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Id Subject Object Predicate Lexical cue
T23003 0-2 NN denotes Rb
T23004 3-11 VBZ denotes Controls
T23005 12-19 JJ denotes Retinal
T23006 20-24 NN denotes Cell
T23007 25-33 NN denotes Division
T23008 34-37 CC denotes and
T23009 38-43 NN denotes Death
T23010 44-51 IN denotes through
T23011 52-56 NN denotes E2f1
T23012 56-185 sentence denotes Work in the early 1990s showed that Rb loss triggers defects in neuronal cell cycle exit, survival, and differentiation [26–28].
T23013 57-61 NN denotes Work
T23014 81-87 VBD denotes showed
T23015 62-64 IN denotes in
T23016 65-68 DT denotes the
T23017 75-80 NNS denotes 1990s
T23018 69-74 JJ denotes early
T23019 88-92 IN denotes that
T23020 101-109 VBZ denotes triggers
T23021 93-95 NN denotes Rb
T23022 96-100 NN denotes loss
T23023 110-117 NNS denotes defects
T23024 118-120 IN denotes in
T23025 121-129 JJ denotes neuronal
T23026 141-145 NN denotes exit
T23027 130-134 NN denotes cell
T23028 135-140 NN denotes cycle
T23029 145-147 , denotes ,
T23030 147-155 NN denotes survival
T23031 155-157 , denotes ,
T23032 157-160 CC denotes and
T23033 161-176 NN denotes differentiation
T23034 177-178 -LRB- denotes [
T23035 178-180 CD denotes 26
T23036 180-181 SYM denotes –
T23037 181-183 CD denotes 28
T23038 183-184 -RRB- denotes ]
T23039 184-185 . denotes .
T23040 185-287 sentence denotes Much of the death is an indirect consequence of probable hypoxia linked to placental defects [12–14].
T23041 186-190 JJ denotes Much
T23042 204-206 VBZ denotes is
T23043 191-193 IN denotes of
T23044 194-197 DT denotes the
T23045 198-203 NN denotes death
T23046 207-209 DT denotes an
T23047 219-230 NN denotes consequence
T23048 210-218 JJ denotes indirect
T23049 231-233 IN denotes of
T23050 234-242 JJ denotes probable
T23051 243-250 NN denotes hypoxia
T23052 251-257 VBN denotes linked
T23053 258-260 IN denotes to
T23054 261-270 JJ denotes placental
T23055 271-278 NNS denotes defects
T23056 279-280 -LRB- denotes [
T23057 280-282 CD denotes 12
T23058 282-283 SYM denotes –
T23059 283-285 CD denotes 14
T23060 285-286 -RRB- denotes ]
T23061 286-287 . denotes .
T23062 287-501 sentence denotes However, targeted KO and chimeric studies reveal that Rb autonomously promotes cell cycle exit in newborn neurons, and is required for survival of a subset of neurons, particularly in the retina [2,3,13,14,56–59].
T23063 288-295 RB denotes However
T23064 330-336 VBP denotes reveal
T23065 295-297 , denotes ,
T23066 297-305 VBN denotes targeted
T23067 306-308 NN denotes KO
T23068 322-329 NNS denotes studies
T23069 309-312 CC denotes and
T23070 313-321 JJ denotes chimeric
T23071 337-341 IN denotes that
T23072 358-366 VBZ denotes promotes
T23073 342-344 NN denotes Rb
T23074 345-357 RB denotes autonomously
T23075 367-371 NN denotes cell
T23076 372-377 NN denotes cycle
T23077 378-382 NN denotes exit
T23078 383-385 IN denotes in
T23079 386-393 JJ denotes newborn
T23080 394-401 NNS denotes neurons
T23081 401-403 , denotes ,
T23082 403-406 CC denotes and
T23083 407-409 VBZ denotes is
T23084 410-418 VBN denotes required
T23085 419-422 IN denotes for
T23086 423-431 NN denotes survival
T23087 432-434 IN denotes of
T23088 435-436 DT denotes a
T23089 437-443 NN denotes subset
T23090 444-446 IN denotes of
T23091 447-454 NNS denotes neurons
T23092 454-456 , denotes ,
T23093 456-468 RB denotes particularly
T23094 469-471 IN denotes in
T23095 472-475 DT denotes the
T23096 476-482 NN denotes retina
T23097 483-484 -LRB- denotes [
T23098 484-485 CD denotes 2
T23099 485-486 , denotes ,
T23100 486-487 CD denotes 3
T23101 487-488 , denotes ,
T23102 488-490 CD denotes 13
T23103 490-491 , denotes ,
T23104 491-493 CD denotes 14
T23105 493-494 , denotes ,
T23106 494-496 CD denotes 56
T23107 496-497 SYM denotes –
T23108 497-499 CD denotes 59
T23109 499-500 -RRB- denotes ]
T23110 500-501 . denotes .
T23111 501-627 sentence denotes However, whether Rb also regulates differentiation is obscured by potentially indirect effects of ectopic division and death.
T23112 502-509 RB denotes However
T23113 556-564 VBN denotes obscured
T23114 509-511 , denotes ,
T23115 511-518 IN denotes whether
T23116 527-536 VBZ denotes regulates
T23117 519-521 NN denotes Rb
T23118 522-526 RB denotes also
T23119 537-552 NN denotes differentiation
T23120 553-555 VBZ denotes is
T23121 565-567 IN denotes by
T23122 568-579 RB denotes potentially
T23123 580-588 JJ denotes indirect
T23124 589-596 NNS denotes effects
T23125 597-599 IN denotes of
T23126 600-607 JJ denotes ectopic
T23127 608-616 NN denotes division
T23128 617-620 CC denotes and
T23129 621-626 NN denotes death
T23130 626-627 . denotes .
T23131 627-723 sentence denotes Moreover, a mechanism though which Rb may regulate neuronal maturation has not been elucidated.
T23132 628-636 RB denotes Moreover
T23133 712-722 VBN denotes elucidated
T23134 636-638 , denotes ,
T23135 638-639 DT denotes a
T23136 640-649 NN denotes mechanism
T23137 650-656 IN denotes though
T23138 670-678 VB denotes regulate
T23139 657-662 WDT denotes which
T23140 663-665 NN denotes Rb
T23141 666-669 MD denotes may
T23142 679-687 JJ denotes neuronal
T23143 688-698 NN denotes maturation
T23144 699-702 VBZ denotes has
T23145 703-706 RB denotes not
T23146 707-711 VBN denotes been
T23147 722-723 . denotes .
T23148 723-812 sentence denotes Here, deleting E2f1 specifically rescued ectopic division and death in the Rb KO retina.
T23149 724-728 RB denotes Here
T23150 757-764 VBD denotes rescued
T23151 728-730 , denotes ,
T23152 730-738 VBG denotes deleting
T23153 739-743 NN denotes E2f1
T23154 744-756 RB denotes specifically
T23155 765-772 JJ denotes ectopic
T23156 773-781 NN denotes division
T23157 782-785 CC denotes and
T23158 786-791 NN denotes death
T23159 792-794 IN denotes in
T23160 795-798 DT denotes the
T23161 805-811 NN denotes retina
T23162 799-801 NN denotes Rb
T23163 802-804 NN denotes KO
T23164 811-812 . denotes .
T23165 812-1026 sentence denotes Importantly, major Rb/E2f1 DKO neurons differentiated normally, and ERGs revealed the rescue of rod- and cone-mediated function, implicating a regular signal flow from photoreceptors to bipolar and amacrine cells.
T23166 813-824 RB denotes Importantly
T23167 852-866 VBD denotes differentiated
T23168 824-826 , denotes ,
T23169 826-831 JJ denotes major
T23170 844-851 NNS denotes neurons
T23171 832-834 NN denotes Rb
T23172 835-839 NN denotes E2f1
T23173 834-835 HYPH denotes /
T23174 840-843 NN denotes DKO
T23175 867-875 RB denotes normally
T23176 875-877 , denotes ,
T23177 877-880 CC denotes and
T23178 881-885 NNS denotes ERGs
T23179 886-894 VBD denotes revealed
T23180 895-898 DT denotes the
T23181 899-905 NN denotes rescue
T23182 906-908 IN denotes of
T23183 909-912 NN denotes rod
T23184 923-931 VBN denotes mediated
T23185 912-913 HYPH denotes -
T23186 914-917 CC denotes and
T23187 918-922 NN denotes cone
T23188 922-923 HYPH denotes -
T23189 932-940 NN denotes function
T23190 940-942 , denotes ,
T23191 942-953 VBG denotes implicating
T23192 954-955 DT denotes a
T23193 971-975 NN denotes flow
T23194 956-963 JJ denotes regular
T23195 964-970 NN denotes signal
T23196 976-980 IN denotes from
T23197 981-995 NNS denotes photoreceptors
T23198 996-998 IN denotes to
T23199 999-1006 JJ denotes bipolar
T23200 1020-1025 NNS denotes cells
T23201 1007-1010 CC denotes and
T23202 1011-1019 JJ denotes amacrine
T23203 1025-1026 . denotes .
T23204 1026-1154 sentence denotes Division and death genes were induced in Rb KO cells, and deleting E2f1, but not E2f2 or E2f3, reversed these molecular events.
T23205 1027-1035 NN denotes Division
T23206 1046-1051 NNS denotes genes
T23207 1036-1039 CC denotes and
T23208 1040-1045 NN denotes death
T23209 1057-1064 VBN denotes induced
T23210 1052-1056 VBD denotes were
T23211 1065-1067 IN denotes in
T23212 1068-1070 NN denotes Rb
T23213 1071-1073 NN denotes KO
T23214 1074-1079 NNS denotes cells
T23215 1079-1081 , denotes ,
T23216 1081-1084 CC denotes and
T23217 1085-1093 VBG denotes deleting
T23218 1122-1130 VBD denotes reversed
T23219 1094-1098 NN denotes E2f1
T23220 1098-1100 , denotes ,
T23221 1100-1103 CC denotes but
T23222 1104-1107 RB denotes not
T23223 1108-1112 NN denotes E2f2
T23224 1113-1115 CC denotes or
T23225 1116-1120 NN denotes E2f3
T23226 1120-1122 , denotes ,
T23227 1131-1136 DT denotes these
T23228 1147-1153 NNS denotes events
T23229 1137-1146 JJ denotes molecular
T23230 1153-1154 . denotes .
T23231 1154-1369 sentence denotes E2f1 may also regulate differentiation targets, but whether this contributes to defects in retinal cell maturation is impossible to separate from potentially indirect consequences of deregulated division and death.
T23232 1155-1159 NN denotes E2f1
T23233 1169-1177 VB denotes regulate
T23234 1160-1163 MD denotes may
T23235 1164-1168 RB denotes also
T23236 1178-1193 NN denotes differentiation
T23237 1194-1201 NNS denotes targets
T23238 1201-1203 , denotes ,
T23239 1203-1206 CC denotes but
T23240 1207-1214 IN denotes whether
T23241 1220-1231 VBZ denotes contributes
T23242 1215-1219 DT denotes this
T23243 1270-1272 VBZ denotes is
T23244 1232-1234 IN denotes to
T23245 1235-1242 NNS denotes defects
T23246 1243-1245 IN denotes in
T23247 1246-1253 JJ denotes retinal
T23248 1254-1258 NN denotes cell
T23249 1259-1269 NN denotes maturation
T23250 1273-1283 JJ denotes impossible
T23251 1284-1286 TO denotes to
T23252 1287-1295 VB denotes separate
T23253 1296-1300 IN denotes from
T23254 1301-1312 RB denotes potentially
T23255 1313-1321 JJ denotes indirect
T23256 1322-1334 NNS denotes consequences
T23257 1335-1337 IN denotes of
T23258 1338-1349 VBN denotes deregulated
T23259 1350-1358 NN denotes division
T23260 1359-1362 CC denotes and
T23261 1363-1368 NN denotes death
T23262 1368-1369 . denotes .
T23263 1369-1534 sentence denotes In any case, it is clear that in most retinal cells, including photoreceptors [29], transcription factors that promote differentiation function independently of Rb.
T23264 1370-1372 IN denotes In
T23265 1386-1388 VBZ denotes is
T23266 1373-1376 DT denotes any
T23267 1377-1381 NN denotes case
T23268 1381-1383 , denotes ,
T23269 1383-1385 PRP denotes it
T23270 1389-1394 JJ denotes clear
T23271 1395-1399 IN denotes that
T23272 1505-1513 VBZ denotes function
T23273 1400-1402 IN denotes in
T23274 1403-1407 JJS denotes most
T23275 1416-1421 NNS denotes cells
T23276 1408-1415 JJ denotes retinal
T23277 1421-1423 , denotes ,
T23278 1423-1432 VBG denotes including
T23279 1433-1447 NNS denotes photoreceptors
T23280 1448-1449 -LRB- denotes [
T23281 1449-1451 CD denotes 29
T23282 1451-1452 -RRB- denotes ]
T23283 1452-1454 , denotes ,
T23284 1454-1467 NN denotes transcription
T23285 1468-1475 NNS denotes factors
T23286 1476-1480 WDT denotes that
T23287 1481-1488 VBP denotes promote
T23288 1489-1504 NN denotes differentiation
T23289 1514-1527 RB denotes independently
T23290 1528-1530 IN denotes of
T23291 1531-1533 NN denotes Rb
T23292 1533-1534 . denotes .
T23293 1534-1751 sentence denotes We have also found that E2f1 deletion rescues cell-autonomous ectopic division, death, and differentiation defects in sporadic Rb KO clones generated using a Cre retrovirus vector (M. P. and R. B., unpublished data).
T23294 1535-1537 PRP denotes We
T23295 1548-1553 VBN denotes found
T23296 1538-1542 VBP denotes have
T23297 1543-1547 RB denotes also
T23298 1554-1558 IN denotes that
T23299 1573-1580 VBZ denotes rescues
T23300 1559-1563 NN denotes E2f1
T23301 1564-1572 NN denotes deletion
T23302 1581-1585 NN denotes cell
T23303 1586-1596 JJ denotes autonomous
T23304 1585-1586 HYPH denotes -
T23305 1605-1613 NN denotes division
T23306 1597-1604 JJ denotes ectopic
T23307 1613-1615 , denotes ,
T23308 1615-1620 NN denotes death
T23309 1620-1622 , denotes ,
T23310 1622-1625 CC denotes and
T23311 1626-1641 NN denotes differentiation
T23312 1642-1649 NNS denotes defects
T23313 1650-1652 IN denotes in
T23314 1653-1661 JJ denotes sporadic
T23315 1668-1674 NNS denotes clones
T23316 1662-1664 NN denotes Rb
T23317 1665-1667 NN denotes KO
T23318 1675-1684 VBN denotes generated
T23319 1685-1690 VBG denotes using
T23320 1691-1692 DT denotes a
T23321 1708-1714 NN denotes vector
T23322 1693-1696 NN denotes Cre
T23323 1697-1707 NN denotes retrovirus
T23324 1715-1716 -LRB- denotes (
T23325 1716-1718 NNP denotes M.
T23326 1719-1721 NNP denotes P.
T23327 1722-1725 CC denotes and
T23328 1726-1728 NNP denotes R.
T23329 1729-1731 NNP denotes B.
T23330 1731-1733 , denotes ,
T23331 1733-1744 JJ denotes unpublished
T23332 1745-1749 NNS denotes data
T23333 1749-1750 -RRB- denotes )
T23334 1750-1751 . denotes .
T23335 1751-2067 sentence denotes These data are consistent with the observation that E2f1 overexpression in newborn photoreceptors drives ectopic division and apoptosis [60], and add to the growing evidence indicating that E2f1 is the major, and perhaps only, member of the three activating E2fs required to induce apoptosis in Rb KO cells [10,15].
T23336 1752-1757 DT denotes These
T23337 1758-1762 NNS denotes data
T23338 1763-1766 VBP denotes are
T23339 1767-1777 JJ denotes consistent
T23340 1778-1782 IN denotes with
T23341 1783-1786 DT denotes the
T23342 1787-1798 NN denotes observation
T23343 1799-1803 IN denotes that
T23344 1850-1856 VBZ denotes drives
T23345 1804-1808 NN denotes E2f1
T23346 1809-1823 NN denotes overexpression
T23347 1824-1826 IN denotes in
T23348 1827-1834 JJ denotes newborn
T23349 1835-1849 NNS denotes photoreceptors
T23350 1857-1864 JJ denotes ectopic
T23351 1865-1873 NN denotes division
T23352 1874-1877 CC denotes and
T23353 1878-1887 NN denotes apoptosis
T23354 1888-1889 -LRB- denotes [
T23355 1889-1891 CD denotes 60
T23356 1891-1892 -RRB- denotes ]
T23357 1892-1894 , denotes ,
T23358 1894-1897 CC denotes and
T23359 1898-1901 VBP denotes add
T23360 1902-1904 IN denotes to
T23361 1905-1908 DT denotes the
T23362 1917-1925 NN denotes evidence
T23363 1909-1916 VBG denotes growing
T23364 1926-1936 VBG denotes indicating
T23365 1937-1941 IN denotes that
T23366 1947-1949 VBZ denotes is
T23367 1942-1946 NN denotes E2f1
T23368 1950-1953 DT denotes the
T23369 1979-1985 NN denotes member
T23370 1954-1959 JJ denotes major
T23371 1959-1961 , denotes ,
T23372 1961-1964 CC denotes and
T23373 1965-1972 RB denotes perhaps
T23374 1973-1977 JJ denotes only
T23375 1977-1979 , denotes ,
T23376 1986-1988 IN denotes of
T23377 1989-1992 DT denotes the
T23378 2010-2014 NNS denotes E2fs
T23379 1993-1998 CD denotes three
T23380 1999-2009 VBG denotes activating
T23381 2015-2023 VBN denotes required
T23382 2024-2026 TO denotes to
T23383 2027-2033 VB denotes induce
T23384 2034-2043 NN denotes apoptosis
T23385 2044-2046 IN denotes in
T23386 2047-2049 NN denotes Rb
T23387 2050-2052 NN denotes KO
T23388 2053-2058 NNS denotes cells
T23389 2059-2060 -LRB- denotes [
T23390 2063-2065 CD denotes 15
T23391 2060-2062 CD denotes 10
T23392 2062-2063 , denotes ,
T23393 2065-2066 -RRB- denotes ]
T23394 2066-2067 . denotes .
T23395 2067-2263 sentence denotes Thus, deregulated E2f1 activity in the retina, whether resulting from the inactivation of Rb or from overexpression, promotes unscheduled cell division and triggers apoptosis in susceptible RTCs.
T23396 2068-2072 RB denotes Thus
T23397 2185-2193 VBZ denotes promotes
T23398 2072-2074 , denotes ,
T23399 2074-2085 VBN denotes deregulated
T23400 2091-2099 NN denotes activity
T23401 2086-2090 NN denotes E2f1
T23402 2100-2102 IN denotes in
T23403 2103-2106 DT denotes the
T23404 2107-2113 NN denotes retina
T23405 2113-2115 , denotes ,
T23406 2115-2122 IN denotes whether
T23407 2123-2132 VBG denotes resulting
T23408 2133-2137 IN denotes from
T23409 2138-2141 DT denotes the
T23410 2142-2154 NN denotes inactivation
T23411 2155-2157 IN denotes of
T23412 2158-2160 NN denotes Rb
T23413 2161-2163 CC denotes or
T23414 2164-2168 IN denotes from
T23415 2169-2183 NN denotes overexpression
T23416 2183-2185 , denotes ,
T23417 2194-2205 JJ denotes unscheduled
T23418 2211-2219 NN denotes division
T23419 2206-2210 NN denotes cell
T23420 2220-2223 CC denotes and
T23421 2224-2232 VBZ denotes triggers
T23422 2233-2242 NN denotes apoptosis
T23423 2243-2245 IN denotes in
T23424 2246-2257 JJ denotes susceptible
T23425 2258-2262 NNS denotes RTCs
T23426 2262-2263 . denotes .
T23427 2263-2387 sentence denotes E2f1, rather than other E2fs, may be a potential target for novel therapeutics to prevent retinoblastoma in RB1 +/− humans.
T23428 2264-2268 NN denotes E2f1
T23429 2298-2300 VB denotes be
T23430 2268-2270 , denotes ,
T23431 2270-2276 RB denotes rather
T23432 2277-2281 IN denotes than
T23433 2282-2287 JJ denotes other
T23434 2288-2292 NNS denotes E2fs
T23435 2292-2294 , denotes ,
T23436 2294-2297 MD denotes may
T23437 2301-2302 DT denotes a
T23438 2313-2319 NN denotes target
T23439 2303-2312 JJ denotes potential
T23440 2320-2323 IN denotes for
T23441 2324-2329 JJ denotes novel
T23442 2330-2342 NNS denotes therapeutics
T23443 2343-2345 TO denotes to
T23444 2346-2353 VB denotes prevent
T23445 2354-2368 NN denotes retinoblastoma
T23446 2369-2371 IN denotes in
T23447 2372-2375 NN denotes RB1
T23448 2380-2386 NNS denotes humans
T23449 2376-2377 SYM denotes +
T23450 2377-2378 HYPH denotes /
T23451 2378-2379 SYM denotes −
T23452 2386-2387 . denotes .
T23453 2387-2536 sentence denotes Our ERG studies revealed rescue of the Rb KO rod–bipolar system, and almost complete restoration of the cone–bipolar system following E2f1 deletion.
T23454 2388-2391 PRP$ denotes Our
T23455 2396-2403 NNS denotes studies
T23456 2392-2395 NN denotes ERG
T23457 2404-2412 VBD denotes revealed
T23458 2413-2419 NN denotes rescue
T23459 2420-2422 IN denotes of
T23460 2423-2426 DT denotes the
T23461 2445-2451 NN denotes system
T23462 2427-2429 NN denotes Rb
T23463 2430-2432 NN denotes KO
T23464 2433-2436 NN denotes rod
T23465 2437-2444 JJ denotes bipolar
T23466 2436-2437 HYPH denotes –
T23467 2451-2453 , denotes ,
T23468 2453-2456 CC denotes and
T23469 2457-2463 RB denotes almost
T23470 2464-2472 JJ denotes complete
T23471 2473-2484 NN denotes restoration
T23472 2485-2487 IN denotes of
T23473 2488-2491 DT denotes the
T23474 2505-2511 NN denotes system
T23475 2492-2496 NN denotes cone
T23476 2497-2504 JJ denotes bipolar
T23477 2496-2497 HYPH denotes –
T23478 2512-2521 VBG denotes following
T23479 2522-2526 NN denotes E2f1
T23480 2527-2535 NN denotes deletion
T23481 2535-2536 . denotes .
T23482 2536-2638 sentence denotes There was a slightly lower response in the Rb/E2f1 DKO retina relative to the E2f1 KO control retina.
T23483 2537-2542 EX denotes There
T23484 2543-2546 VBD denotes was
T23485 2547-2548 DT denotes a
T23486 2564-2572 NN denotes response
T23487 2549-2557 RB denotes slightly
T23488 2558-2563 JJR denotes lower
T23489 2573-2575 IN denotes in
T23490 2576-2579 DT denotes the
T23491 2592-2598 NN denotes retina
T23492 2580-2582 NN denotes Rb
T23493 2583-2587 NN denotes E2f1
T23494 2582-2583 HYPH denotes /
T23495 2588-2591 NN denotes DKO
T23496 2599-2607 JJ denotes relative
T23497 2608-2610 IN denotes to
T23498 2611-2614 DT denotes the
T23499 2631-2637 NN denotes retina
T23500 2615-2619 NN denotes E2f1
T23501 2620-2622 NN denotes KO
T23502 2623-2630 NN denotes control
T23503 2637-2638 . denotes .
T23504 2638-2868 sentence denotes This difference might reflect a role for Rb in the development of cones, bipolar cells, or other cells that may contribute to the photopic ERG, including potentially SACs, which do have a serious defect in the Rb/E2f1 DKO retina.
T23505 2639-2643 DT denotes This
T23506 2644-2654 NN denotes difference
T23507 2661-2668 VB denotes reflect
T23508 2655-2660 MD denotes might
T23509 2669-2670 DT denotes a
T23510 2671-2675 NN denotes role
T23511 2676-2679 IN denotes for
T23512 2680-2682 NN denotes Rb
T23513 2683-2685 IN denotes in
T23514 2686-2689 DT denotes the
T23515 2690-2701 NN denotes development
T23516 2702-2704 IN denotes of
T23517 2705-2710 NNS denotes cones
T23518 2710-2712 , denotes ,
T23519 2712-2719 JJ denotes bipolar
T23520 2720-2725 NNS denotes cells
T23521 2725-2727 , denotes ,
T23522 2727-2729 CC denotes or
T23523 2730-2735 JJ denotes other
T23524 2736-2741 NNS denotes cells
T23525 2742-2746 WDT denotes that
T23526 2751-2761 VB denotes contribute
T23527 2747-2750 MD denotes may
T23528 2762-2764 IN denotes to
T23529 2765-2768 DT denotes the
T23530 2778-2781 NN denotes ERG
T23531 2769-2777 JJ denotes photopic
T23532 2781-2783 , denotes ,
T23533 2783-2792 VBG denotes including
T23534 2793-2804 RB denotes potentially
T23535 2805-2809 NNS denotes SACs
T23536 2809-2811 , denotes ,
T23537 2811-2816 WDT denotes which
T23538 2820-2824 VB denotes have
T23539 2817-2819 VBP denotes do
T23540 2825-2826 DT denotes a
T23541 2835-2841 NN denotes defect
T23542 2827-2834 JJ denotes serious
T23543 2842-2844 IN denotes in
T23544 2845-2848 DT denotes the
T23545 2861-2867 NN denotes retina
T23546 2849-2851 NN denotes Rb
T23547 2852-2856 NN denotes E2f1
T23548 2851-2852 HYPH denotes /
T23549 2857-2860 NN denotes DKO
T23550 2867-2868 . denotes .
R6616 T23003 T23004 nsubj Rb,Controls
R6617 T23005 T23006 amod Retinal,Cell
R6618 T23006 T23004 dobj Cell,Controls
R6619 T23007 T23006 appos Division,Cell
R6620 T23008 T23007 cc and,Division
R6621 T23009 T23007 conj Death,Division
R6622 T23010 T23004 prep through,Controls
R6623 T23011 T23010 pobj E2f1,through
R6624 T23013 T23014 nsubj Work,showed
R6625 T23015 T23013 prep in,Work
R6626 T23016 T23017 det the,1990s
R6627 T23017 T23015 pobj 1990s,in
R6628 T23018 T23017 amod early,1990s
R6629 T23019 T23020 mark that,triggers
R6630 T23020 T23014 ccomp triggers,showed
R6631 T23021 T23022 compound Rb,loss
R6632 T23022 T23020 nsubj loss,triggers
R6633 T23023 T23020 dobj defects,triggers
R6634 T23024 T23023 prep in,defects
R6635 T23025 T23026 amod neuronal,exit
R6636 T23026 T23024 pobj exit,in
R6637 T23027 T23028 compound cell,cycle
R6638 T23028 T23026 compound cycle,exit
R6639 T23029 T23026 punct ", ",exit
R6640 T23030 T23026 conj survival,exit
R6641 T23031 T23030 punct ", ",survival
R6642 T23032 T23030 cc and,survival
R6643 T23033 T23030 conj differentiation,survival
R6644 T23034 T23035 punct [,26
R6645 T23035 T23020 parataxis 26,triggers
R6646 T23036 T23037 punct –,28
R6647 T23037 T23035 prep 28,26
R6648 T23038 T23035 punct ],26
R6649 T23039 T23014 punct .,showed
R6650 T23041 T23042 nsubj Much,is
R6651 T23043 T23041 prep of,Much
R6652 T23044 T23045 det the,death
R6653 T23045 T23043 pobj death,of
R6654 T23046 T23047 det an,consequence
R6655 T23047 T23042 attr consequence,is
R6656 T23048 T23047 amod indirect,consequence
R6657 T23049 T23047 prep of,consequence
R6658 T23050 T23051 amod probable,hypoxia
R6659 T23051 T23049 pobj hypoxia,of
R6660 T23052 T23051 acl linked,hypoxia
R6661 T23053 T23052 prep to,linked
R6662 T23054 T23055 amod placental,defects
R6663 T23055 T23053 pobj defects,to
R6664 T23056 T23057 punct [,12
R6665 T23057 T23052 parataxis 12,linked
R6666 T23058 T23059 punct –,14
R6667 T23059 T23057 prep 14,12
R6668 T23060 T23057 punct ],12
R6669 T23061 T23042 punct .,is
R6670 T23063 T23064 advmod However,reveal
R6671 T23065 T23064 punct ", ",reveal
R6672 T23066 T23067 amod targeted,KO
R6673 T23067 T23068 nmod KO,studies
R6674 T23068 T23064 nsubj studies,reveal
R6675 T23069 T23067 cc and,KO
R6676 T23070 T23067 conj chimeric,KO
R6677 T23071 T23072 mark that,promotes
R6678 T23072 T23064 ccomp promotes,reveal
R6679 T23073 T23072 nsubj Rb,promotes
R6680 T23074 T23072 advmod autonomously,promotes
R6681 T23075 T23076 compound cell,cycle
R6682 T23076 T23077 compound cycle,exit
R6683 T23077 T23072 dobj exit,promotes
R6684 T23078 T23072 prep in,promotes
R6685 T23079 T23080 amod newborn,neurons
R6686 T23080 T23078 pobj neurons,in
R6687 T23081 T23072 punct ", ",promotes
R6688 T23082 T23072 cc and,promotes
R6689 T23083 T23084 auxpass is,required
R6690 T23084 T23072 conj required,promotes
R6691 T23085 T23084 prep for,required
R6692 T23086 T23085 pobj survival,for
R6693 T23087 T23086 prep of,survival
R6694 T23088 T23089 det a,subset
R6695 T23089 T23087 pobj subset,of
R6696 T23090 T23089 prep of,subset
R6697 T23091 T23090 pobj neurons,of
R6698 T23092 T23084 punct ", ",required
R6699 T23093 T23094 advmod particularly,in
R6700 T23094 T23084 prep in,required
R6701 T23095 T23096 det the,retina
R6702 T23096 T23094 pobj retina,in
R6703 T23097 T23098 punct [,2
R6704 T23098 T23064 parataxis 2,reveal
R6705 T23099 T23098 punct ",",2
R6706 T23100 T23098 appos 3,2
R6707 T23101 T23098 punct ",",2
R6708 T23102 T23098 appos 13,2
R6709 T23103 T23098 punct ",",2
R6710 T23104 T23098 appos 14,2
R6711 T23105 T23098 punct ",",2
R6712 T23106 T23098 appos 56,2
R6713 T23107 T23108 punct –,59
R6714 T23108 T23106 prep 59,56
R6715 T23109 T23098 punct ],2
R6716 T23110 T23064 punct .,reveal
R6717 T23112 T23113 advmod However,obscured
R6718 T23114 T23113 punct ", ",obscured
R6719 T23115 T23116 mark whether,regulates
R6720 T23116 T23113 csubjpass regulates,obscured
R6721 T23117 T23116 nsubj Rb,regulates
R6722 T23118 T23116 advmod also,regulates
R6723 T23119 T23116 dobj differentiation,regulates
R6724 T23120 T23113 auxpass is,obscured
R6725 T23121 T23113 agent by,obscured
R6726 T23122 T23123 advmod potentially,indirect
R6727 T23123 T23124 amod indirect,effects
R6728 T23124 T23121 pobj effects,by
R6729 T23125 T23124 prep of,effects
R6730 T23126 T23127 amod ectopic,division
R6731 T23127 T23125 pobj division,of
R6732 T23128 T23127 cc and,division
R6733 T23129 T23127 conj death,division
R6734 T23130 T23113 punct .,obscured
R6735 T23132 T23133 advmod Moreover,elucidated
R6736 T23134 T23133 punct ", ",elucidated
R6737 T23135 T23136 det a,mechanism
R6738 T23136 T23133 nsubjpass mechanism,elucidated
R6739 T23137 T23138 prep though,regulate
R6740 T23138 T23136 relcl regulate,mechanism
R6741 T23139 T23137 pobj which,though
R6742 T23140 T23138 nsubj Rb,regulate
R6743 T23141 T23138 aux may,regulate
R6744 T23142 T23143 amod neuronal,maturation
R6745 T23143 T23138 dobj maturation,regulate
R6746 T23144 T23133 aux has,elucidated
R6747 T23145 T23133 neg not,elucidated
R6748 T23146 T23133 auxpass been,elucidated
R6749 T23147 T23133 punct .,elucidated
R6750 T23149 T23150 advmod Here,rescued
R6751 T23151 T23150 punct ", ",rescued
R6752 T23152 T23150 csubj deleting,rescued
R6753 T23153 T23152 dobj E2f1,deleting
R6754 T23154 T23150 advmod specifically,rescued
R6755 T23155 T23156 amod ectopic,division
R6756 T23156 T23150 dobj division,rescued
R6757 T23157 T23156 cc and,division
R6758 T23158 T23156 conj death,division
R6759 T23159 T23150 prep in,rescued
R6760 T23160 T23161 det the,retina
R6761 T23161 T23159 pobj retina,in
R6762 T23162 T23163 compound Rb,KO
R6763 T23163 T23161 compound KO,retina
R6764 T23164 T23150 punct .,rescued
R6765 T23166 T23167 advmod Importantly,differentiated
R6766 T23168 T23167 punct ", ",differentiated
R6767 T23169 T23170 amod major,neurons
R6768 T23170 T23167 nsubj neurons,differentiated
R6769 T23171 T23172 compound Rb,E2f1
R6770 T23172 T23174 compound E2f1,DKO
R6771 T23173 T23172 punct /,E2f1
R6772 T23174 T23170 compound DKO,neurons
R6773 T23175 T23167 advmod normally,differentiated
R6774 T23176 T23167 punct ", ",differentiated
R6775 T23177 T23167 cc and,differentiated
R6776 T23178 T23179 nsubj ERGs,revealed
R6777 T23179 T23167 conj revealed,differentiated
R6778 T23180 T23181 det the,rescue
R6779 T23181 T23179 dobj rescue,revealed
R6780 T23182 T23181 prep of,rescue
R6781 T23183 T23184 npadvmod rod,mediated
R6782 T23184 T23189 amod mediated,function
R6783 T23185 T23183 punct -,rod
R6784 T23186 T23183 cc and,rod
R6785 T23187 T23183 conj cone,rod
R6786 T23188 T23184 punct -,mediated
R6787 T23189 T23182 pobj function,of
R6788 T23190 T23179 punct ", ",revealed
R6789 T23191 T23179 advcl implicating,revealed
R6790 T23192 T23193 det a,flow
R6791 T23193 T23191 dobj flow,implicating
R6792 T23194 T23193 amod regular,flow
R6793 T23195 T23193 compound signal,flow
R6794 T23196 T23193 prep from,flow
R6795 T23197 T23196 pobj photoreceptors,from
R6796 T23198 T23193 prep to,flow
R6797 T23199 T23200 amod bipolar,cells
R6798 T23200 T23198 pobj cells,to
R6799 T23201 T23199 cc and,bipolar
R6800 T23202 T23199 conj amacrine,bipolar
R6801 T23203 T23179 punct .,revealed
R6802 T23205 T23206 nmod Division,genes
R6803 T23206 T23209 nsubjpass genes,induced
R6804 T23207 T23205 cc and,Division
R6805 T23208 T23205 conj death,Division
R6806 T23210 T23209 auxpass were,induced
R6807 T23211 T23209 prep in,induced
R6808 T23212 T23213 compound Rb,KO
R6809 T23213 T23214 compound KO,cells
R6810 T23214 T23211 pobj cells,in
R6811 T23215 T23209 punct ", ",induced
R6812 T23216 T23209 cc and,induced
R6813 T23217 T23218 csubj deleting,reversed
R6814 T23218 T23209 conj reversed,induced
R6815 T23219 T23217 dobj E2f1,deleting
R6816 T23220 T23219 punct ", ",E2f1
R6817 T23221 T23219 cc but,E2f1
R6818 T23222 T23221 neg not,but
R6819 T23223 T23219 conj E2f2,E2f1
R6820 T23224 T23223 cc or,E2f2
R6821 T23225 T23223 conj E2f3,E2f2
R6822 T23226 T23218 punct ", ",reversed
R6823 T23227 T23228 det these,events
R6824 T23228 T23218 dobj events,reversed
R6825 T23229 T23228 amod molecular,events
R6826 T23230 T23218 punct .,reversed
R6827 T23232 T23233 nsubj E2f1,regulate
R6828 T23234 T23233 aux may,regulate
R6829 T23235 T23233 advmod also,regulate
R6830 T23236 T23237 compound differentiation,targets
R6831 T23237 T23233 dobj targets,regulate
R6832 T23238 T23233 punct ", ",regulate
R6833 T23239 T23233 cc but,regulate
R6834 T23240 T23241 mark whether,contributes
R6835 T23241 T23243 csubj contributes,is
R6836 T23242 T23241 nsubj this,contributes
R6837 T23243 T23233 conj is,regulate
R6838 T23244 T23241 prep to,contributes
R6839 T23245 T23244 pobj defects,to
R6840 T23246 T23245 prep in,defects
R6841 T23247 T23248 amod retinal,cell
R6842 T23248 T23249 compound cell,maturation
R6843 T23249 T23246 pobj maturation,in
R6844 T23250 T23243 acomp impossible,is
R6845 T23251 T23252 aux to,separate
R6846 T23252 T23250 xcomp separate,impossible
R6847 T23253 T23252 prep from,separate
R6848 T23254 T23255 advmod potentially,indirect
R6849 T23255 T23256 amod indirect,consequences
R6850 T23256 T23253 pobj consequences,from
R6851 T23257 T23256 prep of,consequences
R6852 T23258 T23259 amod deregulated,division
R6853 T23259 T23257 pobj division,of
R6854 T23260 T23259 cc and,division
R6855 T23261 T23259 conj death,division
R6856 T23262 T23243 punct .,is
R6857 T23264 T23265 prep In,is
R6858 T23266 T23267 det any,case
R6859 T23267 T23264 pobj case,In
R6860 T23268 T23265 punct ", ",is
R6861 T23269 T23265 nsubj it,is
R6862 T23270 T23265 acomp clear,is
R6863 T23271 T23272 mark that,function
R6864 T23272 T23265 ccomp function,is
R6865 T23273 T23272 prep in,function
R6866 T23274 T23275 amod most,cells
R6867 T23275 T23273 pobj cells,in
R6868 T23276 T23275 amod retinal,cells
R6869 T23277 T23275 punct ", ",cells
R6870 T23278 T23275 prep including,cells
R6871 T23279 T23278 pobj photoreceptors,including
R6872 T23280 T23281 punct [,29
R6873 T23281 T23275 parataxis 29,cells
R6874 T23282 T23281 punct ],29
R6875 T23283 T23272 punct ", ",function
R6876 T23284 T23285 compound transcription,factors
R6877 T23285 T23272 nsubj factors,function
R6878 T23286 T23287 dep that,promote
R6879 T23287 T23285 relcl promote,factors
R6880 T23288 T23287 dobj differentiation,promote
R6881 T23289 T23272 advmod independently,function
R6882 T23290 T23289 prep of,independently
R6883 T23291 T23290 pobj Rb,of
R6884 T23292 T23265 punct .,is
R6885 T23294 T23295 nsubj We,found
R6886 T23296 T23295 aux have,found
R6887 T23297 T23295 advmod also,found
R6888 T23298 T23299 mark that,rescues
R6889 T23299 T23295 ccomp rescues,found
R6890 T23300 T23301 compound E2f1,deletion
R6891 T23301 T23299 nsubj deletion,rescues
R6892 T23302 T23303 npadvmod cell,autonomous
R6893 T23303 T23305 amod autonomous,division
R6894 T23304 T23303 punct -,autonomous
R6895 T23305 T23299 dobj division,rescues
R6896 T23306 T23305 amod ectopic,division
R6897 T23307 T23305 punct ", ",division
R6898 T23308 T23305 conj death,division
R6899 T23309 T23308 punct ", ",death
R6900 T23310 T23308 cc and,death
R6901 T23311 T23312 compound differentiation,defects
R6902 T23312 T23308 conj defects,death
R6903 T23313 T23299 prep in,rescues
R6904 T23314 T23315 amod sporadic,clones
R6905 T23315 T23313 pobj clones,in
R6906 T23316 T23317 compound Rb,KO
R6907 T23317 T23315 compound KO,clones
R6908 T23318 T23315 acl generated,clones
R6909 T23319 T23318 advcl using,generated
R6910 T23320 T23321 det a,vector
R6911 T23321 T23319 dobj vector,using
R6912 T23322 T23323 compound Cre,retrovirus
R6913 T23323 T23321 compound retrovirus,vector
R6914 T23324 T23325 punct (,M.
R6915 T23325 T23319 meta M.,using
R6916 T23326 T23325 nmod P.,M.
R6917 T23327 T23325 cc and,M.
R6918 T23328 T23325 conj R.,M.
R6919 T23329 T23328 nmod B.,R.
R6920 T23330 T23328 punct ", ",R.
R6921 T23331 T23332 amod unpublished,data
R6922 T23332 T23328 conj data,R.
R6923 T23333 T23332 punct ),data
R6924 T23334 T23295 punct .,found
R6925 T23336 T23337 det These,data
R6926 T23337 T23338 nsubj data,are
R6927 T23339 T23338 acomp consistent,are
R6928 T23340 T23339 prep with,consistent
R6929 T23341 T23342 det the,observation
R6930 T23342 T23340 pobj observation,with
R6931 T23343 T23344 mark that,drives
R6932 T23344 T23342 acl drives,observation
R6933 T23345 T23346 compound E2f1,overexpression
R6934 T23346 T23344 nsubj overexpression,drives
R6935 T23347 T23346 prep in,overexpression
R6936 T23348 T23349 amod newborn,photoreceptors
R6937 T23349 T23347 pobj photoreceptors,in
R6938 T23350 T23351 amod ectopic,division
R6939 T23351 T23344 dobj division,drives
R6940 T23352 T23351 cc and,division
R6941 T23353 T23351 conj apoptosis,division
R6942 T23354 T23355 punct [,60
R6943 T23355 T23344 parataxis 60,drives
R6944 T23356 T23355 punct ],60
R6945 T23357 T23338 punct ", ",are
R6946 T23358 T23338 cc and,are
R6947 T23359 T23338 conj add,are
R6948 T23360 T23359 prep to,add
R6949 T23361 T23362 det the,evidence
R6950 T23362 T23360 pobj evidence,to
R6951 T23363 T23362 amod growing,evidence
R6952 T23364 T23362 acl indicating,evidence
R6953 T23365 T23366 mark that,is
R6954 T23366 T23364 ccomp is,indicating
R6955 T23367 T23366 nsubj E2f1,is
R6956 T23368 T23369 det the,member
R6957 T23369 T23366 attr member,is
R6958 T23370 T23369 amod major,member
R6959 T23371 T23370 punct ", ",major
R6960 T23372 T23370 cc and,major
R6961 T23373 T23374 advmod perhaps,only
R6962 T23374 T23370 conj only,major
R6963 T23375 T23369 punct ", ",member
R6964 T23376 T23369 prep of,member
R6965 T23377 T23378 det the,E2fs
R6966 T23378 T23376 pobj E2fs,of
R6967 T23379 T23378 nummod three,E2fs
R6968 T23380 T23378 amod activating,E2fs
R6969 T23381 T23378 acl required,E2fs
R6970 T23382 T23383 aux to,induce
R6971 T23383 T23381 xcomp induce,required
R6972 T23384 T23383 dobj apoptosis,induce
R6973 T23385 T23383 prep in,induce
R6974 T23386 T23387 compound Rb,KO
R6975 T23387 T23388 compound KO,cells
R6976 T23388 T23385 pobj cells,in
R6977 T23389 T23390 punct [,15
R6978 T23390 T23359 parataxis 15,add
R6979 T23391 T23390 nummod 10,15
R6980 T23392 T23390 punct ",",15
R6981 T23393 T23390 punct ],15
R6982 T23394 T23338 punct .,are
R6983 T23396 T23397 advmod Thus,promotes
R6984 T23398 T23397 punct ", ",promotes
R6985 T23399 T23400 amod deregulated,activity
R6986 T23400 T23397 nsubj activity,promotes
R6987 T23401 T23400 compound E2f1,activity
R6988 T23402 T23400 prep in,activity
R6989 T23403 T23404 det the,retina
R6990 T23404 T23402 pobj retina,in
R6991 T23405 T23397 punct ", ",promotes
R6992 T23406 T23407 mark whether,resulting
R6993 T23407 T23397 advcl resulting,promotes
R6994 T23408 T23407 prep from,resulting
R6995 T23409 T23410 det the,inactivation
R6996 T23410 T23408 pobj inactivation,from
R6997 T23411 T23410 prep of,inactivation
R6998 T23412 T23411 pobj Rb,of
R6999 T23413 T23408 cc or,from
R7000 T23414 T23408 conj from,from
R7001 T23415 T23414 pobj overexpression,from
R7002 T23416 T23397 punct ", ",promotes
R7003 T23417 T23418 amod unscheduled,division
R7004 T23418 T23397 dobj division,promotes
R7005 T23419 T23418 compound cell,division
R7006 T23420 T23397 cc and,promotes
R7007 T23421 T23397 conj triggers,promotes
R7008 T23422 T23421 dobj apoptosis,triggers
R7009 T23423 T23421 prep in,triggers
R7010 T23424 T23425 amod susceptible,RTCs
R7011 T23425 T23423 pobj RTCs,in
R7012 T23426 T23397 punct .,promotes
R7013 T23428 T23429 nsubj E2f1,be
R7014 T23430 T23428 punct ", ",E2f1
R7015 T23431 T23432 advmod rather,than
R7016 T23432 T23428 cc than,E2f1
R7017 T23433 T23434 amod other,E2fs
R7018 T23434 T23428 conj E2fs,E2f1
R7019 T23435 T23429 punct ", ",be
R7020 T23436 T23429 aux may,be
R7021 T23437 T23438 det a,target
R7022 T23438 T23429 attr target,be
R7023 T23439 T23438 amod potential,target
R7024 T23440 T23438 prep for,target
R7025 T23441 T23442 amod novel,therapeutics
R7026 T23442 T23440 pobj therapeutics,for
R7027 T23443 T23444 aux to,prevent
R7028 T23444 T23442 advcl prevent,therapeutics
R7029 T23445 T23444 dobj retinoblastoma,prevent
R7030 T23446 T23444 prep in,prevent
R7031 T23447 T23448 nmod RB1,humans
R7032 T23448 T23446 pobj humans,in
R7033 T23449 T23447 punct +,RB1
R7034 T23450 T23447 punct /,RB1
R7035 T23451 T23447 punct −,RB1
R7036 T23452 T23429 punct .,be
R7037 T23454 T23455 poss Our,studies
R7038 T23455 T23457 nsubj studies,revealed
R7039 T23456 T23455 compound ERG,studies
R7040 T23458 T23457 dobj rescue,revealed
R7041 T23459 T23458 prep of,rescue
R7042 T23460 T23461 det the,system
R7043 T23461 T23459 pobj system,of
R7044 T23462 T23463 nmod Rb,KO
R7045 T23463 T23461 nmod KO,system
R7046 T23464 T23465 npadvmod rod,bipolar
R7047 T23465 T23461 amod bipolar,system
R7048 T23466 T23465 punct –,bipolar
R7049 T23467 T23458 punct ", ",rescue
R7050 T23468 T23458 cc and,rescue
R7051 T23469 T23470 advmod almost,complete
R7052 T23470 T23471 amod complete,restoration
R7053 T23471 T23458 conj restoration,rescue
R7054 T23472 T23471 prep of,restoration
R7055 T23473 T23474 det the,system
R7056 T23474 T23472 pobj system,of
R7057 T23475 T23476 npadvmod cone,bipolar
R7058 T23476 T23474 amod bipolar,system
R7059 T23477 T23476 punct –,bipolar
R7060 T23478 T23458 prep following,rescue
R7061 T23479 T23480 compound E2f1,deletion
R7062 T23480 T23478 pobj deletion,following
R7063 T23481 T23457 punct .,revealed
R7064 T23483 T23484 expl There,was
R7065 T23485 T23486 det a,response
R7066 T23486 T23484 attr response,was
R7067 T23487 T23488 advmod slightly,lower
R7068 T23488 T23486 amod lower,response
R7069 T23489 T23486 prep in,response
R7070 T23490 T23491 det the,retina
R7071 T23491 T23489 pobj retina,in
R7072 T23492 T23493 compound Rb,E2f1
R7073 T23493 T23495 compound E2f1,DKO
R7074 T23494 T23493 punct /,E2f1
R7075 T23495 T23491 compound DKO,retina
R7076 T23496 T23484 advcl relative,was
R7077 T23497 T23496 prep to,relative
R7078 T23498 T23499 det the,retina
R7079 T23499 T23497 pobj retina,to
R7080 T23500 T23501 compound E2f1,KO
R7081 T23501 T23499 compound KO,retina
R7082 T23502 T23499 compound control,retina
R7083 T23503 T23484 punct .,was
R7084 T23505 T23506 det This,difference
R7085 T23506 T23507 nsubj difference,reflect
R7086 T23508 T23507 aux might,reflect
R7087 T23509 T23510 det a,role
R7088 T23510 T23507 dobj role,reflect
R7089 T23511 T23510 prep for,role
R7090 T23512 T23511 pobj Rb,for
R7091 T23513 T23510 prep in,role
R7092 T23514 T23515 det the,development
R7093 T23515 T23513 pobj development,in
R7094 T23516 T23515 prep of,development
R7095 T23517 T23516 pobj cones,of
R7096 T23518 T23517 punct ", ",cones
R7097 T23519 T23520 amod bipolar,cells
R7098 T23520 T23517 conj cells,cones
R7099 T23521 T23520 punct ", ",cells
R7100 T23522 T23520 cc or,cells
R7101 T23523 T23524 amod other,cells
R7102 T23524 T23520 conj cells,cells
R7103 T23525 T23526 dep that,contribute
R7104 T23526 T23524 relcl contribute,cells
R7105 T23527 T23526 aux may,contribute
R7106 T23528 T23526 prep to,contribute
R7107 T23529 T23530 det the,ERG
R7108 T23530 T23528 pobj ERG,to
R7109 T23531 T23530 amod photopic,ERG
R7110 T23532 T23524 punct ", ",cells
R7111 T23533 T23524 prep including,cells
R7112 T23534 T23535 advmod potentially,SACs
R7113 T23535 T23533 pobj SACs,including
R7114 T23536 T23535 punct ", ",SACs
R7115 T23537 T23538 dep which,have
R7116 T23538 T23535 relcl have,SACs
R7117 T23539 T23538 aux do,have
R7118 T23540 T23541 det a,defect
R7119 T23541 T23538 dobj defect,have
R7120 T23542 T23541 amod serious,defect
R7121 T23543 T23541 prep in,defect
R7122 T23544 T23545 det the,retina
R7123 T23545 T23543 pobj retina,in
R7124 T23546 T23547 compound Rb,E2f1
R7125 T23547 T23549 compound E2f1,DKO
R7126 T23548 T23547 punct /,E2f1
R7127 T23549 T23545 compound DKO,retina
R7128 T23550 T23507 punct .,reflect

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T22868 0-2 PR_EXT:000013773 denotes Rb
T22869 3-11 GO:0065007 denotes Controls
T22870 12-19 UBERON:0000966 denotes Retinal
T22871 12-24 CL:0009004 denotes Retinal Cell
T22872 20-24 CL_GO_EXT:cell denotes Cell
T22873 20-33 GO:0051301 denotes Cell Division
T22874 20-24 _FRAGMENT denotes Cell
T22875 38-43 GO:0008219 denotes Death
T22876 52-56 PR_EXT:000006852 denotes E2f1
T22877 93-95 PR_EXT:000013773 denotes Rb
T22878 121-129 CL:0000540 denotes neuronal
T22879 130-134 CL_GO_EXT:cell denotes cell
T22880 130-140 GO:0007049 denotes cell cycle
T22881 161-176 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T22882 198-203 GO:0016265 denotes death
T22883 261-270 UBERON:0001987 denotes placental
T22884 342-344 PR_EXT:000013773 denotes Rb
T22885 367-371 CL_GO_EXT:cell denotes cell
T22886 367-377 GO:0007049 denotes cell cycle
T22887 394-401 CL:0000540 denotes neurons
T22888 447-454 CL:0000540 denotes neurons
T22889 476-482 UBERON:0000966 denotes retina
T22890 519-521 PR_EXT:000013773 denotes Rb
T22891 527-536 GO:0065007 denotes regulates
T22892 537-552 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T22893 621-626 GO:0016265 denotes death
T22894 663-665 PR_EXT:000013773 denotes Rb
T22895 670-678 GO:0065007 denotes regulate
T22896 679-687 CL:0000540 denotes neuronal
T22897 679-698 GO:0042551 denotes neuronal maturation
T22898 730-738 SO_EXT:sequence_deletion_process denotes deleting
T22899 739-743 PR_EXT:000006852 denotes E2f1
T22900 757-764 SO_EXT:sequence_rescue_process denotes rescued
T22901 786-791 GO:0016265 denotes death
T22902 799-801 PR_EXT:000013773 denotes Rb
T22903 805-811 UBERON:0000966 denotes retina
T22904 832-834 PR_EXT:000013773 denotes Rb
T22905 835-839 PR_EXT:000006852 denotes E2f1
T22906 844-851 CL:0000540 denotes neurons
T22907 852-866 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T22908 899-905 SO_EXT:sequence_rescue_process denotes rescue
T22909 909-912 CL:0000604 denotes rod
T22910 918-922 CL:0000573 denotes cone
T22911 964-975 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signal flow
T22912 981-995 CL:0000210 denotes photoreceptors
T22913 999-1006 _FRAGMENT denotes bipolar
T22914 1020-1025 CL:0000103 denotes cells
T22915 1011-1025 CL:0000561 denotes amacrine cells
T22916 1020-1025 CL_GO_EXT:cell denotes cells
T22917 1040-1045 GO:0016265 denotes death
T22918 1046-1051 SO_EXT:0000704 denotes genes
T22919 1068-1070 PR_EXT:000013773 denotes Rb
T22920 1074-1079 CL_GO_EXT:cell denotes cells
T22921 1085-1093 SO_EXT:sequence_deletion_process denotes deleting
T22922 1094-1098 PR_EXT:000006852 denotes E2f1
T22923 1108-1112 PR_EXT:000006853 denotes E2f2
T22924 1116-1120 PR_EXT:000006854 denotes E2f3
T22925 1137-1146 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T22926 1155-1159 PR_EXT:000006852 denotes E2f1
T22927 1169-1177 GO:0065007 denotes regulate
T22928 1178-1193 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T22929 1246-1253 UBERON:0000966 denotes retinal
T22930 1246-1258 CL:0009004 denotes retinal cell
T22931 1254-1258 CL_GO_EXT:cell denotes cell
T22932 1254-1269 GO:0048469 denotes cell maturation
T22933 1340-1349 GO:0065007 denotes regulated
T22934 1363-1368 GO:0016265 denotes death
T22935 1408-1415 UBERON:0000966 denotes retinal
T22936 1408-1421 CL:0009004 denotes retinal cells
T22937 1416-1421 CL_GO_EXT:cell denotes cells
T22938 1433-1447 CL:0000210 denotes photoreceptors
T22939 1454-1467 GO_EXT:transcription denotes transcription
T22940 1454-1475 GO_EXT:transcription_factor denotes transcription factors
T22941 1489-1504 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T22942 1531-1533 PR_EXT:000013773 denotes Rb
T22943 1559-1563 PR_EXT:000006852 denotes E2f1
T22944 1564-1572 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T22945 1573-1580 SO_EXT:sequence_rescue_process denotes rescues
T22946 1581-1585 CL_GO_EXT:cell denotes cell
T22947 1615-1620 GO:0016265 denotes death
T22948 1626-1641 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T22949 1662-1664 PR_EXT:000013773 denotes Rb
T22950 1668-1674 SO_EXT:sequence_cloned_entity denotes clones
T22951 1697-1707 NCBITaxon:11632 denotes retrovirus
T22952 1708-1714 SO_EXT:0000440 denotes vector
T22953 1804-1808 PR_EXT:000006852 denotes E2f1
T22954 1813-1823 GO:0010467 denotes expression
T22955 1835-1849 CL:0000210 denotes photoreceptors
T22956 1878-1887 GO:0006915 denotes apoptosis
T22957 1942-1946 PR_EXT:000006852 denotes E2f1
T22958 2010-2014 PR_EXT:E2F denotes E2fs
T22959 2034-2043 GO:0006915 denotes apoptosis
T22960 2047-2049 PR_EXT:000013773 denotes Rb
T22961 2053-2058 CL_GO_EXT:cell denotes cells
T22962 2076-2085 GO:0065007 denotes regulated
T22963 2086-2090 PR_EXT:000006852 denotes E2f1
T22964 2107-2113 UBERON:0000966 denotes retina
T22965 2158-2160 PR_EXT:000013773 denotes Rb
T22966 2173-2183 GO:0010467 denotes expression
T22967 2206-2210 CL_GO_EXT:cell denotes cell
T22968 2206-2219 GO:0051301 denotes cell division
T22969 2233-2242 GO:0006915 denotes apoptosis
T22970 2264-2268 PR_EXT:000006852 denotes E2f1
T22971 2288-2292 PR_EXT:E2F denotes E2fs
T22972 2372-2375 PR_EXT:000013773 denotes RB1
T22973 2376-2377 SO_EXT:normal_or_wild_type_or_present denotes +
T22974 2378-2379 SO_EXT:sequence_nullness_or_absence denotes −
T22975 2380-2386 NCBITaxon:9606 denotes humans
T22976 2413-2419 SO_EXT:sequence_rescue_process denotes rescue
T22977 2427-2429 PR_EXT:000013773 denotes Rb
T22978 2433-2436 CL:0000604 denotes rod
T22979 2437-2444 CL:0000103 denotes bipolar
T22980 2492-2496 CL:0000573 denotes cone
T22981 2497-2504 CL:0000103 denotes bipolar
T22982 2522-2526 PR_EXT:000006852 denotes E2f1
T22983 2527-2535 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T22984 2564-2572 GO_EXT:reaction_or_response denotes response
T22985 2580-2582 PR_EXT:000013773 denotes Rb
T22986 2583-2587 PR_EXT:000006852 denotes E2f1
T22987 2592-2598 UBERON:0000966 denotes retina
T22988 2615-2619 PR_EXT:000006852 denotes E2f1
T22989 2631-2637 UBERON:0000966 denotes retina
T22990 2680-2682 PR_EXT:000013773 denotes Rb
T22991 2690-2710 GO:0046549 denotes development of cones
T22992 2690-2704 _FRAGMENT denotes development of
T22993 2720-2725 GO:0048468 denotes cells
T22994 2736-2741 GO:0048468 denotes cells
T22995 2705-2710 CL:0000573 denotes cones
T22996 2712-2725 CL:0000103 denotes bipolar cells
T22997 2720-2725 CL_GO_EXT:cell denotes cells
T22998 2736-2741 CL_GO_EXT:cell denotes cells
T22999 2769-2777 GO:0036367 denotes photopic
T23000 2849-2851 PR_EXT:000013773 denotes Rb
T23001 2852-2856 PR_EXT:000006852 denotes E2f1
T23002 2861-2867 UBERON:0000966 denotes retina
R6612 T22875 T22874 _lexicallyChainedTo Death,Cell
R6613 T22914 T22913 _lexicallyChainedTo cells,bipolar
R6614 T22993 T22992 _lexicallyChainedTo cells,development of
R6615 T22994 T22992 _lexicallyChainedTo cells,development of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T22813 1155-1159 PR:000006852 denotes E2f1
T22814 1169-1177 GO:0065007 denotes regulate
T22815 1246-1253 UBERON:0000966 denotes retinal
T22816 1246-1258 CL:0009004 denotes retinal cell
T22817 1254-1269 GO:0048469 denotes cell maturation
T22818 1340-1349 GO:0065007 denotes regulated
T22819 1363-1368 GO:0016265 denotes death
T22820 1408-1415 UBERON:0000966 denotes retinal
T22769 0-2 PR:000013773 denotes Rb
T22770 3-11 GO:0065007 denotes Controls
T22771 12-19 UBERON:0000966 denotes Retinal
T22772 12-24 CL:0009004 denotes Retinal Cell
T22773 20-33 GO:0051301 denotes Cell Division
T22774 20-24 _FRAGMENT denotes Cell
T22775 38-43 GO:0008219 denotes Death
T22776 52-56 PR:000006852 denotes E2f1
T22777 93-95 PR:000013773 denotes Rb
T22778 121-129 CL:0000540 denotes neuronal
T22779 130-140 GO:0007049 denotes cell cycle
T22780 198-203 GO:0016265 denotes death
T22781 261-270 UBERON:0001987 denotes placental
T22782 342-344 PR:000013773 denotes Rb
T22783 367-377 GO:0007049 denotes cell cycle
T22784 394-401 CL:0000540 denotes neurons
T22785 447-454 CL:0000540 denotes neurons
T22786 476-482 UBERON:0000966 denotes retina
T22787 519-521 PR:000013773 denotes Rb
T22788 527-536 GO:0065007 denotes regulates
T22789 621-626 GO:0016265 denotes death
T22790 663-665 PR:000013773 denotes Rb
T22791 670-678 GO:0065007 denotes regulate
T22792 679-687 CL:0000540 denotes neuronal
T22793 679-698 GO:0042551 denotes neuronal maturation
T22794 739-743 PR:000006852 denotes E2f1
T22795 786-791 GO:0016265 denotes death
T22796 799-801 PR:000013773 denotes Rb
T22797 805-811 UBERON:0000966 denotes retina
T22798 832-834 PR:000013773 denotes Rb
T22799 835-839 PR:000006852 denotes E2f1
T22800 844-851 CL:0000540 denotes neurons
T22801 909-912 CL:0000604 denotes rod
T22802 918-922 CL:0000573 denotes cone
T22803 981-995 CL:0000210 denotes photoreceptors
T22804 999-1006 _FRAGMENT denotes bipolar
T22805 1020-1025 CL:0000103 denotes cells
T22806 1011-1025 CL:0000561 denotes amacrine cells
T22807 1040-1045 GO:0016265 denotes death
T22808 1046-1051 SO:0000704 denotes genes
T22809 1068-1070 PR:000013773 denotes Rb
T22810 1094-1098 PR:000006852 denotes E2f1
T22811 1108-1112 PR:000006853 denotes E2f2
T22812 1116-1120 PR:000006854 denotes E2f3
T22821 1408-1421 CL:0009004 denotes retinal cells
T22822 1433-1447 CL:0000210 denotes photoreceptors
T22823 1531-1533 PR:000013773 denotes Rb
T22824 1559-1563 PR:000006852 denotes E2f1
T22825 1615-1620 GO:0016265 denotes death
T22826 1662-1664 PR:000013773 denotes Rb
T22827 1697-1707 NCBITaxon:11632 denotes retrovirus
T22828 1708-1714 SO:0000440 denotes vector
T22829 1804-1808 PR:000006852 denotes E2f1
T22830 1813-1823 GO:0010467 denotes expression
T22831 1835-1849 CL:0000210 denotes photoreceptors
T22832 1878-1887 GO:0006915 denotes apoptosis
T22833 1942-1946 PR:000006852 denotes E2f1
T22834 2034-2043 GO:0006915 denotes apoptosis
T22835 2047-2049 PR:000013773 denotes Rb
T22836 2076-2085 GO:0065007 denotes regulated
T22837 2086-2090 PR:000006852 denotes E2f1
T22838 2107-2113 UBERON:0000966 denotes retina
T22839 2158-2160 PR:000013773 denotes Rb
T22840 2173-2183 GO:0010467 denotes expression
T22841 2206-2219 GO:0051301 denotes cell division
T22842 2233-2242 GO:0006915 denotes apoptosis
T22843 2264-2268 PR:000006852 denotes E2f1
T22844 2372-2375 PR:000013773 denotes RB1
T22845 2380-2386 NCBITaxon:9606 denotes humans
T22846 2427-2429 PR:000013773 denotes Rb
T22847 2433-2436 CL:0000604 denotes rod
T22848 2437-2444 CL:0000103 denotes bipolar
T22849 2492-2496 CL:0000573 denotes cone
T22850 2497-2504 CL:0000103 denotes bipolar
T22851 2522-2526 PR:000006852 denotes E2f1
T22852 2580-2582 PR:000013773 denotes Rb
T22853 2583-2587 PR:000006852 denotes E2f1
T22854 2592-2598 UBERON:0000966 denotes retina
T22855 2615-2619 PR:000006852 denotes E2f1
T22856 2631-2637 UBERON:0000966 denotes retina
T22857 2680-2682 PR:000013773 denotes Rb
T22858 2690-2710 GO:0046549 denotes development of cones
T22859 2690-2704 _FRAGMENT denotes development of
T22860 2720-2725 GO:0048468 denotes cells
T22861 2736-2741 GO:0048468 denotes cells
T22862 2705-2710 CL:0000573 denotes cones
T22863 2712-2725 CL:0000103 denotes bipolar cells
T22864 2769-2777 GO:0036367 denotes photopic
T22865 2849-2851 PR:000013773 denotes Rb
T22866 2852-2856 PR:000006852 denotes E2f1
T22867 2861-2867 UBERON:0000966 denotes retina
R6611 T22861 T22859 _lexicallyChainedTo cells,development of
R6608 T22775 T22774 _lexicallyChainedTo Death,Cell
R6609 T22805 T22804 _lexicallyChainedTo cells,bipolar
R6610 T22860 T22859 _lexicallyChainedTo cells,development of

2_test

Id Subject Object Predicate Lexical cue
17608565-1406933-84869008 178-180 1406933 denotes 26
17608565-1406932-84869008 178-180 1406932 denotes 26
17608565-7958874-84869008 178-180 7958874 denotes 26
17608565-12607001-84869009 280-282 12607001 denotes 12
17608565-12093735-84869009 280-282 12093735 denotes 12
17608565-12529408-84869009 280-282 12529408 denotes 12
17608565-15193257-84869010 484-485 15193257 denotes 2
17608565-15231717-84869011 486-487 15231717 denotes 3
17608565-12093735-84869012 488-490 12093735 denotes 13
17608565-12529408-84869013 491-493 12529408 denotes 14
17608565-7925271-84869014 494-496 7925271 denotes 56
17608565-9620848-84869014 494-496 9620848 denotes 56
17608565-9508781-84869014 494-496 9508781 denotes 56
17608565-11435948-84869014 494-496 11435948 denotes 56
17608565-14991054-84869015 1449-1451 14991054 denotes 29
17608565-11704831-84869016 1889-1891 11704831 denotes 60
17608565-9207076-84869017 2060-2062 9207076 denotes 10
17608565-15976820-84869018 2063-2065 15976820 denotes 15
T50692 178-180 1406933 denotes 26
T8827 178-180 1406932 denotes 26
T66937 178-180 7958874 denotes 26
T49577 280-282 12607001 denotes 12
T76010 280-282 12093735 denotes 12
T58357 280-282 12529408 denotes 12
T97555 484-485 15193257 denotes 2
T34975 486-487 15231717 denotes 3
T7298 488-490 12093735 denotes 13
T34038 491-493 12529408 denotes 14
T64450 494-496 7925271 denotes 56
T10775 494-496 9620848 denotes 56
T80701 494-496 9508781 denotes 56
T43950 494-496 11435948 denotes 56
T75521 1449-1451 14991054 denotes 29
T68435 1889-1891 11704831 denotes 60
T81560 2060-2062 9207076 denotes 10
T56207 2063-2065 15976820 denotes 15