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PMC:1914394 / 43831-44641 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T23149 0-4 RB denotes Here
T23150 33-40 VBD denotes rescued
T23151 4-6 , denotes ,
T23152 6-14 VBG denotes deleting
T23153 15-19 NN denotes E2f1
T23154 20-32 RB denotes specifically
T23155 41-48 JJ denotes ectopic
T23156 49-57 NN denotes division
T23157 58-61 CC denotes and
T23158 62-67 NN denotes death
T23159 68-70 IN denotes in
T23160 71-74 DT denotes the
T23161 81-87 NN denotes retina
T23162 75-77 NN denotes Rb
T23163 78-80 NN denotes KO
T23164 87-88 . denotes .
T23165 88-302 sentence denotes Importantly, major Rb/E2f1 DKO neurons differentiated normally, and ERGs revealed the rescue of rod- and cone-mediated function, implicating a regular signal flow from photoreceptors to bipolar and amacrine cells.
T23166 89-100 RB denotes Importantly
T23167 128-142 VBD denotes differentiated
T23168 100-102 , denotes ,
T23169 102-107 JJ denotes major
T23170 120-127 NNS denotes neurons
T23171 108-110 NN denotes Rb
T23172 111-115 NN denotes E2f1
T23173 110-111 HYPH denotes /
T23174 116-119 NN denotes DKO
T23175 143-151 RB denotes normally
T23176 151-153 , denotes ,
T23177 153-156 CC denotes and
T23178 157-161 NNS denotes ERGs
T23179 162-170 VBD denotes revealed
T23180 171-174 DT denotes the
T23181 175-181 NN denotes rescue
T23182 182-184 IN denotes of
T23183 185-188 NN denotes rod
T23184 199-207 VBN denotes mediated
T23185 188-189 HYPH denotes -
T23186 190-193 CC denotes and
T23187 194-198 NN denotes cone
T23188 198-199 HYPH denotes -
T23189 208-216 NN denotes function
T23190 216-218 , denotes ,
T23191 218-229 VBG denotes implicating
T23192 230-231 DT denotes a
T23193 247-251 NN denotes flow
T23194 232-239 JJ denotes regular
T23195 240-246 NN denotes signal
T23196 252-256 IN denotes from
T23197 257-271 NNS denotes photoreceptors
T23198 272-274 IN denotes to
T23199 275-282 JJ denotes bipolar
T23200 296-301 NNS denotes cells
T23201 283-286 CC denotes and
T23202 287-295 JJ denotes amacrine
T23203 301-302 . denotes .
T23204 302-430 sentence denotes Division and death genes were induced in Rb KO cells, and deleting E2f1, but not E2f2 or E2f3, reversed these molecular events.
T23205 303-311 NN denotes Division
T23206 322-327 NNS denotes genes
T23207 312-315 CC denotes and
T23208 316-321 NN denotes death
T23209 333-340 VBN denotes induced
T23210 328-332 VBD denotes were
T23211 341-343 IN denotes in
T23212 344-346 NN denotes Rb
T23213 347-349 NN denotes KO
T23214 350-355 NNS denotes cells
T23215 355-357 , denotes ,
T23216 357-360 CC denotes and
T23217 361-369 VBG denotes deleting
T23218 398-406 VBD denotes reversed
T23219 370-374 NN denotes E2f1
T23220 374-376 , denotes ,
T23221 376-379 CC denotes but
T23222 380-383 RB denotes not
T23223 384-388 NN denotes E2f2
T23224 389-391 CC denotes or
T23225 392-396 NN denotes E2f3
T23226 396-398 , denotes ,
T23227 407-412 DT denotes these
T23228 423-429 NNS denotes events
T23229 413-422 JJ denotes molecular
T23230 429-430 . denotes .
T23231 430-645 sentence denotes E2f1 may also regulate differentiation targets, but whether this contributes to defects in retinal cell maturation is impossible to separate from potentially indirect consequences of deregulated division and death.
T23232 431-435 NN denotes E2f1
T23233 445-453 VB denotes regulate
T23234 436-439 MD denotes may
T23235 440-444 RB denotes also
T23236 454-469 NN denotes differentiation
T23237 470-477 NNS denotes targets
T23238 477-479 , denotes ,
T23239 479-482 CC denotes but
T23240 483-490 IN denotes whether
T23241 496-507 VBZ denotes contributes
T23242 491-495 DT denotes this
T23243 546-548 VBZ denotes is
T23244 508-510 IN denotes to
T23245 511-518 NNS denotes defects
T23246 519-521 IN denotes in
T23247 522-529 JJ denotes retinal
T23248 530-534 NN denotes cell
T23249 535-545 NN denotes maturation
T23250 549-559 JJ denotes impossible
T23251 560-562 TO denotes to
T23252 563-571 VB denotes separate
T23253 572-576 IN denotes from
T23254 577-588 RB denotes potentially
T23255 589-597 JJ denotes indirect
T23256 598-610 NNS denotes consequences
T23257 611-613 IN denotes of
T23258 614-625 VBN denotes deregulated
T23259 626-634 NN denotes division
T23260 635-638 CC denotes and
T23261 639-644 NN denotes death
T23262 644-645 . denotes .
T23263 645-810 sentence denotes In any case, it is clear that in most retinal cells, including photoreceptors [29], transcription factors that promote differentiation function independently of Rb.
T23264 646-648 IN denotes In
T23265 662-664 VBZ denotes is
T23266 649-652 DT denotes any
T23267 653-657 NN denotes case
T23268 657-659 , denotes ,
T23269 659-661 PRP denotes it
T23270 665-670 JJ denotes clear
T23271 671-675 IN denotes that
T23272 781-789 VBZ denotes function
T23273 676-678 IN denotes in
T23274 679-683 JJS denotes most
T23275 692-697 NNS denotes cells
T23276 684-691 JJ denotes retinal
T23277 697-699 , denotes ,
T23278 699-708 VBG denotes including
T23279 709-723 NNS denotes photoreceptors
T23280 724-725 -LRB- denotes [
T23281 725-727 CD denotes 29
T23282 727-728 -RRB- denotes ]
T23283 728-730 , denotes ,
T23284 730-743 NN denotes transcription
T23285 744-751 NNS denotes factors
T23286 752-756 WDT denotes that
T23287 757-764 VBP denotes promote
T23288 765-780 NN denotes differentiation
T23289 790-803 RB denotes independently
T23290 804-806 IN denotes of
T23291 807-809 NN denotes Rb
T23292 809-810 . denotes .
R6750 T23149 T23150 advmod Here,rescued
R6751 T23151 T23150 punct ", ",rescued
R6752 T23152 T23150 csubj deleting,rescued
R6753 T23153 T23152 dobj E2f1,deleting
R6754 T23154 T23150 advmod specifically,rescued
R6755 T23155 T23156 amod ectopic,division
R6756 T23156 T23150 dobj division,rescued
R6757 T23157 T23156 cc and,division
R6758 T23158 T23156 conj death,division
R6759 T23159 T23150 prep in,rescued
R6760 T23160 T23161 det the,retina
R6761 T23161 T23159 pobj retina,in
R6762 T23162 T23163 compound Rb,KO
R6763 T23163 T23161 compound KO,retina
R6764 T23164 T23150 punct .,rescued
R6765 T23166 T23167 advmod Importantly,differentiated
R6766 T23168 T23167 punct ", ",differentiated
R6767 T23169 T23170 amod major,neurons
R6768 T23170 T23167 nsubj neurons,differentiated
R6769 T23171 T23172 compound Rb,E2f1
R6770 T23172 T23174 compound E2f1,DKO
R6771 T23173 T23172 punct /,E2f1
R6772 T23174 T23170 compound DKO,neurons
R6773 T23175 T23167 advmod normally,differentiated
R6774 T23176 T23167 punct ", ",differentiated
R6775 T23177 T23167 cc and,differentiated
R6776 T23178 T23179 nsubj ERGs,revealed
R6777 T23179 T23167 conj revealed,differentiated
R6778 T23180 T23181 det the,rescue
R6779 T23181 T23179 dobj rescue,revealed
R6780 T23182 T23181 prep of,rescue
R6781 T23183 T23184 npadvmod rod,mediated
R6782 T23184 T23189 amod mediated,function
R6783 T23185 T23183 punct -,rod
R6784 T23186 T23183 cc and,rod
R6785 T23187 T23183 conj cone,rod
R6786 T23188 T23184 punct -,mediated
R6787 T23189 T23182 pobj function,of
R6788 T23190 T23179 punct ", ",revealed
R6789 T23191 T23179 advcl implicating,revealed
R6790 T23192 T23193 det a,flow
R6791 T23193 T23191 dobj flow,implicating
R6792 T23194 T23193 amod regular,flow
R6793 T23195 T23193 compound signal,flow
R6794 T23196 T23193 prep from,flow
R6795 T23197 T23196 pobj photoreceptors,from
R6796 T23198 T23193 prep to,flow
R6797 T23199 T23200 amod bipolar,cells
R6798 T23200 T23198 pobj cells,to
R6799 T23201 T23199 cc and,bipolar
R6800 T23202 T23199 conj amacrine,bipolar
R6801 T23203 T23179 punct .,revealed
R6802 T23205 T23206 nmod Division,genes
R6803 T23206 T23209 nsubjpass genes,induced
R6804 T23207 T23205 cc and,Division
R6805 T23208 T23205 conj death,Division
R6806 T23210 T23209 auxpass were,induced
R6807 T23211 T23209 prep in,induced
R6808 T23212 T23213 compound Rb,KO
R6809 T23213 T23214 compound KO,cells
R6810 T23214 T23211 pobj cells,in
R6811 T23215 T23209 punct ", ",induced
R6812 T23216 T23209 cc and,induced
R6813 T23217 T23218 csubj deleting,reversed
R6814 T23218 T23209 conj reversed,induced
R6815 T23219 T23217 dobj E2f1,deleting
R6816 T23220 T23219 punct ", ",E2f1
R6817 T23221 T23219 cc but,E2f1
R6818 T23222 T23221 neg not,but
R6819 T23223 T23219 conj E2f2,E2f1
R6820 T23224 T23223 cc or,E2f2
R6821 T23225 T23223 conj E2f3,E2f2
R6822 T23226 T23218 punct ", ",reversed
R6823 T23227 T23228 det these,events
R6824 T23228 T23218 dobj events,reversed
R6825 T23229 T23228 amod molecular,events
R6826 T23230 T23218 punct .,reversed
R6827 T23232 T23233 nsubj E2f1,regulate
R6828 T23234 T23233 aux may,regulate
R6829 T23235 T23233 advmod also,regulate
R6830 T23236 T23237 compound differentiation,targets
R6831 T23237 T23233 dobj targets,regulate
R6832 T23238 T23233 punct ", ",regulate
R6833 T23239 T23233 cc but,regulate
R6834 T23240 T23241 mark whether,contributes
R6835 T23241 T23243 csubj contributes,is
R6836 T23242 T23241 nsubj this,contributes
R6837 T23243 T23233 conj is,regulate
R6838 T23244 T23241 prep to,contributes
R6839 T23245 T23244 pobj defects,to
R6840 T23246 T23245 prep in,defects
R6841 T23247 T23248 amod retinal,cell
R6842 T23248 T23249 compound cell,maturation
R6843 T23249 T23246 pobj maturation,in
R6844 T23250 T23243 acomp impossible,is
R6845 T23251 T23252 aux to,separate
R6846 T23252 T23250 xcomp separate,impossible
R6847 T23253 T23252 prep from,separate
R6848 T23254 T23255 advmod potentially,indirect
R6849 T23255 T23256 amod indirect,consequences
R6850 T23256 T23253 pobj consequences,from
R6851 T23257 T23256 prep of,consequences
R6852 T23258 T23259 amod deregulated,division
R6853 T23259 T23257 pobj division,of
R6854 T23260 T23259 cc and,division
R6855 T23261 T23259 conj death,division
R6856 T23262 T23243 punct .,is
R6857 T23264 T23265 prep In,is
R6858 T23266 T23267 det any,case
R6859 T23267 T23264 pobj case,In
R6860 T23268 T23265 punct ", ",is
R6861 T23269 T23265 nsubj it,is
R6862 T23270 T23265 acomp clear,is
R6863 T23271 T23272 mark that,function
R6864 T23272 T23265 ccomp function,is
R6865 T23273 T23272 prep in,function
R6866 T23274 T23275 amod most,cells
R6867 T23275 T23273 pobj cells,in
R6868 T23276 T23275 amod retinal,cells
R6869 T23277 T23275 punct ", ",cells
R6870 T23278 T23275 prep including,cells
R6871 T23279 T23278 pobj photoreceptors,including
R6872 T23280 T23281 punct [,29
R6873 T23281 T23275 parataxis 29,cells
R6874 T23282 T23281 punct ],29
R6875 T23283 T23272 punct ", ",function
R6876 T23284 T23285 compound transcription,factors
R6877 T23285 T23272 nsubj factors,function
R6878 T23286 T23287 dep that,promote
R6879 T23287 T23285 relcl promote,factors
R6880 T23288 T23287 dobj differentiation,promote
R6881 T23289 T23272 advmod independently,function
R6882 T23290 T23289 prep of,independently
R6883 T23291 T23290 pobj Rb,of
R6884 T23292 T23265 punct .,is

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T22898 6-14 SO_EXT:sequence_deletion_process denotes deleting
T22899 15-19 PR_EXT:000006852 denotes E2f1
T22900 33-40 SO_EXT:sequence_rescue_process denotes rescued
T22901 62-67 GO:0016265 denotes death
T22902 75-77 PR_EXT:000013773 denotes Rb
T22903 81-87 UBERON:0000966 denotes retina
T22904 108-110 PR_EXT:000013773 denotes Rb
T22905 111-115 PR_EXT:000006852 denotes E2f1
T22906 120-127 CL:0000540 denotes neurons
T22907 128-142 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T22908 175-181 SO_EXT:sequence_rescue_process denotes rescue
T22909 185-188 CL:0000604 denotes rod
T22910 194-198 CL:0000573 denotes cone
T22911 240-251 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signal flow
T22912 257-271 CL:0000210 denotes photoreceptors
T22913 275-282 _FRAGMENT denotes bipolar
T22914 296-301 CL:0000103 denotes cells
T22915 287-301 CL:0000561 denotes amacrine cells
T22916 296-301 CL_GO_EXT:cell denotes cells
T22917 316-321 GO:0016265 denotes death
T22918 322-327 SO_EXT:0000704 denotes genes
T22919 344-346 PR_EXT:000013773 denotes Rb
T22920 350-355 CL_GO_EXT:cell denotes cells
T22921 361-369 SO_EXT:sequence_deletion_process denotes deleting
T22922 370-374 PR_EXT:000006852 denotes E2f1
T22923 384-388 PR_EXT:000006853 denotes E2f2
T22924 392-396 PR_EXT:000006854 denotes E2f3
T22925 413-422 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T22926 431-435 PR_EXT:000006852 denotes E2f1
T22927 445-453 GO:0065007 denotes regulate
T22928 454-469 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T22929 522-529 UBERON:0000966 denotes retinal
T22930 522-534 CL:0009004 denotes retinal cell
T22931 530-534 CL_GO_EXT:cell denotes cell
T22932 530-545 GO:0048469 denotes cell maturation
T22933 616-625 GO:0065007 denotes regulated
T22934 639-644 GO:0016265 denotes death
T22935 684-691 UBERON:0000966 denotes retinal
T22936 684-697 CL:0009004 denotes retinal cells
T22937 692-697 CL_GO_EXT:cell denotes cells
T22938 709-723 CL:0000210 denotes photoreceptors
T22939 730-743 GO_EXT:transcription denotes transcription
T22940 730-751 GO_EXT:transcription_factor denotes transcription factors
T22941 765-780 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T22942 807-809 PR_EXT:000013773 denotes Rb
R6613 T22914 T22913 _lexicallyChainedTo cells,bipolar

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T22813 431-435 PR:000006852 denotes E2f1
T22814 445-453 GO:0065007 denotes regulate
T22815 522-529 UBERON:0000966 denotes retinal
T22816 522-534 CL:0009004 denotes retinal cell
T22817 530-545 GO:0048469 denotes cell maturation
T22818 616-625 GO:0065007 denotes regulated
T22819 639-644 GO:0016265 denotes death
T22820 684-691 UBERON:0000966 denotes retinal
T22794 15-19 PR:000006852 denotes E2f1
T22795 62-67 GO:0016265 denotes death
T22796 75-77 PR:000013773 denotes Rb
T22797 81-87 UBERON:0000966 denotes retina
T22798 108-110 PR:000013773 denotes Rb
T22799 111-115 PR:000006852 denotes E2f1
T22800 120-127 CL:0000540 denotes neurons
T22801 185-188 CL:0000604 denotes rod
T22802 194-198 CL:0000573 denotes cone
T22803 257-271 CL:0000210 denotes photoreceptors
T22804 275-282 _FRAGMENT denotes bipolar
T22805 296-301 CL:0000103 denotes cells
T22806 287-301 CL:0000561 denotes amacrine cells
T22807 316-321 GO:0016265 denotes death
T22808 322-327 SO:0000704 denotes genes
T22809 344-346 PR:000013773 denotes Rb
T22810 370-374 PR:000006852 denotes E2f1
T22811 384-388 PR:000006853 denotes E2f2
T22812 392-396 PR:000006854 denotes E2f3
T22821 684-697 CL:0009004 denotes retinal cells
T22822 709-723 CL:0000210 denotes photoreceptors
T22823 807-809 PR:000013773 denotes Rb
R6609 T22805 T22804 _lexicallyChainedTo cells,bipolar

2_test

Id Subject Object Predicate Lexical cue
17608565-14991054-84869015 725-727 14991054 denotes 29
T75521 725-727 14991054 denotes 29