PMC:1914394 / 36605-41678 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T20216	0-8	JJ	denotes	Distinct
T20217	9-21	NN	denotes	Localization
T20218	22-24	IN	denotes	of
T20219	25-29	NN	denotes	E2f3
T20220	30-38	NNS	denotes	Isoforms
T20221	38-136	sentence	denotes	As noted above, E2f3 and Rb staining in SACs was both nuclear and cytoplasmic (Figure 5A and 5B).
T20222	39-41	IN	denotes	As
T20223	42-47	VBN	denotes	noted
T20224	84-87	VBD	denotes	was
T20225	48-53	RB	denotes	above
T20226	53-55	,	denotes	,
T20227	55-59	NN	denotes	E2f3
T20228	67-75	NN	denotes	staining
T20229	60-63	CC	denotes	and
T20230	64-66	NN	denotes	Rb
T20231	76-78	IN	denotes	in
T20232	79-83	NNS	denotes	SACs
T20233	88-92	CC	denotes	both
T20234	93-100	JJ	denotes	nuclear
T20235	101-104	CC	denotes	and
T20236	105-116	JJ	denotes	cytoplasmic
T20237	117-118	-LRB-	denotes	(
T20238	125-127	NN	denotes	5A
T20239	118-124	NN	denotes	Figure
T20240	128-131	CC	denotes	and
T20241	132-134	NN	denotes	5B
T20242	134-135	-RRB-	denotes	)
T20243	135-136	.	denotes	.
T20244	136-255	sentence	denotes	The antibody that worked in immunostaining recognizes a C-terminal region and thus, does not distinguish a/b isoforms.
T20245	137-140	DT	denotes	The
T20246	141-149	NN	denotes	antibody
T20247	180-190	VBZ	denotes	recognizes
T20248	150-154	WDT	denotes	that
T20249	155-161	VBD	denotes	worked
T20250	162-164	IN	denotes	in
T20251	165-179	NN	denotes	immunostaining
T20252	191-192	DT	denotes	a
T20253	204-210	NN	denotes	region
T20254	193-194	NN	denotes	C
T20255	195-203	JJ	denotes	terminal
T20256	194-195	HYPH	denotes	-
T20257	211-214	CC	denotes	and
T20258	215-219	RB	denotes	thus
T20259	230-241	VB	denotes	distinguish
T20260	219-221	,	denotes	,
T20261	221-225	VBZ	denotes	does
T20262	226-229	RB	denotes	not
T20263	242-243	NN	denotes	a
T20264	244-245	NN	denotes	b
T20265	243-244	HYPH	denotes	/
T20266	246-254	NNS	denotes	isoforms
T20267	254-255	.	denotes	.
T20268	255-357	sentence	denotes	To our knowledge, the subcellular location of E2f3 isoforms has not been determined in any cell type.
T20269	256-258	IN	denotes	To
T20270	329-339	VBN	denotes	determined
T20271	259-262	PRP$	denotes	our
T20272	263-272	NN	denotes	knowledge
T20273	272-274	,	denotes	,
T20274	274-277	DT	denotes	the
T20275	290-298	NN	denotes	location
T20276	278-289	JJ	denotes	subcellular
T20277	299-301	IN	denotes	of
T20278	302-306	NN	denotes	E2f3
T20279	307-315	NNS	denotes	isoforms
T20280	316-319	VBZ	denotes	has
T20281	320-323	RB	denotes	not
T20282	324-328	VBN	denotes	been
T20283	340-342	IN	denotes	in
T20284	343-346	DT	denotes	any
T20285	352-356	NN	denotes	type
T20286	347-351	NN	denotes	cell
T20287	356-357	.	denotes	.
T20288	357-551	sentence	denotes	To verify the dual locations of E2f3 and to determine which isoforms were present in retina, we analyzed nuclear and cytoplasmic fractions by Western blot at different times during development.
T20289	358-360	TO	denotes	To
T20290	361-367	VB	denotes	verify
T20291	454-462	VBD	denotes	analyzed
T20292	368-371	DT	denotes	the
T20293	377-386	NNS	denotes	locations
T20294	372-376	JJ	denotes	dual
T20295	387-389	IN	denotes	of
T20296	390-394	NN	denotes	E2f3
T20297	395-398	CC	denotes	and
T20298	399-401	TO	denotes	to
T20299	402-411	VB	denotes	determine
T20300	412-417	WDT	denotes	which
T20301	418-426	NNS	denotes	isoforms
T20302	427-431	VBD	denotes	were
T20303	432-439	JJ	denotes	present
T20304	440-442	IN	denotes	in
T20305	443-449	NN	denotes	retina
T20306	449-451	,	denotes	,
T20307	451-453	PRP	denotes	we
T20308	463-470	JJ	denotes	nuclear
T20309	487-496	NNS	denotes	fractions
T20310	471-474	CC	denotes	and
T20311	475-486	JJ	denotes	cytoplasmic
T20312	497-499	IN	denotes	by
T20313	500-507	NNP	denotes	Western
T20314	508-512	NN	denotes	blot
T20315	513-515	IN	denotes	at
T20316	516-525	JJ	denotes	different
T20317	526-531	NNS	denotes	times
T20318	532-538	IN	denotes	during
T20319	539-550	NN	denotes	development
T20320	550-551	.	denotes	.
T20321	551-695	sentence	denotes	Analysis with the pan-E2f3 antibody (sc-878, Santa Cruz Biotechnology) detected a 55-kD E2f3a species and a 40-kD E2f3b polypeptide (Figure 6).
T20322	552-560	NN	denotes	Analysis
T20323	623-631	VBD	denotes	detected
T20324	561-565	IN	denotes	with
T20325	566-569	DT	denotes	the
T20326	579-587	NN	denotes	antibody
T20327	570-578	JJ	denotes	pan-E2f3
T20328	588-589	-LRB-	denotes	(
T20329	589-591	NN	denotes	sc
T20330	591-592	HYPH	denotes	-
T20331	592-595	CD	denotes	878
T20332	595-597	,	denotes	,
T20333	608-621	NNP	denotes	Biotechnology
T20334	597-602	NNP	denotes	Santa
T20335	603-607	NNP	denotes	Cruz
T20336	621-622	-RRB-	denotes	)
T20337	632-633	DT	denotes	a
T20338	646-653	NNS	denotes	species
T20339	634-636	CD	denotes	55
T20340	637-639	NN	denotes	kD
T20341	636-637	HYPH	denotes	-
T20342	640-645	NN	denotes	E2f3a
T20343	654-657	CC	denotes	and
T20344	658-659	DT	denotes	a
T20345	672-683	NN	denotes	polypeptide
T20346	660-662	CD	denotes	40
T20347	663-665	NN	denotes	kD
T20348	662-663	HYPH	denotes	-
T20349	666-671	NN	denotes	E2f3b
T20350	684-685	-LRB-	denotes	(
T20351	685-691	NN	denotes	Figure
T20352	692-693	CD	denotes	6
T20353	693-694	-RRB-	denotes	)
T20354	694-695	.	denotes	.
T20355	695-882	sentence	denotes	To confirm that the upper species in our retinal lysates was E2f3a, we exploited novel mice that lack E2f3 exon 1a and thus express E2f3b exclusively (R. O. and G. L., unpublished data).
T20356	696-698	TO	denotes	To
T20357	699-706	VB	denotes	confirm
T20358	767-776	VBD	denotes	exploited
T20359	707-711	IN	denotes	that
T20360	753-756	VBD	denotes	was
T20361	712-715	DT	denotes	the
T20362	722-729	NNS	denotes	species
T20363	716-721	JJ	denotes	upper
T20364	730-732	IN	denotes	in
T20365	733-736	PRP$	denotes	our
T20366	745-752	NNS	denotes	lysates
T20367	737-744	JJ	denotes	retinal
T20368	757-762	NN	denotes	E2f3a
T20369	762-764	,	denotes	,
T20370	764-766	PRP	denotes	we
T20371	777-782	JJ	denotes	novel
T20372	783-787	NNS	denotes	mice
T20373	788-792	WDT	denotes	that
T20374	793-797	VBP	denotes	lack
T20375	798-802	NN	denotes	E2f3
T20376	808-810	NN	denotes	1a
T20377	803-807	NN	denotes	exon
T20378	811-814	CC	denotes	and
T20379	815-819	RB	denotes	thus
T20380	820-827	VBP	denotes	express
T20381	828-833	NN	denotes	E2f3b
T20382	834-845	RB	denotes	exclusively
T20383	846-847	-LRB-	denotes	(
T20384	847-849	NNP	denotes	R.
T20385	850-852	NNP	denotes	O.
T20386	853-856	CC	denotes	and
T20387	857-859	NNP	denotes	G.
T20388	860-862	NNP	denotes	L.
T20389	862-864	,	denotes	,
T20390	864-875	JJ	denotes	unpublished
T20391	876-880	NNS	denotes	data
T20392	880-881	-RRB-	denotes	)
T20393	881-882	.	denotes	.
T20394	882-965	sentence	denotes	The genotyping strategy is discussed in detail later and is outlined in Figure 7A.
T20395	883-886	DT	denotes	The
T20396	898-906	NN	denotes	strategy
T20397	887-897	NN	denotes	genotyping
T20398	910-919	VBN	denotes	discussed
T20399	907-909	VBZ	denotes	is
T20400	920-922	IN	denotes	in
T20401	923-929	NN	denotes	detail
T20402	930-935	RB	denotes	later
T20403	936-939	CC	denotes	and
T20404	940-942	VBZ	denotes	is
T20405	943-951	VBN	denotes	outlined
T20406	952-954	IN	denotes	in
T20407	955-961	NN	denotes	Figure
T20408	962-964	NN	denotes	7A
T20410	965-1060	sentence	denotes	Western analysis confirmed that the upper band was absent in E2f3a−/− mice (Figures 6 and S8).
T20411	966-973	NNP	denotes	Western
T20412	974-982	NN	denotes	analysis
T20413	983-992	VBD	denotes	confirmed
T20414	993-997	IN	denotes	that
T20415	1013-1016	VBD	denotes	was
T20416	998-1001	DT	denotes	the
T20417	1008-1012	NN	denotes	band
T20418	1002-1007	JJ	denotes	upper
T20419	1017-1023	JJ	denotes	absent
T20420	1024-1026	IN	denotes	in
T20421	1027-1032	NN	denotes	E2f3a
T20422	1036-1040	NNS	denotes	mice
T20423	1032-1033	SYM	denotes	−
T20424	1033-1034	HYPH	denotes	/
T20425	1034-1035	SYM	denotes	−
T20426	1041-1042	-LRB-	denotes	(
T20427	1056-1058	NN	denotes	S8
T20428	1042-1049	NNS	denotes	Figures
T20429	1050-1051	CD	denotes	6
T20430	1052-1055	CC	denotes	and
T20431	1058-1059	-RRB-	denotes	)
T20432	1059-1060	.	denotes	.
T20433	1060-1221	sentence	denotes	Consistent with the drop in E2f3-expressing cells during WT retinal maturation (Figure 5A), the total amount of E2f3a was less at P18 compared to P0 (Figure 6).
T20434	1061-1071	JJ	denotes	Consistent
T20435	1179-1182	VBD	denotes	was
T20436	1072-1076	IN	denotes	with
T20437	1077-1080	DT	denotes	the
T20438	1081-1085	NN	denotes	drop
T20439	1086-1088	IN	denotes	in
T20440	1089-1093	NN	denotes	E2f3
T20441	1094-1104	VBG	denotes	expressing
T20442	1093-1094	HYPH	denotes	-
T20443	1105-1110	NNS	denotes	cells
T20444	1111-1117	IN	denotes	during
T20445	1118-1120	NN	denotes	WT
T20446	1129-1139	NN	denotes	maturation
T20447	1121-1128	JJ	denotes	retinal
T20448	1140-1141	-LRB-	denotes	(
T20449	1148-1150	NN	denotes	5A
T20450	1141-1147	NN	denotes	Figure
T20451	1150-1151	-RRB-	denotes	)
T20452	1151-1153	,	denotes	,
T20453	1153-1156	DT	denotes	the
T20454	1163-1169	NN	denotes	amount
T20455	1157-1162	JJ	denotes	total
T20456	1170-1172	IN	denotes	of
T20457	1173-1178	NN	denotes	E2f3a
T20458	1183-1187	JJR	denotes	less
T20459	1188-1190	IN	denotes	at
T20460	1191-1194	NN	denotes	P18
T20461	1195-1203	VBN	denotes	compared
T20462	1204-1206	IN	denotes	to
T20463	1207-1209	NN	denotes	P0
T20464	1210-1211	-LRB-	denotes	(
T20465	1211-1217	NN	denotes	Figure
T20466	1218-1219	CD	denotes	6
T20467	1219-1220	-RRB-	denotes	)
T20468	1220-1221	.	denotes	.
T20469	1221-1279	sentence	denotes	E2f3b was present in similar amounts at both time points.
T20470	1222-1227	NN	denotes	E2f3b
T20471	1228-1231	VBD	denotes	was
T20472	1232-1239	JJ	denotes	present
T20473	1240-1242	IN	denotes	in
T20474	1243-1250	JJ	denotes	similar
T20475	1251-1258	NNS	denotes	amounts
T20476	1259-1261	IN	denotes	at
T20477	1262-1266	DT	denotes	both
T20478	1272-1278	NNS	denotes	points
T20479	1267-1271	NN	denotes	time
T20480	1278-1279	.	denotes	.
T20481	1279-1435	sentence	denotes	At P0 and P18, E2f3a was present in both nuclear and cytoplasmic fractions, but in marked contrast, E2f3b was exclusively nuclear at both times (Figure 6).
T20482	1280-1282	IN	denotes	At
T20483	1301-1304	VBD	denotes	was
T20484	1283-1285	NN	denotes	P0
T20485	1286-1289	CC	denotes	and
T20486	1290-1293	NN	denotes	P18
T20487	1293-1295	,	denotes	,
T20488	1295-1300	NN	denotes	E2f3a
T20489	1305-1312	JJ	denotes	present
T20490	1313-1315	IN	denotes	in
T20491	1316-1320	CC	denotes	both
T20492	1321-1328	JJ	denotes	nuclear
T20493	1345-1354	NNS	denotes	fractions
T20494	1329-1332	CC	denotes	and
T20495	1333-1344	JJ	denotes	cytoplasmic
T20496	1354-1356	,	denotes	,
T20497	1356-1359	CC	denotes	but
T20498	1360-1362	IN	denotes	in
T20499	1386-1389	VBD	denotes	was
T20500	1363-1369	JJ	denotes	marked
T20501	1370-1378	NN	denotes	contrast
T20502	1378-1380	,	denotes	,
T20503	1380-1385	NN	denotes	E2f3b
T20504	1390-1401	RB	denotes	exclusively
T20505	1402-1409	JJ	denotes	nuclear
T20506	1410-1412	IN	denotes	at
T20507	1413-1417	DT	denotes	both
T20508	1418-1423	NNS	denotes	times
T20509	1424-1425	-LRB-	denotes	(
T20510	1425-1431	NN	denotes	Figure
T20511	1432-1433	CD	denotes	6
T20512	1433-1434	-RRB-	denotes	)
T20513	1434-1435	.	denotes	.
T20514	1435-1636	sentence	denotes	Two closely migrating E2f3a bands were detected, more clearly evident at P18, of which the faster migrating species was dominant in nuclear and the slower species was dominant in cytoplasm (Figure 6).
T20515	1436-1439	CD	denotes	Two
T20516	1464-1469	NNS	denotes	bands
T20517	1440-1447	RB	denotes	closely
T20518	1448-1457	VBG	denotes	migrating
T20519	1458-1463	NN	denotes	E2f3a
T20520	1475-1483	VBN	denotes	detected
T20521	1470-1474	VBD	denotes	were
T20522	1483-1485	,	denotes	,
T20523	1485-1489	RBR	denotes	more
T20524	1490-1497	RB	denotes	clearly
T20525	1498-1505	JJ	denotes	evident
T20526	1506-1508	IN	denotes	at
T20527	1509-1512	NN	denotes	P18
T20528	1512-1514	,	denotes	,
T20529	1514-1516	IN	denotes	of
T20530	1552-1555	VBD	denotes	was
T20531	1517-1522	WDT	denotes	which
T20532	1523-1526	DT	denotes	the
T20533	1544-1551	NN	denotes	species
T20534	1527-1533	RBR	denotes	faster
T20535	1534-1543	VBG	denotes	migrating
T20536	1556-1564	JJ	denotes	dominant
T20537	1565-1567	IN	denotes	in
T20538	1568-1575	JJ	denotes	nuclear
T20539	1576-1579	CC	denotes	and
T20540	1580-1583	DT	denotes	the
T20541	1591-1598	NN	denotes	species
T20542	1584-1590	JJR	denotes	slower
T20543	1599-1602	VBD	denotes	was
T20544	1603-1611	JJ	denotes	dominant
T20545	1612-1614	IN	denotes	in
T20546	1615-1624	NN	denotes	cytoplasm
T20547	1625-1626	-LRB-	denotes	(
T20548	1626-1632	NN	denotes	Figure
T20549	1633-1634	CD	denotes	6
T20550	1634-1635	-RRB-	denotes	)
T20551	1635-1636	.	denotes	.
T20552	1636-1745	sentence	denotes	The identity of both as E2f3a species was confirmed by their absence in the P18 E2f3a KO retina (Figure S8).
T20553	1637-1640	DT	denotes	The
T20554	1641-1649	NN	denotes	identity
T20555	1679-1688	VBN	denotes	confirmed
T20556	1650-1652	IN	denotes	of
T20557	1653-1657	DT	denotes	both
T20558	1658-1660	IN	denotes	as
T20559	1661-1666	NN	denotes	E2f3a
T20560	1667-1674	NNS	denotes	species
T20561	1675-1678	VBD	denotes	was
T20562	1689-1691	IN	denotes	by
T20563	1692-1697	PRP$	denotes	their
T20564	1698-1705	NN	denotes	absence
T20565	1706-1708	IN	denotes	in
T20566	1709-1712	DT	denotes	the
T20567	1726-1732	NN	denotes	retina
T20568	1713-1716	NN	denotes	P18
T20569	1717-1722	NN	denotes	E2f3a
T20570	1723-1725	NN	denotes	KO
T20571	1733-1734	-LRB-	denotes	(
T20572	1741-1743	NN	denotes	S8
T20573	1734-1740	NN	denotes	Figure
T20574	1743-1744	-RRB-	denotes	)
T20575	1744-1745	.	denotes	.
T20576	1745-2013	sentence	denotes	Analysis of Pou4f2, a nuclear transcription factor expressed in ganglion cells, showed that nuclear proteins had not contaminated the cytoplasmic fraction, and analysis of Slc18a3, a cytoplasmic SAC marker, confirmed that the reverse had also not occurred (Figure 6).
T20577	1746-1754	NN	denotes	Analysis
T20578	1826-1832	VBD	denotes	showed
T20579	1755-1757	IN	denotes	of
T20580	1758-1764	NN	denotes	Pou4f2
T20581	1764-1766	,	denotes	,
T20582	1766-1767	DT	denotes	a
T20583	1790-1796	NN	denotes	factor
T20584	1768-1775	JJ	denotes	nuclear
T20585	1776-1789	NN	denotes	transcription
T20586	1797-1806	VBN	denotes	expressed
T20587	1807-1809	IN	denotes	in
T20588	1810-1818	NN	denotes	ganglion
T20589	1819-1824	NNS	denotes	cells
T20590	1824-1826	,	denotes	,
T20591	1833-1837	IN	denotes	that
T20592	1863-1875	VBN	denotes	contaminated
T20593	1838-1845	JJ	denotes	nuclear
T20594	1846-1854	NN	denotes	proteins
T20595	1855-1858	VBD	denotes	had
T20596	1859-1862	RB	denotes	not
T20597	1876-1879	DT	denotes	the
T20598	1892-1900	NN	denotes	fraction
T20599	1880-1891	JJ	denotes	cytoplasmic
T20600	1900-1902	,	denotes	,
T20601	1902-1905	CC	denotes	and
T20602	1906-1914	NN	denotes	analysis
T20603	1953-1962	VBD	denotes	confirmed
T20604	1915-1917	IN	denotes	of
T20605	1918-1925	NN	denotes	Slc18a3
T20606	1925-1927	,	denotes	,
T20607	1927-1928	DT	denotes	a
T20608	1945-1951	NN	denotes	marker
T20609	1929-1940	JJ	denotes	cytoplasmic
T20610	1941-1944	NN	denotes	SAC
T20611	1951-1953	,	denotes	,
T20612	1963-1967	IN	denotes	that
T20613	1993-2001	VBN	denotes	occurred
T20614	1968-1971	DT	denotes	the
T20615	1972-1979	NN	denotes	reverse
T20616	1980-1983	VBD	denotes	had
T20617	1984-1988	RB	denotes	also
T20618	1989-1992	RB	denotes	not
T20619	2002-2003	-LRB-	denotes	(
T20716	4361-4362	-RRB-	denotes	)
T20717	4362-4363	.	denotes	.
T20718	4363-4548	sentence	denotes	A very faint cytoplasmic Rb signal was evident at P18, which is consistent with Rb staining of SAC processes (Figure 5B), and with the very small proportion of SACs in the retina [38].
T20719	4364-4365	DT	denotes	A
T20720	4392-4398	NN	denotes	signal
T20721	4366-4370	RB	denotes	very
T20722	4371-4376	JJ	denotes	faint
T20723	4377-4388	JJ	denotes	cytoplasmic
T20724	4389-4391	NN	denotes	Rb
T20725	4399-4402	VBD	denotes	was
T20726	4403-4410	JJ	denotes	evident
T20727	4411-4413	IN	denotes	at
T20728	4414-4417	NN	denotes	P18
T20729	4417-4419	,	denotes	,
T20730	4419-4424	WDT	denotes	which
T20731	4425-4427	VBZ	denotes	is
T20732	4428-4438	JJ	denotes	consistent
T20733	4439-4443	IN	denotes	with
T20734	4444-4446	NN	denotes	Rb
T20735	4447-4455	NN	denotes	staining
T20736	4456-4458	IN	denotes	of
T20737	4459-4462	NN	denotes	SAC
T20738	4463-4472	NNS	denotes	processes
T20739	4473-4474	-LRB-	denotes	(
T20740	4481-4483	NN	denotes	5B
T20741	4474-4480	NN	denotes	Figure
T20742	4483-4484	-RRB-	denotes	)
T20743	4484-4486	,	denotes	,
T20744	4486-4489	CC	denotes	and
T20745	4490-4494	IN	denotes	with
T20746	4495-4498	DT	denotes	the
T20747	4510-4520	NN	denotes	proportion
T20748	4499-4503	RB	denotes	very
T20749	4504-4509	JJ	denotes	small
T20750	4521-4523	IN	denotes	of
T20751	4524-4528	NNS	denotes	SACs
T20752	4529-4531	IN	denotes	in
T20753	4532-4535	DT	denotes	the
T20754	4536-4542	NN	denotes	retina
T20755	4543-4544	-LRB-	denotes	[
T20756	4544-4546	CD	denotes	38
T20757	4546-4547	-RRB-	denotes	]
T20758	4547-4548	.	denotes	.
T20759	4548-4696	sentence	denotes	E2f1 was also detected in both nuclear and cytoplasmic fractions, although unlike E2f3a it was predominantly nuclear both at P0 and P18 (Figure 6).
T20760	4549-4553	NN	denotes	E2f1
T20761	4563-4571	VBN	denotes	detected
T20762	4554-4557	VBD	denotes	was
T20763	4558-4562	RB	denotes	also
T20764	4572-4574	IN	denotes	in
T20765	4575-4579	CC	denotes	both
T20766	4580-4587	JJ	denotes	nuclear
T20767	4604-4613	NNS	denotes	fractions
T20768	4588-4591	CC	denotes	and
T20769	4592-4603	JJ	denotes	cytoplasmic
T20770	4613-4615	,	denotes	,
T20771	4615-4623	IN	denotes	although
T20772	4640-4643	VBD	denotes	was
T20773	4624-4630	IN	denotes	unlike
T20774	4631-4636	NN	denotes	E2f3a
T20775	4637-4639	PRP	denotes	it
T20776	4644-4657	RB	denotes	predominantly
T20777	4658-4665	JJ	denotes	nuclear
T20778	4666-4670	CC	denotes	both
T20779	4671-4673	IN	denotes	at
T20780	4674-4676	NN	denotes	P0
T20781	4677-4680	CC	denotes	and
T20782	4681-4684	NN	denotes	P18
T20783	4685-4686	-LRB-	denotes	(
T20784	4686-4692	NN	denotes	Figure
T20785	4693-4694	CD	denotes	6
T20786	4694-4695	-RRB-	denotes	)
T20787	4695-4696	.	denotes	.
T20788	4696-4921	sentence	denotes	The E2f dimerization partner, Tfdp1, which lacks a nuclear localization signal [54], was primarily cytoplasmic at both P0 and P18, and the Cdk inhibitors Cdkn1a and Cdkn1b showed a similar pattern of distribution (Figure 6).
T20789	4697-4700	DT	denotes	The
T20790	4718-4725	NN	denotes	partner
T20791	4701-4704	NN	denotes	E2f
T20792	4705-4717	NN	denotes	dimerization
T20793	4782-4785	VBD	denotes	was
T20794	4725-4727	,	denotes	,
T20795	4727-4732	NN	denotes	Tfdp1
T20796	4732-4734	,	denotes	,
T20797	4734-4739	WDT	denotes	which
T20798	4740-4745	VBZ	denotes	lacks
T20799	4746-4747	DT	denotes	a
T20800	4769-4775	NN	denotes	signal
T20801	4748-4755	JJ	denotes	nuclear
T20802	4756-4768	NN	denotes	localization
T20803	4776-4777	-LRB-	denotes	[
T20804	4777-4779	CD	denotes	54
T20805	4779-4780	-RRB-	denotes	]
T20806	4780-4782	,	denotes	,
T20807	4786-4795	RB	denotes	primarily
T20808	4796-4807	JJ	denotes	cytoplasmic
T20809	4808-4810	IN	denotes	at
T20810	4811-4815	CC	denotes	both
T20811	4816-4818	NN	denotes	P0
T20812	4819-4822	CC	denotes	and
T20813	4823-4826	NN	denotes	P18
T20814	4826-4828	,	denotes	,
T20815	4828-4831	CC	denotes	and
T20816	4832-4835	DT	denotes	the
T20817	4840-4850	NNS	denotes	inhibitors
T20818	4836-4839	NN	denotes	Cdk
T20819	4869-4875	VBD	denotes	showed
T20820	4851-4857	NN	denotes	Cdkn1a
T20821	4858-4861	CC	denotes	and
T20822	4862-4868	NN	denotes	Cdkn1b
T20823	4876-4877	DT	denotes	a
T20824	4886-4893	NN	denotes	pattern
T20825	4878-4885	JJ	denotes	similar
T20826	4894-4896	IN	denotes	of
T20827	4897-4909	NN	denotes	distribution
T20828	4910-4911	-LRB-	denotes	(
T20829	4911-4917	NN	denotes	Figure
T20830	4918-4919	CD	denotes	6
T20831	4919-4920	-RRB-	denotes	)
T20832	4920-4921	.	denotes	.
T20833	4921-5073	sentence	denotes	Thus, among the cell cycle regulators we examined, most showed bivalent distribution, and E2f3b was unusual in its solely nuclear compartmentalization.
T20834	4922-4926	RB	denotes	Thus
T20835	4978-4984	VBD	denotes	showed
T20836	4926-4928	,	denotes	,
T20837	4928-4933	IN	denotes	among
T20838	4934-4937	DT	denotes	the
T20839	4949-4959	NNS	denotes	regulators
T20840	4938-4942	NN	denotes	cell
T20841	4943-4948	NN	denotes	cycle
T20842	4960-4962	PRP	denotes	we
T20843	4963-4971	VBD	denotes	examined
T20844	4971-4973	,	denotes	,
T20845	4973-4977	JJS	denotes	most
T20846	4985-4993	JJ	denotes	bivalent
T20847	4994-5006	NN	denotes	distribution
T20848	5006-5008	,	denotes	,
T20849	5008-5011	CC	denotes	and
T20850	5012-5017	NN	denotes	E2f3b
T20851	5018-5021	VBD	denotes	was
T20852	5022-5029	JJ	denotes	unusual
T20853	5030-5032	IN	denotes	in
T20854	5033-5036	PRP$	denotes	its
T20855	5052-5072	NN	denotes	compartmentalization
T20856	5037-5043	RB	denotes	solely
T20857	5044-5051	JJ	denotes	nuclear
T20858	5072-5073	.	denotes	.
T37145	2273-2284	JJ	denotes	Subcellular
T37146	2285-2297	NN	denotes	Distribution
T37147	2298-2300	IN	denotes	of
T37148	2301-2305	NN	denotes	E2f3
T37149	2306-2314	NNS	denotes	Isoforms
T37150	2315-2318	CC	denotes	and
T37151	2319-2324	JJ	denotes	Other
T37152	2336-2344	NNS	denotes	Proteins
T37153	2325-2329	NN	denotes	Cell
T37154	2330-2335	NN	denotes	Cycle
T37155	2345-2347	IN	denotes	in
T37156	2348-2351	DT	denotes	the
T37157	2363-2369	NN	denotes	Retina
T37158	2352-2362	VBG	denotes	Developing
T37159	2369-2559	sentence	denotes	Nuclear and cytoplasmic extracts from an equivalent number of retinal cells from mice of the indicated genotypes and ages were analyzed by Western blotting to detect the indicated proteins.
T37160	2370-2377	JJ	denotes	Nuclear
T37161	2394-2402	NNS	denotes	extracts
T37162	2378-2381	CC	denotes	and
T37163	2382-2393	JJ	denotes	cytoplasmic
T37164	2497-2505	VBN	denotes	analyzed
T37165	2403-2407	IN	denotes	from
T37166	2408-2410	DT	denotes	an
T37167	2422-2428	NN	denotes	number
T37168	2411-2421	JJ	denotes	equivalent
T37169	2429-2431	IN	denotes	of
T37170	2432-2439	JJ	denotes	retinal
T37171	2440-2445	NNS	denotes	cells
T37172	2446-2450	IN	denotes	from
T37173	2451-2455	NNS	denotes	mice
T37174	2456-2458	IN	denotes	of
T37175	2459-2462	DT	denotes	the
T37176	2473-2482	NNS	denotes	genotypes
T37177	2463-2472	VBN	denotes	indicated
T37178	2483-2486	CC	denotes	and
T37179	2487-2491	NNS	denotes	ages
T37180	2492-2496	VBD	denotes	were
T37181	2506-2508	IN	denotes	by
T37182	2509-2516	NNP	denotes	Western
T37183	2517-2525	NN	denotes	blotting
T37184	2526-2528	TO	denotes	to
T37185	2529-2535	VB	denotes	detect
T37186	2536-2539	DT	denotes	the
T37187	2550-2558	NN	denotes	proteins
T37188	2540-2549	VBN	denotes	indicated
T37189	2558-2559	.	denotes	.
T37190	2559-2649	sentence	denotes	Lysate from E2f3a−/− mice was used as a control to confirm the location of E2f3a protein.
T37191	2560-2566	NN	denotes	Lysate
T37192	2590-2594	VBN	denotes	used
T37193	2567-2571	IN	denotes	from
T37194	2572-2577	NN	denotes	E2f3a
T37195	2581-2585	NNS	denotes	mice
T37196	2577-2578	SYM	denotes	−
T37197	2578-2579	HYPH	denotes	/
T37198	2579-2580	SYM	denotes	−
T37199	2586-2589	VBD	denotes	was
T37200	2595-2597	IN	denotes	as
T37201	2598-2599	DT	denotes	a
T37202	2600-2607	NN	denotes	control
T37203	2608-2610	TO	denotes	to
T37204	2611-2618	VB	denotes	confirm
T37205	2619-2622	DT	denotes	the
T37206	2623-2631	NN	denotes	location
T37207	2632-2634	IN	denotes	of
T37208	2635-2640	NN	denotes	E2f3a
T37209	2641-2648	NN	denotes	protein
T37210	2648-2649	.	denotes	.
T37211	2649-2695	sentence	denotes	C, cytoplasmic extracts; N, nuclear extracts.
T37212	2650-2651	NN	denotes	C
T37213	2651-2653	,	denotes	,
T37214	2653-2664	JJ	denotes	cytoplasmic
T37215	2665-2673	NNS	denotes	extracts
T37216	2673-2674	:	denotes	;
T37217	2675-2676	NN	denotes	N
T37218	2676-2678	,	denotes	,
T37219	2678-2685	JJ	denotes	nuclear
T37220	2686-2694	NNS	denotes	extracts
T37221	2694-2695	.	denotes	.
T37919	2731-2734	DT	denotes	the
T37920	2751-2757	NN	denotes	Defect
T37921	2735-2750	NN	denotes	Differentiation
T37922	2758-2760	IN	denotes	in
T37923	2761-2763	NN	denotes	Rb
T37915	2706-2709	DT	denotes	The
T37916	2716-2723	NN	denotes	Isoform
T37917	2710-2715	NN	denotes	E2f3a
T37918	2724-2730	VBZ	denotes	Drives
T37924	2764-2766	NN	denotes	KO
T37925	2767-2771	NNS	denotes	SACs
T37926	2771-2905	sentence	denotes	(A) Schematic diagrams of the mouse WT, E2f3a−/−, and the Cre-recombined floxed E2f3 loci (indicated here as E2f3−/− for simplicity).
T37927	2772-2773	-LRB-	denotes	(
T37928	2773-2774	LS	denotes	A
T37929	2786-2794	NNS	denotes	diagrams
T37930	2774-2775	-RRB-	denotes	)
T37931	2776-2785	JJ	denotes	Schematic
T37932	2795-2797	IN	denotes	of
T37933	2798-2801	DT	denotes	the
T37934	2808-2810	NN	denotes	WT
T37935	2802-2807	NN	denotes	mouse
T37936	2810-2812	,	denotes	,
T37937	2812-2817	NN	denotes	E2f3a
T37938	2817-2818	SYM	denotes	−
T37939	2818-2819	HYPH	denotes	/
T37940	2819-2820	SYM	denotes	−
T37941	2820-2822	,	denotes	,
T37942	2822-2825	CC	denotes	and
T37943	2826-2829	DT	denotes	the
T37944	2857-2861	NNS	denotes	loci
T37945	2830-2833	NN	denotes	Cre
T37946	2833-2834	HYPH	denotes	-
T37947	2834-2844	VBN	denotes	recombined
T37948	2845-2851	VBN	denotes	floxed
T37949	2852-2856	NN	denotes	E2f3
T37950	2862-2863	-LRB-	denotes	(
T37951	2863-2872	VBN	denotes	indicated
T37952	2873-2877	RB	denotes	here
T37953	2878-2880	IN	denotes	as
T37954	2881-2885	NN	denotes	E2f3
T37955	2885-2886	SYM	denotes	−
T37956	2886-2887	HYPH	denotes	/
T37957	2887-2888	SYM	denotes	−
T37958	2889-2892	IN	denotes	for
T37959	2893-2903	NN	denotes	simplicity
T37960	2903-2904	-RRB-	denotes	)
T37961	2904-2905	.	denotes	.
T37962	2905-2985	sentence	denotes	E2f3a−/− mice lack most of E2f3 exon 1a and part of intron 1a (red dotted box).
T37963	2906-2911	NN	denotes	E2f3a
T37964	2915-2919	NNS	denotes	mice
T37965	2911-2912	SYM	denotes	−
T37966	2912-2913	HYPH	denotes	/
T37967	2913-2914	SYM	denotes	−
T37968	2920-2924	VBP	denotes	lack
T37969	2925-2929	JJS	denotes	most
T37970	2930-2932	IN	denotes	of
T37971	2933-2937	NN	denotes	E2f3
T37972	2943-2945	NN	denotes	1a
T37973	2938-2942	NN	denotes	exon
T37974	2946-2949	CC	denotes	and
T37975	2950-2954	NN	denotes	part
T37976	2955-2957	IN	denotes	of
T37977	2958-2964	NN	denotes	intron
T37978	2965-2967	NN	denotes	1a
T37979	2968-2969	-LRB-	denotes	(
T37980	2980-2983	NN	denotes	box
T37981	2969-2972	JJ	denotes	red
T37982	2973-2979	VBN	denotes	dotted
T37983	2983-2984	-RRB-	denotes	)
T37984	2984-2985	.	denotes	.
T37985	2985-3014	sentence	denotes	Arrows indicate PCR primers.
T37986	2986-2992	NNS	denotes	Arrows
T37987	2993-3001	VBP	denotes	indicate
T37988	3002-3005	NN	denotes	PCR
T37989	3006-3013	NNS	denotes	primers
T37990	3013-3014	.	denotes	.
T37991	3014-3069	sentence	denotes	Genotyping of an E2f3a+/− mouse is shown on the right.
T37992	3015-3025	NN	denotes	Genotyping
T37993	3050-3055	VBN	denotes	shown
T37994	3026-3028	IN	denotes	of
T37995	3029-3031	DT	denotes	an
T37996	3041-3046	NN	denotes	mouse
T37997	3032-3037	NN	denotes	E2f3a
T37998	3037-3038	SYM	denotes	+
T37999	3038-3039	HYPH	denotes	/
T38000	3039-3040	SYM	denotes	−
T38001	3047-3049	VBZ	denotes	is
T38002	3056-3058	IN	denotes	on
T38003	3059-3062	DT	denotes	the
T38004	3063-3068	NN	denotes	right
T38005	3068-3069	.	denotes	.
T38006	3069-3129	sentence	denotes	(B) RT-PCR detection of E2f3a and E2f3b mRNA in the retina.
T38007	3070-3071	-LRB-	denotes	(
T38008	3071-3072	LS	denotes	B
T38009	3081-3090	NN	denotes	detection
T38010	3072-3073	-RRB-	denotes	)
T38011	3074-3076	NN	denotes	RT
T38012	3077-3080	NN	denotes	PCR
T38013	3076-3077	HYPH	denotes	-
T38014	3091-3093	IN	denotes	of
T38015	3094-3099	NN	denotes	E2f3a
T38016	3110-3114	NN	denotes	mRNA
T38017	3100-3103	CC	denotes	and
T38018	3104-3109	NN	denotes	E2f3b
T38019	3115-3117	IN	denotes	in
T38020	3118-3121	DT	denotes	the
T38021	3122-3128	NN	denotes	retina
T38022	3128-3129	.	denotes	.
T38023	3129-3263	sentence	denotes	The sequences of primers are 1aF (5′-GCCTCTACACCACGCCACAAG-3′), 1bF (5′-CGGAAATGCCCTTACAGC-3′), and 4R (5′-CTCAGTCACTTCTTTGGACAG-3′).
T38024	3130-3133	DT	denotes	The
T38025	3134-3143	NNS	denotes	sequences
T38026	3155-3158	VBP	denotes	are
T38027	3144-3146	IN	denotes	of
T38028	3147-3154	NNS	denotes	primers
T38029	3159-3162	NN	denotes	1aF
T38030	3163-3164	-LRB-	denotes	(
T38031	3164-3165	CD	denotes	5
T38032	3167-3188	NN	denotes	GCCTCTACACCACGCCACAAG
T38033	3165-3166	SYM	denotes	′
T38034	3166-3167	HYPH	denotes	-
T38035	3188-3189	HYPH	denotes	-
T38036	3189-3190	CD	denotes	3
T38037	3190-3191	SYM	denotes	′
T38038	3191-3192	-RRB-	denotes	)
T38039	3192-3194	,	denotes	,
T38040	3194-3197	NN	denotes	1bF
T38041	3198-3199	-LRB-	denotes	(
T38042	3199-3200	CD	denotes	5
T38043	3202-3220	NN	denotes	CGGAAATGCCCTTACAGC
T38044	3200-3201	SYM	denotes	′
T38045	3201-3202	HYPH	denotes	-
T38046	3220-3221	HYPH	denotes	-
T38047	3221-3222	CD	denotes	3
T38048	3222-3223	SYM	denotes	′
T38049	3223-3224	-RRB-	denotes	)
T38050	3224-3226	,	denotes	,
T38051	3226-3229	CC	denotes	and
T38052	3230-3232	NN	denotes	4R
T38053	3233-3234	-LRB-	denotes	(
T38054	3234-3235	CD	denotes	5
T38055	3237-3258	NN	denotes	CTCAGTCACTTCTTTGGACAG
T38056	3235-3236	SYM	denotes	′
T38057	3236-3237	HYPH	denotes	-
T38058	3258-3259	HYPH	denotes	-
T38059	3259-3260	CD	denotes	3
T38060	3260-3261	SYM	denotes	′
T38061	3261-3262	-RRB-	denotes	)
T38062	3262-3263	.	denotes	.
T38063	3263-3310	sentence	denotes	WT retina expresses both E2f3a and E2f3b mRNA.
T38064	3264-3266	NN	denotes	WT
T38065	3267-3273	NN	denotes	retina
T38066	3274-3283	VBZ	denotes	expresses
T38067	3284-3288	CC	denotes	both
T38068	3289-3294	NN	denotes	E2f3a
T38069	3305-3309	NN	denotes	mRNA
T38070	3295-3298	CC	denotes	and
T38071	3299-3304	NN	denotes	E2f3b
T38072	3309-3310	.	denotes	.
T38073	3310-3388	sentence	denotes	As expected, E2f3a−/− retina lacks E2f3a mRNA and still expresses E2f3b mRNA.
T38074	3311-3313	IN	denotes	As
T38075	3314-3322	VBN	denotes	expected
T38076	3340-3345	VBZ	denotes	lacks
T38077	3322-3324	,	denotes	,
T38078	3324-3329	NN	denotes	E2f3a
T38079	3333-3339	NN	denotes	retina
T38080	3329-3330	SYM	denotes	−
T38081	3330-3331	HYPH	denotes	/
T38082	3331-3332	SYM	denotes	−
T38083	3346-3351	NN	denotes	E2f3a
T38084	3352-3356	NN	denotes	mRNA
T38085	3357-3360	CC	denotes	and
T38086	3361-3366	RB	denotes	still
T38087	3367-3376	VBZ	denotes	expresses
T38088	3377-3382	NN	denotes	E2f3b
T38089	3383-3387	NN	denotes	mRNA
T38090	3387-3388	.	denotes	.
T38091	3388-3499	sentence	denotes	E2f3−/− retina lacks full-length E2f3a and E2f3b mRNAs, and instead expresses a truncated mRNA lacking exon 3.
T38092	3389-3393	NN	denotes	E2f3
T38093	3397-3403	NN	denotes	retina
T38094	3393-3394	SYM	denotes	−
T38095	3394-3395	HYPH	denotes	/
T38096	3395-3396	SYM	denotes	−
T38097	3404-3409	VBZ	denotes	lacks
T38098	3410-3414	JJ	denotes	full
T38099	3415-3421	NN	denotes	length
T38100	3414-3415	HYPH	denotes	-
T38101	3438-3443	NNS	denotes	mRNAs
T38102	3422-3427	NN	denotes	E2f3a
T38103	3428-3431	CC	denotes	and
T38104	3432-3437	NN	denotes	E2f3b
T38105	3443-3445	,	denotes	,
T38106	3445-3448	CC	denotes	and
T38107	3449-3456	RB	denotes	instead
T38108	3457-3466	VBZ	denotes	expresses
T38109	3467-3468	DT	denotes	a
T38110	3479-3483	NN	denotes	mRNA
T38111	3469-3478	VBN	denotes	truncated
T38112	3484-3491	VBG	denotes	lacking
T38113	3492-3496	NN	denotes	exon
T38114	3497-3498	CD	denotes	3
T38115	3498-3499	.	denotes	.
T38116	3499-3584	sentence	denotes	(C) Real-time RT-PCR analysis of E2f genes in P8 retinas of the indicated genotypes.
T38117	3500-3501	-LRB-	denotes	(
T38118	3501-3502	LS	denotes	C
T38119	3521-3529	NN	denotes	analysis
T38120	3502-3503	-RRB-	denotes	)
T38121	3504-3508	JJ	denotes	Real
T38122	3509-3513	NN	denotes	time
T38123	3508-3509	HYPH	denotes	-
T38124	3514-3516	NN	denotes	RT
T38125	3517-3520	NN	denotes	PCR
T38126	3516-3517	HYPH	denotes	-
T38127	3530-3532	IN	denotes	of
T38128	3533-3536	NN	denotes	E2f
T38129	3537-3542	NNS	denotes	genes
T38130	3543-3545	IN	denotes	in
T38131	3546-3548	NN	denotes	P8
T38132	3549-3556	NNS	denotes	retinas
T38133	3557-3559	IN	denotes	of
T38134	3560-3563	DT	denotes	the
T38135	3574-3583	NNS	denotes	genotypes
T38136	3564-3573	VBN	denotes	indicated
T38137	3583-3584	.	denotes	.
T38138	3584-3784	sentence	denotes	Error bars represent SD of measurements from three animals, and asterisks indicate a significant difference between WT and the indicated genotypes (, p <0.05; *; p <0.01; ANOVA and Tukey HSD test).
T38139	3585-3590	NN	denotes	Error
T38140	3591-3595	NNS	denotes	bars
T38141	3596-3605	VBP	denotes	represent
T38142	3606-3608	NN	denotes	SD
T38143	3609-3611	IN	denotes	of
T38144	3612-3624	NNS	denotes	measurements
T38145	3625-3629	IN	denotes	from
T38146	3630-3635	CD	denotes	three
T38147	3636-3643	NNS	denotes	animals
T38148	3643-3645	,	denotes	,
T38149	3645-3648	CC	denotes	and
T38150	3649-3658	NNS	denotes	asterisks
T38151	3659-3667	VBP	denotes	indicate
T38152	3668-3669	DT	denotes	a
T38153	3682-3692	NN	denotes	difference
T38154	3670-3681	JJ	denotes	significant
T38155	3693-3700	IN	denotes	between
T38156	3701-3703	NN	denotes	WT
T38157	3704-3707	CC	denotes	and
T38158	3708-3711	DT	denotes	the
T38159	3712-3721	VBN	denotes	indicated
T38160	3722-3731	NNS	denotes	genotypes
T38161	3732-3733	-LRB-	denotes	(
T38162	3778-3782	NN	denotes	test
T38163	3733-3734	SYM	denotes	*
T38164	3739-3743	CD	denotes	0.05
T38165	3734-3736	,	denotes	,
T38166	3736-3737	NN	denotes	p
T38167	3738-3739	SYM	denotes	<
T38168	3743-3744	:	denotes	;
T38169	3745-3747	SYM	denotes	**
T38170	3752-3756	CD	denotes	0.01
T38171	3747-3748	:	denotes	;
T38172	3749-3750	NN	denotes	p
T38173	3751-3752	SYM	denotes	<
T38174	3756-3757	:	denotes	;
T38175	3758-3763	NN	denotes	ANOVA
T38176	3764-3767	CC	denotes	and
T38177	3768-3773	NNP	denotes	Tukey
T38178	3774-3777	NN	denotes	HSD
T38179	3782-3783	-RRB-	denotes	)
T38180	3783-3784	.	denotes	.
T38181	3784-3828	sentence	denotes	(D) Rescue of Rb KO SACs by E2f3a deletion.
T38182	3785-3786	-LRB-	denotes	(
T38183	3786-3787	LS	denotes	D
T38184	3789-3795	NN	denotes	Rescue
T38185	3787-3788	-RRB-	denotes	)
T38186	3796-3798	IN	denotes	of
T38187	3799-3801	NN	denotes	Rb
T38188	3802-3804	NN	denotes	KO
T38189	3805-3809	NNS	denotes	SACs
T38190	3810-3812	IN	denotes	by
T38191	3813-3818	NN	denotes	E2f3a
T38192	3819-3827	NN	denotes	deletion
T38193	3827-3828	.	denotes	.
T38194	3828-3986	sentence	denotes	Horizontal retinal sections of the indicated genotypes and ages were stained for nuclei (DAPI, blue), M-phase (PH3, green), and the SAC marker Slc18a3 (red).
T38195	3829-3839	JJ	denotes	Horizontal
T38196	3848-3856	NNS	denotes	sections
T38197	3840-3847	JJ	denotes	retinal
T38198	3898-3905	VBN	denotes	stained
T38199	3857-3859	IN	denotes	of
T38200	3860-3863	DT	denotes	the
T38201	3874-3883	NNS	denotes	genotypes
T38202	3864-3873	VBN	denotes	indicated
T38203	3884-3887	CC	denotes	and
T38204	3888-3892	NNS	denotes	ages
T38205	3893-3897	VBD	denotes	were
T38206	3906-3909	IN	denotes	for
T38207	3910-3916	NNS	denotes	nuclei
T38208	3917-3918	-LRB-	denotes	(
T38209	3924-3928	JJ	denotes	blue
T38210	3918-3922	NN	denotes	DAPI
T38211	3922-3924	,	denotes	,
T38212	3928-3929	-RRB-	denotes	)
T38213	3929-3931	,	denotes	,
T38214	3931-3932	NN	denotes	M
T38215	3933-3938	NN	denotes	phase
T38216	3932-3933	HYPH	denotes	-
T38217	3939-3940	-LRB-	denotes	(
T38218	3945-3950	JJ	denotes	green
T38219	3940-3943	NN	denotes	PH3
T38220	3943-3945	,	denotes	,
T38221	3950-3951	-RRB-	denotes	)
T38222	3951-3953	,	denotes	,
T38223	3953-3956	CC	denotes	and
T38224	3957-3960	DT	denotes	the
T38225	3965-3971	NN	denotes	marker
T38226	3961-3964	NN	denotes	SAC
T38227	3972-3979	NN	denotes	Slc18a3
T38228	3980-3981	-LRB-	denotes	(
T38229	3981-3984	JJ	denotes	red
T38230	3984-3985	-RRB-	denotes	)
T38231	3985-3986	.	denotes	.
T38232	3986-4065	sentence	denotes	E2f3a deletion does not suppress ectopic division, but rescues the SAC defect.
T38233	3987-3992	NN	denotes	E2f3a
T38234	3993-4001	NN	denotes	deletion
T38235	4011-4019	VB	denotes	suppress
T38236	4002-4006	VBZ	denotes	does
T38237	4007-4010	RB	denotes	not
T38238	4020-4027	JJ	denotes	ectopic
T38239	4028-4036	NN	denotes	division
T38240	4036-4038	,	denotes	,
T38241	4038-4041	CC	denotes	but
T38242	4042-4049	VBZ	denotes	rescues
T38243	4050-4053	DT	denotes	the
T38244	4058-4064	NN	denotes	defect
T38245	4054-4057	NN	denotes	SAC
T38246	4064-4065	.	denotes	.
T38247	4065-4087	sentence	denotes	Scale bars are 50 μm.
T38248	4066-4071	NN	denotes	Scale
T38249	4072-4076	NNS	denotes	bars
T38250	4077-4080	VBP	denotes	are
T38251	4081-4083	CD	denotes	50
T38252	4084-4086	NN	denotes	μm
T38253	4086-4087	.	denotes	.
T38254	4087-4113	sentence	denotes	M, molecular size marker.
T38255	4088-4089	NN	denotes	M
T38256	4089-4091	,	denotes	,
T38257	4091-4100	JJ	denotes	molecular
T38258	4101-4105	NN	denotes	size
T38259	4106-4112	NN	denotes	marker
T38260	4112-4113	.	denotes	.
T20626	2020-2024	NNS	denotes	data
T20627	2025-2029	VBP	denotes	show
T20628	2029-2031	,	denotes	,
T20629	2031-2033	IN	denotes	to
T20630	2048-2051	IN	denotes	for
T20631	2034-2037	PRP$	denotes	our
T20632	2038-2047	NN	denotes	knowledge
T20633	2052-2055	DT	denotes	the
T20634	2062-2066	NN	denotes	time
T20635	2056-2061	JJ	denotes	first
T20636	2066-2068	,	denotes	,
T20637	2068-2072	IN	denotes	that
T20638	2089-2096	VBP	denotes	exhibit
T20639	2073-2078	NN	denotes	E2f3a
T20640	2079-2082	CC	denotes	and
T20641	2083-2088	NN	denotes	E2f3b
T20642	2097-2105	JJ	denotes	distinct
T20643	2106-2114	NNS	denotes	patterns
T20644	2115-2117	IN	denotes	of
T20645	2118-2129	JJ	denotes	subcellular
T20646	2130-2142	NN	denotes	distribution
T20647	2142-2144	,	denotes	,
T20648	2144-2147	CC	denotes	and
T20649	2148-2153	VB	denotes	raise
T20650	2154-2157	DT	denotes	the
T20651	2158-2169	NN	denotes	possibility
T20652	2170-2174	IN	denotes	that
T20653	2201-2210	VBN	denotes	regulated
T20654	2175-2180	NN	denotes	E2f3a
T20655	2181-2193	NN	denotes	localization
T20656	2194-2197	MD	denotes	may
T20657	2198-2200	VB	denotes	be
T20658	2211-2213	IN	denotes	by
T20659	2214-2216	RB	denotes	as
T20660	2217-2220	RB	denotes	yet
T20661	2221-2228	JJ	denotes	unknown
T20662	2248-2261	NNS	denotes	modifications
T20663	2229-2247	JJ	denotes	post-translational
T20664	2261-2262	.	denotes	.
T20695	4274-4276	NN	denotes	P0
T20696	4276-4278	,	denotes	,
T20697	4278-4281	CC	denotes	but
T20698	4282-4284	IN	denotes	at
T20699	4330-4333	VBD	denotes	was
T20700	4285-4288	NN	denotes	P18
T20701	4288-4290	,	denotes	,
T20702	4290-4294	WRB	denotes	when
T20703	4316-4325	VBN	denotes	increased
T20704	4295-4298	DT	denotes	the
T20705	4299-4305	NNS	denotes	levels
T20706	4306-4308	IN	denotes	of
T20707	4309-4311	NN	denotes	Rb
T20708	4312-4315	VBD	denotes	had
T20709	4325-4327	,	denotes	,
T20710	4327-4329	PRP	denotes	it
T20711	4334-4343	RB	denotes	primarily
T20712	4344-4351	JJ	denotes	nuclear
T20713	4352-4353	-LRB-	denotes	(
T20714	4353-4359	NN	denotes	Figure
T20715	4360-4361	CD	denotes	6
T20409	964-965	.	denotes	.
T20620	2003-2009	NN	denotes	Figure
T20621	2010-2011	CD	denotes	6
T20622	2011-2012	-RRB-	denotes	)
T20623	2012-2013	.	denotes	.
T20624	2013-2262	sentence	denotes	These data show, to our knowledge for the first time, that E2f3a and E2f3b exhibit distinct patterns of subcellular distribution, and raise the possibility that E2f3a localization may be regulated by as yet unknown post-translational modifications.
T20625	2014-2019	DT	denotes	These
T20665	2262-4206	sentence	denotes	Figure 6 Subcellular Distribution of E2f3 Isoforms and Other Cell Cycle Proteins in the Developing Retina Nuclear and cytoplasmic extracts from an equivalent number of retinal cells from mice of the indicated genotypes and ages were analyzed by Western blotting to detect the indicated proteins. Lysate from E2f3a−/− mice was used as a control to confirm the location of E2f3a protein. C, cytoplasmic extracts; N, nuclear extracts. Figure 7 The E2f3a Isoform Drives the Differentiation Defect in Rb KO SACs (A) Schematic diagrams of the mouse WT, E2f3a−/−, and the Cre-recombined floxed E2f3 loci (indicated here as E2f3−/− for simplicity). E2f3a−/− mice lack most of E2f3 exon 1a and part of intron 1a (red dotted box). Arrows indicate PCR primers. Genotyping of an E2f3a+/− mouse is shown on the right. (B) RT-PCR detection of E2f3a and E2f3b mRNA in the retina. The sequences of primers are 1aF (5′-GCCTCTACACCACGCCACAAG-3′), 1bF (5′-CGGAAATGCCCTTACAGC-3′), and 4R (5′-CTCAGTCACTTCTTTGGACAG-3′). WT retina expresses both E2f3a and E2f3b mRNA. As expected, E2f3a−/− retina lacks E2f3a mRNA and still expresses E2f3b mRNA. E2f3−/− retina lacks full-length E2f3a and E2f3b mRNAs, and instead expresses a truncated mRNA lacking exon 3. (C) Real-time RT-PCR analysis of E2f genes in P8 retinas of the indicated genotypes. Error bars represent SD of measurements from three animals, and asterisks indicate a significant difference between WT and the indicated genotypes (, p <0.05; *; p <0.01; ANOVA and Tukey HSD test). (D) Rescue of Rb KO SACs by E2f3a deletion. Horizontal retinal sections of the indicated genotypes and ages were stained for nuclei (DAPI, blue), M-phase (PH3, green), and the SAC marker Slc18a3 (red). E2f3a deletion does not suppress ectopic division, but rescues the SAC defect. Scale bars are 50 μm. M, molecular size marker. We also examined the distribution of other cell cycle regulators during retinal development.
T20666	4114-4116	PRP	denotes	We
T20667	4122-4130	VBD	denotes	examined
T20668	4117-4121	RB	denotes	also
T20669	4131-4134	DT	denotes	the
T20670	4135-4147	NN	denotes	distribution
T20671	4148-4150	IN	denotes	of
T20672	4151-4156	JJ	denotes	other
T20673	4168-4178	NNS	denotes	regulators
T20674	4157-4161	NN	denotes	cell
T20675	4162-4167	NN	denotes	cycle
T20676	4179-4185	IN	denotes	during
T20677	4186-4193	JJ	denotes	retinal
T20678	4194-4205	NN	denotes	development
T20679	4205-4206	.	denotes	.
T20680	4206-4363	sentence	denotes	Like E2f3a, Rb was present in both the WT cytoplasm and nucleus at P0, but at P18, when the levels of Rb had increased, it was primarily nuclear (Figure 6).
T20681	4207-4211	IN	denotes	Like
T20682	4222-4225	VBD	denotes	was
T20683	4212-4217	NN	denotes	E2f3a
T20684	4217-4219	,	denotes	,
T20685	4219-4221	NN	denotes	Rb
T20686	4226-4233	JJ	denotes	present
T20687	4234-4236	IN	denotes	in
T20688	4237-4241	CC	denotes	both
T20689	4249-4258	NN	denotes	cytoplasm
T20690	4242-4245	DT	denotes	the
T20691	4246-4248	NN	denotes	WT
T20692	4259-4262	CC	denotes	and
T20693	4263-4270	NN	denotes	nucleus
T20694	4271-4273	IN	denotes	at
R5721	T20216	T20217	amod	Distinct,Localization
R5722	T20218	T20217	prep	of,Localization
R5723	T20219	T20220	compound	E2f3,Isoforms
R5724	T20220	T20218	pobj	Isoforms,of
R5725	T20222	T20223	mark	As,noted
R5726	T20223	T20224	advcl	noted,was
R5727	T20225	T20223	advmod	above,noted
R5728	T20226	T20224	punct	", ",was
R5729	T20227	T20228	nmod	E2f3,staining
R5730	T20228	T20224	nsubj	staining,was
R5731	T20229	T20227	cc	and,E2f3
R5732	T20230	T20227	conj	Rb,E2f3
R5733	T20231	T20228	prep	in,staining
R5734	T20232	T20231	pobj	SACs,in
R5735	T20233	T20234	preconj	both,nuclear
R5736	T20234	T20224	acomp	nuclear,was
R5737	T20235	T20234	cc	and,nuclear
R5738	T20236	T20234	conj	cytoplasmic,nuclear
R5739	T20237	T20238	punct	(,5A
R5740	T20238	T20224	parataxis	5A,was
R5741	T20239	T20238	compound	Figure,5A
R5742	T20240	T20238	cc	and,5A
R5743	T20241	T20238	conj	5B,5A
R5744	T20242	T20238	punct	),5A
R5745	T20243	T20224	punct	.,was
R5746	T20245	T20246	det	The,antibody
R5747	T20246	T20247	nsubj	antibody,recognizes
R5748	T20248	T20249	dep	that,worked
R5749	T20249	T20246	relcl	worked,antibody
R5750	T20250	T20249	prep	in,worked
R5751	T20251	T20250	pobj	immunostaining,in
R5752	T20252	T20253	det	a,region
R5753	T20253	T20247	dobj	region,recognizes
R5754	T20254	T20255	npadvmod	C,terminal
R5755	T20255	T20253	amod	terminal,region
R5756	T20256	T20255	punct	-,terminal
R5757	T20257	T20247	cc	and,recognizes
R5758	T20258	T20259	advmod	thus,distinguish
R5759	T20259	T20247	conj	distinguish,recognizes
R5760	T20260	T20259	punct	", ",distinguish
R5761	T20261	T20259	aux	does,distinguish
R5762	T20262	T20259	neg	not,distinguish
R5763	T20263	T20264	compound	a,b
R5764	T20264	T20266	compound	b,isoforms
R5765	T20265	T20264	punct	/,b
R5766	T20266	T20259	dobj	isoforms,distinguish
R5767	T20267	T20247	punct	.,recognizes
R5768	T20269	T20270	prep	To,determined
R5769	T20271	T20272	poss	our,knowledge
R5770	T20272	T20269	pobj	knowledge,To
R5771	T20273	T20270	punct	", ",determined
R5772	T20274	T20275	det	the,location
R5773	T20275	T20270	nsubjpass	location,determined
R5774	T20276	T20275	amod	subcellular,location
R5775	T20277	T20275	prep	of,location
R5776	T20278	T20279	compound	E2f3,isoforms
R5777	T20279	T20277	pobj	isoforms,of
R5778	T20280	T20270	aux	has,determined
R5779	T20281	T20270	neg	not,determined
R5780	T20282	T20270	auxpass	been,determined
R5781	T20283	T20270	prep	in,determined
R5782	T20284	T20285	det	any,type
R5783	T20285	T20283	pobj	type,in
R5784	T20286	T20285	compound	cell,type
R5785	T20287	T20270	punct	.,determined
R5786	T20289	T20290	aux	To,verify
R5787	T20290	T20291	advcl	verify,analyzed
R5788	T20292	T20293	det	the,locations
R5789	T20293	T20290	dobj	locations,verify
R5790	T20294	T20293	amod	dual,locations
R5791	T20295	T20293	prep	of,locations
R5792	T20296	T20295	pobj	E2f3,of
R5793	T20297	T20290	cc	and,verify
R5794	T20298	T20299	aux	to,determine
R5795	T20299	T20290	conj	determine,verify
R5796	T20300	T20301	det	which,isoforms
R5797	T20301	T20302	dep	isoforms,were
R5798	T20302	T20299	ccomp	were,determine
R5799	T20303	T20302	acomp	present,were
R5800	T20304	T20302	prep	in,were
R5801	T20305	T20304	pobj	retina,in
R5802	T20306	T20291	punct	", ",analyzed
R5803	T20307	T20291	nsubj	we,analyzed
R5804	T20308	T20309	amod	nuclear,fractions
R5805	T20309	T20291	dobj	fractions,analyzed
R5806	T20310	T20308	cc	and,nuclear
R5807	T20311	T20308	conj	cytoplasmic,nuclear
R5808	T20312	T20291	prep	by,analyzed
R5809	T20313	T20314	compound	Western,blot
R5810	T20314	T20312	pobj	blot,by
R5811	T20315	T20291	prep	at,analyzed
R5812	T20316	T20317	amod	different,times
R5813	T20317	T20315	pobj	times,at
R5814	T20318	T20317	prep	during,times
R5815	T20319	T20318	pobj	development,during
R5816	T20320	T20291	punct	.,analyzed
R5817	T20322	T20323	nsubj	Analysis,detected
R5818	T20324	T20322	prep	with,Analysis
R5819	T20325	T20326	det	the,antibody
R5820	T20326	T20324	pobj	antibody,with
R5821	T20327	T20326	amod	pan-E2f3,antibody
R5822	T20328	T20326	punct	(,antibody
R5823	T20329	T20326	appos	sc,antibody
R5824	T20330	T20329	punct	-,sc
R5825	T20331	T20329	nummod	878,sc
R5826	T20332	T20333	punct	", ",Biotechnology
R5827	T20333	T20326	parataxis	Biotechnology,antibody
R5828	T20334	T20335	compound	Santa,Cruz
R5829	T20335	T20333	compound	Cruz,Biotechnology
R5830	T20336	T20333	punct	),Biotechnology
R5831	T20337	T20338	det	a,species
R5832	T20338	T20323	dobj	species,detected
R5833	T20339	T20340	nummod	55,kD
R5834	T20340	T20338	compound	kD,species
R5835	T20341	T20340	punct	-,kD
R5836	T20342	T20338	compound	E2f3a,species
R5837	T20343	T20338	cc	and,species
R5838	T20344	T20345	det	a,polypeptide
R5839	T20345	T20338	conj	polypeptide,species
R5840	T20346	T20347	nummod	40,kD
R5841	T20347	T20345	compound	kD,polypeptide
R5842	T20348	T20347	punct	-,kD
R5843	T20349	T20345	compound	E2f3b,polypeptide
R5844	T20350	T20351	punct	(,Figure
R5845	T20351	T20323	parataxis	Figure,detected
R5846	T20352	T20351	nummod	6,Figure
R5847	T20353	T20351	punct	),Figure
R5848	T20354	T20323	punct	.,detected
R5849	T20356	T20357	aux	To,confirm
R5850	T20357	T20358	advcl	confirm,exploited
R5851	T20359	T20360	mark	that,was
R5852	T20360	T20357	ccomp	was,confirm
R5853	T20361	T20362	det	the,species
R5854	T20362	T20360	nsubj	species,was
R5855	T20363	T20362	amod	upper,species
R5856	T20364	T20362	prep	in,species
R5857	T20365	T20366	poss	our,lysates
R5858	T20366	T20364	pobj	lysates,in
R5859	T20367	T20366	amod	retinal,lysates
R5860	T20368	T20360	attr	E2f3a,was
R5861	T20369	T20358	punct	", ",exploited
R5862	T20370	T20358	nsubj	we,exploited
R5863	T20371	T20372	amod	novel,mice
R5864	T20372	T20358	dobj	mice,exploited
R5865	T20373	T20374	dep	that,lack
R5866	T20374	T20372	relcl	lack,mice
R5867	T20375	T20376	compound	E2f3,1a
R5868	T20376	T20374	dobj	1a,lack
R5869	T20377	T20376	compound	exon,1a
R5870	T20378	T20374	cc	and,lack
R5871	T20379	T20380	advmod	thus,express
R5872	T20380	T20374	conj	express,lack
R5873	T20381	T20380	dobj	E2f3b,express
R5874	T20382	T20380	advmod	exclusively,express
R5875	T20383	T20384	punct	(,R.
R5876	T20384	T20380	meta	R.,express
R5877	T20385	T20384	nmod	O.,R.
R5878	T20386	T20384	cc	and,R.
R5879	T20387	T20384	conj	G.,R.
R5880	T20388	T20387	nmod	L.,G.
R5881	T20389	T20387	punct	", ",G.
R5882	T20390	T20391	amod	unpublished,data
R5883	T20391	T20387	conj	data,G.
R5884	T20392	T20391	punct	),data
R5885	T20393	T20358	punct	.,exploited
R5886	T20395	T20396	det	The,strategy
R5887	T20396	T20398	nsubjpass	strategy,discussed
R5888	T20397	T20396	compound	genotyping,strategy
R5889	T20399	T20398	auxpass	is,discussed
R5890	T20400	T20398	prep	in,discussed
R5891	T20401	T20400	pobj	detail,in
R5892	T20402	T20398	advmod	later,discussed
R5893	T20403	T20398	cc	and,discussed
R5894	T20404	T20405	auxpass	is,outlined
R5895	T20405	T20398	conj	outlined,discussed
R5896	T20406	T20405	prep	in,outlined
R5897	T20407	T20408	compound	Figure,7A
R5898	T20408	T20406	pobj	7A,in
R5899	T20409	T20398	punct	.,discussed
R5900	T20411	T20412	compound	Western,analysis
R5901	T20412	T20413	nsubj	analysis,confirmed
R5902	T20414	T20415	mark	that,was
R5903	T20415	T20413	ccomp	was,confirmed
R5904	T20416	T20417	det	the,band
R5905	T20417	T20415	nsubj	band,was
R5906	T20418	T20417	amod	upper,band
R5907	T20419	T20415	acomp	absent,was
R5908	T20420	T20415	prep	in,was
R5909	T20421	T20422	nmod	E2f3a,mice
R5910	T20422	T20420	pobj	mice,in
R5911	T20423	T20421	punct	−,E2f3a
R5912	T20424	T20421	punct	/,E2f3a
R5913	T20425	T20421	punct	−,E2f3a
R5914	T20426	T20427	punct	(,S8
R5915	T20427	T20413	parataxis	S8,confirmed
R5916	T20428	T20427	nmod	Figures,S8
R5917	T20429	T20427	nummod	6,S8
R5918	T20430	T20427	cc	and,S8
R5919	T20431	T20427	punct	),S8
R5920	T20432	T20413	punct	.,confirmed
R5921	T20434	T20435	advcl	Consistent,was
R5922	T20436	T20434	prep	with,Consistent
R5923	T20437	T20438	det	the,drop
R5924	T20438	T20436	pobj	drop,with
R5925	T20439	T20438	prep	in,drop
R5926	T20440	T20441	npadvmod	E2f3,expressing
R5927	T20441	T20443	amod	expressing,cells
R5928	T20442	T20441	punct	-,expressing
R5929	T20443	T20439	pobj	cells,in
R5930	T20444	T20438	prep	during,drop
R5931	T20445	T20446	nmod	WT,maturation
R5932	T20446	T20444	pobj	maturation,during
R5933	T20447	T20446	amod	retinal,maturation
R5934	T20448	T20449	punct	(,5A
R5935	T20449	T20438	parataxis	5A,drop
R5936	T20450	T20449	compound	Figure,5A
R5937	T20451	T20449	punct	),5A
R5938	T20452	T20435	punct	", ",was
R5939	T20453	T20454	det	the,amount
R5940	T20454	T20435	nsubj	amount,was
R5941	T20455	T20454	amod	total,amount
R5942	T20456	T20454	prep	of,amount
R5943	T20457	T20456	pobj	E2f3a,of
R5944	T20458	T20435	acomp	less,was
R5945	T20459	T20435	prep	at,was
R5946	T20460	T20459	pobj	P18,at
R5947	T20461	T20435	prep	compared,was
R5948	T20462	T20461	prep	to,compared
R5949	T20463	T20462	pobj	P0,to
R5950	T20464	T20465	punct	(,Figure
R5951	T20465	T20435	parataxis	Figure,was
R5952	T20466	T20465	nummod	6,Figure
R5953	T20467	T20465	punct	),Figure
R5954	T20468	T20435	punct	.,was
R5955	T20470	T20471	nsubj	E2f3b,was
R5956	T20472	T20471	acomp	present,was
R5957	T20473	T20471	prep	in,was
R5958	T20474	T20475	amod	similar,amounts
R5959	T20475	T20473	pobj	amounts,in
R5960	T20476	T20471	prep	at,was
R5961	T20477	T20478	det	both,points
R5962	T20478	T20476	pobj	points,at
R5963	T20479	T20478	compound	time,points
R5964	T20480	T20471	punct	.,was
R5965	T20482	T20483	prep	At,was
R5966	T20484	T20482	pobj	P0,At
R5967	T20485	T20484	cc	and,P0
R5968	T20486	T20484	conj	P18,P0
R5969	T20487	T20483	punct	", ",was
R5970	T20488	T20483	nsubj	E2f3a,was
R5971	T20489	T20483	acomp	present,was
R5972	T20490	T20483	prep	in,was
R5973	T20491	T20492	preconj	both,nuclear
R5974	T20492	T20493	amod	nuclear,fractions
R5975	T20493	T20490	pobj	fractions,in
R5976	T20494	T20492	cc	and,nuclear
R5977	T20495	T20492	conj	cytoplasmic,nuclear
R5978	T20496	T20483	punct	", ",was
R5979	T20497	T20483	cc	but,was
R5980	T20498	T20499	prep	in,was
R5981	T20499	T20483	conj	was,was
R5982	T20500	T20501	amod	marked,contrast
R5983	T20501	T20498	pobj	contrast,in
R5984	T20502	T20499	punct	", ",was
R5985	T20503	T20499	nsubj	E2f3b,was
R5986	T20504	T20505	advmod	exclusively,nuclear
R5987	T20505	T20499	acomp	nuclear,was
R5988	T20506	T20499	prep	at,was
R5989	T20507	T20508	det	both,times
R5990	T20508	T20506	pobj	times,at
R5991	T20509	T20510	punct	(,Figure
R5992	T20510	T20499	parataxis	Figure,was
R5993	T20511	T20510	nummod	6,Figure
R5994	T20512	T20510	punct	),Figure
R5995	T20513	T20499	punct	.,was
R5996	T20515	T20516	nummod	Two,bands
R5997	T20516	T20520	nsubjpass	bands,detected
R5998	T20517	T20518	advmod	closely,migrating
R5999	T20518	T20516	amod	migrating,bands
R6000	T20519	T20516	compound	E2f3a,bands
R6001	T20521	T20520	auxpass	were,detected
R6002	T20522	T20520	punct	", ",detected
R6003	T20523	T20524	advmod	more,clearly
R6004	T20524	T20525	advmod	clearly,evident
R6005	T20525	T20520	advcl	evident,detected
R6006	T20526	T20525	prep	at,evident
R6007	T20527	T20526	pobj	P18,at
R6008	T20528	T20520	punct	", ",detected
R6009	T20529	T20530	prep	of,was
R6010	T20530	T20520	ccomp	was,detected
R6011	T20531	T20529	pobj	which,of
R6012	T20532	T20533	det	the,species
R6013	T20533	T20530	nsubj	species,was
R6014	T20534	T20533	advmod	faster,species
R6015	T20535	T20533	amod	migrating,species
R6016	T20536	T20530	acomp	dominant,was
R6017	T20537	T20530	prep	in,was
R6018	T20538	T20537	amod	nuclear,in
R6019	T20539	T20530	cc	and,was
R6020	T20540	T20541	det	the,species
R6021	T20541	T20543	nsubj	species,was
R6022	T20542	T20541	amod	slower,species
R6023	T20543	T20530	conj	was,was
R6024	T20544	T20543	acomp	dominant,was
R6025	T20545	T20543	prep	in,was
R6026	T20546	T20545	pobj	cytoplasm,in
R6027	T20547	T20548	punct	(,Figure
R6028	T20548	T20543	parataxis	Figure,was
R6029	T20549	T20548	nummod	6,Figure
R6030	T20550	T20548	punct	),Figure
R6031	T20551	T20520	punct	.,detected
R6032	T20553	T20554	det	The,identity
R6033	T20554	T20555	nsubjpass	identity,confirmed
R6034	T20556	T20554	prep	of,identity
R6035	T20557	T20556	pobj	both,of
R6036	T20558	T20554	prep	as,identity
R6037	T20559	T20560	compound	E2f3a,species
R6038	T20560	T20558	pobj	species,as
R6039	T20561	T20555	auxpass	was,confirmed
R6040	T20562	T20555	agent	by,confirmed
R6041	T20563	T20564	poss	their,absence
R6042	T20564	T20562	pobj	absence,by
R6043	T20565	T20564	prep	in,absence
R6044	T20566	T20567	det	the,retina
R6045	T20567	T20565	pobj	retina,in
R6046	T20568	T20567	compound	P18,retina
R6047	T20569	T20570	compound	E2f3a,KO
R6048	T20570	T20567	compound	KO,retina
R6049	T20571	T20572	punct	(,S8
R6050	T20572	T20555	parataxis	S8,confirmed
R6051	T20573	T20572	compound	Figure,S8
R6052	T20574	T20572	punct	),S8
R6053	T20575	T20555	punct	.,confirmed
R6054	T20577	T20578	nsubj	Analysis,showed
R6055	T20579	T20577	prep	of,Analysis
R6056	T20580	T20579	pobj	Pou4f2,of
R6057	T20581	T20580	punct	", ",Pou4f2
R6058	T20582	T20583	det	a,factor
R6059	T20583	T20580	appos	factor,Pou4f2
R6060	T20584	T20583	amod	nuclear,factor
R6061	T20585	T20583	compound	transcription,factor
R6062	T20586	T20583	acl	expressed,factor
R6063	T20587	T20586	prep	in,expressed
R6064	T20588	T20589	compound	ganglion,cells
R6065	T20589	T20587	pobj	cells,in
R6066	T20590	T20578	punct	", ",showed
R6067	T20591	T20592	mark	that,contaminated
R6068	T20592	T20578	ccomp	contaminated,showed
R6069	T20593	T20594	amod	nuclear,proteins
R6070	T20594	T20592	nsubj	proteins,contaminated
R6071	T20595	T20592	aux	had,contaminated
R6072	T20596	T20592	neg	not,contaminated
R6073	T20597	T20598	det	the,fraction
R6074	T20598	T20592	dobj	fraction,contaminated
R6075	T20599	T20598	amod	cytoplasmic,fraction
R6076	T20600	T20578	punct	", ",showed
R6077	T20601	T20578	cc	and,showed
R6078	T20602	T20603	nsubj	analysis,confirmed
R6079	T20603	T20578	conj	confirmed,showed
R6080	T20604	T20602	prep	of,analysis
R6081	T20605	T20604	pobj	Slc18a3,of
R6082	T20606	T20605	punct	", ",Slc18a3
R6083	T20607	T20608	det	a,marker
R6084	T20608	T20605	appos	marker,Slc18a3
R6085	T20609	T20608	amod	cytoplasmic,marker
R6086	T20610	T20608	compound	SAC,marker
R6087	T20611	T20603	punct	", ",confirmed
R6088	T20612	T20613	mark	that,occurred
R6089	T20613	T20603	ccomp	occurred,confirmed
R6090	T20614	T20615	det	the,reverse
R6091	T20615	T20613	nsubj	reverse,occurred
R6092	T20616	T20613	aux	had,occurred
R6093	T20617	T20613	advmod	also,occurred
R6094	T20618	T20613	neg	not,occurred
R6095	T20619	T20620	punct	(,Figure
R6096	T20620	T20613	parataxis	Figure,occurred
R6097	T20621	T20620	nummod	6,Figure
R6098	T20622	T20620	punct	),Figure
R6099	T20623	T20603	punct	.,confirmed
R6100	T20625	T20626	det	These,data
R6101	T20626	T20627	nsubj	data,show
R6102	T20628	T20627	punct	", ",show
R6103	T20629	T20630	prep	to,for
R6104	T20630	T20627	prep	for,show
R6105	T20631	T20632	poss	our,knowledge
R6106	T20632	T20629	pobj	knowledge,to
R6107	T20633	T20634	det	the,time
R6108	T20634	T20630	pobj	time,for
R6109	T20635	T20634	amod	first,time
R6110	T20636	T20627	punct	", ",show
R6111	T20637	T20638	mark	that,exhibit
R6112	T20638	T20627	ccomp	exhibit,show
R6113	T20639	T20638	nsubj	E2f3a,exhibit
R6114	T20640	T20639	cc	and,E2f3a
R6115	T20641	T20639	conj	E2f3b,E2f3a
R6116	T20642	T20643	amod	distinct,patterns
R6117	T20643	T20638	dobj	patterns,exhibit
R6118	T20644	T20643	prep	of,patterns
R6119	T20645	T20646	amod	subcellular,distribution
R6120	T20646	T20644	pobj	distribution,of
R6121	T20647	T20638	punct	", ",exhibit
R6122	T20648	T20638	cc	and,exhibit
R6123	T20649	T20638	conj	raise,exhibit
R6124	T20650	T20651	det	the,possibility
R6125	T20651	T20649	dobj	possibility,raise
R6126	T20652	T20653	mark	that,regulated
R6127	T20653	T20651	acl	regulated,possibility
R6128	T20654	T20655	compound	E2f3a,localization
R6129	T20655	T20653	nsubjpass	localization,regulated
R6130	T20656	T20653	aux	may,regulated
R6131	T20657	T20653	auxpass	be,regulated
R6132	T20658	T20653	agent	by,regulated
R6133	T20659	T20660	advmod	as,yet
R6134	T20660	T20661	advmod	yet,unknown
R6135	T20661	T20662	amod	unknown,modifications
R6156	T20686	T20682	acomp	present,was
R6157	T20687	T20682	prep	in,was
R6158	T20688	T20689	preconj	both,cytoplasm
R6159	T20689	T20687	pobj	cytoplasm,in
R6160	T20690	T20689	det	the,cytoplasm
R6161	T20691	T20689	compound	WT,cytoplasm
R6162	T20692	T20689	cc	and,cytoplasm
R6163	T20693	T20689	conj	nucleus,cytoplasm
R6164	T20694	T20682	prep	at,was
R6165	T20695	T20694	pobj	P0,at
R6166	T20696	T20682	punct	", ",was
R6167	T20697	T20682	cc	but,was
R6168	T20698	T20699	prep	at,was
R6169	T20699	T20682	conj	was,was
R6170	T20700	T20698	pobj	P18,at
R6171	T20701	T20699	punct	", ",was
R6172	T20702	T20703	advmod	when,increased
R6173	T20703	T20699	advcl	increased,was
R6174	T20704	T20705	det	the,levels
R6175	T20705	T20703	nsubj	levels,increased
R6176	T20706	T20705	prep	of,levels
R6177	T20707	T20706	pobj	Rb,of
R6178	T20708	T20703	aux	had,increased
R6179	T20709	T20699	punct	", ",was
R6180	T20710	T20699	nsubj	it,was
R6181	T20711	T20699	advmod	primarily,was
R6182	T20712	T20699	acomp	nuclear,was
R6183	T20713	T20714	punct	(,Figure
R6184	T20714	T20699	parataxis	Figure,was
R6185	T20715	T20714	nummod	6,Figure
R6186	T20716	T20714	punct	),Figure
R6187	T20717	T20699	punct	.,was
R6188	T20719	T20720	det	A,signal
R6189	T20720	T20725	nsubj	signal,was
R6190	T20721	T20722	advmod	very,faint
R6191	T20722	T20720	amod	faint,signal
R6192	T20723	T20720	amod	cytoplasmic,signal
R6193	T20724	T20720	compound	Rb,signal
R6194	T20726	T20725	acomp	evident,was
R6195	T20727	T20725	prep	at,was
R6196	T20728	T20727	pobj	P18,at
R6197	T20729	T20725	punct	", ",was
R6198	T20730	T20731	dep	which,is
R6199	T20731	T20725	advcl	is,was
R6200	T20732	T20731	acomp	consistent,is
R6201	T20733	T20732	prep	with,consistent
R6202	T20734	T20735	compound	Rb,staining
R6203	T20735	T20733	pobj	staining,with
R6204	T20736	T20735	prep	of,staining
R6205	T20737	T20738	compound	SAC,processes
R6206	T20738	T20736	pobj	processes,of
R6207	T20739	T20740	punct	(,5B
R6208	T20740	T20735	parataxis	5B,staining
R6209	T20741	T20740	compound	Figure,5B
R6210	T20742	T20740	punct	),5B
R6211	T20743	T20733	punct	", ",with
R6212	T20744	T20733	cc	and,with
R6213	T20745	T20733	conj	with,with
R6214	T20746	T20747	det	the,proportion
R6215	T20747	T20745	pobj	proportion,with
R6216	T20748	T20749	advmod	very,small
R6217	T20749	T20747	amod	small,proportion
R6218	T20750	T20747	prep	of,proportion
R6219	T20751	T20750	pobj	SACs,of
R6220	T20752	T20747	prep	in,proportion
R6221	T20753	T20754	det	the,retina
R6222	T20754	T20752	pobj	retina,in
R6223	T20755	T20756	punct	[,38
R6224	T20756	T20731	parataxis	38,is
R6225	T20757	T20756	punct	],38
R6226	T20758	T20725	punct	.,was
R6227	T20760	T20761	nsubjpass	E2f1,detected
R6228	T20762	T20761	auxpass	was,detected
R6229	T20763	T20761	advmod	also,detected
R6230	T20764	T20761	prep	in,detected
R6231	T20765	T20766	preconj	both,nuclear
R6232	T20766	T20767	amod	nuclear,fractions
R6233	T20767	T20764	pobj	fractions,in
R6234	T20768	T20766	cc	and,nuclear
R6235	T20769	T20766	conj	cytoplasmic,nuclear
R6236	T20770	T20761	punct	", ",detected
R6237	T20771	T20772	mark	although,was
R6238	T20772	T20761	advcl	was,detected
R6239	T20773	T20772	prep	unlike,was
R6240	T20774	T20773	pobj	E2f3a,unlike
R6241	T20775	T20772	nsubj	it,was
R6242	T20776	T20777	advmod	predominantly,nuclear
R6243	T20777	T20772	acomp	nuclear,was
R6244	T20778	T20779	preconj	both,at
R6245	T20779	T20772	prep	at,was
R6246	T20780	T20779	pobj	P0,at
R6247	T20781	T20780	cc	and,P0
R6248	T20782	T20780	conj	P18,P0
R6249	T20783	T20784	punct	(,Figure
R6250	T20784	T20772	parataxis	Figure,was
R6251	T20785	T20784	nummod	6,Figure
R6252	T20786	T20784	punct	),Figure
R6253	T20787	T20761	punct	.,detected
R6254	T20789	T20790	det	The,partner
R6255	T20790	T20793	nsubj	partner,was
R6256	T20791	T20790	compound	E2f,partner
R6257	T20792	T20790	compound	dimerization,partner
R6258	T20794	T20790	punct	", ",partner
R6259	T20795	T20790	appos	Tfdp1,partner
R6260	T20796	T20790	punct	", ",partner
R6261	T20797	T20798	dep	which,lacks
R6262	T20798	T20790	relcl	lacks,partner
R6263	T20799	T20800	det	a,signal
R6264	T20800	T20798	dobj	signal,lacks
R6265	T20801	T20802	amod	nuclear,localization
R6266	T20802	T20800	compound	localization,signal
R6267	T20803	T20804	punct	[,54
R6268	T20804	T20798	parataxis	54,lacks
R6269	T20805	T20804	punct	],54
R6270	T20806	T20793	punct	", ",was
R6271	T20807	T20808	advmod	primarily,cytoplasmic
R6272	T20808	T20793	acomp	cytoplasmic,was
R6273	T20809	T20793	prep	at,was
R6274	T20810	T20811	preconj	both,P0
R6275	T20811	T20809	pobj	P0,at
R6276	T20812	T20811	cc	and,P0
R6277	T20813	T20811	conj	P18,P0
R6278	T20814	T20793	punct	", ",was
R6279	T20815	T20793	cc	and,was
R6280	T20816	T20817	det	the,inhibitors
R6281	T20817	T20819	nsubj	inhibitors,showed
R6282	T20818	T20817	compound	Cdk,inhibitors
R6283	T20819	T20793	conj	showed,was
R6284	T20820	T20817	appos	Cdkn1a,inhibitors
R6285	T20821	T20820	cc	and,Cdkn1a
R6286	T20822	T20820	conj	Cdkn1b,Cdkn1a
R6287	T20823	T20824	det	a,pattern
R6288	T20824	T20819	dobj	pattern,showed
R6289	T20825	T20824	amod	similar,pattern
R6290	T20826	T20824	prep	of,pattern
R6291	T20827	T20826	pobj	distribution,of
R6292	T20828	T20829	punct	(,Figure
R6293	T20829	T20819	parataxis	Figure,showed
R6294	T20830	T20829	nummod	6,Figure
R6295	T20831	T20829	punct	),Figure
R6296	T20832	T20819	punct	.,showed
R6297	T20834	T20835	advmod	Thus,showed
R6298	T20836	T20835	punct	", ",showed
R6299	T20837	T20835	prep	among,showed
R6300	T20838	T20839	det	the,regulators
R6301	T20839	T20837	pobj	regulators,among
R6302	T20840	T20841	compound	cell,cycle
R6303	T20841	T20839	compound	cycle,regulators
R6304	T20842	T20843	nsubj	we,examined
R6305	T20843	T20839	advcl	examined,regulators
R6306	T20844	T20835	punct	", ",showed
R6307	T20845	T20835	nsubj	most,showed
R6308	T20846	T20847	amod	bivalent,distribution
R6309	T20847	T20835	dobj	distribution,showed
R6310	T20848	T20835	punct	", ",showed
R6311	T20849	T20835	cc	and,showed
R6312	T20850	T20851	nsubj	E2f3b,was
R6313	T20851	T20835	conj	was,showed
R6314	T20852	T20851	acomp	unusual,was
R6315	T20853	T20851	prep	in,was
R6316	T20854	T20855	poss	its,compartmentalization
R6317	T20855	T20853	pobj	compartmentalization,in
R6318	T20856	T20857	advmod	solely,nuclear
R6319	T20857	T20855	amod	nuclear,compartmentalization
R6320	T20858	T20851	punct	.,was
R11271	T37145	T37146	amod	Subcellular,Distribution
R11272	T37147	T37146	prep	of,Distribution
R11273	T37148	T37149	compound	E2f3,Isoforms
R11274	T37149	T37147	pobj	Isoforms,of
R11275	T37150	T37149	cc	and,Isoforms
R11276	T37151	T37152	amod	Other,Proteins
R11277	T37152	T37149	conj	Proteins,Isoforms
R11278	T37153	T37154	compound	Cell,Cycle
R11279	T37154	T37152	compound	Cycle,Proteins
R11280	T37155	T37146	prep	in,Distribution
R11281	T37156	T37157	det	the,Retina
R11282	T37157	T37155	pobj	Retina,in
R11283	T37158	T37157	amod	Developing,Retina
R11284	T37160	T37161	amod	Nuclear,extracts
R11285	T37161	T37164	nsubjpass	extracts,analyzed
R11286	T37162	T37160	cc	and,Nuclear
R11287	T37163	T37160	conj	cytoplasmic,Nuclear
R11288	T37165	T37161	prep	from,extracts
R11289	T37166	T37167	det	an,number
R11290	T37167	T37165	pobj	number,from
R11291	T37168	T37167	amod	equivalent,number
R11292	T37169	T37167	prep	of,number
R11293	T37170	T37171	amod	retinal,cells
R11294	T37171	T37169	pobj	cells,of
R11295	T37172	T37171	prep	from,cells
R11296	T37173	T37172	pobj	mice,from
R11297	T37174	T37173	prep	of,mice
R11298	T37175	T37176	det	the,genotypes
R11299	T37176	T37174	pobj	genotypes,of
R11300	T37177	T37176	amod	indicated,genotypes
R11301	T37178	T37176	cc	and,genotypes
R11302	T37179	T37176	conj	ages,genotypes
R11303	T37180	T37164	auxpass	were,analyzed
R11304	T37181	T37164	prep	by,analyzed
R11305	T37182	T37183	compound	Western,blotting
R11306	T37183	T37181	pobj	blotting,by
R11307	T37184	T37185	aux	to,detect
R11308	T37185	T37164	advcl	detect,analyzed
R11309	T37186	T37187	det	the,proteins
R11310	T37187	T37185	dobj	proteins,detect
R11311	T37188	T37187	amod	indicated,proteins
R11312	T37189	T37164	punct	.,analyzed
R11313	T37191	T37192	nsubjpass	Lysate,used
R11314	T37193	T37191	prep	from,Lysate
R11315	T37194	T37195	nmod	E2f3a,mice
R11316	T37195	T37193	pobj	mice,from
R11317	T37196	T37194	punct	−,E2f3a
R11318	T37197	T37194	punct	/,E2f3a
R11319	T37198	T37194	punct	−,E2f3a
R11320	T37199	T37192	auxpass	was,used
R11321	T37200	T37192	prep	as,used
R11322	T37201	T37202	det	a,control
R11323	T37202	T37200	pobj	control,as
R11324	T37203	T37204	aux	to,confirm
R11325	T37204	T37192	advcl	confirm,used
R11326	T37205	T37206	det	the,location
R11327	T37206	T37204	dobj	location,confirm
R11328	T37207	T37206	prep	of,location
R11329	T37208	T37209	compound	E2f3a,protein
R11330	T37209	T37207	pobj	protein,of
R11331	T37210	T37192	punct	.,used
R11332	T37213	T37212	punct	", ",C
R11333	T37214	T37215	amod	cytoplasmic,extracts
R11334	T37215	T37212	appos	extracts,C
R11335	T37216	T37212	punct	;,C
R11336	T37217	T37212	appos	N,C
R11337	T37218	T37217	punct	", ",N
R11338	T37219	T37220	amod	nuclear,extracts
R11339	T37220	T37217	appos	extracts,N
R11340	T37221	T37212	punct	.,C
R11341	T37915	T37916	det	The,Isoform
R11342	T37916	T37918	nsubj	Isoform,Drives
R11343	T37917	T37916	compound	E2f3a,Isoform
R11344	T37919	T37920	det	the,Defect
R11345	T37920	T37918	dobj	Defect,Drives
R11346	T37921	T37920	compound	Differentiation,Defect
R11347	T37922	T37918	prep	in,Drives
R11348	T37923	T37924	compound	Rb,KO
R11349	T37924	T37925	compound	KO,SACs
R11350	T37925	T37922	pobj	SACs,in
R11351	T37927	T37928	punct	(,A
R11352	T37928	T37929	meta	A,diagrams
R11353	T37930	T37928	punct	),A
R11354	T37931	T37929	amod	Schematic,diagrams
R11355	T37932	T37929	prep	of,diagrams
R11356	T37933	T37934	det	the,WT
R11357	T37934	T37932	pobj	WT,of
R11358	T37935	T37934	compound	mouse,WT
R11359	T37936	T37934	punct	", ",WT
R11360	T37937	T37934	conj	E2f3a,WT
R11361	T37938	T37937	punct	−,E2f3a
R11362	T37939	T37937	punct	/,E2f3a
R11363	T37940	T37937	punct	−,E2f3a
R11364	T37941	T37937	punct	", ",E2f3a
R11365	T37942	T37937	cc	and,E2f3a
R11366	T37943	T37944	det	the,loci
R11367	T37944	T37937	conj	loci,E2f3a
R11368	T37945	T37944	nmod	Cre,loci
R11369	T37946	T37945	punct	-,Cre
R11370	T37947	T37945	amod	recombined,Cre
R11371	T37948	T37944	amod	floxed,loci
R11372	T37949	T37944	compound	E2f3,loci
R11373	T37950	T37944	punct	(,loci
R11374	T37951	T37944	acl	indicated,loci
R11375	T37952	T37951	advmod	here,indicated
R11376	T37953	T37951	prep	as,indicated
R11377	T37954	T37953	pobj	E2f3,as
R11378	T37955	T37954	punct	−,E2f3
R11379	T37956	T37954	punct	/,E2f3
R11380	T37957	T37954	punct	−,E2f3
R11381	T37958	T37951	prep	for,indicated
R11382	T37959	T37958	pobj	simplicity,for
R11383	T37960	T37929	punct	),diagrams
R11384	T37961	T37929	punct	.,diagrams
R11385	T37963	T37964	nmod	E2f3a,mice
R11386	T37964	T37968	nsubj	mice,lack
R11387	T37965	T37963	punct	−,E2f3a
R11388	T37966	T37963	punct	/,E2f3a
R11389	T37967	T37963	punct	−,E2f3a
R11390	T37969	T37968	dobj	most,lack
R11391	T37970	T37969	prep	of,most
R11392	T37971	T37972	compound	E2f3,1a
R11393	T37972	T37970	pobj	1a,of
R11394	T37973	T37972	compound	exon,1a
R11395	T37974	T37969	cc	and,most
R11396	T37975	T37969	conj	part,most
R11397	T37976	T37975	prep	of,part
R11398	T37977	T37978	compound	intron,1a
R11399	T37978	T37976	pobj	1a,of
R11400	T37979	T37980	punct	(,box
R11401	T37980	T37968	parataxis	box,lack
R11402	T37981	T37980	amod	red,box
R11403	T37982	T37980	amod	dotted,box
R11404	T37983	T37980	punct	),box
R11405	T37984	T37968	punct	.,lack
R11406	T37986	T37987	nsubj	Arrows,indicate
R11407	T37988	T37989	compound	PCR,primers
R11408	T37989	T37987	dobj	primers,indicate
R11409	T37990	T37987	punct	.,indicate
R11410	T37992	T37993	nsubjpass	Genotyping,shown
R11411	T37994	T37992	prep	of,Genotyping
R11412	T37995	T37996	det	an,mouse
R11413	T37996	T37994	pobj	mouse,of
R11414	T37997	T37996	nmod	E2f3a,mouse
R11415	T37998	T37997	punct	+,E2f3a
R11416	T37999	T37997	punct	/,E2f3a
R11417	T38000	T37997	punct	−,E2f3a
R11418	T38001	T37993	auxpass	is,shown
R11419	T38002	T37993	prep	on,shown
R11420	T38003	T38004	det	the,right
R11421	T38004	T38002	pobj	right,on
R11422	T38005	T37993	punct	.,shown
R11423	T38007	T38008	punct	(,B
R11424	T38008	T38009	meta	B,detection
R11425	T38010	T38008	punct	),B
R11426	T38011	T38012	compound	RT,PCR
R11427	T38012	T38009	compound	PCR,detection
R11428	T38013	T38012	punct	-,PCR
R11429	T38014	T38009	prep	of,detection
R11430	T38015	T38016	nmod	E2f3a,mRNA
R11431	T38016	T38014	pobj	mRNA,of
R11432	T38017	T38015	cc	and,E2f3a
R11433	T38018	T38015	conj	E2f3b,E2f3a
R11434	T38019	T38009	prep	in,detection
R11435	T38020	T38021	det	the,retina
R11436	T38021	T38019	pobj	retina,in
R11437	T38022	T38009	punct	.,detection
R11438	T38024	T38025	det	The,sequences
R11439	T38025	T38026	nsubj	sequences,are
R11440	T38027	T38025	prep	of,sequences
R11441	T38028	T38027	pobj	primers,of
R11442	T38029	T38026	attr	1aF,are
R11443	T38030	T38029	punct	(,1aF
R11444	T38031	T38032	nummod	5,GCCTCTACACCACGCCACAAG
R11445	T38032	T38029	appos	GCCTCTACACCACGCCACAAG,1aF
R11446	T38033	T38031	punct	′,5
R11447	T38034	T38032	punct	-,GCCTCTACACCACGCCACAAG
R11448	T38035	T38032	punct	-,GCCTCTACACCACGCCACAAG
R11449	T38036	T38032	nummod	3,GCCTCTACACCACGCCACAAG
R11450	T38037	T38032	punct	′,GCCTCTACACCACGCCACAAG
R11451	T38038	T38029	punct	),1aF
R11452	T38039	T38029	punct	", ",1aF
R11453	T38040	T38029	conj	1bF,1aF
R11454	T38041	T38040	punct	(,1bF
R11455	T38042	T38043	nummod	5,CGGAAATGCCCTTACAGC
R11456	T38043	T38040	appos	CGGAAATGCCCTTACAGC,1bF
R11457	T38044	T38042	punct	′,5
R11458	T38045	T38043	punct	-,CGGAAATGCCCTTACAGC
R11459	T38046	T38043	punct	-,CGGAAATGCCCTTACAGC
R11460	T38047	T38043	nummod	3,CGGAAATGCCCTTACAGC
R11461	T38048	T38043	punct	′,CGGAAATGCCCTTACAGC
R11462	T38049	T38040	punct	),1bF
R11463	T38050	T38040	punct	", ",1bF
R11464	T38051	T38040	cc	and,1bF
R11465	T38052	T38040	conj	4R,1bF
R11466	T38053	T38052	punct	(,4R
R11467	T38054	T38055	nummod	5,CTCAGTCACTTCTTTGGACAG
R11468	T38055	T38052	appos	CTCAGTCACTTCTTTGGACAG,4R
R11469	T38056	T38054	punct	′,5
R11470	T38057	T38055	punct	-,CTCAGTCACTTCTTTGGACAG
R11471	T38058	T38055	punct	-,CTCAGTCACTTCTTTGGACAG
R11472	T38059	T38055	nummod	3,CTCAGTCACTTCTTTGGACAG
R11473	T38060	T38055	punct	′,CTCAGTCACTTCTTTGGACAG
R11474	T38061	T38026	punct	),are
R11475	T38062	T38026	punct	.,are
R11476	T38064	T38065	compound	WT,retina
R11477	T38065	T38066	nsubj	retina,expresses
R11478	T38067	T38068	preconj	both,E2f3a
R11479	T38068	T38069	nmod	E2f3a,mRNA
R11480	T38069	T38066	dobj	mRNA,expresses
R11481	T38070	T38068	cc	and,E2f3a
R11482	T38071	T38068	conj	E2f3b,E2f3a
R11483	T38072	T38066	punct	.,expresses
R11484	T38074	T38075	mark	As,expected
R11485	T38075	T38076	advcl	expected,lacks
R11486	T38077	T38076	punct	", ",lacks
R11487	T38078	T38079	nmod	E2f3a,retina
R11488	T38079	T38076	nsubj	retina,lacks
R11489	T38080	T38078	punct	−,E2f3a
R11490	T38081	T38078	punct	/,E2f3a
R11491	T38082	T38078	punct	−,E2f3a
R11492	T38083	T38084	compound	E2f3a,mRNA
R11493	T38084	T38076	dobj	mRNA,lacks
R11494	T38085	T38076	cc	and,lacks
R11495	T38086	T38087	advmod	still,expresses
R11496	T38087	T38076	conj	expresses,lacks
R11497	T38088	T38089	compound	E2f3b,mRNA
R11498	T38089	T38087	dobj	mRNA,expresses
R11499	T38090	T38076	punct	.,lacks
R11500	T38092	T38093	nmod	E2f3,retina
R11501	T38093	T38097	nsubj	retina,lacks
R11502	T38094	T38092	punct	−,E2f3
R11503	T38095	T38092	punct	/,E2f3
R11504	T38096	T38092	punct	−,E2f3
R11505	T38098	T38099	amod	full,length
R11506	T38099	T38101	nmod	length,mRNAs
R11507	T38100	T38099	punct	-,length
R11508	T38101	T38097	dobj	mRNAs,lacks
R11509	T38102	T38101	nmod	E2f3a,mRNAs
R11510	T38103	T38102	cc	and,E2f3a
R11511	T38104	T38102	conj	E2f3b,E2f3a
R11512	T38105	T38097	punct	", ",lacks
R11513	T38106	T38097	cc	and,lacks
R11514	T38107	T38108	advmod	instead,expresses
R11515	T38108	T38097	conj	expresses,lacks
R11516	T38109	T38110	det	a,mRNA
R11517	T38110	T38108	dobj	mRNA,expresses
R11518	T38111	T38110	amod	truncated,mRNA
R11519	T38112	T38110	acl	lacking,mRNA
R11520	T38113	T38112	dobj	exon,lacking
R11521	T38114	T38113	nummod	3,exon
R11522	T38115	T38097	punct	.,lacks
R11523	T38117	T38118	punct	(,C
R11524	T38118	T38119	meta	C,analysis
R11525	T38120	T38118	punct	),C
R11526	T38121	T38122	amod	Real,time
R11527	T38122	T38119	compound	time,analysis
R11528	T38123	T38122	punct	-,time
R11529	T38124	T38125	compound	RT,PCR
R11530	T38125	T38119	compound	PCR,analysis
R11531	T38126	T38125	punct	-,PCR
R11532	T38127	T38119	prep	of,analysis
R11533	T38128	T38129	compound	E2f,genes
R11534	T38129	T38127	pobj	genes,of
R11535	T38130	T38119	prep	in,analysis
R11536	T38131	T38132	compound	P8,retinas
R11537	T38132	T38130	pobj	retinas,in
R11538	T38133	T38132	prep	of,retinas
R11539	T38134	T38135	det	the,genotypes
R11540	T38135	T38133	pobj	genotypes,of
R11541	T38136	T38135	amod	indicated,genotypes
R11542	T38137	T38119	punct	.,analysis
R11543	T38139	T38140	compound	Error,bars
R11544	T38140	T38141	nsubj	bars,represent
R11545	T38142	T38141	dobj	SD,represent
R11546	T38143	T38142	prep	of,SD
R11547	T38144	T38143	pobj	measurements,of
R11548	T38145	T38144	prep	from,measurements
R11549	T38146	T38147	nummod	three,animals
R11550	T38147	T38145	pobj	animals,from
R11551	T38148	T38141	punct	", ",represent
R11552	T38149	T38141	cc	and,represent
R11553	T38150	T38151	nsubj	asterisks,indicate
R11554	T38151	T38141	conj	indicate,represent
R11555	T38152	T38153	det	a,difference
R11556	T38153	T38151	dobj	difference,indicate
R11557	T38154	T38153	amod	significant,difference
R11558	T38155	T38153	prep	between,difference
R11559	T38156	T38155	pobj	WT,between
R11560	T38157	T38156	cc	and,WT
R11561	T38158	T38159	det	the,indicated
R11562	T38159	T38160	nmod	indicated,genotypes
R11563	T38160	T38156	conj	genotypes,WT
R11564	T38161	T38162	punct	(,test
R11565	T38162	T38153	parataxis	test,difference
R11566	T38163	T38164	punct	*,0.05
R11567	T38164	T38162	ccomp	0.05,test
R11568	T38165	T38164	punct	", ",0.05
R11569	T38166	T38164	nsubj	p,0.05
R11570	T38167	T38164	punct	<,0.05
R11571	T38168	T38162	punct	;,test
R11572	T38169	T38170	punct	**,0.01
R11573	T38170	T38162	ccomp	0.01,test
R11574	T38171	T38170	punct	;,0.01
R11575	T38172	T38170	nsubj	p,0.01
R11576	T38173	T38170	punct	<,0.01
R11577	T38174	T38162	punct	;,test
R11578	T38175	T38162	nmod	ANOVA,test
R11579	T38176	T38175	cc	and,ANOVA
R11580	T38177	T38178	compound	Tukey,HSD
R11581	T38178	T38175	conj	HSD,ANOVA
R11582	T38179	T38162	punct	),test
R11583	T38180	T38151	punct	.,indicate
R11584	T38182	T38183	punct	(,D
R11585	T38183	T38184	meta	D,Rescue
R11586	T38185	T38183	punct	),D
R11587	T38186	T38184	prep	of,Rescue
R11588	T38187	T38188	compound	Rb,KO
R11589	T38188	T38189	compound	KO,SACs
R11590	T38189	T38186	pobj	SACs,of
R11591	T38190	T38184	prep	by,Rescue
R11592	T38191	T38192	compound	E2f3a,deletion
R11593	T38192	T38190	pobj	deletion,by
R11594	T38193	T38184	punct	.,Rescue
R11595	T38195	T38196	amod	Horizontal,sections
R11596	T38196	T38198	nsubjpass	sections,stained
R11597	T38197	T38196	amod	retinal,sections
R11598	T38199	T38196	prep	of,sections
R11599	T38200	T38201	det	the,genotypes
R11600	T38201	T38199	pobj	genotypes,of
R11601	T38202	T38201	amod	indicated,genotypes
R11602	T38203	T38201	cc	and,genotypes
R11603	T38204	T38201	conj	ages,genotypes
R11604	T38205	T38198	auxpass	were,stained
R11605	T38206	T38198	prep	for,stained
R11606	T38207	T38206	pobj	nuclei,for
R11607	T38208	T38209	punct	(,blue
R11608	T38209	T38207	parataxis	blue,nuclei
R11609	T38210	T38209	dep	DAPI,blue
R11610	T38211	T38209	punct	", ",blue
R11611	T38212	T38209	punct	),blue
R11612	T38213	T38207	punct	", ",nuclei
R11613	T38214	T38215	compound	M,phase
R11614	T38215	T38207	conj	phase,nuclei
R11615	T38216	T38215	punct	-,phase
R11616	T38217	T38218	punct	(,green
R11617	T38218	T38215	parataxis	green,phase
R11618	T38219	T38218	dep	PH3,green
R11619	T38220	T38218	punct	", ",green
R11620	T38221	T38218	punct	),green
R11621	T38222	T38215	punct	", ",phase
R11622	T38223	T38215	cc	and,phase
R11623	T38224	T38225	det	the,marker
R11624	T38225	T38215	conj	marker,phase
R11625	T38226	T38225	compound	SAC,marker
R11626	T38227	T38225	appos	Slc18a3,marker
R11627	T38228	T38229	punct	(,red
R11628	T38229	T38225	parataxis	red,marker
R11629	T38230	T38229	punct	),red
R11630	T38231	T38198	punct	.,stained
R11631	T38233	T38234	compound	E2f3a,deletion
R11632	T38234	T38235	nsubj	deletion,suppress
R11633	T38236	T38235	aux	does,suppress
R11634	T38237	T38235	neg	not,suppress
R11635	T38238	T38239	amod	ectopic,division
R11636	T38239	T38235	dobj	division,suppress
R11637	T38240	T38235	punct	", ",suppress
R11638	T38241	T38235	cc	but,suppress
R11639	T38242	T38235	conj	rescues,suppress
R11640	T38243	T38244	det	the,defect
R11641	T38244	T38242	dobj	defect,rescues
R11642	T38245	T38244	compound	SAC,defect
R11643	T38246	T38235	punct	.,suppress
R11644	T38248	T38249	compound	Scale,bars
R11645	T38249	T38250	nsubj	bars,are
R11646	T38251	T38252	nummod	50,μm
R11647	T38252	T38250	attr	μm,are
R11648	T38253	T38250	punct	.,are
R11649	T38256	T38255	punct	", ",M
R11650	T38257	T38258	amod	molecular,size
R11651	T38258	T38259	compound	size,marker
R11652	T38259	T38255	appos	marker,M
R11653	T38260	T38255	punct	.,M
R6136	T20662	T20658	pobj	modifications,by
R6137	T20663	T20662	amod	post-translational,modifications
R6138	T20664	T20627	punct	.,show
R6139	T20666	T20667	nsubj	We,examined
R6140	T20668	T20667	advmod	also,examined
R6141	T20669	T20670	det	the,distribution
R6142	T20670	T20667	dobj	distribution,examined
R6143	T20671	T20670	prep	of,distribution
R6144	T20672	T20673	amod	other,regulators
R6145	T20673	T20671	pobj	regulators,of
R6146	T20674	T20675	compound	cell,cycle
R6147	T20675	T20673	compound	cycle,regulators
R6148	T20676	T20667	prep	during,examined
R6149	T20677	T20678	amod	retinal,development
R6150	T20678	T20676	pobj	development,during
R6151	T20679	T20667	punct	.,examined
R6152	T20681	T20682	prep	Like,was
R6153	T20683	T20681	pobj	E2f3a,Like
R6154	T20684	T20682	punct	", ",was
R6155	T20685	T20682	nsubj	Rb,was

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T20106	9-21	GO_PATO_EXT:biological_localization_process_or_quality	denotes	Localization
T20107	25-29	PR_EXT:000006854	denotes	E2f3
T20108	30-38	SO_EXT:0001060	denotes	Isoforms
T20109	55-59	PR_EXT:000006854	denotes	E2f3
T20110	64-66	PR_EXT:000013773	denotes	Rb
T20111	93-100	GO:0005634	denotes	nuclear
T20112	105-116	GO:0005737	denotes	cytoplasmic
T20113	141-149	GO:0042571	denotes	antibody
T20114	193-203	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T20115	246-254	SO_EXT:0001060	denotes	isoforms
T20116	278-289	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T20117	281-289	CL_GO_EXT:cell	denotes	cellular
T20118	302-306	PR_EXT:000006854	denotes	E2f3
T20119	307-315	SO_EXT:0001060	denotes	isoforms
T20120	347-351	CL_GO_EXT:cell	denotes	cell
T20121	390-394	PR_EXT:000006854	denotes	E2f3
T20122	418-426	SO_EXT:0001060	denotes	isoforms
T20123	443-449	UBERON:0000966	denotes	retina
T20124	463-470	GO:0005634	denotes	nuclear
T20125	475-486	GO:0005737	denotes	cytoplasmic
T20126	574-578	PR_EXT:000006854	denotes	E2f3
T20127	579-587	GO:0042571	denotes	antibody
T20128	640-645	PR_EXT:000028775	denotes	E2f3a
T20129	672-683	CHEBI_SO_EXT:polypeptide	denotes	polypeptide
T20130	737-744	UBERON:0000966	denotes	retinal
T20131	757-762	PR_EXT:000028775	denotes	E2f3a
T20132	783-787	NCBITaxon:10088	denotes	mice
T20133	798-802	PR_EXT:000006854	denotes	E2f3
T20134	803-807	SO_EXT:0000147	denotes	exon
T20135	820-827	GO:0010467	denotes	express
T20136	1027-1032	PR_EXT:000028775	denotes	E2f3a
T20137	1032-1033	SO_EXT:sequence_nullness_or_absence	denotes	−
T20138	1034-1035	SO_EXT:sequence_nullness_or_absence	denotes	−
T20139	1036-1040	NCBITaxon:10088	denotes	mice
T20140	1089-1093	PR_EXT:000006854	denotes	E2f3
T20202	4701-4704	PR_EXT:E2F	denotes	E2f
T20203	4705-4717	GO:0046983	denotes	dimerization
T20204	4727-4732	PR_EXT:000016269	denotes	Tfdp1
T20205	4748-4755	GO:0005634	denotes	nuclear
T20206	4748-4775	SO_EXT:0001528	denotes	nuclear localization signal
T20207	4756-4768	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T20208	4796-4807	GO:0005737	denotes	cytoplasmic
T20209	4836-4850	CHEBI_GO_EXT:cyclin_dependent_kinase_inhibitor	denotes	Cdk inhibitors
T20210	4851-4857	PR_EXT:000005274	denotes	Cdkn1a
T20211	4862-4868	PR_EXT:000003090	denotes	Cdkn1b
T20212	4938-4942	CL_GO_EXT:cell	denotes	cell
T20213	4938-4948	GO:0007049	denotes	cell cycle
T20214	4949-4959	GO_EXT:regulator	denotes	regulators
T20215	5044-5051	GO:0005634	denotes	nuclear
T37119	2273-2284	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	Subcellular
T37120	2276-2284	CL_GO_EXT:cell	denotes	cellular
T37121	2301-2305	PR_EXT:000006854	denotes	E2f3
T37122	2306-2314	SO_EXT:0001060	denotes	Isoforms
T37123	2325-2329	CL_GO_EXT:cell	denotes	Cell
T37124	2325-2335	GO:0007049	denotes	Cell Cycle
T37125	2336-2344	CHEBI_PR_EXT:protein	denotes	Proteins
T37126	2363-2369	UBERON:0000966	denotes	Retina
T37127	2370-2377	GO:0005634	denotes	Nuclear
T37128	2382-2393	GO:0005737	denotes	cytoplasmic
T37129	2432-2439	UBERON:0000966	denotes	retinal
T37130	2432-2445	CL:0009004	denotes	retinal cells
T37131	2440-2445	CL_GO_EXT:cell	denotes	cells
T37132	2451-2455	NCBITaxon:10088	denotes	mice
T37133	2473-2482	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T37134	2550-2558	CHEBI_PR_EXT:protein	denotes	proteins
T37135	2572-2577	PR_EXT:000028775	denotes	E2f3a
T37136	2577-2578	SO_EXT:sequence_nullness_or_absence	denotes	−
T37137	2579-2580	SO_EXT:sequence_nullness_or_absence	denotes	−
T37138	2581-2585	NCBITaxon:10088	denotes	mice
T37139	2635-2640	PR_EXT:000028775	denotes	E2f3a
T37140	2641-2648	CHEBI_PR_EXT:protein	denotes	protein
T37141	2650-2651	GO:0005737	denotes	C
T37142	2653-2664	GO:0005737	denotes	cytoplasmic
T37143	2675-2676	GO:0005634	denotes	N
T37144	2678-2685	GO:0005634	denotes	nuclear
T37834	2710-2715	PR_EXT:000028775	denotes	E2f3a
T37835	2716-2723	SO_EXT:0001060	denotes	Isoform
T37836	2735-2750	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T37837	2761-2763	PR_EXT:000013773	denotes	Rb
T37838	2802-2807	NCBITaxon:10088	denotes	mouse
T37839	2808-2810	SO_EXT:wild_type_entity_or_quality	denotes	WT
T37840	2812-2817	PR_EXT:000028775	denotes	E2f3a
T37841	2817-2818	SO_EXT:sequence_nullness_or_absence	denotes	−
T37842	2819-2820	SO_EXT:sequence_nullness_or_absence	denotes	−
T37843	2834-2844	GO_SO_EXT:sequence_rearrangement_process	denotes	recombined
T37844	2845-2851	SO:0000359	denotes	floxed
T37845	2852-2856	PR_EXT:000006854	denotes	E2f3
T37846	2881-2885	PR_EXT:000006854	denotes	E2f3
T37847	2885-2886	SO_EXT:sequence_nullness_or_absence	denotes	−
T37848	2887-2888	SO_EXT:sequence_nullness_or_absence	denotes	−
T37849	2906-2911	PR_EXT:000028775	denotes	E2f3a
T37850	2911-2912	SO_EXT:sequence_nullness_or_absence	denotes	−
T37851	2913-2914	SO_EXT:sequence_nullness_or_absence	denotes	−
T37852	2915-2919	NCBITaxon:10088	denotes	mice
T37853	2933-2937	PR_EXT:000006854	denotes	E2f3
T37854	2938-2942	SO_EXT:0000147	denotes	exon
T37855	2958-2964	SO_EXT:0000188	denotes	intron
T37856	3006-3013	SO_EXT:0000112	denotes	primers
T37857	3032-3037	PR_EXT:000028775	denotes	E2f3a
T37858	3037-3038	SO_EXT:normal_or_wild_type_or_present	denotes	+
T37859	3039-3040	SO_EXT:sequence_nullness_or_absence	denotes	−
T37860	3041-3046	NCBITaxon:10088	denotes	mouse
T37861	3074-3076	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T37862	3094-3099	PR_EXT:000028775	denotes	E2f3a
T37863	3110-3114	CHEBI_SO_EXT:mRNA	denotes	mRNA
T37864	3122-3128	UBERON:0000966	denotes	retina
T37865	3134-3143	SO_EXT:biological_sequence	denotes	sequences
T37866	3147-3154	SO_EXT:0000112	denotes	primers
T37867	3264-3266	SO_EXT:wild_type_entity_or_quality	denotes	WT
T37868	3267-3273	UBERON:0000966	denotes	retina
T37869	3274-3283	GO:0010467	denotes	expresses
T37870	3289-3294	PR_EXT:000028775	denotes	E2f3a
T37871	3305-3309	CHEBI_SO_EXT:mRNA	denotes	mRNA
T37872	3324-3329	PR_EXT:000028775	denotes	E2f3a
T37873	3329-3330	SO_EXT:sequence_nullness_or_absence	denotes	−
T37874	3331-3332	SO_EXT:sequence_nullness_or_absence	denotes	−
T37875	3333-3339	UBERON:0000966	denotes	retina
T37876	3346-3351	PR_EXT:000028775	denotes	E2f3a
T37877	3352-3356	CHEBI_SO_EXT:mRNA	denotes	mRNA
T37878	3367-3376	GO:0010467	denotes	expresses
T37879	3383-3387	CHEBI_SO_EXT:mRNA	denotes	mRNA
T37880	3389-3393	PR_EXT:000006854	denotes	E2f3
T37881	3393-3394	SO_EXT:sequence_nullness_or_absence	denotes	−
T37882	3395-3396	SO_EXT:sequence_nullness_or_absence	denotes	−
T37883	3397-3403	UBERON:0000966	denotes	retina
T37884	3422-3427	PR_EXT:000028775	denotes	E2f3a
T37885	3438-3443	CHEBI_SO_EXT:mRNA	denotes	mRNAs
T37886	3457-3466	GO:0010467	denotes	expresses
T37887	3469-3478	SO_EXT:sequence_truncation_process	denotes	truncated
T37888	3479-3483	CHEBI_SO_EXT:mRNA	denotes	mRNA
T37889	3492-3496	SO_EXT:0000147	denotes	exon
T37890	3514-3516	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T37891	3533-3536	PR_EXT:E2F	denotes	E2f
T37892	3537-3542	SO_EXT:0000704	denotes	genes
T37893	3549-3556	UBERON:0000966	denotes	retinas
T37894	3574-3583	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T37895	3636-3643	NCBITaxon:33208	denotes	animals
T37896	3701-3703	SO_EXT:wild_type_entity_or_quality	denotes	WT
T37897	3722-3731	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T37898	3789-3795	SO_EXT:sequence_rescue_process	denotes	Rescue
T37899	3799-3801	PR_EXT:000013773	denotes	Rb
T37900	3813-3818	PR_EXT:000028775	denotes	E2f3a
T37901	3819-3827	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T37902	3840-3847	UBERON:0000966	denotes	retinal
T37903	3874-3883	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T37904	3910-3916	GO:0005634	denotes	nuclei
T37905	3918-3922	CHEBI:51231	denotes	DAPI
T37906	3931-3938	GO:0000279	denotes	M-phase
T37907	3965-3971	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T37908	3972-3979	PR_EXT:000014968	denotes	Slc18a3
T37909	3987-3992	PR_EXT:000028775	denotes	E2f3a
T37910	3993-4001	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T37911	4042-4049	SO_EXT:sequence_rescue_process	denotes	rescues
T37912	4088-4089	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	M
T37913	4091-4100	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T37914	4106-4112	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T20150	1402-1409	GO:0005634	denotes	nuclear
T20141	1094-1104	GO:0010467	denotes	expressing
T20142	1105-1110	CL_GO_EXT:cell	denotes	cells
T20143	1118-1120	SO_EXT:wild_type_entity_or_quality	denotes	WT
T20144	1121-1128	UBERON:0000966	denotes	retinal
T20145	1129-1139	GO_PATO_EXT:biological_maturation	denotes	maturation
T20146	1173-1178	PR_EXT:000028775	denotes	E2f3a
T20147	1295-1300	PR_EXT:000028775	denotes	E2f3a
T20148	1321-1328	GO:0005634	denotes	nuclear
T20149	1333-1344	GO:0005737	denotes	cytoplasmic
T20151	1448-1457	GO_EXT:biological_movement_or_translocation_process	denotes	migrating
T20152	1458-1463	PR_EXT:000028775	denotes	E2f3a
T20153	1534-1543	GO_EXT:biological_movement_or_translocation_process	denotes	migrating
T20154	1568-1575	GO:0005634	denotes	nuclear
T20155	1615-1624	GO:0005737	denotes	cytoplasm
T20156	1661-1666	PR_EXT:000028775	denotes	E2f3a
T20157	1717-1722	PR_EXT:000028775	denotes	E2f3a
T20158	1726-1732	UBERON:0000966	denotes	retina
T20159	1758-1764	PR_EXT:000013042	denotes	Pou4f2
T20160	1768-1775	GO:0005634	denotes	nuclear
T20161	1776-1789	GO_EXT:transcription	denotes	transcription
T20162	1776-1796	GO_EXT:transcription_factor	denotes	transcription factor
T20163	1797-1806	GO:0010467	denotes	expressed
T20164	1810-1818	UBERON:0000045	denotes	ganglion
T20165	1810-1824	CL:0000740	denotes	ganglion cells
T20166	1819-1824	CL_GO_EXT:cell	denotes	cells
T20167	1838-1845	GO:0005634	denotes	nuclear
T20168	1846-1854	CHEBI_PR_EXT:protein	denotes	proteins
T20169	1880-1891	GO:0005737	denotes	cytoplasmic
T20170	1918-1925	PR_EXT:000014968	denotes	Slc18a3
T20171	1929-1940	GO:0005737	denotes	cytoplasmic
T20172	1945-1951	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T20173	2073-2078	PR_EXT:000028775	denotes	E2f3a
T20174	2118-2129	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T20175	2121-2129	CL_GO_EXT:cell	denotes	cellular
T20176	2175-2180	PR_EXT:000028775	denotes	E2f3a
T20177	2181-2193	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T20178	2201-2210	GO:0065007	denotes	regulated
T20179	2229-2261	GO_SO_EXT:post_translational_modification_entity_or_process	denotes	post-translational modifications
T20180	4157-4161	CL_GO_EXT:cell	denotes	cell
T20181	4157-4167	GO:0007049	denotes	cell cycle
T20182	4168-4178	GO_EXT:regulator	denotes	regulators
T20183	4186-4193	UBERON:0000966	denotes	retinal
T20184	4186-4205	GO:0060041	denotes	retinal development
T20185	4212-4217	PR_EXT:000028775	denotes	E2f3a
T20186	4219-4221	PR_EXT:000013773	denotes	Rb
T20187	4246-4248	SO_EXT:wild_type_entity_or_quality	denotes	WT
T20188	4249-4258	GO:0005737	denotes	cytoplasm
T20189	4263-4270	GO:0005634	denotes	nucleus
T20190	4309-4311	PR_EXT:000013773	denotes	Rb
T20191	4344-4351	GO:0005634	denotes	nuclear
T20192	4377-4388	GO:0005737	denotes	cytoplasmic
T20193	4389-4391	PR_EXT:000013773	denotes	Rb
T20194	4444-4446	PR_EXT:000013773	denotes	Rb
T20195	4463-4472	GO:0042995	denotes	processes
T20196	4536-4542	UBERON:0000966	denotes	retina
T20197	4549-4553	PR_EXT:000006852	denotes	E2f1
T20198	4580-4587	GO:0005634	denotes	nuclear
T20199	4592-4603	GO:0005737	denotes	cytoplasmic
T20200	4631-4636	PR_EXT:000028775	denotes	E2f3a
T20201	4658-4665	GO:0005634	denotes	nuclear

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T20025	25-29	PR:000006854	denotes	E2f3
T20026	30-38	SO:0001060	denotes	Isoforms
T20027	55-59	PR:000006854	denotes	E2f3
T20028	64-66	PR:000013773	denotes	Rb
T20029	93-100	GO:0005634	denotes	nuclear
T20030	105-116	GO:0005737	denotes	cytoplasmic
T20031	141-149	GO:0042571	denotes	antibody
T20032	246-254	SO:0001060	denotes	isoforms
T20033	302-306	PR:000006854	denotes	E2f3
T20034	307-315	SO:0001060	denotes	isoforms
T20035	390-394	PR:000006854	denotes	E2f3
T20036	418-426	SO:0001060	denotes	isoforms
T20037	443-449	UBERON:0000966	denotes	retina
T20038	463-470	GO:0005634	denotes	nuclear
T20039	475-486	GO:0005737	denotes	cytoplasmic
T20040	574-578	PR:000006854	denotes	E2f3
T20041	579-587	GO:0042571	denotes	antibody
T20042	640-645	PR:000028775	denotes	E2f3a
T20043	737-744	UBERON:0000966	denotes	retinal
T20044	757-762	PR:000028775	denotes	E2f3a
T20045	783-787	NCBITaxon:10088	denotes	mice
T20046	798-802	PR:000006854	denotes	E2f3
T20047	803-807	SO:0000147	denotes	exon
T20048	820-827	GO:0010467	denotes	express
T20049	1027-1032	PR:000028775	denotes	E2f3a
T20050	1036-1040	NCBITaxon:10088	denotes	mice
T20051	1089-1093	PR:000006854	denotes	E2f3
T20052	1094-1104	GO:0010467	denotes	expressing
T20053	1121-1128	UBERON:0000966	denotes	retinal
T20054	1173-1178	PR:000028775	denotes	E2f3a
T20055	1295-1300	PR:000028775	denotes	E2f3a
T20056	1321-1328	GO:0005634	denotes	nuclear
T20091	4536-4542	UBERON:0000966	denotes	retina
T20092	4549-4553	PR:000006852	denotes	E2f1
T20093	4580-4587	GO:0005634	denotes	nuclear
T20094	4592-4603	GO:0005737	denotes	cytoplasmic
T20095	4631-4636	PR:000028775	denotes	E2f3a
T20096	4658-4665	GO:0005634	denotes	nuclear
T20097	4705-4717	GO:0046983	denotes	dimerization
T20098	4727-4732	PR:000016269	denotes	Tfdp1
T20099	4748-4755	GO:0005634	denotes	nuclear
T20100	4748-4775	SO:0001528	denotes	nuclear localization signal
T20101	4796-4807	GO:0005737	denotes	cytoplasmic
T20102	4851-4857	PR:000005274	denotes	Cdkn1a
T20103	4862-4868	PR:000003090	denotes	Cdkn1b
T20104	4938-4948	GO:0007049	denotes	cell cycle
T20105	5044-5051	GO:0005634	denotes	nuclear
T37103	2301-2305	PR:000006854	denotes	E2f3
T37104	2306-2314	SO:0001060	denotes	Isoforms
T37105	2325-2335	GO:0007049	denotes	Cell Cycle
T37106	2363-2369	UBERON:0000966	denotes	Retina
T37107	2370-2377	GO:0005634	denotes	Nuclear
T37108	2382-2393	GO:0005737	denotes	cytoplasmic
T37109	2432-2439	UBERON:0000966	denotes	retinal
T37110	2432-2445	CL:0009004	denotes	retinal cells
T37111	2451-2455	NCBITaxon:10088	denotes	mice
T37112	2572-2577	PR:000028775	denotes	E2f3a
T37113	2581-2585	NCBITaxon:10088	denotes	mice
T37114	2635-2640	PR:000028775	denotes	E2f3a
T37115	2650-2651	GO:0005737	denotes	C
T37116	2653-2664	GO:0005737	denotes	cytoplasmic
T37117	2675-2676	GO:0005634	denotes	N
T37118	2678-2685	GO:0005634	denotes	nuclear
T37792	2710-2715	PR:000028775	denotes	E2f3a
T37793	2716-2723	SO:0001060	denotes	Isoform
T37794	2761-2763	PR:000013773	denotes	Rb
T37795	2802-2807	NCBITaxon:10088	denotes	mouse
T37796	2812-2817	PR:000028775	denotes	E2f3a
T37797	2845-2851	SO:0000359	denotes	floxed
T37798	2852-2856	PR:000006854	denotes	E2f3
T37799	2881-2885	PR:000006854	denotes	E2f3
T37800	2906-2911	PR:000028775	denotes	E2f3a
T37801	2915-2919	NCBITaxon:10088	denotes	mice
T37802	2933-2937	PR:000006854	denotes	E2f3
T37803	2938-2942	SO:0000147	denotes	exon
T37804	2958-2964	SO:0000188	denotes	intron
T37805	3006-3013	SO:0000112	denotes	primers
T37806	3032-3037	PR:000028775	denotes	E2f3a
T37807	3041-3046	NCBITaxon:10088	denotes	mouse
T37808	3094-3099	PR:000028775	denotes	E2f3a
T37809	3122-3128	UBERON:0000966	denotes	retina
T37810	3147-3154	SO:0000112	denotes	primers
T37811	3267-3273	UBERON:0000966	denotes	retina
T37812	3274-3283	GO:0010467	denotes	expresses
T37813	3289-3294	PR:000028775	denotes	E2f3a
T37814	3324-3329	PR:000028775	denotes	E2f3a
T37815	3333-3339	UBERON:0000966	denotes	retina
T37816	3346-3351	PR:000028775	denotes	E2f3a
T37817	3367-3376	GO:0010467	denotes	expresses
T37818	3389-3393	PR:000006854	denotes	E2f3
T37819	3397-3403	UBERON:0000966	denotes	retina
T37820	3422-3427	PR:000028775	denotes	E2f3a
T37821	3457-3466	GO:0010467	denotes	expresses
T37822	3492-3496	SO:0000147	denotes	exon
T37823	3537-3542	SO:0000704	denotes	genes
T37824	3549-3556	UBERON:0000966	denotes	retinas
T37825	3636-3643	NCBITaxon:33208	denotes	animals
T37826	3799-3801	PR:000013773	denotes	Rb
T37827	3813-3818	PR:000028775	denotes	E2f3a
T37828	3840-3847	UBERON:0000966	denotes	retinal
T37829	3910-3916	GO:0005634	denotes	nuclei
T37830	3918-3922	CHEBI:51231	denotes	DAPI
T37831	3931-3938	GO:0000279	denotes	M-phase
T37832	3972-3979	PR:000014968	denotes	Slc18a3
T37833	3987-3992	PR:000028775	denotes	E2f3a
T20089	4444-4446	PR:000013773	denotes	Rb
T20090	4463-4472	GO:0042995	denotes	processes
T20086	4344-4351	GO:0005634	denotes	nuclear
T20087	4377-4388	GO:0005737	denotes	cytoplasmic
T20088	4389-4391	PR:000013773	denotes	Rb
T20057	1333-1344	GO:0005737	denotes	cytoplasmic
T20058	1402-1409	GO:0005634	denotes	nuclear
T20059	1458-1463	PR:000028775	denotes	E2f3a
T20060	1568-1575	GO:0005634	denotes	nuclear
T20061	1615-1624	GO:0005737	denotes	cytoplasm
T20062	1661-1666	PR:000028775	denotes	E2f3a
T20063	1717-1722	PR:000028775	denotes	E2f3a
T20064	1726-1732	UBERON:0000966	denotes	retina
T20065	1758-1764	PR:000013042	denotes	Pou4f2
T20066	1768-1775	GO:0005634	denotes	nuclear
T20067	1797-1806	GO:0010467	denotes	expressed
T20068	1810-1818	UBERON:0000045	denotes	ganglion
T20069	1810-1824	CL:0000740	denotes	ganglion cells
T20070	1838-1845	GO:0005634	denotes	nuclear
T20071	1880-1891	GO:0005737	denotes	cytoplasmic
T20072	1918-1925	PR:000014968	denotes	Slc18a3
T20073	1929-1940	GO:0005737	denotes	cytoplasmic
T20074	2073-2078	PR:000028775	denotes	E2f3a
T20075	2175-2180	PR:000028775	denotes	E2f3a
T20076	2201-2210	GO:0065007	denotes	regulated
T20077	2234-2247	GO:0006412	denotes	translational
T20078	4157-4167	GO:0007049	denotes	cell cycle
T20079	4186-4193	UBERON:0000966	denotes	retinal
T20080	4186-4205	GO:0060041	denotes	retinal development
T20081	4212-4217	PR:000028775	denotes	E2f3a
T20082	4219-4221	PR:000013773	denotes	Rb
T20083	4249-4258	GO:0005737	denotes	cytoplasm
T20084	4263-4270	GO:0005634	denotes	nucleus
T20085	4309-4311	PR:000013773	denotes	Rb

2_test

Id	Subject	Object	Predicate	Lexical cue
17608565-9786999-84869003	4544-4546	9786999	denotes	38
17608565-8923205-84869004	4777-4779	8923205	denotes	54
T20769	4544-4546	9786999	denotes	38
T93368	4777-4779	8923205	denotes	54

PMC:1914394 / 36605-41678 JSONTXT

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2_test

PMC:1914394 / 36605-41678 JSON TXT