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PMC:1914394 / 44642-45494 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T23294 0-2 PRP denotes We
T23295 13-18 VBN denotes found
T23296 3-7 VBP denotes have
T23297 8-12 RB denotes also
T23298 19-23 IN denotes that
T23299 38-45 VBZ denotes rescues
T23300 24-28 NN denotes E2f1
T23301 29-37 NN denotes deletion
T23302 46-50 NN denotes cell
T23303 51-61 JJ denotes autonomous
T23304 50-51 HYPH denotes -
T23305 70-78 NN denotes division
T23306 62-69 JJ denotes ectopic
T23307 78-80 , denotes ,
T23308 80-85 NN denotes death
T23309 85-87 , denotes ,
T23310 87-90 CC denotes and
T23311 91-106 NN denotes differentiation
T23312 107-114 NNS denotes defects
T23313 115-117 IN denotes in
T23314 118-126 JJ denotes sporadic
T23315 133-139 NNS denotes clones
T23316 127-129 NN denotes Rb
T23317 130-132 NN denotes KO
T23318 140-149 VBN denotes generated
T23319 150-155 VBG denotes using
T23320 156-157 DT denotes a
T23321 173-179 NN denotes vector
T23322 158-161 NN denotes Cre
T23323 162-172 NN denotes retrovirus
T23324 180-181 -LRB- denotes (
T23325 181-183 NNP denotes M.
T23326 184-186 NNP denotes P.
T23327 187-190 CC denotes and
T23328 191-193 NNP denotes R.
T23329 194-196 NNP denotes B.
T23330 196-198 , denotes ,
T23331 198-209 JJ denotes unpublished
T23332 210-214 NNS denotes data
T23333 214-215 -RRB- denotes )
T23334 215-216 . denotes .
T23335 216-532 sentence denotes These data are consistent with the observation that E2f1 overexpression in newborn photoreceptors drives ectopic division and apoptosis [60], and add to the growing evidence indicating that E2f1 is the major, and perhaps only, member of the three activating E2fs required to induce apoptosis in Rb KO cells [10,15].
T23336 217-222 DT denotes These
T23337 223-227 NNS denotes data
T23338 228-231 VBP denotes are
T23339 232-242 JJ denotes consistent
T23340 243-247 IN denotes with
T23341 248-251 DT denotes the
T23342 252-263 NN denotes observation
T23343 264-268 IN denotes that
T23344 315-321 VBZ denotes drives
T23345 269-273 NN denotes E2f1
T23346 274-288 NN denotes overexpression
T23347 289-291 IN denotes in
T23348 292-299 JJ denotes newborn
T23349 300-314 NNS denotes photoreceptors
T23350 322-329 JJ denotes ectopic
T23351 330-338 NN denotes division
T23352 339-342 CC denotes and
T23353 343-352 NN denotes apoptosis
T23354 353-354 -LRB- denotes [
T23355 354-356 CD denotes 60
T23356 356-357 -RRB- denotes ]
T23357 357-359 , denotes ,
T23358 359-362 CC denotes and
T23359 363-366 VBP denotes add
T23360 367-369 IN denotes to
T23361 370-373 DT denotes the
T23362 382-390 NN denotes evidence
T23363 374-381 VBG denotes growing
T23364 391-401 VBG denotes indicating
T23365 402-406 IN denotes that
T23366 412-414 VBZ denotes is
T23367 407-411 NN denotes E2f1
T23368 415-418 DT denotes the
T23369 444-450 NN denotes member
T23370 419-424 JJ denotes major
T23371 424-426 , denotes ,
T23372 426-429 CC denotes and
T23373 430-437 RB denotes perhaps
T23374 438-442 JJ denotes only
T23375 442-444 , denotes ,
T23376 451-453 IN denotes of
T23377 454-457 DT denotes the
T23378 475-479 NNS denotes E2fs
T23379 458-463 CD denotes three
T23380 464-474 VBG denotes activating
T23381 480-488 VBN denotes required
T23382 489-491 TO denotes to
T23383 492-498 VB denotes induce
T23384 499-508 NN denotes apoptosis
T23385 509-511 IN denotes in
T23386 512-514 NN denotes Rb
T23387 515-517 NN denotes KO
T23388 518-523 NNS denotes cells
T23389 524-525 -LRB- denotes [
T23390 528-530 CD denotes 15
T23391 525-527 CD denotes 10
T23392 527-528 , denotes ,
T23393 530-531 -RRB- denotes ]
T23394 531-532 . denotes .
T23395 532-728 sentence denotes Thus, deregulated E2f1 activity in the retina, whether resulting from the inactivation of Rb or from overexpression, promotes unscheduled cell division and triggers apoptosis in susceptible RTCs.
T23396 533-537 RB denotes Thus
T23397 650-658 VBZ denotes promotes
T23398 537-539 , denotes ,
T23399 539-550 VBN denotes deregulated
T23400 556-564 NN denotes activity
T23401 551-555 NN denotes E2f1
T23402 565-567 IN denotes in
T23403 568-571 DT denotes the
T23404 572-578 NN denotes retina
T23405 578-580 , denotes ,
T23406 580-587 IN denotes whether
T23407 588-597 VBG denotes resulting
T23408 598-602 IN denotes from
T23409 603-606 DT denotes the
T23410 607-619 NN denotes inactivation
T23411 620-622 IN denotes of
T23412 623-625 NN denotes Rb
T23413 626-628 CC denotes or
T23414 629-633 IN denotes from
T23415 634-648 NN denotes overexpression
T23416 648-650 , denotes ,
T23417 659-670 JJ denotes unscheduled
T23418 676-684 NN denotes division
T23419 671-675 NN denotes cell
T23420 685-688 CC denotes and
T23421 689-697 VBZ denotes triggers
T23422 698-707 NN denotes apoptosis
T23423 708-710 IN denotes in
T23424 711-722 JJ denotes susceptible
T23425 723-727 NNS denotes RTCs
T23426 727-728 . denotes .
T23427 728-852 sentence denotes E2f1, rather than other E2fs, may be a potential target for novel therapeutics to prevent retinoblastoma in RB1 +/− humans.
T23428 729-733 NN denotes E2f1
T23429 763-765 VB denotes be
T23430 733-735 , denotes ,
T23431 735-741 RB denotes rather
T23432 742-746 IN denotes than
T23433 747-752 JJ denotes other
T23434 753-757 NNS denotes E2fs
T23435 757-759 , denotes ,
T23436 759-762 MD denotes may
T23437 766-767 DT denotes a
T23438 778-784 NN denotes target
T23439 768-777 JJ denotes potential
T23440 785-788 IN denotes for
T23441 789-794 JJ denotes novel
T23442 795-807 NNS denotes therapeutics
T23443 808-810 TO denotes to
T23444 811-818 VB denotes prevent
T23445 819-833 NN denotes retinoblastoma
T23446 834-836 IN denotes in
T23447 837-840 NN denotes RB1
T23448 845-851 NNS denotes humans
T23449 841-842 SYM denotes +
T23450 842-843 HYPH denotes /
T23451 843-844 SYM denotes −
T23452 851-852 . denotes .
R6885 T23294 T23295 nsubj We,found
R6886 T23296 T23295 aux have,found
R6887 T23297 T23295 advmod also,found
R6888 T23298 T23299 mark that,rescues
R6889 T23299 T23295 ccomp rescues,found
R6890 T23300 T23301 compound E2f1,deletion
R6891 T23301 T23299 nsubj deletion,rescues
R6892 T23302 T23303 npadvmod cell,autonomous
R6893 T23303 T23305 amod autonomous,division
R6894 T23304 T23303 punct -,autonomous
R6895 T23305 T23299 dobj division,rescues
R6896 T23306 T23305 amod ectopic,division
R6897 T23307 T23305 punct ", ",division
R6898 T23308 T23305 conj death,division
R6899 T23309 T23308 punct ", ",death
R6900 T23310 T23308 cc and,death
R6901 T23311 T23312 compound differentiation,defects
R6902 T23312 T23308 conj defects,death
R6903 T23313 T23299 prep in,rescues
R6904 T23314 T23315 amod sporadic,clones
R6905 T23315 T23313 pobj clones,in
R6906 T23316 T23317 compound Rb,KO
R6907 T23317 T23315 compound KO,clones
R6908 T23318 T23315 acl generated,clones
R6909 T23319 T23318 advcl using,generated
R6910 T23320 T23321 det a,vector
R6911 T23321 T23319 dobj vector,using
R6912 T23322 T23323 compound Cre,retrovirus
R6913 T23323 T23321 compound retrovirus,vector
R6914 T23324 T23325 punct (,M.
R6915 T23325 T23319 meta M.,using
R6916 T23326 T23325 nmod P.,M.
R6917 T23327 T23325 cc and,M.
R6918 T23328 T23325 conj R.,M.
R6919 T23329 T23328 nmod B.,R.
R6920 T23330 T23328 punct ", ",R.
R6921 T23331 T23332 amod unpublished,data
R6922 T23332 T23328 conj data,R.
R6923 T23333 T23332 punct ),data
R6924 T23334 T23295 punct .,found
R6925 T23336 T23337 det These,data
R6926 T23337 T23338 nsubj data,are
R6927 T23339 T23338 acomp consistent,are
R6928 T23340 T23339 prep with,consistent
R6929 T23341 T23342 det the,observation
R6930 T23342 T23340 pobj observation,with
R6931 T23343 T23344 mark that,drives
R6932 T23344 T23342 acl drives,observation
R6933 T23345 T23346 compound E2f1,overexpression
R6934 T23346 T23344 nsubj overexpression,drives
R6935 T23347 T23346 prep in,overexpression
R6936 T23348 T23349 amod newborn,photoreceptors
R6937 T23349 T23347 pobj photoreceptors,in
R6938 T23350 T23351 amod ectopic,division
R6939 T23351 T23344 dobj division,drives
R6940 T23352 T23351 cc and,division
R6941 T23353 T23351 conj apoptosis,division
R6942 T23354 T23355 punct [,60
R6943 T23355 T23344 parataxis 60,drives
R6944 T23356 T23355 punct ],60
R6945 T23357 T23338 punct ", ",are
R6946 T23358 T23338 cc and,are
R6947 T23359 T23338 conj add,are
R6948 T23360 T23359 prep to,add
R6949 T23361 T23362 det the,evidence
R6950 T23362 T23360 pobj evidence,to
R6951 T23363 T23362 amod growing,evidence
R6952 T23364 T23362 acl indicating,evidence
R6953 T23365 T23366 mark that,is
R6954 T23366 T23364 ccomp is,indicating
R6955 T23367 T23366 nsubj E2f1,is
R6956 T23368 T23369 det the,member
R6957 T23369 T23366 attr member,is
R6958 T23370 T23369 amod major,member
R6959 T23371 T23370 punct ", ",major
R6960 T23372 T23370 cc and,major
R6961 T23373 T23374 advmod perhaps,only
R6962 T23374 T23370 conj only,major
R6963 T23375 T23369 punct ", ",member
R6964 T23376 T23369 prep of,member
R6965 T23377 T23378 det the,E2fs
R6966 T23378 T23376 pobj E2fs,of
R6967 T23379 T23378 nummod three,E2fs
R6968 T23380 T23378 amod activating,E2fs
R6969 T23381 T23378 acl required,E2fs
R6970 T23382 T23383 aux to,induce
R6971 T23383 T23381 xcomp induce,required
R6972 T23384 T23383 dobj apoptosis,induce
R6973 T23385 T23383 prep in,induce
R6974 T23386 T23387 compound Rb,KO
R6975 T23387 T23388 compound KO,cells
R6976 T23388 T23385 pobj cells,in
R6977 T23389 T23390 punct [,15
R6978 T23390 T23359 parataxis 15,add
R6979 T23391 T23390 nummod 10,15
R6980 T23392 T23390 punct ",",15
R6981 T23393 T23390 punct ],15
R6982 T23394 T23338 punct .,are
R6983 T23396 T23397 advmod Thus,promotes
R6984 T23398 T23397 punct ", ",promotes
R6985 T23399 T23400 amod deregulated,activity
R6986 T23400 T23397 nsubj activity,promotes
R6987 T23401 T23400 compound E2f1,activity
R6988 T23402 T23400 prep in,activity
R6989 T23403 T23404 det the,retina
R6990 T23404 T23402 pobj retina,in
R6991 T23405 T23397 punct ", ",promotes
R6992 T23406 T23407 mark whether,resulting
R6993 T23407 T23397 advcl resulting,promotes
R6994 T23408 T23407 prep from,resulting
R6995 T23409 T23410 det the,inactivation
R6996 T23410 T23408 pobj inactivation,from
R6997 T23411 T23410 prep of,inactivation
R6998 T23412 T23411 pobj Rb,of
R6999 T23413 T23408 cc or,from
R7000 T23414 T23408 conj from,from
R7001 T23415 T23414 pobj overexpression,from
R7002 T23416 T23397 punct ", ",promotes
R7003 T23417 T23418 amod unscheduled,division
R7004 T23418 T23397 dobj division,promotes
R7005 T23419 T23418 compound cell,division
R7006 T23420 T23397 cc and,promotes
R7007 T23421 T23397 conj triggers,promotes
R7008 T23422 T23421 dobj apoptosis,triggers
R7009 T23423 T23421 prep in,triggers
R7010 T23424 T23425 amod susceptible,RTCs
R7011 T23425 T23423 pobj RTCs,in
R7012 T23426 T23397 punct .,promotes
R7013 T23428 T23429 nsubj E2f1,be
R7014 T23430 T23428 punct ", ",E2f1
R7015 T23431 T23432 advmod rather,than
R7016 T23432 T23428 cc than,E2f1
R7017 T23433 T23434 amod other,E2fs
R7018 T23434 T23428 conj E2fs,E2f1
R7019 T23435 T23429 punct ", ",be
R7020 T23436 T23429 aux may,be
R7021 T23437 T23438 det a,target
R7022 T23438 T23429 attr target,be
R7023 T23439 T23438 amod potential,target
R7024 T23440 T23438 prep for,target
R7025 T23441 T23442 amod novel,therapeutics
R7026 T23442 T23440 pobj therapeutics,for
R7027 T23443 T23444 aux to,prevent
R7028 T23444 T23442 advcl prevent,therapeutics
R7029 T23445 T23444 dobj retinoblastoma,prevent
R7030 T23446 T23444 prep in,prevent
R7031 T23447 T23448 nmod RB1,humans
R7032 T23448 T23446 pobj humans,in
R7033 T23449 T23447 punct +,RB1
R7034 T23450 T23447 punct /,RB1
R7035 T23451 T23447 punct −,RB1
R7036 T23452 T23429 punct .,be

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T22943 24-28 PR_EXT:000006852 denotes E2f1
T22944 29-37 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T22945 38-45 SO_EXT:sequence_rescue_process denotes rescues
T22946 46-50 CL_GO_EXT:cell denotes cell
T22947 80-85 GO:0016265 denotes death
T22948 91-106 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T22949 127-129 PR_EXT:000013773 denotes Rb
T22950 133-139 SO_EXT:sequence_cloned_entity denotes clones
T22951 162-172 NCBITaxon:11632 denotes retrovirus
T22952 173-179 SO_EXT:0000440 denotes vector
T22953 269-273 PR_EXT:000006852 denotes E2f1
T22954 278-288 GO:0010467 denotes expression
T22955 300-314 CL:0000210 denotes photoreceptors
T22956 343-352 GO:0006915 denotes apoptosis
T22957 407-411 PR_EXT:000006852 denotes E2f1
T22958 475-479 PR_EXT:E2F denotes E2fs
T22959 499-508 GO:0006915 denotes apoptosis
T22960 512-514 PR_EXT:000013773 denotes Rb
T22961 518-523 CL_GO_EXT:cell denotes cells
T22962 541-550 GO:0065007 denotes regulated
T22963 551-555 PR_EXT:000006852 denotes E2f1
T22964 572-578 UBERON:0000966 denotes retina
T22965 623-625 PR_EXT:000013773 denotes Rb
T22966 638-648 GO:0010467 denotes expression
T22967 671-675 CL_GO_EXT:cell denotes cell
T22968 671-684 GO:0051301 denotes cell division
T22969 698-707 GO:0006915 denotes apoptosis
T22970 729-733 PR_EXT:000006852 denotes E2f1
T22971 753-757 PR_EXT:E2F denotes E2fs
T22972 837-840 PR_EXT:000013773 denotes RB1
T22973 841-842 SO_EXT:normal_or_wild_type_or_present denotes +
T22974 843-844 SO_EXT:sequence_nullness_or_absence denotes −
T22975 845-851 NCBITaxon:9606 denotes humans

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T22824 24-28 PR:000006852 denotes E2f1
T22825 80-85 GO:0016265 denotes death
T22826 127-129 PR:000013773 denotes Rb
T22827 162-172 NCBITaxon:11632 denotes retrovirus
T22828 173-179 SO:0000440 denotes vector
T22829 269-273 PR:000006852 denotes E2f1
T22830 278-288 GO:0010467 denotes expression
T22831 300-314 CL:0000210 denotes photoreceptors
T22832 343-352 GO:0006915 denotes apoptosis
T22833 407-411 PR:000006852 denotes E2f1
T22834 499-508 GO:0006915 denotes apoptosis
T22835 512-514 PR:000013773 denotes Rb
T22836 541-550 GO:0065007 denotes regulated
T22837 551-555 PR:000006852 denotes E2f1
T22838 572-578 UBERON:0000966 denotes retina
T22839 623-625 PR:000013773 denotes Rb
T22840 638-648 GO:0010467 denotes expression
T22841 671-684 GO:0051301 denotes cell division
T22842 698-707 GO:0006915 denotes apoptosis
T22843 729-733 PR:000006852 denotes E2f1
T22844 837-840 PR:000013773 denotes RB1
T22845 845-851 NCBITaxon:9606 denotes humans

2_test

Id Subject Object Predicate Lexical cue
17608565-11704831-84869016 354-356 11704831 denotes 60
17608565-9207076-84869017 525-527 9207076 denotes 10
17608565-15976820-84869018 528-530 15976820 denotes 15
T68435 354-356 11704831 denotes 60
T81560 525-527 9207076 denotes 10
T56207 528-530 15976820 denotes 15