PMC:1920263 / 1424-4358 JSON TXT

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test2

Id	Subject	Object	Predicate	Lexical cue
T751	186-194	Protein	denotes	APOBEC3A
T752	196-197	Protein	denotes	B
T753	199-200	Protein	denotes	C
T754	202-204	Protein	denotes	DE
T755	206-207	Protein	denotes	F
T756	209-210	Protein	denotes	G
T757	212-213	Protein	denotes	H
T758	302-310	Protein	denotes	APOBEC3G
T759	312-315	Protein	denotes	A3G
T760	445-455	Negative_regulation	denotes	inhibition
T761	459-484	Protein	denotes	virion infectivity factor
T762	486-489	Protein	denotes	Vif
T763	491-498	Negative_regulation	denotes	deleted
T764	579-582	Protein	denotes	A3G
T765	604-609	Protein	denotes	1Δvif
T766	898-901	Protein	denotes	A3G
T767	1012-1015	Protein	denotes	A3G
T768	1260-1263	Protein	denotes	A3G
T769	1382-1385	Protein	denotes	A3G
T770	1523-1531	Protein	denotes	APOBEC3F
T771	1533-1536	Protein	denotes	A3F
T772	1579-1582	Protein	denotes	A3G
T773	1592-1595	Protein	denotes	A3F
T774	1622-1627	Protein	denotes	1Δvif
T775	1768-1771	Protein	denotes	A3F
T776	1816-1823	Gene_expression	denotes	express
T777	1824-1827	Protein	denotes	A3G
T778	1844-1848	Positive_regulation	denotes	form
T779	1849-1864	Binding	denotes	heteromultimers
T780	1870-1873	Protein	denotes	A3G
T781	1912-1931	Entity	denotes	mRNA processing (P)
T782	2039-2042	Protein	denotes	A3G
T783	2064-2073	Gene_expression	denotes	expressed
T784	2247-2258	Positive_regulation	denotes	upregulates
T785	2259-2262	Protein	denotes	A3G
T786	2347-2350	Protein	denotes	A3G
T787	2430-2433	Protein	denotes	A3G
T788	2518-2521	Protein	denotes	A3G
T789	2617-2620	Protein	denotes	A3G
T790	2763-2772	Positive_regulation	denotes	inducible
T791	2801-2811	Protein	denotes	interferon
T792	2831-2840	Regulation	denotes	dependent
T793	2846-2849	Entity	denotes	GC-
T794	2863-2873	Binding	denotes	recognized
T795	2877-2903	Protein	denotes	Sp (specificity protein) 1
T796	2908-2911	Protein	denotes	Sp3
R618	T759	T758	equivalentTo	A3G,APOBEC3G
R619	T761	T760	themeOf	virion infectivity factor,inhibition
R620	T761	T763	themeOf	virion infectivity factor,deleted
R621	T762	T761	equivalentTo	Vif,virion infectivity factor
R622	T771	T770	equivalentTo	A3F,APOBEC3F
R623	T775	T776	themeOf	A3F,express
R624	T777	T776	themeOf	A3G,express
R625	T780	T779	themeOf	A3G,heteromultimers
R626	T782	T783	themeOf	A3G,expressed
R627	T785	T784	themeOf	A3G,upregulates
R628	T790	T792	themeOf	inducible,dependent
R629	T791	T790	causeOf	interferon,inducible
R630	T794	T792	causeOf	recognized,dependent
R631	T795	T792	causeOf	Sp (specificity protein) 1,dependent
R632	T795	T794	causeOf	Sp (specificity protein) 1,recognized
R633	T796	T794	causeOf	Sp3,recognized
R634	T796	T792	causeOf	Sp3,dependent

ICD10

Id	Subject	Object	Predicate	Lexical cue
T1983	505-521	http://purl.bioontology.org/ontology/ICD10/D84.9	denotes	immunodeficiency

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T1984	459-465	http://purl.obolibrary.org/obo/GO_0019012	denotes	virion
T1985	568-573	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T1986	2079-2084	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T1987	2241-2246	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T1988	2480-2485	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T1989	2701-2706	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T1990	833-845	http://purl.obolibrary.org/obo/GO_0019015	denotes	viral genome
T1991	1929-1938	http://purl.obolibrary.org/obo/GO_0000932	denotes	P) bodies
T1992	1929-1938	http://purl.obolibrary.org/obo/GO_0010494	denotes	P) bodies
T1993	2741-2745	http://purl.obolibrary.org/obo/GO_0019013	denotes	core

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T866	393-401	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T867	779-787	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T868	691-712	http://purl.obolibrary.org/obo/GO_0001171	denotes	reverse transcription
T869	699-712	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T870	2681-2694	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T871	2912-2925	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T872	734-745	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T873	1981-1992	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T874	1891-1908	http://purl.obolibrary.org/obo/GO_0008104	denotes	proteins localize
T875	1900-1908	http://purl.obolibrary.org/obo/GO_0051179	denotes	localize
T876	1912-1927	http://purl.obolibrary.org/obo/GO_0006397	denotes	mRNA processing
T877	1997-2004	http://purl.obolibrary.org/obo/GO_0051235	denotes	storage
T878	2012-2023	http://purl.obolibrary.org/obo/GO_0006412	denotes	translating
T879	2158-2168	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T880	2464-2474	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T797	1803-1810	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissues

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T1445	13-16	DT	denotes	The
T1446	17-25	RB	denotes	recently
T1447	26-36	VBN	denotes	discovered
T1448	37-44	NNP	denotes	APOBEC3
T1449	45-51	NN	denotes	family
T1450	52-54	IN	denotes	of
T1451	55-63	NN	denotes	cytidine
T1452	64-74	NNS	denotes	deaminases
T1453	75-77	VBZ	denotes	is
T1454	78-88	VBN	denotes	considered
T1455	89-91	TO	denotes	to
T1456	92-96	VB	denotes	play
T1457	97-99	DT	denotes	an
T1458	100-109	JJ	denotes	important
T1459	110-114	NN	denotes	role
T1460	115-117	IN	denotes	in
T1461	118-127	JJ	denotes	antiviral
T1462	128-137	JJ	denotes	intrinsic
T1463	138-146	NN	denotes	immunity
T1464	147-148	-LRB-	denotes	(
T1465	148-151	CD	denotes	1,2
T1466	151-152	-RRB-	denotes	)
T1467	152-153	.	denotes	.
T1468	154-156	IN	denotes	In
T1469	157-165	NNS	denotes	primates
T1470	165-166	,	denotes	,
T1471	167-170	DT	denotes	the
T1472	171-176	CD	denotes	seven
T1473	177-185	NNS	denotes	paralogs
T1474	186-194	NNP	denotes	APOBEC3A
T1475	194-195	,	denotes	,
T1476	196-197	NNP	denotes	B
T1477	197-198	,	denotes	,
T1478	199-200	NNP	denotes	C
T1479	200-201	,	denotes	,
T1480	202-204	NNP	denotes	DE
T1481	204-205	,	denotes	,
T1482	206-207	NN	denotes	F
T1483	207-208	,	denotes	,
T1484	209-210	NNP	denotes	G
T1485	210-211	,	denotes	,
T1486	212-213	NNP	denotes	H
T1487	214-215	-LRB-	denotes	(
T1488	215-220	NNP	denotes	A3A-H
T1489	220-221	-RRB-	denotes	)
T1490	222-226	VBP	denotes	have
T1491	227-231	VBN	denotes	been
T1492	232-241	VBN	denotes	described
T1493	242-243	-LRB-	denotes	(
T1494	243-244	LS	denotes	3
T1495	244-245	-RRB-	denotes	)
T1496	245-246	,	denotes	,
T1497	247-250	CC	denotes	and
T1498	251-255	PRP	denotes	they
T1499	256-262	VBP	denotes	appear
T1500	263-265	TO	denotes	to
T1501	266-273	VB	denotes	fulfill
T1502	274-284	JJ	denotes	individual
T1503	285-294	NNS	denotes	functions
T1504	294-295	.	denotes	.
T1505	296-301	NNP	denotes	Human
T1506	302-310	NNP	denotes	APOBEC3G
T1507	311-312	-LRB-	denotes	(
T1508	312-315	NNP	denotes	A3G
T1509	315-316	-RRB-	denotes	)
T1510	316-317	,	denotes	,
T1511	318-321	DT	denotes	the
T1512	322-326	RBS	denotes	most
T1513	327-336	JJ	denotes	prominent
T1514	337-343	NN	denotes	member
T1515	344-346	IN	denotes	of
T1516	347-350	DT	denotes	the
T1517	351-358	NNP	denotes	APOBEC3
T1518	359-365	NN	denotes	family
T1519	366-369	VBZ	denotes	has
T1520	370-374	VBN	denotes	been
T1521	375-385	VBN	denotes	identified
T1522	386-388	IN	denotes	as
T1523	389-392	DT	denotes	the
T1524	393-401	JJ	denotes	cellular
T1525	402-413	NN	denotes	restriction
T1526	414-420	NN	denotes	factor
T1527	421-425	WDT	denotes	that
T1528	426-428	VBZ	denotes	is
T1529	429-440	JJ	denotes	responsible
T1530	441-444	IN	denotes	for
T1531	445-455	NN	denotes	inhibition
T1532	456-458	IN	denotes	of
T1533	459-465	NN	denotes	virion
T1534	466-477	NN	denotes	infectivity
T1535	478-484	NN	denotes	factor
T1536	485-486	-LRB-	denotes	(
T1537	486-489	NNP	denotes	Vif
T1538	489-490	-RRB-	denotes	)
T1539	490-491	:	denotes	-
T1540	491-498	VBN	denotes	deleted
T1541	499-504	JJ	denotes	human
T1542	505-521	NN	denotes	immunodeficiency
T1543	522-529	JJ	denotes	virus-1
T1544	530-531	-LRB-	denotes	(
T1545	531-536	NNP	denotes	HIV-1
T1546	536-537	-RRB-	denotes	)
T1547	538-549	NN	denotes	replication
T1548	550-552	IN	denotes	in
T1549	553-567	JJ	denotes	non-permissive
T1550	568-573	NNS	denotes	cells
T1551	574-575	-LRB-	denotes	(
T1552	575-576	CD	denotes	4
T1553	576-577	-RRB-	denotes	)
T1554	577-578	.	denotes	.
T1555	579-582	CD	denotes	A3G
T1556	583-585	VBZ	denotes	is
T1557	586-594	VBN	denotes	packaged
T1558	595-599	IN	denotes	into
T1559	600-609	JJ	denotes	HIV-1Δvif
T1560	610-619	NNS	denotes	particles
T1561	620-623	CC	denotes	and
T1562	624-630	VBZ	denotes	causes
T1563	631-637	NNP	denotes	C-to-U
T1564	638-650	NNS	denotes	deaminations
T1565	651-653	IN	denotes	on
T1566	654-657	DT	denotes	the
T1567	658-673	JJ	denotes	single-stranded
T1568	674-679	JJ	denotes	viral
T1569	680-683	NN	denotes	DNA
T1570	684-690	IN	denotes	during
T1571	691-698	JJ	denotes	reverse
T1572	699-712	NN	denotes	transcription
T1573	713-714	-LRB-	denotes	(
T1574	714-715	CD	denotes	5
T1575	716-717	CD	denotes	8
T1576	717-718	-RRB-	denotes	)
T1577	718-719	.	denotes	.
T1578	720-724	DT	denotes	This
T1579	725-730	VBZ	denotes	leads
T1580	731-733	TO	denotes	to
T1581	734-745	NN	denotes	degradation
T1582	746-748	IN	denotes	of
T1583	749-752	DT	denotes	the
T1584	753-771	JJ	denotes	uracile-containing
T1585	772-775	NN	denotes	DNA
T1586	776-778	IN	denotes	by
T1587	779-787	JJ	denotes	cellular
T1588	788-794	NN	denotes	repair
T1589	795-805	NNS	denotes	mechanisms
T1590	806-808	CC	denotes	or
T1591	809-811	TO	denotes	to
T1592	812-825	NN	denotes	hypermutation
T1593	826-828	IN	denotes	of
T1594	829-832	DT	denotes	the
T1595	833-838	JJ	denotes	viral
T1596	839-845	NN	denotes	genome
T1597	846-847	-LRB-	denotes	(
T1598	847-850	CD	denotes	5,6
T1599	850-851	-RRB-	denotes	)
T1600	851-852	.	denotes	.
T1601	853-855	IN	denotes	As
T1602	856-857	DT	denotes	a
T1603	858-864	NN	denotes	result
T1604	864-865	,	denotes	,
T1605	866-870	RB	denotes	only
T1606	871-872	DT	denotes	a
T1607	873-881	JJ	denotes	marginal
T1608	882-890	NN	denotes	fraction
T1609	891-893	IN	denotes	of
T1610	894-897	DT	denotes	the
T1611	898-912	JJ	denotes	A3G-containing
T1612	913-918	NN	denotes	HIV-1
T1613	919-928	NNS	denotes	particles
T1614	929-931	VBZ	denotes	is
T1615	932-936	JJ	denotes	able
T1616	937-939	TO	denotes	to
T1617	940-948	VB	denotes	complete
T1618	949-952	DT	denotes	the
T1619	953-964	NN	denotes	replication
T1620	965-970	NN	denotes	cycle
T1621	970-971	.	denotes	.
T1622	972-974	IN	denotes	In
T1623	975-983	NN	denotes	addition
T1624	984-986	TO	denotes	to
T1625	987-990	DT	denotes	the
T1626	991-1001	NN	denotes	inhibition
T1627	1002-1004	IN	denotes	of
T1628	1005-1010	NNP	denotes	HIV-1
T1629	1010-1011	,	denotes	,
T1630	1012-1015	NNP	denotes	A3G
T1631	1016-1025	VBZ	denotes	restricts
T1632	1026-1037	NN	denotes	replication
T1633	1038-1040	IN	denotes	of
T1634	1041-1046	JJ	denotes	other
T1635	1047-1059	NNS	denotes	lentiviruses
T1636	1059-1060	,	denotes	,
T1637	1061-1078	NNS	denotes	gammaretroviruses
T1638	1078-1079	,	denotes	,
T1639	1080-1097	NNS	denotes	deltaretroviruses
T1640	1097-1098	,	denotes	,
T1641	1099-1111	NNS	denotes	spumaviruses
T1642	1111-1112	,	denotes	,
T1643	1113-1133	NN	denotes	long-terminal-repeat
T1644	1134-1135	-LRB-	denotes	(
T1645	1135-1138	NNP	denotes	LTR
T1646	1138-1139	-RRB-	denotes	)
T1647	1139-1140	:	denotes	-
T1648	1140-1156	NNS	denotes	retrotransposons
T1649	1156-1157	,	denotes	,
T1650	1158-1177	NNS	denotes	orthohepadnaviruses
T1651	1178-1181	CC	denotes	and
T1652	1182-1199	NNS	denotes	avihepadnaviruses
T1653	1200-1201	-LRB-	denotes	(
T1654	1201-1202	CD	denotes	9
T1655	1203-1205	CD	denotes	21
T1656	1205-1206	-RRB-	denotes	)
T1657	1206-1207	.	denotes	.
T1658	1208-1221	RB	denotes	Interestingly
T1659	1221-1222	,	denotes	,
T1660	1223-1234	NN	denotes	deamination
T1661	1235-1240	VBZ	denotes	seems
T1662	1241-1244	RB	denotes	not
T1663	1245-1247	TO	denotes	to
T1664	1248-1250	VB	denotes	be
T1665	1251-1254	DT	denotes	the
T1666	1255-1259	JJ	denotes	only
T1667	1260-1272	JJ	denotes	A3G-mediated
T1668	1273-1282	JJ	denotes	antiviral
T1669	1283-1292	NN	denotes	mechanism
T1670	1292-1293	:	denotes	;
T1671	1294-1296	IN	denotes	in
T1672	1297-1300	DT	denotes	the
T1673	1301-1305	NN	denotes	case
T1674	1306-1308	IN	denotes	of
T1675	1309-1318	NNP	denotes	hepatitis
T1676	1319-1320	NNP	denotes	B
T1677	1321-1326	NN	denotes	virus
T1678	1327-1328	-LRB-	denotes	(
T1679	1328-1331	NNP	denotes	HBV
T1680	1331-1332	-RRB-	denotes	)
T1681	1333-1336	CC	denotes	and
T1682	1337-1342	JJ	denotes	human
T1683	1343-1344	NNP	denotes	T
T1684	1345-1349	NN	denotes	cell
T1685	1350-1358	NN	denotes	leukemia
T1686	1359-1364	NN	denotes	virus
T1687	1365-1369	NN	denotes	type
T1688	1370-1371	CD	denotes	1
T1689	1372-1373	-LRB-	denotes	(
T1690	1373-1379	NN	denotes	HTLV-1
T1691	1379-1380	-RRB-	denotes	)
T1692	1380-1381	,	denotes	,
T1693	1382-1385	NNP	denotes	A3G
T1694	1386-1389	VBD	denotes	was
T1695	1390-1395	VBN	denotes	shown
T1696	1396-1398	TO	denotes	to
T1697	1399-1407	VB	denotes	restrict
T1698	1408-1413	NN	denotes	virus
T1699	1414-1425	NN	denotes	replication
T1700	1426-1428	IN	denotes	by
T1701	1429-1452	JJ	denotes	deamination-independent
T1702	1453-1463	NNS	denotes	mechanisms
T1703	1464-1465	-LRB-	denotes	(
T1704	1465-1467	CD	denotes	12
T1705	1467-1468	,	denotes	,
T1706	1469-1471	CD	denotes	13
T1707	1471-1472	,	denotes	,
T1708	1473-1475	CD	denotes	19
T1709	1475-1476	,	denotes	,
T1710	1477-1479	CD	denotes	22
T1711	1480-1482	CD	denotes	25
T1712	1482-1483	-RRB-	denotes	)
T1713	1483-1484	.	denotes	.
T1714	1485-1492	DT	denotes	Another
T1715	1493-1499	NN	denotes	member
T1716	1500-1502	IN	denotes	of
T1717	1503-1506	DT	denotes	the
T1718	1507-1514	NNP	denotes	APOBEC3
T1719	1515-1521	NN	denotes	family
T1720	1521-1522	,	denotes	,
T1721	1523-1531	NNP	denotes	APOBEC3F
T1722	1532-1533	-LRB-	denotes	(
T1723	1533-1536	NNP	denotes	A3F
T1724	1536-1537	-RRB-	denotes	)
T1725	1537-1538	,	denotes	,
T1726	1539-1546	VBZ	denotes	appears
T1727	1547-1549	TO	denotes	to
T1728	1550-1554	VB	denotes	have
T1729	1555-1562	JJ	denotes	similar
T1730	1563-1573	NNS	denotes	activities
T1731	1574-1578	IN	denotes	like
T1732	1579-1582	NNP	denotes	A3G
T1733	1583-1584	-LRB-	denotes	(
T1734	1584-1589	CD	denotes	26,27
T1735	1589-1590	-RRB-	denotes	)
T1736	1590-1591	.	denotes	.
T1737	1592-1595	CD	denotes	A3F
T1738	1596-1598	VBZ	denotes	is
T1739	1599-1603	RB	denotes	also
T1740	1604-1612	VBN	denotes	packaged
T1741	1613-1617	IN	denotes	into
T1742	1618-1627	JJ	denotes	HIV-1Δvif
T1743	1628-1637	NNS	denotes	particles
T1744	1638-1641	CC	denotes	and
T1745	1642-1649	VBZ	denotes	induces
T1746	1650-1657	JJ	denotes	similar
T1747	1658-1664	NNP	denotes	C-to-U
T1748	1665-1677	NNS	denotes	deaminations
T1749	1677-1678	,	denotes	,
T1750	1679-1687	IN	denotes	although
T1751	1688-1691	DT	denotes	the
T1752	1692-1700	NNS	denotes	proteins
T1753	1701-1707	VBP	denotes	differ
T1754	1708-1710	IN	denotes	in
T1755	1711-1716	PRP$	denotes	their
T1756	1717-1723	NN	denotes	target
T1757	1724-1733	NNS	denotes	sequences
T1758	1734-1745	NN	denotes	specificity
T1759	1746-1747	-LRB-	denotes	(
T1760	1747-1752	CD	denotes	26,28
T1761	1752-1753	-RRB-	denotes	)
T1762	1753-1754	.	denotes	.
T1763	1755-1766	RB	denotes	Furthermore
T1764	1766-1767	,	denotes	,
T1765	1768-1771	NNP	denotes	A3F
T1766	1772-1780	NNS	denotes	proteins
T1767	1781-1785	VBD	denotes	were
T1768	1786-1794	VBN	denotes	detected
T1769	1795-1797	IN	denotes	in
T1770	1798-1802	JJ	denotes	many
T1771	1803-1810	NNS	denotes	tissues
T1772	1811-1815	WDT	denotes	that
T1773	1816-1823	VBP	denotes	express
T1774	1824-1827	NNP	denotes	A3G
T1775	1828-1831	CC	denotes	and
T1776	1832-1835	VBP	denotes	are
T1777	1836-1840	JJ	denotes	able
T1778	1841-1843	TO	denotes	to
T1779	1844-1848	VB	denotes	form
T1780	1849-1864	NNS	denotes	heteromultimers
T1781	1865-1869	IN	denotes	with
T1782	1870-1873	NNP	denotes	A3G
T1783	1874-1875	-LRB-	denotes	(
T1784	1875-1883	CD	denotes	26,29,30
T1785	1883-1884	-RRB-	denotes	)
T1786	1884-1885	.	denotes	.
T1787	1886-1890	DT	denotes	Both
T1788	1891-1899	NNS	denotes	proteins
T1789	1900-1908	VBP	denotes	localize
T1790	1909-1911	TO	denotes	to
T1791	1912-1916	NNP	denotes	mRNA
T1792	1917-1927	NN	denotes	processing
T1793	1928-1929	-LRB-	denotes	(
T1794	1929-1930	NNP	denotes	P
T1795	1930-1931	-RRB-	denotes	)
T1796	1932-1938	NNS	denotes	bodies
T1797	1938-1939	,	denotes	,
T1798	1940-1951	JJ	denotes	cytoplasmic
T1799	1952-1964	NNS	denotes	compartments
T1800	1965-1973	VBN	denotes	involved
T1801	1974-1976	IN	denotes	in
T1802	1977-1980	DT	denotes	the
T1803	1981-1992	NN	denotes	degradation
T1804	1993-1996	CC	denotes	and
T1805	1997-2004	NN	denotes	storage
T1806	2005-2007	IN	denotes	of
T1807	2008-2023	JJ	denotes	non-translating
T1808	2024-2029	NNS	denotes	mRNAs
T1809	2030-2031	-LRB-	denotes	(
T1810	2031-2036	CD	denotes	30,31
T1811	2036-2037	-RRB-	denotes	)
T1812	2037-2038	.	denotes	.
T1813	2039-2042	CD	denotes	A3G
T1814	2043-2046	VBZ	denotes	has
T1815	2047-2051	VBN	denotes	been
T1816	2052-2057	VBN	denotes	shown
T1817	2058-2060	TO	denotes	to
T1818	2061-2063	VB	denotes	be
T1819	2064-2073	VBN	denotes	expressed
T1820	2074-2076	IN	denotes	in
T1821	2077-2078	NNP	denotes	T
T1822	2079-2084	NNS	denotes	cells
T1823	2084-2085	,	denotes	,
T1824	2086-2087	DT	denotes	a
T1825	2088-2096	JJ	denotes	relevant
T1826	2097-2101	NN	denotes	cell
T1827	2102-2108	NN	denotes	target
T1828	2109-2112	IN	denotes	for
T1829	2113-2118	NNP	denotes	HIV-1
T1830	2119-2121	IN	denotes	in
T1831	2122-2126	NN	denotes	vivo
T1832	2126-2127	,	denotes	,
T1833	2128-2131	CC	denotes	but
T1834	2132-2138	RB	denotes	little
T1835	2139-2141	VBZ	denotes	is
T1836	2142-2147	VBN	denotes	known
T1837	2148-2153	IN	denotes	about
T1838	2154-2157	PRP$	denotes	its
T1839	2158-2168	NN	denotes	regulation
T1840	2169-2170	-LRB-	denotes	(
T1841	2170-2177	CD	denotes	4,29,32
T1842	2177-2178	-RRB-	denotes	)
T1843	2178-2179	.	denotes	.
T1844	2180-2185	EX	denotes	There
T1845	2186-2188	VBZ	denotes	is
T1846	2189-2190	DT	denotes	a
T1847	2191-2197	NN	denotes	report
T1848	2198-2208	VBG	denotes	describing
T1849	2209-2213	IN	denotes	that
T1850	2214-2223	JJ	denotes	mitogenic
T1851	2224-2235	NN	denotes	stimulation
T1852	2236-2238	IN	denotes	of
T1853	2239-2240	NNP	denotes	T
T1854	2241-2246	NNS	denotes	cells
T1855	2247-2258	VBZ	denotes	upregulates
T1856	2259-2262	NNP	denotes	A3G
T1857	2263-2267	NNP	denotes	mRNA
T1858	2268-2274	NNS	denotes	levels
T1859	2274-2275	,	denotes	,
T1860	2276-2279	CC	denotes	but
T1861	2280-2284	DT	denotes	this
T1862	2285-2288	VBD	denotes	was
T1863	2289-2292	RB	denotes	not
T1864	2293-2301	VBN	denotes	analyzed
T1865	2302-2304	IN	denotes	on
T1866	2305-2308	DT	denotes	the
T1867	2309-2324	JJ	denotes	transcriptional
T1868	2325-2330	NN	denotes	level
T1869	2331-2332	-LRB-	denotes	(
T1870	2332-2334	CD	denotes	33
T1871	2334-2335	-RRB-	denotes	)
T1872	2335-2336	.	denotes	.
T1873	2337-2342	IN	denotes	Since
T1874	2343-2346	DT	denotes	the
T1875	2347-2350	NNP	denotes	A3G
T1876	2351-2359	NN	denotes	promoter
T1877	2360-2363	VBZ	denotes	has
T1878	2364-2367	RB	denotes	not
T1879	2368-2372	VBN	denotes	been
T1880	2373-2387	RB	denotes	systematically
T1881	2388-2396	VBN	denotes	analyzed
T1882	2397-2399	RB	denotes	so
T1883	2400-2403	RB	denotes	far
T1884	2403-2404	,	denotes	,
T1885	2405-2408	PRP$	denotes	our
T1886	2409-2412	NN	denotes	aim
T1887	2413-2416	VBD	denotes	was
T1888	2417-2419	TO	denotes	to
T1889	2420-2425	VB	denotes	clone
T1890	2426-2429	DT	denotes	the
T1891	2430-2433	NNP	denotes	A3G
T1892	2434-2442	NN	denotes	promoter
T1893	2443-2446	CC	denotes	and
T1894	2447-2459	VB	denotes	characterize
T1895	2460-2463	PRP$	denotes	its
T1896	2464-2474	NN	denotes	regulation
T1897	2475-2477	IN	denotes	in
T1898	2478-2479	NNP	denotes	T
T1899	2480-2485	NNS	denotes	cells
T1900	2485-2486	.	denotes	.
T1901	2487-2489	IN	denotes	In
T1902	2490-2493	PRP$	denotes	our
T1903	2494-2499	NN	denotes	study
T1904	2499-2500	,	denotes	,
T1905	2501-2503	PRP	denotes	we
T1906	2504-2512	VBD	denotes	observed
T1907	2513-2517	IN	denotes	that
T1908	2518-2521	NNP	denotes	A3G
T1909	2522-2526	VBZ	denotes	uses
T1910	2527-2535	JJ	denotes	multiple
T1911	2536-2551	JJ	denotes	transcriptional
T1912	2552-2557	NN	denotes	start
T1913	2558-2563	NNS	denotes	sites
T1914	2564-2565	-LRB-	denotes	(
T1915	2565-2568	NNP	denotes	TSS
T1916	2568-2569	-RRB-	denotes	)
T1917	2569-2570	.	denotes	.
T1918	2571-2573	IN	denotes	By
T1919	2574-2584	VBG	denotes	generating
T1920	2585-2586	DT	denotes	a
T1921	2587-2593	NN	denotes	series
T1922	2594-2596	IN	denotes	of
T1923	2597-2598	CD	denotes	5
T1924	2598-2599	CD	denotes	′
T1925	2600-2609	NNS	denotes	deletions
T1926	2610-2612	IN	denotes	of
T1927	2613-2616	DT	denotes	the
T1928	2617-2620	NNP	denotes	A3G
T1929	2621-2629	NN	denotes	promoter
T1930	2629-2630	,	denotes	,
T1931	2631-2633	PRP	denotes	we
T1932	2634-2644	VBD	denotes	identified
T1933	2645-2646	DT	denotes	a
T1934	2647-2650	CD	denotes	180
T1935	2651-2653	NN	denotes	bp
T1936	2654-2660	NN	denotes	region
T1937	2661-2665	WDT	denotes	that
T1938	2666-2674	VBD	denotes	mediated
T1939	2675-2680	JJ	denotes	basal
T1940	2681-2694	NN	denotes	transcription
T1941	2694-2695	.	denotes	.
T1942	2696-2698	IN	denotes	In
T1943	2699-2700	NNP	denotes	T
T1944	2701-2706	NNS	denotes	cells
T1945	2706-2707	,	denotes	,
T1946	2708-2723	JJ	denotes	transcriptional
T1947	2724-2732	NN	denotes	activity
T1948	2733-2735	IN	denotes	of
T1949	2736-2740	DT	denotes	this
T1950	2741-2745	NN	denotes	core
T1951	2746-2754	NN	denotes	promoter
T1952	2755-2758	VBD	denotes	was
T1953	2759-2762	RB	denotes	not
T1954	2763-2772	JJ	denotes	inducible
T1955	2773-2775	IN	denotes	by
T1956	2776-2785	JJ	denotes	mitogenic
T1957	2786-2797	NN	denotes	stimulation
T1958	2798-2800	CC	denotes	or
T1959	2801-2811	NN	denotes	interferon
T1960	2812-2821	NN	denotes	treatment
T1961	2821-2822	,	denotes	,
T1962	2823-2826	CC	denotes	but
T1963	2827-2830	VBD	denotes	was
T1964	2831-2840	JJ	denotes	dependent
T1965	2841-2843	IN	denotes	on
T1966	2844-2845	DT	denotes	a
T1967	2846-2852	JJ	denotes	GC-box
T1968	2853-2858	WDT	denotes	which
T1969	2859-2862	VBD	denotes	was
T1970	2863-2873	VBN	denotes	recognized
T1971	2874-2876	IN	denotes	by
T1972	2877-2879	NNP	denotes	Sp
T1973	2880-2881	-LRB-	denotes	(
T1974	2881-2892	NN	denotes	specificity
T1975	2893-2900	NN	denotes	protein
T1976	2900-2901	-RRB-	denotes	)
T1977	2902-2903	CD	denotes	1
T1978	2904-2907	CC	denotes	and
T1979	2908-2911	JJ	denotes	Sp3
T1980	2912-2925	NN	denotes	transcription
T1981	2926-2933	NNS	denotes	factors
T1982	2933-2934	.	denotes	.
R1194	T1445	T1449	det	The,family
R1195	T1446	T1447	advmod	recently,discovered
R1196	T1447	T1449	amod	discovered,family
R1197	T1448	T1449	compound	APOBEC3,family
R1198	T1449	T1454	nsubjpass	family,considered
R1199	T1450	T1449	prep	of,family
R1200	T1451	T1452	compound	cytidine,deaminases
R1201	T1452	T1450	pobj	deaminases,of
R1202	T1453	T1454	auxpass	is,considered
R1203	T1454	T1454	ROOT	considered,considered
R1204	T1455	T1456	aux	to,play
R1205	T1456	T1454	xcomp	play,considered
R1206	T1457	T1459	det	an,role
R1207	T1458	T1459	amod	important,role
R1208	T1459	T1456	dobj	role,play
R1209	T1460	T1456	prep	in,play
R1210	T1461	T1463	amod	antiviral,immunity
R1211	T1462	T1463	amod	intrinsic,immunity
R1212	T1463	T1460	pobj	immunity,in
R1213	T1464	T1463	punct	(,immunity
R1214	T1465	T1463	appos	"1,2",immunity
R1215	T1466	T1463	punct	),immunity
R1216	T1467	T1454	punct	.,considered
R1217	T1468	T1492	prep	In,described
R1218	T1469	T1468	pobj	primates,In
R1219	T1470	T1492	punct	",",described
R1220	T1471	T1473	det	the,paralogs
R1221	T1472	T1473	nummod	seven,paralogs
R1222	T1473	T1492	nsubjpass	paralogs,described
R1223	T1474	T1473	conj	APOBEC3A,paralogs
R1224	T1475	T1474	punct	",",APOBEC3A
R1225	T1476	T1474	conj	B,APOBEC3A
R1226	T1477	T1476	punct	",",B
R1227	T1478	T1476	conj	C,B
R1228	T1479	T1478	punct	",",C
R1229	T1480	T1478	conj	DE,C
R1230	T1481	T1480	punct	",",DE
R1231	T1482	T1478	conj	F,C
R1232	T1483	T1482	punct	",",F
R1233	T1484	T1482	conj	G,F
R1234	T1485	T1484	punct	",",G
R1235	T1486	T1492	nsubjpass	H,described
R1236	T1487	T1488	punct	(,A3A-H
R1237	T1488	T1486	appos	A3A-H,H
R1238	T1489	T1486	punct	),H
R1239	T1490	T1492	aux	have,described
R1240	T1491	T1492	auxpass	been,described
R1241	T1492	T1492	ROOT	described,described
R1242	T1493	T1494	punct	(,3
R1243	T1494	T1492	parataxis	3,described
R1244	T1495	T1494	punct	),3
R1245	T1496	T1492	punct	",",described
R1246	T1497	T1492	cc	and,described
R1247	T1498	T1499	nsubj	they,appear
R1248	T1499	T1492	conj	appear,described
R1249	T1500	T1501	aux	to,fulfill
R1250	T1501	T1499	xcomp	fulfill,appear
R1251	T1502	T1503	amod	individual,functions
R1252	T1503	T1501	dobj	functions,fulfill
R1253	T1504	T1499	punct	.,appear
R1254	T1505	T1506	compound	Human,APOBEC3G
R1255	T1506	T1521	nsubjpass	APOBEC3G,identified
R1256	T1507	T1508	punct	(,A3G
R1257	T1508	T1506	appos	A3G,APOBEC3G
R1258	T1509	T1506	punct	),APOBEC3G
R1259	T1510	T1506	punct	",",APOBEC3G
R1260	T1511	T1514	det	the,member
R1261	T1512	T1513	advmod	most,prominent
R1262	T1513	T1514	amod	prominent,member
R1263	T1514	T1506	appos	member,APOBEC3G
R1264	T1515	T1514	prep	of,member
R1265	T1516	T1518	det	the,family
R1266	T1517	T1518	compound	APOBEC3,family
R1267	T1518	T1515	pobj	family,of
R1268	T1519	T1521	aux	has,identified
R1269	T1520	T1521	auxpass	been,identified
R1270	T1521	T1521	ROOT	identified,identified
R1271	T1522	T1521	prep	as,identified
R1272	T1523	T1526	det	the,factor
R1273	T1524	T1526	amod	cellular,factor
R1274	T1525	T1526	compound	restriction,factor
R1275	T1526	T1522	pobj	factor,as
R1276	T1527	T1528	nsubj	that,is
R1277	T1528	T1526	relcl	is,factor
R1278	T1529	T1528	acomp	responsible,is
R1279	T1530	T1529	prep	for,responsible
R1280	T1531	T1530	pobj	inhibition,for
R1281	T1532	T1531	prep	of,inhibition
R1282	T1533	T1535	compound	virion,factor
R1283	T1534	T1535	compound	infectivity,factor
R1284	T1535	T1532	pobj	factor,of
R1285	T1536	T1537	punct	(,Vif
R1286	T1537	T1535	appos	Vif,factor
R1287	T1538	T1537	punct	),Vif
R1288	T1539	T1535	punct	-,factor
R1289	T1540	T1543	amod	deleted,virus-1
R1290	T1541	T1542	amod	human,immunodeficiency
R1291	T1542	T1543	compound	immunodeficiency,virus-1
R1292	T1543	T1535	appos	virus-1,factor
R1293	T1544	T1547	punct	(,replication
R1294	T1545	T1547	nmod	HIV-1,replication
R1295	T1546	T1547	punct	),replication
R1296	T1547	T1543	appos	replication,virus-1
R1297	T1548	T1547	prep	in,replication
R1298	T1549	T1550	amod	non-permissive,cells
R1299	T1550	T1548	pobj	cells,in
R1300	T1551	T1547	punct	(,replication
R1301	T1552	T1547	dep	4,replication
R1302	T1553	T1547	punct	),replication
R1303	T1554	T1521	punct	.,identified
R1304	T1555	T1556	nsubj	A3G,is
R1305	T1556	T1557	auxpass	is,packaged
R1306	T1557	T1557	ROOT	packaged,packaged
R1307	T1558	T1557	prep	into,packaged
R1308	T1559	T1560	amod	HIV-1Δvif,particles
R1309	T1560	T1558	pobj	particles,into
R1310	T1561	T1557	cc	and,packaged
R1311	T1562	T1557	conj	causes,packaged
R1312	T1563	T1564	compound	C-to-U,deaminations
R1313	T1564	T1562	dobj	deaminations,causes
R1314	T1565	T1562	prep	on,causes
R1315	T1566	T1569	det	the,DNA
R1316	T1567	T1569	amod	single-stranded,DNA
R1317	T1568	T1569	amod	viral,DNA
R1318	T1569	T1565	pobj	DNA,on
R1319	T1570	T1562	prep	during,causes
R1320	T1571	T1572	amod	reverse,transcription
R1321	T1572	T1570	pobj	transcription,during
R1322	T1573	T1572	punct	(,transcription
R1323	T1574	T1572	appos	5,transcription
R1324	T1575	T1572	appos	8,transcription
R1325	T1576	T1572	punct	),transcription
R1326	T1577	T1557	punct	.,packaged
R1327	T1578	T1579	nsubj	This,leads
R1328	T1579	T1579	ROOT	leads,leads
R1329	T1580	T1579	prep	to,leads
R1330	T1581	T1580	pobj	degradation,to
R1337	T1588	T1589	compound	repair,mechanisms
R1338	T1589	T1586	pobj	mechanisms,by
R1339	T1590	T1580	cc	or,to
R1340	T1647	T1648	punct	-,retrotransposons
R1341	T1591	T1580	conj	to,to
R1342	T1648	T1643	conj	retrotransposons,long-terminal-repeat
R1343	T1649	T1648	punct	",",retrotransposons
R1344	T1592	T1591	pobj	hypermutation,to
R1345	T1650	T1648	conj	orthohepadnaviruses,retrotransposons
R1346	T1651	T1650	cc	and,orthohepadnaviruses
R1347	T1593	T1592	prep	of,hypermutation
R1348	T1594	T1596	det	the,genome
R1349	T1652	T1650	conj	avihepadnaviruses,orthohepadnaviruses
R1350	T1595	T1596	amod	viral,genome
R1351	T1653	T1655	punct	(,21
R1352	T1654	T1655	nummod	9,21
R1353	T1596	T1593	pobj	genome,of
R1354	T1655	T1652	appos	21,avihepadnaviruses
R1355	T1656	T1652	punct	),avihepadnaviruses
R1356	T1597	T1596	punct	(,genome
R1357	T1657	T1631	punct	.,restricts
R1358	T1658	T1661	advmod	Interestingly,seems
R1359	T1659	T1661	punct	",",seems
R1360	T1598	T1596	appos	"5,6",genome
R1361	T1660	T1661	nsubj	deamination,seems
R1362	T1661	T1695	ccomp	seems,shown
R1363	T1662	T1664	neg	not,be
R1364	T1599	T1596	punct	),genome
R1365	T1663	T1664	aux	to,be
R1366	T1664	T1661	xcomp	be,seems
R1367	T1600	T1579	punct	.,leads
R1368	T1665	T1669	det	the,mechanism
R1369	T1601	T1614	prep	As,is
R1370	T1602	T1603	det	a,result
R1372	T1603	T1601	pobj	result,As
R1373	T1604	T1614	punct	",",is
R1375	T1605	T1608	advmod	only,fraction
R1376	T1606	T1608	det	a,fraction
R1378	T1607	T1608	amod	marginal,fraction
R1379	T1608	T1614	nsubj	fraction,is
R1381	T1609	T1608	prep	of,fraction
R1382	T1610	T1613	det	the,particles
R1383	T1670	T1695	punct	;,shown
R1384	T1671	T1695	prep	in,shown
R1385	T1672	T1673	det	the,case
R1386	T1611	T1613	amod	A3G-containing,particles
R1387	T1673	T1671	pobj	case,in
R1388	T1674	T1673	prep	of,case
R1389	T1675	T1676	compound	hepatitis,B
R1390	T1612	T1613	compound	HIV-1,particles
R1391	T1676	T1677	compound	B,virus
R1392	T1677	T1674	pobj	virus,of
R1393	T1678	T1679	punct	(,HBV
R1394	T1679	T1677	appos	HBV,virus
R1395	T1613	T1609	pobj	particles,of
R1396	T1680	T1679	punct	),HBV
R1397	T1681	T1677	cc	and,virus
R1398	T1682	T1684	amod	human,cell
R1399	T1614	T1614	ROOT	is,is
R1400	T1683	T1684	compound	T,cell
R1401	T1684	T1685	compound	cell,leukemia
R1402	T1615	T1614	acomp	able,is
R1403	T1685	T1686	compound	leukemia,virus
R1404	T1686	T1687	compound	virus,type
R1405	T1687	T1695	npadvmod	type,shown
R1406	T1688	T1687	nummod	1,type
R1407	T1689	T1687	punct	(,type
R1408	T1690	T1687	appos	HTLV-1,type
R1409	T1691	T1687	punct	),type
R1410	T1616	T1617	aux	to,complete
R1411	T1692	T1695	punct	",",shown
R1412	T1693	T1695	nsubjpass	A3G,shown
R1413	T1694	T1695	auxpass	was,shown
R1414	T1617	T1615	xcomp	complete,able
R1415	T1695	T1695	ROOT	shown,shown
R1416	T1696	T1697	aux	to,restrict
R1417	T1697	T1695	xcomp	restrict,shown
R1418	T1618	T1620	det	the,cycle
R1419	T1698	T1699	compound	virus,replication
R1420	T1699	T1697	dobj	replication,restrict
R1421	T1700	T1697	prep	by,restrict
R1422	T1619	T1620	compound	replication,cycle
R1423	T1701	T1702	amod	deamination-independent,mechanisms
R1424	T1702	T1700	pobj	mechanisms,by
R1425	T1703	T1702	punct	(,mechanisms
R1426	T1620	T1617	dobj	cycle,complete
R1427	T1704	T1706	nummod	12,13
R1428	T1705	T1706	punct	",",13
R1429	T1621	T1614	punct	.,is
R1430	T1706	T1702	appos	13,mechanisms
R1431	T1707	T1702	punct	",",mechanisms
R1432	T1708	T1710	quantmod	19,22
R1433	T1622	T1631	prep	In,restricts
R1434	T1709	T1710	punct	",",22
R1435	T1710	T1702	appos	22,mechanisms
R1436	T1711	T1710	appos	25,22
R1437	T1623	T1622	pobj	addition,In
R1438	T1712	T1710	punct	),22
R1439	T1713	T1695	punct	.,shown
R1440	T1714	T1715	det	Another,member
R1441	T1624	T1623	prep	to,addition
R1442	T1715	T1726	nsubj	member,appears
R1443	T1716	T1715	prep	of,member
R1444	T1717	T1719	det	the,family
R1445	T1625	T1626	det	the,inhibition
R1446	T1718	T1719	compound	APOBEC3,family
R1447	T1719	T1716	pobj	family,of
R1448	T1720	T1719	punct	",",family
R1449	T1626	T1624	pobj	inhibition,to
R1450	T1721	T1719	appos	APOBEC3F,family
R1451	T1722	T1723	punct	(,A3F
R1452	T1723	T1721	appos	A3F,APOBEC3F
R1453	T1627	T1626	prep	of,inhibition
R1454	T1724	T1721	punct	),APOBEC3F
R1455	T1725	T1726	punct	",",appears
R1456	T1726	T1726	ROOT	appears,appears
R1457	T1727	T1728	aux	to,have
R1458	T1728	T1726	xcomp	have,appears
R1459	T1729	T1730	amod	similar,activities
R1460	T1628	T1627	pobj	HIV-1,of
R1461	T1730	T1728	dobj	activities,have
R1462	T1731	T1730	prep	like,activities
R1463	T1732	T1731	pobj	A3G,like
R1464	T1629	T1631	punct	",",restricts
R1465	T1733	T1734	punct	(,"26,27"
R1466	T1734	T1732	parataxis	"26,27",A3G
R1467	T1735	T1726	punct	),appears
R1468	T1630	T1631	nsubj	A3G,restricts
R1469	T1736	T1726	punct	.,appears
R1470	T1631	T1631	ROOT	restricts,restricts
R1471	T1737	T1740	nsubjpass	A3F,packaged
R1472	T1632	T1631	dobj	replication,restricts
R1473	T1738	T1740	auxpass	is,packaged
R1474	T1739	T1740	advmod	also,packaged
R1475	T1633	T1632	prep	of,replication
R1476	T1740	T1740	ROOT	packaged,packaged
R1477	T1741	T1740	prep	into,packaged
R1478	T1742	T1743	amod	HIV-1Δvif,particles
R1479	T1634	T1635	amod	other,lentiviruses
R1480	T1743	T1741	pobj	particles,into
R1481	T1744	T1740	cc	and,packaged
R1482	T1635	T1633	pobj	lentiviruses,of
R1483	T1745	T1740	conj	induces,packaged
R1484	T1746	T1748	amod	similar,deaminations
R1485	T1636	T1635	punct	",",lentiviruses
R1486	T1637	T1635	conj	gammaretroviruses,lentiviruses
R1487	T1638	T1637	punct	",",gammaretroviruses
R1488	T1639	T1637	conj	deltaretroviruses,gammaretroviruses
R1489	T1640	T1639	punct	",",deltaretroviruses
R1490	T1747	T1748	compound	C-to-U,deaminations
R1491	T1641	T1639	conj	spumaviruses,deltaretroviruses
R1492	T1748	T1745	dobj	deaminations,induces
R1493	T1749	T1745	punct	",",induces
R1494	T1642	T1641	punct	",",spumaviruses
R1495	T1750	T1753	mark	although,differ
R1496	T1643	T1641	conj	long-terminal-repeat,spumaviruses
R1497	T1751	T1752	det	the,proteins
R1498	T1752	T1753	nsubj	proteins,differ
R1499	T1753	T1745	advcl	differ,induces
R1500	T1644	T1645	punct	(,LTR
R1501	T1754	T1753	prep	in,differ
R1502	T1755	T1757	poss	their,sequences
R1503	T1756	T1757	compound	target,sequences
R1504	T1645	T1643	appos	LTR,long-terminal-repeat
R1505	T1757	T1758	compound	sequences,specificity
R1506	T1758	T1754	pobj	specificity,in
R1507	T1759	T1758	punct	(,specificity
R1508	T1760	T1758	appos	"26,28",specificity
R1509	T1761	T1758	punct	),specificity
R1510	T1762	T1740	punct	.,packaged
R1511	T1763	T1768	advmod	Furthermore,detected
R1512	T1646	T1645	punct	),LTR
R1513	T1764	T1768	punct	",",detected
R1514	T1765	T1766	compound	A3F,proteins
R1515	T1766	T1768	nsubjpass	proteins,detected
R1516	T1844	T1845	expl	There,is
R1517	T1767	T1768	auxpass	were,detected
R1518	T1768	T1768	ROOT	detected,detected
R1519	T1845	T1845	ROOT	is,is
R1520	T1769	T1768	prep	in,detected
R1521	T1770	T1771	amod	many,tissues
R1522	T1771	T1769	pobj	tissues,in
R1523	T1846	T1847	det	a,report
R1524	T1772	T1773	nsubj	that,express
R1525	T1773	T1771	relcl	express,tissues
R1526	T1847	T1845	attr	report,is
R1527	T1774	T1773	dobj	A3G,express
R1528	T1775	T1773	cc	and,express
R1529	T1776	T1768	conj	are,detected
R1530	T1848	T1847	acl	describing,report
R1531	T1777	T1776	acomp	able,are
R1532	T1778	T1779	aux	to,form
R1533	T1779	T1777	xcomp	form,able
R1534	T1780	T1779	dobj	heteromultimers,form
R1535	T1849	T1851	det	that,stimulation
R1536	T1781	T1779	prep	with,form
R1537	T1782	T1781	pobj	A3G,with
R1538	T1850	T1851	amod	mitogenic,stimulation
R1539	T1783	T1784	punct	(,"26,29,30"
R1540	T1784	T1782	parataxis	"26,29,30",A3G
R1541	T1785	T1776	punct	),are
R1542	T1851	T1848	dobj	stimulation,describing
R1543	T1786	T1768	punct	.,detected
R1544	T1787	T1788	det	Both,proteins
R1545	T1788	T1789	nsubj	proteins,localize
R1546	T1852	T1851	prep	of,stimulation
R1547	T1789	T1789	ROOT	localize,localize
R1548	T1790	T1789	prep	to,localize
R1549	T1853	T1854	compound	T,cells
R1550	T1791	T1792	compound	mRNA,processing
R1551	T1792	T1790	pobj	processing,to
R1552	T1793	T1794	punct	(,P
R1553	T1854	T1852	pobj	cells,of
R1554	T1794	T1792	appos	P,processing
R1555	T1795	T1790	punct	),to
R1556	T1796	T1789	dobj	bodies,localize
R1557	T1797	T1796	punct	",",bodies
R1558	T1798	T1799	amod	cytoplasmic,compartments
R1559	T1799	T1796	conj	compartments,bodies
R1560	T1800	T1799	acl	involved,compartments
R1561	T1855	T1845	dep	upregulates,is
R1562	T1801	T1800	prep	in,involved
R1563	T1802	T1803	det	the,degradation
R1564	T1803	T1801	pobj	degradation,in
R1565	T1856	T1857	compound	A3G,mRNA
R1566	T1804	T1803	cc	and,degradation
R1567	T1805	T1803	conj	storage,degradation
R1568	T1806	T1803	prep	of,degradation
R1569	T1807	T1808	amod	non-translating,mRNAs
R1570	T1857	T1858	compound	mRNA,levels
R1571	T1808	T1806	pobj	mRNAs,of
R1572	T1809	T1808	punct	(,mRNAs
R1573	T1858	T1855	dobj	levels,upregulates
R1574	T1810	T1808	appos	"30,31",mRNAs
R1575	T1811	T1808	punct	),mRNAs
R1576	T1812	T1789	punct	.,localize
R1577	T1859	T1845	punct	",",is
R1578	T1813	T1816	nsubjpass	A3G,shown
R1579	T1814	T1816	aux	has,shown
R1580	T1860	T1845	cc	but,is
R1581	T1815	T1816	auxpass	been,shown
R1582	T1861	T1864	nsubjpass	this,analyzed
R1583	T1816	T1816	ROOT	shown,shown
R1584	T1817	T1819	aux	to,expressed
R1585	T1862	T1864	auxpass	was,analyzed
R1586	T1818	T1819	auxpass	be,expressed
R1587	T1819	T1816	xcomp	expressed,shown
R1588	T1820	T1819	prep	in,expressed
R1589	T1863	T1864	neg	not,analyzed
R1590	T1821	T1822	compound	T,cells
R1591	T1822	T1820	pobj	cells,in
R1592	T1864	T1845	conj	analyzed,is
R1593	T1823	T1819	punct	",",expressed
R1594	T1824	T1827	det	a,target
R1595	T1825	T1827	amod	relevant,target
R1596	T1865	T1864	prep	on,analyzed
R1597	T1826	T1827	compound	cell,target
R1598	T1866	T1868	det	the,level
R1599	T1827	T1816	dobj	target,shown
R1600	T1828	T1827	prep	for,target
R1601	T1829	T1828	pobj	HIV-1,for
R1602	T1830	T1816	prep	in,shown
R1603	T1867	T1868	amod	transcriptional,level
R1604	T1831	T1830	pobj	vivo,in
R1605	T1832	T1816	punct	",",shown
R1606	T1833	T1816	cc	but,shown
R1607	T1834	T1836	advmod	little,known
R1608	T1835	T1836	auxpass	is,known
R1609	T1836	T1816	conj	known,shown
R1610	T1837	T1836	prep	about,known
R1611	T1868	T1865	pobj	level,on
R1612	T1838	T1839	poss	its,regulation
R1613	T1839	T1837	pobj	regulation,about
R1614	T1840	T1839	punct	(,regulation
R1615	T1869	T1868	punct	(,level
R1616	T1841	T1839	appos	"4,29,32",regulation
R1617	T1842	T1839	punct	),regulation
R1618	T1843	T1816	punct	.,shown
R1619	T1870	T1868	appos	33,level
R1620	T1871	T1868	punct	),level
R1621	T1872	T1864	punct	.,analyzed
R1622	T1873	T1881	mark	Since,analyzed
R1623	T1940	T1938	dobj	transcription,mediated
R1624	T1941	T1932	punct	.,identified
R1625	T1942	T1952	prep	In,was
R1626	T1874	T1876	det	the,promoter
R1627	T1943	T1944	compound	T,cells
R1628	T1944	T1942	pobj	cells,In
R1629	T1875	T1876	compound	A3G,promoter
R1630	T1876	T1881	nsubj	promoter,analyzed
R1631	T1877	T1881	aux	has,analyzed
R1632	T1945	T1947	punct	",",activity
R1633	T1878	T1881	neg	not,analyzed
R1634	T1946	T1947	amod	transcriptional,activity
R1635	T1947	T1952	nsubj	activity,was
R1636	T1948	T1947	prep	of,activity
R1637	T1879	T1881	auxpass	been,analyzed
R1638	T1949	T1951	det	this,promoter
R1639	T1950	T1951	compound	core,promoter
R1640	T1880	T1881	advmod	systematically,analyzed
R1641	T1951	T1948	pobj	promoter,of
R1642	T1952	T1952	ROOT	was,was
R1643	T1953	T1952	neg	not,was
R1644	T1881	T1887	advcl	analyzed,was
R1645	T1954	T1952	acomp	inducible,was
R1646	T1955	T1954	agent	by,inducible
R1647	T1956	T1957	amod	mitogenic,stimulation
R1648	T1882	T1883	advmod	so,far
R1649	T1957	T1955	pobj	stimulation,by
R1650	T1958	T1957	cc	or,stimulation
R1651	T1959	T1957	conj	interferon,stimulation
R1652	T1883	T1881	advmod	far,analyzed
R1653	T1960	T1957	conj	treatment,stimulation
R1654	T1961	T1952	punct	",",was
R1655	T1884	T1887	punct	",",was
R1656	T1962	T1952	cc	but,was
R1657	T1963	T1952	conj	was,was
R1658	T1964	T1963	acomp	dependent,was
R1659	T1965	T1964	prep	on,dependent
R1660	T1966	T1967	det	a,GC-box
R1661	T1967	T1965	pobj	GC-box,on
R1662	T1885	T1886	poss	our,aim
R1663	T1968	T1970	nsubjpass	which,recognized
R1664	T1969	T1970	auxpass	was,recognized
R1665	T1970	T1967	relcl	recognized,GC-box
R1666	T1971	T1970	agent	by,recognized
R1667	T1886	T1887	nsubj	aim,was
R1668	T1887	T1887	ROOT	was,was
R1669	T1972	T1971	pobj	Sp,by
R1670	T1888	T1889	aux	to,clone
R1671	T1973	T1975	punct	(,protein
R1672	T1974	T1975	compound	specificity,protein
R1673	T1889	T1887	xcomp	clone,was
R1674	T1975	T1967	appos	protein,GC-box
R1675	T1976	T1963	punct	),was
R1676	T1977	T1976	nummod	1,)
R1677	T1890	T1892	det	the,promoter
R1678	T1978	T1963	cc	and,was
R1679	T1979	T1963	conj	Sp3,was
R1680	T1891	T1892	compound	A3G,promoter
R1681	T1980	T1981	compound	transcription,factors
R1682	T1981	T1979	dobj	factors,Sp3
R1683	T1982	T1952	punct	.,was
R1684	T1892	T1889	dobj	promoter,clone
R1685	T1893	T1889	cc	and,clone
R1686	T1894	T1889	conj	characterize,clone
R1687	T1895	T1896	poss	its,regulation
R1688	T1896	T1894	dobj	regulation,characterize
R1689	T1897	T1896	prep	in,regulation
R1690	T1898	T1899	compound	T,cells
R1691	T1899	T1897	pobj	cells,in
R1692	T1900	T1887	punct	.,was
R1693	T1901	T1906	prep	In,observed
R1694	T1902	T1903	poss	our,study
R1695	T1903	T1901	pobj	study,In
R1696	T1904	T1906	punct	",",observed
R1697	T1905	T1906	nsubj	we,observed
R1698	T1906	T1906	ROOT	observed,observed
R1699	T1907	T1909	mark	that,uses
R1700	T1908	T1909	nsubj	A3G,uses
R1701	T1909	T1906	ccomp	uses,observed
R1702	T1910	T1913	amod	multiple,sites
R1703	T1911	T1912	amod	transcriptional,start
R1704	T1912	T1913	compound	start,sites
R1705	T1913	T1909	dobj	sites,uses
R1706	T1914	T1915	punct	(,TSS
R1707	T1915	T1909	npadvmod	TSS,uses
R1710	T1916	T1915	punct	),TSS
R1712	T1917	T1906	punct	.,observed
R1713	T1918	T1932	prep	By,identified
R1714	T1919	T1918	pcomp	generating,By
R1716	T1920	T1921	det	a,series
R1717	T1921	T1919	dobj	series,generating
R1721	T1922	T1921	prep	of,series
R1724	T1923	T1925	nummod	5,deletions
R1726	T1924	T1925	nummod	′,deletions
R1731	T1925	T1922	pobj	deletions,of
R1733	T1926	T1925	prep	of,deletions
R1735	T1927	T1929	det	the,promoter
R1738	T1928	T1929	compound	A3G,promoter
R1739	T1929	T1926	pobj	promoter,of
R1743	T1930	T1932	punct	",",identified
R1746	T1931	T1932	nsubj	we,identified
R1747	T1932	T1932	ROOT	identified,identified
R1748	T1933	T1936	det	a,region
R1749	T1934	T1936	nummod	180,region
R1750	T1935	T1936	compound	bp,region
R1751	T1936	T1932	dobj	region,identified
R1752	T1937	T1938	nsubj	that,mediated
R1753	T1938	T1936	relcl	mediated,region
R1754	T1939	T1940	amod	basal,transcription
R1331	T1582	T1581	prep	of,degradation
R1332	T1583	T1585	det	the,DNA
R1333	T1584	T1585	amod	uracile-containing,DNA
R1334	T1585	T1582	pobj	DNA,of
R1335	T1586	T1581	prep	by,degradation
R1336	T1587	T1589	amod	cellular,mechanisms
R1371	T1666	T1669	amod	only,mechanism
R1374	T1667	T1669	amod	A3G-mediated,mechanism
R1377	T1668	T1669	amod	antiviral,mechanism
R1380	T1669	T1664	attr	mechanism,be

sentences

Id	Subject	Object	Predicate	Lexical cue
T848	13-153	Sentence	denotes	The recently discovered APOBEC3 family of cytidine deaminases is considered to play an important role in antiviral intrinsic immunity (1,2).
T849	154-295	Sentence	denotes	In primates, the seven paralogs APOBEC3A, B, C, DE, F, G, H (A3A-H) have been described (3), and they appear to fulfill individual functions.
T850	296-578	Sentence	denotes	Human APOBEC3G (A3G), the most prominent member of the APOBEC3 family has been identified as the cellular restriction factor that is responsible for inhibition of virion infectivity factor (Vif)-deleted human immunodeficiency virus-1 (HIV-1) replication in non-permissive cells (4).
T851	579-719	Sentence	denotes	A3G is packaged into HIV-1Δvif particles and causes C-to-U deaminations on the single-stranded viral DNA during reverse transcription (5–8).
T852	720-852	Sentence	denotes	This leads to degradation of the uracile-containing DNA by cellular repair mechanisms or to hypermutation of the viral genome (5,6).
T853	853-971	Sentence	denotes	As a result, only a marginal fraction of the A3G-containing HIV-1 particles is able to complete the replication cycle.
T854	972-1207	Sentence	denotes	In addition to the inhibition of HIV-1, A3G restricts replication of other lentiviruses, gammaretroviruses, deltaretroviruses, spumaviruses, long-terminal-repeat (LTR)-retrotransposons, orthohepadnaviruses and avihepadnaviruses (9–21).
T855	1208-1484	Sentence	denotes	Interestingly, deamination seems not to be the only A3G-mediated antiviral mechanism; in the case of hepatitis B virus (HBV) and human T cell leukemia virus type 1 (HTLV-1), A3G was shown to restrict virus replication by deamination-independent mechanisms (12, 13, 19, 22–25).
T856	1485-1591	Sentence	denotes	Another member of the APOBEC3 family, APOBEC3F (A3F), appears to have similar activities like A3G (26,27).
T857	1592-1754	Sentence	denotes	A3F is also packaged into HIV-1Δvif particles and induces similar C-to-U deaminations, although the proteins differ in their target sequences specificity (26,28).
T858	1755-1885	Sentence	denotes	Furthermore, A3F proteins were detected in many tissues that express A3G and are able to form heteromultimers with A3G (26,29,30).
T859	1886-2038	Sentence	denotes	Both proteins localize to mRNA processing (P) bodies, cytoplasmic compartments involved in the degradation and storage of non-translating mRNAs (30,31).
T860	2039-2179	Sentence	denotes	A3G has been shown to be expressed in T cells, a relevant cell target for HIV-1 in vivo, but little is known about its regulation (4,29,32).
T861	2180-2336	Sentence	denotes	There is a report describing that mitogenic stimulation of T cells upregulates A3G mRNA levels, but this was not analyzed on the transcriptional level (33).
T862	2337-2486	Sentence	denotes	Since the A3G promoter has not been systematically analyzed so far, our aim was to clone the A3G promoter and characterize its regulation in T cells.
T863	2487-2570	Sentence	denotes	In our study, we observed that A3G uses multiple transcriptional start sites (TSS).
T864	2571-2695	Sentence	denotes	By generating a series of 5′ deletions of the A3G promoter, we identified a 180 bp region that mediated basal transcription.
T865	2696-2934	Sentence	denotes	In T cells, transcriptional activity of this core promoter was not inducible by mitogenic stimulation or interferon treatment, but was dependent on a GC-box which was recognized by Sp (specificity protein) 1 and Sp3 transcription factors.
T11	0-12	Sentence	denotes	INTRODUCTION
T12	13-153	Sentence	denotes	The recently discovered APOBEC3 family of cytidine deaminases is considered to play an important role in antiviral intrinsic immunity (1,2).
T13	154-295	Sentence	denotes	In primates, the seven paralogs APOBEC3A, B, C, DE, F, G, H (A3A-H) have been described (3), and they appear to fulfill individual functions.
T14	296-578	Sentence	denotes	Human APOBEC3G (A3G), the most prominent member of the APOBEC3 family has been identified as the cellular restriction factor that is responsible for inhibition of virion infectivity factor (Vif)-deleted human immunodeficiency virus-1 (HIV-1) replication in non-permissive cells (4).
T15	579-719	Sentence	denotes	A3G is packaged into HIV-1Δvif particles and causes C-to-U deaminations on the single-stranded viral DNA during reverse transcription (5–8).
T16	720-852	Sentence	denotes	This leads to degradation of the uracile-containing DNA by cellular repair mechanisms or to hypermutation of the viral genome (5,6).
T17	853-971	Sentence	denotes	As a result, only a marginal fraction of the A3G-containing HIV-1 particles is able to complete the replication cycle.
T18	972-1207	Sentence	denotes	In addition to the inhibition of HIV-1, A3G restricts replication of other lentiviruses, gammaretroviruses, deltaretroviruses, spumaviruses, long-terminal-repeat (LTR)-retrotransposons, orthohepadnaviruses and avihepadnaviruses (9–21).
T19	1208-1484	Sentence	denotes	Interestingly, deamination seems not to be the only A3G-mediated antiviral mechanism; in the case of hepatitis B virus (HBV) and human T cell leukemia virus type 1 (HTLV-1), A3G was shown to restrict virus replication by deamination-independent mechanisms (12, 13, 19, 22–25).
T20	1485-1591	Sentence	denotes	Another member of the APOBEC3 family, APOBEC3F (A3F), appears to have similar activities like A3G (26,27).
T21	1592-1754	Sentence	denotes	A3F is also packaged into HIV-1Δvif particles and induces similar C-to-U deaminations, although the proteins differ in their target sequences specificity (26,28).
T22	1755-1885	Sentence	denotes	Furthermore, A3F proteins were detected in many tissues that express A3G and are able to form heteromultimers with A3G (26,29,30).
T23	1886-2038	Sentence	denotes	Both proteins localize to mRNA processing (P) bodies, cytoplasmic compartments involved in the degradation and storage of non-translating mRNAs (30,31).
T24	2039-2179	Sentence	denotes	A3G has been shown to be expressed in T cells, a relevant cell target for HIV-1 in vivo, but little is known about its regulation (4,29,32).
T25	2180-2336	Sentence	denotes	There is a report describing that mitogenic stimulation of T cells upregulates A3G mRNA levels, but this was not analyzed on the transcriptional level (33).
T26	2337-2486	Sentence	denotes	Since the A3G promoter has not been systematically analyzed so far, our aim was to clone the A3G promoter and characterize its regulation in T cells.
T27	2487-2570	Sentence	denotes	In our study, we observed that A3G uses multiple transcriptional start sites (TSS).
T28	2571-2695	Sentence	denotes	By generating a series of 5′ deletions of the A3G promoter, we identified a 180 bp region that mediated basal transcription.
T29	2696-2934	Sentence	denotes	In T cells, transcriptional activity of this core promoter was not inducible by mitogenic stimulation or interferon treatment, but was dependent on a GC-box which was recognized by Sp (specificity protein) 1 and Sp3 transcription factors.

2_test

Id	Subject	Object	Predicate	Lexical cue
17517765-16611054-77155574	148-149	16611054	denotes	1
17517765-16407183-77155575	150-151	16407183	denotes	2
17517765-15496950-77155576	243-244	15496950	denotes	3
17517765-12167863-77155577	575-576	12167863	denotes	4
17517765-12808465-77155578	716-717	12808465	denotes	8
17517765-12808466-77155578	716-717	12808466	denotes	8
17517765-15296758-77155578	716-717	15296758	denotes	8
17517765-12859895-77155578	716-717	12859895	denotes	8
17517765-12808465-77155579	847-848	12808465	denotes	5
17517765-12808466-77155580	849-850	12808466	denotes	6
17517765-15956565-77155581	1203-1205	15956565	denotes	21
17517765-15994766-77155581	1203-1205	15994766	denotes	21
17517765-15911774-77155581	1203-1205	15911774	denotes	21
17517765-15943885-77155581	1203-1205	15943885	denotes	21
17517765-16025511-77155581	1203-1205	16025511	denotes	21
17517765-16000409-77155581	1203-1205	16000409	denotes	21
17517765-16378963-77155581	1203-1205	16378963	denotes	21
17517765-15823539-77155581	1203-1205	15823539	denotes	21
17517765-15674295-77155581	1203-1205	15674295	denotes	21
17517765-15031497-77155581	1203-1205	15031497	denotes	21
17517765-15353783-77155581	1203-1205	15353783	denotes	21
17517765-15479843-77155581	1203-1205	15479843	denotes	21
17517765-12809610-77155581	1203-1205	12809610	denotes	21
17517765-15943885-77155582	1465-1467	15943885	denotes	12
17517765-16025511-77155583	1469-1471	16025511	denotes	13
17517765-15353783-77155584	1473-1475	15353783	denotes	19
17517765-12970355-77155585	1480-1482	12970355	denotes	25
17517765-15726649-77155585	1480-1482	15726649	denotes	25
17517765-15668174-77155585	1480-1482	15668174	denotes	25
17517765-15921532-77155585	1480-1482	15921532	denotes	25
17517765-15296757-77155586	1584-1586	15296757	denotes	26
17517765-15141007-77155587	1587-1589	15141007	denotes	27
17517765-15296757-77155588	1747-1749	15296757	denotes	26
17517765-15647250-77155589	1750-1752	15647250	denotes	28
17517765-15296757-77155590	1875-1877	15296757	denotes	26
17517765-15152192-77155591	1878-1880	15152192	denotes	29
17517765-16699599-77155592	1881-1883	16699599	denotes	30
17517765-16699599-77155593	2031-2033	16699599	denotes	30
17517765-17166910-77155594	2034-2036	17166910	denotes	31
17517765-12167863-77155595	2170-2171	12167863	denotes	4
17517765-15152192-77155596	2172-2174	15152192	denotes	29
17517765-11863358-77155597	2175-2177	11863358	denotes	32
17517765-15297452-77155598	2332-2334	15297452	denotes	33

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T881	13-16	DT	denotes	The
T882	17-25	RB	denotes	recently
T883	26-36	VB	denotes	discovered
T884	37-44	NN	denotes	APOBEC3
T885	45-51	NN	denotes	family
T886	52-54	IN	denotes	of
T887	55-63	NN	denotes	cytidine
T888	64-74	NN	denotes	deaminases
T889	75-77	VB	denotes	is
T890	78-88	VB	denotes	considered
T891	89-91	TO	denotes	to
T892	92-96	VB	denotes	play
T893	97-99	DT	denotes	an
T894	100-109	JJ	denotes	important
T895	110-114	NN	denotes	role
T896	115-117	IN	denotes	in
T897	118-127	JJ	denotes	antiviral
T898	128-137	JJ	denotes	intrinsic
T899	138-146	NN	denotes	immunity
T900	147-148	-LRB-	denotes	(
T901	148-151	CD	denotes	1,2
T902	151-152	-RRB-	denotes	)
T903	154-156	IN	denotes	In
T904	157-165	NN	denotes	primates
T905	165-166	-COMMA-	denotes	,
T906	167-170	DT	denotes	the
T907	171-176	CD	denotes	seven
T908	177-185	NN	denotes	paralogs
T909	186-194	NN	denotes	APOBEC3A
T910	194-195	-COMMA-	denotes	,
T911	196-197	NN	denotes	B
T912	197-198	-COMMA-	denotes	,
T913	199-200	NN	denotes	C
T914	200-201	-COMMA-	denotes	,
T915	202-204	NNP	denotes	DE
T916	204-205	-COMMA-	denotes	,
T917	206-207	NN	denotes	F
T918	207-208	-COMMA-	denotes	,
T919	209-210	NN	denotes	G
T920	210-211	-COMMA-	denotes	,
T921	212-213	NN	denotes	H
T922	214-215	-LRB-	denotes	(
T923	215-220	NN	denotes	A3A-H
T924	220-221	-RRB-	denotes	)
T925	222-226	VB	denotes	have
T926	227-231	VB	denotes	been
T927	232-241	VB	denotes	described
T928	242-243	-LRB-	denotes	(
T929	243-244	CD	denotes	3
T930	244-245	-RRB-	denotes	)
T931	245-246	-COMMA-	denotes	,
T932	247-250	CC	denotes	and
T933	251-255	PRP	denotes	they
T934	256-262	VB	denotes	appear
T935	263-265	TO	denotes	to
T936	266-273	VB	denotes	fulfill
T937	274-284	JJ	denotes	individual
T938	285-294	NN	denotes	functions
T939	296-301	JJ	denotes	Human
T940	302-310	NN	denotes	APOBEC3G
T941	311-312	-LRB-	denotes	(
T942	312-315	NN	denotes	A3G
T943	315-316	-RRB-	denotes	)
T944	316-317	-COMMA-	denotes	,
T945	318-321	DT	denotes	the
T946	322-326	RB	denotes	most
T947	327-336	JJ	denotes	prominent
T948	337-343	NN	denotes	member
T949	344-346	IN	denotes	of
T950	347-350	DT	denotes	the
T951	351-358	NN	denotes	APOBEC3
T952	359-365	NN	denotes	family
T953	366-369	VB	denotes	has
T954	370-374	VB	denotes	been
T955	375-385	VB	denotes	identified
T956	386-388	IN	denotes	as
T957	389-392	DT	denotes	the
T958	393-401	JJ	denotes	cellular
T959	402-413	NN	denotes	restriction
T960	414-420	NN	denotes	factor
T961	421-425	WDT	denotes	that
T962	426-428	VB	denotes	is
T963	429-440	JJ	denotes	responsible
T964	441-444	IN	denotes	for
T965	445-455	NN	denotes	inhibition
T966	456-458	IN	denotes	of
T967	459-465	NN	denotes	virion
T968	466-477	NN	denotes	infectivity
T969	478-484	NN	denotes	factor
T970	485-486	-LRB-	denotes	(
T971	486-489	NN	denotes	Vif
T972	489-490	-RRB-	denotes	)
T973	490-498	JJ	denotes	-deleted
T974	499-504	JJ	denotes	human
T975	505-521	NN	denotes	immunodeficiency
T976	522-529	NN	denotes	virus-1
T977	530-531	-LRB-	denotes	(
T978	531-536	NN	denotes	HIV-1
T979	536-537	-RRB-	denotes	)
T980	538-549	NN	denotes	replication
T981	550-552	IN	denotes	in
T982	553-567	JJ	denotes	non-permissive
T983	568-573	NN	denotes	cells
T984	574-575	-LRB-	denotes	(
T985	575-576	CD	denotes	4
T986	576-577	-RRB-	denotes	)
T987	579-582	NN	denotes	A3G
T988	583-585	VB	denotes	is
T989	586-594	VB	denotes	packaged
T990	595-599	IN	denotes	into
T991	600-609	NN	denotes	HIV-1Δvif
T992	610-619	NN	denotes	particles
T993	620-623	CC	denotes	and
T994	624-630	VB	denotes	causes
T995	631-637	NN	denotes	C-to-U
T996	638-650	NN	denotes	deaminations
T997	651-653	IN	denotes	on
T998	654-657	DT	denotes	the
T999	658-673	JJ	denotes	single-stranded
T1000	674-679	JJ	denotes	viral
T1001	680-683	NN	denotes	DNA
T1002	684-690	IN	denotes	during
T1003	691-698	JJ	denotes	reverse
T1004	699-712	NN	denotes	transcription
T1005	713-714	-LRB-	denotes	(
T1006	714-717	CD	denotes	5–8
T1007	717-718	-RRB-	denotes	)
T1008	720-724	DT	denotes	This
T1009	725-730	VB	denotes	leads
T1010	731-733	TO	denotes	to
T1011	734-745	NN	denotes	degradation
T1012	746-748	IN	denotes	of
T1013	749-752	DT	denotes	the
T1014	753-771	JJ	denotes	uracile-containing
T1015	772-775	NN	denotes	DNA
T1016	776-778	IN	denotes	by
T1017	779-787	JJ	denotes	cellular
T1018	788-794	NN	denotes	repair
T1019	795-805	NN	denotes	mechanisms
T1020	806-808	CC	denotes	or
T1021	809-811	TO	denotes	to
T1022	812-825	NN	denotes	hypermutation
T1023	826-828	IN	denotes	of
T1024	829-832	DT	denotes	the
T1025	833-838	JJ	denotes	viral
T1026	839-845	NN	denotes	genome
T1027	846-847	-LRB-	denotes	(
T1028	847-850	CD	denotes	5,6
T1029	850-851	-RRB-	denotes	)
T1030	853-855	IN	denotes	As
T1031	856-857	DT	denotes	a
T1032	858-864	NN	denotes	result
T1033	864-865	-COMMA-	denotes	,
T1034	866-870	RB	denotes	only
T1035	871-872	DT	denotes	a
T1036	873-881	JJ	denotes	marginal
T1037	882-890	NN	denotes	fraction
T1038	891-893	IN	denotes	of
T1039	894-897	DT	denotes	the
T1040	898-912	JJ	denotes	A3G-containing
T1041	913-918	NN	denotes	HIV-1
T1042	919-928	NN	denotes	particles
T1043	929-931	VB	denotes	is
T1044	932-936	JJ	denotes	able
T1045	937-939	TO	denotes	to
T1046	940-948	VB	denotes	complete
T1047	949-952	DT	denotes	the
T1048	953-964	NN	denotes	replication
T1049	965-970	NN	denotes	cycle
T1050	972-974	IN	denotes	In
T1051	975-983	NN	denotes	addition
T1052	984-986	TO	denotes	to
T1053	987-990	DT	denotes	the
T1054	991-1001	NN	denotes	inhibition
T1055	1002-1004	IN	denotes	of
T1056	1005-1010	NN	denotes	HIV-1
T1057	1010-1011	-COMMA-	denotes	,
T1058	1012-1015	NN	denotes	A3G
T1059	1016-1025	VB	denotes	restricts
T1060	1026-1037	NN	denotes	replication
T1061	1038-1040	IN	denotes	of
T1062	1041-1046	JJ	denotes	other
T1063	1047-1059	NN	denotes	lentiviruses
T1064	1059-1060	-COMMA-	denotes	,
T1065	1061-1078	NN	denotes	gammaretroviruses
T1066	1078-1079	-COMMA-	denotes	,
T1067	1080-1097	NN	denotes	deltaretroviruses
T1068	1097-1098	-COMMA-	denotes	,
T1069	1099-1111	NN	denotes	spumaviruses
T1070	1111-1112	-COMMA-	denotes	,
T1071	1113-1133	NN	denotes	long-terminal-repeat
T1072	1134-1135	-LRB-	denotes	(
T1073	1135-1138	NN	denotes	LTR
T1074	1138-1139	-RRB-	denotes	)
T1075	1139-1156	NN	denotes	-retrotransposons
T1076	1156-1157	-COMMA-	denotes	,
T1077	1158-1177	NN	denotes	orthohepadnaviruses
T1078	1178-1181	CC	denotes	and
T1079	1182-1199	NN	denotes	avihepadnaviruses
T1080	1200-1201	-LRB-	denotes	(
T1081	1201-1205	CD	denotes	9–21
T1082	1205-1206	-RRB-	denotes	)
T1083	1208-1221	RB	denotes	Interestingly
T1084	1221-1222	-COMMA-	denotes	,
T1085	1223-1234	NN	denotes	deamination
T1086	1235-1240	VB	denotes	seems
T1087	1241-1244	RB	denotes	not
T1088	1245-1247	TO	denotes	to
T1089	1248-1250	VB	denotes	be
T1090	1251-1254	DT	denotes	the
T1091	1255-1259	JJ	denotes	only
T1092	1260-1272	JJ	denotes	A3G-mediated
T1093	1273-1282	JJ	denotes	antiviral
T1094	1283-1292	NN	denotes	mechanism
T1095	1292-1293	-COLON-	denotes	;
T1096	1294-1296	IN	denotes	in
T1097	1297-1300	DT	denotes	the
T1098	1301-1305	NN	denotes	case
T1099	1306-1308	IN	denotes	of
T1100	1309-1318	NN	denotes	hepatitis
T1101	1319-1320	NN	denotes	B
T1102	1321-1326	NN	denotes	virus
T1103	1327-1328	-LRB-	denotes	(
T1104	1328-1331	NN	denotes	HBV
T1105	1331-1332	-RRB-	denotes	)
T1106	1333-1336	CC	denotes	and
T1107	1337-1342	JJ	denotes	human
T1108	1343-1344	NN	denotes	T
T1109	1345-1349	NN	denotes	cell
T1110	1350-1358	NN	denotes	leukemia
T1111	1359-1364	NN	denotes	virus
T1112	1365-1369	NN	denotes	type
T1113	1370-1371	CD	denotes	1
T1114	1372-1373	-LRB-	denotes	(
T1115	1373-1379	NN	denotes	HTLV-1
T1116	1379-1380	-RRB-	denotes	)
T1117	1380-1381	-COMMA-	denotes	,
T1118	1382-1385	NN	denotes	A3G
T1119	1386-1389	VB	denotes	was
T1120	1390-1395	VB	denotes	shown
T1121	1396-1398	TO	denotes	to
T1122	1399-1407	VB	denotes	restrict
T1123	1408-1413	NN	denotes	virus
T1124	1414-1425	NN	denotes	replication
T1125	1426-1428	IN	denotes	by
T1126	1429-1452	JJ	denotes	deamination-independent
T1127	1453-1463	NN	denotes	mechanisms
T1128	1464-1465	-LRB-	denotes	(
T1129	1465-1467	CD	denotes	12
T1130	1467-1468	-COMMA-	denotes	,
T1131	1469-1471	CD	denotes	13
T1132	1471-1472	-COMMA-	denotes	,
T1133	1473-1475	CD	denotes	19
T1134	1475-1476	-COMMA-	denotes	,
T1135	1477-1482	CD	denotes	22–25
T1136	1482-1483	-RRB-	denotes	)
T1137	1485-1492	DT	denotes	Another
T1138	1493-1499	NN	denotes	member
T1139	1500-1502	IN	denotes	of
T1140	1503-1506	DT	denotes	the
T1141	1507-1514	NN	denotes	APOBEC3
T1142	1515-1521	NN	denotes	family
T1143	1521-1522	-COMMA-	denotes	,
T1144	1523-1531	NN	denotes	APOBEC3F
T1145	1532-1533	-LRB-	denotes	(
T1146	1533-1536	NN	denotes	A3F
T1147	1536-1537	-RRB-	denotes	)
T1148	1537-1538	-COMMA-	denotes	,
T1149	1539-1546	VB	denotes	appears
T1150	1547-1549	TO	denotes	to
T1151	1550-1554	VB	denotes	have
T1152	1555-1562	JJ	denotes	similar
T1153	1563-1573	NN	denotes	activities
T1154	1574-1578	IN	denotes	like
T1155	1579-1582	NN	denotes	A3G
T1156	1583-1584	-LRB-	denotes	(
T1157	1584-1589	CD	denotes	26,27
T1158	1589-1590	-RRB-	denotes	)
T1159	1592-1595	NN	denotes	A3F
T1160	1596-1598	VB	denotes	is
T1161	1599-1603	RB	denotes	also
T1162	1604-1612	VB	denotes	packaged
T1163	1613-1617	IN	denotes	into
T1164	1618-1627	NN	denotes	HIV-1Δvif
T1165	1628-1637	NN	denotes	particles
T1166	1638-1641	CC	denotes	and
T1167	1642-1649	VB	denotes	induces
T1168	1650-1657	JJ	denotes	similar
T1169	1658-1664	NN	denotes	C-to-U
T1170	1665-1677	NN	denotes	deaminations
T1171	1677-1678	-COMMA-	denotes	,
T1172	1679-1687	IN	denotes	although
T1173	1688-1691	DT	denotes	the
T1174	1692-1700	NN	denotes	proteins
T1175	1701-1707	VB	denotes	differ
T1176	1708-1710	IN	denotes	in
T1177	1711-1716	PRP-DOLLAR-	denotes	their
T1178	1717-1723	NN	denotes	target
T1179	1724-1733	NN	denotes	sequences
T1180	1734-1745	NN	denotes	specificity
T1181	1746-1747	-LRB-	denotes	(
T1182	1747-1752	CD	denotes	26,28
T1183	1752-1753	-RRB-	denotes	)
T1184	1755-1766	RB	denotes	Furthermore
T1185	1766-1767	-COMMA-	denotes	,
T1186	1768-1771	NN	denotes	A3F
T1187	1772-1780	NN	denotes	proteins
T1188	1781-1785	VB	denotes	were
T1189	1786-1794	VB	denotes	detected
T1190	1795-1797	IN	denotes	in
T1191	1798-1802	JJ	denotes	many
T1192	1803-1810	NN	denotes	tissues
T1193	1811-1815	WDT	denotes	that
T1194	1816-1823	VB	denotes	express
T1195	1824-1827	NN	denotes	A3G
T1196	1828-1831	CC	denotes	and
T1197	1832-1835	VB	denotes	are
T1198	1836-1840	JJ	denotes	able
T1199	1841-1843	TO	denotes	to
T1200	1844-1848	VB	denotes	form
T1201	1849-1864	NN	denotes	heteromultimers
T1202	1865-1869	IN	denotes	with
T1203	1870-1873	NN	denotes	A3G
T1204	1874-1875	-LRB-	denotes	(
T1205	1875-1883	CD	denotes	26,29,30
T1206	1883-1884	-RRB-	denotes	)
T1207	1886-1890	DT	denotes	Both
T1208	1891-1899	NN	denotes	proteins
T1209	1900-1908	VB	denotes	localize
T1210	1909-1911	TO	denotes	to
T1211	1912-1916	NN	denotes	mRNA
T1212	1917-1927	NN	denotes	processing
T1213	1928-1929	-LRB-	denotes	(
T1214	1929-1930	NN	denotes	P
T1215	1930-1931	-RRB-	denotes	)
T1216	1932-1938	NN	denotes	bodies
T1217	1938-1939	-COMMA-	denotes	,
T1218	1940-1951	JJ	denotes	cytoplasmic
T1219	1952-1964	NN	denotes	compartments
T1220	1965-1973	VB	denotes	involved
T1221	1974-1976	IN	denotes	in
T1222	1977-1980	DT	denotes	the
T1223	1981-1992	NN	denotes	degradation
T1224	1993-1996	CC	denotes	and
T1225	1997-2004	NN	denotes	storage
T1226	2005-2007	IN	denotes	of
T1227	2008-2023	JJ	denotes	non-translating
T1228	2024-2029	NN	denotes	mRNAs
T1229	2030-2031	-LRB-	denotes	(
T1230	2031-2036	CD	denotes	30,31
T1231	2036-2037	-RRB-	denotes	)
T1232	2039-2042	NN	denotes	A3G
T1233	2043-2046	VB	denotes	has
T1234	2047-2051	VB	denotes	been
T1235	2052-2057	VB	denotes	shown
T1236	2058-2060	TO	denotes	to
T1237	2061-2063	VB	denotes	be
T1238	2064-2073	VB	denotes	expressed
T1239	2074-2076	IN	denotes	in
T1240	2077-2078	NN	denotes	T
T1241	2079-2084	NN	denotes	cells
T1242	2084-2085	-COMMA-	denotes	,
T1243	2086-2087	DT	denotes	a
T1244	2088-2096	JJ	denotes	relevant
T1245	2097-2101	NN	denotes	cell
T1246	2102-2108	NN	denotes	target
T1247	2109-2112	IN	denotes	for
T1248	2113-2118	NN	denotes	HIV-1
T1249	2119-2121	FW	denotes	in
T1250	2122-2126	FW	denotes	vivo
T1251	2126-2127	-COMMA-	denotes	,
T1252	2128-2131	CC	denotes	but
T1253	2132-2138	JJ	denotes	little
T1254	2139-2141	VB	denotes	is
T1255	2142-2147	VB	denotes	known
T1256	2148-2153	IN	denotes	about
T1257	2154-2157	PRP-DOLLAR-	denotes	its
T1258	2158-2168	NN	denotes	regulation
T1259	2169-2170	-LRB-	denotes	(
T1260	2170-2177	CD	denotes	4,29,32
T1261	2177-2178	-RRB-	denotes	)
T1262	2180-2185	EX	denotes	There
T1263	2186-2188	VB	denotes	is
T1264	2189-2190	DT	denotes	a
T1265	2191-2197	NN	denotes	report
T1266	2198-2208	VB	denotes	describing
T1267	2209-2213	IN	denotes	that
T1268	2214-2223	JJ	denotes	mitogenic
T1269	2224-2235	NN	denotes	stimulation
T1270	2236-2238	IN	denotes	of
T1271	2239-2240	NN	denotes	T
T1272	2241-2246	NN	denotes	cells
T1273	2247-2258	VB	denotes	upregulates
T1274	2259-2262	NN	denotes	A3G
T1275	2263-2267	NN	denotes	mRNA
T1276	2268-2274	NN	denotes	levels
T1277	2274-2275	-COMMA-	denotes	,
T1278	2276-2279	CC	denotes	but
T1279	2280-2284	DT	denotes	this
T1280	2285-2288	VB	denotes	was
T1281	2289-2292	RB	denotes	not
T1282	2293-2301	VB	denotes	analyzed
T1283	2302-2304	IN	denotes	on
T1284	2305-2308	DT	denotes	the
T1285	2309-2324	JJ	denotes	transcriptional
T1286	2325-2330	NN	denotes	level
T1287	2331-2332	-LRB-	denotes	(
T1288	2332-2334	CD	denotes	33
T1289	2334-2335	-RRB-	denotes	)
T1290	2337-2342	IN	denotes	Since
T1291	2343-2346	DT	denotes	the
T1292	2347-2350	NN	denotes	A3G
T1293	2351-2359	NN	denotes	promoter
T1294	2360-2363	VB	denotes	has
T1295	2364-2367	RB	denotes	not
T1296	2368-2372	VB	denotes	been
T1297	2373-2387	RB	denotes	systematically
T1298	2388-2396	VB	denotes	analyzed
T1299	2397-2399	RB	denotes	so
T1300	2400-2403	RB	denotes	far
T1301	2403-2404	-COMMA-	denotes	,
T1302	2405-2408	PRP-DOLLAR-	denotes	our
T1303	2409-2412	NN	denotes	aim
T1304	2413-2416	VB	denotes	was
T1305	2417-2419	TO	denotes	to
T1306	2420-2425	VB	denotes	clone
T1307	2426-2429	DT	denotes	the
T1308	2430-2433	NN	denotes	A3G
T1309	2434-2442	NN	denotes	promoter
T1310	2443-2446	CC	denotes	and
T1311	2447-2459	VB	denotes	characterize
T1312	2460-2463	PRP-DOLLAR-	denotes	its
T1313	2464-2474	NN	denotes	regulation
T1314	2475-2477	IN	denotes	in
T1315	2478-2479	NN	denotes	T
T1316	2480-2485	NN	denotes	cells
T1317	2487-2489	IN	denotes	In
T1318	2490-2493	PRP-DOLLAR-	denotes	our
T1319	2494-2499	NN	denotes	study
T1320	2499-2500	-COMMA-	denotes	,
T1321	2501-2503	PRP	denotes	we
T1322	2504-2512	VB	denotes	observed
T1323	2513-2517	IN	denotes	that
T1324	2518-2521	NN	denotes	A3G
T1325	2522-2526	VB	denotes	uses
T1326	2527-2535	JJ	denotes	multiple
T1327	2536-2551	JJ	denotes	transcriptional
T1328	2552-2557	NN	denotes	start
T1329	2558-2563	NN	denotes	sites
T1330	2564-2565	-LRB-	denotes	(
T1331	2565-2568	NN	denotes	TSS
T1332	2568-2569	-RRB-	denotes	)
T1333	2571-2573	IN	denotes	By
T1334	2574-2584	VB	denotes	generating
T1335	2585-2586	DT	denotes	a
T1336	2587-2593	NN	denotes	series
T1337	2594-2596	IN	denotes	of
T1338	2597-2599	CD	denotes	5′
T1339	2600-2609	NN	denotes	deletions
T1340	2610-2612	IN	denotes	of
T1341	2613-2616	DT	denotes	the
T1342	2617-2620	NN	denotes	A3G
T1343	2621-2629	NN	denotes	promoter
T1344	2629-2630	-COMMA-	denotes	,
T1345	2631-2633	PRP	denotes	we
T1346	2634-2644	VB	denotes	identified
T1347	2645-2646	DT	denotes	a
T1348	2647-2653	NN	denotes	180 bp
T1349	2654-2660	NN	denotes	region
T1350	2661-2665	IN	denotes	that
T1351	2666-2674	VB	denotes	mediated
T1352	2675-2680	JJ	denotes	basal
T1353	2681-2694	NN	denotes	transcription
T1354	2696-2698	IN	denotes	In
T1355	2699-2700	NN	denotes	T
T1356	2701-2706	NN	denotes	cells
T1357	2706-2707	-COMMA-	denotes	,
T1358	2708-2723	JJ	denotes	transcriptional
T1359	2724-2732	NN	denotes	activity
T1360	2733-2735	IN	denotes	of
T1361	2736-2740	DT	denotes	this
T1362	2741-2745	NN	denotes	core
T1363	2746-2754	NN	denotes	promoter
T1364	2755-2758	VB	denotes	was
T1365	2759-2762	RB	denotes	not
T1366	2763-2772	JJ	denotes	inducible
T1367	2773-2775	IN	denotes	by
T1368	2776-2785	JJ	denotes	mitogenic
T1369	2786-2797	NN	denotes	stimulation
T1370	2798-2800	CC	denotes	or
T1371	2801-2811	NN	denotes	interferon
T1372	2812-2821	NN	denotes	treatment
T1373	2821-2822	-COMMA-	denotes	,
T1374	2823-2826	CC	denotes	but
T1375	2827-2830	VB	denotes	was
T1376	2831-2840	JJ	denotes	dependent
T1377	2841-2843	IN	denotes	on
T1378	2844-2845	DT	denotes	a
T1379	2846-2852	NN	denotes	GC-box
T1380	2853-2858	WDT	denotes	which
T1381	2859-2862	VB	denotes	was
T1382	2863-2873	VB	denotes	recognized
T1383	2874-2876	IN	denotes	by
T1384	2877-2879	NN	denotes	Sp
T1385	2880-2881	-LRB-	denotes	(
T1386	2881-2892	NN	denotes	specificity
T1387	2893-2900	NN	denotes	protein
T1388	2900-2901	-RRB-	denotes	)
T1389	2902-2903	CD	denotes	1
T1390	2904-2907	CC	denotes	and
T1391	2908-2911	NN	denotes	Sp3
T1392	2912-2925	NN	denotes	transcription
T1393	2926-2933	NN	denotes	factors
R658	T883	T882	arg1Of	discovered,recently
R659	T885	T881	arg1Of	family,The
R660	T885	T883	arg1Of	family,discovered
R661	T885	T884	arg1Of	family,APOBEC3
R662	T885	T886	arg1Of	family,of
R663	T885	T889	arg1Of	family,is
R664	T885	T890	arg2Of	family,considered
R665	T885	T892	arg1Of	family,play
R666	T888	T886	arg2Of	deaminases,of
R667	T888	T887	arg1Of	deaminases,cytidine
R668	T890	T889	arg2Of	considered,is
R669	T892	T890	arg3Of	play,considered
R670	T892	T891	arg1Of	play,to
R671	T892	T896	arg1Of	play,in
R672	T895	T892	arg2Of	role,play
R673	T895	T893	arg1Of	role,an
R674	T895	T894	arg1Of	role,important
R675	T899	T896	arg2Of	immunity,in
R676	T899	T897	arg1Of	immunity,antiviral
R677	T899	T898	arg1Of	immunity,intrinsic
R678	T899	T900	arg1Of	immunity,(
R679	T901	T900	arg2Of	"1,2",(
R680	T902	T900	arg3Of	),(
R681	T904	T903	arg2Of	primates,In
R682	T908	T906	arg1Of	paralogs,the
R683	T908	T907	arg1Of	paralogs,seven
R684	T909	T910	arg1Of	APOBEC3A,","
R685	T910	T912	arg1Of	",",","
R686	T911	T910	arg2Of	B,","
R687	T912	T914	arg1Of	",",","
R688	T913	T912	arg2Of	C,","
R689	T914	T916	arg1Of	",",","
R690	T915	T914	arg2Of	DE,","
R691	T916	T918	arg1Of	",",","
R692	T917	T916	arg2Of	F,","
R693	T918	T920	arg1Of	",",","
R694	T919	T918	arg2Of	G,","
R695	T920	T908	arg1Of	",",paralogs
R696	T920	T925	arg1Of	",",have
R697	T920	T926	arg1Of	",",been
R698	T920	T927	arg2Of	",",described
R699	T921	T920	arg2Of	H,","
R700	T921	T922	arg1Of	H,(
R701	T923	T922	arg2Of	A3A-H,(
R702	T924	T922	arg3Of	),(
R703	T927	T903	arg1Of	described,In
R704	T927	T905	arg1Of	described,","
R705	T927	T925	arg2Of	described,have
R706	T927	T926	arg2Of	described,been
R707	T927	T928	arg1Of	described,(
R708	T927	T932	arg1Of	described,and
R709	T929	T928	arg2Of	3,(
R710	T930	T928	arg3Of	),(
R711	T932	T931	arg1Of	and,","
R712	T933	T934	arg1Of	they,appear
R713	T933	T936	arg1Of	they,fulfill
R714	T934	T932	arg2Of	appear,and
R715	T936	T934	arg2Of	fulfill,appear
R716	T936	T935	arg1Of	fulfill,to
R717	T938	T936	arg2Of	functions,fulfill
R718	T938	T937	arg1Of	functions,individual
R719	T940	T939	arg1Of	APOBEC3G,Human
R720	T940	T941	arg1Of	APOBEC3G,(
R721	T940	T944	arg1Of	APOBEC3G,","
R722	T940	T953	arg1Of	APOBEC3G,has
R723	T940	T954	arg1Of	APOBEC3G,been
R724	T940	T955	arg2Of	APOBEC3G,identified
R725	T942	T941	arg2Of	A3G,(
R726	T943	T941	arg3Of	),(
R727	T947	T946	arg1Of	prominent,most
R728	T948	T944	arg2Of	member,","
R729	T948	T945	arg1Of	member,the
R730	T948	T947	arg1Of	member,prominent
R731	T948	T949	arg1Of	member,of
R732	T952	T949	arg2Of	family,of
R733	T952	T950	arg1Of	family,the
R734	T952	T951	arg1Of	family,APOBEC3
R735	T955	T953	arg2Of	identified,has
R736	T955	T954	arg2Of	identified,been
R737	T955	T956	arg1Of	identified,as
R738	T960	T956	arg2Of	factor,as
R739	T960	T957	arg1Of	factor,the
R740	T960	T958	arg1Of	factor,cellular
R741	T960	T959	arg1Of	factor,restriction
R742	T960	T961	arg1Of	factor,that
R743	T960	T962	arg1Of	factor,is
R744	T960	T963	arg1Of	factor,responsible
R745	T963	T962	arg2Of	responsible,is
R746	T963	T964	arg1Of	responsible,for
R747	T965	T964	arg2Of	inhibition,for
R748	T965	T966	arg1Of	inhibition,of
R749	T971	T970	arg2Of	Vif,(
R750	T972	T970	arg3Of	),(
R751	T978	T977	arg2Of	HIV-1,(
R752	T979	T977	arg3Of	),(
R753	T980	T966	arg2Of	replication,of
R754	T980	T967	arg1Of	replication,virion
R755	T980	T968	arg1Of	replication,infectivity
R756	T980	T969	arg1Of	replication,factor
R757	T980	T970	arg1Of	replication,(
R758	T980	T973	arg1Of	replication,-deleted
R759	T980	T974	arg1Of	replication,human
R760	T980	T975	arg1Of	replication,immunodeficiency
R761	T980	T976	arg1Of	replication,virus-1
R762	T980	T977	arg1Of	replication,(
R763	T980	T981	arg1Of	replication,in
R764	T983	T981	arg2Of	cells,in
R765	T983	T982	arg1Of	cells,non-permissive
R766	T983	T984	arg1Of	cells,(
R767	T985	T984	arg2Of	4,(
R768	T986	T984	arg3Of	),(
R769	T987	T988	arg1Of	A3G,is
R770	T987	T989	arg2Of	A3G,packaged
R771	T987	T994	arg1Of	A3G,causes
R772	T989	T988	arg2Of	packaged,is
R773	T989	T990	arg1Of	packaged,into
R774	T989	T993	arg1Of	packaged,and
R775	T992	T990	arg2Of	particles,into
R776	T992	T991	arg1Of	particles,HIV-1Δvif
R777	T994	T993	arg2Of	causes,and
R778	T994	T1002	arg1Of	causes,during
R779	T996	T994	arg2Of	deaminations,causes
R780	T996	T995	arg1Of	deaminations,C-to-U
R781	T996	T997	arg1Of	deaminations,on
R782	T1001	T997	arg2Of	DNA,on
R783	T1001	T998	arg1Of	DNA,the
R784	T1001	T999	arg1Of	DNA,single-stranded
R785	T1001	T1000	arg1Of	DNA,viral
R786	T1004	T1002	arg2Of	transcription,during
R787	T1004	T1003	arg1Of	transcription,reverse
R788	T1004	T1005	arg1Of	transcription,(
R789	T1006	T1005	arg2Of	5–8,(
R790	T1007	T1005	arg3Of	),(
R791	T1008	T1009	arg1Of	This,leads
R792	T1009	T1010	arg1Of	leads,to
R793	T1011	T1010	arg2Of	degradation,to
R794	T1011	T1012	arg1Of	degradation,of
R795	T1015	T1012	arg2Of	DNA,of
R796	T1015	T1013	arg1Of	DNA,the
R797	T1015	T1014	arg1Of	DNA,uracile-containing
R798	T1015	T1016	arg1Of	DNA,by
R799	T1015	T1021	arg1Of	DNA,to
R800	T1016	T1020	arg1Of	by,or
R801	T1019	T1016	arg2Of	mechanisms,by
R802	T1019	T1017	arg1Of	mechanisms,cellular
R803	T1019	T1018	arg1Of	mechanisms,repair
R804	T1021	T1020	arg2Of	to,or
R805	T1022	T1021	arg2Of	hypermutation,to
R806	T1022	T1023	arg1Of	hypermutation,of
R807	T1026	T1023	arg2Of	genome,of
R808	T1026	T1024	arg1Of	genome,the
R809	T1026	T1025	arg1Of	genome,viral
R810	T1026	T1027	arg1Of	genome,(
R811	T1028	T1027	arg2Of	"5,6",(
R812	T1029	T1027	arg3Of	),(
R813	T1032	T1030	arg2Of	result,As
R814	T1032	T1031	arg1Of	result,a
R815	T1037	T1034	arg1Of	fraction,only
R816	T1037	T1035	arg1Of	fraction,a
R817	T1037	T1036	arg1Of	fraction,marginal
R818	T1037	T1038	arg1Of	fraction,of
R819	T1037	T1043	arg1Of	fraction,is
R820	T1037	T1044	arg1Of	fraction,able
R821	T1037	T1046	arg1Of	fraction,complete
R822	T1042	T1038	arg2Of	particles,of
R823	T1042	T1039	arg1Of	particles,the
R824	T1042	T1040	arg1Of	particles,A3G-containing
R825	T1042	T1041	arg1Of	particles,HIV-1
R826	T1043	T1030	arg1Of	is,As
R827	T1043	T1033	arg1Of	is,","
R828	T1044	T1043	arg2Of	able,is
R829	T1046	T1044	arg2Of	complete,able
R830	T1046	T1045	arg1Of	complete,to
R831	T1049	T1046	arg2Of	cycle,complete
R832	T1049	T1047	arg1Of	cycle,the
R833	T1049	T1048	arg1Of	cycle,replication
R834	T1050	T1052	arg1Of	In,to
R835	T1051	T1050	arg2Of	addition,In
R836	T1054	T1050	arg3Of	inhibition,In
R837	T1054	T1053	arg1Of	inhibition,the
R838	T1054	T1055	arg1Of	inhibition,of
R839	T1056	T1055	arg2Of	HIV-1,of
R840	T1058	T1059	arg1Of	A3G,restricts
R841	T1059	T1050	arg1Of	restricts,In
R842	T1059	T1057	arg1Of	restricts,","
R843	T1060	T1059	arg2Of	replication,restricts
R844	T1060	T1061	arg1Of	replication,of
R845	T1063	T1062	arg1Of	lentiviruses,other
R846	T1063	T1064	arg1Of	lentiviruses,","
R847	T1064	T1066	arg1Of	",",","
R848	T1065	T1064	arg2Of	gammaretroviruses,","
R849	T1066	T1068	arg1Of	",",","
R850	T1067	T1066	arg2Of	deltaretroviruses,","
R851	T1068	T1061	arg2Of	",",of
R852	T1068	T1070	arg1Of	",",","
R853	T1069	T1068	arg2Of	spumaviruses,","
R854	T1071	T1070	arg2Of	long-terminal-repeat,","
R855	T1071	T1072	arg1Of	long-terminal-repeat,(
R856	T1073	T1072	arg2Of	LTR,(
R857	T1074	T1072	arg3Of	),(
R858	T1075	T1076	arg1Of	-retrotransposons,","
R859	T1076	T1078	arg1Of	",",and
R860	T1077	T1076	arg2Of	orthohepadnaviruses,","
R861	T1078	T1059	arg3Of	and,restricts
R862	T1078	T1080	arg1Of	and,(
R863	T1079	T1078	arg2Of	avihepadnaviruses,and
R864	T1081	T1080	arg2Of	9–21,(
R865	T1082	T1080	arg3Of	),(
R866	T1085	T1086	arg1Of	deamination,seems
R867	T1085	T1089	arg1Of	deamination,be
R868	T1086	T1083	arg1Of	seems,Interestingly
R869	T1086	T1084	arg1Of	seems,","
R870	T1086	T1095	arg1Of	seems,;
R871	T1089	T1086	arg2Of	be,seems
R872	T1089	T1087	arg1Of	be,not
R873	T1089	T1088	arg1Of	be,to
R874	T1094	T1089	arg2Of	mechanism,be
R875	T1094	T1090	arg1Of	mechanism,the
R876	T1094	T1091	arg1Of	mechanism,only
R877	T1094	T1092	arg1Of	mechanism,A3G-mediated
R878	T1094	T1093	arg1Of	mechanism,antiviral
R879	T1098	T1096	arg2Of	case,in
R880	T1098	T1097	arg1Of	case,the
R881	T1098	T1099	arg1Of	case,of
R882	T1102	T1100	arg1Of	virus,hepatitis
R883	T1102	T1101	arg1Of	virus,B
R884	T1102	T1103	arg1Of	virus,(
R885	T1102	T1106	arg1Of	virus,and
R886	T1104	T1103	arg2Of	HBV,(
R887	T1105	T1103	arg3Of	),(
R888	T1106	T1099	arg2Of	and,of
R889	T1112	T1106	arg2Of	type,and
R890	T1112	T1107	arg1Of	type,human
R891	T1112	T1108	arg1Of	type,T
R892	T1112	T1109	arg1Of	type,cell
R893	T1112	T1110	arg1Of	type,leukemia
R894	T1112	T1111	arg1Of	type,virus
R895	T1112	T1113	arg1Of	type,1
R896	T1112	T1114	arg1Of	type,(
R897	T1115	T1114	arg2Of	HTLV-1,(
R898	T1116	T1114	arg3Of	),(
R899	T1118	T1119	arg1Of	A3G,was
R900	T1118	T1120	arg2Of	A3G,shown
R901	T1118	T1122	arg1Of	A3G,restrict
R902	T1120	T1095	arg2Of	shown,;
R903	T1120	T1096	arg1Of	shown,in
R904	T1120	T1117	arg1Of	shown,","
R905	T1120	T1119	arg2Of	shown,was
R906	T1122	T1120	arg3Of	restrict,shown
R907	T1122	T1121	arg1Of	restrict,to
R908	T1122	T1125	arg1Of	restrict,by
R909	T1124	T1122	arg2Of	replication,restrict
R910	T1124	T1123	arg1Of	replication,virus
R911	T1127	T1125	arg2Of	mechanisms,by
R912	T1127	T1126	arg1Of	mechanisms,deamination-independent
R913	T1127	T1128	arg1Of	mechanisms,(
R914	T1129	T1130	arg1Of	12,","
R915	T1130	T1132	arg1Of	",",","
R916	T1131	T1130	arg2Of	13,","
R917	T1132	T1128	arg2Of	",",(
R918	T1132	T1134	arg1Of	",",","
R919	T1133	T1132	arg2Of	19,","
R920	T1135	T1134	arg2Of	22–25,","
R921	T1136	T1128	arg3Of	),(
R922	T1138	T1137	arg1Of	member,Another
R923	T1138	T1139	arg1Of	member,of
R924	T1138	T1143	arg1Of	member,","
R925	T1138	T1149	arg1Of	member,appears
R926	T1138	T1151	arg1Of	member,have
R927	T1142	T1139	arg2Of	family,of
R928	T1142	T1140	arg1Of	family,the
R929	T1142	T1141	arg1Of	family,APOBEC3
R930	T1144	T1143	arg2Of	APOBEC3F,","
R931	T1144	T1145	arg1Of	APOBEC3F,(
R932	T1146	T1145	arg2Of	A3F,(
R933	T1147	T1145	arg3Of	),(
R934	T1149	T1148	arg1Of	appears,","
R935	T1151	T1149	arg2Of	have,appears
R936	T1151	T1150	arg1Of	have,to
R937	T1153	T1151	arg2Of	activities,have
R938	T1153	T1152	arg1Of	activities,similar
R939	T1153	T1154	arg1Of	activities,like
R940	T1155	T1154	arg2Of	A3G,like
R941	T1155	T1156	arg1Of	A3G,(
R942	T1157	T1156	arg2Of	"26,27",(
R943	T1158	T1156	arg3Of	),(
R944	T1159	T1160	arg1Of	A3F,is
R945	T1159	T1162	arg2Of	A3F,packaged
R946	T1159	T1167	arg1Of	A3F,induces
R947	T1162	T1160	arg2Of	packaged,is
R948	T1162	T1161	arg1Of	packaged,also
R949	T1162	T1163	arg1Of	packaged,into
R950	T1162	T1166	arg1Of	packaged,and
R951	T1165	T1163	arg2Of	particles,into
R952	T1165	T1164	arg1Of	particles,HIV-1Δvif
R953	T1167	T1166	arg2Of	induces,and
R954	T1167	T1171	arg1Of	induces,","
R955	T1167	T1172	arg1Of	induces,although
R956	T1170	T1167	arg2Of	deaminations,induces
R957	T1170	T1168	arg1Of	deaminations,similar
R958	T1170	T1169	arg1Of	deaminations,C-to-U
R959	T1174	T1173	arg1Of	proteins,the
R960	T1174	T1175	arg1Of	proteins,differ
R961	T1175	T1172	arg2Of	differ,although
R962	T1175	T1176	arg1Of	differ,in
R963	T1180	T1176	arg2Of	specificity,in
R964	T1180	T1177	arg1Of	specificity,their
R965	T1180	T1178	arg1Of	specificity,target
R966	T1180	T1179	arg1Of	specificity,sequences
R967	T1180	T1181	arg1Of	specificity,(
R968	T1182	T1181	arg2Of	"26,28",(
R969	T1183	T1181	arg3Of	),(
R970	T1187	T1186	arg1Of	proteins,A3F
R971	T1187	T1188	arg1Of	proteins,were
R972	T1187	T1189	arg2Of	proteins,detected
R973	T1189	T1184	arg1Of	detected,Furthermore
R974	T1189	T1185	arg1Of	detected,","
R975	T1189	T1188	arg2Of	detected,were
R976	T1189	T1190	arg1Of	detected,in
R977	T1192	T1190	arg2Of	tissues,in
R978	T1192	T1191	arg1Of	tissues,many
R979	T1192	T1193	arg1Of	tissues,that
R980	T1192	T1194	arg1Of	tissues,express
R981	T1192	T1197	arg1Of	tissues,are
R982	T1192	T1198	arg1Of	tissues,able
R983	T1192	T1200	arg1Of	tissues,form
R984	T1194	T1196	arg1Of	express,and
R985	T1195	T1194	arg2Of	A3G,express
R986	T1197	T1196	arg2Of	are,and
R987	T1198	T1197	arg2Of	able,are
R988	T1200	T1198	arg2Of	form,able
R989	T1200	T1199	arg1Of	form,to
R990	T1200	T1202	arg1Of	form,with
R991	T1201	T1200	arg2Of	heteromultimers,form
R992	T1203	T1202	arg2Of	A3G,with
R993	T1203	T1204	arg1Of	A3G,(
R994	T1205	T1204	arg2Of	"26,29,30",(
R995	T1206	T1204	arg3Of	),(
R996	T1208	T1207	arg1Of	proteins,Both
R997	T1208	T1209	arg1Of	proteins,localize
R998	T1209	T1210	arg1Of	localize,to
R999	T1212	T1210	arg2Of	processing,to
R1000	T1212	T1211	arg1Of	processing,mRNA
R1001	T1212	T1213	arg1Of	processing,(
R1002	T1214	T1213	arg2Of	P,(
R1003	T1215	T1213	arg3Of	),(
R1004	T1216	T1209	arg2Of	bodies,localize
R1005	T1216	T1217	arg1Of	bodies,","
R1006	T1219	T1217	arg2Of	compartments,","
R1007	T1219	T1218	arg1Of	compartments,cytoplasmic
R1008	T1219	T1220	arg2Of	compartments,involved
R1009	T1220	T1221	arg1Of	involved,in
R1010	T1223	T1224	arg1Of	degradation,and
R1011	T1224	T1221	arg2Of	and,in
R1012	T1224	T1222	arg1Of	and,the
R1013	T1224	T1226	arg1Of	and,of
R1014	T1225	T1224	arg2Of	storage,and
R1015	T1228	T1226	arg2Of	mRNAs,of
R1016	T1228	T1227	arg1Of	mRNAs,non-translating
R1017	T1228	T1229	arg1Of	mRNAs,(
R1018	T1230	T1229	arg2Of	"30,31",(
R1019	T1231	T1229	arg3Of	),(
R1020	T1232	T1233	arg1Of	A3G,has
R1021	T1232	T1234	arg1Of	A3G,been
R1022	T1232	T1235	arg2Of	A3G,shown
R1023	T1232	T1237	arg1Of	A3G,be
R1024	T1232	T1238	arg2Of	A3G,expressed
R1025	T1235	T1233	arg2Of	shown,has
R1026	T1235	T1234	arg2Of	shown,been
R1027	T1235	T1252	arg1Of	shown,but
R1028	T1238	T1235	arg3Of	expressed,shown
R1029	T1238	T1236	arg1Of	expressed,to
R1030	T1238	T1237	arg2Of	expressed,be
R1031	T1238	T1239	arg1Of	expressed,in
R1032	T1241	T1239	arg2Of	cells,in
R1033	T1241	T1240	arg1Of	cells,T
R1034	T1241	T1242	arg1Of	cells,","
R1035	T1246	T1242	arg2Of	target,","
R1036	T1246	T1243	arg1Of	target,a
R1037	T1246	T1244	arg1Of	target,relevant
R1038	T1246	T1245	arg1Of	target,cell
R1039	T1246	T1247	arg1Of	target,for
R1040	T1248	T1247	arg2Of	HIV-1,for
R1041	T1248	T1250	arg1Of	HIV-1,vivo
R1042	T1250	T1249	arg1Of	vivo,in
R1043	T1252	T1251	arg1Of	but,","
R1044	T1253	T1254	arg1Of	little,is
R1045	T1253	T1255	arg2Of	little,known
R1046	T1255	T1252	arg2Of	known,but
R1047	T1255	T1254	arg2Of	known,is
R1048	T1255	T1256	arg1Of	known,about
R1049	T1258	T1256	arg2Of	regulation,about
R1050	T1258	T1257	arg1Of	regulation,its
R1051	T1258	T1259	arg1Of	regulation,(
R1052	T1260	T1259	arg2Of	"4,29,32",(
R1053	T1261	T1259	arg3Of	),(
R1054	T1262	T1263	arg1Of	There,is
R1055	T1263	T1266	modOf	is,describing
R1056	T1263	T1278	arg1Of	is,but
R1057	T1265	T1264	arg1Of	report,a
R1058	T1265	T1266	arg1Of	report,describing
R1059	T1269	T1266	arg2Of	stimulation,describing
R1060	T1269	T1267	arg1Of	stimulation,that
R1061	T1269	T1268	arg1Of	stimulation,mitogenic
R1062	T1269	T1270	arg1Of	stimulation,of
R1063	T1272	T1270	arg2Of	cells,of
R1064	T1272	T1271	arg1Of	cells,T
R1065	T1276	T1263	arg2Of	levels,is
R1066	T1276	T1273	arg1Of	levels,upregulates
R1067	T1276	T1274	arg1Of	levels,A3G
R1068	T1276	T1275	arg1Of	levels,mRNA
R1069	T1278	T1277	arg1Of	but,","
R1070	T1279	T1280	arg1Of	this,was
R1071	T1279	T1282	arg2Of	this,analyzed
R1072	T1282	T1278	arg2Of	analyzed,but
R1073	T1282	T1280	arg2Of	analyzed,was
R1074	T1282	T1281	arg1Of	analyzed,not
R1075	T1282	T1283	arg1Of	analyzed,on
R1076	T1286	T1283	arg2Of	level,on
R1077	T1286	T1284	arg1Of	level,the
R1078	T1286	T1285	arg1Of	level,transcriptional
R1079	T1286	T1287	arg1Of	level,(
R1080	T1288	T1287	arg2Of	33,(
R1081	T1289	T1287	arg3Of	),(
R1082	T1293	T1291	arg1Of	promoter,the
R1083	T1293	T1292	arg1Of	promoter,A3G
R1084	T1293	T1294	arg1Of	promoter,has
R1085	T1293	T1296	arg1Of	promoter,been
R1086	T1293	T1298	arg2Of	promoter,analyzed
R1087	T1298	T1290	arg2Of	analyzed,Since
R1088	T1298	T1294	arg2Of	analyzed,has
R1089	T1298	T1295	arg1Of	analyzed,not
R1090	T1298	T1296	arg2Of	analyzed,been
R1091	T1298	T1297	arg1Of	analyzed,systematically
R1092	T1298	T1300	arg1Of	analyzed,far
R1093	T1300	T1299	arg1Of	far,so
R1094	T1303	T1302	arg1Of	aim,our
R1095	T1303	T1304	arg1Of	aim,was
R1096	T1304	T1290	arg1Of	was,Since
R1097	T1304	T1301	arg1Of	was,","
R1098	T1306	T1310	arg1Of	clone,and
R1099	T1309	T1306	arg2Of	promoter,clone
R1100	T1309	T1307	arg1Of	promoter,the
R1101	T1309	T1308	arg1Of	promoter,A3G
R1102	T1310	T1304	arg2Of	and,was
R1103	T1310	T1305	arg1Of	and,to
R1104	T1311	T1310	arg2Of	characterize,and
R1105	T1313	T1311	arg2Of	regulation,characterize
R1106	T1313	T1312	arg1Of	regulation,its
R1107	T1313	T1314	arg1Of	regulation,in
R1108	T1316	T1314	arg2Of	cells,in
R1109	T1316	T1315	arg1Of	cells,T
R1110	T1319	T1317	arg2Of	study,In
R1111	T1319	T1318	arg1Of	study,our
R1112	T1321	T1322	arg1Of	we,observed
R1113	T1322	T1317	arg1Of	observed,In
R1114	T1322	T1320	arg1Of	observed,","
R1115	T1324	T1325	arg1Of	A3G,uses
R1116	T1325	T1322	arg2Of	uses,observed
R1117	T1325	T1323	arg1Of	uses,that
R1118	T1329	T1325	arg2Of	sites,uses
R1119	T1329	T1326	arg1Of	sites,multiple
R1120	T1329	T1327	arg1Of	sites,transcriptional
R1121	T1329	T1328	arg1Of	sites,start
R1122	T1329	T1330	arg1Of	sites,(
R1123	T1331	T1330	arg2Of	TSS,(
R1124	T1332	T1330	arg3Of	),(
R1125	T1334	T1333	arg2Of	generating,By
R1126	T1336	T1334	arg2Of	series,generating
R1127	T1336	T1335	arg1Of	series,a
R1128	T1336	T1337	arg1Of	series,of
R1129	T1339	T1337	arg2Of	deletions,of
R1130	T1339	T1338	arg1Of	deletions,5′
R1131	T1339	T1340	arg1Of	deletions,of
R1132	T1343	T1340	arg2Of	promoter,of
R1133	T1343	T1341	arg1Of	promoter,the
R1134	T1343	T1342	arg1Of	promoter,A3G
R1135	T1345	T1334	arg1Of	we,generating
R1136	T1345	T1346	arg1Of	we,identified
R1137	T1346	T1333	arg1Of	identified,By
R1138	T1346	T1344	arg1Of	identified,","
R1139	T1353	T1346	arg2Of	transcription,identified
R1140	T1353	T1347	arg1Of	transcription,a
R1141	T1353	T1348	arg1Of	transcription,180 bp
R1142	T1353	T1349	arg1Of	transcription,region
R1143	T1353	T1350	arg1Of	transcription,that
R1144	T1353	T1351	arg2Of	transcription,mediated
R1145	T1353	T1352	arg1Of	transcription,basal
R1146	T1356	T1354	arg2Of	cells,In
R1147	T1356	T1355	arg1Of	cells,T
R1148	T1359	T1358	arg1Of	activity,transcriptional
R1149	T1359	T1360	arg1Of	activity,of
R1150	T1359	T1364	arg1Of	activity,was
R1151	T1359	T1366	arg1Of	activity,inducible
R1152	T1359	T1375	arg1Of	activity,was
R1153	T1359	T1376	arg1Of	activity,dependent
R1154	T1363	T1360	arg2Of	promoter,of
R1155	T1363	T1361	arg1Of	promoter,this
R1156	T1363	T1362	arg1Of	promoter,core
R1157	T1364	T1365	arg1Of	was,not
R1158	T1364	T1374	arg1Of	was,but
R1159	T1366	T1364	arg2Of	inducible,was
R1160	T1366	T1367	arg1Of	inducible,by
R1161	T1369	T1368	arg1Of	stimulation,mitogenic
R1162	T1369	T1370	arg1Of	stimulation,or
R1163	T1370	T1367	arg2Of	or,by
R1164	T1372	T1370	arg2Of	treatment,or
R1165	T1372	T1371	arg1Of	treatment,interferon
R1166	T1374	T1354	arg1Of	but,In
R1167	T1374	T1357	arg1Of	but,","
R1168	T1374	T1373	arg1Of	but,","
R1169	T1375	T1374	arg2Of	was,but
R1170	T1376	T1375	arg2Of	dependent,was
R1171	T1376	T1377	arg1Of	dependent,on
R1172	T1379	T1377	arg2Of	GC-box,on
R1173	T1379	T1378	arg1Of	GC-box,a
R1174	T1379	T1380	arg1Of	GC-box,which
R1175	T1379	T1381	arg1Of	GC-box,was
R1176	T1379	T1382	arg2Of	GC-box,recognized
R1177	T1382	T1381	arg2Of	recognized,was
R1178	T1387	T1385	arg2Of	protein,(
R1179	T1387	T1386	arg1Of	protein,specificity
R1180	T1388	T1385	arg3Of	),(
R1181	T1389	T1390	arg1Of	1,and
R1182	T1391	T1390	arg2Of	Sp3,and
R1183	T1393	T1382	arg1Of	factors,recognized
R1184	T1393	T1383	arg2Of	factors,by
R1185	T1393	T1384	arg1Of	factors,Sp
R1186	T1393	T1385	arg1Of	factors,(
R1187	T1393	T1389	arg1Of	factors,1
R1188	T1393	T1391	arg1Of	factors,Sp3
R1189	T1393	T1392	arg1Of	factors,transcription

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T1394	1886-1899	Anaphor	denotes	Both proteins
T1395	1768-1771	Antecedent	denotes	A3F
T1396	1824-1827	Antecedent	denotes	A3G
T1397	2154-2157	Anaphor	denotes	its
T1398	2039-2042	Antecedent	denotes	A3G
T1399	2460-2463	Anaphor	denotes	its
T1400	2434-2442	Antecedent	denotes	promoter
R1190	T1394	T1395	boundBy	Both proteins,A3F
R1191	T1394	T1396	boundBy	Both proteins,A3G
R1192	T1397	T1398	boundBy	its,A3G
R1193	T1399	T1400	boundBy	its,promoter

events-check-again

Id	Subject	Object	Predicate	Lexical cue
T2231	186-194	Protein	denotes	APOBEC3A
T2232	196-197	Protein	denotes	B
T2233	199-200	Protein	denotes	C
T2234	202-204	Protein	denotes	DE
T2235	206-207	Protein	denotes	F
T2236	209-210	Protein	denotes	G
T2237	212-213	Protein	denotes	H
T2238	302-310	Protein	denotes	APOBEC3G
T2239	312-315	Protein	denotes	A3G
T2240	459-484	Protein	denotes	virion infectivity factor
T2241	486-489	Protein	denotes	Vif
T2242	491-498	Negative_regulation	denotes	deleted
T2243	579-582	Protein	denotes	A3G
T2244	606-609	Protein	denotes	vif
T2245	898-901	Protein	denotes	A3G
T2246	1012-1015	Protein	denotes	A3G
T2247	1260-1263	Protein	denotes	A3G
T2248	1382-1385	Protein	denotes	A3G
T2249	1523-1531	Protein	denotes	APOBEC3F
T2250	1533-1536	Protein	denotes	A3F
T2251	1579-1582	Protein	denotes	A3G
T2252	1592-1595	Protein	denotes	A3F
T2253	1624-1627	Protein	denotes	vif
T2254	1768-1771	Protein	denotes	A3F
T2255	1816-1823	Gene_expression	denotes	express
T2256	1816-1823	Gene_expression	denotes	express
T2257	1824-1827	Protein	denotes	A3G
T2258	1844-1864	Binding	denotes	form heteromultimers
T2259	1870-1873	Protein	denotes	A3G
T2260	1900-1908	Localization	denotes	localize
T2261	1900-1908	Localization	denotes	localize
T2262	1912-1938	Entity	denotes	mRNA processing (P) bodies
T2263	2039-2042	Protein	denotes	A3G
T2264	2064-2073	Gene_expression	denotes	expressed
T2265	2158-2168	Regulation	denotes	regulation
T2266	2247-2258	Positive_regulation	denotes	upregulates
T2267	2259-2262	Protein	denotes	A3G
T2268	2263-2274	Gene_expression	denotes	mRNA levels
T2269	2347-2350	Protein	denotes	A3G
T2270	2430-2433	Protein	denotes	A3G
T2271	2434-2442	Entity	denotes	promoter
T2272	2464-2474	Regulation	denotes	regulation
T2273	2518-2521	Protein	denotes	A3G
T2274	2617-2620	Protein	denotes	A3G
T2275	2801-2811	Protein	denotes	interferon
T2276	2846-2852	Entity	denotes	GC-box
T2277	2863-2873	Binding	denotes	recognized
T2278	2863-2873	Binding	denotes	recognized
T2279	2877-2903	Protein	denotes	Sp (specificity protein) 1
T2280	2908-2911	Protein	denotes	Sp3
R1828	T2239	T2238	equivalentTo	A3G,APOBEC3G
R1832	T2241	T2240	equivalentTo	Vif,virion infectivity factor
R1836	T2254	T2256	themeOf	A3F,express
R1837	T2254	T2258	themeOf	A3F,form heteromultimers
R1838	T2254	T2260	themeOf	A3F,localize
R1839	T2257	T2255	themeOf	A3G,express
R1840	T2257	T2261	themeOf	A3G,localize
R1841	T2259	T2258	themeOf	A3G,form heteromultimers
R1843	T2262	T2260	locationOf	mRNA processing (P) bodies,localize
R1844	T2262	T2261	locationOf	mRNA processing (P) bodies,localize
R1845	T2263	T2264	themeOf	A3G,expressed
R1846	T2263	T2265	themeOf	A3G,regulation
R1848	T2267	T2268	themeOf	A3G,mRNA levels
R1849	T2268	T2266	themeOf	mRNA levels,upregulates
R1851	T2271	T2272	themeOf	promoter,regulation
R1852	T2271	T2270	partOf	promoter,A3G
R1854	T2276	T2277	themeOf	GC-box,recognized
R1855	T2276	T2274	partOf	GC-box,A3G
R1856	T2276	T2278	themeOf	GC-box,recognized
R1858	T2279	T2277	themeOf	Sp (specificity protein) 1,recognized
R1859	T2280	T2278	themeOf	Sp3,recognized
R1831	T2240	T2242	themeOf	virion infectivity factor,deleted
R1835	T2250	T2249	equivalentTo	A3F,APOBEC3F

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T2281	37-51	Protein	denotes	APOBEC3 family
T2282	55-74	Protein	denotes	cytidine deaminases
T2283	296-310	Protein	denotes	Human APOBEC3G
T2284	312-315	Protein	denotes	A3G
T2285	351-365	Protein	denotes	APOBEC3 family
T2286	1382-1385	Protein	denotes	A3G
T2287	1507-1521	Protein	denotes	APOBEC3 family
T2288	1523-1531	Protein	denotes	APOBEC3F
T2289	1533-1536	Protein	denotes	A3F
T2290	1592-1595	Protein	denotes	A3F
T2291	1768-1780	Protein	denotes	A3F proteins
T2292	1824-1827	Protein	denotes	A3G
T2293	1816-1823	Gene_expression	denotes	express
T2294	1849-1864	Binding	denotes	heteromultimers
T2295	2039-2042	Protein	denotes	A3G
T2296	2064-2073	Gene_expression	denotes	expressed
T2297	2158-2168	Regulation	denotes	regulation
T2298	2259-2267	Protein	denotes	A3G mRNA
T2299	2247-2258	Positive_regulation	denotes	upregulates
T2300	2347-2359	Protein	denotes	A3G promoter
T2301	2430-2442	Protein	denotes	A3G promoter
T2302	2464-2474	Regulation	denotes	regulation
T2303	2617-2629	Protein	denotes	A3G promoter
T2304	2877-2903	Protein	denotes	Sp (specificity protein) 1
T2305	2908-2933	Protein	denotes	Sp3 transcription factors
T2306	2846-2852	Entity	denotes	GC-box
T2307	2863-2873	Binding	denotes	recognized
T2308	2863-2873	Binding	denotes	recognized
R1834	T2291	T2294	themeOf	A3F proteins,heteromultimers
R1842	T2292	T2293	themeOf	A3G,express
R1847	T2295	T2296	themeOf	A3G,expressed
R1850	T2295	T2297	themeOf	A3G,regulation
R1853	T2298	T2299	themeOf	A3G mRNA,upregulates
R1857	T2301	T2302	themeOf	A3G promoter,regulation
R1860	T2304	T2307	themeOf	Sp (specificity protein) 1,recognized
R1861	T2305	T2308	themeOf	Sp3 transcription factors,recognized
R1862	T2306	T2307	Site	GC-box,recognized
R1863	T2306	T2308	Site	GC-box,recognized

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue
T798	186-194	Protein	denotes	APOBEC3A
T799	196-197	Protein	denotes	B
T800	199-200	Protein	denotes	C
T801	202-204	Protein	denotes	DE
T802	206-207	Protein	denotes	F
T803	209-210	Protein	denotes	G
T804	212-213	Protein	denotes	H
T805	302-310	Protein	denotes	APOBEC3G
T806	312-315	Protein	denotes	A3G
T807	459-484	Protein	denotes	virion infectivity factor
T808	486-489	Protein	denotes	Vif
T809	491-498	Negative_regulation	denotes	deleted
T810	579-582	Protein	denotes	A3G
T811	606-609	Protein	denotes	vif
T812	898-901	Protein	denotes	A3G
T813	1012-1015	Protein	denotes	A3G
T814	1260-1263	Protein	denotes	A3G
T815	1382-1385	Protein	denotes	A3G
T816	1523-1531	Protein	denotes	APOBEC3F
T817	1533-1536	Protein	denotes	A3F
T818	1579-1582	Protein	denotes	A3G
T819	1592-1595	Protein	denotes	A3F
T820	1624-1627	Protein	denotes	vif
T821	1768-1771	Protein	denotes	A3F
T822	1816-1823	Gene_expression	denotes	express
T823	1816-1823	Gene_expression	denotes	express
T824	1824-1827	Protein	denotes	A3G
T825	1844-1864	Binding	denotes	form heteromultimers
T826	1870-1873	Protein	denotes	A3G
T827	1900-1908	Localization	denotes	localize
T828	1900-1908	Localization	denotes	localize
T829	1912-1938	Entity	denotes	mRNA processing (P) bodies
T830	2039-2042	Protein	denotes	A3G
T831	2064-2073	Gene_expression	denotes	expressed
T832	2158-2168	Regulation	denotes	regulation
T833	2247-2258	Positive_regulation	denotes	upregulates
T834	2259-2262	Protein	denotes	A3G
T835	2263-2274	Gene_expression	denotes	mRNA levels
T836	2347-2350	Protein	denotes	A3G
T837	2430-2433	Protein	denotes	A3G
T838	2434-2442	Entity	denotes	promoter
T839	2464-2474	Regulation	denotes	regulation
T840	2518-2521	Protein	denotes	A3G
T841	2617-2620	Protein	denotes	A3G
T842	2801-2811	Protein	denotes	interferon
T843	2846-2852	Entity	denotes	GC-box
T844	2863-2873	Binding	denotes	recognized
T845	2863-2873	Binding	denotes	recognized
T846	2877-2903	Protein	denotes	Sp (specificity protein) 1
T847	2908-2911	Protein	denotes	Sp3
R635	T806	T805	equivalentTo	A3G,APOBEC3G
R636	T807	T809	themeOf	virion infectivity factor,deleted
R637	T808	T807	equivalentTo	Vif,virion infectivity factor
R638	T817	T816	equivalentTo	A3F,APOBEC3F
R639	T821	T823	themeOf	A3F,express
R640	T821	T825	themeOf	A3F,form heteromultimers
R641	T821	T827	themeOf	A3F,localize
R642	T824	T822	themeOf	A3G,express
R643	T824	T828	themeOf	A3G,localize
R644	T826	T825	themeOf	A3G,form heteromultimers
R645	T829	T827	locationOf	mRNA processing (P) bodies,localize
R646	T829	T828	locationOf	mRNA processing (P) bodies,localize
R647	T830	T831	themeOf	A3G,expressed
R648	T830	T832	themeOf	A3G,regulation
R649	T834	T835	themeOf	A3G,mRNA levels
R650	T835	T833	themeOf	mRNA levels,upregulates
R651	T838	T839	themeOf	promoter,regulation
R652	T838	T837	partOf	promoter,A3G
R653	T843	T844	themeOf	GC-box,recognized
R654	T843	T841	partOf	GC-box,A3G
R655	T843	T845	themeOf	GC-box,recognized
R656	T846	T844	themeOf	Sp (specificity protein) 1,recognized
R657	T847	T845	themeOf	Sp3,recognized

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T1401	302-310	Q9HC16	denotes	APOBEC3G
T1402	312-315	Q9HC16	denotes	A3G
T1403	459-484	P12504	denotes	virion infectivity factor
T1404	486-489	P12504	denotes	Vif
T1405	579-582	Q9HC16	denotes	A3G
T1406	898-901	Q9HC16	denotes	A3G
T1407	932-936	P00519	denotes	able
T1408	1012-1015	Q9HC16	denotes	A3G
T1409	1260-1263	Q9HC16	denotes	A3G
T1410	1382-1385	Q9HC16	denotes	A3G
T1411	1523-1531	Q8IUX4	denotes	APOBEC3F
T1412	1533-1536	Q8IUX4	denotes	A3F
T1413	1579-1582	Q9HC16	denotes	A3G
T1414	1592-1595	Q8IUX4	denotes	A3F
T1415	1768-1771	Q8IUX4	denotes	A3F
T1416	1824-1827	Q9HC16	denotes	A3G
T1417	1836-1840	P00519	denotes	able
T1418	1870-1873	Q9HC16	denotes	A3G
T1419	2039-2042	Q9HC16	denotes	A3G
T1420	2259-2262	Q9HC16	denotes	A3G
T1421	2347-2350	Q9HC16	denotes	A3G
T1422	2409-2412	P26358	denotes	aim
T1423	2430-2433	Q9HC16	denotes	A3G
T1424	2518-2521	Q9HC16	denotes	A3G
T1425	2617-2620	Q9HC16	denotes	A3G
T1426	2908-2911	Q02447	denotes	Sp3

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