PMC:1914394 / 43095-54071 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T23464	2445-2448	NN	denotes	rod
T23465	2449-2456	JJ	denotes	bipolar
T23003	12-14	NN	denotes	Rb
T23004	15-23	VBZ	denotes	Controls
T23005	24-31	JJ	denotes	Retinal
T23006	32-36	NN	denotes	Cell
T23007	37-45	NN	denotes	Division
T23008	46-49	CC	denotes	and
T23009	50-55	NN	denotes	Death
T23010	56-63	IN	denotes	through
T23011	64-68	NN	denotes	E2f1
T23012	68-197	sentence	denotes	Work in the early 1990s showed that Rb loss triggers defects in neuronal cell cycle exit, survival, and differentiation [26–28].
T23013	69-73	NN	denotes	Work
T23014	93-99	VBD	denotes	showed
T23015	74-76	IN	denotes	in
T23016	77-80	DT	denotes	the
T23017	87-92	NNS	denotes	1990s
T23018	81-86	JJ	denotes	early
T23019	100-104	IN	denotes	that
T23020	113-121	VBZ	denotes	triggers
T23021	105-107	NN	denotes	Rb
T23022	108-112	NN	denotes	loss
T23023	122-129	NNS	denotes	defects
T23024	130-132	IN	denotes	in
T23025	133-141	JJ	denotes	neuronal
T23026	153-157	NN	denotes	exit
T23027	142-146	NN	denotes	cell
T23028	147-152	NN	denotes	cycle
T23029	157-159	,	denotes	,
T23030	159-167	NN	denotes	survival
T23031	167-169	,	denotes	,
T23032	169-172	CC	denotes	and
T23033	173-188	NN	denotes	differentiation
T23034	189-190	-LRB-	denotes	[
T23035	190-192	CD	denotes	26
T23036	192-193	SYM	denotes	–
T23037	193-195	CD	denotes	28
T23038	195-196	-RRB-	denotes	]
T23039	196-197	.	denotes	.
T23040	197-299	sentence	denotes	Much of the death is an indirect consequence of probable hypoxia linked to placental defects [12–14].
T23041	198-202	JJ	denotes	Much
T23042	216-218	VBZ	denotes	is
T23043	203-205	IN	denotes	of
T23044	206-209	DT	denotes	the
T23045	210-215	NN	denotes	death
T23046	219-221	DT	denotes	an
T23047	231-242	NN	denotes	consequence
T23048	222-230	JJ	denotes	indirect
T23049	243-245	IN	denotes	of
T23050	246-254	JJ	denotes	probable
T23051	255-262	NN	denotes	hypoxia
T23052	263-269	VBN	denotes	linked
T23053	270-272	IN	denotes	to
T23054	273-282	JJ	denotes	placental
T23055	283-290	NNS	denotes	defects
T23056	291-292	-LRB-	denotes	[
T23057	292-294	CD	denotes	12
T23058	294-295	SYM	denotes	–
T23059	295-297	CD	denotes	14
T23060	297-298	-RRB-	denotes	]
T23061	298-299	.	denotes	.
T23062	299-513	sentence	denotes	However, targeted KO and chimeric studies reveal that Rb autonomously promotes cell cycle exit in newborn neurons, and is required for survival of a subset of neurons, particularly in the retina [2,3,13,14,56–59].
T23063	300-307	RB	denotes	However
T23064	342-348	VBP	denotes	reveal
T23065	307-309	,	denotes	,
T23066	309-317	VBN	denotes	targeted
T23067	318-320	NN	denotes	KO
T23068	334-341	NNS	denotes	studies
T23069	321-324	CC	denotes	and
T23070	325-333	JJ	denotes	chimeric
T23071	349-353	IN	denotes	that
T23072	370-378	VBZ	denotes	promotes
T23073	354-356	NN	denotes	Rb
T23074	357-369	RB	denotes	autonomously
T23075	379-383	NN	denotes	cell
T23076	384-389	NN	denotes	cycle
T23077	390-394	NN	denotes	exit
T23078	395-397	IN	denotes	in
T23079	398-405	JJ	denotes	newborn
T23080	406-413	NNS	denotes	neurons
T23081	413-415	,	denotes	,
T23082	415-418	CC	denotes	and
T23083	419-421	VBZ	denotes	is
T23084	422-430	VBN	denotes	required
T23085	431-434	IN	denotes	for
T23086	435-443	NN	denotes	survival
T23087	444-446	IN	denotes	of
T23088	447-448	DT	denotes	a
T23089	449-455	NN	denotes	subset
T23090	456-458	IN	denotes	of
T23091	459-466	NNS	denotes	neurons
T23092	466-468	,	denotes	,
T23093	468-480	RB	denotes	particularly
T23094	481-483	IN	denotes	in
T23095	484-487	DT	denotes	the
T23096	488-494	NN	denotes	retina
T23097	495-496	-LRB-	denotes	[
T23098	496-497	CD	denotes	2
T23099	497-498	,	denotes	,
T23100	498-499	CD	denotes	3
T23101	499-500	,	denotes	,
T23102	500-502	CD	denotes	13
T23103	502-503	,	denotes	,
T23104	503-505	CD	denotes	14
T23105	505-506	,	denotes	,
T23106	506-508	CD	denotes	56
T23107	508-509	SYM	denotes	–
T23108	509-511	CD	denotes	59
T23109	511-512	-RRB-	denotes	]
T23110	512-513	.	denotes	.
T23111	513-639	sentence	denotes	However, whether Rb also regulates differentiation is obscured by potentially indirect effects of ectopic division and death.
T23112	514-521	RB	denotes	However
T23113	568-576	VBN	denotes	obscured
T23114	521-523	,	denotes	,
T23115	523-530	IN	denotes	whether
T23116	539-548	VBZ	denotes	regulates
T23117	531-533	NN	denotes	Rb
T23118	534-538	RB	denotes	also
T23119	549-564	NN	denotes	differentiation
T23120	565-567	VBZ	denotes	is
T23121	577-579	IN	denotes	by
T23122	580-591	RB	denotes	potentially
T23123	592-600	JJ	denotes	indirect
T23124	601-608	NNS	denotes	effects
T23125	609-611	IN	denotes	of
T23126	612-619	JJ	denotes	ectopic
T23127	620-628	NN	denotes	division
T23128	629-632	CC	denotes	and
T23129	633-638	NN	denotes	death
T23130	638-639	.	denotes	.
T23131	639-735	sentence	denotes	Moreover, a mechanism though which Rb may regulate neuronal maturation has not been elucidated.
T23132	640-648	RB	denotes	Moreover
T23133	724-734	VBN	denotes	elucidated
T23134	648-650	,	denotes	,
T23135	650-651	DT	denotes	a
T23136	652-661	NN	denotes	mechanism
T23137	662-668	IN	denotes	though
T23138	682-690	VB	denotes	regulate
T23139	669-674	WDT	denotes	which
T23140	675-677	NN	denotes	Rb
T23141	678-681	MD	denotes	may
T23142	691-699	JJ	denotes	neuronal
T23143	700-710	NN	denotes	maturation
T23144	711-714	VBZ	denotes	has
T23145	715-718	RB	denotes	not
T23146	719-723	VBN	denotes	been
T23147	734-735	.	denotes	.
T23148	735-824	sentence	denotes	Here, deleting E2f1 specifically rescued ectopic division and death in the Rb KO retina.
T23149	736-740	RB	denotes	Here
T23150	769-776	VBD	denotes	rescued
T23151	740-742	,	denotes	,
T23152	742-750	VBG	denotes	deleting
T23153	751-755	NN	denotes	E2f1
T23154	756-768	RB	denotes	specifically
T23155	777-784	JJ	denotes	ectopic
T23156	785-793	NN	denotes	division
T23157	794-797	CC	denotes	and
T23158	798-803	NN	denotes	death
T23159	804-806	IN	denotes	in
T23160	807-810	DT	denotes	the
T23161	817-823	NN	denotes	retina
T23162	811-813	NN	denotes	Rb
T23163	814-816	NN	denotes	KO
T23164	823-824	.	denotes	.
T23165	824-1038	sentence	denotes	Importantly, major Rb/E2f1 DKO neurons differentiated normally, and ERGs revealed the rescue of rod- and cone-mediated function, implicating a regular signal flow from photoreceptors to bipolar and amacrine cells.
T23166	825-836	RB	denotes	Importantly
T23167	864-878	VBD	denotes	differentiated
T23168	836-838	,	denotes	,
T23169	838-843	JJ	denotes	major
T23170	856-863	NNS	denotes	neurons
T23171	844-846	NN	denotes	Rb
T23172	847-851	NN	denotes	E2f1
T23173	846-847	HYPH	denotes	/
T23174	852-855	NN	denotes	DKO
T23175	879-887	RB	denotes	normally
T23176	887-889	,	denotes	,
T23177	889-892	CC	denotes	and
T23178	893-897	NNS	denotes	ERGs
T23179	898-906	VBD	denotes	revealed
T23180	907-910	DT	denotes	the
T23181	911-917	NN	denotes	rescue
T23182	918-920	IN	denotes	of
T23183	921-924	NN	denotes	rod
T23184	935-943	VBN	denotes	mediated
T23185	924-925	HYPH	denotes	-
T23186	926-929	CC	denotes	and
T23187	930-934	NN	denotes	cone
T23188	934-935	HYPH	denotes	-
T23189	944-952	NN	denotes	function
T23190	952-954	,	denotes	,
T23191	954-965	VBG	denotes	implicating
T23192	966-967	DT	denotes	a
T23193	983-987	NN	denotes	flow
T23194	968-975	JJ	denotes	regular
T23195	976-982	NN	denotes	signal
T23196	988-992	IN	denotes	from
T23197	993-1007	NNS	denotes	photoreceptors
T23198	1008-1010	IN	denotes	to
T23199	1011-1018	JJ	denotes	bipolar
T23200	1032-1037	NNS	denotes	cells
T23201	1019-1022	CC	denotes	and
T23202	1023-1031	JJ	denotes	amacrine
T23203	1037-1038	.	denotes	.
T23204	1038-1166	sentence	denotes	Division and death genes were induced in Rb KO cells, and deleting E2f1, but not E2f2 or E2f3, reversed these molecular events.
T23205	1039-1047	NN	denotes	Division
T23206	1058-1063	NNS	denotes	genes
T23207	1048-1051	CC	denotes	and
T23208	1052-1057	NN	denotes	death
T23209	1069-1076	VBN	denotes	induced
T23210	1064-1068	VBD	denotes	were
T23211	1077-1079	IN	denotes	in
T23212	1080-1082	NN	denotes	Rb
T23213	1083-1085	NN	denotes	KO
T23214	1086-1091	NNS	denotes	cells
T23215	1091-1093	,	denotes	,
T23216	1093-1096	CC	denotes	and
T23217	1097-1105	VBG	denotes	deleting
T23218	1134-1142	VBD	denotes	reversed
T23219	1106-1110	NN	denotes	E2f1
T23220	1110-1112	,	denotes	,
T23221	1112-1115	CC	denotes	but
T23222	1116-1119	RB	denotes	not
T23223	1120-1124	NN	denotes	E2f2
T23224	1125-1127	CC	denotes	or
T23225	1128-1132	NN	denotes	E2f3
T23226	1132-1134	,	denotes	,
T23227	1143-1148	DT	denotes	these
T23228	1159-1165	NNS	denotes	events
T23229	1149-1158	JJ	denotes	molecular
T23230	1165-1166	.	denotes	.
T23231	1166-1381	sentence	denotes	E2f1 may also regulate differentiation targets, but whether this contributes to defects in retinal cell maturation is impossible to separate from potentially indirect consequences of deregulated division and death.
T23232	1167-1171	NN	denotes	E2f1
T23233	1181-1189	VB	denotes	regulate
T23234	1172-1175	MD	denotes	may
T23235	1176-1180	RB	denotes	also
T23236	1190-1205	NN	denotes	differentiation
T23237	1206-1213	NNS	denotes	targets
T23238	1213-1215	,	denotes	,
T23239	1215-1218	CC	denotes	but
T23240	1219-1226	IN	denotes	whether
T23241	1232-1243	VBZ	denotes	contributes
T23242	1227-1231	DT	denotes	this
T23243	1282-1284	VBZ	denotes	is
T23244	1244-1246	IN	denotes	to
T23245	1247-1254	NNS	denotes	defects
T23246	1255-1257	IN	denotes	in
T23247	1258-1265	JJ	denotes	retinal
T23248	1266-1270	NN	denotes	cell
T23249	1271-1281	NN	denotes	maturation
T23250	1285-1295	JJ	denotes	impossible
T23251	1296-1298	TO	denotes	to
T23252	1299-1307	VB	denotes	separate
T23253	1308-1312	IN	denotes	from
T23254	1313-1324	RB	denotes	potentially
T23255	1325-1333	JJ	denotes	indirect
T23256	1334-1346	NNS	denotes	consequences
T23257	1347-1349	IN	denotes	of
T23258	1350-1361	VBN	denotes	deregulated
T23259	1362-1370	NN	denotes	division
T23260	1371-1374	CC	denotes	and
T23261	1375-1380	NN	denotes	death
T23262	1380-1381	.	denotes	.
T23263	1381-1546	sentence	denotes	In any case, it is clear that in most retinal cells, including photoreceptors [29], transcription factors that promote differentiation function independently of Rb.
T23264	1382-1384	IN	denotes	In
T23265	1398-1400	VBZ	denotes	is
T23266	1385-1388	DT	denotes	any
T23267	1389-1393	NN	denotes	case
T23268	1393-1395	,	denotes	,
T23269	1395-1397	PRP	denotes	it
T23270	1401-1406	JJ	denotes	clear
T23271	1407-1411	IN	denotes	that
T23272	1517-1525	VBZ	denotes	function
T23273	1412-1414	IN	denotes	in
T23274	1415-1419	JJS	denotes	most
T23275	1428-1433	NNS	denotes	cells
T23276	1420-1427	JJ	denotes	retinal
T23277	1433-1435	,	denotes	,
T23278	1435-1444	VBG	denotes	including
T23279	1445-1459	NNS	denotes	photoreceptors
T23280	1460-1461	-LRB-	denotes	[
T23281	1461-1463	CD	denotes	29
T23282	1463-1464	-RRB-	denotes	]
T23283	1464-1466	,	denotes	,
T23284	1466-1479	NN	denotes	transcription
T23285	1480-1487	NNS	denotes	factors
T23286	1488-1492	WDT	denotes	that
T23287	1493-1500	VBP	denotes	promote
T23288	1501-1516	NN	denotes	differentiation
T23289	1526-1539	RB	denotes	independently
T23290	1540-1542	IN	denotes	of
T23291	1543-1545	NN	denotes	Rb
T23292	1545-1546	.	denotes	.
T23293	1546-1763	sentence	denotes	We have also found that E2f1 deletion rescues cell-autonomous ectopic division, death, and differentiation defects in sporadic Rb KO clones generated using a Cre retrovirus vector (M. P. and R. B., unpublished data).
T23294	1547-1549	PRP	denotes	We
T23295	1560-1565	VBN	denotes	found
T23296	1550-1554	VBP	denotes	have
T23297	1555-1559	RB	denotes	also
T23298	1566-1570	IN	denotes	that
T23299	1585-1592	VBZ	denotes	rescues
T23300	1571-1575	NN	denotes	E2f1
T23301	1576-1584	NN	denotes	deletion
T23302	1593-1597	NN	denotes	cell
T23303	1598-1608	JJ	denotes	autonomous
T23304	1597-1598	HYPH	denotes	-
T23305	1617-1625	NN	denotes	division
T23306	1609-1616	JJ	denotes	ectopic
T23307	1625-1627	,	denotes	,
T23308	1627-1632	NN	denotes	death
T23309	1632-1634	,	denotes	,
T23310	1634-1637	CC	denotes	and
T23311	1638-1653	NN	denotes	differentiation
T23312	1654-1661	NNS	denotes	defects
T23313	1662-1664	IN	denotes	in
T23314	1665-1673	JJ	denotes	sporadic
T23315	1680-1686	NNS	denotes	clones
T23316	1674-1676	NN	denotes	Rb
T23317	1677-1679	NN	denotes	KO
T23318	1687-1696	VBN	denotes	generated
T23319	1697-1702	VBG	denotes	using
T23320	1703-1704	DT	denotes	a
T23321	1720-1726	NN	denotes	vector
T23322	1705-1708	NN	denotes	Cre
T23323	1709-1719	NN	denotes	retrovirus
T23324	1727-1728	-LRB-	denotes	(
T23325	1728-1730	NNP	denotes	M.
T23326	1731-1733	NNP	denotes	P.
T23327	1734-1737	CC	denotes	and
T23328	1738-1740	NNP	denotes	R.
T23329	1741-1743	NNP	denotes	B.
T23330	1743-1745	,	denotes	,
T23331	1745-1756	JJ	denotes	unpublished
T23332	1757-1761	NNS	denotes	data
T23333	1761-1762	-RRB-	denotes	)
T23334	1762-1763	.	denotes	.
T23335	1763-2079	sentence	denotes	These data are consistent with the observation that E2f1 overexpression in newborn photoreceptors drives ectopic division and apoptosis [60], and add to the growing evidence indicating that E2f1 is the major, and perhaps only, member of the three activating E2fs required to induce apoptosis in Rb KO cells [10,15].
T23336	1764-1769	DT	denotes	These
T23337	1770-1774	NNS	denotes	data
T23338	1775-1778	VBP	denotes	are
T23339	1779-1789	JJ	denotes	consistent
T23340	1790-1794	IN	denotes	with
T23341	1795-1798	DT	denotes	the
T23342	1799-1810	NN	denotes	observation
T23343	1811-1815	IN	denotes	that
T23344	1862-1868	VBZ	denotes	drives
T23345	1816-1820	NN	denotes	E2f1
T23346	1821-1835	NN	denotes	overexpression
T23347	1836-1838	IN	denotes	in
T23348	1839-1846	JJ	denotes	newborn
T23349	1847-1861	NNS	denotes	photoreceptors
T23350	1869-1876	JJ	denotes	ectopic
T23351	1877-1885	NN	denotes	division
T23352	1886-1889	CC	denotes	and
T23353	1890-1899	NN	denotes	apoptosis
T23354	1900-1901	-LRB-	denotes	[
T23355	1901-1903	CD	denotes	60
T23356	1903-1904	-RRB-	denotes	]
T23357	1904-1906	,	denotes	,
T23358	1906-1909	CC	denotes	and
T23359	1910-1913	VBP	denotes	add
T23360	1914-1916	IN	denotes	to
T23361	1917-1920	DT	denotes	the
T23362	1929-1937	NN	denotes	evidence
T23363	1921-1928	VBG	denotes	growing
T23364	1938-1948	VBG	denotes	indicating
T23365	1949-1953	IN	denotes	that
T23366	1959-1961	VBZ	denotes	is
T23367	1954-1958	NN	denotes	E2f1
T23368	1962-1965	DT	denotes	the
T23369	1991-1997	NN	denotes	member
T23370	1966-1971	JJ	denotes	major
T23371	1971-1973	,	denotes	,
T23372	1973-1976	CC	denotes	and
T23373	1977-1984	RB	denotes	perhaps
T23374	1985-1989	JJ	denotes	only
T23375	1989-1991	,	denotes	,
T23376	1998-2000	IN	denotes	of
T23377	2001-2004	DT	denotes	the
T23378	2022-2026	NNS	denotes	E2fs
T23379	2005-2010	CD	denotes	three
T23380	2011-2021	VBG	denotes	activating
T23381	2027-2035	VBN	denotes	required
T23382	2036-2038	TO	denotes	to
T23383	2039-2045	VB	denotes	induce
T23384	2046-2055	NN	denotes	apoptosis
T23385	2056-2058	IN	denotes	in
T23386	2059-2061	NN	denotes	Rb
T23387	2062-2064	NN	denotes	KO
T23388	2065-2070	NNS	denotes	cells
T23389	2071-2072	-LRB-	denotes	[
T23390	2075-2077	CD	denotes	15
T23391	2072-2074	CD	denotes	10
T23392	2074-2075	,	denotes	,
T23393	2077-2078	-RRB-	denotes	]
T23394	2078-2079	.	denotes	.
T23395	2079-2275	sentence	denotes	Thus, deregulated E2f1 activity in the retina, whether resulting from the inactivation of Rb or from overexpression, promotes unscheduled cell division and triggers apoptosis in susceptible RTCs.
T23396	2080-2084	RB	denotes	Thus
T23397	2197-2205	VBZ	denotes	promotes
T23398	2084-2086	,	denotes	,
T23399	2086-2097	VBN	denotes	deregulated
T23400	2103-2111	NN	denotes	activity
T23401	2098-2102	NN	denotes	E2f1
T23402	2112-2114	IN	denotes	in
T23403	2115-2118	DT	denotes	the
T23404	2119-2125	NN	denotes	retina
T23405	2125-2127	,	denotes	,
T23406	2127-2134	IN	denotes	whether
T23407	2135-2144	VBG	denotes	resulting
T23408	2145-2149	IN	denotes	from
T23409	2150-2153	DT	denotes	the
T23410	2154-2166	NN	denotes	inactivation
T23411	2167-2169	IN	denotes	of
T23412	2170-2172	NN	denotes	Rb
T23413	2173-2175	CC	denotes	or
T23414	2176-2180	IN	denotes	from
T23415	2181-2195	NN	denotes	overexpression
T23416	2195-2197	,	denotes	,
T23417	2206-2217	JJ	denotes	unscheduled
T23418	2223-2231	NN	denotes	division
T23419	2218-2222	NN	denotes	cell
T23420	2232-2235	CC	denotes	and
T23421	2236-2244	VBZ	denotes	triggers
T23422	2245-2254	NN	denotes	apoptosis
T23423	2255-2257	IN	denotes	in
T23424	2258-2269	JJ	denotes	susceptible
T23425	2270-2274	NNS	denotes	RTCs
T23426	2274-2275	.	denotes	.
T23427	2275-2399	sentence	denotes	E2f1, rather than other E2fs, may be a potential target for novel therapeutics to prevent retinoblastoma in RB1 +/− humans.
T23428	2276-2280	NN	denotes	E2f1
T23429	2310-2312	VB	denotes	be
T23430	2280-2282	,	denotes	,
T23431	2282-2288	RB	denotes	rather
T23432	2289-2293	IN	denotes	than
T23433	2294-2299	JJ	denotes	other
T23434	2300-2304	NNS	denotes	E2fs
T23435	2304-2306	,	denotes	,
T23436	2306-2309	MD	denotes	may
T23437	2313-2314	DT	denotes	a
T23438	2325-2331	NN	denotes	target
T23439	2315-2324	JJ	denotes	potential
T23440	2332-2335	IN	denotes	for
T23441	2336-2341	JJ	denotes	novel
T23442	2342-2354	NNS	denotes	therapeutics
T23443	2355-2357	TO	denotes	to
T23444	2358-2365	VB	denotes	prevent
T23445	2366-2380	NN	denotes	retinoblastoma
T23446	2381-2383	IN	denotes	in
T23447	2384-2387	NN	denotes	RB1
T23448	2392-2398	NNS	denotes	humans
T23449	2388-2389	SYM	denotes	+
T23450	2389-2390	HYPH	denotes	/
T23451	2390-2391	SYM	denotes	−
T23452	2398-2399	.	denotes	.
T23453	2399-2548	sentence	denotes	Our ERG studies revealed rescue of the Rb KO rod–bipolar system, and almost complete restoration of the cone–bipolar system following E2f1 deletion.
T23454	2400-2403	PRP$	denotes	Our
T23455	2408-2415	NNS	denotes	studies
T23456	2404-2407	NN	denotes	ERG
T23457	2416-2424	VBD	denotes	revealed
T23458	2425-2431	NN	denotes	rescue
T23459	2432-2434	IN	denotes	of
T23460	2435-2438	DT	denotes	the
T23461	2457-2463	NN	denotes	system
T23462	2439-2441	NN	denotes	Rb
T23463	2442-2444	NN	denotes	KO
T23466	2448-2449	HYPH	denotes	–
T23467	2463-2465	,	denotes	,
T23468	2465-2468	CC	denotes	and
T23469	2469-2475	RB	denotes	almost
T23470	2476-2484	JJ	denotes	complete
T23471	2485-2496	NN	denotes	restoration
T23472	2497-2499	IN	denotes	of
T23473	2500-2503	DT	denotes	the
T23474	2517-2523	NN	denotes	system
T23475	2504-2508	NN	denotes	cone
T23476	2509-2516	JJ	denotes	bipolar
T23477	2508-2509	HYPH	denotes	–
T23478	2524-2533	VBG	denotes	following
T23479	2534-2538	NN	denotes	E2f1
T23480	2539-2547	NN	denotes	deletion
T23481	2547-2548	.	denotes	.
T23482	2548-2650	sentence	denotes	There was a slightly lower response in the Rb/E2f1 DKO retina relative to the E2f1 KO control retina.
T23483	2549-2554	EX	denotes	There
T23484	2555-2558	VBD	denotes	was
T23485	2559-2560	DT	denotes	a
T23486	2576-2584	NN	denotes	response
T23487	2561-2569	RB	denotes	slightly
T23488	2570-2575	JJR	denotes	lower
T23489	2585-2587	IN	denotes	in
T23490	2588-2591	DT	denotes	the
T23491	2604-2610	NN	denotes	retina
T23492	2592-2594	NN	denotes	Rb
T23493	2595-2599	NN	denotes	E2f1
T23494	2594-2595	HYPH	denotes	/
T23495	2600-2603	NN	denotes	DKO
T23496	2611-2619	JJ	denotes	relative
T23497	2620-2622	IN	denotes	to
T23498	2623-2626	DT	denotes	the
T23499	2643-2649	NN	denotes	retina
T23500	2627-2631	NN	denotes	E2f1
T23501	2632-2634	NN	denotes	KO
T23502	2635-2642	NN	denotes	control
T23503	2649-2650	.	denotes	.
T23504	2650-2880	sentence	denotes	This difference might reflect a role for Rb in the development of cones, bipolar cells, or other cells that may contribute to the photopic ERG, including potentially SACs, which do have a serious defect in the Rb/E2f1 DKO retina.
T23505	2651-2655	DT	denotes	This
T23506	2656-2666	NN	denotes	difference
T23507	2673-2680	VB	denotes	reflect
T23508	2667-2672	MD	denotes	might
T23509	2681-2682	DT	denotes	a
T23510	2683-2687	NN	denotes	role
T23511	2688-2691	IN	denotes	for
T23512	2692-2694	NN	denotes	Rb
T23513	2695-2697	IN	denotes	in
T23514	2698-2701	DT	denotes	the
T23515	2702-2713	NN	denotes	development
T23516	2714-2716	IN	denotes	of
T23517	2717-2722	NNS	denotes	cones
T23518	2722-2724	,	denotes	,
T23519	2724-2731	JJ	denotes	bipolar
T23520	2732-2737	NNS	denotes	cells
T23521	2737-2739	,	denotes	,
T23522	2739-2741	CC	denotes	or
T23523	2742-2747	JJ	denotes	other
T23524	2748-2753	NNS	denotes	cells
T23525	2754-2758	WDT	denotes	that
T23526	2763-2773	VB	denotes	contribute
T23527	2759-2762	MD	denotes	may
T23528	2774-2776	IN	denotes	to
T23529	2777-2780	DT	denotes	the
T23530	2790-2793	NN	denotes	ERG
T23531	2781-2789	JJ	denotes	photopic
T23532	2793-2795	,	denotes	,
T23533	2795-2804	VBG	denotes	including
T23534	2805-2816	RB	denotes	potentially
T23535	2817-2821	NNS	denotes	SACs
T23536	2821-2823	,	denotes	,
T23537	2823-2828	WDT	denotes	which
T23538	2832-2836	VB	denotes	have
T23539	2829-2831	VBP	denotes	do
T23540	2837-2838	DT	denotes	a
T23541	2847-2853	NN	denotes	defect
T23542	2839-2846	JJ	denotes	serious
T23543	2854-2856	IN	denotes	in
T23544	2857-2860	DT	denotes	the
T23545	2873-2879	NN	denotes	retina
T23546	2861-2863	NN	denotes	Rb
T23547	2864-2868	NN	denotes	E2f1
T23548	2863-2864	HYPH	denotes	/
T23549	2869-2872	NN	denotes	DKO
T23550	2879-2880	.	denotes	.
T24609	2882-2884	NN	denotes	Rb
T24610	2885-2893	VBZ	denotes	Controls
T24611	2894-2897	NN	denotes	SAC
T24612	2898-2913	NN	denotes	Differentiation
T24613	2914-2921	IN	denotes	through
T24614	2922-2927	NN	denotes	E2f3a
T24615	2927-3085	sentence	denotes	Comprehensive marker analysis revealed that, in striking contrast to other retinal neurons, E2f1 deletion did not suppress defects in Rb KO cholinergic SACs.
T24616	2928-2941	JJ	denotes	Comprehensive
T24617	2949-2957	NN	denotes	analysis
T24618	2942-2948	NN	denotes	marker
T24619	2958-2966	VBD	denotes	revealed
T24620	2967-2971	IN	denotes	that
T24621	3042-3050	VB	denotes	suppress
T24622	2971-2973	,	denotes	,
T24623	2973-2975	IN	denotes	in
T24624	2976-2984	JJ	denotes	striking
T24625	2985-2993	NN	denotes	contrast
T24626	2994-2996	IN	denotes	to
T24627	2997-3002	JJ	denotes	other
T24628	3011-3018	NNS	denotes	neurons
T24629	3003-3010	JJ	denotes	retinal
T24630	3018-3020	,	denotes	,
T24631	3020-3024	NN	denotes	E2f1
T24632	3025-3033	NN	denotes	deletion
T24633	3034-3037	VBD	denotes	did
T24634	3038-3041	RB	denotes	not
T24635	3051-3058	NNS	denotes	defects
T24636	3059-3061	IN	denotes	in
T24637	3062-3064	NN	denotes	Rb
T24638	3065-3067	NN	denotes	KO
T24639	3080-3084	NNS	denotes	SACs
T24640	3068-3079	JJ	denotes	cholinergic
T24641	3084-3085	.	denotes	.
T24642	3085-3197	sentence	denotes	Instead, we observed E2f1-independent defects in the synthesis and transport of a large cohort of SAC proteins.
T24643	3086-3093	RB	denotes	Instead
T24644	3098-3106	VBD	denotes	observed
T24645	3093-3095	,	denotes	,
T24646	3095-3097	PRP	denotes	we
T24647	3107-3111	NN	denotes	E2f1
T24648	3112-3123	JJ	denotes	independent
T24649	3111-3112	HYPH	denotes	-
T24650	3124-3131	NNS	denotes	defects
T24651	3132-3134	IN	denotes	in
T24652	3135-3138	DT	denotes	the
T24653	3139-3148	NN	denotes	synthesis
T24654	3149-3152	CC	denotes	and
T24655	3153-3162	NN	denotes	transport
T24656	3163-3165	IN	denotes	of
T24657	3166-3167	DT	denotes	a
T24658	3174-3180	NN	denotes	cohort
T24659	3168-3173	JJ	denotes	large
T24660	3181-3183	IN	denotes	of
T24661	3184-3187	NN	denotes	SAC
T24662	3188-3196	NN	denotes	proteins
T24663	3196-3197	.	denotes	.
T24664	3197-3410	sentence	denotes	These data expand insight into the development of these important interneurons, but more critically, provide to our knowledge the first unambiguous evidence that Rb regulates neurogenesis beyond terminal mitosis.
T24665	3198-3203	DT	denotes	These
T24666	3204-3208	NNS	denotes	data
T24667	3209-3215	VBP	denotes	expand
T24668	3216-3223	NN	denotes	insight
T24669	3224-3228	IN	denotes	into
T24670	3229-3232	DT	denotes	the
T24671	3233-3244	NN	denotes	development
T24672	3245-3247	IN	denotes	of
T24673	3248-3253	DT	denotes	these
T24674	3264-3276	NNS	denotes	interneurons
T24675	3254-3263	JJ	denotes	important
T24676	3276-3278	,	denotes	,
T24677	3278-3281	CC	denotes	but
T24678	3282-3286	RBR	denotes	more
T24679	3287-3297	RB	denotes	critically
T24680	3299-3306	VB	denotes	provide
T24681	3297-3299	,	denotes	,
T24682	3307-3309	IN	denotes	to
T24683	3310-3313	PRP$	denotes	our
T24684	3314-3323	NN	denotes	knowledge
T24685	3324-3327	DT	denotes	the
T24686	3346-3354	NN	denotes	evidence
T24687	3328-3333	JJ	denotes	first
T24688	3334-3345	JJ	denotes	unambiguous
T24689	3355-3359	IN	denotes	that
T24690	3363-3372	VBZ	denotes	regulates
T24691	3360-3362	NN	denotes	Rb
T24692	3373-3385	NN	denotes	neurogenesis
T24693	3386-3392	IN	denotes	beyond
T24694	3393-3401	JJ	denotes	terminal
T24695	3402-3409	NN	denotes	mitosis
T24696	3409-3410	.	denotes	.
T24697	3410-3630	sentence	denotes	Rb binds more than 100 factors [43], and in several non-neuronal cells, such as skeletal muscle, adipocytes, and bone, it binds and potentiates tissue-specific transcription factors that promote differentiation [31–33].
T24698	3411-3413	NN	denotes	Rb
T24699	3414-3419	VBZ	denotes	binds
T24700	3420-3424	JJR	denotes	more
T24701	3430-3433	CD	denotes	100
T24702	3425-3429	IN	denotes	than
T24703	3434-3441	NNS	denotes	factors
T24704	3442-3443	-LRB-	denotes	[
T24705	3443-3445	CD	denotes	43
T24706	3445-3446	-RRB-	denotes	]
T24707	3446-3448	,	denotes	,
T24708	3448-3451	CC	denotes	and
T24709	3452-3454	IN	denotes	in
T24710	3533-3538	VBZ	denotes	binds
T24711	3455-3462	JJ	denotes	several
T24712	3476-3481	NNS	denotes	cells
T24713	3463-3475	JJ	denotes	non-neuronal
T24714	3481-3483	,	denotes	,
T24715	3483-3487	JJ	denotes	such
T24716	3488-3490	IN	denotes	as
T24738	3625-3626	SYM	denotes	–
T24739	3626-3628	CD	denotes	33
T24740	3628-3629	-RRB-	denotes	]
T24741	3629-3630	.	denotes	.
T24742	3630-3803	sentence	denotes	The idea that Rb promotes muscle differentiation by potentiating Myod1 activity was contested [61], and other mechanisms proposed [62,63], but not involving E2f repression.
T24743	3631-3634	DT	denotes	The
T24744	3635-3639	NN	denotes	idea
T24745	3715-3724	VBN	denotes	contested
T24746	3640-3644	IN	denotes	that
T24747	3648-3656	VBZ	denotes	promotes
T24748	3645-3647	NN	denotes	Rb
T24749	3657-3663	NN	denotes	muscle
T24750	3664-3679	NN	denotes	differentiation
T24751	3680-3682	IN	denotes	by
T24752	3683-3695	VBG	denotes	potentiating
T24753	3696-3701	NN	denotes	Myod1
T24754	3702-3710	NN	denotes	activity
T24755	3711-3714	VBD	denotes	was
T24756	3725-3726	-LRB-	denotes	[
T24757	3726-3728	CD	denotes	61
T24758	3728-3729	-RRB-	denotes	]
T24759	3729-3731	,	denotes	,
T24760	3731-3734	CC	denotes	and
T24761	3735-3740	JJ	denotes	other
T24762	3741-3751	NNS	denotes	mechanisms
T24763	3752-3760	VBN	denotes	proposed
T24764	3761-3762	-LRB-	denotes	[
T24765	3765-3767	CD	denotes	63
T24766	3762-3764	CD	denotes	62
T24767	3764-3765	,	denotes	,
T24768	3767-3768	-RRB-	denotes	]
T24769	3768-3770	,	denotes	,
T24770	3770-3773	CC	denotes	but
T24771	3778-3787	VBG	denotes	involving
T24772	3774-3777	RB	denotes	not
T24773	3788-3791	NN	denotes	E2f
T24774	3792-3802	NN	denotes	repression
T24775	3802-3803	.	denotes	.
T24776	3803-3900	sentence	denotes	Strikingly, however, we discovered that Rb promotes SAC differentiation through E2f3 (Figure 8).
T24777	3804-3814	RB	denotes	Strikingly
T24778	3828-3838	VBD	denotes	discovered
T24779	3814-3816	,	denotes	,
T24780	3816-3823	RB	denotes	however
T24781	3823-3825	,	denotes	,
T24782	3825-3827	PRP	denotes	we
T24783	3839-3843	IN	denotes	that
T24784	3847-3855	VBZ	denotes	promotes
T24785	3844-3846	NN	denotes	Rb
T24786	3856-3859	NN	denotes	SAC
T24787	3860-3875	NN	denotes	differentiation
T24788	3876-3883	IN	denotes	through
T24789	3884-3888	NN	denotes	E2f3
T24790	3889-3890	-LRB-	denotes	(
T24791	3890-3896	NN	denotes	Figure
T24792	3897-3898	CD	denotes	8
T24793	3898-3899	-RRB-	denotes	)
T24794	3899-3900	.	denotes	.
T24795	3900-3901	sentence	denotes
T24796	3911-3917	sentence	denotes	Rb Reg
T24797	3911-3913	NN	denotes	Rb
T24798	3914-3916	NNS	denotes	Re
T24799	3916-3917	IN	denotes	g
T24826	4653-4656	PRP$	denotes	its
T24827	4657-4661	NN	denotes	role
T24828	4662-4664	IN	denotes	in
T24829	4665-4676	VBG	denotes	controlling
T24830	4677-4685	NN	denotes	division
T24831	4686-4688	CC	denotes	or
T24832	4689-4694	NN	denotes	death
T24833	4694-4696	:	denotes	:
T24834	4696-4700	NN	denotes	E2f3
T24835	4701-4709	NN	denotes	deletion
T24836	4718-4720	NN	denotes	Rb
T24837	4721-4723	NN	denotes	KO
T24838	4728-4735	NNS	denotes	defects
T24839	4724-4727	NN	denotes	SAC
T24840	4736-4739	CC	denotes	but
T24841	4740-4743	VBD	denotes	did
T24842	4748-4756	VB	denotes	suppress
T24843	4744-4747	RB	denotes	not
T24844	4757-4765	JJ	denotes	aberrant
T24845	4766-4779	NN	denotes	proliferation
T24846	4780-4782	CC	denotes	or
T24847	4783-4788	NN	denotes	death
T24848	4788-4790	,	denotes	,
T24849	4790-4797	IN	denotes	whereas
T24850	4812-4820	VBD	denotes	reversed
T24851	4798-4802	NN	denotes	E2f1
T24852	4803-4811	NN	denotes	deletion
T24853	4821-4829	JJ	denotes	abnormal
T24854	4830-4843	NN	denotes	proliferation
T24855	4844-4847	CC	denotes	and
T24856	4848-4853	NN	denotes	death
T24857	4854-4857	CC	denotes	but
T24858	4858-4861	VBD	denotes	did
T24859	4866-4872	VB	denotes	rescue
T24860	4862-4865	RB	denotes	not
T24861	4873-4876	NN	denotes	SAC
T24862	4877-4892	NN	denotes	differentiation
T24863	4892-4893	.	denotes	.
T24864	4893-4981	sentence	denotes	Double labelling confirmed that E2f1 but not E2f3 deletion reversed Rb KO SAC division.
T24865	4894-4900	JJ	denotes	Double
T24866	4901-4910	NN	denotes	labelling
T24867	4911-4920	VBD	denotes	confirmed
T24868	4921-4925	IN	denotes	that
T24869	4953-4961	VBD	denotes	reversed
T24870	4926-4930	NN	denotes	E2f1
T24871	4944-4952	NN	denotes	deletion
T24872	4931-4934	CC	denotes	but
T24873	4935-4938	RB	denotes	not
T24874	4939-4943	NN	denotes	E2f3
T24875	4962-4964	NN	denotes	Rb
T24876	4965-4967	NN	denotes	KO
T24877	4968-4971	NN	denotes	SAC
T24878	4972-4980	NN	denotes	division
T24879	4980-4981	.	denotes	.
T24880	4981-5107	sentence	denotes	Moreover, deleting E2f1, but not E2f3, reversed deregulated expression of cell cycle and apoptotic genes in the Rb KO retina.
T24881	4982-4990	RB	denotes	Moreover
T24882	5021-5029	VBD	denotes	reversed
T24883	4990-4992	,	denotes	,
T24884	4992-5000	VBG	denotes	deleting
T24885	5001-5005	NN	denotes	E2f1
T24886	5005-5007	,	denotes	,
T24887	5007-5010	CC	denotes	but
T24888	5011-5014	RB	denotes	not
T24889	5015-5019	NN	denotes	E2f3
T24890	5019-5021	,	denotes	,
T24891	5030-5041	VBN	denotes	deregulated
T24892	5042-5052	NN	denotes	expression
T24893	5053-5055	IN	denotes	of
T24894	5056-5060	NN	denotes	cell
T24895	5061-5066	NN	denotes	cycle
T24896	5067-5070	CC	denotes	and
T24897	5071-5080	JJ	denotes	apoptotic
T24898	5081-5086	NNS	denotes	genes
T24899	5087-5089	IN	denotes	in
T24900	5090-5093	DT	denotes	the
T24901	5100-5106	NN	denotes	retina
T24902	5094-5096	NN	denotes	Rb
T24903	5097-5099	NN	denotes	KO
T24904	5106-5107	.	denotes	.
T24905	5107-5248	sentence	denotes	E2f3 is expressed in a subset of CNS neurons (this work) and drives specific cell-cycle–independent defects in Rb KO forebrain neurons [53].
T24906	5108-5112	NN	denotes	E2f3
T24907	5116-5125	VBN	denotes	expressed
T24908	5113-5115	VBZ	denotes	is
T24909	5126-5128	IN	denotes	in
T24910	5129-5130	DT	denotes	a
T24911	5131-5137	NN	denotes	subset
T24912	5138-5140	IN	denotes	of
T24913	5141-5144	NN	denotes	CNS
T24914	5145-5152	NNS	denotes	neurons
T24915	5153-5154	-LRB-	denotes	(
T24916	5159-5163	NN	denotes	work
T24917	5154-5158	DT	denotes	this
T24918	5163-5164	-RRB-	denotes	)
T24919	5165-5168	CC	denotes	and
T24920	5169-5175	VBZ	denotes	drives
T24921	5176-5184	JJ	denotes	specific
T24922	5208-5215	NNS	denotes	defects
T24923	5185-5189	NN	denotes	cell
T24924	5190-5195	NN	denotes	cycle
T24925	5189-5190	HYPH	denotes	-
T24926	5196-5207	JJ	denotes	independent
T24927	5195-5196	HYPH	denotes	–
T24928	5216-5218	IN	denotes	in
T24929	5219-5221	NN	denotes	Rb
T24930	5222-5224	NN	denotes	KO
T24931	5235-5242	NNS	denotes	neurons
T24932	5225-5234	NN	denotes	forebrain
T24933	5243-5244	-LRB-	denotes	[
T24934	5244-5246	CD	denotes	53
T24935	5246-5247	-RRB-	denotes	]
T24936	5247-5248	.	denotes	.
T24937	5248-5378	sentence	denotes	Thus, E2f3 inhibition is the first, and may be the only, mechanism by which Rb participates directly in neuronal differentiation.
T24938	5249-5253	RB	denotes	Thus
T24939	5271-5273	VBZ	denotes	is
T24940	5253-5255	,	denotes	,
T24941	5255-5259	NN	denotes	E2f3
T24942	5260-5270	NN	denotes	inhibition
T24943	5274-5277	DT	denotes	the
T24944	5278-5283	JJ	denotes	first
T24945	5283-5285	,	denotes	,
T24946	5285-5288	CC	denotes	and
T24947	5289-5292	MD	denotes	may
T24948	5293-5295	VB	denotes	be
T24949	5296-5299	DT	denotes	the
T24950	5300-5304	JJ	denotes	only
T24951	5304-5306	,	denotes	,
T24952	5306-5315	NN	denotes	mechanism
T24953	5316-5318	IN	denotes	by
T24954	5328-5340	VBZ	denotes	participates
T24955	5319-5324	WDT	denotes	which
T24956	5325-5327	NN	denotes	Rb
T24957	5341-5349	RB	denotes	directly
T24958	5350-5352	IN	denotes	in
T24959	5353-5361	JJ	denotes	neuronal
T24960	5362-5377	NN	denotes	differentiation
T24961	5377-5378	.	denotes	.
T24962	5378-5505	sentence	denotes	To further dissect the mechanism of action of Rb in SACs we determined the E2f3 isoform it targets to promote differentiation.
T24963	5379-5381	TO	denotes	To
T24964	5390-5397	VB	denotes	dissect
T24965	5382-5389	RB	denotes	further
T24966	5439-5449	VBD	denotes	determined
T24967	5398-5401	DT	denotes	the
T24968	5402-5411	NN	denotes	mechanism
T24969	5412-5414	IN	denotes	of
T24970	5415-5421	NN	denotes	action
T24971	5422-5424	IN	denotes	of
T24972	5425-5427	NN	denotes	Rb
T24973	5428-5430	IN	denotes	in
T24974	5431-5435	NNS	denotes	SACs
T24975	5436-5438	PRP	denotes	we
T24976	5450-5453	DT	denotes	the
T24977	5459-5466	NN	denotes	isoform
T24978	5454-5458	NN	denotes	E2f3
T24979	5467-5469	PRP	denotes	it
T24980	5470-5477	VBZ	denotes	targets
T24981	5478-5480	TO	denotes	to
T24982	5481-5488	VB	denotes	promote
T24983	5489-5504	NN	denotes	differentiation
T24984	5504-5505	.	denotes	.
T24985	5505-5622	sentence	denotes	E2f3b was the primary candidate, since Rb and E2f3b collaborate to repress targets in quiescent cells in vitro [19].
T24986	5506-5511	NN	denotes	E2f3b
T24987	5512-5515	VBD	denotes	was
T24988	5516-5519	DT	denotes	the
T24989	5528-5537	NN	denotes	candidate
T24990	5520-5527	JJ	denotes	primary
T24991	5537-5539	,	denotes	,
T24992	5539-5544	IN	denotes	since
T24993	5558-5569	VBP	denotes	collaborate
T24994	5545-5547	NN	denotes	Rb
T24995	5548-5551	CC	denotes	and
T24996	5552-5557	NN	denotes	E2f3b
T24997	5570-5572	TO	denotes	to
T24998	5573-5580	VB	denotes	repress
T24999	5581-5588	NNS	denotes	targets
T25000	5589-5591	IN	denotes	in
T25001	5592-5601	JJ	denotes	quiescent
T25002	5602-5607	NNS	denotes	cells
T25003	5608-5610	FW	denotes	in
T25004	5611-5616	FW	denotes	vitro
T25005	5617-5618	-LRB-	denotes	[
T25006	5618-5620	CD	denotes	19
T25007	5620-5621	-RRB-	denotes	]
T25008	5621-5622	.	denotes	.
T25009	5622-5825	sentence	denotes	However, in the first work to our knowledge to examine the function of any E2f protein isoform in vivo, we made the surprising observation that Rb regulates SAC differentiation through E2f3a (Figure 8).
T25010	5623-5630	RB	denotes	However
T25011	5730-5734	VBD	denotes	made
T25012	5630-5632	,	denotes	,
T25013	5632-5634	IN	denotes	in
T25014	5635-5638	DT	denotes	the
T25015	5645-5649	NN	denotes	work
T25016	5639-5644	JJ	denotes	first
T25017	5650-5652	IN	denotes	to
T25018	5670-5677	VB	denotes	examine
T25019	5653-5656	PRP$	denotes	our
T25020	5657-5666	NN	denotes	knowledge
T25021	5667-5669	TO	denotes	to
T25022	5678-5681	DT	denotes	the
T25023	5682-5690	NN	denotes	function
T25024	5691-5693	IN	denotes	of
T25025	5694-5697	DT	denotes	any
T25026	5710-5717	NN	denotes	isoform
T25027	5698-5701	NN	denotes	E2f
T25028	5702-5709	NN	denotes	protein
T25029	5718-5720	FW	denotes	in
T25030	5721-5725	FW	denotes	vivo
T25031	5725-5727	,	denotes	,
T25032	5727-5729	PRP	denotes	we
T25033	5735-5738	DT	denotes	the
T25034	5750-5761	NN	denotes	observation
T25035	5739-5749	JJ	denotes	surprising
T25036	5762-5766	IN	denotes	that
T25037	5770-5779	VBZ	denotes	regulates
T25038	5767-5769	NN	denotes	Rb
T25039	5780-5783	NN	denotes	SAC
T25040	5784-5799	NN	denotes	differentiation
T25041	5800-5807	IN	denotes	through
T25042	5808-5813	NN	denotes	E2f3a
T25043	5814-5815	-LRB-	denotes	(
T25044	5815-5821	NN	denotes	Figure
T25045	5822-5823	CD	denotes	8
T25046	5823-5824	-RRB-	denotes	)
T25047	5824-5825	.	denotes	.
T25048	5825-5991	sentence	denotes	Formally, we cannot exclude the possibility that deleting E2f3b might also rescue SAC differentiation, but definitive proof will require analysis of E2f3b null mice.
T25049	5826-5834	RB	denotes	Formally
T25050	5846-5853	VB	denotes	exclude
T25051	5834-5836	,	denotes	,
T25052	5836-5838	PRP	denotes	we
T25053	5839-5842	MD	denotes	can
T25054	5842-5845	RB	denotes	not
T25055	5854-5857	DT	denotes	the
T25056	5858-5869	NN	denotes	possibility
T25057	5870-5874	IN	denotes	that
T25058	5901-5907	VB	denotes	rescue
T25059	5875-5883	VBG	denotes	deleting
T25060	5884-5889	NN	denotes	E2f3b
T25061	5890-5895	MD	denotes	might
T25062	5896-5900	RB	denotes	also
T25063	5908-5911	NN	denotes	SAC
T25064	5912-5927	NN	denotes	differentiation
T25065	5927-5929	,	denotes	,
T25066	5929-5932	CC	denotes	but
T25067	5933-5943	JJ	denotes	definitive
T25068	5944-5949	NN	denotes	proof
T25069	5955-5962	VB	denotes	require
T25070	5950-5954	MD	denotes	will
T25071	5963-5971	NN	denotes	analysis
T25072	5972-5974	IN	denotes	of
T25073	5975-5980	NN	denotes	E2f3b
T25074	5981-5985	JJ	denotes	null
T25075	5986-5990	NNS	denotes	mice
T25076	5990-5991	.	denotes	.
T25077	5991-6106	sentence	denotes	Nevertheless, our data prove that Rb definitely regulates SAC differentiation through the activating E2f3 isoform.
T25078	5992-6004	RB	denotes	Nevertheless
T25079	6015-6020	VBP	denotes	prove
T25080	6004-6006	,	denotes	,
T25081	6006-6009	PRP$	denotes	our
T25082	6010-6014	NNS	denotes	data
T25083	6021-6025	IN	denotes	that
T25084	6040-6049	VBZ	denotes	regulates
T25085	6026-6028	NN	denotes	Rb
T25086	6029-6039	RB	denotes	definitely
T25087	6050-6053	NN	denotes	SAC
T25088	6054-6069	NN	denotes	differentiation
T25089	6070-6077	IN	denotes	through
T25090	6078-6081	DT	denotes	the
T25091	6098-6105	NN	denotes	isoform
T25092	6082-6092	VBG	denotes	activating
T25093	6093-6097	NN	denotes	E2f3
T25094	6105-6106	.	denotes	.
T25716	6108-6116	JJ	denotes	Distinct
T25717	6133-6145	NN	denotes	Localization
T25718	6117-6122	NN	denotes	E2f3a
T25719	6123-6126	CC	denotes	and
T25720	6127-6132	NN	denotes	E2f3b
T25721	6145-6234	sentence	denotes	The subcellular location of E2f isoforms has not to our knowledge been addressed before.
T25722	6146-6149	DT	denotes	The
T25723	6162-6170	NN	denotes	location
T25724	6150-6161	JJ	denotes	subcellular
T25725	6217-6226	VBN	denotes	addressed
T25726	6171-6173	IN	denotes	of
T25727	6174-6177	NN	denotes	E2f
T25728	6178-6186	NNS	denotes	isoforms
T25729	6187-6190	VBZ	denotes	has
T25730	6191-6194	RB	denotes	not
T25731	6195-6197	IN	denotes	to
T25732	6198-6201	PRP$	denotes	our
T25733	6202-6211	NN	denotes	knowledge
T25734	6212-6216	VBN	denotes	been
T25735	6227-6233	RB	denotes	before
T25736	6233-6234	.	denotes	.
T25737	6234-6456	sentence	denotes	E2f3a and E2f3b share 110 C-terminal amino acids that encode the NLS, DNA-binding, marked box, transactivation, and Rb-binding domains [16], yet they exhibit different subcellular distribution in developing retinal cells.
T25738	6235-6240	NN	denotes	E2f3a
T25739	6251-6256	VBP	denotes	share
T25740	6241-6244	CC	denotes	and
T25741	6245-6250	NN	denotes	E2f3b
T25742	6257-6260	CD	denotes	110
T25743	6278-6283	NNS	denotes	acids
T25744	6261-6262	NN	denotes	C
T25745	6263-6271	JJ	denotes	terminal
T25746	6262-6263	HYPH	denotes	-
T25747	6272-6277	NN	denotes	amino
T25748	6284-6288	WDT	denotes	that
T25749	6289-6295	VBP	denotes	encode
T25750	6296-6299	DT	denotes	the
T25751	6362-6369	NNS	denotes	domains
T25752	6300-6303	NN	denotes	NLS
T25753	6303-6305	,	denotes	,
T25754	6305-6308	NN	denotes	DNA
T25755	6308-6309	HYPH	denotes	-
T25756	6309-6316	VBG	denotes	binding
T25757	6316-6318	,	denotes	,
T25758	6318-6324	JJ	denotes	marked
T25759	6325-6328	NN	denotes	box
T25760	6328-6330	,	denotes	,
T25761	6330-6345	NN	denotes	transactivation
T25762	6345-6347	,	denotes	,
T25763	6347-6350	CC	denotes	and
T25764	6351-6353	NN	denotes	Rb
T25765	6353-6354	HYPH	denotes	-
T25766	6354-6361	VBG	denotes	binding
T25767	6370-6371	-LRB-	denotes	[
T25768	6371-6373	CD	denotes	16
T25769	6373-6374	-RRB-	denotes	]
T25770	6374-6376	,	denotes	,
T25771	6376-6379	CC	denotes	yet
T25772	6380-6384	PRP	denotes	they
T25773	6385-6392	VBP	denotes	exhibit
T25774	6393-6402	JJ	denotes	different
T25775	6415-6427	NN	denotes	distribution
T25776	6403-6414	JJ	denotes	subcellular
T25777	6428-6430	IN	denotes	in
T25778	6431-6441	VBG	denotes	developing
T25779	6450-6455	NNS	denotes	cells
T25780	6442-6449	JJ	denotes	retinal
T25781	6455-6456	.	denotes	.
T25782	6456-6524	sentence	denotes	E2f3a is both nuclear and cytoplasmic, but E2f3b is always nuclear.
T25783	6457-6462	NN	denotes	E2f3a
T25784	6463-6465	VBZ	denotes	is
T25785	6466-6470	CC	denotes	both
T25786	6471-6478	JJ	denotes	nuclear
T25787	6479-6482	CC	denotes	and
T25788	6483-6494	JJ	denotes	cytoplasmic
T25789	6494-6496	,	denotes	,
T25790	6496-6499	CC	denotes	but
T25791	6500-6505	NN	denotes	E2f3b
T25792	6506-6508	VBZ	denotes	is
T25793	6509-6515	RB	denotes	always
T25794	6516-6523	JJ	denotes	nuclear
T25795	6523-6524	.	denotes	.
T25796	6524-6632	sentence	denotes	The unique 121- and six-residue N-termini of E2f3a and E2f3b, respectively, likely mediate this difference.
T25797	6525-6528	DT	denotes	The
T25798	6559-6566	NNS	denotes	termini
T25799	6529-6535	JJ	denotes	unique
T25800	6536-6539	CD	denotes	121
T25801	6549-6556	NN	denotes	residue
T25802	6539-6540	HYPH	denotes	-
T25803	6541-6544	CC	denotes	and
T25804	6545-6548	CD	denotes	six
T25805	6548-6549	HYPH	denotes	-
T25806	6557-6558	NNS	denotes	N
T25807	6558-6559	HYPH	denotes	-
T25808	6608-6615	VBP	denotes	mediate
T25809	6567-6569	IN	denotes	of
T25810	6570-6575	NN	denotes	E2f3a
T25811	6576-6579	CC	denotes	and
T25812	6580-6585	NN	denotes	E2f3b
T25813	6585-6587	,	denotes	,
T25814	6587-6599	RB	denotes	respectively
T25815	6599-6601	,	denotes	,
T25816	6601-6607	RB	denotes	likely
T25817	6616-6620	DT	denotes	this
T25818	6621-6631	NN	denotes	difference
T25819	6631-6632	.	denotes	.
T25820	6632-6773	sentence	denotes	This region in E2f1, E2f2, and E2f3a binds Ccna2, establishing a negative regulatory loop that deactivates E2fs in mid-late S-phase [64,65].
T25821	6633-6637	DT	denotes	This
T25822	6638-6644	NN	denotes	region
T25823	6670-6675	VBZ	denotes	binds
T25824	6645-6647	IN	denotes	in
T25825	6648-6652	NN	denotes	E2f1
T25826	6652-6654	,	denotes	,
T25827	6654-6658	NN	denotes	E2f2
T25828	6658-6660	,	denotes	,
T25829	6660-6663	CC	denotes	and
T25830	6664-6669	NN	denotes	E2f3a
T25831	6676-6681	NN	denotes	Ccna2
T25832	6681-6683	,	denotes	,
T25833	6683-6695	VBG	denotes	establishing
T25834	6696-6697	DT	denotes	a
T25835	6718-6722	NN	denotes	loop
T25836	6698-6706	JJ	denotes	negative
T25837	6707-6717	JJ	denotes	regulatory
T25838	6723-6727	WDT	denotes	that
T25839	6728-6739	VBZ	denotes	deactivates
T25840	6740-6744	NNS	denotes	E2fs
T25841	6745-6747	IN	denotes	in
T25842	6748-6751	JJ	denotes	mid
T25843	6752-6756	JJ	denotes	late
T25844	6751-6752	SYM	denotes	-
T25845	6759-6764	NN	denotes	phase
T25846	6757-6758	NN	denotes	S
T25847	6758-6759	HYPH	denotes	-
T25848	6765-6766	-LRB-	denotes	[
T25849	6769-6771	CD	denotes	65
T25850	6766-6768	CD	denotes	64
T25851	6768-6769	,	denotes	,
T25852	6771-6772	-RRB-	denotes	]
T25853	6772-6773	.	denotes	.
T25854	6773-6936	sentence	denotes	However, even E2f3b, which lacks this domain, binds and is regulated by Ccna2 [18], so the domain difference may not explain the unique distributions we observed.
T25855	6774-6781	RB	denotes	However
T25856	6820-6825	VBZ	denotes	binds
T25857	6781-6783	,	denotes	,
T25858	6783-6787	RB	denotes	even
T25859	6788-6793	NN	denotes	E2f3b
T25860	6793-6795	,	denotes	,
T25861	6795-6800	WDT	denotes	which
T25862	6801-6806	VBZ	denotes	lacks
T25863	6807-6811	DT	denotes	this
T25864	6812-6818	NN	denotes	domain
T25865	6818-6820	,	denotes	,
T25866	6826-6829	CC	denotes	and
T25867	6830-6832	VBZ	denotes	is
T25868	6833-6842	VBN	denotes	regulated
T25869	6843-6845	IN	denotes	by
T25870	6846-6851	NN	denotes	Ccna2
T25871	6852-6853	-LRB-	denotes	[
T25872	6853-6855	CD	denotes	18
T25873	6855-6856	-RRB-	denotes	]
T25874	6856-6858	,	denotes	,
T25875	6858-6860	IN	denotes	so
T25876	6891-6898	VB	denotes	explain
T25877	6861-6864	DT	denotes	the
T25878	6872-6882	NN	denotes	difference
T25879	6865-6871	NN	denotes	domain
T25880	6883-6886	MD	denotes	may
T25881	6887-6890	RB	denotes	not
T25882	6899-6902	DT	denotes	the
T25883	6910-6923	NNS	denotes	distributions
T25884	6903-6909	JJ	denotes	unique
T25885	6924-6926	PRP	denotes	we
T25886	6927-6935	VBD	denotes	observed
T25887	6935-6936	.	denotes	.
T25888	6936-7101	sentence	denotes	Rb family and Tfdp proteins can also determine E2f localization [20–22], and we found that a portion of both Rb and Tfdp1 proteins are cytoplasmic in retinal cells.
T25889	6937-6939	NN	denotes	Rb
T25890	6940-6946	NN	denotes	family
T25891	6956-6964	NN	denotes	proteins
T25892	6947-6950	CC	denotes	and
T25893	6951-6955	NN	denotes	Tfdp
T25894	6974-6983	VB	denotes	determine
T25895	6965-6968	MD	denotes	can
T25896	6969-6973	RB	denotes	also
T25897	6984-6987	NN	denotes	E2f
T25898	6988-7000	NN	denotes	localization
T25899	7001-7002	-LRB-	denotes	[
T25900	7002-7004	CD	denotes	20
T25901	7004-7005	SYM	denotes	–
T25902	7005-7007	CD	denotes	22
T25903	7007-7008	-RRB-	denotes	]
T25904	7008-7010	,	denotes	,
T25905	7010-7013	CC	denotes	and
T25906	7014-7016	PRP	denotes	we
T25907	7017-7022	VBD	denotes	found
T25908	7023-7027	IN	denotes	that
T25909	7068-7071	VBP	denotes	are
T25910	7028-7029	DT	denotes	a
T25911	7030-7037	NN	denotes	portion
T25912	7038-7040	IN	denotes	of
T25913	7041-7045	CC	denotes	both
T25914	7046-7048	NN	denotes	Rb
T25915	7059-7067	NN	denotes	proteins
T25916	7049-7052	CC	denotes	and
T25917	7053-7058	NN	denotes	Tfdp1
T25918	7072-7083	JJ	denotes	cytoplasmic
T25919	7084-7086	IN	denotes	in
T25920	7087-7094	JJ	denotes	retinal
T25921	7095-7100	NNS	denotes	cells
T25922	7100-7101	.	denotes	.
T25923	7101-7179	sentence	denotes	Indeed, immunostaining revealed that Rb and E2f3 colocalize to SAC processes.
T25924	7102-7108	RB	denotes	Indeed
T25925	7125-7133	VBD	denotes	revealed
T25926	7108-7110	,	denotes	,
T25927	7110-7124	NN	denotes	immunostaining
T25928	7134-7138	IN	denotes	that
T25929	7151-7161	VBP	denotes	colocalize
T25930	7139-7141	NN	denotes	Rb
T25931	7142-7145	CC	denotes	and
T25932	7146-7150	NN	denotes	E2f3
T25933	7162-7164	IN	denotes	to
T25934	7165-7168	NN	denotes	SAC
T25935	7169-7178	NNS	denotes	processes
T25936	7178-7179	.	denotes	.
T25937	7179-7382	sentence	denotes	The nuclear localization of E2f3b contrasts with that of other repressive E2fs in differentiating muscle, where E2f5 switches from the nucleus to cytoplasm, while E2f4 remains in both compartments [23].
T25938	7180-7183	DT	denotes	The
T25939	7192-7204	NN	denotes	localization
T25940	7184-7191	JJ	denotes	nuclear
T25941	7214-7223	VBZ	denotes	contrasts
T25942	7205-7207	IN	denotes	of
T25943	7208-7213	NN	denotes	E2f3b
T25944	7224-7228	IN	denotes	with
T25945	7229-7233	DT	denotes	that
T25946	7234-7236	IN	denotes	of
T25947	7237-7242	JJ	denotes	other
T25948	7254-7258	NNS	denotes	E2fs
T25949	7243-7253	JJ	denotes	repressive
T25950	7259-7261	IN	denotes	in
T25951	7262-7277	VBG	denotes	differentiating
T25952	7278-7284	NN	denotes	muscle
T25953	7284-7286	,	denotes	,
T25954	7286-7291	WRB	denotes	where
T25955	7297-7305	VBZ	denotes	switches
T25956	7292-7296	NN	denotes	E2f5
T25957	7306-7310	IN	denotes	from
T25958	7311-7314	DT	denotes	the
T25959	7315-7322	NN	denotes	nucleus
T25960	7323-7325	IN	denotes	to
T25961	7326-7335	NN	denotes	cytoplasm
T25962	7335-7337	,	denotes	,
T25963	7337-7342	IN	denotes	while
T25964	7348-7355	VBZ	denotes	remains
T25965	7343-7347	NN	denotes	E2f4
T25966	7356-7358	IN	denotes	in
T25967	7359-7363	DT	denotes	both
T25968	7364-7376	NNS	denotes	compartments
T25969	7377-7378	-LRB-	denotes	[
T25970	7378-7380	CD	denotes	23
T25971	7380-7381	-RRB-	denotes	]
T25972	7381-7382	.	denotes	.
T25973	7382-7507	sentence	denotes	The distinct compartmentalization of E2f3a and E2f3b in the retina suggests temporally and functionally distinct activities.
T25974	7383-7386	DT	denotes	The
T25975	7396-7416	NN	denotes	compartmentalization
T25976	7387-7395	JJ	denotes	distinct
T25977	7450-7458	VBZ	denotes	suggests
T25978	7417-7419	IN	denotes	of
T25979	7420-7425	NN	denotes	E2f3a
T25980	7426-7429	CC	denotes	and
T25981	7430-7435	NN	denotes	E2f3b
T25982	7436-7438	IN	denotes	in
T25983	7439-7442	DT	denotes	the
T25984	7443-7449	NN	denotes	retina
T25985	7459-7469	RB	denotes	temporally
T25986	7487-7495	JJ	denotes	distinct
T25987	7470-7473	CC	denotes	and
T25988	7474-7486	RB	denotes	functionally
T25989	7496-7506	NNS	denotes	activities
T25990	7506-7507	.	denotes	.
T25991	7507-7629	sentence	denotes	Rb distribution matches that of E2f3a, consistent with its critical role in supporting SAC differentiation through E2f3a.
T25992	7508-7510	NN	denotes	Rb
T25993	7511-7523	NN	denotes	distribution
T25994	7524-7531	VBZ	denotes	matches
T25995	7532-7536	DT	denotes	that
T25996	7537-7539	IN	denotes	of
T25997	7540-7545	NN	denotes	E2f3a
T25998	7545-7547	,	denotes	,
T25999	7547-7557	JJ	denotes	consistent
T26000	7558-7562	IN	denotes	with
T26001	7563-7566	PRP$	denotes	its
T26002	7576-7580	NN	denotes	role
T26003	7567-7575	JJ	denotes	critical
T26004	7581-7583	IN	denotes	in
T26005	7584-7594	VBG	denotes	supporting
T26006	7595-7598	NN	denotes	SAC
T26007	7599-7614	NN	denotes	differentiation
T26008	7615-7622	IN	denotes	through
T26009	7623-7628	NN	denotes	E2f3a
T26010	7628-7629	.	denotes	.
T26609	7631-7638	JJ	denotes	Ectopic
T26610	7639-7647	NN	denotes	Division
T26611	7648-7651	CC	denotes	and
T26612	7652-7667	NN	denotes	Differentiation
T26613	7667-7850	sentence	denotes	Rb is critical to ensure that many types of terminally differentiating cells leave the cell cycle (e.g., neurons, gut and skin epithelia, muscle, and lens fibres) (reviewed in [66]).
T26614	7668-7670	NN	denotes	Rb
T26615	7671-7673	VBZ	denotes	is
T26616	7674-7682	JJ	denotes	critical
T26617	7683-7685	TO	denotes	to
T26618	7686-7692	VB	denotes	ensure
T26619	7693-7697	IN	denotes	that
T26620	7745-7750	VBP	denotes	leave
T26621	7698-7702	JJ	denotes	many
T26622	7703-7708	NNS	denotes	types
T26623	7709-7711	IN	denotes	of
T26624	7712-7722	RB	denotes	terminally
T26625	7723-7738	VBG	denotes	differentiating
T26626	7739-7744	NNS	denotes	cells
T26627	7751-7754	DT	denotes	the
T26628	7760-7765	NN	denotes	cycle
T26629	7755-7759	NN	denotes	cell
T26630	7766-7767	-LRB-	denotes	(
T26631	7767-7771	FW	denotes	e.g.
T26632	7773-7780	NNS	denotes	neurons
T26633	7771-7773	,	denotes	,
T26634	7780-7782	,	denotes	,
T26635	7782-7785	NN	denotes	gut
T26636	7795-7804	NNS	denotes	epithelia
T26637	7786-7789	CC	denotes	and
T26638	7790-7794	NN	denotes	skin
T26639	7804-7806	,	denotes	,
T26640	7806-7812	NN	denotes	muscle
T26641	7812-7814	,	denotes	,
T26642	7814-7817	CC	denotes	and
T26643	7818-7822	NN	denotes	lens
T26644	7823-7829	NNS	denotes	fibres
T26645	7829-7830	-RRB-	denotes	)
T26646	7831-7832	-LRB-	denotes	(
T26647	7832-7840	VBN	denotes	reviewed
T26648	7841-7843	IN	denotes	in
T26649	7844-7845	-LRB-	denotes	[
T26650	7845-7847	CD	denotes	66
T26651	7847-7848	-RRB-	denotes	]
T26652	7848-7849	-RRB-	denotes	)
T26653	7849-7850	.	denotes	.
T26654	7850-8052	sentence	denotes	Early overexpression studies in vitro suggested Rb might temper expansion of cycling cells, but KO studies in vivo indicate that its major role is to block division in terminally differentiating cells.
T26655	7851-7856	JJ	denotes	Early
T26656	7872-7879	NNS	denotes	studies
T26657	7857-7871	NN	denotes	overexpression
T26658	7889-7898	VBN	denotes	suggested
T26659	7880-7882	FW	denotes	in
T26660	7883-7888	FW	denotes	vitro
T26661	7899-7901	NN	denotes	Rb
T26662	7908-7914	VB	denotes	temper
T26663	7902-7907	MD	denotes	might
T26664	7915-7924	NN	denotes	expansion
T26665	7925-7927	IN	denotes	of
T26666	7928-7935	NN	denotes	cycling
T26667	7936-7941	NNS	denotes	cells
T26668	7941-7943	,	denotes	,
T26669	7943-7946	CC	denotes	but
T26670	7947-7949	NN	denotes	KO
T26671	7950-7957	NNS	denotes	studies
T26672	7966-7974	VBP	denotes	indicate
T26673	7958-7960	FW	denotes	in
T26674	7961-7965	FW	denotes	vivo
T26675	7975-7979	IN	denotes	that
T26676	7995-7997	VBZ	denotes	is
T26677	7980-7983	PRP$	denotes	its
T26678	7990-7994	NN	denotes	role
T26679	7984-7989	JJ	denotes	major
T26680	7998-8000	TO	denotes	to
T26681	8001-8006	VB	denotes	block
T26682	8007-8015	NN	denotes	division
T26683	8016-8018	IN	denotes	in
T26684	8019-8029	RB	denotes	terminally
T26685	8030-8045	VBG	denotes	differentiating
T26686	8046-8051	NNS	denotes	cells
T26687	8051-8052	.	denotes	.
T26688	8052-8155	sentence	denotes	In its absence, many (but clearly not all) aspects of differentiation go ahead relatively unperturbed.
T26689	8053-8055	IN	denotes	In
T26690	8123-8125	VBP	denotes	go
T26691	8056-8059	PRP$	denotes	its
T26692	8060-8067	NN	denotes	absence
T26693	8067-8069	,	denotes	,
T26694	8069-8073	JJ	denotes	many
T26695	8074-8075	-LRB-	denotes	(
T26696	8075-8078	CC	denotes	but
T26697	8079-8086	RB	denotes	clearly
T26698	8087-8090	RB	denotes	not
T26699	8091-8094	DT	denotes	all
T26700	8096-8103	NNS	denotes	aspects
T26701	8094-8095	-RRB-	denotes	)
T26702	8104-8106	IN	denotes	of
T26703	8107-8122	NN	denotes	differentiation
T26704	8126-8131	RP	denotes	ahead
T26705	8132-8142	RB	denotes	relatively
T26706	8143-8154	JJ	denotes	unperturbed
T26707	8154-8155	.	denotes	.
T26708	8155-8317	sentence	denotes	In the retina, differentiating transition cells are born in the absence of Rb, migrate to the correct layer, and express appropriate markers ([2] and this work).
T26709	8156-8158	IN	denotes	In
T26710	8208-8212	VBN	denotes	born
T26711	8159-8162	DT	denotes	the
T26712	8163-8169	NN	denotes	retina
T26713	8169-8171	,	denotes	,
T26714	8171-8186	VBG	denotes	differentiating
T26715	8198-8203	NNS	denotes	cells
T26716	8187-8197	NN	denotes	transition
T26717	8204-8207	VBP	denotes	are
T26718	8213-8215	IN	denotes	in
T26719	8216-8219	DT	denotes	the
T26720	8220-8227	NN	denotes	absence
T26721	8228-8230	IN	denotes	of
T26722	8231-8233	NN	denotes	Rb
T26723	8233-8235	,	denotes	,
T26724	8235-8242	VBP	denotes	migrate
T26725	8243-8245	IN	denotes	to
T26726	8246-8249	DT	denotes	the
T26727	8258-8263	NN	denotes	layer
T26728	8250-8257	JJ	denotes	correct
T26729	8263-8265	,	denotes	,
T26730	8265-8268	CC	denotes	and
T26731	8269-8276	VBP	denotes	express
T26732	8277-8288	JJ	denotes	appropriate
T26733	8289-8296	NNS	denotes	markers
T26734	8297-8298	-LRB-	denotes	(
T26735	8299-8300	CD	denotes	2
T26736	8298-8299	-LRB-	denotes	[
T26737	8300-8301	-RRB-	denotes	]
T26738	8302-8305	CC	denotes	and
T26739	8306-8310	DT	denotes	this
T26740	8311-8315	NN	denotes	work
T26741	8315-8316	-RRB-	denotes	)
T26742	8316-8317	.	denotes	.
T26743	8317-8602	sentence	denotes	In brain, Rb KO neurons migrate away from the ventricular zone and switch on Tubb3 (βIII-tubulin), but continue to incorporate BrdU [13], and in gut epithelia, differentiated enterocytes migrate up the villi and activate expression of serotonin, yet continue to incorporate BrdU [67].
T26744	8318-8320	IN	denotes	In
T26745	8342-8349	VBP	denotes	migrate
T26746	8321-8326	NN	denotes	brain
T26747	8326-8328	,	denotes	,
T26748	8328-8330	NN	denotes	Rb
T26749	8331-8333	NN	denotes	KO
T26750	8334-8341	NNS	denotes	neurons
T26751	8350-8354	RB	denotes	away
T26752	8355-8359	IN	denotes	from
T26753	8360-8363	DT	denotes	the
T26754	8376-8380	NN	denotes	zone
T26755	8364-8375	JJ	denotes	ventricular
T26756	8381-8384	CC	denotes	and
T26757	8385-8391	VBP	denotes	switch
T26758	8392-8394	RP	denotes	on
T26759	8395-8400	NN	denotes	Tubb3
T26760	8401-8402	-LRB-	denotes	(
T26761	8402-8406	NN	denotes	βIII
T26762	8407-8414	NN	denotes	tubulin
T26763	8406-8407	HYPH	denotes	-
T26764	8414-8415	-RRB-	denotes	)
T26765	8415-8417	,	denotes	,
T26766	8417-8420	CC	denotes	but
T26767	8421-8429	VBP	denotes	continue
T26768	8430-8432	TO	denotes	to
T26769	8433-8444	VB	denotes	incorporate
T26770	8445-8449	NN	denotes	BrdU
T26771	8450-8451	-LRB-	denotes	[
T26772	8451-8453	CD	denotes	13
T26773	8453-8454	-RRB-	denotes	]
T26774	8454-8456	,	denotes	,
T26775	8456-8459	CC	denotes	and
T26776	8460-8462	IN	denotes	in
T26777	8505-8512	VBP	denotes	migrate
T26778	8463-8466	NN	denotes	gut
T26779	8467-8476	NNS	denotes	epithelia
T26780	8476-8478	,	denotes	,
T26781	8478-8492	VBN	denotes	differentiated
T26782	8493-8504	NNS	denotes	enterocytes
T26783	8513-8515	IN	denotes	up
T26784	8516-8519	DT	denotes	the
T26785	8520-8525	NNS	denotes	villi
T26786	8526-8529	CC	denotes	and
T26787	8530-8538	VBP	denotes	activate
T26788	8539-8549	NN	denotes	expression
T26789	8550-8552	IN	denotes	of
T26790	8553-8562	NN	denotes	serotonin
T26791	8562-8564	,	denotes	,
T26792	8564-8567	CC	denotes	yet
T26793	8568-8576	VBP	denotes	continue
T26794	8577-8579	TO	denotes	to
T26795	8580-8591	VB	denotes	incorporate
T26796	8592-8596	NN	denotes	BrdU
T26797	8597-8598	-LRB-	denotes	[
T26798	8598-8600	CD	denotes	67
T26799	8600-8601	-RRB-	denotes	]
T26800	8601-8602	.	denotes	.
T26801	8602-8829	sentence	denotes	In the case of SACs, the differentiation defects we observed (e.g., loss of Slc18a3 and Chat) were not due to aberrant division, but it is possible there are other problems with these cells that are caused by ectopic division.
T26802	8603-8605	IN	denotes	In
T26803	8697-8701	VBD	denotes	were
T26804	8606-8609	DT	denotes	the
T26805	8610-8614	NN	denotes	case
T26806	8615-8617	IN	denotes	of
T26807	8618-8622	NNS	denotes	SACs
T26808	8622-8624	,	denotes	,
T26809	8624-8627	DT	denotes	the
T26810	8628-8643	NN	denotes	differentiation
T26811	8644-8651	VBZ	denotes	defects
T26812	8652-8654	PRP	denotes	we
T26813	8655-8663	VBD	denotes	observed
T26814	8664-8665	-LRB-	denotes	(
T26815	8665-8669	FW	denotes	e.g.
T26816	8671-8675	NN	denotes	loss
T26817	8669-8671	,	denotes	,
T26818	8676-8678	IN	denotes	of
T26819	8679-8686	NN	denotes	Slc18a3
T26820	8687-8690	CC	denotes	and
T26821	8691-8695	NN	denotes	Chat
T26822	8695-8696	-RRB-	denotes	)
T26823	8702-8705	RB	denotes	not
T26824	8706-8709	IN	denotes	due
T26825	8710-8712	IN	denotes	to
T26826	8713-8721	JJ	denotes	aberrant
T26827	8722-8730	NN	denotes	division
T26828	8730-8732	,	denotes	,
T26829	8732-8735	CC	denotes	but
T26830	8736-8738	PRP	denotes	it
T26831	8739-8741	VBZ	denotes	is
T26832	8742-8750	JJ	denotes	possible
T26833	8751-8756	EX	denotes	there
T26834	8757-8760	VBP	denotes	are
T26835	8761-8766	JJ	denotes	other
T26836	8767-8775	NNS	denotes	problems
T26837	8776-8780	IN	denotes	with
T26838	8781-8786	DT	denotes	these
T26839	8787-8792	NNS	denotes	cells
T26840	8793-8797	WDT	denotes	that
T26841	8802-8808	VBN	denotes	caused
T26842	8798-8801	VBP	denotes	are
T26843	8809-8811	IN	denotes	by
T26844	8812-8819	JJ	denotes	ectopic
T26845	8820-8828	NN	denotes	division
T26846	8828-8829	.	denotes	.
T26847	8829-8953	sentence	denotes	Nevertheless, it is clear that many aspects of differentiation in multiple cell types are compatible with ectopic division.
T26848	8830-8842	RB	denotes	Nevertheless
T26849	8847-8849	VBZ	denotes	is
T26850	8842-8844	,	denotes	,
T26851	8844-8846	PRP	denotes	it
T26852	8850-8855	JJ	denotes	clear
T26853	8856-8860	IN	denotes	that
T26854	8916-8919	VBP	denotes	are
T26855	8861-8865	JJ	denotes	many
T26856	8866-8873	NNS	denotes	aspects
T26857	8874-8876	IN	denotes	of
T26858	8877-8892	NN	denotes	differentiation
T26859	8893-8895	IN	denotes	in
T26860	8896-8904	JJ	denotes	multiple
T26861	8910-8915	NNS	denotes	types
T26862	8905-8909	NN	denotes	cell
T26863	8920-8930	JJ	denotes	compatible
T26864	8931-8935	IN	denotes	with
T26865	8936-8943	JJ	denotes	ectopic
T26866	8944-8952	NN	denotes	division
T26867	8952-8953	.	denotes	.
T26868	8953-9114	sentence	denotes	However, division of terminally differentiating cells is dangerous, since it may facilitate transformation, as is the case in retinoblastoma (reviewed in [66]).
T26869	8954-8961	RB	denotes	However
T26870	9008-9010	VBZ	denotes	is
T26871	8961-8963	,	denotes	,
T26872	8963-8971	NN	denotes	division
T26873	8972-8974	IN	denotes	of
T26874	8975-8985	RB	denotes	terminally
T26875	8986-9001	VBG	denotes	differentiating
T26876	9002-9007	NNS	denotes	cells
T26877	9011-9020	JJ	denotes	dangerous
T26878	9020-9022	,	denotes	,
T26879	9022-9027	IN	denotes	since
T26880	9035-9045	VB	denotes	facilitate
T26881	9028-9030	PRP	denotes	it
T26882	9031-9034	MD	denotes	may
T26883	9046-9060	NN	denotes	transformation
T26884	9060-9062	,	denotes	,
T26885	9062-9064	IN	denotes	as
T26886	9065-9067	VBZ	denotes	is
T26887	9068-9071	DT	denotes	the
T26888	9072-9076	NN	denotes	case
T26889	9077-9079	IN	denotes	in
T26890	9080-9094	NN	denotes	retinoblastoma
T26891	9095-9096	-LRB-	denotes	(
T26892	9096-9104	VBN	denotes	reviewed
T26893	9105-9107	IN	denotes	in
T26894	9108-9109	-LRB-	denotes	[
T26895	9109-9111	CD	denotes	66
T26896	9111-9112	-RRB-	denotes	]
T26897	9112-9113	-RRB-	denotes	)
T26898	9113-9114	.	denotes	.
T27309	9633-9639	IN	denotes	during
T27310	9640-9652	NN	denotes	neurogenesis
T27218	9116-9119	WRB	denotes	How
T27219	9131-9138	VB	denotes	Perturb
T27220	9120-9124	VBZ	denotes	Does
T27221	9125-9130	NN	denotes	E2f3a
T27222	9139-9142	NN	denotes	SAC
T27223	9143-9158	NN	denotes	Differentiation
T27224	9158-9159	.	denotes	?
T27225	9159-9377	sentence	denotes	E2f3a could disrupt SAC differentiation through its well known role as a transcriptional activator, or, in view of the discovery that it is partially cytoplasmic, E2f3a may affect processes other than gene regulation.
T27226	9160-9165	NN	denotes	E2f3a
T27227	9172-9179	VB	denotes	disrupt
T27228	9166-9171	MD	denotes	could
T27229	9180-9183	NN	denotes	SAC
T27230	9184-9199	NN	denotes	differentiation
T27231	9200-9207	IN	denotes	through
T27232	9208-9211	PRP$	denotes	its
T27233	9223-9227	NN	denotes	role
T27234	9212-9216	RB	denotes	well
T27235	9217-9222	VBN	denotes	known
T27236	9228-9230	IN	denotes	as
T27237	9231-9232	DT	denotes	a
T27238	9249-9258	NN	denotes	activator
T27239	9233-9248	JJ	denotes	transcriptional
T27240	9258-9260	,	denotes	,
T27241	9260-9262	CC	denotes	or
T27242	9262-9264	,	denotes	,
T27243	9264-9266	IN	denotes	in
T27244	9333-9339	VB	denotes	affect
T27245	9267-9271	NN	denotes	view
T27246	9272-9274	IN	denotes	of
T27247	9275-9278	DT	denotes	the
T27248	9279-9288	NN	denotes	discovery
T27249	9289-9293	IN	denotes	that
T27250	9297-9299	VBZ	denotes	is
T27251	9294-9296	PRP	denotes	it
T27252	9300-9309	RB	denotes	partially
T27253	9310-9321	JJ	denotes	cytoplasmic
T27254	9321-9323	,	denotes	,
T27255	9323-9328	NN	denotes	E2f3a
T27256	9329-9332	MD	denotes	may
T27257	9340-9349	NNS	denotes	processes
T27258	9350-9355	JJ	denotes	other
T27259	9356-9360	IN	denotes	than
T27260	9361-9365	NN	denotes	gene
T27261	9366-9376	NN	denotes	regulation
T27262	9376-9377	.	denotes	.
T27263	9377-9567	sentence	denotes	Both scenarios are feasible since E2fs regulate differentiation genes [44–48], and cell cycle regulators, such as Cdkn1b, have cytoplasmic activities that influence differentiation [68,69].
T27264	9378-9382	DT	denotes	Both
T27265	9383-9392	NNS	denotes	scenarios
T27266	9393-9396	VBP	denotes	are
T27267	9397-9405	JJ	denotes	feasible
T27268	9406-9411	IN	denotes	since
T27269	9417-9425	VBP	denotes	regulate
T27270	9412-9416	NNS	denotes	E2fs
T27271	9426-9441	NN	denotes	differentiation
T27272	9442-9447	NNS	denotes	genes
T27273	9448-9449	-LRB-	denotes	[
T27274	9449-9451	CD	denotes	44
T27275	9451-9452	SYM	denotes	–
T27276	9452-9454	CD	denotes	48
T27277	9454-9455	-RRB-	denotes	]
T27278	9455-9457	,	denotes	,
T27279	9457-9460	CC	denotes	and
T27280	9461-9465	NN	denotes	cell
T27281	9466-9471	NN	denotes	cycle
T27282	9472-9482	NNS	denotes	regulators
T27283	9500-9504	VBP	denotes	have
T27284	9482-9484	,	denotes	,
T27285	9484-9488	JJ	denotes	such
T27286	9489-9491	IN	denotes	as
T27287	9492-9498	NN	denotes	Cdkn1b
T27288	9498-9500	,	denotes	,
T27289	9505-9516	JJ	denotes	cytoplasmic
T27290	9517-9527	NNS	denotes	activities
T27291	9528-9532	WDT	denotes	that
T27292	9533-9542	VBP	denotes	influence
T27293	9543-9558	NN	denotes	differentiation
T27294	9559-9560	-LRB-	denotes	[
T27295	9563-9565	CD	denotes	69
T27296	9560-9562	CD	denotes	68
T27297	9562-9563	,	denotes	,
T27298	9565-9566	-RRB-	denotes	]
T27299	9566-9567	.	denotes	.
T27300	9567-9689	sentence	denotes	Many transcription factors shuttle between nucleus and cytoplasm during neurogenesis (e.g., [70] and references therein).
T27301	9568-9572	JJ	denotes	Many
T27302	9587-9594	NNS	denotes	factors
T27303	9573-9586	NN	denotes	transcription
T27304	9595-9602	VBP	denotes	shuttle
T27305	9603-9610	IN	denotes	between
T27306	9611-9618	NN	denotes	nucleus
T27307	9619-9622	CC	denotes	and
T27308	9623-9632	NN	denotes	cytoplasm
T27311	9653-9654	-LRB-	denotes	(
T27312	9661-9663	CD	denotes	70
T27313	9654-9658	FW	denotes	e.g.
T27314	9658-9660	,	denotes	,
T27315	9660-9661	-LRB-	denotes	[
T27316	9663-9664	-RRB-	denotes	]
T27317	9665-9668	CC	denotes	and
T27318	9669-9679	NNS	denotes	references
T27319	9680-9687	RB	denotes	therein
T27320	9687-9688	-RRB-	denotes	)
T27321	9688-9689	.	denotes	.
T27322	9689-9891	sentence	denotes	It may be difficult to identify E2f3a-specific target genes or cytoplasmic proteins in SACs since these neurons are a small proportion (<1%) of the total retina and only ~5.2% of amacrine neurons [38].
T27323	9690-9692	PRP	denotes	It
T27324	9697-9699	VB	denotes	be
T27325	9693-9696	MD	denotes	may
T27326	9700-9709	JJ	denotes	difficult
T27327	9710-9712	TO	denotes	to
T27328	9713-9721	VB	denotes	identify
T27329	9722-9727	NN	denotes	E2f3a
T27330	9728-9736	JJ	denotes	specific
T27331	9727-9728	HYPH	denotes	-
T27332	9744-9749	NNS	denotes	genes
T27333	9737-9743	NN	denotes	target
T27334	9750-9752	CC	denotes	or
T27335	9753-9764	JJ	denotes	cytoplasmic
T27336	9765-9773	NN	denotes	proteins
T27337	9774-9776	IN	denotes	in
T27338	9777-9781	NNS	denotes	SACs
T27339	9782-9787	IN	denotes	since
T27340	9802-9805	VBP	denotes	are
T27341	9788-9793	DT	denotes	these
T27342	9794-9801	NNS	denotes	neurons
T27343	9806-9807	DT	denotes	a
T27344	9814-9824	NN	denotes	proportion
T27345	9808-9813	JJ	denotes	small
T27346	9825-9826	-LRB-	denotes	(
T27347	9826-9827	SYM	denotes	<
T27348	9827-9828	CD	denotes	1
T27349	9828-9829	NN	denotes	%
T27350	9829-9830	-RRB-	denotes	)
T27351	9831-9833	IN	denotes	of
T27352	9834-9837	DT	denotes	the
T27353	9844-9850	NN	denotes	retina
T27354	9838-9843	JJ	denotes	total
T27355	9851-9854	CC	denotes	and
T27356	9855-9859	RB	denotes	only
T27357	9861-9864	CD	denotes	5.2
T27358	9860-9861	SYM	denotes	~
T27359	9864-9865	NN	denotes	%
T27360	9866-9868	IN	denotes	of
T27361	9869-9877	JJ	denotes	amacrine
T27362	9878-9885	NNS	denotes	neurons
T27363	9886-9887	-LRB-	denotes	[
T27364	9887-9889	CD	denotes	38
T27365	9889-9890	-RRB-	denotes	]
T27366	9890-9891	.	denotes	.
T27799	9913-9915	NN	denotes	Rb
T27800	9925-9926	.	denotes	?
T27794	9893-9895	VBP	denotes	Do
T27795	9901-9908	VB	denotes	Mediate
T27796	9896-9900	NNS	denotes	E2fs
T27797	9909-9912	DT	denotes	All
T27798	9916-9925	NNS	denotes	Functions
T27801	9926-10042	sentence	denotes	Others have suggested that Rb promotes differentiation in non-neuronal cells through E2f-independent means [31–33].
T27802	9927-9933	NNS	denotes	Others
T27803	9939-9948	VBN	denotes	suggested
T27804	9934-9938	VBP	denotes	have
T27805	9949-9953	IN	denotes	that
T27806	9957-9965	VBZ	denotes	promotes
T27807	9954-9956	NN	denotes	Rb
T27808	9966-9981	NN	denotes	differentiation
T27809	9982-9984	IN	denotes	in
T27810	9985-9997	JJ	denotes	non-neuronal
T27811	9998-10003	NNS	denotes	cells
T27812	10004-10011	IN	denotes	through
T27813	10012-10015	NN	denotes	E2f
T27814	10016-10027	JJ	denotes	independent
T27815	10015-10016	HYPH	denotes	-
T27816	10028-10033	NNS	denotes	means
T27817	10034-10035	-LRB-	denotes	[
T27818	10035-10037	CD	denotes	31
T27819	10037-10038	SYM	denotes	–
T27820	10038-10040	CD	denotes	33
T27821	10040-10041	-RRB-	denotes	]
T27822	10041-10042	.	denotes	.
T27823	10042-10188	sentence	denotes	However, these studies did not assess whether these cell types differentiate normally if Rb is deleted along with one or more E2f family members.
T27824	10043-10050	RB	denotes	However
T27825	10074-10080	VB	denotes	assess
T27826	10050-10052	,	denotes	,
T27827	10052-10057	DT	denotes	these
T27828	10058-10065	NNS	denotes	studies
T27829	10066-10069	VBD	denotes	did
T27830	10070-10073	RB	denotes	not
T27831	10081-10088	IN	denotes	whether
T27832	10106-10119	VBP	denotes	differentiate
T27833	10089-10094	DT	denotes	these
T27834	10100-10105	NNS	denotes	types
T27835	10095-10099	NN	denotes	cell
T27836	10120-10128	RB	denotes	normally
T27837	10129-10131	IN	denotes	if
T27838	10138-10145	VBN	denotes	deleted
T27839	10132-10134	NN	denotes	Rb
T27840	10135-10137	VBZ	denotes	is
T27841	10146-10151	IN	denotes	along
T27842	10152-10156	IN	denotes	with
T27843	10157-10160	CD	denotes	one
T27844	10180-10187	NNS	denotes	members
T27845	10161-10163	CC	denotes	or
T27846	10164-10168	JJR	denotes	more
T27847	10169-10172	NN	denotes	E2f
T27848	10173-10179	NN	denotes	family
T27849	10187-10188	.	denotes	.
T27850	10188-10279	sentence	denotes	One study reported that Rb mutants that do not bind E2f still induce differentiation [30].
T27851	10189-10192	CD	denotes	One
T27852	10193-10198	NN	denotes	study
T27853	10199-10207	VBD	denotes	reported
T27854	10208-10212	IN	denotes	that
T27855	10251-10257	VBP	denotes	induce
T27856	10213-10215	NN	denotes	Rb
T27857	10216-10223	NNS	denotes	mutants
T27858	10224-10228	WDT	denotes	that
T27859	10236-10240	VB	denotes	bind
T27860	10229-10231	VBP	denotes	do
T27861	10232-10235	RB	denotes	not
T27862	10241-10244	NN	denotes	E2f
T27863	10245-10250	RB	denotes	still
T27864	10258-10273	NN	denotes	differentiation
T27865	10274-10275	-LRB-	denotes	[
T27866	10275-10277	CD	denotes	30
T27867	10277-10278	-RRB-	denotes	]
T27868	10278-10279	.	denotes	.
T27869	10279-10461	sentence	denotes	However, the binding assays were performed in solution, and we have found that several of these mutants do bind E2f, albeit weakly, on chromatin (T. Yu and R. B., unpublished data).
T27870	10280-10287	RB	denotes	However
T27871	10313-10322	VBN	denotes	performed
T27872	10287-10289	,	denotes	,
T27873	10289-10292	DT	denotes	the
T27874	10301-10307	NNS	denotes	assays
T27875	10293-10300	NN	denotes	binding
T27876	10308-10312	VBD	denotes	were
T27877	10323-10325	IN	denotes	in
T27878	10326-10334	NN	denotes	solution
T27879	10334-10336	,	denotes	,
T27880	10336-10339	CC	denotes	and
T27881	10340-10342	PRP	denotes	we
T27882	10348-10353	VBN	denotes	found
T27883	10343-10347	VBP	denotes	have
T27884	10354-10358	IN	denotes	that
T27885	10387-10391	VB	denotes	bind
T27886	10359-10366	JJ	denotes	several
T27887	10367-10369	IN	denotes	of
T27888	10370-10375	DT	denotes	these
T27889	10376-10383	NNS	denotes	mutants
T27890	10384-10386	VBP	denotes	do
T27891	10392-10395	NN	denotes	E2f
T27892	10395-10397	,	denotes	,
T27893	10397-10403	IN	denotes	albeit
T27894	10404-10410	RB	denotes	weakly
T27895	10410-10412	,	denotes	,
T27896	10412-10414	IN	denotes	on
T27897	10415-10424	NN	denotes	chromatin
T27898	10425-10426	-LRB-	denotes	(
T27899	10426-10428	NNP	denotes	T.
T27900	10429-10431	NNP	denotes	Yu
T27901	10432-10435	CC	denotes	and
T27902	10436-10438	NNP	denotes	R.
T27903	10439-10441	NNP	denotes	B.
T27904	10441-10443	,	denotes	,
T27905	10443-10454	JJ	denotes	unpublished
T27906	10455-10459	NNS	denotes	data
T27907	10459-10460	-RRB-	denotes	)
T27908	10460-10461	.	denotes	.
T27909	10461-10659	sentence	denotes	It is possible that Rb-mediated potentiation of tissue-specific transcription factors may, at least in some cases, be a redundant activity, and that the only critical Rb function is to inhibit E2f.
T27910	10462-10464	PRP	denotes	It
T27911	10465-10467	VBZ	denotes	is
T27912	10468-10476	JJ	denotes	possible
T27913	10477-10481	IN	denotes	that
T27914	10577-10579	VB	denotes	be
T27915	10482-10484	NN	denotes	Rb
T27916	10485-10493	VBN	denotes	mediated
T27917	10484-10485	HYPH	denotes	-
T27918	10494-10506	NN	denotes	potentiation
T27919	10507-10509	IN	denotes	of
T27920	10510-10516	NN	denotes	tissue
T27921	10517-10525	JJ	denotes	specific
T27922	10516-10517	HYPH	denotes	-
T27923	10540-10547	NNS	denotes	factors
T27924	10526-10539	NN	denotes	transcription
T27925	10548-10551	MD	denotes	may
T27926	10551-10553	,	denotes	,
T27927	10553-10555	RB	denotes	at
T27928	10556-10561	RBS	denotes	least
T27929	10562-10564	IN	denotes	in
T27930	10565-10569	DT	denotes	some
T27931	10570-10575	NNS	denotes	cases
T27932	10575-10577	,	denotes	,
T27933	10580-10581	DT	denotes	a
T27934	10592-10600	NN	denotes	activity
T27935	10582-10591	JJ	denotes	redundant
T27936	10600-10602	,	denotes	,
T27937	10602-10605	CC	denotes	and
T27938	10606-10610	IN	denotes	that
T27939	10641-10643	VBZ	denotes	is
T27940	10611-10614	DT	denotes	the
T27941	10632-10640	NN	denotes	function
T27942	10615-10619	JJ	denotes	only
T27943	10620-10628	JJ	denotes	critical
T27944	10629-10631	NN	denotes	Rb
T27945	10644-10646	TO	denotes	to
T27946	10647-10654	VB	denotes	inhibit
T27947	10655-10658	NN	denotes	E2f
T27948	10658-10659	.	denotes	.
T27949	10659-10797	sentence	denotes	Our study is the first to our knowledge to assess comprehensively whether Rb KO cells can differentiate in the absence of different E2fs.
T27950	10660-10663	PRP$	denotes	Our
T27951	10664-10669	NN	denotes	study
T27952	10670-10672	VBZ	denotes	is
T27953	10673-10676	DT	denotes	the
T27954	10677-10682	JJ	denotes	first
T27955	10683-10685	IN	denotes	to
T27956	10686-10689	PRP$	denotes	our
T27957	10690-10699	NN	denotes	knowledge
T27958	10700-10702	TO	denotes	to
T27959	10703-10709	VB	denotes	assess
T27960	10710-10725	RB	denotes	comprehensively
T27961	10726-10733	IN	denotes	whether
T27962	10750-10763	VB	denotes	differentiate
T27963	10734-10736	NN	denotes	Rb
T27964	10737-10739	NN	denotes	KO
T27965	10740-10745	NNS	denotes	cells
T27966	10746-10749	MD	denotes	can
T27967	10764-10766	IN	denotes	in
T27968	10767-10770	DT	denotes	the
T27969	10771-10778	NN	denotes	absence
T27970	10779-10781	IN	denotes	of
T27971	10782-10791	JJ	denotes	different
T27972	10792-10796	NNS	denotes	E2fs
T27973	10796-10797	.	denotes	.
T27974	10797-10976	sentence	denotes	In light of our findings, it will be important to reassess differentiation defects in other Rb KO tissues in the absence of individual and combined activating E2f family members.
T27975	10798-10800	IN	denotes	In
T27976	10832-10834	VB	denotes	be
T27977	10801-10806	NN	denotes	light
T27978	10807-10809	IN	denotes	of
T27979	10810-10813	PRP$	denotes	our
T27980	10814-10822	NNS	denotes	findings
T27981	10822-10824	,	denotes	,
T27982	10824-10826	PRP	denotes	it
T27983	10827-10831	MD	denotes	will
T27984	10835-10844	JJ	denotes	important
T27985	10845-10847	TO	denotes	to
T27986	10848-10856	VB	denotes	reassess
T27987	10857-10872	NN	denotes	differentiation
T27988	10873-10880	NNS	denotes	defects
T27989	10881-10883	IN	denotes	in
T27990	10884-10889	JJ	denotes	other
T27991	10896-10903	NNS	denotes	tissues
T27992	10890-10892	NN	denotes	Rb
T27993	10893-10895	NN	denotes	KO
T27994	10904-10906	IN	denotes	in
T27995	10907-10910	DT	denotes	the
T27996	10911-10918	NN	denotes	absence
T27997	10919-10921	IN	denotes	of
T27998	10922-10932	JJ	denotes	individual
T27999	10968-10975	NNS	denotes	members
T28000	10933-10936	CC	denotes	and
T28001	10937-10945	VBN	denotes	combined
T28002	10946-10956	VBG	denotes	activating
T28003	10957-10960	NN	denotes	E2f
T28004	10961-10967	NN	denotes	family
T28005	10975-10976	.	denotes	.
T38541	3911-3913	NN	denotes	Rb
T38542	3914-3923	VBZ	denotes	Regulates
T38543	3924-3932	JJ	denotes	Distinct
T38544	3933-3942	NNS	denotes	Processes
T38545	3943-3950	IN	denotes	through
T38546	3951-3955	NN	denotes	E2f1
T38547	3956-3959	CC	denotes	and
T38548	3960-3965	NN	denotes	E2f3a
T38549	3965-4015	sentence	denotes	Red text and arrows indicate Rb-dependent events.
T38550	3966-3969	JJ	denotes	Red
T38551	3970-3974	NN	denotes	text
T38552	3986-3994	VBP	denotes	indicate
T38553	3975-3978	CC	denotes	and
T38554	3979-3985	NNS	denotes	arrows
T38555	3995-3997	NN	denotes	Rb
T38556	3998-4007	JJ	denotes	dependent
T38557	3997-3998	HYPH	denotes	-
T38558	4008-4014	NNS	denotes	events
T38559	4014-4015	.	denotes	.
T38560	4015-4110	sentence	denotes	Black text and arrows indicate events for which there is no direct evidence of Rb involvement.
T38561	4016-4021	JJ	denotes	Black
T38562	4022-4026	NN	denotes	text
T38563	4038-4046	VBP	denotes	indicate
T38564	4027-4030	CC	denotes	and
T38565	4031-4037	NNS	denotes	arrows
T38566	4047-4053	NNS	denotes	events
T38567	4054-4057	IN	denotes	for
T38568	4070-4072	VBZ	denotes	is
T38569	4058-4063	WDT	denotes	which
T38570	4064-4069	EX	denotes	there
T38571	4073-4075	DT	denotes	no
T38572	4083-4091	NN	denotes	evidence
T38573	4076-4082	JJ	denotes	direct
T38574	4092-4094	IN	denotes	of
T38575	4095-4097	NN	denotes	Rb
T38576	4098-4109	NN	denotes	involvement
T38577	4109-4110	.	denotes	.
T38578	4110-4302	sentence	denotes	Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle.
T38579	4111-4113	NN	denotes	Rb
T38580	4123-4129	VB	denotes	appear
T38581	4114-4118	VBZ	denotes	does
T38582	4119-4122	RB	denotes	not
T38583	4130-4132	TO	denotes	to
T38584	4133-4139	VB	denotes	temper
T38585	4140-4143	NN	denotes	RPC
T38586	4144-4153	NN	denotes	expansion
T38587	4154-4157	CC	denotes	and
T38588	4158-4160	VBZ	denotes	is
T38589	4165-4173	VBN	denotes	required
T38590	4161-4164	RB	denotes	not
T38591	4174-4177	IN	denotes	for
T38592	4178-4193	NN	denotes	differentiation
T38593	4194-4196	IN	denotes	of
T38594	4197-4201	NNS	denotes	RPCs
T38595	4202-4206	IN	denotes	into
T38596	4207-4211	NNS	denotes	RTCs
T38597	4211-4213	,	denotes	,
T38598	4213-4216	CC	denotes	but
T38599	4217-4219	VBZ	denotes	is
T38600	4220-4229	JJ	denotes	essential
T38601	4230-4232	TO	denotes	to
T38602	4233-4239	VB	denotes	couple
T38603	4240-4243	NN	denotes	RTC
T38604	4244-4249	NN	denotes	birth
T38605	4250-4252	IN	denotes	to
T38606	4253-4261	JJ	denotes	terminal
T38607	4262-4269	NN	denotes	mitosis
T38608	4269-4271	,	denotes	,
T38609	4271-4275	RB	denotes	thus
T38610	4276-4283	VBG	denotes	locking
T38611	4284-4288	PRP	denotes	them
T38612	4289-4292	RB	denotes	out
T38613	4293-4295	IN	denotes	of
T38614	4296-4301	NN	denotes	cycle
T38615	4301-4302	.	denotes	.
T38616	4302-4348	sentence	denotes	Rb performs this function by inhibiting E2f1.
T38617	4303-4305	NN	denotes	Rb
T38618	4306-4314	VBZ	denotes	performs
T38619	4315-4319	DT	denotes	this
T38620	4320-4328	NN	denotes	function
T38621	4329-4331	IN	denotes	by
T38622	4332-4342	VBG	denotes	inhibiting
T38623	4343-4347	NN	denotes	E2f1
T38624	4347-4348	.	denotes	.
T38625	4348-4437	sentence	denotes	Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a.
T38626	4349-4351	NN	denotes	Rb
T38627	4360-4368	VBN	denotes	required
T38628	4352-4354	VBZ	denotes	is
T38629	4355-4359	RB	denotes	also
T38630	4369-4372	IN	denotes	for
T38631	4373-4376	NN	denotes	SAC
T38632	4377-4392	NN	denotes	differentiation
T38633	4392-4394	,	denotes	,
T38634	4394-4397	CC	denotes	and
T38635	4398-4400	IN	denotes	in
T38636	4412-4416	VBZ	denotes	acts
T38637	4401-4405	DT	denotes	this
T38638	4406-4410	NN	denotes	case
T38639	4410-4412	,	denotes	,
T38640	4417-4419	IN	denotes	by
T38641	4420-4430	VBG	denotes	inhibiting
T38642	4431-4436	NN	denotes	E2f3a
T38643	4436-4437	.	denotes	.
T38644	4437-4535	sentence	denotes	There is no direct evidence that Rb is required for terminal differentiation of other cell types.
T38645	4438-4443	EX	denotes	There
T38646	4444-4446	VBZ	denotes	is
T38647	4447-4449	DT	denotes	no
T38648	4457-4465	NN	denotes	evidence
T38649	4450-4456	JJ	denotes	direct
T38650	4466-4470	IN	denotes	that
T38651	4477-4485	VBN	denotes	required
T38652	4471-4473	NN	denotes	Rb
T38653	4474-4476	VBZ	denotes	is
T38654	4486-4489	IN	denotes	for
T38655	4490-4498	JJ	denotes	terminal
T38656	4499-4514	NN	denotes	differentiation
T38657	4515-4517	IN	denotes	of
T38658	4518-4523	JJ	denotes	other
T38659	4529-4534	NNS	denotes	types
T38660	4524-4528	NN	denotes	cell
T38661	4534-4535	.	denotes	.
T38662	4535-4583	sentence	denotes	Colour codes and abbreviations as in Figure 1A.
T38663	4536-4542	NN	denotes	Colour
T38664	4543-4548	NNS	denotes	codes
T38665	4549-4552	CC	denotes	and
T38666	4553-4566	NNS	denotes	abbreviations
T38667	4567-4569	IN	denotes	as
T38668	4570-4572	IN	denotes	in
T38669	4573-4579	NN	denotes	Figure
T38670	4580-4582	NN	denotes	1A
T38671	4582-4583	.	denotes	.
T24729	3562-3570	JJ	denotes	specific
T24730	3561-3562	HYPH	denotes	-
T24731	3585-3592	NNS	denotes	factors
T24732	3571-3584	NN	denotes	transcription
T24733	3593-3597	WDT	denotes	that
T24734	3598-3605	VBP	denotes	promote
T24735	3606-3621	NN	denotes	differentiation
T24736	3622-3623	-LRB-	denotes	[
T24737	3623-3625	CD	denotes	31
T24814	4623-4624	EX	denotes	r
T24815	4624-4625	DT	denotes	o
T24816	4625-4626	VBN	denotes	u
T24817	4626-4627	sentence	denotes	g
T24818	4626-4627	NN	denotes	g
T24821	4627-4628	IN	denotes	h
T24822	4629-4633	NN	denotes	E2f3
T24823	4710-4717	VBD	denotes	rescued
T24824	4638-4649	JJ	denotes	independent
T24825	4650-4652	IN	denotes	of
T24717	3491-3499	JJ	denotes	skeletal
T24718	3500-3506	NN	denotes	muscle
T24719	3506-3508	,	denotes	,
T24720	3508-3518	NNS	denotes	adipocytes
T24721	3518-3520	,	denotes	,
T24722	3520-3523	CC	denotes	and
T24723	3524-3528	NN	denotes	bone
T24724	3528-3530	,	denotes	,
T24725	3530-3532	PRP	denotes	it
T24726	3539-3542	CC	denotes	and
T24727	3543-3554	VBZ	denotes	potentiates
T24728	3555-3561	NN	denotes	tissue
T24800	3917-4601	sentence	denotes	ulates Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulation of
T24801	3917-3918	VBN	denotes	u
T24802	3918-3919	JJ	denotes	l
T24803	3919-3920	JJ	denotes	a
T24804	3920-4595	NN	denotes	tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati
T24805	4595-4597	VBG	denotes	on
T24806	4598-4599	RB	denotes	o
T24807	4599-4600	IN	denotes	f
T24808	4601-4623	sentence	denotes	SAC differentiation th
T24809	4601-4604	NN	denotes	SAC
T24810	4605-4620	NN	denotes	differentiation
T24811	4620-4621	,	denotes
T24812	4621-4623	DT	denotes	th
T24813	4623-4626	sentence	denotes	rou
T24819	4627-4893	sentence	denotes	h E2f3 was independent of its role in controlling division or death: E2f3 deletion rescued Rb KO SAC defects but did not suppress aberrant proliferation or death, whereas E2f1 deletion reversed abnormal proliferation and death but did not rescue SAC differentiation.
T24820	4634-4637	VBD	denotes	was
R6616	T23003	T23004	nsubj	Rb,Controls
R6617	T23005	T23006	amod	Retinal,Cell
R6618	T23006	T23004	dobj	Cell,Controls
R6619	T23007	T23006	appos	Division,Cell
R6620	T23008	T23007	cc	and,Division
R6621	T23009	T23007	conj	Death,Division
R6622	T23010	T23004	prep	through,Controls
R6623	T23011	T23010	pobj	E2f1,through
R6624	T23013	T23014	nsubj	Work,showed
R6625	T23015	T23013	prep	in,Work
R6626	T23016	T23017	det	the,1990s
R6627	T23017	T23015	pobj	1990s,in
R6628	T23018	T23017	amod	early,1990s
R6629	T23019	T23020	mark	that,triggers
R6630	T23020	T23014	ccomp	triggers,showed
R6631	T23021	T23022	compound	Rb,loss
R6632	T23022	T23020	nsubj	loss,triggers
R6633	T23023	T23020	dobj	defects,triggers
R6634	T23024	T23023	prep	in,defects
R6635	T23025	T23026	amod	neuronal,exit
R6636	T23026	T23024	pobj	exit,in
R6637	T23027	T23028	compound	cell,cycle
R6638	T23028	T23026	compound	cycle,exit
R6639	T23029	T23026	punct	", ",exit
R6640	T23030	T23026	conj	survival,exit
R6641	T23031	T23030	punct	", ",survival
R6642	T23032	T23030	cc	and,survival
R6643	T23033	T23030	conj	differentiation,survival
R6644	T23034	T23035	punct	[,26
R6645	T23035	T23020	parataxis	26,triggers
R6646	T23036	T23037	punct	–,28
R6647	T23037	T23035	prep	28,26
R6648	T23038	T23035	punct	],26
R6649	T23039	T23014	punct	.,showed
R6650	T23041	T23042	nsubj	Much,is
R6651	T23043	T23041	prep	of,Much
R6652	T23044	T23045	det	the,death
R6653	T23045	T23043	pobj	death,of
R6654	T23046	T23047	det	an,consequence
R6655	T23047	T23042	attr	consequence,is
R6656	T23048	T23047	amod	indirect,consequence
R6657	T23049	T23047	prep	of,consequence
R6658	T23050	T23051	amod	probable,hypoxia
R6659	T23051	T23049	pobj	hypoxia,of
R6660	T23052	T23051	acl	linked,hypoxia
R6661	T23053	T23052	prep	to,linked
R6662	T23054	T23055	amod	placental,defects
R6663	T23055	T23053	pobj	defects,to
R6664	T23056	T23057	punct	[,12
R6665	T23057	T23052	parataxis	12,linked
R6666	T23058	T23059	punct	–,14
R6667	T23059	T23057	prep	14,12
R6668	T23060	T23057	punct	],12
R6669	T23061	T23042	punct	.,is
R6670	T23063	T23064	advmod	However,reveal
R6671	T23065	T23064	punct	", ",reveal
R6672	T23066	T23067	amod	targeted,KO
R6673	T23067	T23068	nmod	KO,studies
R6674	T23068	T23064	nsubj	studies,reveal
R6675	T23069	T23067	cc	and,KO
R6676	T23070	T23067	conj	chimeric,KO
R6677	T23071	T23072	mark	that,promotes
R6678	T23072	T23064	ccomp	promotes,reveal
R6679	T23073	T23072	nsubj	Rb,promotes
R6680	T23074	T23072	advmod	autonomously,promotes
R6681	T23075	T23076	compound	cell,cycle
R6682	T23076	T23077	compound	cycle,exit
R6683	T23077	T23072	dobj	exit,promotes
R6684	T23078	T23072	prep	in,promotes
R6685	T23079	T23080	amod	newborn,neurons
R6686	T23080	T23078	pobj	neurons,in
R6687	T23081	T23072	punct	", ",promotes
R6688	T23082	T23072	cc	and,promotes
R6689	T23083	T23084	auxpass	is,required
R6690	T23084	T23072	conj	required,promotes
R6691	T23085	T23084	prep	for,required
R6692	T23086	T23085	pobj	survival,for
R6693	T23087	T23086	prep	of,survival
R6694	T23088	T23089	det	a,subset
R6695	T23089	T23087	pobj	subset,of
R6696	T23090	T23089	prep	of,subset
R6697	T23091	T23090	pobj	neurons,of
R6698	T23092	T23084	punct	", ",required
R6699	T23093	T23094	advmod	particularly,in
R6700	T23094	T23084	prep	in,required
R6701	T23095	T23096	det	the,retina
R6702	T23096	T23094	pobj	retina,in
R6703	T23097	T23098	punct	[,2
R6704	T23098	T23064	parataxis	2,reveal
R6705	T23099	T23098	punct	",",2
R6706	T23100	T23098	appos	3,2
R6707	T23101	T23098	punct	",",2
R6708	T23102	T23098	appos	13,2
R6709	T23103	T23098	punct	",",2
R6710	T23104	T23098	appos	14,2
R6711	T23105	T23098	punct	",",2
R6712	T23106	T23098	appos	56,2
R6713	T23107	T23108	punct	–,59
R6714	T23108	T23106	prep	59,56
R6715	T23109	T23098	punct	],2
R6716	T23110	T23064	punct	.,reveal
R6717	T23112	T23113	advmod	However,obscured
R6718	T23114	T23113	punct	", ",obscured
R6719	T23115	T23116	mark	whether,regulates
R6720	T23116	T23113	csubjpass	regulates,obscured
R6721	T23117	T23116	nsubj	Rb,regulates
R6722	T23118	T23116	advmod	also,regulates
R6723	T23119	T23116	dobj	differentiation,regulates
R6724	T23120	T23113	auxpass	is,obscured
R6725	T23121	T23113	agent	by,obscured
R6726	T23122	T23123	advmod	potentially,indirect
R6727	T23123	T23124	amod	indirect,effects
R6728	T23124	T23121	pobj	effects,by
R6729	T23125	T23124	prep	of,effects
R6730	T23126	T23127	amod	ectopic,division
R6731	T23127	T23125	pobj	division,of
R6732	T23128	T23127	cc	and,division
R6733	T23129	T23127	conj	death,division
R6734	T23130	T23113	punct	.,obscured
R6735	T23132	T23133	advmod	Moreover,elucidated
R6736	T23134	T23133	punct	", ",elucidated
R6737	T23135	T23136	det	a,mechanism
R6738	T23136	T23133	nsubjpass	mechanism,elucidated
R6739	T23137	T23138	prep	though,regulate
R6740	T23138	T23136	relcl	regulate,mechanism
R6741	T23139	T23137	pobj	which,though
R6742	T23140	T23138	nsubj	Rb,regulate
R6743	T23141	T23138	aux	may,regulate
R6744	T23142	T23143	amod	neuronal,maturation
R6745	T23143	T23138	dobj	maturation,regulate
R6746	T23144	T23133	aux	has,elucidated
R6747	T23145	T23133	neg	not,elucidated
R6748	T23146	T23133	auxpass	been,elucidated
R6749	T23147	T23133	punct	.,elucidated
R6750	T23149	T23150	advmod	Here,rescued
R6751	T23151	T23150	punct	", ",rescued
R6752	T23152	T23150	csubj	deleting,rescued
R6753	T23153	T23152	dobj	E2f1,deleting
R6754	T23154	T23150	advmod	specifically,rescued
R6755	T23155	T23156	amod	ectopic,division
R6756	T23156	T23150	dobj	division,rescued
R6757	T23157	T23156	cc	and,division
R6758	T23158	T23156	conj	death,division
R6759	T23159	T23150	prep	in,rescued
R6760	T23160	T23161	det	the,retina
R6761	T23161	T23159	pobj	retina,in
R6762	T23162	T23163	compound	Rb,KO
R6763	T23163	T23161	compound	KO,retina
R6764	T23164	T23150	punct	.,rescued
R6765	T23166	T23167	advmod	Importantly,differentiated
R6766	T23168	T23167	punct	", ",differentiated
R6767	T23169	T23170	amod	major,neurons
R6768	T23170	T23167	nsubj	neurons,differentiated
R6769	T23171	T23172	compound	Rb,E2f1
R6770	T23172	T23174	compound	E2f1,DKO
R6771	T23173	T23172	punct	/,E2f1
R6772	T23174	T23170	compound	DKO,neurons
R6773	T23175	T23167	advmod	normally,differentiated
R6774	T23176	T23167	punct	", ",differentiated
R6775	T23177	T23167	cc	and,differentiated
R6776	T23178	T23179	nsubj	ERGs,revealed
R6777	T23179	T23167	conj	revealed,differentiated
R6778	T23180	T23181	det	the,rescue
R6779	T23181	T23179	dobj	rescue,revealed
R6780	T23182	T23181	prep	of,rescue
R6781	T23183	T23184	npadvmod	rod,mediated
R6782	T23184	T23189	amod	mediated,function
R6783	T23185	T23183	punct	-,rod
R6784	T23186	T23183	cc	and,rod
R6785	T23187	T23183	conj	cone,rod
R6786	T23188	T23184	punct	-,mediated
R6787	T23189	T23182	pobj	function,of
R6788	T23190	T23179	punct	", ",revealed
R6789	T23191	T23179	advcl	implicating,revealed
R6790	T23192	T23193	det	a,flow
R6791	T23193	T23191	dobj	flow,implicating
R6792	T23194	T23193	amod	regular,flow
R6793	T23195	T23193	compound	signal,flow
R6794	T23196	T23193	prep	from,flow
R6795	T23197	T23196	pobj	photoreceptors,from
R6796	T23198	T23193	prep	to,flow
R6797	T23199	T23200	amod	bipolar,cells
R6798	T23200	T23198	pobj	cells,to
R6799	T23201	T23199	cc	and,bipolar
R6800	T23202	T23199	conj	amacrine,bipolar
R6801	T23203	T23179	punct	.,revealed
R6802	T23205	T23206	nmod	Division,genes
R6803	T23206	T23209	nsubjpass	genes,induced
R6804	T23207	T23205	cc	and,Division
R6805	T23208	T23205	conj	death,Division
R6806	T23210	T23209	auxpass	were,induced
R6807	T23211	T23209	prep	in,induced
R6808	T23212	T23213	compound	Rb,KO
R6809	T23213	T23214	compound	KO,cells
R6810	T23214	T23211	pobj	cells,in
R6811	T23215	T23209	punct	", ",induced
R6812	T23216	T23209	cc	and,induced
R6813	T23217	T23218	csubj	deleting,reversed
R6814	T23218	T23209	conj	reversed,induced
R6815	T23219	T23217	dobj	E2f1,deleting
R6816	T23220	T23219	punct	", ",E2f1
R6817	T23221	T23219	cc	but,E2f1
R6818	T23222	T23221	neg	not,but
R6819	T23223	T23219	conj	E2f2,E2f1
R6820	T23224	T23223	cc	or,E2f2
R6821	T23225	T23223	conj	E2f3,E2f2
R6822	T23226	T23218	punct	", ",reversed
R6823	T23227	T23228	det	these,events
R6824	T23228	T23218	dobj	events,reversed
R6825	T23229	T23228	amod	molecular,events
R6826	T23230	T23218	punct	.,reversed
R6827	T23232	T23233	nsubj	E2f1,regulate
R6828	T23234	T23233	aux	may,regulate
R6829	T23235	T23233	advmod	also,regulate
R6830	T23236	T23237	compound	differentiation,targets
R6831	T23237	T23233	dobj	targets,regulate
R6832	T23238	T23233	punct	", ",regulate
R6833	T23239	T23233	cc	but,regulate
R6834	T23240	T23241	mark	whether,contributes
R6835	T23241	T23243	csubj	contributes,is
R6836	T23242	T23241	nsubj	this,contributes
R6837	T23243	T23233	conj	is,regulate
R6838	T23244	T23241	prep	to,contributes
R6839	T23245	T23244	pobj	defects,to
R6840	T23246	T23245	prep	in,defects
R6841	T23247	T23248	amod	retinal,cell
R6842	T23248	T23249	compound	cell,maturation
R6843	T23249	T23246	pobj	maturation,in
R6844	T23250	T23243	acomp	impossible,is
R6845	T23251	T23252	aux	to,separate
R6846	T23252	T23250	xcomp	separate,impossible
R6847	T23253	T23252	prep	from,separate
R6848	T23254	T23255	advmod	potentially,indirect
R6849	T23255	T23256	amod	indirect,consequences
R6850	T23256	T23253	pobj	consequences,from
R6851	T23257	T23256	prep	of,consequences
R6852	T23258	T23259	amod	deregulated,division
R6853	T23259	T23257	pobj	division,of
R6854	T23260	T23259	cc	and,division
R6855	T23261	T23259	conj	death,division
R6856	T23262	T23243	punct	.,is
R6857	T23264	T23265	prep	In,is
R6858	T23266	T23267	det	any,case
R6859	T23267	T23264	pobj	case,In
R6860	T23268	T23265	punct	", ",is
R6861	T23269	T23265	nsubj	it,is
R6862	T23270	T23265	acomp	clear,is
R6863	T23271	T23272	mark	that,function
R6864	T23272	T23265	ccomp	function,is
R6865	T23273	T23272	prep	in,function
R6866	T23274	T23275	amod	most,cells
R6867	T23275	T23273	pobj	cells,in
R6868	T23276	T23275	amod	retinal,cells
R6869	T23277	T23275	punct	", ",cells
R6870	T23278	T23275	prep	including,cells
R6871	T23279	T23278	pobj	photoreceptors,including
R6872	T23280	T23281	punct	[,29
R6873	T23281	T23275	parataxis	29,cells
R6874	T23282	T23281	punct	],29
R6875	T23283	T23272	punct	", ",function
R6876	T23284	T23285	compound	transcription,factors
R6877	T23285	T23272	nsubj	factors,function
R6878	T23286	T23287	dep	that,promote
R6879	T23287	T23285	relcl	promote,factors
R6880	T23288	T23287	dobj	differentiation,promote
R6881	T23289	T23272	advmod	independently,function
R6882	T23290	T23289	prep	of,independently
R6883	T23291	T23290	pobj	Rb,of
R6884	T23292	T23265	punct	.,is
R6885	T23294	T23295	nsubj	We,found
R6886	T23296	T23295	aux	have,found
R6887	T23297	T23295	advmod	also,found
R6888	T23298	T23299	mark	that,rescues
R6889	T23299	T23295	ccomp	rescues,found
R6890	T23300	T23301	compound	E2f1,deletion
R6891	T23301	T23299	nsubj	deletion,rescues
R6892	T23302	T23303	npadvmod	cell,autonomous
R6893	T23303	T23305	amod	autonomous,division
R6894	T23304	T23303	punct	-,autonomous
R6895	T23305	T23299	dobj	division,rescues
R6896	T23306	T23305	amod	ectopic,division
R6897	T23307	T23305	punct	", ",division
R6898	T23308	T23305	conj	death,division
R6899	T23309	T23308	punct	", ",death
R6900	T23310	T23308	cc	and,death
R6901	T23311	T23312	compound	differentiation,defects
R6902	T23312	T23308	conj	defects,death
R6903	T23313	T23299	prep	in,rescues
R6904	T23314	T23315	amod	sporadic,clones
R6905	T23315	T23313	pobj	clones,in
R6906	T23316	T23317	compound	Rb,KO
R6907	T23317	T23315	compound	KO,clones
R6908	T23318	T23315	acl	generated,clones
R6909	T23319	T23318	advcl	using,generated
R6910	T23320	T23321	det	a,vector
R6911	T23321	T23319	dobj	vector,using
R6912	T23322	T23323	compound	Cre,retrovirus
R6913	T23323	T23321	compound	retrovirus,vector
R6914	T23324	T23325	punct	(,M.
R6915	T23325	T23319	meta	M.,using
R6916	T23326	T23325	nmod	P.,M.
R6917	T23327	T23325	cc	and,M.
R6918	T23328	T23325	conj	R.,M.
R6919	T23329	T23328	nmod	B.,R.
R6920	T23330	T23328	punct	", ",R.
R6921	T23331	T23332	amod	unpublished,data
R6922	T23332	T23328	conj	data,R.
R6923	T23333	T23332	punct	),data
R6924	T23334	T23295	punct	.,found
R6925	T23336	T23337	det	These,data
R6926	T23337	T23338	nsubj	data,are
R6927	T23339	T23338	acomp	consistent,are
R6928	T23340	T23339	prep	with,consistent
R6929	T23341	T23342	det	the,observation
R6930	T23342	T23340	pobj	observation,with
R6931	T23343	T23344	mark	that,drives
R6932	T23344	T23342	acl	drives,observation
R6933	T23345	T23346	compound	E2f1,overexpression
R6934	T23346	T23344	nsubj	overexpression,drives
R6935	T23347	T23346	prep	in,overexpression
R6936	T23348	T23349	amod	newborn,photoreceptors
R6937	T23349	T23347	pobj	photoreceptors,in
R6938	T23350	T23351	amod	ectopic,division
R6939	T23351	T23344	dobj	division,drives
R6940	T23352	T23351	cc	and,division
R6941	T23353	T23351	conj	apoptosis,division
R6942	T23354	T23355	punct	[,60
R6943	T23355	T23344	parataxis	60,drives
R6944	T23356	T23355	punct	],60
R6945	T23357	T23338	punct	", ",are
R6946	T23358	T23338	cc	and,are
R6947	T23359	T23338	conj	add,are
R6948	T23360	T23359	prep	to,add
R6949	T23361	T23362	det	the,evidence
R6950	T23362	T23360	pobj	evidence,to
R6951	T23363	T23362	amod	growing,evidence
R6952	T23364	T23362	acl	indicating,evidence
R6953	T23365	T23366	mark	that,is
R6954	T23366	T23364	ccomp	is,indicating
R6955	T23367	T23366	nsubj	E2f1,is
R6956	T23368	T23369	det	the,member
R6957	T23369	T23366	attr	member,is
R6958	T23370	T23369	amod	major,member
R6959	T23371	T23370	punct	", ",major
R6960	T23372	T23370	cc	and,major
R6961	T23373	T23374	advmod	perhaps,only
R6962	T23374	T23370	conj	only,major
R6963	T23375	T23369	punct	", ",member
R6964	T23376	T23369	prep	of,member
R6965	T23377	T23378	det	the,E2fs
R6966	T23378	T23376	pobj	E2fs,of
R6967	T23379	T23378	nummod	three,E2fs
R6968	T23380	T23378	amod	activating,E2fs
R6969	T23381	T23378	acl	required,E2fs
R6970	T23382	T23383	aux	to,induce
R6971	T23383	T23381	xcomp	induce,required
R6972	T23384	T23383	dobj	apoptosis,induce
R6973	T23385	T23383	prep	in,induce
R6974	T23386	T23387	compound	Rb,KO
R6975	T23387	T23388	compound	KO,cells
R6976	T23388	T23385	pobj	cells,in
R6977	T23389	T23390	punct	[,15
R6978	T23390	T23359	parataxis	15,add
R6979	T23391	T23390	nummod	10,15
R6980	T23392	T23390	punct	",",15
R6981	T23393	T23390	punct	],15
R6982	T23394	T23338	punct	.,are
R6983	T23396	T23397	advmod	Thus,promotes
R6984	T23398	T23397	punct	", ",promotes
R6985	T23399	T23400	amod	deregulated,activity
R6986	T23400	T23397	nsubj	activity,promotes
R6987	T23401	T23400	compound	E2f1,activity
R6988	T23402	T23400	prep	in,activity
R6989	T23403	T23404	det	the,retina
R6990	T23404	T23402	pobj	retina,in
R6991	T23405	T23397	punct	", ",promotes
R6992	T23406	T23407	mark	whether,resulting
R6993	T23407	T23397	advcl	resulting,promotes
R6994	T23408	T23407	prep	from,resulting
R6995	T23409	T23410	det	the,inactivation
R6996	T23410	T23408	pobj	inactivation,from
R6997	T23411	T23410	prep	of,inactivation
R6998	T23412	T23411	pobj	Rb,of
R6999	T23413	T23408	cc	or,from
R7000	T23414	T23408	conj	from,from
R7001	T23415	T23414	pobj	overexpression,from
R7002	T23416	T23397	punct	", ",promotes
R7003	T23417	T23418	amod	unscheduled,division
R7004	T23418	T23397	dobj	division,promotes
R7005	T23419	T23418	compound	cell,division
R7006	T23420	T23397	cc	and,promotes
R7007	T23421	T23397	conj	triggers,promotes
R7008	T23422	T23421	dobj	apoptosis,triggers
R7009	T23423	T23421	prep	in,triggers
R7010	T23424	T23425	amod	susceptible,RTCs
R7011	T23425	T23423	pobj	RTCs,in
R7012	T23426	T23397	punct	.,promotes
R7013	T23428	T23429	nsubj	E2f1,be
R7014	T23430	T23428	punct	", ",E2f1
R7015	T23431	T23432	advmod	rather,than
R7016	T23432	T23428	cc	than,E2f1
R7017	T23433	T23434	amod	other,E2fs
R7018	T23434	T23428	conj	E2fs,E2f1
R7019	T23435	T23429	punct	", ",be
R7020	T23436	T23429	aux	may,be
R7021	T23437	T23438	det	a,target
R7022	T23438	T23429	attr	target,be
R7023	T23439	T23438	amod	potential,target
R7024	T23440	T23438	prep	for,target
R7025	T23441	T23442	amod	novel,therapeutics
R7026	T23442	T23440	pobj	therapeutics,for
R7027	T23443	T23444	aux	to,prevent
R7028	T23444	T23442	advcl	prevent,therapeutics
R7029	T23445	T23444	dobj	retinoblastoma,prevent
R7030	T23446	T23444	prep	in,prevent
R7031	T23447	T23448	nmod	RB1,humans
R7032	T23448	T23446	pobj	humans,in
R7033	T23449	T23447	punct	+,RB1
R7034	T23450	T23447	punct	/,RB1
R7035	T23451	T23447	punct	−,RB1
R7036	T23452	T23429	punct	.,be
R7037	T23454	T23455	poss	Our,studies
R7038	T23455	T23457	nsubj	studies,revealed
R7039	T23456	T23455	compound	ERG,studies
R7040	T23458	T23457	dobj	rescue,revealed
R7041	T23459	T23458	prep	of,rescue
R7042	T23460	T23461	det	the,system
R7043	T23461	T23459	pobj	system,of
R7044	T23462	T23463	nmod	Rb,KO
R7045	T23463	T23461	nmod	KO,system
R7046	T23464	T23465	npadvmod	rod,bipolar
R7047	T23465	T23461	amod	bipolar,system
R7048	T23466	T23465	punct	–,bipolar
R7049	T23467	T23458	punct	", ",rescue
R7050	T23468	T23458	cc	and,rescue
R7051	T23469	T23470	advmod	almost,complete
R7052	T23470	T23471	amod	complete,restoration
R7053	T23471	T23458	conj	restoration,rescue
R7054	T23472	T23471	prep	of,restoration
R7055	T23473	T23474	det	the,system
R7056	T23474	T23472	pobj	system,of
R7057	T23475	T23476	npadvmod	cone,bipolar
R7058	T23476	T23474	amod	bipolar,system
R7059	T23477	T23476	punct	–,bipolar
R7060	T23478	T23458	prep	following,rescue
R7061	T23479	T23480	compound	E2f1,deletion
R7062	T23480	T23478	pobj	deletion,following
R7063	T23481	T23457	punct	.,revealed
R7064	T23483	T23484	expl	There,was
R7065	T23485	T23486	det	a,response
R7066	T23486	T23484	attr	response,was
R7067	T23487	T23488	advmod	slightly,lower
R7068	T23488	T23486	amod	lower,response
R7069	T23489	T23486	prep	in,response
R7070	T23490	T23491	det	the,retina
R7071	T23491	T23489	pobj	retina,in
R7072	T23492	T23493	compound	Rb,E2f1
R7073	T23493	T23495	compound	E2f1,DKO
R7074	T23494	T23493	punct	/,E2f1
R7075	T23495	T23491	compound	DKO,retina
R7076	T23496	T23484	advcl	relative,was
R7077	T23497	T23496	prep	to,relative
R7078	T23498	T23499	det	the,retina
R7079	T23499	T23497	pobj	retina,to
R7080	T23500	T23501	compound	E2f1,KO
R7081	T23501	T23499	compound	KO,retina
R7082	T23502	T23499	compound	control,retina
R7083	T23503	T23484	punct	.,was
R7084	T23505	T23506	det	This,difference
R7085	T23506	T23507	nsubj	difference,reflect
R7086	T23508	T23507	aux	might,reflect
R7087	T23509	T23510	det	a,role
R7088	T23510	T23507	dobj	role,reflect
R7089	T23511	T23510	prep	for,role
R7090	T23512	T23511	pobj	Rb,for
R7091	T23513	T23510	prep	in,role
R7092	T23514	T23515	det	the,development
R7093	T23515	T23513	pobj	development,in
R7094	T23516	T23515	prep	of,development
R7095	T23517	T23516	pobj	cones,of
R7096	T23518	T23517	punct	", ",cones
R7097	T23519	T23520	amod	bipolar,cells
R7098	T23520	T23517	conj	cells,cones
R7099	T23521	T23520	punct	", ",cells
R7100	T23522	T23520	cc	or,cells
R7101	T23523	T23524	amod	other,cells
R7102	T23524	T23520	conj	cells,cells
R7103	T23525	T23526	dep	that,contribute
R7104	T23526	T23524	relcl	contribute,cells
R7105	T23527	T23526	aux	may,contribute
R7106	T23528	T23526	prep	to,contribute
R7107	T23529	T23530	det	the,ERG
R7108	T23530	T23528	pobj	ERG,to
R7109	T23531	T23530	amod	photopic,ERG
R7110	T23532	T23524	punct	", ",cells
R7111	T23533	T23524	prep	including,cells
R7112	T23534	T23535	advmod	potentially,SACs
R7113	T23535	T23533	pobj	SACs,including
R7114	T23536	T23535	punct	", ",SACs
R7115	T23537	T23538	dep	which,have
R7116	T23538	T23535	relcl	have,SACs
R7117	T23539	T23538	aux	do,have
R7118	T23540	T23541	det	a,defect
R7119	T23541	T23538	dobj	defect,have
R7120	T23542	T23541	amod	serious,defect
R7121	T23543	T23541	prep	in,defect
R7122	T23544	T23545	det	the,retina
R7123	T23545	T23543	pobj	retina,in
R7124	T23546	T23547	compound	Rb,E2f1
R7125	T23547	T23549	compound	E2f1,DKO
R7126	T23548	T23547	punct	/,E2f1
R7127	T23549	T23545	compound	DKO,retina
R7128	T23550	T23507	punct	.,reflect
R7129	T24609	T24610	nsubj	Rb,Controls
R7130	T24611	T24612	compound	SAC,Differentiation
R7131	T24612	T24610	dobj	Differentiation,Controls
R7132	T24613	T24610	prep	through,Controls
R7133	T24614	T24613	pobj	E2f3a,through
R7134	T24616	T24617	amod	Comprehensive,analysis
R7135	T24617	T24619	nsubj	analysis,revealed
R7136	T24618	T24617	compound	marker,analysis
R7137	T24620	T24621	mark	that,suppress
R7138	T24621	T24619	ccomp	suppress,revealed
R7139	T24622	T24621	punct	", ",suppress
R7140	T24623	T24621	prep	in,suppress
R7141	T24624	T24625	amod	striking,contrast
R7142	T24625	T24623	pobj	contrast,in
R7143	T24626	T24625	prep	to,contrast
R7144	T24627	T24628	amod	other,neurons
R7145	T24628	T24626	pobj	neurons,to
R7146	T24629	T24628	amod	retinal,neurons
R7147	T24630	T24621	punct	", ",suppress
R7148	T24631	T24632	compound	E2f1,deletion
R7149	T24632	T24621	nsubj	deletion,suppress
R7150	T24633	T24621	aux	did,suppress
R7151	T24634	T24621	neg	not,suppress
R7152	T24635	T24621	dobj	defects,suppress
R7153	T24636	T24621	prep	in,suppress
R7154	T24637	T24638	nmod	Rb,KO
R7155	T24638	T24639	nmod	KO,SACs
R7156	T24639	T24636	pobj	SACs,in
R7157	T24640	T24639	amod	cholinergic,SACs
R7158	T24641	T24619	punct	.,revealed
R7159	T24643	T24644	advmod	Instead,observed
R7160	T24645	T24644	punct	", ",observed
R7161	T24646	T24644	nsubj	we,observed
R7162	T24647	T24648	npadvmod	E2f1,independent
R7163	T24648	T24650	amod	independent,defects
R7164	T24649	T24648	punct	-,independent
R7165	T24650	T24644	dobj	defects,observed
R7166	T24651	T24650	prep	in,defects
R7167	T24652	T24653	det	the,synthesis
R7168	T24653	T24651	pobj	synthesis,in
R7169	T24654	T24653	cc	and,synthesis
R7170	T24655	T24653	conj	transport,synthesis
R7171	T24656	T24653	prep	of,synthesis
R7172	T24657	T24658	det	a,cohort
R7173	T24658	T24656	pobj	cohort,of
R7174	T24659	T24658	amod	large,cohort
R7175	T24660	T24658	prep	of,cohort
R7176	T24661	T24662	compound	SAC,proteins
R7177	T24662	T24660	pobj	proteins,of
R7178	T24663	T24644	punct	.,observed
R7179	T24665	T24666	det	These,data
R7180	T24666	T24667	nsubj	data,expand
R7181	T24668	T24667	dobj	insight,expand
R7182	T24669	T24668	prep	into,insight
R7183	T24670	T24671	det	the,development
R7184	T24671	T24669	pobj	development,into
R7185	T24672	T24671	prep	of,development
R7186	T24673	T24674	det	these,interneurons
R7187	T24674	T24672	pobj	interneurons,of
R7188	T24675	T24674	amod	important,interneurons
R7189	T24676	T24667	punct	", ",expand
R7190	T24677	T24667	cc	but,expand
R7191	T24678	T24679	advmod	more,critically
R7192	T24679	T24680	advmod	critically,provide
R7193	T24680	T24667	conj	provide,expand
R7194	T24681	T24680	punct	", ",provide
R7195	T24682	T24680	prep	to,provide
R7196	T24683	T24684	poss	our,knowledge
R7197	T24684	T24682	pobj	knowledge,to
R7198	T24685	T24686	det	the,evidence
R7199	T24686	T24680	dobj	evidence,provide
R7200	T24687	T24686	amod	first,evidence
R7201	T24688	T24686	amod	unambiguous,evidence
R7202	T24689	T24690	mark	that,regulates
R7203	T24690	T24686	acl	regulates,evidence
R7204	T24691	T24690	nsubj	Rb,regulates
R7205	T24692	T24690	dobj	neurogenesis,regulates
R7206	T24693	T24690	prep	beyond,regulates
R7207	T24694	T24695	amod	terminal,mitosis
R7208	T24695	T24693	pobj	mitosis,beyond
R7209	T24696	T24667	punct	.,expand
R7210	T24698	T24699	nsubj	Rb,binds
R7211	T24700	T24701	amod	more,100
R7212	T24701	T24703	nummod	100,factors
R7213	T24702	T24701	quantmod	than,100
R7214	T24703	T24699	dobj	factors,binds
R7215	T24704	T24705	punct	[,43
R7216	T24705	T24699	parataxis	43,binds
R7217	T24706	T24705	punct	],43
R7218	T24707	T24699	punct	", ",binds
R7219	T24708	T24699	cc	and,binds
R7220	T24709	T24710	prep	in,binds
R7221	T24710	T24699	conj	binds,binds
R7222	T24711	T24712	amod	several,cells
R7223	T24712	T24709	pobj	cells,in
R7224	T24713	T24712	amod	non-neuronal,cells
R7225	T24714	T24712	punct	", ",cells
R7226	T24715	T24716	amod	such,as
R7227	T24716	T24712	prep	as,cells
R7228	T24717	T24718	amod	skeletal,muscle
R7229	T24718	T24716	pobj	muscle,as
R7230	T24719	T24718	punct	", ",muscle
R7231	T24720	T24718	conj	adipocytes,muscle
R7232	T24721	T24720	punct	", ",adipocytes
R7233	T24722	T24720	cc	and,adipocytes
R7234	T24723	T24720	conj	bone,adipocytes
R7235	T24724	T24710	punct	", ",binds
R7236	T24725	T24710	nsubj	it,binds
R7237	T24726	T24710	cc	and,binds
R7238	T24727	T24710	conj	potentiates,binds
R7239	T24728	T24729	npadvmod	tissue,specific
R7240	T24729	T24731	amod	specific,factors
R7241	T24730	T24729	punct	-,specific
R7242	T24731	T24727	dobj	factors,potentiates
R7243	T24732	T24731	compound	transcription,factors
R7244	T24733	T24734	dep	that,promote
R7245	T24734	T24731	relcl	promote,factors
R7246	T24735	T24734	dobj	differentiation,promote
R7247	T24736	T24737	punct	[,31
R7248	T24737	T24727	parataxis	31,potentiates
R7249	T24738	T24739	punct	–,33
R7250	T24739	T24737	prep	33,31
R7251	T24740	T24737	punct	],31
R7252	T24741	T24710	punct	.,binds
R7253	T24743	T24744	det	The,idea
R7254	T24744	T24745	nsubjpass	idea,contested
R7255	T24746	T24747	mark	that,promotes
R7256	T24747	T24744	acl	promotes,idea
R7257	T24748	T24747	nsubj	Rb,promotes
R7258	T24749	T24750	compound	muscle,differentiation
R7259	T24750	T24747	dobj	differentiation,promotes
R7260	T24751	T24747	prep	by,promotes
R7261	T24752	T24751	pcomp	potentiating,by
R7262	T24753	T24754	compound	Myod1,activity
R7263	T24754	T24752	dobj	activity,potentiating
R7264	T24755	T24745	auxpass	was,contested
R7265	T24756	T24757	punct	[,61
R7266	T24757	T24745	parataxis	61,contested
R7267	T24758	T24757	punct	],61
R7268	T24759	T24745	punct	", ",contested
R7269	T24760	T24745	cc	and,contested
R7270	T24761	T24762	amod	other,mechanisms
R7271	T24762	T24763	nsubj	mechanisms,proposed
R7307	T24822	T24821	pobj	E2f3,h
R7308	T24824	T24820	acomp	independent,was
R7309	T24825	T24824	prep	of,independent
R7310	T24826	T24827	poss	its,role
R7311	T24827	T24825	pobj	role,of
R7312	T24828	T24827	prep	in,role
R7313	T24829	T24828	pcomp	controlling,in
R7314	T24830	T24829	dobj	division,controlling
R7315	T24831	T24830	cc	or,division
R7316	T24832	T24830	conj	death,division
R7317	T24833	T24823	punct	: ,rescued
R7318	T24834	T24835	compound	E2f3,deletion
R7319	T24835	T24823	nsubj	deletion,rescued
R7320	T24836	T24837	compound	Rb,KO
R7321	T24837	T24838	compound	KO,defects
R7322	T24838	T24823	dobj	defects,rescued
R7323	T24839	T24838	compound	SAC,defects
R7324	T24840	T24823	cc	but,rescued
R7325	T24841	T24842	aux	did,suppress
R7326	T24842	T24823	conj	suppress,rescued
R7327	T24843	T24842	neg	not,suppress
R7328	T24844	T24845	amod	aberrant,proliferation
R7329	T24845	T24842	dobj	proliferation,suppress
R7330	T24846	T24845	cc	or,proliferation
R7331	T24847	T24845	conj	death,proliferation
R7332	T24848	T24842	punct	", ",suppress
R7333	T24849	T24850	mark	whereas,reversed
R7334	T24850	T24842	advcl	reversed,suppress
R7335	T24851	T24852	compound	E2f1,deletion
R7336	T24852	T24850	nsubj	deletion,reversed
R7337	T24853	T24854	amod	abnormal,proliferation
R7338	T24854	T24850	dobj	proliferation,reversed
R7339	T24855	T24854	cc	and,proliferation
R7340	T24856	T24854	conj	death,proliferation
R7341	T24857	T24850	cc	but,reversed
R7342	T24858	T24859	aux	did,rescue
R7343	T24859	T24850	conj	rescue,reversed
R7344	T24860	T24859	neg	not,rescue
R7345	T24861	T24862	compound	SAC,differentiation
R7346	T24862	T24859	dobj	differentiation,rescue
R7347	T24863	T24823	punct	.,rescued
R7348	T24865	T24866	amod	Double,labelling
R7349	T24866	T24867	nsubj	labelling,confirmed
R7350	T24868	T24869	mark	that,reversed
R7351	T24869	T24867	ccomp	reversed,confirmed
R7352	T24870	T24871	nmod	E2f1,deletion
R7353	T24871	T24869	nsubj	deletion,reversed
R7354	T24872	T24870	cc	but,E2f1
R7355	T24873	T24872	neg	not,but
R7356	T24874	T24870	conj	E2f3,E2f1
R7357	T24875	T24876	compound	Rb,KO
R7358	T24876	T24877	compound	KO,SAC
R7359	T24877	T24878	compound	SAC,division
R7360	T24878	T24869	dobj	division,reversed
R7361	T24879	T24867	punct	.,confirmed
R7362	T24881	T24882	advmod	Moreover,reversed
R7363	T24883	T24882	punct	", ",reversed
R7364	T24884	T24882	csubj	deleting,reversed
R7365	T24885	T24884	dobj	E2f1,deleting
R7366	T24886	T24885	punct	", ",E2f1
R7367	T24887	T24885	cc	but,E2f1
R7368	T24888	T24887	neg	not,but
R7369	T24889	T24885	conj	E2f3,E2f1
R7370	T24890	T24882	punct	", ",reversed
R7371	T24891	T24892	amod	deregulated,expression
R7372	T24892	T24882	dobj	expression,reversed
R7373	T24893	T24892	prep	of,expression
R7374	T24894	T24895	compound	cell,cycle
R7375	T24895	T24893	pobj	cycle,of
R7376	T24896	T24895	cc	and,cycle
R7377	T24897	T24898	amod	apoptotic,genes
R7378	T24898	T24895	conj	genes,cycle
R7379	T24899	T24882	prep	in,reversed
R7380	T24900	T24901	det	the,retina
R7381	T24901	T24899	pobj	retina,in
R7382	T24902	T24903	compound	Rb,KO
R7383	T24903	T24901	compound	KO,retina
R7384	T24904	T24882	punct	.,reversed
R7385	T24906	T24907	nsubjpass	E2f3,expressed
R7386	T24908	T24907	auxpass	is,expressed
R7387	T24909	T24907	prep	in,expressed
R7388	T24910	T24911	det	a,subset
R7389	T24911	T24909	pobj	subset,in
R7400	T24922	T24920	dobj	defects,drives
R7402	T24924	T24926	npadvmod	cycle,independent
R7403	T24925	T24924	punct	-,cycle
R7404	T24926	T24922	amod	independent,defects
R7405	T24927	T24926	punct	–,independent
R7406	T24928	T24920	prep	in,drives
R7407	T24929	T24930	compound	Rb,KO
R7408	T24930	T24931	compound	KO,neurons
R7409	T24931	T24928	pobj	neurons,in
R7410	T24932	T24931	compound	forebrain,neurons
R7411	T24933	T24934	punct	[,53
R7412	T24934	T24920	parataxis	53,drives
R7413	T24935	T24934	punct	],53
R7414	T24936	T24907	punct	.,expressed
R7415	T24938	T24939	advmod	Thus,is
R7416	T24940	T24939	punct	", ",is
R7417	T24941	T24942	compound	E2f3,inhibition
R7418	T24942	T24939	nsubj	inhibition,is
R7419	T24943	T24944	det	the,first
R7420	T24944	T24939	attr	first,is
R7421	T24945	T24939	punct	", ",is
R7422	T24946	T24939	cc	and,is
R7423	T24947	T24948	aux	may,be
R7424	T24948	T24939	conj	be,is
R7425	T24949	T24950	det	the,only
R7426	T24950	T24948	attr	only,be
R7427	T24951	T24948	punct	", ",be
R7428	T24952	T24948	conj	mechanism,be
R7429	T24953	T24954	prep	by,participates
R7430	T24954	T24952	ccomp	participates,mechanism
R7431	T24955	T24953	pobj	which,by
R7432	T24956	T24954	nsubj	Rb,participates
R7433	T24957	T24954	advmod	directly,participates
R7434	T24958	T24954	prep	in,participates
R7435	T24959	T24960	amod	neuronal,differentiation
R7436	T24960	T24958	pobj	differentiation,in
R7437	T24961	T24939	punct	.,is
R7438	T24963	T24964	aux	To,dissect
R7439	T24964	T24966	advcl	dissect,determined
R7440	T24965	T24964	advmod	further,dissect
R7441	T24967	T24968	det	the,mechanism
R7442	T24968	T24964	dobj	mechanism,dissect
R7443	T24969	T24968	prep	of,mechanism
R7444	T24970	T24969	pobj	action,of
R7445	T24971	T24968	prep	of,mechanism
R7446	T24972	T24971	pobj	Rb,of
R7447	T24973	T24968	prep	in,mechanism
R7448	T24974	T24973	pobj	SACs,in
R7449	T24975	T24966	nsubj	we,determined
R7450	T24976	T24977	det	the,isoform
R7451	T24977	T24966	dobj	isoform,determined
R7452	T24978	T24977	compound	E2f3,isoform
R7453	T24979	T24980	nsubj	it,targets
R7454	T24980	T24977	advcl	targets,isoform
R7455	T24981	T24982	aux	to,promote
R7456	T24982	T24980	advcl	promote,targets
R7457	T24983	T24982	dobj	differentiation,promote
R7458	T24984	T24966	punct	.,determined
R7459	T24986	T24987	nsubj	E2f3b,was
R7460	T24988	T24989	det	the,candidate
R7461	T24989	T24987	attr	candidate,was
R7462	T24990	T24989	amod	primary,candidate
R7463	T24991	T24987	punct	", ",was
R7464	T24992	T24993	mark	since,collaborate
R7465	T24993	T24987	advcl	collaborate,was
R7466	T24994	T24993	nsubj	Rb,collaborate
R7467	T24995	T24994	cc	and,Rb
R7468	T24996	T24994	conj	E2f3b,Rb
R7469	T24997	T24998	aux	to,repress
R7470	T24998	T24993	advcl	repress,collaborate
R7471	T24999	T24998	dobj	targets,repress
R7472	T25000	T24998	prep	in,repress
R7473	T25001	T25002	amod	quiescent,cells
R7474	T25002	T25000	pobj	cells,in
R7475	T25003	T25004	advmod	in,vitro
R7476	T25004	T24998	advmod	vitro,repress
R7477	T25005	T25006	punct	[,19
R7478	T25006	T24998	parataxis	19,repress
R7479	T25007	T25006	punct	],19
R7480	T25008	T24987	punct	.,was
R7481	T25010	T25011	advmod	However,made
R7482	T25012	T25011	punct	", ",made
R7483	T25013	T25011	prep	in,made
R7484	T25014	T25015	det	the,work
R7485	T25015	T25013	pobj	work,in
R7486	T25016	T25015	amod	first,work
R7487	T25017	T25018	prep	to,examine
R7488	T25018	T25015	advcl	examine,work
R7489	T25019	T25020	poss	our,knowledge
R7490	T25020	T25017	pobj	knowledge,to
R7491	T25021	T25018	aux	to,examine
R7492	T25022	T25023	det	the,function
R7493	T25023	T25018	dobj	function,examine
R7494	T25024	T25023	prep	of,function
R7495	T25025	T25026	det	any,isoform
R7496	T25026	T25024	pobj	isoform,of
R7497	T25027	T25028	compound	E2f,protein
R7498	T25028	T25026	compound	protein,isoform
R7499	T25029	T25030	advmod	in,vivo
R7500	T25030	T25018	advmod	vivo,examine
R7501	T25031	T25011	punct	", ",made
R7502	T25032	T25011	nsubj	we,made
R7503	T25033	T25034	det	the,observation
R7504	T25034	T25011	dobj	observation,made
R7505	T25035	T25034	amod	surprising,observation
R7506	T25036	T25037	mark	that,regulates
R7507	T25037	T25034	acl	regulates,observation
R7508	T25038	T25037	nsubj	Rb,regulates
R7509	T25039	T25040	compound	SAC,differentiation
R7510	T25040	T25037	dobj	differentiation,regulates
R7511	T25041	T25037	prep	through,regulates
R7512	T25042	T25041	pobj	E2f3a,through
R7513	T25043	T25044	punct	(,Figure
R7514	T25044	T25037	parataxis	Figure,regulates
R7515	T25045	T25044	nummod	8,Figure
R7516	T25046	T25044	punct	),Figure
R7517	T25047	T25011	punct	.,made
R7518	T25049	T25050	advmod	Formally,exclude
R7519	T25051	T25050	punct	", ",exclude
R7520	T25052	T25050	nsubj	we,exclude
R7521	T25053	T25050	aux	can,exclude
R7522	T25054	T25050	neg	not,exclude
R7523	T25055	T25056	det	the,possibility
R7524	T25056	T25050	dobj	possibility,exclude
R7525	T25057	T25058	mark	that,rescue
R7526	T25058	T25056	acl	rescue,possibility
R7527	T25059	T25058	csubj	deleting,rescue
R7528	T25060	T25059	dobj	E2f3b,deleting
R7529	T25061	T25058	aux	might,rescue
R7530	T25062	T25058	advmod	also,rescue
R7531	T25063	T25064	compound	SAC,differentiation
R7532	T25064	T25058	dobj	differentiation,rescue
R7533	T25065	T25050	punct	", ",exclude
R7534	T25066	T25050	cc	but,exclude
R7535	T25067	T25068	amod	definitive,proof
R7536	T25068	T25069	nsubj	proof,require
R7537	T25069	T25050	conj	require,exclude
R7538	T25070	T25069	aux	will,require
R7539	T25071	T25069	dobj	analysis,require
R7540	T25072	T25071	prep	of,analysis
R7541	T25073	T25074	npadvmod	E2f3b,null
R7542	T25074	T25075	amod	null,mice
R7543	T25075	T25072	pobj	mice,of
R7544	T25076	T25069	punct	.,require
R7545	T25078	T25079	advmod	Nevertheless,prove
R7546	T25080	T25079	punct	", ",prove
R7547	T25081	T25082	poss	our,data
R7548	T25082	T25079	nsubj	data,prove
R7549	T25083	T25084	mark	that,regulates
R7550	T25084	T25079	ccomp	regulates,prove
R7551	T25085	T25084	nsubj	Rb,regulates
R7552	T25086	T25084	advmod	definitely,regulates
R7553	T25087	T25088	compound	SAC,differentiation
R7554	T25088	T25084	dobj	differentiation,regulates
R7555	T25089	T25084	prep	through,regulates
R7556	T25090	T25091	det	the,isoform
R7557	T25091	T25089	pobj	isoform,through
R7558	T25092	T25091	amod	activating,isoform
R7559	T25093	T25091	compound	E2f3,isoform
R7560	T25094	T25079	punct	.,prove
R7561	T25716	T25717	amod	Distinct,Localization
R7562	T25718	T25717	nmod	E2f3a,Localization
R7563	T25719	T25718	cc	and,E2f3a
R7564	T25720	T25718	conj	E2f3b,E2f3a
R7565	T25722	T25723	det	The,location
R7566	T25723	T25725	nsubjpass	location,addressed
R7567	T25724	T25723	amod	subcellular,location
R7568	T25726	T25723	prep	of,location
R7569	T25727	T25728	compound	E2f,isoforms
R7570	T25728	T25726	pobj	isoforms,of
R7571	T25729	T25725	aux	has,addressed
R7572	T25730	T25725	neg	not,addressed
R7573	T25731	T25725	prep	to,addressed
R7574	T25732	T25733	poss	our,knowledge
R7575	T25733	T25731	pobj	knowledge,to
R7576	T25734	T25725	auxpass	been,addressed
R7577	T25735	T25725	advmod	before,addressed
R7578	T25736	T25725	punct	.,addressed
R7579	T25738	T25739	nsubj	E2f3a,share
R7580	T25740	T25738	cc	and,E2f3a
R7581	T25741	T25738	conj	E2f3b,E2f3a
R7582	T25742	T25743	nummod	110,acids
R7583	T25743	T25739	dobj	acids,share
R7584	T25744	T25745	npadvmod	C,terminal
R7585	T25745	T25743	amod	terminal,acids
R7586	T25746	T25745	punct	-,terminal
R7587	T25747	T25743	compound	amino,acids
R7588	T25748	T25749	dep	that,encode
R7589	T25749	T25743	relcl	encode,acids
R7590	T25750	T25751	det	the,domains
R7591	T25751	T25749	dobj	domains,encode
R7592	T25752	T25751	nmod	NLS,domains
R7593	T25753	T25752	punct	", ",NLS
R7594	T25754	T25752	conj	DNA,NLS
R7595	T25755	T25754	punct	-,DNA
R7596	T25756	T25754	amod	binding,DNA
R7597	T25757	T25754	punct	", ",DNA
R7598	T25758	T25759	amod	marked,box
R7599	T25759	T25754	conj	box,DNA
R7600	T25760	T25759	punct	", ",box
R7601	T25761	T25759	conj	transactivation,box
R7602	T25762	T25761	punct	", ",transactivation
R7603	T25763	T25761	cc	and,transactivation
R7604	T25764	T25761	conj	Rb,transactivation
R7605	T25765	T25764	punct	-,Rb
R7606	T25766	T25764	amod	binding,Rb
R7607	T25767	T25768	punct	[,16
R7608	T25768	T25739	parataxis	16,share
R7609	T25769	T25768	punct	],16
R7610	T25770	T25739	punct	", ",share
R7611	T25771	T25739	cc	yet,share
R7612	T25772	T25773	nsubj	they,exhibit
R7613	T25773	T25739	conj	exhibit,share
R7614	T25774	T25775	amod	different,distribution
R7615	T25775	T25773	dobj	distribution,exhibit
R7616	T25776	T25775	amod	subcellular,distribution
R7617	T25777	T25773	prep	in,exhibit
R7618	T25778	T25779	amod	developing,cells
R7619	T25779	T25777	pobj	cells,in
R7620	T25780	T25779	amod	retinal,cells
R7621	T25781	T25773	punct	.,exhibit
R7622	T25783	T25784	nsubj	E2f3a,is
R7623	T25785	T25786	preconj	both,nuclear
R7624	T25786	T25784	acomp	nuclear,is
R7625	T25787	T25786	cc	and,nuclear
R7626	T25788	T25786	conj	cytoplasmic,nuclear
R7627	T25789	T25784	punct	", ",is
R7628	T25790	T25784	cc	but,is
R7629	T25791	T25792	nsubj	E2f3b,is
R7630	T25792	T25784	conj	is,is
R7631	T25793	T25792	advmod	always,is
R7632	T25794	T25792	acomp	nuclear,is
R7633	T25795	T25792	punct	.,is
R7634	T25797	T25798	det	The,termini
R7635	T25798	T25808	nsubj	termini,mediate
R7636	T25799	T25798	amod	unique,termini
R7637	T25800	T25801	nummod	121,residue
R7638	T25801	T25798	compound	residue,termini
R7639	T25802	T25800	punct	-,121
R7640	T25803	T25800	cc	and,121
R7641	T25804	T25800	conj	six,121
R7642	T25805	T25801	punct	-,residue
R7643	T25806	T25798	compound	N,termini
R7644	T25807	T25798	punct	-,termini
R7645	T25809	T25798	prep	of,termini
R7646	T25810	T25809	pobj	E2f3a,of
R7647	T25811	T25810	cc	and,E2f3a
R7648	T25812	T25810	conj	E2f3b,E2f3a
R7649	T25813	T25808	punct	", ",mediate
R7650	T25814	T25808	advmod	respectively,mediate
R7651	T25815	T25808	punct	", ",mediate
R7652	T25816	T25808	advmod	likely,mediate
R7653	T25817	T25818	det	this,difference
R7654	T25818	T25808	dobj	difference,mediate
R7655	T25819	T25808	punct	.,mediate
R7656	T25821	T25822	det	This,region
R7657	T25822	T25823	nsubj	region,binds
R7658	T25824	T25822	prep	in,region
R7659	T25825	T25824	pobj	E2f1,in
R7660	T25826	T25825	punct	", ",E2f1
R7661	T25827	T25825	conj	E2f2,E2f1
R7662	T25828	T25827	punct	", ",E2f2
R7663	T25829	T25827	cc	and,E2f2
R7664	T25830	T25827	conj	E2f3a,E2f2
R7665	T25831	T25823	dobj	Ccna2,binds
R7666	T25832	T25823	punct	", ",binds
R7667	T25833	T25823	advcl	establishing,binds
R7668	T25834	T25835	det	a,loop
R7669	T25835	T25833	dobj	loop,establishing
R7670	T25836	T25835	amod	negative,loop
R7671	T25837	T25835	amod	regulatory,loop
R7672	T25838	T25839	dep	that,deactivates
R7673	T25839	T25835	relcl	deactivates,loop
R7674	T25840	T25839	dobj	E2fs,deactivates
R7675	T25841	T25839	prep	in,deactivates
R7676	T25842	T25843	amod	mid,late
R7677	T25843	T25845	amod	late,phase
R7678	T25844	T25843	punct	-,late
R7679	T25845	T25841	pobj	phase,in
R7680	T25846	T25845	compound	S,phase
R7681	T25847	T25845	punct	-,phase
R7682	T25848	T25849	punct	[,65
R7683	T25849	T25833	parataxis	65,establishing
R7684	T25850	T25849	nummod	64,65
R7685	T25851	T25849	punct	",",65
R7686	T25852	T25849	punct	],65
R7687	T25853	T25823	punct	.,binds
R7688	T25855	T25856	advmod	However,binds
R7689	T25857	T25856	punct	", ",binds
R7690	T25858	T25859	advmod	even,E2f3b
R7691	T25859	T25856	nsubj	E2f3b,binds
R7692	T25860	T25859	punct	", ",E2f3b
R7693	T25861	T25862	dep	which,lacks
R7694	T25862	T25859	relcl	lacks,E2f3b
R7695	T25863	T25864	det	this,domain
R7696	T25864	T25862	dobj	domain,lacks
R7697	T25865	T25856	punct	", ",binds
R7698	T25866	T25856	cc	and,binds
R7699	T25867	T25868	auxpass	is,regulated
R7700	T25868	T25856	conj	regulated,binds
R7701	T25869	T25868	agent	by,regulated
R7702	T25870	T25868	dobj	Ccna2,regulated
R7703	T25871	T25872	punct	[,18
R7704	T25872	T25870	parataxis	18,Ccna2
R7705	T25873	T25872	punct	],18
R7706	T25874	T25856	punct	", ",binds
R7707	T25875	T25876	mark	so,explain
R7708	T25876	T25856	advcl	explain,binds
R7709	T25877	T25878	det	the,difference
R7710	T25878	T25876	nsubj	difference,explain
R7711	T25879	T25878	compound	domain,difference
R7712	T25880	T25876	aux	may,explain
R7713	T25881	T25876	neg	not,explain
R7714	T25882	T25883	det	the,distributions
R7715	T25883	T25876	dobj	distributions,explain
R7716	T25884	T25883	amod	unique,distributions
R7717	T25885	T25886	nsubj	we,observed
R7718	T25886	T25883	advcl	observed,distributions
R7719	T25887	T25856	punct	.,binds
R7720	T25889	T25890	nmod	Rb,family
R7721	T25890	T25891	nmod	family,proteins
R7722	T25891	T25894	nsubj	proteins,determine
R7723	T25892	T25890	cc	and,family
R7724	T25893	T25890	conj	Tfdp,family
R7725	T25895	T25894	aux	can,determine
R7726	T25896	T25894	advmod	also,determine
R7727	T25897	T25898	compound	E2f,localization
R7728	T25898	T25894	dobj	localization,determine
R7729	T25899	T25900	punct	[,20
R7730	T25900	T25894	parataxis	20,determine
R7731	T25901	T25902	punct	–,22
R7732	T25902	T25900	prep	22,20
R7733	T25903	T25900	punct	],20
R7734	T25904	T25894	punct	", ",determine
R7735	T25905	T25894	cc	and,determine
R7736	T25906	T25907	nsubj	we,found
R7737	T25907	T25894	conj	found,determine
R7738	T25908	T25909	mark	that,are
R7739	T25909	T25907	ccomp	are,found
R7740	T25910	T25911	det	a,portion
R7741	T25911	T25909	nsubj	portion,are
R7742	T25912	T25911	prep	of,portion
R7743	T25913	T25914	preconj	both,Rb
R7744	T25914	T25915	nmod	Rb,proteins
R7745	T25915	T25912	pobj	proteins,of
R7746	T25916	T25914	cc	and,Rb
R7747	T25917	T25914	conj	Tfdp1,Rb
R7748	T25918	T25909	acomp	cytoplasmic,are
R7749	T25919	T25909	prep	in,are
R7750	T25920	T25921	amod	retinal,cells
R7751	T25921	T25919	pobj	cells,in
R7752	T25922	T25907	punct	.,found
R7753	T25924	T25925	advmod	Indeed,revealed
R7754	T25926	T25925	punct	", ",revealed
R7755	T25927	T25925	nsubj	immunostaining,revealed
R7756	T25928	T25929	mark	that,colocalize
R7757	T25929	T25925	ccomp	colocalize,revealed
R7758	T25930	T25929	nsubj	Rb,colocalize
R7759	T25931	T25930	cc	and,Rb
R7760	T25932	T25930	conj	E2f3,Rb
R7761	T25933	T25929	prep	to,colocalize
R7762	T25934	T25935	compound	SAC,processes
R7763	T25935	T25933	pobj	processes,to
R7764	T25936	T25925	punct	.,revealed
R7765	T25938	T25939	det	The,localization
R7766	T25939	T25941	nsubj	localization,contrasts
R7767	T25940	T25939	amod	nuclear,localization
R7768	T25942	T25939	prep	of,localization
R7769	T25943	T25942	pobj	E2f3b,of
R7770	T25944	T25941	prep	with,contrasts
R7771	T25945	T25944	pobj	that,with
R7772	T25946	T25945	prep	of,that
R7773	T25947	T25948	amod	other,E2fs
R7774	T25948	T25946	pobj	E2fs,of
R7775	T25949	T25948	amod	repressive,E2fs
R7776	T25950	T25948	prep	in,E2fs
R7777	T25951	T25952	amod	differentiating,muscle
R7778	T25952	T25950	pobj	muscle,in
R7779	T25953	T25952	punct	", ",muscle
R7780	T25954	T25955	advmod	where,switches
R7781	T25955	T25952	relcl	switches,muscle
R7782	T25956	T25955	nsubj	E2f5,switches
R7783	T25957	T25955	prep	from,switches
R7784	T25958	T25959	det	the,nucleus
R7785	T25959	T25957	pobj	nucleus,from
R7786	T25960	T25957	prep	to,from
R7787	T25961	T25960	pobj	cytoplasm,to
R7788	T25962	T25941	punct	", ",contrasts
R7789	T25963	T25964	mark	while,remains
R7790	T25964	T25941	advcl	remains,contrasts
R7791	T25965	T25964	nsubj	E2f4,remains
R7792	T25966	T25964	prep	in,remains
R7793	T25967	T25968	det	both,compartments
R7794	T25968	T25966	pobj	compartments,in
R7795	T25969	T25970	punct	[,23
R7796	T25970	T25964	parataxis	23,remains
R7797	T25971	T25970	punct	],23
R7798	T25972	T25941	punct	.,contrasts
R7799	T25974	T25975	det	The,compartmentalization
R7800	T25975	T25977	nsubj	compartmentalization,suggests
R7801	T25976	T25975	amod	distinct,compartmentalization
R7802	T25978	T25975	prep	of,compartmentalization
R7803	T25979	T25978	pobj	E2f3a,of
R7804	T25980	T25979	cc	and,E2f3a
R7805	T25981	T25979	conj	E2f3b,E2f3a
R7806	T25982	T25975	prep	in,compartmentalization
R7807	T25983	T25984	det	the,retina
R7808	T25984	T25982	pobj	retina,in
R7809	T25985	T25986	advmod	temporally,distinct
R7810	T25986	T25989	amod	distinct,activities
R7811	T25987	T25985	cc	and,temporally
R7812	T25988	T25985	conj	functionally,temporally
R7813	T25989	T25977	dobj	activities,suggests
R7814	T25990	T25977	punct	.,suggests
R7815	T25992	T25993	compound	Rb,distribution
R7816	T25993	T25994	nsubj	distribution,matches
R7817	T25995	T25994	dobj	that,matches
R7818	T25996	T25995	prep	of,that
R7819	T25997	T25996	pobj	E2f3a,of
R7820	T25998	T25994	punct	", ",matches
R7821	T25999	T25994	advcl	consistent,matches
R7822	T26000	T25999	prep	with,consistent
R7823	T26001	T26002	poss	its,role
R7824	T26002	T26000	pobj	role,with
R7825	T26003	T26002	amod	critical,role
R7826	T26004	T26002	prep	in,role
R7827	T26005	T26004	pcomp	supporting,in
R7828	T26006	T26007	compound	SAC,differentiation
R7829	T26007	T26005	dobj	differentiation,supporting
R7830	T26008	T26005	prep	through,supporting
R7831	T26009	T26008	pobj	E2f3a,through
R7832	T26010	T25994	punct	.,matches
R7837	T26609	T26610	amod	Ectopic,Division
R7838	T26611	T26610	cc	and,Division
R7839	T26612	T26610	conj	Differentiation,Division
R7840	T26614	T26615	nsubj	Rb,is
R7841	T26616	T26615	acomp	critical,is
R7842	T26617	T26618	aux	to,ensure
R7843	T26618	T26616	xcomp	ensure,critical
R7844	T26619	T26620	mark	that,leave
R7845	T26620	T26618	ccomp	leave,ensure
R7846	T26621	T26622	amod	many,types
R7847	T26622	T26620	nsubj	types,leave
R7848	T26623	T26622	prep	of,types
R7849	T26624	T26625	advmod	terminally,differentiating
R7850	T26625	T26626	amod	differentiating,cells
R7851	T26626	T26623	pobj	cells,of
R7852	T26627	T26628	det	the,cycle
R7853	T26628	T26620	dative	cycle,leave
R7854	T26629	T26628	compound	cell,cycle
R7855	T26630	T26620	punct	(,leave
R7856	T26631	T26632	advmod	e.g.,neurons
R7857	T26632	T26620	dobj	neurons,leave
R7858	T26633	T26632	punct	", ",neurons
R7859	T26634	T26632	punct	", ",neurons
R7860	T26635	T26636	nmod	gut,epithelia
R7861	T26636	T26632	conj	epithelia,neurons
R7862	T26637	T26635	cc	and,gut
R7863	T26638	T26635	conj	skin,gut
R7864	T26639	T26636	punct	", ",epithelia
R7865	T26640	T26636	conj	muscle,epithelia
R7866	T26641	T26640	punct	", ",muscle
R7867	T26642	T26640	cc	and,muscle
R7868	T26643	T26644	compound	lens,fibres
R7869	T26644	T26640	conj	fibres,muscle
R7870	T26645	T26620	punct	),leave
R7871	T26646	T26647	punct	(,reviewed
R7872	T26647	T26620	parataxis	reviewed,leave
R7873	T26648	T26647	prep	in,reviewed
R7874	T26649	T26648	punct	[,in
R7875	T26650	T26648	pobj	66,in
R7876	T26651	T26647	punct	],reviewed
R7877	T26652	T26647	punct	),reviewed
R7878	T26653	T26615	punct	.,is
R7879	T26655	T26656	amod	Early,studies
R7880	T26656	T26658	nsubj	studies,suggested
R7881	T26657	T26656	compound	overexpression,studies
R7882	T26659	T26660	advmod	in,vitro
R7883	T26660	T26656	advmod	vitro,studies
R7884	T26661	T26662	nsubj	Rb,temper
R7885	T26662	T26658	advcl	temper,suggested
R7886	T26663	T26662	aux	might,temper
R7887	T26664	T26662	dobj	expansion,temper
R7888	T26665	T26664	prep	of,expansion
R7889	T26666	T26667	compound	cycling,cells
R7890	T26667	T26665	pobj	cells,of
R7891	T26668	T26658	punct	", ",suggested
R7892	T26669	T26658	cc	but,suggested
R7893	T26670	T26671	compound	KO,studies
R7894	T26671	T26672	nsubj	studies,indicate
R7895	T26672	T26658	conj	indicate,suggested
R7896	T26673	T26674	advmod	in,vivo
R7897	T26674	T26671	advmod	vivo,studies
R7898	T26675	T26676	mark	that,is
R7899	T26676	T26672	ccomp	is,indicate
R7900	T26677	T26678	poss	its,role
R7901	T26678	T26676	nsubj	role,is
R7902	T26679	T26678	amod	major,role
R7903	T26680	T26681	aux	to,block
R7904	T26681	T26676	xcomp	block,is
R7905	T26682	T26681	dobj	division,block
R7906	T26683	T26681	prep	in,block
R7907	T26684	T26685	advmod	terminally,differentiating
R7908	T26685	T26686	amod	differentiating,cells
R7909	T26686	T26683	pobj	cells,in
R7910	T26687	T26672	punct	.,indicate
R7911	T26689	T26690	prep	In,go
R7912	T26691	T26692	poss	its,absence
R7913	T26692	T26689	pobj	absence,In
R7914	T26693	T26690	punct	", ",go
R7915	T26694	T26690	nsubj	many,go
R7916	T26695	T26694	punct	(,many
R7917	T26696	T26694	cc	but,many
R7918	T26697	T26696	advmod	clearly,but
R7919	T26698	T26696	neg	not,but
R7920	T26699	T26700	nmod	all,aspects
R7921	T26700	T26694	conj	aspects,many
R7922	T26701	T26700	punct	),aspects
R7923	T26702	T26694	prep	of,many
R7924	T26703	T26702	pobj	differentiation,of
R7925	T26704	T26690	prt	ahead,go
R7926	T26705	T26706	advmod	relatively,unperturbed
R7927	T26706	T26690	advcl	unperturbed,go
R7928	T26707	T26690	punct	.,go
R7929	T26709	T26710	prep	In,born
R7930	T26711	T26712	det	the,retina
R7931	T26712	T26709	pobj	retina,In
R7932	T26713	T26710	punct	", ",born
R7933	T26714	T26715	amod	differentiating,cells
R7934	T26715	T26710	nsubjpass	cells,born
R7935	T26716	T26715	compound	transition,cells
R7936	T26717	T26710	auxpass	are,born
R7937	T26718	T26710	prep	in,born
R7938	T26719	T26720	det	the,absence
R7939	T26720	T26718	pobj	absence,in
R7940	T26721	T26720	prep	of,absence
R7941	T26722	T26721	pobj	Rb,of
R7942	T26723	T26710	punct	", ",born
R7943	T26724	T26710	conj	migrate,born
R7944	T26725	T26724	prep	to,migrate
R7945	T26726	T26727	det	the,layer
R7946	T26727	T26725	pobj	layer,to
R7947	T26728	T26727	amod	correct,layer
R7948	T26729	T26724	punct	", ",migrate
R7949	T26730	T26724	cc	and,migrate
R7950	T26731	T26724	conj	express,migrate
R7951	T26732	T26733	amod	appropriate,markers
R7952	T26733	T26731	dobj	markers,express
R7953	T26734	T26735	punct	(,2
R7954	T26735	T26731	parataxis	2,express
R7955	T26736	T26735	punct	[,2
R7956	T26737	T26735	punct	],2
R7957	T26738	T26735	cc	and,2
R7958	T26739	T26740	det	this,work
R7959	T26740	T26735	conj	work,2
R7960	T26741	T26740	punct	),work
R7961	T26742	T26710	punct	.,born
R7962	T26744	T26745	prep	In,migrate
R7963	T26746	T26744	pobj	brain,In
R7964	T26747	T26745	punct	", ",migrate
R7965	T26748	T26749	compound	Rb,KO
R7966	T26749	T26750	compound	KO,neurons
R7967	T26750	T26745	nsubj	neurons,migrate
R7968	T26751	T26745	advmod	away,migrate
R7969	T26752	T26751	prep	from,away
R7970	T26753	T26754	det	the,zone
R7971	T26754	T26752	pobj	zone,from
R7972	T26755	T26754	amod	ventricular,zone
R7973	T26756	T26745	cc	and,migrate
R7974	T26757	T26745	conj	switch,migrate
R7975	T26758	T26757	prt	on,switch
R7976	T26759	T26757	dobj	Tubb3,switch
R7977	T26760	T26759	punct	(,Tubb3
R7978	T26761	T26762	compound	βIII,tubulin
R7979	T26762	T26759	appos	tubulin,Tubb3
R7980	T26763	T26762	punct	-,tubulin
R7981	T26764	T26757	punct	),switch
R7982	T26765	T26757	punct	", ",switch
R7983	T26766	T26757	cc	but,switch
R7984	T26767	T26757	conj	continue,switch
R7985	T26768	T26769	aux	to,incorporate
R7986	T26769	T26767	xcomp	incorporate,continue
R7987	T26770	T26769	dobj	BrdU,incorporate
R7988	T26771	T26772	punct	[,13
R7989	T26772	T26769	parataxis	13,incorporate
R7990	T26773	T26772	punct	],13
R7991	T26774	T26745	punct	", ",migrate
R7992	T26775	T26745	cc	and,migrate
R7993	T26776	T26777	prep	in,migrate
R7994	T26777	T26745	conj	migrate,migrate
R7995	T26778	T26779	compound	gut,epithelia
R7996	T26779	T26776	pobj	epithelia,in
R7997	T26780	T26777	punct	", ",migrate
R7998	T26781	T26782	amod	differentiated,enterocytes
R7999	T26782	T26777	nsubj	enterocytes,migrate
R8000	T26783	T26777	prep	up,migrate
R8001	T26784	T26785	det	the,villi
R8002	T26785	T26783	pobj	villi,up
R8003	T26786	T26777	cc	and,migrate
R8004	T26787	T26777	conj	activate,migrate
R8005	T26788	T26787	dobj	expression,activate
R8006	T26789	T26788	prep	of,expression
R8007	T26790	T26789	pobj	serotonin,of
R8008	T26791	T26787	punct	", ",activate
R8009	T26792	T26787	cc	yet,activate
R8010	T26793	T26787	conj	continue,activate
R8011	T26794	T26795	aux	to,incorporate
R8012	T26795	T26793	xcomp	incorporate,continue
R8013	T26796	T26795	dobj	BrdU,incorporate
R8014	T26797	T26798	punct	[,67
R8015	T26798	T26795	parataxis	67,incorporate
R8016	T26799	T26798	punct	],67
R8017	T26800	T26777	punct	.,migrate
R8018	T26802	T26803	prep	In,were
R8019	T26804	T26805	det	the,case
R8020	T26805	T26802	pobj	case,In
R8021	T26806	T26805	prep	of,case
R8022	T26807	T26806	pobj	SACs,of
R8023	T26808	T26803	punct	", ",were
R8024	T26809	T26810	det	the,differentiation
R8025	T26810	T26803	nsubj	differentiation,were
R8026	T26811	T26810	nmod	defects,differentiation
R8027	T26812	T26813	nsubj	we,observed
R8028	T26813	T26810	advcl	observed,differentiation
R8029	T26814	T26810	punct	(,differentiation
R8030	T26815	T26816	advmod	e.g.,loss
R8031	T26816	T26810	appos	loss,differentiation
R8032	T26817	T26816	punct	", ",loss
R8033	T26818	T26816	prep	of,loss
R8034	T26819	T26818	pobj	Slc18a3,of
R8035	T26820	T26819	cc	and,Slc18a3
R8036	T26821	T26819	conj	Chat,Slc18a3
R8037	T26822	T26803	punct	),were
R8038	T26823	T26803	neg	not,were
R8039	T26824	T26803	prep	due,were
R8040	T26825	T26824	pcomp	to,due
R8041	T26826	T26827	amod	aberrant,division
R8042	T26827	T26824	pobj	division,due
R8043	T26828	T26803	punct	", ",were
R8044	T26829	T26803	cc	but,were
R8045	T26830	T26831	nsubj	it,is
R8046	T26831	T26803	conj	is,were
R8047	T26832	T26831	acomp	possible,is
R8048	T26833	T26834	expl	there,are
R8049	T26834	T26831	advcl	are,is
R8050	T26835	T26836	amod	other,problems
R8051	T26836	T26834	attr	problems,are
R8052	T26837	T26836	prep	with,problems
R8053	T26838	T26839	det	these,cells
R8054	T26839	T26837	pobj	cells,with
R8055	T26840	T26841	dep	that,caused
R8056	T26841	T26836	relcl	caused,problems
R8057	T26842	T26841	auxpass	are,caused
R8058	T26843	T26841	agent	by,caused
R8059	T26844	T26845	amod	ectopic,division
R8060	T26845	T26843	pobj	division,by
R8061	T26846	T26831	punct	.,is
R8062	T26848	T26849	advmod	Nevertheless,is
R8063	T26850	T26849	punct	", ",is
R8064	T26851	T26849	nsubj	it,is
R8065	T26852	T26849	acomp	clear,is
R8066	T26853	T26854	mark	that,are
R8067	T26854	T26849	ccomp	are,is
R8068	T26855	T26856	amod	many,aspects
R8069	T26856	T26854	nsubj	aspects,are
R8070	T26857	T26856	prep	of,aspects
R8071	T26858	T26857	pobj	differentiation,of
R8072	T26859	T26856	prep	in,aspects
R8073	T26860	T26861	amod	multiple,types
R8074	T26861	T26859	pobj	types,in
R8075	T26862	T26861	compound	cell,types
R8076	T26863	T26854	acomp	compatible,are
R8077	T26864	T26863	prep	with,compatible
R8078	T26865	T26866	amod	ectopic,division
R8079	T26866	T26864	pobj	division,with
R8080	T26867	T26849	punct	.,is
R8081	T26869	T26870	advmod	However,is
R8082	T26871	T26870	punct	", ",is
R8083	T26872	T26870	nsubj	division,is
R8084	T26873	T26872	prep	of,division
R8085	T26874	T26875	advmod	terminally,differentiating
R8086	T26875	T26876	amod	differentiating,cells
R8087	T26876	T26873	pobj	cells,of
R8088	T26877	T26870	acomp	dangerous,is
R8089	T26878	T26870	punct	", ",is
R8090	T26879	T26880	mark	since,facilitate
R8091	T26880	T26870	advcl	facilitate,is
R8092	T26881	T26880	nsubj	it,facilitate
R8093	T26882	T26880	aux	may,facilitate
R8094	T26883	T26880	dobj	transformation,facilitate
R8095	T26884	T26880	punct	", ",facilitate
R8096	T26885	T26886	mark	as,is
R8097	T26886	T26880	advcl	is,facilitate
R8098	T26887	T26888	det	the,case
R8099	T26888	T26886	attr	case,is
R8100	T26889	T26886	prep	in,is
R8101	T26890	T26889	pobj	retinoblastoma,in
R8102	T26891	T26892	punct	(,reviewed
R8103	T26892	T26886	parataxis	reviewed,is
R8104	T26893	T26892	prep	in,reviewed
R8105	T26894	T26893	punct	[,in
R8106	T26895	T26893	pobj	66,in
R8107	T26896	T26892	punct	],reviewed
R8108	T26897	T26892	punct	),reviewed
R8109	T26898	T26870	punct	.,is
R8110	T27218	T27219	advmod	How,Perturb
R8111	T27220	T27219	aux	Does,Perturb
R8112	T27221	T27219	nsubj	E2f3a,Perturb
R8113	T27222	T27223	compound	SAC,Differentiation
R8114	T27223	T27219	dobj	Differentiation,Perturb
R8115	T27224	T27219	punct	?,Perturb
R8116	T27226	T27227	nsubj	E2f3a,disrupt
R8117	T27228	T27227	aux	could,disrupt
R8118	T27229	T27230	compound	SAC,differentiation
R8119	T27230	T27227	dobj	differentiation,disrupt
R8120	T27231	T27227	prep	through,disrupt
R8121	T27232	T27233	poss	its,role
R8122	T27233	T27231	pobj	role,through
R8123	T27234	T27235	advmod	well,known
R8124	T27235	T27233	amod	known,role
R8125	T27236	T27233	prep	as,role
R8126	T27237	T27238	det	a,activator
R8127	T27238	T27236	pobj	activator,as
R8128	T27239	T27238	amod	transcriptional,activator
R8129	T27240	T27227	punct	", ",disrupt
R8130	T27241	T27227	cc	or,disrupt
R8131	T27242	T27227	punct	", ",disrupt
R8132	T27243	T27244	prep	in,affect
R8133	T27244	T27227	conj	affect,disrupt
R8134	T27245	T27243	pobj	view,in
R8135	T27246	T27245	prep	of,view
R8136	T27247	T27248	det	the,discovery
R8137	T27248	T27246	pobj	discovery,of
R8138	T27249	T27250	mark	that,is
R8139	T27250	T27248	acl	is,discovery
R8140	T27251	T27250	nsubj	it,is
R8141	T27252	T27253	advmod	partially,cytoplasmic
R8142	T27253	T27250	acomp	cytoplasmic,is
R8143	T27254	T27244	punct	", ",affect
R8144	T27255	T27244	nsubj	E2f3a,affect
R8145	T27256	T27244	aux	may,affect
R8146	T27257	T27244	dobj	processes,affect
R8147	T27258	T27257	amod	other,processes
R8148	T27259	T27258	prep	than,other
R8149	T27260	T27261	compound	gene,regulation
R8150	T27261	T27259	pobj	regulation,than
R8151	T27262	T27244	punct	.,affect
R8152	T27264	T27265	det	Both,scenarios
R8153	T27265	T27266	nsubj	scenarios,are
R8154	T27267	T27266	acomp	feasible,are
R8155	T27268	T27269	mark	since,regulate
R8156	T27269	T27266	advcl	regulate,are
R8157	T27270	T27269	nsubj	E2fs,regulate
R8158	T27271	T27272	compound	differentiation,genes
R8159	T27272	T27269	dobj	genes,regulate
R8160	T27273	T27274	punct	[,44
R8161	T27274	T27266	parataxis	44,are
R8162	T27275	T27276	punct	–,48
R8163	T27276	T27274	prep	48,44
R8164	T27277	T27274	punct	],44
R8165	T27278	T27266	punct	", ",are
R8166	T27279	T27266	cc	and,are
R8167	T27280	T27281	compound	cell,cycle
R8168	T27281	T27282	compound	cycle,regulators
R8169	T27282	T27283	nsubj	regulators,have
R8170	T27283	T27266	conj	have,are
R8171	T27284	T27282	punct	", ",regulators
R8172	T27285	T27286	amod	such,as
R8173	T27286	T27282	prep	as,regulators
R8174	T27287	T27286	pobj	Cdkn1b,as
R8175	T27288	T27283	punct	", ",have
R8176	T27289	T27290	amod	cytoplasmic,activities
R8177	T27290	T27283	dobj	activities,have
R8178	T27291	T27292	dep	that,influence
R8179	T27292	T27290	relcl	influence,activities
R8180	T27293	T27292	dobj	differentiation,influence
R8181	T27294	T27295	punct	[,69
R8182	T27295	T27283	parataxis	69,have
R8183	T27296	T27295	nummod	68,69
R8184	T27297	T27295	punct	",",69
R8185	T27298	T27295	punct	],69
R8186	T27299	T27283	punct	.,have
R8187	T27301	T27302	amod	Many,factors
R8188	T27302	T27304	nsubj	factors,shuttle
R8189	T27303	T27302	compound	transcription,factors
R8190	T27305	T27304	prep	between,shuttle
R8191	T27306	T27305	pobj	nucleus,between
R8192	T27307	T27306	cc	and,nucleus
R8193	T27308	T27306	conj	cytoplasm,nucleus
R8194	T27309	T27304	prep	during,shuttle
R8195	T27310	T27309	pobj	neurogenesis,during
R8196	T27311	T27312	punct	(,70
R8197	T27312	T27304	parataxis	70,shuttle
R8198	T27313	T27312	advmod	e.g.,70
R8199	T27314	T27312	punct	", ",70
R8200	T27315	T27312	punct	[,70
R8201	T27316	T27312	punct	],70
R8202	T27317	T27312	cc	and,70
R8203	T27318	T27312	conj	references,70
R8204	T27319	T27318	advmod	therein,references
R8205	T27320	T27312	punct	),70
R8206	T27321	T27304	punct	.,shuttle
R8207	T27323	T27324	nsubj	It,be
R8208	T27325	T27324	aux	may,be
R8209	T27326	T27324	acomp	difficult,be
R8210	T27327	T27328	aux	to,identify
R8211	T27328	T27324	xcomp	identify,be
R8212	T27329	T27330	npadvmod	E2f3a,specific
R8213	T27330	T27332	amod	specific,genes
R8214	T27331	T27330	punct	-,specific
R8215	T27332	T27328	dobj	genes,identify
R8216	T27333	T27332	compound	target,genes
R8217	T27334	T27332	cc	or,genes
R8218	T27335	T27336	amod	cytoplasmic,proteins
R8219	T27336	T27332	conj	proteins,genes
R8220	T27337	T27328	prep	in,identify
R8221	T27338	T27337	pobj	SACs,in
R8222	T27339	T27340	mark	since,are
R8223	T27340	T27324	advcl	are,be
R8224	T27341	T27342	det	these,neurons
R8225	T27342	T27340	nsubj	neurons,are
R8226	T27343	T27344	det	a,proportion
R8227	T27344	T27340	attr	proportion,are
R8228	T27345	T27344	amod	small,proportion
R8229	T27346	T27344	punct	(,proportion
R8230	T27347	T27348	punct	<,1
R8231	T27348	T27349	nummod	1,%
R8232	T27349	T27344	appos	%,proportion
R8233	T27350	T27344	punct	),proportion
R8234	T27351	T27344	prep	of,proportion
R8235	T27352	T27353	det	the,retina
R8236	T27353	T27351	pobj	retina,of
R8237	T27354	T27353	amod	total,retina
R8238	T27355	T27344	cc	and,proportion
R8239	T27356	T27357	advmod	only,5.2
R8240	T27357	T27359	nummod	5.2,%
R8241	T27358	T27357	punct	~,5.2
R8242	T27359	T27344	conj	%,proportion
R8243	T27360	T27359	prep	of,%
R8244	T27361	T27362	amod	amacrine,neurons
R8245	T27362	T27360	pobj	neurons,of
R8246	T27363	T27364	punct	[,38
R8247	T27364	T27340	parataxis	38,are
R8248	T27365	T27364	punct	],38
R8249	T27366	T27324	punct	.,be
R8250	T27794	T27795	aux	Do,Mediate
R8251	T27796	T27795	nsubj	E2fs,Mediate
R8252	T27797	T27798	det	All,Functions
R8253	T27798	T27795	dobj	Functions,Mediate
R8254	T27799	T27798	compound	Rb,Functions
R8255	T27800	T27795	punct	?,Mediate
R8256	T27802	T27803	nsubj	Others,suggested
R8257	T27804	T27803	aux	have,suggested
R8258	T27805	T27806	mark	that,promotes
R8259	T27806	T27803	ccomp	promotes,suggested
R8260	T27807	T27806	nsubj	Rb,promotes
R8261	T27808	T27806	dobj	differentiation,promotes
R8262	T27809	T27806	prep	in,promotes
R8263	T27810	T27811	amod	non-neuronal,cells
R8264	T27811	T27809	pobj	cells,in
R8265	T27812	T27806	prep	through,promotes
R8266	T27813	T27814	npadvmod	E2f,independent
R8267	T27814	T27816	amod	independent,means
R8268	T27815	T27814	punct	-,independent
R8269	T27816	T27812	pobj	means,through
R8270	T27817	T27818	punct	[,31
R8271	T27818	T27803	parataxis	31,suggested
R8272	T27819	T27820	punct	–,33
R8273	T27820	T27818	prep	33,31
R8274	T27821	T27818	punct	],31
R8275	T27822	T27803	punct	.,suggested
R8276	T27824	T27825	advmod	However,assess
R8277	T27826	T27825	punct	", ",assess
R8278	T27827	T27828	det	these,studies
R8279	T27828	T27825	nsubj	studies,assess
R8280	T27829	T27825	aux	did,assess
R8281	T27830	T27825	neg	not,assess
R8282	T27831	T27832	mark	whether,differentiate
R8283	T27832	T27825	ccomp	differentiate,assess
R8284	T27833	T27834	det	these,types
R8285	T27834	T27832	nsubj	types,differentiate
R8286	T27835	T27834	compound	cell,types
R8287	T27836	T27832	advmod	normally,differentiate
R8288	T27837	T27838	mark	if,deleted
R8289	T27838	T27832	advcl	deleted,differentiate
R8290	T27839	T27838	nsubjpass	Rb,deleted
R8291	T27840	T27838	auxpass	is,deleted
R8292	T27841	T27838	prep	along,deleted
R8293	T27842	T27841	prep	with,along
R8294	T27843	T27844	nummod	one,members
R8295	T27844	T27842	pobj	members,with
R8296	T27845	T27843	cc	or,one
R8297	T27846	T27843	conj	more,one
R8298	T27847	T27844	compound	E2f,members
R8299	T27848	T27844	compound	family,members
R8300	T27849	T27825	punct	.,assess
R8301	T27851	T27852	nummod	One,study
R8302	T27852	T27853	nsubj	study,reported
R8303	T27854	T27855	mark	that,induce
R8304	T27855	T27853	ccomp	induce,reported
R8305	T27856	T27857	compound	Rb,mutants
R8306	T27857	T27855	nsubj	mutants,induce
R8307	T27858	T27859	dep	that,bind
R8308	T27859	T27857	relcl	bind,mutants
R8309	T27860	T27859	aux	do,bind
R8310	T27861	T27859	neg	not,bind
R8311	T27862	T27859	dobj	E2f,bind
R8312	T27863	T27855	advmod	still,induce
R8313	T27864	T27855	dobj	differentiation,induce
R8314	T27865	T27866	punct	[,30
R8315	T27866	T27855	parataxis	30,induce
R8316	T27867	T27866	punct	],30
R8317	T27868	T27853	punct	.,reported
R8318	T27870	T27871	advmod	However,performed
R8319	T27872	T27871	punct	", ",performed
R8320	T27873	T27874	det	the,assays
R8321	T27874	T27871	nsubjpass	assays,performed
R8322	T27875	T27874	compound	binding,assays
R8323	T27876	T27871	auxpass	were,performed
R8324	T27877	T27871	prep	in,performed
R8325	T27878	T27877	pobj	solution,in
R8326	T27879	T27871	punct	", ",performed
R8327	T27880	T27871	cc	and,performed
R8328	T27881	T27882	nsubj	we,found
R8329	T27882	T27871	conj	found,performed
R8330	T27883	T27882	aux	have,found
R8331	T27884	T27885	mark	that,bind
R8332	T27885	T27882	ccomp	bind,found
R8333	T27886	T27885	nsubj	several,bind
R8334	T27887	T27886	prep	of,several
R8335	T27888	T27889	det	these,mutants
R8336	T27889	T27887	pobj	mutants,of
R8337	T27890	T27885	aux	do,bind
R8338	T27891	T27885	dobj	E2f,bind
R8339	T27892	T27885	punct	", ",bind
R8340	T27893	T27885	prep	albeit,bind
R8341	T27894	T27893	pcomp	weakly,albeit
R8342	T27895	T27885	punct	", ",bind
R8343	T27896	T27885	prep	on,bind
R8344	T27897	T27896	pobj	chromatin,on
R8345	T27898	T27899	punct	(,T.
R8346	T27899	T27885	meta	T.,bind
R8347	T27900	T27899	nmod	Yu,T.
R8348	T27901	T27899	cc	and,T.
R8349	T27902	T27899	conj	R.,T.
R8350	T27903	T27902	nmod	B.,R.
R8351	T27904	T27902	punct	", ",R.
R8352	T27905	T27906	amod	unpublished,data
R8353	T27906	T27902	conj	data,R.
R8354	T27907	T27906	punct	),data
R8355	T27908	T27882	punct	.,found
R8356	T27910	T27911	nsubj	It,is
R8357	T27912	T27911	acomp	possible,is
R8358	T27913	T27914	mark	that,be
R8359	T27914	T27911	advcl	be,is
R8360	T27915	T27916	npadvmod	Rb,mediated
R8361	T27916	T27918	amod	mediated,potentiation
R8362	T27917	T27916	punct	-,mediated
R8363	T27918	T27914	nsubj	potentiation,be
R8364	T27919	T27918	prep	of,potentiation
R8365	T27920	T27921	npadvmod	tissue,specific
R8366	T27921	T27923	amod	specific,factors
R8367	T27922	T27921	punct	-,specific
R8368	T27923	T27919	pobj	factors,of
R8369	T27924	T27923	compound	transcription,factors
R8370	T27925	T27914	aux	may,be
R8371	T27926	T27914	punct	", ",be
R8372	T27927	T27928	advmod	at,least
R8373	T27928	T27929	advmod	least,in
R8374	T27929	T27914	prep	in,be
R8375	T27930	T27931	det	some,cases
R8376	T27931	T27929	pobj	cases,in
R8377	T27932	T27914	punct	", ",be
R8378	T27933	T27934	det	a,activity
R8379	T27934	T27914	attr	activity,be
R8380	T27935	T27934	amod	redundant,activity
R8381	T27936	T27914	punct	", ",be
R8382	T27937	T27914	cc	and,be
R8383	T27938	T27939	mark	that,is
R8384	T27939	T27914	conj	is,be
R8385	T27940	T27941	det	the,function
R8386	T27941	T27939	nsubj	function,is
R8387	T27942	T27941	amod	only,function
R8388	T27943	T27941	amod	critical,function
R8389	T27944	T27941	compound	Rb,function
R8390	T27945	T27946	aux	to,inhibit
R8391	T27946	T27939	xcomp	inhibit,is
R8392	T27947	T27946	dobj	E2f,inhibit
R8393	T27948	T27911	punct	.,is
R8394	T27950	T27951	poss	Our,study
R8395	T27951	T27952	nsubj	study,is
R8396	T27953	T27954	det	the,first
R8397	T27954	T27952	attr	first,is
R8398	T27955	T27954	prep	to,first
R8399	T27956	T27957	poss	our,knowledge
R8400	T27957	T27955	pobj	knowledge,to
R8401	T27958	T27959	aux	to,assess
R8402	T27959	T27954	advcl	assess,first
R8403	T27960	T27959	advmod	comprehensively,assess
R8404	T27961	T27962	mark	whether,differentiate
R8405	T27962	T27959	ccomp	differentiate,assess
R8406	T27963	T27964	compound	Rb,KO
R8407	T27964	T27965	compound	KO,cells
R8408	T27965	T27962	nsubj	cells,differentiate
R8409	T27966	T27962	aux	can,differentiate
R8410	T27967	T27962	prep	in,differentiate
R8411	T27968	T27969	det	the,absence
R8412	T27969	T27967	pobj	absence,in
R8413	T27970	T27969	prep	of,absence
R8414	T27971	T27972	amod	different,E2fs
R8415	T27972	T27970	pobj	E2fs,of
R8416	T27973	T27952	punct	.,is
R8417	T27975	T27976	prep	In,be
R8418	T27977	T27975	pobj	light,In
R8419	T27978	T27977	prep	of,light
R8420	T27979	T27980	poss	our,findings
R8421	T27980	T27978	pobj	findings,of
R8422	T27981	T27976	punct	", ",be
R8423	T27982	T27976	nsubj	it,be
R8424	T27983	T27976	aux	will,be
R8425	T27984	T27976	acomp	important,be
R8426	T27985	T27986	aux	to,reassess
R8427	T27986	T27976	xcomp	reassess,be
R8428	T27987	T27988	compound	differentiation,defects
R8429	T27988	T27986	dobj	defects,reassess
R8430	T27989	T27988	prep	in,defects
R8431	T27990	T27991	amod	other,tissues
R8432	T27991	T27989	pobj	tissues,in
R8433	T27992	T27993	compound	Rb,KO
R8434	T27993	T27991	compound	KO,tissues
R8435	T27994	T27986	prep	in,reassess
R8436	T27995	T27996	det	the,absence
R8437	T27996	T27994	pobj	absence,in
R8438	T27997	T27996	prep	of,absence
R8439	T27998	T27999	amod	individual,members
R8440	T27999	T27997	pobj	members,of
R8441	T28000	T27998	cc	and,individual
R8442	T28001	T27998	conj	combined,individual
R8443	T28002	T27999	amod	activating,members
R8444	T28003	T27999	compound	E2f,members
R8445	T28004	T27999	compound	family,members
R8446	T28005	T27976	punct	.,be
R11654	T38541	T38542	nsubj	Rb,Regulates
R11655	T38543	T38544	amod	Distinct,Processes
R11656	T38544	T38542	dobj	Processes,Regulates
R11657	T38545	T38542	prep	through,Regulates
R11658	T38546	T38545	pobj	E2f1,through
R11659	T38547	T38546	cc	and,E2f1
R11660	T38548	T38546	conj	E2f3a,E2f1
R11661	T38550	T38551	amod	Red,text
R11662	T38551	T38552	nsubj	text,indicate
R11663	T38553	T38551	cc	and,text
R11664	T38554	T38551	conj	arrows,text
R11665	T38555	T38556	npadvmod	Rb,dependent
R11666	T38556	T38558	amod	dependent,events
R11667	T38557	T38556	punct	-,dependent
R11668	T38558	T38552	dobj	events,indicate
R11669	T38559	T38552	punct	.,indicate
R11670	T38561	T38562	amod	Black,text
R11671	T38562	T38563	nsubj	text,indicate
R11672	T38564	T38562	cc	and,text
R11673	T38565	T38562	conj	arrows,text
R11674	T38566	T38563	dobj	events,indicate
R11675	T38567	T38568	prep	for,is
R11676	T38568	T38566	relcl	is,events
R11677	T38569	T38567	pobj	which,for
R11678	T38570	T38568	expl	there,is
R11679	T38571	T38572	det	no,evidence
R11680	T38572	T38568	attr	evidence,is
R11681	T38573	T38572	amod	direct,evidence
R11682	T38574	T38572	prep	of,evidence
R11683	T38575	T38576	compound	Rb,involvement
R11684	T38576	T38574	pobj	involvement,of
R11685	T38577	T38563	punct	.,indicate
R11686	T38579	T38580	nsubj	Rb,appear
R11687	T38581	T38580	aux	does,appear
R11688	T38582	T38580	neg	not,appear
R11689	T38583	T38584	aux	to,temper
R11690	T38584	T38580	xcomp	temper,appear
R11691	T38585	T38586	compound	RPC,expansion
R11692	T38586	T38584	dobj	expansion,temper
R11693	T38587	T38580	cc	and,appear
R11694	T38588	T38589	auxpass	is,required
R11695	T38589	T38580	conj	required,appear
R11696	T38590	T38589	neg	not,required
R11697	T38591	T38589	prep	for,required
R11698	T38592	T38591	pobj	differentiation,for
R11699	T38593	T38592	prep	of,differentiation
R11700	T38594	T38593	pobj	RPCs,of
R11701	T38595	T38592	prep	into,differentiation
R11702	T38596	T38595	pobj	RTCs,into
R11703	T38597	T38589	punct	", ",required
R11704	T38598	T38589	cc	but,required
R11705	T38599	T38589	conj	is,required
R11706	T38600	T38599	acomp	essential,is
R11707	T38601	T38602	aux	to,couple
R11708	T38602	T38599	advcl	couple,is
R11709	T38603	T38604	compound	RTC,birth
R11710	T38604	T38602	dobj	birth,couple
R11711	T38605	T38602	prep	to,couple
R11712	T38606	T38607	amod	terminal,mitosis
R11713	T38607	T38605	pobj	mitosis,to
R11714	T38608	T38602	punct	", ",couple
R11715	T38609	T38610	advmod	thus,locking
R11716	T38610	T38602	advcl	locking,couple
R11717	T38611	T38610	dobj	them,locking
R11718	T38612	T38613	advmod	out,of
R11719	T38613	T38610	oprd	of,locking
R11720	T38614	T38613	pobj	cycle,of
R11721	T38615	T38580	punct	.,appear
R11722	T38617	T38618	nsubj	Rb,performs
R11723	T38619	T38620	det	this,function
R11724	T38620	T38618	dobj	function,performs
R11725	T38621	T38618	prep	by,performs
R11726	T38622	T38621	pcomp	inhibiting,by
R11727	T38623	T38622	dobj	E2f1,inhibiting
R11728	T38624	T38618	punct	.,performs
R11729	T38626	T38627	nsubjpass	Rb,required
R11730	T38628	T38627	auxpass	is,required
R11731	T38629	T38627	advmod	also,required
R11732	T38630	T38627	prep	for,required
R11733	T38631	T38632	compound	SAC,differentiation
R11734	T38632	T38630	pobj	differentiation,for
R11735	T38633	T38627	punct	", ",required
R11736	T38634	T38627	cc	and,required
R11737	T38635	T38636	prep	in,acts
R11738	T38636	T38627	conj	acts,required
R11739	T38637	T38638	det	this,case
R11740	T38638	T38635	pobj	case,in
R11741	T38639	T38636	punct	", ",acts
R11742	T38640	T38636	prep	by,acts
R11743	T38641	T38640	pcomp	inhibiting,by
R11744	T38642	T38641	dobj	E2f3a,inhibiting
R11745	T38643	T38627	punct	.,required
R11746	T38645	T38646	expl	There,is
R11747	T38647	T38648	det	no,evidence
R11748	T38648	T38646	attr	evidence,is
R11749	T38649	T38648	amod	direct,evidence
R11750	T38650	T38651	mark	that,required
R11751	T38651	T38648	acl	required,evidence
R11752	T38652	T38651	nsubjpass	Rb,required
R11753	T38653	T38651	auxpass	is,required
R11754	T38654	T38651	prep	for,required
R11755	T38655	T38656	amod	terminal,differentiation
R11756	T38656	T38654	pobj	differentiation,for
R11757	T38657	T38656	prep	of,differentiation
R11758	T38658	T38659	amod	other,types
R11759	T38659	T38657	pobj	types,of
R11760	T38660	T38659	compound	cell,types
R11761	T38661	T38646	punct	.,is
R11762	T38663	T38664	compound	Colour,codes
R11763	T38665	T38664	cc	and,codes
R11764	T38666	T38664	conj	abbreviations,codes
R11765	T38667	T38664	prep	as,codes
R11766	T38668	T38667	prep	in,as
R11767	T38669	T38670	compound	Figure,1A
R11768	T38670	T38668	pobj	1A,in
R11769	T38671	T38664	punct	.,codes
R7272	T24763	T24745	conj	proposed,contested
R7273	T24764	T24765	punct	[,63
R7274	T24765	T24763	parataxis	63,proposed
R7275	T24766	T24765	nummod	62,63
R7276	T24767	T24765	punct	",",63
R7277	T24768	T24765	punct	],63
R7278	T24769	T24763	punct	", ",proposed
R7279	T24770	T24771	cc	but,involving
R7280	T24771	T24763	dep	involving,proposed
R7281	T24772	T24771	neg	not,involving
R7282	T24773	T24774	compound	E2f,repression
R7283	T24774	T24771	dobj	repression,involving
R7284	T24775	T24763	punct	.,proposed
R7285	T24777	T24778	advmod	Strikingly,discovered
R7286	T24779	T24778	punct	", ",discovered
R7287	T24780	T24778	advmod	however,discovered
R7288	T24781	T24778	punct	", ",discovered
R7289	T24782	T24778	nsubj	we,discovered
R7290	T24783	T24784	mark	that,promotes
R7291	T24784	T24778	ccomp	promotes,discovered
R7292	T24785	T24784	nsubj	Rb,promotes
R7293	T24786	T24787	compound	SAC,differentiation
R7294	T24787	T24784	dobj	differentiation,promotes
R7295	T24788	T24784	prep	through,promotes
R7296	T24789	T24788	pobj	E2f3,through
R7297	T24790	T24791	punct	(,Figure
R7298	T24791	T24784	parataxis	Figure,promotes
R7299	T24792	T24791	nummod	8,Figure
R7300	T24793	T24791	punct	),Figure
R7301	T24794	T24778	punct	.,discovered
R7302	T24803	T24804	amod	a,"tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati"
R7303	T24806	T24807	advmod	o,f
R7304	T24807	T24805	oprd	f,on
R7305	T24809	T24810	compound	SAC,differentiation
R7306	T24820	T24823	ccomp	was,rescued
R7390	T24912	T24911	prep	of,subset
R7391	T24913	T24914	compound	CNS,neurons
R7392	T24914	T24912	pobj	neurons,of
R7393	T24915	T24916	punct	(,work
R7394	T24916	T24907	parataxis	work,expressed
R7395	T24917	T24916	det	this,work
R7396	T24918	T24916	punct	),work
R7397	T24919	T24907	cc	and,expressed
R7398	T24920	T24907	conj	drives,expressed
R7399	T24921	T24922	amod	specific,defects
R7401	T24923	T24924	compound	cell,cycle

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T22868	12-14	PR_EXT:000013773	denotes	Rb
T22869	15-23	GO:0065007	denotes	Controls
T22870	24-31	UBERON:0000966	denotes	Retinal
T22871	24-36	CL:0009004	denotes	Retinal Cell
T22872	32-36	CL_GO_EXT:cell	denotes	Cell
T22873	32-45	GO:0051301	denotes	Cell Division
T22874	32-36	_FRAGMENT	denotes	Cell
T22875	50-55	GO:0008219	denotes	Death
T22876	64-68	PR_EXT:000006852	denotes	E2f1
T22877	105-107	PR_EXT:000013773	denotes	Rb
T22878	133-141	CL:0000540	denotes	neuronal
T22879	142-146	CL_GO_EXT:cell	denotes	cell
T22880	142-152	GO:0007049	denotes	cell cycle
T22881	173-188	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22882	210-215	GO:0016265	denotes	death
T22883	273-282	UBERON:0001987	denotes	placental
T22884	354-356	PR_EXT:000013773	denotes	Rb
T22885	379-383	CL_GO_EXT:cell	denotes	cell
T22886	379-389	GO:0007049	denotes	cell cycle
T22887	406-413	CL:0000540	denotes	neurons
T22888	459-466	CL:0000540	denotes	neurons
T22889	488-494	UBERON:0000966	denotes	retina
T22890	531-533	PR_EXT:000013773	denotes	Rb
T22891	539-548	GO:0065007	denotes	regulates
T22892	549-564	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22893	633-638	GO:0016265	denotes	death
T22894	675-677	PR_EXT:000013773	denotes	Rb
T22895	682-690	GO:0065007	denotes	regulate
T22896	691-699	CL:0000540	denotes	neuronal
T22897	691-710	GO:0042551	denotes	neuronal maturation
T22898	742-750	SO_EXT:sequence_deletion_process	denotes	deleting
T22899	751-755	PR_EXT:000006852	denotes	E2f1
T22900	769-776	SO_EXT:sequence_rescue_process	denotes	rescued
T22901	798-803	GO:0016265	denotes	death
T22902	811-813	PR_EXT:000013773	denotes	Rb
T22903	817-823	UBERON:0000966	denotes	retina
T22904	844-846	PR_EXT:000013773	denotes	Rb
T22905	847-851	PR_EXT:000006852	denotes	E2f1
T22906	856-863	CL:0000540	denotes	neurons
T22907	864-878	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T22908	911-917	SO_EXT:sequence_rescue_process	denotes	rescue
T22909	921-924	CL:0000604	denotes	rod
T22910	930-934	CL:0000573	denotes	cone
T22911	976-987	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signal flow
T22912	993-1007	CL:0000210	denotes	photoreceptors
T22913	1011-1018	_FRAGMENT	denotes	bipolar
T22914	1032-1037	CL:0000103	denotes	cells
T22915	1023-1037	CL:0000561	denotes	amacrine cells
T22916	1032-1037	CL_GO_EXT:cell	denotes	cells
T22917	1052-1057	GO:0016265	denotes	death
T22918	1058-1063	SO_EXT:0000704	denotes	genes
T22919	1080-1082	PR_EXT:000013773	denotes	Rb
T22920	1086-1091	CL_GO_EXT:cell	denotes	cells
T22921	1097-1105	SO_EXT:sequence_deletion_process	denotes	deleting
T22922	1106-1110	PR_EXT:000006852	denotes	E2f1
T22923	1120-1124	PR_EXT:000006853	denotes	E2f2
T22924	1128-1132	PR_EXT:000006854	denotes	E2f3
T22925	1149-1158	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T22926	1167-1171	PR_EXT:000006852	denotes	E2f1
T22927	1181-1189	GO:0065007	denotes	regulate
T22928	1190-1205	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22929	1258-1265	UBERON:0000966	denotes	retinal
T22930	1258-1270	CL:0009004	denotes	retinal cell
T22931	1266-1270	CL_GO_EXT:cell	denotes	cell
T22932	1266-1281	GO:0048469	denotes	cell maturation
T22933	1352-1361	GO:0065007	denotes	regulated
T22934	1375-1380	GO:0016265	denotes	death
T22935	1420-1427	UBERON:0000966	denotes	retinal
T22936	1420-1433	CL:0009004	denotes	retinal cells
T22937	1428-1433	CL_GO_EXT:cell	denotes	cells
T22938	1445-1459	CL:0000210	denotes	photoreceptors
T22939	1466-1479	GO_EXT:transcription	denotes	transcription
T22940	1466-1487	GO_EXT:transcription_factor	denotes	transcription factors
T22941	1501-1516	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22942	1543-1545	PR_EXT:000013773	denotes	Rb
T22943	1571-1575	PR_EXT:000006852	denotes	E2f1
T22944	1576-1584	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T22945	1585-1592	SO_EXT:sequence_rescue_process	denotes	rescues
T22946	1593-1597	CL_GO_EXT:cell	denotes	cell
T22947	1627-1632	GO:0016265	denotes	death
T22948	1638-1653	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22949	1674-1676	PR_EXT:000013773	denotes	Rb
T22950	1680-1686	SO_EXT:sequence_cloned_entity	denotes	clones
T22951	1709-1719	NCBITaxon:11632	denotes	retrovirus
T22952	1720-1726	SO_EXT:0000440	denotes	vector
T22953	1816-1820	PR_EXT:000006852	denotes	E2f1
T22954	1825-1835	GO:0010467	denotes	expression
T22955	1847-1861	CL:0000210	denotes	photoreceptors
T22956	1890-1899	GO:0006915	denotes	apoptosis
T22957	1954-1958	PR_EXT:000006852	denotes	E2f1
T22958	2022-2026	PR_EXT:E2F	denotes	E2fs
T22959	2046-2055	GO:0006915	denotes	apoptosis
T22960	2059-2061	PR_EXT:000013773	denotes	Rb
T22961	2065-2070	CL_GO_EXT:cell	denotes	cells
T22962	2088-2097	GO:0065007	denotes	regulated
T22963	2098-2102	PR_EXT:000006852	denotes	E2f1
T22964	2119-2125	UBERON:0000966	denotes	retina
T22965	2170-2172	PR_EXT:000013773	denotes	Rb
T22966	2185-2195	GO:0010467	denotes	expression
T22967	2218-2222	CL_GO_EXT:cell	denotes	cell
T22968	2218-2231	GO:0051301	denotes	cell division
T22969	2245-2254	GO:0006915	denotes	apoptosis
T22970	2276-2280	PR_EXT:000006852	denotes	E2f1
T22971	2300-2304	PR_EXT:E2F	denotes	E2fs
T22972	2384-2387	PR_EXT:000013773	denotes	RB1
T22973	2388-2389	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22974	2390-2391	SO_EXT:sequence_nullness_or_absence	denotes	−
T22975	2392-2398	NCBITaxon:9606	denotes	humans
T22976	2425-2431	SO_EXT:sequence_rescue_process	denotes	rescue
T22977	2439-2441	PR_EXT:000013773	denotes	Rb
T22978	2445-2448	CL:0000604	denotes	rod
T22979	2449-2456	CL:0000103	denotes	bipolar
T22980	2504-2508	CL:0000573	denotes	cone
T22981	2509-2516	CL:0000103	denotes	bipolar
T22982	2534-2538	PR_EXT:000006852	denotes	E2f1
T22983	2539-2547	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T22984	2576-2584	GO_EXT:reaction_or_response	denotes	response
T22985	2592-2594	PR_EXT:000013773	denotes	Rb
T22986	2595-2599	PR_EXT:000006852	denotes	E2f1
T22987	2604-2610	UBERON:0000966	denotes	retina
T22988	2627-2631	PR_EXT:000006852	denotes	E2f1
T22989	2643-2649	UBERON:0000966	denotes	retina
T22990	2692-2694	PR_EXT:000013773	denotes	Rb
T22991	2702-2722	GO:0046549	denotes	development of cones
T22992	2702-2716	_FRAGMENT	denotes	development of
T22993	2732-2737	GO:0048468	denotes	cells
T22994	2748-2753	GO:0048468	denotes	cells
T22995	2717-2722	CL:0000573	denotes	cones
T22996	2724-2737	CL:0000103	denotes	bipolar cells
T22997	2732-2737	CL_GO_EXT:cell	denotes	cells
T22998	2748-2753	CL_GO_EXT:cell	denotes	cells
T22999	2781-2789	GO:0036367	denotes	photopic
T23000	2861-2863	PR_EXT:000013773	denotes	Rb
T23001	2864-2868	PR_EXT:000006852	denotes	E2f1
T23002	2873-2879	UBERON:0000966	denotes	retina
T24511	3107-3111	PR_EXT:000006852	denotes	E2f1
T24512	3188-3196	CHEBI_PR_EXT:protein	denotes	proteins
T24513	3264-3276	CL:0000099	denotes	interneurons
T24514	3360-3362	PR_EXT:000013773	denotes	Rb
T24515	3363-3372	GO:0065007	denotes	regulates
T24516	3373-3385	GO:0022008	denotes	neurogenesis
T24517	3402-3409	GO:0007067	denotes	mitosis
T24518	3411-3413	PR_EXT:000013773	denotes	Rb
T24519	3414-3419	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T24520	3467-3475	CL:0000540	denotes	neuronal
T24521	3476-3481	CL_GO_EXT:cell	denotes	cells
T24522	3491-3506	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T24523	3508-3518	CL:0000136	denotes	adipocytes
T24524	3524-3528	UBERON_EXT:bone_element_or_tissue	denotes	bone
T24525	3533-3538	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T24526	3555-3561	UBERON:0000479	denotes	tissue
T24527	3571-3584	GO_EXT:transcription	denotes	transcription
T24528	3571-3592	GO_EXT:transcription_factor	denotes	transcription factors
T24529	3606-3621	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24530	3645-3647	PR_EXT:000013773	denotes	Rb
T24531	3657-3663	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T24532	3664-3679	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24533	3696-3701	PR_EXT:000010875	denotes	Myod1
T24534	3788-3791	PR_EXT:E2F	denotes	E2f
T24535	3844-3846	PR_EXT:000013773	denotes	Rb
T24536	3860-3875	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24537	3884-3888	PR_EXT:000006854	denotes	E2f3
T24538	3911-3913	PR_EXT:000013773	denotes	Rb
T24539	3920-4595	GO:0007067	denotes	tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati
T24540	4605-4620	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24541	4629-4633	PR_EXT:000006854	denotes	E2f3
T24542	4665-4676	GO:0065007	denotes	controlling
T24543	4689-4694	GO:0016265	denotes	death
T24544	4696-4700	PR_EXT:000006854	denotes	E2f3
T24545	4701-4709	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T24546	4710-4717	SO_EXT:sequence_rescue_process	denotes	rescued
T24547	4718-4720	PR_EXT:000013773	denotes	Rb
T24548	4766-4779	GO:0008283	denotes	proliferation
T24549	4783-4788	GO:0016265	denotes	death
T24550	4798-4802	PR_EXT:000006852	denotes	E2f1
T24551	4803-4811	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T24552	4830-4843	GO:0008283	denotes	proliferation
T24553	4848-4853	GO:0016265	denotes	death
T24554	4866-4872	SO_EXT:sequence_rescue_process	denotes	rescue
T24555	4877-4892	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24556	4901-4910	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelling
T24557	4926-4930	PR_EXT:000006852	denotes	E2f1
T24558	4939-4943	PR_EXT:000006854	denotes	E2f3
T24559	4944-4952	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T24560	4962-4964	PR_EXT:000013773	denotes	Rb
T24561	4992-5000	SO_EXT:sequence_deletion_process	denotes	deleting
T24562	5001-5005	PR_EXT:000006852	denotes	E2f1
T24563	5015-5019	PR_EXT:000006854	denotes	E2f3
T24564	5032-5041	GO:0065007	denotes	regulated
T24565	5042-5052	GO:0010467	denotes	expression
T24566	5056-5060	CL_GO_EXT:cell	denotes	cell
T24567	5056-5066	GO:0007049	denotes	cell cycle
T24568	5071-5080	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T24569	5081-5086	SO_EXT:0000704	denotes	genes
T24570	5094-5096	PR_EXT:000013773	denotes	Rb
T24571	5100-5106	UBERON:0000966	denotes	retina
T24572	5108-5112	PR_EXT:000006854	denotes	E2f3
T24573	5116-5125	GO:0010467	denotes	expressed
T24574	5141-5144	UBERON:0001017	denotes	CNS
T24575	5141-5152	CL:0000117	denotes	CNS neurons
T24576	5185-5189	CL_GO_EXT:cell	denotes	cell
T24577	5185-5195	GO:0007049	denotes	cell-cycle
T24578	5219-5221	PR_EXT:000013773	denotes	Rb
T24579	5225-5234	UBERON:0001890	denotes	forebrain
T24580	5225-5242	CL:0012001	denotes	forebrain neurons
T24581	5255-5259	PR_EXT:000006854	denotes	E2f3
T24582	5325-5327	PR_EXT:000013773	denotes	Rb
T24583	5353-5361	CL:0000540	denotes	neuronal
T24584	5362-5377	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24585	5425-5427	PR_EXT:000013773	denotes	Rb
T24586	5454-5458	PR_EXT:000006854	denotes	E2f3
T24587	5459-5466	SO_EXT:0001060	denotes	isoform
T24588	5489-5504	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24589	5545-5547	PR_EXT:000013773	denotes	Rb
T24590	5592-5601	GO:0044838	denotes	quiescent
T24591	5602-5607	CL_GO_EXT:cell	denotes	cells
T24592	5698-5701	PR_EXT:E2F	denotes	E2f
T24593	5702-5709	CHEBI_PR_EXT:protein	denotes	protein
T24594	5710-5717	SO_EXT:0001060	denotes	isoform
T24595	5767-5769	PR_EXT:000013773	denotes	Rb
T24596	5770-5779	GO:0065007	denotes	regulates
T24597	5784-5799	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24598	5808-5813	PR_EXT:000028775	denotes	E2f3a
T24599	5875-5883	SO_EXT:sequence_deletion_process	denotes	deleting
T24600	5901-5907	SO_EXT:sequence_rescue_process	denotes	rescue
T24601	5912-5927	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24602	5981-5985	SO_EXT:sequence_nullness	denotes	null
T24603	5986-5990	NCBITaxon:10088	denotes	mice
T24604	6026-6028	PR_EXT:000013773	denotes	Rb
T24605	6040-6049	GO:0065007	denotes	regulates
T24606	6054-6069	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24607	6093-6097	PR_EXT:000006854	denotes	E2f3
T24608	6098-6105	SO_EXT:0001060	denotes	isoform
T25665	6457-6462	PR_EXT:000028775	denotes	E2f3a
T25666	6471-6478	GO:0005634	denotes	nuclear
T25644	6117-6122	PR_EXT:000028775	denotes	E2f3a
T25645	6133-6145	GO_PATO_EXT:biological_localization_process_or_quality	denotes	Localization
T25646	6150-6161	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T25647	6153-6161	CL_GO_EXT:cell	denotes	cellular
T25648	6174-6177	PR_EXT:E2F	denotes	E2f
T25649	6178-6186	SO_EXT:0001060	denotes	isoforms
T25650	6235-6240	PR_EXT:000028775	denotes	E2f3a
T25651	6261-6271	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T25652	6272-6283	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T25653	6289-6295	SO_EXT:sequence_coding_function	denotes	encode
T25654	6300-6303	SO_EXT:0001528	denotes	NLS
T25655	6305-6308	CHEBI_SO_EXT:DNA	denotes	DNA
T25656	6309-6316	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T25657	6351-6353	PR_EXT:000013773	denotes	Rb
T25658	6354-6361	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T25659	6362-6369	SO_EXT:0000417	denotes	domains
T25660	6403-6414	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T25661	6406-6414	CL_GO_EXT:cell	denotes	cellular
T25662	6442-6449	UBERON:0000966	denotes	retinal
T25663	6442-6455	CL:0009004	denotes	retinal cells
T25664	6450-6455	CL_GO_EXT:cell	denotes	cells
T25667	6483-6494	GO:0005737	denotes	cytoplasmic
T25668	6516-6523	GO:0005634	denotes	nuclear
T25669	6549-6556	CHEBI_EXT:residue	denotes	residue
T25670	6557-6566	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-termini
T25671	6570-6575	PR_EXT:000028775	denotes	E2f3a
T25672	6648-6652	PR_EXT:000006852	denotes	E2f1
T25673	6654-6658	PR_EXT:000006853	denotes	E2f2
T25674	6664-6669	PR_EXT:000028775	denotes	E2f3a
T25675	6670-6675	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T25676	6676-6681	PR_EXT:000005115	denotes	Ccna2
T25677	6698-6717	GO_EXT:negative_regulation	denotes	negative regulatory
T25678	6740-6744	PR_EXT:E2F	denotes	E2fs
T25679	6757-6764	GO:0051320	denotes	S-phase
T25680	6812-6818	SO_EXT:0000417	denotes	domain
T25681	6820-6825	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T25682	6833-6842	GO:0065007	denotes	regulated
T25683	6846-6851	PR_EXT:000005115	denotes	Ccna2
T25684	6865-6871	SO_EXT:0000417	denotes	domain
T25685	6937-6939	PR_EXT:000013773	denotes	Rb
T25686	6951-6955	PR_EXT:TFDP	denotes	Tfdp
T25687	6956-6964	CHEBI_PR_EXT:protein	denotes	proteins
T25688	6984-6987	PR_EXT:E2F	denotes	E2f
T25689	6988-7000	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T25690	7046-7048	PR_EXT:000013773	denotes	Rb
T25691	7053-7058	PR_EXT:000016269	denotes	Tfdp1
T25692	7059-7067	CHEBI_PR_EXT:protein	denotes	proteins
T25693	7072-7083	GO:0005737	denotes	cytoplasmic
T25694	7087-7094	UBERON:0000966	denotes	retinal
T25695	7087-7100	CL:0009004	denotes	retinal cells
T25696	7095-7100	CL_GO_EXT:cell	denotes	cells
T25697	7139-7141	PR_EXT:000013773	denotes	Rb
T25698	7146-7150	PR_EXT:000006854	denotes	E2f3
T25699	7153-7161	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localize
T25700	7169-7178	GO:0042995	denotes	processes
T25701	7184-7191	GO:0005634	denotes	nuclear
T25702	7192-7204	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T25703	7254-7258	PR_EXT:E2F	denotes	E2fs
T25704	7262-7277	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T25705	7278-7284	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T25706	7292-7296	PR_EXT:000006856	denotes	E2f5
T25707	7315-7322	GO:0005634	denotes	nucleus
T25708	7326-7335	GO:0005737	denotes	cytoplasm
T25709	7343-7347	PR_EXT:000006855	denotes	E2f4
T25710	7420-7425	PR_EXT:000028775	denotes	E2f3a
T25711	7443-7449	UBERON:0000966	denotes	retina
T25712	7508-7510	PR_EXT:000013773	denotes	Rb
T25713	7540-7545	PR_EXT:000028775	denotes	E2f3a
T25714	7599-7614	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T25715	7623-7628	PR_EXT:000028775	denotes	E2f3a
T26557	7652-7667	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T26558	7668-7670	PR_EXT:000013773	denotes	Rb
T26559	7723-7738	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T26560	7739-7744	CL_GO_EXT:cell	denotes	cells
T26561	7755-7759	CL_GO_EXT:cell	denotes	cell
T26562	7755-7765	GO:0007049	denotes	cell cycle
T26563	7773-7780	CL:0000540	denotes	neurons
T26564	7782-7785	_FRAGMENT	denotes	gut
T26565	7795-7804	UBERON:0003929	denotes	epithelia
T26566	7790-7804	UBERON:0019204	denotes	skin epithelia
T26567	7806-7812	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T26568	7818-7829	CL_UBERON_EXT:lens_fiber	denotes	lens fibres
T26569	7818-7829	CL:0011004	denotes	lens fibres
T26570	7861-7871	GO:0010467	denotes	expression
T26571	7899-7901	PR_EXT:000013773	denotes	Rb
T26572	7936-7941	CL_GO_EXT:cell	denotes	cells
T26573	8030-8045	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T26574	8046-8051	CL_GO_EXT:cell	denotes	cells
T26575	8107-8122	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T26576	8163-8169	UBERON:0000966	denotes	retina
T26577	8171-8186	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T26578	8198-8203	CL_GO_EXT:cell	denotes	cells
T26579	8231-8233	PR_EXT:000013773	denotes	Rb
T26580	8235-8242	GO_EXT:biological_movement_or_translocation_process	denotes	migrate
T26581	8269-8276	GO:0010467	denotes	express
T26582	8289-8296	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T26583	8321-8326	UBERON:0000955	denotes	brain
T26584	8328-8330	PR_EXT:000013773	denotes	Rb
T26585	8334-8341	CL:0000540	denotes	neurons
T26586	8342-8349	GO_EXT:biological_movement_or_translocation_process	denotes	migrate
T26587	8364-8380	UBERON:0003053	denotes	ventricular zone
T26588	8395-8400	PR_EXT:000016819	denotes	Tubb3
T26589	8402-8414	PR_EXT:000016819	denotes	βIII-tubulin
T26590	8445-8449	CHEBI:472552	denotes	BrdU
T26591	8463-8476	UBERON:0003929	denotes	gut epithelia
T26592	8478-8492	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T26593	8493-8504	CL:0000584	denotes	enterocytes
T26594	8505-8512	GO_EXT:biological_movement_or_translocation_process	denotes	migrate
T26595	8520-8525	GO_UBERON_EXT:villus	denotes	villi
T26596	8539-8549	GO:0010467	denotes	expression
T26597	8553-8562	CHEBI:28790	denotes	serotonin
T26598	8592-8596	CHEBI:472552	denotes	BrdU
T26599	8628-8643	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T26600	8679-8686	PR_EXT:000014968	denotes	Slc18a3
T26601	8691-8695	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T26602	8787-8792	CL_GO_EXT:cell	denotes	cells
T26603	8877-8892	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T26604	8905-8909	CL_GO_EXT:cell	denotes	cell
T26605	8963-8974	_FRAGMENT	denotes	division of
T26606	9002-9007	GO:0051301	denotes	cells
T26607	8986-9001	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T26608	9002-9007	CL_GO_EXT:cell	denotes	cells
T27186	9125-9130	PR_EXT:000028775	denotes	E2f3a
T27187	9143-9158	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T27188	9160-9165	PR_EXT:000028775	denotes	E2f3a
T27189	9184-9199	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27190	9233-9248	GO_EXT:transcription	denotes	transcriptional
T27191	9310-9321	GO:0005737	denotes	cytoplasmic
T27192	9323-9328	PR_EXT:000028775	denotes	E2f3a
T27193	9361-9365	SO_EXT:0000704	denotes	gene
T27194	9366-9376	GO:0065007	denotes	regulation
T27195	9412-9416	PR_EXT:E2F	denotes	E2fs
T27196	9417-9425	GO:0065007	denotes	regulate
T27197	9426-9441	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27198	9442-9447	SO_EXT:0000704	denotes	genes
T27199	9461-9465	CL_GO_EXT:cell	denotes	cell
T27200	9461-9471	GO:0007049	denotes	cell cycle
T27201	9472-9482	GO_EXT:regulator	denotes	regulators
T27202	9492-9498	PR_EXT:000003090	denotes	Cdkn1b
T27203	9505-9516	GO:0005737	denotes	cytoplasmic
T27204	9543-9558	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27205	9573-9586	GO_EXT:transcription	denotes	transcription
T27206	9573-9594	GO_EXT:transcription_factor	denotes	transcription factors
T27207	9595-9602	GO_EXT:biological_movement_or_translocation_process	denotes	shuttle
T27208	9611-9618	GO:0005634	denotes	nucleus
T27209	9623-9632	GO:0005737	denotes	cytoplasm
T27210	9640-9652	GO:0022008	denotes	neurogenesis
T27211	9722-9727	PR_EXT:000028775	denotes	E2f3a
T27212	9744-9749	SO_EXT:0000704	denotes	genes
T27213	9753-9764	GO:0005737	denotes	cytoplasmic
T27214	9765-9773	CHEBI_PR_EXT:protein	denotes	proteins
T27215	9794-9801	CL:0000540	denotes	neurons
T27216	9844-9850	UBERON:0000966	denotes	retina
T27217	9869-9885	CL:0000561	denotes	amacrine neurons
T27757	9896-9900	PR_EXT:E2F	denotes	E2fs
T27758	9913-9915	PR_EXT:000013773	denotes	Rb
T27759	9954-9956	PR_EXT:000013773	denotes	Rb
T27760	9966-9981	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27761	9989-9997	CL:0000540	denotes	neuronal
T27762	9998-10003	CL_GO_EXT:cell	denotes	cells
T27763	10012-10015	PR_EXT:E2F	denotes	E2f
T27764	10095-10099	CL_GO_EXT:cell	denotes	cell
T27765	10106-10119	GO_RO_EXT:developmental_differentiation_process	denotes	differentiate
T27766	10132-10134	PR_EXT:000013773	denotes	Rb
T27767	10138-10145	SO_EXT:sequence_deletion_process	denotes	deleted
T27768	10169-10172	PR_EXT:E2F	denotes	E2f
T27769	10213-10215	PR_EXT:000013773	denotes	Rb
T27770	10216-10223	SO_EXT:sequence_altered_entity	denotes	mutants
T27771	10236-10240	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T27772	10241-10244	PR_EXT:E2F	denotes	E2f
T27773	10258-10273	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27774	10293-10300	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T27775	10326-10334	CHEBI:75958	denotes	solution
T27776	10376-10383	SO_EXT:sequence_altered_entity	denotes	mutants
T27777	10387-10391	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T27778	10392-10395	PR_EXT:E2F	denotes	E2f
T27779	10415-10424	GO:0000785	denotes	chromatin
T27780	10482-10484	PR_EXT:000013773	denotes	Rb
T27781	10510-10516	UBERON:0000479	denotes	tissue
T27782	10526-10539	GO_EXT:transcription	denotes	transcription
T27783	10526-10547	GO_EXT:transcription_factor	denotes	transcription factors
T27784	10629-10631	PR_EXT:000013773	denotes	Rb
T27785	10655-10658	PR_EXT:E2F	denotes	E2f
T27786	10734-10736	PR_EXT:000013773	denotes	Rb
T27787	10740-10745	CL_GO_EXT:cell	denotes	cells
T27788	10750-10763	GO_RO_EXT:developmental_differentiation_process	denotes	differentiate
T27789	10792-10796	PR_EXT:E2F	denotes	E2fs
T27790	10857-10872	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27791	10890-10892	PR_EXT:000013773	denotes	Rb
T27792	10896-10903	UBERON:0000479	denotes	tissues
T27793	10957-10960	PR_EXT:E2F	denotes	E2f
T38522	3911-3913	PR_EXT:000013773	denotes	Rb
T38523	3914-3923	GO:0065007	denotes	Regulates
T38524	3951-3955	PR_EXT:000006852	denotes	E2f1
T38525	3960-3965	PR_EXT:000028775	denotes	E2f3a
T38526	3995-3997	PR_EXT:000013773	denotes	Rb
T38527	4095-4097	PR_EXT:000013773	denotes	Rb
T38528	4111-4113	PR_EXT:000013773	denotes	Rb
T38529	4140-4143	CL:0002672	denotes	RPC
T38530	4178-4193	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T38531	4197-4201	CL:0002672	denotes	RPCs
T38532	4262-4269	GO:0007067	denotes	mitosis
T38533	4303-4305	PR_EXT:000013773	denotes	Rb
T38534	4343-4347	PR_EXT:000006852	denotes	E2f1
T38535	4349-4351	PR_EXT:000013773	denotes	Rb
T38536	4377-4392	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T38537	4431-4436	PR_EXT:000028775	denotes	E2f3a
T38538	4471-4473	PR_EXT:000013773	denotes	Rb
T38539	4499-4514	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T38540	4524-4528	CL_GO_EXT:cell	denotes	cell
T24500	2882-2884	PR_EXT:000013773	denotes	Rb
T24501	2885-2893	GO:0065007	denotes	Controls
T24502	2898-2913	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T24503	2922-2927	PR_EXT:000028775	denotes	E2f3a
T24504	2942-2948	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T24505	3003-3010	UBERON:0000966	denotes	retinal
T24506	3011-3018	CL:0000540	denotes	neurons
T24507	3020-3024	PR_EXT:000006852	denotes	E2f1
T24508	3025-3033	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T24509	3062-3064	PR_EXT:000013773	denotes	Rb
T24510	3068-3079	CHEBI:15355	denotes	cholinergic
R6612	T22875	T22874	_lexicallyChainedTo	Death,Cell
R6613	T22914	T22913	_lexicallyChainedTo	cells,bipolar
R6614	T22993	T22992	_lexicallyChainedTo	cells,development of
R6615	T22994	T22992	_lexicallyChainedTo	cells,development of
R7835	T26565	T26564	_lexicallyChainedTo	epithelia,gut
R7836	T26606	T26605	_lexicallyChainedTo	cells,division of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T22813	1167-1171	PR:000006852	denotes	E2f1
T22814	1181-1189	GO:0065007	denotes	regulate
T22815	1258-1265	UBERON:0000966	denotes	retinal
T22816	1258-1270	CL:0009004	denotes	retinal cell
T22817	1266-1281	GO:0048469	denotes	cell maturation
T22818	1352-1361	GO:0065007	denotes	regulated
T22819	1375-1380	GO:0016265	denotes	death
T22820	1420-1427	UBERON:0000966	denotes	retinal
T22769	12-14	PR:000013773	denotes	Rb
T22770	15-23	GO:0065007	denotes	Controls
T22771	24-31	UBERON:0000966	denotes	Retinal
T22772	24-36	CL:0009004	denotes	Retinal Cell
T22773	32-45	GO:0051301	denotes	Cell Division
T22774	32-36	_FRAGMENT	denotes	Cell
T22775	50-55	GO:0008219	denotes	Death
T22776	64-68	PR:000006852	denotes	E2f1
T22777	105-107	PR:000013773	denotes	Rb
T22778	133-141	CL:0000540	denotes	neuronal
T22779	142-152	GO:0007049	denotes	cell cycle
T22780	210-215	GO:0016265	denotes	death
T22781	273-282	UBERON:0001987	denotes	placental
T22782	354-356	PR:000013773	denotes	Rb
T22783	379-389	GO:0007049	denotes	cell cycle
T22784	406-413	CL:0000540	denotes	neurons
T22785	459-466	CL:0000540	denotes	neurons
T22786	488-494	UBERON:0000966	denotes	retina
T22787	531-533	PR:000013773	denotes	Rb
T22788	539-548	GO:0065007	denotes	regulates
T22789	633-638	GO:0016265	denotes	death
T22790	675-677	PR:000013773	denotes	Rb
T22791	682-690	GO:0065007	denotes	regulate
T22792	691-699	CL:0000540	denotes	neuronal
T22793	691-710	GO:0042551	denotes	neuronal maturation
T22794	751-755	PR:000006852	denotes	E2f1
T22795	798-803	GO:0016265	denotes	death
T22796	811-813	PR:000013773	denotes	Rb
T22797	817-823	UBERON:0000966	denotes	retina
T22798	844-846	PR:000013773	denotes	Rb
T22799	847-851	PR:000006852	denotes	E2f1
T22800	856-863	CL:0000540	denotes	neurons
T22801	921-924	CL:0000604	denotes	rod
T22802	930-934	CL:0000573	denotes	cone
T22803	993-1007	CL:0000210	denotes	photoreceptors
T22804	1011-1018	_FRAGMENT	denotes	bipolar
T22805	1032-1037	CL:0000103	denotes	cells
T22806	1023-1037	CL:0000561	denotes	amacrine cells
T22807	1052-1057	GO:0016265	denotes	death
T22808	1058-1063	SO:0000704	denotes	genes
T22809	1080-1082	PR:000013773	denotes	Rb
T22810	1106-1110	PR:000006852	denotes	E2f1
T22811	1120-1124	PR:000006853	denotes	E2f2
T22812	1128-1132	PR:000006854	denotes	E2f3
T22821	1420-1433	CL:0009004	denotes	retinal cells
T22822	1445-1459	CL:0000210	denotes	photoreceptors
T22823	1543-1545	PR:000013773	denotes	Rb
T22824	1571-1575	PR:000006852	denotes	E2f1
T22825	1627-1632	GO:0016265	denotes	death
T22826	1674-1676	PR:000013773	denotes	Rb
T22827	1709-1719	NCBITaxon:11632	denotes	retrovirus
T22828	1720-1726	SO:0000440	denotes	vector
T22829	1816-1820	PR:000006852	denotes	E2f1
T22830	1825-1835	GO:0010467	denotes	expression
T22831	1847-1861	CL:0000210	denotes	photoreceptors
T22832	1890-1899	GO:0006915	denotes	apoptosis
T22833	1954-1958	PR:000006852	denotes	E2f1
T22834	2046-2055	GO:0006915	denotes	apoptosis
T22835	2059-2061	PR:000013773	denotes	Rb
T22836	2088-2097	GO:0065007	denotes	regulated
T22837	2098-2102	PR:000006852	denotes	E2f1
T22838	2119-2125	UBERON:0000966	denotes	retina
T22839	2170-2172	PR:000013773	denotes	Rb
T22840	2185-2195	GO:0010467	denotes	expression
T22841	2218-2231	GO:0051301	denotes	cell division
T22842	2245-2254	GO:0006915	denotes	apoptosis
T22843	2276-2280	PR:000006852	denotes	E2f1
T22844	2384-2387	PR:000013773	denotes	RB1
T22845	2392-2398	NCBITaxon:9606	denotes	humans
T22846	2439-2441	PR:000013773	denotes	Rb
T22847	2445-2448	CL:0000604	denotes	rod
T22848	2449-2456	CL:0000103	denotes	bipolar
T22849	2504-2508	CL:0000573	denotes	cone
T22850	2509-2516	CL:0000103	denotes	bipolar
T22851	2534-2538	PR:000006852	denotes	E2f1
T22852	2592-2594	PR:000013773	denotes	Rb
T22853	2595-2599	PR:000006852	denotes	E2f1
T22854	2604-2610	UBERON:0000966	denotes	retina
T22855	2627-2631	PR:000006852	denotes	E2f1
T22856	2643-2649	UBERON:0000966	denotes	retina
T22857	2692-2694	PR:000013773	denotes	Rb
T22858	2702-2722	GO:0046549	denotes	development of cones
T22859	2702-2716	_FRAGMENT	denotes	development of
T22860	2732-2737	GO:0048468	denotes	cells
T22861	2748-2753	GO:0048468	denotes	cells
T22862	2717-2722	CL:0000573	denotes	cones
T22863	2724-2737	CL:0000103	denotes	bipolar cells
T22864	2781-2789	GO:0036367	denotes	photopic
T22865	2861-2863	PR:000013773	denotes	Rb
T22866	2864-2868	PR:000006852	denotes	E2f1
T22867	2873-2879	UBERON:0000966	denotes	retina
T24468	5015-5019	PR:000006854	denotes	E2f3
T24469	5032-5041	GO:0065007	denotes	regulated
T24470	5042-5052	GO:0010467	denotes	expression
T24471	5056-5066	GO:0007049	denotes	cell cycle
T24472	5081-5086	SO:0000704	denotes	genes
T24473	5094-5096	PR:000013773	denotes	Rb
T24474	5100-5106	UBERON:0000966	denotes	retina
T24475	5108-5112	PR:000006854	denotes	E2f3
T24444	3467-3475	CL:0000540	denotes	neuronal
T24445	3491-3499	UBERON:0004288	denotes	skeletal
T24446	3508-3518	CL:0000136	denotes	adipocytes
T24447	3555-3561	UBERON:0000479	denotes	tissue
T24448	3645-3647	PR:000013773	denotes	Rb
T24449	3696-3701	PR:000010875	denotes	Myod1
T24450	3844-3846	PR:000013773	denotes	Rb
T24451	3884-3888	PR:000006854	denotes	E2f3
T24452	3911-3913	PR:000013773	denotes	Rb
T24453	3920-4595	GO:0007067	denotes	tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati
T24454	4629-4633	PR:000006854	denotes	E2f3
T24455	4665-4676	GO:0065007	denotes	controlling
T24456	4689-4694	GO:0016265	denotes	death
T24457	4696-4700	PR:000006854	denotes	E2f3
T24458	4718-4720	PR:000013773	denotes	Rb
T24459	4766-4779	GO:0008283	denotes	proliferation
T24460	4783-4788	GO:0016265	denotes	death
T24461	4798-4802	PR:000006852	denotes	E2f1
T24462	4830-4843	GO:0008283	denotes	proliferation
T24463	4848-4853	GO:0016265	denotes	death
T24464	4926-4930	PR:000006852	denotes	E2f1
T24465	4939-4943	PR:000006854	denotes	E2f3
T24466	4962-4964	PR:000013773	denotes	Rb
T24467	5001-5005	PR:000006852	denotes	E2f1
T24476	5116-5125	GO:0010467	denotes	expressed
T24477	5141-5144	UBERON:0001017	denotes	CNS
T24478	5141-5152	CL:0000117	denotes	CNS neurons
T24479	5185-5195	GO:0007049	denotes	cell-cycle
T24480	5219-5221	PR:000013773	denotes	Rb
T24481	5225-5234	UBERON:0001890	denotes	forebrain
T24482	5225-5242	CL:0012001	denotes	forebrain neurons
T24483	5255-5259	PR:000006854	denotes	E2f3
T24484	5325-5327	PR:000013773	denotes	Rb
T24485	5353-5361	CL:0000540	denotes	neuronal
T24486	5425-5427	PR:000013773	denotes	Rb
T24487	5454-5458	PR:000006854	denotes	E2f3
T24488	5459-5466	SO:0001060	denotes	isoform
T24489	5545-5547	PR:000013773	denotes	Rb
T24490	5592-5601	GO:0044838	denotes	quiescent
T24491	5710-5717	SO:0001060	denotes	isoform
T24492	5767-5769	PR:000013773	denotes	Rb
T24493	5770-5779	GO:0065007	denotes	regulates
T24494	5808-5813	PR:000028775	denotes	E2f3a
T24495	5986-5990	NCBITaxon:10088	denotes	mice
T24496	6026-6028	PR:000013773	denotes	Rb
T24497	6040-6049	GO:0065007	denotes	regulates
T24498	6093-6097	PR:000006854	denotes	E2f3
T24499	6098-6105	SO:0001060	denotes	isoform
T25603	6117-6122	PR:000028775	denotes	E2f3a
T25604	6178-6186	SO:0001060	denotes	isoforms
T25605	6235-6240	PR:000028775	denotes	E2f3a
T25606	6300-6303	SO:0001528	denotes	NLS
T25607	6351-6353	PR:000013773	denotes	Rb
T25608	6362-6369	SO:0000417	denotes	domains
T25609	6442-6449	UBERON:0000966	denotes	retinal
T25610	6442-6455	CL:0009004	denotes	retinal cells
T25611	6457-6462	PR:000028775	denotes	E2f3a
T25612	6471-6478	GO:0005634	denotes	nuclear
T25613	6483-6494	GO:0005737	denotes	cytoplasmic
T25614	6516-6523	GO:0005634	denotes	nuclear
T25615	6570-6575	PR:000028775	denotes	E2f3a
T25616	6648-6652	PR:000006852	denotes	E2f1
T25617	6654-6658	PR:000006853	denotes	E2f2
T25618	6664-6669	PR:000028775	denotes	E2f3a
T25619	6676-6681	PR:000005115	denotes	Ccna2
T25620	6757-6764	GO:0051320	denotes	S-phase
T25621	6812-6818	SO:0000417	denotes	domain
T25622	6833-6842	GO:0065007	denotes	regulated
T25623	6846-6851	PR:000005115	denotes	Ccna2
T25624	6865-6871	SO:0000417	denotes	domain
T25625	6937-6939	PR:000013773	denotes	Rb
T25626	7046-7048	PR:000013773	denotes	Rb
T25627	7053-7058	PR:000016269	denotes	Tfdp1
T25628	7072-7083	GO:0005737	denotes	cytoplasmic
T25629	7087-7094	UBERON:0000966	denotes	retinal
T25630	7087-7100	CL:0009004	denotes	retinal cells
T25631	7139-7141	PR:000013773	denotes	Rb
T25632	7146-7150	PR:000006854	denotes	E2f3
T25633	7169-7178	GO:0042995	denotes	processes
T25634	7184-7191	GO:0005634	denotes	nuclear
T25635	7292-7296	PR:000006856	denotes	E2f5
T25636	7315-7322	GO:0005634	denotes	nucleus
T25637	7326-7335	GO:0005737	denotes	cytoplasm
T25638	7343-7347	PR:000006855	denotes	E2f4
T25639	7420-7425	PR:000028775	denotes	E2f3a
T25640	7443-7449	UBERON:0000966	denotes	retina
T25641	7508-7510	PR:000013773	denotes	Rb
T25642	7540-7545	PR:000028775	denotes	E2f3a
T25643	7623-7628	PR:000028775	denotes	E2f3a
T26539	8163-8169	UBERON:0000966	denotes	retina
T26540	8231-8233	PR:000013773	denotes	Rb
T26541	8269-8276	GO:0010467	denotes	express
T26542	8321-8326	UBERON:0000955	denotes	brain
T26530	7668-7670	PR:000013773	denotes	Rb
T26531	7755-7765	GO:0007049	denotes	cell cycle
T26532	7773-7780	CL:0000540	denotes	neurons
T26533	7782-7785	_FRAGMENT	denotes	gut
T26534	7795-7804	UBERON:0003929	denotes	epithelia
T26535	7790-7804	UBERON:0019204	denotes	skin epithelia
T26536	7818-7829	CL:0011004	denotes	lens fibres
T26537	7861-7871	GO:0010467	denotes	expression
T26538	7899-7901	PR:000013773	denotes	Rb
T26543	8328-8330	PR:000013773	denotes	Rb
T26544	8334-8341	CL:0000540	denotes	neurons
T26545	8364-8380	UBERON:0003053	denotes	ventricular zone
T26546	8395-8400	PR:000016819	denotes	Tubb3
T26547	8402-8414	PR:000016819	denotes	βIII-tubulin
T26548	8445-8449	CHEBI:472552	denotes	BrdU
T26549	8463-8476	UBERON:0003929	denotes	gut epithelia
T26550	8493-8504	CL:0000584	denotes	enterocytes
T26551	8539-8549	GO:0010467	denotes	expression
T26552	8553-8562	CHEBI:28790	denotes	serotonin
T26553	8592-8596	CHEBI:472552	denotes	BrdU
T26554	8679-8686	PR:000014968	denotes	Slc18a3
T26555	8963-8974	_FRAGMENT	denotes	division of
T26556	9002-9007	GO:0051301	denotes	cells
T27179	9640-9652	GO:0022008	denotes	neurogenesis
T27180	9722-9727	PR:000028775	denotes	E2f3a
T27181	9744-9749	SO:0000704	denotes	genes
T27182	9753-9764	GO:0005737	denotes	cytoplasmic
T27183	9794-9801	CL:0000540	denotes	neurons
T27184	9844-9850	UBERON:0000966	denotes	retina
T27185	9869-9885	CL:0000561	denotes	amacrine neurons
T27744	9913-9915	PR:000013773	denotes	Rb
T27745	9954-9956	PR:000013773	denotes	Rb
T27747	10132-10134	PR:000013773	denotes	Rb
T27748	10213-10215	PR:000013773	denotes	Rb
T27749	10326-10334	CHEBI:75958	denotes	solution
T27750	10415-10424	GO:0000785	denotes	chromatin
T27751	10482-10484	PR:000013773	denotes	Rb
T27752	10510-10516	UBERON:0000479	denotes	tissue
T27753	10629-10631	PR:000013773	denotes	Rb
T27754	10734-10736	PR:000013773	denotes	Rb
T27755	10890-10892	PR:000013773	denotes	Rb
T27756	10896-10903	UBERON:0000479	denotes	tissues
T38511	3995-3997	PR:000013773	denotes	Rb
T38507	3911-3913	PR:000013773	denotes	Rb
T38508	3914-3923	GO:0065007	denotes	Regulates
T38509	3951-3955	PR:000006852	denotes	E2f1
T38510	3960-3965	PR:000028775	denotes	E2f3a
T38512	4095-4097	PR:000013773	denotes	Rb
T38513	4111-4113	PR:000013773	denotes	Rb
T38514	4140-4143	CL:0002672	denotes	RPC
T38515	4197-4201	CL:0002672	denotes	RPCs
T38516	4262-4269	GO:0007067	denotes	mitosis
T38517	4303-4305	PR:000013773	denotes	Rb
T38518	4343-4347	PR:000006852	denotes	E2f1
T38519	4349-4351	PR:000013773	denotes	Rb
T38520	4431-4436	PR:000028775	denotes	E2f3a
T38521	4471-4473	PR:000013773	denotes	Rb
T27166	9125-9130	PR:000028775	denotes	E2f3a
T27167	9160-9165	PR:000028775	denotes	E2f3a
T27168	9310-9321	GO:0005737	denotes	cytoplasmic
T27169	9323-9328	PR:000028775	denotes	E2f3a
T27170	9361-9365	SO:0000704	denotes	gene
T27171	9366-9376	GO:0065007	denotes	regulation
T27172	9417-9425	GO:0065007	denotes	regulate
T27173	9442-9447	SO:0000704	denotes	genes
T27174	9461-9471	GO:0007049	denotes	cell cycle
T27175	9492-9498	PR:000003090	denotes	Cdkn1b
T27176	9505-9516	GO:0005737	denotes	cytoplasmic
T27177	9611-9618	GO:0005634	denotes	nucleus
T27178	9623-9632	GO:0005737	denotes	cytoplasm
T27746	9989-9997	CL:0000540	denotes	neuronal
T24429	2882-2884	PR:000013773	denotes	Rb
T24430	2885-2893	GO:0065007	denotes	Controls
T24431	2922-2927	PR:000028775	denotes	E2f3a
T24432	3003-3010	UBERON:0000966	denotes	retinal
T24433	3011-3018	CL:0000540	denotes	neurons
T24434	3020-3024	PR:000006852	denotes	E2f1
T24435	3062-3064	PR:000013773	denotes	Rb
T24436	3068-3079	CHEBI:15355	denotes	cholinergic
T24437	3107-3111	PR:000006852	denotes	E2f1
T24438	3264-3276	CL:0000099	denotes	interneurons
T24439	3360-3362	PR:000013773	denotes	Rb
T24440	3363-3372	GO:0065007	denotes	regulates
T24441	3373-3385	GO:0022008	denotes	neurogenesis
T24442	3402-3409	GO:0007067	denotes	mitosis
T24443	3411-3413	PR:000013773	denotes	Rb
R6611	T22861	T22859	_lexicallyChainedTo	cells,development of
R7833	T26534	T26533	_lexicallyChainedTo	epithelia,gut
R7834	T26556	T26555	_lexicallyChainedTo	cells,division of
R6608	T22775	T22774	_lexicallyChainedTo	Death,Cell
R6609	T22805	T22804	_lexicallyChainedTo	cells,bipolar
R6610	T22860	T22859	_lexicallyChainedTo	cells,development of

2_test

Id	Subject	Object	Predicate	Lexical cue
17608565-1406933-84869008	190-192	1406933	denotes	26
17608565-1406932-84869008	190-192	1406932	denotes	26
17608565-7958874-84869008	190-192	7958874	denotes	26
17608565-12607001-84869009	292-294	12607001	denotes	12
17608565-12093735-84869009	292-294	12093735	denotes	12
17608565-12529408-84869009	292-294	12529408	denotes	12
17608565-15193257-84869010	496-497	15193257	denotes	2
17608565-15231717-84869011	498-499	15231717	denotes	3
17608565-12093735-84869012	500-502	12093735	denotes	13
17608565-12529408-84869013	503-505	12529408	denotes	14
17608565-7925271-84869014	506-508	7925271	denotes	56
17608565-9620848-84869014	506-508	9620848	denotes	56
17608565-9508781-84869014	506-508	9508781	denotes	56
17608565-11435948-84869014	506-508	11435948	denotes	56
17608565-14991054-84869015	1461-1463	14991054	denotes	29
17608565-11704831-84869016	1901-1903	11704831	denotes	60
17608565-9207076-84869017	2072-2074	9207076	denotes	10
17608565-15976820-84869018	2075-2077	15976820	denotes	15
17608565-11447760-84869019	3443-3445	11447760	denotes	43
17608565-8381715-84869020	3623-3625	8381715	denotes	31
17608565-11545733-84869020	3623-3625	11545733	denotes	31
17608565-8946919-84869020	3623-3625	8946919	denotes	31
17608565-10601020-84869021	3726-3728	10601020	denotes	61
17608565-11684023-84869022	3762-3764	11684023	denotes	62
17608565-11034201-84869023	3765-3767	11034201	denotes	63
17608565-15175242-84869024	5618-5620	15175242	denotes	19
17608565-10779352-84869025	6371-6373	10779352	denotes	16
17608565-8033208-84869026	6766-6768	8033208	denotes	64
17608565-7969176-84869027	6769-6771	7969176	denotes	65
17608565-11980909-84869028	6853-6855	11980909	denotes	18
17608565-9144196-84869029	7002-7004	9144196	denotes	20
17608565-9271426-84869029	7002-7004	9271426	denotes	20
17608565-9372959-84869029	7002-7004	9372959	denotes	20
17608565-10725332-84869030	7378-7380	10725332	denotes	23
17608565-15193257-84869031	8299-8300	15193257	denotes	2
17608565-12093735-84869032	8451-8453	12093735	denotes	13
17608565-17257418-84869033	8598-8600	17257418	denotes	67
17608565-11159908-84869034	9449-9451	11159908	denotes	44
17608565-12110166-84869034	9449-9451	12110166	denotes	44
17608565-12975318-84869034	9449-9451	12975318	denotes	44
17608565-15479636-84869034	9449-9451	15479636	denotes	44
17608565-16081278-84869034	9449-9451	16081278	denotes	44
17608565-16705040-84869035	9560-9562	16705040	denotes	68
17608565-15078817-84869036	9563-9565	15078817	denotes	69
17608565-17043310-84869037	9661-9663	17043310	denotes	70
17608565-9786999-84869038	9887-9889	9786999	denotes	38
17608565-8381715-84869039	10035-10037	8381715	denotes	31
17608565-11545733-84869039	10035-10037	11545733	denotes	31
17608565-8946919-84869039	10035-10037	8946919	denotes	31
17608565-9420334-84869040	10275-10277	9420334	denotes	30
T50692	190-192	1406933	denotes	26
T8827	190-192	1406932	denotes	26
T66937	190-192	7958874	denotes	26
T49577	292-294	12607001	denotes	12
T76010	292-294	12093735	denotes	12
T58357	292-294	12529408	denotes	12
T97555	496-497	15193257	denotes	2
T34975	498-499	15231717	denotes	3
T7298	500-502	12093735	denotes	13
T34038	503-505	12529408	denotes	14
T64450	506-508	7925271	denotes	56
T10775	506-508	9620848	denotes	56
T80701	506-508	9508781	denotes	56
T43950	506-508	11435948	denotes	56
T75521	1461-1463	14991054	denotes	29
T68435	1901-1903	11704831	denotes	60
T81560	2072-2074	9207076	denotes	10
T56207	2075-2077	15976820	denotes	15
T97762	3443-3445	11447760	denotes	43
T62413	3623-3625	8381715	denotes	31
T83034	3623-3625	11545733	denotes	31
T20471	3623-3625	8946919	denotes	31
T83077	3726-3728	10601020	denotes	61
T32657	3762-3764	11684023	denotes	62
T9102	3765-3767	11034201	denotes	63
T68445	5618-5620	15175242	denotes	19
T70038	6371-6373	10779352	denotes	16
T93814	6766-6768	8033208	denotes	64
T18238	6769-6771	7969176	denotes	65
T97278	6853-6855	11980909	denotes	18
T66114	7002-7004	9144196	denotes	20
T4989	7002-7004	9271426	denotes	20
T40985	7002-7004	9372959	denotes	20
T9363	7378-7380	10725332	denotes	23
T26827	8299-8300	15193257	denotes	2
T3293	8451-8453	12093735	denotes	13
T21186	8598-8600	17257418	denotes	67
T68946	9449-9451	11159908	denotes	44
T3612	9449-9451	12110166	denotes	44
T53323	9449-9451	12975318	denotes	44
T58579	9449-9451	15479636	denotes	44
T65898	9449-9451	16081278	denotes	44
T53939	9560-9562	16705040	denotes	68
T93030	9563-9565	15078817	denotes	69
T27591	9661-9663	17043310	denotes	70
T75934	9887-9889	9786999	denotes	38
T14653	10035-10037	8381715	denotes	31
T48566	10035-10037	11545733	denotes	31
T64689	10035-10037	8946919	denotes	31
T38020	10275-10277	9420334	denotes	30

PMC:1914394 / 43095-54071 JSONTXT

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craft-sa-dev

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2_test

PMC:1914394 / 43095-54071 JSON TXT