PMC:1914394 / 43164-43830
Annnotations
craft-sa-dev
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T23013 | 0-4 | NN | denotes | Work |
T23014 | 24-30 | VBD | denotes | showed |
T23015 | 5-7 | IN | denotes | in |
T23016 | 8-11 | DT | denotes | the |
T23017 | 18-23 | NNS | denotes | 1990s |
T23018 | 12-17 | JJ | denotes | early |
T23019 | 31-35 | IN | denotes | that |
T23020 | 44-52 | VBZ | denotes | triggers |
T23021 | 36-38 | NN | denotes | Rb |
T23022 | 39-43 | NN | denotes | loss |
T23023 | 53-60 | NNS | denotes | defects |
T23024 | 61-63 | IN | denotes | in |
T23025 | 64-72 | JJ | denotes | neuronal |
T23026 | 84-88 | NN | denotes | exit |
T23027 | 73-77 | NN | denotes | cell |
T23028 | 78-83 | NN | denotes | cycle |
T23029 | 88-90 | , | denotes | , |
T23030 | 90-98 | NN | denotes | survival |
T23031 | 98-100 | , | denotes | , |
T23032 | 100-103 | CC | denotes | and |
T23033 | 104-119 | NN | denotes | differentiation |
T23034 | 120-121 | -LRB- | denotes | [ |
T23035 | 121-123 | CD | denotes | 26 |
T23036 | 123-124 | SYM | denotes | – |
T23037 | 124-126 | CD | denotes | 28 |
T23038 | 126-127 | -RRB- | denotes | ] |
T23039 | 127-128 | . | denotes | . |
T23040 | 128-230 | sentence | denotes | Much of the death is an indirect consequence of probable hypoxia linked to placental defects [12–14]. |
T23041 | 129-133 | JJ | denotes | Much |
T23042 | 147-149 | VBZ | denotes | is |
T23043 | 134-136 | IN | denotes | of |
T23044 | 137-140 | DT | denotes | the |
T23045 | 141-146 | NN | denotes | death |
T23046 | 150-152 | DT | denotes | an |
T23047 | 162-173 | NN | denotes | consequence |
T23048 | 153-161 | JJ | denotes | indirect |
T23049 | 174-176 | IN | denotes | of |
T23050 | 177-185 | JJ | denotes | probable |
T23051 | 186-193 | NN | denotes | hypoxia |
T23052 | 194-200 | VBN | denotes | linked |
T23053 | 201-203 | IN | denotes | to |
T23054 | 204-213 | JJ | denotes | placental |
T23055 | 214-221 | NNS | denotes | defects |
T23056 | 222-223 | -LRB- | denotes | [ |
T23057 | 223-225 | CD | denotes | 12 |
T23058 | 225-226 | SYM | denotes | – |
T23059 | 226-228 | CD | denotes | 14 |
T23060 | 228-229 | -RRB- | denotes | ] |
T23061 | 229-230 | . | denotes | . |
T23062 | 230-444 | sentence | denotes | However, targeted KO and chimeric studies reveal that Rb autonomously promotes cell cycle exit in newborn neurons, and is required for survival of a subset of neurons, particularly in the retina [2,3,13,14,56–59]. |
T23063 | 231-238 | RB | denotes | However |
T23064 | 273-279 | VBP | denotes | reveal |
T23065 | 238-240 | , | denotes | , |
T23066 | 240-248 | VBN | denotes | targeted |
T23067 | 249-251 | NN | denotes | KO |
T23068 | 265-272 | NNS | denotes | studies |
T23069 | 252-255 | CC | denotes | and |
T23070 | 256-264 | JJ | denotes | chimeric |
T23071 | 280-284 | IN | denotes | that |
T23072 | 301-309 | VBZ | denotes | promotes |
T23073 | 285-287 | NN | denotes | Rb |
T23074 | 288-300 | RB | denotes | autonomously |
T23075 | 310-314 | NN | denotes | cell |
T23076 | 315-320 | NN | denotes | cycle |
T23077 | 321-325 | NN | denotes | exit |
T23078 | 326-328 | IN | denotes | in |
T23079 | 329-336 | JJ | denotes | newborn |
T23080 | 337-344 | NNS | denotes | neurons |
T23081 | 344-346 | , | denotes | , |
T23082 | 346-349 | CC | denotes | and |
T23083 | 350-352 | VBZ | denotes | is |
T23084 | 353-361 | VBN | denotes | required |
T23085 | 362-365 | IN | denotes | for |
T23086 | 366-374 | NN | denotes | survival |
T23087 | 375-377 | IN | denotes | of |
T23088 | 378-379 | DT | denotes | a |
T23089 | 380-386 | NN | denotes | subset |
T23090 | 387-389 | IN | denotes | of |
T23091 | 390-397 | NNS | denotes | neurons |
T23092 | 397-399 | , | denotes | , |
T23093 | 399-411 | RB | denotes | particularly |
T23094 | 412-414 | IN | denotes | in |
T23095 | 415-418 | DT | denotes | the |
T23096 | 419-425 | NN | denotes | retina |
T23097 | 426-427 | -LRB- | denotes | [ |
T23098 | 427-428 | CD | denotes | 2 |
T23099 | 428-429 | , | denotes | , |
T23100 | 429-430 | CD | denotes | 3 |
T23101 | 430-431 | , | denotes | , |
T23102 | 431-433 | CD | denotes | 13 |
T23103 | 433-434 | , | denotes | , |
T23104 | 434-436 | CD | denotes | 14 |
T23105 | 436-437 | , | denotes | , |
T23106 | 437-439 | CD | denotes | 56 |
T23107 | 439-440 | SYM | denotes | – |
T23108 | 440-442 | CD | denotes | 59 |
T23109 | 442-443 | -RRB- | denotes | ] |
T23110 | 443-444 | . | denotes | . |
T23111 | 444-570 | sentence | denotes | However, whether Rb also regulates differentiation is obscured by potentially indirect effects of ectopic division and death. |
T23112 | 445-452 | RB | denotes | However |
T23113 | 499-507 | VBN | denotes | obscured |
T23114 | 452-454 | , | denotes | , |
T23115 | 454-461 | IN | denotes | whether |
T23116 | 470-479 | VBZ | denotes | regulates |
T23117 | 462-464 | NN | denotes | Rb |
T23118 | 465-469 | RB | denotes | also |
T23119 | 480-495 | NN | denotes | differentiation |
T23120 | 496-498 | VBZ | denotes | is |
T23121 | 508-510 | IN | denotes | by |
T23122 | 511-522 | RB | denotes | potentially |
T23123 | 523-531 | JJ | denotes | indirect |
T23124 | 532-539 | NNS | denotes | effects |
T23125 | 540-542 | IN | denotes | of |
T23126 | 543-550 | JJ | denotes | ectopic |
T23127 | 551-559 | NN | denotes | division |
T23128 | 560-563 | CC | denotes | and |
T23129 | 564-569 | NN | denotes | death |
T23130 | 569-570 | . | denotes | . |
T23131 | 570-666 | sentence | denotes | Moreover, a mechanism though which Rb may regulate neuronal maturation has not been elucidated. |
T23132 | 571-579 | RB | denotes | Moreover |
T23133 | 655-665 | VBN | denotes | elucidated |
T23134 | 579-581 | , | denotes | , |
T23135 | 581-582 | DT | denotes | a |
T23136 | 583-592 | NN | denotes | mechanism |
T23137 | 593-599 | IN | denotes | though |
T23138 | 613-621 | VB | denotes | regulate |
T23139 | 600-605 | WDT | denotes | which |
T23140 | 606-608 | NN | denotes | Rb |
T23141 | 609-612 | MD | denotes | may |
T23142 | 622-630 | JJ | denotes | neuronal |
T23143 | 631-641 | NN | denotes | maturation |
T23144 | 642-645 | VBZ | denotes | has |
T23145 | 646-649 | RB | denotes | not |
T23146 | 650-654 | VBN | denotes | been |
T23147 | 665-666 | . | denotes | . |
R6624 | T23013 | T23014 | nsubj | Work,showed |
R6625 | T23015 | T23013 | prep | in,Work |
R6626 | T23016 | T23017 | det | the,1990s |
R6627 | T23017 | T23015 | pobj | 1990s,in |
R6628 | T23018 | T23017 | amod | early,1990s |
R6629 | T23019 | T23020 | mark | that,triggers |
R6630 | T23020 | T23014 | ccomp | triggers,showed |
R6631 | T23021 | T23022 | compound | Rb,loss |
R6632 | T23022 | T23020 | nsubj | loss,triggers |
R6633 | T23023 | T23020 | dobj | defects,triggers |
R6634 | T23024 | T23023 | prep | in,defects |
R6635 | T23025 | T23026 | amod | neuronal,exit |
R6636 | T23026 | T23024 | pobj | exit,in |
R6637 | T23027 | T23028 | compound | cell,cycle |
R6638 | T23028 | T23026 | compound | cycle,exit |
R6639 | T23029 | T23026 | punct | ", ",exit |
R6640 | T23030 | T23026 | conj | survival,exit |
R6641 | T23031 | T23030 | punct | ", ",survival |
R6642 | T23032 | T23030 | cc | and,survival |
R6643 | T23033 | T23030 | conj | differentiation,survival |
R6644 | T23034 | T23035 | punct | [,26 |
R6645 | T23035 | T23020 | parataxis | 26,triggers |
R6646 | T23036 | T23037 | punct | –,28 |
R6647 | T23037 | T23035 | prep | 28,26 |
R6648 | T23038 | T23035 | punct | ],26 |
R6649 | T23039 | T23014 | punct | .,showed |
R6650 | T23041 | T23042 | nsubj | Much,is |
R6651 | T23043 | T23041 | prep | of,Much |
R6652 | T23044 | T23045 | det | the,death |
R6653 | T23045 | T23043 | pobj | death,of |
R6654 | T23046 | T23047 | det | an,consequence |
R6655 | T23047 | T23042 | attr | consequence,is |
R6656 | T23048 | T23047 | amod | indirect,consequence |
R6657 | T23049 | T23047 | prep | of,consequence |
R6658 | T23050 | T23051 | amod | probable,hypoxia |
R6659 | T23051 | T23049 | pobj | hypoxia,of |
R6660 | T23052 | T23051 | acl | linked,hypoxia |
R6661 | T23053 | T23052 | prep | to,linked |
R6662 | T23054 | T23055 | amod | placental,defects |
R6663 | T23055 | T23053 | pobj | defects,to |
R6664 | T23056 | T23057 | punct | [,12 |
R6665 | T23057 | T23052 | parataxis | 12,linked |
R6666 | T23058 | T23059 | punct | –,14 |
R6667 | T23059 | T23057 | prep | 14,12 |
R6668 | T23060 | T23057 | punct | ],12 |
R6669 | T23061 | T23042 | punct | .,is |
R6670 | T23063 | T23064 | advmod | However,reveal |
R6671 | T23065 | T23064 | punct | ", ",reveal |
R6672 | T23066 | T23067 | amod | targeted,KO |
R6673 | T23067 | T23068 | nmod | KO,studies |
R6674 | T23068 | T23064 | nsubj | studies,reveal |
R6675 | T23069 | T23067 | cc | and,KO |
R6676 | T23070 | T23067 | conj | chimeric,KO |
R6677 | T23071 | T23072 | mark | that,promotes |
R6678 | T23072 | T23064 | ccomp | promotes,reveal |
R6679 | T23073 | T23072 | nsubj | Rb,promotes |
R6680 | T23074 | T23072 | advmod | autonomously,promotes |
R6681 | T23075 | T23076 | compound | cell,cycle |
R6682 | T23076 | T23077 | compound | cycle,exit |
R6683 | T23077 | T23072 | dobj | exit,promotes |
R6684 | T23078 | T23072 | prep | in,promotes |
R6685 | T23079 | T23080 | amod | newborn,neurons |
R6686 | T23080 | T23078 | pobj | neurons,in |
R6687 | T23081 | T23072 | punct | ", ",promotes |
R6688 | T23082 | T23072 | cc | and,promotes |
R6689 | T23083 | T23084 | auxpass | is,required |
R6690 | T23084 | T23072 | conj | required,promotes |
R6691 | T23085 | T23084 | prep | for,required |
R6692 | T23086 | T23085 | pobj | survival,for |
R6693 | T23087 | T23086 | prep | of,survival |
R6694 | T23088 | T23089 | det | a,subset |
R6695 | T23089 | T23087 | pobj | subset,of |
R6696 | T23090 | T23089 | prep | of,subset |
R6697 | T23091 | T23090 | pobj | neurons,of |
R6698 | T23092 | T23084 | punct | ", ",required |
R6699 | T23093 | T23094 | advmod | particularly,in |
R6700 | T23094 | T23084 | prep | in,required |
R6701 | T23095 | T23096 | det | the,retina |
R6702 | T23096 | T23094 | pobj | retina,in |
R6703 | T23097 | T23098 | punct | [,2 |
R6704 | T23098 | T23064 | parataxis | 2,reveal |
R6705 | T23099 | T23098 | punct | ",",2 |
R6706 | T23100 | T23098 | appos | 3,2 |
R6707 | T23101 | T23098 | punct | ",",2 |
R6708 | T23102 | T23098 | appos | 13,2 |
R6709 | T23103 | T23098 | punct | ",",2 |
R6710 | T23104 | T23098 | appos | 14,2 |
R6711 | T23105 | T23098 | punct | ",",2 |
R6712 | T23106 | T23098 | appos | 56,2 |
R6713 | T23107 | T23108 | punct | –,59 |
R6714 | T23108 | T23106 | prep | 59,56 |
R6715 | T23109 | T23098 | punct | ],2 |
R6716 | T23110 | T23064 | punct | .,reveal |
R6717 | T23112 | T23113 | advmod | However,obscured |
R6718 | T23114 | T23113 | punct | ", ",obscured |
R6719 | T23115 | T23116 | mark | whether,regulates |
R6720 | T23116 | T23113 | csubjpass | regulates,obscured |
R6721 | T23117 | T23116 | nsubj | Rb,regulates |
R6722 | T23118 | T23116 | advmod | also,regulates |
R6723 | T23119 | T23116 | dobj | differentiation,regulates |
R6724 | T23120 | T23113 | auxpass | is,obscured |
R6725 | T23121 | T23113 | agent | by,obscured |
R6726 | T23122 | T23123 | advmod | potentially,indirect |
R6727 | T23123 | T23124 | amod | indirect,effects |
R6728 | T23124 | T23121 | pobj | effects,by |
R6729 | T23125 | T23124 | prep | of,effects |
R6730 | T23126 | T23127 | amod | ectopic,division |
R6731 | T23127 | T23125 | pobj | division,of |
R6732 | T23128 | T23127 | cc | and,division |
R6733 | T23129 | T23127 | conj | death,division |
R6734 | T23130 | T23113 | punct | .,obscured |
R6735 | T23132 | T23133 | advmod | Moreover,elucidated |
R6736 | T23134 | T23133 | punct | ", ",elucidated |
R6737 | T23135 | T23136 | det | a,mechanism |
R6738 | T23136 | T23133 | nsubjpass | mechanism,elucidated |
R6739 | T23137 | T23138 | prep | though,regulate |
R6740 | T23138 | T23136 | relcl | regulate,mechanism |
R6741 | T23139 | T23137 | pobj | which,though |
R6742 | T23140 | T23138 | nsubj | Rb,regulate |
R6743 | T23141 | T23138 | aux | may,regulate |
R6744 | T23142 | T23143 | amod | neuronal,maturation |
R6745 | T23143 | T23138 | dobj | maturation,regulate |
R6746 | T23144 | T23133 | aux | has,elucidated |
R6747 | T23145 | T23133 | neg | not,elucidated |
R6748 | T23146 | T23133 | auxpass | been,elucidated |
R6749 | T23147 | T23133 | punct | .,elucidated |
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22877 | 36-38 | PR_EXT:000013773 | denotes | Rb |
T22878 | 64-72 | CL:0000540 | denotes | neuronal |
T22879 | 73-77 | CL_GO_EXT:cell | denotes | cell |
T22880 | 73-83 | GO:0007049 | denotes | cell cycle |
T22881 | 104-119 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
T22882 | 141-146 | GO:0016265 | denotes | death |
T22883 | 204-213 | UBERON:0001987 | denotes | placental |
T22884 | 285-287 | PR_EXT:000013773 | denotes | Rb |
T22885 | 310-314 | CL_GO_EXT:cell | denotes | cell |
T22886 | 310-320 | GO:0007049 | denotes | cell cycle |
T22887 | 337-344 | CL:0000540 | denotes | neurons |
T22888 | 390-397 | CL:0000540 | denotes | neurons |
T22889 | 419-425 | UBERON:0000966 | denotes | retina |
T22890 | 462-464 | PR_EXT:000013773 | denotes | Rb |
T22891 | 470-479 | GO:0065007 | denotes | regulates |
T22892 | 480-495 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
T22893 | 564-569 | GO:0016265 | denotes | death |
T22894 | 606-608 | PR_EXT:000013773 | denotes | Rb |
T22895 | 613-621 | GO:0065007 | denotes | regulate |
T22896 | 622-630 | CL:0000540 | denotes | neuronal |
T22897 | 622-641 | GO:0042551 | denotes | neuronal maturation |
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22777 | 36-38 | PR:000013773 | denotes | Rb |
T22778 | 64-72 | CL:0000540 | denotes | neuronal |
T22779 | 73-83 | GO:0007049 | denotes | cell cycle |
T22780 | 141-146 | GO:0016265 | denotes | death |
T22781 | 204-213 | UBERON:0001987 | denotes | placental |
T22782 | 285-287 | PR:000013773 | denotes | Rb |
T22783 | 310-320 | GO:0007049 | denotes | cell cycle |
T22784 | 337-344 | CL:0000540 | denotes | neurons |
T22785 | 390-397 | CL:0000540 | denotes | neurons |
T22786 | 419-425 | UBERON:0000966 | denotes | retina |
T22787 | 462-464 | PR:000013773 | denotes | Rb |
T22788 | 470-479 | GO:0065007 | denotes | regulates |
T22789 | 564-569 | GO:0016265 | denotes | death |
T22790 | 606-608 | PR:000013773 | denotes | Rb |
T22791 | 613-621 | GO:0065007 | denotes | regulate |
T22792 | 622-630 | CL:0000540 | denotes | neuronal |
T22793 | 622-641 | GO:0042551 | denotes | neuronal maturation |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
17608565-1406933-84869008 | 121-123 | 1406933 | denotes | 26 |
17608565-1406932-84869008 | 121-123 | 1406932 | denotes | 26 |
17608565-7958874-84869008 | 121-123 | 7958874 | denotes | 26 |
17608565-12607001-84869009 | 223-225 | 12607001 | denotes | 12 |
17608565-12093735-84869009 | 223-225 | 12093735 | denotes | 12 |
17608565-12529408-84869009 | 223-225 | 12529408 | denotes | 12 |
17608565-15193257-84869010 | 427-428 | 15193257 | denotes | 2 |
17608565-15231717-84869011 | 429-430 | 15231717 | denotes | 3 |
17608565-12093735-84869012 | 431-433 | 12093735 | denotes | 13 |
17608565-12529408-84869013 | 434-436 | 12529408 | denotes | 14 |
17608565-7925271-84869014 | 437-439 | 7925271 | denotes | 56 |
17608565-9620848-84869014 | 437-439 | 9620848 | denotes | 56 |
17608565-9508781-84869014 | 437-439 | 9508781 | denotes | 56 |
17608565-11435948-84869014 | 437-439 | 11435948 | denotes | 56 |
T50692 | 121-123 | 1406933 | denotes | 26 |
T8827 | 121-123 | 1406932 | denotes | 26 |
T66937 | 121-123 | 7958874 | denotes | 26 |
T49577 | 223-225 | 12607001 | denotes | 12 |
T76010 | 223-225 | 12093735 | denotes | 12 |
T58357 | 223-225 | 12529408 | denotes | 12 |
T97555 | 427-428 | 15193257 | denotes | 2 |
T34975 | 429-430 | 15231717 | denotes | 3 |
T7298 | 431-433 | 12093735 | denotes | 13 |
T34038 | 434-436 | 12529408 | denotes | 14 |
T64450 | 437-439 | 7925271 | denotes | 56 |
T10775 | 437-439 | 9620848 | denotes | 56 |
T80701 | 437-439 | 9508781 | denotes | 56 |
T43950 | 437-439 | 11435948 | denotes | 56 |