Id |
Subject |
Object |
Predicate |
Lexical cue |
T4340 |
0-10 |
VBG |
denotes |
Activating |
T4341 |
25-32 |
VB |
denotes |
promote |
T4342 |
11-15 |
NNS |
denotes |
E2fs |
T4343 |
16-19 |
MD |
denotes |
may |
T4344 |
20-24 |
RB |
denotes |
also |
T4345 |
33-42 |
NN |
denotes |
apoptosis |
T4346 |
43-45 |
IN |
denotes |
in |
T4347 |
46-49 |
DT |
denotes |
the |
T4348 |
56-62 |
NN |
denotes |
retina |
T4349 |
50-52 |
NN |
denotes |
Rb |
T4350 |
53-55 |
NN |
denotes |
KO |
T4351 |
63-64 |
-LRB- |
denotes |
( |
T4352 |
71-73 |
NN |
denotes |
1B |
T4353 |
64-70 |
NN |
denotes |
Figure |
T4354 |
73-74 |
-RRB- |
denotes |
) |
T4355 |
74-75 |
. |
denotes |
. |
T4356 |
75-160 |
sentence |
denotes |
Originally, E2f1 was considered the primary pro-apoptotic member of the family [10]. |
T4357 |
76-86 |
RB |
denotes |
Originally |
T4358 |
97-107 |
VBN |
denotes |
considered |
T4359 |
86-88 |
, |
denotes |
, |
T4360 |
88-92 |
NN |
denotes |
E2f1 |
T4361 |
93-96 |
VBD |
denotes |
was |
T4362 |
108-111 |
DT |
denotes |
the |
T4363 |
134-140 |
NN |
denotes |
member |
T4364 |
112-119 |
JJ |
denotes |
primary |
T4365 |
120-133 |
JJ |
denotes |
pro-apoptotic |
T4366 |
141-143 |
IN |
denotes |
of |
T4367 |
144-147 |
DT |
denotes |
the |
T4368 |
148-154 |
NN |
denotes |
family |
T4369 |
155-156 |
-LRB- |
denotes |
[ |
T4370 |
156-158 |
CD |
denotes |
10 |
T4371 |
158-159 |
-RRB- |
denotes |
] |
T4372 |
159-160 |
. |
denotes |
. |
T4373 |
160-337 |
sentence |
denotes |
However, this view was reevaluated when it was shown that either E2f1 or E2f3 deletion rescues apoptosis in the developing central nervous system (CNS) of Rb KO embryos [6,11]. |
T4374 |
161-168 |
RB |
denotes |
However |
T4375 |
184-195 |
VBN |
denotes |
reevaluated |
T4376 |
168-170 |
, |
denotes |
, |
T4377 |
170-174 |
DT |
denotes |
this |
T4378 |
175-179 |
NN |
denotes |
view |
T4379 |
180-183 |
VBD |
denotes |
was |
T4380 |
196-200 |
WRB |
denotes |
when |
T4381 |
208-213 |
VBN |
denotes |
shown |
T4382 |
201-203 |
PRP |
denotes |
it |
T4383 |
204-207 |
VBD |
denotes |
was |
T4384 |
214-218 |
IN |
denotes |
that |
T4385 |
248-255 |
VBZ |
denotes |
rescues |
T4386 |
219-225 |
CC |
denotes |
either |
T4387 |
226-230 |
NN |
denotes |
E2f1 |
T4388 |
239-247 |
NN |
denotes |
deletion |
T4389 |
231-233 |
CC |
denotes |
or |
T4390 |
234-238 |
NN |
denotes |
E2f3 |
T4391 |
256-265 |
NN |
denotes |
apoptosis |
T4392 |
266-268 |
IN |
denotes |
in |
T4393 |
269-272 |
DT |
denotes |
the |
T4394 |
300-306 |
NN |
denotes |
system |
T4395 |
273-283 |
VBG |
denotes |
developing |
T4396 |
284-291 |
JJ |
denotes |
central |
T4397 |
292-299 |
JJ |
denotes |
nervous |
T4398 |
307-308 |
-LRB- |
denotes |
( |
T4399 |
308-311 |
NN |
denotes |
CNS |
T4400 |
311-312 |
-RRB- |
denotes |
) |
T4401 |
313-315 |
IN |
denotes |
of |
T4402 |
316-318 |
NN |
denotes |
Rb |
T4403 |
319-321 |
NN |
denotes |
KO |
T4404 |
322-329 |
NNS |
denotes |
embryos |
T4405 |
330-331 |
-LRB- |
denotes |
[ |
T4406 |
333-335 |
CD |
denotes |
11 |
T4407 |
331-332 |
CD |
denotes |
6 |
T4408 |
332-333 |
, |
denotes |
, |
T4409 |
335-336 |
-RRB- |
denotes |
] |
T4410 |
336-337 |
. |
denotes |
. |
T4411 |
337-451 |
sentence |
denotes |
Subsequently, CNS apoptosis was shown to be an indirect result of placental defects and probable hypoxia [12–14]. |
T4412 |
338-350 |
RB |
denotes |
Subsequently |
T4413 |
370-375 |
VBN |
denotes |
shown |
T4414 |
350-352 |
, |
denotes |
, |
T4415 |
352-355 |
NN |
denotes |
CNS |
T4416 |
356-365 |
NN |
denotes |
apoptosis |
T4417 |
366-369 |
VBD |
denotes |
was |
T4418 |
376-378 |
TO |
denotes |
to |
T4419 |
379-381 |
VB |
denotes |
be |
T4420 |
382-384 |
DT |
denotes |
an |
T4421 |
394-400 |
NN |
denotes |
result |
T4422 |
385-393 |
JJ |
denotes |
indirect |
T4423 |
401-403 |
IN |
denotes |
of |
T4424 |
404-413 |
JJ |
denotes |
placental |
T4425 |
414-421 |
NNS |
denotes |
defects |
T4426 |
422-425 |
CC |
denotes |
and |
T4427 |
426-434 |
JJ |
denotes |
probable |
T4428 |
435-442 |
NN |
denotes |
hypoxia |
T4429 |
443-444 |
-LRB- |
denotes |
[ |
T4430 |
444-446 |
CD |
denotes |
12 |
T4431 |
446-447 |
SYM |
denotes |
– |
T4432 |
447-449 |
CD |
denotes |
14 |
T4433 |
449-450 |
-RRB- |
denotes |
] |
T4434 |
450-451 |
. |
denotes |
. |
T4435 |
451-543 |
sentence |
denotes |
Indeed, E2f3-induced apoptosis in fibroblasts has recently been shown to require E2f1 [15]. |
T4436 |
452-458 |
RB |
denotes |
Indeed |
T4437 |
516-521 |
VBN |
denotes |
shown |
T4438 |
458-460 |
, |
denotes |
, |
T4439 |
460-464 |
NN |
denotes |
E2f3 |
T4440 |
465-472 |
VBN |
denotes |
induced |
T4441 |
464-465 |
HYPH |
denotes |
- |
T4442 |
473-482 |
NN |
denotes |
apoptosis |
T4443 |
483-485 |
IN |
denotes |
in |
T4444 |
486-497 |
NNS |
denotes |
fibroblasts |
T4445 |
498-501 |
VBZ |
denotes |
has |
T4446 |
502-510 |
RB |
denotes |
recently |
T4447 |
511-515 |
VBN |
denotes |
been |
T4448 |
522-524 |
TO |
denotes |
to |
T4449 |
525-532 |
VB |
denotes |
require |
T4450 |
533-537 |
NN |
denotes |
E2f1 |
T4451 |
538-539 |
-LRB- |
denotes |
[ |
T4452 |
539-541 |
CD |
denotes |
15 |
T4453 |
541-542 |
-RRB- |
denotes |
] |
T4454 |
542-543 |
. |
denotes |
. |
T4455 |
543-632 |
sentence |
denotes |
Thus, it is controversial whether E2f3 is required for apoptosis of any Rb KO cell type. |
T4456 |
544-548 |
RB |
denotes |
Thus |
T4457 |
553-555 |
VBZ |
denotes |
is |
T4458 |
548-550 |
, |
denotes |
, |
T4459 |
550-552 |
PRP |
denotes |
it |
T4460 |
556-569 |
JJ |
denotes |
controversial |
T4461 |
570-577 |
IN |
denotes |
whether |
T4462 |
586-594 |
VBN |
denotes |
required |
T4463 |
578-582 |
NN |
denotes |
E2f3 |
T4464 |
583-585 |
VBZ |
denotes |
is |
T4465 |
595-598 |
IN |
denotes |
for |
T4466 |
599-608 |
NN |
denotes |
apoptosis |
T4467 |
609-611 |
IN |
denotes |
of |
T4468 |
612-615 |
DT |
denotes |
any |
T4469 |
627-631 |
NN |
denotes |
type |
T4470 |
616-618 |
NN |
denotes |
Rb |
T4471 |
619-621 |
NN |
denotes |
KO |
T4472 |
622-626 |
NN |
denotes |
cell |
T4473 |
631-632 |
. |
denotes |
. |
T4474 |
632-826 |
sentence |
denotes |
Determining which activating E2fs promote death in distinct Rb KO tissues requires conditional rather than germ line models of Rb deletion to avoid secondary indirect effects (such as hypoxia). |
T4475 |
633-644 |
VBG |
denotes |
Determining |
T4476 |
707-715 |
VBZ |
denotes |
requires |
T4477 |
645-650 |
WDT |
denotes |
which |
T4478 |
662-666 |
NNS |
denotes |
E2fs |
T4479 |
651-661 |
VBG |
denotes |
activating |
T4480 |
667-674 |
VBP |
denotes |
promote |
T4481 |
675-680 |
NN |
denotes |
death |
T4482 |
681-683 |
IN |
denotes |
in |
T4483 |
684-692 |
JJ |
denotes |
distinct |
T4484 |
699-706 |
NNS |
denotes |
tissues |
T4485 |
693-695 |
NN |
denotes |
Rb |
T4486 |
696-698 |
NN |
denotes |
KO |
T4487 |
716-727 |
JJ |
denotes |
conditional |
T4488 |
750-756 |
NNS |
denotes |
models |
T4489 |
728-734 |
RB |
denotes |
rather |
T4490 |
735-739 |
IN |
denotes |
than |
T4491 |
740-744 |
NN |
denotes |
germ |
T4492 |
745-749 |
NN |
denotes |
line |
T4493 |
757-759 |
IN |
denotes |
of |
T4494 |
760-762 |
NN |
denotes |
Rb |
T4495 |
763-771 |
NN |
denotes |
deletion |
T4496 |
772-774 |
TO |
denotes |
to |
T4497 |
775-780 |
VB |
denotes |
avoid |
T4498 |
781-790 |
JJ |
denotes |
secondary |
T4499 |
800-807 |
NNS |
denotes |
effects |
T4500 |
791-799 |
JJ |
denotes |
indirect |
T4501 |
808-809 |
-LRB- |
denotes |
( |
T4502 |
809-813 |
JJ |
denotes |
such |
T4503 |
814-816 |
IN |
denotes |
as |
T4504 |
817-824 |
NN |
denotes |
hypoxia |
T4505 |
824-825 |
-RRB- |
denotes |
) |
T4506 |
825-826 |
. |
denotes |
. |
R649 |
T4340 |
T4341 |
csubj |
Activating,promote |
R651 |
T4342 |
T4340 |
dobj |
E2fs,Activating |
R652 |
T4343 |
T4341 |
aux |
may,promote |
R654 |
T4344 |
T4341 |
advmod |
also,promote |
R655 |
T4345 |
T4341 |
dobj |
apoptosis,promote |
R657 |
T4346 |
T4341 |
prep |
in,promote |
R659 |
T4347 |
T4348 |
det |
the,retina |
R660 |
T4348 |
T4346 |
pobj |
retina,in |
R662 |
T4349 |
T4350 |
compound |
Rb,KO |
R663 |
T4350 |
T4348 |
compound |
KO,retina |
R664 |
T4351 |
T4352 |
punct |
(,1B |
R665 |
T4352 |
T4341 |
parataxis |
1B,promote |
R667 |
T4353 |
T4352 |
compound |
Figure,1B |
R668 |
T4354 |
T4352 |
punct |
),1B |
R669 |
T4355 |
T4341 |
punct |
.,promote |
R671 |
T4357 |
T4358 |
advmod |
Originally,considered |
R673 |
T4359 |
T4358 |
punct |
", ",considered |
R674 |
T4360 |
T4358 |
nsubjpass |
E2f1,considered |
R676 |
T4361 |
T4358 |
auxpass |
was,considered |
R677 |
T4362 |
T4363 |
det |
the,member |
R678 |
T4363 |
T4358 |
oprd |
member,considered |
R680 |
T4364 |
T4363 |
amod |
primary,member |
R681 |
T4365 |
T4363 |
amod |
pro-apoptotic,member |
R682 |
T4366 |
T4363 |
prep |
of,member |
R684 |
T4367 |
T4368 |
det |
the,family |
R685 |
T4368 |
T4366 |
pobj |
family,of |
R686 |
T4369 |
T4370 |
punct |
[,10 |
R687 |
T4370 |
T4358 |
parataxis |
10,considered |
R690 |
T4371 |
T4370 |
punct |
],10 |
R691 |
T4372 |
T4358 |
punct |
.,considered |
R693 |
T4374 |
T4375 |
advmod |
However,reevaluated |
R694 |
T4376 |
T4375 |
punct |
", ",reevaluated |
R696 |
T4377 |
T4378 |
det |
this,view |
R697 |
T4378 |
T4375 |
nsubjpass |
view,reevaluated |
R699 |
T4379 |
T4375 |
auxpass |
was,reevaluated |
R700 |
T4380 |
T4381 |
advmod |
when,shown |
R702 |
T4381 |
T4375 |
advcl |
shown,reevaluated |
R703 |
T4382 |
T4381 |
nsubjpass |
it,shown |
R704 |
T4383 |
T4381 |
auxpass |
was,shown |
R705 |
T4384 |
T4385 |
mark |
that,rescues |
R707 |
T4385 |
T4381 |
ccomp |
rescues,shown |
R708 |
T4386 |
T4387 |
preconj |
either,E2f1 |
R709 |
T4387 |
T4388 |
nmod |
E2f1,deletion |
R711 |
T4388 |
T4385 |
nsubj |
deletion,rescues |
R712 |
T4389 |
T4387 |
cc |
or,E2f1 |
R713 |
T4390 |
T4387 |
conj |
E2f3,E2f1 |
R715 |
T4391 |
T4385 |
dobj |
apoptosis,rescues |
R716 |
T4392 |
T4385 |
prep |
in,rescues |
R717 |
T4393 |
T4394 |
det |
the,system |
R719 |
T4394 |
T4392 |
pobj |
system,in |
R720 |
T4395 |
T4394 |
amod |
developing,system |
R721 |
T4396 |
T4394 |
amod |
central,system |
R723 |
T4397 |
T4394 |
amod |
nervous,system |
R724 |
T4398 |
T4394 |
punct |
(,system |
R725 |
T4399 |
T4394 |
appos |
CNS,system |
R726 |
T4400 |
T4394 |
punct |
),system |
R728 |
T4401 |
T4394 |
prep |
of,system |
R729 |
T4402 |
T4403 |
compound |
Rb,KO |
R730 |
T4403 |
T4404 |
compound |
KO,embryos |
R731 |
T4404 |
T4401 |
pobj |
embryos,of |
R733 |
T4405 |
T4406 |
punct |
[,11 |
R734 |
T4406 |
T4381 |
parataxis |
11,shown |
R735 |
T4407 |
T4406 |
nummod |
6,11 |
R737 |
T4408 |
T4406 |
punct |
",",11 |
R738 |
T4409 |
T4406 |
punct |
],11 |
R739 |
T4410 |
T4375 |
punct |
.,reevaluated |
R740 |
T4412 |
T4413 |
advmod |
Subsequently,shown |
R742 |
T4414 |
T4413 |
punct |
", ",shown |
R743 |
T4415 |
T4416 |
compound |
CNS,apoptosis |
R744 |
T4416 |
T4413 |
nsubjpass |
apoptosis,shown |
R746 |
T4417 |
T4413 |
auxpass |
was,shown |
R747 |
T4418 |
T4419 |
aux |
to,be |
R748 |
T4419 |
T4413 |
xcomp |
be,shown |
R750 |
T4420 |
T4421 |
det |
an,result |
R751 |
T4421 |
T4419 |
attr |
result,be |
R753 |
T4422 |
T4421 |
amod |
indirect,result |
R754 |
T4423 |
T4421 |
prep |
of,result |
R755 |
T4424 |
T4425 |
amod |
placental,defects |
R757 |
T4425 |
T4423 |
pobj |
defects,of |
R758 |
T4426 |
T4425 |
cc |
and,defects |
R759 |
T4427 |
T4428 |
amod |
probable,hypoxia |
R761 |
T4428 |
T4425 |
conj |
hypoxia,defects |
R762 |
T4429 |
T4430 |
punct |
[,12 |
R763 |
T4430 |
T4419 |
parataxis |
12,be |
R765 |
T4431 |
T4432 |
punct |
–,14 |
R766 |
T4432 |
T4430 |
prep |
14,12 |
R767 |
T4433 |
T4430 |
punct |
],12 |
R770 |
T4434 |
T4413 |
punct |
.,shown |
R772 |
T4436 |
T4437 |
advmod |
Indeed,shown |
R774 |
T4438 |
T4437 |
punct |
", ",shown |
R775 |
T4439 |
T4440 |
npadvmod |
E2f3,induced |
R777 |
T4440 |
T4442 |
amod |
induced,apoptosis |
R778 |
T4441 |
T4440 |
punct |
-,induced |
R779 |
T4442 |
T4437 |
nsubjpass |
apoptosis,shown |
R781 |
T4443 |
T4442 |
prep |
in,apoptosis |
R782 |
T4444 |
T4443 |
pobj |
fibroblasts,in |
R784 |
T4445 |
T4437 |
aux |
has,shown |
R785 |
T4446 |
T4437 |
advmod |
recently,shown |
R786 |
T4447 |
T4437 |
auxpass |
been,shown |
R788 |
T4448 |
T4449 |
aux |
to,require |
R789 |
T4449 |
T4437 |
xcomp |
require,shown |
R790 |
T4450 |
T4449 |
dobj |
E2f1,require |
R791 |
T4451 |
T4452 |
punct |
[,15 |
R792 |
T4452 |
T4449 |
parataxis |
15,require |
R793 |
T4453 |
T4452 |
punct |
],15 |
R795 |
T4454 |
T4437 |
punct |
.,shown |
R796 |
T4456 |
T4457 |
advmod |
Thus,is |
R798 |
T4458 |
T4457 |
punct |
", ",is |
R800 |
T4459 |
T4457 |
nsubj |
it,is |
R801 |
T4460 |
T4457 |
acomp |
controversial,is |
R802 |
T4461 |
T4462 |
mark |
whether,required |
R804 |
T4462 |
T4457 |
ccomp |
required,is |
R805 |
T4463 |
T4462 |
nsubjpass |
E2f3,required |
R806 |
T4464 |
T4462 |
auxpass |
is,required |
R808 |
T4465 |
T4462 |
prep |
for,required |
R809 |
T4466 |
T4465 |
pobj |
apoptosis,for |
R811 |
T4467 |
T4466 |
prep |
of,apoptosis |
R812 |
T4468 |
T4469 |
det |
any,type |
R813 |
T4469 |
T4467 |
pobj |
type,of |
R815 |
T4470 |
T4471 |
compound |
Rb,KO |
R816 |
T4471 |
T4469 |
compound |
KO,type |
R817 |
T4472 |
T4469 |
compound |
cell,type |
R818 |
T4473 |
T4457 |
punct |
.,is |
R820 |
T4475 |
T4476 |
csubj |
Determining,requires |
R824 |
T4477 |
T4478 |
det |
which,E2fs |
R825 |
T4478 |
T4480 |
dep |
E2fs,promote |
R826 |
T4479 |
T4478 |
amod |
activating,E2fs |
R828 |
T4480 |
T4475 |
ccomp |
promote,Determining |
R829 |
T4481 |
T4480 |
dobj |
death,promote |
R830 |
T4482 |
T4480 |
prep |
in,promote |
R832 |
T4483 |
T4484 |
amod |
distinct,tissues |
R833 |
T4484 |
T4482 |
pobj |
tissues,in |
R834 |
T4485 |
T4486 |
compound |
Rb,KO |
R836 |
T4486 |
T4484 |
compound |
KO,tissues |
R837 |
T4487 |
T4488 |
amod |
conditional,models |
R839 |
T4488 |
T4476 |
dobj |
models,requires |
R840 |
T4489 |
T4490 |
advmod |
rather,than |
R841 |
T4490 |
T4487 |
cc |
than,conditional |
R842 |
T4491 |
T4492 |
compound |
germ,line |
R843 |
T4492 |
T4487 |
conj |
line,conditional |
R844 |
T4493 |
T4488 |
prep |
of,models |
R846 |
T4494 |
T4495 |
compound |
Rb,deletion |
R847 |
T4495 |
T4493 |
pobj |
deletion,of |
R848 |
T4496 |
T4497 |
aux |
to,avoid |
R850 |
T4497 |
T4476 |
advcl |
avoid,requires |
R851 |
T4498 |
T4499 |
amod |
secondary,effects |
R852 |
T4499 |
T4497 |
dobj |
effects,avoid |
R853 |
T4500 |
T4499 |
amod |
indirect,effects |
R854 |
T4501 |
T4499 |
punct |
(,effects |
R856 |
T4502 |
T4503 |
amod |
such,as |
R857 |
T4503 |
T4499 |
prep |
as,effects |
R858 |
T4504 |
T4503 |
pobj |
hypoxia,as |
R860 |
T4505 |
T4476 |
punct |
),requires |
R861 |
T4506 |
T4476 |
punct |
.,requires |