mice,in
R644 T1088 T1089 punct (,cause
R645 T1089 T1081 parataxis cause,required
R646 T1090 T1089 nsubj mutations,cause
R647 T1091 T1090 prep in,mutations
R648 T1092 T1093 compound recombination,genes
R649 T1093 T1091 pobj genes,in
R650 T1094 T1095 amod such,as
R651 T1095 T1093 prep as,genes
R652 T1096 T1095 pobj Dmc1,as
R653 T1097 T1098 amod extensive,asynapsis
R654 T1098 T1089 dobj asynapsis,cause
R655 T1099 T1100 punct [,16
R656 T1100 T1089 parataxis 16,cause
R657 T1101 T1100 punct ],16
R658 T1102 T1089 punct ),cause
R659 T1103 T1078 punct ", ",remained
R660 T1104 T1078 nsubj it,remained
R661 T1105 T1078 aux has,remained
R662 T1106 T1107 advmod formally,uncertain
R663 T1107 T1078 acomp uncertain,remained
R664 T1108 T1109 mark whether,is
R665 T1109 T1078 advcl is,remained
R666 T1110 T1109 expl there,is
R667 T1111 T1112 det a,checkpoint
R668 T1112 T1109 attr checkpoint,is
R669 T1113 T1112 amod distinct,checkpoint
R670 T1114 T1112 compound pachytene,checkpoint
R671 T1115 T1116 dep that,responds
R672 T1116 T1112 relcl responds,checkpoint
R673 T1117 T1116 prep to,responds
R674 T1118 T1117 pobj defects,to
R675 T1119 T1118 prep in,defects
R676 T1120 T1121 amod meiotic,recombination
R677 T1121 T1119 pobj recombination,in
R678 T1122 T1109 punct ", ",is
R679 T1123 T1109 cc and,is
R713 T1159 T1153 ccomp abolish,identified
R714 T1160 T1159 dobj it,abolish
R715 T1161 T1142 punct .,remain
R716 T1163 T1164 nsubjpass PCH2,determined
R717 T1165 T1163 punct ", ",PCH2
R718 T1166 T1163 acl encoding,PCH2
R719 T1167 T1168 det a,ATPase
R720 T1168 T1166 dobj ATPase,encoding
R721 T1169 T1170 amod nucleolar,localized
R722 T1170 T1168 amod localized,ATPase
R723 T1171 T1170 punct -,localized
R724 T1172 T1168 compound AAA,ATPase
R725 T1173 T1168 punct -,ATPase
R726 T1174 T1175 dep that,identified
R727 T1175 T1166 ccomp identified,encoding
R728 T1176 T1175 auxpass was,identified
R729 T1177 T1175 advmod originally,identified
R730 T1178 T1175 prep in,identified
R731 T1179 T1180 det an,screen
R732 T1180 T1178 pobj screen,in
R733 T1181 T1182 nmod S.,cerevisiae
R734 T1182 T1180 nmod cerevisiae,screen
R735 T1183 T1180 amod genetic,screen
R736 T1184 T1175 prep for,identified
R737 T1185 T1184 pobj mutants,for
R738 T1186 T1187 dep that,relieve
R739 T1187 T1185 relcl relieve,mutants
R740 T1188 T1189 compound pachytene,arrest
R741 T1189 T1187 dobj arrest,relieve
R742 T1190 T1189 prep of,arrest
R743 T1191 T1192 amod asynaptic,mutants
R744 T1192 T1190 pobj mutants,of
R745 T1193 T1192 compound zip1,mutants
R746 T1194 T1195 punct [,8
R747 T1195 T1175 parataxis 8,identified
R748 T1196 T1195 punct ],8
R749 T1197 T1164 punct ", ",determined
R750 T1198 T1164 auxpass was,determined
R751 T1199 T1164 advmod recently,determined
R752 T1200 T1201 aux to,be
R753 T1201 T1164 xcomp be,determined
R754 T1202 T1203 det an,component
R755 T1203 T1201 attr component,be
R756 T1204 T1203 amod essential,component
R757 T1205 T1203 prep of,component
R758 T1206 T1207 det the,checkpoint
R759 T1207 T1205 pobj checkpoint,of
R760 T1208 T1209 nmod pachytene,synapsis
R761 T1209 T1207 nmod synapsis,checkpoint
R762 T1210 T1209 punct (,synapsis
R763 T1211 T1209 cc but,synapsis
R764 T1212 T1211 neg not,but
R765 T1213 T1214 compound DSB,repair
R766 T1214 T1209 conj repair,synapsis
R767 T1215 T1207 punct ),checkpoint
R768 T1216 T1207 prep in,checkpoint
R769 T1217 T1216 pobj yeast,in
R770 T1218 T1217 cc and,yeast
R771 T1219 T1217 conj worms,yeast
R772 T1220 T1221 punct [,12
R773 T1221 T1164 parataxis 12,determined
R774 T1222 T1221 nummod 2,12
R775 T1223 T1221 punct ",",12
R776 T1224 T1221 punct ],12
R777 T1225 T1164 punct .,determined
R778 T1227 T1228 compound PCH2,orthologs
R779 T1228 T1229 nsubj orthologs,are
R780 T1230 T1229 acomp present,are
R781 T1231 T1229 prep in,are
R782 T1232 T1231 pobj organisms,in
R783 T1233 T1234 dep that,undergo
R784 T1234 T1232 relcl undergo,organisms
R785 T1235 T1236 amod synaptic,meiosis
R786 T1236 T1234 dobj meiosis,undergo
R787 T1237 T1236 punct ", ",meiosis
R788 T1238 T1236 cc but,meiosis
R789 T1239 T1238 neg not,but
R790 T1240 T1241 amod asynaptic,meiosis
R802 T1252 T1251 punct -,dependent
R803 T1253 T1254 aux to,monitor
R804 T1254 T1247 advcl monitor,evolved
R805 T1255 T1256 amod synaptonemal,complex
R806 T1256 T1257 nmod complex,defects
R807 T1257 T1254 dobj defects,monitor
R808 T1258 T1256 punct (,complex
R809 T1259 T1256 appos SC,complex
R810 T1260 T1257 punct ),defects
R811 T1261 T1257 prep from,defects
R812 T1262 T1261 pobj yeast,from
R813 T1263 T1257 prep to,defects
R814 T1264 T1263 pobj humans,to
R815 T1265 T1266 punct [,12
R816 T1266 T1229 parataxis 12,are
R817 T1267 T1266 punct ],12
R818 T1268 T1229 punct .,are
R822 T1274 T1271 dobj mice,generated
R823 T1275 T1274 amod deficient,mice
R824 T1276 T1275 prep for,deficient
R825 T1277 T1278 det the,Trip13
R826 T1278 T1276 pobj Trip13,for
R827 T1279 T1278 punct ", ",Trip13
R828 T1280 T1281 det the,ortholog
R829 T1281 T1278 appos ortholog,Trip13
R830 T1282 T1281 prep of,ortholog
R831 T1283 T1282 pobj PCH2,of
R832 T1284 T1271 punct ", ",generated
R833 T1285 T1271 cc and,generated
R834 T1286 T1271 conj evaluated,generated
R835 T1287 T1288 mark whether,plays
R836 T1288 T1286 ccomp plays,evaluated
R837 T1289 T1288 nsubj it,plays
R838 T1290 T1288 advmod also,plays
R839 T1291 T1292 det a,role
R840 T1292 T1288 dobj role,plays
R841 T1293 T1288 prep in,plays
R842 T1294 T1295 det the,checkpoint
R843 T1295 T1293 pobj checkpoint,in
R844 T1296 T1295 compound pachytene,checkpoint
R845 T1297 T1271 punct .,generated
R846 T1299 T1300 advmod Surprisingly,uncover
R847 T1301 T1300 punct ", ",uncover
R848 T1302 T1303 mark while,found
R850 T1304 T1303 nsubj we,found
R851 T1305 T1306 det no,evidence
R852 T1306 T1303 dobj evidence,found
R853 T1307 T1303 prep for,found
R854 T1308 T1309 compound checkpoint,function
R855 T1309 T1307 pobj function,for
R856 T1310 T1300 punct ", ",uncover
R857 T1311 T1300 nsubj we,uncover
R858 T1312 T1300 aux did,uncover
R859 T1313 T1314 det a,role
R860 T1314 T1300 dobj role,uncover
R861 T1315 T1314 amod potential,role
R862 T1316 T1314 prep for,role
R863 T1317 T1318 det this,protein
R864 T1318 T1316 pobj protein,for
R865 T1319 T1314 prep in,role
R866 T1320 T1321 amod noncrossover,NCO
R867 T1321 T1323 amod NCO,repair
R868 T1322 T1321 punct (,NCO
R869 T1323 T1319 pobj repair,in
R870 T1324 T1323 punct ),repair
R871 T1325 T1323 prep of,repair
R872 T1326 T1327 amod meiotic,DSBs
R873 T1327 T1325 pobj DSBs,of
R874 T1328 T1300 punct .,uncover
R879 T1407 T1408 nsubj Trip13,Is
R880 T1409 T1410 det a,Ortholog
R881 T1410 T1408 attr Ortholog,Is
R882 T1411 T1412 advmod Widely,Expressed
R883 T1412 T1410 amod Expressed,Ortholog
R884 T1413 T1410 amod Mammalian,Ortholog
R885 T1414 T1410 prep of,Ortholog
R886 T1415 T1414 pobj PCH2,of
R887 T1416 T1410 prep with,Ortholog
R888 T1417 T1418 amod Unusual,Relationships
R889 T1418 T1416 pobj Relationships,with
R890 T1419 T1418 amod Phylogenetic,Relationships
R891 T1421 T1422 det The,ortholog
R892 T1422 T1424 nsubj ortholog,encodes
R893 T1423 T1422 amod mammalian,ortholog
R894 T1425 T1422 prep of,ortholog
R895 T1426 T1425 pobj PCH2,of
R896 T1427 T1422 punct ", ",ortholog
R897 T1428 T1422 appos Trip13,ortholog
R898 T1429 T1428 punct (,Trip13
R899 T1430 T1431 compound thyroid,receptor
R900 T1431 T1433 npadvmod receptor,interacting
R901 T1432 T1431 compound hormone,receptor
R902 T1433 T1434 amod interacting,protein
R903 T1434 T1428 appos protein,Trip13
R904 T1435 T1434 nummod 13,protein
R905 T1436 T1424 punct ),encodes
R906 T1437 T1424 punct ", ",encodes
R907 T1438 T1439 det a,protein
R908 T1439 T1424 dobj protein,encodes
R909 T1440 T1439 prep with,protein
R910 T1441 T1442 amod extensive,homology
R911 T1442 T1440 pobj homology,with
R912 T1443 T1444 compound amino,acid
R913 T1444 T1442 compound acid,homology
R914 T1445 T1442 prep in,homology
R915 T1446 T1445 pobj regions,in
R916 T1447 T1446 amod alignable,regions
R917 T1448 T1447 prep to,alignable
R918 T1449 T1450 det the,orthologs
R919 T1450 T1448 pobj orthologs,to
R920 T1451 T1450 nmod yeast,orthologs
R926 T1457 T1455 punct ),S1
R927 T1458 T1459 punct [,12
R928 T1459 T1424 parataxis 12,encodes
R929 T1460 T1459 punct ],12
R930 T1461 T1424 punct ),encodes
R931 T1462 T1424 punct .,encodes
R932 T1464 T1465 advmod Interestingly,shows
R933 T1466 T1465 punct ", ",shows
R934 T1467 T1468 amod phylogenetic,analysis
R935 T1468 T1465 nsubj analysis,shows
R936 T1469 T1468 prep of,analysis
R937 T1470 T1471 compound TRIP13,Pch2p
R938 T1471 T1469 pobj Pch2p,of
R939 T1472 T1471 punct /,Pch2p
R940 T1473 T1474 mark that,clusters
R941 T1474 T1465 ccomp clusters,shows
R942 T1475 T1476 det the,protein
R943 T1476 T1474 nsubj protein,clusters
R944 T1477 T1476 amod mammalian,protein
R945 T1478 T1479 advmod more,closely
R946 T1479 T1474 advmod closely,clusters
R947 T1480 T1474 prep to,clusters
R948 T1481 T1480 pobj plants,to
R949 T1482 T1483 mark than,to
R950 T1483 T1474 advcl to,clusters
R951 T1484 T1483 nsubj it,to
R952 T1485 T1483 aux does,to
R953 T1486 T1487 det the,worms
R954 T1487 T1483 pobj worms,to
R955 T1488 T1489 advmod evolutionarily,related
R956 T1489 T1487 amod related,worms
R957 T1490 T1491 advmod more,closely
R958 T1491 T1489 advmod closely,related
R959 T1492 T1487 cc and,worms
R960 T1493 T1487 conj flies,worms
R961 T1494 T1495 punct (,1A
R962 T1495 T1465 parataxis 1A,shows
R963 T1496 T1495 compound Figure,1A
R964 T1497 T1495 punct ;,1A
R965 T1498 T1495 advcl see,1A
R966 T1499 T1498 dobj Discussion,see
R967 T1500 T1495 punct ),1A
R968 T1501 T1465 punct .,shows
R969 T1503 T1504 amod Semi-quantitative,analysis
R970 T1504 T1514 nsubj analysis,showed
R971 T1505 T1506 nmod reverse,transcriptase
R972 T1506 T1508 nmod transcriptase,PCR
R973 T1507 T1506 punct -,transcriptase
R974 T1508 T1504 nmod PCR,analysis
R975 T1509 T1508 punct (,PCR
R976 T1510 T1511 compound RT,PCR
R977 T1511 T1508 appos PCR,PCR
R978 T1512 T1511 punct -,PCR
R979 T1513 T1504 punct ),analysis
R980 T1515 T1516 compound Trip13,mRNA
R981 T1516 T1517 nsubjpass mRNA,expressed
R982 T1517 T1514 ccomp expressed,showed
R983 T1518 T1517 aux to,expressed
R984 T1519 T1517 auxpass be,expressed
R985 T1520 T1517 prep in,expressed
R986 T1521 T1522 det a,variety
R987 T1522 T1520 pobj variety,in
R988 T1523 T1522 prep of,variety
R989 T1524 T1525 amod embryonic,tissues
R990 T1525 T1523 pobj tissues,of
R991 T1526 T1524 cc and,embryonic
R992 T1527 T1524 conj adult,embryonic
R993 T1528 T1525 punct ", ",tissues
R994 T1529 T1525 prep including,tissues
R995 T1530 T1529 pobj testis,including
R996 T1531 T1532 punct (,1B
R997 T1532 T1530 parataxis 1B,testis
R998 T1533 T1532 compound Figure,1B
R999 T1534 T1532 punct ),1B
R1000 T1535 T1517 punct ", ",expressed
R1001 T1536 T1517 advcl consistent,expressed
R1002 T1537 T1536 prep with,consistent
R1003 T1538 T1539 nmod mouse,EST
R1004 T1539 T1542 compound EST,data
R1005 T1540 T1538 cc and,mouse
R1006 T1541 T1538 conj human,mouse
R1007 T1542 T1537 pobj data,with
R1008 T1543 T1542 acl summarized,data
R1009 T1544 T1543 prep in,summarized
R1010 T1545 T1544 pobj Unigene,in
R1011 T1546 T1547 punct (,http://www.ncbi.nlm.nih.gov/UniGene
R1012 T1547 T1545 parataxis http://www.ncbi.nlm.nih.gov/UniGene,Unigene
R1013 T1548 T1547 punct ),http://www.ncbi.nlm.nih.gov/UniGene
R1014 T1549 T1514 punct .,showed
R1015 T1551 T1552 nsubjpass It,expressed
R1016 T1553 T1552 auxpass is,expressed
R1017 T1554 T1552 advmod also,expressed
R1018 T1555 T1552 advmod highly,expressed
R1019 T1556 T1552 prep in,expressed
R1020 T1557 T1558 amod human,mouse
R1021 T1558 T1560 compound mouse,oocytes
R1022 T1559 T1558 cc and,mouse
R1023 T1560 T1556 pobj oocytes,in
R1024 T1561 T1562 punct [,17
R1025 T1562 T1552 parataxis 17,expressed
R1026 T1563 T1562 punct ],17
R1027 T1564 T1552 punct .,expressed
R1028 T1726 T1725 prep of,Generation
R1029 T1727 T1728 compound Trip13,Mice
R1030 T1728 T1726 pobj Mice,of
R1031 T1729 T1728 compound Mutant,Mice
R1032 T1731 T1732 aux To,explore
R1033 T1732 T1733 advcl explore,generated
R1034 T1734 T1735 det the,function
R1035 T1735 T1732 dobj function,explore
R1036 T1736 T1735 prep of,function
R1037 T1737 T1736 pobj TRIP13,of
R1038 T1738 T1735 prep in,function
R1039 T1739 T1738 pobj mammals,in
R1040 T1740 T1733 punct ", ",generated
R1041 T1741 T1733 nsubj we,generated
R1042 T1742 T1733 dobj mice,generated
R1043 T1743 T1742 prep with,mice
R1044 T1744 T1745 det a,allele
R1045 T1745 T1743 pobj allele,with
R1046 T1746 T1747 compound gene,trap
R1047 T1747 T1748 npadvmod trap,disrupted
R1048 T1748 T1745 amod disrupted,allele
R1049 T1749 T1748 punct -,disrupted
R1050 T1750 T1745 punct ", ",allele
R1051 T1751 T1745 appos Trip13RRB047,allele
R1052 T1752 T1753 punct (,1C
R1053 T1753 T1733 parataxis 1C,generated
R1054 T1754 T1753 compound Figure,1C
R1055 T1755 T1753 punct ;,1C
R1056 T1756 T1753 advcl abbreviated,1C
R1057 T1757 T1756 prep as,abbreviated
R1058 T1758 T1757 pobj Trip13Gt,as
R1059 T1759 T1753 punct ),1C
R1060 T1760 T1733 punct .,generated
R1061 T1762 T1763 nsubj Heterozygotes,were
R1062 T1764 T1763 acomp normal,were
R1063 T1765 T1763 prep in,were
R1064 T1766 T1767 det all,respects
R1065 T1767 T1765 pobj respects,in
R1066 T1768 T1763 punct ", ",were
R1067 T1769 T1763 cc but,were
R1068 T1770 T1771 nsubj homozygotes,were
R1069 T1771 T1763 conj were,were
R1070 T1772 T1771 acomp present,were
R1071 T1773 T1771 prep at,were
R1072 T1774 T1775 punct ∼,3
R1073 T1775 T1778 nummod 3,ratio
R1074 T1776 T1775 quantmod 2,3
R1075 T1777 T1775 punct /,3
R1076 T1778 T1773 pobj ratio,at
R1077 T1779 T1778 det the,ratio
R1078 T1780 T1778 amod expected,ratio
R1079 T1781 T1778 prep from,ratio
R1080 T1782 T1781 pobj intercrosses,from
R1081 T1783 T1782 prep between,intercrosses
R1082 T1784 T1783 pobj heterozygotes,between
R1083 T1785 T1782 punct (,intercrosses
R1084 T1786 T1787 nummod 91,Trip13
R1085 T1787 T1782 appos Trip13,intercrosses
R1086 T1788 T1787 punct +,Trip13
R1087 T1789 T1787 punct /,Trip13
R1088 T1790 T1787 punct +,Trip13
R1089 T1791 T1787 punct ", ",Trip13
R1090 T1792 T1793 nummod 183,Trip13Gt
R1091 T1793 T1787 conj Trip13Gt,Trip13
R1092 T1794 T1793 punct /,Trip13Gt
R1093 T1795 T1793 punct +,Trip13Gt
R1094 T1796 T1793 punct ", ",Trip13Gt
R1095 T1797 T1793 cc and,Trip13Gt
R1096 T1798 T1799 nummod 61,Gt
R1097 T1799 T1793 conj Gt,Trip13Gt
R1098 T1800 T1799 compound Trip13Gt,Gt
R1099 T1801 T1799 punct /,Gt
R1100 T1802 T1771 punct ),were
R1101 T1803 T1771 punct .,were
R1102 T1805 T1806 mark Since,were
R1103 T1806 T1815 advcl were,is
R1104 T1807 T1808 punct >,90
R1105 T1808 T1809 nummod 90,%
R1106 T1809 T1806 nsubj %,were
R1107 T1810 T1809 prep of,%
R1108 T1811 T1812 amod prewean,mice
R1109 T1812 T1810 pobj mice,of
R1110 T1813 T1814 dep that,died
R1111 T1814 T1812 relcl died,mice
R1112 T1816 T1817 compound mutant,homozygotes
R1113 T1817 T1806 attr homozygotes,were
R1114 T1818 T1815 punct ", ",is
R1115 T1819 T1820 det this,discrepancy
R1116 T1820 T1815 nsubj discrepancy,is
R1117 T1821 T1815 advmod apparently,is
R1118 T1822 T1815 prep due,is
R1119 T1823 T1822 pcomp to,due
R1120 T1824 T1825 det a,lethality
R1121 T1825 T1822 pobj lethality,due
R1122 T1826 T1827 advmod partially,penetrant
R1123 T1827 T1825 amod penetrant,lethality
R1124 T1828 T1815 punct .,is
R1125 T1830 T1831 amod Most,animals
R1126 T1831 T1836 nsubj animals,were
R1127 T1832 T1831 amod surviving,animals
R1128 T1833 T1834 compound Trip13Gt,Gt
R1129 T1834 T1831 compound Gt,animals
R1130 T1835 T1834 punct /,Gt
R1131 T1837 T1838 advmod grossly,normal
R1132 T1838 T1836 acomp normal,were
R1133 T1839 T1836 punct .,were
R1134 T1841 T1842 advmod However,were
R1135 T1843 T1842 punct ", ",were
R1136 T1844 T1842 nsubj homozygotes,were
R1137 T1845 T1846 dep that,were
R1138 T1846 T1844 relcl were,homozygotes
R1139 T1847 T1846 acomp semi-congenic,were
R1195 T1906 T1907 amod incomplete,usage
R1196 T1907 T1905 pobj usage,of
R1197 T1908 T1907 prep of,usage
R1198 T1909 T1910 det the,trap
R1199 T1910 T1912 poss trap,acceptor
R1200 T1911 T1910 compound gene,trap
R1201 T1912 T1908 pobj acceptor,of
R1202 T1913 T1910 case 's,trap
R1203 T1914 T1912 compound splice,acceptor
R1204 T1915 T1881 punct .,revealed
R1205 T1917 T1918 compound Western,blot
R1206 T1918 T1919 compound blot,analysis
R1207 T1919 T1920 nsubj analysis,revealed
R1208 T1921 T1919 punct ", ",analysis
R1209 T1922 T1919 acl using,analysis
R1210 T1923 T1924 det a,antibody
R1211 T1924 T1922 dobj antibody,using
R1212 T1925 T1924 amod polyclonal,antibody
R1213 T1926 T1924 acl raised,antibody
R1214 T1927 T1926 prep against,raised
R1215 T1928 T1929 det a,peptide
R1216 T1929 T1927 pobj peptide,against
R1217 T1930 T1929 acl encoded,peptide
R1218 T1931 T1930 agent by,encoded
R1219 T1932 T1931 pobj exon,by
R1220 T1933 T1932 nummod 3,exon
R1221 T1934 T1920 punct ", ",revealed
R1222 T1935 T1936 amod multiple,species
R1223 T1936 T1920 dobj species,revealed
R1224 T1937 T1936 prep in,species
R1225 T1938 T1939 amod wild,type
R1226 T1939 T1941 nmod type,testes
R1227 T1940 T1939 punct -,type
R1228 T1941 T1937 pobj testes,in
R1229 T1942 T1939 cc and,type
R1230 T1943 T1939 conj heterozygous,type
R1231 T1944 T1936 punct ", ",species
R1232 T1945 T1946 dep one,corresponds
R1233 T1946 T1936 relcl corresponds,species
R1234 T1947 T1945 prep of,one
R1235 T1948 T1947 pobj which,of
R1236 T1949 T1946 prep to,corresponds
R1237 T1950 T1951 det the,size
R1238 T1951 T1949 pobj size,to
R1239 T1952 T1951 amod expected,size
R1240 T1953 T1951 prep of,size
R1241 T1954 T1955 nummod 48,kDa
R1242 T1955 T1953 pobj kDa,of
R1243 T1956 T1957 punct (,1E
R1244 T1957 T1920 parataxis 1E,revealed
R1245 T1958 T1957 compound Figure,1E
R1246 T1959 T1957 punct ),1E
R1247 T1960 T1920 punct .,revealed
R1248 T1962 T1963 nsubj This,were
R1249 T1964 T1962 cc and,This
R1250 T1965 T1966 nummod three,species
R1251 T1966 T1962 conj species,This
R1252 T1967 T1966 amod other,species
R1253 T1968 T1963 acomp undetectable,were
R1254 T1969 T1963 prep in,were
R1255 T1970 T1971 amod homozygous,mutant
R1256 T1971 T1972 compound mutant,testes
R1257 T1972 T1969 pobj testes,in
R1258 T1973 T1963 punct ", ",were
R1259 T1974 T1963 cc but,were
R1260 T1975 T1976 det a,amount
R1261 T1976 T1978 nsubj amount,was
R1262 T1977 T1976 amod reduced,amount
R1263 T1978 T1963 conj was,were
R1264 T1979 T1976 prep of,amount
R1265 T1980 T1981 det an,band
R1266 T1981 T1979 pobj band,of
R1267 T1982 T1981 amod intense,band
R1268 T1983 T1984 punct ∼,38
R1269 T1984 T1985 nummod 38,kDa
R1270 T1985 T1986 npadvmod kDa,smaller
R1271 T1986 T1981 amod smaller,band
R1272 T1987 T1978 acomp present,was
R1273 T1988 T1978 punct .,was
R1274 T1990 T1991 nsubj It,is
R1275 T1992 T1991 neg not,is
R1276 T1993 T1991 acomp clear,is
R1277 T1994 T1995 mark if,corresponds
R1278 T1995 T1991 ccomp corresponds,is
R1279 T1996 T1995 nsubj this,corresponds
R1280 T1997 T1995 prep to,corresponds
R1281 T1998 T1997 pobj TRIP13,to
R1282 T1999 T1991 punct .,is
R1283 T2001 T2002 det The,mRNA
R1284 T2002 T2006 nsubj mRNA,indicate
R1285 T2003 T2004 advmod greatly,decreased
R1286 T2004 T2002 amod decreased,mRNA
R1287 T2005 T2002 compound Trip13,mRNA
R1288 T2007 T2002 cc and,mRNA
R1289 T2008 T2009 amod predicted,protein
R1290 T2009 T2002 conj protein,mRNA
R1291 T2010 T2011 amod correct,length
R1292 T2011 T2009 compound length,protein
R1293 T2012 T2011 punct -,length
R1294 T2013 T2009 prep in,protein
R1295 T2014 T2013 pobj mutants,in
R1296 T2015 T2016 mark that,is
R1297 T2016 T2006 ccomp is,indicate
R1298 T2017 T2018 det the,allele
R1299 T2018 T2016 nsubj allele,is
R1300 T2019 T2018 compound Trip13RRB047,allele
R1301 T2020 T2021 advmod severely,hypomorphic
R1302 T2021 T2016 acomp hypomorphic,is
R1303 T2022 T2006 punct .,indicate
R1304 T2024 T2025 aux To,determine
R1305 T2025 T2026 advcl determine,immunolabeled
R1306 T2027 T2028 det the,types
R1307 T2028 T2025 dobj types,determine
R1308 T2029 T2030 compound germ,cell
R1309 T2030 T2028 compound cell,types
R1310 T2031 T2032 prep in,expressed
R1311 T2032 T2028 relcl expressed,types
R1312 T2033 T2031 pobj which,in
R1313 T2034 T2032 nsubjpass TRIP13,expressed
R1314 T2035 T2032 auxpass is,expressed
R1315 T2036 T2025 punct ", ",determine
R1316 T2037 T2025 cc and,determine
R1317 T2038 T2039 aux to,assess
R1318 T2039 T2025 conj assess,determine
R1319 T2040 T2041 amod possible,expression
R1320 T2041 T2039 dobj expression,assess
R1321 T2042 T2041 prep in,expression
R1322 T2043 T2044 det the,mutant
R1323 T2044 T2042 pobj mutant,in
R1324 T2045 T2039 prep by,assess
R1325 T2046 T2045 pobj means,by
R1326 T2047 T2046 amod other,means
R1327 T2048 T2047 prep than,other
R1328 T2049 T2050 compound Western,analysis
R1329 T2050 T2048 pobj analysis,than
R1330 T2051 T2026 punct ", ",immunolabeled
R1331 T2052 T2053 compound testis,sections
R1332 T2053 T2026 nsubjpass sections,immunolabeled
R1333 T2054 T2026 auxpass were,immunolabeled
R1334 T2055 T2026 prep for,immunolabeled
R1335 T2056 T2055 pobj TRIP13,for
R1336 T2057 T2026 advcl using,immunolabeled
R1337 T2058 T2059 det a,antibody
R1338 T2059 T2057 dobj antibody,using
R1339 T2060 T2061 amod polyclonal,antipeptide
R1340 T2061 T2059 compound antipeptide,antibody
R1341 T2062 T2061 compound chicken,antipeptide
R1342 T2063 T2064 punct (,see
R1343 T2064 T2026 parataxis see,immunolabeled
R1344 T2065 T2064 dobj Materials,see
R1345 T2066 T2065 cc and,Materials
R1346 T2067 T2065 conj Methods,Materials
R1347 T2068 T2064 punct ),see
R1348 T2069 T2026 punct .,immunolabeled
R1349 T2071 T2072 det The,cells
R1350 T2072 T2076 nsubj cells,were
R1351 T2073 T2074 advmod most,intensely
R1352 T2074 T2075 advmod intensely,labeled
R1353 T2075 T2072 amod labeled,cells
R1354 T2077 T2072 prep in,cells
R1355 T2078 T2079 compound control,testes
R1356 T2079 T2077 pobj testes,in
R1357 T2080 T2081 compound Type,B
R1358 T2081 T2082 compound B,spermatogonia
R1359 T2082 T2076 attr spermatogonia,were
R1360 T2083 T2082 cc and,spermatogonia
R1361 T2084 T2085 compound leptotene,spermatocytes
R1362 T2085 T2082 conj spermatocytes,spermatogonia
R1363 T2086 T2087 punct (,1F
R1364 T2087 T2076 parataxis 1F,were
R1365 T2088 T2087 compound Figure,1F
R1366 T2089 T2087 punct ),1F
R1367 T2090 T2076 punct .,were
R1368 T2092 T2093 compound Zygotene,pachytene
R1369 T2093 T2095 compound pachytene,spermatocytes
R1370 T2094 T2093 punct /,pachytene
R1371 T2095 T2096 nsubj spermatocytes,stained
R1372 T2097 T2098 advmod less,strongly
R1373 T2098 T2096 advmod strongly,stained
R1374 T2099 T2096 punct ", ",stained
R1375 T2100 T2096 cc and,stained
R1376 T2101 T2102 expl there,was
R1377 T2102 T2096 conj was,stained
R1378 T2103 T2104 det no,staining
R1379 T2104 T2102 attr staining,was
R1380 T2105 T2104 amod detectable,staining
R1381 T2106 T2104 prep in,staining
R1382 T2107 T2108 amod late,pachytene
R1383 T2108 T2109 compound pachytene,spermatocytes
R1384 T2109 T2106 pobj spermatocytes,in
R1385 T2110 T2102 punct .,was
R1386 T2112 T2113 nsubj TRIP13,appeared
R1387 T2114 T2115 aux to,be
R1388 T2115 T2113 xcomp be,appeared
R1389 T2116 T2117 amod nuclear,localized
R1390 T2117 T2115 acomp localized,be
R1391 T2118 T2113 punct .,appeared
R1392 T2120 T2121 expl There,was
R1393 T2122 T2123 det no,staining
R1394 T2123 T2121 attr staining,was
R1395 T2124 T2123 amod such,staining
R1396 T2125 T2123 prep of,staining
R1397 T2126 T2125 pobj nuclei,of
R1398 T2127 T2121 prep in,was
R1399 T2128 T2129 nmod mutant,tubules
R1400 T2129 T2127 pobj tubules,in
R1401 T2130 T2129 amod seminiferous,tubules
R1402 T2131 T2132 punct (,1F
R1403 T2132 T2121 parataxis 1F,was
R1404 T2133 T2132 compound Figure,1F
R1405 T2134 T2132 punct ),1F
R1406 T2135 T2121 punct .,was
R1407 T2137 T2138 aux To,assess
R1408 T2138 T2140 advcl assess,used
R1409 T2139 T2138 advmod further,assess
R1410 T2141 T2142 det the,localization
R1411 T2142 T2138 dobj localization,assess
R1412 T2143 T2142 amod nuclear,localization
R1413 T2144 T2140 punct ", ",used
R1414 T2145 T2140 nsubjpass TRIP13,used
R1415 T2146 T2140 auxpass was,used
R1416 T2147 T2148 aux to,probe
R1417 T2148 T2140 advcl probe,used
R1418 T2149 T2150 amod meiotic,chromosomes
R1419 T2150 T2148 dobj chromosomes,probe
R1420 T2151 T2150 acl prepared,chromosomes
R1421 T2152 T2151 prep by,prepared
R1422 T2153 T2154 compound surface,spreading
R1423 T2154 T2152 pobj spreading,by
R1424 T2155 T2154 prep of,spreading
R1425 T2156 T2157 compound spermatocyte,nuclei
R1426 T2157 T2155 pobj nuclei,of
R1427 T2158 T2140 punct .,used
R1428 T2160 T2161 prep In,was
R1429 T2162 T2163 amod wild,type
R1430 T2163 T2160 pobj type,In
R1431 T2164 T2161 punct ", ",was
R1432 T2165 T2161 expl there,was
R1433 T2166 T2167 amod diffuse,staining
R1434 T2167 T2161 attr staining,was
R1435 T2168 T2167 amod nuclear,staining
R1436 T2169 T2167 punct ", ",staining
R1437 T2170 T2167 cc and,staining
R1438 T2171 T2172 det no,evidence
R1439 T2172 T2167 conj evidence,staining
R1440 T2173 T2172 prep of,evidence
R1441 T2174 T2173 pobj concentration,of
R1442 T2175 T2174 prep on,concentration
R1443 T2176 T2177 compound SC,cores
R1444 T2177 T2175 pobj cores,on
R1445 T2178 T2174 punct (,concentration
R1446 T2179 T2174 acl marked,concentration
R1447 T2180 T2179 agent by,marked
R1448 T2181 T2182 det the,SYCP3
R1449 T2182 T2180 pobj SYCP3,by
R1450 T2183 T2184 amod axial,element
R1451 T2184 T2185 compound element,protein
R1452 T2185 T2182 compound protein,SYCP3
R1453 T2186 T2172 punct ),evidence
R1454 T2187 T2172 prep at,evidence
R1455 T2188 T2189 det any,substage
R1456 T2189 T2187 pobj substage,at
R1457 T2190 T2189 amod meiotic,substage
R1458 T2191 T2192 punct (,1G
R1459 T2192 T2161 parataxis 1G,was
R1460 T2193 T2192 compound Figure,1G
R1461 T2194 T2192 punct ),1G
R1462 T2195 T2161 punct .,was
R1463 T2197 T2198 compound TRIP13,signal
R1464 T2198 T2199 nsubj signal,was
R1465 T2200 T2201 advmod noticeably,absent
R1466 T2201 T2199 acomp absent,was
R1467 T2202 T2199 prep in,was
R1468 T2203 T2204 nmod mutant,nuclei
R1469 T2204 T2202 pobj nuclei,in
R1470 T2205 T2204 amod meiotic,nuclei
R1471 T2206 T2199 punct .,was
R1474 T2305 T2304 prep Due,Infertility
R1475 T2306 T2305 pcomp to,Due
R1476 T2307 T2308 amod Meiotic,Disruption
R1477 T2308 T2305 pobj Disruption,Due
R1478 T2309 T2304 prep in,Infertility
R1479 T2310 T2311 npadvmod TRIP13,Deficient
R1480 T2311 T2313 amod Deficient,Meiocytes
R1481 T2312 T2311 punct -,Deficient
R1482 T2313 T2309 pobj Meiocytes,in
R1483 T2315 T2316 nsubj Homozygotes,had
R1484 T2317 T2315 prep of,Homozygotes
R1485 T2318 T2319 det both,sexes
R1486 T2319 T2317 pobj sexes,of
R1487 T2320 T2321 amod small,gonads
R1488 T2321 T2316 dobj gonads,had
R1489 T2322 T2323 punct (,2C
R1490 T2323 T2316 parataxis 2C,had
R1491 T2324 T2323 compound Figure,2C
R1492 T2325 T2323 punct ;,2C
R1493 T2326 T2323 advcl see,2C
R1494 T2327 T2326 advmod below,see
R1495 T2328 T2323 punct ),2C
R1496 T2329 T2316 cc and,had
R1497 T2330 T2316 conj were,had
R1498 T2331 T2332 advmod invariably,sterile
R1499 T2332 T2330 acomp sterile,were
R1500 T2333 T2316 punct .,had
R1501 T2335 T2336 nsubj Ovaries,were
R1502 T2337 T2335 prep of,Ovaries
R1503 T2338 T2339 amod adult,females
R1504 T2339 T2337 pobj females,of
R1505 T2340 T2341 compound Trip13Gt,Gt
R1506 T2341 T2339 compound Gt,females
R1507 T2342 T2341 punct /,Gt
R1508 T2343 T2344 advmod severely,dysmorphic
R1509 T2344 T2336 acomp dysmorphic,were
R1510 T2345 T2336 cc and,were
R1511 T2346 T2336 conj had,were
R1512 T2347 T2348 amod few,follicles
R1513 T2348 T2346 dobj follicles,had
R1514 T2349 T2348 cc or,follicles
R1515 T2350 T2348 det no,follicles
R1516 T2351 T2352 punct (,3A
R1517 T2352 T2346 parataxis 3A,had
R1518 T2353 T2352 compound Figure,3A
R1519 T2354 T2352 cc and,3A
R1520 T2355 T2352 conj 3B,3A
R1521 T2356 T2352 punct ),3A
R1522 T2357 T2336 punct .,were
R1523 T2359 T2360 det The,majority
R1524 T2360 T2361 nsubj majority,occurred
R1525 T2362 T2360 prep of,majority
R1526 T2363 T2364 compound oocyte,loss
R1527 T2364 T2362 pobj loss,of
R1528 T2365 T2361 prep in,occurred
R1529 T2366 T2367 amod late,embryogenesis
R1530 T2367 T2365 pobj embryogenesis,in
R1531 T2368 T2365 cc or,in
R1532 T2369 T2370 advmod early,in
R1533 T2370 T2365 conj in,in
R1534 T2371 T2372 amod postnatal,development
R1535 T2372 T2370 pobj development,in
R1536 T2373 T2361 punct ", ",occurred
R1537 T2374 T2375 mark since,were
R1538 T2375 T2361 advcl were,occurred
R1539 T2376 T2377 nummod 2,d
R1540 T2377 T2378 nmod d,ovaries
R1541 T2378 T2375 nsubj ovaries,were
R1542 T2379 T2378 advmod postpartum,ovaries
R1543 T2380 T2381 advmod markedly,smaller
R1544 T2381 T2375 acomp smaller,were
R1545 T2382 T2381 prep than,smaller
R1546 T2383 T2382 pobj those,than
R1547 T2384 T2383 prep of,those
R1548 T2385 T2386 compound control,littermates
R1549 T2386 T2384 pobj littermates,of
R1550 T2387 T2375 punct ", ",were
R1551 T2388 T2375 cc and,were
R1552 T2389 T2390 aux were,lacking
R1553 T2390 T2375 conj lacking,were
R1554 T2391 T2390 dobj oocytes,lacking
R1555 T2392 T2391 cc or,oocytes
R1556 T2393 T2394 advmod newly,forming
R1557 T2394 T2395 amod forming,follicles
R1585 T2426 T2427 compound stage,chromosomes
R1586 T2427 T2424 pobj chromosomes,with
R1587 T2428 T2427 prep in,chromosomes
R1588 T2429 T2430 nummod 17.5,d
R1589 T2430 T2431 nmod d,ovaries
R1590 T2431 T2428 pobj ovaries,in
R1591 T2432 T2433 nmod Trip13Gt,Gt
R1592 T2433 T2431 nmod Gt,ovaries
R1593 T2434 T2433 punct /,Gt
R1594 T2435 T2431 amod embryonic,ovaries
R1595 T2436 T2437 punct (,data
R1596 T2437 T2420 meta data,observed
R1597 T2438 T2437 amod unpublished,data
R1598 T2439 T2437 punct ),data
R1599 T2440 T2422 punct ", ",indicates
R1600 T2441 T2422 nsubj this,indicates
R1601 T2442 T2443 mark that,eliminated
R1602 T2443 T2422 ccomp eliminated,indicates
R1603 T2444 T2443 nsubjpass oocytes,eliminated
R1604 T2445 T2443 auxpass were,eliminated
R1605 T2446 T2443 advmod somewhere,eliminated
R1606 T2447 T2446 prep between,somewhere
R1607 T2448 T2447 pobj pachynema,between
R1608 T2449 T2448 cc and,pachynema
R1609 T2450 T2448 conj dictyate,pachynema
R1610 T2451 T2422 punct .,indicates
R1618 T2461 T2460 prep of,lack
R1619 T2462 T2463 amod postmeiotic,types
R1620 T2463 T2461 pobj types,of
R1621 T2464 T2463 compound cell,types
R1622 T2465 T2466 dep that,are
R1623 T2466 T2463 relcl are,types
R1624 T2467 T2466 acomp characteristic,are
R1625 T2468 T2467 prep of,characteristic
R1626 T2469 T2470 amod wild,type
R1627 T2470 T2472 nmod type,tubules
R1628 T2471 T2470 punct -,type
R1629 T2472 T2468 pobj tubules,of
R1630 T2473 T2472 amod seminiferous,tubules
R1631 T2474 T2475 punct (,3E
R1632 T2475 T2455 parataxis 3E,revealed
R1633 T2476 T2475 compound Figure,3E
R1634 T2477 T2475 punct ),3E
R1635 T2478 T2455 punct .,revealed
R1636 T2480 T2481 det The,tubules
R1637 T2481 T2486 nsubj tubules,contained
R1638 T2482 T2483 advmod most,advanced
R1639 T2483 T2481 amod advanced,tubules
R1640 T2484 T2483 advmod developmentally,advanced
R1641 T2485 T2481 amod seminiferous,tubules
R1642 T2487 T2488 amod adluminal,spermatocytes
R1643 T2488 T2486 dobj spermatocytes,contained
R1644 T2489 T2488 prep with,spermatocytes
R1645 T2490 T2491 amod condensed,chromatin
R1646 T2491 T2489 pobj chromatin,with
R1647 T2492 T2488 amod characteristic,spermatocytes
R1648 T2493 T2492 prep of,characteristic
R1649 T2494 T2493 pobj pachynema,of
R1650 T2495 T2496 punct (,3F
R1651 T2496 T2486 parataxis 3F,contained
R1652 T2497 T2496 compound Figure,3F
R1653 T2498 T2496 punct ),3F
R1654 T2499 T2486 punct .,contained
R1655 T2501 T2502 det The,absence
R1656 T2502 T2503 nsubj absence,is
R1657 T2504 T2502 prep of,absence
R1658 T2505 T2506 amod coordinated,progression
R1659 T2506 T2504 pobj progression,of
R1660 T2507 T2506 amod spermatogenic,progression
R1661 T2508 T2502 prep beyond,absence
R1662 T2509 T2510 det this,stage
R1663 T2510 T2508 pobj stage,beyond
R1664 T2511 T2503 acomp indicative,is
R1665 T2512 T2511 prep of,indicative
R1666 T2513 T2514 det a,arrest
R1667 T2514 T2512 pobj arrest,of
R1668 T2515 T2514 compound pachytene,arrest
R1669 T2516 T2503 punct .,is
R1670 T2518 T2519 nsubjpass This,revealed
R1671 T2520 T2519 auxpass was,revealed
R1672 T2521 T2522 advmod more,clearly
R1673 T2522 T2519 advmod clearly,revealed
R1674 T2523 T2519 agent by,revealed
R1675 T2524 T2525 compound chromosome,analysis
R1676 T2525 T2523 pobj analysis,by
R1677 T2526 T2527 punct (,see
R1678 T2527 T2519 parataxis see,revealed
R1679 T2528 T2527 advmod below,see
R1680 T2529 T2527 punct ),see
R1681 T2530 T2519 punct .,revealed
R1682 T2532 T2533 det Some,sections
R1683 T2533 T2534 nsubj sections,contained
R1684 T2535 T2533 prep of,sections
R1685 T2536 T2537 amod adult,tubules
R1686 T2537 T2535 pobj tubules,of
R1687 T2538 T2537 amod seminiferous,tubules
R1688 T2539 T2540 amod postmeiotic,spermatids
R1689 T2540 T2534 dobj spermatids,contained
R1690 T2541 T2542 punct (,3G
R1691 T2542 T2534 parataxis 3G,contained
R1692 T2543 T2542 compound Figure,3G
R1693 T2544 T2542 punct ),3G
R1694 T2545 T2534 punct ", ",contained
R1695 T2546 T2547 mark although,saw
R1696 T2547 T2534 advcl saw,contained
R1697 T2548 T2547 nsubj we,saw
R1698 T2549 T2550 det no,sperm
R1699 T2550 T2547 dobj sperm,saw
R1700 T2551 T2550 amod motile,sperm
R1701 T2552 T2550 amod epididymal,sperm
R1702 T2553 T2534 punct .,contained
R1703 T2555 T2556 det These,defects
R1704 T2556 T2559 nsubj defects,stand
R1705 T2557 T2556 amod drastic,defects
R1706 T2558 T2556 amod meiotic,defects
R1707 T2560 T2559 prep in,stand
R1708 T2561 T2560 pobj contrast,in
R1709 T2562 T2561 prep to,contrast
R1710 T2563 T2562 pobj yeast,to
R1711 T2564 T2563 cc and,yeast
R1712 T2565 T2566 compound C.,elegans
R1713 T2566 T2563 conj elegans,yeast
R1714 T2567 T2563 punct ", ",yeast
R1715 T2568 T2569 prep in,has
R1716 T2569 T2563 relcl has,yeast
R1717 T2570 T2568 pobj which,in
R1718 T2571 T2569 nsubj deletion,has
R1719 T2572 T2571 prep of,deletion
R1720 T2573 T2572 pobj Pch2,of
R1721 T2574 T2573 advmod alone,Pch2
R1722 T2575 T2576 amod minor,effects
R1723 T2576 T2569 dobj effects,has
R1724 T2577 T2576 prep on,effects
R1725 T2578 T2579 compound spore,gamete
R1726 T2579 T2581 compound gamete,development
R1727 T2580 T2579 punct /,gamete
R1728 T2581 T2577 pobj development,on
R1729 T2582 T2583 punct [,8
R1730 T2583 T2569 parataxis 8,has
R1731 T2584 T2583 nummod 2,8
R1732 T2585 T2583 punct ",",8
R1733 T2586 T2583 punct ],8
R1734 T2587 T2559 punct .,stand
R1742 T2968 T2969 npadvmod TRIP13,Deficient
R1743 T2969 T2971 amod Deficient,Meiocytes
R1744 T2970 T2969 punct -,Deficient
R1745 T2971 T2972 nsubj Meiocytes,Undergo
R1746 T2973 T2974 amod Homologous,Synapsis
R1747 T2974 T2972 dobj Synapsis,Undergo
R1748 T2975 T2974 compound Chromosome,Synapsis
R1749 T2976 T2972 prep Despite,Undergo
R1750 T2977 T2978 det the,Presence
R1751 T2978 T2976 pobj Presence,Despite
R1752 T2979 T2978 prep of,Presence
R1753 T2980 T2981 amod Unrepaired,DSBs
R1754 T2981 T2979 pobj DSBs,of
R1755 T2982 T2978 prep in,Presence
R1756 T2983 T2982 pobj Pachynema,in
R1757 T2985 T2986 aux To,characterize
R1758 T2986 T2988 advcl characterize,immunostained
R1759 T2987 T2986 advmod better,characterize
R1760 T2989 T2990 det the,degree
R1761 T2990 T2986 dobj degree,characterize
R1762 T2991 T2990 prep of,degree
R1763 T2992 T2993 amod meiotic,progression
R1764 T2993 T2991 pobj progression,of
R1765 T2994 T2990 prep in,degree
R1766 T2995 T2996 compound Trip13Gt,Gt
R1767 T2996 T2998 compound Gt,spermatocytes
R1768 T2997 T2996 punct /,Gt
R1769 T2998 T2994 pobj spermatocytes,in
R1770 T2999 T2988 punct ", ",immunostained
R1771 T3000 T2988 nsubj we,immunostained
R1772 T3001 T3002 compound chromosome,spreads
R1773 T3002 T2988 dobj spreads,immunostained
R1774 T3003 T3002 prep for,spreads
R1775 T3004 T3003 pobj SYCP3,for
R1776 T3005 T3004 cc and,SYCP3
R1777 T3006 T3004 conj SYCP1,SYCP3
R1778 T3007 T3004 punct ", ",SYCP3
R1779 T3008 T3004 appos components,SYCP3
R1780 T3009 T3008 prep of,components
R1781 T3010 T3011 det the,elements
R1782 T3011 T3009 pobj elements,of
R1783 T3012 T3013 amod axial,lateral
R1784 T3013 T3011 amod lateral,elements
R1785 T3014 T3013 punct /,lateral
R1786 T3015 T3011 cc and,elements
R1787 T3016 T3017 amod transverse,filaments
R1788 T3017 T3011 conj filaments,elements
R1789 T3018 T3011 punct ", ",elements
R1790 T3019 T3011 advmod respectively,elements
R1791 T3020 T3011 punct ", ",elements
R1792 T3021 T3011 prep of,elements
R1793 T3022 T3023 det the,complex
R1794 T3023 T3021 pobj complex,of
R1795 T3024 T3023 amod synaptonemal,complex
R1796 T3025 T3023 punct (,complex
R1797 T3026 T3023 appos SC,complex
R1798 T3027 T2988 punct ),immunostained
R1799 T3028 T2988 punct .,immunostained
R1800 T3030 T3031 compound Pachytene,nuclei
R1801 T3031 T3033 nsubj nuclei,assemble
R1802 T3032 T3031 compound spermatocyte,nuclei
R1803 T3034 T3031 prep from,nuclei
R1804 T3035 T3036 amod postpubertal,testes
R1805 T3036 T3034 pobj testes,from
R1806 T3037 T3036 compound mutant,testes
R1807 T3038 T3033 aux could,assemble
R1808 T3039 T3040 amod normal,cores
R1809 T3040 T3033 dobj cores,assemble
R1810 T3041 T3040 compound SC,cores
R1811 T3042 T3033 cc and,assemble
R1812 T3043 T3033 conj exhibited,assemble
R1813 T3044 T3045 amod full,synapsis
R1814 T3045 T3043 dobj synapsis,exhibited
R1815 T3046 T3045 prep of,synapsis
R1816 T3047 T3046 pobj chromosomes,of
R1817 T3048 T3049 mark as,judged
R1818 T3049 T3043 advcl judged,exhibited
R1819 T3050 T3049 prep by,judged
R1820 T3051 T3050 pcomp colabeling,by
R1821 T3052 T3051 prep of,colabeling
R1822 T3053 T3052 pobj SYCP1,of
R1823 T3054 T3053 cc and,SYCP1
R1824 T3055 T3053 conj SYCP3,SYCP1
R1825 T3056 T3051 prep along,colabeling
R1826 T3057 T3058 det the,lengths
R1827 T3058 T3056 pobj lengths,along
R1828 T3059 T3058 amod full,lengths
R1829 T3060 T3058 prep of,lengths
R1830 T3061 T3062 det all,autosomes
R1831 T3062 T3060 pobj autosomes,of
R1832 T3063 T3064 punct (,4A
R1833 T3064 T3051 parataxis 4A,colabeling
R1834 T3065 T3064 compound Figure,4A
R1835 T3066 T3064 punct ),4A
R1836 T3067 T3033 punct .,assemble
R1837 T3069 T3070 advmod Additionally,synapsed
R1838 T3071 T3070 punct ", ",synapsed
R1839 T3072 T3073 det the,chromosomes
R1840 T3073 T3070 nsubjpass chromosomes,synapsed
R1841 T3074 T3073 nmod X,chromosomes
R1842 T3075 T3074 cc and,X
R1843 T3076 T3074 conj Y,X
R1844 T3077 T3070 auxpass were,synapsed
R1845 T3078 T3070 advmod normally,synapsed
R1846 T3079 T3070 prep at,synapsed
R1847 T3080 T3081 poss their,region
R1848 T3081 T3079 pobj region,at
R1849 T3082 T3081 amod pseudoautosomal,region
R1850 T3083 T3070 punct .,synapsed
R1851 T3085 T3086 advmod More,spermatocytes
R1852 T3086 T3094 nsubj spermatocytes,contained
R1853 T3087 T3086 amod prepubertal,spermatocytes
R1854 T3088 T3086 punct (,spermatocytes
R1855 T3089 T3090 nummod 17.5,d
R1856 T3090 T3091 nmod d,postpartum
R1857 T3091 T3086 nmod postpartum,spermatocytes
R1858 T3092 T3086 punct ),spermatocytes
R1859 T3093 T3086 compound mutant,spermatocytes
R1860 T3095 T3096 amod asynaptic,chromosomes
R1861 T3096 T3094 dobj chromosomes,contained
R1862 T3097 T3095 cc or,asynaptic
R1863 T3098 T3099 advmod terminally,asynapsed
R1864 T3099 T3095 conj asynapsed,asynaptic
R1865 T3100 T3094 prep than,contained
R1866 T3101 T3102 npadvmod age,matched
R1867 T3102 T3104 amod matched,controls
R1868 T3103 T3102 punct -,matched
R1869 T3104 T3100 pobj controls,than
R1870 T3105 T3106 punct (,4B
R1871 T3106 T3094 parataxis 4B,contained
R1872 T3107 T3108 nummod 62.5,%
R1873 T3108 T3106 dep %,4B
R1874 T3109 T3108 cc versus,%
R1875 T3110 T3111 nummod 25,%
R1876 T3111 T3108 conj %,%
R1877 T3112 T3108 punct ", ",%
R1878 T3113 T3108 advmod respectively,%
R1879 T3114 T3106 punct ;,4B
R1880 T3115 T3106 compound Figure,4B
R1881 T3116 T3106 punct ),4B
R1882 T3117 T3094 punct .,contained
R1883 T3119 T3120 nsubj We,attribute
R1884 T3121 T3120 dobj this,attribute
R1885 T3122 T3120 prep to,attribute
R1886 T3123 T3124 det a,delay
R1887 T3124 T3122 pobj delay,to
R1888 T3125 T3124 prep in,delay
R1889 T3126 T3127 det the,wave
R1890 T3127 T3125 pobj wave,in
R1891 T3128 T3127 amod first,wave
R1892 T3129 T3127 prep of,wave
R1893 T3130 T3131 amod postnatal,spermatogenesis
R1894 T3131 T3129 pobj spermatogenesis,of
R1895 T3132 T3133 punct (,2D
R1896 T3133 T3124 parataxis 2D,delay
R1897 T3134 T3133 compound Figure,2D
R1898 T3135 T3133 cc and,2D
R1914 T3151 T3120 punct .,attribute
R1915 T3153 T3154 advmod Nevertheless,suggested
R1916 T3155 T3154 punct ", ",suggested
R1917 T3156 T3157 mark since,progress
R1918 T3157 T3154 advcl progress,suggested
R1919 T3158 T3159 compound Trip13Gt,Gt
R1920 T3159 T3161 compound Gt,spermatocytes
R1921 T3160 T3159 punct /,Gt
R1922 T3161 T3157 nsubj spermatocytes,progress
R1923 T3162 T3157 prep to,progress
R1924 T3163 T3162 pobj pachynema,to
R1925 T3164 T3157 prep with,progress
R1926 T3165 T3166 det no,abnormalities
R1927 T3166 T3164 pobj abnormalities,with
R1928 T3167 T3166 amod gross,abnormalities
R1929 T3168 T3166 compound SC,abnormalities
R1930 T3169 T3157 punct ", ",progress
R1931 T3170 T3157 cc and,progress
R1932 T3171 T3172 nsubjpass oocytes,eliminated
R1933 T3172 T3157 conj eliminated,progress
R1934 T3173 T3172 auxpass were,eliminated
R1935 T3174 T3175 advmod soon,after
R1936 T3175 T3172 prep after,eliminated
R1937 T3176 T3175 pobj birth,after
R1938 T3177 T3178 punct (,characteristic
R1939 T3178 T3172 parataxis characteristic,eliminated
R1940 T3179 T3178 det a,characteristic
R1941 T3180 T3178 prep of,characteristic
R1942 T3181 T3182 compound DNA,repair
R1943 T3182 T3183 compound repair,mutants
R1944 T3183 T3180 pobj mutants,of
R1945 T3184 T3185 punct [,13
R1946 T3185 T3178 parataxis 13,characteristic
R1947 T3186 T3185 punct ],13
R1948 T3187 T3178 punct ),characteristic
R1949 T3188 T3154 punct ", ",suggested
R1950 T3189 T3154 nsubj this,suggested
R1951 T3190 T3191 mark that,are
R1952 T3191 T3154 ccomp are,suggested
R1953 T3192 T3193 amod unrepaired,DSBs
R1954 T3193 T3191 nsubj DSBs,are
R1955 T3194 T3191 acomp responsible,are
R1956 T3195 T3194 prep for,responsible
R1957 T3196 T3197 amod eventual,arrest
R1958 T3197 T3195 pobj arrest,for
R1959 T3198 T3197 amod meiotic,arrest
R1960 T3199 T3197 cc and,arrest
R1961 T3200 T3197 conj elimination,arrest
R1962 T3201 T3154 punct .,suggested
R2000 T3288 T3282 parataxis S2A,presence
R2001 T3289 T3288 compound Figure,S2A
R2002 T3290 T3288 cc and,S2A
R2003 T3291 T3288 conj S2B,S2A
R2004 T3292 T3288 punct ),S2A
R2005 T3293 T3282 punct ", ",presence
R2006 T3294 T3295 dep which,reflects
R2007 T3295 T3282 relcl reflects,presence
R2008 T3296 T3297 det the,presence
R2009 T3297 T3295 dobj presence,reflects
R2010 T3298 T3297 prep of,presence
R2011 T3299 T3300 advmod meiotically,induced
R2012 T3300 T3301 amod induced,DSBs
R2013 T3301 T3298 pobj DSBs,of
R2014 T3302 T3303 punct [,18
R2015 T3303 T3269 parataxis 18,appeared
R2016 T3304 T3303 punct ],18
R2017 T3305 T3269 punct .,appeared
R2018 T3307 T3308 nsubj RAD51,was
R2019 T3309 T3307 cc and,RAD51
R2020 T3310 T3309 punct /,and
R2021 T3311 T3309 cc or,and
R2022 T3312 T3307 conj DMC1,RAD51
R2023 T3313 T3307 punct ", ",RAD51
R2024 T3314 T3307 appos components,RAD51
R2025 T3315 T3314 prep of,components
R2026 T3316 T3317 amod early,recombination
R2027 T3317 T3318 compound recombination,nodules
R2028 T3318 T3315 pobj nodules,of
R2029 T3319 T3318 punct (,nodules
R2030 T3320 T3318 appos ERNs,nodules
R2031 T3321 T3308 punct ),was
R2032 T3322 T3308 punct ", ",was
R2033 T3323 T3308 advmod also,was
R2034 T3324 T3308 acomp present,was
R2035 T3325 T3308 prep as,was
R2036 T3326 T3327 amod abundant,foci
R2037 T3327 T3325 pobj foci,as
R2038 T3328 T3308 prep in,was
R2039 T3329 T3330 compound Trip13Gt,Gt
R2040 T3330 T3332 compound Gt,spermatocytes
R2041 T3331 T3330 punct /,Gt
R2042 T3332 T3328 pobj spermatocytes,in
R2043 T3333 T3332 compound zygotene,spermatocytes
R2044 T3334 T3335 punct (,data
R2045 T3335 T3308 parataxis data,was
R2046 T3336 T3335 amod unpublished,data
R2047 T3337 T3335 punct ;,data
R2048 T3338 T3339 det the,antibody
R2049 T3339 T3341 nsubj antibody,cross-reacts
R2050 T3340 T3339 amod anti-RAD51,antibody
R2051 T3341 T3335 ccomp cross-reacts,data
R2052 T3342 T3341 prep with,cross-reacts
R2053 T3343 T3342 pobj DMC1,with
R2054 T3344 T3335 punct ),data
R2055 T3345 T3308 punct ", ",was
R2056 T3346 T3308 advcl indicating,was
R2057 T3347 T3348 mark that,initiated
R2058 T3348 T3346 ccomp initiated,indicating
R2059 T3349 T3350 amod recombinational,repair
R2060 T3350 T3348 nsubjpass repair,initiated
R2061 T3351 T3350 prep of,repair
R2062 T3352 T3351 pobj DSBs,of
R2063 T3353 T3348 auxpass is,initiated
R2064 T3354 T3308 punct .,was
R2065 T3356 T3357 det The,complex
R2066 T3357 T3359 nsubj complex,appeared
R2067 T3358 T3357 compound cohesin,complex
R2068 T3360 T3357 punct ", ",complex
R2069 T3361 T3362 dep which,is
R2070 T3362 T3357 relcl is,complex
R2071 T3363 T3362 acomp essential,is
R2072 T3364 T3363 prep for,essential
R2073 T3365 T3364 pobj completion,for
R2074 T3366 T3365 cc and,completion
R2075 T3367 T3366 punct /,and
R2076 T3368 T3366 cc or,and
R2077 T3369 T3365 conj maintenance,completion
R2078 T3370 T3365 prep of,completion
R2079 T3371 T3372 amod synaptic,associations
R2080 T3372 T3370 pobj associations,of
R2081 T3373 T3359 punct ", ",appeared
R2082 T3374 T3375 aux to,assemble
R2083 T3375 T3359 xcomp assemble,appeared
R2084 T3376 T3375 advmod normally,assemble
R2085 T3377 T3378 mark as,judged
R2086 T3378 T3375 advcl judged,assemble
R2087 T3379 T3378 prep by,judged
R2088 T3380 T3379 pcomp immunolabeling,by
R2089 T3381 T3380 prep for,immunolabeling
R2090 T3382 T3383 det the,STAG3
R2091 T3383 T3381 pobj STAG3,for
R2092 T3384 T3385 npadvmod meiosis,specific
R2093 T3385 T3383 amod specific,STAG3
R2094 T3386 T3385 punct -,specific
R2095 T3387 T3383 compound cohesins,STAG3
R2096 T3388 T3389 punct (,S2C
R2097 T3389 T3383 parataxis S2C,STAG3
R2098 T3390 T3389 compound Figure,S2C
R2099 T3391 T3389 cc and,S2C
R2100 T3392 T3389 conj S2D,S2C
R2101 T3393 T3389 punct ),S2C
R2102 T3394 T3383 cc and,STAG3
R2103 T3395 T3383 conj REC8,STAG3
R2104 T3396 T3397 punct (,data
R2105 T3397 T3395 meta data,REC8
R2106 T3398 T3397 amod unpublished,data
R2107 T3399 T3397 punct ),data
R2108 T3400 T3359 punct .,appeared
R2109 T3402 T3403 mark Because,localizes
R2110 T3403 T3406 advcl localizes,tested
R2111 T3404 T3405 compound yeast,PCH2
R2112 T3405 T3403 nsubj PCH2,localizes
R2113 T3407 T3403 prep to,localizes
R2114 T3408 T3407 pobj telomeres,to
R2115 T3409 T3403 prep in,localizes
R2116 T3410 T3411 det a,manner
R2117 T3411 T3409 pobj manner,in
R2118 T3412 T3413 npadvmod Sir3p,dependent
R2119 T3413 T3411 amod dependent,manner
R2120 T3414 T3413 punct -,dependent
R2121 T3415 T3406 punct ", ",tested
R2122 T3416 T3406 nsubj we,tested
R2123 T3417 T3406 prep for,tested
R2124 T3418 T3419 amod possible,defects
R2125 T3419 T3417 pobj defects,for
R2126 T3420 T3419 compound telomere,defects
R2127 T3421 T3406 prep by,tested
R2128 T3422 T3421 pcomp immunolabeling,by
R2129 T3423 T3422 prep for,immunolabeling
R2130 T3424 T3423 pobj TRF2,for
R2131 T3425 T3424 punct ", ",TRF2
R2132 T3426 T3427 det a,component
R2133 T3427 T3424 appos component,TRF2
R2134 T3428 T3427 prep of,component
R2135 T3429 T3430 det a,complex
R2136 T3430 T3428 pobj complex,of
R2137 T3431 T3430 compound protein,complex
R2138 T3432 T3433 dep that,plays
R2139 T3433 T3430 relcl plays,complex
R2140 T3434 T3435 det an,role
R2141 T3435 T3433 dobj role,plays
R2142 T3436 T3435 amod essential,role
R2143 T3437 T3433 prep in,plays
R2144 T3438 T3439 compound telomere,protection
R2145 T3439 T3437 pobj protection,in
R2146 T3440 T3441 punct [,19
R2147 T3441 T3406 parataxis 19,tested
R2148 T3442 T3441 punct ],19
R2149 T3443 T3406 punct .,tested
R2150 T3445 T3446 nsubjpass It,localized
R2151 T3447 T3446 auxpass was,localized
R2152 T3448 T3446 prep to,localized
R2153 T3449 T3448 pobj telomeres,to
R2154 T3450 T3449 prep of,telomeres
R2155 T3451 T3452 preconj both,synapsed
R2156 T3452 T3454 amod synapsed,chromosomes
R2157 T3453 T3452 advmod fully,synapsed
R2158 T3454 T3450 pobj chromosomes,of
R2159 T3455 T3452 cc and,synapsed
R2160 T3456 T3457 advmod telomerically,asynaptic
R2161 T3457 T3452 conj asynaptic,synapsed
R2162 T3458 T3454 compound mutant,chromosomes
R2163 T3459 T3460 punct (,S2E
R2164 T3460 T3446 parataxis S2E,localized
R2165 T3461 T3460 compound Figure,S2E
R2166 T3462 T3460 cc and,S2E
R2167 T3463 T3460 conj S2F,S2E
R2168 T3464 T3460 punct ),S2E
R2169 T3465 T3446 punct .,localized
R2170 T3467 T3468 nsubj Defects,became
R2171 T3469 T3467 prep in,Defects
R2172 T3470 T3471 compound DSB,repair
R2173 T3471 T3469 pobj repair,in
R2174 T3472 T3468 acomp apparent,became
R2175 T3473 T3468 prep in,became
R2176 T3474 T3473 pobj pachynema,in
R2177 T3475 T3468 prep upon,became
R2178 T3476 T3475 pobj probing,upon
R2179 T3477 T3476 prep of,probing
R2180 T3478 T3479 compound mutant,nuclei
R2181 T3479 T3477 pobj nuclei,of
R2182 T3480 T3479 compound spermatocyte,nuclei
R2183 T3481 T3476 prep with,probing
R2184 T3482 T3481 pobj antibodies,with
R2185 T3483 T3482 prep against,antibodies
R2186 T3484 T3483 pobj molecules,against
R2187 T3485 T3484 acl involved,molecules
R2188 T3486 T3485 prep in,involved
R2189 T3487 T3488 amod various,stages
R2190 T3488 T3486 pobj stages,in
R2191 T3489 T3488 prep of,stages
R2192 T3490 T3489 pobj recombination,of
R2193 T3491 T3468 punct .,became
R2194 T3493 T3494 prep In,persisted
R2195 T3495 T3496 punct >,99
R2196 T3496 T3497 nummod 99,%
R2197 T3497 T3493 pobj %,In
R2198 T3498 T3497 prep of,%
R2199 T3499 T3500 compound Trip13Gt,Gt
R2200 T3500 T3502 compound Gt,chromosome
R2201 T3501 T3500 punct /,Gt
R2202 T3502 T3503 compound chromosome,spreads
R2203 T3503 T3498 pobj spreads,of
R2204 T3504 T3494 punct ", ",persisted
R2205 T3505 T3506 compound BLM,helicase
R2206 T3506 T3494 nsubj helicase,persisted
R2207 T3507 T3508 punct (,4C
R2208 T3508 T3506 parataxis 4C,helicase
R2209 T3509 T3508 compound Figure,4C
R2210 T3510 T3508 cc and,4C
R2211 T3511 T3508 conj 4D,4C
R2212 T3512 T3508 punct ),4C
R2213 T3513 T3506 punct ", ",helicase
R2214 T3514 T3515 compound RAD51,DMC1
R2215 T3515 T3506 conj DMC1,helicase
R2216 T3516 T3515 punct /,DMC1
R2217 T3517 T3518 punct (,4E
R2218 T3518 T3515 parataxis 4E,DMC1
R2219 T3519 T3518 compound Figure,4E
R2220 T3520 T3518 cc and,4E
R2221 T3521 T3518 conj 4F,4E
R2222 T3522 T3518 punct ),4E
R2223 T3523 T3515 punct ", ",DMC1
R2224 T3524 T3515 conj γH2AX,DMC1
R2225 T3525 T3526 punct (,4G
R2226 T3526 T3524 parataxis 4G,γH2AX
R2227 T3527 T3526 compound Figure,4G
R2228 T3528 T3526 cc and,4G
R2229 T3529 T3526 conj 4H,4G
R2230 T3530 T3526 punct ),4G
R2231 T3531 T3524 punct ", ",γH2AX
R2232 T3532 T3524 cc and,γH2AX
R2233 T3533 T3524 conj TOPBP1,γH2AX
R2234 T3534 T3533 punct (,TOPBP1
R2235 T3535 T3536 compound Figure,4I
R2236 T3536 T3533 parataxis 4I,TOPBP1
R2237 T3537 T3536 cc and,4I
R2238 T3538 T3536 conj 4J,4I
R2239 T3539 T3533 punct ),TOPBP1
R2240 T3540 T3506 appos all,helicase
R2241 T3541 T3494 advmod abnormally,persisted
R2242 T3542 T3494 prep on,persisted
R2243 T3543 T3544 amod synapsed,chromosomes
R2244 T3544 T3542 pobj chromosomes,on
R2245 T3545 T3494 punct .,persisted
R2246 T3547 T3548 prep For,contained
R2247 T3549 T3550 compound RAD51,DMC1
R2248 T3550 T3547 pobj DMC1,For
R2249 T3551 T3550 punct /,DMC1
R2250 T3552 T3548 punct ", ",contained
R2251 T3553 T3554 compound mutant,pachytene
R2252 T3554 T3548 nsubj pachytene,contained
R2253 T3555 T3548 dep spermatocytes,contained
R2254 T3556 T3557 quantmod 138,6
R2255 T3557 T3559 nummod 6,foci
R2256 T3558 T3557 punct ±,6
R2257 T3559 T3548 dobj foci,contained
R2258 T3560 T3559 punct (,foci
R2259 T3561 T3559 prep compared,foci
R2260 T3562 T3561 prep to,compared
R2261 T3563 T3564 quantmod 11,3
R2262 T3564 T3566 nummod 3,foci
R2263 T3565 T3564 punct ±,3
R2264 T3566 T3562 pobj foci,to
R2265 T3567 T3566 prep in,foci
R2266 T3568 T3569 amod wild,type
R2267 T3569 T3567 pobj type,in
R2268 T3570 T3566 punct ", ",foci
R2269 T3571 T3572 dep most,were
R2270 T3572 T3566 relcl were,foci
R2271 T3573 T3571 prep of,most
R2272 T3574 T3573 pobj which,of
R2273 T3575 T3572 prep on,were
R2274 T3576 T3577 det the,body
R2275 T3577 T3575 pobj body,on
R2276 T3578 T3577 compound XY,body
R2277 T3579 T3559 punct ),foci
R2278 T3580 T3548 punct ", ",contained
R2279 T3581 T3548 advmod down,contained
R2280 T3582 T3581 prep from,down
R2281 T3583 T3584 nummod 218,13
R2282 T3584 T3582 pobj 13,from
R2283 T3585 T3584 punct ±,13
R2284 T3586 T3584 prep in,13
R2285 T3587 T3586 pobj zygonema,in
R2286 T3588 T3584 punct (,13
R2287 T3589 T3584 prep compared,13
R2288 T3590 T3589 prep to,compared
R2289 T3591 T3592 quantmod 220,13
R2290 T3592 T3594 nummod 13,foci
R2291 T3593 T3592 punct ±,13
R2292 T3594 T3590 pobj foci,to
R2293 T3595 T3594 prep in,foci
R2294 T3596 T3597 amod wild,type
R2295 T3597 T3595 pobj type,in
R2296 T3598 T3584 punct ),13
R2297 T3599 T3548 punct .,contained
R2298 T3601 T3602 nsubj TOPBP1,is
R2299 T3603 T3604 det a,protein
R2300 T3604 T3602 attr protein,is
R2301 T3605 T3606 compound DNA,damage
R2302 T3606 T3607 compound damage,checkpoint
R2303 T3607 T3604 compound checkpoint,protein
R2304 T3608 T3607 punct –,checkpoint
R2305 T3609 T3604 acl involved,protein
R2306 T3610 T3609 prep in,involved
R2307 T3611 T3612 compound ATM,protein
R2308 T3612 T3613 npadvmod protein,dependent
R2309 T3613 T3615 amod dependent,activation
R2310 T3614 T3613 punct –,dependent
R2311 T3615 T3610 pobj activation,in
R2312 T3616 T3615 prep of,activation
R2313 T3617 T3618 compound ATR,protein
R2314 T3618 T3616 pobj protein,of
R2315 T3619 T3620 punct [,21
R2316 T3620 T3602 parataxis 21,is
R2317 T3621 T3620 nummod 20,21
R2318 T3622 T3620 punct ",",21
R2319 T3623 T3620 punct ],21
R2320 T3624 T3602 punct .,is
R2321 T3626 T3627 nsubj It,binds
R2322 T3628 T3627 dobj sites,binds
R2323 T3629 T3628 prep of,sites
R2324 T3630 T3629 pobj DSBs,of
R2325 T3631 T3628 cc and,sites
R2326 T3632 T3633 amod unsynapsed,regions
R2327 T3633 T3628 conj regions,sites
R2328 T3634 T3633 prep of,regions
R2329 T3635 T3636 amod meiotic,chromosomes
R2330 T3636 T3634 pobj chromosomes,of
R2331 T3637 T3638 punct [,23
R2332 T3638 T3627 parataxis 23,binds
R2333 T3639 T3638 nummod 22,23
R2334 T3640 T3638 punct ",",23
R2335 T3641 T3638 punct ],23
R2336 T3642 T3627 punct .,binds
R2337 T3644 T3645 nsubjpass BLM,reported
R2338 T3646 T3645 aux has,reported
R2339 T3647 T3645 auxpass been,reported
R2340 T3648 T3649 aux to,colocalize
R2341 T3649 T3645 xcomp colocalize,reported
R2342 T3650 T3649 prep with,colocalize
R2343 T3651 T3652 nmod markers,RPA
R2344 T3652 T3650 pobj RPA,with
R2345 T3653 T3652 punct (,RPA
R2346 T3654 T3652 cc and,RPA
R2347 T3655 T3652 conj MSH4,RPA
R2348 T3656 T3652 punct ),RPA
R2349 T3657 T3652 prep of,RPA
R2350 T3658 T3657 pobj recombination,of
R2351 T3659 T3649 prep at,colocalize
R2352 T3660 T3659 pobj sites,at
R2353 T3661 T3660 amod distinct,sites
R2354 T3662 T3661 prep from,distinct
R2355 T3663 T3662 pobj those,from
R2356 T3664 T3665 dep that,become
R2357 T3665 T3663 relcl become,those
R2358 T3666 T3665 acomp resolved,become
R2359 T3667 T3665 prep as,become
R2360 T3668 T3667 pobj crossovers,as
R2361 T3669 T3668 punct (,crossovers
R2362 T3670 T3668 appos CO,crossovers
R2363 T3671 T3649 punct ),colocalize
R2364 T3672 T3673 punct [,24
R2365 T3673 T3649 parataxis 24,colocalize
R2366 T3674 T3673 punct ],24
R2367 T3675 T3645 punct .,reported
R2368 T3677 T3678 nsubj We,assessed
R2369 T3679 T3678 advmod therefore,assessed
R2370 T3680 T3681 det the,distribution
R2371 T3681 T3678 dobj distribution,assessed
R2372 T3682 T3681 prep of,distribution
R2373 T3683 T3682 pobj RPA,of
R2374 T3684 T3683 punct ", ",RPA
R2375 T3685 T3686 det the,protein
R2376 T3686 T3683 appos protein,RPA
R2377 T3687 T3686 compound ssDNA,protein
R2378 T3688 T3686 compound binding,protein
R2379 T3689 T3686 punct ", ",protein
R2380 T3690 T3691 dep which,is
R2381 T3691 T3686 relcl is,protein
R2382 T3692 T3691 advmod normally,is
R2383 T3693 T3691 acomp present,is
R2384 T3694 T3691 prep at,is
R2385 T3695 T3696 amod focal,sites
R2386 T3696 T3694 pobj sites,at
R2387 T3697 T3696 prep of,sites
R2388 T3698 T3699 amod synapsing,chromosomes
R2389 T3699 T3697 pobj chromosomes,of
R2390 T3700 T3699 amod meiotic,chromosomes
R2391 T3701 T3691 prep before,is
R2392 T3702 T3701 pcomp disappearing,before
R2393 T3703 T3702 prep in,disappearing
R2394 T3704 T3703 pobj mid-pachynema,in
R2395 T3705 T3706 punct [,25
R2396 T3706 T3678 parataxis 25,assessed
R2397 T3707 T3706 punct ],25
R2398 T3708 T3678 punct .,assessed
R2399 T3710 T3711 nsubjpass It,thought
R2400 T3712 T3711 auxpass is,thought
R2401 T3713 T3714 aux to,bind
R2402 T3714 T3711 xcomp bind,thought
R2403 T3715 T3716 compound D,loops
R2404 T3716 T3714 dobj loops,bind
R2405 T3717 T3716 punct -,loops
R2406 T3718 T3716 prep of,loops
R2407 T3719 T3720 compound recombination,intermediates
R2408 T3720 T3718 pobj intermediates,of
R2409 T3721 T3722 punct [,26
R2410 T3722 T3711 parataxis 26,thought
R2411 T3723 T3722 punct ],26
R2412 T3724 T3711 punct .,thought
R2413 T3726 T3727 nsubj RPA,persisted
R2414 T3728 T3727 advmod also,persisted
R2415 T3729 T3727 prep on,persisted
R2416 T3730 T3731 compound pachytene,chromosomes
R2417 T3731 T3729 pobj chromosomes,on
R2418 T3732 T3731 compound mutant,chromosomes
R2419 T3733 T3734 punct (,4K
R2420 T3734 T3727 parataxis 4K,persisted
R2421 T3735 T3734 compound Figure,4K
R2422 T3736 T3734 cc and,4K
R2423 T3737 T3734 conj 4L,4K
R2424 T3738 T3734 punct ),4K
R2425 T3739 T3727 punct .,persisted
R2426 T3741 T3742 det These,data
R2427 T3742 T3743 nsubj data,indicate
R2428 T3744 T3745 mark that,remain
R2429 T3745 T3743 ccomp remain,indicate
R2430 T3746 T3747 amod unrepaired,DSBs
R2431 T3747 T3745 nsubj DSBs,remain
R2432 T3748 T3747 punct ", ",DSBs
R2433 T3749 T3747 cc or,DSBs
R2434 T3750 T3751 amod unresolved,intermediates
R2435 T3751 T3747 conj intermediates,DSBs
R2436 T3752 T3751 compound recombination,intermediates
R2437 T3753 T3745 punct ", ",remain
R2438 T3754 T3745 prep in,remain
R2439 T3755 T3754 pobj pachynema,in
R2440 T3756 T3745 cc and,remain
R2441 T3757 T3745 conj activate,remain
R2442 T3758 T3759 det a,system
R2443 T3759 T3757 dobj system,activate
R2444 T3760 T3761 compound DNA,damage
R2445 T3761 T3762 compound damage,checkpoint
R2446 T3762 T3759 compound checkpoint,system
R2447 T3763 T3743 punct .,indicate
R2448 T3765 T3766 nsubjpass It,noted
R2449 T3767 T3766 aux should,noted
R2450 T3768 T3766 auxpass be,noted
R2451 T3769 T3770 mark that,stained
R2452 T3770 T3766 ccomp stained,noted
R2453 T3771 T3770 nsubjpass chromosomes,stained
R2454 T3772 T3771 acl affected,chromosomes
R2455 T3773 T3772 agent by,affected
R2456 T3774 T3775 amod meiotic,inactivation
R2457 T3775 T3773 pobj inactivation,by
R2458 T3776 T3777 compound sex,chromosome
R2459 T3777 T3775 compound chromosome,inactivation
R2460 T3778 T3775 punct (,inactivation
R2461 T3779 T3775 appos MSCI,inactivation
R2462 T3780 T3775 punct ),inactivation
R2463 T3781 T3775 cc and,inactivation
R2464 T3782 T3783 amod meiotic,silencing
R2465 T3783 T3775 conj silencing,inactivation
R2466 T3784 T3783 prep of,silencing
R2467 T3785 T3786 amod unpaired,chromatin
R2468 T3786 T3784 pobj chromatin,of
R2469 T3787 T3783 punct (,silencing
R2470 T3788 T3783 appos MSUC,silencing
R2471 T3789 T3770 punct ),stained
R2472 T3790 T3770 auxpass are,stained
R2473 T3791 T3770 advmod heavily,stained
R2474 T3792 T3770 agent by,stained
R2475 T3793 T3792 pobj antibodies,by
R2476 T3794 T3770 prep for,stained
R2477 T3795 T3796 amod several,molecules
R2478 T3796 T3794 pobj molecules,for
R2479 T3797 T3798 compound DSB,repair
R2480 T3798 T3799 npadvmod repair,associated
R2481 T3799 T3796 amod associated,molecules
R2482 T3800 T3799 punct -,associated
R2483 T3801 T3796 punct ", ",molecules
R2484 T3802 T3796 prep including,molecules
R2485 T3803 T3802 pobj γH2AX,including
R2486 T3804 T3766 punct .,noted
R2487 T3806 T3807 compound H2AX,phosphorylation
R2488 T3807 T3808 nsubjpass phosphorylation,conducted
R2489 T3809 T3807 prep due,phosphorylation
R2490 T3810 T3809 pcomp to,due
R2491 T3811 T3809 pobj MSCI,due
R2492 T3812 T3811 cc and,MSCI
R2493 T3813 T3811 conj MSUC,MSCI
R2494 T3814 T3808 auxpass is,conducted
R2495 T3815 T3808 prep by,conducted
R2496 T3816 T3815 pobj ATR,by
R2497 T3817 T3816 punct ", ",ATR
R2498 T3818 T3816 cc not,ATR
R2499 T3819 T3816 conj ATM,ATR
R2500 T3820 T3821 punct [,27
R2501 T3821 T3808 parataxis 27,conducted
R2502 T3822 T3823 punct –,29
R2503 T3823 T3821 prep 29,27
R2504 T3824 T3821 punct ],27
R2505 T3825 T3808 punct .,conducted
R2506 T3827 T3828 mark Since,synapsed
R2507 T3828 T3833 advcl synapsed,is
R2508 T3829 T3830 compound mutant,chromosomes
R2509 T3830 T3828 nsubjpass chromosomes,synapsed
R2510 T3831 T3828 auxpass are,synapsed
R2511 T3832 T3828 advmod fully,synapsed
R2512 T3834 T3828 punct ", ",synapsed
R2513 T3835 T3828 cc and,synapsed
R2514 T3836 T3837 nsubjpass MSUC,known
R2515 T3837 T3828 conj known,synapsed
R2516 T3838 T3837 auxpass is,known
R2517 T3839 T3840 aux to,occur
R2518 T3840 T3837 xcomp occur,known
R2519 T3841 T3842 advmod only,as
R2520 T3842 T3840 prep as,occur
R2521 T3843 T3844 det a,result
R2522 T3844 T3842 pobj result,as
R2523 T3845 T3844 prep of,result
R2524 T3846 T3845 pobj asynapsis,of
R2525 T3847 T3833 punct ", ",is
R2526 T3848 T3849 det the,decoration
R2527 T3849 T3833 nsubj decoration,is
R2528 T3850 T3849 prep of,decoration
R2529 T3851 T3852 compound Trip13Gt,Gt
R2530 T3852 T3854 compound Gt,chromosomes
R2531 T3853 T3852 punct /,Gt
R2532 T3854 T3850 pobj chromosomes,of
R2533 T3855 T3849 prep with,decoration
R2534 T3856 T3857 compound DNA,repair
R2535 T3857 T3858 compound repair,markers
R2536 T3858 T3855 pobj markers,with
R2537 T3859 T3860 advmod probably,attributable
R2538 T3860 T3833 acomp attributable,is
R2539 T3861 T3860 prep to,attributable
R2540 T3862 T3863 amod incomplete,repair
R2541 T3863 T3861 pobj repair,to
R2542 T3864 T3863 compound DNA,repair
R2543 T3865 T3866 advmod rather,than
R2544 T3866 T3863 cc than,repair
R2545 T3867 T3868 amod transcriptional,silencing
R2546 T3868 T3863 conj silencing,repair
R2547 T3869 T3833 punct .,is
R2548 T3871 T3872 advcl Consistent,observed
R2549 T3873 T3871 prep with,Consistent
R2550 T3874 T3875 det the,presence
R2551 T3875 T3873 pobj presence,with
R2552 T3876 T3875 prep of,presence
R2553 T3877 T3878 amod rare,spermatocytes
R2554 T3878 T3876 pobj spermatocytes,of
R2555 T3879 T3880 punct (,%
R2556 T3880 T3877 parataxis %,rare
R2557 T3881 T3882 punct <,1
R2558 T3882 T3880 nummod 1,%
R2559 T3883 T3880 punct ),%
R2560 T3884 T3885 compound Trip13Gt,Gt
R2561 T3885 T3878 compound Gt,spermatocytes
R2562 T3886 T3885 punct /,Gt
R2563 T3887 T3878 compound pachytene,spermatocytes
R2564 T3888 T3878 amod devoid,spermatocytes
R2565 T3889 T3888 prep of,devoid
R2566 T3890 T3891 amod persistent,markers
R2567 T3891 T3889 pobj markers,of
R2568 T3892 T3893 compound DNA,repair
R2569 T3893 T3891 compound repair,markers
R2570 T3894 T3878 punct ", ",spermatocytes
R2571 T3895 T3878 cc and,spermatocytes
R2572 T3896 T3897 compound testis,histology
R2573 T3897 T3878 conj histology,spermatocytes
R2574 T3898 T3897 acl showing,histology
R2575 T3899 T3900 det some,degree
R2576 T3900 T3898 dobj degree,showing
R2577 T3901 T3900 prep of,degree
R2578 T3902 T3903 amod postmeiotic,progression
R2579 T3903 T3901 pobj progression,of
R2580 T3904 T3905 punct (,3G
R2581 T3905 T3871 parataxis 3G,Consistent
R2582 T3906 T3905 compound Figure,3G
R2583 T3907 T3905 punct ),3G
R2584 T3908 T3872 punct ", ",observed
R2585 T3909 T3872 nsubj we,observed
R2586 T3910 T3911 preconj both,nuclei
R2587 T3911 T3872 dobj nuclei,observed
R2588 T3912 T3911 compound diplotene,nuclei
R2589 T3913 T3914 dep that,lacked
R2590 T3914 T3911 relcl lacked,nuclei
R2591 T3915 T3916 amod autosomal,DMC1
R2592 T3916 T3914 dobj DMC1,lacked
R2593 T3917 T3916 compound RAD51,DMC1
R2594 T3918 T3916 punct /,DMC1
R2595 T3919 T3916 cc and,DMC1
R2596 T3920 T3916 conj γH2AX,DMC1
R2597 T3921 T3922 punct (,S3D
R2598 T3922 T3914 parataxis S3D,lacked
R2599 T3923 T3922 nmod Figure,S3D
R2600 T3924 T3922 nmod S3A,S3D
R2601 T3925 T3922 punct –,S3D
R2602 T3926 T3922 punct ),S3D
R2603 T3927 T3911 punct ", ",nuclei
R2604 T3928 T3911 cc and,nuclei
R2605 T3929 T3928 advmod also,and
R2606 T3930 T3931 nmod metaphase,spreads
R2607 T3931 T3911 conj spreads,nuclei
R2608 T3932 T3930 nummod I,metaphase
R2609 T3933 T3931 prep with,spreads
R2610 T3934 T3935 nummod 20,bivalents
R2611 T3935 T3933 pobj bivalents,with
R2612 T3936 T3937 punct (,S3F
R2613 T3937 T3931 parataxis S3F,spreads
R2614 T3938 T3937 nmod Figure,S3F
R2615 T3939 T3937 nmod S3E,S3F
R2616 T3940 T3937 punct –,S3F
R2617 T3941 T3937 punct ),S3F
R2618 T3942 T3872 punct .,observed
R2619 T3944 T3945 mark Since,be
R2620 T3945 T3949 advcl be,arise
R2621 T3946 T3945 nsubj Trip13Gt,be
R2622 T3947 T3945 aux may,be
R2623 T3948 T3945 neg not,be
R2624 T3950 T3951 det a,null
R2625 T3951 T3945 attr null,be
R2626 T3952 T3951 amod complete,null
R2627 T3953 T3949 punct ", ",arise
R2628 T3954 T3955 det these,spermatocytes
R2629 T3955 T3949 nsubj spermatocytes,arise
R2630 T3956 T3955 nmod diplotene,spermatocytes
R2631 T3957 T3956 cc and,diplotene
R2632 T3958 T3956 conj metaphase,diplotene
R2633 T3959 T3958 nummod I,metaphase
R2634 T3960 T3949 aux might,arise
R2635 T3961 T3949 prep by,arise
R2636 T3962 T3961 pobj virtue,by
R2637 T3963 T3962 prep of,virtue
R2638 T3964 T3963 pcomp having,of
R2639 T3965 T3966 amod sufficient,TRIP13
R2640 T3966 T3964 dobj TRIP13,having
R2641 T3967 T3968 amod wild,type
R2642 T3968 T3966 compound type,TRIP13
R2643 T3969 T3968 punct -,type
R2644 T3970 T3949 punct .,arise
R2647 T4133 T4134 npadvmod CO,Associated
R2648 T4134 T4136 amod Associated,Markers
R2649 T4135 T4134 punct -,Associated
R2650 T4136 T4137 nsubj Markers,Appear
R2651 T4138 T4137 advmod Normally,Appear
R2652 T4139 T4137 prep in,Appear
R2653 T4140 T4141 det the,Absence
R2654 T4141 T4139 pobj Absence,in
R2655 T4142 T4141 prep of,Absence
R2656 T4143 T4142 pobj TRIP13,of
R2657 T4145 T4146 det The,persistence
R2658 T4146 T4147 nsubj persistence,suggests
R2659 T4148 T4146 prep of,persistence
R2660 T4149 T4148 pobj BLM,of
R2661 T4150 T4146 prep on,persistence
R2662 T4151 T4152 compound Trip13Gt,Gt
R2663 T4152 T4154 compound Gt,spermatocyte
R2664 T4153 T4152 punct /,Gt
R2665 T4154 T4155 compound spermatocyte,chromosomes
R2666 T4155 T4150 pobj chromosomes,on
R2667 T4156 T4157 mark that,correspond
R2668 T4157 T4147 ccomp correspond,suggests
R2669 T4158 T4159 advmod at,least
R2670 T4159 T4160 advmod least,subset
R2671 T4160 T4157 nsubj subset,correspond
R2672 T4161 T4160 det a,subset
R2673 T4162 T4160 prep of,subset
R2674 T4163 T4164 det the,DSBs
R2675 T4164 T4162 pobj DSBs,of
R2676 T4165 T4164 amod unrepaired,DSBs
R2677 T4166 T4157 prep to,correspond
R2678 T4167 T4166 pobj sites,to
R2679 T4168 T4167 prep of,sites
R2680 T4169 T4170 amod defective,repair
R2681 T4170 T4168 pobj repair,of
R2682 T4171 T4172 npadvmod NCO,recombinational
R2683 T4172 T4170 amod recombinational,repair
R2684 T4173 T4147 punct .,suggests
R2685 T4175 T4176 aux To,assess
R2686 T4176 T4177 advcl assess,examined
R2687 T4178 T4179 mark whether,occurs
R2688 T4179 T4176 ccomp occurs,assess
R2689 T4180 T4181 compound CO,recombination
R2690 T4181 T4179 nsubj recombination,occurs
R2691 T4182 T4179 prep in,occurs
R2692 T4183 T4184 det the,mutant
R2693 T4184 T4182 pobj mutant,in
R2694 T4185 T4177 punct ", ",examined
R2695 T4186 T4177 nsubj we,examined
R2696 T4187 T4188 det the,distribution
R2697 T4188 T4177 dobj distribution,examined
R2698 T4189 T4188 prep of,distribution
R2699 T4190 T4191 det the,proteins
R2700 T4191 T4189 pobj proteins,of
R2701 T4192 T4193 compound mismatch,repair
R2702 T4193 T4191 compound repair,proteins
R2703 T4194 T4191 appos MLH1,proteins
R2704 T4195 T4194 cc and,MLH1
R2705 T4196 T4194 conj MLH3,MLH1
R2706 T4197 T4191 punct ", ",proteins
R2707 T4198 T4199 dep which,are
R2708 T4199 T4191 relcl are,proteins
R2709 T4200 T4199 advmod normally,are
R2710 T4201 T4199 acomp detectable,are
R2711 T4202 T4199 prep as,are
R2712 T4203 T4202 pobj foci,as
R2713 T4204 T4203 prep in,foci
R2714 T4205 T4206 amod mid,late
R2715 T4206 T4208 amod late,pachynema
R2716 T4207 T4206 punct -,late
R2717 T4208 T4204 pobj pachynema,in
R2718 T4209 T4199 cc and,are
R2719 T4210 T4199 conj mark,are
R2720 T4211 T4212 det the,locations
R2721 T4212 T4210 dobj locations,mark
R2722 T4213 T4212 prep of,locations
R2723 T4214 T4213 pobj chiasmata,of
R2724 T4215 T4216 punct [,31
R2725 T4216 T4177 parataxis 31,examined
R2726 T4217 T4216 nummod 30,31
R2727 T4218 T4216 punct ",",31
R2728 T4219 T4216 punct ],31
R2729 T4220 T4177 punct .,examined
R2730 T4222 T4223 advmod Remarkably,formed
R2731 T4223 T4230 ccomp formed,observed
R2732 T4224 T4223 punct ", ",formed
R2733 T4225 T4226 nmod MLH1,foci
R2734 T4226 T4223 nsubjpass foci,formed
R2735 T4227 T4225 punct /,MLH1
R2736 T4228 T4225 nummod 3,MLH1
R2737 T4229 T4223 auxpass were,formed
R2738 T4231 T4230 punct ;,observed
R2739 T4232 T4230 nsubj we,observed
R2740 T4233 T4234 quantmod 1,2
R2741 T4234 T4236 nummod 2,foci
R2742 T4235 T4234 punct –,2
R2743 T4236 T4230 dobj foci,observed
R2744 T4237 T4238 punct /,chromosome
R2745 T4238 T4236 prep chromosome,foci
R2746 T4239 T4230 prep as,observed
R2747 T4240 T4239 prep in,as
R2748 T4241 T4242 amod wild,type
R2749 T4242 T4240 pobj type,in
R2750 T4243 T4239 cc and,as
R2751 T4244 T4239 conj at,as
R2752 T4245 T4246 amod typical,levels
R2753 T4246 T4244 pobj levels,at
R2754 T4247 T4246 amod overall,levels
R2755 T4248 T4249 punct (,10
R2756 T4249 T4246 parataxis 10,levels
R2757 T4250 T4251 nsubj MLH3,2
R2758 T4251 T4249 ccomp 2,10
R2759 T4252 T4251 punct =,2
R2760 T4253 T4251 quantmod 23,2
R2761 T4254 T4251 punct ±,2
R2762 T4255 T4249 punct ", ",10
R2763 T4256 T4249 nsubj N,10
R2764 T4257 T4249 punct =,10
R2765 T4258 T4249 punct ;,10
R2766 T4259 T4260 punct [,32
R2767 T4260 T4249 parataxis 32,10
R2768 T4261 T4260 nummod 30,32
R2769 T4262 T4260 punct ",",32
R2770 T4263 T4260 punct ],32
R2771 T4264 T4249 punct ),10
R2772 T4265 T4230 prep on,observed
R2773 T4266 T4267 amod mid,late
R2774 T4267 T4269 nmod late,pachytene
R2775 T4268 T4267 punct -,late
R2776 T4269 T4270 compound pachytene,chromosomes
R2777 T4270 T4265 pobj chromosomes,on
R2778 T4271 T4272 punct (,4M
R2779 T4272 T4230 parataxis 4M,observed
R2780 T4273 T4272 compound Figure,4M
R2781 T4274 T4272 cc and,4M
R2782 T4275 T4272 conj 4N,4M
R2783 T4276 T4272 punct ;,4M
R2784 T4277 T4278 nsubj MLH1,shown
R2785 T4278 T4272 ccomp shown,4M
R2786 T4279 T4278 neg not,shown
R2787 T4280 T4272 punct ),4M
R2788 T4281 T4230 punct .,observed
R2789 T4283 T4284 mark Since,had
R2790 T4284 T4294 advcl had,was
R2791 T4285 T4286 punct <,1
R2792 T4286 T4287 nummod 1,%
R2793 T4287 T4284 nsubj %,had
R2794 T4288 T4287 prep of,%
R2795 T4289 T4290 compound Trip13Gt,Gt
R2796 T4290 T4292 compound Gt,pachytene
R2797 T4291 T4290 punct /,Gt
R2798 T4292 T4293 compound pachytene,nuclei
R2799 T4293 T4288 pobj nuclei,of
R2800 T4295 T4296 amod normal,repair
R2801 T4296 T4284 dobj repair,had
R2802 T4297 T4298 punct (,see
R2803 T4298 T4284 parataxis see,had
R2804 T4299 T4300 mark as,judged
R2805 T4300 T4298 advcl judged,see
R2806 T4301 T4300 prep by,judged
R2807 T4302 T4301 pobj absence,by
R2808 T4303 T4302 prep of,absence
R2809 T4304 T4305 amod persistent,markers
R2810 T4305 T4303 pobj markers,of
R2811 T4306 T4307 compound DSB,repair
R2812 T4307 T4305 compound repair,markers
R2813 T4308 T4298 punct ;,see
R2814 T4309 T4298 dobj above,see
R2815 T4310 T4298 punct ),see
R2816 T4311 T4284 punct ", ",had
R2817 T4312 T4284 cc but,had
R2818 T4313 T4314 nsubj most,had
R2819 T4314 T4284 conj had,had
R2820 T4315 T4313 prep of,most
R2821 T4316 T4317 det the,nuclei
R2822 T4317 T4315 pobj nuclei,of
R2823 T4318 T4317 compound pachytene,nuclei
R2824 T4319 T4320 nmod MLH1,foci
R2825 T4320 T4314 dobj foci,had
R2826 T4321 T4319 punct /,MLH1
R2827 T4322 T4319 nummod 3,MLH1
R2828 T4323 T4294 punct ", ",was
R2829 T4324 T4294 nsubj it,was
R2830 T4325 T4294 acomp unlikely,was
R2831 T4326 T4327 mark that,formed
R2832 T4327 T4294 ccomp formed,was
R2833 T4328 T4329 det the,foci
R2834 T4329 T4327 nsubj foci,formed
R2835 T4330 T4329 nmod MLH1,foci
R2836 T4331 T4330 punct /,MLH1
R2837 T4332 T4330 nummod 3,MLH1
R2838 T4333 T4334 advmod only,on
R2839 T4334 T4327 prep on,formed
R2840 T4335 T4334 pobj chromosomes,on
R2841 T4336 T4335 prep with,chromosomes
R2842 T4337 T4338 advmod fully,repaired
R2843 T4338 T4339 amod repaired,DSBs
R2844 T4339 T4336 pobj DSBs,with
R2845 T4340 T4294 punct .,was
R2846 T4342 T4343 aux To,test
R2847 T4343 T4344 advcl test,conducted
R2848 T4345 T4343 dobj this,test
R2849 T4346 T4343 advmod directly,test
R2850 T4347 T4344 punct ", ",conducted
R2851 T4348 T4344 nsubj we,conducted
R2852 T4349 T4350 amod double,staining
R2853 T4350 T4344 dobj staining,conducted
R2854 T4351 T4344 prep for,conducted
R2855 T4352 T4351 pobj MLH1,for
R2856 T4353 T4352 cc and,MLH1
R2857 T4354 T4355 compound RAD51,DMC1
R2858 T4355 T4352 conj DMC1,MLH1
R2859 T4356 T4355 punct /,DMC1
R2860 T4357 T4344 punct .,conducted
R2861 T4359 T4360 compound MLH1,foci
R2862 T4360 T4361 nsubj foci,were
R2863 T4362 T4361 acomp present,were
R2864 T4363 T4361 prep on,were
R2865 T4364 T4363 pobj chromosomes,on
R2866 T4365 T4366 dep that,contained
R2867 T4366 T4364 relcl contained,chromosomes
R2868 T4367 T4366 advmod also,contained
R2869 T4368 T4369 amod numerous,foci
R2870 T4369 T4366 dobj foci,contained
R2871 T4370 T4371 compound RAD51,DMC1
R2872 T4371 T4369 compound DMC1,foci
R2873 T4372 T4371 punct /,DMC1
R2874 T4373 T4374 punct (,4O
R2875 T4374 T4366 parataxis 4O,contained
R2876 T4375 T4374 compound Figure,4O
R2877 T4376 T4374 cc and,4O
R2878 T4377 T4374 conj 4P,4O
R2879 T4378 T4374 punct ),4O
R2880 T4379 T4361 punct .,were
R2881 T4381 T4382 aux To,assess
R2882 T4382 T4383 advcl assess,treated
R2883 T4384 T4385 mark whether,represent
R2884 T4385 T4382 ccomp represent,assess
R2885 T4386 T4387 det these,foci
R2886 T4387 T4385 nsubj foci,represent
R2887 T4388 T4387 nmod MLH1,foci
R2888 T4389 T4388 punct /,MLH1
R2889 T4390 T4388 nummod 3,MLH1
R2890 T4391 T4387 prep in,foci
R2891 T4392 T4393 compound Trip13Gt,Gt
R2892 T4393 T4395 compound Gt,pachytene
R2893 T4394 T4393 punct /,Gt
R2894 T4395 T4396 compound pachytene,spermatocytes
R2895 T4396 T4391 pobj spermatocytes,in
R2896 T4397 T4398 compound CO,events
R2897 T4398 T4385 dobj events,represent
R2898 T4399 T4398 acl completed,events
R2899 T4400 T4399 prep to,completed
R2900 T4401 T4402 det a,point
R2901 T4402 T4400 pobj point,to
R2902 T4403 T4404 advmod where,maintain
R2903 T4404 T4402 relcl maintain,point
R2904 T4405 T4404 nsubj they,maintain
R2905 T4406 T4404 aux could,maintain
R2906 T4407 T4408 amod interhomolog,attachments
R2907 T4408 T4404 dobj attachments,maintain
R2908 T4409 T4404 prep though,maintain
R2909 T4410 T4411 det the,end
R2910 T4411 T4409 pobj end,though
R2911 T4412 T4411 prep of,end
R2912 T4413 T4412 pobj prophase,of
R2913 T4414 T4413 nummod I,prophase
R2914 T4415 T4383 punct ", ",treated
R2915 T4416 T4383 nsubj we,treated
R2916 T4417 T4418 amod testicular,cells
R2917 T4418 T4383 dobj cells,treated
R2918 T4419 T4418 prep from,cells
R2919 T4420 T4421 quantmod 17.5,20.5
R2920 T4421 T4423 nummod 20.5,d
R2921 T4422 T4421 punct –,20.5
R2922 T4423 T4425 npadvmod d,old
R2923 T4424 T4423 punct -,d
R2924 T4425 T4427 amod old,mice
R2925 T4426 T4425 punct -,old
R2926 T4427 T4419 pobj mice,from
R2927 T4428 T4427 nmod control,mice
R2928 T4429 T4428 punct (,control
R2929 T4430 T4431 punct +,+
R2930 T4431 T4428 appos +,control
R2931 T4432 T4431 punct /,+
R2932 T4433 T4428 punct ),control
R2933 T4434 T4428 punct ", ",control
R2934 T4435 T4436 compound Trip13Gt,Gt
R2935 T4436 T4428 conj Gt,control
R2936 T4437 T4436 punct /,Gt
R2937 T4438 T4436 punct ", ",Gt
R2938 T4439 T4436 cc and,Gt
R2939 T4440 T4436 conj Dmc1,Gt
R2940 T4441 T4440 punct −,Dmc1
R2941 T4442 T4440 punct /,Dmc1
R2942 T4443 T4440 punct −,Dmc1
R2943 T4444 T4383 prep with,treated
R2944 T4445 T4446 det the,inhibitor
R2945 T4446 T4444 pobj inhibitor,with
R2946 T4447 T4448 compound protein,phosphatase
R2947 T4448 T4446 compound phosphatase,inhibitor
R2948 T4449 T4450 amod okadaic,acid
R2949 T4450 T4446 appos acid,inhibitor
R2950 T4451 T4446 punct (,inhibitor
R2951 T4452 T4446 appos OA,inhibitor
R2952 T4453 T4446 punct ),inhibitor
R2953 T4454 T4446 punct ", ",inhibitor
R2954 T4455 T4456 det a,chemical
R2955 T4456 T4446 appos chemical,inhibitor
R2956 T4457 T4458 dep that,induces
R2957 T4458 T4456 relcl induces,chemical
R2958 T4459 T4458 dobj degradation,induces
R2959 T4460 T4459 prep of,degradation
R2960 T4461 T4462 det the,SC
R2961 T4462 T4460 pobj SC,of
R2962 T4463 T4459 punct ", ",degradation
R2963 T4464 T4465 compound chromosome,condensation
R2964 T4465 T4459 conj condensation,degradation
R2965 T4466 T4465 punct ", ",condensation
R2966 T4467 T4465 cc and,condensation
R2967 T4468 T4469 amod premature,progression
R2968 T4469 T4465 conj progression,condensation
R2969 T4470 T4469 prep to,progression
R2970 T4471 T4470 pobj metaphase,to
R2971 T4472 T4471 nummod I,metaphase
R2972 T4473 T4474 punct [,33
R2973 T4474 T4383 parataxis 33,treated
R2974 T4475 T4474 punct ],33
R2975 T4476 T4383 punct .,treated
R2976 T4478 T4479 nummod Fifteen,spreads
R2977 T4479 T4481 nsubjpass spreads,identified
R2978 T4480 T4479 compound metaphase,spreads
R2979 T4482 T4481 auxpass were,identified
R2980 T4483 T4481 prep for,identified
R2981 T4484 T4485 det each,genotype
R2982 T4485 T4483 pobj genotype,for
R2983 T4486 T4481 punct .,identified
R2984 T4488 T4489 mark Whereas,had
R2985 T4489 T4498 advcl had,had
R2986 T4490 T4489 nsubj all,had
R2987 T4491 T4490 prep of,all
R2988 T4492 T4493 det the,spreads
R2989 T4493 T4491 pobj spreads,of
R2990 T4494 T4493 nmod Dmc1,spreads
R2991 T4495 T4494 punct −,Dmc1
R2992 T4496 T4494 punct /,Dmc1
R2993 T4497 T4494 punct −,Dmc1
R2994 T4499 T4500 punct ∼,35
R2995 T4500 T4501 nummod 35,chromosomes
R2996 T4501 T4489 dobj chromosomes,had
R2997 T4502 T4500 cc or,35
R2998 T4503 T4500 conj more,35
R2999 T4504 T4501 amod condensed,chromosomes
R3000 T4505 T4498 punct ", ",had
R3001 T4506 T4498 nsubj all,had
R3002 T4507 T4506 prep of,all
R3003 T4508 T4509 det the,spreads
R3004 T4509 T4507 pobj spreads,of
R3005 T4510 T4511 punct +,+
R3006 T4511 T4509 punct +,spreads
R3007 T4512 T4511 punct /,+
R3008 T4513 T4511 cc and,+
R3009 T4514 T4515 compound Trip13Gt,Gt
R3010 T4515 T4511 conj Gt,+
R3011 T4516 T4515 punct /,Gt
R3012 T4517 T4518 quantmod 20,25
R3013 T4518 T4498 dobj 25,had
R3014 T4519 T4518 punct –,25
R3015 T4520 T4498 punct ", ",had
R3016 T4521 T4498 advcl suggesting,had
R3017 T4522 T4523 mark that,represent
R3018 T4523 T4521 ccomp represent,suggesting
R3019 T4524 T4525 det the,foci
R3020 T4525 T4523 nsubj foci,represent
R3021 T4526 T4525 nmod MLH1,foci
R3022 T4527 T4526 punct /,MLH1
R3023 T4528 T4526 nummod 3,MLH1
R3024 T4529 T4525 prep in,foci
R3025 T4530 T4531 compound Trip13Gt,Gt
R3026 T4531 T4533 compound Gt,pachytene
R3027 T4532 T4531 punct /,Gt
R3028 T4533 T4534 compound pachytene,spermatocytes
R3029 T4534 T4529 pobj spermatocytes,in
R3030 T4535 T4523 dobj sites,represent
R3031 T4536 T4535 prep of,sites
R3032 T4537 T4538 amod completed,COs
R3033 T4538 T4536 pobj COs,of
R3034 T4539 T4537 punct ", ",completed
R3035 T4540 T4537 cc or,completed
R3036 T4541 T4542 advmod near,completed
R3037 T4542 T4537 conj completed,completed
R3038 T4543 T4542 punct -,completed
R3039 T4544 T4538 punct ", ",COs
R3040 T4545 T4498 punct .,had
R3041 T4547 T4548 mark Because,made
R3042 T4548 T4552 advcl made,is
R3043 T4549 T4550 det the,preparations
R3044 T4550 T4548 nsubjpass preparations,made
R3045 T4551 T4548 auxpass were,made
R3046 T4553 T4548 prep from,made
R3047 T4554 T4555 amod whole,testes
R3048 T4555 T4553 pobj testes,from
R3049 T4556 T4552 punct ", ",is
R3050 T4557 T4552 nsubj it,is
R3051 T4558 T4552 acomp possible,is
R3052 T4559 T4560 mark that,were
R3053 T4560 T4552 ccomp were,is
R3054 T4561 T4562 det the,metaphases
R3055 T4562 T4560 nsubj metaphases,were
R3056 T4563 T4564 npadvmod univalent,containing
R3057 T4564 T4562 amod containing,metaphases
R3058 T4565 T4564 punct -,containing
R3059 T4566 T4562 prep from,metaphases
R3060 T4567 T4568 nmod Dmc1,mice
R3061 T4568 T4566 pobj mice,from
R3062 T4569 T4567 punct −,Dmc1
R3063 T4570 T4567 punct /,Dmc1
R3064 T4571 T4567 punct −,Dmc1
R3065 T4572 T4560 prep from,were
R3066 T4573 T4572 pobj spermatogonia,from
R3067 T4574 T4573 punct ", ",spermatogonia
R3068 T4575 T4573 cc not,spermatogonia
R3069 T4576 T4573 conj spermatocytes,spermatogonia
R3070 T4577 T4552 punct .,is
R3071 T4919 T4920 compound TRIP13,Deficiency
R3072 T4920 T4921 nsubj Deficiency,Alleviate
R3073 T4922 T4921 aux Does,Alleviate
R3074 T4923 T4921 neg Not,Alleviate
R3075 T4924 T4925 amod Meiotic,Arrest
R3076 T4925 T4926 compound Arrest,Phenotypes
R3077 T4926 T4921 dobj Phenotypes,Alleviate
R3078 T4927 T4926 prep of,Phenotypes
R3079 T4928 T4927 pobj Mutants,of
R3080 T4929 T4928 amod Defective,Mutants
R3081 T4930 T4929 prep in,Defective
R3082 T4931 T4930 pobj Synapsis,in
R3083 T4933 T4934 aux To,determine
R3084 T4934 T4935 advcl determine,analyzed
R3085 T4936 T4937 mark if,prevents
R3086 T4937 T4934 ccomp prevents,determine
R3087 T4938 T4939 compound TRIP13,deficiency
R3088 T4939 T4937 nsubj deficiency,prevents
R3089 T4940 T4937 dobj apoptosis,prevents
R3090 T4941 T4940 acl triggered,apoptosis
R3091 T4942 T4941 agent by,triggered
R3092 T4943 T4942 pobj asynapsis,by
R3093 T4944 T4941 prep as,triggered
R3094 T4945 T4944 prep in,as
R3095 T4946 T4947 compound C.,elegans
R3096 T4947 T4945 pobj elegans,in
R3097 T4948 T4935 punct ", ",analyzed
R3098 T4949 T4935 nsubj we,analyzed
R3099 T4950 T4935 dobj mice,analyzed
R3100 T4951 T4952 dep that,were
R3101 T4952 T4950 relcl were,mice
R3102 T4953 T4954 advmod doubly,mutant
R3103 T4954 T4952 acomp mutant,were
R3104 T4955 T4954 prep for,mutant
R3105 T4956 T4955 pobj Spo11,for
R3106 T4957 T4956 cc and,Spo11
R3107 T4958 T4956 conj Trip13,Spo11
R3108 T4959 T4935 punct .,analyzed
R3109 T4961 T4962 nsubj SPO11,is
R3110 T4963 T4964 det a,transesterase
R3111 T4964 T4962 attr transesterase,is
R3112 T4965 T4966 dep that,is
R3113 T4966 T4964 relcl is,transesterase
R3114 T4967 T4966 acomp essential,is
R3115 T4968 T4967 prep for,essential
R3116 T4969 T4970 det the,creation
R3117 T4970 T4968 pobj creation,for
R3118 T4971 T4970 prep of,creation
R3119 T4972 T4973 advmod genetically,programmed
R3120 T4973 T4974 amod programmed,DSB
R3121 T4974 T4971 pobj DSB,of
R3122 T4975 T4970 prep during,creation
R3123 T4976 T4975 pobj leptonema,during
R3124 T4977 T4976 prep of,leptonema
R3125 T4978 T4979 amod many,organisms
R3126 T4979 T4977 pobj organisms,of
R3127 T4980 T4979 punct ", ",organisms
R3128 T4981 T4979 prep including,organisms
R3129 T4982 T4981 pobj mice,including
R3130 T4983 T4984 punct [,18
R3131 T4984 T4966 parataxis 18,is
R3132 T4985 T4984 punct ],18
R3133 T4986 T4962 punct .,is
R3134 T4988 T4989 prep In,have
R3135 T4990 T4991 compound C.,elegans
R3136 T4991 T4988 pobj elegans,In
R3137 T4992 T4989 punct ", ",have
R3138 T4993 T4994 nmod spo,gametes
R3139 T4994 T4989 nsubj gametes,have
R3140 T4995 T4993 punct -,spo
R3141 T4996 T4993 nummod 11,spo
R3142 T4997 T4994 compound mutant,gametes
R3143 T4998 T4999 amod extensive,asynapsis
R3144 T4999 T4989 dobj asynapsis,have
R3145 T5000 T4999 punct ", ",asynapsis
R3146 T5001 T5002 dep which,triggers
R3147 T5002 T4999 relcl triggers,asynapsis
R3148 T5003 T5004 npadvmod PCH,dependent
R3149 T5004 T5007 amod dependent,apoptosis
R3150 T5005 T5003 punct -,PCH
R3151 T5006 T5003 nummod 2,PCH
R3152 T5007 T5002 dobj apoptosis,triggers
R3153 T5008 T5007 prep in,apoptosis
R3154 T5009 T5008 pobj pachynema,in
R3155 T5010 T5011 punct [,2
R3156 T5011 T4989 parataxis 2,have
R3157 T5012 T5011 punct ],2
R3158 T5013 T4989 punct .,have
R3159 T5015 T5016 prep In,are
R3160 T5017 T5015 pobj mice,In
R3161 T5018 T5016 punct ", ",are
R3162 T5019 T5020 nmod Spo11,spermatocytes
R3163 T5020 T5016 nsubj spermatocytes,are
R3164 T5021 T5019 punct −,Spo11
R3165 T5022 T5019 punct /,Spo11
R3166 T5023 T5019 punct −,Spo11
R3167 T5024 T5025 advmod severely,defective
R3168 T5025 T5016 acomp defective,are
R3169 T5026 T5016 prep in,are
R3170 T5027 T5028 amod homologous,synapsis
R3171 T5028 T5026 pobj synapsis,in
R3172 T5029 T5028 compound chromosome,synapsis
R3173 T5030 T5031 punct [,35
R3174 T5031 T5016 parataxis 35,are
R3175 T5032 T5031 nummod 34,35
R3176 T5033 T5031 punct ",",35
R3177 T5034 T5031 punct ],35
R3178 T5035 T5016 punct ", ",are
R3179 T5036 T5016 cc and,are
R3180 T5037 T5016 conj arrest,are
R3181 T5038 T5037 prep with,arrest
R3182 T5039 T5038 pobj chromosomes,with
R3183 T5040 T5037 prep in,arrest
R3184 T5041 T5042 det a,state
R3185 T5042 T5040 pobj state,in
R3186 T5043 T5042 amod characteristic,state
R3187 T5044 T5043 prep of,characteristic
R3188 T5045 T5046 det the,transition
R3189 T5046 T5044 pobj transition,of
R3190 T5047 T5048 compound zygotene,pachytene
R3191 T5048 T5046 compound pachytene,transition
R3192 T5049 T5048 punct /,pachytene
R3193 T5050 T5051 punct (,3H
R3194 T5051 T5037 parataxis 3H,arrest
R3195 T5052 T5051 compound Figure,3H
R3196 T5053 T5051 punct ),3H
R3197 T5054 T5016 punct .,are
R3198 T5056 T5057 nsubj Spermatocytes,progressed
R3199 T5058 T5056 prep in,Spermatocytes
R3200 T5059 T5060 nmod Trip13Gt,Gt
R3201 T5060 T5062 nmod Gt,testes
R3202 T5061 T5060 punct /,Gt
R3203 T5062 T5058 pobj testes,in
R3204 T5063 T5062 nmod Spo11,testes
R3205 T5064 T5063 punct −,Spo11
R3206 T5065 T5063 punct /,Spo11
R3207 T5066 T5063 punct −,Spo11
R3208 T5067 T5057 advmod maximally,progressed
R3209 T5068 T5057 prep to,progressed
R3210 T5069 T5070 det that,point
R3211 T5070 T5068 pobj point,to
R3212 T5071 T5057 prep before,progressed
R3213 T5072 T5071 pcomp undergoing,before
R3214 T5073 T5072 dobj death,undergoing
R3215 T5074 T5075 punct (,3I
R3216 T5075 T5072 parataxis 3I,undergoing
R3217 T5076 T5075 compound Figs,3I
R3218 T5077 T5075 punct ),3I
R3219 T5078 T5072 punct ", ",undergoing
R3220 T5079 T5080 advmod well,before
R3221 T5080 T5072 prep before,undergoing
R3222 T5081 T5082 det the,checkpoint
R3223 T5082 T5080 pobj checkpoint,before
R3224 T5083 T5082 compound spindle,checkpoint
R3225 T5084 T5085 dep that,eliminates
R3226 T5085 T5082 relcl eliminates,checkpoint
R3227 T5086 T5087 compound achiasmate,spermatocytes
R3228 T5087 T5085 dobj spermatocytes,eliminates
R3229 T5088 T5089 punct [,36
R3230 T5089 T5057 parataxis 36,progressed
R3231 T5090 T5089 punct ],36
R3232 T5091 T5057 punct .,progressed
R3233 T5093 T5094 expl There,was
R3234 T5095 T5096 det no,evidence
R3235 T5096 T5094 attr evidence,was
R3236 T5097 T5096 prep of,evidence
R3237 T5098 T5099 nmod metaphase,spermatocytes
R3238 T5099 T5097 pobj spermatocytes,of
R3239 T5100 T5098 nummod I,metaphase
R3240 T5101 T5099 cc or,spermatocytes
R3241 T5102 T5103 amod postmeiotic,spermatids
R3242 T5103 T5099 conj spermatids,spermatocytes
R3243 T5104 T5096 prep in,evidence
R3244 T5105 T5106 det these,testes
R3245 T5106 T5104 pobj testes,in
R3246 T5107 T5094 punct ", ",was
R3247 T5108 T5094 prep unlike,was
R3248 T5109 T5108 pobj those,unlike
R3249 T5110 T5109 acl seen,those
R3250 T5111 T5110 prep in,seen
R3251 T5112 T5113 nmod Trip13,mutants
R3252 T5113 T5111 pobj mutants,in
R3253 T5114 T5113 amod single,mutants
R3254 T5115 T5116 punct (,3G
R3255 T5116 T5094 parataxis 3G,was
R3256 T5117 T5116 compound Figure,3G
R3257 T5118 T5116 punct ),3G
R3258 T5119 T5094 punct .,was
R3259 T5121 T5122 prep In,disrupted
R3260 T5123 T5121 pobj contrast,In
R3261 T5124 T5123 prep to,contrast
R3262 T5125 T5126 det the,synapsis
R3263 T5126 T5124 pobj synapsis,to
R3264 T5127 T5126 amod complete,synapsis
R3265 T5128 T5126 prep in,synapsis
R3266 T5129 T5130 compound Trip13Gt,Gt
R3267 T5130 T5132 compound Gt,pachytene
R3268 T5131 T5130 punct /,Gt
R3269 T5132 T5133 compound pachytene,spermatocytes
R3270 T5133 T5128 pobj spermatocytes,in
R3271 T5134 T5135 punct (,5A
R3272 T5135 T5126 parataxis 5A,synapsis
R3273 T5136 T5135 compound Figure,5A
R3274 T5137 T5135 punct ),5A
R3275 T5138 T5126 punct ", ",synapsis
R3276 T5139 T5140 prep in,is
R3277 T5140 T5126 relcl is,synapsis
R3278 T5141 T5139 pobj which,in
R3279 T5142 T5140 nsubj SPO11,is
R3280 T5143 T5140 acomp available,is
R3281 T5144 T5140 prep in,is
R3282 T5145 T5144 pobj leptonema,in
R3283 T5146 T5147 aux to,initiate
R3284 T5147 T5140 advcl initiate,is
R3285 T5148 T5149 punct (,S2A
R3286 T5149 T5147 parataxis S2A,initiate
R3287 T5150 T5149 prep via,S2A
R3288 T5151 T5152 compound DSB,induction
R3289 T5152 T5150 pobj induction,via
R3290 T5153 T5149 punct ", ",S2A
R3291 T5154 T5149 compound Figure,S2A
R3292 T5155 T5149 cc and,S2A
R3293 T5156 T5149 conj S2B,S2A
R3294 T5157 T5149 punct ),S2A
R3295 T5158 T5159 det a,search
R3296 T5159 T5147 dobj search,initiate
R3297 T5160 T5161 npadvmod recombination,driven
R3298 T5161 T5159 amod driven,search
R3299 T5162 T5161 punct -,driven
R3300 T5163 T5159 compound homolog,search
R3301 T5164 T5122 punct ", ",disrupted
R3302 T5165 T5166 compound chromosome,synapsis
R3303 T5166 T5122 nsubjpass synapsis,disrupted
R3304 T5167 T5166 prep in,synapsis
R3305 T5168 T5169 advmod doubly,mutant
R3306 T5169 T5170 amod mutant,spermatocytes
R3307 T5170 T5167 pobj spermatocytes,in
R3308 T5171 T5122 auxpass was,disrupted
R3309 T5172 T5122 advmod highly,disrupted
R3310 T5173 T5122 prep as,disrupted
R3311 T5174 T5173 prep in,as
R3312 T5175 T5176 nmod Spo11,mutants
R3313 T5176 T5174 pobj mutants,in
R3314 T5177 T5176 amod single,mutants
R3315 T5178 T5179 punct (,5B
R3317 T5180 T5179 compound Figure,5B
R3346 T5211 T5210 punct ],37
R3347 T5212 T5188 punct ", ",performed
R3348 T5213 T5188 prep with,performed
R3349 T5214 T5215 amod similar,results
R3350 T5215 T5213 pobj results,with
R3351 T5216 T5217 punct (,3J
R3352 T5217 T5188 parataxis 3J,performed
R3353 T5218 T5217 compound Figure,3J
R3354 T5219 T5217 cc and,3J
R3355 T5220 T5217 conj 3K,3J
R3356 T5221 T5217 punct ;,3J
R3357 T5222 T5223 nsubj immunocytology,shown
R3358 T5223 T5217 ccomp shown,3J
R3359 T5224 T5223 neg not,shown
R3360 T5225 T5217 punct ),3J
R3361 T5226 T5188 punct .,performed
R3362 T5229 T5230 amod In,y
R3363 T5232 T5233 compound e,a
R3364 T5233 T5234 compound a,s
R3365 T5238 T5239 amod d,e
R3384 T5265 T5266 compound mouse,SYCP1
R3385 T5266 T5264 nsubj SYCP1,be
R3386 T5267 T5264 aux might,be
R3387 T5269 T5270 det a,equivalent
R3388 T5270 T5264 attr equivalent,be
R3389 T5271 T5270 amod functional,equivalent
R3390 T5272 T5270 prep of,equivalent
R3391 T5273 T5272 pobj Zip1p,of
R3392 T5274 T5268 punct ", ",be
R3393 T5275 T5276 mark because,arrest
R3394 T5276 T5268 advcl arrest,be
R3395 T5277 T5278 compound Sycp1,spermatocytes
R3396 T5278 T5276 nsubj spermatocytes,arrest
R3397 T5279 T5278 compound mutant,spermatocytes
R3398 T5280 T5276 prep at,arrest
R3399 T5281 T5282 advmod approximately,point
R3400 T5282 T5280 pobj point,at
R3401 T5283 T5282 det the,point
R3402 T5284 T5282 amod same,point
R3403 T5285 T5282 prep as,point
R3404 T5286 T5287 compound Trip13,mutants
R3405 T5287 T5285 pobj mutants,as
R3406 T5288 T5268 punct ", ",be
R3407 T5289 T5268 expl there,be
R3408 T5290 T5268 aux would,be
R3409 T5291 T5292 det no,opportunity
R3410 T5292 T5268 attr opportunity,be
R3411 T5293 T5294 aux to,observe
R3412 T5294 T5292 acl observe,opportunity
R3413 T5295 T5294 dobj bypass,observe
R3414 T5296 T5295 prep of,bypass
R3415 T5297 T5296 pobj Sycp1,of
R3416 T5298 T5297 punct −,Sycp1
R3417 T5299 T5297 punct /,Sycp1
R3418 T5300 T5297 punct −,Sycp1
R3419 T5301 T5268 punct .,be
R3420 T5303 T5304 mark Since,is
R3421 T5304 T5306 advcl is,suggested
R3422 T5305 T5304 nsubj Zip2p,is
R3423 T5307 T5304 acomp present,is
R3424 T5308 T5304 prep at,is
R3425 T5309 T5308 pobj sites,at
R3426 T5310 T5309 prep of,sites
R3427 T5311 T5312 amod axial,associations
R3428 T5312 T5310 pobj associations,of
R3429 T5313 T5308 punct ", ",at
R3430 T5314 T5315 advmod even,in
R3431 T5315 T5308 prep in,at
R3432 T5316 T5317 compound zip1,mutants
R3433 T5317 T5315 pobj mutants,in
R3434 T5318 T5306 punct ", ",suggested
R3435 T5319 T5306 nsubjpass it,suggested
R3436 T5320 T5306 aux has,suggested
R3437 T5321 T5306 auxpass been,suggested
R3438 T5322 T5323 mark that,promotes
R3439 T5323 T5306 ccomp promotes,suggested
R3440 T5324 T5323 nsubj Zip2p,promotes
R3441 T5325 T5323 dobj initiation,promotes
R3442 T5326 T5325 prep of,initiation
R3443 T5327 T5328 compound chromosome,synapsis
R3444 T5328 T5326 pobj synapsis,of
R3445 T5329 T5330 punct [,38
R3446 T5330 T5306 parataxis 38,suggested
R3447 T5331 T5330 punct ],38
R3448 T5332 T5306 punct .,suggested
R3449 T5334 T5335 det These,observations
R3450 T5335 T5336 nsubj observations,raise
R3451 T5337 T5338 det the,possibility
R3452 T5338 T5336 dobj possibility,raise
R3453 T5339 T5340 mark that,responds
R3454 T5340 T5338 acl responds,possibility
R3455 T5341 T5340 prep in,responds
R3456 T5342 T5341 pobj yeast,in
R3457 T5343 T5340 punct ", ",responds
R3458 T5344 T5340 nsubj Pch2p,responds
R3459 T5345 T5340 prep to,responds
R3460 T5346 T5347 compound synapsis,polymerization
R3461 T5347 T5345 pobj polymerization,to
R3462 T5348 T5349 advmod rather,than
R3463 T5349 T5347 cc than,polymerization
R3464 T5350 T5347 conj initiation,polymerization
R3465 T5351 T5336 punct .,raise
R3466 T5353 T5354 aux To,test
R3467 T5354 T5355 advcl test,performed
R3468 T5356 T5354 dobj this,test
R3469 T5357 T5355 punct ", ",performed
R3470 T5358 T5355 nsubj we,performed
R3471 T5359 T5360 compound epistasis,analysis
R3472 T5360 T5355 dobj analysis,performed
R3473 T5361 T5355 prep with,performed
R3474 T5362 T5363 det a,allele
R3475 T5363 T5361 pobj allele,with
R3476 T5364 T5363 compound Rec8,allele
R3477 T5365 T5363 punct (,allele
R3478 T5366 T5363 appos Rec8Mei8,allele
R3479 T5367 T5366 punct ", ",Rec8Mei8
R3480 T5368 T5366 acl abbreviated,Rec8Mei8
R3481 T5369 T5368 prep as,abbreviated
R3482 T5370 T5369 pobj Rec8,as
R3483 T5371 T5370 punct −,Rec8
R3484 T5372 T5355 punct ),performed
R3485 T5373 T5355 punct .,performed
R3486 T5375 T5376 amod Meiotic,chromosomes
R3487 T5376 T5377 nsubj chromosomes,undergo
R3488 T5378 T5376 prep of,chromosomes
R3489 T5379 T5380 compound Rec8,spermatocytes
R3490 T5380 T5378 pobj spermatocytes,of
R3491 T5381 T5380 compound mutant,spermatocytes
R3492 T5382 T5383 amod apparent,pairing
R3493 T5383 T5377 dobj pairing,undergo
R3494 T5384 T5383 compound homolog,pairing
R3495 T5385 T5383 cc and,pairing
R3496 T5386 T5387 amod interhomolog,initiation
R3497 T5387 T5383 conj initiation,pairing
R3498 T5388 T5387 amod synaptic,initiation
R3499 T5389 T5377 punct ", ",undergo
R3500 T5390 T5377 cc but,undergo
R3501 T5391 T5377 conj are,undergo
R3502 T5392 T5391 acomp defective,are
R3503 T5393 T5392 prep in,defective
R3504 T5394 T5395 compound DSB,repair
R3505 T5395 T5393 pobj repair,in
R3506 T5396 T5391 cc and,are
R3507 T5397 T5391 conj fail,are
R3508 T5398 T5399 aux to,maintain
R3509 T5399 T5397 xcomp maintain,fail
R3510 T5400 T5399 amod interhomolog,maintain
R3511 T5401 T5399 dep synapsis,maintain
R3512 T5402 T5403 punct [,40
R3513 T5403 T5391 parataxis 40,are
R3514 T5404 T5403 nummod 39,40
R3515 T5405 T5403 punct ",",40
R3516 T5406 T5403 punct ],40
R3517 T5407 T5377 punct .,undergo
R3518 T5409 T5410 advmod Rather,appear
R3519 T5411 T5410 punct ", ",appear
R3520 T5412 T5413 compound sister,chromatids
R3521 T5413 T5410 nsubj chromatids,appear
R3522 T5414 T5415 aux to,synapse
R3523 T5415 T5410 xcomp synapse,appear
R3524 T5416 T5410 cc and,appear
R3525 T5417 T5418 auxpass are,bound
R3526 T5418 T5410 conj bound,appear
R3527 T5419 T5418 prep by,bound
R3528 T5420 T5419 pobj SYCP1,by
R3529 T5421 T5418 prep along,bound
R3530 T5422 T5423 poss their,axes
R3531 T5423 T5421 pobj axes,along
R3532 T5424 T5410 punct .,appear
R3533 T5426 T5427 compound Rec8,mutants
R3534 T5427 T5428 nsubj mutants,progress
R3535 T5429 T5428 aux do,progress
R3536 T5430 T5428 neg not,progress
R3537 T5431 T5428 prep to,progress
R3538 T5432 T5431 pobj diplonema,to
R3539 T5433 T5432 cc or,diplonema
R3540 T5434 T5432 conj metaphase,diplonema
R3541 T5435 T5434 nummod I,metaphase
R3542 T5436 T5428 punct .,progress
R3543 T5438 T5439 amod Double,analysis
R3544 T5439 T5441 nsubj analysis,indicated
R3545 T5440 T5439 compound mutant,analysis
R3546 T5442 T5443 mark that,is
R3547 T5443 T5441 ccomp is,indicated
R3548 T5444 T5443 nsubj Rec8,is
R3549 T5445 T5443 acomp epistatic,is
R3550 T5446 T5445 prep to,epistatic
R3551 T5447 T5446 pobj Trip13,to
R3552 T5448 T5441 punct .,indicated
R3553 T5450 T5451 prep As,resembled
R3554 T5452 T5450 prep in,As
R3555 T5453 T5454 det the,experiments
R3556 T5454 T5452 pobj experiments,in
R3557 T5455 T5454 nmod Spo11,experiments
R3558 T5456 T5455 cc and,Spo11
R3559 T5457 T5455 conj Mei1,Spo11
R3560 T5458 T5451 punct ", ",resembled
R3561 T5459 T5451 nsubj histology,resembled
R3562 T5460 T5459 prep of,histology
R3563 T5461 T5460 pobj testes,of
R3564 T5462 T5461 amod deficient,testes
R3565 T5463 T5462 prep for,deficient
R3566 T5464 T5465 preconj both,REC8
R3567 T5465 T5463 pobj REC8,for
R3568 T5466 T5465 cc and,REC8
R3569 T5467 T5465 conj TRIP13,REC8
R3570 T5468 T5469 det the,mutant
R3571 T5469 T5451 dobj mutant,resembled
R3572 T5470 T5469 compound Rec8,mutant
R3573 T5471 T5451 punct ", ",resembled
R3574 T5472 T5451 prep with,resembled
R3575 T5473 T5474 det no,evidence
R3576 T5474 T5472 pobj evidence,with
R3577 T5475 T5474 prep of,evidence
R3578 T5476 T5475 pobj progression,of
R3579 T5477 T5476 prep to,progression
R3580 T5478 T5477 pobj metaphase,to
R3581 T5479 T5478 nummod I,metaphase
R3582 T5480 T5481 dep that,occurs
R3583 T5481 T5476 relcl occurs,progression
R3584 T5482 T5481 prep in,occurs
R3585 T5483 T5484 compound Trip13Gt,Gt
R3586 T5484 T5486 compound Gt,mice
R3587 T5485 T5484 punct /,Gt
R3588 T5486 T5482 pobj mice,in
R3589 T5487 T5488 punct (,3L
R3590 T5488 T5451 parataxis 3L,resembled
R3591 T5489 T5488 compound Figure,3L
R3592 T5490 T5488 cc and,3L
R3593 T5491 T5488 conj 3M,3L
R3594 T5492 T5488 punct ),3L
R3595 T5493 T5451 punct .,resembled
R3596 T5495 T5496 amod Immunocytological,analysis
R3597 T5496 T5497 nsubj analysis,showed
R3598 T5498 T5496 prep of,analysis
R3599 T5499 T5500 compound spread,chromosomes
R3600 T5500 T5498 pobj chromosomes,of
R3601 T5501 T5502 det a,failure
R3602 T5502 T5497 dobj failure,showed
R3603 T5503 T5502 prep of,failure
R3604 T5504 T5505 amod homologous,synapsis
R3605 T5505 T5503 pobj synapsis,of
R3606 T5506 T5505 compound chromosome,synapsis
R3607 T5507 T5502 prep in,failure
R3608 T5508 T5509 preconj both,spermatocytes
R3609 T5509 T5507 pobj spermatocytes,in
R3610 T5510 T5509 det the,spermatocytes
R3611 T5511 T5509 nmod Rec8,spermatocytes
R3612 T5512 T5511 punct −,Rec8
R3613 T5513 T5511 punct /,Rec8
R3614 T5514 T5511 punct −,Rec8
R3615 T5515 T5511 cc and,Rec8
R3616 T5516 T5517 nmod Rec8,Gt
R3617 T5517 T5511 conj Gt,Rec8
R3618 T5518 T5516 punct −,Rec8
R3619 T5519 T5516 punct /,Rec8
R3620 T5520 T5516 punct −,Rec8
R3621 T5521 T5517 compound Trip13Gt,Gt
R3622 T5522 T5517 punct /,Gt
R3623 T5523 T5497 punct ", ",showed
R3624 T5524 T5525 mark as,reported
R3625 T5525 T5497 advcl reported,showed
R3626 T5526 T5525 advmod previously,reported
R3627 T5527 T5525 prep for,reported
R3628 T5528 T5529 compound Rec8,mutants
R3629 T5529 T5527 pobj mutants,for
R3630 T5530 T5531 punct (,5D
R3631 T5531 T5497 parataxis 5D,showed
R3632 T5532 T5531 compound Figure,5D
R3633 T5533 T5531 cc and,5D
R3634 T5534 T5531 conj 5E,5D
R3635 T5535 T5531 punct ),5D
R3636 T5536 T5537 punct [,40
R3637 T5537 T5497 parataxis 40,showed
R3638 T5538 T5537 nummod 39,40
R3639 T5539 T5537 punct ",",40
R3640 T5540 T5537 punct ],40
R3641 T5541 T5497 punct .,showed
R3642 T5543 T5544 mark Although,indicate
R3643 T5544 T5547 advcl indicate,reported
R3644 T5545 T5546 amod subsequent,reports
R3645 T5546 T5544 nsubj reports,indicate
R3646 T5548 T5544 advmod otherwise,indicate
R3647 T5549 T5550 punct [,12
R3648 T5550 T5544 parataxis 12,indicate
R3649 T5551 T5550 nummod 10,12
R3650 T5552 T5550 punct ",",12
R3651 T5553 T5550 punct ],12
R3652 T5554 T5547 punct ", ",reported
R3653 T5555 T5547 nsubjpass deletion,reported
R3654 T5556 T5555 prep of,deletion
R3655 T5557 T5556 pobj PCH2,of
R3656 T5558 T5555 prep in,deletion
R3657 T5559 T5558 pobj yeast,in
R3658 T5560 T5547 auxpass was,reported
R3659 T5561 T5547 advmod originally,reported
R3660 T5562 T5563 aux to,alleviate
R3661 T5563 T5547 xcomp alleviate,reported
R3662 T5564 T5565 amod meiotic,arrest
R3663 T5565 T5563 dobj arrest,alleviate
R3664 T5566 T5565 acl caused,arrest
R3665 T5567 T5566 agent by,caused
R3666 T5568 T5567 pobj deficiency,by
R3667 T5569 T5568 prep for,deficiency
R3668 T5570 T5571 det the,homolog
R3669 T5571 T5569 pobj homolog,for
R3670 T5572 T5573 npadvmod meiosis,specific
R3671 T5573 T5571 amod specific,homolog
R3672 T5574 T5573 punct -,specific
R3673 T5575 T5571 compound RecA,homolog
R3674 T5576 T5571 appos DMC1,homolog
R3675 T5577 T5578 punct [,8
R3676 T5578 T5547 parataxis 8,reported
R3677 T5579 T5578 punct ],8
R3678 T5580 T5547 punct .,reported
R3679 T5582 T5583 aux To,investigate
R3680 T5583 T5584 advcl investigate,constructed
R3681 T5585 T5586 det this,relationship
R3682 T5586 T5583 dobj relationship,investigate
R3683 T5587 T5583 prep in,investigate
R3684 T5588 T5587 pobj mice,in
R3685 T5589 T5584 punct ", ",constructed
R3686 T5590 T5584 nsubj we,constructed
R3687 T5591 T5584 dobj animals,constructed
R3688 T5592 T5593 advmod doubly,mutant
R3689 T5593 T5591 amod mutant,animals
R3690 T5594 T5593 prep for,mutant
R3691 T5595 T5594 pobj Trip13,for
R3692 T5596 T5595 cc and,Trip13
R3693 T5597 T5595 conj Dmc1,Trip13
R3694 T5598 T5584 punct .,constructed
R3695 T5600 T5601 prep As,arrested
R3696 T5602 T5600 prep in,As
R3697 T5603 T5604 nmod Dmc1,mice
R3698 T5604 T5602 pobj mice,in
R3699 T5605 T5603 punct −,Dmc1
R3700 T5606 T5603 punct /,Dmc1
R3701 T5607 T5603 punct −,Dmc1
R3702 T5608 T5604 punct ", ",mice
R3703 T5609 T5610 prep in,undergo
R3704 T5610 T5604 relcl undergo,mice
R3705 T5611 T5609 pobj which,in
R3706 T5612 T5610 nsubj spermatocytes,undergo
R3707 T5613 T5614 amod meiotic,arrest
R3708 T5614 T5610 dobj arrest,undergo
R3709 T5615 T5610 prep from,undergo
R3710 T5616 T5617 amod defective,repair
R3711 T5617 T5615 pobj repair,from
R3712 T5618 T5617 compound DSB,repair
R3713 T5619 T5617 cc and,repair
R3714 T5620 T5621 amod failed,synapsis
R3715 T5621 T5617 conj synapsis,repair
R3716 T5622 T5621 compound chromosome,synapsis
R3717 T5623 T5624 punct [,16
R3718 T5624 T5610 parataxis 16,undergo
R3719 T5625 T5624 punct ],16
R3720 T5626 T5601 punct ", ",arrested
R3721 T5627 T5601 nsubjpass spermatogenesis,arrested
R3722 T5628 T5627 prep in,spermatogenesis
R3723 T5629 T5630 nmod Dmc1,testes
R3724 T5630 T5628 pobj testes,in
R3725 T5631 T5629 punct −,Dmc1
R3726 T5632 T5629 punct /,Dmc1
R3727 T5633 T5629 punct −,Dmc1
R3728 T5634 T5635 compound Trip13Gt,Gt
R3729 T5635 T5630 compound Gt,testes
R3730 T5636 T5635 punct /,Gt
R3731 T5637 T5601 auxpass was,arrested
R3732 T5638 T5601 advmod uniformly,arrested
R3733 T5639 T5601 prep at,arrested
R3734 T5640 T5641 det the,point
R3735 T5641 T5639 pobj point,at
R3736 T5642 T5643 advmod where,contained
R3737 T5643 T5641 relcl contained,point
R3738 T5644 T5643 nsubj spermatocytes,contained
R3739 T5645 T5643 dobj chromatin,contained
R3740 T5646 T5645 amod characteristic,chromatin
R3741 T5647 T5646 prep of,characteristic
R3742 T5648 T5649 compound zygonema,pachynema
R3743 T5649 T5647 pobj pachynema,of
R3744 T5650 T5649 punct /,pachynema
R3745 T5651 T5652 punct (,3N
R3746 T5652 T5601 parataxis 3N,arrested
R3747 T5653 T5652 compound Figure,3N
R3748 T5654 T5652 punct ),3N
R3749 T5655 T5601 punct .,arrested
R3750 T5657 T5658 amod Immunocytological,analysis
R3751 T5658 T5659 nsubj analysis,indicated
R3752 T5660 T5661 mark that,had
R3753 T5661 T5659 ccomp had,indicated
R3754 T5662 T5663 preconj both,Dmc1
R3755 T5663 T5664 nmod Dmc1,chromosomes
R3756 T5664 T5661 nsubj chromosomes,had
R3757 T5665 T5663 punct −,Dmc1
R3758 T5666 T5663 punct /,Dmc1
R3759 T5667 T5663 punct −,Dmc1
R3760 T5668 T5663 cc and,Dmc1
R3761 T5669 T5670 nmod Dmc1,Gt
R3762 T5670 T5663 conj Gt,Dmc1
R3763 T5671 T5669 punct −,Dmc1
R3764 T5672 T5669 punct /,Dmc1
R3765 T5673 T5669 punct −,Dmc1
R3766 T5674 T5670 compound Trip13Gt,Gt
R3767 T5675 T5670 punct /,Gt
R3768 T5676 T5677 amod extensive,asynapsis
R3769 T5677 T5661 dobj asynapsis,had
R3770 T5678 T5661 prep compared,had
R3771 T5679 T5678 prep to,compared
R3772 T5680 T5681 nmod Trip13Gt,mutants
R3773 T5681 T5679 pobj mutants,to
R3774 T5682 T5681 amod single,mutants
R3775 T5683 T5684 punct (,5H
R3776 T5684 T5661 parataxis 5H,had
R3777 T5685 T5684 nmod Figure,5H
R3778 T5686 T5684 nmod 5F,5H
R3779 T5687 T5684 punct –,5H
R3780 T5688 T5684 punct ),5H
R3781 T5689 T5659 punct ", ",indicated
R3782 T5690 T5659 cc and,indicated
R3783 T5691 T5692 nsubj all,had
R3784 T5692 T5659 conj had,indicated
R3785 T5693 T5694 amod persistent,foci
R3786 T5694 T5692 dobj foci,had
R3787 T5695 T5696 compound RAD51,DMC1
R3788 T5696 T5694 compound DMC1,foci
R3789 T5697 T5696 punct /,DMC1
R3790 T5698 T5694 cc and,foci
R3791 T5699 T5700 amod phosphorylated,H2AX
R3792 T5700 T5694 conj H2AX,foci
R3793 T5701 T5702 punct (,5L
R3794 T5702 T5692 parataxis 5L,had
R3795 T5703 T5702 dep γH2AX,5L
R3796 T5704 T5702 punct ;,5L
R3797 T5705 T5702 nmod Figure,5L
R3798 T5706 T5702 nmod 5I,5L
R3799 T5707 T5702 punct –,5L
R3800 T5708 T5702 punct ),5L
R3801 T5709 T5692 punct ", ",had
R3802 T5710 T5692 advcl confirming,had
R3803 T5711 T5712 mark that,is
R3804 T5712 T5710 ccomp is,confirming
R3805 T5713 T5712 nsubj Dmc1,is
R3806 T5714 T5712 acomp epistatic,is
R3807 T5715 T5714 prep to,epistatic
R3808 T5716 T5715 pobj Trip13,to
R3809 T5717 T5692 punct .,had
R3810 T5719 T5720 advmod Doubly,mutant
R3811 T5720 T5721 amod mutant,females
R3812 T5721 T5722 nsubj females,had
R3813 T5723 T5724 amod residual,ovaries
R3814 T5724 T5722 dobj ovaries,had
R3815 T5725 T5722 punct ", ",had
R3816 T5726 T5722 advcl phenocopying,had
R3817 T5727 T5728 nmod Dmc1,mutants
R3818 T5728 T5726 dobj mutants,phenocopying
R3819 T5729 T5727 punct −,Dmc1
R3820 T5730 T5727 punct /,Dmc1
R3821 T5731 T5727 punct −,Dmc1
R3822 T5732 T5727 cc and,Dmc1
R3823 T5733 T5734 compound Trip13Gt,Gt
R3824 T5734 T5727 conj Gt,Dmc1
R3825 T5735 T5734 punct /,Gt
R3826 T5736 T5728 amod single,mutants
R3827 T5737 T5738 punct (,data
R3828 T5738 T5722 meta data,had
R3829 T5739 T5738 amod unpublished,data
R3830 T5740 T5738 punct ),data
R3831 T5741 T5722 punct .,had
R3832 T5807 T5808 amod Meiotic,Defects
R3833 T5808 T5809 nsubj Defects,Are
R3834 T5810 T5808 prep in,Defects
R3835 T5811 T5812 compound Trip13Gt,Gt
R3836 T5812 T5814 compound Gt,Oocytes
R3837 T5813 T5812 punct /,Gt
R3838 T5814 T5810 pobj Oocytes,in
R3839 T5815 T5816 npadvmod DSB,Dependent
R3840 T5816 T5809 acomp Dependent,Are
R3841 T5817 T5816 punct -,Dependent
R3842 T5819 T5820 compound Epistasis,analysis
R3843 T5820 T5821 nsubj analysis,was
R3844 T5822 T5820 prep of,analysis
R3845 T5823 T5822 pobj females,of
R3846 T5824 T5821 acomp insightful,was
R3847 T5825 T5824 prep with,insightful
R3848 T5826 T5825 pobj respect,with
R3849 T5827 T5826 prep to,respect
R3850 T5828 T5829 det the,cause
R3851 T5829 T5827 pobj cause,to
R3852 T5830 T5829 prep of,cause
R3853 T5831 T5830 pobj arrest,of
R3854 T5832 T5831 prep in,arrest
R3855 T5833 T5834 compound Trip13,mutants
R3856 T5834 T5832 pobj mutants,in
R3857 T5835 T5821 punct .,was
R3858 T5837 T5838 preconj Both,Gt
R3859 T5838 T5846 nsubj Gt,had
R3860 T5839 T5838 nmod Mei1,Gt
R3861 T5840 T5839 punct −,Mei1
R3862 T5841 T5839 punct /,Mei1
R3863 T5842 T5839 punct −,Mei1
R3864 T5843 T5838 punct /,Gt
R3865 T5844 T5838 compound Trip13Gt,Gt
R3866 T5845 T5838 punct /,Gt
R3867 T5847 T5838 cc and,Gt
R3868 T5848 T5849 nmod Spo11,Gt
R3869 T5849 T5856 compound Gt,females
R3870 T5850 T5848 punct −,Spo11
R3871 T5851 T5848 punct /,Spo11
R3872 T5852 T5848 punct −,Spo11
R3873 T5853 T5849 punct /,Gt
R3874 T5854 T5849 compound Trip13Gt,Gt
R3875 T5855 T5849 punct /,Gt
R3876 T5856 T5838 conj females,Gt
R3877 T5857 T5846 dobj ovaries,had
R3878 T5858 T5857 prep with,ovaries
R3879 T5859 T5860 amod numerous,follicles
R3880 T5860 T5858 pobj follicles,with
R3881 T5861 T5857 punct ", ",ovaries
R3882 T5862 T5857 amod identical,ovaries
R3883 T5863 T5862 prep to,identical
R3884 T5864 T5865 nmod Mei1,mutants
R3885 T5865 T5863 pobj mutants,to
R3886 T5866 T5864 cc and,Mei1
R3887 T5867 T5864 conj Spo11,Mei1
R3888 T5868 T5865 amod single,mutants
R3889 T5869 T5870 punct (,3R
R3890 T5870 T5846 parataxis 3R,had
R3891 T5871 T5870 nmod Figure,3R
R3892 T5872 T5870 nmod 3O,3R
R3893 T5873 T5870 punct –,3R
R3894 T5874 T5870 punct ),3R
R3895 T5875 T5846 punct .,had
R3896 T5877 T5878 advmod Thus,are
R3897 T5879 T5878 punct ", ",are
R3898 T5880 T5878 nsubj Spo11,are
R3899 T5881 T5880 cc and,Spo11
R3900 T5882 T5880 conj Mei1,Spo11
R3901 T5883 T5878 acomp epistatic,are
R3902 T5884 T5883 prep to,epistatic
R3903 T5885 T5884 pobj Trip13,to
R3904 T5886 T5878 prep in,are
R3905 T5887 T5886 pobj oogenesis,in
R3906 T5888 T5878 punct ", ",are
R3907 T5889 T5890 advmod just,are
R3908 T5890 T5878 advcl are,are
R3909 T5891 T5890 mark as,are
R3910 T5892 T5890 nsubj they,are
R3911 T5893 T5890 acomp to,are
R3912 T5894 T5893 pobj Dmc1,to
R3913 T5895 T5896 punct [,41
R3914 T5896 T5878 parataxis 41,are
R3915 T5897 T5896 nummod 13,41
R3916 T5898 T5896 punct ",",41
R3917 T5899 T5896 punct ],41
R3918 T5900 T5878 punct .,are
R3919 T5902 T5903 nsubj This,demonstrates
R3920 T5904 T5905 mark that,is
R3921 T5905 T5903 ccomp is,demonstrates
R3922 T5906 T5907 compound oocyte,loss
R3923 T5907 T5905 nsubj loss,is
R3924 T5908 T5907 prep in,loss
R3925 T5909 T5910 compound Trip13Gt,Gt
R3926 T5910 T5912 compound Gt,females
R3927 T5911 T5910 punct /,Gt
R3928 T5912 T5908 pobj females,in
R3929 T5913 T5905 acomp dependent,is
R3930 T5914 T5913 prep on,dependent
R3931 T5915 T5916 compound DSB,formation
R3932 T5916 T5914 pobj formation,on
R3933 T5917 T5903 punct .,demonstrates
R3934 T5919 T5920 prep In,provide
R3935 T5921 T5919 pobj conjunction,In
R3936 T5922 T5921 prep with,conjunction
R3937 T5923 T5924 det the,data
R3938 T5924 T5922 pobj data,with
R3939 T5925 T5924 amod immunohistochemical,data
R3940 T5926 T5920 punct ", ",provide
R3941 T5927 T5928 det these,data
R3942 T5928 T5920 nsubj data,provide
R3943 T5929 T5930 amod strong,evidence
R3944 T5930 T5920 dobj evidence,provide
R3945 T5931 T5932 mark that,is
R3946 T5932 T5930 acl is,evidence
R3947 T5933 T5934 amod meiotic,arrest
R3948 T5934 T5932 nsubj arrest,is
R3949 T5935 T5934 prep in,arrest
R3950 T5936 T5937 compound Trip13,mice
R3951 T5937 T5935 pobj mice,in
R3952 T5938 T5937 compound mutant,mice
R3953 T5939 T5932 prep due,is
R3954 T5940 T5939 pcomp to,due
R3955 T5941 T5939 pobj defects,due
R3956 T5942 T5941 prep in,defects
R3957 T5943 T5944 compound DSB,repair
R3958 T5944 T5942 pobj repair,in
R3959 T5945 T5920 punct .,provide
R3960 T5947 T5948 mark As,expected
R3961 T5948 T5949 advcl expected,were
R3962 T5950 T5949 punct ", ",were
R3963 T5951 T5949 nsubj ovaries,were
R3964 T5952 T5951 prep of,ovaries
R3965 T5953 T5954 nmod Rec8,Trip13
R3966 T5954 T5955 nmod Trip13,mutants
R3967 T5955 T5952 pobj mutants,of
R3968 T5956 T5955 amod double,mutants
R3969 T5957 T5949 acomp devoid,were
R3970 T5958 T5957 prep of,devoid
R3971 T5959 T5958 pobj oocytes,of
R3972 T5960 T5961 mark as,were
R3973 T5961 T5949 advcl were,were
R3974 T5962 T5961 nsubj those,were
R3975 T5963 T5962 prep from,those
R3976 T5964 T5965 preconj either,mutant
R3977 T5965 T5963 pobj mutant,from
R3978 T5966 T5965 amod single,mutant
R3979 T5967 T5968 punct (,3B
R3980 T5968 T5949 parataxis 3B,were
R3981 T5969 T5968 compound Figure,3B
R3982 T5970 T5968 punct ", ",3B
R3983 T5971 T5968 conj 3S,3B
R3984 T5972 T5971 punct ", ",3S
R3985 T5973 T5971 cc and,3S
R3986 T5974 T5971 conj 3T,3S
R3987 T5975 T5968 punct ),3B
R3988 T5976 T5949 punct .,were
R4005 T6565 T6566 amod Genetic,experiments
R4006 T6566 T6567 nsubj experiments,provided
R4007 T6568 T6566 prep in,experiments
R4008 T6569 T6570 compound S.,cerevisiae
R4009 T6570 T6568 pobj cerevisiae,in
R4010 T6571 T6567 dobj evidence,provided
R4011 T6572 T6573 mark that,monitors
R4012 T6573 T6571 acl monitors,evidence
R4013 T6574 T6575 det the,checkpoint
R4014 T6575 T6573 nsubj checkpoint,monitors
R4015 T6576 T6575 compound pachytene,checkpoint
R4016 T6577 T6573 cc and,monitors
R4017 T6578 T6573 conj responds,monitors
R4018 T6579 T6578 prep to,responds
R4019 T6580 T6581 amod recombinational,repair
R4020 T6581 T6573 dobj repair,monitors
R4021 T6582 T6581 compound DSB,repair
R4022 T6583 T6581 cc and,repair
R4023 T6584 T6581 conj synapsis,repair
R4024 T6585 T6573 advmod independently,monitors
R4025 T6586 T6567 punct .,provided
R4026 T6588 T6589 nsubj Wu,concluded
R4027 T6590 T6588 cc and,Wu
R4028 T6591 T6588 conj Burgess,Wu
R4029 T6592 T6593 mark that,is
R4030 T6593 T6589 ccomp is,concluded
R4031 T6594 T6595 det the,checkpoint
R4032 T6595 T6593 nsubj checkpoint,is
R4033 T6596 T6595 compound repair,checkpoint
R4034 T6597 T6598 compound RAD17,SAE2
R4035 T6598 T6600 npadvmod SAE2,dependent
R4036 T6599 T6598 punct -,SAE2
R4037 T6600 T6593 acomp dependent,is
R4038 T6601 T6593 punct ", ",is
R4039 T6602 T6603 mark while,is
R4040 T6603 T6593 advcl is,is
R4041 T6604 T6605 det the,checkpoint
R4042 T6605 T6603 nsubj checkpoint,is
R4043 T6606 T6605 compound synapsis,checkpoint
R4044 T6607 T6608 compound PCH2,ZIP1
R4045 T6608 T6610 npadvmod ZIP1,dependent
R4046 T6609 T6608 punct -,ZIP1
R4047 T6610 T6603 acomp dependent,is
R4048 T6611 T6612 punct [,12
R4049 T6612 T6589 parataxis 12,concluded
R4050 T6613 T6612 punct ],12
R4051 T6614 T6589 punct .,concluded
R4052 T6616 T6617 prep Of,have
R4053 T6618 T6619 det these,genes
R4054 T6619 T6616 pobj genes,Of
R4055 T6620 T6619 nummod four,genes
R4056 T6621 T6617 punct ", ",have
R4057 T6622 T6617 nsubj SAE2,have
R4058 T6623 T6622 cc and,SAE2
R4059 T6624 T6622 conj ZIP1,SAE2
R4060 T6625 T6617 aux do,have
R4061 T6626 T6617 neg not,have
R4062 T6627 T6628 amod clear,orthologs
R4063 T6628 T6617 dobj orthologs,have
R4064 T6629 T6628 amod mammalian,orthologs
R4065 T6630 T6617 punct (,have
R4066 T6631 T6632 mark although,be
R4067 T6632 T6617 advcl be,have
R4068 T6633 T6632 nsubj SYCP1,be
R4069 T6634 T6632 aux may,be
R4070 T6635 T6636 det a,ortholog
R4071 T6636 T6632 attr ortholog,be
R4072 T6637 T6636 amod functional,ortholog
R4073 T6638 T6636 prep of,ortholog
R4074 T6639 T6638 pobj ZIP1,of
R4075 T6640 T6617 punct ),have
R4076 T6641 T6617 punct ", ",have
R4077 T6642 T6617 cc and,have
R4078 T6643 T6644 nsubj mutation,causes
R4079 T6644 T6617 conj causes,have
R4080 T6645 T6643 prep of,mutation
R4081 T6646 T6647 det the,ortholog
R4082 T6647 T6645 pobj ortholog,of
R4083 T6648 T6649 compound mouse,RAD17
R4084 T6649 T6647 compound RAD17,ortholog
R4085 T6650 T6647 punct ", ",ortholog
R4086 T6651 T6647 appos Rad1,ortholog
R4087 T6652 T6644 punct ", ",causes
R4088 T6653 T6644 advmod presumably,causes
R4089 T6654 T6655 amod embryonic,lethality
R4090 T6655 T6644 dobj lethality,causes
R4091 T6656 T6657 punct [,42
R4092 T6657 T6644 parataxis 42,causes
R4093 T6658 T6657 punct ],42
R4094 T6659 T6644 punct .,causes
R4095 T6661 T6662 advmod Thus,was
R4096 T6663 T6662 punct ", ",was
R4097 T6664 T6665 amod mutational,analysis
R4098 T6665 T6662 nsubj analysis,was
R4099 T6666 T6665 prep of,analysis
R4100 T6667 T6668 compound mouse,Pch2
R4101 T6668 T6666 pobj Pch2,of
R4102 T6669 T6668 punct (,Pch2
R4103 T6670 T6668 appos Trip13,Pch2
R4104 T6671 T6665 punct ),analysis
R4105 T6672 T6665 punct ", ",analysis
R4106 T6673 T6674 dep which,is
R4107 T6674 T6665 relcl is,analysis
R4108 T6675 T6674 advmod also,is
R4109 T6676 T6674 acomp critical,is
R4110 T6677 T6676 prep for,critical
R4111 T6678 T6679 det the,checkpoint
R4112 T6679 T6677 pobj checkpoint,for
R4113 T6680 T6679 compound synapsis,checkpoint
R4114 T6681 T6674 prep in,is
R4115 T6682 T6683 compound C.,elegans
R4116 T6683 T6681 pobj elegans,in
R4117 T6684 T6685 punct [,2
R4118 T6685 T6674 parataxis 2,is
R4119 T6686 T6685 punct ],2
R4120 T6687 T6662 punct ", ",was
R4121 T6688 T6689 det the,option
R4122 T6689 T6662 attr option,was
R4123 T6690 T6689 amod best,option
R4124 T6691 T6689 amod remaining,option
R4125 T6692 T6693 aux to,evaluate
R4126 T6693 T6662 advcl evaluate,was
R4127 T6694 T6695 amod potential,conservation
R4128 T6695 T6693 dobj conservation,evaluate
R4129 T6696 T6695 amod functional,conservation
R4130 T6697 T6695 prep in,conservation
R4131 T6698 T6699 amod mammalian,control
R4132 T6699 T6697 pobj control,in
R4133 T6700 T6701 amod meiotic,checkpoint
R4134 T6701 T6699 compound checkpoint,control
R4135 T6702 T6662 punct .,was
R4136 T6704 T6705 poss Our,results
R4137 T6705 T6706 nsubj results,demonstrate
R4138 T6707 T6708 mark that,is
R4139 T6708 T6706 ccomp is,demonstrate
R4140 T6709 T6708 prep in,is
R4141 T6710 T6709 pobj mice,in
R4142 T6711 T6708 punct ", ",is
R4143 T6712 T6713 det the,function
R4144 T6713 T6708 nsubj function,is
R4145 T6714 T6713 amod primary,function
R4146 T6715 T6713 amod meiotic,function
R4147 T6716 T6713 prep of,function
R4148 T6717 T6716 pobj TRIP13,of
R4149 T6718 T6708 prep in,is
R4150 T6719 T6718 pobj recombination,in
R4151 T6720 T6719 appos itself,recombination
R4152 T6721 T6706 punct .,demonstrate
R4153 T6723 T6724 nsubj We,found
R4154 T6725 T6726 det no,evidence
R4155 T6726 T6724 dobj evidence,found
R4156 T6727 T6728 mark that,involved
R4157 T6728 T6726 acl involved,evidence
R4158 T6729 T6728 nsubjpass it,involved
R4159 T6730 T6728 auxpass is,involved
R4160 T6731 T6728 prep in,involved
R4161 T6732 T6733 compound pachytene,checkpoint
R4162 T6733 T6734 compound checkpoint,control
R4163 T6734 T6731 pobj control,in
R4164 T6735 T6724 punct .,found
R4165 T6737 T6738 poss Our,data
R4166 T6738 T6739 nsubj data,suggest
R4167 T6740 T6741 mark that,resolved
R4168 T6741 T6739 ccomp resolved,suggest
R4169 T6742 T6743 mark while,proceed
R4170 T6743 T6741 advcl proceed,resolved
R4171 T6744 T6745 compound recombination,events
R4172 T6745 T6743 nsubj events,proceed
R4173 T6746 T6745 acl destined,events
R4174 T6747 T6748 aux to,resolved
R4175 T6748 T6746 xcomp resolved,destined
R4176 T6749 T6748 auxpass be,resolved
R4177 T6750 T6748 prep as,resolved
R4178 T6751 T6750 pobj COs,as
R4179 T6752 T6743 aux can,proceed
R4180 T6753 T6743 advmod normally,proceed
R4181 T6754 T6743 prep in,proceed
R4182 T6755 T6756 compound Trip13,mutants
R4183 T6756 T6754 pobj mutants,in
R4184 T6757 T6741 punct ", ",resolved
R4185 T6758 T6741 nsubjpass DSBs,resolved
R4186 T6759 T6760 dep that,enter
R4187 T6760 T6758 relcl enter,DSBs
R4188 T6761 T6762 det the,pathway
R4189 T6762 T6760 dobj pathway,enter
R4190 T6763 T6762 compound NCO,pathway
R4191 T6764 T6762 compound repair,pathway
R4192 T6765 T6741 auxpass are,resolved
R4193 T6766 T6741 advmod incompletely,resolved
R4194 T6767 T6741 cc or,resolved
R4195 T6768 T6741 conj processed,resolved
R4196 T6769 T6768 advmod inefficiently,processed
R4197 T6770 T6739 punct .,suggest
R4198 T6772 T6773 det This,hypothesis
R4199 T6773 T6774 nsubj hypothesis,is
R4200 T6775 T6774 acomp compatible,is
R4201 T6776 T6775 prep with,compatible
R4202 T6777 T6778 amod current,knowledge
R4203 T6778 T6776 pobj knowledge,with
R4204 T6779 T6778 prep of,knowledge
R4205 T6780 T6781 amod meiotic,recombination
R4206 T6781 T6782 compound recombination,pathways
R4207 T6782 T6779 pobj pathways,of
R4208 T6783 T6774 punct .,is
R4209 T6785 T6786 prep In,are
R4210 T6786 T6794 ccomp are,have
R4211 T6787 T6788 compound S.,cerevisiae
R4212 T6788 T6785 pobj cerevisiae,In
R4213 T6789 T6786 punct ", ",are
R4214 T6790 T6791 nmod CO,pathways
R4215 T6791 T6786 nsubj pathways,are
R4216 T6792 T6790 cc and,CO
R4217 T6793 T6790 conj NCO,CO
R4218 T6795 T6786 acomp distinct,are
R4219 T6796 T6797 punct [,43
R4220 T6797 T6786 parataxis 43,are
R4221 T6798 T6797 punct ],43
R4222 T6799 T6794 punct ;,have
R4223 T6800 T6794 nsubj they,have
R4224 T6801 T6802 amod different,intermediates
R4225 T6802 T6794 dobj intermediates,have
R4226 T6803 T6802 compound recombination,intermediates
R4227 T6804 T6794 punct ", ",have
R4228 T6805 T6794 cc and,have
R4229 T6806 T6794 conj are,have
R4230 T6807 T6806 acomp dependent,are
R4231 T6808 T6807 prep upon,dependent
R4232 T6809 T6810 amod different,proteins
R4233 T6810 T6808 pobj proteins,upon
R4234 T6811 T6812 punct [,45
R4235 T6812 T6806 parataxis 45,are
R4236 T6813 T6812 nummod 44,45
R4237 T6814 T6812 punct ",",45
R4238 T6815 T6812 punct ],45
R4239 T6816 T6794 punct .,have
R4240 T6818 T6819 nsubj Mice,appear
R4241 T6820 T6819 advmod also,appear
R4242 T6821 T6822 aux to,have
R4243 T6822 T6819 xcomp have,appear
R4244 T6823 T6824 amod independent,pathways
R4245 T6824 T6822 dobj pathways,have
R4246 T6825 T6824 nmod CO,pathways
R4247 T6826 T6825 cc versus,CO
R4248 T6827 T6825 conj NCO,CO
R4249 T6828 T6824 compound recombination,pathways
R4250 T6829 T6830 punct [,46
R4251 T6830 T6819 parataxis 46,appear
R4252 T6831 T6830 punct ],46
R4253 T6832 T6819 punct .,appear
R4254 T6834 T6835 prep As,require
R4255 T6836 T6834 prep in,As
R4256 T6837 T6836 pobj yeast,in
R4257 T6838 T6835 punct ", ",require
R4258 T6839 T6835 nsubj both,require
R4259 T6840 T6841 npadvmod SPO11,induced
R4260 T6841 T6843 amod induced,breaks
R4261 T6842 T6841 punct -,induced
R4262 T6843 T6835 dobj breaks,require
R4263 T6844 T6835 punct ", ",require
R4264 T6845 T6835 cc but,require
R4265 T6846 T6847 advmod only,pathway
R4266 T6847 T6850 nsubj pathway,requires
R4267 T6848 T6847 det the,pathway
R4268 T6849 T6847 compound CO,pathway
R4269 T6850 T6835 conj requires,require
R4270 T6851 T6850 dobj MLH1,requires
R4271 T6852 T6850 punct .,requires
R4272 T6854 T6855 det Both,types
R4273 T6855 T6856 nsubjpass types,formed
R4274 T6857 T6855 prep of,types
R4275 T6858 T6859 amod recombinant,products
R4276 T6859 T6857 pobj products,of
R4277 T6860 T6856 auxpass are,formed
R4278 T6861 T6856 prep by,formed
R4279 T6862 T6863 amod mid,late
R4280 T6863 T6865 amod late,pachynema
R4281 T6864 T6863 punct -,late
R4282 T6865 T6861 pobj pachynema,by
R4283 T6866 T6856 punct .,formed
R4284 T6868 T6869 det Another,possibility
R4285 T6869 T6870 nsubj possibility,is
R4286 T6871 T6872 mark that,are
R4287 T6872 T6870 ccomp are,is
R4288 T6873 T6874 det the,defects
R4289 T6874 T6872 nsubj defects,are
R4290 T6875 T6874 compound recombination,defects
R4291 T6876 T6877 det a,result
R4292 T6877 T6872 attr result,are
R4293 T6878 T6877 prep of,result
R4294 T6879 T6880 amod defective,recombination
R4295 T6880 T6878 pobj recombination,of
R4296 T6881 T6880 amod intersister,recombination
R4297 T6882 T6870 punct .,is
R4298 T6884 T6885 advmod However,suppressed
R4299 T6886 T6885 punct ", ",suppressed
R4300 T6887 T6888 det this,type
R4301 T6888 T6885 nsubjpass type,suppressed
R4302 T6889 T6888 prep of,type
R4303 T6890 T6891 compound DSB,repair
R4304 T6891 T6889 pobj repair,of
R4305 T6892 T6885 auxpass is,suppressed
R4306 T6893 T6885 prep in,suppressed
R4307 T6894 T6895 amod meiotic,cells
R4308 T6895 T6893 pobj cells,in
R4309 T6896 T6885 punct .,suppressed
R4310 T6898 T6899 nsubj Ablation,disrupt
R4311 T6900 T6898 prep of,Ablation
R4312 T6901 T6900 pobj RAD54,of
R4313 T6902 T6901 punct ", ",RAD54
R4314 T6903 T6904 dep which,mediates
R4315 T6904 T6901 relcl mediates,RAD54
R4316 T6905 T6906 amod intersister,recombination
R4317 T6906 T6904 dobj recombination,mediates
R4318 T6907 T6906 prep in,recombination
R4319 T6908 T6907 pobj yeast,in
R4320 T6909 T6899 punct ", ",disrupt
R4321 T6910 T6899 aux does,disrupt
R4322 T6911 T6899 neg not,disrupt
R4323 T6912 T6899 advmod significantly,disrupt
R4324 T6913 T6899 dobj meiosis,disrupt
R4325 T6914 T6899 prep in,disrupt
R4326 T6915 T6916 preconj either,yeast
R4327 T6916 T6914 pobj yeast,in
R4328 T6917 T6916 cc or,yeast
R4329 T6918 T6916 conj mice,yeast
R4330 T6919 T6920 punct [,48
R4331 T6920 T6899 parataxis 48,disrupt
R4332 T6921 T6920 nummod 47,48
R4333 T6922 T6920 punct ",",48
R4334 T6923 T6920 punct ],48
R4335 T6924 T6899 punct .,disrupt
R4336 T6926 T6927 advmod Interestingly,display
R4337 T6928 T6927 punct ", ",display
R4338 T6929 T6930 npadvmod RAD54,deficient
R4339 T6930 T6932 amod deficient,spermatocytes
R4340 T6931 T6930 punct -,deficient
R4341 T6932 T6927 nsubj spermatocytes,display
R4342 T6933 T6934 amod abnormal,persistence
R4343 T6934 T6927 dobj persistence,display
R4344 T6935 T6934 prep of,persistence
R4345 T6936 T6937 compound RAD51,foci
R4346 T6937 T6935 pobj foci,of
R4347 T6938 T6927 prep on,display
R4348 T6939 T6940 compound pachytene,chromosomes
R4349 T6940 T6938 pobj chromosomes,on
R4350 T6941 T6940 punct ", ",chromosomes
R4351 T6942 T6940 amod similar,chromosomes
R4352 T6943 T6942 prep to,similar
R4353 T6944 T6943 pobj those,to
R4354 T6945 T6944 prep in,those
R4355 T6946 T6947 compound TRIP13,mice
R4356 T6947 T6945 pobj mice,in
R4357 T6948 T6927 punct ", ",display
R4358 T6949 T6927 cc but,display
R4359 T6950 T6951 expl there,are
R4360 T6951 T6927 conj are,display
R4361 T6952 T6953 det no,effects
R4362 T6953 T6951 attr effects,are
R4363 T6954 T6953 amod deleterious,effects
R4364 T6955 T6953 prep on,effects
R4365 T6956 T6957 amod meiotic,progression
R4366 T6957 T6955 pobj progression,on
R4367 T6958 T6957 cc or,progression
R4368 T6959 T6957 conj fertility,progression
R4369 T6960 T6961 punct [,49
R4370 T6961 T6951 parataxis 49,are
R4371 T6962 T6961 punct ],49
R4372 T6963 T6951 punct .,are
R4373 T6965 T6966 nsubj Data,indicate
R4374 T6967 T6965 prep from,Data
R4375 T6968 T6969 amod budding,yeast
R4376 T6969 T6967 pobj yeast,from
R4377 T6970 T6966 advmod also,indicate
R4378 T6971 T6972 mark that,functions
R4379 T6972 T6966 ccomp functions,indicate
R4380 T6973 T6972 nsubj Pch2p,functions
R4381 T6974 T6972 prep in,functions
R4382 T6975 T6974 pobj recombination,in
R4383 T6976 T6966 punct .,indicate
R4384 T6978 T6979 nsubj Deletion,delays
R4385 T6980 T6978 prep of,Deletion
R4386 T6981 T6980 pobj PCH2,of
R4387 T6982 T6983 amod meiotic,progression
R4388 T6983 T6979 dobj progression,delays
R4389 T6984 T6979 prep by,delays
R4390 T6985 T6986 punct ∼,2
R4391 T6986 T6987 nummod 2,h
R4392 T6987 T6984 pobj h,by
R4393 T6988 T6979 prep in,delays
R4394 T6989 T6990 compound SK1,yeast
R4395 T6990 T6988 pobj yeast,in
R4396 T6991 T6979 punct ", ",delays
R4397 T6992 T6979 cc and,delays
R4398 T6993 T6979 conj causes,delays
R4399 T6994 T6995 det a,decrease
R4400 T6995 T6993 dobj decrease,causes
R4401 T6996 T6995 amod minor,decrease
R4402 T6997 T6995 prep in,decrease
R4403 T6998 T6999 compound ascus,formation
R4404 T6999 T6997 pobj formation,in
R4405 T7000 T7001 punct [,50
R4406 T7001 T6993 parataxis 50,causes
R4407 T7002 T7001 punct ],50
R4408 T7003 T6979 punct .,delays
R4409 T7005 T7006 nsubj DSBs,persist
R4410 T7007 T7008 punct >,2
R4411 T7008 T7009 nummod 2,h
R4412 T7009 T7010 npadvmod h,longer
R4413 T7010 T7006 advmod longer,persist
R4414 T7011 T7006 prep in,persist
R4415 T7012 T7013 nmod pch2,yeast
R4416 T7013 T7011 pobj yeast,in
R4417 T7014 T7013 punct Δ,yeast
R4418 T7015 T7006 prep than,persist
R4419 T7016 T7015 prep in,than
R4420 T7017 T7018 amod wild,type
R4421 T7018 T7016 pobj type,in
R4422 T7019 T7006 punct ", ",persist
R4423 T7020 T7006 cc and,persist
R4424 T7021 T7022 nsubj hyperresection,is
R4425 T7022 T7006 conj is,persist
R4426 T7023 T7021 prep of,hyperresection
R4427 T7024 T7023 pobj DSBs,of
R4428 T7025 T7021 prep in,hyperresection
R4429 T7026 T7027 nmod dmc1,pch2
R4430 T7027 T7029 nmod pch2,mutants
R4431 T7028 T7027 punct Δ,pch2
R4432 T7029 T7025 pobj mutants,in
R4433 T7030 T7027 punct Δ,pch2
R4434 T7031 T7029 amod double,mutants
R4435 T7032 T7022 acomp lower,is
R4436 T7033 T7032 prep than,lower
R4437 T7034 T7033 prep in,than
R4438 T7035 T7036 nmod dmc1,cells
R4439 T7036 T7034 pobj cells,in
R4440 T7037 T7035 punct Δ,dmc1
R4441 T7038 T7039 punct [,10
R4442 T7039 T7022 parataxis 10,is
R4443 T7040 T7039 punct ],10
R4444 T7041 T7022 punct .,is
R4445 T7043 T7044 advmod Additionally,reported
R4446 T7045 T7044 punct ", ",reported
R4447 T7046 T7044 nsubjpass it,reported
R4448 T7047 T7044 auxpass was,reported
R4449 T7048 T7049 mark that,had
R4450 T7049 T7044 ccomp had,reported
R4451 T7050 T7051 compound pch2,Δ
R4452 T7051 T7052 compound Δ,yeast
R4453 T7052 T7049 nsubj yeast,had
R4454 T7053 T7054 det a,delay
R4455 T7054 T7049 dobj delay,had
R4456 T7055 T7054 nmod meiosis,delay
R4457 T7056 T7055 nummod I,meiosis
R4458 T7057 T7054 amod dependent,delay
R4459 T7058 T7057 prep on,dependent
R4460 T7059 T7060 det the,checkpoint
R4461 T7060 T7058 pobj checkpoint,on
R4462 T7061 T7062 compound RAD17,SAE2
R4463 T7062 T7060 compound SAE2,checkpoint
R4464 T7063 T7062 punct –,SAE2
R4465 T7064 T7065 dep that,monitors
R4466 T7065 T7060 relcl monitors,checkpoint
R4467 T7066 T7067 compound recombination,intermediates
R4468 T7067 T7065 dobj intermediates,monitors
R4469 T7068 T7069 punct [,12
R4470 T7069 T7044 parataxis 12,reported
R4471 T7070 T7069 punct ],12
R4472 T7071 T7044 punct .,reported
R4473 T7073 T7074 advmod However,is
R4474 T7075 T7074 punct ", ",is
R4475 T7076 T7077 det the,role
R4476 T7077 T7074 nsubj role,is
R4477 T7078 T7077 amod exact,role
R4478 T7079 T7077 prep of,role
R4479 T7080 T7079 pobj TRIP13,of
R4480 T7081 T7080 punct (,TRIP13
R4481 T7082 T7080 cc or,TRIP13
R4482 T7083 T7080 conj Pch2,TRIP13
R4483 T7084 T7077 punct ),role
R4484 T7085 T7077 prep in,role
R4485 T7086 T7085 pobj recombination,in
R4486 T7087 T7074 acomp unclear,is
R4487 T7088 T7074 punct .,is
R4488 T7090 T7091 mark Because,occurs
R4489 T7091 T7093 advcl occurs,suggest
R4490 T7092 T7091 nsubj synapsis,occurs
R4491 T7094 T7091 prep in,occurs
R4492 T7095 T7096 npadvmod TRIP13,deficient
R4493 T7096 T7098 amod deficient,spermatocytes
R4494 T7097 T7096 punct -,deficient
R4495 T7098 T7094 pobj spermatocytes,in
R4496 T7099 T7091 cc and,occurs
R4497 T7100 T7091 conj is,occurs
R4498 T7101 T7100 acomp dependent,is
R4499 T7102 T7101 prep on,dependent
R4500 T7103 T7104 compound DSB,formation
R4501 T7104 T7102 pobj formation,on
R4502 T7105 T7104 punct (,formation
R4503 T7106 T7104 appos activity,formation
R4504 T7107 T7106 prep of,activity
R4505 T7108 T7107 pobj SPO11,of
R4506 T7109 T7108 cc and,SPO11
R4507 T7110 T7108 conj MEI1,SPO11
R4508 T7111 T7093 punct ),suggest
R4509 T7112 T7093 punct ", ",suggest
R4510 T7113 T7093 nsubj we,suggest
R4511 T7114 T7115 mark that,functions
R4512 T7115 T7093 advcl functions,suggest
R4513 T7116 T7115 nsubj TRIP13,functions
R4514 T7117 T7115 prep after,functions
R4515 T7118 T7119 compound homology,recognition
R4516 T7119 T7117 pobj recognition,after
R4517 T7120 T7119 cc and,recognition
R4518 T7121 T7122 compound strand,exchange
R4519 T7122 T7119 conj exchange,recognition
R4520 T7123 T7115 punct ", ",functions
R4521 T7124 T7115 cc and,functions
R4522 T7125 T7126 mark that,are
R4523 T7126 T7115 conj are,functions
R4524 T7127 T7128 compound recombination,events
R4525 T7128 T7126 nsubj events,are
R4526 T7129 T7128 acl entering,events
R4527 T7130 T7131 det the,pathway
R4528 T7131 T7129 dobj pathway,entering
R4529 T7132 T7133 compound CO,repair
R4530 T7133 T7131 compound repair,pathway
R4531 T7134 T7135 advmod either,completed
R4532 T7135 T7126 acomp completed,are
R4533 T7136 T7135 cc or,completed
R4534 T7137 T7138 advmod nearly,so
R4535 T7138 T7135 conj so,completed
R4536 T7139 T7126 punct (,are
R4537 T7140 T7141 mark because,resulted
R4538 T7141 T7126 advcl resulted,are
R4539 T7142 T7141 nsubj OA,resulted
R4540 T7143 T7142 amod treated,OA
R4541 T7144 T7141 prep in,resulted
R4542 T7145 T7146 amod bivalent,chromosomes
R4543 T7146 T7144 pobj chromosomes,in
R4544 T7147 T7093 punct ),suggest
R4545 T7148 T7093 punct .,suggest
R4546 T7150 T7151 nummod One,possibility
R4547 T7151 T7152 nsubj possibility,is
R4548 T7153 T7151 prep for,possibility
R4549 T7154 T7155 poss TRIP13,role
R4550 T7155 T7153 pobj role,for
R4551 T7156 T7154 case ′s,TRIP13
R4552 T7157 T7155 prep in,role
R4553 T7158 T7157 pobj recombination,in
R4554 T7159 T7160 mark that,involved
R4555 T7160 T7152 ccomp involved,is
R4556 T7161 T7160 nsubjpass it,involved
R4557 T7162 T7160 auxpass is,involved
R4558 T7163 T7160 advmod directly,involved
R4559 T7164 T7160 prep in,involved
R4560 T7165 T7166 det a,step
R4561 T7166 T7164 pobj step,in
R4562 T7167 T7166 amod specific,step
R4563 T7168 T7167 prep to,specific
R4564 T7169 T7168 pobj resolution,to
R4565 T7170 T7169 prep of,resolution
R4566 T7171 T7172 compound NCO,recombination
R4567 T7172 T7173 compound recombination,intermediates
R4568 T7173 T7170 pobj intermediates,of
R4569 T7174 T7152 punct .,is
R4570 T7176 T7177 det Another,possibility
R4571 T7177 T7178 nsubj possibility,is
R4572 T7179 T7180 mark that,required
R4573 T7180 T7178 ccomp required,is
R4574 T7181 T7180 nsubjpass TRIP13,required
R4575 T7182 T7180 auxpass is,required
R4576 T7183 T7180 prep for,required
R4577 T7184 T7183 pobj disassembly,for
R4578 T7185 T7184 prep of,disassembly
R4579 T7186 T7187 npadvmod NCO,recombinational
R4580 T7187 T7188 amod recombinational,repair
R4581 T7188 T7189 compound repair,complexes
R4582 T7189 T7185 pobj complexes,of
R4583 T7190 T7191 punct [,51
R4584 T7191 T7189 parataxis 51,complexes
R4585 T7192 T7191 punct ],51
R4586 T7193 T7189 acl containing,complexes
R4587 T7194 T7195 det those,proteins
R4588 T7195 T7193 dobj proteins,containing
R4589 T7196 T7197 dep that,persist
R4590 T7197 T7195 relcl persist,proteins
R4591 T7198 T7197 advmod abnormally,persist
R4592 T7199 T7197 prep on,persist
R4593 T7200 T7201 compound Trip13Gt,Gt
R4594 T7201 T7203 compound Gt,chromosomes
R4595 T7202 T7201 punct /,Gt
R4596 T7203 T7199 pobj chromosomes,on
R4597 T7204 T7203 compound pachytene,chromosomes
R4598 T7205 T7178 punct .,is
R4599 T7207 T7208 advmod Notably,has
R4600 T7209 T7208 punct ", ",has
R4601 T7210 T7208 nsubj TRIP13,has
R4602 T7211 T7212 nummod two,domains
R4603 T7212 T7208 dobj domains,has
R4604 T7213 T7212 amod putative,domains
R4605 T7214 T7212 compound ATPase,domains
R4606 T7215 T7212 punct ", ",domains
R4607 T7216 T7217 det a,signature
R4608 T7217 T7212 appos signature,domains
R4609 T7218 T7217 prep of,signature
R4610 T7219 T7220 compound AAA,ATPase
R4611 T7220 T7222 compound ATPase,chaperones
R4612 T7221 T7220 punct -,ATPase
R4613 T7222 T7218 pobj chaperones,of
R4614 T7223 T7224 compound ClpA,B
R4615 T7224 T7222 compound B,chaperones
R4616 T7225 T7224 punct /,B
R4617 T7226 T7227 dep that,perform
R4618 T7227 T7222 relcl perform,chaperones
R4619 T7228 T7229 nmod protein,disassembly
R4620 T7229 T7227 dobj disassembly,perform
R4621 T7230 T7228 cc or,protein
R4622 T7231 T7232 compound protein,DNA
R4623 T7232 T7234 compound DNA,complex
R4624 T7233 T7232 punct /,DNA
R4625 T7234 T7228 conj complex,protein
R4626 T7235 T7236 punct [,52
R4627 T7236 T7208 parataxis 52,has
R4628 T7237 T7236 punct ],52
R4629 T7238 T7208 punct .,has
R4630 T7240 T7241 det These,roles
R4631 T7241 T7244 nsubjpass roles,limited
R4632 T7242 T7241 amod potential,roles
R4633 T7243 T7241 compound recombination,roles
R4634 T7245 T7244 aux might,limited
R4635 T7246 T7244 neg not,limited
R4636 T7247 T7244 auxpass be,limited
R4637 T7248 T7244 prep to,limited
R4638 T7249 T7248 pobj meiosis,to
R4639 T7250 T7244 punct ", ",limited
R4640 T7251 T7252 mark since,transcribed
R4641 T7252 T7244 advcl transcribed,limited
R4642 T7253 T7252 nsubjpass Trip13,transcribed
R4643 T7254 T7252 auxpass is,transcribed
R4644 T7255 T7252 advmod widely,transcribed
R4645 T7256 T7252 cc and,transcribed
R4646 T7257 T7258 det the,animals
R4647 T7258 T7260 nsubj animals,exhibited
R4648 T7259 T7258 compound mutant,animals
R4649 T7260 T7252 conj exhibited,transcribed
R4650 T7261 T7262 amod developmental,defects
R4651 T7262 T7260 dobj defects,exhibited
R4652 T7263 T7244 punct .,limited
R4653 T7265 T7266 advmod Finally,play
R4654 T7267 T7266 punct ", ",play
R4655 T7268 T7266 nsubj TRIP13,play
R4656 T7269 T7266 aux might,play
R4657 T7270 T7271 det an,role
R4658 T7271 T7266 dobj role,play
R4659 T7272 T7271 amod indirect,role
R4660 T7273 T7271 punct ", ",role
R4661 T7274 T7275 amod such,as
R4662 T7275 T7271 prep as,role
R4663 T7276 T7275 pcomp providing,as
R4664 T7277 T7278 det a,signal
R4665 T7278 T7276 dobj signal,providing
R4666 T7279 T7278 punct “,signal
R4667 T7280 T7278 nmod licensing,signal
R4668 T7281 T7278 punct ”,signal
R4669 T7282 T7278 prep for,signal
R4670 T7283 T7284 det the,resolution
R4671 T7284 T7282 pobj resolution,for
R4672 T7285 T7284 prep of,resolution
R4673 T7286 T7287 compound NCO,intermediates
R4674 T7287 T7285 pobj intermediates,of
R4675 T7288 T7284 cc and,resolution
R4676 T7289 T7284 conj completion,resolution
R4677 T7290 T7289 prep of,completion
R4678 T7291 T7290 pobj meiosis,of
R4679 T7292 T7266 punct .,play
R4680 T7294 T7295 prep Regarding,indicate
R4681 T7296 T7297 det the,cause
R4682 T7297 T7294 pobj cause,Regarding
R4683 T7298 T7297 prep of,cause
R4684 T7299 T7300 compound cell,death
R4685 T7300 T7298 pobj death,of
R4686 T7301 T7300 prep in,death
R4687 T7302 T7303 compound Trip13,mutants
R4688 T7303 T7301 pobj mutants,in
R4689 T7304 T7295 punct ", ",indicate
R4690 T7305 T7306 poss our,data
R4691 T7306 T7295 nsubj data,indicate
R4692 T7307 T7308 mark that,triggered
R4693 T7308 T7295 ccomp triggered,indicate
R4694 T7309 T7308 nsubjpass this,triggered
R4695 T7310 T7308 auxpass is,triggered
R4696 T7311 T7308 agent by,triggered
R4697 T7312 T7313 amod defective,repair
R4698 T7313 T7311 pobj repair,by
R4699 T7314 T7313 compound DSB,repair
R4700 T7315 T7316 advmod rather,than
R4701 T7316 T7313 prep than,repair
R4702 T7317 T7316 pobj asynapsis,than
R4703 T7318 T7295 punct .,indicate
R4704 T7320 T7321 nsubj We,base
R4705 T7321 T7322 ccomp base,is
R4706 T7323 T7324 det this,conclusion
R4707 T7324 T7321 dobj conclusion,base
R4708 T7325 T7324 prep on,conclusion
R4709 T7326 T7327 nummod two,observations
R4710 T7327 T7325 pobj observations,on
R4711 T7328 T7322 punct : ,is
R4712 T7329 T7330 punct (,1
R4713 T7330 T7322 meta 1,is
R4714 T7331 T7330 punct ),1
R4715 T7332 T7333 compound oocyte,elimination
R4716 T7333 T7322 nsubj elimination,is
R4717 T7334 T7322 acomp dependent,is
R4718 T7335 T7334 prep upon,dependent
R4719 T7336 T7337 compound DSB,formation
R4720 T7337 T7335 pobj formation,upon
R4721 T7338 T7322 cc and,is
R4722 T7339 T7340 punct (,2
R4723 T7340 T7341 meta 2,is
R4724 T7341 T7322 conj is,is
R4725 T7342 T7340 punct ),2
R4726 T7343 T7341 nsubj synapsis,is
R4727 T7344 T7341 acomp normal,is
R4728 T7345 T7341 prep in,is
R4729 T7346 T7345 pobj spermatocytes,in
R4730 T7347 T7346 prep of,spermatocytes
R4731 T7348 T7349 amod adult,testes
R4732 T7349 T7347 pobj testes,of
R4733 T7350 T7322 punct .,is
R4734 T7352 T7353 advmod Indeed,is
R4735 T7354 T7353 punct ", ",is
R4736 T7355 T7356 det this,mutant
R4737 T7356 T7353 nsubj mutant,is
R4738 T7357 T7353 acomp unique,is
R4739 T7358 T7359 mark in,occur
R4740 T7359 T7353 advcl occur,is
R4741 T7360 T7359 mark that,occur
R4742 T7361 T7362 compound recombination,defects
R4743 T7362 T7359 nsubj defects,occur
R4744 T7363 T7359 prep in,occur
R4745 T7364 T7365 det the,absence
R4746 T7365 T7363 pobj absence,in
R4747 T7366 T7365 prep of,absence
R4748 T7367 T7366 pobj asynapsis,of
R4749 T7368 T7369 punct (,as
R4750 T7369 T7359 parataxis as,occur
R4751 T7370 T7369 advmod e.g.,as
R4752 T7371 T7369 punct ", ",as
R4753 T7372 T7369 prep in,as
R4754 T7373 T7374 compound Dmc1,knockouts
R4755 T7374 T7372 pobj knockouts,in
R4756 T7375 T7369 punct ),as
R4757 T7376 T7353 punct .,is
R4758 T7378 T7379 advmod Thus,provides
R4759 T7380 T7379 punct ", ",provides
R4760 T7381 T7382 det the,mutant
R4761 T7382 T7379 nsubj mutant,provides
R4762 T7383 T7382 compound Trip13,mutant
R4763 T7384 T7385 det the,evidence
R4764 T7385 T7379 dobj evidence,provides
R4765 T7386 T7385 amod first,evidence
R4766 T7387 T7388 mark that,trigger
R4767 T7388 T7385 acl trigger,evidence
R4768 T7389 T7390 amod unrepaired,damage
R4769 T7390 T7388 nsubj damage,trigger
R4770 T7391 T7390 compound DNA,damage
R4771 T7392 T7390 advmod alone,damage
R4772 T7393 T7388 aux can,trigger
R4773 T7394 T7395 det the,response
R4774 T7395 T7388 dobj response,trigger
R4775 T7396 T7395 amod mammalian,response
R4776 T7397 T7398 compound pachytene,checkpoint
R4777 T7398 T7395 compound checkpoint,response
R4778 T7399 T7379 punct .,provides
R4779 T7401 T7402 advmod Furthermore,allow
R4780 T7403 T7402 punct ", ",allow
R4781 T7404 T7405 poss our,results
R4782 T7405 T7402 nsubj results,allow
R4783 T7406 T7407 nsubj us,conclude
R4784 T7407 T7402 ccomp conclude,allow
R4785 T7408 T7407 aux to,conclude
R4786 T7409 T7410 mark that,share
R4787 T7410 T7407 ccomp share,conclude
R4788 T7411 T7410 nsubj oocytes,share
R4789 T7412 T7411 cc and,oocytes
R4790 T7413 T7411 conj spermatocytes,oocytes
R4791 T7414 T7415 det a,checkpoint
R4792 T7415 T7410 dobj checkpoint,share
R4793 T7416 T7415 amod similar,checkpoint
R4794 T7417 T7416 punct ", ",similar
R4795 T7418 T7416 cc if,similar
R4796 T7419 T7418 neg not,if
R4797 T7420 T7416 conj identical,similar
R4798 T7421 T7415 punct ", ",checkpoint
R4799 T7422 T7423 compound DNA,damage
R4800 T7423 T7415 compound damage,checkpoint
R4801 T7424 T7415 compound pachytene,checkpoint
R4802 T7425 T7426 dep that,decoupled
R4803 T7426 T7415 relcl decoupled,checkpoint
R4804 T7427 T7426 auxpass is,decoupled
R4805 T7428 T7426 prep from,decoupled
R4806 T7429 T7430 det a,checkpoint
R4807 T7430 T7428 pobj checkpoint,from
R4808 T7431 T7430 compound synapsis,checkpoint
R4809 T7432 T7402 punct .,allow
R4810 T7434 T7435 advmod Interestingly,found
R4811 T7436 T7435 punct ", ",found
R4812 T7437 T7435 nsubj we,found
R4813 T7438 T7439 mark that,propel
R4814 T7439 T7435 ccomp propel,found
R4815 T7440 T7441 compound OA,treatment
R4816 T7441 T7439 nsubj treatment,propel
R4817 T7442 T7441 prep of,treatment
R4818 T7443 T7444 compound Trip13Gt,Gt
R4819 T7444 T7446 compound Gt,spermatocytes
R4820 T7445 T7444 punct /,Gt
R4821 T7446 T7442 pobj spermatocytes,of
R4822 T7447 T7439 aux could,propel
R4823 T7448 T7439 dobj them,propel
R4824 T7449 T7439 prep into,propel
R4825 T7450 T7449 pobj MI,into
R4826 T7451 T7439 punct ", ",propel
R4827 T7452 T7439 prep despite,propel
R4828 T7453 T7454 det a,report
R4829 T7454 T7452 pobj report,despite
R4830 T7455 T7456 mark that,occur
R4831 T7456 T7454 acl occur,report
R4832 T7457 T7458 det the,same
R4833 T7458 T7456 nsubj same,occur
R4834 T7459 T7456 aux did,occur
R4835 T7460 T7456 neg not,occur
R4836 T7461 T7462 advmod when,treated
R4837 T7462 T7456 advcl treated,occur
R4838 T7463 T7464 amod wild,type
R4839 T7464 T7466 compound type,spermatocytes
R4840 T7465 T7464 punct -,type
R4841 T7466 T7462 nsubjpass spermatocytes,treated
R4842 T7467 T7466 compound pachytene,spermatocytes
R4843 T7468 T7462 auxpass were,treated
R4844 T7469 T7462 prep with,treated
R4845 T7470 T7471 det the,agents
R4846 T7471 T7469 pobj agents,with
R4847 T7472 T7473 npadvmod DSB,inducing
R4848 T7473 T7471 amod inducing,agents
R4849 T7474 T7473 punct -,inducing
R4850 T7475 T7476 compound gamma,radiation
R4851 T7476 T7471 appos radiation,agents
R4852 T7477 T7476 cc or,radiation
R4853 T7478 T7476 conj etoposide,radiation
R4854 T7479 T7480 punct [,53
R4855 T7480 T7435 parataxis 53,found
R4856 T7481 T7480 punct ],53
R4857 T7482 T7435 punct .,found
R4858 T7484 T7485 nsubj It,is
R4859 T7486 T7485 acomp possible,is
R4860 T7487 T7488 mark that,evokes
R4861 T7488 T7485 ccomp evokes,is
R4862 T7489 T7490 det the,induction
R4863 T7490 T7488 nsubj induction,evokes
R4864 T7491 T7490 amod nascent,induction
R4865 T7492 T7490 prep of,induction
R4866 T7493 T7492 pobj DSBs,of
R4867 T7494 T7490 prep in,induction
R4868 T7495 T7494 pobj pachynema,in
R4869 T7496 T7497 det a,response
R4870 T7497 T7488 dobj response,evokes
R4871 T7498 T7497 compound checkpoint,response
R4872 T7499 T7500 dep that,bypassed
R4873 T7500 T7497 relcl bypassed,response
R4874 T7501 T7500 aux can,bypassed
R4875 T7502 T7500 neg not,bypassed
R4876 T7503 T7500 auxpass be,bypassed
R4877 T7504 T7500 agent by,bypassed
R4878 T7505 T7504 pobj OA,by
R4879 T7506 T7488 punct ", ",evokes
R4880 T7507 T7508 mark whereas,do
R4881 T7508 T7488 advcl do,evokes
R4882 T7509 T7510 det the,lesions
R4883 T7510 T7508 nsubj lesions,do
R4884 T7511 T7510 nmod post-strand,lesions
R4885 T7512 T7511 advmod invasion,post-strand
R4886 T7513 T7510 prep in,lesions
R4887 T7514 T7515 npadvmod TRIP13,deficient
R4888 T7515 T7517 amod deficient,spermatocytes
R4889 T7516 T7515 punct -,deficient
R4890 T7517 T7513 pobj spermatocytes,in
R4891 T7518 T7508 neg not,do
R4892 T7519 T7485 punct .,is
R4893 T7521 T7522 nsubjpass TRIP13,discovered
R4894 T7523 T7522 auxpass was,discovered
R4895 T7524 T7522 advmod originally,discovered
R4896 T7525 T7526 aux to,be
R4897 T7526 T7522 xcomp be,discovered
R4898 T7527 T7528 det an,interactor
R4899 T7528 T7526 attr interactor,be
R4900 T7529 T7528 prep with,interactor
R4901 T7530 T7531 compound rat,beta
R4902 T7531 T7529 pobj beta,with
R4903 T7532 T7531 compound thyroid,beta
R4904 T7533 T7531 compound receptor,beta
R4905 T7534 T7531 punct (,beta
R4906 T7535 T7531 appos THRB,beta
R4907 T7536 T7526 punct ;,be
R4908 T7537 T7538 punct [,54
R4909 T7538 T7526 parataxis 54,be
R4910 T7539 T7538 punct ],54
R4911 T7540 T7522 punct ),discovered
R4912 T7541 T7522 punct ", ",discovered
R4913 T7542 T7522 cc but,discovered
R4914 T7543 T7544 det the,relationship
R4915 T7544 T7545 nsubj relationship,is
R4916 T7545 T7522 conj is,discovered
R4917 T7546 T7544 prep between,relationship
R4918 T7547 T7546 pobj THRB,between
R4919 T7548 T7547 cc and,THRB
R4920 T7549 T7547 conj TRIP13,THRB
R4921 T7550 T7544 prep in,relationship
R4922 T7551 T7550 pobj meiosis,in
R4923 T7552 T7545 acomp unknown,is
R4924 T7553 T7545 punct .,is
R4925 T7555 T7556 advmod Interestingly,observed
R4926 T7557 T7556 punct ", ",observed
R4927 T7558 T7556 nsubj we,observed
R4928 T7559 T7560 mark that,distributed
R4929 T7560 T7556 ccomp distributed,observed
R4930 T7561 T7560 nsubjpass THRB,distributed
R4931 T7562 T7560 auxpass is,distributed
R4932 T7563 T7560 advmod diffusely,distributed
R4933 T7564 T7560 prep throughout,distributed
R4934 T7565 T7566 amod wild,type
R4935 T7566 T7568 compound type,nuclei
R4936 T7567 T7566 punct -,type
R4937 T7568 T7564 pobj nuclei,throughout
R4938 T7569 T7568 compound spermatocyte,nuclei
R4939 T7570 T7560 cc but,distributed
R4940 T7571 T7572 auxpass is,excluded
R4941 T7572 T7560 conj excluded,distributed
R4942 T7573 T7572 prep from,excluded
R4943 T7574 T7575 det the,body
R4944 T7575 T7573 pobj body,from
R4945 T7576 T7575 nmod XY,body
R4946 T7577 T7578 punct (,sex
R4947 T7578 T7575 parataxis sex,body
R4948 T7579 T7578 punct ),sex
R4949 T7580 T7581 punct (,observations
R4950 T7581 T7575 meta observations,body
R4951 T7582 T7581 amod unpublished,observations
R4952 T7583 T7581 punct ),observations
R4953 T7584 T7575 punct ", ",body
R4954 T7585 T7586 det a,domain
R4955 T7586 T7575 appos domain,body
R4956 T7587 T7586 amod compartmentalized,domain
R4957 T7588 T7586 amod nuclear,domain
R4958 T7589 T7586 acl beginning,domain
R4959 T7590 T7589 prep in,beginning
R4960 T7591 T7590 pobj pachynema,in
R4961 T7592 T7591 punct ", ",pachynema
R4962 T7593 T7594 prep in,become
R4963 T7594 T7591 relcl become,pachynema
R4964 T7595 T7593 pobj which,in
R4965 T7596 T7597 det the,chromosomes
R4966 T7597 T7594 nsubj chromosomes,become
R4967 T7598 T7597 compound sex,chromosomes
R4968 T7599 T7594 acomp heterochromatinized,become
R4969 T7600 T7599 cc and,heterochromatinized
R4970 T7601 T7602 advmod transcriptionally,silenced
R4971 T7602 T7599 conj silenced,heterochromatinized
R4972 T7603 T7594 prep in,become
R4973 T7604 T7605 det the,process
R4974 T7605 T7603 pobj process,in
R4975 T7606 T7605 prep of,process
R4976 T7607 T7606 pobj MSCI,of
R4977 T7608 T7609 punct [,55
R4978 T7609 T7572 parataxis 55,excluded
R4979 T7610 T7609 punct ],55
R4980 T7611 T7556 punct .,observed
R4981 T7613 T7614 advmod However,appeared
R4982 T7615 T7614 punct ", ",appeared
R4983 T7616 T7617 det the,body
R4984 T7617 T7614 nsubj body,appeared
R4985 T7618 T7617 compound XY,body
R4986 T7619 T7614 oprd intact,appeared
R4987 T7620 T7614 prep in,appeared
R4988 T7621 T7622 amod most,spermatocytes
R4989 T7622 T7620 pobj spermatocytes,in
R4990 T7623 T7622 compound mutant,spermatocytes
R4991 T7624 T7614 prep upon,appeared
R4992 T7625 T7624 pcomp probing,upon
R4993 T7626 T7625 prep with,probing
R4994 T7627 T7628 amod several,markers
R4995 T7628 T7626 pobj markers,with
R4996 T7629 T7628 prep of,markers
R4997 T7630 T7631 compound XY,heterochromatinization
R4998 T7631 T7629 pobj heterochromatinization,of
R4999 T7632 T7633 punct (,observations
R5000 T7633 T7614 meta observations,appeared
R5001 T7634 T7633 amod unpublished,observations
R5002 T7635 T7633 punct ),observations
R5003 T7636 T7614 punct .,appeared
R5004 T7638 T7639 advcl Considering,is
R5005 T7640 T7641 mark that,are
R5006 T7641 T7638 ccomp are,Considering
R5007 T7642 T7643 compound THRB,knockout
R5008 T7643 T7644 compound knockout,mice
R5009 T7644 T7641 nsubj mice,are
R5010 T7645 T7641 acomp viable,are
R5011 T7646 T7645 cc and,viable
R5012 T7647 T7645 conj fertile,viable
R5013 T7648 T7649 punct [,56
R5014 T7649 T7641 parataxis 56,are
R5015 T7650 T7649 punct ],56
R5016 T7651 T7639 punct ", ",is
R5017 T7652 T7653 det the,relationship
R5018 T7653 T7639 nsubj relationship,is
R5019 T7654 T7653 amod functional,relationship
R5020 T7655 T7653 prep between,relationship
R5021 T7656 T7655 pobj TRIP13,between
R5022 T7657 T7656 cc and,TRIP13
R5023 T7658 T7659 poss its,receptor
R5024 T7659 T7656 conj receptor,TRIP13
R5025 T7660 T7659 appos THRB,receptor
R5026 T7661 T7653 prep in,relationship
R5027 T7662 T7661 pobj meiosis,in
R5028 T7663 T7639 acomp unclear,is
R5029 T7664 T7639 punct .,is
R5030 T7666 T7667 prep Given,conserved
R5031 T7668 T7669 det the,similarity
R5032 T7669 T7666 pobj similarity,Given
R5033 T7670 T7669 amod high,similarity
R5034 T7671 T7669 prep of,similarity
R5035 T7672 T7673 compound PCH2,orthologs
R5036 T7673 T7671 pobj orthologs,of
R5037 T7674 T7669 prep throughout,similarity
R5038 T7675 T7676 det the,world
R5039 T7676 T7674 pobj world,throughout
R5040 T7677 T7676 amod eukaryotic,world
R5041 T7678 T7667 punct ", ",conserved
R5042 T7679 T7680 nummod one,functions
R5043 T7680 T7667 nsubjpass functions,conserved
R5044 T7681 T7679 cc or,one
R5045 T7682 T7679 conj more,one
R5046 T7683 T7680 amod essential,functions
R5047 T7684 T7680 prep of,functions
R5048 T7685 T7686 det this,protein
R5049 T7686 T7684 pobj protein,of
R5050 T7687 T7667 aux must,conserved
R5051 T7688 T7667 auxpass be,conserved
R5052 T7689 T7667 punct .,conserved
R5053 T7691 T7692 mark Since,exhibit
R5054 T7692 T7696 advcl exhibit,surmise
R5055 T7693 T7692 nsubj TRIP13,exhibit
R5056 T7694 T7692 aux does,exhibit
R5057 T7695 T7692 neg not,exhibit
R5058 T7697 T7698 compound checkpoint,function
R5059 T7698 T7692 dobj function,exhibit
R5060 T7699 T7692 prep in,exhibit
R5061 T7700 T7699 pobj mice,in
R5062 T7701 T7696 punct ", ",surmise
R5063 T7702 T7696 nsubj we,surmise
R5064 T7703 T7704 mark that,had
R5065 T7704 T7696 ccomp had,surmise
R5066 T7705 T7706 det the,protein
R5067 T7706 T7704 nsubj protein,had
R5068 T7707 T7708 nmod TRIP13,PCH2
R5069 T7708 T7706 nmod PCH2,protein
R5070 T7709 T7708 punct /,PCH2
R5071 T7710 T7706 amod ancestral,protein
R5072 T7711 T7712 det a,function
R5073 T7712 T7704 dobj function,had
R5074 T7713 T7712 prep in,function
R5075 T7714 T7713 pobj recombination,in
R5076 T7715 T7716 dep that,persists
R5077 T7716 T7712 relcl persists,function
R5078 T7717 T7716 prep to,persists
R5079 T7718 T7719 det the,present
R5080 T7719 T7717 pobj present,to
R5081 T7720 T7696 punct .,surmise
R5082 T7722 T7723 advmod Notably,appear
R5083 T7724 T7723 punct ", ",appear
R5084 T7725 T7726 compound A.,thaliana
R5085 T7726 T7723 nsubj thaliana,appear
R5086 T7727 T7723 aux does,appear
R5087 T7728 T7723 neg not,appear
R5088 T7729 T7730 aux to,have
R5089 T7730 T7723 xcomp have,appear
R5090 T7731 T7732 det a,activity
R5091 T7732 T7730 dobj activity,have
R5092 T7733 T7734 amod meiotic,checkpoint
R5093 T7734 T7732 compound checkpoint,activity
R5094 T7735 T7736 dep that,eliminates
R5095 T7736 T7732 relcl eliminates,activity
R5096 T7737 T7738 compound mutant,meiocytes
R5097 T7738 T7736 dobj meiocytes,eliminates
R5098 T7739 T7736 prep in,eliminates
R5099 T7740 T7741 det a,manner
R5100 T7741 T7739 pobj manner,in
R5101 T7742 T7741 amod analogous,manner
R5102 T7743 T7742 prep to,analogous
R5103 T7744 T7743 pobj organisms,to
R5104 T7745 T7746 amod such,as
R5105 T7746 T7744 prep as,organisms
R5106 T7747 T7746 pobj mice,as
R5107 T7748 T7747 punct ", ",mice
R5108 T7749 T7750 amod budding,yeast
R5109 T7750 T7747 conj yeast,mice
R5110 T7759 T7756 punct ],57
R5111 T7751 T7750 punct ", ",yeast
R5112 T7760 T7723 punct ", ",appear
R5113 T7752 T7750 cc and,yeast
R5114 T7761 T7723 cc and,appear
R5115 T7762 T7763 amod mammalian,TRIP13
R5116 T7753 T7754 amod female,Drosophila
R5117 T7763 T7764 nsubj TRIP13,is
R5118 T7764 T7723 conj is,appear
R5119 T7754 T7750 conj Drosophila,yeast
R5120 T7765 T7766 advmod more,similar
R5121 T7766 T7764 acomp similar,is
R5122 T7755 T7756 punct [,57
R5123 T7767 T7766 prep to,similar
R5124 T7756 T7723 parataxis 57,appear
R5125 T7768 T7769 compound Arabidopsis,PCH2
R5126 T7769 T7767 pobj PCH2,to
R5127 T7757 T7756 nummod 11,57
R5128 T7770 T7766 prep than,similar
R5129 T7771 T7772 det the,proteins
R5130 T7772 T7770 pobj proteins,than
R5131 T7773 T7772 nmod fly,proteins
R5132 T7758 T7756 punct ",",57
R5133 T7774 T7773 cc or,fly
R5134 T7775 T7773 conj worm,fly
R5135 T7865 T7863 nsubjpass functions,gained
R5136 T7776 T7777 punct (,1A
R5137 T7777 T7764 parataxis 1A,is
R5138 T7778 T7777 compound Figures,1A
R5139 T7779 T7777 cc and,1A
R5140 T7780 T7777 conj S1,1A
R5141 T7781 T7777 punct ),1A
R5142 T7866 T7865 prep in,functions
R5143 T7782 T7723 punct .,appear
R5144 T7867 T7866 pobj PCH2,in
R5145 T7784 T7785 det The,relatedness
R5146 T7785 T7787 nsubj relatedness,be
R5147 T7786 T7785 amod unusual,relatedness
R5148 T7868 T7863 auxpass were,gained
R5149 T7788 T7785 prep between,relatedness
R5150 T7869 T7863 cc or,gained
R5151 T7789 T7790 amod mammalian,PCH2
R5152 T7790 T7788 pobj PCH2,between
R5153 T7870 T7863 conj lost,gained
R5154 T7791 T7789 cc and,mammalian
R5155 T7792 T7789 conj plant,mammalian
R5156 T7793 T7787 aux may,be
R5157 T7871 T7832 punct .,allow
R5158 T7794 T7787 advmod therefore,be
R5159 T7795 T7787 acomp attributable,be
R5160 T7796 T7795 prep to,attributable
R5161 T7873 T7874 nsubj It,is
R5162 T7797 T7798 preconj both,presence
R5163 T7798 T7796 pobj presence,to
R5164 T7799 T7798 det the,presence
R5165 T7875 T7874 acomp possible,is
R5166 T7800 T7798 prep of,presence
R5167 T7801 T7802 det a,function
R5168 T7802 T7800 pobj function,of
R5169 T7803 T7802 amod common,function
R5170 T7804 T7802 amod conserved,function
R5171 T7876 T7877 mark that,evolved
R5172 T7805 T7806 punct (,recombination
R5173 T7806 T7802 parataxis recombination,function
R5174 T7877 T7874 ccomp evolved,is
R5175 T7807 T7806 advmod namely,recombination
R5176 T7808 T7806 punct ", ",recombination
R5177 T7809 T7810 mark although,has
R5178 T7878 T7879 poss its,function
R5179 T7810 T7806 advcl has,recombination
R5180 T7811 T7812 det the,role
R5181 T7812 T7810 nsubj role,has
R5182 T7813 T7812 prep of,role
R5183 T7814 T7813 pobj PCH2,of
R5184 T7879 T7877 nsubj function,evolved
R5185 T7815 T7812 prep in,role
R5186 T7816 T7815 pobj plants,in
R5187 T7817 T7818 advmod yet,determined
R5188 T7880 T7879 compound checkpoint,function
R5189 T7818 T7810 xcomp determined,has
R5190 T7819 T7818 aux to,determined
R5191 T7820 T7818 auxpass be,determined
R5192 T7881 T7877 advmod independently,evolved
R5193 T7821 T7810 punct ),has
R5194 T7822 T7798 punct ", ",presence
R5195 T7882 T7877 prep in,evolved
R5196 T7823 T7798 cc and,presence
R5197 T7824 T7825 det the,absence
R5198 T7883 T7882 pobj worms,in
R5199 T7825 T7798 conj absence,presence
R5200 T7826 T7825 prep of,absence
R5201 T7884 T7883 cc and,worms
R5202 T7885 T7886 compound budding,yeast
R5203 T7886 T7883 conj yeast,worms
R5204 T7887 T7874 punct .,is
R5205 T7827 T7828 compound checkpoint,function
R5206 T7889 T7890 det The,picture
R5207 T7828 T7826 pobj function,of
R5208 T7829 T7787 punct .,be
R5209 T7890 T7891 nsubj picture,become
R5210 T7831 T7832 advmod Nevertheless,allow
R5211 T7892 T7891 aux will,become
R5212 T7833 T7832 punct ", ",allow
R5213 T7834 T7835 det the,relationships
R5214 T7835 T7832 nsubj relationships,allow
R5215 T7893 T7891 acomp clearer,become
R5216 T7836 T7835 amod evolutionary,relationships
R5217 T7837 T7835 prep between,relationships
R5218 T7838 T7837 pobj animals,between
R5219 T7894 T7895 mark as,elucidated
R5220 T7839 T7838 punct ", ",animals
R5221 T7840 T7838 conj fungi,animals
R5222 T7895 T7891 advcl elucidated,become
R5223 T7841 T7840 punct ", ",fungi
R5224 T7842 T7840 cc and,fungi
R5225 T7843 T7840 conj plants,fungi
R5226 T7844 T7835 punct (,relationships
R5227 T7896 T7897 det the,function
R5228 T7845 T7846 dep which,are
R5229 T7846 T7835 relcl are,relationships
R5230 T7847 T7846 acomp discordant,are
R5231 T7897 T7895 nsubjpass function,elucidated
R5232 T7848 T7847 prep with,discordant
R5233 T7849 T7850 compound PCH2,phylogeny
R5234 T7898 T7897 prep of,function
R5235 T7850 T7848 pobj phylogeny,with
R5236 T7899 T7898 pobj PCH2,of
R5237 T7851 T7850 compound sequence,phylogeny
R5238 T7852 T7832 punct ),allow
R5239 T7900 T7897 prep in,function
R5240 T7853 T7832 aux do,allow
R5241 T7854 T7832 neg not,allow
R5242 T7855 T7856 amod parsimonious,models
R5243 T7901 T7902 amod other,organisms
R5244 T7856 T7832 dobj models,allow
R5245 T7857 T7856 acl addressing,models
R5246 T7902 T7900 pobj organisms,in
R5247 T7858 T7859 det the,points
R5248 T7859 T7857 dobj points,addressing
R5249 T7903 T7895 auxpass is,elucidated
R5250 T7860 T7859 prep in,points
R5251 T7861 T7860 pobj time,in
R5252 T7904 T7891 punct .,become
R5253 T7862 T7863 prep that,gained
R5254 T7863 T7861 relcl gained,time
R5255 T7864 T7865 compound checkpoint,functions
R5256 T7906 T7907 det The,nature
R5257 T7907 T7908 nsubj nature,remains
R5258 T7909 T7907 prep of,nature
R5259 T7910 T7911 det the,checkpoint
R5260 T7971 T7970 prep of,upstream
R5261 T7911 T7909 pobj checkpoint,of
R5262 T7972 T7971 pobj PCH2,of
R5263 T7973 T7967 punct .,acts
R5264 T7912 T7911 compound synapsis,checkpoint
R5265 T7975 T7976 prep Given,is
R5266 T7977 T7978 mark that,have
R5267 T7913 T7911 prep in,checkpoint
R5268 T7978 T7975 pcomp have,Given
R5269 T7979 T7978 nsubj TRIP13,have
R5270 T7914 T7915 amod male,mice
R5271 T7980 T7978 aux does,have
R5272 T7981 T7978 neg n't,have
R5273 T7915 T7913 pobj mice,in
R5274 T7982 T7983 compound checkpoint,function
R5275 T7983 T7978 dobj function,have
R5276 T7984 T7978 prep in,have
R5277 T7916 T7908 acomp unidentified,remains
R5278 T7985 T7984 pobj mice,in
R5279 T7986 T7976 punct ", ",is
R5280 T7917 T7908 punct .,remains
R5281 T7987 T7988 det a,role
R5282 T7988 T7976 nsubj role,is
R5283 T7989 T7988 amod potential,role
R5284 T7919 T7920 nummod One,candidate
R5285 T7990 T7988 prep for,role
R5286 T7920 T7922 nsubj candidate,is
R5287 T7991 T7992 amod mammalian,DOT1
R5288 T7921 T7920 amod possible,candidate
R5289 T7992 T7990 pobj DOT1,for
R5290 T7993 T7988 prep in,role
R5291 T7923 T7922 attr Dot1,is
R5292 T7994 T7995 det the,checkpoint
R5293 T7995 T7993 pobj checkpoint,in
R5294 T7996 T7995 compound pachytene,checkpoint
R5295 T7924 T7923 punct (,Dot1
R5296 T7997 T7976 acomp dubious,is
R5297 T7998 T7976 cc but,is
R5298 T7999 T7976 conj awaits,is
R5299 T7925 T7923 appos PCH1,Dot1
R5300 T8000 T7999 dobj investigation,awaits
R5301 T8001 T7976 punct .,is
R5302 T7926 T7925 prep in,PCH1
R5303 T8003 T8004 advmod Recently,shown
R5304 T7927 T7926 pobj yeast,in
R5305 T8005 T8004 punct ", ",shown
R5306 T7928 T7923 punct ),Dot1
R5307 T8006 T8004 nsubjpass it,shown
R5308 T8007 T8004 auxpass was,shown
R5309 T8008 T8009 mark that,required
R5310 T7929 T7923 punct ", ",Dot1
R5311 T8009 T8004 ccomp required,shown
R5312 T8010 T8011 det the,homolog
R5313 T8011 T8009 nsubjpass homolog,required
R5314 T7930 T7931 det a,factor
R5315 T8012 T8011 compound TRP53,homolog
R5316 T8013 T8011 appos TRP63,homolog
R5317 T7931 T7923 appos factor,Dot1
R5318 T8014 T8009 auxpass is,required
R5319 T8015 T8009 prep for,required
R5320 T8016 T8017 compound DNA,damage
R5321 T7932 T7933 compound histone,methyltransferase
R5322 T8017 T8018 npadvmod damage,induced
R5323 T8018 T8020 amod induced,death
R5324 T8019 T8018 punct –,induced
R5325 T7933 T7934 compound methyltransferase,silencing
R5326 T8020 T8015 pobj death,for
R5327 T7934 T7931 compound silencing,factor
R5328 T8021 T8020 prep of,death
R5329 T8022 T8023 nmod dictyate,stage
R5330 T8023 T8025 nmod stage,oocytes
R5331 T7935 T7936 dep that,required
R5332 T8024 T8023 punct -,stage
R5333 T7936 T7931 relcl required,factor
R5334 T8025 T8021 pobj oocytes,of
R5335 T7937 T7936 auxpass is,required
R5336 T8026 T8025 amod primordial,oocytes
R5337 T8027 T8009 punct ", ",required
R5338 T8028 T8009 advcl leading,required
R5339 T8029 T8028 prep to,leading
R5340 T8030 T8031 det the,suggestion
R5341 T7938 T7936 prep for,required
R5342 T7939 T7940 compound pachytene,arrest
R5343 T8031 T8029 pobj suggestion,to
R5344 T7940 T7938 pobj arrest,for
R5345 T8032 T8033 mark that,involved
R5346 T8033 T8031 acl involved,suggestion
R5347 T8034 T8033 nsubjpass it,involved
R5348 T7941 T7940 prep of,arrest
R5349 T8035 T8033 auxpass is,involved
R5350 T8036 T8033 prep in,involved
R5351 T8037 T8036 pcomp monitoring,in
R5352 T7942 T7943 nmod zip1,mutants
R5353 T8038 T8039 compound genome,integrity
R5354 T8039 T8037 dobj integrity,monitoring
R5355 T7943 T7941 pobj mutants,of
R5356 T8040 T8041 punct [,59
R5357 T8041 T8009 parataxis 59,required
R5358 T8042 T8041 punct ],59
R5359 T7944 T7942 cc and,zip1
R5360 T8043 T8004 punct .,shown
R5361 T7945 T7942 conj dmc1,zip1
R5362 T8045 T8046 advmod However,occurs
R5363 T8047 T8046 punct ", ",occurs
R5364 T7946 T7940 prep in,arrest
R5365 T8048 T8049 det this,activity
R5366 T8049 T8046 nsubj activity,occurs
R5367 T7947 T7946 pobj yeast,in
R5368 T8050 T8046 advmod subsequent,occurs
R5369 T8051 T8050 prep to,subsequent
R5370 T8052 T8053 det a,checkpoint
R5371 T7948 T7949 punct [,58
R5372 T8053 T8051 pobj checkpoint,to
R5373 T8054 T8053 compound pachytene,checkpoint
R5374 T7949 T7940 parataxis 58,arrest
R5375 T8055 T8046 punct .,occurs
R5376 T8057 T8058 mark As,alluded
R5377 T7950 T7949 punct ],58
R5378 T8058 T8059 advcl alluded,is
R5379 T8060 T8058 prep to,alluded
R5380 T7951 T7938 punct ", ",for
R5381 T8061 T8058 advmod earlier,alluded
R5382 T8062 T8059 punct ", ",is
R5383 T8063 T8064 det a,problem
R5384 T7952 T7938 cc and,for
R5385 T8064 T8059 nsubj problem,is
R5386 T8065 T8064 amod complicating,problem
R5387 T7953 T7938 conj for,for
R5388 T8066 T8064 prep for,problem
R5389 T8067 T8066 pcomp studying,for
R5390 T8068 T8069 amod potential,checkpoint
R5391 T8069 T8071 compound checkpoint,genes
R5392 T8070 T8069 amod meiotic,checkpoint
R5393 T8071 T8067 dobj genes,studying
R5394 T7954 T7953 pcomp preventing,for
R5395 T8072 T8067 prep in,studying
R5396 T8073 T8072 pobj mice,in
R5397 T8074 T8075 mark that,have
R5398 T7955 T7956 npadvmod RAD54,mediated
R5399 T8075 T8059 ccomp have,is
R5400 T8076 T8075 prep as,have
R5401 T7956 T7958 amod mediated,repair
R5402 T7957 T7956 punct -,mediated
R5403 T7958 T7954 dobj repair,preventing
R5404 T7959 T7960 amod recombinational,DSB
R5405 T8077 T8076 prep in,as
R5406 T7960 T7958 compound DSB,repair
R5407 T8078 T8077 pobj yeast,in
R5408 T8079 T8075 punct ", ",have
R5409 T7961 T7958 prep between,repair
R5410 T8080 T8081 amod such,genes
R5411 T8081 T8075 nsubj genes,have
R5412 T8082 T8075 advmod often,have
R5413 T7962 T7963 compound sister,chromatids
R5414 T8083 T8084 amod mitotic,functions
R5415 T8084 T8075 dobj functions,have
R5416 T7963 T7961 pobj chromatids,between
R5417 T8085 T8084 punct (,functions
R5418 T8086 T8087 amod such,as
R5419 T7964 T7922 punct .,is
R5420 T8087 T8084 prep as,functions
R5421 T8088 T8087 pobj RAD24,as
R5422 T7966 T7967 advmod However,acts
R5423 T8089 T8090 punct [,7
R5424 T8090 T8075 parataxis 7,have
R5425 T8091 T8090 punct ],7
R5426 T8092 T8059 punct ),is
R5427 T7968 T7967 punct ", ",acts
R5428 T8093 T8059 punct ", ",is
R5429 T8094 T8059 cc and,is
R5430 T8095 T8096 poss their,ablation
R5431 T8096 T8097 nsubj ablation,cause
R5432 T7969 T7967 nsubj DOT1,acts
R5433 T8097 T8059 conj cause,is
R5434 T8098 T8097 aux can,cause
R5435 T8099 T8097 dobj lethality,cause
R5436 T7970 T7967 advmod upstream,acts
R5437 T8100 T8101 punct [,42
R5438 T8101 T8097 parataxis 42,cause
R5439 T8102 T8101 punct ],42
R5440 T8103 T8097 punct .,cause
R5441 T8105 T8106 mark Unless,have
R5442 T8106 T8111 advcl have,are
R5443 T8107 T8108 amod mammalian,components
R5444 T8108 T8106 nsubj components,have
R5445 T8109 T8110 compound pachytene,checkpoint
R5446 T8110 T8108 compound checkpoint,components
R5447 T8112 T8106 dobj orthologs,have
R5448 T8113 T8112 prep with,orthologs
R5449 T8114 T8115 amod similar,functions
R5450 T8115 T8113 pobj functions,with
R5451 T8116 T8106 prep in,have
R5452 T8117 T8116 pobj organisms,in
R5453 T8118 T8119 amod such,as
R5454 T8119 T8117 prep as,organisms
R5455 T8120 T8119 pobj yeast,as
R5456 T8121 T8111 punct ", ",are
R5457 T8122 T8123 poss their,identities
R5458 T8123 T8111 nsubj identities,are
R5459 T8124 T8111 acomp likely,are
R5460 T8125 T8126 aux to,remain
R5461 T8126 T8124 xcomp remain,likely
R5462 T8127 T8126 acomp elusive,remain
R5463 T8128 T8111 punct .,are
R5464 T8150 T8151 compound PCR,analysis
R5465 T8152 T8151 prep of,analysis
R5466 T8153 T8154 compound Trip13,cDNA
R5467 T8154 T8152 pobj cDNA,of
R5468 T8155 T8151 punct .,analysis
R5469 T8157 T8158 nsubjpass Trip13,amplified
R5470 T8159 T8158 auxpass was,amplified
R5471 T8160 T8158 prep from,amplified
R5472 T8161 T8160 pobj samples,from
R5473 T8162 T8161 prep of,samples
R5474 T8163 T8164 poss Clontech,Panel
R5475 T8164 T8162 pobj Panel,of
R5476 T8165 T8163 case 's,Clontech
R5477 T8166 T8164 nmod Mouse,Panel
R5478 T8167 T8168 amod Multiple,Tissue
R5479 T8168 T8164 compound Tissue,Panel
R5480 T8169 T8164 compound cDNA,Panel
R5481 T8170 T8164 nummod I,Panel
R5482 T8171 T8172 punct (,http://www.clontech.com
R5483 T8172 T8161 parataxis http://www.clontech.com,samples
R5484 T8173 T8172 punct ),http://www.clontech.com
R5485 T8174 T8158 punct ", ",amplified
R5486 T8175 T8158 advcl using,amplified
R5487 T8176 T8177 det the,primers
R5488 T8177 T8175 dobj primers,using
R5489 T8178 T8177 amod following,primers
R5490 T8179 T8177 punct : ,primers
R5491 T8180 T8181 nummod 5,GCACCATTGCACTTCACATC
R5492 T8181 T8177 appos GCACCATTGCACTTCACATC,primers
R5493 T8182 T8180 punct ′,5
R5494 T8183 T8181 punct -,GCACCATTGCACTTCACATC
R5495 T8184 T8181 punct -,GCACCATTGCACTTCACATC
R5496 T8185 T8181 nummod 3,GCACCATTGCACTTCACATC
R5497 T8186 T8181 punct ′,GCACCATTGCACTTCACATC
R5498 T8187 T8181 punct (,GCACCATTGCACTTCACATC
R5499 T8188 T8189 compound TRP3,6F
R5500 T8189 T8181 appos 6F,GCACCATTGCACTTCACATC
R5501 T8190 T8189 punct -,6F
R5502 T8191 T8181 punct ),GCACCATTGCACTTCACATC
R5503 T8192 T8181 cc and,GCACCATTGCACTTCACATC
R5504 T8193 T8194 nummod 5,TGACCATCAGACTGTCGAGC
R5505 T8194 T8181 conj TGACCATCAGACTGTCGAGC,GCACCATTGCACTTCACATC
R5506 T8195 T8193 punct ′,5
R5507 T8196 T8194 punct -,TGACCATCAGACTGTCGAGC
R5508 T8197 T8194 punct -,TGACCATCAGACTGTCGAGC
R5509 T8198 T8194 nummod 3,TGACCATCAGACTGTCGAGC
R5510 T8199 T8194 punct ′,TGACCATCAGACTGTCGAGC
R5511 T8200 T8194 punct (,TGACCATCAGACTGTCGAGC
R5512 T8201 T8202 compound TRP3,6R
R5513 T8202 T8194 appos 6R,TGACCATCAGACTGTCGAGC
R5514 T8203 T8202 punct -,6R
R5515 T8204 T8158 punct ),amplified
R5516 T8205 T8158 punct .,amplified
R5517 T8207 T8208 det These,primers
R5518 T8208 T8209 nsubj primers,correspond
R5519 T8210 T8209 prep to,correspond
R5520 T8211 T8212 nmod exons,3
R5521 T8212 T8210 pobj 3,to
R5522 T8213 T8212 cc and,3
R5523 T8214 T8212 conj 6,3
R5524 T8215 T8209 punct ", ",correspond
R5525 T8216 T8209 advmod respectively,correspond
R5526 T8217 T8209 punct ", ",correspond
R5527 T8218 T8209 cc and,correspond
R5528 T8219 T8209 conj amplify,correspond
R5529 T8220 T8221 det a,product
R5530 T8221 T8219 dobj product,amplify
R5531 T8222 T8223 nummod 330,bp
R5532 T8223 T8221 compound bp,product
R5533 T8224 T8223 punct -,bp
R5534 T8225 T8221 compound cDNA,product
R5535 T8226 T8209 punct .,correspond
R5536 T8228 T8229 det The,cDNAs
R5537 T8229 T8230 nsubjpass cDNAs,equalized
R5538 T8231 T8229 prep in,cDNAs
R5539 T8232 T8233 det this,panel
R5540 T8233 T8231 pobj panel,in
R5541 T8234 T8230 auxpass are,equalized
R5542 T8235 T8236 aux to,allow
R5543 T8236 T8230 advcl allow,equalized
R5544 T8237 T8238 amod quantitative,analysis
R5545 T8238 T8236 dobj analysis,allow
R5546 T8239 T8238 prep by,analysis
R5547 T8240 T8241 compound RT,PCR
R5548 T8241 T8239 pobj PCR,by
R5549 T8242 T8241 punct -,PCR
R5550 T8243 T8230 punct .,equalized
R5551 T8309 T8308 prep of,Generation
R5552 T8310 T8311 npadvmod Trip13,deficient
R5553 T8311 T8313 amod deficient,mice
R5554 T8312 T8311 punct -,deficient
R5555 T8313 T8309 pobj mice,of
R5556 T8314 T8308 punct .,Generation
R5557 T8316 T8317 det The,RRB047
R5558 T8317 T8323 nsubjpass RRB047,obtained
R5559 T8318 T8317 nmod mouse,RRB047
R5560 T8319 T8317 amod embryonic,RRB047
R5561 T8320 T8321 compound stem,cell
R5562 T8321 T8317 compound cell,RRB047
R5563 T8322 T8317 compound line,RRB047
R5564 T8324 T8317 punct (,RRB047
R5565 T8325 T8326 nmod strain,Ola
R5566 T8326 T8317 appos Ola,RRB047
R5567 T8327 T8326 nummod 129,Ola
R5568 T8328 T8326 punct /,Ola
R5569 T8329 T8317 punct ),RRB047
R5570 T8330 T8317 acl containing,RRB047
R5571 T8331 T8332 det a,insertion
R5572 T8332 T8330 dobj insertion,containing
R5573 T8333 T8334 compound gene,trap
R5574 T8334 T8332 compound trap,insertion
R5575 T8335 T8330 prep in,containing
R5576 T8336 T8335 pobj Trip13,in
R5577 T8337 T8323 auxpass was,obtained
R5578 T8338 T8323 prep from,obtained
R5579 T8339 T8338 pobj BayGenomics,from
R5580 T8340 T8341 punct (,http://www.baygenomics.ucsf.edu/
R5581 T8341 T8339 parataxis http://www.baygenomics.ucsf.edu/,BayGenomics
R5582 T8342 T8341 punct ),http://www.baygenomics.ucsf.edu/
R5583 T8343 T8323 punct .,obtained
R5584 T8345 T8346 det The,vector
R5585 T8346 T8350 nsubjpass vector,designed
R5586 T8347 T8346 nmod gene,vector
R5587 T8348 T8347 punct -,gene
R5588 T8349 T8347 amod trapping,gene
R5589 T8351 T8346 acl used,vector
R5590 T8352 T8353 aux to,create
R5591 T8353 T8351 advcl create,used
R5592 T8354 T8355 det this,line
R5593 T8355 T8353 dobj line,create
R5594 T8356 T8346 punct ", ",vector
R5595 T8357 T8346 appos pGT1lxf,vector
R5596 T8358 T8350 punct ", ",designed
R5597 T8359 T8350 auxpass was,designed
R5598 T8360 T8361 aux to,create
R5599 T8361 T8350 advcl create,designed
R5600 T8362 T8363 det an,fusion
R5601 T8363 T8361 dobj fusion,create
R5602 T8364 T8363 nmod in,fusion
R5603 T8365 T8364 punct -,in
R5604 T8366 T8364 pobj frame,in
R5605 T8367 T8363 prep between,fusion
R5606 T8368 T8369 det the,exons
R5607 T8369 T8367 pobj exons,between
R5608 T8370 T8369 nummod 5,exons
R5609 T8371 T8370 punct ′,5
R5610 T8372 T8369 prep of,exons
R5611 T8373 T8374 det the,gene
R5612 T8374 T8372 pobj gene,of
R5613 T8375 T8374 amod trapped,gene
R5614 T8376 T8374 cc and,gene
R5615 T8377 T8378 det a,reporter
R5616 T8378 T8374 conj reporter,gene
R5617 T8379 T8378 punct ", ",reporter
R5618 T8380 T8378 appos βgeo,reporter
R5619 T8381 T8380 punct (,βgeo
R5620 T8382 T8383 det a,fusion
R5621 T8383 T8380 appos fusion,βgeo
R5622 T8384 T8383 prep of,fusion
R5623 T8385 T8386 compound β,galactosidase
R5624 T8386 T8384 pobj galactosidase,of
R5625 T8387 T8386 punct -,galactosidase
R5626 T8388 T8386 cc and,galactosidase
R5627 T8389 T8390 compound neomycin,phosphotransferase
R5628 T8390 T8386 conj phosphotransferase,galactosidase
R5629 T8391 T8390 nummod II,phosphotransferase
R5630 T8392 T8350 punct ),designed
R5631 T8393 T8350 punct .,designed
R5632 T8395 T8396 det The,locus
R5633 T8396 T8400 nsubj locus,creates
R5634 T8397 T8398 npadvmod gene,trapped
R5635 T8398 T8396 amod trapped,locus
R5636 T8399 T8398 punct -,trapped
R5637 T8401 T8402 det a,transcript
R5638 T8402 T8400 dobj transcript,creates
R5639 T8403 T8402 compound fusion,transcript
R5640 T8404 T8402 acl containing,transcript
R5641 T8405 T8406 nmod exons,3
R5642 T8406 T8404 dobj 3,containing
R5643 T8407 T8406 nummod 1,3
R5644 T8408 T8406 punct –,3
R5645 T8409 T8406 prep of,3
R5646 T8410 T8409 pobj Trip13,of
R5647 T8411 T8410 cc and,Trip13
R5648 T8412 T8410 conj βgeo,Trip13
R5649 T8413 T8400 punct .,creates
R5650 T8415 T8416 aux To,identify
R5651 T8416 T8417 advcl identify,performed
R5652 T8418 T8419 det the,site
R5653 T8419 T8416 dobj site,identify
R5654 T8420 T8419 amod exact,site
R5655 T8421 T8419 compound insertion,site
R5656 T8422 T8419 prep within,site
R5657 T8423 T8422 pobj intron,within
R5658 T8424 T8423 nummod 3,intron
R5659 T8425 T8417 punct ", ",performed
R5660 T8426 T8417 nsubjpass PCR,performed
R5661 T8427 T8417 auxpass was,performed
R5662 T8428 T8417 advcl using,performed
R5663 T8429 T8430 nummod one,primer
R5664 T8430 T8428 dobj primer,using
R5665 T8431 T8430 prep within,primer
R5666 T8432 T8433 det the,vector
R5667 T8433 T8431 pobj vector,within
R5668 T8434 T8435 compound gene,trap
R5669 T8435 T8433 compound trap,vector
R5670 T8436 T8430 punct ", ",primer
R5671 T8437 T8430 cc and,primer
R5672 T8438 T8439 det the,primer
R5673 T8439 T8430 conj primer,primer
R5674 T8440 T8439 amod other,primer
R5675 T8441 T8439 prep at,primer
R5676 T8442 T8443 amod various,positions
R5677 T8443 T8441 pobj positions,at
R5678 T8444 T8443 prep in,positions
R5679 T8445 T8444 pobj intron,in
R5680 T8446 T8445 nummod 3,intron
R5681 T8447 T8443 acl pointing,positions
R5682 T8448 T8447 prep towards,pointing
R5683 T8449 T8450 det the,end
R5684 T8450 T8448 pobj end,towards
R5685 T8451 T8450 nummod 3,end
R5686 T8452 T8451 punct ′,3
R5687 T8453 T8450 prep of,end
R5688 T8454 T8455 det the,gene
R5689 T8455 T8453 pobj gene,of
R5690 T8456 T8417 punct .,performed
R5691 T8458 T8459 nsubjpass Product,sequenced
R5692 T8460 T8458 prep from,Product
R5693 T8461 T8462 det a,reaction
R5694 T8462 T8460 pobj reaction,from
R5695 T8463 T8462 amod productive,reaction
R5696 T8464 T8459 auxpass was,sequenced
R5697 T8465 T8459 punct ", ",sequenced
R5698 T8466 T8459 advcl revealing,sequenced
R5699 T8467 T8468 mark that,was
R5700 T8468 T8466 ccomp was,revealing
R5701 T8469 T8470 det the,site
R5702 T8470 T8468 nsubj site,was
R5703 T8471 T8470 compound insertion,site
R5704 T8472 T8473 nummod 445,bp
R5705 T8473 T8474 npadvmod bp,into
R5706 T8474 T8468 prep into,was
R5707 T8475 T8474 pobj intron,into
R5708 T8476 T8475 nummod 3,intron
R5709 T8477 T8459 punct .,sequenced
R5710 T8522 T8521 prep of,Genotyping
R5711 T8523 T8522 pobj mice,of
R5712 T8524 T8521 punct .,Genotyping
R5713 T8526 T8527 nummod Three,primers
R5714 T8527 T8528 nsubjpass primers,used
R5715 T8529 T8528 auxpass were,used
R5716 T8530 T8531 aux to,distinguish
R5717 T8531 T8528 advcl distinguish,used
R5718 T8532 T8533 amod wild,type
R5719 T8533 T8535 nmod type,alleles
R5720 T8534 T8533 punct -,type
R5721 T8535 T8531 dobj alleles,distinguish
R5722 T8536 T8533 cc and,type
R5723 T8537 T8533 conj mutant,type
R5724 T8538 T8535 prep of,alleles
R5725 T8539 T8538 pobj Trip13,of
R5726 T8540 T8535 punct : ,alleles
R5727 T8541 T8535 appos primer,alleles
R5728 T8542 T8541 nummod 1,primer
R5729 T8543 T8541 punct ", ",primer
R5730 T8544 T8545 nummod 5,CGTCGCTCCATTGCTTTGTGC
R5731 T8545 T8541 appos CGTCGCTCCATTGCTTTGTGC,primer
R5732 T8546 T8544 punct ′,5
R5733 T8547 T8545 punct -,CGTCGCTCCATTGCTTTGTGC
R5734 T8548 T8545 punct -,CGTCGCTCCATTGCTTTGTGC
R5735 T8549 T8545 nummod 3,CGTCGCTCCATTGCTTTGTGC
R5736 T8550 T8545 punct ′,CGTCGCTCCATTGCTTTGTGC
R5737 T8551 T8541 punct ;,primer
R5738 T8552 T8541 conj primer,primer
R5739 T8553 T8552 nummod 2,primer
R5740 T8554 T8552 punct ", ",primer
R5741 T8555 T8556 nummod 5,AGTAGTGGTACACTGTATTTTTGCTTTCATTGA
R5742 T8556 T8552 appos AGTAGTGGTACACTGTATTTTTGCTTTCATTGA,primer
R5743 T8557 T8555 punct ′,5
R5744 T8558 T8556 punct -,AGTAGTGGTACACTGTATTTTTGCTTTCATTGA
R5745 T8559 T8556 punct -,AGTAGTGGTACACTGTATTTTTGCTTTCATTGA
R5746 T8560 T8556 nummod 3,AGTAGTGGTACACTGTATTTTTGCTTTCATTGA
R5747 T8561 T8556 punct ′,AGTAGTGGTACACTGTATTTTTGCTTTCATTGA
R5748 T8562 T8552 punct ;,primer
R5749 T8563 T8552 cc and,primer
R5750 T8564 T8552 conj primer,primer
R5751 T8565 T8564 nummod 3,primer
R5752 T8566 T8564 punct ", ",primer
R5753 T8567 T8568 nummod 5,GTAGATCCCGGCGCTCTTACCAA
R5754 T8568 T8564 appos GTAGATCCCGGCGCTCTTACCAA,primer
R5755 T8569 T8567 punct ′,5
R5756 T8570 T8568 punct -,GTAGATCCCGGCGCTCTTACCAA
R5757 T8571 T8568 punct -,GTAGATCCCGGCGCTCTTACCAA
R5758 T8572 T8568 nummod 3,GTAGATCCCGGCGCTCTTACCAA
R5759 T8573 T8568 punct ′,GTAGATCCCGGCGCTCTTACCAA
R5760 T8574 T8528 punct .,used
R5761 T8576 T8577 nmod Primers,1
R5762 T8577 T8578 nsubjpass 1,located
R5763 T8579 T8577 cc and,1
R5764 T8580 T8577 conj 2,1
R5765 T8581 T8578 auxpass are,located
R5766 T8582 T8578 advmod upstream,located
R5767 T8583 T8582 cc and,upstream
R5768 T8584 T8582 conj downstream,upstream
R5769 T8585 T8584 punct ", ",downstream
R5770 T8586 T8584 conj respectively,downstream
R5771 T8587 T8586 punct ", ",respectively
R5772 T8588 T8586 conj of,respectively
R5773 T8589 T8590 det the,insertion
R5774 T8590 T8588 pobj insertion,of
R5775 T8591 T8592 compound gene,trap
R5776 T8592 T8590 compound trap,insertion
R5777 T8593 T8590 prep within,insertion
R5778 T8594 T8595 det the,intron
R5779 T8595 T8593 pobj intron,within
R5780 T8596 T8595 nummod 3,intron
R5781 T8597 T8578 punct .,located
R5782 T8599 T8600 nsubj Primer,corresponds
R5783 T8601 T8599 nummod 3,Primer
R5784 T8602 T8600 prep to,corresponds
R5785 T8603 T8604 compound pGTlxf,sequence
R5786 T8604 T8602 pobj sequence,to
R5787 T8605 T8600 punct .,corresponds
R5788 T8607 T8608 nmod Primers,1
R5789 T8608 T8609 nsubj 1,amplify
R5790 T8609 T8612 ccomp amplify,amplify
R5791 T8610 T8608 cc and,1
R5792 T8611 T8608 conj 2,1
R5793 T8613 T8614 det a,band
R5794 T8614 T8609 dobj band,amplify
R5795 T8615 T8616 nummod 700,bp
R5796 T8616 T8614 compound bp,band
R5797 T8617 T8616 punct -,bp
R5798 T8618 T8614 prep from,band
R5799 T8619 T8620 det a,allele
R5800 T8620 T8618 pobj allele,from
R5801 T8621 T8622 amod wild,type
R5802 T8622 T8620 compound type,allele
R5803 T8623 T8622 punct -,type
R5804 T8624 T8612 punct ;,amplify
R5805 T8625 T8626 nmod primers,1
R5806 T8626 T8612 nsubj 1,amplify
R5807 T8627 T8626 cc and,1
R5808 T8628 T8626 conj 3,1
R5809 T8629 T8630 det a,fragment
R5810 T8630 T8612 dobj fragment,amplify
R5811 T8631 T8632 nummod 540,bp
R5812 T8632 T8630 compound bp,fragment
R5813 T8633 T8632 punct -,bp
R5814 T8634 T8630 prep from,fragment
R5815 T8635 T8636 det a,allele
R5816 T8636 T8634 pobj allele,from
R5817 T8637 T8636 compound mutant,allele
R5818 T8638 T8612 punct .,amplify
R5819 T8640 T8641 amod Separate,reactions
R5820 T8641 T8642 nsubjpass reactions,used
R5821 T8643 T8642 auxpass were,used
R5822 T8644 T8645 aux to,assay
R5823 T8645 T8642 advcl assay,used
R5824 T8646 T8647 det the,presence
R5825 T8647 T8645 dobj presence,assay
R5826 T8648 T8647 cc or,presence
R5827 T8649 T8647 conj absence,presence
R5828 T8650 T8647 prep of,presence
R5829 T8651 T8652 det each,amplicon
R5830 T8652 T8650 pobj amplicon,of
R5831 T8653 T8645 prep from,assay
R5832 T8654 T8655 det a,sample
R5833 T8655 T8653 pobj sample,from
R5834 T8656 T8655 compound DNA,sample
R5835 T8657 T8642 punct .,used
R5836 T8659 T8660 det The,conditions
R5837 T8660 T8662 nsubj conditions,were
R5838 T8661 T8660 compound cycling,conditions
R5839 T8663 T8662 punct : ,were
R5840 T8664 T8665 nummod 94,°C
R5841 T8665 T8662 attr °C,were
R5842 T8666 T8667 nummod 2,min
R5843 T8667 T8665 npadvmod min,°C
R5844 T8668 T8665 punct ;,°C
R5845 T8669 T8670 nummod 35,cycles
R5846 T8670 T8665 conj cycles,°C
R5847 T8671 T8670 prep of,cycles
R5848 T8672 T8673 nummod 94,°C
R5849 T8673 T8671 pobj °C,of
R5850 T8674 T8675 nummod 30,s
R5851 T8675 T8670 npadvmod s,cycles
R5852 T8676 T8670 punct ", ",cycles
R5853 T8677 T8678 nummod 57,°C
R5854 T8678 T8670 conj °C,cycles
R5855 T8679 T8680 nummod 45,s
R5856 T8680 T8678 npadvmod s,°C
R5857 T8681 T8678 punct ", ",°C
R5858 T8682 T8678 cc and,°C
R5859 T8683 T8684 nummod 72,°C
R5860 T8684 T8678 conj °C,°C
R5861 T8685 T8686 nummod 50,s
R5862 T8686 T8684 npadvmod s,°C
R5863 T8687 T8670 punct ;,cycles
R5864 T8688 T8670 cc and,cycles
R5865 T8689 T8690 nummod 72,°C
R5866 T8690 T8670 conj °C,cycles
R5867 T8691 T8692 nummod 2,min
R5868 T8692 T8690 npadvmod min,°C
R5869 T8693 T8662 punct .,were
R5870 T8717 T8718 compound RT,PCR
R5871 T8719 T8718 punct -,PCR
R5872 T8720 T8718 punct .,PCR
R5873 T8722 T8723 amod Total,RNA
R5874 T8723 T8724 nsubjpass RNA,isolated
R5875 T8725 T8724 auxpass was,isolated
R5876 T8726 T8724 prep from,isolated
R5877 T8727 T8728 amod adult,testes
R5878 T8728 T8726 pobj testes,from
R5879 T8729 T8724 prep with,isolated
R5880 T8730 T8731 det the,Kit
R5881 T8731 T8729 pobj Kit,with
R5882 T8732 T8731 compound RNeasy,Kit
R5883 T8733 T8731 compound Mini,Kit
R5884 T8734 T8735 punct (,Qiagen
R5885 T8735 T8731 parataxis Qiagen,Kit
R5886 T8736 T8735 punct ", ",Qiagen
R5887 T8737 T8735 npadvmod http://www.qiagen.com,Qiagen
R5888 T8738 T8735 punct ),Qiagen
R5889 T8739 T8724 punct ", ",isolated
R5890 T8740 T8724 cc and,isolated
R5891 T8741 T8742 nummod 4.0,μg
R5892 T8742 T8743 nsubj μg,primed
R5893 T8743 T8724 conj primed,isolated
R5894 T8744 T8743 aux was,primed
R5895 T8745 T8746 compound oligo,dT
R5896 T8746 T8743 npadvmod dT,primed
R5897 T8747 T8743 punct –,primed
R5898 T8748 T8743 cc and,primed
R5899 T8749 T8750 advmod reverse,transcribed
R5900 T8750 T8743 conj transcribed,primed
R5901 T8751 T8750 punct -,transcribed
R5902 T8752 T8743 prep with,primed
R5903 T8753 T8752 pobj Superscript,with
R5904 T8754 T8753 nummod II,Superscript
R5905 T8755 T8756 punct (,Stratagene
R5906 T8756 T8753 parataxis Stratagene,Superscript
R5907 T8757 T8756 punct ", ",Stratagene
R5908 T8758 T8756 npadvmod http://www.stratagene.com,Stratagene
R5909 T8759 T8756 punct ),Stratagene
R5910 T8760 T8743 punct .,primed
R5911 T8762 T8763 det The,sequence
R5912 T8763 T8769 nsubjpass sequence,amplified
R5913 T8764 T8763 amod entire,sequence
R5914 T8765 T8763 nmod Trip13,sequence
R5915 T8766 T8767 npadvmod protein,coding
R5916 T8767 T8763 amod coding,sequence
R5917 T8768 T8767 punct -,coding
R5918 T8770 T8769 auxpass was,amplified
R5919 T8771 T8769 prep with,amplified
R5920 T8772 T8773 nmod primers,ATGGACGAGGCGGTG
R5921 T8773 T8771 pobj ATGGACGAGGCGGTG,with
R5922 T8774 T8773 nummod 5,ATGGACGAGGCGGTG
R5923 T8775 T8774 punct ′,5
R5924 T8776 T8773 punct -,ATGGACGAGGCGGTG
R5925 T8777 T8773 punct -,ATGGACGAGGCGGTG
R5926 T8778 T8773 nummod 3,ATGGACGAGGCGGTG
R5927 T8779 T8773 punct ′,ATGGACGAGGCGGTG
R5928 T8780 T8773 cc and,ATGGACGAGGCGGTG
R5929 T8781 T8782 nummod 5,TCAAACATAAGCTGAAAGTT
R5930 T8782 T8773 conj TCAAACATAAGCTGAAAGTT,ATGGACGAGGCGGTG
R5931 T8783 T8781 punct ′,5
R5932 T8784 T8782 punct -,TCAAACATAAGCTGAAAGTT
R5933 T8785 T8782 punct -,TCAAACATAAGCTGAAAGTT
R5934 T8786 T8782 nummod 3,TCAAACATAAGCTGAAAGTT
R5935 T8787 T8782 punct ′,TCAAACATAAGCTGAAAGTT
R5936 T8788 T8769 punct .,amplified
R5937 T8790 T8791 det The,conditions
R5938 T8791 T8793 nsubj conditions,were
R5939 T8792 T8791 compound cycling,conditions
R5940 T8794 T8793 punct : ,were
R5941 T8795 T8796 nummod 94,°C
R5942 T8796 T8793 attr °C,were
R5943 T8797 T8798 nummod 2,min
R5944 T8798 T8796 npadvmod min,°C
R5945 T8799 T8796 punct ;,°C
R5946 T8800 T8801 nummod 94,°C
R5947 T8801 T8796 conj °C,°C
R5948 T8802 T8803 nummod 30,s
R5949 T8803 T8801 npadvmod s,°C
R5950 T8804 T8801 punct ", ",°C
R5951 T8805 T8806 nummod 55,°C
R5952 T8806 T8801 conj °C,°C
R5953 T8807 T8808 nummod 45,s
R5954 T8808 T8806 npadvmod s,°C
R5955 T8809 T8806 punct ", ",°C
R5956 T8810 T8806 cc and,°C
R5957 T8811 T8812 nummod 72,°C
R5958 T8812 T8806 conj °C,°C
R5959 T8813 T8814 nummod 80,s
R5960 T8814 T8812 npadvmod s,°C
R5961 T8815 T8812 prep for,°C
R5962 T8816 T8817 nummod 35,cycles
R5963 T8817 T8815 pobj cycles,for
R5964 T8818 T8801 punct ;,°C
R5965 T8819 T8801 cc and,°C
R5966 T8820 T8821 nummod 72,°C
R5967 T8821 T8801 conj °C,°C
R5968 T8822 T8823 nummod 2,min
R5969 T8823 T8821 npadvmod min,°C
R5970 T8824 T8793 punct .,were
R5971 T8826 T8827 det The,primers
R5972 T8827 T8828 nsubj primers,were
R5973 T8829 T8827 prep for,primers
R5974 T8830 T8829 pcomp amplifying,for
R5975 T8831 T8832 det the,sequence
R5976 T8832 T8830 dobj sequence,amplifying
R5977 T8833 T8832 compound Med31,sequence
R5978 T8834 T8832 compound coding,sequence
R5979 T8835 T8830 prep as,amplifying
R5980 T8836 T8835 pobj control,as
R5981 T8837 T8828 punct : ,were
R5982 T8838 T8839 nummod 5,ATGGCCGCGGCCGTCGCTATGG
R5983 T8839 T8828 attr ATGGCCGCGGCCGTCGCTATGG,were
R5984 T8840 T8838 punct ′,5
R5985 T8841 T8839 punct -,ATGGCCGCGGCCGTCGCTATGG
R5986 T8842 T8839 punct -,ATGGCCGCGGCCGTCGCTATGG
R5987 T8843 T8839 nummod 3,ATGGCCGCGGCCGTCGCTATGG
R5988 T8844 T8839 punct ′,ATGGCCGCGGCCGTCGCTATGG
R5989 T8845 T8839 cc and,ATGGCCGCGGCCGTCGCTATGG
R5990 T8846 T8847 nummod 5,TCATTTCCCTGCTGTGTTATTCTGCTGCTGCTGC
R5991 T8847 T8839 conj TCATTTCCCTGCTGTGTTATTCTGCTGCTGCTGC,ATGGCCGCGGCCGTCGCTATGG
R5992 T8848 T8846 punct ′,5
R5993 T8849 T8847 punct -,TCATTTCCCTGCTGTGTTATTCTGCTGCTGCTGC
R5994 T8850 T8847 punct -,TCATTTCCCTGCTGTGTTATTCTGCTGCTGCTGC
R5995 T8851 T8847 nummod 3,TCATTTCCCTGCTGTGTTATTCTGCTGCTGCTGC
R5996 T8852 T8847 punct ′,TCATTTCCCTGCTGTGTTATTCTGCTGCTGCTGC
R5997 T8853 T8828 punct .,were
R5998 T8855 T8856 det The,conditions
R5999 T8856 T8858 nsubj conditions,were
R6000 T8857 T8856 compound cycling,conditions
R6001 T8859 T8858 punct : ,were
R6002 T8860 T8861 nummod 94,°C
R6003 T8861 T8858 attr °C,were
R6004 T8862 T8863 nummod 2,min
R6005 T8863 T8861 npadvmod min,°C
R6006 T8864 T8861 punct ;,°C
R6007 T8865 T8866 nummod 94,°C
R6008 T8866 T8861 conj °C,°C
R6009 T8867 T8868 nummod 30,s
R6010 T8868 T8866 npadvmod s,°C
R6011 T8869 T8866 punct ", ",°C
R6012 T8870 T8871 nummod 55,°C
R6013 T8871 T8866 conj °C,°C
R6014 T8872 T8873 nummod 30,s
R6015 T8873 T8871 npadvmod s,°C
R6016 T8874 T8871 punct ", ",°C
R6017 T8875 T8871 cc and,°C
R6018 T8876 T8877 nummod 72,°C
R6019 T8877 T8871 conj °C,°C
R6020 T8878 T8879 nummod 35,s
R6021 T8879 T8877 npadvmod s,°C
R6022 T8880 T8877 prep for,°C
R6023 T8881 T8882 nummod 35,cycles
R6024 T8882 T8880 pobj cycles,for
R6025 T8883 T8866 punct ;,°C
R6026 T8884 T8866 cc and,°C
R6027 T8885 T8886 nummod 72,°C
R6028 T8886 T8866 conj °C,°C
R6029 T8887 T8888 nummod 2,min
R6030 T8888 T8886 npadvmod min,°C
R6031 T8889 T8858 punct .,were
R6034 T8919 T8918 cc and,Development
R6035 T8920 T8918 conj purification,Development
R6036 T8921 T8918 prep of,Development
R6037 T8922 T8923 compound chicken,antibodies
R6038 T8923 T8921 pobj antibodies,of
R6039 T8924 T8918 punct .,Development
R6040 T8926 T8927 det A,peptide
R6041 T8927 T8928 nsubjpass peptide,conjugated
R6042 T8929 T8927 acl corresponding,peptide
R6043 T8930 T8929 prep to,corresponding
R6044 T8931 T8932 nmod amino,25
R6045 T8932 T8930 pobj 25,to
R6046 T8933 T8932 nmod acids,25
R6047 T8934 T8935 punct –,40
R6048 T8935 T8932 prep 40,25
R6049 T8936 T8932 prep of,25
R6050 T8937 T8936 pobj TRIP13,of
R6051 T8938 T8927 punct ", ",peptide
R6052 T8939 T8927 appos VLQRSGSTAKKEDIK,peptide
R6053 T8940 T8928 punct ", ",conjugated
R6054 T8941 T8928 auxpass was,conjugated
R6055 T8942 T8928 prep to,conjugated
R6056 T8943 T8942 pobj KLH,to
R6057 T8944 T8928 cc and,conjugated
R6058 T8945 T8928 conj used,conjugated
R6059 T8946 T8947 aux to,immunize
R6060 T8947 T8945 advcl immunize,used
R6061 T8948 T8947 dobj chickens,immunize
R6062 T8949 T8950 punct (,done
R6063 T8950 T8945 parataxis done,used
R6064 T8951 T8950 prep by,done
R6065 T8952 T8953 compound Sigma,Genosys
R6066 T8953 T8951 pobj Genosys,by
R6067 T8954 T8953 punct ", ",Genosys
R6068 T8955 T8953 npadvmod http://www.sigmaaldrich.com,Genosys
R6069 T8956 T8950 punct ),done
R6070 T8957 T8928 punct .,conjugated
R6071 T8959 T8960 amod Polyclonal,IgY
R6072 T8960 T8961 nsubjpass IgY,isolated
R6073 T8962 T8961 auxpass was,isolated
R6074 T8963 T8961 prep from,isolated
R6075 T8964 T8963 pobj eggs,from
R6076 T8965 T8961 prep with,isolated
R6077 T8966 T8967 det the,kit
R6078 T8967 T8965 pobj kit,with
R6079 T8968 T8969 compound Eggcellent,Chicken
R6080 T8969 T8967 compound Chicken,kit
R6081 T8970 T8967 compound IgY,kit
R6082 T8971 T8967 compound Purification,kit
R6083 T8972 T8973 punct (,Pierce
R6084 T8973 T8967 parataxis Pierce,kit
R6085 T8974 T8973 punct ", ",Pierce
R6086 T8975 T8973 npadvmod http://www.piercenet.com,Pierce
R6087 T8976 T8973 punct ),Pierce
R6088 T8977 T8961 punct .,isolated
R6089 T8979 T8980 compound IgY,antibodies
R6090 T8980 T8981 nsubjpass antibodies,purified
R6091 T8982 T8981 auxpass were,purified
R6092 T8983 T8981 advmod then,purified
R6093 T8984 T8981 dep affinity,purified
R6094 T8985 T8981 advcl using,purified
R6095 T8986 T8987 det the,peptide
R6096 T8987 T8985 dobj peptide,using
R6097 T8988 T8987 amod immunizing,peptide
R6098 T8989 T8987 amod synthetic,peptide
R6099 T8990 T8981 punct .,purified
R6100 T9024 T9025 compound Western,blotting
R6101 T9026 T9025 punct .,blotting
R6102 T9028 T9029 nummod 50,μg
R6103 T9029 T9030 nsubjpass μg,separated
R6104 T9031 T9029 prep of,μg
R6105 T9032 T9033 compound testis,extract
R6106 T9033 T9031 pobj extract,of
R6107 T9034 T9029 prep in,μg
R6108 T9035 T9036 compound RIPA,buffer
R6109 T9036 T9034 pobj buffer,in
R6110 T9037 T9030 auxpass was,separated
R6111 T9038 T9030 agent by,separated
R6112 T9039 T9040 nummod 8,%
R6113 T9040 T9041 compound %,PAGE
R6114 T9041 T9038 pobj PAGE,by
R6115 T9042 T9041 compound SDS,PAGE
R6116 T9043 T9041 punct -,PAGE
R6117 T9044 T9030 cc and,separated
R6118 T9045 T9030 conj electrotransferred,separated
R6119 T9046 T9045 prep onto,electrotransferred
R6120 T9047 T9048 det a,membrane
R6121 T9048 T9046 pobj membrane,onto
R6122 T9049 T9048 compound Pure,membrane
R6123 T9050 T9048 compound Nitrocellulose,membrane
R6124 T9051 T9052 punct (,Rad
R6125 T9052 T9048 parataxis Rad,membrane
R6126 T9053 T9052 compound Bio,Rad
R6127 T9054 T9052 punct -,Rad
R6128 T9055 T9052 punct ", ",Rad
R6129 T9056 T9052 npadvmod http://www.biorad.com,Rad
R6130 T9057 T9052 punct ),Rad
R6131 T9058 T9030 punct .,separated
R6132 T9060 T9061 det The,membrane
R6133 T9061 T9062 nsubjpass membrane,incubated
R6134 T9063 T9062 auxpass was,incubated
R6135 T9064 T9062 prep with,incubated
R6136 T9065 T9066 det a,antibody
R6137 T9066 T9064 pobj antibody,with
R6138 T9067 T9068 amod polyclonal,rabbit
R6139 T9068 T9066 nmod rabbit,antibody
R6140 T9069 T9066 amod anti-human,antibody
R6141 T9070 T9066 compound TRIP13,antibody
R6142 T9071 T9072 punct (,Genway
R6143 T9072 T9066 parataxis Genway,antibody
R6144 T9073 T9074 nummod 18,42687
R6145 T9074 T9072 dep 42687,Genway
R6146 T9075 T9074 punct -,42687
R6147 T9076 T9074 nummod 003,42687
R6148 T9077 T9074 punct -,42687
R6149 T9078 T9072 punct ;,Genway
R6150 T9079 T9072 punct ", ",Genway
R6151 T9080 T9072 npadvmod http://www.genwaybio.com,Genway
R6152 T9081 T9072 punct ),Genway
R6153 T9082 T9062 punct .,incubated
R6154 T9084 T9085 prep According,was
R6155 T9086 T9084 prep to,According
R6156 T9087 T9088 det the,manufacturer
R6157 T9088 T9086 pobj manufacturer,to
R6158 T9089 T9085 punct ", ",was
R6159 T9090 T9091 det the,immunogen
R6160 T9091 T9085 nsubj immunogen,was
R6161 T9092 T9093 det a,peptide
R6162 T9093 T9085 attr peptide,was
R6163 T9094 T9093 amod synthetic,peptide
R6164 T9095 T9093 acl embedded,peptide
R6165 T9096 T9095 prep in,embedded
R6166 T9097 T9096 pobj sequence,in
R6167 T9098 T9099 nsubj we,deduced
R6168 T9099 T9097 advcl deduced,sequence
R6169 T9100 T9101 aux to,correspond
R6170 T9101 T9099 xcomp correspond,deduced
R6171 T9102 T9101 prep to,correspond
R6172 T9103 T9102 pobj exon,to
R6173 T9104 T9103 nummod 3,exon
R6174 T9105 T9085 punct .,was
R6175 T9107 T9108 nsubjpass Binding,detected
R6176 T9109 T9108 auxpass was,detected
R6177 T9110 T9108 prep by,detected
R6178 T9111 T9112 compound chemiluminescence,kit
R6179 T9112 T9110 pobj kit,by
R6180 T9113 T9112 compound ECL,kit
R6181 T9114 T9115 punct (,Pierce
R6182 T9115 T9112 parataxis Pierce,kit
R6183 T9116 T9115 punct ),Pierce
R6184 T9117 T9108 advcl using,detected
R6185 T9118 T9119 det a,conjugate
R6186 T9119 T9117 dobj conjugate,using
R6187 T9120 T9119 nmod rabbit,conjugate
R6188 T9121 T9119 amod anti-chicken,conjugate
R6189 T9122 T9119 compound IgG,conjugate
R6190 T9123 T9124 compound horseradish,peroxidase
R6191 T9124 T9119 compound peroxidase,conjugate
R6192 T9125 T9126 punct (,Pierce
R6193 T9126 T9119 parataxis Pierce,conjugate
R6194 T9127 T9126 punct ),Pierce
R6195 T9128 T9108 punct .,detected
R6196 T9148 T9149 amod Histological,analyses
R6197 T9150 T9149 punct .,analyses
R6198 T9152 T9153 nsubjpass Testes,fixed
R6199 T9154 T9152 cc or,Testes
R6200 T9155 T9152 conj ovaries,Testes
R6201 T9156 T9153 auxpass were,fixed
R6202 T9157 T9153 prep in,fixed
R6203 T9158 T9157 pobj Bouin,in
R6204 T9159 T9158 case 's,Bouin
R6205 T9160 T9153 punct ", ",fixed
R6206 T9161 T9153 conj embedded,fixed
R6207 T9162 T9161 prep in,embedded
R6208 T9163 T9162 pobj paraffin,in
R6209 T9164 T9161 punct ", ",embedded
R6210 T9165 T9161 conj sectioned,embedded
R6211 T9166 T9165 prep at,sectioned
R6212 T9167 T9168 nummod 6,μm
R6213 T9168 T9166 pobj μm,at
R6214 T9169 T9165 punct ", ",sectioned
R6215 T9170 T9165 cc and,sectioned
R6216 T9171 T9165 conj stained,sectioned
R6217 T9172 T9171 prep by,stained
R6218 T9173 T9172 pobj hematoxylin,by
R6219 T9174 T9173 cc and,hematoxylin
R6220 T9175 T9173 conj eosin,hematoxylin
R6221 T9176 T9153 punct .,fixed
R6222 T9178 T9179 compound Antigen,retrieval
R6223 T9179 T9180 nsubj retrieval,was
R6224 T9181 T9179 prep for,retrieval
R6225 T9182 T9181 pobj immunohistochemistry,for
R6226 T9183 T9182 prep of,immunohistochemistry
R6227 T9184 T9185 compound testis,sections
R6228 T9185 T9183 pobj sections,of
R6229 T9186 T9187 mark as,described
R6230 T9187 T9180 advcl described,was
R6231 T9188 T9189 punct [,60
R6232 T9189 T9180 parataxis 60,was
R6233 T9190 T9189 punct ],60
R6234 T9191 T9180 punct .,was
R6235 T9193 T9194 nmod Oocyte,numbers
R6236 T9194 T9197 nsubjpass numbers,counted
R6237 T9195 T9193 cc and,Oocyte
R6238 T9196 T9193 conj follicle,Oocyte
R6239 T9198 T9197 auxpass were,counted
R6240 T9199 T9200 mark as,described
R6241 T9200 T9197 advcl described,counted
R6242 T9201 T9202 punct [,61
R6243 T9202 T9197 parataxis 61,counted
R6244 T9203 T9202 punct ],61
R6245 T9204 T9197 punct .,counted
R6246 T9206 T9207 advmod Only,follicles
R6247 T9207 T9208 nsubjpass follicles,scored
R6248 T9209 T9207 acl containing,follicles
R6249 T9210 T9211 det an,oocyte
R6250 T9211 T9209 dobj oocyte,containing
R6251 T9212 T9211 prep with,oocyte
R6252 T9213 T9214 det a,nucleus
R6253 T9214 T9212 pobj nucleus,with
R6254 T9215 T9216 advmod clearly,visible
R6255 T9216 T9214 amod visible,nucleus
R6256 T9217 T9208 auxpass were,scored
R6257 T9218 T9208 punct .,scored
R6260 T9323 T9322 punct .,Immunocytochemistry
R6261 T9325 T9326 nsubjpass Immunolabeling,performed
R6262 T9327 T9325 prep of,Immunolabeling
R6263 T9328 T9329 compound surface,spermatocytes
R6264 T9329 T9327 pobj spermatocytes,of
R6265 T9330 T9329 punct -,spermatocytes
R6266 T9331 T9329 compound spread,spermatocytes
R6267 T9332 T9329 cc and,spermatocytes
R6268 T9333 T9329 conj oocytes,spermatocytes
R6269 T9334 T9326 auxpass was,performed
R6270 T9335 T9336 mark as,described
R6271 T9336 T9326 advcl described,performed
R6272 T9337 T9338 punct [,62
R6273 T9338 T9326 parataxis 62,performed
R6274 T9339 T9338 nummod 39,62
R6275 T9340 T9338 punct ",",62
R6276 T9341 T9338 punct ],62
R6277 T9342 T9326 punct .,performed
R6278 T9344 T9345 aux To,reach
R6279 T9345 T9346 advcl reach,identified
R6280 T9347 T9345 dobj conclusions,reach
R6281 T9348 T9347 prep on,conclusions
R6282 T9349 T9350 det the,pattern
R6283 T9350 T9348 pobj pattern,on
R6284 T9351 T9350 prep of,pattern
R6285 T9352 T9351 pobj staining,of
R6286 T9353 T9350 prep for,pattern
R6287 T9354 T9355 amod various,proteins
R6288 T9355 T9353 pobj proteins,for
R6289 T9356 T9346 punct ", ",identified
R6290 T9357 T9358 nummod 30,nuclei
R6291 T9358 T9346 nsubjpass nuclei,identified
R6292 T9359 T9360 punct (,indicated
R6293 T9360 T9358 parataxis indicated,nuclei
R6294 T9361 T9360 mark unless,indicated
R6295 T9362 T9360 advmod otherwise,indicated
R6296 T9363 T9360 punct ),indicated
R6297 T9364 T9365 advmod well,spread
R6298 T9365 T9358 amod spread,nuclei
R6299 T9366 T9365 punct -,spread
R6300 T9367 T9358 prep of,nuclei
R6301 T9368 T9369 amod particular,stages
R6302 T9369 T9367 pobj stages,of
R6303 T9370 T9369 amod meiotic,stages
R6304 T9371 T9346 auxpass were,identified
R6305 T9372 T9346 advmod first,identified
R6306 T9373 T9346 prep under,identified
R6307 T9374 T9375 det the,microscope
R6308 T9375 T9373 pobj microscope,under
R6309 T9376 T9375 amod fluorescent,microscope
R6310 T9377 T9346 prep on,identified
R6311 T9378 T9379 det the,basis
R6312 T9379 T9377 pobj basis,on
R6313 T9380 T9379 prep of,basis
R6314 T9381 T9382 nmod SYCP3,staining
R6315 T9382 T9380 pobj staining,of
R6316 T9383 T9381 cc or,SYCP3
R6317 T9384 T9381 conj STAG3,SYCP3
R6318 T9385 T9346 punct ", ",identified
R6319 T9386 T9387 advmod then,imaged
R6320 T9387 T9346 dep imaged,identified
R6321 T9388 T9387 prep at,imaged
R6322 T9389 T9390 det both,wavelengths
R6323 T9390 T9388 pobj wavelengths,at
R6324 T9391 T9390 amod appropriate,wavelengths
R6325 T9392 T9393 aux to,determine
R6326 T9393 T9387 advcl determine,imaged
R6327 T9394 T9395 det the,pattern
R6328 T9395 T9393 dobj pattern,determine
R6329 T9396 T9395 prep of,pattern
R6330 T9397 T9398 amod second,proteins
R6331 T9398 T9396 pobj proteins,of
R6332 T9399 T9393 prep with,determine
R6333 T9400 T9401 amod focal,patterns
R6334 T9401 T9399 pobj patterns,with
R6335 T9402 T9403 amod such,as
R6336 T9403 T9401 prep as,patterns
R6337 T9404 T9403 pobj RAD51,as
R6338 T9405 T9404 cc or,RAD51
R6339 T9406 T9404 conj RPA,RAD51
R6340 T9407 T9346 punct .,identified
R6341 T9409 T9410 mark Unless,indicated
R6342 T9410 T9412 advcl indicated,were
R6343 T9411 T9410 advmod otherwise,indicated
R6344 T9413 T9412 punct ", ",were
R6345 T9414 T9415 det the,panels
R6346 T9415 T9412 nsubj panels,were
R6347 T9416 T9415 acl shown,panels
R6348 T9417 T9416 prep in,shown
R6349 T9418 T9419 det the,figures
R6350 T9419 T9417 pobj figures,in
R6351 T9420 T9421 det the,patterns
R6352 T9421 T9412 attr patterns,were
R6353 T9422 T9421 amod exclusive,patterns
R6354 T9423 T9422 cc or,exclusive
R6355 T9424 T9422 conj predominant,exclusive
R6356 T9425 T9421 acl seen,patterns
R6357 T9426 T9412 punct .,were
R6358 T9428 T9429 det The,exception
R6359 T9429 T9430 nsubj exception,was
R6360 T9431 T9429 prep for,exception
R6361 T9432 T9433 det this,approach
R6362 T9433 T9431 pobj approach,for
R6363 T9434 T9430 prep in,was
R6364 T9435 T9436 det the,case
R6365 T9436 T9434 pobj case,in
R6366 T9437 T9436 prep of,case
R6367 T9438 T9437 pcomp staining,of
R6368 T9439 T9438 prep for,staining
R6369 T9440 T9439 pobj MLH1,for
R6370 T9441 T9440 cc or,MLH1
R6371 T9442 T9440 conj MLH3,MLH1
R6372 T9443 T9440 cc plus,MLH1
R6373 T9444 T9440 conj RAD51,MLH1
R6374 T9445 T9444 punct (,RAD51
R6375 T9446 T9447 prep in,was
R6376 T9447 T9444 advcl was,RAD51
R6377 T9448 T9449 det which,case
R6378 T9449 T9446 pcomp case,in
R6379 T9450 T9447 nsubj SYCP3,was
R6380 T9451 T9450 cc or,SYCP3
R6381 T9452 T9450 conj STAG3,SYCP3
R6382 T9453 T9447 neg not,was
R6383 T9454 T9447 acomp available,was
R6384 T9455 T9456 aux to,find
R6385 T9456 T9447 advcl find,was
R6386 T9457 T9458 compound chromosome,cores
R6387 T9458 T9456 dobj cores,find
R6388 T9459 T9430 punct ),was
R6389 T9460 T9430 punct .,was
R6390 T9462 T9463 nsubjpass Nuclei,identified
R6391 T9464 T9462 prep in,Nuclei
R6392 T9465 T9466 det this,situation
R6393 T9466 T9464 pobj situation,in
R6394 T9467 T9463 auxpass were,identified
R6395 T9468 T9463 advmod first,identified
R6396 T9469 T9463 agent by,identified
R6397 T9470 T9471 nmod MLH1,foci
R6398 T9471 T9469 pobj foci,by
R6399 T9472 T9470 punct /,MLH1
R6400 T9473 T9470 nummod 3,MLH1
R6401 T9474 T9471 amod clustering,foci
R6402 T9475 T9463 punct ", ",identified
R6403 T9476 T9477 advmod then,imaged
R6404 T9477 T9463 dep imaged,identified
R6405 T9478 T9477 prep for,imaged
R6406 T9479 T9480 det both,wavelengths
R6407 T9480 T9478 pobj wavelengths,for
R6408 T9481 T9480 amod fluorescent,wavelengths
R6409 T9482 T9463 punct .,identified
R6410 T9484 T9485 amod Primary,antibodies
R6411 T9485 T9486 nsubj antibodies,were
R6412 T9487 T9485 acl used,antibodies
R6413 T9488 T9487 prep in,used
R6414 T9489 T9490 det this,study
R6415 T9490 T9488 pobj study,in
R6416 T9491 T9492 mark as,follows
R6417 T9492 T9486 advcl follows,were
R6418 T9493 T9486 punct : ,were
R6419 T9494 T9486 dep mouse,were
R6420 T9495 T9494 amod anti-SCP3,mouse
R6421 T9496 T9497 punct (,Abcam
R6422 T9497 T9494 parataxis Abcam,mouse
R6423 T9498 T9497 dep 1,Abcam
R6424 T9499 T9500 punct :,500
R6425 T9500 T9498 prep 500,1
R6426 T9501 T9497 punct ;,Abcam
R6427 T9502 T9497 punct ", ",Abcam
R6428 T9503 T9497 npadvmod http://www.abcam.com,Abcam
R6429 T9504 T9497 punct ),Abcam
R6430 T9505 T9494 punct ;,mouse
R6431 T9506 T9507 compound rabbit,anti-SYCP1
R6432 T9507 T9494 conj anti-SYCP1,mouse
R6433 T9508 T9509 punct (,gift
R6434 T9509 T9507 parataxis gift,anti-SYCP1
R6435 T9510 T9509 dep 1,gift
R6436 T9511 T9512 punct :,"1,000"
R6437 T9512 T9510 prep "1,000",1
R6438 T9513 T9509 punct ;,gift
R6439 T9514 T9509 det a,gift
R6440 T9515 T9509 prep from,gift
R6441 T9516 T9517 compound C.,Heyting
R6442 T9517 T9515 pobj Heyting,from
R6443 T9518 T9509 punct ),gift
R6444 T9519 T9520 punct [,63
R6445 T9520 T9507 parataxis 63,anti-SYCP1
R6446 T9521 T9520 punct ],63
R6447 T9522 T9507 punct ;,anti-SYCP1
R6448 T9523 T9524 compound rabbit,anti-REC8
R6449 T9524 T9507 conj anti-REC8,anti-SYCP1
R6450 T9525 T9526 punct (,gift
R6451 T9526 T9524 parataxis gift,anti-REC8
R6452 T9527 T9526 dep 1,gift
R6453 T9528 T9529 punct :,100
R6454 T9529 T9527 prep 100,1
R6455 T9530 T9526 punct ;,gift
R6456 T9531 T9526 det a,gift
R6457 T9532 T9526 prep from,gift
R6458 T9533 T9534 compound C.,Heyting
R6459 T9534 T9532 pobj Heyting,from
R6460 T9535 T9526 punct ),gift
R6461 T9536 T9524 punct ;,anti-REC8
R6462 T9537 T9538 compound rabbit,anti-RAD51
R6463 T9538 T9524 conj anti-RAD51,anti-REC8
R6464 T9539 T9540 punct (,Products
R6465 T9540 T9538 parataxis Products,anti-RAD51
R6466 T9541 T9540 dep 1,Products
R6467 T9542 T9543 punct :,250
R6468 T9543 T9541 prep 250,1
R6469 T9544 T9540 punct ", ",Products
R6470 T9545 T9546 det this,antibody
R6471 T9546 T9548 nsubj antibody,recognizes
R6472 T9547 T9546 amod polyclonal,antibody
R6473 T9548 T9540 ccomp recognizes,Products
R6474 T9549 T9550 preconj both,RAD51
R6475 T9550 T9548 dobj RAD51,recognizes
R6476 T9551 T9550 cc and,RAD51
R6477 T9552 T9550 conj DMC1,RAD51
R6478 T9553 T9540 punct ;,Products
R6479 T9554 T9540 compound Oncogene,Products
R6480 T9555 T9540 compound Research,Products
R6481 T9556 T9540 punct ", ",Products
R6482 T9557 T9540 npadvmod http://www.merckbiosciences.co.uk,Products
R6483 T9558 T9540 punct ),Products
R6484 T9559 T9538 punct ;,anti-RAD51
R6485 T9560 T9561 compound rabbit,anti-γH2AX
R6486 T9561 T9538 conj anti-γH2AX,anti-RAD51
R6487 T9562 T9563 punct (,Biotechnology
R6488 T9563 T9561 parataxis Biotechnology,anti-γH2AX
R6489 T9564 T9563 dep 1,Biotechnology
R6490 T9565 T9566 punct :,500
R6491 T9566 T9564 prep 500,1
R6492 T9567 T9563 punct ;,Biotechnology
R6493 T9568 T9563 compound Upstate,Biotechnology
R6494 T9569 T9563 punct ", ",Biotechnology
R6495 T9570 T9563 npadvmod http://www.upstate.com/,Biotechnology
R6496 T9571 T9563 punct ),Biotechnology
R6497 T9572 T9561 punct ;,anti-γH2AX
R6498 T9573 T9574 compound rabbit,anti-STAG3
R6499 T9574 T9561 conj anti-STAG3,anti-γH2AX
R6500 T9575 T9576 punct (,gift
R6501 T9576 T9574 parataxis gift,anti-STAG3
R6502 T9577 T9576 dep 1,gift
R6503 T9578 T9579 punct :,"1,000"
R6504 T9579 T9577 prep "1,000",1
R6505 T9580 T9576 punct ;,gift
R6506 T9581 T9576 det a,gift
R6507 T9582 T9576 prep from,gift
R6508 T9583 T9584 compound R.,Jessberger
R6509 T9584 T9582 pobj Jessberger,from
R6510 T9585 T9576 punct ),gift
R6511 T9586 T9574 punct ;,anti-STAG3
R6512 T9587 T9588 compound rabbit,anti-MLH3
R6513 T9588 T9574 conj anti-MLH3,anti-STAG3
R6514 T9589 T9590 punct (,gift
R6515 T9590 T9588 parataxis gift,anti-MLH3
R6516 T9591 T9590 dep 1,gift
R6517 T9592 T9593 punct :,400
R6518 T9593 T9591 prep 400,1
R6519 T9594 T9590 punct ;,gift
R6520 T9595 T9590 det a,gift
R6521 T9596 T9590 prep from,gift
R6522 T9597 T9598 compound P.,Cohen
R6523 T9598 T9596 pobj Cohen,from
R6524 T9599 T9590 punct ),gift
R6525 T9600 T9588 punct ;,anti-MLH3
R6526 T9601 T9602 amod mouse,MLH1
R6527 T9602 T9588 conj MLH1,anti-MLH3
R6528 T9603 T9602 punct -,MLH1
R6529 T9604 T9602 amod anti-human,MLH1
R6530 T9605 T9606 punct (,Biosciences
R6531 T9606 T9602 parataxis Biosciences,MLH1
R6532 T9607 T9606 dep 1,Biosciences
R6533 T9608 T9609 punct :,50
R6534 T9609 T9607 prep 50,1
R6535 T9610 T9606 punct ;,Biosciences
R6536 T9611 T9606 compound BD,Biosciences
R6537 T9612 T9606 punct ", ",Biosciences
R6538 T9613 T9606 npadvmod http://www.bdbiosciences.com,Biosciences
R6539 T9614 T9606 punct ),Biosciences
R6540 T9615 T9602 punct ;,MLH1
R6541 T9616 T9617 compound rabbit,anti-TopBP1
R6542 T9617 T9602 conj anti-TopBP1,MLH1
R6543 T9618 T9617 punct -,anti-TopBP1
R6544 T9619 T9620 punct (,gift
R6545 T9620 T9617 parataxis gift,anti-TopBP1
R6546 T9621 T9620 dep 1,gift
R6547 T9622 T9623 punct :,100
R6548 T9623 T9621 prep 100,1
R6549 T9624 T9620 punct ;,gift
R6550 T9625 T9620 det a,gift
R6551 T9626 T9620 prep from,gift
R6552 T9627 T9628 compound J.,Chen
R6553 T9628 T9626 pobj Chen,from
R6554 T9629 T9620 punct ),gift
R6555 T9630 T9631 punct [,22
R6556 T9631 T9617 parataxis 22,anti-TopBP1
R6557 T9632 T9631 punct ],22
R6558 T9633 T9617 punct ;,anti-TopBP1
R6559 T9634 T9635 nmod mouse,H2A
R6560 T9635 T9617 conj H2A,anti-TopBP1
R6561 T9636 T9635 punct -,H2A
R6562 T9637 T9635 amod anti-ubiquityl,H2A
R6563 T9638 T9635 punct -,H2A
R6564 T9639 T9635 compound histone,H2A
R6565 T9640 T9641 punct (,Biotechnology
R6566 T9641 T9635 parataxis Biotechnology,H2A
R6567 T9642 T9641 dep 1,Biotechnology
R6568 T9643 T9644 punct :,200
R6569 T9644 T9642 prep 200,1
R6570 T9645 T9641 punct ;,Biotechnology
R6571 T9646 T9641 compound Upstate,Biotechnology
R6572 T9647 T9641 punct ),Biotechnology
R6573 T9648 T9635 punct ;,H2A
R6574 T9649 T9650 compound rabbit,anti-TRF2
R6575 T9650 T9635 conj anti-TRF2,H2A
R6576 T9651 T9650 punct -,anti-TRF2
R6577 T9652 T9653 punct (,gift
R6578 T9653 T9650 parataxis gift,anti-TRF2
R6579 T9654 T9653 dep 1,gift
R6580 T9655 T9656 punct :,500
R6581 T9656 T9654 prep 500,1
R6582 T9657 T9653 punct ;,gift
R6583 T9658 T9653 det a,gift
R6584 T9659 T9653 prep from,gift
R6585 T9660 T9661 compound T.,Lange
R6586 T9661 T9659 pobj Lange,from
R6587 T9662 T9661 compound de,Lange
R6588 T9663 T9653 punct ),gift
R6589 T9664 T9650 punct ;,anti-TRF2
R6590 T9665 T9650 cc and,anti-TRF2
R6591 T9666 T9667 compound rabbit,anti-BLM
R6592 T9667 T9650 conj anti-BLM,anti-TRF2
R6593 T9668 T9667 punct -,anti-BLM
R6594 T9669 T9670 punct (,gift
R6595 T9670 T9667 parataxis gift,anti-BLM
R6596 T9671 T9670 dep 1,gift
R6597 T9672 T9673 punct :,50
R6598 T9673 T9671 prep 50,1
R6599 T9674 T9670 punct ;,gift
R6600 T9675 T9670 det a,gift
R6601 T9676 T9670 prep from,gift
R6602 T9677 T9678 compound R.,Freire
R6603 T9678 T9676 pobj Freire,from
R6604 T9679 T9670 punct ),gift
R6605 T9680 T9486 punct .,were
R6606 T9682 T9683 det All,antibodies
R6607 T9683 T9685 nsubjpass antibodies,used
R6608 T9684 T9683 amod secondary,antibodies
R6609 T9686 T9683 acl conjugated,antibodies
R6610 T9687 T9686 prep with,conjugated
R6611 T9688 T9689 preconj either,488
R6612 T9689 T9687 pobj 488,with
R6613 T9690 T9689 nmod Alexa,488
R6614 T9691 T9689 nmod Fluor,488
R6615 T9692 T9689 cc or,488
R6616 T9693 T9689 conj 594,488
R6617 T9694 T9695 punct (,Probes
R6618 T9695 T9689 parataxis Probes,488
R6619 T9696 T9695 compound Molecular,Probes
R6620 T9697 T9695 punct ", ",Probes
R6621 T9698 T9695 npadvmod http://probes.invitrogen.com/,Probes
R6622 T9699 T9695 punct ),Probes
R6623 T9700 T9685 auxpass were,used
R6624 T9701 T9685 prep at,used
R6625 T9702 T9703 det a,dilution
R6626 T9703 T9701 pobj dilution,at
R6627 T9704 T9703 prep of,dilution
R6628 T9705 T9704 pobj 1,of
R6629 T9706 T9707 punct :,"1,000"
R6630 T9707 T9705 prep "1,000",1
R6631 T9708 T9685 punct .,used
R6632 T9710 T9711 det All,images
R6633 T9711 T9712 nsubjpass images,taken
R6634 T9713 T9712 auxpass were,taken
R6635 T9714 T9712 prep with,taken
R6636 T9715 T9716 det a,lens
R6637 T9716 T9714 pobj lens,with
R6638 T9717 T9716 nummod 100,lens
R6639 T9718 T9717 punct ×,100
R6640 T9719 T9716 compound objective,lens
R6641 T9720 T9712 prep under,taken
R6642 T9721 T9722 compound immersion,oil
R6643 T9722 T9720 pobj oil,under
R6644 T9723 T9712 punct .,taken
R6645 T9753 T9754 nmod Metaphase,spermatocyte
R6646 T9754 T9756 compound spermatocyte,spreads
R6647 T9755 T9753 nummod I,Metaphase
R6648 T9757 T9756 cc and,spreads
R6649 T9758 T9759 compound OA,treatment
R6650 T9759 T9756 conj treatment,spreads
R6651 T9760 T9759 punct .,treatment
R6652 T9762 T9763 npadvmod Metaphase,fixed
R6653 T9763 T9764 amod fixed,spermatocytes
R6654 T9764 T9765 nsubj spermatocytes,prepared
R6655 T9766 T9764 prep from,spermatocytes
R6656 T9767 T9768 nummod 8,mo
R6657 T9768 T9770 npadvmod mo,old
R6658 T9769 T9768 punct -,mo
R6659 T9770 T9772 amod old,homozygotes
R6660 T9771 T9770 punct -,old
R6661 T9772 T9766 pobj homozygotes,from
R6662 T9773 T9772 compound Trip13RRB047,homozygotes
R6663 T9774 T9765 punct ", ",prepared
R6664 T9775 T9765 advcl using,prepared
R6665 T9776 T9777 nummod 23,d
R6666 T9777 T9779 npadvmod d,old
R6667 T9778 T9777 punct -,d
R6668 T9779 T9781 amod old,mice
R6669 T9780 T9779 punct -,old
R6670 T9781 T9775 dobj mice,using
R6671 T9782 T9783 amod wild,type
R6672 T9783 T9781 compound type,mice
R6673 T9784 T9783 punct -,type
R6674 T9785 T9775 prep as,using
R6675 T9786 T9785 pobj control,as
R6676 T9787 T9765 punct ", ",prepared
R6677 T9788 T9765 aux were,prepared
R6678 T9789 T9765 cc and,prepared
R6679 T9790 T9765 conj stained,prepared
R6680 T9791 T9790 prep with,stained
R6681 T9792 T9791 pobj Giemsa,with
R6682 T9793 T9794 mark as,described
R6683 T9794 T9765 advcl described,prepared
R6684 T9795 T9796 punct [,64
R6685 T9796 T9765 parataxis 64,prepared
R6686 T9797 T9796 punct ],64
R6687 T9798 T9765 punct .,prepared
R6688 T9800 T9801 prep For,exposed
R6689 T9802 T9803 compound OA,treatment
R6690 T9803 T9800 pobj treatment,For
R6691 T9804 T9801 punct ", ",exposed
R6692 T9805 T9801 nsubjpass cells,exposed
R6693 T9806 T9801 auxpass were,exposed
R6694 T9807 T9801 prep to,exposed
R6695 T9808 T9809 nummod 5,μM
R6696 T9809 T9810 compound μM,OA
R6697 T9810 T9807 pobj OA,to
R6698 T9811 T9812 punct (,Calbiochem
R6699 T9812 T9810 parataxis Calbiochem,OA
R6700 T9813 T9812 punct ", ",Calbiochem
R6701 T9814 T9812 npadvmod http://www.emdbiosciences.com,Calbiochem
R6702 T9815 T9812 punct ),Calbiochem
R6703 T9816 T9801 prep for,exposed
R6704 T9817 T9818 nummod 6,h
R6705 T9818 T9816 pobj h,for
R6706 T9819 T9801 prep at,exposed
R6707 T9820 T9821 nummod 32,°C
R6708 T9821 T9819 pobj °C,at
R6709 T9822 T9801 prep in,exposed
R6710 T9823 T9824 det a,environment
R6711 T9824 T9822 pobj environment,in
R6712 T9825 T9824 amod humidified,environment
R6713 T9826 T9824 prep of,environment
R6714 T9827 T9828 nummod 5,%
R6715 T9828 T9829 compound %,CO2
R6716 T9829 T9826 pobj CO2,of
R6717 T9830 T9801 prep before,exposed
R6718 T9831 T9830 pcomp spreading,before
R6719 T9832 T9833 punct [,65
R6720 T9833 T9801 parataxis 65,exposed
R6721 T9834 T9833 punct ],65
R6722 T9835 T9801 punct .,exposed
R6723 T9837 T9838 det These,preparations
R6724 T9838 T9839 nsubjpass preparations,stained
R6725 T9840 T9839 auxpass were,stained
R6726 T9841 T9839 prep with,stained
R6727 T9842 T9841 pobj DAPI,with
R6728 T9843 T9844 aux to,visualize
R6729 T9844 T9839 advcl visualize,stained
R6730 T9845 T9846 compound metaphase,nuclei
R6731 T9846 T9844 dobj nuclei,visualize
R6732 T9847 T9846 cc and,nuclei
R6733 T9848 T9846 conj chromosomes,nuclei
R6734 T9849 T9839 punct .,stained
R6735 T9864 T9865 amod Phylogenetic,analyses
R6736 T9866 T9865 punct .,analyses
R6737 T9868 T9869 compound TRIP13,orthologs
R6738 T9869 T9870 nsubjpass orthologs,identified
R6739 T9871 T9870 auxpass were,identified
R6740 T9872 T9870 prep by,identified
R6741 T9873 T9874 compound BLASTP,searches
R6742 T9874 T9872 pobj searches,by
R6743 T9875 T9874 prep of,searches
R6744 T9876 T9875 pobj Genbank,of
R6745 T9877 T9876 cc and,Genbank
R6746 T9878 T9879 amod other,sources
R6747 T9879 T9876 conj sources,Genbank
R6748 T9880 T9879 acl providing,sources
R6749 T9881 T9882 compound gene,models
R6750 T9882 T9880 dobj models,providing
R6751 T9883 T9884 amod such,as
R6752 T9884 T9882 prep as,models
R6753 T9885 T9884 pobj Ensembl,as
R6754 T9886 T9870 punct .,identified
R6755 T9888 T9889 det The,orthologs
R6756 T9889 T9891 nsubjpass orthologs,found
R6757 T9890 T9889 amod selected,orthologs
R6758 T9892 T9891 aux can,found
R6759 T9893 T9891 auxpass be,found
R6760 T9894 T9891 prep in,found
R6761 T9895 T9896 compound Table,S1
R6762 T9896 T9894 pobj S1,in
R6763 T9897 T9891 punct .,found
R6764 T9899 T9900 compound Amino,acid
R6765 T9900 T9901 compound acid,alignments
R6766 T9901 T9902 nsubjpass alignments,done
R6767 T9903 T9902 auxpass were,done
R6768 T9904 T9902 prep with,done
R6769 T9905 T9906 compound Clustal,W
R6770 T9906 T9904 pobj W,with
R6771 T9907 T9902 punct ", ",done
R6772 T9908 T9902 advcl using,done
R6773 T9909 T9910 det the,settings
R6774 T9910 T9908 dobj settings,using
R6775 T9911 T9910 compound default,settings
R6776 T9912 T9908 prep with,using
R6777 T9913 T9912 cc and,with
R6778 T9914 T9912 conj without,with
R6779 T9915 T9914 pcomp removing,without
R6780 T9916 T9917 det the,regions
R6781 T9917 T9915 dobj regions,removing
R6782 T9918 T9917 prep outside,regions
R6783 T9919 T9918 prep of,outside
R6784 T9920 T9921 det the,domain
R6785 T9921 T9919 pobj domain,of
R6786 T9922 T9923 nmod AAA,ATPase
R6787 T9923 T9921 nmod ATPase,domain
R6788 T9924 T9923 punct -,ATPase
R6789 T9925 T9921 amod central,domain
R6790 T9926 T9902 punct .,done
R6791 T9928 T9929 det The,trees
R6792 T9929 T9930 nsubjpass trees,constructed
R6793 T9931 T9930 auxpass were,constructed
R6794 T9932 T9930 prep by,constructed
R6795 T9933 T9932 pcomp using,by
R6796 T9934 T9935 det the,method
R6797 T9935 T9933 dobj method,using
R6798 T9936 T9937 npadvmod neighbor,joining
R6799 T9937 T9935 amod joining,method
R6800 T9938 T9937 punct -,joining
R6801 T9939 T9935 prep with,method
R6802 T9940 T9941 compound Poisson,correction
R6803 T9941 T9939 pobj correction,with
R6804 T9942 T9930 punct .,constructed
R6805 T9944 T9945 det The,reliability
R6806 T9945 T9946 nsubjpass reliability,assessed
R6807 T9947 T9945 prep of,reliability
R6808 T9948 T9949 amod internal,branches
R6809 T9949 T9947 pobj branches,of
R6810 T9950 T9946 auxpass was,assessed
R6811 T9951 T9946 prep by,assessed
R6812 T9952 T9951 pcomp using,by
R6813 T9953 T9954 nummod 500,replicates
R6814 T9954 T9952 dobj replicates,using
R6815 T9955 T9954 compound bootstrap,replicates
R6816 T9956 T9946 punct ", ",assessed
R6817 T9957 T9946 cc and,assessed
R6818 T9958 T9959 nsubjpass sites,ignored
R6819 T9959 T9946 conj ignored,assessed
R6820 T9960 T9958 prep with,sites
R6821 T9961 T9960 pobj gaps,with
R6822 T9962 T9959 auxpass were,ignored
R6823 T9963 T9959 prep in,ignored
R6824 T9964 T9965 det this,analysis
R6825 T9965 T9963 pobj analysis,in
R6826 T9966 T9959 punct .,ignored
R6827 T9968 T9969 npadvmod Neighbor,joining
R6828 T9969 T9971 amod joining,searches
R6829 T9970 T9969 punct -,joining
R6830 T9971 T9972 nsubjpass searches,conducted
R6831 T9973 T9972 auxpass were,conducted
R6832 T9974 T9972 prep by,conducted
R6833 T9975 T9974 pcomp using,by
R6834 T9976 T9977 det the,program
R6835 T9977 T9975 dobj program,using
R6836 T9978 T9977 compound computer,program
R6837 T9979 T9977 appos MEGA3,program
R6838 T9980 T9981 punct [,66
R6839 T9981 T9972 parataxis 66,conducted
R6840 T9982 T9981 punct ],66
R6841 T9983 T9972 punct .,conducted
R6842 T10169 T10170 det The,Ortholog
R6843 T10171 T10172 compound Mouse,PCH2
R6844 T10172 T10170 compound PCH2,Ortholog
R6845 T10173 T10170 appos TRIP13,Ortholog
R6846 T10174 T10170 cc and,Ortholog
R6847 T10175 T10170 conj Expression,Ortholog
R6848 T10176 T10175 prep in,Expression
R6849 T10177 T10178 amod Wild,Type
R6850 T10178 T10176 pobj Type,in
R6851 T10179 T10178 cc and,Type
R6852 T10180 T10178 conj Mutant,Type
R6853 T10182 T10183 punct (,A
R6854 T10183 T10184 meta A,tree
R6855 T10185 T10183 punct ),A
R6856 T10186 T10184 amod Phylogenetic,tree
R6857 T10187 T10184 prep of,tree
R6858 T10188 T10189 amod presumed,orthologs
R6859 T10189 T10187 pobj orthologs,of
R6860 T10190 T10191 compound PCH2,TRIP13
R6861 T10191 T10189 compound TRIP13,orthologs
R6862 T10192 T10191 punct /,TRIP13
R6863 T10193 T10184 punct .,tree
R6864 T10195 T10196 det The,number
R6865 T10196 T10200 nsubjpass number,presented
R6866 T10197 T10198 compound database,sequence
R6867 T10198 T10199 compound sequence,accession
R6868 T10199 T10196 compound accession,number
R6869 T10201 T10196 prep of,number
R6870 T10202 T10203 det each,protein
R6871 T10203 T10201 pobj protein,of
R6872 T10204 T10200 auxpass is,presented
R6873 T10205 T10200 prep in,presented
R6874 T10206 T10207 compound Table,S1
R6875 T10207 T10205 pobj S1,in
R6876 T10208 T10200 punct .,presented
R6877 T10210 T10211 nsubj Numbers,are
R6878 T10212 T10210 acl shown,Numbers
R6879 T10213 T10214 compound bootstrap,values
R6880 T10214 T10211 attr values,are
R6881 T10215 T10216 punct (,see
R6882 T10216 T10211 parataxis see,are
R6883 T10217 T10216 dobj Materials,see
R6884 T10218 T10217 cc and,Materials
R6885 T10219 T10217 conj Methods,Materials
R6886 T10220 T10216 punct ),see
R6887 T10221 T10211 punct .,are
R6888 T10223 T10224 det The,clustering
R6889 T10224 T10225 nsubj clustering,was
R6890 T10226 T10227 det the,same
R6891 T10227 T10225 attr same,was
R6892 T10228 T10225 advmod regardless,was
R6893 T10229 T10228 prep of,regardless
R6894 T10230 T10231 mark whether,used
R6895 T10231 T10229 pcomp used,of
R6896 T10232 T10233 det the,sequence
R6897 T10233 T10231 nsubjpass sequence,used
R6898 T10234 T10235 amod whole,entire
R6899 T10235 T10233 amod entire,sequence
R6900 T10236 T10233 compound AA,sequence
R6901 T10237 T10233 cc or,sequence
R6902 T10238 T10239 amod trimmed,sequences
R6903 T10239 T10233 conj sequences,sequence
R6904 T10240 T10239 punct (,sequences
R6905 T10241 T10242 advmod where,removed
R6906 T10242 T10239 relcl removed,sequences
R6907 T10243 T10242 nsubjpass regions,removed
R6908 T10244 T10243 acl showing,regions
R6909 T10245 T10246 amod little,conservation
R6910 T10246 T10244 dobj conservation,showing
R6911 T10247 T10242 auxpass were,removed
R6912 T10248 T10231 punct ),used
R6913 T10249 T10231 auxpass were,used
R6914 T10250 T10231 prep for,used
R6915 T10251 T10252 det the,analysis
R6916 T10252 T10250 pobj analysis,for
R6917 T10253 T10225 punct .,was
R6918 T10255 T10256 amod Major,groups
R6919 T10256 T10258 nsubjpass groups,indicated
R6920 T10257 T10256 amod eukaryotic,groups
R6921 T10259 T10258 auxpass are,indicated
R6922 T10260 T10258 prep in,indicated
R6923 T10261 T10260 pobj color,in
R6924 T10262 T10258 punct ", ",indicated
R6925 T10263 T10264 mark with,in
R6926 T10264 T10258 advcl in,indicated
R6927 T10265 T10264 nsubj deuterostomia,in
R6928 T10266 T10264 pobj blue,in
R6929 T10267 T10264 punct ", ",in
R6930 T10268 T10269 nsubj plants,in
R6931 T10269 T10264 conj in,in
R6932 T10270 T10269 pobj green,in
R6933 T10271 T10269 punct ", ",in
R6934 T10272 T10273 nsubj protostomia,in
R6935 T10273 T10269 conj in,in
R6936 T10274 T10273 pobj purple,in
R6937 T10275 T10273 punct ", ",in
R6938 T10276 T10273 cc and,in
R6939 T10277 T10278 nsubj fungi,in
R6940 T10278 T10273 conj in,in
R6941 T10279 T10278 pobj maroon,in
R6942 T10280 T10258 punct .,indicated
R6943 T10282 T10283 punct (,B
R6944 T10283 T10284 meta B,products
R6945 T10285 T10283 punct ),B
R6946 T10286 T10284 compound Amplification,products
R6947 T10287 T10284 prep of,products
R6948 T10288 T10287 pobj cDNA,of
R6949 T10289 T10284 prep from,products
R6950 T10290 T10291 det the,tissues
R6951 T10291 T10289 pobj tissues,from
R6952 T10292 T10291 amod following,tissues
R6953 T10293 T10291 punct : ,tissues
R6954 T10294 T10295 meta 1,heart
R6955 T10295 T10291 appos heart,tissues
R6956 T10296 T10295 punct ", ",heart
R6957 T10297 T10295 punct ;,heart
R6958 T10298 T10299 meta 2,brain
R6959 T10299 T10295 conj brain,heart
R6960 T10300 T10299 punct ", ",brain
R6961 T10301 T10299 punct ;,brain
R6962 T10302 T10303 meta 3,spleen
R6963 T10303 T10299 conj spleen,brain
R6964 T10304 T10303 punct ", ",spleen
R6965 T10305 T10303 punct ;,spleen
R6966 T10306 T10307 meta 4,lung
R6967 T10307 T10303 conj lung,spleen
R6968 T10308 T10307 punct ", ",lung
R6969 T10309 T10307 punct ;,lung
R6970 T10310 T10311 meta 5,liver
R6971 T10311 T10307 conj liver,lung
R6972 T10312 T10311 punct ", ",liver
R6973 T10313 T10311 punct ;,liver
R6974 T10314 T10315 meta 6,muscle
R6975 T10315 T10311 conj muscle,liver
R6976 T10316 T10315 punct ", ",muscle
R6977 T10317 T10315 amod skeletal,muscle
R6978 T10318 T10315 punct ;,muscle
R6979 T10319 T10320 meta 7,kidney
R6980 T10320 T10315 conj kidney,muscle
R6981 T10321 T10320 punct ", ",kidney
R6982 T10322 T10320 punct ;,kidney
R6983 T10323 T10324 meta 8,testis
R6984 T10324 T10320 conj testis,kidney
R6985 T10325 T10324 punct ", ",testis
R6986 T10326 T10324 punct ;,testis
R6987 T10327 T10328 meta 9,embryo
R6988 T10328 T10324 conj embryo,testis
R6989 T10329 T10328 punct ", ",embryo
R6990 T10330 T10328 compound E7,embryo
R6991 T10331 T10328 punct ;,embryo
R6992 T10332 T10333 meta 10,embryo
R6993 T10333 T10328 conj embryo,embryo
R6994 T10334 T10333 punct ", ",embryo
R6995 T10335 T10333 compound E11,embryo
R6996 T10336 T10333 punct ;,embryo
R6997 T10337 T10338 meta 11,embryo
R6998 T10338 T10333 conj embryo,embryo
R6999 T10339 T10338 punct ", ",embryo
R7000 T10340 T10338 compound E15,embryo
R7001 T10341 T10338 punct ;,embryo
R7002 T10342 T10338 cc and,embryo
R7003 T10343 T10344 meta 12,embryo
R7004 T10344 T10338 conj embryo,embryo
R7005 T10345 T10344 punct ", ",embryo
R7006 T10346 T10344 compound E17,embryo
R7007 T10347 T10284 punct .,products
R7008 T10349 T10350 punct (,C
R7009 T10350 T10351 meta C,structure
R7010 T10352 T10350 punct ),C
R7011 T10353 T10354 compound Intron,exon
R7012 T10354 T10351 compound exon,structure
R7013 T10355 T10354 punct –,exon
R7014 T10356 T10351 prep of,structure
R7015 T10357 T10356 pobj TRIP13,of
R7016 T10358 T10351 cc and,structure
R7017 T10359 T10360 compound insertion,site
R7018 T10360 T10351 conj site,structure
R7019 T10361 T10360 prep of,site
R7020 T10362 T10363 compound gene,trap
R7021 T10363 T10365 compound trap,vector
R7022 T10364 T10363 punct -,trap
R7023 T10365 T10361 pobj vector,of
R7024 T10366 T10360 punct .,site
R7025 T10369 T10368 dobj Materials,See
R7026 T10370 T10369 cc and,Materials
R7027 T10371 T10369 conj Methods,Materials
R7028 T10372 T10368 prep for,See
R7029 T10373 T10372 pobj details,for
R7030 T10374 T10373 prep on,details
R7031 T10375 T10376 advmod how,identified
R7032 T10376 T10374 pcomp identified,on
R7033 T10377 T10378 det the,site
R7034 T10378 T10376 nsubjpass site,identified
R7035 T10379 T10378 amod precise,site
R7036 T10380 T10378 compound insertion,site
R7037 T10381 T10376 auxpass was,identified
R7038 T10382 T10368 punct .,See
R7039 T10384 T10385 punct (,D
R7040 T10385 T10386 meta D,PCR
R7041 T10387 T10385 punct ),D
R7042 T10388 T10386 compound RT,PCR
R7043 T10389 T10386 punct -,PCR
R7044 T10390 T10386 prep of,PCR
R7045 T10391 T10390 pobj Trip13,of
R7046 T10392 T10391 cc and,Trip13
R7047 T10393 T10394 det a,Med31
R7048 T10394 T10391 conj Med31,Trip13
R7049 T10395 T10394 compound control,Med31
R7050 T10396 T10394 compound gene,Med31
R7051 T10397 T10394 prep from,Med31
R7052 T10398 T10399 compound testis,RNA
R7053 T10399 T10397 pobj RNA,from
R7054 T10400 T10386 punct .,PCR
R7055 T10402 T10403 det The,primers
R7056 T10403 T10405 nsubjpass primers,situated
R7057 T10404 T10403 compound Trip13,primers
R7058 T10406 T10405 auxpass are,situated
R7059 T10407 T10405 prep in,situated
R7060 T10408 T10409 det the,exons
R7061 T10409 T10407 pobj exons,in
R7062 T10410 T10409 amod first,exons
R7063 T10411 T10410 cc and,first
R7064 T10412 T10410 conj last,first
R7065 T10413 T10414 punct (,see
R7066 T10414 T10405 parataxis see,situated
R7067 T10415 T10414 dobj Materials,see
R7068 T10416 T10415 cc and,Materials
R7069 T10417 T10415 conj Methods,Materials
R7070 T10418 T10414 punct ),see
R7071 T10419 T10405 punct .,situated
R7072 T10421 T10422 punct (,E
R7073 T10422 T10423 meta E,analysis
R7074 T10424 T10422 punct ),E
R7075 T10425 T10426 compound Western,blot
R7076 T10426 T10423 compound blot,analysis
R7077 T10427 T10423 prep of,analysis
R7078 T10428 T10429 compound testis,protein
R7079 T10429 T10427 pobj protein,of
R7080 T10430 T10423 prep with,analysis
R7081 T10431 T10432 amod anti-TRIP13,antibody
R7082 T10432 T10430 pobj antibody,with
R7083 T10433 T10423 punct .,analysis
R7084 T10435 T10436 det The,blot
R7085 T10436 T10437 nsubjpass blot,probed
R7086 T10438 T10437 auxpass was,probed
R7087 T10439 T10437 advmod later,probed
R7088 T10440 T10437 prep with,probed
R7089 T10441 T10442 amod anti-alpha,actin
R7090 T10442 T10440 pobj actin,with
R7091 T10443 T10442 compound tubulin,actin
R7092 T10444 T10442 prep as,actin
R7093 T10445 T10446 det a,control
R7094 T10446 T10444 pobj control,as
R7095 T10447 T10446 compound loading,control
R7096 T10448 T10437 punct .,probed
R7097 T10450 T10451 det The,protein
R7098 T10451 T10454 nsubj protein,is
R7099 T10452 T10451 amod expected,protein
R7100 T10453 T10451 compound TRIP13,protein
R7101 T10455 T10456 punct ∼,48
R7102 T10456 T10457 nummod 48,KDa
R7103 T10457 T10454 attr KDa,is
R7104 T10458 T10454 punct .,is
R7105 T10460 T10461 punct (,F
R7106 T10461 T10462 meta F,Localization
R7107 T10463 T10461 punct ),F
R7108 T10464 T10462 prep of,Localization
R7109 T10465 T10464 pobj TRIP13,of
R7110 T10466 T10462 prep in,Localization
R7111 T10467 T10466 pobj testes,in
R7112 T10468 T10462 punct .,Localization
R7113 T10470 T10471 amod Wild,type
R7114 T10471 T10473 nmod type,testis
R7115 T10472 T10471 punct -,type
R7116 T10473 T10482 compound testis,sections
R7117 T10474 T10475 punct (,top
R7118 T10475 T10471 parataxis top,type
R7119 T10476 T10475 punct ),top
R7120 T10477 T10471 cc and,type
R7121 T10478 T10471 conj mutant,type
R7122 T10479 T10480 punct (,bottom
R7123 T10480 T10478 parataxis bottom,mutant
R7124 T10481 T10480 punct ),bottom
R7125 T10482 T10483 nsubjpass sections,probed
R7126 T10484 T10483 auxpass were,probed
R7127 T10485 T10483 prep with,probed
R7128 T10486 T10485 pobj chicken,with
R7129 T10487 T10486 amod anti-TRIP13,chicken
R7130 T10488 T10483 punct ", ",probed
R7131 T10489 T10483 cc and,probed
R7132 T10490 T10483 conj detected,probed
R7133 T10491 T10490 prep with,detected
R7134 T10492 T10493 npadvmod HRP,conjugated
R7135 T10493 T10495 amod conjugated,IgG
R7136 T10494 T10493 punct -,conjugated
R7137 T10495 T10491 pobj IgG,with
R7138 T10496 T10495 amod anti-chicken,IgG
R7139 T10497 T10498 punct (,staining
R7140 T10498 T10495 parataxis staining,IgG
R7141 T10499 T10500 amod brown,red
R7142 T10500 T10498 amod red,staining
R7143 T10501 T10500 punct /,red
R7144 T10502 T10498 punct ),staining
R7145 T10503 T10483 punct .,probed
R7146 T10505 T10506 nsubj Expression,was
R7147 T10507 T10505 prep in,Expression
R7148 T10508 T10507 pobj WT,in
R7149 T10509 T10510 advmod most,prominent
R7150 T10510 T10506 acomp prominent,was
R7151 T10511 T10506 prep in,was
R7152 T10512 T10513 det the,nuclei
R7153 T10513 T10511 pobj nuclei,in
R7154 T10514 T10513 prep of,nuclei
R7155 T10515 T10516 compound Type,B
R7156 T10516 T10517 compound B,spermatogonia
R7157 T10517 T10514 pobj spermatogonia,of
R7158 T10518 T10517 punct (,spermatogonia
R7159 T10519 T10517 appos Sg,spermatogonia
R7160 T10520 T10517 punct ),spermatogonia
R7161 T10521 T10517 punct ", ",spermatogonia
R7162 T10522 T10523 compound leptotene,spermatocytes
R7163 T10523 T10517 conj spermatocytes,spermatogonia
R7164 T10524 T10523 punct (,spermatocytes
R7165 T10525 T10523 appos LS,spermatocytes
R7166 T10526 T10523 punct ),spermatocytes
R7167 T10527 T10523 punct ", ",spermatocytes
R7168 T10528 T10523 cc and,spermatocytes
R7169 T10529 T10530 amod early,spermatocytes
R7170 T10530 T10523 conj spermatocytes,spermatocytes
R7171 T10531 T10530 compound pachytene,spermatocytes
R7172 T10532 T10530 punct (,spermatocytes
R7173 T10533 T10530 appos PS,spermatocytes
R7174 T10534 T10530 punct ),spermatocytes
R7175 T10535 T10530 punct ", ",spermatocytes
R7176 T10536 T10530 cc but,spermatocytes
R7177 T10537 T10536 neg not,but
R7178 T10538 T10539 amod late,spermatocytes
R7179 T10539 T10530 conj spermatocytes,spermatocytes
R7180 T10540 T10539 compound pachytene,spermatocytes
R7181 T10541 T10539 punct (,spermatocytes
R7182 T10542 T10539 appos LP,spermatocytes
R7183 T10543 T10506 punct ),was
R7184 T10544 T10506 punct .,was
R7185 T10546 T10547 det No,staining
R7186 T10547 T10549 nsubjpass staining,seen
R7187 T10548 T10547 amod nuclear,staining
R7188 T10550 T10549 auxpass was,seen
R7189 T10551 T10549 prep in,seen
R7190 T10552 T10553 compound mutant,sections
R7191 T10553 T10551 pobj sections,in
R7192 T10554 T10553 compound testis,sections
R7193 T10555 T10549 punct ", ",seen
R7194 T10556 T10557 mark although,is
R7195 T10557 T10549 advcl is,seen
R7196 T10558 T10559 amod reddish,background
R7197 T10559 T10557 nsubj background,is
R7198 T10560 T10559 amod cytoplasmic,background
R7199 T10561 T10557 acomp present,is
R7200 T10562 T10549 punct .,seen
R7201 T10564 T10565 nsubjpass Identification,judged
R7202 T10566 T10564 prep of,Identification
R7203 T10567 T10568 compound cell,types
R7204 T10568 T10566 pobj types,of
R7205 T10569 T10565 auxpass was,judged
R7206 T10570 T10565 prep in,judged
R7207 T10571 T10570 amod part,in
R7208 T10572 T10565 prep by,judged
R7209 T10573 T10572 pcomp estimating,by
R7210 T10574 T10575 det the,stage
R7211 T10575 T10573 dobj stage,estimating
R7212 T10576 T10575 amod epithelial,stage
R7213 T10577 T10575 prep of,stage
R7214 T10578 T10579 det the,tubules
R7215 T10579 T10577 pobj tubules,of
R7216 T10580 T10581 mark as,described
R7217 T10581 T10573 advcl described,estimating
R7218 T10582 T10583 punct [,67
R7219 T10583 T10573 parataxis 67,estimating
R7220 T10584 T10583 punct ],67
R7221 T10585 T10565 punct .,judged
R7222 T10587 T10588 punct (,G
R7223 T10588 T10589 meta G,localization
R7224 T10590 T10588 punct ),G
R7225 T10591 T10589 compound TRIP13,localization
R7226 T10592 T10589 prep in,localization
R7227 T10593 T10594 compound surface,spread
R7228 T10594 T10596 compound spread,spermatocytes
R7229 T10595 T10594 punct -,spread
R7230 T10596 T10592 pobj spermatocytes,in
R7231 T10597 T10589 punct .,localization
R7232 T10599 T10600 nsubjpass Preparations,immunolabeled
R7233 T10601 T10600 auxpass were,immunolabeled
R7234 T10602 T10600 prep with,immunolabeled
R7235 T10603 T10602 pobj anti-SYCP3,with
R7236 T10604 T10603 punct (,anti-SYCP3
R7237 T10605 T10603 appos S,anti-SYCP3
R7238 T10606 T10603 punct ),anti-SYCP3
R7239 T10607 T10603 cc and,anti-SYCP3
R7240 T10608 T10603 conj TRIP13,anti-SYCP3
R7241 T10609 T10608 punct (,TRIP13
R7242 T10610 T10608 appos T,TRIP13
R7243 T10611 T10600 punct ),immunolabeled
R7244 T10612 T10600 punct .,immunolabeled
R7245 T10614 T10615 preconj Both,individual
R7246 T10615 T10616 amod individual,images
R7247 T10616 T10619 nsubjpass images,shown
R7248 T10617 T10615 cc and,individual
R7249 T10618 T10615 conj merged,individual
R7250 T10620 T10619 auxpass are,shown
R7251 T10621 T10619 prep for,shown
R7252 T10622 T10623 nmod leptotene,spermatocytes
R7253 T10623 T10621 pobj spermatocytes,for
R7254 T10624 T10622 punct (,leptotene
R7255 T10625 T10622 appos Lep,leptotene
R7256 T10626 T10622 punct ),leptotene
R7257 T10627 T10622 punct ", ",leptotene
R7258 T10628 T10622 conj zygotene,leptotene
R7259 T10629 T10628 punct (,zygotene
R7260 T10630 T10628 appos Zyg,zygotene
R7261 T10631 T10628 punct ),zygotene
R7262 T10632 T10628 punct ", ",zygotene
R7263 T10633 T10628 cc and,zygotene
R7264 T10634 T10628 conj pachytene,zygotene
R7265 T10635 T10634 punct (,pachytene
R7266 T10636 T10634 appos Pac,pachytene
R7267 T10637 T10623 punct ),spermatocytes
R7268 T10638 T10619 punct .,shown
R7269 T10640 T10641 amod Nuclear,staining
R7270 T10641 T10642 nsubj staining,was
R7271 T10643 T10642 acomp absent,was
R7272 T10644 T10642 prep in,was
R7273 T10645 T10646 det the,mutant
R7274 T10646 T10644 pobj mutant,in
R7275 T10647 T10642 punct .,was
R7276 T10698 T10699 amod Developmental,Phenotypes
R7277 T10700 T10699 prep of,Phenotypes
R7278 T10701 T10702 compound Trip13,Mutant
R7279 T10702 T10703 compound Mutant,Mice
R7280 T10703 T10700 pobj Mice,of
R7281 T10705 T10706 punct (,A
R7282 T10706 T10707 meta A,are
R7283 T10708 T10706 punct ),A
R7284 T10709 T10707 dep Shown,are
R7285 T10710 T10711 nummod 21,d
R7286 T10711 T10713 npadvmod d,old
R7287 T10712 T10711 punct -,d
R7288 T10713 T10715 amod old,littermates
R7289 T10714 T10713 punct -,old
R7290 T10715 T10707 nsubj littermates,are
R7291 T10716 T10707 punct .,are
R7292 T10719 T10720 det the,tail
R7293 T10720 T10718 dobj tail,Note
R7294 T10721 T10720 amod shortened,tail
R7295 T10722 T10720 prep in,tail
R7296 T10723 T10724 det the,mutant
R7297 T10724 T10722 pobj mutant,in
R7298 T10725 T10720 punct ", ",tail
R7299 T10726 T10720 cc but,tail
R7300 T10727 T10728 amod overall,similar
R7301 T10728 T10729 amod similar,size
R7302 T10729 T10720 conj size,tail
R7303 T10730 T10729 compound body,size
R7304 T10731 T10718 punct .,Note
R7305 T10733 T10734 punct (,B
R7306 T10734 T10735 meta B,are
R7307 T10736 T10734 punct ),B
R7308 T10737 T10735 dep Shown,are
R7309 T10738 T10739 nummod 23,d
R7310 T10739 T10741 npadvmod d,old
R7311 T10740 T10739 punct -,d
R7312 T10741 T10743 amod old,littermates
R7313 T10742 T10741 punct -,old
R7314 T10743 T10735 nsubj littermates,are
R7315 T10744 T10735 punct .,are
R7316 T10746 T10747 det The,mutant
R7317 T10747 T10748 nsubj mutant,is
R7318 T10749 T10748 acomp smaller,is
R7319 T10750 T10748 prep in,is
R7320 T10751 T10752 det this,case
R7321 T10752 T10750 pobj case,in
R7322 T10753 T10748 punct ", ",is
R7323 T10754 T10748 cc but,is
R7324 T10755 T10756 det the,tail
R7325 T10756 T10757 nsubj tail,is
R7326 T10757 T10748 conj is,is
R7327 T10758 T10757 neg not,is
R7328 T10759 T10760 advmod as,truncated
R7329 T10760 T10757 acomp truncated,is
R7330 T10761 T10760 prep as,truncated
R7331 T10762 T10763 det the,mouse
R7332 T10763 T10761 pobj mouse,as
R7333 T10764 T10763 prep in,mouse
R7334 T10765 T10766 punct (,A
R7335 T10766 T10764 pobj A,in
R7336 T10767 T10766 punct ),A
R7337 T10768 T10757 punct .,is
R7338 T10770 T10771 punct (,C
R7339 T10771 T10772 meta C,testes
R7340 T10773 T10771 punct ),C
R7341 T10774 T10775 amod Wild,type
R7342 T10775 T10772 nmod type,testes
R7343 T10776 T10775 punct -,type
R7344 T10777 T10775 punct (,type
R7345 T10778 T10775 appos WT,type
R7346 T10779 T10775 punct ),type
R7347 T10780 T10775 cc and,type
R7348 T10781 T10782 amod homozygous,mutant
R7349 T10782 T10775 conj mutant,type
R7350 T10783 T10782 compound Trip13,mutant
R7351 T10784 T10782 punct (,mutant
R7352 T10785 T10782 appos MUT,mutant
R7353 T10786 T10772 punct ),testes
R7354 T10787 T10772 punct .,testes
R7355 T10789 T10790 punct (,D
R7356 T10790 T10791 nsubj D,are
R7357 T10792 T10790 punct ),D
R7358 T10793 T10790 cc and,D
R7359 T10794 T10795 punct (,E
R7360 T10795 T10790 conj E,D
R7361 T10796 T10795 punct ),E
R7362 T10797 T10798 compound cross,sections
R7363 T10798 T10791 attr sections,are
R7364 T10799 T10798 prep through,sections
R7365 T10800 T10801 nummod 17.5,d
R7366 T10801 T10803 npadvmod d,old
R7367 T10802 T10801 punct -,d
R7368 T10803 T10805 amod old,testes
R7369 T10804 T10803 punct -,old
R7370 T10805 T10799 pobj testes,through
R7371 T10806 T10807 amod heterozygous,mutant
R7372 T10807 T10805 compound mutant,testes
R7373 T10808 T10809 punct (,WT
R7374 T10809 T10806 parataxis WT,heterozygous
R7375 T10810 T10809 punct “,WT
R7376 T10811 T10809 punct ”,WT
R7377 T10812 T10809 punct ),WT
R7378 T10813 T10806 cc and,heterozygous
R7379 T10814 T10806 conj homozygous,heterozygous
R7380 T10815 T10805 compound Trip13,testes
R7381 T10816 T10791 punct ", ",are
R7382 T10817 T10791 advmod respectively,are
R7383 T10818 T10791 punct .,are
R7384 T10820 T10821 mark Whereas,show
R7385 T10821 T10826 advcl show,synchronized
R7386 T10822 T10823 det the,tubules
R7387 T10823 T10821 nsubj tubules,show
R7388 T10824 T10823 prep in,tubules
R7389 T10825 T10824 pobj WT,in
R7390 T10827 T10828 amod coordinated,spermatogenesis
R7391 T10828 T10821 dobj spermatogenesis,show
R7392 T10829 T10828 prep with,spermatogenesis
R7393 T10830 T10831 compound pachytene,spermatocytes
R7394 T10831 T10829 pobj spermatocytes,with
R7395 T10832 T10831 relcl present,spermatocytes
R7396 T10833 T10832 prep in,present
R7397 T10834 T10835 det all,tubules
R7398 T10835 T10833 pobj tubules,in
R7399 T10836 T10835 punct (,tubules
R7400 T10837 T10835 amod proximal,tubules
R7401 T10838 T10837 prep to,proximal
R7402 T10839 T10840 det the,lumen
R7403 T10840 T10838 pobj lumen,to
R7404 T10841 T10826 punct ),synchronized
R7405 T10842 T10826 punct ", ",synchronized
R7406 T10843 T10844 amod developmental,progression
R7407 T10844 T10826 nsubjpass progression,synchronized
R7408 T10845 T10844 prep in,progression
R7409 T10846 T10847 det the,mutant
R7410 T10847 T10845 pobj mutant,in
R7411 T10848 T10826 auxpass is,synchronized
R7412 T10849 T10826 neg not,synchronized
R7413 T10850 T10826 prep between,synchronized
R7414 T10851 T10850 pobj tubules,between
R7415 T10852 T10826 punct .,synchronized
R7416 T10854 T10855 det Some,tubules
R7417 T10855 T10856 nsubj tubules,have
R7418 T10857 T10858 det no,spermatocyes
R7419 T10858 T10856 dobj spermatocyes,have
R7420 T10859 T10858 compound pachytene,spermatocyes
R7421 T10860 T10861 punct (,asterisks
R7422 T10861 T10858 parataxis asterisks,spermatocyes
R7423 T10862 T10861 punct ),asterisks
R7424 T10863 T10856 punct ", ",have
R7425 T10864 T10865 mark while,is
R7426 T10865 T10856 advcl is,have
R7427 T10866 T10865 prep in,is
R7428 T10867 T10866 pobj others,in
R7429 T10868 T10865 punct ", ",is
R7430 T10869 T10865 nsubj development,is
R7431 T10870 T10871 advmod somewhat,disorganized
R7432 T10871 T10865 acomp disorganized,is
R7433 T10872 T10873 punct (,#
R7434 T10873 T10865 punct #,is
R7435 T10874 T10873 punct ),#
R7436 T10875 T10856 punct .,have
R7437 T11058 T11057 prep of,Histology
R7438 T11059 T11060 compound Mutant,Gonads
R7439 T11060 T11058 pobj Gonads,of
R7440 T11062 T11063 nsubj All,are
R7441 T11064 T11065 compound hematoxylin,eosin
R7442 T11065 T11067 npadvmod eosin,stained
R7443 T11066 T11065 punct /,eosin
R7444 T11067 T11069 amod stained,sections
R7445 T11068 T11067 punct -,stained
R7446 T11069 T11063 attr sections,are
R7447 T11070 T11069 compound paraffin,sections
R7448 T11071 T11063 punct .,are
R7449 T11073 T11074 nsubj Testes,are
R7450 T11075 T11074 prep from,are
R7451 T11076 T11077 nummod 6,wk
R7452 T11077 T11079 npadvmod wk,old
R7453 T11078 T11077 punct -,wk
R7454 T11079 T11081 amod old,males
R7455 T11080 T11079 punct -,old
R7456 T11081 T11075 pobj males,from
R7457 T11082 T11074 punct ", ",are
R7458 T11083 T11074 prep except,are
R7459 T11084 T11085 mark as,indicated
R7460 T11085 T11083 pcomp indicated,except
R7461 T11086 T11085 advmod below,indicated
R7462 T11087 T11074 punct .,are
R7463 T11089 T11090 punct (,A
R7464 T11090 T11091 meta A,ovary
R7465 T11092 T11090 punct ),A
R7466 T11093 T11094 amod Wild,type
R7467 T11094 T11091 nmod type,ovary
R7468 T11095 T11094 punct -,type
R7469 T11096 T11097 nummod 25,d
R7470 T11097 T11099 npadvmod d,old
R7471 T11098 T11097 punct -,d
R7472 T11099 T11091 amod old,ovary
R7473 T11100 T11099 punct -,old
R7474 T11101 T11091 punct .,ovary
R7475 T11103 T11104 punct (,B
R7476 T11104 T11105 meta B,ovary
R7477 T11106 T11104 punct ),B
R7478 T11107 T11108 nmod Trip13Gt,Gt
R7479 T11108 T11105 nmod Gt,ovary
R7480 T11109 T11108 punct /,Gt
R7481 T11110 T11111 nummod 25,d
R7482 T11111 T11113 npadvmod d,old
R7483 T11112 T11111 punct -,d
R7484 T11113 T11105 amod old,ovary
R7485 T11114 T11113 punct -,old
R7486 T11115 T11105 punct ", ",ovary
R7487 T11116 T11105 acl showing,ovary
R7488 T11117 T11116 dobj dysgenesis,showing
R7489 T11118 T11117 prep from,dysgenesis
R7490 T11119 T11120 det an,absence
R7491 T11120 T11118 pobj absence,from
R7492 T11121 T11120 prep of,absence
R7493 T11122 T11121 pobj oocytes,of
R7494 T11123 T11105 punct .,ovary
R7495 T11125 T11126 punct (,C
R7496 T11126 T11127 meta C,ovary
R7497 T11128 T11126 punct ),C
R7498 T11129 T11127 nmod Trip13Gt,ovary
R7499 T11130 T11129 punct /,Trip13Gt
R7500 T11131 T11129 punct +,Trip13Gt
R7501 T11132 T11133 nummod 2,d
R7502 T11133 T11135 npadvmod d,old
R7503 T11134 T11133 punct -,d
R7504 T11135 T11127 amod old,ovary
R7505 T11136 T11135 punct -,old
R7506 T11137 T11127 compound control,ovary
R7507 T11138 T11127 punct .,ovary
R7508 T11140 T11141 nsubj Arrows,point
R7509 T11142 T11141 prep to,point
R7510 T11143 T11142 pobj oocytes,to
R7511 T11144 T11143 prep in,oocytes
R7512 T11145 T11146 advmod newly,forming
R7513 T11146 T11147 amod forming,follicles
R7514 T11147 T11144 pobj follicles,in
R7515 T11148 T11141 punct .,point
R7516 T11150 T11151 punct (,D
R7517 T11151 T11152 meta D,ovary
R7518 T11153 T11151 punct ),D
R7519 T11154 T11155 nmod Trip13Gt,Gt
R7520 T11155 T11152 nmod Gt,ovary
R7521 T11156 T11155 punct /,Gt
R7522 T11157 T11158 nummod 2,d
R7523 T11158 T11160 npadvmod d,old
R7524 T11159 T11158 punct -,d
R7525 T11160 T11152 amod old,ovary
R7526 T11161 T11160 punct -,old
R7527 T11162 T11152 punct ", ",ovary
R7528 T11163 T11152 relcl dysgenic,ovary
R7529 T11164 T11163 prep due,dysgenic
R7530 T11165 T11164 pcomp to,due
R7531 T11166 T11164 pobj lack,due
R7532 T11167 T11166 prep of,lack
R7533 T11168 T11167 pobj oocytes,of
R7534 T11169 T11152 punct .,ovary
R7535 T11171 T11172 nsubj Magnification,is
R7536 T11173 T11174 det the,same
R7537 T11174 T11172 attr same,is
R7538 T11175 T11174 prep as,same
R7539 T11176 T11177 poss its,littermate
R7540 T11177 T11175 pobj littermate,as
R7541 T11178 T11177 prep in,littermate
R7542 T11179 T11180 punct “,C.
R7543 T11180 T11178 pobj C.,in
R7544 T11181 T11172 punct ”,is
R7545 T11183 T11184 punct (,E
R7546 T11184 T11185 meta E,testis
R7547 T11186 T11184 punct ),E
R7548 T11187 T11188 amod Wild,type
R7549 T11188 T11185 compound type,testis
R7550 T11189 T11188 punct -,type
R7551 T11190 T11185 punct .,testis
R7552 T11192 T11193 punct (,F
R7553 T11193 T11194 meta F,testis
R7554 T11195 T11193 punct ),F
R7555 T11196 T11197 compound Trip13Gt,Gt
R7556 T11197 T11194 compound Gt,testis
R7557 T11198 T11197 punct /,Gt
R7558 T11199 T11194 prep with,testis
R7559 T11200 T11201 amod uniform,arrest
R7560 T11201 T11199 pobj arrest,with
R7561 T11202 T11201 compound pachytene,arrest
R7562 T11203 T11194 punct .,testis
R7563 T11205 T11206 punct (,G
R7564 T11206 T11207 meta G,testis
R7565 T11208 T11206 punct ),G
R7566 T11209 T11210 nmod Trip13Gt,Gt
R7567 T11210 T11207 nmod Gt,testis
R7568 T11211 T11210 punct /,Gt
R7569 T11212 T11213 nummod 3,mo
R7570 T11213 T11215 npadvmod mo,old
R7571 T11214 T11213 punct -,mo
R7572 T11215 T11207 amod old,testis
R7573 T11216 T11215 punct -,old
R7574 T11217 T11207 prep with,testis
R7575 T11218 T11219 det some,spermatids
R7576 T11219 T11217 pobj spermatids,with
R7577 T11220 T11219 amod postmeiotic,spermatids
R7578 T11221 T11222 punct (,arrows
R7579 T11222 T11219 parataxis arrows,spermatids
R7580 T11223 T11222 punct ),arrows
R7581 T11224 T11207 punct .,testis
R7582 T11226 T11227 punct (,H
R7583 T11227 T11228 meta H,testis
R7584 T11229 T11227 punct ),H
R7585 T11230 T11228 nmod Spo11,testis
R7586 T11231 T11230 punct −,Spo11
R7587 T11232 T11230 punct /,Spo11
R7588 T11233 T11230 punct -,Spo11
R7589 T11234 T11228 punct .,testis
R7590 T11236 T11237 det A,tubule
R7591 T11237 T11238 nsubjpass tubule,labeled
R7592 T11239 T11237 prep with,tubule
R7593 T11240 T11239 pobj spermatocytes,with
R7594 T11241 T11240 prep at,spermatocytes
R7595 T11242 T11243 compound leptotene,zygotene
R7596 T11243 T11245 compound zygotene,transition
R7597 T11244 T11243 punct /,zygotene
R7598 T11245 T11241 pobj transition,at
R7599 T11246 T11238 auxpass is,labeled
R7600 T11247 T11238 oprd ZP,labeled
R7601 T11248 T11238 punct ", ",labeled
R7602 T11249 T11238 cc and,labeled
R7603 T11250 T11251 nsubjpass tubules,marked
R7604 T11251 T11238 conj marked,labeled
R7605 T11252 T11250 prep with,tubules
R7606 T11253 T11254 amod apoptotic,spermatocytes
R7607 T11254 T11252 pobj spermatocytes,with
R7608 T11255 T11251 auxpass are,marked
R7609 T11256 T11251 prep with,marked
R7610 T11257 T11258 det an,asterisk
R7611 T11258 T11256 pobj asterisk,with
R7612 T11259 T11251 punct .,marked
R7613 T11261 T11262 det The,specimen
R7614 T11262 T11263 nsubjpass specimen,taken
R7615 T11264 T11263 auxpass was,taken
R7616 T11265 T11263 prep from,taken
R7617 T11266 T11267 det a,littermate
R7618 T11267 T11265 pobj littermate,from
R7619 T11268 T11267 prep of,littermate
R7620 T11269 T11268 pobj that,of
R7621 T11270 T11269 prep in,that
R7622 T11271 T11272 punct (,I
R7623 T11272 T11270 pobj I,in
R7624 T11273 T11272 punct ),I
R7625 T11274 T11263 punct .,taken
R7626 T11276 T11277 punct (,I
R7627 T11277 T11278 meta I,testis
R7628 T11279 T11277 punct ),I
R7629 T11280 T11278 nmod Spo11,testis
R7630 T11281 T11280 punct −,Spo11
R7631 T11282 T11280 punct /,Spo11
R7632 T11283 T11280 punct −,Spo11
R7633 T11284 T11285 compound Trip13Gt,Gt
R7634 T11285 T11278 compound Gt,testis
R7635 T11286 T11285 punct /,Gt
R7636 T11287 T11278 punct .,testis
R7637 T11289 T11290 nsubj Labeling,is
R7638 T11291 T11292 advmod the,same
R7639 T11292 T11290 acomp same,is
R7640 T11293 T11292 prep as,same
R7641 T11294 T11293 prep in,as
R7642 T11295 T11296 punct (,H
R7643 T11296 T11294 pobj H,in
R7644 T11297 T11296 punct ),H
R7645 T11298 T11290 punct .,is
R7646 T11300 T11301 det The,inset
R7647 T11301 T11302 nsubj inset,contains
R7648 T11303 T11304 det a,tubule
R7649 T11304 T11302 dobj tubule,contains
R7650 T11305 T11304 prep with,tubule
R7651 T11306 T11307 compound leptotene,zygotene
R7652 T11307 T11309 compound zygotene,spermatocytes
R7653 T11308 T11307 punct -,zygotene
R7654 T11309 T11305 pobj spermatocytes,with
R7655 T11310 T11302 punct .,contains
R7656 T11312 T11313 punct (,J
R7657 T11313 T11314 meta J,testis
R7658 T11315 T11313 punct ),J
R7659 T11316 T11314 nmod Mei1,testis
R7660 T11317 T11316 punct −,Mei1
R7661 T11318 T11316 punct /,Mei1
R7662 T11319 T11316 punct −,Mei1
R7663 T11320 T11314 nmod Trip13Gt,testis
R7664 T11321 T11320 punct /,Trip13Gt
R7665 T11322 T11320 punct +,Trip13Gt
R7666 T11323 T11314 punct .,testis
R7667 T11325 T11326 det The,specimen
R7668 T11326 T11327 nsubjpass specimen,taken
R7669 T11328 T11327 auxpass was,taken
R7670 T11329 T11327 prep from,taken
R7671 T11330 T11331 det a,littermate
R7672 T11331 T11329 pobj littermate,from
R7673 T11332 T11331 prep of,littermate
R7674 T11333 T11332 pobj that,of
R7675 T11334 T11333 prep in,that
R7676 T11335 T11336 punct (,K
R7677 T11336 T11334 pobj K,in
R7678 T11337 T11336 punct ),K
R7679 T11338 T11327 punct .,taken
R7680 T11340 T11341 punct (,K
R7681 T11341 T11342 meta K,testis
R7682 T11343 T11341 punct ),K
R7683 T11344 T11342 nmod Mei1,testis
R7684 T11345 T11344 punct −,Mei1
R7685 T11346 T11344 punct /,Mei1
R7686 T11347 T11344 punct −,Mei1
R7687 T11348 T11349 compound Trip13Gt,Gt
R7688 T11349 T11342 compound Gt,testis
R7689 T11350 T11349 punct /,Gt
R7690 T11351 T11342 punct .,testis
R7691 T11353 T11354 punct (,L
R7692 T11354 T11355 meta L,testis
R7693 T11356 T11354 punct ),L
R7694 T11357 T11358 nmod Rec8Mei8,Rec8Mei8
R7695 T11358 T11355 nmod Rec8Mei8,testis
R7696 T11359 T11358 punct /,Rec8Mei8
R7697 T11360 T11355 nmod Trip13Gt,testis
R7698 T11361 T11360 punct /,Trip13Gt
R7699 T11362 T11360 punct +,Trip13Gt
R7700 T11363 T11355 punct .,testis
R7701 T11365 T11366 det The,allele
R7702 T11366 T11368 nsubjpass allele,described
R7703 T11367 T11366 compound Rec8Mei8,allele
R7704 T11369 T11368 auxpass was,described
R7705 T11370 T11371 punct [,39
R7706 T11371 T11368 parataxis 39,described
R7707 T11372 T11371 punct ],39
R7708 T11373 T11368 punct .,described
R7709 T11375 T11376 det The,specimen
R7710 T11376 T11377 nsubjpass specimen,taken
R7711 T11378 T11377 auxpass was,taken
R7712 T11379 T11377 prep from,taken
R7713 T11380 T11381 det a,littermate
R7714 T11381 T11379 pobj littermate,from
R7715 T11382 T11381 prep of,littermate
R7716 T11383 T11382 pobj that,of
R7717 T11384 T11383 prep in,that
R7718 T11385 T11384 punct (,in
R7719 T11386 T11384 pobj M,in
R7720 T11387 T11384 punct ),in
R7721 T11388 T11377 punct .,taken
R7722 T11390 T11391 punct (,M
R7723 T11391 T11392 meta M,testis
R7724 T11393 T11391 punct ),M
R7725 T11394 T11395 compound Rec8Mei8,Rec8Mei8
R7726 T11395 T11392 compound Rec8Mei8,testis
R7727 T11396 T11395 punct /,Rec8Mei8
R7728 T11397 T11398 compound Trip13Gt,Gt
R7729 T11398 T11392 compound Gt,testis
R7730 T11399 T11398 punct /,Gt
R7731 T11400 T11392 punct .,testis
R7732 T11402 T11403 punct (,N
R7733 T11403 T11404 meta N,testis
R7734 T11405 T11403 punct ),N
R7735 T11406 T11404 nmod Dmc1,testis
R7736 T11407 T11406 punct −,Dmc1
R7737 T11408 T11406 punct /,Dmc1
R7738 T11409 T11406 punct −,Dmc1
R7739 T11410 T11411 compound Trip13Gt,Gt
R7740 T11411 T11404 compound Gt,testis
R7741 T11412 T11411 punct /,Gt
R7742 T11413 T11404 punct .,testis
R7743 T11415 T11416 punct (,O
R7744 T11416 T11417 meta O,ovary
R7745 T11418 T11416 punct ),O
R7746 T11419 T11417 nmod Spo11,ovary
R7747 T11420 T11419 punct −,Spo11
R7748 T11421 T11419 punct /,Spo11
R7749 T11422 T11419 punct −,Spo11
R7750 T11423 T11417 nmod Trip13Gt,ovary
R7751 T11424 T11423 punct /,Trip13Gt
R7752 T11425 T11423 punct +,Trip13Gt
R7753 T11426 T11427 nummod 25,d
R7754 T11427 T11429 npadvmod d,old
R7755 T11428 T11427 punct -,d
R7756 T11429 T11417 amod old,ovary
R7757 T11430 T11429 punct -,old
R7758 T11431 T11417 punct .,ovary
R7759 T11433 T11434 det The,specimen
R7760 T11434 T11435 nsubjpass specimen,taken
R7761 T11436 T11435 auxpass was,taken
R7762 T11437 T11435 prep from,taken
R7763 T11438 T11439 det a,littermate
R7764 T11439 T11437 pobj littermate,from
R7765 T11440 T11439 prep of,littermate
R7766 T11441 T11440 pobj that,of
R7767 T11442 T11441 prep in,that
R7768 T11443 T11444 punct (,P
R7769 T11444 T11442 pobj P,in
R7770 T11445 T11444 punct ),P
R7771 T11446 T11435 punct .,taken
R7772 T11448 T11449 punct (,P
R7773 T11449 T11450 meta P,ovary
R7774 T11451 T11449 punct ),P
R7775 T11452 T11450 nmod Spo11,ovary
R7776 T11453 T11452 punct −,Spo11
R7777 T11454 T11452 punct /,Spo11
R7778 T11455 T11452 punct −,Spo11
R7779 T11456 T11457 nmod Trip13Gt,Gt
R7780 T11457 T11450 nmod Gt,ovary
R7781 T11458 T11457 punct /,Gt
R7782 T11459 T11460 nummod 25,d
R7783 T11460 T11462 npadvmod d,old
R7784 T11461 T11460 punct -,d
R7785 T11462 T11450 amod old,ovary
R7786 T11463 T11462 punct -,old
R7787 T11464 T11450 punct .,ovary
R7788 T11466 T11467 punct (,Q
R7789 T11467 T11468 meta Q,ovary
R7790 T11469 T11467 punct ),Q
R7791 T11470 T11468 nmod Mei1,ovary
R7792 T11471 T11470 punct −,Mei1
R7793 T11472 T11470 punct /,Mei1
R7794 T11473 T11470 punct −,Mei1
R7795 T11474 T11468 nmod Trip13Gt,ovary
R7796 T11475 T11474 punct /,Trip13Gt
R7797 T11476 T11474 punct +,Trip13Gt
R7798 T11477 T11478 nummod 25,d
R7799 T11478 T11480 npadvmod d,old
R7800 T11479 T11478 punct -,d
R7801 T11480 T11468 amod old,ovary
R7802 T11481 T11480 punct -,old
R7803 T11482 T11468 punct .,ovary
R7804 T11484 T11485 det The,specimen
R7805 T11485 T11486 nsubjpass specimen,taken
R7806 T11487 T11486 auxpass was,taken
R7807 T11488 T11486 prep from,taken
R7808 T11489 T11490 det a,littermate
R7809 T11490 T11488 pobj littermate,from
R7810 T11491 T11490 prep of,littermate
R7811 T11492 T11491 pobj that,of
R7812 T11493 T11492 prep in,that
R7813 T11494 T11495 punct (,R
R7814 T11495 T11493 pobj R,in
R7815 T11496 T11495 punct ),R
R7816 T11497 T11486 punct .,taken
R7817 T11499 T11500 punct (,R
R7818 T11500 T11501 meta R,ovary
R7819 T11502 T11500 punct ),R
R7820 T11503 T11501 nmod Mei1,ovary
R7821 T11504 T11503 punct −,Mei1
R7822 T11505 T11503 punct /,Mei1
R7823 T11506 T11503 punct −,Mei1
R7824 T11507 T11508 nmod Trip13Gt,Gt
R7825 T11508 T11501 nmod Gt,ovary
R7826 T11509 T11508 punct /,Gt
R7827 T11510 T11511 nummod 25,d
R7828 T11511 T11513 npadvmod d,old
R7829 T11512 T11511 punct -,d
R7830 T11513 T11501 amod old,ovary
R7831 T11514 T11513 punct -,old
R7832 T11515 T11501 punct .,ovary
R7833 T11517 T11518 punct (,S
R7834 T11518 T11519 meta S,ovary
R7835 T11520 T11518 punct ),S
R7836 T11521 T11522 nmod Rec8Mei8,Rec8Mei8
R7837 T11522 T11519 nmod Rec8Mei8,ovary
R7838 T11523 T11522 punct /,Rec8Mei8
R7839 T11524 T11519 nmod Trip13Gt,ovary
R7840 T11525 T11524 punct /,Trip13Gt
R7841 T11526 T11524 punct +,Trip13Gt
R7842 T11527 T11528 nummod 25,d
R7843 T11528 T11530 npadvmod d,old
R7844 T11529 T11528 punct -,d
R7845 T11530 T11519 amod old,ovary
R7846 T11531 T11530 punct -,old
R7847 T11532 T11519 punct .,ovary
R7848 T11534 T11535 det The,specimen
R7849 T11535 T11536 nsubjpass specimen,taken
R7850 T11537 T11536 auxpass was,taken
R7851 T11538 T11536 prep from,taken
R7852 T11539 T11540 det a,littermate
R7853 T11540 T11538 pobj littermate,from
R7854 T11541 T11540 prep of,littermate
R7855 T11542 T11541 pobj that,of
R7856 T11543 T11542 prep in,that
R7857 T11544 T11545 punct (,T
R7858 T11545 T11543 pobj T,in
R7859 T11546 T11545 punct ),T
R7860 T11547 T11536 punct .,taken
R7861 T11549 T11550 punct (,T
R7862 T11550 T11551 meta T,ovary
R7863 T11552 T11550 punct ),T
R7864 T11553 T11554 nmod Rec8Mei8,Rec8Mei8
R7865 T11554 T11551 nmod Rec8Mei8,ovary
R7866 T11555 T11554 punct /,Rec8Mei8
R7867 T11556 T11557 nmod Trip13Gt,Gt
R7868 T11557 T11551 nmod Gt,ovary
R7869 T11558 T11557 punct /,Gt
R7870 T11559 T11560 nummod 25,d
R7871 T11560 T11562 npadvmod d,old
R7872 T11561 T11560 punct -,d
R7873 T11562 T11551 amod old,ovary
R7874 T11563 T11562 punct -,old
R7875 T11564 T11551 punct .,ovary
R7876 T11701 T11702 amod Immunohistochemical,Analysis
R7877 T11703 T11702 prep of,Analysis
R7878 T11704 T11705 compound Pachytene,Chromosomes
R7879 T11705 T11703 pobj Chromosomes,of
R7880 T11706 T11705 compound Spermatocyte,Chromosomes
R7881 T11708 T11709 compound Surface,spread
R7882 T11709 T11711 compound spread,chromosomes
R7883 T11710 T11709 punct -,spread
R7884 T11711 T11712 nsubjpass chromosomes,immunolabeled
R7885 T11713 T11712 auxpass were,immunolabeled
R7886 T11714 T11712 prep with,immunolabeled
R7887 T11715 T11716 det the,antibodies
R7888 T11716 T11714 pobj antibodies,with
R7889 T11717 T11716 amod indicated,antibodies
R7890 T11718 T11716 cc and,antibodies
R7891 T11719 T11716 conj fluorophores,antibodies
R7892 T11720 T11712 punct .,immunolabeled
R7893 T11722 T11723 mark As,indicated
R7894 T11723 T11724 advcl indicated,were
R7895 T11725 T11723 prep in,indicated
R7896 T11726 T11727 det the,right
R7897 T11727 T11725 pobj right,in
R7898 T11728 T11727 amod upper,right
R7899 T11729 T11727 prep of,right
R7900 T11730 T11731 det each,panel
R7901 T11731 T11729 pobj panel,of
R7902 T11732 T11724 punct ", ",were
R7903 T11733 T11724 nsubj cells,were
R7904 T11734 T11724 prep from,were
R7905 T11735 T11736 amod wild,type
R7906 T11736 T11734 pobj type,from
R7907 T11737 T11736 punct (,type
R7908 T11738 T11736 appos WT,type
R7909 T11739 T11738 punct ", ",WT
R7910 T11740 T11741 preconj either,+
R7911 T11741 T11738 appos +,WT
R7912 T11742 T11741 punct +,+
R7913 T11743 T11741 punct /,+
R7914 T11744 T11741 cc or,+
R7915 T11745 T11741 conj Trip13Gt,+
R7916 T11746 T11745 punct /,Trip13Gt
R7917 T11747 T11745 punct +,Trip13Gt
R7918 T11748 T11736 punct ),type
R7919 T11749 T11736 cc or,type
R7920 T11750 T11751 compound Trip13Gt,Gt
R7921 T11751 T11736 conj Gt,type
R7922 T11752 T11751 punct /,Gt
R7923 T11753 T11751 punct (,Gt
R7924 T11754 T11751 appos Mut,Gt
R7925 T11755 T11724 punct ),were
R7926 T11756 T11724 punct .,were
R7927 T11758 T11759 expl There,were
R7928 T11760 T11761 det no,differences
R7929 T11761 T11759 attr differences,were
R7930 T11762 T11761 acl seen,differences
R7931 T11763 T11762 prep between,seen
R7932 T11764 T11763 pobj heterozygotes,between
R7933 T11765 T11764 cc and,heterozygotes
R7934 T11766 T11767 punct +,+
R7935 T11767 T11769 punct +,spermatocytes
R7936 T11768 T11767 punct /,+
R7937 T11769 T11764 conj spermatocytes,heterozygotes
R7938 T11770 T11759 punct .,were
R7939 T11772 T11773 punct (,A
R7940 T11773 T11774 meta A,nucleus
R7941 T11775 T11773 punct ),A
R7942 T11776 T11774 det A,nucleus
R7943 T11777 T11774 compound mutant,nucleus
R7944 T11778 T11774 compound pachytene,nucleus
R7945 T11779 T11774 prep with,nucleus
R7946 T11780 T11781 amod full,synapsis
R7947 T11781 T11779 pobj synapsis,with
R7948 T11782 T11774 punct .,nucleus
R7949 T11784 T11785 nsubj Areas,are
R7950 T11786 T11784 prep of,Areas
R7951 T11787 T11788 compound SYCP1,SYCP3
R7952 T11788 T11790 compound SYCP3,colabeling
R7953 T11789 T11788 punct /,SYCP3
R7954 T11790 T11786 pobj colabeling,of
R7955 T11791 T11785 acomp yellow,are
R7956 T11792 T11785 punct .,are
R7957 T11794 T11795 punct (,B
R7958 T11795 T11796 meta B,nucleus
R7959 T11797 T11795 punct –,B
R7960 T11798 T11795 dep E,B
R7961 T11799 T11795 punct ),B
R7962 T11800 T11796 compound Spermatocytes,nucleus
R7963 T11801 T11796 prep from,nucleus
R7964 T11802 T11803 nummod 17.5,d
R7965 T11803 T11804 npadvmod d,postpartum
R7966 T11804 T11805 amod postpartum,mutant
R7967 T11805 T11801 pobj mutant,from
R7968 T11806 T11796 punct .,nucleus
R7969 T11808 T11809 amod Asynapsed,chromosomes
R7970 T11809 T11810 nsubjpass chromosomes,indicated
R7971 T11811 T11809 cc or,chromosomes
R7972 T11812 T11809 conj regions,chromosomes
R7973 T11813 T11812 prep of,regions
R7974 T11814 T11813 pobj chromosomes,of
R7975 T11815 T11810 auxpass are,indicated
R7976 T11816 T11810 agent by,indicated
R7977 T11817 T11818 amod white,arrows
R7978 T11818 T11816 pobj arrows,by
R7979 T11819 T11817 cc and,white
R7980 T11820 T11817 conj yellow,white
R7981 T11821 T11810 punct ", ",indicated
R7982 T11822 T11810 advmod respectively,indicated
R7983 T11823 T11810 punct .,indicated
R7984 T11825 T11826 prep Unlike,are
R7985 T11827 T11828 det the,distribution
R7986 T11828 T11825 pobj distribution,Unlike
R7987 T11829 T11828 amod normal,distribution
R7988 T11830 T11828 prep in,distribution
R7989 T11831 T11832 amod wild,type
R7990 T11832 T11834 compound type,spermatocytes
R7991 T11833 T11832 punct -,type
R7992 T11834 T11830 pobj spermatocytes,in
R7993 T11835 T11834 compound pachytene,spermatocytes
R7994 T11836 T11837 punct (,C
R7995 T11837 T11828 parataxis C,distribution
R7996 T11838 T11837 punct ),C
R7997 T11839 T11826 punct ", ",are
R7998 T11840 T11841 compound BLM,foci
R7999 T11841 T11826 nsubj foci,are
R8000 T11842 T11826 acomp present,are
R8001 T11843 T11826 prep on,are
R8002 T11844 T11845 amod synapsed,chromosomes
R8003 T11845 T11843 pobj chromosomes,on
R8004 T11846 T11845 compound pachytene,chromosomes
R8005 T11847 T11845 prep in,chromosomes
R8006 T11848 T11849 det the,mutant
R8007 T11849 T11847 pobj mutant,in
R8008 T11850 T11851 punct (,D
R8009 T11851 T11826 parataxis D,are
R8010 T11852 T11851 punct ),D
R8011 T11853 T11826 punct .,are
R8012 T11855 T11856 compound RAD51,foci
R8013 T11856 T11857 nsubj foci,disappear
R8014 T11858 T11856 punct ", ",foci
R8015 T11859 T11860 dep which,are
R8016 T11860 T11856 relcl are,foci
R8017 T11861 T11860 acomp abundant,are
R8018 T11862 T11863 advmod earlier,in
R8019 T11863 T11860 prep in,are
R8020 T11864 T11863 pobj prophase,in
R8021 T11865 T11857 punct ", ",disappear
R8022 T11866 T11857 prep from,disappear
R8023 T11867 T11866 pobj autosomes,from
R8024 T11868 T11857 prep in,disappear
R8025 T11869 T11870 amod wild,type
R8026 T11870 T11872 compound type,nuclei
R8027 T11871 T11870 punct -,type
R8028 T11872 T11868 pobj nuclei,in
R8029 T11873 T11872 compound pachytene,nuclei
R8030 T11874 T11875 punct (,E
R8031 T11875 T11857 parataxis E,disappear
R8032 T11876 T11875 punct ),E
R8033 T11877 T11857 cc and,disappear
R8034 T11878 T11879 det the,bulk
R8035 T11879 T11880 nsubj bulk,is
R8036 T11880 T11857 conj is,disappear
R8037 T11881 T11879 prep of,bulk
R8038 T11882 T11881 pobj staining,of
R8039 T11883 T11880 prep over,is
R8040 T11884 T11885 det the,body
R8041 T11885 T11883 pobj body,over
R8042 T11886 T11885 compound XY,body
R8043 T11887 T11888 punct (,arrow
R8044 T11888 T11880 parataxis arrow,is
R8045 T11889 T11888 punct ),arrow
R8046 T11890 T11880 punct .,is
R8047 T11892 T11893 punct (,F
R8048 T11893 T11894 meta F,persists
R8049 T11895 T11893 punct ),F
R8050 T11896 T11894 nsubj RAD51,persists
R8051 T11897 T11894 prep on,persists
R8052 T11898 T11899 det the,chromosomes
R8053 T11899 T11897 pobj chromosomes,on
R8054 T11900 T11899 amod synapsed,chromosomes
R8055 T11901 T11899 compound mutant,chromosomes
R8056 T11902 T11903 punct (,arrows
R8057 T11903 T11894 parataxis arrows,persists
R8058 T11904 T11903 punct ),arrows
R8059 T11905 T11894 punct .,persists
R8060 T11907 T11908 punct (,G
R8061 T11908 T11909 meta G,restricted
R8062 T11910 T11908 punct ),G
R8063 T11911 T11912 compound H2AX,phosphorylation
R8064 T11912 T11909 nsubjpass phosphorylation,restricted
R8065 T11913 T11909 auxpass is,restricted
R8066 T11914 T11909 prep to,restricted
R8067 T11915 T11916 det the,body
R8068 T11916 T11914 pobj body,to
R8069 T11917 T11916 compound XY,body
R8070 T11918 T11909 prep in,restricted
R8071 T11919 T11918 pobj WT,in
R8072 T11920 T11909 punct .,restricted
R8073 T11922 T11923 punct (,H
R8074 T11923 T11924 meta H,is
R8075 T11925 T11923 punct ),H
R8076 T11926 T11924 prep In,is
R8077 T11927 T11926 pobj addition,In
R8078 T11928 T11927 prep to,addition
R8079 T11929 T11930 det a,area
R8080 T11930 T11928 pobj area,to
R8081 T11931 T11930 amod large,area
R8082 T11932 T11930 prep of,area
R8083 T11933 T11934 compound γH2AX,staining
R8084 T11934 T11932 pobj staining,of
R8085 T11935 T11936 punct (,arrow
R8086 T11936 T11930 parataxis arrow,area
R8087 T11937 T11936 punct ),arrow
R8088 T11938 T11930 prep over,area
R8089 T11939 T11940 det the,body
R8090 T11940 T11938 pobj body,over
R8091 T11941 T11940 compound XY,body
R8092 T11942 T11924 punct ", ",is
R8093 T11943 T11924 expl there,is
R8094 T11944 T11945 amod extensive,phosphorylation
R8095 T11945 T11924 attr phosphorylation,is
R8096 T11946 T11945 amod autosomal,phosphorylation
R8097 T11947 T11945 compound H2AX,phosphorylation
R8098 T11948 T11949 punct (,arrows
R8099 T11949 T11924 parataxis arrows,is
R8100 T11950 T11949 punct ),arrows
R8101 T11951 T11924 punct .,is
R8102 T11953 T11954 punct (,I
R8103 T11954 T11955 meta I,Note
R8104 T11956 T11954 punct ", ",I
R8105 T11957 T11954 dep J,I
R8106 T11958 T11954 punct ),I
R8107 T11959 T11960 mark that,is
R8108 T11960 T11955 ccomp is,Note
R8109 T11961 T11960 prep in,is
R8110 T11962 T11963 amod wild,type
R8111 T11963 T11965 compound type,spermatocytes
R8112 T11964 T11963 punct -,type
R8113 T11965 T11961 pobj spermatocytes,in
R8114 T11966 T11965 compound pachytene,spermatocytes
R8115 T11967 T11960 punct ", ",is
R8116 T11968 T11960 nsubj TOPBP1,is
R8117 T11969 T11960 acomp present,is
R8118 T11970 T11971 advmod only,over
R8119 T11971 T11960 prep over,is
R8120 T11972 T11973 det the,body
R8121 T11973 T11971 pobj body,over
R8122 T11974 T11973 compound XY,body
R8123 T11975 T11976 punct (,arrow
R8124 T11976 T11960 parataxis arrow,is
R8125 T11977 T11976 amod yellow,arrow
R8126 T11978 T11976 punct ),arrow
R8127 T11979 T11955 punct .,Note
R8128 T11981 T11982 prep In,denotes
R8129 T11983 T11984 det the,mutant
R8130 T11984 T11981 pobj mutant,In
R8131 T11985 T11986 punct (,J
R8132 T11986 T11984 parataxis J,mutant
R8133 T11987 T11986 punct ),J
R8134 T11988 T11982 punct ", ",denotes
R8135 T11989 T11990 det an,arrow
R8136 T11990 T11982 nsubj arrow,denotes
R8137 T11991 T11992 nummod one,area
R8138 T11992 T11982 dobj area,denotes
R8139 T11993 T11992 prep of,area
R8140 T11994 T11995 amod intensive,staining
R8141 T11995 T11993 pobj staining,of
R8142 T11996 T11997 dep that,be
R8143 T11997 T11992 relcl be,area
R8144 T11998 T11997 aux may,be
R8145 T11999 T11997 prep over,be
R8146 T12000 T12001 det the,chromosomes
R8147 T12001 T11999 pobj chromosomes,over
R8148 T12002 T12001 compound sex,chromosomes
R8149 T12003 T11982 punct ", ",denotes
R8150 T12004 T11982 cc but,denotes
R8151 T12005 T12006 amod many,cores
R8152 T12006 T12009 nsubjpass cores,stained
R8153 T12007 T12006 amod other,cores
R8154 T12008 T12006 compound chromosome,cores
R8155 T12009 T11982 conj stained,denotes
R8156 T12010 T12009 auxpass are,stained
R8157 T12011 T12009 advmod positively,stained
R8158 T12012 T12009 punct .,stained
R8159 T12014 T12015 punct (,K
R8160 T12015 T12016 meta K,persists
R8161 T12017 T12015 punct ", ",K
R8162 T12018 T12015 dep L,K
R8163 T12019 T12015 punct ),K
R8164 T12020 T12016 nsubj RPA,persists
R8165 T12021 T12016 prep along,persists
R8166 T12022 T12023 amod synapsed,cores
R8167 T12023 T12021 pobj cores,along
R8168 T12024 T12016 prep in,persists
R8169 T12025 T12026 det the,mutant
R8170 T12026 T12024 pobj mutant,in
R8171 T12027 T12026 punct ", ",mutant
R8172 T12028 T12026 cc not,mutant
R8173 T12029 T12026 conj WT,mutant
R8174 T12030 T12016 punct .,persists
R8175 T12032 T12033 punct (,M
R8176 T12033 T12034 meta M,indicate
R8177 T12035 T12033 punct ", ",M
R8178 T12036 T12033 dep N,M
R8179 T12037 T12033 punct ),M
R8180 T12038 T12034 nsubj Arrows,indicate
R8181 T12039 T12034 dobj examples,indicate
R8182 T12040 T12039 prep of,examples
R8183 T12041 T12042 compound MLH3,foci
R8184 T12042 T12040 pobj foci,of
R8185 T12043 T12042 prep on,foci
R8186 T12044 T12043 pobj SCs,on
R8187 T12045 T12034 punct .,indicate
R8188 T12047 T12048 punct (,O
R8189 T12048 T12049 meta O,is
R8190 T12050 T12048 punct ),O
R8191 T12051 T12049 prep In,is
R8192 T12052 T12053 nmod WT,spermatocytes
R8193 T12053 T12051 pobj spermatocytes,In
R8194 T12054 T12053 amod late,spermatocytes
R8195 T12055 T12053 compound pachytene,spermatocytes
R8196 T12056 T12049 punct ", ",is
R8197 T12057 T12049 nsubj RAD51,is
R8198 T12058 T12049 acomp present,is
R8199 T12059 T12060 advmod only,at
R8200 T12060 T12049 prep at,is
R8201 T12061 T12062 compound background,levels
R8202 T12062 T12060 pobj levels,at
R8203 T12063 T12049 punct .,is
R8204 T12065 T12066 punct (,P
R8205 T12066 T12067 meta P,delineates
R8206 T12068 T12066 punct ),P
R8207 T12069 T12067 prep As,delineates
R8208 T12070 T12069 prep in,As
R8209 T12071 T12072 punct (,F
R8210 T12072 T12070 pobj F,in
R8211 T12073 T12072 punct ),F
R8212 T12074 T12067 punct ", ",delineates
R8213 T12075 T12076 amod extensive,staining
R8214 T12076 T12067 nsubj staining,delineates
R8215 T12077 T12076 compound RAD51,staining
R8216 T12078 T12067 dobj SCs,delineates
R8217 T12079 T12078 prep in,SCs
R8218 T12080 T12081 compound mutant,nuclei
R8219 T12081 T12079 pobj nuclei,in
R8220 T12082 T12081 compound pachytene,nuclei
R8221 T12083 T12078 punct (,SCs
R8222 T12084 T12078 acl indicated,SCs
R8223 T12085 T12084 agent by,indicated
R8224 T12086 T12087 amod white,arcs
R8225 T12087 T12085 pobj arcs,by
R8226 T12088 T12067 punct ),delineates
R8227 T12089 T12067 punct .,delineates
R8228 T12091 T12092 compound MLH1,foci
R8229 T12092 T12093 nsubj foci,colocalize
R8230 T12094 T12093 prep with,colocalize
R8231 T12095 T12096 det these,tracts
R8232 T12096 T12094 pobj tracts,with
R8233 T12097 T12098 punct (,arrows
R8234 T12098 T12096 parataxis arrows,tracts
R8235 T12099 T12098 punct ),arrows
R8236 T12100 T12093 prep at,colocalize
R8237 T12101 T12102 det the,foci
R8238 T12102 T12100 pobj foci,at
R8239 T12103 T12102 amod typical,foci
R8240 T12104 T12105 quantmod 1,2
R8241 T12105 T12102 nummod 2,foci
R8242 T12106 T12105 punct –,2
R8243 T12107 T12102 prep per,foci
R8244 T12108 T12107 pobj chromosome,per
R8245 T12109 T12093 prep as,colocalize
R8246 T12110 T12109 prep in,as
R8247 T12111 T12112 punct (,M
R8248 T12112 T12110 pobj M,in
R8249 T12113 T12112 punct ),M
R8250 T12114 T12093 punct .,colocalize
R8251 T12126 T12127 amod Immunocytological,Analysis
R8252 T12128 T12127 prep of,Analysis
R8253 T12129 T12130 compound Trip13,Mutants
R8254 T12130 T12128 pobj Mutants,of
R8255 T12131 T12130 compound Compound,Mutants
R8256 T12133 T12134 compound Surface,spread
R8257 T12134 T12136 compound spread,chromosomes
R8258 T12135 T12134 punct -,spread
R8259 T12136 T12137 nsubjpass chromosomes,immunolabeled
R8260 T12138 T12137 auxpass were,immunolabeled
R8261 T12139 T12137 prep with,immunolabeled
R8262 T12140 T12141 det the,antibodies
R8263 T12141 T12139 pobj antibodies,with
R8264 T12142 T12141 amod indicated,antibodies
R8265 T12143 T12141 cc and,antibodies
R8266 T12144 T12141 conj fluorophores,antibodies
R8267 T12145 T12137 punct .,immunolabeled
R8268 T12147 T12148 nsubjpass Genotypes,indicated
R8269 T12149 T12148 auxpass are,indicated
R8270 T12150 T12148 punct ", ",indicated
R8271 T12151 T12152 mark as,are
R8272 T12152 T12148 advcl are,indicated
R8273 T12153 T12154 det those,panels
R8274 T12154 T12152 nsubj panels,are
R8275 T12155 T12156 prep in,merged
R8276 T12156 T12154 relcl merged,panels
R8277 T12157 T12155 pobj which,in
R8278 T12158 T12159 amod dual,patterns
R8279 T12159 T12156 nsubjpass patterns,merged
R8280 T12160 T12159 compound staining,patterns
R8281 T12161 T12156 auxpass are,merged
R8282 T12162 T12148 punct .,indicated
R8283 T12165 T12166 mark that,are
R8284 T12166 T12164 ccomp are,Note
R8285 T12167 T12168 punct (,H
R8286 T12168 T12166 nsubj H,are
R8287 T12169 T12168 punct ),H
R8288 T12170 T12168 cc and,H
R8289 T12171 T12172 punct (,I
R8290 T12172 T12168 conj I,H
R8291 T12173 T12172 punct ),I
R8292 T12174 T12166 prep at,are
R8293 T12175 T12176 amod lower,magnification
R8294 T12176 T12174 pobj magnification,at
R8295 T12177 T12178 aux to,show
R8296 T12178 T12166 advcl show,are
R8297 T12179 T12180 amod multiple,nuclei
R8298 T12180 T12178 dobj nuclei,show
R8299 T12181 T12164 punct .,Note
R13 T152 T149 cc but,Completing
R14 T153 T152 neg Not,but
R15 T154 T149 conj Synapsis,Completing
R16 T156 T157 prep In,coupled
R17 T158 T159 amod mammalian,meiosis
R18 T159 T156 pobj meiosis,In
R4 T143 T139 nummod 2,Checkpoint
R5 T144 T139 punct (,Checkpoint
R6 T145 T139 appos Trip13,Checkpoint
R7 T146 T142 punct ),Required
R8 T147 T142 auxpass Is,Required
R9 T148 T142 prep for,Required
R10 T149 T148 pobj Completing,for
R11 T150 T151 amod Meiotic,Recombination
R12 T151 T149 dobj Recombination,Completing
R19 T160 T157 punct ", ",coupled
R20 T161 T162 amod homologous,synapsis
R23 T164 T157 auxpass is,coupled
R24 T165 T157 prep with,coupled
R25 T166 T165 pobj recombination,with
R26 T167 T157 punct .,coupled
R27 T169 T170 prep As,have
R28 T171 T169 prep in,As
R29 T172 T173 amod most,eukaryotes
R30 T173 T171 pobj eukaryotes,in
R31 T174 T170 punct ", ",have
R32 T175 T176 amod mammalian,meiocytes
R33 T176 T170 nsubj meiocytes,have
R34 T177 T170 dobj checkpoints,have
R35 T178 T179 dep that,monitor
R36 T179 T177 relcl monitor,checkpoints
R37 T180 T181 det the,fidelity
R38 T181 T179 dobj fidelity,monitor
R39 T182 T181 prep of,fidelity
R40 T183 T184 det these,processes
R41 T184 T182 pobj processes,of
R42 T185 T170 punct .,have
R43 T187 T188 nsubj We,report
R44 T189 T190 mark that,required
R47 T192 T190 nsubjpass ortholog,required
R61 T206 T192 appos component,ortholog
R65 T210 T208 pobj checkpoint,of
R75 T220 T190 prep for,required
R76 T221 T220 pobj completion,for
R77 T222 T221 prep of,completion
R78 T223 T222 pobj meiosis,of
R79 T224 T223 prep in,meiosis
R80 T225 T226 det both,sexes
R81 T226 T224 pobj sexes,in
R82 T227 T188 punct .,report
R83 T229 T230 npadvmod TRIP13,deficient
R86 T232 T233 nsubj mice,exhibit
R87 T234 T235 compound spermatocyte,death
R88 T235 T233 dobj death,exhibit
R89 T236 T235 prep in,death
R90 T237 T236 pobj pachynema,in
R91 T238 T235 cc and,death
R92 T239 T235 conj loss,death
R93 T240 T239 prep of,loss
R94 T241 T240 pobj oocytes,of
R95 T242 T239 prep around,loss
R96 T243 T242 pobj birth,around
R97 T244 T233 punct .,exhibit
R98 T246 T247 det The,chromosomes
R99 T247 T248 nsubj chromosomes,synapse
R100 T249 T247 prep of,chromosomes
R101 T250 T251 compound mutant,spermatocytes
R102 T251 T249 pobj spermatocytes,of
R103 T252 T248 advmod fully,synapse
R104 T253 T248 punct ", ",synapse
R105 T254 T248 cc yet,synapse
R106 T255 T248 conj retain,synapse
R107 T256 T257 amod several,markers
R108 T257 T255 dobj markers,retain
R109 T258 T257 prep of,markers
R110 T259 T260 compound recombination,intermediates
R111 T260 T258 pobj intermediates,of
R112 T261 T257 punct ", ",markers
R113 T262 T257 prep including,markers
R114 T263 T262 pobj RAD51,including
R115 T264 T263 punct ", ",RAD51
R116 T265 T263 conj BLM,RAD51
R117 T266 T265 punct ", ",BLM
R118 T267 T265 cc and,BLM
R119 T268 T265 conj RPA,BLM
R120 T269 T248 punct .,synapse
R121 T271 T272 det These,chromosomes
R122 T272 T273 nsubj chromosomes,exhibited
R123 T274 T273 advmod also,exhibited
R124 T275 T276 det the,MLH1
R128 T279 T276 cc and,MLH1
R129 T280 T276 conj MLH3,MLH1
R130 T281 T273 punct ", ",exhibited
R131 T282 T273 cc and,exhibited
R132 T283 T284 amod okadaic,treatment
R139 T290 T286 dobj progression,caused
R140 T291 T290 prep to,progression
R141 T292 T291 pobj metaphase,to
R142 T293 T292 nummod I,metaphase
R143 T294 T290 prep with,progression
R144 T295 T296 amod bivalent,chromosomes
R145 T296 T294 pobj chromosomes,with
R146 T297 T286 punct .,caused
R147 T299 T300 amod Double,analysis
R150 T303 T304 mark that,are
R165 T318 T304 advmod all,are
R166 T319 T304 acomp epistatic,are
R167 T320 T319 prep to,epistatic
R168 T321 T320 pobj Trip13,to
R169 T322 T304 punct ", ",are
R170 T323 T304 advcl suggesting,are
R171 T324 T325 mark that,have
R176 T329 T330 amod meiotic,function
R179 T332 T325 prep in,have
R180 T333 T332 pobj mice,in
R181 T334 T302 punct .,demonstrated
R182 T336 T337 poss Our,data
R183 T337 T338 nsubj data,indicate
R184 T339 T340 mark that,required
R188 T343 T340 prep after,required
R189 T344 T345 compound strand,invasion
R190 T345 T343 pobj invasion,after
R191 T346 T340 prep for,required
R192 T347 T346 pcomp completing,for
R193 T348 T349 det a,subset
R194 T349 T347 dobj subset,completing
R195 T350 T349 prep of,subset
R196 T351 T352 compound recombination,events
R197 T352 T350 pobj events,of
R198 T353 T349 punct ", ",subset
R199 T354 T349 cc but,subset
R200 T355 T354 advmod possibly,but
R201 T356 T354 neg not,but
R202 T357 T349 conj those,subset
R203 T358 T357 acl destined,those
R204 T359 T360 aux to,be
R205 T360 T358 xcomp be,destined
R206 T361 T360 attr crossovers,be
R207 T362 T338 punct .,indicate
R208 T364 T365 prep To,is
R209 T366 T367 poss our,knowledge
R210 T367 T364 pobj knowledge,To
R211 T368 T365 punct ", ",is
R212 T369 T365 nsubj this,is
R213 T370 T371 det the,model
R216 T373 T374 aux to,separate
R217 T374 T371 advcl separate,model
R218 T375 T376 compound recombination,defects
R219 T376 T374 dobj defects,separate
R220 T377 T374 prep from,separate
R221 T378 T377 pobj asynapsis,from
R222 T379 T374 prep in,separate
R223 T380 T381 amod mammalian,meiosis
R224 T381 T379 pobj meiosis,in
R225 T382 T365 punct ", ",is
R226 T383 T365 cc and,is
R227 T384 T365 conj provides,is
R228 T385 T386 det the,evidence
R231 T388 T389 mark that,trigger
R234 T391 T389 nsubj damage,trigger
R238 T395 T396 det the,response
R242 T399 T389 prep in,trigger
R243 T400 T399 pobj mice,in
R244 T401 T365 punct .,is
R1558 T2395 T2391 conj follicles,oocytes
R1559 T2396 T2397 punct (,3C
R1560 T2397 T2361 parataxis 3C,occurred
R1561 T2398 T2397 compound Figure,3C
R1562 T2399 T2397 cc and,3C
R1563 T2400 T2397 conj 3D,3C
R1564 T2401 T2397 punct ),3C
R1565 T2402 T2361 punct .,occurred
R1566 T2404 T2405 advmod Thus,failed
R1567 T2406 T2405 punct ", ",failed
R1568 T2407 T2405 nsubj oocytes,failed
R1569 T2408 T2409 aux to,progress
R1570 T2409 T2405 xcomp progress,failed
R1571 T2410 T2409 prep to,progress
R1572 T2411 T2412 det the,phase
R1573 T2412 T2410 pobj phase,to
R1574 T2413 T2412 nmod dictyate,phase
R1575 T2414 T2415 punct (,resting
R1576 T2415 T2413 parataxis resting,dictyate
R1577 T2416 T2415 punct ),resting
R1578 T2417 T2405 punct .,failed
R1579 T2419 T2420 mark Since,observed
R1580 T2420 T2422 advcl observed,indicates
R1581 T2421 T2420 nsubj we,observed
R1582 T2423 T2420 dobj oocytes,observed
R1583 T2424 T2423 prep with,oocytes
R1584 T2425 T2426 compound pachytene,stage
R1611 T2453 T2454 amod Histological,sections
R1612 T2454 T2455 nsubj sections,revealed
R1613 T2456 T2454 prep of,sections
R1614 T2457 T2458 compound mutant,testes
R1615 T2458 T2456 pobj testes,of
R1616 T2459 T2460 det a,lack
R1617 T2460 T2455 dobj lack,revealed
R1140 T1848 T1849 punct (,N4
R1141 T1849 T1847 parataxis N4,semi-congenic
R1142 T1850 T1849 punct ),N4
R1143 T1851 T1846 prep on,were
R1144 T1852 T1853 det the,strain
R1145 T1853 T1851 pobj strain,on
R1146 T1854 T1855 compound C57BL,6J
R1147 T1855 T1853 compound 6J,strain
R1148 T1856 T1855 punct /,6J
R1149 T1857 T1842 advmod often,were
R1150 T1858 T1859 advmod markedly,smaller
R1151 T1859 T1842 acomp smaller,were
R1152 T1860 T1842 cc and,were
R1153 T1861 T1860 punct /,and
R1154 T1862 T1860 cc or,and
R1155 T1863 T1842 conj had,were
R1156 T1864 T1865 amod kinked,tails
R1157 T1865 T1863 dobj tails,had
R1158 T1866 T1864 cc or,kinked
R1159 T1867 T1864 conj shorter,kinked
R1160 T1868 T1869 punct (,2A
R1161 T1869 T1863 parataxis 2A,had
R1162 T1870 T1869 compound Figure,2A
R1163 T1871 T1869 cc and,2A
R1164 T1872 T1869 conj 2B,2A
R1165 T1873 T1869 punct ),2A
R1166 T1874 T1842 punct .,were
R1167 T1877 T1878 compound RT,PCR
R1168 T1878 T1880 compound PCR,analysis
R1169 T1879 T1878 punct -,PCR
R1170 T1880 T1881 nsubj analysis,revealed
R1171 T1882 T1880 prep of,analysis
R1172 T1883 T1884 compound Trip13Gt,expression
R1173 T1884 T1882 pobj expression,of
R1174 T1885 T1886 punct (,1D
R1175 T1886 T1880 parataxis 1D,analysis
R1176 T1887 T1886 compound Figure,1D
R1177 T1888 T1886 punct ),1D
R1178 T1889 T1890 det a,level
R1179 T1890 T1881 dobj level,revealed
R1180 T1891 T1890 amod low,level
R1181 T1892 T1890 prep of,level
R1182 T1893 T1894 advmod normally,spliced
R1183 T1894 T1895 amod spliced,transcripts
R1184 T1895 T1892 pobj transcripts,of
R1185 T1896 T1890 prep in,level
R1186 T1897 T1896 pobj testes,in
R1187 T1898 T1897 prep of,testes
R1188 T1899 T1898 pobj homozygotes,of
R1189 T1900 T1901 dep that,is
R1190 T1901 T1890 relcl is,level
R1191 T1902 T1901 advmod presumably,is
R1192 T1903 T1904 det a,consequence
R1193 T1904 T1901 attr consequence,is
R1194 T1905 T1904 prep of,consequence
R3316 T5179 T5122 parataxis 5B,disrupted
R3318 T5181 T5179 cc and,5B
R3319 T5182 T5179 conj 5C,5B
R3320 T5183 T5179 punct ),5B
R3321 T5184 T5122 punct .,disrupted
R3322 T5186 T5187 amod Identical,studies
R3323 T5187 T5188 nsubjpass studies,performed
R3324 T5189 T5188 auxpass were,performed
R3325 T5190 T5188 prep with,performed
R3326 T5191 T5190 pobj mice,with
R3327 T5192 T5191 amod deficient,mice
R3328 T5193 T5192 prep for,deficient
R3329 T5194 T5193 pobj Mei1,for
R3330 T5195 T5194 punct ", ",Mei1
R3331 T5196 T5197 det a,gene
R3332 T5197 T5194 appos gene,Mei1
R3333 T5198 T5199 npadvmod vertebrate,specific
R3334 T5199 T5197 amod specific,gene
R3335 T5200 T5199 punct -,specific
R3336 T5201 T5202 advmod also,required
R3337 T5202 T5197 acl required,gene
R3338 T5203 T5202 prep for,required
R3339 T5204 T5205 compound DSB,formation
R3340 T5205 T5203 pobj formation,for
R3341 T5206 T5205 cc and,formation
R3342 T5207 T5208 compound chromosome,synapsis
R3343 T5208 T5205 conj synapsis,formation
R3344 T5209 T5210 punct [,37
R3345 T5210 T5188 parataxis 37,performed
R3366 T5241 T5242 amod le,tion
R3367 T5247 T5246 pobj PCH2,f
R3368 T5248 T5249 det the,arrest
R3369 T5249 T5245 dobj arrest,alleviates
R3370 T5250 T5249 compound pachytene,arrest
R3371 T5251 T5249 acl caused,arrest
R3372 T5252 T5251 agent by,caused
R3373 T5253 T5254 amod asynaptic,zip1
R3374 T5254 T5252 pobj zip1,by
R3375 T5255 T5254 compound mutants,zip1
R3376 T5256 T5254 cc and,zip1
R3377 T5257 T5254 conj zip2,zip1
R3378 T5258 T5259 punct [,8
R3379 T5259 T5245 parataxis 8,alleviates
R3380 T5260 T5259 punct ],8
R3381 T5261 T5245 punct .,alleviates
R3382 T5263 T5264 mark Although,be
R3383 T5264 T5268 advcl be,be
R1899 T3136 T3133 conj 2E,2D
R1900 T3137 T3133 punct ),2D
R1901 T3138 T3124 punct ", ",delay
R1902 T3139 T3140 advmod likely,related
R1903 T3140 T3124 acl related,delay
R1904 T3141 T3140 prep to,related
R1905 T3142 T3143 amod systemic,retardation
R1906 T3143 T3141 pobj retardation,to
R1907 T3144 T3143 amod developmental,retardation
R1908 T3145 T3146 punct (,2A
R1909 T3146 T3140 parataxis 2A,related
R1910 T3147 T3146 compound Figure,2A
R1911 T3148 T3146 cc and,2A
R1912 T3149 T3146 conj 2B,2A
R1913 T3150 T3146 punct ),2A
R1963 T3213 T3214 npadvmod d,at
R1964 T3219 T3217 advmod c,t
R1965 T3222 T3221 amod a,u
R1966 T3227 T3226 punct ,f
R1967 T3229 T3228 pobj e,m
R1968 T3232 T3231 pobj ti,o
R1969 T3252 T3253 amod c,hromosomes
R1970 T3255 T3256 det a,variety
R1971 T3256 T3254 pobj variety,with
R1972 T3257 T3256 prep of,variety
R1973 T3258 T3257 pobj markers,of
R1974 T3259 T3260 dep that,are
R1975 T3260 T3258 relcl are,markers
R1976 T3261 T3260 acomp diagnostic,are
R1977 T3262 T3261 prep of,diagnostic
R1978 T3263 T3262 pobj recombination,of
R1979 T3264 T3263 cc and,recombination
R1980 T3265 T3263 conj synapsis,recombination
R1981 T3268 T3269 nsubj Recombination,appeared
R1982 T3270 T3268 prep in,Recombination
R1983 T3271 T3272 compound Trip13Gt,Gt
R1984 T3272 T3274 compound Gt,spermatocytes
R1985 T3273 T3272 punct /,Gt
R1986 T3274 T3270 pobj spermatocytes,in
R1987 T3275 T3276 aux to,initiate
R1988 T3276 T3269 xcomp initiate,appeared
R1989 T3277 T3276 advmod normally,initiate
R1990 T3278 T3279 mark as,judged
R1991 T3279 T3276 advcl judged,initiate
R1992 T3280 T3279 prep by,judged
R1993 T3281 T3282 det the,presence
R1994 T3282 T3280 pobj presence,by
R1995 T3283 T3282 prep of,presence
R1996 T3284 T3283 pobj γH2AX,of
R1997 T3285 T3282 prep in,presence
R1998 T3286 T3285 pobj leptonema,in
R1999 T3287 T3288 punct (,S2A

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4 30-36 PR:000016672 denotes Trip13
T5 65-72 _FRAGMENT denotes Meiotic
T6 95-103 GO:0007129 denotes Synapsis
T7 152-161 NCBITaxon:40674 denotes mammalian
T8 162-169 GO:0007126 denotes meiosis
T9 171-201 GO:0007129 denotes homologous chromosome synapsis
T10 244-254 NCBITaxon:2759 denotes eukaryotes
T11 256-265 NCBITaxon:40674 denotes mammalian
T12 281-292 GO:0000075 denotes checkpoints
T13 298-305 GO:0065007 denotes monitor
T14 358-363 NCBITaxon:10088 denotes mouse
T15 364-372 SO:0000855 denotes ortholog
T16 374-380 PR:000016672 denotes Trip13
T17 385-405 GO:0051598 denotes pachytene checkpoint
T18 385-407 PR:P38126 denotes pachytene checkpoint 2
T19 409-413 PR:P38126 denotes PCH2
T20 446-454 GO:0007129 denotes synapsis
T21 455-465 GO:0000075 denotes checkpoint
T22 469-493 NCBITaxon:4932 denotes Saccharomyces cerevisiae
T23 498-520 NCBITaxon:6239 denotes Caenorhabditis elegans
T24 552-559 GO:0007126 denotes meiosis
T25 575-581 PR:000016672 denotes TRIP13
T26 592-596 NCBITaxon:10088 denotes mice
T27 605-617 CL:0000017 denotes spermatocyte
T28 618-623 GO:0016265 denotes death
T29 627-636 GO:0000239 denotes pachynema
T30 649-656 CL:0000023 denotes oocytes
T31 664-669 GO:0007567 denotes birth
T32 697-710 CL:0000017 denotes spermatocytes
T33 711-718 GO:0007129 denotes synapse
T34 795-800 PR:000013672 denotes RAD51
T35 802-805 PR:000004759 denotes BLM
T36 811-814 GO:0005662 denotes RPA
T37 853-862 GO:0005712 denotes chiasmata
T38 871-875 PR:000010442 denotes MLH1
T39 880-884 PR:000010443 denotes MLH3
T40 890-902 CHEBI:44658 denotes okadaic acid
T41 923-936 CL:0000017 denotes spermatocytes
T42 959-970 GO:0007132 denotes metaphase I
T43 1061-1069 GO:0007129 denotes synapsis
T44 1070-1075 SO:0000704 denotes genes
T45 1076-1081 PR:000015553 denotes Spo11
T46 1083-1087 PR:000031227 denotes Mei1
T47 1089-1093 PR:000013858 denotes Rec8
T48 1099-1103 PR:000006536 denotes Dmc1
T49 1125-1131 PR:000016672 denotes Trip13
T50 1149-1155 PR:000016672 denotes TRIP13
T51 1170-1188 GO:0033313 denotes meiotic checkpoint
T52 1201-1205 NCBITaxon:10088 denotes mice
T53 1230-1236 PR:000016672 denotes TRIP13
T54 1255-1270 GO:0042148 denotes strand invasion
T55 1358-1368 GO:0035825 denotes crossovers
T56 1464-1473 NCBITaxon:40674 denotes mammalian
T57 1474-1481 GO:0007126 denotes meiosis
T58 1522-1530 GO:0006281 denotes repaired
T59 1564-1584 GO:0051598 denotes pachytene checkpoint
T60 1597-1601 NCBITaxon:10088 denotes mice
T402 2977-2995 GO:0007276 denotes genesis of gametes
T403 2988-2995 CL:0000300 denotes gametes
T404 3026-3032 SO:0001026 denotes genome
T405 3067-3072 GO:0007567 denotes birth
T406 3158-3180 GO:0007127 denotes first meiotic division
T407 3216-3223 GO:0007129 denotes synapse
T408 3311-3318 GO:0006281 denotes repairs
T409 3319-3325 GO:0006281 denotes repair
T410 3326-3339 SO:0000985 denotes double strand
T411 3340-3346 MOP:0000780 denotes breaks
T412 3363-3374 SO:0000704 denotes genetically
T413 3386-3395 GO:0000237 denotes leptonema
T414 3413-3421 GO:0007129 denotes synapsis
T415 3425-3432 GO:0007114 denotes budding
T416 3425-3438 NCBITaxon:4892 denotes budding yeast
T417 3443-3450 NCBITaxon:40674 denotes mammals
T418 3625-3640 GO:0006260 denotes DNA replication
T419 3658-3680 GO:0000725 denotes recombinational repair
T420 3719-3725 GO:0006281 denotes repair
T421 3782-3811 GO:0007129 denotes homologous chromosome pairing
T422 3821-3829 GO:0006281 denotes repaired
T423 3841-3847 MOP:0000780 denotes breaks
T424 3884-3897 GO:0035825 denotes crossing over
T425 3935-3947 GO:0065007 denotes surveillance
T426 3958-3969 GO:0000075 denotes checkpoints
T427 3987-3994 GO:0007126 denotes meiotic
T428 4061-4070 NCBITaxon:1 denotes organisms
T429 4082-4095 NCBITaxon:4932 denotes S. cerevisiae
T430 4097-4120 NCBITaxon:7227 denotes Drosophila melanogaster
T431 4122-4132 NCBITaxon:6239 denotes C. elegans
T432 4138-4142 NCBITaxon:10088 denotes mice
T433 4197-4216 GO:0007129 denotes chromosome synapsis
T434 4225-4232 GO:0007126 denotes meiotic
T435 4247-4256 GO:0000239 denotes pachytene
T436 4266-4284 GO:0007128 denotes meiotic prophase I
T437 4303-4310 GO:0007126 denotes meiotic
T438 4342-4362 GO:0051598 denotes pachytene checkpoint
T439 4383-4390 SO:0000704 denotes Genetic
T440 4406-4419 NCBITaxon:4932 denotes S. cerevisiae
T441 4452-4472 GO:0051598 denotes pachytene checkpoint
T442 4517-4524 GO:0007126 denotes meiosis
T443 4585-4605 GO:0042770 denotes DNA damage signaling
T444 4609-4616 GO:0007067 denotes mitotic
T445 4631-4651 NCBITaxon:3702 denotes Arabidopsis thaliana
T446 4678-4698 GO:0051598 denotes pachytene checkpoint
T447 4739-4749 NCBITaxon:7215 denotes Drosophila
T448 4755-4775 GO:0051598 denotes pachytene checkpoint
T449 4788-4795 GO:0065007 denotes monitor
T450 4811-4818 GO:0007126 denotes meiotic
T451 4830-4840 GO:0008152 denotes metabolism
T452 4844-4857 NCBITaxon:4932 denotes S. cerevisiae
T453 4862-4872 NCBITaxon:6239 denotes C. elegans
T454 4878-4888 GO:0006302 denotes DSB repair
T455 4897-4916 GO:0007129 denotes chromosome synapsis
T456 4928-4932 NCBITaxon:10088 denotes mice
T457 4939-4952 CL:0000017 denotes spermatocytes
T458 4957-4964 CL:0000023 denotes oocytes
T459 4998-5008 GO:0006302 denotes DSB repair
T460 5018-5022 PR:000006536 denotes Dmc1
T461 5024-5028 PR:000010669 denotes Msh5
T462 5034-5037 PR:000004427 denotes Atm
T463 5069-5078 GO:0000239 denotes pachynema
T464 5084-5097 CL:0000017 denotes spermatocytes
T465 5125-5135 GO:0006302 denotes DSB repair
T466 5148-5156 GO:0007129 denotes synapsis
T467 5170-5177 CL:0000023 denotes oocytes
T468 5234-5242 GO:0007129 denotes synapsis
T469 5246-5250 NCBITaxon:10088 denotes mice
T470 5279-5284 SO:0000704 denotes genes
T471 5293-5297 PR:000006536 denotes Dmc1
T472 5315-5323 GO:0007129 denotes synapsis
T473 5394-5414 GO:0051598 denotes pachytene checkpoint
T474 5443-5450 GO:0007126 denotes meiotic
T475 5523-5536 CL:0002371 denotes somatic cells
T476 5565-5585 GO:0051598 denotes pachytene checkpoint
T477 5586-5593 GO:0065007 denotes control
T478 5612-5619 NCBITaxon:40674 denotes mammals
T479 5678-5682 PR:P38126 denotes PCH2
T480 5695-5704 GO:0005730 denotes nucleolar
T481 5763-5776 NCBITaxon:4932 denotes S. cerevisiae
T482 5777-5784 SO:0000704 denotes genetic
T483 5817-5826 GO:0000239 denotes pachytene
T484 5838-5846 GO:0007129 denotes synaptic
T485 5847-5851 PR:P31111 denotes zip1
T486 5925-5934 _FRAGMENT denotes pachytene
T487 5965-5975 GO:0051598 denotes checkpoint
T488 5935-5943 GO:0007129 denotes synapsis
T489 5953-5963 GO:0006302 denotes DSB repair
T490 6003-6007 PR:P38126 denotes PCH2
T491 6008-6017 SO:0000855 denotes orthologs
T492 6033-6042 NCBITaxon:1 denotes organisms
T493 6056-6064 GO:0007129 denotes synaptic
T494 6065-6072 GO:0007126 denotes meiosis
T495 6083-6091 GO:0007129 denotes synaptic
T496 6092-6099 GO:0007126 denotes meiosis
T497 6133-6137 PR:P38126 denotes Pch2
T498 6148-6158 GO:0000075 denotes checkpoint
T499 6170-6177 GO:0065007 denotes monitor
T500 6178-6198 GO:0000795 denotes synaptonemal complex
T501 6200-6202 GO:0000795 denotes SC
T502 6226-6232 NCBITaxon:9606 denotes humans
T503 6258-6262 NCBITaxon:10088 denotes mice
T504 6281-6287 PR:000016672 denotes Trip13
T505 6293-6301 SO:0000855 denotes ortholog
T506 6305-6309 PR:P38126 denotes PCH2
T507 6361-6381 GO:0051598 denotes pachytene checkpoint
T508 6428-6438 GO:0000075 denotes checkpoint
T509 6504-6513 GO:0035825 denotes crossover
T510 6520-6529 _FRAGMENT denotes repair of
T511 6538-6542 GO:0006302 denotes DSBs
T512 6530-6537 GO:0007126 denotes meiotic
T1329 6554-6560 PR:000016672 denotes Trip13
T1330 6573-6582 GO:0010467 denotes Expressed
T1331 6583-6592 NCBITaxon:40674 denotes Mammalian
T1332 6593-6601 SO:0000855 denotes Ortholog
T1333 6605-6609 PR:P38126 denotes PCH2
T1334 6654-6663 NCBITaxon:40674 denotes mammalian
T1335 6664-6672 SO:0000855 denotes ortholog
T1336 6676-6680 PR:P38126 denotes PCH2
T1337 6682-6688 PR:000016672 denotes Trip13
T1338 6690-6697 UBERON:0002046 denotes thyroid
T1339 6690-6705 CHEBI:60311 denotes thyroid hormone
T1340 6690-6737 PR:000016672 denotes thyroid hormone receptor interacting protein 13
T1341 6784-6792 SO:0000857 denotes homology
T1342 6836-6845 SO:0000855 denotes orthologs
T1343 6905-6911 PR:000016672 denotes TRIP13
T1344 6933-6942 NCBITaxon:40674 denotes mammalian
T1345 6976-6982 NCBITaxon:3193 denotes plants
T1346 7003-7017 _FRAGMENT denotes evolutionarily
T1347 7031-7038 SO:0000857 denotes related
T1348 7049-7054 NCBITaxon:7147 denotes flies
T1349 7153-7159 PR:000016672 denotes Trip13
T1350 7171-7180 GO:0010467 denotes expressed
T1351 7197-7206 _FRAGMENT denotes embryonic
T1352 7217-7224 UBERON:0005291 denotes tissues
T1353 7211-7216 UBERON:0007023 denotes adult
T1354 7236-7242 UBERON:0000473 denotes testis
T1355 7272-7277 NCBITaxon:10088 denotes mouse
T1356 7282-7287 NCBITaxon:9606 denotes human
T1357 7288-7291 SO:0000345 denotes EST
T1358 7376-7385 GO:0010467 denotes expressed
T1359 7389-7394 NCBITaxon:9606 denotes human
T1360 7399-7404 NCBITaxon:10088 denotes mouse
T1361 7405-7412 CL:0000023 denotes oocytes
T1581 10346-10351 UBERON:0002415 denotes tails
T1582 11192-11198 PR:000016672 denotes Trip13
T1584 11257-11264 GO:0008380 denotes spliced
T1585 11265-11276 SO:0000673 denotes transcripts
T1586 11280-11286 UBERON:0000473 denotes testes
T1587 11362-11366 SO:0000704 denotes gene
T1588 11374-11380 GO:0008380 denotes splice
T1589 11433-11441 GO:0042571 denotes antibody
T1590 11478-11482 SO:0000147 denotes exon
T1591 11542-11548 UBERON:0000473 denotes testes
T1592 11687-11693 UBERON:0000473 denotes testes
T1593 11803-11809 PR:000016672 denotes TRIP13
T1594 11833-11839 PR:000016672 denotes Trip13
T1595 11911-11917 PR:000016672 denotes Trip13
T1596 11924-11930 SO:0001023 denotes allele
T1597 11973-11982 CL:0000586 denotes germ cell
T1598 11998-12004 PR:000016672 denotes TRIP13
T1599 12008-12017 GO:0010467 denotes expressed
T1600 12042-12052 GO:0010467 denotes expression
T1601 12105-12111 UBERON:0000473 denotes testis
T1602 12144-12150 PR:000016672 denotes TRIP13
T1603 12170-12177 NCBITaxon:9031 denotes chicken
T1604 12190-12198 GO:0042571 denotes antibody
T1605 12272-12278 UBERON:0000473 denotes testes
T1606 12291-12304 CL:0000020 denotes spermatogonia
T1607 12309-12318 GO:0000237 denotes leptotene
T1608 12319-12332 CL:0000017 denotes spermatocytes
T1609 12346-12354 GO:0000238 denotes Zygotene
T1610 12355-12364 GO:0000239 denotes pachytene
T1611 12365-12378 CL:0000017 denotes spermatocytes
T1612 12447-12456 GO:0000239 denotes pachytene
T1613 12457-12470 CL:0000017 denotes spermatocytes
T1614 12472-12478 PR:000016672 denotes TRIP13
T1615 12494-12501 GO:0005634 denotes nuclear
T1616 12543-12549 GO:0005634 denotes nuclei
T1617 12560-12580 UBERON:0001343 denotes seminiferous tubules
T1618 12616-12623 GO:0005634 denotes nuclear
T1619 12638-12644 PR:000016672 denotes TRIP13
T1620 12663-12670 GO:0007126 denotes meiotic
T1621 12716-12728 CL:0000017 denotes spermatocyte
T1622 12729-12735 GO:0005634 denotes nuclei
T1623 12769-12776 GO:0005634 denotes nuclear
T1624 12823-12825 GO:0000795 denotes SC
T1625 12847-12860 GO:0000800 denotes axial element
T1626 12869-12874 PR:000015865 denotes SYCP3
T1627 12883-12899 GO:0098762 denotes meiotic substage
T1628 12913-12919 PR:000016672 denotes TRIP13
T1629 12959-12966 GO:0007126 denotes meiotic
T1630 12967-12973 GO:0005634 denotes nuclei
T2633 19531-19532 GO:0007129 denotes e
T2634 19540-19542 CL:0000017 denotes se
T2635 19547-19548 GO:0030849 denotes e
T2636 19567-19568 GO:0000239 denotes a
T2637 19574-19581 GO:0007126 denotes meiotic
T2638 19582-19583 GO:0007126 denotes c
T2639 19661-19669 GO:0007129 denotes synapsis
T2640 19688-19694 PR:000016672 denotes Trip13
T2641 19700-19713 CL:0000017 denotes spermatocytes
T2642 19782-19791 GO:0000237 denotes leptonema
T2643 19845-19856 GO:0007126 denotes meiotically
T2644 19876-19881 PR:000013672 denotes RAD51
T2645 19889-19893 PR:000006536 denotes DMC1
T2646 19909-19936 GO:0005714 denotes early recombination nodules
T2647 19938-19942 GO:0005714 denotes ERNs
T2648 19982-19988 PR:000016672 denotes Trip13
T2649 19994-20002 GO:0000238 denotes zygotene
T2650 20003-20016 CL:0000017 denotes spermatocytes
T2651 20045-20050 PR:000013672 denotes RAD51
T2652 20051-20059 GO:0042571 denotes antibody
T2653 20078-20082 PR:000006536 denotes DMC1
T2654 20101-20123 GO:0000725 denotes recombinational repair
T2655 20117-20131 GO:0006302 denotes repair of DSBs
T2656 20150-20165 GO:0008278 denotes cohesin complex
T2657 20223-20231 GO:0007129 denotes synaptic
T2658 20312-20319 GO:0007126 denotes meiosis
T2659 20338-20343 PR:000015706 denotes STAG3
T2660 20369-20373 PR:000013858 denotes REC8
T2661 20408-20412 PR:P38126 denotes PCH2
T2662 20527-20531 PR:000016236 denotes TRF2
T2663 20550-20565 GO:0043234 denotes protein complex
T2664 20668-20676 GO:0007129 denotes synapsed
T2665 20696-20704 GO:0007129 denotes synaptic
T2666 20757-20767 GO:0006302 denotes DSB repair
T2667 20787-20796 GO:0000239 denotes pachynema
T2668 20820-20832 CL:0000017 denotes spermatocyte
T2669 20833-20839 GO:0005634 denotes nuclei
T2670 20845-20855 GO:0042571 denotes antibodies
T2671 20864-20873 CHEBI:36357 denotes molecules
T2672 20930-20936 PR:000016672 denotes Trip13
T2673 20962-20965 PR:000004759 denotes BLM
T2674 20995-21000 PR:000013672 denotes RAD51
T2675 21001-21005 PR:000006536 denotes DMC1
T2676 21056-21062 PR:000016548 denotes TOPBP1
T2677 21110-21118 GO:0007129 denotes synapsed
T2678 21136-21141 PR:000013672 denotes RAD51
T2679 21142-21146 PR:000006536 denotes DMC1
T2680 21155-21164 GO:0000239 denotes pachytene
T2681 21165-21178 CL:0000017 denotes spermatocytes
T2682 21267-21274 GO:0001741 denotes XY body
T2683 21299-21307 GO:0000238 denotes zygonema
T2684 21350-21356 PR:000016548 denotes TOPBP1
T2685 21362-21383 GO:0000077 denotes DNA damage–checkpoint
T2686 21404-21407 PR:000004427 denotes ATM
T2687 21440-21443 PR:000004499 denotes ATR
T2688 21490-21498 GO:0007129 denotes synapsed
T2689 21510-21517 GO:0007126 denotes meiotic
T2690 21539-21542 PR:000004759 denotes BLM
T2691 21589-21592 GO:0005662 denotes RPA
T2692 21597-21601 PR:000010668 denotes MSH4
T2693 21673-21683 GO:0035825 denotes crossovers
T2694 21685-21687 GO:0035825 denotes CO
T2695 21737-21740 GO:0005662 denotes RPA
T2696 21813-21822 GO:0007129 denotes synapsing
T2697 21823-21830 GO:0007126 denotes meiotic
T2698 21870-21879 GO:0000239 denotes pachynema
T2699 21908-21915 SO:0000297 denotes D-loops
T2700 21953-21956 GO:0005662 denotes RPA
T2701 21975-21984 GO:0000239 denotes pachytene
T2702 22051-22059 GO:0006281 denotes repaired
T2703 22119-22128 GO:0000239 denotes pachynema
T2704 22144-22165 GO:0000077 denotes DNA damage checkpoint
T2705 22222-22229 GO:0007126 denotes meiotic
T2706 22230-22244 GO:0000803 denotes sex chromosome
T2707 22269-22276 GO:0007126 denotes meiotic
T2708 22277-22289 _FRAGMENT denotes silencing of
T2709 22299-22308 GO:0006342 denotes chromatin
T2710 22292-22298 GO:0007129 denotes paired
T2711 22299-22308 GO:0000785 denotes chromatin
T2712 22339-22349 GO:0042571 denotes antibodies
T2713 22362-22372 GO:0006302 denotes DSB repair
T2714 22384-22393 CHEBI:36357 denotes molecules
T2715 22412-22416 PR:000008418 denotes H2AX
T2716 22470-22473 PR:000004499 denotes ATR
T2717 22479-22482 PR:000004427 denotes ATM
T2718 22527-22535 GO:0007129 denotes synapsed
T2719 22585-22593 GO:0007129 denotes synapsis
T2720 22613-22619 PR:000016672 denotes Trip13
T2721 22642-22652 GO:0006281 denotes DNA repair
T2722 22700-22710 GO:0006281 denotes DNA repair
T2723 22723-22748 GO:0006342 denotes transcriptional silencing
T2724 22793-22799 PR:000016672 denotes Trip13
T2725 22805-22814 GO:0000239 denotes pachytene
T2726 22815-22828 CL:0000017 denotes spermatocytes
T2727 22850-22860 GO:0006281 denotes DNA repair
T2728 22874-22880 UBERON:0000473 denotes testis
T2729 22918-22925 GO:0007126 denotes meiotic
T2730 22968-22977 GO:0000240 denotes diplotene
T2731 22978-22984 GO:0005634 denotes nuclei
T2732 22997-23006 GO:0030849 denotes autosomal
T2733 23007-23012 PR:000013672 denotes RAD51
T2734 23013-23017 PR:000006536 denotes DMC1
T2735 23055-23066 GO:0007132 denotes metaphase I
T2736 23117-23123 PR:000016672 denotes Trip13
T2737 23160-23169 GO:0000240 denotes diplotene
T2738 23174-23185 GO:0007132 denotes metaphase I
T2739 23186-23199 CL:0000017 denotes spermatocytes
T2740 23253-23259 PR:000016672 denotes TRIP13
T3971 23262-23264 GO:0035825 denotes CO
T3972 23318-23324 PR:000016672 denotes TRIP13
T3973 23344-23347 PR:000004759 denotes BLM
T3974 23351-23357 PR:000016672 denotes Trip13
T3975 23363-23375 CL:0000017 denotes spermatocyte
T3976 23429-23437 GO:0006281 denotes repaired
T3977 23480-23502 GO:0000725 denotes recombinational repair
T3978 23522-23538 GO:0035825 denotes CO recombination
T3979 23597-23612 GO:0006298 denotes mismatch repair
T3980 23622-23626 PR:000010442 denotes MLH1
T3981 23631-23635 PR:000010443 denotes MLH3
T3982 23687-23696 GO:0000239 denotes pachynema
T3983 23723-23732 GO:0005712 denotes chiasmata
T3984 23754-23758 PR:000010442 denotes MLH1
T3985 23858-23862 PR:000010443 denotes MLH3
T3986 23902-23911 GO:0000239 denotes pachytene
T3987 23943-23947 PR:000010442 denotes MLH1
T3988 23973-23979 PR:000016672 denotes Trip13
T3989 23985-23994 GO:0000239 denotes pachytene
T3990 23995-24001 GO:0005634 denotes nuclei
T3991 24013-24019 GO:0006281 denotes repair
T3992 24056-24066 GO:0006302 denotes DSB repair
T3993 24104-24113 GO:0000239 denotes pachytene
T3994 24114-24120 GO:0005634 denotes nuclei
T3995 24125-24129 PR:000010442 denotes MLH1
T3996 24163-24167 PR:000010442 denotes MLH1
T3997 24213-24221 GO:0006281 denotes repaired
T3998 24284-24288 PR:000010442 denotes MLH1
T3999 24293-24298 PR:000013672 denotes RAD51
T4000 24299-24303 PR:000006536 denotes DMC1
T4001 24305-24309 PR:000010442 denotes MLH1
T4002 24372-24377 PR:000013672 denotes RAD51
T4003 24378-24382 PR:000006536 denotes DMC1
T4004 24432-24436 PR:000010442 denotes MLH1
T4005 24447-24453 PR:000016672 denotes Trip13
T4006 24459-24468 GO:0000239 denotes pachytene
T4007 24469-24482 CL:0000017 denotes spermatocytes
T4008 24493-24495 GO:0035825 denotes CO
T4009 24593-24603 GO:0007128 denotes prophase I
T4010 24616-24626 UBERON:0000473 denotes testicular
T4011 24669-24675 PR:000016672 denotes Trip13
T4012 24686-24690 PR:000006536 denotes Dmc1
T4013 24695-24699 NCBITaxon:10088 denotes mice
T4014 24729-24738 CHEBI:35222 denotes inhibitor
T4015 24739-24751 CHEBI:44658 denotes okadaic acid
T4016 24753-24755 CHEBI:44658 denotes OA
T4017 24782-24796 _FRAGMENT denotes degradation of
T4018 24801-24803 GO:0070194 denotes SC
T4019 24801-24803 GO:0000795 denotes SC
T4020 24805-24828 GO:0030261 denotes chromosome condensation
T4021 24859-24870 GO:0007132 denotes metaphase I
T4022 24885-24894 GO:0051323 denotes metaphase
T4023 24957-24961 PR:000006536 denotes Dmc1
T4024 24990-25011 GO:0000793 denotes condensed chromosomes
T4025 25032-25038 PR:000016672 denotes Trip13
T4026 25083-25087 PR:000010442 denotes MLH1
T4027 25098-25104 PR:000016672 denotes Trip13
T4028 25110-25119 GO:0000239 denotes pachytene
T4029 25120-25133 CL:0000017 denotes spermatocytes
T4030 25183-25186 GO:0035825 denotes COs
T4031 25234-25240 UBERON:0000473 denotes testes
T4032 25287-25297 GO:0051323 denotes metaphases
T4033 25303-25307 PR:000006536 denotes Dmc1
T4034 25312-25316 NCBITaxon:10088 denotes mice
T4035 25327-25340 CL:0000020 denotes spermatogonia
T4036 25346-25359 CL:0000017 denotes spermatocytes
T4578 25362-25368 PR:000016672 denotes TRIP13
T4579 25399-25406 GO:0007126 denotes Meiotic
T4580 25449-25457 GO:0007129 denotes Synapsis
T4581 25474-25480 PR:000016672 denotes TRIP13
T4582 25501-25510 GO:0006915 denotes apoptosis
T4583 25525-25533 GO:0007129 denotes synapsis
T4584 25540-25550 NCBITaxon:6239 denotes C. elegans
T4585 25564-25568 NCBITaxon:10088 denotes mice
T4586 25597-25602 PR:000015553 denotes Spo11
T4587 25607-25613 PR:000016672 denotes Trip13
T4588 25615-25620 PR:000015553 denotes SPO11
T4589 25678-25689 SO:0000704 denotes genetically
T4590 25712-25721 GO:0000237 denotes leptonema
T4591 25730-25739 NCBITaxon:1 denotes organisms
T4592 25751-25755 NCBITaxon:10088 denotes mice
T4593 25765-25775 NCBITaxon:6239 denotes C. elegans
T4594 25777-25783 PR:Q22236 denotes spo-11
T4595 25791-25798 CL:0000300 denotes gametes
T4596 25815-25823 GO:0007129 denotes synapsis
T4597 25840-25845 PR:P38126 denotes PCH-2
T4598 25856-25865 GO:0006915 denotes apoptosis
T4599 25869-25878 GO:0000239 denotes pachynema
T4600 25887-25891 NCBITaxon:10088 denotes mice
T4601 25893-25898 PR:000015553 denotes Spo11
T4602 25903-25916 CL:0000017 denotes spermatocytes
T4603 25943-25973 GO:0007129 denotes homologous chromosome synapsis
T4604 26044-26052 GO:0000238 denotes zygotene
T4605 26053-26062 GO:0000239 denotes pachytene
T4606 26087-26100 CL:0000017 denotes Spermatocytes
T4607 26104-26110 PR:000016672 denotes Trip13
T4608 26116-26121 PR:000015553 denotes Spo11
T4609 26126-26132 UBERON:0000473 denotes testes
T4610 26186-26191 GO:0016265 denotes death
T4611 26219-26226 GO:0005819 denotes spindle
T4612 26219-26237 GO:0031577 denotes spindle checkpoint
T4613 26255-26264 GO:0005712 denotes chiasmate
T4614 26265-26278 CL:0000017 denotes spermatocytes
T4615 26310-26321 GO:0007132 denotes metaphase I
T4616 26322-26335 CL:0000017 denotes spermatocytes
T4617 26343-26350 GO:0007126 denotes meiotic
T4618 26351-26361 CL:0000018 denotes spermatids
T4619 26371-26377 UBERON:0000473 denotes testes
T4620 26400-26406 PR:000016672 denotes Trip13
T4621 26463-26471 GO:0007129 denotes synapsis
T4622 26475-26481 PR:000016672 denotes Trip13
T4623 26487-26496 GO:0000239 denotes pachytene
T4624 26497-26510 CL:0000017 denotes spermatocytes
T4625 26533-26538 PR:000015553 denotes SPO11
T4626 26555-26564 GO:0000237 denotes leptonema
T4627 26656-26675 GO:0007129 denotes chromosome synapsis
T4628 26693-26706 CL:0000017 denotes spermatocytes
T4629 26734-26739 PR:000015553 denotes Spo11
T4630 26813-26817 NCBITaxon:10088 denotes mice
T4631 26832-26836 PR:000031227 denotes Mei1
T4632 26840-26850 NCBITaxon:7742 denotes vertebrate
T4633 26860-26864 SO:0000704 denotes gene
T4634 26901-26920 GO:0007129 denotes chromosome synapsis
T4635 27337-27341 PR:P38126 denotes PCH2
T4636 27357-27366 GO:0000239 denotes pachytene
T4637 27385-27393 GO:0007129 denotes synaptic
T4638 27402-27406 PR:P31111 denotes zip1
T4639 27411-27415 PR:P53061 denotes zip2
T4640 27430-27435 NCBITaxon:10088 denotes mouse
T4641 27436-27441 PR:000015862 denotes SYCP1
T4642 27493-27498 PR:000015862 denotes Sycp1
T4643 27506-27519 CL:0000017 denotes spermatocytes
T4644 27562-27568 PR:000016672 denotes Trip13
T4645 27629-27634 PR:000015862 denotes Sycp1
T4646 27703-27707 PR:P31111 denotes zip1
T4647 27773-27792 GO:0007129 denotes chromosome synapsis
T4648 27873-27881 GO:0007129 denotes synapsis
T4649 27882-27896 MOP:0000629 denotes polymerization
T4650 27974-27978 PR:000013858 denotes Rec8
T4651 27979-27985 SO:0001023 denotes allele
T4652 27987-27991 PR:000013858 denotes Rec8
T4653 28012-28016 PR:000013858 denotes Rec8
T4654 28021-28028 GO:0007126 denotes Meiotic
T4655 28044-28048 PR:000013858 denotes Rec8
T4656 28056-28069 CL:0000017 denotes spermatocytes
T4657 28107-28128 GO:0007129 denotes interhomolog synaptic
T4658 28162-28172 GO:0006302 denotes DSB repair
T4659 28194-28215 GO:0007129 denotes interhomolog synapsis
T4660 28261-28268 GO:0007129 denotes synapse
T4661 28286-28291 PR:000015862 denotes SYCP1
T4662 28310-28314 PR:000013858 denotes Rec8
T4663 28342-28351 GO:0000240 denotes diplonema
T4664 28355-28366 GO:0007132 denotes metaphase I
T4665 28406-28410 PR:000013858 denotes Rec8
T4666 28427-28433 PR:000016672 denotes Trip13
T4667 28445-28450 PR:000015553 denotes Spo11
T4668 28455-28459 PR:000031227 denotes Mei1
T4669 28486-28492 UBERON:0000473 denotes testes
T4670 28512-28516 PR:000013858 denotes REC8
T4671 28521-28527 PR:000016672 denotes TRIP13
T4672 28542-28546 PR:000013858 denotes Rec8
T4673 28590-28601 GO:0007132 denotes metaphase I
T4674 28617-28623 PR:000016672 denotes Trip13
T4675 28629-28633 NCBITaxon:10088 denotes mice
T4676 28723-28753 GO:0007129 denotes homologous chromosome synapsis
T4677 28766-28770 PR:000013858 denotes Rec8
T4678 28779-28783 PR:000013858 denotes Rec8
T4679 28788-28794 PR:000016672 denotes Trip13
T4680 28800-28813 CL:0000017 denotes spermatocytes
T4681 28842-28846 PR:000013858 denotes Rec8
T4682 28951-28955 PR:P38126 denotes PCH2
T4683 29002-29009 GO:0007126 denotes meiotic
T4684 29046-29053 GO:0007126 denotes meiosis
T4685 29063-29067 PR:000023696 denotes RecA
T4686 29068-29075 SO:0000853 denotes homolog
T4687 29076-29080 PR:000006536 denotes DMC1
T4688 29122-29126 NCBITaxon:10088 denotes mice
T4689 29143-29150 NCBITaxon:33208 denotes animals
T4690 29169-29175 PR:000016672 denotes Trip13
T4691 29180-29184 PR:000006536 denotes Dmc1
T4692 29192-29196 PR:000006536 denotes Dmc1
T4693 29201-29205 NCBITaxon:10088 denotes mice
T4694 29216-29229 CL:0000017 denotes spermatocytes
T4695 29238-29245 GO:0007126 denotes meiotic
T4696 29268-29278 GO:0006302 denotes DSB repair
T4697 29290-29309 GO:0007129 denotes chromosome synapsis
T4698 29316-29331 GO:0007283 denotes spermatogenesis
T4699 29335-29339 PR:000006536 denotes Dmc1
T4700 29344-29350 PR:000016672 denotes Trip13
T4701 29356-29362 UBERON:0000473 denotes testes
T4702 29405-29418 CL:0000017 denotes spermatocytes
T4703 29429-29438 GO:0000785 denotes chromatin
T4704 29457-29465 GO:0000238 denotes zygonema
T4705 29466-29475 GO:0000239 denotes pachynema
T4706 29536-29540 PR:000006536 denotes Dmc1
T4707 29549-29553 PR:000006536 denotes Dmc1
T4708 29558-29564 PR:000016672 denotes Trip13
T4709 29597-29605 GO:0007129 denotes synapsis
T4710 29618-29624 PR:000016672 denotes Trip13
T4711 29681-29686 PR:000013672 denotes RAD51
T4712 29687-29691 PR:000006536 denotes DMC1
T4713 29716-29720 PR:000008418 denotes H2AX
T4714 29760-29764 PR:000006536 denotes Dmc1
T4715 29781-29787 PR:000016672 denotes Trip13
T4716 29824-29831 UBERON:0000992 denotes ovaries
T4717 29846-29850 PR:000006536 denotes Dmc1
T4718 29859-29865 PR:000016672 denotes Trip13
T5742 29907-29914 GO:0007126 denotes Meiotic
T5743 29926-29932 PR:000016672 denotes Trip13
T5744 29938-29945 CL:0000023 denotes Oocytes
T5745 30048-30054 PR:000016672 denotes Trip13
T5746 30069-30073 PR:000031227 denotes Mei1
T5747 30078-30084 PR:000016672 denotes Trip13
T5748 30094-30099 PR:000015553 denotes Spo11
T5749 30104-30110 PR:000016672 denotes Trip13
T5750 30128-30135 UBERON:0000992 denotes ovaries
T5751 30174-30178 PR:000031227 denotes Mei1
T5752 30183-30188 PR:000015553 denotes Spo11
T5753 30226-30231 PR:000015553 denotes Spo11
T5754 30236-30240 PR:000031227 denotes Mei1
T5755 30258-30264 PR:000016672 denotes Trip13
T5756 30268-30277 GO:0048477 denotes oogenesis
T5757 30299-30303 PR:000006536 denotes Dmc1
T5758 30336-30342 CL:0000023 denotes oocyte
T5759 30351-30357 PR:000016672 denotes Trip13
T5760 30492-30499 GO:0007126 denotes meiotic
T5761 30510-30516 PR:000016672 denotes Trip13
T5762 30524-30528 NCBITaxon:10088 denotes mice
T5763 30550-30560 GO:0006302 denotes DSB repair
T5764 30575-30582 UBERON:0000992 denotes ovaries
T5765 30586-30590 PR:000013858 denotes Rec8
T5766 30591-30597 PR:000016672 denotes Trip13
T5767 30628-30635 CL:0000023 denotes oocytes
T5977 30713-30720 SO:0000704 denotes Genetic
T5978 30736-30749 NCBITaxon:4932 denotes S. cerevisiae
T5979 30777-30797 GO:0051598 denotes pachytene checkpoint
T5980 30798-30806 GO:0065007 denotes monitors
T5981 30823-30838 _FRAGMENT denotes recombinational
T5982 30843-30849 GO:0000725 denotes repair
T5983 30839-30849 GO:0006302 denotes DSB repair
T5984 30854-30862 GO:0007129 denotes synapsis
T5985 30912-30929 GO:0000077 denotes repair checkpoint
T5986 30933-30938 PR:000013665 denotes RAD17
T5987 30939-30943 PR:P46946 denotes SAE2
T5988 30965-30973 GO:0007129 denotes synapsis
T5989 30974-30984 GO:0000075 denotes checkpoint
T5990 30988-30992 PR:P38126 denotes PCH2
T5991 30993-30997 PR:P31111 denotes ZIP1
T5992 31028-31033 SO:0000704 denotes genes
T5993 31035-31039 PR:P46946 denotes SAE2
T5994 31044-31048 PR:P31111 denotes ZIP1
T5995 31067-31076 NCBITaxon:40674 denotes mammalian
T5996 31077-31086 SO:0000855 denotes orthologs
T5997 31097-31102 PR:000015862 denotes SYCP1
T5998 31123-31131 SO:0000855 denotes ortholog
T5999 31135-31139 PR:P31111 denotes ZIP1
T6000 31162-31167 NCBITaxon:10088 denotes mouse
T6001 31168-31173 PR:000013665 denotes RAD17
T6002 31174-31182 SO:0000855 denotes ortholog
T6003 31184-31188 PR:P06777 denotes Rad1
T6004 31208-31217 UBERON:0000922 denotes embryonic
T6005 31263-31268 NCBITaxon:10088 denotes mouse
T6006 31269-31273 PR:P38126 denotes Pch2
T6007 31275-31281 PR:000016672 denotes Trip13
T6008 31315-31323 GO:0007129 denotes synapsis
T6009 31324-31334 GO:0000075 denotes checkpoint
T6010 31338-31348 NCBITaxon:6239 denotes C. elegans
T6011 31433-31442 NCBITaxon:40674 denotes mammalian
T6012 31443-31461 GO:0033313 denotes meiotic checkpoint
T6013 31462-31469 GO:0065007 denotes control
T6014 31503-31507 NCBITaxon:10088 denotes mice
T6015 31521-31528 GO:0007126 denotes meiotic
T6016 31541-31547 PR:000016672 denotes TRIP13
T6017 31620-31640 GO:0051598 denotes pachytene checkpoint
T6018 31641-31648 GO:0065007 denotes control
T6019 31726-31729 GO:0035825 denotes COs
T6020 31754-31760 PR:000016672 denotes Trip13
T6021 31794-31800 GO:0006302 denotes repair
T6022 31919-31926 GO:0007126 denotes meiotic
T6023 31954-31967 NCBITaxon:4932 denotes S. cerevisiae
T6024 31969-31971 GO:0035825 denotes CO
T6025 32108-32112 NCBITaxon:10088 denotes Mice
T6026 32145-32147 _FRAGMENT denotes CO
T6027 32159-32172 GO:0007131 denotes recombination
T6028 32214-32219 PR:000015553 denotes SPO11
T6029 32228-32234 MOP:0000780 denotes breaks
T6030 32249-32251 GO:0035825 denotes CO
T6031 32269-32273 PR:000010442 denotes MLH1
T6032 32333-32342 GO:0000239 denotes pachynema
T6033 32473-32483 GO:0006302 denotes DSB repair
T6034 32501-32508 GO:0007126 denotes meiotic
T6035 32528-32533 PR:000013680 denotes RAD54
T6036 32617-32624 GO:0007126 denotes meiosis
T6037 32644-32648 NCBITaxon:10088 denotes mice
T6038 32673-32678 PR:000013680 denotes RAD54
T6039 32689-32702 CL:0000017 denotes spermatocytes
T6040 32735-32740 PR:000013672 denotes RAD51
T6041 32749-32758 GO:0000239 denotes pachytene
T6042 32792-32798 PR:000016672 denotes TRIP13
T6043 32799-32803 NCBITaxon:10088 denotes mice
T6044 32845-32852 GO:0007126 denotes meiotic
T6045 32894-32901 GO:0007114 denotes budding
T6046 32894-32907 NCBITaxon:4892 denotes budding yeast
T6047 32973-32977 PR:P38126 denotes PCH2
T6048 32985-32992 GO:0007126 denotes meiotic
T6049 33058-33073 GO:0075317 denotes ascus formation
T6050 33284-33293 GO:0007127 denotes meiosis I
T6051 33317-33322 PR:000013665 denotes RAD17
T6052 33323-33327 PR:P46946 denotes SAE2
T6053 33328-33338 GO:0000075 denotes checkpoint
T6054 33344-33352 GO:0065007 denotes monitors
T6055 33414-33420 PR:000016672 denotes TRIP13
T6056 33425-33429 PR:P38126 denotes Pch2
T6057 33468-33476 GO:0007129 denotes synapsis
T6058 33487-33493 PR:000016672 denotes TRIP13
T6059 33504-33517 CL:0000017 denotes spermatocytes
T6060 33565-33570 PR:000015553 denotes SPO11
T6061 33575-33579 PR:000031227 denotes MEI1
T6062 33598-33604 PR:000016672 denotes TRIP13
T6063 33706-33708 GO:0035825 denotes CO
T6064 33709-33715 GO:0006281 denotes repair
T6065 33767-33769 CHEBI:44658 denotes OA
T6066 33833-33839 PR:000016672 denotes TRIP13
T6067 33993-33999 PR:000016672 denotes TRIP13
T6068 34016-34030 _FRAGMENT denotes disassembly of
T6069 34058-34067 GO:0032984 denotes complexes
T6070 34035-34057 GO:0000725 denotes recombinational repair
T6071 34058-34067 GO:0032991 denotes complexes
T6072 34126-34132 PR:000016672 denotes Trip13
T6073 34138-34147 GO:0000239 denotes pachytene
T6074 34170-34176 PR:000016672 denotes TRIP13
T6075 34201-34208 SO:0000417 denotes domains
T6076 34236-34240 PR:000022296 denotes ClpA
T6077 34267-34274 _FRAGMENT denotes protein
T6078 34290-34309 GO:0043241 denotes complex disassembly
T6079 34278-34297 GO:0032993 denotes protein/DNA complex
T6080 34278-34309 GO:0032986 denotes protein/DNA complex disassembly
T6081 34376-34383 GO:0007126 denotes meiosis
T6082 34391-34397 PR:000016672 denotes Trip13
T6083 34435-34442 NCBITaxon:33208 denotes animals
T6084 34485-34491 PR:000016672 denotes TRIP13
T6085 34618-34625 GO:0007126 denotes meiosis
T6086 34650-34660 GO:0008219 denotes cell death
T6087 34664-34670 PR:000016672 denotes Trip13
T6088 34734-34744 GO:0006302 denotes DSB repair
T6089 34758-34766 GO:0007129 denotes synapsis
T6090 34817-34823 CL:0000023 denotes oocyte
T6091 34876-34884 GO:0007129 denotes synapsis
T6092 34898-34911 CL:0000017 denotes spermatocytes
T6093 34915-34920 UBERON:0007023 denotes adult
T6094 34921-34927 UBERON:0000473 denotes testes
T6095 35014-35022 GO:0007129 denotes synapsis
T6096 35036-35040 PR:000006536 denotes Dmc1
T6097 35063-35069 PR:000016672 denotes Trip13
T6098 35112-35120 GO:0006281 denotes repaired
T6099 35154-35163 NCBITaxon:40674 denotes mammalian
T6100 35164-35184 GO:0051598 denotes pachytene checkpoint
T6101 35246-35253 CL:0000023 denotes oocytes
T6102 35258-35271 CL:0000017 denotes spermatocytes
T6103 35307-35317 _FRAGMENT denotes DNA damage
T6104 35328-35338 GO:0000077 denotes checkpoint
T6105 35318-35338 GO:0051598 denotes pachytene checkpoint
T6106 35364-35372 GO:0007129 denotes synapsis
T6107 35373-35383 GO:0000075 denotes checkpoint
T6108 35414-35416 CHEBI:44658 denotes OA
T6109 35430-35436 PR:000016672 denotes Trip13
T6110 35442-35455 CL:0000017 denotes spermatocytes
T6111 35479-35481 GO:0007132 denotes MI
T6112 35543-35552 GO:0000239 denotes pachytene
T6113 35553-35566 CL:0000017 denotes spermatocytes
T6114 35628-35637 CHEBI:4911 denotes etoposide
T6115 35697-35706 GO:0000239 denotes pachynema
T6116 35716-35726 GO:0000075 denotes checkpoint
T6117 35763-35765 CHEBI:44658 denotes OA
T6118 35784-35799 GO:0042148 denotes strand invasion
T6119 35811-35817 PR:000016672 denotes TRIP13
T6120 35828-35841 CL:0000017 denotes spermatocytes
T6121 35850-35856 PR:000016672 denotes TRIP13
T6122 35908-35911 NCBITaxon:10114 denotes rat
T6123 35912-35919 UBERON:0002046 denotes thyroid
T6124 35912-35933 PR:000016321 denotes thyroid receptor beta
T6125 35935-35939 PR:000016321 denotes THRB
T6126 35977-35981 PR:000016321 denotes THRB
T6127 35986-35992 PR:000016672 denotes TRIP13
T6128 35996-36003 GO:0007126 denotes meiosis
T6129 36048-36052 PR:000016321 denotes THRB
T6130 36099-36111 CL:0000017 denotes spermatocyte
T6131 36112-36118 GO:0005634 denotes nuclei
T6132 36144-36146 _FRAGMENT denotes XY
T6133 36153-36157 GO:0001741 denotes body
T6134 36148-36151 _FRAGMENT denotes sex
T6135 36206-36213 GO:0005634 denotes nuclear
T6136 36234-36243 GO:0000239 denotes pachynema
T6137 36258-36273 GO:0000803 denotes sex chromosomes
T6138 36281-36300 GO:0031507 denotes heterochromatinized
T6139 36305-36331 GO:0006342 denotes transcriptionally silenced
T6140 36374-36381 GO:0001741 denotes XY body
T6141 36413-36426 CL:0000017 denotes spermatocytes
T6142 36464-36466 GO:0001741 denotes XY
T6143 36467-36489 GO:0031507 denotes heterochromatinization
T6144 36535-36539 PR:000016321 denotes THRB
T6145 36549-36553 NCBITaxon:10088 denotes mice
T6146 36619-36625 PR:000016672 denotes TRIP13
T6147 36643-36647 PR:000016321 denotes THRB
T6148 36651-36658 GO:0007126 denotes meiosis
T6149 36700-36704 PR:P38126 denotes PCH2
T6150 36705-36714 SO:0000855 denotes orthologs
T6151 36730-36740 NCBITaxon:2759 denotes eukaryotic
T6152 36821-36827 PR:000016672 denotes TRIP13
T6153 36845-36855 GO:0000075 denotes checkpoint
T6154 36868-36872 NCBITaxon:10088 denotes mice
T6155 36894-36900 PR:000016672 denotes TRIP13
T6156 36901-36905 PR:P38126 denotes PCH2
T6157 36995-37006 NCBITaxon:3702 denotes A. thaliana
T6158 37033-37051 GO:0033313 denotes meiotic checkpoint
T6159 37119-37128 NCBITaxon:1 denotes organisms
T6173 37488-37494 NCBITaxon:3193 denotes plants
T6174 37541-37551 GO:0000075 denotes checkpoint
T6175 37615-37622 NCBITaxon:33208 denotes animals
T6176 37624-37629 NCBITaxon:4751 denotes fungi
T6177 37635-37641 NCBITaxon:3193 denotes plants
T6178 37669-37673 PR:P38126 denotes PCH2
T6179 37762-37772 GO:0000075 denotes checkpoint
T6180 37786-37790 PR:P38126 denotes PCH2
T6181 37836-37846 GO:0000075 denotes checkpoint
T6182 37891-37898 GO:0007114 denotes budding
T6183 37891-37904 NCBITaxon:4892 denotes budding yeast
T6184 37957-37961 PR:P38126 denotes PCH2
T6185 37971-37980 NCBITaxon:1 denotes organisms
T6186 38014-38022 GO:0007129 denotes synapsis
T6187 38023-38033 GO:0000075 denotes checkpoint
T6188 38042-38046 NCBITaxon:10088 denotes mice
T6189 38095-38099 PR:Q9SIH2 denotes Dot1
T6190 38101-38105 PR:Q04089 denotes PCH1
T6191 38119-38126 PR:000043452 denotes histone
T6192 38119-38126 CHEBI:15358 denotes histone
T6193 38145-38154 GO:0016458 denotes silencing
T6194 38183-38192 GO:0000239 denotes pachytene
T6195 38203-38207 PR:P31111 denotes zip1
T6196 38212-38216 PR:000006536 denotes dmc1
T6197 38259-38264 PR:000013680 denotes RAD54
T6198 38274-38289 _FRAGMENT denotes recombinational
T6199 38294-38300 GO:0000725 denotes repair
T6200 38290-38300 GO:0006302 denotes DSB repair
T6201 38337-38341 PR:Q9SIH2 denotes DOT1
T6202 38359-38363 PR:P38126 denotes PCH2
T6203 38376-38382 PR:000016672 denotes TRIP13
T6204 38396-38406 GO:0000075 denotes checkpoint
T6205 38419-38423 NCBITaxon:10088 denotes mice
T6206 38446-38455 NCBITaxon:40674 denotes mammalian
T6207 38456-38460 PR:Q9SIH2 denotes DOT1
T6208 38468-38488 GO:0051598 denotes pachytene checkpoint
T6209 38558-38563 PR:000003035 denotes TRP53
T6210 38564-38571 SO:0000853 denotes homolog
T6211 38572-38577 PR:000016567 denotes TRP63
T6212 38613-38618 GO:0016265 denotes death
T6213 38637-38655 CL:0000654 denotes primordial oocytes
T6214 38706-38716 GO:0065007 denotes monitoring
T6215 38717-38723 SO:0001026 denotes genome
T6216 38786-38806 GO:0051598 denotes pachytene checkpoint
T6217 38877-38895 GO:0033313 denotes meiotic checkpoint
T6218 38896-38901 SO:0000704 denotes genes
T6219 38905-38909 NCBITaxon:10088 denotes mice
T6220 38936-38941 SO:0000704 denotes genes
T6221 38953-38960 GO:0007067 denotes mitotic
T6222 38980-38985 PR:P32641 denotes RAD24
T6223 39044-39053 NCBITaxon:40674 denotes mammalian
T6224 39054-39074 GO:0051598 denotes pachytene checkpoint
T6225 39091-39100 SO:0000855 denotes orthologs
T6226 39127-39136 NCBITaxon:1 denotes organisms
T8136 39545-39547 SO:0000028 denotes bp
T8244 39657-39663 PR:000016672 denotes Trip13
T8245 39674-39678 NCBITaxon:10088 denotes mice
T8246 39684-39689 NCBITaxon:10088 denotes mouse
T8247 39690-39699 UBERON:0000922 denotes embryonic
T8248 39690-39709 CL:0002322 denotes embryonic stem cell
T8249 39752-39756 SO:0000704 denotes gene
T8250 39775-39781 PR:000016672 denotes Trip13
T8251 39852-39856 SO:0000704 denotes gene
T8252 39866-39872 SO:0000440 denotes vector
T8253 39934-39942 SO:0001817 denotes in-frame
T8254 39965-39970 SO:0000147 denotes exons
T8255 39986-39990 SO:0000704 denotes gene
T8256 40045-40053 CHEBI:7507 denotes neomycin
T8257 40082-40086 SO:0000704 denotes gene
T8258 40111-40128 SO:0001886 denotes fusion transcript
T8259 40140-40145 SO:0000147 denotes exons
T8260 40153-40159 PR:000016672 denotes Trip13
T8261 40192-40206 SO:0000366 denotes insertion site
T8262 40214-40220 SO:0000188 denotes intron
T8263 40252-40258 SO:0000112 denotes primer
T8264 40270-40274 SO:0000704 denotes gene
T8265 40280-40286 SO:0000440 denotes vector
T8266 40302-40308 SO:0000112 denotes primer
T8267 40333-40339 SO:0000188 denotes intron
T8268 40377-40381 SO:0000704 denotes gene
T8269 40452-40466 SO:0000366 denotes insertion site
T8270 40475-40477 SO:0000028 denotes bp
T8271 40483-40489 SO:0000188 denotes intron
T8478 40508-40512 NCBITaxon:10088 denotes mice
T8479 40520-40527 SO:0000112 denotes primers
T8480 40574-40581 SO:0001023 denotes alleles
T8481 40585-40591 PR:000016672 denotes Trip13
T8482 40593-40599 SO:0000112 denotes primer
T8483 40632-40638 SO:0000112 denotes primer
T8484 40687-40693 SO:0000112 denotes primer
T8485 40728-40735 SO:0000112 denotes Primers
T8486 40802-40806 SO:0000704 denotes gene
T8487 40833-40839 SO:0000188 denotes intron
T8488 40843-40849 SO:0000112 denotes Primer
T8489 40884-40891 SO:0000112 denotes Primers
T8490 40914-40916 SO:0000028 denotes bp
T8491 40939-40945 SO:0001023 denotes allele
T8492 40947-40954 SO:0000112 denotes primers
T8493 40977-40979 SO:0000028 denotes bp
T8494 41003-41009 SO:0001023 denotes allele
T8694 41257-41262 UBERON:0007023 denotes adult
T8695 41263-41269 UBERON:0000473 denotes testes
T8696 41363-41382 GO:0001171 denotes reverse-transcribed
T8697 41455-41461 PR:000016672 denotes Trip13
T8698 41462-41476 SO:0000010 denotes protein-coding
T8699 41505-41512 SO:0000112 denotes primers
T8700 41683-41690 SO:0000112 denotes primers
T8701 41710-41715 PR:000010303 denotes Med31
T8890 41971-41978 NCBITaxon:9031 denotes chicken
T8891 41979-41989 GO:0042571 denotes antibodies
T8892 42039-42045 PR:000016672 denotes TRIP13
T8893 42068-42078 MOP:0000779 denotes conjugated
T8894 42107-42115 NCBITaxon:9031 denotes chickens
T8895 42181-42184 GO:0071760 denotes IgY
T8896 42203-42207 UBERON:0007379 denotes eggs
T8897 42228-42235 NCBITaxon:9031 denotes Chicken
T8898 42236-42239 GO:0071760 denotes IgY
T8899 42293-42296 GO:0071760 denotes IgY
T8900 42297-42307 GO:0042571 denotes antibodies
T8991 42404-42410 UBERON:0000473 denotes testis
T8992 42454-42457 CHEBI:8984 denotes SDS
T8993 42498-42512 CHEBI:53325 denotes Nitrocellulose
T8994 42601-42607 NCBITaxon:9986 denotes rabbit
T8995 42613-42618 NCBITaxon:9606 denotes human
T8996 42619-42625 PR:000016672 denotes TRIP13
T8997 42626-42634 GO:0042571 denotes antibody
T8998 42720-42729 CHEBI:60816 denotes immunogen
T8999 42803-42807 SO:0000147 denotes exon
T9000 42878-42884 NCBITaxon:9986 denotes rabbit
T9001 42890-42897 NCBITaxon:9031 denotes chicken
T9002 42898-42901 GO:0071735 denotes IgG
T9003 42902-42913 NCBITaxon:3704 denotes horseradish
T9004 42925-42934 CHEBI:64985 denotes conjugate
T9219 43369-43382 CL:0000017 denotes spermatocytes
T9220 43387-43394 CL:0000023 denotes oocytes
T9221 43545-43551 GO:0005634 denotes nuclei
T9222 43566-43580 GO:0098762 denotes meiotic stages
T9223 43652-43657 PR:000015865 denotes SYCP3
T9224 43661-43666 PR:000015706 denotes STAG3
T9225 43793-43798 PR:000013672 denotes RAD51
T9226 43802-43805 GO:0005662 denotes RPA
T9227 43980-43984 PR:000010442 denotes MLH1
T9228 43988-43992 PR:000010443 denotes MLH3
T9229 43998-44003 PR:000013672 denotes RAD51
T9230 44019-44024 PR:000015865 denotes SYCP3
T9231 44028-44033 PR:000015706 denotes STAG3
T9232 44079-44085 GO:0005634 denotes Nuclei
T9233 44129-44133 PR:000010442 denotes MLH1
T9234 44207-44217 GO:0042571 denotes antibodies
T9235 44254-44259 NCBITaxon:10088 denotes mouse
T9236 44265-44269 PR:000015865 denotes SCP3
T9237 44308-44314 NCBITaxon:9986 denotes rabbit
T9238 44320-44325 PR:000015862 denotes SYCP1
T9239 44366-44372 NCBITaxon:9986 denotes rabbit
T9240 44378-44382 PR:000013858 denotes REC8
T9241 44416-44422 NCBITaxon:9986 denotes rabbit
T9242 44428-44433 PR:000013672 denotes RAD51
T9243 44458-44466 GO:0042571 denotes antibody
T9244 44483-44488 PR:000013672 denotes RAD51
T9245 44493-44497 PR:000006536 denotes DMC1
T9246 44563-44569 NCBITaxon:9986 denotes rabbit
T9247 44638-44644 NCBITaxon:9986 denotes rabbit
T9248 44650-44655 PR:000015706 denotes STAG3
T9249 44694-44700 NCBITaxon:9986 denotes rabbit
T9250 44706-44710 PR:000010443 denotes MLH3
T9251 44742-44747 NCBITaxon:10088 denotes mouse
T9252 44753-44758 NCBITaxon:9606 denotes human
T9253 44759-44763 PR:000010442 denotes MLH1
T9254 44818-44824 NCBITaxon:9986 denotes rabbit
T9255 44830-44836 PR:000016548 denotes TopBP1
T9256 44872-44877 NCBITaxon:10088 denotes mouse
T9257 44893-44900 CHEBI:15358 denotes histone
T9258 44893-44904 PR:000027547 denotes histone H2A
T9259 44937-44943 NCBITaxon:9986 denotes rabbit
T9260 44949-44953 PR:000016236 denotes TRF2
T9261 44992-44998 NCBITaxon:9986 denotes rabbit
T9262 45004-45007 PR:000004759 denotes BLM
T9263 45053-45063 GO:0042571 denotes antibodies
T9264 45064-45074 MOP:0000779 denotes conjugated
T9265 45087-45102 CHEBI:52661 denotes Alexa Fluor 488
T9266 45087-45098 _FRAGMENT denotes Alexa Fluor
T9267 45106-45109 CHEBI:51248 denotes 594
T9724 45267-45278 GO:0007132 denotes Metaphase I
T9725 45279-45291 CL:0000017 denotes spermatocyte
T9726 45304-45306 CHEBI:44658 denotes OA
T9727 45318-45327 GO:0051323 denotes Metaphase
T9728 45334-45347 CL:0000017 denotes spermatocytes
T9729 45362-45368 PR:000016672 denotes Trip13
T9730 45413-45417 NCBITaxon:10088 denotes mice
T9731 45491-45493 CHEBI:44658 denotes OA
T9732 45532-45534 CHEBI:44658 denotes OA
T9733 45630-45633 CHEBI:16526 denotes CO2
T9734 45694-45698 CHEBI:51231 denotes DAPI
T9735 45712-45721 GO:0051323 denotes metaphase
T9736 45722-45728 GO:0005634 denotes nuclei
T9850 45770-45776 PR:000016672 denotes TRIP13
T9851 45777-45786 SO:0000855 denotes orthologs
T9852 45861-45865 SO:0000704 denotes gene
T9853 45903-45912 SO:0000855 denotes orthologs
T9854 46086-46092 SO:0000417 denotes domain
T9855 46283-46287 SO:0000730 denotes gaps
T9984 7433-7438 NCBITaxon:10088 denotes Mouse
T9985 7439-7443 PR:P38126 denotes PCH2
T9986 7444-7452 SO:0000855 denotes Ortholog
T9987 7453-7459 PR:000016672 denotes TRIP13
T9988 7464-7474 GO:0010467 denotes Expression
T9989 7533-7537 PR:P38126 denotes PCH2
T9990 7538-7544 PR:000016672 denotes TRIP13
T9991 7545-7554 SO:0000855 denotes orthologs
T9992 7892-7902 NCBITaxon:2759 denotes eukaryotic
T9993 7939-7952 NCBITaxon:33511 denotes deuterostomia
T9994 7962-7968 NCBITaxon:3193 denotes plants
T9995 7979-7990 NCBITaxon:33317 denotes protostomia
T9996 8006-8011 NCBITaxon:4751 denotes fungi
T9997 8077-8084 UBERON:0000479 denotes tissues
T9998 8089-8094 UBERON:0000948 denotes heart
T9999 8099-8104 UBERON:0000955 denotes brain
T10000 8109-8115 UBERON:0002106 denotes spleen
T10001 8120-8124 UBERON:0002048 denotes lung
T10002 8129-8134 UBERON:0002107 denotes liver
T10003 8139-8147 UBERON:0004288 denotes skeletal
T10004 8159-8165 UBERON:0002113 denotes kidney
T10005 8170-8176 UBERON:0000473 denotes testis
T10006 8184-8190 UBERON:0000922 denotes embryo
T10007 8200-8206 UBERON:0000922 denotes embryo
T10008 8216-8222 UBERON:0000922 denotes embryo
T10009 8236-8242 UBERON:0000922 denotes embryo
T10010 8248-8254 SO:0000188 denotes Intron
T10011 8255-8259 SO:0000147 denotes exon
T10012 8273-8279 PR:000016672 denotes TRIP13
T10013 8284-8298 SO:0000366 denotes insertion site
T10014 8302-8306 SO:0000704 denotes gene
T10015 8312-8318 SO:0000440 denotes vector
T10016 8377-8391 SO:0000366 denotes insertion site
T10017 8422-8428 PR:000016672 denotes Trip13
T10018 8443-8447 SO:0000704 denotes gene
T10019 8448-8453 PR:000010303 denotes Med31
T10020 8459-8465 UBERON:0000473 denotes testis
T10021 8475-8481 PR:000016672 denotes Trip13
T10022 8482-8489 SO:0000112 denotes primers
T10023 8525-8530 SO:0000147 denotes exons
T10024 8589-8595 UBERON:0000473 denotes testis
T10025 8614-8620 PR:000016672 denotes TRIP13
T10026 8621-8629 GO:0042571 denotes antibody
T10027 8673-8680 PR:000028799 denotes tubulin
T10028 8722-8728 PR:000016672 denotes TRIP13
T10029 8769-8775 PR:000016672 denotes TRIP13
T10030 8779-8785 UBERON:0000473 denotes testes
T10031 8823-8829 UBERON:0000473 denotes testis
T10032 8856-8863 NCBITaxon:9031 denotes chicken
T10033 8869-8875 PR:000016672 denotes TRIP13
T10034 8899-8909 MOP:0000779 denotes conjugated
T10035 8915-8922 NCBITaxon:9031 denotes chicken
T10036 8923-8926 GO:0071735 denotes IgG
T10037 8949-8959 GO:0010467 denotes Expression
T10038 8992-8998 GO:0005634 denotes nuclei
T10039 9009-9022 CL:0000020 denotes spermatogonia
T10040 9024-9026 CL:0000020 denotes Sg
T10041 9029-9038 GO:0000237 denotes leptotene
T10042 9039-9052 CL:0000017 denotes spermatocytes
T10043 9069-9078 GO:0000239 denotes pachytene
T10044 9079-9092 CL:0000017 denotes spermatocytes
T10045 9112-9121 GO:0000239 denotes pachytene
T10046 9122-9135 CL:0000017 denotes spermatocytes
T10047 9145-9152 GO:0005634 denotes nuclear
T10048 9181-9187 UBERON:0000473 denotes testis
T10049 9215-9226 GO:0005737 denotes cytoplasmic
T10050 9316-9326 UBERON:0000483 denotes epithelial
T10051 9340-9347 UBERON:0000025 denotes tubules
T10052 9371-9377 PR:000016672 denotes TRIP13
T10053 9409-9422 CL:0000017 denotes spermatocytes
T10054 9466-9471 PR:000015865 denotes SYCP3
T10055 9473-9474 PR:000015865 denotes S
T10056 9480-9486 PR:000016672 denotes TRIP13
T10057 9488-9489 PR:000016672 denotes T
T10058 9540-9549 GO:0000237 denotes leptotene
T10059 9551-9554 GO:0000237 denotes Lep
T10060 9557-9565 GO:0000238 denotes zygotene
T10061 9567-9570 GO:0000238 denotes Zyg
T10062 9577-9586 GO:0000239 denotes pachytene
T10063 9588-9591 GO:0000239 denotes Pac
T10064 9593-9606 CL:0000017 denotes spermatocytes
T10065 9608-9615 GO:0005634 denotes Nuclear
T10648 10410-10416 PR:000016672 denotes Trip13
T10649 10424-10428 NCBITaxon:10088 denotes Mice
T10650 10484-10488 UBERON:0002415 denotes tail
T10651 10615-10619 UBERON:0002415 denotes tail
T10652 10647-10652 NCBITaxon:10088 denotes mouse
T10653 10695-10701 PR:000016672 denotes Trip13
T10654 10715-10721 UBERON:0000473 denotes testes
T10655 10815-10821 PR:000016672 denotes Trip13
T10656 10822-10828 UBERON:0000473 denotes testes
T10657 10856-10863 UBERON:0000025 denotes tubules
T10658 10887-10902 GO:0007283 denotes spermatogenesis
T10659 10908-10917 GO:0000239 denotes pachytene
T10660 10918-10931 CL:0000017 denotes spermatocytes
T10661 10947-10954 UBERON:0000025 denotes tubules
T10662 11048-11055 UBERON:0000025 denotes tubules
T10663 11062-11069 UBERON:0000025 denotes tubules
T10664 11078-11087 GO:0000239 denotes pachytene
T10665 11088-11100 CL:0000017 denotes spermatocyes
T10876 13802-13808 UBERON:0000991 denotes Gonads
T10877 13817-13828 CHEBI:51686 denotes hematoxylin
T10878 13862-13868 UBERON:0000473 denotes Testes
T10879 13944-13949 UBERON:0000992 denotes ovary
T10880 13955-13961 PR:000016672 denotes Trip13
T10881 13977-13982 UBERON:0000992 denotes ovary
T10882 14022-14029 CL:0000023 denotes oocytes
T10883 14035-14041 PR:000016672 denotes Trip13
T10884 14062-14067 UBERON:0000992 denotes ovary
T10885 14085-14092 CL:0000023 denotes oocytes
T10886 14125-14131 PR:000016672 denotes Trip13
T10887 14145-14150 UBERON:0000992 denotes ovary
T10888 14176-14183 CL:0000023 denotes oocytes
T10889 14251-14257 UBERON:0000473 denotes testis
T10890 14263-14269 PR:000016672 denotes Trip13
T10891 14275-14281 UBERON:0000473 denotes testis
T10892 14295-14304 GO:0000239 denotes pachytene
T10893 14317-14323 PR:000016672 denotes Trip13
T10894 14338-14344 UBERON:0000473 denotes testis
T10895 14359-14366 GO:0007126 denotes meiotic
T10896 14367-14377 CL:0000018 denotes spermatids
T10897 14392-14397 PR:000015553 denotes Spo11
T10898 14401-14407 UBERON:0000473 denotes testis
T10899 14411-14417 UBERON:0000025 denotes tubule
T10900 14423-14436 CL:0000017 denotes spermatocytes
T10901 14440-14449 GO:0000237 denotes leptotene
T10902 14450-14458 GO:0000238 denotes zygotene
T10903 14489-14496 UBERON:0000025 denotes tubules
T10904 14512-14525 CL:0000017 denotes spermatocytes
T10905 14616-14621 PR:000015553 denotes Spo11
T10906 14626-14632 PR:000016672 denotes Trip13
T10907 14638-14644 UBERON:0000473 denotes testis
T10908 14699-14705 UBERON:0000025 denotes tubule
T10909 14711-14720 GO:0000237 denotes leptotene
T10910 14721-14729 GO:0000238 denotes zygotene
T10911 14730-14743 CL:0000017 denotes spermatocytes
T10912 14749-14753 PR:000031227 denotes Mei1
T10913 14758-14764 PR:000016672 denotes Trip13
T10914 14769-14775 UBERON:0000473 denotes testis
T10915 14838-14842 PR:000031227 denotes Mei1
T10916 14847-14853 PR:000016672 denotes Trip13
T10917 14859-14865 UBERON:0000473 denotes testis
T10918 14871-14875 PR:000013858 denotes Rec8
T10919 14880-14884 PR:000013858 denotes Rec8
T10920 14889-14895 PR:000016672 denotes Trip13
T10940 15321-15325 PR:000031227 denotes Mei1
T10941 15330-15336 PR:000016672 denotes Trip13
T10942 15351-15356 UBERON:0000992 denotes ovary
T10943 15362-15366 PR:000013858 denotes Rec8
T10944 15371-15375 PR:000013858 denotes Rec8
T10945 15380-15386 PR:000016672 denotes Trip13
T10946 15400-15405 UBERON:0000992 denotes ovary
T10947 15468-15472 PR:000013858 denotes Rec8
T10948 15477-15481 PR:000013858 denotes Rec8
T10949 15486-15492 PR:000016672 denotes Trip13
T10950 15507-15512 UBERON:0000992 denotes ovary
T11576 18075-18080 PR:000015865 denotes SYCP3
T11577 18110-18123 CL:0000017 denotes Spermatocytes
T11578 18124-18131 GO:0005634 denotes nucleus
T11579 18148-18154 GO:0007567 denotes partum
T11580 18164-18172 GO:0007129 denotes synapsed
T11581 18311-18320 GO:0000239 denotes pachytene
T11582 18321-18334 CL:0000017 denotes spermatocytes
T11583 18340-18343 PR:000004759 denotes BLM
T11584 18364-18372 GO:0007129 denotes synapsed
T11585 18373-18382 GO:0000239 denotes pachytene
T11586 18414-18419 PR:000013672 denotes RAD51
T11587 18456-18464 GO:0051324 denotes prophase
T11588 18481-18490 GO:0030849 denotes autosomes
T11589 18504-18513 GO:0000239 denotes pachytene
T11590 18514-18520 GO:0005634 denotes nuclei
T11591 18562-18569 GO:0001741 denotes XY body
T11592 18583-18588 PR:000013672 denotes RAD51
T11593 18605-18613 GO:0007129 denotes synapsed
T11594 18647-18651 PR:000008418 denotes H2AX
T11595 18689-18696 GO:0001741 denotes XY body
T11596 18771-18778 GO:0001741 denotes XY body
T11597 18799-18808 GO:0030849 denotes autosomal
T11598 18809-18813 PR:000008418 denotes H2AX
T11599 18870-18879 GO:0000239 denotes pachytene
T11600 18880-18893 CL:0000017 denotes spermatocytes
T11601 18895-18901 PR:000016548 denotes TOPBP1
T11602 18927-18934 GO:0001741 denotes XY body
T11603 19039-19054 GO:0000803 denotes sex chromosomes
T11604 19119-19122 GO:0005662 denotes RPA
T11605 19138-19146 GO:0007129 denotes synapsed
T11606 19211-19215 PR:000010443 denotes MLH3
T11607 19224-19227 GO:0000795 denotes SCs
T11608 19244-19253 GO:0000239 denotes pachytene
T11609 19254-19267 CL:0000017 denotes spermatocytes
T11610 19269-19274 PR:000013672 denotes RAD51
T11611 19338-19343 PR:000013672 denotes RAD51
T11612 19364-19367 GO:0000795 denotes SCs
T11613 19378-19387 GO:0000239 denotes pachytene
T11614 19388-19394 GO:0005634 denotes nuclei
T11615 19422-19426 PR:000010442 denotes MLH1
T12115 27034-27040 PR:000016672 denotes Trip13
T12116 27123-27133 GO:0042571 denotes antibodies
T9129 42969-42975 UBERON:0000473 denotes Testes
T9130 42979-42986 UBERON:0000992 denotes ovaries
T9131 43066-43077 CHEBI:51686 denotes hematoxylin
T9132 43089-43096 CHEBI:59132 denotes Antigen
T9133 43135-43141 UBERON:0000473 denotes testis
T12117 27138-27150 CHEBI:51217 denotes fluorophores
T12118 27307-27313 GO:0005634 denotes nuclei
T2239 16062-16072 CL:0000018 denotes spermatids
T2240 16112-16122 UBERON:0001301 denotes epididymal
T2241 16123-16128 CL:0000019 denotes sperm
T2242 16144-16151 GO:0007126 denotes meiotic
T2243 16191-16201 NCBITaxon:6239 denotes C. elegans
T2244 16224-16228 PR:P38126 denotes Pch2
T2245 16256-16261 CL:0002369 denotes spore
T2246 16256-16261 _FRAGMENT denotes spore
T2247 16269-16280 GO:0030435 denotes development
T2248 16262-16268 CL:0000300 denotes gamete
T2249 16262-16280 GO:0007276 denotes gamete development
T11565 17678-17687 GO:0000239 denotes Pachytene
T11566 17688-17700 CL:0000017 denotes Spermatocyte
T8129 39239-39245 PR:000016672 denotes Trip13
T8130 39252-39258 PR:000016672 denotes Trip13
T8131 39300-39305 NCBITaxon:10088 denotes Mouse
T8132 39315-39321 UBERON:0000479 denotes Tissue
T8133 39382-39389 SO:0000112 denotes primers
T8134 39476-39483 SO:0000112 denotes primers
T8135 39498-39503 SO:0000147 denotes exons
T9134 43174-43180 CL:0000023 denotes Oocyte
T9135 43263-43269 CL:0000023 denotes oocyte
T9136 43293-43300 GO:0005634 denotes nucleus
T1 0-5 NCBITaxon:10088 denotes Mouse
T2 6-26 GO:0051598 denotes Pachytene Checkpoint
T3 6-28 PR:P38126 denotes Pachytene Checkpoint 2
T11567 17778-17788 GO:0042571 denotes antibodies
T2207 12995-13002 GO:0007126 denotes Meiotic
T2208 13017-13023 PR:000016672 denotes TRIP13
T2209 13080-13086 UBERON:0000991 denotes gonads
T2210 13139-13146 UBERON:0000992 denotes Ovaries
T2211 13150-13155 UBERON:0007023 denotes adult
T2212 13156-13162 PR:000016672 denotes Trip13
T2213 13265-13271 CL:0000023 denotes oocyte
T2214 13294-13307 GO:0009790 denotes embryogenesis
T2215 13324-13329 GO:0007567 denotes natal
T2216 13357-13363 GO:0007567 denotes partum
T2217 13364-13371 UBERON:0000992 denotes ovaries
T2218 13446-13453 CL:0000023 denotes oocytes
T2219 13507-13514 CL:0000023 denotes oocytes
T2220 13585-13592 CL:0000023 denotes oocytes
T2221 13598-13607 GO:0000239 denotes pachytene
T2222 13636-13642 PR:000016672 denotes Trip13
T2223 13648-13657 UBERON:0000922 denotes embryonic
T2224 13658-13665 UBERON:0000992 denotes ovaries
T2225 13706-13713 CL:0000023 denotes oocytes
T2226 13748-13757 GO:0000239 denotes pachynema
T10921 14900-14906 UBERON:0000473 denotes testis
T10922 14912-14916 PR:000013858 denotes Rec8
T10923 14921-14927 SO:0001023 denotes allele
T10924 15009-15013 PR:000013858 denotes Rec8
T10925 15018-15022 PR:000013858 denotes Rec8
T10926 15027-15033 PR:000016672 denotes Trip13
T10927 15039-15045 UBERON:0000473 denotes testis
T10928 15051-15055 PR:000006536 denotes Dmc1
T10929 15060-15066 PR:000016672 denotes Trip13
T10930 15072-15078 UBERON:0000473 denotes testis
T10931 15084-15089 PR:000015553 denotes Spo11
T10932 15094-15100 PR:000016672 denotes Trip13
T10933 15114-15119 UBERON:0000992 denotes ovary
T10934 15182-15187 PR:000015553 denotes Spo11
T10935 15192-15198 PR:000016672 denotes Trip13
T10936 15213-15218 UBERON:0000992 denotes ovary
T10937 15224-15228 PR:000031227 denotes Mei1
T10938 15233-15239 PR:000016672 denotes Trip13
T10939 15253-15258 UBERON:0000992 denotes ovary
T2227 15546-15552 UBERON:0000473 denotes testes
T2228 15576-15583 GO:0007126 denotes meiotic
T2229 15632-15652 UBERON:0001343 denotes seminiferous tubules
T2230 15700-15720 UBERON:0001343 denotes seminiferous tubules
T2231 15741-15754 CL:0000017 denotes spermatocytes
T2232 15770-15779 GO:0000785 denotes chromatin
T2233 15798-15807 GO:0000239 denotes pachynema
T2234 15848-15861 GO:0007283 denotes spermatogenic
T2235 15911-15920 GO:0000239 denotes pachytene
T2236 16013-16018 UBERON:0007023 denotes adult
T2237 16019-16039 UBERON:0001343 denotes seminiferous tubules
T2238 16054-16061 GO:0007126 denotes meiotic
T11568 17793-17805 CHEBI:51217 denotes fluorophores
T11569 17899-17905 PR:000016672 denotes Trip13
T11570 17914-17920 PR:000016672 denotes Trip13
T11571 17994-18007 CL:0000017 denotes spermatocytes
T11572 18022-18031 GO:0000239 denotes pachytene
T11573 18032-18039 GO:0005634 denotes nucleus
T11574 18050-18058 GO:0007129 denotes synapsis
T11575 18069-18074 PR:000015862 denotes SYCP1
T1565 9666-9672 PR:000016672 denotes Trip13
T1566 9680-9684 NCBITaxon:10088 denotes Mice
T1567 9712-9718 PR:000016672 denotes TRIP13
T1568 9722-9729 NCBITaxon:40674 denotes mammals
T1569 9744-9748 NCBITaxon:10088 denotes mice
T1570 9756-9760 SO:0000704 denotes gene
T1571 9776-9782 SO:0001023 denotes allele
T1572 9784-9790 PR:000016672 denotes Trip13
T1573 9824-9830 PR:000016672 denotes Trip13
T1574 9978-9984 PR:000016672 denotes Trip13
T1575 9994-10000 PR:000016672 denotes Trip13
T1576 10013-10019 PR:000016672 denotes Trip13
T1577 10049-10053 NCBITaxon:10088 denotes mice
T1578 10059-10063 GO:0016265 denotes died
T1579 10175-10181 PR:000016672 denotes Trip13
T1580 10187-10194 NCBITaxon:33208 denotes animals
T1583 11201-11211 GO:0010467 denotes expression
T2624 17405-17414 GO:0000239 denotes pachynema
T2588 16289-16295 PR:000016672 denotes TRIP13
T2589 16324-16354 GO:0007129 denotes Homologous Chromosome Synapsis
T2590 16381-16389 GO:0006281 denotes repaired
T2591 16398-16407 GO:0000239 denotes Pachynema
T2592 16445-16452 GO:0007126 denotes meiotic
T2593 16468-16474 PR:000016672 denotes Trip13
T2594 16480-16493 CL:0000017 denotes spermatocytes
T2595 16535-16540 PR:000015865 denotes SYCP3
T2596 16545-16550 PR:000015862 denotes SYCP1
T2597 16570-16575 _FRAGMENT denotes axial
T2598 16584-16592 GO:0000800 denotes elements
T2599 16576-16592 GO:0000800 denotes lateral elements
T2600 16597-16617 GO:0000802 denotes transverse filaments
T2601 16640-16660 GO:0000795 denotes synaptonemal complex
T2602 16662-16664 GO:0000795 denotes SC
T2603 16667-16676 GO:0000239 denotes Pachytene
T2604 16677-16689 CL:0000017 denotes spermatocyte
T2605 16690-16696 GO:0005634 denotes nuclei
T2606 16722-16728 UBERON:0000473 denotes testes
T2607 16751-16753 GO:0000795 denotes SC
T2608 16779-16802 GO:0007129 denotes synapsis of chromosomes
T2609 16830-16835 PR:000015862 denotes SYCP1
T2610 16840-16845 PR:000015865 denotes SYCP3
T2611 16876-16885 GO:0030849 denotes autosomes
T2612 16917-16918 _FRAGMENT denotes X
T2613 16925-16936 GO:0000805 denotes chromosomes
T2614 16923-16936 GO:0000806 denotes Y chromosomes
T2615 16951-16959 GO:0007129 denotes synapsed
T2616 17022-17028 GO:0007567 denotes partum
T2617 17037-17050 CL:0000017 denotes spermatocytes
T2618 17062-17070 GO:0007129 denotes synaptic
T2619 17086-17094 GO:0007129 denotes synapsed
T2620 17232-17237 GO:0007567 denotes natal
T2621 17238-17253 GO:0007283 denotes spermatogenesis
T2622 17367-17373 PR:000016672 denotes Trip13
T2623 17379-17392 CL:0000017 denotes spermatocytes
T2625 17429-17431 GO:0000795 denotes SC
T2626 17451-17458 CL:0000023 denotes oocytes
T2627 17486-17491 GO:0007567 denotes birth
T2628 17513-17523 GO:0006281 denotes DNA repair
T2629 17561-17569 GO:0006281 denotes repaired
T2630 17604-17611 GO:0007126 denotes meiotic
T2631 19524-19526 GO:0005634 denotes lu
T2632 19529-19531 GO:0007567 denotes at
T6160 37137-37141 NCBITaxon:10088 denotes mice
T6161 37143-37150 GO:0007114 denotes budding
T6162 37143-37156 NCBITaxon:4892 denotes budding yeast
T6163 37169-37179 NCBITaxon:7215 denotes Drosophila
T6164 37193-37202 NCBITaxon:40674 denotes mammalian
T6165 37203-37209 PR:000016672 denotes TRIP13
T6166 37229-37240 NCBITaxon:3701 denotes Arabidopsis
T6167 37241-37245 PR:P38126 denotes PCH2
T6168 37255-37258 NCBITaxon:7147 denotes fly
T6169 37329-37338 NCBITaxon:40674 denotes mammalian
T6170 37343-37348 NCBITaxon:3193 denotes plant
T6171 37349-37353 PR:P38126 denotes PCH2
T6172 37480-37484 PR:P38126 denotes PCH2
R1 T6 T5 _lexicallyChainedTo Synapsis,Meiotic
R247 T487 T486 _lexicallyChainedTo checkpoint,pachytene
R248 T511 T510 _lexicallyChainedTo DSBs,repair of
R875 T1347 T1346 _lexicallyChainedTo related,evolutionarily
R876 T1352 T1351 _lexicallyChainedTo tissues,embryonic
R1472 T2247 T2246 _lexicallyChainedTo development,spore
R1735 T2598 T2597 _lexicallyChainedTo elements,axial
R1736 T2613 T2612 _lexicallyChainedTo chromosomes,X
R1737 T2709 T2708 _lexicallyChainedTo chromatin,silencing of
R2645 T4018 T4017 _lexicallyChainedTo SC,degradation of
R3989 T5982 T5981 _lexicallyChainedTo repair,recombinational
R3990 T6027 T6026 _lexicallyChainedTo recombination,CO
R3991 T6069 T6068 _lexicallyChainedTo complexes,disassembly of
R3992 T6078 T6077 _lexicallyChainedTo complex disassembly,protein
R3993 T6104 T6103 _lexicallyChainedTo checkpoint,DNA damage
R3994 T6133 T6132 _lexicallyChainedTo body,XY
R3995 T6133 T6134 _lexicallyChainedTo body,sex
R3996 T6199 T6198 _lexicallyChainedTo repair,recombinational
R6258 T9267 T9266 _lexicallyChainedTo 594,Alexa Fluor

2_test

Id Subject Object Predicate Lexical cue
17696610-10559962-85497881 4144-4145 10559962 denotes 1
17696610-16339446-85497881 4144-4145 16339446 denotes 1
17696610-15338235-85497881 4144-4145 15338235 denotes 1
17696610-9334324-85497881 4144-4145 9334324 denotes 1
17696610-10973068-85497882 4378-4379 10973068 denotes 5
17696610-10973068-85497883 4497-4498 10973068 denotes 5
17696610-16546077-85497884 4624-4625 16546077 denotes 6
17696610-8893012-85497884 4624-4625 8893012 denotes 6
17696610-10319812-85497884 4624-4625 10319812 denotes 6
17696610-10619027-85497884 4624-4625 10619027 denotes 6
17696610-16179256-85497884 4624-4625 16179256 denotes 6
17696610-12456752-85497885 4722-4724 12456752 denotes 11
17696610-16339446-85497886 4918-4919 16339446 denotes 2
17696610-17174924-85497887 4920-4922 17174924 denotes 12
17696610-15640358-85497888 5179-5181 15640358 denotes 13
17696610-12004129-85497888 5179-5181 12004129 denotes 13
17696610-12077403-85497888 5179-5181 12077403 denotes 13
17696610-9660953-85497889 5325-5327 9660953 denotes 16
17696610-10319812-85497890 5861-5862 10319812 denotes 8
17696610-16339446-85497891 5996-5997 16339446 denotes 2
17696610-17174924-85497892 5998-6000 17174924 denotes 12
17696610-17174924-85497893 6234-6236 17174924 denotes 12
17696610-17174924-85497894 6859-6861 17174924 denotes 12
17696610-16968779-85497895 7414-7416 16968779 denotes 17
17696610-15515002-85497896 14943-14945 15515002 denotes 39
17696610-16339446-85497897 16282-16283 16339446 denotes 2
17696610-10319812-85497898 16284-16285 10319812 denotes 8
17696610-15640358-85497899 17533-17535 15640358 denotes 13
17696610-11242108-85497900 19871-19873 11242108 denotes 18
17696610-9476899-85497901 20619-20621 9476899 denotes 19
17696610-16530042-85497902 21453-21455 16530042 denotes 20
17696610-17446169-85497903 21456-21458 17446169 denotes 21
17696610-14718568-85497904 21531-21533 14718568 denotes 22
17696610-16055729-85497905 21534-21536 16055729 denotes 23
17696610-11950880-85497906 21690-21692 11950880 denotes 24
17696610-9398850-85497907 21881-21883 9398850 denotes 25
17696610-15580272-85497908 22484-22486 15580272 denotes 27
17696610-15589157-85497908 22484-22486 15589157 denotes 27
17696610-16580996-85497908 22484-22486 16580996 denotes 27
17696610-14704203-85497909 23734-23736 14704203 denotes 30
17696610-10101178-85497910 23737-23739 10101178 denotes 31
17696610-14704203-85497911 23882-23884 14704203 denotes 30
17696610-12091911-85497912 23885-23887 12091911 denotes 32
17696610-7781899-85497913 24872-24874 7781899 denotes 33
17696610-11242108-85497914 25757-25759 11242108 denotes 18
17696610-16339446-85497915 25880-25881 16339446 denotes 2
17696610-11106739-85497916 25975-25977 11106739 denotes 34
17696610-11106738-85497917 25978-25980 11106738 denotes 35
17696610-11686299-85497918 26280-26282 11686299 denotes 36
17696610-14668445-85497919 26922-26924 14668445 denotes 37
17696610-10319812-85497920 27417-27418 10319812 denotes 8
17696610-9590170-85497921 27794-27796 9590170 denotes 38
17696610-15515002-85497922 28217-28219 15515002 denotes 39
17696610-15935783-85497923 28220-28222 15935783 denotes 40
17696610-15515002-85497924 28875-28877 15515002 denotes 39
17696610-15935783-85497925 28878-28880 15935783 denotes 40
17696610-16179256-85497926 28931-28933 16179256 denotes 10
17696610-17174924-85497927 28934-28936 17174924 denotes 12
17696610-10319812-85497928 29082-29083 10319812 denotes 8
17696610-9660953-85497929 29311-29313 9660953 denotes 16
17696610-15640358-85497930 30305-30307 15640358 denotes 13
17696610-15928951-85497931 30308-30310 15928951 denotes 41
17696610-17174924-85497932 31009-31011 17174924 denotes 12
17696610-15297881-85497933 31229-31231 15297881 denotes 42
17696610-16339446-85497934 31350-31351 16339446 denotes 2
17696610-11461701-85497935 32003-32005 11461701 denotes 43
17696610-11461702-85497936 32100-32102 11461702 denotes 44
17696610-15066280-85497937 32103-32105 15066280 denotes 45
17696610-16307920-85497938 32183-32185 16307920 denotes 46
17696610-9409820-85497939 32650-32652 9409820 denotes 47
17696610-10228176-85497940 32653-32655 10228176 denotes 48
17696610-16428451-85497941 32879-32881 16428451 denotes 49
17696610-11779793-85497942 33075-33077 11779793 denotes 50
17696610-16179256-85497943 33226-33228 16179256 denotes 10
17696610-17174924-85497944 33382-33384 17174924 denotes 12
17696610-16980577-85497945 34069-34071 16980577 denotes 51
17696610-9927482-85497946 34311-34313 9927482 denotes 52
17696610-16700071-85497947 35639-35641 16700071 denotes 53
17696610-7776974-85497948 35942-35944 7776974 denotes 54
17696610-15120994-85497949 36356-36358 15120994 denotes 55
17696610-8670802-85497950 36578-36580 8670802 denotes 56
17696610-12456752-85497951 37181-37183 12456752 denotes 11
17696610-12782723-85497952 37184-37186 12782723 denotes 57
17696610-11029058-85497953 38235-38237 11029058 denotes 58
17696610-17122775-85497954 38735-38737 17122775 denotes 59
17696610-8893012-85497955 38987-38988 8893012 denotes 7
17696610-15297881-85497956 39032-39034 15297881 denotes 42
17696610-16822657-85497957 43169-43171 16822657 denotes 60
17696610-15129012-85497958 43229-43231 15129012 denotes 61
17696610-15515002-85497959 43423-43425 15515002 denotes 39
17696610-14769957-85497960 43426-43428 14769957 denotes 62
17696610-1464329-85497961 44361-44363 1464329 denotes 63
17696610-14718568-85497962 44867-44869 14718568 denotes 22
17696610-11113475-85497963 45482-45484 11113475 denotes 64
17696610-7736663-85497964 45652-45654 7736663 denotes 65
17696610-15260895-85497965 46397-46399 15260895 denotes 66
T45666 4144-4145 10559962 denotes 1
T25685 4144-4145 16339446 denotes 1
T67708 4144-4145 15338235 denotes 1
T85336 4144-4145 9334324 denotes 1
T91986 4378-4379 10973068 denotes 5
T18562 4497-4498 10973068 denotes 5
T55762 4624-4625 16546077 denotes 6
T39663 4624-4625 8893012 denotes 6
T14371 4624-4625 10319812 denotes 6
T38939 4624-4625 10619027 denotes 6
T12288 4624-4625 16179256 denotes 6
T89284 4722-4724 12456752 denotes 11
T92324 4918-4919 16339446 denotes 2
T88899 4920-4922 17174924 denotes 12
T6852 5179-5181 15640358 denotes 13
T86139 5179-5181 12004129 denotes 13
T6109 5179-5181 12077403 denotes 13
T38110 5325-5327 9660953 denotes 16
T47522 5861-5862 10319812 denotes 8
T13369 5996-5997 16339446 denotes 2
T3744 5998-6000 17174924 denotes 12
T37507 6234-6236 17174924 denotes 12
T19826 6859-6861 17174924 denotes 12
T61584 7414-7416 16968779 denotes 17
T34992 14943-14945 15515002 denotes 39
T76483 16282-16283 16339446 denotes 2
T8499 16284-16285 10319812 denotes 8
T59142 17533-17535 15640358 denotes 13
T44728 19871-19873 11242108 denotes 18
T98903 20619-20621 9476899 denotes 19
T53052 21453-21455 16530042 denotes 20
T18220 21456-21458 17446169 denotes 21
T84823 21531-21533 14718568 denotes 22
T48623 21534-21536 16055729 denotes 23
T76001 21690-21692 11950880 denotes 24
T22662 21881-21883 9398850 denotes 25
T4234 22484-22486 15580272 denotes 27
T90628 22484-22486 15589157 denotes 27
T67583 22484-22486 16580996 denotes 27
T9873 23734-23736 14704203 denotes 30
T52650 23737-23739 10101178 denotes 31
T7508 23882-23884 14704203 denotes 30
T88778 23885-23887 12091911 denotes 32
T46660 24872-24874 7781899 denotes 33
T61286 25757-25759 11242108 denotes 18
T89712 25880-25881 16339446 denotes 2
T45258 25975-25977 11106739 denotes 34
T41168 25978-25980 11106738 denotes 35
T50334 26280-26282 11686299 denotes 36
T60577 26922-26924 14668445 denotes 37
T42650 27417-27418 10319812 denotes 8
T75874 27794-27796 9590170 denotes 38
T52656 28217-28219 15515002 denotes 39
T5593 28220-28222 15935783 denotes 40
T19680 28875-28877 15515002 denotes 39
T88762 28878-28880 15935783 denotes 40
T34015 28931-28933 16179256 denotes 10
T8585 28934-28936 17174924 denotes 12
T33359 29082-29083 10319812 denotes 8
T76256 29311-29313 9660953 denotes 16
T86952 30305-30307 15640358 denotes 13
T66431 30308-30310 15928951 denotes 41
T31002 31009-31011 17174924 denotes 12
T20162 31229-31231 15297881 denotes 42
T99422 31350-31351 16339446 denotes 2
T99514 32003-32005 11461701 denotes 43
T99400 32100-32102 11461702 denotes 44
T37763 32103-32105 15066280 denotes 45
T86939 32183-32185 16307920 denotes 46
T49986 32650-32652 9409820 denotes 47
T30486 32653-32655 10228176 denotes 48
T82285 32879-32881 16428451 denotes 49
T96944 33075-33077 11779793 denotes 50
T31293 33226-33228 16179256 denotes 10
T35970 33382-33384 17174924 denotes 12
T91810 34069-34071 16980577 denotes 51
T43287 34311-34313 9927482 denotes 52
T49263 35639-35641 16700071 denotes 53
T95418 35942-35944 7776974 denotes 54
T5715 36356-36358 15120994 denotes 55
T32476 36578-36580 8670802 denotes 56
T49716 37181-37183 12456752 denotes 11
T61174 37184-37186 12782723 denotes 57
T54062 38235-38237 11029058 denotes 58
T11603 38735-38737 17122775 denotes 59
T92230 38987-38988 8893012 denotes 7
T50789 39032-39034 15297881 denotes 42
T28037 43169-43171 16822657 denotes 60
T36828 43229-43231 15129012 denotes 61
T23181 43423-43425 15515002 denotes 39
T9507 43426-43428 14769957 denotes 62
T17464 44361-44363 1464329 denotes 63
T11864 44867-44869 14718568 denotes 22
T84276 45482-45484 11113475 denotes 64
T59977 45652-45654 7736663 denotes 65
T73347 46397-46399 15260895 denotes 66

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T61 0-5 NCBITaxon:10088 denotes Mouse
T62 6-26 GO:0051598 denotes Pachytene Checkpoint
T63 6-28 PR_EXT:P38126 denotes Pachytene Checkpoint 2
T64 30-36 PR_EXT:000016672 denotes Trip13
T65 65-72 _FRAGMENT denotes Meiotic
T66 95-103 GO:0007129 denotes Synapsis
T67 73-86 GO_SO_EXT:sequence_rearrangement_process denotes Recombination
T68 152-161 NCBITaxon:40674 denotes mammalian
T69 162-169 GO:0007126 denotes meiosis
T70 171-201 GO:0007129 denotes homologous chromosome synapsis
T71 182-192 GO_SO_EXT:chromosome denotes chromosome
T72 218-231 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T73 244-254 NCBITaxon:2759 denotes eukaryotes
T74 256-265 NCBITaxon:40674 denotes mammalian
T75 281-292 GO:0000075 denotes checkpoints
T76 298-305 GO:0065007 denotes monitor
T77 358-363 NCBITaxon:10088 denotes mouse
T78 364-372 SO_EXT:0000855 denotes ortholog
T79 374-380 PR_EXT:000016672 denotes Trip13
T80 385-405 GO:0051598 denotes pachytene checkpoint
T81 385-407 PR_EXT:P38126 denotes pachytene checkpoint 2
T82 409-413 PR_EXT:P38126 denotes PCH2
T83 446-454 GO:0007129 denotes synapsis
T84 455-465 GO:0000075 denotes checkpoint
T85 469-493 NCBITaxon:4932 denotes Saccharomyces cerevisiae
T86 498-520 NCBITaxon:6239 denotes Caenorhabditis elegans
T87 552-559 GO:0007126 denotes meiosis
T88 575-581 PR_EXT:000016672 denotes TRIP13
T89 592-596 NCBITaxon:10088 denotes mice
T90 605-617 CL:0000017 denotes spermatocyte
T91 618-623 GO:0016265 denotes death
T92 627-636 GO:0000239 denotes pachynema
T93 649-656 CL:0000023 denotes oocytes
T94 664-669 GO:0007567 denotes birth
T95 675-686 GO_SO_EXT:chromosome denotes chromosomes
T96 690-696 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T97 697-710 CL:0000017 denotes spermatocytes
T98 711-718 GO:0007129 denotes synapse
T99 745-752 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T100 756-769 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T101 795-800 PR_EXT:000013672 denotes RAD51
T102 802-805 PR_EXT:000004759 denotes BLM
T103 811-814 GO:0005662 denotes RPA
T104 822-833 GO_SO_EXT:chromosome denotes chromosomes
T105 853-862 GO:0005712 denotes chiasmata
T106 863-870 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T107 871-875 PR_EXT:000010442 denotes MLH1
T108 880-884 PR_EXT:000010443 denotes MLH3
T109 890-902 CHEBI:44658 denotes okadaic acid
T110 916-922 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T111 923-936 CL:0000017 denotes spermatocytes
T112 959-970 GO:0007132 denotes metaphase I
T113 985-996 GO_SO_EXT:chromosome denotes chromosomes
T114 1005-1011 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T115 1043-1056 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T116 1061-1069 GO:0007129 denotes synapsis
T117 1070-1075 SO_EXT:0000704 denotes genes
T118 1076-1081 PR_EXT:000015553 denotes Spo11
T119 1083-1087 PR_EXT:000031227 denotes Mei1
T120 1089-1093 PR_EXT:000013858 denotes Rec8
T121 1099-1103 PR_EXT:000006536 denotes Dmc1
T122 1125-1131 PR_EXT:000016672 denotes Trip13
T123 1149-1155 PR_EXT:000016672 denotes TRIP13
T124 1170-1188 GO:0033313 denotes meiotic checkpoint
T125 1201-1205 NCBITaxon:10088 denotes mice
T126 1230-1236 PR_EXT:000016672 denotes TRIP13
T127 1255-1270 GO:0042148 denotes strand invasion
T128 1298-1311 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T129 1358-1368 GO:0035825 denotes crossovers
T130 1424-1437 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T131 1464-1473 NCBITaxon:40674 denotes mammalian
T132 1474-1481 GO:0007126 denotes meiosis
T133 1522-1530 GO:0006281 denotes repaired
T134 1531-1534 CHEBI_SO_EXT:DNA denotes DNA
T135 1564-1584 GO:0051598 denotes pachytene checkpoint
T136 1585-1593 GO_EXT:reaction_or_response denotes response
T137 1597-1601 NCBITaxon:10088 denotes mice
T513 2977-2995 GO:0007276 denotes genesis of gametes
T514 2988-2995 CL:0000300 denotes gametes
T515 3026-3032 SO_EXT:0001026 denotes genome
T516 3067-3072 GO:0007567 denotes birth
T517 3127-3137 GO_SO_EXT:chromosome denotes chromosome
T518 3158-3180 GO:0007127 denotes first meiotic division
T519 3193-3204 GO_SO_EXT:chromosome denotes chromosomes
T520 3216-3223 GO:0007129 denotes synapse
T521 3233-3246 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T522 3290-3303 GO_SO_EXT:sequence_rearrangement_process denotes Recombination
T523 3311-3318 GO:0006281 denotes repairs
T524 3319-3325 GO:0006281 denotes repair
T525 3326-3339 SO:0000985 denotes double strand
T526 3340-3346 MOP:0000780 denotes breaks
T527 3363-3374 SO_EXT:0000704 denotes genetically
T528 3386-3395 GO:0000237 denotes leptonema
T529 3413-3421 GO:0007129 denotes synapsis
T530 3425-3432 GO:0007114 denotes budding
T531 3425-3438 NCBITaxon:4892 denotes budding yeast
T532 3443-3450 NCBITaxon:40674 denotes mammals
T533 3502-3515 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T534 3581-3594 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T535 3610-3621 GO_EXT:biological_recruitment denotes recruitment
T536 3625-3628 CHEBI_SO_EXT:DNA denotes DNA
T537 3625-3640 GO:0006260 denotes DNA replication
T538 3658-3673 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T539 3658-3680 GO:0000725 denotes recombinational repair
T540 3719-3725 GO:0006281 denotes repair
T541 3755-3768 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T542 3782-3811 GO:0007129 denotes homologous chromosome pairing
T543 3793-3803 GO_SO_EXT:chromosome denotes chromosome
T544 3821-3829 GO:0006281 denotes repaired
T545 3830-3840 GO_SO_EXT:chromosome denotes chromosome
T546 3841-3847 MOP:0000780 denotes breaks
T547 3859-3869 PATO_SO_EXT:aneuploidy denotes aneuploidy
T548 3884-3897 GO:0035825 denotes crossing over
T549 3935-3947 GO:0065007 denotes surveillance
T550 3958-3969 GO:0000075 denotes checkpoints
T551 3981-3986 GO_EXT:detection_or_sensing_of_stimulus denotes sense
T552 3987-3994 GO:0007126 denotes meiotic
T553 4006-4015 GO_EXT:killing denotes eliminate
T554 4016-4021 CL_GO_EXT:cell denotes cells
T555 4061-4070 NCBITaxon:1 denotes organisms
T556 4082-4095 NCBITaxon:4932 denotes S. cerevisiae
T557 4097-4120 NCBITaxon:7227 denotes Drosophila melanogaster
T558 4122-4132 NCBITaxon:6239 denotes C. elegans
T559 4138-4142 NCBITaxon:10088 denotes mice
T560 4176-4189 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T561 4197-4207 GO_SO_EXT:chromosome denotes chromosome
T562 4197-4216 GO:0007129 denotes chromosome synapsis
T563 4225-4232 GO:0007126 denotes meiotic
T564 4247-4256 GO:0000239 denotes pachytene
T565 4266-4284 GO:0007128 denotes meiotic prophase I
T566 4291-4299 GO_EXT:reaction_or_response denotes response
T567 4303-4310 GO:0007126 denotes meiotic
T568 4342-4362 GO:0051598 denotes pachytene checkpoint
T569 4383-4390 SO_EXT:0000704 denotes Genetic
T570 4406-4419 NCBITaxon:4932 denotes S. cerevisiae
T571 4452-4472 GO:0051598 denotes pachytene checkpoint
T572 4517-4524 GO:0007126 denotes meiosis
T573 4534-4542 CHEBI_PR_EXT:protein denotes proteins
T574 4585-4588 CHEBI_SO_EXT:DNA denotes DNA
T575 4585-4605 GO:0042770 denotes DNA damage signaling
T576 4609-4616 GO:0007067 denotes mitotic
T577 4617-4622 CL_GO_EXT:cell denotes cells
T578 4631-4651 NCBITaxon:3702 denotes Arabidopsis thaliana
T579 4678-4698 GO:0051598 denotes pachytene checkpoint
T580 4715-4720 NCBITaxon_EXT:yeast denotes yeast
T581 4734-4738 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T582 4739-4749 NCBITaxon:7215 denotes Drosophila
T583 4755-4775 GO:0051598 denotes pachytene checkpoint
T584 4788-4795 GO:0065007 denotes monitor
T585 4811-4818 GO:0007126 denotes meiotic
T586 4819-4829 GO_SO_EXT:chromosome denotes chromosome
T587 4830-4840 GO:0008152 denotes metabolism
T588 4844-4857 NCBITaxon:4932 denotes S. cerevisiae
T589 4862-4872 NCBITaxon:6239 denotes C. elegans
T590 4878-4888 GO:0006302 denotes DSB repair
T591 4897-4907 GO_SO_EXT:chromosome denotes chromosome
T592 4897-4916 GO:0007129 denotes chromosome synapsis
T593 4928-4932 NCBITaxon:10088 denotes mice
T594 4939-4952 CL:0000017 denotes spermatocytes
T595 4957-4964 CL:0000023 denotes oocytes
T596 4975-4984 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T597 4998-5008 GO:0006302 denotes DSB repair
T598 5018-5022 PR_EXT:000006536 denotes Dmc1
T599 5024-5028 PR_EXT:000010669 denotes Msh5
T600 5034-5037 PR_EXT:000004427 denotes Atm
T601 5055-5065 GO_EXT:killing denotes eliminated
T602 5069-5078 GO:0000239 denotes pachynema
T603 5084-5097 CL:0000017 denotes spermatocytes
T604 5125-5135 GO:0006302 denotes DSB repair
T605 5148-5156 GO:0007129 denotes synapsis
T606 5170-5177 CL:0000023 denotes oocytes
T607 5204-5217 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T608 5234-5242 GO:0007129 denotes synapsis
T609 5246-5250 NCBITaxon:10088 denotes mice
T610 5252-5261 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T611 5265-5278 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T612 5279-5284 SO_EXT:0000704 denotes genes
T613 5293-5297 PR_EXT:000006536 denotes Dmc1
T614 5315-5323 GO:0007129 denotes synapsis
T615 5394-5414 GO:0051598 denotes pachytene checkpoint
T616 5420-5428 GO_EXT:reaction_or_response denotes responds
T617 5443-5450 GO:0007126 denotes meiotic
T618 5451-5464 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T619 5523-5536 CL:0002371 denotes somatic cells
T620 5531-5536 CL_GO_EXT:cell denotes cells
T621 5565-5585 GO:0051598 denotes pachytene checkpoint
T622 5586-5593 GO:0065007 denotes control
T623 5612-5619 NCBITaxon:40674 denotes mammals
T624 5630-5639 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T625 5678-5682 PR_EXT:P38126 denotes PCH2
T626 5684-5692 SO_EXT:sequence_coding_function denotes encoding
T627 5695-5704 GO:0005730 denotes nucleolar
T628 5705-5714 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T629 5719-5725 GO_EXT:0016887 denotes ATPase
T630 5763-5776 NCBITaxon:4932 denotes S. cerevisiae
T631 5777-5784 SO_EXT:0000704 denotes genetic
T632 5796-5803 SO_EXT:sequence_altered_entity denotes mutants
T633 5817-5826 GO:0000239 denotes pachytene
T634 5838-5846 GO:0007129 denotes synaptic
T635 5847-5851 PR_EXT:P31111 denotes zip1
T636 5852-5859 SO_EXT:sequence_altered_entity denotes mutants
T637 5925-5934 _FRAGMENT denotes pachytene
T638 5965-5975 GO:0051598 denotes checkpoint
T639 5935-5943 GO:0007129 denotes synapsis
T640 5953-5963 GO:0006302 denotes DSB repair
T641 5979-5984 NCBITaxon_EXT:yeast denotes yeast
T642 5989-5994 NCBITaxon_EXT:worm denotes worms
T643 6003-6007 PR_EXT:P38126 denotes PCH2
T644 6008-6017 SO_EXT:0000855 denotes orthologs
T645 6033-6042 NCBITaxon:1 denotes organisms
T646 6056-6064 GO:0007129 denotes synaptic
T647 6065-6072 GO:0007126 denotes meiosis
T648 6083-6091 GO:0007129 denotes synaptic
T649 6092-6099 GO:0007126 denotes meiosis
T650 6133-6137 PR_EXT:P38126 denotes Pch2
T651 6148-6158 GO:0000075 denotes checkpoint
T652 6170-6177 GO:0065007 denotes monitor
T653 6178-6198 GO:0000795 denotes synaptonemal complex
T654 6200-6202 GO:0000795 denotes SC
T655 6217-6222 NCBITaxon_EXT:yeast denotes yeast
T656 6226-6232 NCBITaxon:9606 denotes humans
T657 6258-6262 NCBITaxon:10088 denotes mice
T658 6281-6287 PR_EXT:000016672 denotes Trip13
T659 6293-6301 SO_EXT:0000855 denotes ortholog
T660 6305-6309 PR_EXT:P38126 denotes PCH2
T661 6361-6381 GO:0051598 denotes pachytene checkpoint
T662 6428-6438 GO:0000075 denotes checkpoint
T663 6490-6497 CHEBI_PR_EXT:protein denotes protein
T664 6504-6513 GO:0035825 denotes crossover
T665 6520-6529 _FRAGMENT denotes repair of
T666 6538-6542 GO:0006302 denotes DSBs
T667 6530-6537 GO:0007126 denotes meiotic
T1363 6573-6582 GO:0010467 denotes Expressed
T1364 6583-6592 NCBITaxon:40674 denotes Mammalian
T1365 6593-6601 SO_EXT:0000855 denotes Ortholog
T1366 6605-6609 PR_EXT:P38126 denotes PCH2
T1367 6654-6663 NCBITaxon:40674 denotes mammalian
T1368 6664-6672 SO_EXT:0000855 denotes ortholog
T1369 6676-6680 PR_EXT:P38126 denotes PCH2
T1370 6682-6688 PR_EXT:000016672 denotes Trip13
T1371 6690-6697 UBERON:0002046 denotes thyroid
T1372 6690-6705 CHEBI_EXT:60311 denotes thyroid hormone
T1373 6690-6714 GO_EXT:0004887 denotes thyroid hormone receptor
T1374 6690-6737 PR_EXT:000016672 denotes thyroid hormone receptor interacting protein 13
T1375 6727-6734 CHEBI_PR_EXT:protein denotes protein
T1376 6740-6747 SO_EXT:sequence_coding_function denotes encodes
T1377 6750-6757 CHEBI_PR_EXT:protein denotes protein
T1378 6773-6783 CHEBI_SO_EXT:amino_acid denotes amino acid
T1379 6784-6792 SO:0000857 denotes homology
T1380 6821-6826 NCBITaxon_EXT:yeast denotes yeast
T1381 6831-6835 NCBITaxon_EXT:worm denotes worm
T1382 6836-6845 SO_EXT:0000855 denotes orthologs
T1383 6905-6911 PR_EXT:000016672 denotes TRIP13
T1384 6933-6942 NCBITaxon:40674 denotes mammalian
T1385 6943-6950 CHEBI_PR_EXT:protein denotes protein
T1386 6976-6982 NCBITaxon:3193 denotes plants
T1387 7003-7017 _FRAGMENT denotes evolutionarily
T1388 7031-7038 SO:0000857 denotes related
T1389 7039-7044 NCBITaxon_EXT:worm denotes worms
T1390 7049-7054 NCBITaxon:7147 denotes flies
T1391 7102-7123 GO_EXT:0003964 denotes reverse-transcriptase
T1392 7129-7131 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T1393 7153-7159 PR_EXT:000016672 denotes Trip13
T1394 7160-7164 CHEBI_SO_EXT:mRNA denotes mRNA
T1395 7171-7180 GO:0010467 denotes expressed
T1396 7197-7206 _FRAGMENT denotes embryonic
T1397 7217-7224 UBERON:0005291 denotes tissues
T1398 7211-7216 UBERON:0007023 denotes adult
T1399 7236-7242 UBERON:0000473 denotes testis
T1400 7272-7277 NCBITaxon:10088 denotes mouse
T1401 7282-7287 NCBITaxon:9606 denotes human
T1402 7288-7291 SO_EXT:0000345 denotes EST
T1403 7376-7385 GO:0010467 denotes expressed
T1404 7389-7394 NCBITaxon:9606 denotes human
T1405 7399-7404 NCBITaxon:10088 denotes mouse
T1406 7405-7412 CL:0000023 denotes oocytes
T1661 11374-11380 GO:0008380 denotes splice
T1662 11374-11389 SO_EXT:splice_acceptor denotes splice acceptor
T1663 11433-11441 GO:0042571 denotes antibody
T1664 11459-11466 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T1665 11467-11474 SO_EXT:sequence_coding_function denotes encoded
T1666 11478-11482 SO_EXT:0000147 denotes exon
T1667 11515-11524 SO_EXT:wild_type_entity_or_quality denotes wild-type
T1668 11542-11548 UBERON:0000473 denotes testes
T1669 11680-11686 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1670 11687-11693 UBERON:0000473 denotes testes
T1671 11803-11809 PR_EXT:000016672 denotes TRIP13
T1672 11833-11839 PR_EXT:000016672 denotes Trip13
T1673 11840-11844 CHEBI_SO_EXT:mRNA denotes mRNA
T1674 11874-11881 CHEBI_PR_EXT:protein denotes protein
T1675 11885-11892 SO_EXT:sequence_altered_entity denotes mutants
T1676 11911-11917 PR_EXT:000016672 denotes Trip13
T1677 11924-11930 SO_EXT:0001023 denotes allele
T1678 11973-11982 CL:0000586 denotes germ cell
T1679 11978-11982 CL_GO_EXT:cell denotes cell
T1680 11998-12004 PR_EXT:000016672 denotes TRIP13
T1681 12008-12017 GO:0010467 denotes expressed
T1682 12042-12052 GO:0010467 denotes expression
T1683 12060-12066 SO_EXT:sequence_altered_entity denotes mutant
T1684 12105-12111 UBERON:0000473 denotes testis
T1685 12144-12150 PR_EXT:000016672 denotes TRIP13
T1686 12170-12177 NCBITaxon:9031 denotes chicken
T1687 12182-12189 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T1688 12190-12198 GO:0042571 denotes antibody
T1689 12247-12254 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeled
T1690 12255-12260 CL_GO_EXT:cell denotes cells
T1691 12272-12278 UBERON:0000473 denotes testes
T1692 12291-12304 CL:0000020 denotes spermatogonia
T1693 12309-12318 GO:0000237 denotes leptotene
T1694 12319-12332 CL:0000017 denotes spermatocytes
T1695 12346-12354 GO:0000238 denotes Zygotene
T1696 12355-12364 GO:0000239 denotes pachytene
T1697 12365-12378 CL:0000017 denotes spermatocytes
T1698 12447-12456 GO:0000239 denotes pachytene
T1699 12457-12470 CL:0000017 denotes spermatocytes
T1700 12472-12478 PR_EXT:000016672 denotes TRIP13
T1701 12494-12501 GO:0005634 denotes nuclear
T1702 12502-12511 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T1703 12543-12549 GO:0005634 denotes nuclei
T1704 12553-12559 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1705 12560-12580 UBERON:0001343 denotes seminiferous tubules
T1706 12616-12623 GO:0005634 denotes nuclear
T1707 12624-12636 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T1708 12638-12644 PR_EXT:000016672 denotes TRIP13
T1709 12663-12670 GO:0007126 denotes meiotic
T1710 12671-12682 GO_SO_EXT:chromosome denotes chromosomes
T1711 12716-12728 CL:0000017 denotes spermatocyte
T1712 12729-12735 GO:0005634 denotes nuclei
T1713 12740-12749 SO_EXT:wild_type_entity_or_quality denotes wild type
T1714 12769-12776 GO:0005634 denotes nuclear
T1715 12823-12825 GO:0000795 denotes SC
T1716 12833-12839 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes marked
T1717 12847-12860 GO:0000800 denotes axial element
T1718 12861-12868 CHEBI_PR_EXT:protein denotes protein
T1719 12869-12874 PR_EXT:000015865 denotes SYCP3
T1720 12883-12899 GO:0098762 denotes meiotic substage
T1721 12913-12919 PR_EXT:000016672 denotes TRIP13
T1722 12952-12958 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1723 12959-12966 GO:0007126 denotes meiotic
T1724 12967-12973 GO:0005634 denotes nuclei
T2297 16212-16220 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T2298 16224-16228 PR_EXT:P38126 denotes Pch2
T2299 16256-16261 CL:0002369 denotes spore
T2300 16256-16261 _FRAGMENT denotes spore
T2301 16269-16280 GO:0030435 denotes development
T2302 16262-16268 CL:0000300 denotes gamete
T2303 16262-16280 GO:0007276 denotes gamete development
T2741 16289-16295 PR_EXT:000016672 denotes TRIP13
T2742 16324-16354 GO:0007129 denotes Homologous Chromosome Synapsis
T2743 16335-16345 GO_SO_EXT:chromosome denotes Chromosome
T2744 16381-16389 GO:0006281 denotes repaired
T2745 16398-16407 GO:0000239 denotes Pachynema
T2746 16445-16452 GO:0007126 denotes meiotic
T2747 16468-16474 PR_EXT:000016672 denotes Trip13
T2748 16480-16493 CL:0000017 denotes spermatocytes
T2749 16512-16522 GO_SO_EXT:chromosome denotes chromosome
T2750 16535-16540 PR_EXT:000015865 denotes SYCP3
T2751 16545-16550 PR_EXT:000015862 denotes SYCP1
T2752 16570-16575 _FRAGMENT denotes axial
T2753 16584-16592 GO:0000800 denotes elements
T2754 16576-16592 GO:0000800 denotes lateral elements
T2755 16597-16617 GO:0000802 denotes transverse filaments
T2756 16640-16660 GO:0000795 denotes synaptonemal complex
T2757 16662-16664 GO:0000795 denotes SC
T2758 16667-16676 GO:0000239 denotes Pachytene
T2759 16677-16689 CL:0000017 denotes spermatocyte
T2760 16690-16696 GO:0005634 denotes nuclei
T2761 16715-16721 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2762 16722-16728 UBERON:0000473 denotes testes
T2763 16751-16753 GO:0000795 denotes SC
T2764 16779-16802 GO:0007129 denotes synapsis of chromosomes
T2765 16791-16802 GO_SO_EXT:chromosome denotes chromosomes
T2766 16818-16826 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeling
T2767 16830-16835 PR_EXT:000015862 denotes SYCP1
T2827 20078-20082 PR_EXT:000006536 denotes DMC1
T2828 20101-20116 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T2829 20101-20123 GO:0000725 denotes recombinational repair
T2830 20117-20131 GO:0006302 denotes repair of DSBs
T2831 20150-20165 GO:0008278 denotes cohesin complex
T2832 20223-20231 GO:0007129 denotes synaptic
T2833 20312-20319 GO:0007126 denotes meiosis
T2834 20338-20343 PR_EXT:000015706 denotes STAG3
T2835 20369-20373 PR_EXT:000013858 denotes REC8
T2836 20402-20407 NCBITaxon_EXT:yeast denotes yeast
T2837 20408-20412 PR_EXT:P38126 denotes PCH2
T2838 20413-20422 GO_PATO_EXT:biological_localization_process_or_quality denotes localizes
T2839 20426-20435 GO_SO_EXT:telomere_or_telomeric_region_or_telomeric_orientation denotes telomeres
T2840 20488-20496 GO_SO_EXT:telomere_or_telomeric_region_or_telomeric_orientation denotes telomere
T2841 20527-20531 PR_EXT:000016236 denotes TRF2
T2842 20550-20557 CHEBI_PR_EXT:protein denotes protein
T2843 20550-20565 GO:0043234 denotes protein complex
T2844 20598-20606 GO_SO_EXT:telomere_or_telomeric_region_or_telomeric_orientation denotes telomere
T2845 20631-20640 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T2846 20644-20653 GO_SO_EXT:telomere_or_telomeric_region_or_telomeric_orientation denotes telomeres
T2847 20668-20676 GO:0007129 denotes synapsed
T2848 20681-20694 GO_SO_EXT:telomere_or_telomeric_region_or_telomeric_orientation denotes telomerically
T2849 20696-20704 GO:0007129 denotes synaptic
T2850 20705-20711 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2851 20712-20723 GO_SO_EXT:chromosome denotes chromosomes
T2852 20757-20767 GO:0006302 denotes DSB repair
T2853 20787-20796 GO:0000239 denotes pachynema
T2854 20813-20819 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2855 20820-20832 CL:0000017 denotes spermatocyte
T2856 20833-20839 GO:0005634 denotes nuclei
T2857 20845-20855 GO:0042571 denotes antibodies
T2858 20864-20873 CHEBI:36357 denotes molecules
T2859 20904-20917 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T2860 20930-20936 PR_EXT:000016672 denotes Trip13
T2861 20942-20952 GO_SO_EXT:chromosome denotes chromosome
T2862 20962-20965 PR_EXT:000004759 denotes BLM
T2863 20966-20974 GO_EXT:0004386 denotes helicase
T2864 20995-21000 PR_EXT:000013672 denotes RAD51
T2865 21001-21005 PR_EXT:000006536 denotes DMC1
T2866 21056-21062 PR_EXT:000016548 denotes TOPBP1
T2867 21110-21118 GO:0007129 denotes synapsed
T2868 21119-21130 GO_SO_EXT:chromosome denotes chromosomes
T2869 21136-21141 PR_EXT:000013672 denotes RAD51
T2870 21142-21146 PR_EXT:000006536 denotes DMC1
T2871 21148-21154 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2872 21155-21164 GO:0000239 denotes pachytene
T2873 21165-21178 CL:0000017 denotes spermatocytes
T2874 21230-21239 SO_EXT:wild_type_entity_or_quality denotes wild type
T2875 21267-21274 GO:0001741 denotes XY body
T2876 21299-21307 GO:0000238 denotes zygonema
T2877 21338-21347 SO_EXT:wild_type_entity_or_quality denotes wild type
T2878 21350-21356 PR_EXT:000016548 denotes TOPBP1
T2879 21362-21365 CHEBI_SO_EXT:DNA denotes DNA
T2880 21362-21383 GO:0000077 denotes DNA damage–checkpoint
T2881 21384-21391 CHEBI_PR_EXT:protein denotes protein
T2882 21404-21407 PR_EXT:000004427 denotes ATM
T2883 21408-21415 CHEBI_PR_EXT:protein denotes protein
T2884 21440-21443 PR_EXT:000004499 denotes ATR
T2885 21444-21451 CHEBI_PR_EXT:protein denotes protein
T2886 21464-21469 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T2887 21490-21498 GO:0007129 denotes synapsed
T2888 21499-21509 _FRAGMENT denotes regions of
T2889 21518-21529 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosomes
T2890 21510-21517 GO:0007126 denotes meiotic
T2891 21539-21542 PR_EXT:000004759 denotes BLM
T2892 21566-21574 GO_PATO_EXT:biological_localization_process_or_quality denotes localize
T2893 21580-21587 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T2894 21589-21592 GO:0005662 denotes RPA
T2895 21597-21601 PR_EXT:000010668 denotes MSH4
T2896 21606-21619 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T2897 21673-21683 GO:0035825 denotes crossovers
T2898 21685-21687 GO:0035825 denotes CO
T2899 21737-21740 GO:0005662 denotes RPA
T2900 21746-21751 CHEBI_SO_EXT:single_stranded_DNA denotes ssDNA
T2901 21752-21759 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T2902 21760-21767 CHEBI_PR_EXT:protein denotes protein
T2903 21813-21822 GO:0007129 denotes synapsing
T2904 21823-21830 GO:0007126 denotes meiotic
T2905 21831-21842 GO_SO_EXT:chromosome denotes chromosomes
T2906 21870-21879 GO:0000239 denotes pachynema
T2907 21903-21907 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T2908 21908-21915 SO_EXT:0000297 denotes D-loops
T2909 21919-21932 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T2910 21953-21956 GO:0005662 denotes RPA
T2911 21975-21984 GO:0000239 denotes pachytene
T2912 21985-21991 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2913 21992-22003 GO_SO_EXT:chromosome denotes chromosomes
T2914 22051-22059 GO:0006281 denotes repaired
T2915 22080-22093 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T2916 22119-22128 GO:0000239 denotes pachynema
T2917 22144-22147 CHEBI_SO_EXT:DNA denotes DNA
T2918 22144-22165 GO:0000077 denotes DNA damage checkpoint
T2919 22198-22209 GO_SO_EXT:chromosome denotes chromosomes
T2920 22222-22229 GO:0007126 denotes meiotic
T2921 22230-22244 GO:0000803 denotes sex chromosome
T2922 22234-22244 GO_SO_EXT:chromosome denotes chromosome
T2923 22269-22276 GO:0007126 denotes meiotic
T2924 22277-22289 _FRAGMENT denotes silencing of
T2925 22299-22308 GO:0006342 denotes chromatin
T2926 22292-22298 GO:0007129 denotes paired
T2927 22299-22308 GO:0000785 denotes chromatin
T2928 22339-22349 GO:0042571 denotes antibodies
T2929 22362-22372 GO:0006302 denotes DSB repair
T2930 22384-22393 CHEBI:36357 denotes molecules
T2931 22412-22416 PR_EXT:000008418 denotes H2AX
T2932 22417-22432 GO_PATO_EXT:phosphorylation_process denotes phosphorylation
T2933 22470-22473 PR_EXT:000004499 denotes ATR
T2934 22479-22482 PR_EXT:000004427 denotes ATM
T2935 22498-22504 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2936 22505-22516 GO_SO_EXT:chromosome denotes chromosomes
T2937 22527-22535 GO:0007129 denotes synapsed
T2938 22585-22593 GO:0007129 denotes synapsis
T2939 22613-22619 PR_EXT:000016672 denotes Trip13
T2940 22625-22636 GO_SO_EXT:chromosome denotes chromosomes
T2941 22642-22645 CHEBI_SO_EXT:DNA denotes DNA
T2942 22642-22652 GO:0006281 denotes DNA repair
T2943 22653-22660 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T2944 22700-22703 CHEBI_SO_EXT:DNA denotes DNA
T2945 22700-22710 GO:0006281 denotes DNA repair
T2946 22723-22748 GO:0006342 denotes transcriptional silencing
T2947 22793-22799 PR_EXT:000016672 denotes Trip13
T2948 22805-22814 GO:0000239 denotes pachytene
T2949 22815-22828 CL:0000017 denotes spermatocytes
T2950 22850-22853 CHEBI_SO_EXT:DNA denotes DNA
T2951 22850-22860 GO:0006281 denotes DNA repair
T2952 22861-22868 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T2953 22874-22880 UBERON:0000473 denotes testis
T2954 22918-22925 GO:0007126 denotes meiotic
T2955 22968-22977 GO:0000240 denotes diplotene
T2956 22978-22984 GO:0005634 denotes nuclei
T2957 22997-23006 GO:0030849 denotes autosomal
T2958 23007-23012 PR_EXT:000013672 denotes RAD51
T2959 23013-23017 PR_EXT:000006536 denotes DMC1
T2960 23055-23066 GO:0007132 denotes metaphase I
T2961 23117-23123 PR_EXT:000016672 denotes Trip13
T2962 23148-23152 SO_EXT:null_sequence_entity denotes null
T2963 23160-23169 GO:0000240 denotes diplotene
T2964 23174-23185 GO:0007132 denotes metaphase I
T2965 23186-23199 CL:0000017 denotes spermatocytes
T2966 23243-23252 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2967 23253-23259 PR_EXT:000016672 denotes TRIP13
T4037 23262-23264 GO:0035825 denotes CO
T4038 23276-23283 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes Markers
T4039 23318-23324 PR_EXT:000016672 denotes TRIP13
T4040 23344-23347 PR_EXT:000004759 denotes BLM
T4041 23351-23357 PR_EXT:000016672 denotes Trip13
T4042 23363-23375 CL:0000017 denotes spermatocyte
T4043 23376-23387 GO_SO_EXT:chromosome denotes chromosomes
T4044 23429-23437 GO:0006281 denotes repaired
T4045 23480-23495 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T4046 23480-23502 GO:0000725 denotes recombinational repair
T4047 23522-23538 GO:0035825 denotes CO recombination
T4048 23525-23538 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T4049 23553-23559 SO_EXT:sequence_altered_entity denotes mutant
T4050 23597-23612 GO:0006298 denotes mismatch repair
T4051 23613-23621 CHEBI_PR_EXT:protein denotes proteins
T4052 23622-23626 PR_EXT:000010442 denotes MLH1
T4053 23631-23635 PR_EXT:000010443 denotes MLH3
T4054 23687-23696 GO:0000239 denotes pachynema
T4055 23701-23705 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes mark
T4056 23723-23732 GO:0005712 denotes chiasmata
T4057 23754-23758 PR_EXT:000010442 denotes MLH1
T4058 23800-23810 GO_SO_EXT:chromosome denotes chromosome
T4059 23817-23826 SO_EXT:wild_type_entity_or_quality denotes wild type
T4060 23858-23862 PR_EXT:000010443 denotes MLH3
T4061 23902-23911 GO:0000239 denotes pachytene
T4062 23912-23923 GO_SO_EXT:chromosome denotes chromosomes
T4063 23943-23947 PR_EXT:000010442 denotes MLH1
T4064 23973-23979 PR_EXT:000016672 denotes Trip13
T4065 23985-23994 GO:0000239 denotes pachytene
T4066 23995-24001 GO:0005634 denotes nuclei
T4067 24013-24019 GO:0006281 denotes repair
T4068 24056-24066 GO:0006302 denotes DSB repair
T4069 24067-24074 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4070 24104-24113 GO:0000239 denotes pachytene
T4071 24114-24120 GO:0005634 denotes nuclei
T4072 24125-24129 PR_EXT:000010442 denotes MLH1
T4073 24163-24167 PR_EXT:000010442 denotes MLH1
T4074 24190-24201 GO_SO_EXT:chromosome denotes chromosomes
T4075 24213-24221 GO:0006281 denotes repaired
T4076 24284-24288 PR_EXT:000010442 denotes MLH1
T4077 24293-24298 PR_EXT:000013672 denotes RAD51
T4078 24299-24303 PR_EXT:000006536 denotes DMC1
T4079 24305-24309 PR_EXT:000010442 denotes MLH1
T4080 24331-24342 GO_SO_EXT:chromosome denotes chromosomes
T4081 24372-24377 PR_EXT:000013672 denotes RAD51
T4082 24378-24382 PR_EXT:000006536 denotes DMC1
T4083 24432-24436 PR_EXT:000010442 denotes MLH1
T4084 24447-24453 PR_EXT:000016672 denotes Trip13
T4085 24459-24468 GO:0000239 denotes pachytene
T4086 24469-24482 CL:0000017 denotes spermatocytes
T4087 24493-24495 GO:0035825 denotes CO
T4088 24593-24603 GO:0007128 denotes prophase I
T4089 24616-24626 UBERON:0000473 denotes testicular
T4090 24627-24632 CL_GO_EXT:cell denotes cells
T4091 24663-24664 SO_EXT:normal_or_wild_type_or_present denotes +
T4092 24665-24666 SO_EXT:normal_or_wild_type_or_present denotes +
T4093 24669-24675 PR_EXT:000016672 denotes Trip13
T4094 24686-24690 PR_EXT:000006536 denotes Dmc1
T4095 24691-24692 SO_EXT:sequence_nullness_or_absence denotes −
T4096 24693-24694 SO_EXT:sequence_nullness_or_absence denotes −
T4097 24695-24699 NCBITaxon:10088 denotes mice
T4098 24709-24716 CHEBI_PR_EXT:protein denotes protein
T4099 24709-24738 CHEBI_GO_EXT:phosphoprotein_phosphatase_inhibitor denotes protein phosphatase inhibitor
T4100 24729-24738 CHEBI_EXT:35222 denotes inhibitor
T4101 24739-24751 CHEBI:44658 denotes okadaic acid
T4102 24753-24755 CHEBI:44658 denotes OA
T4103 24760-24768 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes chemical
T4104 24782-24796 _FRAGMENT denotes degradation of
T4105 24801-24803 GO:0070194 denotes SC
T4106 24801-24803 GO:0000795 denotes SC
T4107 24805-24815 GO_SO_EXT:chromosome denotes chromosome
T4108 24805-24828 GO:0030261 denotes chromosome condensation
T4109 24859-24870 GO:0007132 denotes metaphase I
T4110 24885-24894 GO:0051323 denotes metaphase
T4111 24928-24936 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T4112 24957-24961 PR_EXT:000006536 denotes Dmc1
T4113 24962-24963 SO_EXT:sequence_nullness_or_absence denotes −
T4114 24964-24965 SO_EXT:sequence_nullness_or_absence denotes −
T4115 24990-25011 GO:0000793 denotes condensed chromosomes
T4116 25000-25011 GO_SO_EXT:chromosome denotes chromosomes
T4117 25024-25025 SO_EXT:normal_or_wild_type_or_present denotes +
T4118 25026-25027 SO_EXT:normal_or_wild_type_or_present denotes +
T4119 25032-25038 PR_EXT:000016672 denotes Trip13
T4120 25083-25087 PR_EXT:000010442 denotes MLH1
T4121 25098-25104 PR_EXT:000016672 denotes Trip13
T4122 25110-25119 GO:0000239 denotes pachytene
T4123 25120-25133 CL:0000017 denotes spermatocytes
T4124 25183-25186 GO:0035825 denotes COs
T4125 25234-25240 UBERON:0000473 denotes testes
T4126 25287-25297 GO:0051323 denotes metaphases
T4127 25303-25307 PR_EXT:000006536 denotes Dmc1
T4128 25308-25309 SO_EXT:sequence_nullness_or_absence denotes −
T4129 25310-25311 SO_EXT:sequence_nullness_or_absence denotes −
T4130 25312-25316 NCBITaxon:10088 denotes mice
T4131 25327-25340 CL:0000020 denotes spermatogonia
T4132 25346-25359 CL:0000017 denotes spermatocytes
T4719 25362-25368 PR_EXT:000016672 denotes TRIP13
T4720 25399-25406 GO:0007126 denotes Meiotic
T4721 25428-25435 SO_EXT:sequence_altered_entity denotes Mutants
T4722 25449-25457 GO:0007129 denotes Synapsis
T4723 25474-25480 PR_EXT:000016672 denotes TRIP13
T4724 25501-25510 GO:0006915 denotes apoptosis
T4725 25525-25533 GO:0007129 denotes synapsis
T4726 25540-25550 NCBITaxon:6239 denotes C. elegans
T4727 25564-25568 NCBITaxon:10088 denotes mice
T4728 25586-25592 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4729 25597-25602 PR_EXT:000015553 denotes Spo11
T4730 25607-25613 PR_EXT:000016672 denotes Trip13
T4731 25615-25620 PR_EXT:000015553 denotes SPO11
T4732 25678-25689 SO_EXT:0000704 denotes genetically
T4733 25712-25721 GO:0000237 denotes leptonema
T4734 25730-25739 NCBITaxon:1 denotes organisms
T4735 25751-25755 NCBITaxon:10088 denotes mice
T4736 25765-25775 NCBITaxon:6239 denotes C. elegans
T4737 25777-25783 PR_EXT:Q22236 denotes spo-11
T4738 25784-25790 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4739 25791-25798 CL:0000300 denotes gametes
T4740 25815-25823 GO:0007129 denotes synapsis
T4741 25840-25845 PR_EXT:P38126 denotes PCH-2
T4742 25856-25865 GO:0006915 denotes apoptosis
T4743 25869-25878 GO:0000239 denotes pachynema
T4744 25887-25891 NCBITaxon:10088 denotes mice
T4745 25893-25898 PR_EXT:000015553 denotes Spo11
T4746 25899-25900 SO_EXT:sequence_nullness_or_absence denotes −
T4747 25901-25902 SO_EXT:sequence_nullness_or_absence denotes −
T4748 25903-25916 CL:0000017 denotes spermatocytes
T4749 25943-25973 GO:0007129 denotes homologous chromosome synapsis
T4750 25954-25964 GO_SO_EXT:chromosome denotes chromosome
T4751 25999-26010 GO_SO_EXT:chromosome denotes chromosomes
T4752 26044-26052 GO:0000238 denotes zygotene
T4753 26053-26062 GO:0000239 denotes pachytene
T4754 26087-26100 CL:0000017 denotes Spermatocytes
T4755 26104-26110 PR_EXT:000016672 denotes Trip13
T4756 26116-26121 PR_EXT:000015553 denotes Spo11
T4757 26122-26123 SO_EXT:sequence_nullness_or_absence denotes −
T4758 26124-26125 SO_EXT:sequence_nullness_or_absence denotes −
T4759 26126-26132 UBERON:0000473 denotes testes
T4760 26186-26191 GO:0016265 denotes death
T4761 26219-26226 GO:0005819 denotes spindle
T4762 26219-26237 GO:0031577 denotes spindle checkpoint
T4763 26243-26253 GO_EXT:killing denotes eliminates
T4764 26255-26264 GO:0005712 denotes chiasmate
T4765 26265-26278 CL:0000017 denotes spermatocytes
T4766 26310-26321 GO:0007132 denotes metaphase I
T4767 26322-26335 CL:0000017 denotes spermatocytes
T4768 26343-26350 GO:0007126 denotes meiotic
T4769 26351-26361 CL:0000018 denotes spermatids
T4770 26371-26377 UBERON:0000473 denotes testes
T4771 26400-26406 PR_EXT:000016672 denotes Trip13
T4772 26414-26421 SO_EXT:sequence_altered_entity denotes mutants
T4773 26463-26471 GO:0007129 denotes synapsis
T4774 26475-26481 PR_EXT:000016672 denotes Trip13
T4775 26487-26496 GO:0000239 denotes pachytene
T4776 26497-26510 CL:0000017 denotes spermatocytes
T4777 26533-26538 PR_EXT:000015553 denotes SPO11
T4778 26555-26564 GO:0000237 denotes leptonema
T4779 26619-26632 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T4780 26656-26666 GO_SO_EXT:chromosome denotes chromosome
T4781 26656-26675 GO:0007129 denotes chromosome synapsis
T4782 26686-26692 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4783 26693-26706 CL:0000017 denotes spermatocytes
T4792 27321-27322 GO_SO_EXT:chromosome denotes s
T4793 27337-27341 PR_EXT:P38126 denotes PCH2
T4794 27357-27366 GO:0000239 denotes pachytene
T4795 27385-27393 GO:0007129 denotes synaptic
T4796 27394-27401 SO_EXT:sequence_altered_entity denotes mutants
T4797 27402-27406 PR_EXT:P31111 denotes zip1
T4798 27411-27415 PR_EXT:P53061 denotes zip2
T4799 27430-27435 NCBITaxon:10088 denotes mouse
T4800 27436-27441 PR_EXT:000015862 denotes SYCP1
T4801 27493-27498 PR_EXT:000015862 denotes Sycp1
T4802 27499-27505 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4803 27506-27519 CL:0000017 denotes spermatocytes
T4804 27562-27568 PR_EXT:000016672 denotes Trip13
T4805 27569-27576 SO_EXT:sequence_altered_entity denotes mutants
T4806 27629-27634 PR_EXT:000015862 denotes Sycp1
T4807 27635-27636 SO_EXT:sequence_nullness_or_absence denotes −
T4808 27637-27638 SO_EXT:sequence_nullness_or_absence denotes −
T4809 27703-27707 PR_EXT:P31111 denotes zip1
T4810 27708-27715 SO_EXT:sequence_altered_entity denotes mutants
T4811 27773-27783 GO_SO_EXT:chromosome denotes chromosome
T4812 27773-27792 GO:0007129 denotes chromosome synapsis
T4813 27848-27853 NCBITaxon_EXT:yeast denotes yeast
T4814 27861-27869 GO_EXT:reaction_or_response denotes responds
T4815 27873-27881 GO:0007129 denotes synapsis
T4816 27882-27896 MOP:0000629 denotes polymerization
T4817 27974-27978 PR_EXT:000013858 denotes Rec8
T4818 27979-27985 SO_EXT:0001023 denotes allele
T4819 27987-27991 PR_EXT:000013858 denotes Rec8
T4820 28012-28016 PR_EXT:000013858 denotes Rec8
T4821 28021-28028 GO:0007126 denotes Meiotic
T4822 28029-28040 GO_SO_EXT:chromosome denotes chromosomes
T4823 28044-28048 PR_EXT:000013858 denotes Rec8
T4824 28049-28055 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4825 28056-28069 CL:0000017 denotes spermatocytes
T4826 28107-28128 GO:0007129 denotes interhomolog synaptic
T4827 28162-28172 GO:0006302 denotes DSB repair
T4828 28194-28215 GO:0007129 denotes interhomolog synapsis
T4829 28261-28268 GO:0007129 denotes synapse
T4830 28277-28282 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bound
T4831 28286-28291 PR_EXT:000015862 denotes SYCP1
T4832 28310-28314 PR_EXT:000013858 denotes Rec8
T4833 28315-28322 SO_EXT:sequence_altered_entity denotes mutants
T4834 28342-28351 GO:0000240 denotes diplonema
T4835 28355-28366 GO:0007132 denotes metaphase I
T4836 28375-28381 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4837 28406-28410 PR_EXT:000013858 denotes Rec8
T4838 28427-28433 PR_EXT:000016672 denotes Trip13
T4839 28445-28450 PR_EXT:000015553 denotes Spo11
T4840 28455-28459 PR_EXT:000031227 denotes Mei1
T4841 28486-28492 UBERON:0000473 denotes testes
T4842 28512-28516 PR_EXT:000013858 denotes REC8
T4843 28521-28527 PR_EXT:000016672 denotes TRIP13
T4844 28542-28546 PR_EXT:000013858 denotes Rec8
T4845 28547-28553 SO_EXT:sequence_altered_entity denotes mutant
T4846 28590-28601 GO:0007132 denotes metaphase I
T4847 28617-28623 PR_EXT:000016672 denotes Trip13
T4848 28629-28633 NCBITaxon:10088 denotes mice
T4849 28691-28702 GO_SO_EXT:chromosome denotes chromosomes
T4850 28723-28753 GO:0007129 denotes homologous chromosome synapsis
T4851 28734-28744 GO_SO_EXT:chromosome denotes chromosome
T4852 28766-28770 PR_EXT:000013858 denotes Rec8
T4853 28771-28772 SO_EXT:sequence_nullness_or_absence denotes −
T4854 28773-28774 SO_EXT:sequence_nullness_or_absence denotes −
T4855 28779-28783 PR_EXT:000013858 denotes Rec8
T4856 28784-28785 SO_EXT:sequence_nullness_or_absence denotes −
T4857 28786-28787 SO_EXT:sequence_nullness_or_absence denotes −
T4858 28788-28794 PR_EXT:000016672 denotes Trip13
T4859 28800-28813 CL:0000017 denotes spermatocytes
T4860 28842-28846 PR_EXT:000013858 denotes Rec8
T4861 28847-28854 SO_EXT:sequence_altered_entity denotes mutants
T4862 28939-28947 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T4863 28951-28955 PR_EXT:P38126 denotes PCH2
T4864 28959-28964 NCBITaxon_EXT:yeast denotes yeast
T4865 29002-29009 GO:0007126 denotes meiotic
T4866 29046-29053 GO:0007126 denotes meiosis
T4867 29063-29067 PR_EXT:000023696 denotes RecA
T4868 29068-29075 SO_EXT:0000853 denotes homolog
T4869 29076-29080 PR_EXT:000006536 denotes DMC1
T4870 29122-29126 NCBITaxon:10088 denotes mice
T4871 29143-29150 NCBITaxon:33208 denotes animals
T4872 29158-29164 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4873 29169-29175 PR_EXT:000016672 denotes Trip13
T4874 29180-29184 PR_EXT:000006536 denotes Dmc1
T4875 29192-29196 PR_EXT:000006536 denotes Dmc1
T4876 29197-29198 SO_EXT:sequence_nullness_or_absence denotes −
T4877 29199-29200 SO_EXT:sequence_nullness_or_absence denotes −
T4878 29201-29205 NCBITaxon:10088 denotes mice
T4879 29216-29229 CL:0000017 denotes spermatocytes
T4880 29238-29245 GO:0007126 denotes meiotic
T4881 29268-29278 GO:0006302 denotes DSB repair
T4882 29290-29300 GO_SO_EXT:chromosome denotes chromosome
T4883 29290-29309 GO:0007129 denotes chromosome synapsis
T4884 29316-29331 GO:0007283 denotes spermatogenesis
T4885 29335-29339 PR_EXT:000006536 denotes Dmc1
T4886 29340-29341 SO_EXT:sequence_nullness_or_absence denotes −
T4887 29342-29343 SO_EXT:sequence_nullness_or_absence denotes −
T4888 29344-29350 PR_EXT:000016672 denotes Trip13
T4889 29356-29362 UBERON:0000473 denotes testes
T4890 29405-29418 CL:0000017 denotes spermatocytes
T4891 29429-29438 GO:0000785 denotes chromatin
T4892 29457-29465 GO:0000238 denotes zygonema
T4893 29466-29475 GO:0000239 denotes pachynema
T4894 29536-29540 PR_EXT:000006536 denotes Dmc1
T4895 29541-29542 SO_EXT:sequence_nullness_or_absence denotes −
T4896 29543-29544 SO_EXT:sequence_nullness_or_absence denotes −
T4897 29549-29553 PR_EXT:000006536 denotes Dmc1
T4898 29554-29555 SO_EXT:sequence_nullness_or_absence denotes −
T4899 29556-29557 SO_EXT:sequence_nullness_or_absence denotes −
T4900 29558-29564 PR_EXT:000016672 denotes Trip13
T4901 29570-29581 GO_SO_EXT:chromosome denotes chromosomes
T4902 29597-29605 GO:0007129 denotes synapsis
T4903 29618-29624 PR_EXT:000016672 denotes Trip13
T4904 29634-29641 SO_EXT:sequence_altered_entity denotes mutants
T4905 29681-29686 PR_EXT:000013672 denotes RAD51
T4906 29687-29691 PR_EXT:000006536 denotes DMC1
T4907 29701-29715 GO_PATO_EXT:phosphorylation_process_or_quality denotes phosphorylated
T4908 29716-29720 PR_EXT:000008418 denotes H2AX
T4909 29760-29764 PR_EXT:000006536 denotes Dmc1
T4910 29781-29787 PR_EXT:000016672 denotes Trip13
T4911 29796-29802 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4912 29803-29810 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T4913 29824-29831 UBERON:0000992 denotes ovaries
T4914 29846-29850 PR_EXT:000006536 denotes Dmc1
T4915 29851-29852 SO_EXT:sequence_nullness_or_absence denotes −
T4916 29853-29854 SO_EXT:sequence_nullness_or_absence denotes −
T4917 29859-29865 PR_EXT:000016672 denotes Trip13
T4918 29878-29885 SO_EXT:sequence_altered_entity denotes mutants
T5768 29907-29914 GO:0007126 denotes Meiotic
T5769 29926-29932 PR_EXT:000016672 denotes Trip13
T5770 29938-29945 CL:0000023 denotes Oocytes
T5771 29986-29993 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T5772 30048-30054 PR_EXT:000016672 denotes Trip13
T5773 30055-30062 SO_EXT:sequence_altered_entity denotes mutants
T5774 30069-30073 PR_EXT:000031227 denotes Mei1
T5775 30074-30075 SO_EXT:sequence_nullness_or_absence denotes −
T5776 30076-30077 SO_EXT:sequence_nullness_or_absence denotes −
T5777 30078-30084 PR_EXT:000016672 denotes Trip13
T5778 30094-30099 PR_EXT:000015553 denotes Spo11
T5779 30100-30101 SO_EXT:sequence_nullness_or_absence denotes −
T5780 30102-30103 SO_EXT:sequence_nullness_or_absence denotes −
T5781 30104-30110 PR_EXT:000016672 denotes Trip13
T5782 30116-30123 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T5783 30128-30135 UBERON:0000992 denotes ovaries
T5784 30150-30159 UBERON_EXT:follicle denotes follicles
T5785 30174-30178 PR_EXT:000031227 denotes Mei1
T5786 30183-30188 PR_EXT:000015553 denotes Spo11
T5787 30196-30203 SO_EXT:sequence_altered_entity denotes mutants
T5788 30226-30231 PR_EXT:000015553 denotes Spo11
T5789 30236-30240 PR_EXT:000031227 denotes Mei1
T5790 30258-30264 PR_EXT:000016672 denotes Trip13
T5791 30268-30277 GO:0048477 denotes oogenesis
T5792 30299-30303 PR_EXT:000006536 denotes Dmc1
T5793 30336-30342 CL:0000023 denotes oocyte
T5794 30351-30357 PR_EXT:000016672 denotes Trip13
T5795 30363-30370 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T5796 30492-30499 GO:0007126 denotes meiotic
T5797 30510-30516 PR_EXT:000016672 denotes Trip13
T5798 30517-30523 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5799 30524-30528 NCBITaxon:10088 denotes mice
T5800 30550-30560 GO:0006302 denotes DSB repair
T5801 30575-30582 UBERON:0000992 denotes ovaries
T5802 30586-30590 PR_EXT:000013858 denotes Rec8
T5803 30591-30597 PR_EXT:000016672 denotes Trip13
T5804 30605-30612 SO_EXT:sequence_altered_entity denotes mutants
T5805 30628-30635 CL:0000023 denotes oocytes
T5806 30669-30675 SO_EXT:sequence_altered_entity denotes mutant
T6227 30713-30720 SO_EXT:0000704 denotes Genetic
T6228 30736-30749 NCBITaxon:4932 denotes S. cerevisiae
T6229 30777-30797 GO:0051598 denotes pachytene checkpoint
T6230 30798-30806 GO:0065007 denotes monitors
T6231 30811-30819 GO_EXT:reaction_or_response denotes responds
T6232 30823-30838 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T6233 30823-30838 _FRAGMENT denotes recombinational
T6234 30843-30849 GO:0000725 denotes repair
T6235 30839-30849 GO:0006302 denotes DSB repair
T6236 30854-30862 GO:0007129 denotes synapsis
T6237 30912-30929 GO:0000077 denotes repair checkpoint
T6238 30933-30938 PR_EXT:000013665 denotes RAD17
T6239 30939-30943 PR_EXT:P46946 denotes SAE2
T6240 30965-30973 GO:0007129 denotes synapsis
T6241 30974-30984 GO:0000075 denotes checkpoint
T6242 30988-30992 PR_EXT:P38126 denotes PCH2
T6243 30993-30997 PR_EXT:P31111 denotes ZIP1
T6244 31028-31033 SO_EXT:0000704 denotes genes
T6245 31035-31039 PR_EXT:P46946 denotes SAE2
T6246 31044-31048 PR_EXT:P31111 denotes ZIP1
T6247 31067-31076 NCBITaxon:40674 denotes mammalian
T6248 31077-31086 SO_EXT:0000855 denotes orthologs
T6249 31097-31102 PR_EXT:000015862 denotes SYCP1
T6250 31123-31131 SO_EXT:0000855 denotes ortholog
T6251 31135-31139 PR_EXT:P31111 denotes ZIP1
T6252 31146-31154 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T6253 31162-31167 NCBITaxon:10088 denotes mouse
T6254 31168-31173 PR_EXT:000013665 denotes RAD17
T6255 31174-31182 SO_EXT:0000855 denotes ortholog
T6256 31184-31188 PR_EXT:P06777 denotes Rad1
T6257 31208-31217 UBERON:0000922 denotes embryonic
T6258 31218-31227 GO_EXT:fatality_or_lethality denotes lethality
T6259 31240-31250 SO_EXT:sequence_alteration_entity_or_process denotes mutational
T6260 31263-31268 NCBITaxon:10088 denotes mouse
T6261 31269-31273 PR_EXT:P38126 denotes Pch2
T6262 31275-31281 PR_EXT:000016672 denotes Trip13
T6263 31315-31323 GO:0007129 denotes synapsis
T6264 31324-31334 GO:0000075 denotes checkpoint
T6265 31338-31348 NCBITaxon:6239 denotes C. elegans
T6266 31417-31429 SO_EXT:biological_conservation_process_or_quality denotes conservation
T6267 31433-31442 NCBITaxon:40674 denotes mammalian
T6268 31443-31461 GO:0033313 denotes meiotic checkpoint
T6269 31462-31469 GO:0065007 denotes control
T6270 31503-31507 NCBITaxon:10088 denotes mice
T6271 31521-31528 GO:0007126 denotes meiotic
T6272 31541-31547 PR_EXT:000016672 denotes TRIP13
T6273 31554-31567 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6274 31620-31640 GO:0051598 denotes pachytene checkpoint
T6275 31641-31648 GO:0065007 denotes control
T6276 31678-31691 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6277 31726-31729 GO:0035825 denotes COs
T6278 31754-31760 PR_EXT:000016672 denotes Trip13
T6279 31761-31768 SO_EXT:sequence_altered_entity denotes mutants
T6280 31794-31800 GO:0006302 denotes repair
T6281 31919-31926 GO:0007126 denotes meiotic
T6282 31927-31940 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6283 31954-31967 NCBITaxon:4932 denotes S. cerevisiae
T6284 31969-31971 GO:0035825 denotes CO
T6285 32028-32041 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6286 32090-32098 CHEBI_PR_EXT:protein denotes proteins
T6287 32108-32112 NCBITaxon:10088 denotes Mice
T6288 32145-32147 _FRAGMENT denotes CO
T6289 32159-32172 GO:0007131 denotes recombination
T6290 32159-32172 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6291 32194-32199 NCBITaxon_EXT:yeast denotes yeast
T6292 32214-32219 PR_EXT:000015553 denotes SPO11
T6293 32228-32234 MOP:0000780 denotes breaks
T6294 32249-32251 GO:0035825 denotes CO
T6295 32269-32273 PR_EXT:000010442 denotes MLH1
T6296 32289-32300 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T6297 32333-32342 GO:0000239 denotes pachynema
T6298 32376-32389 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6299 32436-32449 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6300 32473-32483 GO:0006302 denotes DSB repair
T6301 32501-32508 GO:0007126 denotes meiotic
T6302 32509-32514 CL_GO_EXT:cell denotes cells
T6303 32528-32533 PR_EXT:000013680 denotes RAD54
T6304 32562-32575 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6305 32579-32584 NCBITaxon_EXT:yeast denotes yeast
T6306 32617-32624 GO:0007126 denotes meiosis
T6307 32635-32640 NCBITaxon_EXT:yeast denotes yeast
T6308 32644-32648 NCBITaxon:10088 denotes mice
T6309 32673-32678 PR_EXT:000013680 denotes RAD54
T6310 32689-32702 CL:0000017 denotes spermatocytes
T6311 32735-32740 PR_EXT:000013672 denotes RAD51
T6312 32749-32758 GO:0000239 denotes pachytene
T6313 32759-32770 GO_SO_EXT:chromosome denotes chromosomes
T6314 32792-32798 PR_EXT:000016672 denotes TRIP13
T6315 32799-32803 NCBITaxon:10088 denotes mice
T6316 32845-32852 GO:0007126 denotes meiotic
T6317 32894-32901 GO:0007114 denotes budding
T6318 32894-32907 NCBITaxon:4892 denotes budding yeast
T6319 32946-32959 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6320 32961-32969 SO_EXT:sequence_deletion_entity_or_process denotes Deletion
T6321 32973-32977 PR_EXT:P38126 denotes PCH2
T6322 32985-32992 GO:0007126 denotes meiotic
T6323 33020-33025 NCBITaxon_EXT:yeast denotes yeast
T6324 33058-33073 GO:0075317 denotes ascus formation
T6325 33114-33119 NCBITaxon_EXT:yeast denotes yeast
T6326 33128-33137 SO_EXT:wild_type_entity_or_quality denotes wild type
T6327 33188-33195 SO_EXT:sequence_altered_entity denotes mutants
T6328 33219-33224 CL_GO_EXT:cell denotes cells
T6329 33272-33277 NCBITaxon_EXT:yeast denotes yeast
T6330 33284-33293 GO:0007127 denotes meiosis I
T6331 33317-33322 PR_EXT:000013665 denotes RAD17
T6332 33323-33327 PR_EXT:P46946 denotes SAE2
T6333 33328-33338 GO:0000075 denotes checkpoint
T6334 33344-33352 GO:0065007 denotes monitors
T6335 33353-33366 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6336 33414-33420 PR_EXT:000016672 denotes TRIP13
T6337 33425-33429 PR_EXT:P38126 denotes Pch2
T6338 33434-33447 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6339 33468-33476 GO:0007129 denotes synapsis
T6340 33487-33493 PR_EXT:000016672 denotes TRIP13
T6341 33504-33517 CL:0000017 denotes spermatocytes
T6342 33565-33570 PR_EXT:000015553 denotes SPO11
T6343 33575-33579 PR_EXT:000031227 denotes MEI1
T6344 33598-33604 PR_EXT:000016672 denotes TRIP13
T6345 33653-33661 SO_EXT:sequence_substitution_process denotes exchange
T6346 33672-33685 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6347 33706-33708 GO:0035825 denotes CO
T6348 33709-33715 GO:0006281 denotes repair
T6349 33767-33769 CHEBI:44658 denotes OA
T6350 33799-33810 GO_SO_EXT:chromosome denotes chromosomes
T6351 33833-33839 PR_EXT:000016672 denotes TRIP13
T6352 33850-33863 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6353 33936-33949 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6354 33993-33999 PR_EXT:000016672 denotes TRIP13
T6355 34016-34030 _FRAGMENT denotes disassembly of
T6356 34058-34067 GO:0032984 denotes complexes
T6357 34035-34050 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T6358 34035-34057 GO:0000725 denotes recombinational repair
T6359 34058-34067 GO:0032991 denotes complexes
T6360 34090-34098 CHEBI_PR_EXT:protein denotes proteins
T6361 34126-34132 PR_EXT:000016672 denotes Trip13
T6362 34138-34147 GO:0000239 denotes pachytene
T6363 34148-34159 GO_SO_EXT:chromosome denotes chromosomes
T6364 34170-34176 PR_EXT:000016672 denotes TRIP13
T6365 34194-34200 GO_EXT:0016887 denotes ATPase
T6366 34201-34208 SO_EXT:0000417 denotes domains
T6367 34229-34235 GO_EXT:0016887 denotes ATPase
T6368 34236-34240 PR_EXT:000022296 denotes ClpA
T6369 34267-34274 CHEBI_PR_EXT:protein denotes protein
T6370 34267-34274 _FRAGMENT denotes protein
T6371 34290-34309 GO:0043241 denotes complex disassembly
T6372 34278-34285 CHEBI_PR_EXT:protein denotes protein
T6373 34278-34297 GO:0032993 denotes protein/DNA complex
T6374 34278-34309 GO:0032986 denotes protein/DNA complex disassembly
T6375 34286-34289 CHEBI_SO_EXT:DNA denotes DNA
T6376 34332-34345 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6377 34376-34383 GO:0007126 denotes meiosis
T6378 34391-34397 PR_EXT:000016672 denotes Trip13
T6379 34408-34419 GO_EXT:transcription denotes transcribed
T6380 34428-34434 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T6381 34435-34442 NCBITaxon:33208 denotes animals
T6382 34485-34491 PR_EXT:000016672 denotes TRIP13
T6383 34618-34625 GO:0007126 denotes meiosis
T6384 34650-34654 CL_GO_EXT:cell denotes cell
T6385 34650-34660 GO:0008219 denotes cell death
T6386 34664-34670 PR_EXT:000016672 denotes Trip13
T6387 34671-34678 SO_EXT:sequence_altered_entity denotes mutants
T6388 34734-34744 GO:0006302 denotes DSB repair
T6389 34758-34766 GO:0007129 denotes synapsis
T6390 34817-34823 CL:0000023 denotes oocyte
T6391 34824-34835 GO_EXT:killing denotes elimination
T6392 34876-34884 GO:0007129 denotes synapsis
T6393 34898-34911 CL:0000017 denotes spermatocytes
T6394 34915-34920 UBERON:0007023 denotes adult
T6395 34921-34927 UBERON:0000473 denotes testes
T6396 34942-34948 SO_EXT:sequence_altered_entity denotes mutant
T6397 34967-34980 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6398 35014-35022 GO:0007129 denotes synapsis
T6399 35036-35040 PR_EXT:000006536 denotes Dmc1
T6400 35063-35069 PR_EXT:000016672 denotes Trip13
T6401 35070-35076 SO_EXT:sequence_altered_entity denotes mutant
T6402 35112-35120 GO:0006281 denotes repaired
T6403 35121-35124 CHEBI_SO_EXT:DNA denotes DNA
T6404 35154-35163 NCBITaxon:40674 denotes mammalian
T6405 35164-35184 GO:0051598 denotes pachytene checkpoint
T6406 35185-35193 GO_EXT:reaction_or_response denotes response
T6407 35246-35253 CL:0000023 denotes oocytes
T6408 35258-35271 CL:0000017 denotes spermatocytes
T6409 35307-35310 CHEBI_SO_EXT:DNA denotes DNA
T6410 35307-35317 _FRAGMENT denotes DNA damage
T6411 35328-35338 GO:0000077 denotes checkpoint
T6412 35318-35338 GO:0051598 denotes pachytene checkpoint
T6413 35364-35372 GO:0007129 denotes synapsis
T6414 35373-35383 GO:0000075 denotes checkpoint
T6415 35414-35416 CHEBI:44658 denotes OA
T6416 35430-35436 PR_EXT:000016672 denotes Trip13
T6417 35442-35455 CL:0000017 denotes spermatocytes
T6418 35479-35481 GO:0007132 denotes MI
T6419 35533-35542 SO_EXT:wild_type_entity_or_quality denotes wild-type
T6420 35543-35552 GO:0000239 denotes pachytene
T6421 35553-35566 CL:0000017 denotes spermatocytes
T6422 35628-35637 CHEBI:4911 denotes etoposide
T6423 35697-35706 GO:0000239 denotes pachynema
T6424 35716-35726 GO:0000075 denotes checkpoint
T6425 35727-35735 GO_EXT:reaction_or_response denotes response
T6426 35763-35765 CHEBI:44658 denotes OA
T6427 35784-35799 GO:0042148 denotes strand invasion
T6428 35811-35817 PR_EXT:000016672 denotes TRIP13
T6429 35828-35841 CL:0000017 denotes spermatocytes
T6430 35850-35856 PR_EXT:000016672 denotes TRIP13
T6431 35908-35911 NCBITaxon:10114 denotes rat
T6432 35912-35919 UBERON:0002046 denotes thyroid
T6433 35912-35928 GO_EXT:0004887 denotes thyroid receptor
T6434 35912-35933 PR_EXT:000016321 denotes thyroid receptor beta
T6435 35935-35939 PR_EXT:000016321 denotes THRB
T6436 35977-35981 PR_EXT:000016321 denotes THRB
T6437 35986-35992 PR_EXT:000016672 denotes TRIP13
T6438 35996-36003 GO:0007126 denotes meiosis
T6439 36048-36052 PR_EXT:000016321 denotes THRB
T6440 36089-36098 SO_EXT:wild_type_entity_or_quality denotes wild-type
T6441 36099-36111 CL:0000017 denotes spermatocyte
T6442 36112-36118 GO:0005634 denotes nuclei
T6443 36144-36146 _FRAGMENT denotes XY
T6444 36153-36157 GO:0001741 denotes body
T6445 36148-36151 _FRAGMENT denotes sex
T6446 36206-36213 GO:0005634 denotes nuclear
T6447 36234-36243 GO:0000239 denotes pachynema
T6448 36258-36273 GO:0000803 denotes sex chromosomes
T6449 36262-36273 GO_SO_EXT:chromosome denotes chromosomes
T6450 36281-36300 GO:0031507 denotes heterochromatinized
T6451 36305-36331 GO:0006342 denotes transcriptionally silenced
T6452 36374-36381 GO:0001741 denotes XY body
T6453 36406-36412 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T6454 36413-36426 CL:0000017 denotes spermatocytes
T6455 36453-36460 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T6456 36464-36466 GO:0001741 denotes XY
T6457 36467-36489 GO:0031507 denotes heterochromatinization
T6458 36535-36539 PR_EXT:000016321 denotes THRB
T6459 36549-36553 NCBITaxon:10088 denotes mice
T6460 36619-36625 PR_EXT:000016672 denotes TRIP13
T6461 36634-36642 GO_EXT:0004872 denotes receptor
T6462 36643-36647 PR_EXT:000016321 denotes THRB
T6463 36651-36658 GO:0007126 denotes meiosis
T6464 36700-36704 PR_EXT:P38126 denotes PCH2
T6465 36705-36714 SO_EXT:0000855 denotes orthologs
T6466 36730-36740 NCBITaxon:2759 denotes eukaryotic
T6467 36788-36795 CHEBI_PR_EXT:protein denotes protein
T6468 36804-36813 SO_EXT:biological_conservation_process_or_quality denotes conserved
T6469 36821-36827 PR_EXT:000016672 denotes TRIP13
T6470 36845-36855 GO:0000075 denotes checkpoint
T6471 36868-36872 NCBITaxon:10088 denotes mice
T6472 36894-36900 PR_EXT:000016672 denotes TRIP13
T6473 36901-36905 PR_EXT:P38126 denotes PCH2
T6474 36916-36923 CHEBI_PR_EXT:protein denotes protein
T6475 36942-36955 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6476 36995-37006 NCBITaxon:3702 denotes A. thaliana
T6477 37033-37051 GO:0033313 denotes meiotic checkpoint
T6478 37066-37076 GO_EXT:killing denotes eliminates
T6479 37077-37083 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T6480 37119-37128 NCBITaxon:1 denotes organisms
T6481 37137-37141 NCBITaxon:10088 denotes mice
T6482 37143-37150 GO:0007114 denotes budding
T6483 37143-37156 NCBITaxon:4892 denotes budding yeast
T6484 37162-37168 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T6485 37169-37179 NCBITaxon:7215 denotes Drosophila
T6486 37193-37202 NCBITaxon:40674 denotes mammalian
T6487 37203-37209 PR_EXT:000016672 denotes TRIP13
T6488 37229-37240 NCBITaxon:3701 denotes Arabidopsis
T6489 37241-37245 PR_EXT:P38126 denotes PCH2
T6490 37255-37258 NCBITaxon:7147 denotes fly
T6491 37262-37266 NCBITaxon_EXT:worm denotes worm
T6492 37267-37275 CHEBI_PR_EXT:protein denotes proteins
T6493 37329-37338 NCBITaxon:40674 denotes mammalian
T6494 37343-37348 NCBITaxon:3193 denotes plant
T6495 37349-37353 PR_EXT:P38126 denotes PCH2
T6496 37417-37426 SO_EXT:biological_conservation_process_or_quality denotes conserved
T6497 37444-37457 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6498 37480-37484 PR_EXT:P38126 denotes PCH2
T6499 37488-37494 NCBITaxon:3193 denotes plants
T6500 37541-37551 GO:0000075 denotes checkpoint
T6501 37615-37622 NCBITaxon:33208 denotes animals
T6502 37624-37629 NCBITaxon:4751 denotes fungi
T6503 37635-37641 NCBITaxon:3193 denotes plants
T6504 37669-37673 PR_EXT:P38126 denotes PCH2
T6505 37674-37682 SO_EXT:biological_sequence denotes sequence
T6506 37762-37772 GO:0000075 denotes checkpoint
T6507 37786-37790 PR_EXT:P38126 denotes PCH2
T6508 37836-37846 GO:0000075 denotes checkpoint
T6509 37881-37886 NCBITaxon_EXT:worm denotes worms
T6510 37891-37898 GO:0007114 denotes budding
T6511 37891-37904 NCBITaxon:4892 denotes budding yeast
T6512 37957-37961 PR_EXT:P38126 denotes PCH2
T6513 37971-37980 NCBITaxon:1 denotes organisms
T6514 38014-38022 GO:0007129 denotes synapsis
T6515 38023-38033 GO:0000075 denotes checkpoint
T6516 38037-38041 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T6517 38042-38046 NCBITaxon:10088 denotes mice
T6518 38095-38099 PR_EXT:Q9SIH2 denotes Dot1
T6519 38101-38105 PR_EXT:Q04089 denotes PCH1
T6520 38109-38114 NCBITaxon_EXT:yeast denotes yeast
T6521 38119-38126 PR_EXT:000043452 denotes histone
T6522 38119-38126 CHEBI:15358 denotes histone
T6523 38119-38144 GO_EXT:0042054 denotes histone methyltransferase
T6524 38145-38154 GO:0016458 denotes silencing
T6525 38183-38192 GO:0000239 denotes pachytene
T6526 38203-38207 PR_EXT:P31111 denotes zip1
T6527 38212-38216 PR_EXT:000006536 denotes dmc1
T6528 38217-38224 SO_EXT:sequence_altered_entity denotes mutants
T6529 38228-38233 NCBITaxon_EXT:yeast denotes yeast
T6530 38259-38264 PR_EXT:000013680 denotes RAD54
T6531 38274-38289 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T6532 38274-38289 _FRAGMENT denotes recombinational
T6533 38294-38300 GO:0000725 denotes repair
T6534 38290-38300 GO:0006302 denotes DSB repair
T6535 38337-38341 PR_EXT:Q9SIH2 denotes DOT1
T6536 38359-38363 PR_EXT:P38126 denotes PCH2
T6537 38376-38382 PR_EXT:000016672 denotes TRIP13
T6538 38396-38406 GO:0000075 denotes checkpoint
T6539 38419-38423 NCBITaxon:10088 denotes mice
T6540 38446-38455 NCBITaxon:40674 denotes mammalian
T6541 38456-38460 PR_EXT:Q9SIH2 denotes DOT1
T6542 38468-38488 GO:0051598 denotes pachytene checkpoint
T6543 38558-38563 PR_EXT:000003035 denotes TRP53
T6544 38564-38571 SO_EXT:0000853 denotes homolog
T6545 38572-38577 PR_EXT:000016567 denotes TRP63
T6546 38594-38597 CHEBI_SO_EXT:DNA denotes DNA
T6547 38613-38618 GO:0016265 denotes death
T6548 38637-38655 CL:0000654 denotes primordial oocytes
T6549 38706-38716 GO:0065007 denotes monitoring
T6550 38717-38723 SO_EXT:0001026 denotes genome
T6551 38786-38806 GO:0051598 denotes pachytene checkpoint
T6552 38877-38895 GO:0033313 denotes meiotic checkpoint
T6553 38896-38901 SO_EXT:0000704 denotes genes
T6554 38905-38909 NCBITaxon:10088 denotes mice
T8141 39315-39321 UBERON:0000479 denotes Tissue
T8142 39322-39326 SO_EXT:cDNA denotes cDNA
T8143 39382-39389 SO_EXT:0000112 denotes primers
T8144 39476-39483 SO_EXT:0000112 denotes primers
T8145 39498-39503 SO_EXT:0000147 denotes exons
T8146 39545-39547 SO_EXT:0000028 denotes bp
T8147 39548-39552 SO_EXT:cDNA denotes cDNA
T8148 39566-39571 SO_EXT:cDNA denotes cDNAs
T8149 39634-39636 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T8272 39657-39663 PR_EXT:000016672 denotes Trip13
T8273 39674-39678 NCBITaxon:10088 denotes mice
T8274 39684-39689 NCBITaxon:10088 denotes mouse
T8275 39690-39699 UBERON:0000922 denotes embryonic
T8276 39690-39709 CL:0002322 denotes embryonic stem cell
T8277 39705-39709 CL_GO_EXT:cell denotes cell
T8278 39752-39761 SO_EXT:gene_trap_or_trap_construct denotes gene trap
T8279 39762-39771 SO_EXT:sequence_insertion_entity_or_process denotes insertion
T8280 39775-39781 PR_EXT:000016672 denotes Trip13
T8281 39852-39865 SO_EXT:gene_trapping_process denotes gene-trapping
T8282 39866-39872 SO_EXT:0000440 denotes vector
T8283 39934-39942 SO:0001817 denotes in-frame
T8284 39943-39949 SO_EXT:sequence_fusion_entity_or_process denotes fusion
T8285 39965-39970 SO_EXT:0000147 denotes exons
T8286 39986-39990 SO_EXT:0000704 denotes gene
T8287 40007-40011 GO_EXT:beta_geo denotes βgeo
T8288 40015-40021 SO_EXT:sequence_fusion_entity_or_process denotes fusion
T8289 40025-40040 GO_EXT:0004565 denotes β-galactosidase
T8290 40045-40053 CHEBI:7507 denotes neomycin
T8291 40045-40072 GO_EXT:0008910 denotes neomycin phosphotransferase
T8292 40082-40094 SO_EXT:gene_trapping_process denotes gene-trapped
T8293 40111-40128 SO_EXT:0001886 denotes fusion transcript
T8294 40140-40145 SO_EXT:0000147 denotes exons
T8295 40153-40159 PR_EXT:000016672 denotes Trip13
T8296 40164-40168 GO_EXT:beta_geo denotes βgeo
T8297 40192-40206 SO_EXT:0000366 denotes insertion site
T8298 40214-40220 SO_EXT:0000188 denotes intron
T8299 40252-40258 SO_EXT:0000112 denotes primer
T8300 40270-40279 SO_EXT:gene_trap_or_trap_construct denotes gene trap
T8301 40280-40286 SO_EXT:0000440 denotes vector
T8302 40302-40308 SO_EXT:0000112 denotes primer
T8303 40333-40339 SO_EXT:0000188 denotes intron
T8304 40377-40381 SO_EXT:0000704 denotes gene
T8305 40452-40466 SO_EXT:0000366 denotes insertion site
T8306 40475-40477 SO_EXT:0000028 denotes bp
T8307 40483-40489 SO_EXT:0000188 denotes intron
T8495 40508-40512 NCBITaxon:10088 denotes mice
T8496 40520-40527 SO_EXT:0000112 denotes primers
T8497 40553-40562 SO_EXT:wild_type_entity_or_quality denotes wild-type
T8498 40567-40573 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8499 40574-40581 SO_EXT:0001023 denotes alleles
T8500 40585-40591 PR_EXT:000016672 denotes Trip13
T8501 40593-40599 SO_EXT:0000112 denotes primer
T8502 40632-40638 SO_EXT:0000112 denotes primer
T8503 40687-40693 SO_EXT:0000112 denotes primer
T8504 40728-40735 SO_EXT:0000112 denotes Primers
T8505 40756-40764 SO_EXT:sequence_upstreamness denotes upstream
T8506 40769-40779 SO_EXT:sequence_downstreamness denotes downstream
T8507 40802-40811 SO_EXT:gene_trap_or_trap_construct denotes gene trap
T8508 40812-40821 SO_EXT:sequence_insertion_entity_or_process denotes insertion
T8509 40833-40839 SO_EXT:0000188 denotes intron
T8510 40843-40849 SO_EXT:0000112 denotes Primer
T8511 40874-40882 SO_EXT:biological_sequence denotes sequence
T8512 40884-40891 SO_EXT:0000112 denotes Primers
T8513 40914-40916 SO_EXT:0000028 denotes bp
T8514 40929-40938 SO_EXT:wild_type_entity_or_quality denotes wild-type
T8515 40939-40945 SO_EXT:0001023 denotes allele
T8516 40947-40954 SO_EXT:0000112 denotes primers
T8517 40977-40979 SO_EXT:0000028 denotes bp
T8518 40996-41002 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8519 41003-41009 SO_EXT:0001023 denotes allele
T8520 41097-41100 CHEBI_SO_EXT:DNA denotes DNA
T8702 41221-41223 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T8703 41235-41238 CHEBI_SO_EXT:RNA denotes RNA
T8704 41257-41262 UBERON:0007023 denotes adult
T8705 41263-41269 UBERON:0000473 denotes testes
T8706 41343-41348 CHEBI_SO_EXT:oligonucleotide denotes oligo
T8707 41349-41351 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes dT
T8708 41363-41382 GO:0001171 denotes reverse-transcribed
T8709 41455-41461 PR_EXT:000016672 denotes Trip13
T8710 41462-41469 CHEBI_PR_EXT:protein denotes protein
T8711 41462-41476 SO:0000010 denotes protein-coding
T8712 41470-41485 SO_EXT:coding_sequence denotes coding sequence
T8713 41505-41512 SO_EXT:0000112 denotes primers
T8714 41683-41690 SO_EXT:0000112 denotes primers
T8715 41710-41715 PR_EXT:000010303 denotes Med31
T8716 41716-41731 SO_EXT:coding_sequence denotes coding sequence
T8901 41939-41950 _FRAGMENT denotes Development
T8902 41968-41970 _FRAGMENT denotes of
T8903 41979-41989 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes antibodies
T8904 41971-41978 NCBITaxon:9031 denotes chicken
T8905 41979-41989 GO:0042571 denotes antibodies
T8906 41993-42000 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T8907 42018-42029 CHEBI_SO_EXT:amino_acid denotes amino acids
T8908 42039-42045 PR_EXT:000016672 denotes TRIP13
T8909 42068-42078 MOP:0000779 denotes conjugated
T8910 42107-42115 NCBITaxon:9031 denotes chickens
T8911 42181-42184 GO:0071760 denotes IgY
T8912 42203-42207 UBERON:0007379 denotes eggs
T8913 42228-42235 NCBITaxon:9031 denotes Chicken
T8914 42236-42239 GO:0071760 denotes IgY
T8915 42293-42296 GO:0071760 denotes IgY
T8916 42297-42307 GO:0042571 denotes antibodies
T8917 42367-42374 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T9005 42404-42410 UBERON:0000473 denotes testis
T9006 42427-42433 CHEBI_CHMO_EXT:buffer_solution denotes buffer
T9007 42454-42457 CHEBI:8984 denotes SDS
T9008 42498-42512 CHEBI:53325 denotes Nitrocellulose
T9009 42601-42607 NCBITaxon:9986 denotes rabbit
T9010 42613-42618 NCBITaxon:9606 denotes human
T9011 42619-42625 PR_EXT:000016672 denotes TRIP13
T9012 42626-42634 GO:0042571 denotes antibody
T9013 42720-42729 CHEBI_EXT:60816 denotes immunogen
T9014 42746-42753 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T9015 42766-42774 SO_EXT:biological_sequence denotes sequence
T9016 42803-42807 SO_EXT:0000147 denotes exon
T9017 42811-42818 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes Binding
T9018 42878-42884 NCBITaxon:9986 denotes rabbit
T9019 42890-42897 NCBITaxon:9031 denotes chicken
T9020 42898-42901 GO:0071735 denotes IgG
T9021 42902-42913 NCBITaxon:3704 denotes horseradish
T9022 42914-42924 GO_EXT:0004601 denotes peroxidase
T9023 42925-42934 CHEBI:64985 denotes conjugate
T9268 43369-43382 CL:0000017 denotes spermatocytes
T9269 43387-43394 CL:0000023 denotes oocytes
T9270 43491-43499 CHEBI_PR_EXT:protein denotes proteins
T9271 43545-43551 GO:0005634 denotes nuclei
T9272 43566-43580 GO:0098762 denotes meiotic stages
T9273 43652-43657 PR_EXT:000015865 denotes SYCP3
T9274 43661-43666 PR_EXT:000015706 denotes STAG3
T9275 43756-43764 CHEBI_PR_EXT:protein denotes proteins
T9276 43793-43798 PR_EXT:000013672 denotes RAD51
T9277 43802-43805 GO:0005662 denotes RPA
T9278 43980-43984 PR_EXT:000010442 denotes MLH1
T9279 43988-43992 PR_EXT:000010443 denotes MLH3
T9280 43998-44003 PR_EXT:000013672 denotes RAD51
T9281 44019-44024 PR_EXT:000015865 denotes SYCP3
T9282 44028-44033 PR_EXT:000015706 denotes STAG3
T9283 44060-44070 GO_SO_EXT:chromosome denotes chromosome
T9284 44079-44085 GO:0005634 denotes Nuclei
T9285 44129-44133 PR_EXT:000010442 denotes MLH1
T9286 44207-44217 GO:0042571 denotes antibodies
T9287 44254-44259 NCBITaxon:10088 denotes mouse
T9288 44265-44269 PR_EXT:000015865 denotes SCP3
T9289 44308-44314 NCBITaxon:9986 denotes rabbit
T9290 44320-44325 PR_EXT:000015862 denotes SYCP1
T9291 44366-44372 NCBITaxon:9986 denotes rabbit
T9292 44378-44382 PR_EXT:000013858 denotes REC8
T9293 44416-44422 NCBITaxon:9986 denotes rabbit
T9294 44428-44433 PR_EXT:000013672 denotes RAD51
T9295 44458-44466 GO:0042571 denotes antibody
T9296 44483-44488 PR_EXT:000013672 denotes RAD51
T9297 44493-44497 PR_EXT:000006536 denotes DMC1
T9298 44563-44569 NCBITaxon:9986 denotes rabbit
T9299 44638-44644 NCBITaxon:9986 denotes rabbit
T9300 44650-44655 PR_EXT:000015706 denotes STAG3
T9301 44694-44700 NCBITaxon:9986 denotes rabbit
T9302 44706-44710 PR_EXT:000010443 denotes MLH3
T9303 44742-44747 NCBITaxon:10088 denotes mouse
T9304 44753-44758 NCBITaxon:9606 denotes human
T9305 44759-44763 PR_EXT:000010442 denotes MLH1
T9306 44818-44824 NCBITaxon:9986 denotes rabbit
T9307 44830-44836 PR_EXT:000016548 denotes TopBP1
T9308 44872-44877 NCBITaxon:10088 denotes mouse
T9309 44893-44900 CHEBI:15358 denotes histone
T9310 44893-44904 PR_EXT:000027547 denotes histone H2A
T9311 44937-44943 NCBITaxon:9986 denotes rabbit
T9312 44949-44953 PR_EXT:000016236 denotes TRF2
T9313 44992-44998 NCBITaxon:9986 denotes rabbit
T9314 45004-45007 PR_EXT:000004759 denotes BLM
T9315 45053-45063 GO:0042571 denotes antibodies
T9316 45064-45074 MOP:0000779 denotes conjugated
T9317 45087-45102 CHEBI:52661 denotes Alexa Fluor 488
T9318 45087-45098 _FRAGMENT denotes Alexa Fluor
T9319 45106-45109 CHEBI:51248 denotes 594
T9320 45111-45120 CHEBI_EXT:polyatomic_entity_or_group denotes Molecular
T9321 45121-45127 CHEBI_SO_EXT:molecular_probe denotes Probes
T9737 45267-45278 GO:0007132 denotes Metaphase I
T9738 45279-45291 CL:0000017 denotes spermatocyte
T9739 45304-45306 CHEBI:44658 denotes OA
T9740 45318-45327 GO:0051323 denotes Metaphase
T9741 45334-45347 CL:0000017 denotes spermatocytes
T9742 45362-45368 PR_EXT:000016672 denotes Trip13
T9743 45403-45412 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9744 45413-45417 NCBITaxon:10088 denotes mice
T9745 45491-45493 CHEBI:44658 denotes OA
T9746 45505-45510 CL_GO_EXT:cell denotes cells
T9747 45532-45534 CHEBI:44658 denotes OA
T9748 45630-45633 CHEBI:16526 denotes CO2
T9749 45694-45698 CHEBI:51231 denotes DAPI
T9750 45712-45721 GO:0051323 denotes metaphase
T9751 45722-45728 GO:0005634 denotes nuclei
T9752 45733-45744 GO_SO_EXT:chromosome denotes chromosomes
T9856 45770-45776 PR_EXT:000016672 denotes TRIP13
T9857 45777-45786 SO_EXT:0000855 denotes orthologs
T9858 45861-45865 SO_EXT:0000704 denotes gene
T9859 45903-45912 SO_EXT:0000855 denotes orthologs
T9860 45939-45949 CHEBI_SO_EXT:amino_acid denotes Amino acid
T9861 46071-46077 GO_EXT:0016887 denotes ATPase
T9862 46086-46092 SO_EXT:0000417 denotes domain
T9863 46283-46287 SO_EXT:0000730 denotes gaps
T10066 7433-7438 NCBITaxon:10088 denotes Mouse
T10067 7439-7443 PR_EXT:P38126 denotes PCH2
T10068 7444-7452 SO_EXT:0000855 denotes Ortholog
T10069 7453-7459 PR_EXT:000016672 denotes TRIP13
T10070 7464-7474 GO:0010467 denotes Expression
T10071 7478-7487 SO_EXT:wild_type_entity_or_quality denotes Wild Type
T10072 7492-7498 SO_EXT:sequence_altered_entity denotes Mutant
T10073 7533-7537 PR_EXT:P38126 denotes PCH2
T10074 7538-7544 PR_EXT:000016672 denotes TRIP13
T10075 7545-7554 SO_EXT:0000855 denotes orthologs
T10076 7569-7577 SO_EXT:biological_sequence denotes sequence
T10077 7603-7610 CHEBI_PR_EXT:protein denotes protein
T10078 7768-7770 CHEBI_SO_EXT:amino_acid denotes AA
T10079 7771-7779 SO_EXT:biological_sequence denotes sequence
T10080 7791-7800 SO_EXT:biological_sequence denotes sequences
T10081 7831-7843 SO_EXT:biological_conservation_process_or_quality denotes conservation
T10082 7892-7902 NCBITaxon:2759 denotes eukaryotic
T10083 7939-7952 NCBITaxon:33511 denotes deuterostomia
T10084 7962-7968 NCBITaxon:3193 denotes plants
T10085 7979-7990 NCBITaxon:33317 denotes protostomia
T10086 8006-8011 NCBITaxon:4751 denotes fungi
T10087 8053-8057 SO_EXT:cDNA denotes cDNA
T10088 8077-8084 UBERON:0000479 denotes tissues
T10089 8089-8094 UBERON:0000948 denotes heart
T10090 8099-8104 UBERON:0000955 denotes brain
T10091 8109-8115 UBERON:0002106 denotes spleen
T10092 8120-8124 UBERON:0002048 denotes lung
T10093 8129-8134 UBERON:0002107 denotes liver
T10094 8139-8154 UBERON_EXT:skeletal_muscle_organ_or_tissue denotes skeletal muscle
T10095 8159-8165 UBERON:0002113 denotes kidney
T10096 8170-8176 UBERON:0000473 denotes testis
T10097 8184-8190 UBERON:0000922 denotes embryo
T10098 8200-8206 UBERON:0000922 denotes embryo
T10099 8216-8222 UBERON:0000922 denotes embryo
T10100 8236-8242 UBERON:0000922 denotes embryo
T10101 8248-8254 SO_EXT:0000188 denotes Intron
T10102 8255-8259 SO_EXT:0000147 denotes exon
T10103 8273-8279 PR_EXT:000016672 denotes TRIP13
T10104 8284-8298 SO_EXT:0000366 denotes insertion site
T10105 8302-8311 SO_EXT:gene_trap_or_trap_construct denotes gene-trap
T10106 8312-8318 SO_EXT:0000440 denotes vector
T10107 8377-8391 SO_EXT:0000366 denotes insertion site
T10108 8412-8414 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T10109 8422-8428 PR_EXT:000016672 denotes Trip13
T10110 8443-8447 SO_EXT:0000704 denotes gene
T10111 8448-8453 PR_EXT:000010303 denotes Med31
T10112 8459-8465 UBERON:0000473 denotes testis
T10113 8466-8469 CHEBI_SO_EXT:RNA denotes RNA
T10114 8475-8481 PR_EXT:000016672 denotes Trip13
T10115 8482-8489 SO_EXT:0000112 denotes primers
T10116 8525-8530 SO_EXT:0000147 denotes exons
T10117 8589-8595 UBERON:0000473 denotes testis
T10118 8596-8603 CHEBI_PR_EXT:protein denotes protein
T10119 8614-8620 PR_EXT:000016672 denotes TRIP13
T10120 8621-8629 GO:0042571 denotes antibody
T10121 8673-8680 PR_EXT:000028799 denotes tubulin
T10122 8722-8728 PR_EXT:000016672 denotes TRIP13
T10123 8729-8736 CHEBI_PR_EXT:protein denotes protein
T10124 8753-8765 GO_PATO_EXT:biological_localization_process_or_quality denotes Localization
T10125 8769-8775 PR_EXT:000016672 denotes TRIP13
T10126 8779-8785 UBERON:0000473 denotes testes
T10127 8787-8796 SO_EXT:wild_type_entity_or_quality denotes Wild-type
T10128 8807-8813 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T10129 8823-8829 UBERON:0000473 denotes testis
T10130 8856-8863 NCBITaxon:9031 denotes chicken
T10131 8869-8875 PR_EXT:000016672 denotes TRIP13
T10132 8899-8909 MOP:0000779 denotes conjugated
T10133 8915-8922 NCBITaxon:9031 denotes chicken
T10134 8923-8926 GO:0071735 denotes IgG
T10135 8949-8959 GO:0010467 denotes Expression
T10136 8963-8965 SO_EXT:wild_type_entity_or_quality denotes WT
T10137 8992-8998 GO:0005634 denotes nuclei
T10138 9009-9022 CL:0000020 denotes spermatogonia
T10139 9024-9026 CL:0000020 denotes Sg
T10140 9029-9038 GO:0000237 denotes leptotene
T10141 9039-9052 CL:0000017 denotes spermatocytes
T10142 9069-9078 GO:0000239 denotes pachytene
T10143 9079-9092 CL:0000017 denotes spermatocytes
T10144 9112-9121 GO:0000239 denotes pachytene
T10145 9122-9135 CL:0000017 denotes spermatocytes
T10146 9145-9152 GO:0005634 denotes nuclear
T10147 9174-9180 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T10148 9181-9187 UBERON:0000473 denotes testis
T10149 9215-9226 GO:0005737 denotes cytoplasmic
T10150 9268-9272 CL_GO_EXT:cell denotes cell
T10151 9316-9326 UBERON:0000483 denotes epithelial
T10152 9340-9347 UBERON:0000025 denotes tubules
T10153 9371-9377 PR_EXT:000016672 denotes TRIP13
T10154 9378-9390 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T10155 9409-9422 CL:0000017 denotes spermatocytes
T10156 9466-9471 PR_EXT:000015865 denotes SYCP3
T10157 9473-9474 PR_EXT:000015865 denotes S
T10158 9480-9486 PR_EXT:000016672 denotes TRIP13
T10159 9488-9489 PR_EXT:000016672 denotes T
T10160 9540-9549 GO:0000237 denotes leptotene
T10161 9551-9554 GO:0000237 denotes Lep
T10162 9557-9565 GO:0000238 denotes zygotene
T10163 9567-9570 GO:0000238 denotes Zyg
T10164 9577-9586 GO:0000239 denotes pachytene
T10165 9588-9591 GO:0000239 denotes Pac
T10166 9593-9606 CL:0000017 denotes spermatocytes
T10167 9608-9615 GO:0005634 denotes Nuclear
T10168 9643-9649 SO_EXT:sequence_altered_entity denotes mutant
T10666 10410-10416 PR_EXT:000016672 denotes Trip13
T10667 10417-10423 SO_EXT:sequence_altered_entity_or_alteration_process denotes Mutant
T10668 10424-10428 NCBITaxon:10088 denotes Mice
T10669 10484-10488 UBERON:0002415 denotes tail
T10670 10496-10502 SO_EXT:sequence_altered_entity denotes mutant
T10671 10524-10528 UBERON_EXT:body denotes body
T10672 10575-10581 SO_EXT:sequence_altered_entity denotes mutant
T10673 10615-10619 UBERON:0002415 denotes tail
T10674 10630-10639 SO_EXT:sequence_truncation_process denotes truncated
T10675 10647-10652 NCBITaxon:10088 denotes mouse
T10676 10665-10674 SO_EXT:wild_type_entity_or_quality denotes Wild-type
T10677 10676-10678 SO_EXT:wild_type_entity_or_quality denotes WT
T10678 10695-10701 PR_EXT:000016672 denotes Trip13
T10679 10702-10708 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T10680 10710-10713 SO_EXT:sequence_altered_entity_or_alteration_process denotes MUT
T10681 10715-10721 UBERON:0000473 denotes testes
T10682 10788-10790 SO_EXT:wild_type_entity_or_quality denotes WT
T10683 10808-10814 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T10684 10815-10821 PR_EXT:000016672 denotes Trip13
T10685 10822-10828 UBERON:0000473 denotes testes
T10686 10856-10863 UBERON:0000025 denotes tubules
T10687 10867-10869 SO_EXT:wild_type_entity_or_quality denotes WT
T10688 10887-10902 GO:0007283 denotes spermatogenesis
T10689 10908-10917 GO:0000239 denotes pachytene
T10690 10918-10931 CL:0000017 denotes spermatocytes
T10691 10947-10954 UBERON:0000025 denotes tubules
T10692 10972-10977 GO_UBERON_EXT:lumen denotes lumen
T10693 11013-11019 SO_EXT:sequence_altered_entity denotes mutant
T10694 11048-11055 UBERON:0000025 denotes tubules
T10695 11062-11069 UBERON:0000025 denotes tubules
T10696 11078-11087 GO:0000239 denotes pachytene
T10697 11088-11100 CL:0000017 denotes spermatocyes
T10951 13795-13801 SO_EXT:sequence_altered_entity_or_alteration_process denotes Mutant
T10952 13802-13808 UBERON:0000991 denotes Gonads
T10953 13817-13828 CHEBI:51686 denotes hematoxylin
T10954 13829-13834 CHEBI_EXT:eosin denotes eosin
T10955 13862-13868 UBERON:0000473 denotes Testes
T10956 13887-13892 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T10957 13925-13934 SO_EXT:wild_type_entity_or_quality denotes Wild-type
T10958 13944-13949 UBERON:0000992 denotes ovary
T10959 13955-13961 PR_EXT:000016672 denotes Trip13
T10960 13977-13982 UBERON:0000992 denotes ovary
T10961 14022-14029 CL:0000023 denotes oocytes
T10962 14035-14041 PR_EXT:000016672 denotes Trip13
T10963 14044-14045 SO_EXT:normal_or_wild_type_or_present denotes +
T10964 14062-14067 UBERON:0000992 denotes ovary
T10965 14085-14092 CL:0000023 denotes oocytes
T10966 14110-14119 UBERON_EXT:follicle denotes follicles
T10967 14125-14131 PR_EXT:000016672 denotes Trip13
T10968 14145-14150 UBERON:0000992 denotes ovary
T10969 14176-14183 CL:0000023 denotes oocytes
T10970 14241-14250 SO_EXT:wild_type_entity_or_quality denotes Wild-type
T10971 14251-14257 UBERON:0000473 denotes testis
T10972 14263-14269 PR_EXT:000016672 denotes Trip13
T10973 14275-14281 UBERON:0000473 denotes testis
T10974 14295-14304 GO:0000239 denotes pachytene
T10975 14317-14323 PR_EXT:000016672 denotes Trip13
T10976 14338-14344 UBERON:0000473 denotes testis
T10977 14359-14366 GO:0007126 denotes meiotic
T10978 14367-14377 CL:0000018 denotes spermatids
T10979 14392-14397 PR_EXT:000015553 denotes Spo11
T10980 14397-14398 SO_EXT:sequence_nullness_or_absence denotes −
T10981 14399-14400 SO_EXT:sequence_nullness_or_absence denotes -
T10982 14401-14407 UBERON:0000473 denotes testis
T10983 14411-14417 UBERON:0000025 denotes tubule
T10984 14423-14436 CL:0000017 denotes spermatocytes
T10985 14440-14449 GO:0000237 denotes leptotene
T10986 14450-14458 GO:0000238 denotes zygotene
T10987 14489-14496 UBERON:0000025 denotes tubules
T10988 14502-14511 GO_PATO_EXT:apoptotic_process_or_quality denotes apoptotic
T10989 14512-14525 CL:0000017 denotes spermatocytes
T10990 14616-14621 PR_EXT:000015553 denotes Spo11
T10991 14622-14623 SO_EXT:sequence_nullness_or_absence denotes −
T10992 14624-14625 SO_EXT:sequence_nullness_or_absence denotes −
T10993 14626-14632 PR_EXT:000016672 denotes Trip13
T10994 14638-14644 UBERON:0000473 denotes testis
T10995 14699-14705 UBERON:0000025 denotes tubule
T10996 14711-14720 GO:0000237 denotes leptotene
T10997 14721-14729 GO:0000238 denotes zygotene
T10998 14730-14743 CL:0000017 denotes spermatocytes
T10999 14749-14753 PR_EXT:000031227 denotes Mei1
T11000 14754-14755 SO_EXT:sequence_nullness_or_absence denotes −
T11001 14756-14757 SO_EXT:sequence_nullness_or_absence denotes −
T11002 14758-14764 PR_EXT:000016672 denotes Trip13
T11003 14767-14768 SO_EXT:normal_or_wild_type_or_present denotes +
T11004 14769-14775 UBERON:0000473 denotes testis
T11005 14838-14842 PR_EXT:000031227 denotes Mei1
T11006 14843-14844 SO_EXT:sequence_nullness_or_absence denotes −
T11007 14845-14846 SO_EXT:sequence_nullness_or_absence denotes −
T11008 14847-14853 PR_EXT:000016672 denotes Trip13
T11009 14859-14865 UBERON:0000473 denotes testis
T11010 14871-14875 PR_EXT:000013858 denotes Rec8
T11011 14880-14884 PR_EXT:000013858 denotes Rec8
T11012 14889-14895 PR_EXT:000016672 denotes Trip13
T11013 14898-14899 SO_EXT:normal_or_wild_type_or_present denotes +
T11014 14900-14906 UBERON:0000473 denotes testis
T11015 14912-14916 PR_EXT:000013858 denotes Rec8
T11016 14921-14927 SO_EXT:0001023 denotes allele
T11017 15009-15013 PR_EXT:000013858 denotes Rec8
T11018 15018-15022 PR_EXT:000013858 denotes Rec8
T11019 15027-15033 PR_EXT:000016672 denotes Trip13
T11020 15039-15045 UBERON:0000473 denotes testis
T11021 15051-15055 PR_EXT:000006536 denotes Dmc1
T11022 15056-15057 SO_EXT:sequence_nullness_or_absence denotes −
T11023 15058-15059 SO_EXT:sequence_nullness_or_absence denotes −
T11024 15060-15066 PR_EXT:000016672 denotes Trip13
T11025 15072-15078 UBERON:0000473 denotes testis
T11026 15084-15089 PR_EXT:000015553 denotes Spo11
T11027 15090-15091 SO_EXT:sequence_nullness_or_absence denotes −
T11028 15092-15093 SO_EXT:sequence_nullness_or_absence denotes −
T11029 15094-15100 PR_EXT:000016672 denotes Trip13
T11030 15103-15104 SO_EXT:normal_or_wild_type_or_present denotes +
T11031 15114-15119 UBERON:0000992 denotes ovary
T11032 15182-15187 PR_EXT:000015553 denotes Spo11
T11033 15188-15189 SO_EXT:sequence_nullness_or_absence denotes −
T11034 15190-15191 SO_EXT:sequence_nullness_or_absence denotes −
T11035 15192-15198 PR_EXT:000016672 denotes Trip13
T11036 15213-15218 UBERON:0000992 denotes ovary
T11037 15224-15228 PR_EXT:000031227 denotes Mei1
T11038 15229-15230 SO_EXT:sequence_nullness_or_absence denotes −
T11056 15507-15512 UBERON:0000992 denotes ovary
T11616 17678-17687 GO:0000239 denotes Pachytene
T11617 17688-17700 CL:0000017 denotes Spermatocyte
T11618 17701-17712 GO_SO_EXT:chromosome denotes Chromosomes
T11619 17728-17739 GO_SO_EXT:chromosome denotes chromosomes
T11620 17778-17788 GO:0042571 denotes antibodies
T11621 17793-17805 CHEBI_EXT:51217 denotes fluorophores
T11622 17854-17859 CL_GO_EXT:cell denotes cells
T11623 17870-17879 SO_EXT:wild_type_entity_or_quality denotes wild type
T11624 17881-17883 SO_EXT:wild_type_entity_or_quality denotes WT
T11625 17892-17893 SO_EXT:normal_or_wild_type_or_present denotes +
T11626 17894-17895 SO_EXT:normal_or_wild_type_or_present denotes +
T11627 17899-17905 PR_EXT:000016672 denotes Trip13
T11628 17908-17909 SO_EXT:normal_or_wild_type_or_present denotes +
T11629 17914-17920 PR_EXT:000016672 denotes Trip13
T11630 17990-17991 SO_EXT:normal_or_wild_type_or_present denotes +
T11631 17992-17993 SO_EXT:normal_or_wild_type_or_present denotes +
T11632 17994-18007 CL:0000017 denotes spermatocytes
T11633 18015-18021 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T11634 18022-18031 GO:0000239 denotes pachytene
T11635 18032-18039 GO:0005634 denotes nucleus
T11636 18050-18058 GO:0007129 denotes synapsis
T11637 18069-18074 PR_EXT:000015862 denotes SYCP1
T11638 18075-18080 PR_EXT:000015865 denotes SYCP3
T11639 18083-18091 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeling
T11640 18110-18123 CL:0000017 denotes Spermatocytes
T11641 18124-18131 GO:0005634 denotes nucleus
T11642 18148-18154 GO:0007567 denotes partum
T11643 18155-18161 SO_EXT:sequence_altered_entity denotes mutant
T11644 18164-18172 GO:0007129 denotes synapsed
T11645 18173-18184 GO_SO_EXT:chromosome denotes chromosomes
T11646 18188-18210 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes regions of chromosomes
T11647 18301-18310 SO_EXT:wild_type_entity_or_quality denotes wild-type
T11648 18311-18320 GO:0000239 denotes pachytene
T11649 18321-18334 CL:0000017 denotes spermatocytes
T11650 18340-18343 PR_EXT:000004759 denotes BLM
T11651 18364-18372 GO:0007129 denotes synapsed
T11652 18373-18382 GO:0000239 denotes pachytene
T11653 18383-18394 GO_SO_EXT:chromosome denotes chromosomes
T11654 18402-18408 SO_EXT:sequence_altered_entity denotes mutant
T11655 18414-18419 PR_EXT:000013672 denotes RAD51
T11656 18456-18464 GO:0051324 denotes prophase
T11657 18481-18490 GO:0030849 denotes autosomes
T11658 18494-18503 SO_EXT:wild_type_entity_or_quality denotes wild-type
T11659 18504-18513 GO:0000239 denotes pachytene
T11660 18514-18520 GO:0005634 denotes nuclei
T11661 18562-18569 GO:0001741 denotes XY body
T11662 18583-18588 PR_EXT:000013672 denotes RAD51
T11663 18605-18613 GO:0007129 denotes synapsed
T11664 18614-18620 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T11665 18621-18632 GO_SO_EXT:chromosome denotes chromosomes
T11666 18647-18651 PR_EXT:000008418 denotes H2AX
T11667 18652-18667 GO_PATO_EXT:phosphorylation_process denotes phosphorylation
T11668 18689-18696 GO:0001741 denotes XY body
T11669 18700-18702 SO_EXT:wild_type_entity_or_quality denotes WT
T11670 18771-18778 GO:0001741 denotes XY body
T11671 18799-18808 GO:0030849 denotes autosomal
T11672 18809-18813 PR_EXT:000008418 denotes H2AX
T11673 18814-18829 GO_PATO_EXT:phosphorylation_process denotes phosphorylation
T11674 18860-18869 SO_EXT:wild_type_entity_or_quality denotes wild-type
T11675 18870-18879 GO:0000239 denotes pachytene
T11676 18880-18893 CL:0000017 denotes spermatocytes
T11677 18895-18901 PR_EXT:000016548 denotes TOPBP1
T11678 18927-18934 GO:0001741 denotes XY body
T11679 18958-18964 SO_EXT:sequence_altered_entity denotes mutant
T11680 19039-19054 GO:0000803 denotes sex chromosomes
T11681 19043-19054 GO_SO_EXT:chromosome denotes chromosomes
T11682 19071-19081 GO_SO_EXT:chromosome denotes chromosome
T11683 19119-19122 GO:0005662 denotes RPA
T11684 19138-19146 GO:0007129 denotes synapsed
T11685 19160-19166 SO_EXT:sequence_altered_entity denotes mutant
T11686 19172-19174 SO_EXT:wild_type_entity_or_quality denotes WT
T11687 19211-19215 PR_EXT:000010443 denotes MLH3
T11688 19224-19227 GO:0000795 denotes SCs
T11689 19236-19238 SO_EXT:wild_type_entity_or_quality denotes WT
T11690 19244-19253 GO:0000239 denotes pachytene
T11691 19254-19267 CL:0000017 denotes spermatocytes
T11692 19269-19274 PR_EXT:000013672 denotes RAD51
T11693 19338-19343 PR_EXT:000013672 denotes RAD51
T11694 19364-19367 GO:0000795 denotes SCs
T11695 19371-19377 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T11696 19378-19387 GO:0000239 denotes pachytene
T11697 19388-19394 GO:0005634 denotes nuclei
T11698 19422-19426 PR_EXT:000010442 denotes MLH1
T11699 19434-19442 GO_PATO_EXT:biological_localization_process_or_quality denotes localize
T11700 19498-19508 GO_SO_EXT:chromosome denotes chromosome
T8137 39239-39245 PR_EXT:000016672 denotes Trip13
T8138 39246-39250 SO_EXT:cDNA denotes cDNA
T8139 39252-39258 PR_EXT:000016672 denotes Trip13
T8140 39300-39305 NCBITaxon:10088 denotes Mouse
T9137 42969-42975 UBERON:0000473 denotes Testes
T9138 42979-42986 UBERON:0000992 denotes ovaries
T9139 43066-43077 CHEBI:51686 denotes hematoxylin
T9140 43082-43087 CHEBI_EXT:eosin denotes eosin
T9141 43089-43096 CHEBI_EXT:59132 denotes Antigen
T9142 43135-43141 UBERON:0000473 denotes testis
T9143 43174-43180 CL:0000023 denotes Oocyte
T9144 43185-43193 UBERON_EXT:follicle denotes follicle
T9145 43239-43248 UBERON_EXT:follicle denotes follicles
T9146 43263-43269 CL:0000023 denotes oocyte
T9147 43293-43300 GO:0005634 denotes nucleus
T12119 27034-27040 PR_EXT:000016672 denotes Trip13
T12120 27050-27057 SO_EXT:sequence_altered_entity denotes Mutants
T12121 27073-27084 GO_SO_EXT:chromosome denotes chromosomes
T12122 27123-27133 GO:0042571 denotes antibodies
T12123 27138-27150 CHEBI_EXT:51217 denotes fluorophores
T12124 27152-27161 SO_EXT:genotype_or_entity_with_genotype denotes Genotypes
T12125 27307-27313 GO:0005634 denotes nuclei
T2263 13446-13453 CL:0000023 denotes oocytes
T1362 6554-6560 PR_EXT:000016672 denotes Trip13
T2264 13471-13480 UBERON_EXT:follicle denotes follicles
T2250 12995-13002 GO:0007126 denotes Meiotic
T2251 13017-13023 PR_EXT:000016672 denotes TRIP13
T2252 13080-13086 UBERON:0000991 denotes gonads
T2253 13139-13146 UBERON:0000992 denotes Ovaries
T2254 13150-13155 UBERON:0007023 denotes adult
T2255 13156-13162 PR_EXT:000016672 denotes Trip13
T2256 13168-13175 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T2257 13219-13228 UBERON_EXT:follicle denotes follicles
T2258 13265-13271 CL:0000023 denotes oocyte
T2259 13294-13307 GO:0009790 denotes embryogenesis
T2260 13324-13329 GO:0007567 denotes natal
T2261 13357-13363 GO:0007567 denotes partum
T2262 13364-13371 UBERON:0000992 denotes ovaries
T2265 13507-13514 CL:0000023 denotes oocytes
T2266 13585-13592 CL:0000023 denotes oocytes
T2267 13598-13607 GO:0000239 denotes pachytene
T2268 13614-13625 GO_SO_EXT:chromosome denotes chromosomes
T2269 13636-13642 PR_EXT:000016672 denotes Trip13
T2270 13648-13657 UBERON:0000922 denotes embryonic
T2271 13658-13665 UBERON:0000992 denotes ovaries
T2272 13706-13713 CL:0000023 denotes oocytes
T2273 13719-13729 GO_EXT:killing denotes eliminated
T2274 13748-13757 GO:0000239 denotes pachynema
T11039 15231-15232 SO_EXT:sequence_nullness_or_absence denotes −
T11040 15233-15239 PR_EXT:000016672 denotes Trip13
T11041 15242-15243 SO_EXT:normal_or_wild_type_or_present denotes +
T11042 15253-15258 UBERON:0000992 denotes ovary
T11043 15321-15325 PR_EXT:000031227 denotes Mei1
T11044 15326-15327 SO_EXT:sequence_nullness_or_absence denotes −
T11045 15328-15329 SO_EXT:sequence_nullness_or_absence denotes −
T11046 15330-15336 PR_EXT:000016672 denotes Trip13
T11047 15351-15356 UBERON:0000992 denotes ovary
T11048 15362-15366 PR_EXT:000013858 denotes Rec8
T11049 15371-15375 PR_EXT:000013858 denotes Rec8
T11050 15380-15386 PR_EXT:000016672 denotes Trip13
T11051 15389-15390 SO_EXT:normal_or_wild_type_or_present denotes +
T11052 15400-15405 UBERON:0000992 denotes ovary
T11053 15468-15472 PR_EXT:000013858 denotes Rec8
T11054 15477-15481 PR_EXT:000013858 denotes Rec8
T11055 15486-15492 PR_EXT:000016672 denotes Trip13
T2275 15539-15545 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2276 15546-15552 UBERON:0000473 denotes testes
T2277 15576-15583 GO:0007126 denotes meiotic
T2278 15584-15588 CL_GO_EXT:cell denotes cell
T2279 15622-15631 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2280 15632-15652 UBERON:0001343 denotes seminiferous tubules
T2281 15700-15720 UBERON:0001343 denotes seminiferous tubules
T2282 15741-15754 CL:0000017 denotes spermatocytes
T2283 15770-15779 GO:0000785 denotes chromatin
T2284 15798-15807 GO:0000239 denotes pachynema
T2285 15848-15861 GO:0007283 denotes spermatogenic
T2286 15911-15920 GO:0000239 denotes pachytene
T2287 15963-15973 GO_SO_EXT:chromosome denotes chromosome
T2288 16013-16018 UBERON:0007023 denotes adult
T2289 16019-16039 UBERON:0001343 denotes seminiferous tubules
T2290 16054-16061 GO:0007126 denotes meiotic
T2291 16062-16072 CL:0000018 denotes spermatids
T2292 16112-16122 UBERON:0001301 denotes epididymal
T2293 16123-16128 CL:0000019 denotes sperm
T2294 16144-16151 GO:0007126 denotes meiotic
T2295 16181-16186 NCBITaxon_EXT:yeast denotes yeast
T2296 16191-16201 NCBITaxon:6239 denotes C. elegans
T1631 9666-9672 PR_EXT:000016672 denotes Trip13
T4786 26813-26817 NCBITaxon:10088 denotes mice
T1632 9673-9679 SO_EXT:sequence_altered_entity_or_alteration_process denotes Mutant
T1633 9680-9684 NCBITaxon:10088 denotes Mice
T1634 9712-9718 PR_EXT:000016672 denotes TRIP13
T1635 9722-9729 NCBITaxon:40674 denotes mammals
T1636 9744-9748 NCBITaxon:10088 denotes mice
T1637 9756-9765 SO_EXT:gene_trap_or_trap_construct denotes gene trap
T1638 9776-9782 SO_EXT:0001023 denotes allele
T1639 9784-9790 PR_EXT:000016672 denotes Trip13
T1640 9824-9830 PR_EXT:000016672 denotes Trip13
T1641 9978-9984 PR_EXT:000016672 denotes Trip13
T1642 9985-9986 SO_EXT:normal_or_wild_type_or_present denotes +
T1643 9987-9988 SO_EXT:normal_or_wild_type_or_present denotes +
T1644 9994-10000 PR_EXT:000016672 denotes Trip13
T1645 10003-10004 SO_EXT:normal_or_wild_type_or_present denotes +
T1646 10013-10019 PR_EXT:000016672 denotes Trip13
T1647 10049-10053 NCBITaxon:10088 denotes mice
T1648 10059-10063 GO:0016265 denotes died
T1649 10069-10075 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1650 10149-10158 GO_EXT:fatality_or_lethality denotes lethality
T1651 10175-10181 PR_EXT:000016672 denotes Trip13
T1652 10187-10194 NCBITaxon:33208 denotes animals
T1653 10346-10351 UBERON:0002415 denotes tails
T1654 11173-11175 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T1655 11192-11198 PR_EXT:000016672 denotes Trip13
T1656 11201-11211 GO:0010467 denotes expression
T1657 11257-11264 GO:0008380 denotes spliced
T1658 11265-11276 SO_EXT:0000673 denotes transcripts
T1659 11280-11286 UBERON:0000473 denotes testes
T1660 11362-11371 SO_EXT:gene_trap_or_trap_construct denotes gene trap
T4784 26734-26739 PR_EXT:000015553 denotes Spo11
T4785 26747-26754 SO_EXT:sequence_altered_entity denotes mutants
T4787 26832-26836 PR_EXT:000031227 denotes Mei1
T4788 26840-26850 NCBITaxon:7742 denotes vertebrate
T4789 26860-26864 SO_EXT:0000704 denotes gene
T4790 26901-26911 GO_SO_EXT:chromosome denotes chromosome
T4791 26901-26920 GO:0007129 denotes chromosome synapsis
T2768 16840-16845 PR_EXT:000015865 denotes SYCP3
T2769 16876-16885 GO:0030849 denotes autosomes
T2770 16917-16918 _FRAGMENT denotes X
T2771 16925-16936 GO:0000805 denotes chromosomes
T2772 16923-16936 GO:0000806 denotes Y chromosomes
T2773 16925-16936 GO_SO_EXT:chromosome denotes chromosomes
T2774 16951-16959 GO:0007129 denotes synapsed
T2775 17022-17028 GO:0007567 denotes partum
T2776 17030-17036 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2777 17037-17050 CL:0000017 denotes spermatocytes
T2778 17062-17070 GO:0007129 denotes synaptic
T2779 17086-17094 GO:0007129 denotes synapsed
T2780 17095-17106 GO_SO_EXT:chromosome denotes chromosomes
T2781 17232-17237 GO:0007567 denotes natal
T2782 17238-17253 GO:0007283 denotes spermatogenesis
T2783 17367-17373 PR_EXT:000016672 denotes Trip13
T2784 17379-17392 CL:0000017 denotes spermatocytes
T2785 17405-17414 GO:0000239 denotes pachynema
T2786 17429-17431 GO:0000795 denotes SC
T2787 17451-17458 CL:0000023 denotes oocytes
T2788 17464-17474 GO_EXT:killing denotes eliminated
T2789 17486-17491 GO:0007567 denotes birth
T2790 17513-17516 CHEBI_SO_EXT:DNA denotes DNA
T2791 17513-17523 GO:0006281 denotes DNA repair
T2792 17524-17531 SO_EXT:sequence_altered_entity denotes mutants
T2793 17561-17569 GO:0006281 denotes repaired
T2794 17604-17611 GO:0007126 denotes meiotic
T2795 17623-17634 GO_EXT:killing denotes elimination
T2796 19520-19521 SO_EXT:wild_type_entity_or_quality denotes T
T2797 19524-19526 GO:0005634 denotes lu
T2798 19527-19528 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes i
T2799 19529-19531 GO:0007567 denotes at
T2800 19531-19532 GO:0007129 denotes e
T2801 19540-19542 CL:0000017 denotes se
T2802 19547-19548 GO:0030849 denotes e
T2803 19552-19553 GO_SO_EXT:chromosome denotes c
T2804 19567-19568 GO:0000239 denotes a
T2805 19570-19572 GO_PATO_EXT:biological_localization_process_or_quality denotes ze
T2806 19574-19581 GO:0007126 denotes meiotic
T2807 19582-19583 GO:0007126 denotes c
T2808 19583-19593 GO_SO_EXT:chromosome denotes hromosomes
T2809 19612-19619 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T2810 19643-19656 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T2811 19661-19669 GO:0007129 denotes synapsis
T2812 19671-19684 GO_SO_EXT:sequence_rearrangement_process denotes Recombination
T2813 19688-19694 PR_EXT:000016672 denotes Trip13
T2814 19700-19713 CL:0000017 denotes spermatocytes
T2815 19782-19791 GO:0000237 denotes leptonema
T2816 19845-19856 GO:0007126 denotes meiotically
T2817 19876-19881 PR_EXT:000013672 denotes RAD51
T2818 19889-19893 PR_EXT:000006536 denotes DMC1
T2819 19909-19936 GO:0005714 denotes early recombination nodules
T2820 19915-19928 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T2821 19938-19942 GO:0005714 denotes ERNs
T2822 19982-19988 PR_EXT:000016672 denotes Trip13
T2823 19994-20002 GO:0000238 denotes zygotene
T2824 20003-20016 CL:0000017 denotes spermatocytes
T2825 20045-20050 PR_EXT:000013672 denotes RAD51
T2826 20051-20059 GO:0042571 denotes antibody
T6555 38924-38929 NCBITaxon_EXT:yeast denotes yeast
T6556 38936-38941 SO_EXT:0000704 denotes genes
T6557 38953-38960 GO:0007067 denotes mitotic
T6558 38980-38985 PR_EXT:P32641 denotes RAD24
T6559 39021-39030 GO_EXT:fatality_or_lethality denotes lethality
T6560 39044-39053 NCBITaxon:40674 denotes mammalian
T6561 39054-39074 GO:0051598 denotes pachytene checkpoint
T6562 39091-39100 SO_EXT:0000855 denotes orthologs
T6563 39127-39136 NCBITaxon:1 denotes organisms
T6564 39145-39150 NCBITaxon_EXT:yeast denotes yeast
R2 T66 T65 _lexicallyChainedTo Synapsis,Meiotic
R877 T1388 T1387 _lexicallyChainedTo related,evolutionarily
R878 T1397 T1396 _lexicallyChainedTo tissues,embryonic
R6032 T8902 T8901 _lexicallyChainedTo of,Development
R6033 T8903 T8902 _lexicallyChainedTo antibodies,of
R249 T638 T637 _lexicallyChainedTo checkpoint,pachytene
R250 T666 T665 _lexicallyChainedTo DSBs,repair of
R1473 T2301 T2300 _lexicallyChainedTo development,spore
R1738 T2753 T2752 _lexicallyChainedTo elements,axial
R1739 T2771 T2770 _lexicallyChainedTo chromosomes,X
R1740 T2889 T2888 _lexicallyChainedTo chromosomes,regions of
R1741 T2925 T2924 _lexicallyChainedTo chromatin,silencing of
R2646 T4105 T4104 _lexicallyChainedTo SC,degradation of
R3997 T6234 T6233 _lexicallyChainedTo repair,recombinational
R3998 T6289 T6288 _lexicallyChainedTo recombination,CO
R3999 T6356 T6355 _lexicallyChainedTo complexes,disassembly of
R4000 T6371 T6370 _lexicallyChainedTo complex disassembly,protein
R4001 T6411 T6410 _lexicallyChainedTo checkpoint,DNA damage
R4002 T6444 T6443 _lexicallyChainedTo body,XY
R4003 T6444 T6445 _lexicallyChainedTo body,sex
R4004 T6533 T6532 _lexicallyChainedTo repair,recombinational
R6259 T9319 T9318 _lexicallyChainedTo 594,Alexa Fluor