Id |
Subject |
Object |
Predicate |
Lexical cue |
T25716 |
0-8 |
JJ |
denotes |
Distinct |
T25717 |
25-37 |
NN |
denotes |
Localization |
T25718 |
9-14 |
NN |
denotes |
E2f3a |
T25719 |
15-18 |
CC |
denotes |
and |
T25720 |
19-24 |
NN |
denotes |
E2f3b |
T25721 |
37-126 |
sentence |
denotes |
The subcellular location of E2f isoforms has not to our knowledge been addressed before. |
T25722 |
38-41 |
DT |
denotes |
The |
T25723 |
54-62 |
NN |
denotes |
location |
T25724 |
42-53 |
JJ |
denotes |
subcellular |
T25725 |
109-118 |
VBN |
denotes |
addressed |
T25726 |
63-65 |
IN |
denotes |
of |
T25727 |
66-69 |
NN |
denotes |
E2f |
T25728 |
70-78 |
NNS |
denotes |
isoforms |
T25729 |
79-82 |
VBZ |
denotes |
has |
T25730 |
83-86 |
RB |
denotes |
not |
T25731 |
87-89 |
IN |
denotes |
to |
T25732 |
90-93 |
PRP$ |
denotes |
our |
T25733 |
94-103 |
NN |
denotes |
knowledge |
T25734 |
104-108 |
VBN |
denotes |
been |
T25735 |
119-125 |
RB |
denotes |
before |
T25736 |
125-126 |
. |
denotes |
. |
T25737 |
126-348 |
sentence |
denotes |
E2f3a and E2f3b share 110 C-terminal amino acids that encode the NLS, DNA-binding, marked box, transactivation, and Rb-binding domains [16], yet they exhibit different subcellular distribution in developing retinal cells. |
T25738 |
127-132 |
NN |
denotes |
E2f3a |
T25739 |
143-148 |
VBP |
denotes |
share |
T25740 |
133-136 |
CC |
denotes |
and |
T25741 |
137-142 |
NN |
denotes |
E2f3b |
T25742 |
149-152 |
CD |
denotes |
110 |
T25743 |
170-175 |
NNS |
denotes |
acids |
T25744 |
153-154 |
NN |
denotes |
C |
T25745 |
155-163 |
JJ |
denotes |
terminal |
T25746 |
154-155 |
HYPH |
denotes |
- |
T25747 |
164-169 |
NN |
denotes |
amino |
T25748 |
176-180 |
WDT |
denotes |
that |
T25749 |
181-187 |
VBP |
denotes |
encode |
T25750 |
188-191 |
DT |
denotes |
the |
T25751 |
254-261 |
NNS |
denotes |
domains |
T25752 |
192-195 |
NN |
denotes |
NLS |
T25753 |
195-197 |
, |
denotes |
, |
T25754 |
197-200 |
NN |
denotes |
DNA |
T25755 |
200-201 |
HYPH |
denotes |
- |
T25756 |
201-208 |
VBG |
denotes |
binding |
T25757 |
208-210 |
, |
denotes |
, |
T25758 |
210-216 |
JJ |
denotes |
marked |
T25759 |
217-220 |
NN |
denotes |
box |
T25760 |
220-222 |
, |
denotes |
, |
T25761 |
222-237 |
NN |
denotes |
transactivation |
T25762 |
237-239 |
, |
denotes |
, |
T25763 |
239-242 |
CC |
denotes |
and |
T25764 |
243-245 |
NN |
denotes |
Rb |
T25765 |
245-246 |
HYPH |
denotes |
- |
T25766 |
246-253 |
VBG |
denotes |
binding |
T25767 |
262-263 |
-LRB- |
denotes |
[ |
T25768 |
263-265 |
CD |
denotes |
16 |
T25769 |
265-266 |
-RRB- |
denotes |
] |
T25770 |
266-268 |
, |
denotes |
, |
T25771 |
268-271 |
CC |
denotes |
yet |
T25772 |
272-276 |
PRP |
denotes |
they |
T25773 |
277-284 |
VBP |
denotes |
exhibit |
T25774 |
285-294 |
JJ |
denotes |
different |
T25775 |
307-319 |
NN |
denotes |
distribution |
T25776 |
295-306 |
JJ |
denotes |
subcellular |
T25777 |
320-322 |
IN |
denotes |
in |
T25778 |
323-333 |
VBG |
denotes |
developing |
T25779 |
342-347 |
NNS |
denotes |
cells |
T25780 |
334-341 |
JJ |
denotes |
retinal |
T25781 |
347-348 |
. |
denotes |
. |
T25782 |
348-416 |
sentence |
denotes |
E2f3a is both nuclear and cytoplasmic, but E2f3b is always nuclear. |
T25783 |
349-354 |
NN |
denotes |
E2f3a |
T25784 |
355-357 |
VBZ |
denotes |
is |
T25785 |
358-362 |
CC |
denotes |
both |
T25786 |
363-370 |
JJ |
denotes |
nuclear |
T25787 |
371-374 |
CC |
denotes |
and |
T25788 |
375-386 |
JJ |
denotes |
cytoplasmic |
T25789 |
386-388 |
, |
denotes |
, |
T25790 |
388-391 |
CC |
denotes |
but |
T25791 |
392-397 |
NN |
denotes |
E2f3b |
T25792 |
398-400 |
VBZ |
denotes |
is |
T25793 |
401-407 |
RB |
denotes |
always |
T25794 |
408-415 |
JJ |
denotes |
nuclear |
T25795 |
415-416 |
. |
denotes |
. |
T25796 |
416-524 |
sentence |
denotes |
The unique 121- and six-residue N-termini of E2f3a and E2f3b, respectively, likely mediate this difference. |
T25797 |
417-420 |
DT |
denotes |
The |
T25798 |
451-458 |
NNS |
denotes |
termini |
T25799 |
421-427 |
JJ |
denotes |
unique |
T25800 |
428-431 |
CD |
denotes |
121 |
T25801 |
441-448 |
NN |
denotes |
residue |
T25802 |
431-432 |
HYPH |
denotes |
- |
T25803 |
433-436 |
CC |
denotes |
and |
T25804 |
437-440 |
CD |
denotes |
six |
T25805 |
440-441 |
HYPH |
denotes |
- |
T25806 |
449-450 |
NNS |
denotes |
N |
T25807 |
450-451 |
HYPH |
denotes |
- |
T25808 |
500-507 |
VBP |
denotes |
mediate |
T25809 |
459-461 |
IN |
denotes |
of |
T25810 |
462-467 |
NN |
denotes |
E2f3a |
T25811 |
468-471 |
CC |
denotes |
and |
T25812 |
472-477 |
NN |
denotes |
E2f3b |
T25813 |
477-479 |
, |
denotes |
, |
T25814 |
479-491 |
RB |
denotes |
respectively |
T25815 |
491-493 |
, |
denotes |
, |
T25816 |
493-499 |
RB |
denotes |
likely |
T25817 |
508-512 |
DT |
denotes |
this |
T25818 |
513-523 |
NN |
denotes |
difference |
T25819 |
523-524 |
. |
denotes |
. |
T25820 |
524-665 |
sentence |
denotes |
This region in E2f1, E2f2, and E2f3a binds Ccna2, establishing a negative regulatory loop that deactivates E2fs in mid-late S-phase [64,65]. |
T25821 |
525-529 |
DT |
denotes |
This |
T25822 |
530-536 |
NN |
denotes |
region |
T25823 |
562-567 |
VBZ |
denotes |
binds |
T25824 |
537-539 |
IN |
denotes |
in |
T25825 |
540-544 |
NN |
denotes |
E2f1 |
T25826 |
544-546 |
, |
denotes |
, |
T25827 |
546-550 |
NN |
denotes |
E2f2 |
T25828 |
550-552 |
, |
denotes |
, |
T25829 |
552-555 |
CC |
denotes |
and |
T25830 |
556-561 |
NN |
denotes |
E2f3a |
T25831 |
568-573 |
NN |
denotes |
Ccna2 |
T25832 |
573-575 |
, |
denotes |
, |
T25833 |
575-587 |
VBG |
denotes |
establishing |
T25834 |
588-589 |
DT |
denotes |
a |
T25835 |
610-614 |
NN |
denotes |
loop |
T25836 |
590-598 |
JJ |
denotes |
negative |
T25837 |
599-609 |
JJ |
denotes |
regulatory |
T25838 |
615-619 |
WDT |
denotes |
that |
T25839 |
620-631 |
VBZ |
denotes |
deactivates |
T25840 |
632-636 |
NNS |
denotes |
E2fs |
T25841 |
637-639 |
IN |
denotes |
in |
T25842 |
640-643 |
JJ |
denotes |
mid |
T25843 |
644-648 |
JJ |
denotes |
late |
T25844 |
643-644 |
SYM |
denotes |
- |
T25845 |
651-656 |
NN |
denotes |
phase |
T25846 |
649-650 |
NN |
denotes |
S |
T25847 |
650-651 |
HYPH |
denotes |
- |
T25848 |
657-658 |
-LRB- |
denotes |
[ |
T25849 |
661-663 |
CD |
denotes |
65 |
T25850 |
658-660 |
CD |
denotes |
64 |
T25851 |
660-661 |
, |
denotes |
, |
T25852 |
663-664 |
-RRB- |
denotes |
] |
T25853 |
664-665 |
. |
denotes |
. |
T25854 |
665-828 |
sentence |
denotes |
However, even E2f3b, which lacks this domain, binds and is regulated by Ccna2 [18], so the domain difference may not explain the unique distributions we observed. |
T25855 |
666-673 |
RB |
denotes |
However |
T25856 |
712-717 |
VBZ |
denotes |
binds |
T25857 |
673-675 |
, |
denotes |
, |
T25858 |
675-679 |
RB |
denotes |
even |
T25859 |
680-685 |
NN |
denotes |
E2f3b |
T25860 |
685-687 |
, |
denotes |
, |
T25861 |
687-692 |
WDT |
denotes |
which |
T25862 |
693-698 |
VBZ |
denotes |
lacks |
T25863 |
699-703 |
DT |
denotes |
this |
T25864 |
704-710 |
NN |
denotes |
domain |
T25865 |
710-712 |
, |
denotes |
, |
T25866 |
718-721 |
CC |
denotes |
and |
T25867 |
722-724 |
VBZ |
denotes |
is |
T25868 |
725-734 |
VBN |
denotes |
regulated |
T25869 |
735-737 |
IN |
denotes |
by |
T25870 |
738-743 |
NN |
denotes |
Ccna2 |
T25871 |
744-745 |
-LRB- |
denotes |
[ |
T25872 |
745-747 |
CD |
denotes |
18 |
T25873 |
747-748 |
-RRB- |
denotes |
] |
T25874 |
748-750 |
, |
denotes |
, |
T25875 |
750-752 |
IN |
denotes |
so |
T25876 |
783-790 |
VB |
denotes |
explain |
T25877 |
753-756 |
DT |
denotes |
the |
T25878 |
764-774 |
NN |
denotes |
difference |
T25879 |
757-763 |
NN |
denotes |
domain |
T25880 |
775-778 |
MD |
denotes |
may |
T25881 |
779-782 |
RB |
denotes |
not |
T25882 |
791-794 |
DT |
denotes |
the |
T25883 |
802-815 |
NNS |
denotes |
distributions |
T25884 |
795-801 |
JJ |
denotes |
unique |
T25885 |
816-818 |
PRP |
denotes |
we |
T25886 |
819-827 |
VBD |
denotes |
observed |
T25887 |
827-828 |
. |
denotes |
. |
T25888 |
828-993 |
sentence |
denotes |
Rb family and Tfdp proteins can also determine E2f localization [20–22], and we found that a portion of both Rb and Tfdp1 proteins are cytoplasmic in retinal cells. |
T25889 |
829-831 |
NN |
denotes |
Rb |
T25890 |
832-838 |
NN |
denotes |
family |
T25891 |
848-856 |
NN |
denotes |
proteins |
T25892 |
839-842 |
CC |
denotes |
and |
T25893 |
843-847 |
NN |
denotes |
Tfdp |
T25894 |
866-875 |
VB |
denotes |
determine |
T25895 |
857-860 |
MD |
denotes |
can |
T25896 |
861-865 |
RB |
denotes |
also |
T25897 |
876-879 |
NN |
denotes |
E2f |
T25898 |
880-892 |
NN |
denotes |
localization |
T25899 |
893-894 |
-LRB- |
denotes |
[ |
T25900 |
894-896 |
CD |
denotes |
20 |
T25901 |
896-897 |
SYM |
denotes |
– |
T25902 |
897-899 |
CD |
denotes |
22 |
T25903 |
899-900 |
-RRB- |
denotes |
] |
T25904 |
900-902 |
, |
denotes |
, |
T25905 |
902-905 |
CC |
denotes |
and |
T25906 |
906-908 |
PRP |
denotes |
we |
T25907 |
909-914 |
VBD |
denotes |
found |
T25908 |
915-919 |
IN |
denotes |
that |
T25909 |
960-963 |
VBP |
denotes |
are |
T25910 |
920-921 |
DT |
denotes |
a |
T25911 |
922-929 |
NN |
denotes |
portion |
T25912 |
930-932 |
IN |
denotes |
of |
T25913 |
933-937 |
CC |
denotes |
both |
T25914 |
938-940 |
NN |
denotes |
Rb |
T25915 |
951-959 |
NN |
denotes |
proteins |
T25916 |
941-944 |
CC |
denotes |
and |
T25917 |
945-950 |
NN |
denotes |
Tfdp1 |
T25918 |
964-975 |
JJ |
denotes |
cytoplasmic |
T25919 |
976-978 |
IN |
denotes |
in |
T25920 |
979-986 |
JJ |
denotes |
retinal |
T25921 |
987-992 |
NNS |
denotes |
cells |
T25922 |
992-993 |
. |
denotes |
. |
T25923 |
993-1071 |
sentence |
denotes |
Indeed, immunostaining revealed that Rb and E2f3 colocalize to SAC processes. |
T25924 |
994-1000 |
RB |
denotes |
Indeed |
T25925 |
1017-1025 |
VBD |
denotes |
revealed |
T25926 |
1000-1002 |
, |
denotes |
, |
T25927 |
1002-1016 |
NN |
denotes |
immunostaining |
T25928 |
1026-1030 |
IN |
denotes |
that |
T25929 |
1043-1053 |
VBP |
denotes |
colocalize |
T25930 |
1031-1033 |
NN |
denotes |
Rb |
T25931 |
1034-1037 |
CC |
denotes |
and |
T25932 |
1038-1042 |
NN |
denotes |
E2f3 |
T25933 |
1054-1056 |
IN |
denotes |
to |
T25934 |
1057-1060 |
NN |
denotes |
SAC |
T25935 |
1061-1070 |
NNS |
denotes |
processes |
T25936 |
1070-1071 |
. |
denotes |
. |
T25937 |
1071-1274 |
sentence |
denotes |
The nuclear localization of E2f3b contrasts with that of other repressive E2fs in differentiating muscle, where E2f5 switches from the nucleus to cytoplasm, while E2f4 remains in both compartments [23]. |
T25938 |
1072-1075 |
DT |
denotes |
The |
T25939 |
1084-1096 |
NN |
denotes |
localization |
T25940 |
1076-1083 |
JJ |
denotes |
nuclear |
T25941 |
1106-1115 |
VBZ |
denotes |
contrasts |
T25942 |
1097-1099 |
IN |
denotes |
of |
T25943 |
1100-1105 |
NN |
denotes |
E2f3b |
T25944 |
1116-1120 |
IN |
denotes |
with |
T25945 |
1121-1125 |
DT |
denotes |
that |
T25946 |
1126-1128 |
IN |
denotes |
of |
T25947 |
1129-1134 |
JJ |
denotes |
other |
T25948 |
1146-1150 |
NNS |
denotes |
E2fs |
T25949 |
1135-1145 |
JJ |
denotes |
repressive |
T25950 |
1151-1153 |
IN |
denotes |
in |
T25951 |
1154-1169 |
VBG |
denotes |
differentiating |
T25952 |
1170-1176 |
NN |
denotes |
muscle |
T25953 |
1176-1178 |
, |
denotes |
, |
T25954 |
1178-1183 |
WRB |
denotes |
where |
T25955 |
1189-1197 |
VBZ |
denotes |
switches |
T25956 |
1184-1188 |
NN |
denotes |
E2f5 |
T25957 |
1198-1202 |
IN |
denotes |
from |
T25958 |
1203-1206 |
DT |
denotes |
the |
T25959 |
1207-1214 |
NN |
denotes |
nucleus |
T25960 |
1215-1217 |
IN |
denotes |
to |
T25961 |
1218-1227 |
NN |
denotes |
cytoplasm |
T25962 |
1227-1229 |
, |
denotes |
, |
T25963 |
1229-1234 |
IN |
denotes |
while |
T25964 |
1240-1247 |
VBZ |
denotes |
remains |
T25965 |
1235-1239 |
NN |
denotes |
E2f4 |
T25966 |
1248-1250 |
IN |
denotes |
in |
T25967 |
1251-1255 |
DT |
denotes |
both |
T25968 |
1256-1268 |
NNS |
denotes |
compartments |
T25969 |
1269-1270 |
-LRB- |
denotes |
[ |
T25970 |
1270-1272 |
CD |
denotes |
23 |
T25971 |
1272-1273 |
-RRB- |
denotes |
] |
T25972 |
1273-1274 |
. |
denotes |
. |
T25973 |
1274-1399 |
sentence |
denotes |
The distinct compartmentalization of E2f3a and E2f3b in the retina suggests temporally and functionally distinct activities. |
T25974 |
1275-1278 |
DT |
denotes |
The |
T25975 |
1288-1308 |
NN |
denotes |
compartmentalization |
T25976 |
1279-1287 |
JJ |
denotes |
distinct |
T25977 |
1342-1350 |
VBZ |
denotes |
suggests |
T25978 |
1309-1311 |
IN |
denotes |
of |
T25979 |
1312-1317 |
NN |
denotes |
E2f3a |
T25980 |
1318-1321 |
CC |
denotes |
and |
T25981 |
1322-1327 |
NN |
denotes |
E2f3b |
T25982 |
1328-1330 |
IN |
denotes |
in |
T25983 |
1331-1334 |
DT |
denotes |
the |
T25984 |
1335-1341 |
NN |
denotes |
retina |
T25985 |
1351-1361 |
RB |
denotes |
temporally |
T25986 |
1379-1387 |
JJ |
denotes |
distinct |
T25987 |
1362-1365 |
CC |
denotes |
and |
T25988 |
1366-1378 |
RB |
denotes |
functionally |
T25989 |
1388-1398 |
NNS |
denotes |
activities |
T25990 |
1398-1399 |
. |
denotes |
. |
T25991 |
1399-1521 |
sentence |
denotes |
Rb distribution matches that of E2f3a, consistent with its critical role in supporting SAC differentiation through E2f3a. |
T25992 |
1400-1402 |
NN |
denotes |
Rb |
T25993 |
1403-1415 |
NN |
denotes |
distribution |
T25994 |
1416-1423 |
VBZ |
denotes |
matches |
T25995 |
1424-1428 |
DT |
denotes |
that |
T25996 |
1429-1431 |
IN |
denotes |
of |
T25997 |
1432-1437 |
NN |
denotes |
E2f3a |
T25998 |
1437-1439 |
, |
denotes |
, |
T25999 |
1439-1449 |
JJ |
denotes |
consistent |
T26000 |
1450-1454 |
IN |
denotes |
with |
T26001 |
1455-1458 |
PRP$ |
denotes |
its |
T26002 |
1468-1472 |
NN |
denotes |
role |
T26003 |
1459-1467 |
JJ |
denotes |
critical |
T26004 |
1473-1475 |
IN |
denotes |
in |
T26005 |
1476-1486 |
VBG |
denotes |
supporting |
T26006 |
1487-1490 |
NN |
denotes |
SAC |
T26007 |
1491-1506 |
NN |
denotes |
differentiation |
T26008 |
1507-1514 |
IN |
denotes |
through |
T26009 |
1515-1520 |
NN |
denotes |
E2f3a |
T26010 |
1520-1521 |
. |
denotes |
. |
R7561 |
T25716 |
T25717 |
amod |
Distinct,Localization |
R7562 |
T25718 |
T25717 |
nmod |
E2f3a,Localization |
R7563 |
T25719 |
T25718 |
cc |
and,E2f3a |
R7564 |
T25720 |
T25718 |
conj |
E2f3b,E2f3a |
R7565 |
T25722 |
T25723 |
det |
The,location |
R7566 |
T25723 |
T25725 |
nsubjpass |
location,addressed |
R7567 |
T25724 |
T25723 |
amod |
subcellular,location |
R7568 |
T25726 |
T25723 |
prep |
of,location |
R7569 |
T25727 |
T25728 |
compound |
E2f,isoforms |
R7570 |
T25728 |
T25726 |
pobj |
isoforms,of |
R7571 |
T25729 |
T25725 |
aux |
has,addressed |
R7572 |
T25730 |
T25725 |
neg |
not,addressed |
R7573 |
T25731 |
T25725 |
prep |
to,addressed |
R7574 |
T25732 |
T25733 |
poss |
our,knowledge |
R7575 |
T25733 |
T25731 |
pobj |
knowledge,to |
R7576 |
T25734 |
T25725 |
auxpass |
been,addressed |
R7577 |
T25735 |
T25725 |
advmod |
before,addressed |
R7578 |
T25736 |
T25725 |
punct |
.,addressed |
R7579 |
T25738 |
T25739 |
nsubj |
E2f3a,share |
R7580 |
T25740 |
T25738 |
cc |
and,E2f3a |
R7581 |
T25741 |
T25738 |
conj |
E2f3b,E2f3a |
R7582 |
T25742 |
T25743 |
nummod |
110,acids |
R7583 |
T25743 |
T25739 |
dobj |
acids,share |
R7584 |
T25744 |
T25745 |
npadvmod |
C,terminal |
R7585 |
T25745 |
T25743 |
amod |
terminal,acids |
R7586 |
T25746 |
T25745 |
punct |
-,terminal |
R7587 |
T25747 |
T25743 |
compound |
amino,acids |
R7588 |
T25748 |
T25749 |
dep |
that,encode |
R7589 |
T25749 |
T25743 |
relcl |
encode,acids |
R7590 |
T25750 |
T25751 |
det |
the,domains |
R7591 |
T25751 |
T25749 |
dobj |
domains,encode |
R7592 |
T25752 |
T25751 |
nmod |
NLS,domains |
R7593 |
T25753 |
T25752 |
punct |
", ",NLS |
R7594 |
T25754 |
T25752 |
conj |
DNA,NLS |
R7595 |
T25755 |
T25754 |
punct |
-,DNA |
R7596 |
T25756 |
T25754 |
amod |
binding,DNA |
R7597 |
T25757 |
T25754 |
punct |
", ",DNA |
R7598 |
T25758 |
T25759 |
amod |
marked,box |
R7599 |
T25759 |
T25754 |
conj |
box,DNA |
R7600 |
T25760 |
T25759 |
punct |
", ",box |
R7601 |
T25761 |
T25759 |
conj |
transactivation,box |
R7602 |
T25762 |
T25761 |
punct |
", ",transactivation |
R7603 |
T25763 |
T25761 |
cc |
and,transactivation |
R7604 |
T25764 |
T25761 |
conj |
Rb,transactivation |
R7605 |
T25765 |
T25764 |
punct |
-,Rb |
R7606 |
T25766 |
T25764 |
amod |
binding,Rb |
R7607 |
T25767 |
T25768 |
punct |
[,16 |
R7608 |
T25768 |
T25739 |
parataxis |
16,share |
R7609 |
T25769 |
T25768 |
punct |
],16 |
R7610 |
T25770 |
T25739 |
punct |
", ",share |
R7611 |
T25771 |
T25739 |
cc |
yet,share |
R7612 |
T25772 |
T25773 |
nsubj |
they,exhibit |
R7613 |
T25773 |
T25739 |
conj |
exhibit,share |
R7614 |
T25774 |
T25775 |
amod |
different,distribution |
R7615 |
T25775 |
T25773 |
dobj |
distribution,exhibit |
R7616 |
T25776 |
T25775 |
amod |
subcellular,distribution |
R7617 |
T25777 |
T25773 |
prep |
in,exhibit |
R7618 |
T25778 |
T25779 |
amod |
developing,cells |
R7619 |
T25779 |
T25777 |
pobj |
cells,in |
R7620 |
T25780 |
T25779 |
amod |
retinal,cells |
R7621 |
T25781 |
T25773 |
punct |
.,exhibit |
R7622 |
T25783 |
T25784 |
nsubj |
E2f3a,is |
R7623 |
T25785 |
T25786 |
preconj |
both,nuclear |
R7624 |
T25786 |
T25784 |
acomp |
nuclear,is |
R7625 |
T25787 |
T25786 |
cc |
and,nuclear |
R7626 |
T25788 |
T25786 |
conj |
cytoplasmic,nuclear |
R7627 |
T25789 |
T25784 |
punct |
", ",is |
R7628 |
T25790 |
T25784 |
cc |
but,is |
R7629 |
T25791 |
T25792 |
nsubj |
E2f3b,is |
R7630 |
T25792 |
T25784 |
conj |
is,is |
R7631 |
T25793 |
T25792 |
advmod |
always,is |
R7632 |
T25794 |
T25792 |
acomp |
nuclear,is |
R7633 |
T25795 |
T25792 |
punct |
.,is |
R7634 |
T25797 |
T25798 |
det |
The,termini |
R7635 |
T25798 |
T25808 |
nsubj |
termini,mediate |
R7636 |
T25799 |
T25798 |
amod |
unique,termini |
R7637 |
T25800 |
T25801 |
nummod |
121,residue |
R7638 |
T25801 |
T25798 |
compound |
residue,termini |
R7639 |
T25802 |
T25800 |
punct |
-,121 |
R7640 |
T25803 |
T25800 |
cc |
and,121 |
R7641 |
T25804 |
T25800 |
conj |
six,121 |
R7642 |
T25805 |
T25801 |
punct |
-,residue |
R7643 |
T25806 |
T25798 |
compound |
N,termini |
R7644 |
T25807 |
T25798 |
punct |
-,termini |
R7645 |
T25809 |
T25798 |
prep |
of,termini |
R7646 |
T25810 |
T25809 |
pobj |
E2f3a,of |
R7647 |
T25811 |
T25810 |
cc |
and,E2f3a |
R7648 |
T25812 |
T25810 |
conj |
E2f3b,E2f3a |
R7649 |
T25813 |
T25808 |
punct |
", ",mediate |
R7650 |
T25814 |
T25808 |
advmod |
respectively,mediate |
R7651 |
T25815 |
T25808 |
punct |
", ",mediate |
R7652 |
T25816 |
T25808 |
advmod |
likely,mediate |
R7653 |
T25817 |
T25818 |
det |
this,difference |
R7654 |
T25818 |
T25808 |
dobj |
difference,mediate |
R7655 |
T25819 |
T25808 |
punct |
.,mediate |
R7656 |
T25821 |
T25822 |
det |
This,region |
R7657 |
T25822 |
T25823 |
nsubj |
region,binds |
R7658 |
T25824 |
T25822 |
prep |
in,region |
R7659 |
T25825 |
T25824 |
pobj |
E2f1,in |
R7660 |
T25826 |
T25825 |
punct |
", ",E2f1 |
R7661 |
T25827 |
T25825 |
conj |
E2f2,E2f1 |
R7662 |
T25828 |
T25827 |
punct |
", ",E2f2 |
R7663 |
T25829 |
T25827 |
cc |
and,E2f2 |
R7664 |
T25830 |
T25827 |
conj |
E2f3a,E2f2 |
R7665 |
T25831 |
T25823 |
dobj |
Ccna2,binds |
R7666 |
T25832 |
T25823 |
punct |
", ",binds |
R7667 |
T25833 |
T25823 |
advcl |
establishing,binds |
R7668 |
T25834 |
T25835 |
det |
a,loop |
R7669 |
T25835 |
T25833 |
dobj |
loop,establishing |
R7670 |
T25836 |
T25835 |
amod |
negative,loop |
R7671 |
T25837 |
T25835 |
amod |
regulatory,loop |
R7672 |
T25838 |
T25839 |
dep |
that,deactivates |
R7673 |
T25839 |
T25835 |
relcl |
deactivates,loop |
R7674 |
T25840 |
T25839 |
dobj |
E2fs,deactivates |
R7675 |
T25841 |
T25839 |
prep |
in,deactivates |
R7676 |
T25842 |
T25843 |
amod |
mid,late |
R7677 |
T25843 |
T25845 |
amod |
late,phase |
R7678 |
T25844 |
T25843 |
punct |
-,late |
R7679 |
T25845 |
T25841 |
pobj |
phase,in |
R7680 |
T25846 |
T25845 |
compound |
S,phase |
R7681 |
T25847 |
T25845 |
punct |
-,phase |
R7682 |
T25848 |
T25849 |
punct |
[,65 |
R7683 |
T25849 |
T25833 |
parataxis |
65,establishing |
R7684 |
T25850 |
T25849 |
nummod |
64,65 |
R7685 |
T25851 |
T25849 |
punct |
",",65 |
R7686 |
T25852 |
T25849 |
punct |
],65 |
R7687 |
T25853 |
T25823 |
punct |
.,binds |
R7688 |
T25855 |
T25856 |
advmod |
However,binds |
R7689 |
T25857 |
T25856 |
punct |
", ",binds |
R7690 |
T25858 |
T25859 |
advmod |
even,E2f3b |
R7691 |
T25859 |
T25856 |
nsubj |
E2f3b,binds |
R7692 |
T25860 |
T25859 |
punct |
", ",E2f3b |
R7693 |
T25861 |
T25862 |
dep |
which,lacks |
R7694 |
T25862 |
T25859 |
relcl |
lacks,E2f3b |
R7695 |
T25863 |
T25864 |
det |
this,domain |
R7696 |
T25864 |
T25862 |
dobj |
domain,lacks |
R7697 |
T25865 |
T25856 |
punct |
", ",binds |
R7698 |
T25866 |
T25856 |
cc |
and,binds |
R7699 |
T25867 |
T25868 |
auxpass |
is,regulated |
R7700 |
T25868 |
T25856 |
conj |
regulated,binds |
R7701 |
T25869 |
T25868 |
agent |
by,regulated |
R7702 |
T25870 |
T25868 |
dobj |
Ccna2,regulated |
R7703 |
T25871 |
T25872 |
punct |
[,18 |
R7704 |
T25872 |
T25870 |
parataxis |
18,Ccna2 |
R7705 |
T25873 |
T25872 |
punct |
],18 |
R7706 |
T25874 |
T25856 |
punct |
", ",binds |
R7707 |
T25875 |
T25876 |
mark |
so,explain |
R7708 |
T25876 |
T25856 |
advcl |
explain,binds |
R7709 |
T25877 |
T25878 |
det |
the,difference |
R7710 |
T25878 |
T25876 |
nsubj |
difference,explain |
R7711 |
T25879 |
T25878 |
compound |
domain,difference |
R7712 |
T25880 |
T25876 |
aux |
may,explain |
R7713 |
T25881 |
T25876 |
neg |
not,explain |
R7714 |
T25882 |
T25883 |
det |
the,distributions |
R7715 |
T25883 |
T25876 |
dobj |
distributions,explain |
R7716 |
T25884 |
T25883 |
amod |
unique,distributions |
R7717 |
T25885 |
T25886 |
nsubj |
we,observed |
R7718 |
T25886 |
T25883 |
advcl |
observed,distributions |
R7719 |
T25887 |
T25856 |
punct |
.,binds |
R7720 |
T25889 |
T25890 |
nmod |
Rb,family |
R7721 |
T25890 |
T25891 |
nmod |
family,proteins |
R7722 |
T25891 |
T25894 |
nsubj |
proteins,determine |
R7723 |
T25892 |
T25890 |
cc |
and,family |
R7724 |
T25893 |
T25890 |
conj |
Tfdp,family |
R7725 |
T25895 |
T25894 |
aux |
can,determine |
R7726 |
T25896 |
T25894 |
advmod |
also,determine |
R7727 |
T25897 |
T25898 |
compound |
E2f,localization |
R7728 |
T25898 |
T25894 |
dobj |
localization,determine |
R7729 |
T25899 |
T25900 |
punct |
[,20 |
R7730 |
T25900 |
T25894 |
parataxis |
20,determine |
R7731 |
T25901 |
T25902 |
punct |
–,22 |
R7732 |
T25902 |
T25900 |
prep |
22,20 |
R7733 |
T25903 |
T25900 |
punct |
],20 |
R7734 |
T25904 |
T25894 |
punct |
", ",determine |
R7735 |
T25905 |
T25894 |
cc |
and,determine |
R7736 |
T25906 |
T25907 |
nsubj |
we,found |
R7737 |
T25907 |
T25894 |
conj |
found,determine |
R7738 |
T25908 |
T25909 |
mark |
that,are |
R7739 |
T25909 |
T25907 |
ccomp |
are,found |
R7740 |
T25910 |
T25911 |
det |
a,portion |
R7741 |
T25911 |
T25909 |
nsubj |
portion,are |
R7742 |
T25912 |
T25911 |
prep |
of,portion |
R7743 |
T25913 |
T25914 |
preconj |
both,Rb |
R7744 |
T25914 |
T25915 |
nmod |
Rb,proteins |
R7745 |
T25915 |
T25912 |
pobj |
proteins,of |
R7746 |
T25916 |
T25914 |
cc |
and,Rb |
R7747 |
T25917 |
T25914 |
conj |
Tfdp1,Rb |
R7748 |
T25918 |
T25909 |
acomp |
cytoplasmic,are |
R7749 |
T25919 |
T25909 |
prep |
in,are |
R7750 |
T25920 |
T25921 |
amod |
retinal,cells |
R7751 |
T25921 |
T25919 |
pobj |
cells,in |
R7752 |
T25922 |
T25907 |
punct |
.,found |
R7753 |
T25924 |
T25925 |
advmod |
Indeed,revealed |
R7754 |
T25926 |
T25925 |
punct |
", ",revealed |
R7755 |
T25927 |
T25925 |
nsubj |
immunostaining,revealed |
R7756 |
T25928 |
T25929 |
mark |
that,colocalize |
R7757 |
T25929 |
T25925 |
ccomp |
colocalize,revealed |
R7758 |
T25930 |
T25929 |
nsubj |
Rb,colocalize |
R7759 |
T25931 |
T25930 |
cc |
and,Rb |
R7760 |
T25932 |
T25930 |
conj |
E2f3,Rb |
R7761 |
T25933 |
T25929 |
prep |
to,colocalize |
R7762 |
T25934 |
T25935 |
compound |
SAC,processes |
R7763 |
T25935 |
T25933 |
pobj |
processes,to |
R7764 |
T25936 |
T25925 |
punct |
.,revealed |
R7765 |
T25938 |
T25939 |
det |
The,localization |
R7766 |
T25939 |
T25941 |
nsubj |
localization,contrasts |
R7767 |
T25940 |
T25939 |
amod |
nuclear,localization |
R7768 |
T25942 |
T25939 |
prep |
of,localization |
R7769 |
T25943 |
T25942 |
pobj |
E2f3b,of |
R7770 |
T25944 |
T25941 |
prep |
with,contrasts |
R7771 |
T25945 |
T25944 |
pobj |
that,with |
R7772 |
T25946 |
T25945 |
prep |
of,that |
R7773 |
T25947 |
T25948 |
amod |
other,E2fs |
R7774 |
T25948 |
T25946 |
pobj |
E2fs,of |
R7775 |
T25949 |
T25948 |
amod |
repressive,E2fs |
R7776 |
T25950 |
T25948 |
prep |
in,E2fs |
R7777 |
T25951 |
T25952 |
amod |
differentiating,muscle |
R7778 |
T25952 |
T25950 |
pobj |
muscle,in |
R7779 |
T25953 |
T25952 |
punct |
", ",muscle |
R7780 |
T25954 |
T25955 |
advmod |
where,switches |
R7781 |
T25955 |
T25952 |
relcl |
switches,muscle |
R7782 |
T25956 |
T25955 |
nsubj |
E2f5,switches |
R7783 |
T25957 |
T25955 |
prep |
from,switches |
R7784 |
T25958 |
T25959 |
det |
the,nucleus |
R7785 |
T25959 |
T25957 |
pobj |
nucleus,from |
R7786 |
T25960 |
T25957 |
prep |
to,from |
R7787 |
T25961 |
T25960 |
pobj |
cytoplasm,to |
R7788 |
T25962 |
T25941 |
punct |
", ",contrasts |
R7789 |
T25963 |
T25964 |
mark |
while,remains |
R7790 |
T25964 |
T25941 |
advcl |
remains,contrasts |
R7791 |
T25965 |
T25964 |
nsubj |
E2f4,remains |
R7792 |
T25966 |
T25964 |
prep |
in,remains |
R7793 |
T25967 |
T25968 |
det |
both,compartments |
R7794 |
T25968 |
T25966 |
pobj |
compartments,in |
R7795 |
T25969 |
T25970 |
punct |
[,23 |
R7796 |
T25970 |
T25964 |
parataxis |
23,remains |
R7797 |
T25971 |
T25970 |
punct |
],23 |
R7798 |
T25972 |
T25941 |
punct |
.,contrasts |
R7799 |
T25974 |
T25975 |
det |
The,compartmentalization |
R7800 |
T25975 |
T25977 |
nsubj |
compartmentalization,suggests |
R7801 |
T25976 |
T25975 |
amod |
distinct,compartmentalization |
R7802 |
T25978 |
T25975 |
prep |
of,compartmentalization |
R7803 |
T25979 |
T25978 |
pobj |
E2f3a,of |
R7804 |
T25980 |
T25979 |
cc |
and,E2f3a |
R7805 |
T25981 |
T25979 |
conj |
E2f3b,E2f3a |
R7806 |
T25982 |
T25975 |
prep |
in,compartmentalization |
R7807 |
T25983 |
T25984 |
det |
the,retina |
R7808 |
T25984 |
T25982 |
pobj |
retina,in |
R7809 |
T25985 |
T25986 |
advmod |
temporally,distinct |
R7810 |
T25986 |
T25989 |
amod |
distinct,activities |
R7811 |
T25987 |
T25985 |
cc |
and,temporally |
R7812 |
T25988 |
T25985 |
conj |
functionally,temporally |
R7813 |
T25989 |
T25977 |
dobj |
activities,suggests |
R7814 |
T25990 |
T25977 |
punct |
.,suggests |
R7815 |
T25992 |
T25993 |
compound |
Rb,distribution |
R7816 |
T25993 |
T25994 |
nsubj |
distribution,matches |
R7817 |
T25995 |
T25994 |
dobj |
that,matches |
R7818 |
T25996 |
T25995 |
prep |
of,that |
R7819 |
T25997 |
T25996 |
pobj |
E2f3a,of |
R7820 |
T25998 |
T25994 |
punct |
", ",matches |
R7821 |
T25999 |
T25994 |
advcl |
consistent,matches |
R7822 |
T26000 |
T25999 |
prep |
with,consistent |
R7823 |
T26001 |
T26002 |
poss |
its,role |
R7824 |
T26002 |
T26000 |
pobj |
role,with |
R7825 |
T26003 |
T26002 |
amod |
critical,role |
R7826 |
T26004 |
T26002 |
prep |
in,role |
R7827 |
T26005 |
T26004 |
pcomp |
supporting,in |
R7828 |
T26006 |
T26007 |
compound |
SAC,differentiation |
R7829 |
T26007 |
T26005 |
dobj |
differentiation,supporting |
R7830 |
T26008 |
T26005 |
prep |
through,supporting |
R7831 |
T26009 |
T26008 |
pobj |
E2f3a,through |
R7832 |
T26010 |
T25994 |
punct |
.,matches |