Id |
Subject |
Object |
Predicate |
Lexical cue |
T21518 |
118-119 |
-RRB- |
denotes |
) |
T21519 |
119-120 |
. |
denotes |
. |
T21520 |
120-223 |
sentence |
denotes |
The genotyping strategy outlined in Figure 7A was used to distinguish the E2f3a, WT, and null alleles. |
T21495 |
0-2 |
TO |
denotes |
To |
T21496 |
3-7 |
VB |
denotes |
test |
T21497 |
84-93 |
VBD |
denotes |
exploited |
T21498 |
8-13 |
WDT |
denotes |
which |
T21499 |
19-26 |
NN |
denotes |
isoform |
T21500 |
14-18 |
NN |
denotes |
E2f3 |
T21501 |
27-29 |
VBZ |
denotes |
is |
T21502 |
30-41 |
JJ |
denotes |
responsible |
T21503 |
42-45 |
IN |
denotes |
for |
T21504 |
46-54 |
JJ |
denotes |
aberrant |
T21505 |
65-80 |
NN |
denotes |
differentiation |
T21506 |
55-57 |
NN |
denotes |
Rb |
T21507 |
58-60 |
NN |
denotes |
KO |
T21508 |
61-64 |
NN |
denotes |
SAC |
T21509 |
81-83 |
PRP |
denotes |
we |
T21510 |
94-99 |
NN |
denotes |
E2f3a |
T21511 |
103-107 |
NNS |
denotes |
mice |
T21512 |
99-100 |
SYM |
denotes |
− |
T21513 |
100-101 |
HYPH |
denotes |
/ |
T21514 |
101-102 |
SYM |
denotes |
− |
T21515 |
108-109 |
-LRB- |
denotes |
( |
T21516 |
116-118 |
NN |
denotes |
7A |
T21517 |
109-115 |
NN |
denotes |
Figure |
T21521 |
121-124 |
DT |
denotes |
The |
T21522 |
136-144 |
NN |
denotes |
strategy |
T21523 |
125-135 |
NN |
denotes |
genotyping |
T21524 |
171-175 |
VBN |
denotes |
used |
T21525 |
145-153 |
VBN |
denotes |
outlined |
T21526 |
154-156 |
IN |
denotes |
in |
T21527 |
157-163 |
NN |
denotes |
Figure |
T21528 |
164-166 |
NN |
denotes |
7A |
T21529 |
167-170 |
VBD |
denotes |
was |
T21530 |
176-178 |
TO |
denotes |
to |
T21531 |
179-190 |
VB |
denotes |
distinguish |
T21532 |
191-194 |
DT |
denotes |
the |
T21533 |
215-222 |
NNS |
denotes |
alleles |
T21534 |
195-200 |
NN |
denotes |
E2f3a |
T21535 |
200-202 |
, |
denotes |
, |
T21536 |
202-204 |
NN |
denotes |
WT |
T21537 |
204-206 |
, |
denotes |
, |
T21538 |
206-209 |
CC |
denotes |
and |
T21539 |
210-214 |
JJ |
denotes |
null |
T21540 |
222-223 |
. |
denotes |
. |
T21541 |
223-420 |
sentence |
denotes |
Reverse transcriptase PCR (RT-PCR) confirmed the presence of both E2f3a and E2f3b RNA species in the developing WT retina, and the specific absence of E2f3a RNA in the E2f3a−/− retina (Figure 7B). |
T21542 |
224-231 |
JJ |
denotes |
Reverse |
T21543 |
246-249 |
NN |
denotes |
PCR |
T21544 |
232-245 |
NN |
denotes |
transcriptase |
T21545 |
259-268 |
VBD |
denotes |
confirmed |
T21546 |
250-251 |
-LRB- |
denotes |
( |
T21547 |
251-253 |
NN |
denotes |
RT |
T21548 |
254-257 |
NN |
denotes |
PCR |
T21549 |
253-254 |
HYPH |
denotes |
- |
T21550 |
257-258 |
-RRB- |
denotes |
) |
T21551 |
269-272 |
DT |
denotes |
the |
T21552 |
273-281 |
NN |
denotes |
presence |
T21553 |
282-284 |
IN |
denotes |
of |
T21554 |
285-289 |
CC |
denotes |
both |
T21555 |
290-295 |
NN |
denotes |
E2f3a |
T21556 |
310-317 |
NNS |
denotes |
species |
T21557 |
296-299 |
CC |
denotes |
and |
T21558 |
300-305 |
NN |
denotes |
E2f3b |
T21559 |
306-309 |
NN |
denotes |
RNA |
T21560 |
318-320 |
IN |
denotes |
in |
T21561 |
321-324 |
DT |
denotes |
the |
T21562 |
339-345 |
NN |
denotes |
retina |
T21563 |
325-335 |
VBG |
denotes |
developing |
T21564 |
336-338 |
NN |
denotes |
WT |
T21565 |
345-347 |
, |
denotes |
, |
T21566 |
347-350 |
CC |
denotes |
and |
T21567 |
351-354 |
DT |
denotes |
the |
T21568 |
364-371 |
NN |
denotes |
absence |
T21569 |
355-363 |
JJ |
denotes |
specific |
T21570 |
372-374 |
IN |
denotes |
of |
T21571 |
375-380 |
NN |
denotes |
E2f3a |
T21572 |
381-384 |
NN |
denotes |
RNA |
T21573 |
385-387 |
IN |
denotes |
in |
T21574 |
388-391 |
DT |
denotes |
the |
T21575 |
401-407 |
NN |
denotes |
retina |
T21576 |
392-397 |
NN |
denotes |
E2f3a |
T21577 |
397-398 |
SYM |
denotes |
− |
T21578 |
398-399 |
HYPH |
denotes |
/ |
T21579 |
399-400 |
SYM |
denotes |
− |
T21580 |
408-409 |
-LRB- |
denotes |
( |
T21581 |
416-418 |
NN |
denotes |
7B |
T21582 |
409-415 |
NN |
denotes |
Figure |
T21583 |
418-419 |
-RRB- |
denotes |
) |
T21584 |
419-420 |
. |
denotes |
. |
T21585 |
420-492 |
sentence |
denotes |
E2f3a protein was absent in E2f3a−/− retinal lysate (Figures 6 and S8). |
T21586 |
421-426 |
NN |
denotes |
E2f3a |
T21587 |
427-434 |
NN |
denotes |
protein |
T21588 |
435-438 |
VBD |
denotes |
was |
T21589 |
439-445 |
JJ |
denotes |
absent |
T21590 |
446-448 |
IN |
denotes |
in |
T21591 |
449-454 |
NN |
denotes |
E2f3a |
T21592 |
466-472 |
NN |
denotes |
lysate |
T21593 |
454-455 |
SYM |
denotes |
− |
T21594 |
455-456 |
HYPH |
denotes |
/ |
T21595 |
456-457 |
SYM |
denotes |
− |
T21596 |
458-465 |
JJ |
denotes |
retinal |
T21597 |
473-474 |
-LRB- |
denotes |
( |
T21598 |
488-490 |
NN |
denotes |
S8 |
T21599 |
474-481 |
NNS |
denotes |
Figures |
T21600 |
482-483 |
CD |
denotes |
6 |
T21601 |
484-487 |
CC |
denotes |
and |
T21602 |
490-491 |
-RRB- |
denotes |
) |
T21603 |
491-492 |
. |
denotes |
. |
T21604 |
492-713 |
sentence |
denotes |
Importantly, the levels of E2f3b message were similar in the Rb KO and Rb/E2f3a DKO retina, ruling out the possibility that any effects of E2f3a deletion we might observe were due to down-regulation of E2f3b (Figure 7C). |
T21605 |
493-504 |
RB |
denotes |
Importantly |
T21606 |
534-538 |
VBD |
denotes |
were |
T21607 |
504-506 |
, |
denotes |
, |
T21608 |
506-509 |
DT |
denotes |
the |
T21609 |
510-516 |
NNS |
denotes |
levels |
T21610 |
517-519 |
IN |
denotes |
of |
T21611 |
520-525 |
NN |
denotes |
E2f3b |
T21612 |
526-533 |
NN |
denotes |
message |
T21613 |
539-546 |
JJ |
denotes |
similar |
T21614 |
547-549 |
IN |
denotes |
in |
T21615 |
550-553 |
DT |
denotes |
the |
T21616 |
577-583 |
NN |
denotes |
retina |
T21617 |
554-556 |
NN |
denotes |
Rb |
T21618 |
557-559 |
NN |
denotes |
KO |
T21619 |
560-563 |
CC |
denotes |
and |
T21620 |
564-566 |
NN |
denotes |
Rb |
T21621 |
567-572 |
NN |
denotes |
E2f3a |
T21622 |
566-567 |
HYPH |
denotes |
/ |
T21623 |
573-576 |
NN |
denotes |
DKO |
T21624 |
583-585 |
, |
denotes |
, |
T21625 |
585-591 |
VBG |
denotes |
ruling |
T21626 |
592-595 |
RP |
denotes |
out |
T21627 |
596-599 |
DT |
denotes |
the |
T21628 |
600-611 |
NN |
denotes |
possibility |
T21629 |
612-616 |
IN |
denotes |
that |
T21630 |
664-668 |
VBD |
denotes |
were |
T21631 |
617-620 |
DT |
denotes |
any |
T21632 |
621-628 |
NNS |
denotes |
effects |
T21633 |
629-631 |
IN |
denotes |
of |
T21634 |
632-637 |
NN |
denotes |
E2f3a |
T21635 |
638-646 |
NN |
denotes |
deletion |
T21636 |
647-649 |
PRP |
denotes |
we |
T21637 |
656-663 |
VB |
denotes |
observe |
T21638 |
650-655 |
MD |
denotes |
might |
T21639 |
669-672 |
IN |
denotes |
due |
T21640 |
673-675 |
IN |
denotes |
to |
T21641 |
676-680 |
JJ |
denotes |
down |
T21642 |
681-691 |
NN |
denotes |
regulation |
T21643 |
680-681 |
HYPH |
denotes |
- |
T21644 |
692-694 |
IN |
denotes |
of |
T21645 |
695-700 |
NN |
denotes |
E2f3b |
T21646 |
701-702 |
-LRB- |
denotes |
( |
T21647 |
709-711 |
NN |
denotes |
7C |
T21648 |
702-708 |
NN |
denotes |
Figure |
T21649 |
711-712 |
-RRB- |
denotes |
) |
T21650 |
712-713 |
. |
denotes |
. |
T21651 |
713-868 |
sentence |
denotes |
Also, the levels of other E2fs were the same in the Rb KO, Rb/E2f3 DKO, and Rb/E2f3a DKO retina, ruling out any cross-regulatory effects (Figure 7C) [55]. |
T21652 |
714-718 |
RB |
denotes |
Also |
T21653 |
745-749 |
VBD |
denotes |
were |
T21654 |
718-720 |
, |
denotes |
, |
T21655 |
720-723 |
DT |
denotes |
the |
T21656 |
724-730 |
NNS |
denotes |
levels |
T21657 |
731-733 |
IN |
denotes |
of |
T21658 |
734-739 |
JJ |
denotes |
other |
T21659 |
740-744 |
NNS |
denotes |
E2fs |
T21660 |
750-753 |
DT |
denotes |
the |
T21661 |
754-758 |
JJ |
denotes |
same |
T21662 |
759-761 |
IN |
denotes |
in |
T21663 |
762-765 |
DT |
denotes |
the |
T21664 |
803-809 |
NN |
denotes |
retina |
T21665 |
766-768 |
NN |
denotes |
Rb |
T21666 |
769-771 |
NN |
denotes |
KO |
T21667 |
771-773 |
, |
denotes |
, |
T21668 |
773-775 |
NN |
denotes |
Rb |
T21669 |
776-780 |
NN |
denotes |
E2f3 |
T21670 |
775-776 |
HYPH |
denotes |
/ |
T21671 |
781-784 |
NN |
denotes |
DKO |
T21672 |
784-786 |
, |
denotes |
, |
T21673 |
786-789 |
CC |
denotes |
and |
T21674 |
790-792 |
NN |
denotes |
Rb |
T21675 |
793-798 |
NN |
denotes |
E2f3a |
T21676 |
792-793 |
HYPH |
denotes |
/ |
T21677 |
799-802 |
NN |
denotes |
DKO |
T21678 |
809-811 |
, |
denotes |
, |
T21679 |
811-817 |
VBG |
denotes |
ruling |
T21680 |
818-821 |
RP |
denotes |
out |
T21681 |
822-825 |
DT |
denotes |
any |
T21682 |
843-850 |
NNS |
denotes |
effects |
T21683 |
826-831 |
RB |
denotes |
cross |
T21684 |
832-842 |
JJ |
denotes |
regulatory |
T21685 |
831-832 |
HYPH |
denotes |
- |
T21686 |
851-852 |
-LRB- |
denotes |
( |
T21687 |
859-861 |
NN |
denotes |
7C |
T21688 |
852-858 |
NN |
denotes |
Figure |
T21689 |
861-862 |
-RRB- |
denotes |
) |
T21690 |
863-864 |
-LRB- |
denotes |
[ |
T21691 |
864-866 |
CD |
denotes |
55 |
T21692 |
866-867 |
-RRB- |
denotes |
] |
T21693 |
867-868 |
. |
denotes |
. |
T21694 |
868-1153 |
sentence |
denotes |
E2f3a can trigger cell cycle induction, but because SAC defects are not linked to cell cycle perturbation (Figures 3A and 4), and in view of the predominant association between E2f3b and Rb in quiescent cells [16,19], we suspected that E2f3b may perturb differentiation in Rb KO SACs. |
T21695 |
869-874 |
NN |
denotes |
E2f3a |
T21696 |
879-886 |
VB |
denotes |
trigger |
T21697 |
875-878 |
MD |
denotes |
can |
T21698 |
887-891 |
NN |
denotes |
cell |
T21699 |
892-897 |
NN |
denotes |
cycle |
T21700 |
898-907 |
NN |
denotes |
induction |
T21701 |
907-909 |
, |
denotes |
, |
T21702 |
909-912 |
CC |
denotes |
but |
T21703 |
913-920 |
IN |
denotes |
because |
T21704 |
941-947 |
VBN |
denotes |
linked |
T21705 |
921-924 |
NN |
denotes |
SAC |
T21706 |
925-932 |
NNS |
denotes |
defects |
T21707 |
933-936 |
VBP |
denotes |
are |
T21708 |
937-940 |
RB |
denotes |
not |
T21709 |
1090-1099 |
VBD |
denotes |
suspected |
T21710 |
948-950 |
IN |
denotes |
to |
T21711 |
951-955 |
NN |
denotes |
cell |
T21712 |
956-961 |
NN |
denotes |
cycle |
T21713 |
962-974 |
NN |
denotes |
perturbation |
T21714 |
975-976 |
-LRB- |
denotes |
( |
T21715 |
984-986 |
NN |
denotes |
3A |
T21716 |
976-983 |
NNS |
denotes |
Figures |
T21717 |
987-990 |
CC |
denotes |
and |
T21718 |
991-992 |
CD |
denotes |
4 |
T21719 |
992-993 |
-RRB- |
denotes |
) |
T21720 |
993-995 |
, |
denotes |
, |
T21721 |
995-998 |
CC |
denotes |
and |
T21722 |
999-1001 |
IN |
denotes |
in |
T21723 |
1002-1006 |
NN |
denotes |
view |
T21724 |
1007-1009 |
IN |
denotes |
of |
T21725 |
1010-1013 |
DT |
denotes |
the |
T21726 |
1026-1037 |
NN |
denotes |
association |
T21727 |
1014-1025 |
JJ |
denotes |
predominant |
T21728 |
1038-1045 |
IN |
denotes |
between |
T21729 |
1046-1051 |
NN |
denotes |
E2f3b |
T21730 |
1052-1055 |
CC |
denotes |
and |
T21731 |
1056-1058 |
NN |
denotes |
Rb |
T21732 |
1059-1061 |
IN |
denotes |
in |
T21733 |
1062-1071 |
JJ |
denotes |
quiescent |
T21734 |
1072-1077 |
NNS |
denotes |
cells |
T21735 |
1078-1079 |
-LRB- |
denotes |
[ |
T21736 |
1082-1084 |
CD |
denotes |
19 |
T21737 |
1079-1081 |
CD |
denotes |
16 |
T21738 |
1081-1082 |
, |
denotes |
, |
T21739 |
1084-1085 |
-RRB- |
denotes |
] |
T21740 |
1085-1087 |
, |
denotes |
, |
T21741 |
1087-1089 |
PRP |
denotes |
we |
T21742 |
1100-1104 |
IN |
denotes |
that |
T21743 |
1115-1122 |
VB |
denotes |
perturb |
T21744 |
1105-1110 |
NN |
denotes |
E2f3b |
T21745 |
1111-1114 |
MD |
denotes |
may |
T21746 |
1123-1138 |
NN |
denotes |
differentiation |
T21747 |
1139-1141 |
IN |
denotes |
in |
T21748 |
1142-1144 |
NN |
denotes |
Rb |
T21749 |
1145-1147 |
NN |
denotes |
KO |
T21750 |
1148-1152 |
NNS |
denotes |
SACs |
T21751 |
1152-1153 |
. |
denotes |
. |
T21752 |
1153-1236 |
sentence |
denotes |
Unexpectedly, however, E2f3a deletion suppressed the Rb KO SAC defect (Figure 7D). |
T21753 |
1154-1166 |
RB |
denotes |
Unexpectedly |
T21754 |
1192-1202 |
VBD |
denotes |
suppressed |
T21755 |
1166-1168 |
, |
denotes |
, |
T21756 |
1168-1175 |
RB |
denotes |
however |
T21757 |
1175-1177 |
, |
denotes |
, |
T21758 |
1177-1182 |
NN |
denotes |
E2f3a |
T21759 |
1183-1191 |
NN |
denotes |
deletion |
T21760 |
1203-1206 |
DT |
denotes |
the |
T21761 |
1217-1223 |
NN |
denotes |
defect |
T21762 |
1207-1209 |
NN |
denotes |
Rb |
T21763 |
1210-1212 |
NN |
denotes |
KO |
T21764 |
1213-1216 |
NN |
denotes |
SAC |
T21765 |
1224-1225 |
-LRB- |
denotes |
( |
T21766 |
1232-1234 |
NN |
denotes |
7D |
T21767 |
1225-1231 |
NN |
denotes |
Figure |
T21768 |
1234-1235 |
-RRB- |
denotes |
) |
T21769 |
1235-1236 |
. |
denotes |
. |
T21770 |
1236-1366 |
sentence |
denotes |
Thus, separate from its role in cell cycle control, Rb regulation of E2f3a is critical to ensure proper neuronal differentiation. |
T21771 |
1237-1241 |
RB |
denotes |
Thus |
T21772 |
1312-1314 |
VBZ |
denotes |
is |
T21773 |
1241-1243 |
, |
denotes |
, |
T21774 |
1243-1251 |
JJ |
denotes |
separate |
T21775 |
1252-1256 |
IN |
denotes |
from |
T21776 |
1257-1260 |
PRP$ |
denotes |
its |
T21777 |
1261-1265 |
NN |
denotes |
role |
T21778 |
1266-1268 |
IN |
denotes |
in |
T21779 |
1269-1273 |
NN |
denotes |
cell |
T21780 |
1274-1279 |
NN |
denotes |
cycle |
T21781 |
1280-1287 |
NN |
denotes |
control |
T21782 |
1287-1289 |
, |
denotes |
, |
T21783 |
1289-1291 |
NN |
denotes |
Rb |
T21784 |
1292-1302 |
NN |
denotes |
regulation |
T21785 |
1303-1305 |
IN |
denotes |
of |
T21786 |
1306-1311 |
NN |
denotes |
E2f3a |
T21787 |
1315-1323 |
JJ |
denotes |
critical |
T21788 |
1324-1326 |
TO |
denotes |
to |
T21789 |
1327-1333 |
VB |
denotes |
ensure |
T21790 |
1334-1340 |
JJ |
denotes |
proper |
T21791 |
1350-1365 |
NN |
denotes |
differentiation |
T21792 |
1341-1349 |
JJ |
denotes |
neuronal |
T21793 |
1365-1366 |
. |
denotes |
. |
R6326 |
T21495 |
T21496 |
aux |
To,test |
R6327 |
T21496 |
T21497 |
advcl |
test,exploited |
R6328 |
T21498 |
T21499 |
det |
which,isoform |
R6329 |
T21499 |
T21501 |
dep |
isoform,is |
R6330 |
T21500 |
T21499 |
compound |
E2f3,isoform |
R6331 |
T21501 |
T21496 |
ccomp |
is,test |
R6332 |
T21502 |
T21501 |
acomp |
responsible,is |
R6333 |
T21503 |
T21502 |
prep |
for,responsible |
R6334 |
T21504 |
T21505 |
amod |
aberrant,differentiation |
R6335 |
T21505 |
T21503 |
pobj |
differentiation,for |
R6336 |
T21506 |
T21507 |
compound |
Rb,KO |
R6337 |
T21507 |
T21505 |
compound |
KO,differentiation |
R6338 |
T21508 |
T21505 |
compound |
SAC,differentiation |
R6339 |
T21509 |
T21497 |
nsubj |
we,exploited |
R6340 |
T21510 |
T21511 |
nmod |
E2f3a,mice |
R6341 |
T21511 |
T21497 |
dobj |
mice,exploited |
R6342 |
T21512 |
T21510 |
punct |
−,E2f3a |
R6343 |
T21513 |
T21510 |
punct |
/,E2f3a |
R6344 |
T21514 |
T21510 |
punct |
−,E2f3a |
R6345 |
T21515 |
T21516 |
punct |
(,7A |
R6346 |
T21516 |
T21497 |
parataxis |
7A,exploited |
R6347 |
T21517 |
T21516 |
compound |
Figure,7A |
R6348 |
T21518 |
T21516 |
punct |
),7A |
R6349 |
T21519 |
T21497 |
punct |
.,exploited |
R6350 |
T21521 |
T21522 |
det |
The,strategy |
R6351 |
T21522 |
T21524 |
nsubjpass |
strategy,used |
R6352 |
T21523 |
T21522 |
compound |
genotyping,strategy |
R6353 |
T21525 |
T21522 |
acl |
outlined,strategy |
R6354 |
T21526 |
T21525 |
prep |
in,outlined |
R6355 |
T21527 |
T21528 |
compound |
Figure,7A |
R6356 |
T21528 |
T21526 |
pobj |
7A,in |
R6357 |
T21529 |
T21524 |
auxpass |
was,used |
R6358 |
T21530 |
T21531 |
aux |
to,distinguish |
R6359 |
T21531 |
T21524 |
advcl |
distinguish,used |
R6360 |
T21532 |
T21533 |
det |
the,alleles |
R6361 |
T21533 |
T21531 |
dobj |
alleles,distinguish |
R6362 |
T21534 |
T21533 |
nmod |
E2f3a,alleles |
R6363 |
T21535 |
T21534 |
punct |
", ",E2f3a |
R6364 |
T21536 |
T21534 |
conj |
WT,E2f3a |
R6365 |
T21537 |
T21536 |
punct |
", ",WT |
R6366 |
T21538 |
T21536 |
cc |
and,WT |
R6367 |
T21539 |
T21536 |
conj |
null,WT |
R6368 |
T21540 |
T21524 |
punct |
.,used |
R6369 |
T21542 |
T21543 |
amod |
Reverse,PCR |
R6370 |
T21543 |
T21545 |
nsubj |
PCR,confirmed |
R6371 |
T21544 |
T21543 |
compound |
transcriptase,PCR |
R6372 |
T21546 |
T21543 |
punct |
(,PCR |
R6373 |
T21547 |
T21548 |
compound |
RT,PCR |
R6374 |
T21548 |
T21543 |
appos |
PCR,PCR |
R6375 |
T21549 |
T21548 |
punct |
-,PCR |
R6376 |
T21550 |
T21545 |
punct |
),confirmed |
R6377 |
T21551 |
T21552 |
det |
the,presence |
R6378 |
T21552 |
T21545 |
dobj |
presence,confirmed |
R6379 |
T21553 |
T21552 |
prep |
of,presence |
R6380 |
T21554 |
T21555 |
preconj |
both,E2f3a |
R6381 |
T21555 |
T21556 |
nmod |
E2f3a,species |
R6382 |
T21556 |
T21553 |
pobj |
species,of |
R6383 |
T21557 |
T21555 |
cc |
and,E2f3a |
R6384 |
T21558 |
T21555 |
conj |
E2f3b,E2f3a |
R6385 |
T21559 |
T21556 |
compound |
RNA,species |
R6386 |
T21560 |
T21552 |
prep |
in,presence |
R6387 |
T21561 |
T21562 |
det |
the,retina |
R6388 |
T21562 |
T21560 |
pobj |
retina,in |
R6389 |
T21563 |
T21562 |
amod |
developing,retina |
R6390 |
T21564 |
T21562 |
compound |
WT,retina |
R6391 |
T21565 |
T21552 |
punct |
", ",presence |
R6392 |
T21566 |
T21552 |
cc |
and,presence |
R6393 |
T21567 |
T21568 |
det |
the,absence |
R6394 |
T21568 |
T21552 |
conj |
absence,presence |
R6395 |
T21569 |
T21568 |
amod |
specific,absence |
R6396 |
T21570 |
T21568 |
prep |
of,absence |
R6397 |
T21571 |
T21572 |
compound |
E2f3a,RNA |
R6398 |
T21572 |
T21570 |
pobj |
RNA,of |
R6399 |
T21573 |
T21568 |
prep |
in,absence |
R6400 |
T21574 |
T21575 |
det |
the,retina |
R6401 |
T21575 |
T21573 |
pobj |
retina,in |
R6402 |
T21576 |
T21575 |
nmod |
E2f3a,retina |
R6403 |
T21577 |
T21576 |
punct |
−,E2f3a |
R6404 |
T21578 |
T21576 |
punct |
/,E2f3a |
R6405 |
T21579 |
T21576 |
punct |
−,E2f3a |
R6406 |
T21580 |
T21581 |
punct |
(,7B |
R6407 |
T21581 |
T21545 |
parataxis |
7B,confirmed |
R6408 |
T21582 |
T21581 |
compound |
Figure,7B |
R6409 |
T21583 |
T21581 |
punct |
),7B |
R6410 |
T21584 |
T21545 |
punct |
.,confirmed |
R6411 |
T21586 |
T21587 |
compound |
E2f3a,protein |
R6412 |
T21587 |
T21588 |
nsubj |
protein,was |
R6413 |
T21589 |
T21588 |
acomp |
absent,was |
R6414 |
T21590 |
T21588 |
prep |
in,was |
R6415 |
T21591 |
T21592 |
nmod |
E2f3a,lysate |
R6416 |
T21592 |
T21590 |
pobj |
lysate,in |
R6417 |
T21593 |
T21591 |
punct |
−,E2f3a |
R6418 |
T21594 |
T21591 |
punct |
/,E2f3a |
R6419 |
T21595 |
T21591 |
punct |
−,E2f3a |
R6420 |
T21596 |
T21592 |
amod |
retinal,lysate |
R6421 |
T21597 |
T21598 |
punct |
(,S8 |
R6422 |
T21598 |
T21588 |
parataxis |
S8,was |
R6423 |
T21599 |
T21598 |
nmod |
Figures,S8 |
R6424 |
T21600 |
T21598 |
nummod |
6,S8 |
R6425 |
T21601 |
T21598 |
cc |
and,S8 |
R6426 |
T21602 |
T21598 |
punct |
),S8 |
R6427 |
T21603 |
T21588 |
punct |
.,was |
R6428 |
T21605 |
T21606 |
advmod |
Importantly,were |
R6429 |
T21607 |
T21606 |
punct |
", ",were |
R6430 |
T21608 |
T21609 |
det |
the,levels |
R6431 |
T21609 |
T21606 |
nsubj |
levels,were |
R6432 |
T21610 |
T21609 |
prep |
of,levels |
R6433 |
T21611 |
T21612 |
compound |
E2f3b,message |
R6434 |
T21612 |
T21610 |
pobj |
message,of |
R6435 |
T21613 |
T21606 |
acomp |
similar,were |
R6436 |
T21614 |
T21606 |
prep |
in,were |
R6437 |
T21615 |
T21616 |
det |
the,retina |
R6438 |
T21616 |
T21614 |
pobj |
retina,in |
R6439 |
T21617 |
T21618 |
nmod |
Rb,KO |
R6440 |
T21618 |
T21616 |
nmod |
KO,retina |
R6441 |
T21619 |
T21618 |
cc |
and,KO |
R6442 |
T21620 |
T21621 |
compound |
Rb,E2f3a |
R6443 |
T21621 |
T21623 |
compound |
E2f3a,DKO |
R6444 |
T21622 |
T21621 |
punct |
/,E2f3a |
R6445 |
T21623 |
T21618 |
conj |
DKO,KO |
R6446 |
T21624 |
T21606 |
punct |
", ",were |
R6447 |
T21625 |
T21606 |
advcl |
ruling,were |
R6448 |
T21626 |
T21625 |
prt |
out,ruling |
R6449 |
T21627 |
T21628 |
det |
the,possibility |
R6450 |
T21628 |
T21625 |
dobj |
possibility,ruling |
R6451 |
T21629 |
T21630 |
mark |
that,were |
R6452 |
T21630 |
T21628 |
acl |
were,possibility |
R6453 |
T21631 |
T21632 |
det |
any,effects |
R6454 |
T21632 |
T21630 |
nsubj |
effects,were |
R6455 |
T21633 |
T21632 |
prep |
of,effects |
R6456 |
T21634 |
T21635 |
compound |
E2f3a,deletion |
R6457 |
T21635 |
T21633 |
pobj |
deletion,of |
R6458 |
T21636 |
T21637 |
nsubj |
we,observe |
R6459 |
T21637 |
T21632 |
advcl |
observe,effects |
R6460 |
T21638 |
T21637 |
aux |
might,observe |
R6461 |
T21639 |
T21630 |
prep |
due,were |
R6462 |
T21640 |
T21639 |
pcomp |
to,due |
R6463 |
T21641 |
T21642 |
amod |
down,regulation |
R6464 |
T21642 |
T21639 |
pobj |
regulation,due |
R6465 |
T21643 |
T21642 |
punct |
-,regulation |
R6466 |
T21644 |
T21642 |
prep |
of,regulation |
R6467 |
T21645 |
T21644 |
pobj |
E2f3b,of |
R6468 |
T21646 |
T21647 |
punct |
(,7C |
R6469 |
T21647 |
T21630 |
parataxis |
7C,were |
R6470 |
T21648 |
T21647 |
compound |
Figure,7C |
R6471 |
T21649 |
T21647 |
punct |
),7C |
R6472 |
T21650 |
T21606 |
punct |
.,were |
R6473 |
T21652 |
T21653 |
advmod |
Also,were |
R6474 |
T21654 |
T21653 |
punct |
", ",were |
R6475 |
T21655 |
T21656 |
det |
the,levels |
R6476 |
T21656 |
T21653 |
nsubj |
levels,were |
R6477 |
T21657 |
T21656 |
prep |
of,levels |
R6478 |
T21658 |
T21659 |
amod |
other,E2fs |
R6479 |
T21659 |
T21657 |
pobj |
E2fs,of |
R6480 |
T21660 |
T21661 |
det |
the,same |
R6481 |
T21661 |
T21653 |
attr |
same,were |
R6482 |
T21662 |
T21661 |
prep |
in,same |
R6483 |
T21663 |
T21664 |
det |
the,retina |
R6484 |
T21664 |
T21662 |
pobj |
retina,in |
R6485 |
T21665 |
T21666 |
nmod |
Rb,KO |
R6486 |
T21666 |
T21664 |
nmod |
KO,retina |
R6487 |
T21667 |
T21666 |
punct |
", ",KO |
R6488 |
T21668 |
T21669 |
compound |
Rb,E2f3 |
R6489 |
T21669 |
T21671 |
compound |
E2f3,DKO |
R6490 |
T21670 |
T21669 |
punct |
/,E2f3 |
R6491 |
T21671 |
T21666 |
conj |
DKO,KO |
R6492 |
T21672 |
T21671 |
punct |
", ",DKO |
R6493 |
T21673 |
T21671 |
cc |
and,DKO |
R6494 |
T21674 |
T21675 |
compound |
Rb,E2f3a |
R6495 |
T21675 |
T21677 |
compound |
E2f3a,DKO |
R6496 |
T21676 |
T21675 |
punct |
/,E2f3a |
R6497 |
T21677 |
T21671 |
conj |
DKO,DKO |
R6498 |
T21678 |
T21653 |
punct |
", ",were |
R6499 |
T21679 |
T21653 |
advcl |
ruling,were |
R6500 |
T21680 |
T21679 |
prt |
out,ruling |
R6501 |
T21681 |
T21682 |
det |
any,effects |
R6502 |
T21682 |
T21679 |
dobj |
effects,ruling |
R6503 |
T21683 |
T21684 |
advmod |
cross,regulatory |
R6504 |
T21684 |
T21682 |
amod |
regulatory,effects |
R6505 |
T21685 |
T21684 |
punct |
-,regulatory |
R6506 |
T21686 |
T21687 |
punct |
(,7C |
R6507 |
T21687 |
T21653 |
parataxis |
7C,were |
R6508 |
T21688 |
T21687 |
compound |
Figure,7C |
R6509 |
T21689 |
T21687 |
punct |
),7C |
R6510 |
T21690 |
T21691 |
punct |
[,55 |
R6511 |
T21691 |
T21653 |
parataxis |
55,were |
R6512 |
T21692 |
T21691 |
punct |
],55 |
R6513 |
T21693 |
T21653 |
punct |
.,were |
R6514 |
T21695 |
T21696 |
nsubj |
E2f3a,trigger |
R6515 |
T21697 |
T21696 |
aux |
can,trigger |
R6516 |
T21698 |
T21699 |
compound |
cell,cycle |
R6517 |
T21699 |
T21700 |
compound |
cycle,induction |
R6518 |
T21700 |
T21696 |
dobj |
induction,trigger |
R6519 |
T21701 |
T21696 |
punct |
", ",trigger |
R6520 |
T21702 |
T21696 |
cc |
but,trigger |
R6521 |
T21703 |
T21704 |
mark |
because,linked |
R6522 |
T21704 |
T21709 |
advcl |
linked,suspected |
R6523 |
T21705 |
T21706 |
compound |
SAC,defects |
R6524 |
T21706 |
T21704 |
nsubjpass |
defects,linked |
R6525 |
T21707 |
T21704 |
auxpass |
are,linked |
R6526 |
T21708 |
T21704 |
neg |
not,linked |
R6527 |
T21709 |
T21696 |
conj |
suspected,trigger |
R6528 |
T21710 |
T21704 |
prep |
to,linked |
R6529 |
T21711 |
T21712 |
compound |
cell,cycle |
R6530 |
T21712 |
T21713 |
compound |
cycle,perturbation |
R6531 |
T21713 |
T21710 |
pobj |
perturbation,to |
R6532 |
T21714 |
T21715 |
punct |
(,3A |
R6533 |
T21715 |
T21704 |
parataxis |
3A,linked |
R6534 |
T21716 |
T21715 |
compound |
Figures,3A |
R6535 |
T21717 |
T21715 |
cc |
and,3A |
R6536 |
T21718 |
T21715 |
conj |
4,3A |
R6537 |
T21719 |
T21715 |
punct |
),3A |
R6538 |
T21720 |
T21704 |
punct |
", ",linked |
R6539 |
T21721 |
T21704 |
cc |
and,linked |
R6540 |
T21722 |
T21704 |
conj |
in,linked |
R6541 |
T21723 |
T21722 |
pobj |
view,in |
R6542 |
T21724 |
T21723 |
prep |
of,view |
R6543 |
T21725 |
T21726 |
det |
the,association |
R6544 |
T21726 |
T21724 |
pobj |
association,of |
R6545 |
T21727 |
T21726 |
amod |
predominant,association |
R6546 |
T21728 |
T21726 |
prep |
between,association |
R6547 |
T21729 |
T21728 |
pobj |
E2f3b,between |
R6548 |
T21730 |
T21729 |
cc |
and,E2f3b |
R6549 |
T21731 |
T21729 |
conj |
Rb,E2f3b |
R6550 |
T21732 |
T21726 |
prep |
in,association |
R6551 |
T21733 |
T21734 |
amod |
quiescent,cells |
R6552 |
T21734 |
T21732 |
pobj |
cells,in |
R6553 |
T21735 |
T21736 |
punct |
[,19 |
R6554 |
T21736 |
T21726 |
parataxis |
19,association |
R6555 |
T21737 |
T21736 |
nummod |
16,19 |
R6556 |
T21738 |
T21736 |
punct |
",",19 |
R6557 |
T21739 |
T21736 |
punct |
],19 |
R6558 |
T21740 |
T21709 |
punct |
", ",suspected |
R6559 |
T21741 |
T21709 |
nsubj |
we,suspected |
R6560 |
T21742 |
T21743 |
mark |
that,perturb |
R6561 |
T21743 |
T21709 |
ccomp |
perturb,suspected |
R6562 |
T21744 |
T21743 |
nsubj |
E2f3b,perturb |
R6563 |
T21745 |
T21743 |
aux |
may,perturb |
R6564 |
T21746 |
T21743 |
dobj |
differentiation,perturb |
R6565 |
T21747 |
T21743 |
prep |
in,perturb |
R6566 |
T21748 |
T21749 |
compound |
Rb,KO |
R6567 |
T21749 |
T21750 |
compound |
KO,SACs |
R6568 |
T21750 |
T21747 |
pobj |
SACs,in |
R6569 |
T21751 |
T21709 |
punct |
.,suspected |
R6570 |
T21753 |
T21754 |
advmod |
Unexpectedly,suppressed |
R6571 |
T21755 |
T21754 |
punct |
", ",suppressed |
R6572 |
T21756 |
T21754 |
advmod |
however,suppressed |
R6573 |
T21757 |
T21754 |
punct |
", ",suppressed |
R6574 |
T21758 |
T21759 |
compound |
E2f3a,deletion |
R6575 |
T21759 |
T21754 |
nsubj |
deletion,suppressed |
R6576 |
T21760 |
T21761 |
det |
the,defect |
R6577 |
T21761 |
T21754 |
dobj |
defect,suppressed |
R6578 |
T21762 |
T21763 |
compound |
Rb,KO |
R6579 |
T21763 |
T21761 |
compound |
KO,defect |
R6580 |
T21764 |
T21761 |
compound |
SAC,defect |
R6581 |
T21765 |
T21766 |
punct |
(,7D |
R6582 |
T21766 |
T21754 |
parataxis |
7D,suppressed |
R6583 |
T21767 |
T21766 |
compound |
Figure,7D |
R6584 |
T21768 |
T21766 |
punct |
),7D |
R6585 |
T21769 |
T21754 |
punct |
.,suppressed |
R6586 |
T21771 |
T21772 |
advmod |
Thus,is |
R6587 |
T21773 |
T21772 |
punct |
", ",is |
R6588 |
T21774 |
T21772 |
advcl |
separate,is |
R6589 |
T21775 |
T21774 |
prep |
from,separate |
R6590 |
T21776 |
T21777 |
poss |
its,role |
R6591 |
T21777 |
T21775 |
pobj |
role,from |
R6592 |
T21778 |
T21777 |
prep |
in,role |
R6593 |
T21779 |
T21780 |
compound |
cell,cycle |
R6594 |
T21780 |
T21781 |
compound |
cycle,control |
R6595 |
T21781 |
T21778 |
pobj |
control,in |
R6596 |
T21782 |
T21772 |
punct |
", ",is |
R6597 |
T21783 |
T21784 |
compound |
Rb,regulation |
R6598 |
T21784 |
T21772 |
nsubj |
regulation,is |
R6599 |
T21785 |
T21784 |
prep |
of,regulation |
R6600 |
T21786 |
T21785 |
pobj |
E2f3a,of |
R6601 |
T21787 |
T21772 |
acomp |
critical,is |
R6602 |
T21788 |
T21789 |
aux |
to,ensure |
R6603 |
T21789 |
T21772 |
advcl |
ensure,is |
R6604 |
T21790 |
T21791 |
amod |
proper,differentiation |
R6605 |
T21791 |
T21789 |
dobj |
differentiation,ensure |
R6606 |
T21792 |
T21791 |
amod |
neuronal,differentiation |
R6607 |
T21793 |
T21772 |
punct |
.,is |