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PMC:1914394 / 47679-48473 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T24826 69-72 PRP$ denotes its
T24827 73-77 NN denotes role
T24828 78-80 IN denotes in
T24829 81-92 VBG denotes controlling
T24830 93-101 NN denotes division
T24831 102-104 CC denotes or
T24832 105-110 NN denotes death
T24833 110-112 : denotes :
T24834 112-116 NN denotes E2f3
T24835 117-125 NN denotes deletion
T24836 134-136 NN denotes Rb
T24837 137-139 NN denotes KO
T24838 144-151 NNS denotes defects
T24839 140-143 NN denotes SAC
T24840 152-155 CC denotes but
T24841 156-159 VBD denotes did
T24842 164-172 VB denotes suppress
T24843 160-163 RB denotes not
T24844 173-181 JJ denotes aberrant
T24845 182-195 NN denotes proliferation
T24846 196-198 CC denotes or
T24847 199-204 NN denotes death
T24848 204-206 , denotes ,
T24849 206-213 IN denotes whereas
T24850 228-236 VBD denotes reversed
T24851 214-218 NN denotes E2f1
T24852 219-227 NN denotes deletion
T24853 237-245 JJ denotes abnormal
T24854 246-259 NN denotes proliferation
T24855 260-263 CC denotes and
T24856 264-269 NN denotes death
T24857 270-273 CC denotes but
T24858 274-277 VBD denotes did
T24859 282-288 VB denotes rescue
T24860 278-281 RB denotes not
T24861 289-292 NN denotes SAC
T24862 293-308 NN denotes differentiation
T24863 308-309 . denotes .
T24864 309-397 sentence denotes Double labelling confirmed that E2f1 but not E2f3 deletion reversed Rb KO SAC division.
T24865 310-316 JJ denotes Double
T24866 317-326 NN denotes labelling
T24867 327-336 VBD denotes confirmed
T24868 337-341 IN denotes that
T24869 369-377 VBD denotes reversed
T24870 342-346 NN denotes E2f1
T24871 360-368 NN denotes deletion
T24872 347-350 CC denotes but
T24873 351-354 RB denotes not
T24874 355-359 NN denotes E2f3
T24875 378-380 NN denotes Rb
T24876 381-383 NN denotes KO
T24877 384-387 NN denotes SAC
T24878 388-396 NN denotes division
T24879 396-397 . denotes .
T24880 397-523 sentence denotes Moreover, deleting E2f1, but not E2f3, reversed deregulated expression of cell cycle and apoptotic genes in the Rb KO retina.
T24881 398-406 RB denotes Moreover
T24882 437-445 VBD denotes reversed
T24883 406-408 , denotes ,
T24884 408-416 VBG denotes deleting
T24885 417-421 NN denotes E2f1
T24886 421-423 , denotes ,
T24887 423-426 CC denotes but
T24888 427-430 RB denotes not
T24889 431-435 NN denotes E2f3
T24890 435-437 , denotes ,
T24891 446-457 VBN denotes deregulated
T24892 458-468 NN denotes expression
T24893 469-471 IN denotes of
T24894 472-476 NN denotes cell
T24895 477-482 NN denotes cycle
T24896 483-486 CC denotes and
T24897 487-496 JJ denotes apoptotic
T24898 497-502 NNS denotes genes
T24899 503-505 IN denotes in
T24900 506-509 DT denotes the
T24901 516-522 NN denotes retina
T24902 510-512 NN denotes Rb
T24903 513-515 NN denotes KO
T24904 522-523 . denotes .
T24905 523-664 sentence denotes E2f3 is expressed in a subset of CNS neurons (this work) and drives specific cell-cycle–independent defects in Rb KO forebrain neurons [53].
T24906 524-528 NN denotes E2f3
T24907 532-541 VBN denotes expressed
T24908 529-531 VBZ denotes is
T24909 542-544 IN denotes in
T24910 545-546 DT denotes a
T24911 547-553 NN denotes subset
T24912 554-556 IN denotes of
T24913 557-560 NN denotes CNS
T24914 561-568 NNS denotes neurons
T24915 569-570 -LRB- denotes (
T24916 575-579 NN denotes work
T24917 570-574 DT denotes this
T24918 579-580 -RRB- denotes )
T24919 581-584 CC denotes and
T24920 585-591 VBZ denotes drives
T24921 592-600 JJ denotes specific
T24922 624-631 NNS denotes defects
T24923 601-605 NN denotes cell
T24924 606-611 NN denotes cycle
T24925 605-606 HYPH denotes -
T24926 612-623 JJ denotes independent
T24927 611-612 HYPH denotes –
T24928 632-634 IN denotes in
T24929 635-637 NN denotes Rb
T24930 638-640 NN denotes KO
T24931 651-658 NNS denotes neurons
T24932 641-650 NN denotes forebrain
T24933 659-660 -LRB- denotes [
T24934 660-662 CD denotes 53
T24935 662-663 -RRB- denotes ]
T24936 663-664 . denotes .
T24937 664-794 sentence denotes Thus, E2f3 inhibition is the first, and may be the only, mechanism by which Rb participates directly in neuronal differentiation.
T24938 665-669 RB denotes Thus
T24939 687-689 VBZ denotes is
T24940 669-671 , denotes ,
T24941 671-675 NN denotes E2f3
T24942 676-686 NN denotes inhibition
T24943 690-693 DT denotes the
T24944 694-699 JJ denotes first
T24945 699-701 , denotes ,
T24946 701-704 CC denotes and
T24947 705-708 MD denotes may
T24948 709-711 VB denotes be
T24949 712-715 DT denotes the
T24950 716-720 JJ denotes only
T24951 720-722 , denotes ,
T24952 722-731 NN denotes mechanism
T24953 732-734 IN denotes by
T24954 744-756 VBZ denotes participates
T24955 735-740 WDT denotes which
T24956 741-743 NN denotes Rb
T24957 757-765 RB denotes directly
T24958 766-768 IN denotes in
T24959 769-777 JJ denotes neuronal
T24960 778-793 NN denotes differentiation
T24961 793-794 . denotes .
T24814 39-40 EX denotes r
T24815 40-41 DT denotes o
T24816 41-42 VBN denotes u
T24817 42-43 sentence denotes g
T24818 42-43 NN denotes g
T24821 43-44 IN denotes h
T24822 45-49 NN denotes E2f3
T24823 126-133 VBD denotes rescued
T24824 54-65 JJ denotes independent
T24825 66-68 IN denotes of
T24805 11-13 VBG denotes on
T24806 14-15 RB denotes o
T24807 15-16 IN denotes f
T24808 17-39 sentence denotes SAC differentiation th
T24809 17-20 NN denotes SAC
T24810 21-36 NN denotes differentiation
T24811 36-37 , denotes
T24812 37-39 DT denotes th
T24813 39-42 sentence denotes rou
T24819 43-309 sentence denotes h E2f3 was independent of its role in controlling division or death: E2f3 deletion rescued Rb KO SAC defects but did not suppress aberrant proliferation or death, whereas E2f1 deletion reversed abnormal proliferation and death but did not rescue SAC differentiation.
T24820 50-53 VBD denotes was
R7307 T24822 T24821 pobj E2f3,h
R7308 T24824 T24820 acomp independent,was
R7309 T24825 T24824 prep of,independent
R7310 T24826 T24827 poss its,role
R7311 T24827 T24825 pobj role,of
R7312 T24828 T24827 prep in,role
R7313 T24829 T24828 pcomp controlling,in
R7314 T24830 T24829 dobj division,controlling
R7315 T24831 T24830 cc or,division
R7316 T24832 T24830 conj death,division
R7317 T24833 T24823 punct : ,rescued
R7318 T24834 T24835 compound E2f3,deletion
R7319 T24835 T24823 nsubj deletion,rescued
R7320 T24836 T24837 compound Rb,KO
R7321 T24837 T24838 compound KO,defects
R7322 T24838 T24823 dobj defects,rescued
R7323 T24839 T24838 compound SAC,defects
R7324 T24840 T24823 cc but,rescued
R7325 T24841 T24842 aux did,suppress
R7326 T24842 T24823 conj suppress,rescued
R7327 T24843 T24842 neg not,suppress
R7328 T24844 T24845 amod aberrant,proliferation
R7329 T24845 T24842 dobj proliferation,suppress
R7330 T24846 T24845 cc or,proliferation
R7331 T24847 T24845 conj death,proliferation
R7332 T24848 T24842 punct ", ",suppress
R7333 T24849 T24850 mark whereas,reversed
R7334 T24850 T24842 advcl reversed,suppress
R7335 T24851 T24852 compound E2f1,deletion
R7336 T24852 T24850 nsubj deletion,reversed
R7337 T24853 T24854 amod abnormal,proliferation
R7338 T24854 T24850 dobj proliferation,reversed
R7339 T24855 T24854 cc and,proliferation
R7340 T24856 T24854 conj death,proliferation
R7341 T24857 T24850 cc but,reversed
R7342 T24858 T24859 aux did,rescue
R7343 T24859 T24850 conj rescue,reversed
R7344 T24860 T24859 neg not,rescue
R7345 T24861 T24862 compound SAC,differentiation
R7346 T24862 T24859 dobj differentiation,rescue
R7347 T24863 T24823 punct .,rescued
R7348 T24865 T24866 amod Double,labelling
R7349 T24866 T24867 nsubj labelling,confirmed
R7350 T24868 T24869 mark that,reversed
R7351 T24869 T24867 ccomp reversed,confirmed
R7352 T24870 T24871 nmod E2f1,deletion
R7353 T24871 T24869 nsubj deletion,reversed
R7354 T24872 T24870 cc but,E2f1
R7355 T24873 T24872 neg not,but
R7356 T24874 T24870 conj E2f3,E2f1
R7357 T24875 T24876 compound Rb,KO
R7358 T24876 T24877 compound KO,SAC
R7359 T24877 T24878 compound SAC,division
R7360 T24878 T24869 dobj division,reversed
R7361 T24879 T24867 punct .,confirmed
R7362 T24881 T24882 advmod Moreover,reversed
R7363 T24883 T24882 punct ", ",reversed
R7364 T24884 T24882 csubj deleting,reversed
R7365 T24885 T24884 dobj E2f1,deleting
R7366 T24886 T24885 punct ", ",E2f1
R7367 T24887 T24885 cc but,E2f1
R7368 T24888 T24887 neg not,but
R7369 T24889 T24885 conj E2f3,E2f1
R7370 T24890 T24882 punct ", ",reversed
R7371 T24891 T24892 amod deregulated,expression
R7372 T24892 T24882 dobj expression,reversed
R7373 T24893 T24892 prep of,expression
R7374 T24894 T24895 compound cell,cycle
R7375 T24895 T24893 pobj cycle,of
R7376 T24896 T24895 cc and,cycle
R7377 T24897 T24898 amod apoptotic,genes
R7378 T24898 T24895 conj genes,cycle
R7379 T24899 T24882 prep in,reversed
R7380 T24900 T24901 det the,retina
R7381 T24901 T24899 pobj retina,in
R7382 T24902 T24903 compound Rb,KO
R7383 T24903 T24901 compound KO,retina
R7384 T24904 T24882 punct .,reversed
R7385 T24906 T24907 nsubjpass E2f3,expressed
R7386 T24908 T24907 auxpass is,expressed
R7387 T24909 T24907 prep in,expressed
R7388 T24910 T24911 det a,subset
R7389 T24911 T24909 pobj subset,in
R7400 T24922 T24920 dobj defects,drives
R7402 T24924 T24926 npadvmod cycle,independent
R7403 T24925 T24924 punct -,cycle
R7404 T24926 T24922 amod independent,defects
R7405 T24927 T24926 punct –,independent
R7406 T24928 T24920 prep in,drives
R7407 T24929 T24930 compound Rb,KO
R7408 T24930 T24931 compound KO,neurons
R7409 T24931 T24928 pobj neurons,in
R7410 T24932 T24931 compound forebrain,neurons
R7411 T24933 T24934 punct [,53
R7412 T24934 T24920 parataxis 53,drives
R7413 T24935 T24934 punct ],53
R7414 T24936 T24907 punct .,expressed
R7415 T24938 T24939 advmod Thus,is
R7416 T24940 T24939 punct ", ",is
R7417 T24941 T24942 compound E2f3,inhibition
R7418 T24942 T24939 nsubj inhibition,is
R7419 T24943 T24944 det the,first
R7420 T24944 T24939 attr first,is
R7421 T24945 T24939 punct ", ",is
R7422 T24946 T24939 cc and,is
R7423 T24947 T24948 aux may,be
R7424 T24948 T24939 conj be,is
R7425 T24949 T24950 det the,only
R7426 T24950 T24948 attr only,be
R7427 T24951 T24948 punct ", ",be
R7428 T24952 T24948 conj mechanism,be
R7429 T24953 T24954 prep by,participates
R7430 T24954 T24952 ccomp participates,mechanism
R7431 T24955 T24953 pobj which,by
R7432 T24956 T24954 nsubj Rb,participates
R7433 T24957 T24954 advmod directly,participates
R7434 T24958 T24954 prep in,participates
R7435 T24959 T24960 amod neuronal,differentiation
R7436 T24960 T24958 pobj differentiation,in
R7437 T24961 T24939 punct .,is
R7303 T24806 T24807 advmod o,f
R7304 T24807 T24805 oprd f,on
R7305 T24809 T24810 compound SAC,differentiation
R7306 T24820 T24823 ccomp was,rescued
R7390 T24912 T24911 prep of,subset
R7391 T24913 T24914 compound CNS,neurons
R7392 T24914 T24912 pobj neurons,of
R7393 T24915 T24916 punct (,work
R7394 T24916 T24907 parataxis work,expressed
R7395 T24917 T24916 det this,work
R7396 T24918 T24916 punct ),work
R7397 T24919 T24907 cc and,expressed
R7398 T24920 T24907 conj drives,expressed
R7399 T24921 T24922 amod specific,defects
R7401 T24923 T24924 compound cell,cycle

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T24540 21-36 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24541 45-49 PR_EXT:000006854 denotes E2f3
T24542 81-92 GO:0065007 denotes controlling
T24543 105-110 GO:0016265 denotes death
T24544 112-116 PR_EXT:000006854 denotes E2f3
T24545 117-125 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T24546 126-133 SO_EXT:sequence_rescue_process denotes rescued
T24547 134-136 PR_EXT:000013773 denotes Rb
T24548 182-195 GO:0008283 denotes proliferation
T24549 199-204 GO:0016265 denotes death
T24550 214-218 PR_EXT:000006852 denotes E2f1
T24551 219-227 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T24552 246-259 GO:0008283 denotes proliferation
T24553 264-269 GO:0016265 denotes death
T24554 282-288 SO_EXT:sequence_rescue_process denotes rescue
T24555 293-308 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24556 317-326 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labelling
T24557 342-346 PR_EXT:000006852 denotes E2f1
T24558 355-359 PR_EXT:000006854 denotes E2f3
T24559 360-368 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T24560 378-380 PR_EXT:000013773 denotes Rb
T24561 408-416 SO_EXT:sequence_deletion_process denotes deleting
T24562 417-421 PR_EXT:000006852 denotes E2f1
T24563 431-435 PR_EXT:000006854 denotes E2f3
T24564 448-457 GO:0065007 denotes regulated
T24565 458-468 GO:0010467 denotes expression
T24566 472-476 CL_GO_EXT:cell denotes cell
T24567 472-482 GO:0007049 denotes cell cycle
T24568 487-496 GO_PATO_EXT:apoptotic_process_or_quality denotes apoptotic
T24569 497-502 SO_EXT:0000704 denotes genes
T24570 510-512 PR_EXT:000013773 denotes Rb
T24571 516-522 UBERON:0000966 denotes retina
T24572 524-528 PR_EXT:000006854 denotes E2f3
T24573 532-541 GO:0010467 denotes expressed
T24574 557-560 UBERON:0001017 denotes CNS
T24575 557-568 CL:0000117 denotes CNS neurons
T24576 601-605 CL_GO_EXT:cell denotes cell
T24577 601-611 GO:0007049 denotes cell-cycle
T24578 635-637 PR_EXT:000013773 denotes Rb
T24579 641-650 UBERON:0001890 denotes forebrain
T24580 641-658 CL:0012001 denotes forebrain neurons
T24581 671-675 PR_EXT:000006854 denotes E2f3
T24582 741-743 PR_EXT:000013773 denotes Rb
T24583 769-777 CL:0000540 denotes neuronal
T24584 778-793 GO_RO_EXT:developmental_differentiation_process denotes differentiation

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T24468 431-435 PR:000006854 denotes E2f3
T24469 448-457 GO:0065007 denotes regulated
T24470 458-468 GO:0010467 denotes expression
T24471 472-482 GO:0007049 denotes cell cycle
T24472 497-502 SO:0000704 denotes genes
T24473 510-512 PR:000013773 denotes Rb
T24474 516-522 UBERON:0000966 denotes retina
T24475 524-528 PR:000006854 denotes E2f3
T24454 45-49 PR:000006854 denotes E2f3
T24455 81-92 GO:0065007 denotes controlling
T24456 105-110 GO:0016265 denotes death
T24457 112-116 PR:000006854 denotes E2f3
T24458 134-136 PR:000013773 denotes Rb
T24459 182-195 GO:0008283 denotes proliferation
T24460 199-204 GO:0016265 denotes death
T24461 214-218 PR:000006852 denotes E2f1
T24462 246-259 GO:0008283 denotes proliferation
T24463 264-269 GO:0016265 denotes death
T24464 342-346 PR:000006852 denotes E2f1
T24465 355-359 PR:000006854 denotes E2f3
T24466 378-380 PR:000013773 denotes Rb
T24467 417-421 PR:000006852 denotes E2f1
T24476 532-541 GO:0010467 denotes expressed
T24477 557-560 UBERON:0001017 denotes CNS
T24478 557-568 CL:0000117 denotes CNS neurons
T24479 601-611 GO:0007049 denotes cell-cycle
T24480 635-637 PR:000013773 denotes Rb
T24481 641-650 UBERON:0001890 denotes forebrain
T24482 641-658 CL:0012001 denotes forebrain neurons
T24483 671-675 PR:000006854 denotes E2f3
T24484 741-743 PR:000013773 denotes Rb
T24485 769-777 CL:0000540 denotes neuronal