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Id Subject Object Predicate Lexical cue
T4272 3610-3614 NN denotes E2f1
T4273 3614-3616 , denotes ,
T3864 13-16 DT denotes The
T3865 17-27 NN denotes simplicity
T3866 42-47 VBZ denotes makes
T3867 28-30 IN denotes of
T3868 31-34 DT denotes the
T3869 35-41 NN denotes retina
T3870 48-50 PRP denotes it
T3871 60-66 NN denotes tissue
T3872 51-53 DT denotes an
T3873 54-59 JJ denotes ideal
T3874 67-69 TO denotes to
T3875 70-75 VB denotes study
T3876 76-88 NN denotes neurogenesis
T3877 88-89 . denotes .
T3878 89-388 sentence denotes Its development proceeds through three overlapping steps starting with retinal progenitor cell (RPC) proliferation, followed by birth of post-mitotic retinal transition cells (RTCs, also referred to as precursors), and ending with terminal differentiation of seven major cell types (Figure 1A) [1].
T3879 90-93 PRP$ denotes Its
T3880 94-105 NN denotes development
T3881 106-114 VBZ denotes proceeds
T3882 115-122 IN denotes through
T3883 123-128 CD denotes three
T3884 141-146 NNS denotes steps
T3885 129-140 VBG denotes overlapping
T3886 147-155 VBG denotes starting
T3887 156-160 IN denotes with
T3888 161-168 JJ denotes retinal
T3889 180-184 NN denotes cell
T3890 169-179 NN denotes progenitor
T3891 191-204 NN denotes proliferation
T3892 185-186 -LRB- denotes (
T3893 186-189 NN denotes RPC
T3894 189-190 -RRB- denotes )
T3895 204-206 , denotes ,
T3896 206-214 VBN denotes followed
T3897 215-217 IN denotes by
T3898 218-223 NN denotes birth
T3899 224-226 IN denotes of
T3900 227-239 JJ denotes post-mitotic
T3901 259-264 NNS denotes cells
T3902 240-247 JJ denotes retinal
T3903 248-258 NN denotes transition
T3904 265-266 -LRB- denotes (
T3905 266-270 NNS denotes RTCs
T3906 270-272 , denotes ,
T3907 272-276 RB denotes also
T3908 277-285 VBN denotes referred
T3909 286-288 IN denotes to
T3910 289-291 IN denotes as
T3911 292-302 NNS denotes precursors
T3912 302-303 -RRB- denotes )
T3913 303-305 , denotes ,
T3914 305-308 CC denotes and
T3915 309-315 VBG denotes ending
T3916 316-320 IN denotes with
T3917 321-329 JJ denotes terminal
T3918 330-345 NN denotes differentiation
T3919 346-348 IN denotes of
T3920 349-354 CD denotes seven
T3921 366-371 NNS denotes types
T3922 355-360 JJ denotes major
T3923 361-365 NN denotes cell
T3924 372-373 -LRB- denotes (
T3925 380-382 NN denotes 1A
T3926 373-379 NN denotes Figure
T3927 382-383 -RRB- denotes )
T3928 384-385 -LRB- denotes [
T3929 385-386 CD denotes 1
T3930 386-387 -RRB- denotes ]
T3931 387-388 . denotes .
T3932 388-505 sentence denotes RPCs are multipotent and exit the cell cycle to generate different RTCs at specific time periods in development [1].
T3933 389-393 NNS denotes RPCs
T3934 394-397 VBP denotes are
T3935 398-409 JJ denotes multipotent
T3936 410-413 CC denotes and
T3937 414-418 VBP denotes exit
T3938 419-422 DT denotes the
T3939 428-433 NN denotes cycle
T3940 423-427 NN denotes cell
T3941 434-436 TO denotes to
T3942 437-445 VB denotes generate
T3943 446-455 JJ denotes different
T3944 456-460 NNS denotes RTCs
T3945 461-463 IN denotes at
T3946 464-472 JJ denotes specific
T3947 478-485 NNS denotes periods
T3948 473-477 NN denotes time
T3949 486-488 IN denotes in
T3950 489-500 NN denotes development
T3951 501-502 -LRB- denotes [
T3952 502-503 CD denotes 1
T3953 503-504 -RRB- denotes ]
T3954 504-505 . denotes .
T3955 505-591 sentence denotes This process of RTC “birth” requires coupling of differentiation and cell cycle exit.
T3956 506-510 DT denotes This
T3957 511-518 NN denotes process
T3958 534-542 VBZ denotes requires
T3959 519-521 IN denotes of
T3960 522-525 NN denotes RTC
T3961 527-532 NN denotes birth
T3962 526-527 `` denotes “
T3963 532-533 '' denotes ”
T3964 543-551 NN denotes coupling
T3965 552-554 IN denotes of
T3966 555-570 NN denotes differentiation
T3967 571-574 CC denotes and
T3968 575-579 NN denotes cell
T3969 580-585 NN denotes cycle
T3970 586-590 NN denotes exit
T3971 590-591 . denotes .
T3972 591-663 sentence denotes Once born, post-mitotic RTCs migrate and form different retinal layers.
T3973 592-596 IN denotes Once
T3974 597-601 VBN denotes born
T3975 621-628 VBP denotes migrate
T3976 601-603 , denotes ,
T3977 603-615 JJ denotes post-mitotic
T3978 616-620 NNS denotes RTCs
T3979 629-632 CC denotes and
T3980 633-637 VBP denotes form
T3981 638-647 JJ denotes different
T3982 656-662 NNS denotes layers
T3983 648-655 JJ denotes retinal
T3984 662-663 . denotes .
T3985 663-925 sentence denotes Rods and cones make up the outer nuclear layer (ONL); horizontal, bipolar, and amacrine cells, as well as Müller glia cell bodies, reside in the inner nuclear layer (INL); and ganglion and displaced amacrine cells form the ganglion cell layer (GCL) (Figure 1A).
T3986 664-668 NNS denotes Rods
T3987 679-683 VBP denotes make
T3988 669-672 CC denotes and
T3989 673-678 NNS denotes cones
T3990 684-686 RP denotes up
T3991 687-690 DT denotes the
T3992 705-710 NN denotes layer
T3993 691-696 JJ denotes outer
T3994 697-704 JJ denotes nuclear
T3995 711-712 -LRB- denotes (
T3996 712-715 NN denotes ONL
T3997 715-716 -RRB- denotes )
T3998 716-717 : denotes ;
T3999 718-728 JJ denotes horizontal
T4000 752-757 NNS denotes cells
T4001 728-730 , denotes ,
T4002 730-737 JJ denotes bipolar
T4003 737-739 , denotes ,
T4004 739-742 CC denotes and
T4005 743-751 JJ denotes amacrine
T4006 795-801 VBP denotes reside
T4007 757-759 , denotes ,
T4008 759-761 RB denotes as
T4009 767-769 IN denotes as
T4010 762-766 RB denotes well
T4011 770-776 NN denotes Müller
T4012 777-781 NN denotes glia
T4013 787-793 NNS denotes bodies
T4014 782-786 NN denotes cell
T4057 984-985 -LRB- denotes (
T4058 985-988 NN denotes IPL
T4059 988-989 -RRB- denotes )
T4060 996-1004 JJ denotes synaptic
T4061 1005-1016 NNS denotes connections
T4062 1017-1027 VBG denotes separating
T4063 1028-1031 DT denotes the
T4064 1036-1039 NN denotes INL
T4065 1032-1035 NN denotes ONL
T4066 1035-1036 HYPH denotes /
T4067 1040-1043 CC denotes and
T4068 1044-1047 NN denotes INL
T4069 1048-1051 NN denotes GCL
T4070 1047-1048 HYPH denotes /
T4071 1051-1053 , denotes ,
T4072 1053-1065 RB denotes respectively
T4073 1065-1066 . denotes .
T4074 1066-1067 sentence denotes
T4143 2964-2965 -RRB- denotes ]
T4145 2966-3215 sentence denotes Rb controls the cell cycle by binding and inhibiting E2f transcription factors (E2fs) (Figure 1B), first defined as transcription factors that bind adenoviral E2 regulatory elements and subsequently shown to be critical cell cycle regulators [4,5].
T4146 2967-2969 NN denotes Rb
T4147 2970-2978 VBZ denotes controls
T4148 2979-2982 DT denotes the
T4149 2988-2993 NN denotes cycle
T4150 2983-2987 NN denotes cell
T4151 2994-2996 IN denotes by
T4152 2997-3004 VBG denotes binding
T4153 3005-3008 CC denotes and
T4154 3009-3019 VBG denotes inhibiting
T4155 3020-3023 NN denotes E2f
T4156 3038-3045 NNS denotes factors
T4157 3024-3037 NN denotes transcription
T4158 3046-3047 -LRB- denotes (
T4159 3047-3051 NNS denotes E2fs
T4160 3051-3052 -RRB- denotes )
T4161 3053-3054 -LRB- denotes (
T4162 3061-3063 NN denotes 1B
T4163 3054-3060 NN denotes Figure
T4164 3063-3064 -RRB- denotes )
T4165 3064-3066 , denotes ,
T4166 3066-3071 RB denotes first
T4167 3072-3079 VBN denotes defined
T4168 3080-3082 IN denotes as
T4169 3083-3096 NN denotes transcription
T4170 3097-3104 NNS denotes factors
T4171 3105-3109 WDT denotes that
T4172 3110-3114 VBP denotes bind
T4173 3115-3125 JJ denotes adenoviral
T4174 3140-3148 NNS denotes elements
T4175 3126-3128 NN denotes E2
T4176 3129-3139 JJ denotes regulatory
T4177 3149-3152 CC denotes and
T4178 3153-3165 RB denotes subsequently
T4179 3166-3171 VBN denotes shown
T4180 3172-3174 TO denotes to
T4181 3175-3177 VB denotes be
T4182 3178-3186 JJ denotes critical
T4183 3198-3208 NNS denotes regulators
T4184 3187-3191 NN denotes cell
T4185 3192-3197 NN denotes cycle
T4186 3209-3210 -LRB- denotes [
T4187 3212-3213 CD denotes 5
T4188 3210-3211 CD denotes 4
T4189 3211-3212 , denotes ,
T4190 3213-3214 -RRB- denotes ]
T4191 3214-3215 . denotes .
T4192 3215-3290 sentence denotes E2fs bind to DNA as heterodimers with proteins of the related Tfdp family.
T4193 3216-3220 NNS denotes E2fs
T4194 3221-3225 VBP denotes bind
T4195 3226-3228 IN denotes to
T4196 3229-3232 NN denotes DNA
T4197 3233-3235 IN denotes as
T4198 3236-3248 NNS denotes heterodimers
T4199 3249-3253 IN denotes with
T4200 3254-3262 NN denotes proteins
T4201 3263-3265 IN denotes of
T4202 3266-3269 DT denotes the
T4203 3283-3289 NN denotes family
T4204 3270-3277 VBN denotes related
T4205 3278-3282 NN denotes Tfdp
T4206 3289-3290 . denotes .
T4207 3290-3377 sentence denotes E2f1, E2f2, and E2f3a are “activating E2fs” that are required for fibroblast division.
T4208 3291-3295 NN denotes E2f1
T4209 3313-3316 VBP denotes are
T4210 3295-3297 , denotes ,
T4211 3297-3301 NN denotes E2f2
T4212 3301-3303 , denotes ,
T4213 3303-3306 CC denotes and
T4214 3307-3312 NN denotes E2f3a
T4215 3317-3318 `` denotes “
T4216 3318-3328 NN denotes activating
T4217 3329-3333 NNS denotes E2fs
T4218 3333-3334 '' denotes ”
T4219 3335-3339 WDT denotes that
T4220 3344-3352 VBN denotes required
T4221 3340-3343 VBP denotes are
T4222 3353-3356 IN denotes for
T4223 3357-3367 NN denotes fibroblast
T4224 3368-3376 NN denotes division
T4225 3376-3377 . denotes .
T4226 3377-3504 sentence denotes They are strong transcriptional activators that can drive G0 fibroblasts into cycle, and are inhibited when bound to Rb [4,5].
T4227 3378-3382 PRP denotes They
T4228 3383-3386 VBP denotes are
T4229 3387-3393 JJ denotes strong
T4230 3410-3420 NNS denotes activators
T4231 3394-3409 JJ denotes transcriptional
T4232 3421-3425 WDT denotes that
T4233 3430-3435 VB denotes drive
T4234 3426-3429 MD denotes can
T4235 3436-3438 NN denotes G0
T4236 3439-3450 NNS denotes fibroblasts
T4237 3451-3455 IN denotes into
T4238 3456-3461 NN denotes cycle
T4239 3461-3463 , denotes ,
T4240 3463-3466 CC denotes and
T4241 3467-3470 VBP denotes are
T4242 3471-3480 VBN denotes inhibited
T4243 3481-3485 WRB denotes when
T4244 3486-3491 VBN denotes bound
T4245 3492-3494 IN denotes to
T4246 3495-3497 NN denotes Rb
T4247 3498-3499 -LRB- denotes [
T4248 3501-3502 CD denotes 5
T4249 3499-3500 CD denotes 4
T4250 3500-3501 , denotes ,
T4251 3502-3503 -RRB- denotes ]
T4252 3503-3504 . denotes .
T4253 3504-3697 sentence denotes Ectopic division in Rb KO embryos can be rescued to various extents in different tissues by knocking out E2f1, E2f2, or E2f3 [6–9], but which member(s) drive division in Rb KO RTCs is unknown.
T4254 3505-3512 JJ denotes Ectopic
T4255 3513-3521 NN denotes division
T4256 3546-3553 VBN denotes rescued
T4257 3522-3524 IN denotes in
T4258 3525-3527 NN denotes Rb
T4259 3528-3530 NN denotes KO
T4260 3531-3538 NNS denotes embryos
T4261 3539-3542 MD denotes can
T4262 3543-3545 VB denotes be
T4263 3554-3556 IN denotes to
T4264 3557-3564 JJ denotes various
T4265 3565-3572 NNS denotes extents
T4266 3573-3575 IN denotes in
T4267 3576-3585 JJ denotes different
T4268 3586-3593 NNS denotes tissues
T4269 3594-3596 IN denotes by
T4270 3597-3605 VBG denotes knocking
T4271 3606-3609 RP denotes out
T4274 3616-3620 NN denotes E2f2
T4275 3620-3622 , denotes ,
T4276 3622-3624 CC denotes or
T4277 3625-3629 NN denotes E2f3
T4278 3630-3631 -LRB- denotes [
T4279 3631-3632 CD denotes 6
T4280 3632-3633 SYM denotes –
T4281 3633-3634 CD denotes 9
T4282 3634-3635 -RRB- denotes ]
T4283 3635-3637 , denotes ,
T4284 3637-3640 CC denotes but
T4285 3641-3646 WDT denotes which
T4286 3647-3653 NN denotes member
T4287 3657-3662 VBP denotes drive
T4288 3653-3654 -LRB- denotes (
T4289 3654-3655 AFX denotes s
T4290 3655-3656 -RRB- denotes )
T4291 3686-3688 VBZ denotes is
T4292 3663-3671 NN denotes division
T4293 3672-3674 IN denotes in
T4294 3675-3677 NN denotes Rb
T4295 3678-3680 NN denotes KO
T4296 3681-3685 NNS denotes RTCs
T4297 3689-3696 JJ denotes unknown
T4298 3696-3697 . denotes .
T4299 3697-3905 sentence denotes Other members of the family, such as E2f4 and E2f5, are known as “repressive E2fs” because they are weak activators and appear to be primarily involved in gene silencing in quiescent or differentiated cells.
T4300 3698-3703 JJ denotes Other
T4301 3704-3711 NNS denotes members
T4302 3754-3759 VBN denotes known
T4303 3712-3714 IN denotes of
T4304 3715-3718 DT denotes the
T4305 3719-3725 NN denotes family
T4306 3725-3727 , denotes ,
T4307 3727-3731 JJ denotes such
T4308 3732-3734 IN denotes as
T4309 3735-3739 NN denotes E2f4
T4310 3740-3743 CC denotes and
T4311 3744-3748 NN denotes E2f5
T4312 3748-3750 , denotes ,
T4313 3750-3753 VBP denotes are
T4314 3760-3762 IN denotes as
T4315 3763-3764 `` denotes “
T4316 3775-3779 NNS denotes E2fs
T4317 3764-3774 JJ denotes repressive
T4318 3779-3780 '' denotes ”
T4319 3781-3788 IN denotes because
T4320 3794-3797 VBP denotes are
T4321 3789-3793 PRP denotes they
T4322 3798-3802 JJ denotes weak
T4323 3803-3813 NNS denotes activators
T4324 3814-3817 CC denotes and
T4325 3818-3824 VBP denotes appear
T4326 3825-3827 TO denotes to
T4327 3841-3849 VBN denotes involved
T4328 3828-3830 VB denotes be
T4329 3831-3840 RB denotes primarily
T4330 3850-3852 IN denotes in
T4331 3853-3857 NN denotes gene
T4332 3858-3867 NN denotes silencing
T4333 3868-3870 IN denotes in
T4334 3871-3880 JJ denotes quiescent
T4335 3899-3904 NNS denotes cells
T4336 3881-3883 CC denotes or
T4337 3884-3898 VBN denotes differentiated
T4338 3904-3905 . denotes .
T4339 3905-3981 sentence denotes Activating E2fs may also promote apoptosis in the Rb KO retina (Figure 1B).
T4340 3906-3916 VBG denotes Activating
T4341 3931-3938 VB denotes promote
T4342 3917-3921 NNS denotes E2fs
T4343 3922-3925 MD denotes may
T4344 3926-3930 RB denotes also
T4345 3939-3948 NN denotes apoptosis
T4346 3949-3951 IN denotes in
T4347 3952-3955 DT denotes the
T4348 3962-3968 NN denotes retina
T4349 3956-3958 NN denotes Rb
T4350 3959-3961 NN denotes KO
T4351 3969-3970 -LRB- denotes (
T4352 3977-3979 NN denotes 1B
T4353 3970-3976 NN denotes Figure
T4354 3979-3980 -RRB- denotes )
T4355 3980-3981 . denotes .
T4356 3981-4066 sentence denotes Originally, E2f1 was considered the primary pro-apoptotic member of the family [10].
T4357 3982-3992 RB denotes Originally
T4358 4003-4013 VBN denotes considered
T4359 3992-3994 , denotes ,
T4360 3994-3998 NN denotes E2f1
T4361 3999-4002 VBD denotes was
T4362 4014-4017 DT denotes the
T4363 4040-4046 NN denotes member
T4364 4018-4025 JJ denotes primary
T4365 4026-4039 JJ denotes pro-apoptotic
T4366 4047-4049 IN denotes of
T4367 4050-4053 DT denotes the
T4368 4054-4060 NN denotes family
T4369 4061-4062 -LRB- denotes [
T4370 4062-4064 CD denotes 10
T4371 4064-4065 -RRB- denotes ]
T4372 4065-4066 . denotes .
T4373 4066-4243 sentence denotes However, this view was reevaluated when it was shown that either E2f1 or E2f3 deletion rescues apoptosis in the developing central nervous system (CNS) of Rb KO embryos [6,11].
T4374 4067-4074 RB denotes However
T4375 4090-4101 VBN denotes reevaluated
T4376 4074-4076 , denotes ,
T4377 4076-4080 DT denotes this
T4378 4081-4085 NN denotes view
T4379 4086-4089 VBD denotes was
T4380 4102-4106 WRB denotes when
T4381 4114-4119 VBN denotes shown
T4382 4107-4109 PRP denotes it
T4383 4110-4113 VBD denotes was
T4384 4120-4124 IN denotes that
T4385 4154-4161 VBZ denotes rescues
T4386 4125-4131 CC denotes either
T4387 4132-4136 NN denotes E2f1
T4388 4145-4153 NN denotes deletion
T4389 4137-4139 CC denotes or
T4390 4140-4144 NN denotes E2f3
T4391 4162-4171 NN denotes apoptosis
T4392 4172-4174 IN denotes in
T4393 4175-4178 DT denotes the
T4394 4206-4212 NN denotes system
T4395 4179-4189 VBG denotes developing
T4396 4190-4197 JJ denotes central
T4397 4198-4205 JJ denotes nervous
T4398 4213-4214 -LRB- denotes (
T4399 4214-4217 NN denotes CNS
T4400 4217-4218 -RRB- denotes )
T4401 4219-4221 IN denotes of
T4402 4222-4224 NN denotes Rb
T4403 4225-4227 NN denotes KO
T4404 4228-4235 NNS denotes embryos
T4405 4236-4237 -LRB- denotes [
T4406 4239-4241 CD denotes 11
T4407 4237-4238 CD denotes 6
T4408 4238-4239 , denotes ,
T4409 4241-4242 -RRB- denotes ]
T4410 4242-4243 . denotes .
T4411 4243-4357 sentence denotes Subsequently, CNS apoptosis was shown to be an indirect result of placental defects and probable hypoxia [12–14].
T4412 4244-4256 RB denotes Subsequently
T4413 4276-4281 VBN denotes shown
T4414 4256-4258 , denotes ,
T4415 4258-4261 NN denotes CNS
T4416 4262-4271 NN denotes apoptosis
T4417 4272-4275 VBD denotes was
T4418 4282-4284 TO denotes to
T4419 4285-4287 VB denotes be
T4420 4288-4290 DT denotes an
T4421 4300-4306 NN denotes result
T4422 4291-4299 JJ denotes indirect
T4423 4307-4309 IN denotes of
T4424 4310-4319 JJ denotes placental
T4425 4320-4327 NNS denotes defects
T4426 4328-4331 CC denotes and
T4427 4332-4340 JJ denotes probable
T4428 4341-4348 NN denotes hypoxia
T4429 4349-4350 -LRB- denotes [
T4430 4350-4352 CD denotes 12
T4431 4352-4353 SYM denotes –
T4432 4353-4355 CD denotes 14
T4433 4355-4356 -RRB- denotes ]
T4434 4356-4357 . denotes .
T4435 4357-4449 sentence denotes Indeed, E2f3-induced apoptosis in fibroblasts has recently been shown to require E2f1 [15].
T4436 4358-4364 RB denotes Indeed
T4437 4422-4427 VBN denotes shown
T4438 4364-4366 , denotes ,
T4439 4366-4370 NN denotes E2f3
T4440 4371-4378 VBN denotes induced
T4441 4370-4371 HYPH denotes -
T4442 4379-4388 NN denotes apoptosis
T4443 4389-4391 IN denotes in
T4444 4392-4403 NNS denotes fibroblasts
T4445 4404-4407 VBZ denotes has
T4446 4408-4416 RB denotes recently
T4447 4417-4421 VBN denotes been
T4448 4428-4430 TO denotes to
T4449 4431-4438 VB denotes require
T4450 4439-4443 NN denotes E2f1
T4451 4444-4445 -LRB- denotes [
T4452 4445-4447 CD denotes 15
T4453 4447-4448 -RRB- denotes ]
T4454 4448-4449 . denotes .
T4455 4449-4538 sentence denotes Thus, it is controversial whether E2f3 is required for apoptosis of any Rb KO cell type.
T4456 4450-4454 RB denotes Thus
T4457 4459-4461 VBZ denotes is
T4458 4454-4456 , denotes ,
T4459 4456-4458 PRP denotes it
T4460 4462-4475 JJ denotes controversial
T4461 4476-4483 IN denotes whether
T4462 4492-4500 VBN denotes required
T4463 4484-4488 NN denotes E2f3
T4464 4489-4491 VBZ denotes is
T4465 4501-4504 IN denotes for
T4466 4505-4514 NN denotes apoptosis
T4467 4515-4517 IN denotes of
T4468 4518-4521 DT denotes any
T4469 4533-4537 NN denotes type
T4470 4522-4524 NN denotes Rb
T4471 4525-4527 NN denotes KO
T4472 4528-4532 NN denotes cell
T4473 4537-4538 . denotes .
T4474 4538-4732 sentence denotes Determining which activating E2fs promote death in distinct Rb KO tissues requires conditional rather than germ line models of Rb deletion to avoid secondary indirect effects (such as hypoxia).
T4475 4539-4550 VBG denotes Determining
T4476 4613-4621 VBZ denotes requires
T4477 4551-4556 WDT denotes which
T4478 4568-4572 NNS denotes E2fs
T4479 4557-4567 VBG denotes activating
T4480 4573-4580 VBP denotes promote
T4481 4581-4586 NN denotes death
T4482 4587-4589 IN denotes in
T4483 4590-4598 JJ denotes distinct
T4484 4605-4612 NNS denotes tissues
T4485 4599-4601 NN denotes Rb
T4486 4602-4604 NN denotes KO
T4487 4622-4633 JJ denotes conditional
T4488 4656-4662 NNS denotes models
T4489 4634-4640 RB denotes rather
T4490 4641-4645 IN denotes than
T4491 4646-4650 NN denotes germ
T4492 4651-4655 NN denotes line
T4493 4663-4665 IN denotes of
T4494 4666-4668 NN denotes Rb
T4495 4669-4677 NN denotes deletion
T4496 4678-4680 TO denotes to
T4497 4681-4686 VB denotes avoid
T4498 4687-4696 JJ denotes secondary
T4499 4706-4713 NNS denotes effects
T4500 4697-4705 JJ denotes indirect
T4501 4714-4715 -LRB- denotes (
T4502 4715-4719 JJ denotes such
T4503 4720-4722 IN denotes as
T4504 4723-4730 NN denotes hypoxia
T4505 4730-4731 -RRB- denotes )
T4506 4731-4732 . denotes .
T4507 4732-4783 sentence denotes E2f family diversity is expanded by E2f3 isoforms.
T4508 4733-4736 NN denotes E2f
T4509 4744-4753 NN denotes diversity
T4510 4737-4743 NN denotes family
T4511 4757-4765 VBN denotes expanded
T4512 4754-4756 VBZ denotes is
T4513 4766-4768 IN denotes by
T4514 4769-4773 NN denotes E2f3
T4515 4774-4782 NNS denotes isoforms
T4516 4782-4783 . denotes .
T4517 4783-4891 sentence denotes Alternative promoters generate two forms (a and b) that are identical except for distinct first exons [16].
T4518 4784-4795 JJ denotes Alternative
T4519 4796-4805 NNS denotes promoters
T4520 4806-4814 VBP denotes generate
T4521 4815-4818 CD denotes two
T4522 4819-4824 NNS denotes forms
T4523 4825-4826 -LRB- denotes (
T4524 4826-4827 NN denotes a
T4525 4828-4831 CC denotes and
T4526 4832-4833 NN denotes b
T4527 4833-4834 -RRB- denotes )
T4528 4835-4839 WDT denotes that
T4529 4840-4843 VBP denotes are
T4530 4844-4853 JJ denotes identical
T4531 4854-4860 IN denotes except
T4532 4861-4864 IN denotes for
T4533 4865-4873 JJ denotes distinct
T4534 4880-4885 NNS denotes exons
T4535 4874-4879 JJ denotes first
T4536 4886-4887 -LRB- denotes [
T4537 4887-4889 CD denotes 16
T4538 4889-4890 -RRB- denotes ]
T4539 4890-4891 . denotes .
T4540 4891-5031 sentence denotes E2f3a is a strong activator, and, like other activating E2fs, its expression is induced when quiescent cells are stimulated to divide [16].
T4541 4892-4897 NN denotes E2f3a
T4542 4898-4900 VBZ denotes is
T4543 4901-4902 DT denotes a
T4544 4910-4919 NN denotes activator
T4545 4903-4909 JJ denotes strong
T4546 4919-4921 , denotes ,
T4547 4921-4924 CC denotes and
T4548 4924-4926 , denotes ,
T4549 4926-4930 IN denotes like
T4550 4972-4979 VBN denotes induced
T4551 4931-4936 JJ denotes other
T4552 4948-4952 NNS denotes E2fs
T4553 4937-4947 VBG denotes activating
T4554 4952-4954 , denotes ,
T4555 4954-4957 PRP$ denotes its
T4556 4958-4968 NN denotes expression
T4557 4969-4971 VBZ denotes is
T4558 4980-4984 WRB denotes when
T4559 5005-5015 VBN denotes stimulated
T4560 4985-4994 JJ denotes quiescent
T4561 4995-5000 NNS denotes cells
T4562 5001-5004 VBP denotes are
T4563 5016-5018 TO denotes to
T4564 5019-5025 VB denotes divide
T4565 5026-5027 -LRB- denotes [
T4566 5027-5029 CD denotes 16
T4567 5029-5030 -RRB- denotes ]
T4568 5030-5031 . denotes .
T4569 5031-5219 sentence denotes E2f3b, like repressive E2fs, is present in both quiescent and dividing cells, and in quiescent fibroblasts it associates primarily with Rb, suggesting that it mediates repression [16–18].
T4570 5032-5037 NN denotes E2f3b
T4571 5061-5063 VBZ denotes is
T4572 5037-5039 , denotes ,
T4573 5039-5043 IN denotes like
T4574 5044-5054 JJ denotes repressive
T4575 5055-5059 NNS denotes E2fs
T4576 5059-5061 , denotes ,
T4577 5064-5071 JJ denotes present
T4578 5072-5074 IN denotes in
T4579 5075-5079 CC denotes both
T4580 5080-5089 JJ denotes quiescent
T4581 5103-5108 NNS denotes cells
T4583 5094-5102 VBG denotes dividing
T4584 5108-5110 , denotes ,
T4585 5110-5113 CC denotes and
T4586 5114-5116 IN denotes in
T4587 5142-5152 VBZ denotes associates
T4588 5117-5126 JJ denotes quiescent
T4589 5127-5138 NNS denotes fibroblasts
T4590 5139-5141 PRP denotes it
T4591 5153-5162 RB denotes primarily
T4592 5163-5167 IN denotes with
T4593 5168-5170 NN denotes Rb
T4594 5170-5172 , denotes ,
T4595 5172-5182 VBG denotes suggesting
T4596 5183-5187 IN denotes that
T4597 5191-5199 VBZ denotes mediates
T4598 5188-5190 PRP denotes it
T4599 5200-5210 NN denotes repression
T4600 5211-5212 -LRB- denotes [
T4601 5212-5214 CD denotes 16
T4602 5214-5215 SYM denotes –
T4603 5215-5217 CD denotes 18
T4604 5217-5218 -RRB- denotes ]
T4605 5218-5219 . denotes .
T4606 5219-5305 sentence denotes Indeed, silencing the Cdkn2d (p19Arf) locus in unstressed cells relies on E2f3b [19].
T4607 5220-5226 RB denotes Indeed
T4608 5284-5290 VBZ denotes relies
T4609 5226-5228 , denotes ,
T4610 5228-5237 VBG denotes silencing
T4611 5238-5241 DT denotes the
T4612 5258-5263 NN denotes locus
T4613 5242-5248 NN denotes Cdkn2d
T4614 5249-5250 -LRB- denotes (
T4615 5250-5256 NN denotes p19Arf
T4616 5256-5257 -RRB- denotes )
T4617 5264-5266 IN denotes in
T4618 5267-5277 JJ denotes unstressed
T4619 5278-5283 NNS denotes cells
T4620 5291-5293 IN denotes on
T4621 5294-5299 NN denotes E2f3b
T4622 5300-5301 -LRB- denotes [
T4623 5301-5303 CD denotes 19
T4624 5303-5304 -RRB- denotes ]
T4625 5304-5305 . denotes .
T4626 5305-5418 sentence denotes Other E2fs may also exist in isoforms since at least two mRNA species have been detected for E2f1 and E2f2 [16].
T4627 5306-5311 JJ denotes Other
T4628 5312-5316 NNS denotes E2fs
T4629 5326-5331 VB denotes exist
T4630 5317-5320 MD denotes may
T4631 5321-5325 RB denotes also
T4632 5332-5334 IN denotes in
T4633 5335-5343 NNS denotes isoforms
T4634 5344-5349 IN denotes since
T4635 5386-5394 VBN denotes detected
T4636 5350-5352 RB denotes at
T4637 5359-5362 CD denotes two
T4638 5353-5358 RBS denotes least
T4639 5363-5367 NN denotes mRNA
T4640 5368-5375 NNS denotes species
T4641 5376-5380 VBP denotes have
T4642 5381-5385 VBN denotes been
T4643 5395-5398 IN denotes for
T4644 5399-5403 NN denotes E2f1
T4645 5404-5407 CC denotes and
T4646 5408-5412 NN denotes E2f2
T4647 5413-5414 -LRB- denotes [
T4648 5414-5416 CD denotes 16
T4649 5416-5417 -RRB- denotes ]
T4650 5417-5418 . denotes .
T4651 5418-5465 sentence denotes The roles of E2f isoforms in vivo are unknown.
T4652 5419-5422 DT denotes The
T4653 5423-5428 NNS denotes roles
T4654 5453-5456 VBP denotes are
T4655 5429-5431 IN denotes of
T4656 5432-5435 NN denotes E2f
T4657 5436-5444 NNS denotes isoforms
T4658 5445-5447 FW denotes in
T4659 5448-5452 FW denotes vivo
T4660 5457-5464 JJ denotes unknown
T4661 5464-5465 . denotes .
T4662 5465-5518 sentence denotes E2fs are also regulated by subcellular localization.
T4663 5466-5470 NNS denotes E2fs
T4664 5480-5489 VBN denotes regulated
T4665 5471-5474 VBP denotes are
T4666 5475-5479 RB denotes also
T4667 5490-5492 IN denotes by
T4668 5493-5504 JJ denotes subcellular
T4669 5505-5517 NN denotes localization
T4670 5517-5518 . denotes .
T4671 5518-5638 sentence denotes Although this feature has been best characterized for repressive E2fs [20–22], it also affects activating E2fs [23–25].
T4672 5519-5527 IN denotes Although
T4673 5555-5568 VBN denotes characterized
T4674 5528-5532 DT denotes this
T4675 5533-5540 NN denotes feature
T4676 5541-5544 VBZ denotes has
T4677 5545-5549 VBN denotes been
T4678 5550-5554 RBS denotes best
T4679 5606-5613 VBZ denotes affects
T4680 5569-5572 IN denotes for
T4681 5573-5583 JJ denotes repressive
T4682 5584-5588 NNS denotes E2fs
T4683 5589-5590 -LRB- denotes [
T4684 5590-5592 CD denotes 20
T4685 5592-5593 SYM denotes –
T4686 5593-5595 CD denotes 22
T4687 5595-5596 -RRB- denotes ]
T4688 5596-5598 , denotes ,
T4689 5598-5600 PRP denotes it
T4690 5601-5605 RB denotes also
T4691 5614-5624 VBG denotes activating
T4692 5625-5629 NNS denotes E2fs
T4693 5630-5631 -LRB- denotes [
T4694 5631-5633 CD denotes 23
T4695 5633-5634 SYM denotes –
T4696 5634-5636 CD denotes 25
T4697 5636-5637 -RRB- denotes ]
T4698 5637-5638 . denotes .
T4699 5638-5696 sentence denotes The distribution of E2f isoforms has never been assessed.
T4700 5639-5642 DT denotes The
T4701 5643-5655 NN denotes distribution
T4702 5687-5695 VBN denotes assessed
T4703 5656-5658 IN denotes of
T4704 5659-5662 NN denotes E2f
T4705 5663-5671 NNS denotes isoforms
T4706 5672-5675 VBZ denotes has
T4707 5676-5681 RB denotes never
T4708 5682-5686 VBN denotes been
T4709 5695-5696 . denotes .
T4710 5696-5785 sentence denotes It has been known for many years that Rb loss perturbs neuronal differentiation [26–29].
T4711 5697-5699 PRP denotes It
T4712 5709-5714 VBN denotes known
T4713 5700-5703 VBZ denotes has
T4714 5704-5708 VBN denotes been
T4715 5715-5718 IN denotes for
T4716 5719-5723 JJ denotes many
T4717 5724-5729 NNS denotes years
T4718 5730-5734 IN denotes that
T4719 5743-5751 VBZ denotes perturbs
T4720 5735-5737 NN denotes Rb
T4721 5738-5742 NN denotes loss
T4722 5752-5760 JJ denotes neuronal
T4723 5761-5776 NN denotes differentiation
T4724 5777-5778 -LRB- denotes [
T4725 5778-5780 CD denotes 26
T4726 5780-5781 SYM denotes –
T4727 5781-5783 CD denotes 29
T4728 5783-5784 -RRB- denotes ]
T4729 5784-5785 . denotes .
T4730 5785-5935 sentence denotes However, prior work could not exclude the possibility that differentiation defects are simply an indirect consequence of abnormal division and death.
T4731 5786-5793 RB denotes However
T4732 5816-5823 VB denotes exclude
T4733 5793-5795 , denotes ,
T4734 5795-5800 JJ denotes prior
T4735 5801-5805 NN denotes work
T4736 5806-5811 MD denotes could
T4737 5812-5815 RB denotes not
T4738 5824-5827 DT denotes the
T4739 5828-5839 NN denotes possibility
T4740 5840-5844 IN denotes that
T4741 5869-5872 VBP denotes are
T4742 5845-5860 NN denotes differentiation
T4743 5861-5868 NNS denotes defects
T4744 5873-5879 RB denotes simply
T4745 5880-5882 DT denotes an
T4746 5892-5903 NN denotes consequence
T4747 5883-5891 JJ denotes indirect
T4748 5904-5906 IN denotes of
T4749 5907-5915 JJ denotes abnormal
T4750 5916-5924 NN denotes division
T4751 5925-5928 CC denotes and
T4752 5929-5934 NN denotes death
T4753 5934-5935 . denotes .
T4754 5935-6044 sentence denotes If Rb does regulate differentiation directly it is unclear whether it does so in all or a subset of neurons.
T4755 5936-5938 IN denotes If
T4756 5947-5955 VB denotes regulate
T4757 5939-5941 NN denotes Rb
T4758 5942-5946 VBZ denotes does
T4759 5984-5986 VBZ denotes is
T4760 5956-5971 NN denotes differentiation
T4761 5972-5980 RB denotes directly
T4762 5981-5983 PRP denotes it
T4763 5987-5994 JJ denotes unclear
T4764 5995-6002 IN denotes whether
T4765 6006-6010 VBZ denotes does
T4766 6003-6005 PRP denotes it
T4767 6011-6013 RB denotes so
T4768 6014-6016 IN denotes in
T4769 6017-6020 DT denotes all
T4770 6021-6023 CC denotes or
T4771 6024-6025 DT denotes a
T4772 6026-6032 NN denotes subset
T4773 6036-6043 NNS denotes neurons
T4774 6033-6035 IN denotes of
T4775 6043-6044 . denotes .
T4776 6044-6091 sentence denotes Moreover, the mechanism has never been solved.
T4777 6045-6053 RB denotes Moreover
T4778 6084-6090 VBN denotes solved
T4779 6053-6055 , denotes ,
T4780 6055-6058 DT denotes the
T4781 6059-6068 NN denotes mechanism
T4782 6069-6072 VBZ denotes has
T4783 6073-6078 RB denotes never
T4784 6079-6083 VBN denotes been
T4785 6090-6091 . denotes .
T4786 6091-6306 sentence denotes In other cell types where Rb may promote differentiation directly, such as muscle and bone, it seems to do so through E2f-independent means by potentiating tissue-specific transcription factors (Figure 1B) [30–33].
T4787 6092-6094 IN denotes In
T4788 6187-6192 VBZ denotes seems
T4789 6095-6100 JJ denotes other
T4790 6106-6111 NNS denotes types
T4791 6101-6105 NN denotes cell
T4792 6112-6117 WRB denotes where
T4793 6125-6132 VB denotes promote
T4794 6118-6120 NN denotes Rb
T4795 6121-6124 MD denotes may
T4796 6133-6148 NN denotes differentiation
T4797 6149-6157 RB denotes directly
T4798 6157-6159 , denotes ,
T4799 6159-6163 JJ denotes such
T4800 6164-6166 IN denotes as
T4801 6167-6173 NN denotes muscle
T4802 6174-6177 CC denotes and
T4803 6178-6182 NN denotes bone
T4804 6182-6184 , denotes ,
T4805 6184-6186 PRP denotes it
T4806 6193-6195 TO denotes to
T4807 6196-6198 VB denotes do
T4808 6199-6201 RB denotes so
T4809 6202-6209 IN denotes through
T4810 6210-6213 NN denotes E2f
T4811 6214-6225 JJ denotes independent
T4812 6213-6214 HYPH denotes -
T4813 6226-6231 NNS denotes means
T4814 6232-6234 IN denotes by
T4815 6235-6247 VBG denotes potentiating
T4816 6248-6254 NN denotes tissue
T4817 6255-6263 JJ denotes specific
T4818 6254-6255 HYPH denotes -
T4819 6278-6285 NNS denotes factors
T4820 6264-6277 NN denotes transcription
T4821 6286-6287 -LRB- denotes (
T4822 6294-6296 NN denotes 1B
T4823 6287-6293 NN denotes Figure
T4824 6296-6297 -RRB- denotes )
T4825 6298-6299 -LRB- denotes [
T4826 6299-6301 CD denotes 30
T4827 6301-6302 SYM denotes –
T4828 6302-6304 CD denotes 33
T4829 6304-6305 -RRB- denotes ]
T4830 6305-6306 . denotes .
T4831 6306-6475 sentence denotes In the retina, others have noted abnormally shaped Rb KO rods and have suggested Rb may directly promote their morphogenesis by activating retina-specific factors [29].
T4832 6307-6309 IN denotes In
T4833 6334-6339 VBN denotes noted
T4834 6310-6313 DT denotes the
T4835 6314-6320 NN denotes retina
T4836 6320-6322 , denotes ,
T4837 6322-6328 NNS denotes others
T4838 6329-6333 VBP denotes have
T4839 6340-6350 RB denotes abnormally
T4840 6351-6357 VBN denotes shaped
T4841 6364-6368 NNS denotes rods
T4842 6358-6360 NN denotes Rb
T4843 6361-6363 NN denotes KO
T4844 6369-6372 CC denotes and
T4845 6373-6377 VBP denotes have
T4846 6378-6387 VBN denotes suggested
T4847 6388-6390 NN denotes Rb
T4848 6404-6411 VB denotes promote
T4849 6391-6394 MD denotes may
T4850 6395-6403 RB denotes directly
T4851 6412-6417 PRP$ denotes their
T4852 6418-6431 NN denotes morphogenesis
T4853 6432-6434 IN denotes by
T4854 6435-6445 VBG denotes activating
T4855 6446-6452 NN denotes retina
T4856 6453-6461 JJ denotes specific
T4857 6452-6453 HYPH denotes -
T4858 6462-6469 NNS denotes factors
T4859 6470-6471 -LRB- denotes [
T4860 6471-6473 CD denotes 29
T4861 6473-6474 -RRB- denotes ]
T4862 6474-6475 . denotes .
T4863 6475-6606 sentence denotes However, differentiation defects in any Rb KO neuron could be an indirect effect of ectopic division and/or apoptosis (Figure 1B).
T4864 6476-6483 RB denotes However
T4865 6535-6537 VB denotes be
T4866 6483-6485 , denotes ,
T4867 6485-6500 NN denotes differentiation
T4868 6501-6508 NNS denotes defects
T4869 6509-6511 IN denotes in
T4870 6512-6515 DT denotes any
T4871 6522-6528 NN denotes neuron
T4872 6516-6518 NN denotes Rb
T4873 6519-6521 NN denotes KO
T4874 6529-6534 MD denotes could
T4875 6538-6540 DT denotes an
T4876 6550-6556 NN denotes effect
T4877 6541-6549 JJ denotes indirect
T4878 6557-6559 IN denotes of
T4879 6560-6567 JJ denotes ectopic
T4880 6568-6576 NN denotes division
T4881 6577-6580 CC denotes and
T4882 6580-6581 HYPH denotes /
T4883 6581-6583 CC denotes or
T4884 6584-6593 NN denotes apoptosis
T4885 6594-6595 -LRB- denotes (
T4886 6602-6604 NN denotes 1B
T4887 6595-6601 NN denotes Figure
T4888 6604-6605 -RRB- denotes )
T4889 6605-6606 . denotes .
T4890 6606-6718 sentence denotes Thus, it is critical to study differentiation of Rb KO cells in the absence of ectopic proliferation and death.
T4891 6607-6611 RB denotes Thus
T4892 6616-6618 VBZ denotes is
T4893 6611-6613 , denotes ,
T4894 6613-6615 PRP denotes it
T4895 6619-6627 JJ denotes critical
T4896 6628-6630 TO denotes to
T4897 6631-6636 VB denotes study
T4898 6637-6652 NN denotes differentiation
T4899 6653-6655 IN denotes of
T4900 6656-6658 NN denotes Rb
T4901 6659-6661 NN denotes KO
T4902 6662-6667 NNS denotes cells
T4903 6668-6670 IN denotes in
T4904 6671-6674 DT denotes the
T4905 6675-6682 NN denotes absence
T4906 6683-6685 IN denotes of
T4907 6686-6693 JJ denotes ectopic
T4908 6694-6707 NN denotes proliferation
T4909 6708-6711 CC denotes and
T4910 6712-6717 NN denotes death
T4911 6717-6718 . denotes .
T4912 6718-6817 sentence denotes Here, we establish that Rb suppresses RTC division and death by inhibiting E2f1, not E2f2 or E2f3.
T4913 6719-6723 RB denotes Here
T4914 6728-6737 VBP denotes establish
T4915 6723-6725 , denotes ,
T4916 6725-6727 PRP denotes we
T4917 6738-6742 IN denotes that
T4918 6746-6756 VBZ denotes suppresses
T4919 6743-6745 NN denotes Rb
T4920 6757-6760 NN denotes RTC
T4921 6761-6769 NN denotes division
T4922 6770-6773 CC denotes and
T4923 6774-6779 NN denotes death
T4924 6780-6782 IN denotes by
T4925 6783-6793 VBG denotes inhibiting
T4926 6794-6798 NN denotes E2f1
T4927 6798-6800 , denotes ,
T4928 6800-6803 CC denotes not
T4929 6804-6808 NN denotes E2f2
T4930 6809-6811 CC denotes or
T4931 6812-6816 NN denotes E2f3
T4932 6816-6817 . denotes .
T4933 6817-6939 sentence denotes When these defects were rescued, most retinal neurons, including rods, survived, differentiated, and functioned normally.
T4934 6818-6822 WRB denotes When
T4935 6842-6849 VBN denotes rescued
T4936 6823-6828 DT denotes these
T4937 6829-6836 NNS denotes defects
T4938 6837-6841 VBD denotes were
T4939 6889-6897 VBD denotes survived
T4940 6849-6851 , denotes ,
T4941 6851-6855 RBS denotes most
T4942 6864-6871 NNS denotes neurons
T4943 6856-6863 JJ denotes retinal
T4944 6871-6873 , denotes ,
T4945 6873-6882 VBG denotes including
T4946 6883-6887 NNS denotes rods
T4947 6887-6889 , denotes ,
T4948 6897-6899 , denotes ,
T4949 6899-6913 VBD denotes differentiated
T4950 6913-6915 , denotes ,
T4951 6915-6918 CC denotes and
T4952 6919-6929 VBD denotes functioned
T4953 6930-6938 RB denotes normally
T4954 6938-6939 . denotes .
T4955 6939-7029 sentence denotes Thus, unexpectedly, retina-specific differentiation factors function independently of Rb.
T4956 6940-6944 RB denotes Thus
T4957 7000-7008 VBP denotes function
T4958 6944-6946 , denotes ,
T4959 6946-6958 RB denotes unexpectedly
T4960 6958-6960 , denotes ,
T4961 6960-6966 NN denotes retina
T4962 6967-6975 JJ denotes specific
T4963 6966-6967 HYPH denotes -
T4964 6992-6999 NNS denotes factors
T4965 6976-6991 NN denotes differentiation
T4966 7009-7022 RB denotes independently
T4967 7023-7025 IN denotes of
T4968 7026-7028 NN denotes Rb
T4969 7028-7029 . denotes .
T4970 7029-7187 sentence denotes However, comprehensive assessment of the Rb/E2f1 double-null rescued retina revealed a differentiation defect in cholinergic starburst amacrine cells (SACs).
T4971 7030-7037 RB denotes However
T4972 7106-7114 VBD denotes revealed
T4973 7037-7039 , denotes ,
T4974 7039-7052 JJ denotes comprehensive
T4975 7053-7063 NN denotes assessment
T4976 7064-7066 IN denotes of
T4977 7067-7070 DT denotes the
T4978 7099-7105 NN denotes retina
T4979 7071-7073 NN denotes Rb
T4980 7074-7078 NN denotes E2f1
T4981 7073-7074 HYPH denotes /
T4982 7086-7090 JJ denotes null
T4983 7079-7085 JJ denotes double
T4984 7085-7086 HYPH denotes -
T4985 7091-7098 VBN denotes rescued
T4986 7115-7116 DT denotes a
T4987 7133-7139 NN denotes defect
T4988 7117-7132 NN denotes differentiation
T4989 7140-7142 IN denotes in
T4990 7143-7154 JJ denotes cholinergic
T4991 7174-7179 NNS denotes cells
T4992 7155-7164 NN denotes starburst
T4993 7165-7173 JJ denotes amacrine
T4994 7180-7181 -LRB- denotes (
T4995 7181-7185 NNS denotes SACs
T4996 7185-7186 -RRB- denotes )
T4997 7186-7187 . denotes .
T4998 7187-7340 sentence denotes Recent breakthroughs have revealed that these interneurons are critical for direction selectivity and developmentally important rhythmic bursts [34–36].
T4999 7188-7194 JJ denotes Recent
T5000 7195-7208 NNS denotes breakthroughs
T5001 7214-7222 VBN denotes revealed
T5002 7209-7213 VBP denotes have
T5003 7223-7227 IN denotes that
T5004 7247-7250 VBP denotes are
T5005 7228-7233 DT denotes these
T5006 7234-7246 NNS denotes interneurons
T5007 7251-7259 JJ denotes critical
T5008 7260-7263 IN denotes for
T5009 7264-7273 NN denotes direction
T5010 7274-7285 NN denotes selectivity
T5011 7286-7289 CC denotes and
T5012 7290-7305 RB denotes developmentally
T5013 7306-7315 JJ denotes important
T5014 7325-7331 NNS denotes bursts
T5015 7316-7324 JJ denotes rhythmic
T5016 7332-7333 -LRB- denotes [
T5017 7333-7335 CD denotes 34
T5018 7335-7336 SYM denotes –
T5019 7336-7338 CD denotes 36
T5020 7338-7339 -RRB- denotes ]
T5021 7339-7340 . denotes .
T5022 7340-7393 sentence denotes However, their differentiation is poorly understood.
T5023 7341-7348 RB denotes However
T5024 7382-7392 VBN denotes understood
T5025 7348-7350 , denotes ,
T5026 7350-7355 PRP$ denotes their
T5027 7356-7371 NN denotes differentiation
T5028 7372-7374 VBZ denotes is
T5029 7375-7381 RB denotes poorly
T5030 7392-7393 . denotes .
T5031 7393-7579 sentence denotes Contrary to the prevailing view that Rb promotes differentiation through E2f-independent tissue-specific transcription factors, we show that Rb facilitates SAC development through E2f3.
T5032 7394-7402 JJ denotes Contrary
T5033 7525-7529 VBP denotes show
T5034 7403-7405 IN denotes to
T5035 7406-7409 DT denotes the
T5036 7421-7425 NN denotes view
T5037 7410-7420 VBG denotes prevailing
T5038 7426-7430 IN denotes that
T5039 7434-7442 VBZ denotes promotes
T5040 7431-7433 NN denotes Rb
T5041 7443-7458 NN denotes differentiation
T5042 7459-7466 IN denotes through
T5043 7467-7470 NN denotes E2f
T5044 7471-7482 JJ denotes independent
T5045 7470-7471 HYPH denotes -
T5046 7513-7520 NNS denotes factors
T5047 7483-7489 NN denotes tissue
T5048 7490-7498 JJ denotes specific
T5049 7489-7490 HYPH denotes -
T5050 7499-7512 NN denotes transcription
T5051 7520-7522 , denotes ,
T5052 7522-7524 PRP denotes we
T5053 7530-7534 IN denotes that
T5054 7538-7549 VBZ denotes facilitates
T5055 7535-7537 NN denotes Rb
T5056 7550-7553 NN denotes SAC
T5057 7554-7565 NN denotes development
T5058 7566-7573 IN denotes through
T5059 7574-7578 NN denotes E2f3
T5060 7578-7579 . denotes .
T5061 7579-7734 sentence denotes Defects in Rb null SACs correlated with specific E2f3 expression in these cells, and E2f3 expression was absent in neurons that differentiated without Rb.
T5062 7580-7587 NNS denotes Defects
T5063 7604-7614 VBD denotes correlated
T5064 7588-7590 IN denotes in
T5065 7591-7593 NN denotes Rb
T5066 7594-7598 JJ denotes null
T5067 7599-7603 NNS denotes SACs
T5068 7615-7619 IN denotes with
T5069 7620-7628 JJ denotes specific
T5070 7634-7644 NN denotes expression
T5071 7629-7633 NN denotes E2f3
T5072 7645-7647 IN denotes in
T5073 7648-7653 DT denotes these
T5074 7654-7659 NNS denotes cells
T5075 7659-7661 , denotes ,
T5076 7661-7664 CC denotes and
T5077 7665-7669 NN denotes E2f3
T5078 7670-7680 NN denotes expression
T5079 7681-7684 VBD denotes was
T5080 7685-7691 JJ denotes absent
T5081 7692-7694 IN denotes in
T5082 7695-7702 NNS denotes neurons
T5083 7703-7707 WDT denotes that
T5084 7708-7722 VBD denotes differentiated
T5085 7723-7730 IN denotes without
T5086 7731-7733 NN denotes Rb
T5087 7733-7734 . denotes .
T5088 7734-7882 sentence denotes E2f3 is also present in a specific subset of other CNS neurons, implying that this may be a general mechanism by which Rb facilitates neurogenesis.
T5089 7735-7739 NN denotes E2f3
T5090 7740-7742 VBZ denotes is
T5091 7743-7747 RB denotes also
T5092 7748-7755 JJ denotes present
T5093 7756-7758 IN denotes in
T5094 7759-7760 DT denotes a
T5095 7770-7776 NN denotes subset
T5096 7761-7769 JJ denotes specific
T5097 7777-7779 IN denotes of
T5098 7780-7785 JJ denotes other
T5099 7790-7797 NNS denotes neurons
T5100 7786-7789 NN denotes CNS
T5101 7797-7799 , denotes ,
T5102 7799-7807 VBG denotes implying
T5103 7808-7812 IN denotes that
T5104 7822-7824 VB denotes be
T5105 7813-7817 DT denotes this
T5106 7818-7821 MD denotes may
T5107 7825-7826 DT denotes a
T5108 7835-7844 NN denotes mechanism
T5109 7827-7834 JJ denotes general
T5110 7845-7847 IN denotes by
T5111 7857-7868 VBZ denotes facilitates
T5112 7848-7853 WDT denotes which
T5113 7854-7856 NN denotes Rb
T5114 7869-7881 NN denotes neurogenesis
T5115 7881-7882 . denotes .
T5116 7882-8003 sentence denotes To define the mechanism in even more detail, we determined which E2f3 isoform Rb targets to control SAC differentiation.
T5117 7883-7885 TO denotes To
T5118 7886-7892 VB denotes define
T5119 7931-7941 VBD denotes determined
T5120 7893-7896 DT denotes the
T5121 7897-7906 NN denotes mechanism
T5122 7907-7909 IN denotes in
T5123 7910-7914 RB denotes even
T5124 7920-7926 NN denotes detail
T5125 7915-7919 JJR denotes more
T5126 7926-7928 , denotes ,
T5127 7928-7930 PRP denotes we
T5128 7942-7947 WDT denotes which
T5129 7953-7960 NN denotes isoform
T5130 7948-7952 NN denotes E2f3
T5131 7964-7971 VBZ denotes targets
T5132 7961-7963 NN denotes Rb
T5133 7972-7974 TO denotes to
T5134 7975-7982 VB denotes control
T5135 7983-7986 NN denotes SAC
T5136 7987-8002 NN denotes differentiation
T5137 8002-8003 . denotes .
T5138 8003-8148 sentence denotes E2f3b mediates Rb function in quiescent fibroblasts [19], yet no prior studies to our knowledge have dissected E2f3a or E2f3b functions in vivo.
T5139 8004-8009 NN denotes E2f3b
T5140 8010-8018 VBZ denotes mediates
T5141 8019-8021 NN denotes Rb
T5142 8022-8030 NN denotes function
T5143 8031-8033 IN denotes in
T5144 8034-8043 JJ denotes quiescent
T5145 8044-8055 NNS denotes fibroblasts
T5146 8056-8057 -LRB- denotes [
T5147 8057-8059 CD denotes 19
T5148 8059-8060 -RRB- denotes ]
T5149 8060-8062 , denotes ,
T5150 8062-8065 CC denotes yet
T5151 8066-8068 DT denotes no
T5152 8075-8082 NNS denotes studies
T5153 8069-8074 JJ denotes prior
T5154 8105-8114 VBN denotes dissected
T5155 8083-8085 IN denotes to
T5156 8086-8089 PRP$ denotes our
T5157 8090-8099 NN denotes knowledge
T5158 8100-8104 VBP denotes have
T5159 8115-8120 NN denotes E2f3a
T5160 8130-8139 NNS denotes functions
T5161 8121-8123 CC denotes or
T5162 8124-8129 NN denotes E2f3b
T5163 8140-8142 FW denotes in
T5164 8143-8147 FW denotes vivo
T5165 8147-8148 . denotes .
T5166 8148-8243 sentence denotes Using an isoform-specific null mouse we show that Rb drives SAC differentiation through E2f3a.
T5167 8149-8154 VBG denotes Using
T5168 8189-8193 VBP denotes show
T5169 8155-8157 DT denotes an
T5170 8180-8185 NN denotes mouse
T5171 8158-8165 NN denotes isoform
T5172 8166-8174 JJ denotes specific
T5173 8165-8166 HYPH denotes -
T5174 8175-8179 JJ denotes null
T5175 8186-8188 PRP denotes we
T5176 8194-8198 IN denotes that
T5177 8202-8208 VBZ denotes drives
T5178 8199-8201 NN denotes Rb
T5179 8209-8212 NN denotes SAC
T5180 8213-8228 NN denotes differentiation
T5181 8229-8236 IN denotes through
T5182 8237-8242 NN denotes E2f3a
T5183 8242-8243 . denotes .
T5184 8243-8460 sentence denotes Thus, independent of E2f1-mediated effects on division and death, Rb does regulate neuronal differentiation, but only in specific neurons and, unexpectedly, through E2f3a, not tissue-specific differentiation factors.
T5185 8244-8248 RB denotes Thus
T5186 8318-8326 VB denotes regulate
T5187 8248-8250 , denotes ,
T5188 8250-8261 JJ denotes independent
T5189 8262-8264 IN denotes of
T5190 8265-8269 NN denotes E2f1
T5191 8270-8278 VBN denotes mediated
T5192 8269-8270 HYPH denotes -
T5193 8279-8286 NNS denotes effects
T5194 8287-8289 IN denotes on
T5195 8290-8298 NN denotes division
T5196 8299-8302 CC denotes and
T5197 8303-8308 NN denotes death
T5198 8308-8310 , denotes ,
T5199 8310-8312 NN denotes Rb
T5200 8313-8317 VBZ denotes does
T5201 8327-8335 JJ denotes neuronal
T5202 8336-8351 NN denotes differentiation
T5203 8351-8353 , denotes ,
T5204 8353-8356 IN denotes but
T5205 8362-8364 IN denotes in
T5206 8357-8361 RB denotes only
T5207 8365-8373 JJ denotes specific
T5208 8374-8381 NNS denotes neurons
T5209 8382-8385 CC denotes and
T5210 8385-8387 , denotes ,
T5211 8387-8399 RB denotes unexpectedly
T5212 8401-8408 IN denotes through
T5213 8399-8401 , denotes ,
T5214 8409-8414 NN denotes E2f3a
T5215 8414-8416 , denotes ,
T5216 8416-8419 CC denotes not
T5217 8420-8426 NN denotes tissue
T5218 8427-8435 JJ denotes specific
T5219 8426-8427 HYPH denotes -
T5220 8452-8459 NNS denotes factors
T5221 8436-8451 NN denotes differentiation
T5222 8459-8460 . denotes .
T33426 1077-1081 NN denotes E2f1
T33427 1105-1109 NN denotes Loss
T33428 1081-1083 , denotes ,
T33429 1083-1086 CC denotes but
T33430 1087-1090 RB denotes Not
T33431 1091-1095 NN denotes E2f2
T33432 1096-1098 CC denotes or
T33433 1099-1103 NN denotes E2f3
T33434 1103-1105 , denotes ,
T33435 1110-1117 VBZ denotes Rescues
T33436 1118-1125 JJ denotes Ectopic
T33437 1126-1134 NN denotes Division
T33438 1135-1138 CC denotes and
T33439 1139-1143 NN denotes Cell
T33440 1144-1149 NN denotes Death
T33441 1150-1152 IN denotes in
T33442 1153-1156 DT denotes the
T33443 1163-1169 NN denotes Retina
T33444 1157-1159 NN denotes Rb
T33445 1160-1162 NN denotes KO
T33446 1169-1194 sentence denotes (A) Retinal development.
T33447 1170-1171 -LRB- denotes (
T33448 1171-1172 LS denotes A
T33449 1182-1193 NN denotes development
T33450 1172-1173 -RRB- denotes )
T33451 1174-1181 JJ denotes Retinal
T33452 1193-1194 . denotes .
T33453 1194-1268 sentence denotes At E11 the retina is a NBL of dividing RPCs (white circle, green nuclei).
T33454 1195-1197 IN denotes At
T33455 1213-1215 VBZ denotes is
T33456 1198-1201 NN denotes E11
T33457 1202-1205 DT denotes the
T33458 1206-1212 NN denotes retina
T33459 1216-1217 DT denotes a
T33460 1218-1221 NN denotes NBL
T33461 1222-1224 IN denotes of
T33462 1225-1233 VBG denotes dividing
T33463 1234-1238 NNS denotes RPCs
T33464 1239-1240 -LRB- denotes (
T33465 1260-1266 NNS denotes nuclei
T33466 1240-1245 JJ denotes white
T33467 1246-1252 NN denotes circle
T33468 1252-1254 , denotes ,
T33469 1254-1259 JJ denotes green
T33470 1266-1267 -RRB- denotes )
T33471 1267-1268 . denotes .
T33472 1268-1351 sentence denotes RPC cell bodies oscillate along processes as they progress through the cell cycle.
T33473 1269-1272 NN denotes RPC
T33474 1278-1284 NNS denotes bodies
T33475 1273-1277 NN denotes cell
T33476 1285-1294 VBP denotes oscillate
T33477 1295-1300 IN denotes along
T33478 1301-1310 NNS denotes processes
T33479 1311-1313 IN denotes as
T33480 1319-1327 VBP denotes progress
T33481 1314-1318 PRP denotes they
T33482 1328-1335 IN denotes through
T33483 1336-1339 DT denotes the
T33484 1345-1350 NN denotes cycle
T33485 1340-1344 NN denotes cell
T33486 1350-1351 . denotes .
T33487 1351-1479 sentence denotes By P0 the NBL contains both RPCs and post-mitotic RTCs (coloured circles, red nuclei) and is separated from the GCL by the IPL.
T33488 1352-1354 IN denotes By
T33489 1366-1374 VBZ denotes contains
T33490 1355-1357 NN denotes P0
T33491 1358-1361 DT denotes the
T33492 1362-1365 NN denotes NBL
T33493 1375-1379 CC denotes both
T33494 1380-1384 NNS denotes RPCs
T33495 1385-1388 CC denotes and
T33496 1389-1401 JJ denotes post-mitotic
T33497 1402-1406 NNS denotes RTCs
T33498 1407-1408 -LRB- denotes (
T33499 1430-1436 NNS denotes nuclei
T33500 1408-1416 VBN denotes coloured
T33501 1417-1424 NNS denotes circles
T33502 1424-1426 , denotes ,
T33503 1426-1429 JJ denotes red
T33504 1436-1437 -RRB- denotes )
T33505 1438-1441 CC denotes and
T33506 1442-1444 VBZ denotes is
T33507 1445-1454 VBN denotes separated
T33508 1455-1459 IN denotes from
T33509 1460-1463 DT denotes the
T33510 1464-1467 NN denotes GCL
T33511 1468-1470 IN denotes by
T33512 1471-1474 DT denotes the
T33513 1475-1478 NN denotes IPL
T33514 1478-1479 . denotes .
T33515 1479-1717 sentence denotes By P8 there are no RPCs, fewer RTCs, an OPL, and more differentiated rods (r) and cones (c) in the ONL; horizontal (h), bipolar (b), Müller (m), and amacrine (a) cells in the INL; and ganglion (g) and displaced amacrine cells in the GCL.
T33516 1480-1482 IN denotes By
T33517 1492-1495 VBP denotes are
T33518 1483-1485 NN denotes P8
T33519 1486-1491 EX denotes there
T33520 1496-1498 DT denotes no
T33521 1499-1503 NNS denotes RPCs
T33522 1503-1505 , denotes ,
T33523 1505-1510 JJR denotes fewer
T33524 1511-1515 NNS denotes RTCs
T33525 1515-1517 , denotes ,
T33526 1517-1519 DT denotes an
T33527 1520-1523 NN denotes OPL
T33528 1523-1525 , denotes ,
T33529 1525-1528 CC denotes and
T33530 1529-1533 JJR denotes more
T33531 1549-1553 NNS denotes rods
T33532 1534-1548 VBN denotes differentiated
T33533 1554-1555 -LRB- denotes (
T33534 1555-1556 NN denotes r
T33535 1556-1557 -RRB- denotes )
T33536 1558-1561 CC denotes and
T33537 1562-1567 NNS denotes cones
T33538 1568-1569 -LRB- denotes (
T33539 1569-1570 NN denotes c
T33540 1570-1571 -RRB- denotes )
T33541 1572-1574 IN denotes in
T33542 1575-1578 DT denotes the
T33543 1579-1582 NN denotes ONL
T33544 1582-1583 : denotes ;
T33545 1584-1594 JJ denotes horizontal
T33546 1642-1647 NNS denotes cells
T33547 1595-1596 -LRB- denotes (
T33548 1596-1597 NN denotes h
T33549 1597-1598 -RRB- denotes )
T33550 1598-1600 , denotes ,
T33551 1600-1607 JJ denotes bipolar
T33552 1608-1609 -LRB- denotes (
T33553 1609-1610 NN denotes b
T33554 1610-1611 -RRB- denotes )
T33555 1611-1613 , denotes ,
T33556 1613-1619 NN denotes Müller
T33557 1620-1621 -LRB- denotes (
T33558 1621-1622 NN denotes m
T33559 1622-1623 -RRB- denotes )
T33560 1623-1625 , denotes ,
T33561 1625-1628 CC denotes and
T33562 1629-1637 JJ denotes amacrine
T33563 1638-1639 -LRB- denotes (
T33564 1639-1640 JJ denotes a
T33565 1640-1641 -RRB- denotes )
T33566 1648-1650 IN denotes in
T33567 1651-1654 DT denotes the
T33568 1655-1658 NN denotes INL
T33569 1658-1659 : denotes ;
T33570 1660-1663 CC denotes and
T33571 1664-1672 NN denotes ganglion
T33572 1673-1674 -LRB- denotes (
T33573 1674-1675 NN denotes g
T33574 1675-1676 -RRB- denotes )
T33575 1677-1680 CC denotes and
T33576 1681-1690 VBN denotes displaced
T33577 1691-1699 JJ denotes amacrine
T33578 1700-1705 NNS denotes cells
T33579 1706-1708 IN denotes in
T33580 1709-1712 DT denotes the
T33581 1713-1716 NN denotes GCL
T33582 1716-1717 . denotes .
T33583 1717-1750 sentence denotes Development is complete by ~P18.
T33584 1718-1729 NN denotes Development
T33585 1730-1732 VBZ denotes is
T33586 1733-1741 JJ denotes complete
T33587 1742-1744 IN denotes by
T33588 1745-1746 SYM denotes ~
T33589 1746-1749 NN denotes P18
T33590 1749-1750 . denotes .
T33591 1750-1911 sentence denotes (B) Rb is thought to regulate cell cycle and apoptosis by repressing E2fs, but to promote differentiation by potentiating tissue-specific transcription factors.
T33592 1751-1752 -LRB- denotes (
T33593 1752-1753 LS denotes B
T33594 1761-1768 VBN denotes thought
T33595 1753-1754 -RRB- denotes )
T33596 1755-1757 NN denotes Rb
T33597 1758-1760 VBZ denotes is
T33598 1769-1771 TO denotes to
T33599 1772-1780 VB denotes regulate
T33600 1781-1785 NN denotes cell
T33601 1786-1791 NN denotes cycle
T33602 1792-1795 CC denotes and
T33603 1796-1805 NN denotes apoptosis
T33604 1806-1808 IN denotes by
T33605 1809-1819 VBG denotes repressing
T33606 1820-1824 NNS denotes E2fs
T33607 1824-1826 , denotes ,
T33608 1826-1829 CC denotes but
T33609 1830-1832 TO denotes to
T33610 1833-1840 VB denotes promote
T33611 1841-1856 NN denotes differentiation
T33612 1857-1859 IN denotes by
T33613 1860-1872 VBG denotes potentiating
T33614 1873-1879 NN denotes tissue
T33615 1880-1888 JJ denotes specific
T33616 1879-1880 HYPH denotes -
T33617 1903-1910 NNS denotes factors
T33618 1889-1902 NN denotes transcription
T33619 1910-1911 . denotes .
T33620 1911-2090 sentence denotes However, Rb loss could also perturb differentiation through the indirect effects of abnormal division or death, and/or through direct regulation of differentiation genes by E2fs.
T33621 1912-1919 RB denotes However
T33622 1940-1947 VB denotes perturb
T33623 1919-1921 , denotes ,
T33624 1921-1923 NN denotes Rb
T33625 1924-1928 NN denotes loss
T33626 1929-1934 MD denotes could
T33627 1935-1939 RB denotes also
T33628 1948-1963 NN denotes differentiation
T33629 1964-1971 IN denotes through
T33630 1972-1975 DT denotes the
T33631 1985-1992 NNS denotes effects
T33632 1976-1984 JJ denotes indirect
T33633 1993-1995 IN denotes of
T33634 1996-2004 JJ denotes abnormal
T33635 2005-2013 NN denotes division
T33636 2014-2016 CC denotes or
T33637 2017-2022 NN denotes death
T33638 2022-2024 , denotes ,
T33639 2024-2027 CC denotes and
T33640 2027-2028 HYPH denotes /
T33641 2028-2030 CC denotes or
T33642 2031-2038 IN denotes through
T33643 2039-2045 JJ denotes direct
T33644 2046-2056 NN denotes regulation
T33645 2057-2059 IN denotes of
T33646 2060-2075 NN denotes differentiation
T33647 2076-2081 NNS denotes genes
T33648 2082-2084 IN denotes by
T33649 2085-2089 NNS denotes E2fs
T33650 2089-2090 . denotes .
T33651 2090-2266 sentence denotes (C and D) Horizontal retinal sections of the indicated genotypes and ages were stained for nuclei (DAPI, blue), and (C) S-phase (anti-BrdU, red) or (D) apoptosis (TUNEL, red).
T33652 2091-2092 -LRB- denotes (
T33653 2092-2093 LS denotes C
T33654 2170-2177 VBN denotes stained
T33655 2094-2097 CC denotes and
T33656 2098-2099 LS denotes D
T33657 2099-2100 -RRB- denotes )
T33658 2101-2111 JJ denotes Horizontal
T33659 2120-2128 NNS denotes sections
T33660 2112-2119 JJ denotes retinal
T33661 2129-2131 IN denotes of
T33662 2132-2135 DT denotes the
T33663 2146-2155 NNS denotes genotypes
T33664 2136-2145 VBN denotes indicated
T33665 2156-2159 CC denotes and
T33666 2160-2164 NNS denotes ages
T33667 2165-2169 VBD denotes were
T33668 2178-2181 IN denotes for
T33669 2182-2188 NNS denotes nuclei
T33670 2189-2190 -LRB- denotes (
T33671 2196-2200 JJ denotes blue
T33672 2190-2194 NN denotes DAPI
T33673 2194-2196 , denotes ,
T33674 2200-2201 -RRB- denotes )
T33675 2201-2203 , denotes ,
T33676 2203-2206 CC denotes and
T33677 2207-2208 -LRB- denotes (
T33678 2208-2209 NN denotes C
T33679 2213-2218 NN denotes phase
T33680 2209-2210 -RRB- denotes )
T33681 2211-2212 NN denotes S
T33682 2212-2213 HYPH denotes -
T33683 2219-2220 -LRB- denotes (
T33684 2231-2234 JJ denotes red
T33685 2220-2229 JJ denotes anti-BrdU
T33686 2229-2231 , denotes ,
T33687 2234-2235 -RRB- denotes )
T33688 2236-2238 CC denotes or
T33689 2239-2240 -LRB- denotes (
T33690 2240-2241 NN denotes D
T33691 2243-2252 NN denotes apoptosis
T33692 2241-2242 -RRB- denotes )
T33693 2253-2254 -LRB- denotes (
T33694 2261-2264 JJ denotes red
T33695 2254-2259 NN denotes TUNEL
T33696 2259-2261 , denotes ,
T33697 2264-2265 -RRB- denotes )
T33698 2265-2266 . denotes .
T33699 2266-2288 sentence denotes Scale bars are 50 μm.
T33700 2267-2272 NN denotes Scale
T33701 2273-2277 NNS denotes bars
T33702 2278-2281 VBP denotes are
T33703 2282-2284 CD denotes 50
T33704 2285-2287 NN denotes μm
T33705 2287-2288 . denotes .
T33706 2288-2399 sentence denotes (E–G) Quantification of (E) all BrdU+ cells, (F) ectopic BrdU+ cells in GCL at P0, and (G) total TUNEL+ cells.
T33707 2289-2290 -LRB- denotes (
T33708 2290-2291 LS denotes E
T33709 2295-2309 NN denotes Quantification
T33710 2291-2292 SYM denotes –
T33711 2292-2293 LS denotes G
T33712 2293-2294 -RRB- denotes )
T33713 2310-2312 IN denotes of
T33714 2313-2314 -LRB- denotes (
T33715 2314-2315 NN denotes E
T33716 2327-2332 NNS denotes cells
T33717 2315-2316 -RRB- denotes )
T33718 2317-2320 DT denotes all
T33719 2321-2325 NN denotes BrdU
T33720 2325-2326 SYM denotes +
T33721 2332-2334 , denotes ,
T33722 2334-2335 -LRB- denotes (
T33723 2335-2336 NN denotes F
T33724 2352-2357 NNS denotes cells
T33725 2336-2337 -RRB- denotes )
T33726 2338-2345 JJ denotes ectopic
T33727 2346-2350 NN denotes BrdU
T33728 2350-2351 SYM denotes +
T33729 2358-2360 IN denotes in
T33730 2361-2364 NN denotes GCL
T33731 2365-2367 IN denotes at
T33732 2368-2370 NN denotes P0
T33733 2370-2372 , denotes ,
T33734 2372-2375 CC denotes and
T33735 2376-2377 -LRB- denotes (
T33736 2377-2378 NN denotes G
T33737 2393-2398 NNS denotes cells
T33738 2378-2379 -RRB- denotes )
T33739 2380-2385 JJ denotes total
T33740 2386-2391 NN denotes TUNEL
T33741 2391-2392 SYM denotes +
T33742 2398-2399 . denotes .
T33743 2399-2500 sentence denotes (H) Real-time RT-PCR analysis of E2fs and E2f target genes in P8 retinas of the indicated genotypes.
T33744 2400-2401 -LRB- denotes (
T33745 2401-2402 LS denotes H
T33746 2421-2429 NN denotes analysis
T33747 2402-2403 -RRB- denotes )
T33748 2404-2408 JJ denotes Real
T33749 2409-2413 NN denotes time
T33750 2408-2409 HYPH denotes -
T33751 2417-2420 NN denotes PCR
T33752 2414-2416 NN denotes RT
T33753 2416-2417 HYPH denotes -
T33754 2430-2432 IN denotes of
T33755 2433-2437 NNS denotes E2fs
T33756 2438-2441 CC denotes and
T33757 2442-2445 NN denotes E2f
T33758 2453-2458 NNS denotes genes
T33759 2446-2452 NN denotes target
T33760 2459-2461 IN denotes in
T33761 2462-2464 NN denotes P8
T33762 2465-2472 NNS denotes retinas
T33763 2473-2475 IN denotes of
T33764 2476-2479 DT denotes the
T33765 2490-2499 NNS denotes genotypes
T33766 2480-2489 VBN denotes indicated
T33767 2499-2500 . denotes .
T33768 2500-2734 sentence denotes Error bars represent SD of measurements from three animals, and asterisks indicate a significant difference between the WT and indicated genotypes (*, p <0.05; **; p <0.01; ANOVA and Tukey HSD test for [E–G] and Fisher test for [H]).
T33769 2501-2506 NN denotes Error
T33770 2507-2511 NNS denotes bars
T33771 2512-2521 VBP denotes represent
T33772 2522-2524 NN denotes SD
T33773 2525-2527 IN denotes of
T33774 2528-2540 NNS denotes measurements
T33775 2541-2545 IN denotes from
T33776 2546-2551 CD denotes three
T33777 2552-2559 NNS denotes animals
T33778 2559-2561 , denotes ,
T33779 2561-2564 CC denotes and
T33780 2565-2574 NNS denotes asterisks
T33781 2575-2583 VBP denotes indicate
T33782 2584-2585 DT denotes a
T33783 2598-2608 NN denotes difference
T33784 2586-2597 JJ denotes significant
T33785 2609-2616 IN denotes between
T33786 2617-2620 DT denotes the
T33787 2638-2647 NNS denotes genotypes
T33788 2621-2623 NN denotes WT
T33789 2624-2627 CC denotes and
T33790 2628-2637 VBN denotes indicated
T33791 2648-2649 -LRB- denotes (
T33792 2694-2698 NN denotes test
T33793 2649-2650 SYM denotes *
T33794 2655-2659 CD denotes 0.05
T33795 2650-2652 , denotes ,
T33796 2652-2653 NN denotes p
T33797 2654-2655 SYM denotes <
T33798 2659-2660 : denotes ;
T33799 2661-2663 SYM denotes **
T33800 2668-2672 CD denotes 0.01
T33801 2663-2664 : denotes ;
T33802 2665-2666 NN denotes p
T33803 2667-2668 SYM denotes <
T33804 2672-2673 : denotes ;
T33805 2674-2679 NN denotes ANOVA
T33806 2680-2683 CC denotes and
T33807 2684-2689 NNP denotes Tukey
T33808 2690-2693 NN denotes HSD
T33809 2699-2702 IN denotes for
T33810 2703-2704 -LRB- denotes [
T33811 2704-2705 NN denotes E
T33812 2705-2706 SYM denotes –
T33813 2706-2707 NN denotes G
T33814 2707-2708 -RRB- denotes ]
T33815 2709-2712 CC denotes and
T33816 2713-2719 NNP denotes Fisher
T33817 2720-2724 NN denotes test
T33818 2725-2728 IN denotes for
T33819 2729-2730 -LRB- denotes [
T33820 2730-2731 NN denotes H
T33821 2731-2732 -RRB- denotes ]
T33822 2732-2733 -RRB- denotes )
T33823 2733-2734 . denotes .
T4015 793-795 , denotes ,
T4016 802-804 IN denotes in
T4017 805-808 DT denotes the
T4018 823-828 NN denotes layer
T4019 809-814 JJ denotes inner
T4020 815-822 JJ denotes nuclear
T4021 829-830 -LRB- denotes (
T4022 830-833 NN denotes INL
T4023 833-834 -RRB- denotes )
T4024 834-835 : denotes ;
T4025 836-839 CC denotes and
T4026 840-848 NN denotes ganglion
T4027 878-882 VBP denotes form
T4028 849-852 CC denotes and
T4029 853-862 VBN denotes displaced
T4030 863-871 JJ denotes amacrine
T4031 872-877 NNS denotes cells
T4032 883-886 DT denotes the
T4033 901-906 NN denotes layer
T4034 887-895 NN denotes ganglion
T4035 896-900 NN denotes cell
T4036 907-908 -LRB- denotes (
T4037 908-911 NN denotes GCL
T4038 911-912 -RRB- denotes )
T4039 913-914 -LRB- denotes (
T4040 921-923 NN denotes 1A
T4041 914-920 NN denotes Figure
T4042 923-924 -RRB- denotes )
T4043 924-925 . denotes .
T4044 925-1066 sentence denotes The outer plexiform layer (OPL) and inner plexiform layer (IPL) house synaptic connections separating the ONL/INL and INL/GCL, respectively.
T4045 926-929 DT denotes The
T4046 946-951 NN denotes layer
T4047 930-935 JJ denotes outer
T4048 936-945 NN denotes plexiform
T4049 990-995 VBP denotes house
T4050 952-953 -LRB- denotes (
T4051 953-956 NN denotes OPL
T4052 956-957 -RRB- denotes )
T4053 958-961 CC denotes and
T4054 962-967 JJ denotes inner
T4055 978-983 NN denotes layer
T4056 968-977 NN denotes plexiform
T4075 2735-2739 sentence denotes The
T4076 2735-2736 NNS denotes T
T4077 2736-2738 DT denotes he
T4078 2739-2754 sentence denotes retinoblastoma
T4079 2739-2741 EX denotes re
T4080 2741-2743 VBN denotes ti
T4081 2743-2744 CC denotes n
T4082 2744-2745 NNS denotes o
T4083 2748-2749 NNS denotes s
T4084 2745-2748 JJ denotes bla
T4085 2749-2750 DT denotes t
T4086 2750-2751 NN denotes o
T4087 2751-2753 JJ denotes ma
T4088 2754-2755 sentence denotes p
T4089 2754-2755 NN denotes p
T4090 2755-2762 sentence denotes rotein
T4091 2755-2756 VB denotes r
T4092 2756-2758 NN denotes ot
T4093 2758-2761 VBG denotes ein
T4094 2762-2763 sentence denotes (
T4095 2762-2763 -LRB- denotes (
T4096 2763-2764 sentence denotes R
T4097 2763-2764 JJ denotes R
T4098 2764-2766 sentence denotes b)
T4099 2764-2765 NNS denotes b
T4100 2765-2766 -RRB- denotes )
T4101 2766-2836 sentence denotes is critical for cell cycle exit during retinal transition cell birth.
T4102 2767-2769 NN denotes is
T4103 2770-2778 JJ denotes critical
T4104 2779-2782 IN denotes for
T4105 2783-2787 NN denotes cell
T4106 2788-2793 NN denotes cycle
T4107 2794-2798 NN denotes exit
T4108 2799-2805 IN denotes during
T4109 2806-2813 JJ denotes retinal
T4110 2825-2829 NN denotes cell
T4111 2814-2824 NN denotes transition
T4112 2830-2835 NN denotes birth
T4113 2835-2836 . denotes .
T4114 2836-2966 sentence denotes Rb knockout (KO) RTCs continue to proliferate inappropriately and some (rod, ganglion, and bipolar cells) die by apoptosis [2,3].
T4115 2837-2839 NN denotes Rb
T4116 2840-2848 NN denotes knockout
T4117 2854-2858 NNS denotes RTCs
T4118 2849-2850 -LRB- denotes (
T4119 2850-2852 NN denotes KO
T4120 2852-2853 -RRB- denotes )
T4121 2859-2867 VBP denotes continue
T4122 2868-2870 TO denotes to
T4123 2871-2882 VB denotes proliferate
T4124 2883-2898 RB denotes inappropriately
T4125 2899-2902 CC denotes and
T4126 2903-2907 DT denotes some
T4127 2943-2946 VBP denotes die
T4128 2908-2909 -LRB- denotes (
T4129 2909-2912 NN denotes rod
T4130 2936-2941 NNS denotes cells
T4131 2912-2914 , denotes ,
T4132 2914-2922 NN denotes ganglion
T4133 2922-2924 , denotes ,
T4134 2924-2927 CC denotes and
T4135 2928-2935 JJ denotes bipolar
T4136 2941-2942 -RRB- denotes )
T4137 2947-2949 IN denotes by
T4138 2950-2959 NN denotes apoptosis
T4139 2960-2961 -LRB- denotes [
T4140 2963-2964 CD denotes 3
T4141 2961-2962 CD denotes 2
T4142 2962-2963 , denotes ,
T4144 2965-2966 . denotes .
T4582 5090-5093 CC denotes and
R285 T3864 T3865 det The,simplicity
R289 T3865 T3866 nsubj simplicity,makes
R290 T3867 T3865 prep of,simplicity
R291 T3868 T3869 det the,retina
R292 T3869 T3867 pobj retina,of
R293 T3870 T3871 nsubj it,tissue
R294 T3871 T3866 ccomp tissue,makes
R295 T3872 T3871 det an,tissue
R296 T3873 T3871 amod ideal,tissue
R297 T3874 T3875 aux to,study
R298 T3875 T3871 advcl study,tissue
R299 T3876 T3875 dobj neurogenesis,study
R300 T3877 T3866 punct .,makes
R301 T3879 T3880 poss Its,development
R302 T3880 T3881 nsubj development,proceeds
R303 T3882 T3881 prep through,proceeds
R304 T3883 T3884 nummod three,steps
R305 T3884 T3882 pobj steps,through
R306 T3885 T3884 amod overlapping,steps
R307 T3886 T3881 advcl starting,proceeds
R308 T3887 T3886 prep with,starting
R309 T3888 T3889 amod retinal,cell
R310 T3889 T3891 nmod cell,proliferation
R311 T3890 T3889 nmod progenitor,cell
R312 T3891 T3887 pobj proliferation,with
R313 T3892 T3889 punct (,cell
R314 T3893 T3889 appos RPC,cell
R315 T3894 T3891 punct ),proliferation
R316 T3895 T3891 punct ", ",proliferation
R317 T3896 T3891 acl followed,proliferation
R318 T3897 T3896 agent by,followed
R319 T3898 T3897 pobj birth,by
R320 T3899 T3898 prep of,birth
R321 T3900 T3901 amod post-mitotic,cells
R322 T3909 T3908 prep to,referred
R323 T3910 T3908 prep as,referred
R324 T3911 T3910 pobj precursors,as
R325 T3912 T3886 punct ),starting
R326 T3913 T3886 punct ", ",starting
R327 T3901 T3899 pobj cells,of
R328 T3914 T3886 cc and,starting
R329 T3915 T3886 conj ending,starting
R330 T3916 T3915 prep with,ending
R331 T3917 T3918 amod terminal,differentiation
R332 T3902 T3901 amod retinal,cells
R333 T3918 T3916 pobj differentiation,with
R334 T3919 T3918 prep of,differentiation
R335 T3920 T3921 nummod seven,types
R336 T3903 T3901 compound transition,cells
R337 T3921 T3919 pobj types,of
R338 T3922 T3921 amod major,types
R339 T3923 T3921 compound cell,types
R340 T3904 T3901 punct (,cells
R341 T3924 T3925 punct (,1A
R342 T3925 T3881 parataxis 1A,proceeds
R343 T3926 T3925 compound Figure,1A
R344 T3905 T3901 appos RTCs,cells
R345 T3927 T3925 punct ),1A
R346 T3928 T3929 punct [,1
R347 T3906 T3901 punct ", ",cells
R348 T3929 T3881 parataxis 1,proceeds
R349 T3930 T3929 punct ],1
R350 T3931 T3881 punct .,proceeds
R351 T3907 T3908 advmod also,referred
R352 T3933 T3934 nsubj RPCs,are
R353 T3908 T3901 acl referred,cells
R354 T3935 T3934 acomp multipotent,are
R355 T3936 T3934 cc and,are
R356 T4015 T4006 punct ", ",reside
R357 T3937 T3934 conj exit,are
R358 T3938 T3939 det the,cycle
R359 T3939 T3937 dobj cycle,exit
R360 T4016 T4006 prep in,reside
R361 T3940 T3939 compound cell,cycle
R362 T3941 T3942 aux to,generate
R363 T3942 T3937 advcl generate,exit
R364 T4017 T4018 det the,layer
R365 T3943 T3944 amod different,RTCs
R366 T4018 T4016 pobj layer,in
R367 T3944 T3942 dobj RTCs,generate
R368 T3945 T3942 prep at,generate
R369 T4019 T4018 amod inner,layer
R370 T3946 T3947 amod specific,periods
R371 T3947 T3945 pobj periods,at
R372 T3948 T3947 compound time,periods
R373 T4020 T4018 amod nuclear,layer
R374 T3949 T3947 prep in,periods
R375 T3950 T3949 pobj development,in
R376 T3951 T3952 punct [,1
R377 T3952 T3942 parataxis 1,generate
R378 T3953 T3952 punct ],1
R379 T3954 T3934 punct .,are
R380 T4021 T4018 punct (,layer
R381 T3956 T3957 det This,process
R382 T3957 T3958 nsubj process,requires
R383 T4022 T4018 appos INL,layer
R384 T3959 T3957 prep of,process
R385 T3960 T3961 nmod RTC,birth
R386 T3961 T3959 pobj birth,of
R387 T4023 T4006 punct ),reside
R388 T3962 T3961 punct “,birth
R389 T3963 T3958 punct ”,requires
R390 T3964 T3958 dobj coupling,requires
R391 T4024 T4006 punct ;,reside
R392 T3965 T3964 prep of,coupling
R393 T3966 T3965 pobj differentiation,of
R394 T3967 T3966 cc and,differentiation
R395 T4025 T4006 cc and,reside
R396 T3968 T3969 compound cell,cycle
R397 T3969 T3970 compound cycle,exit
R398 T3970 T3966 conj exit,differentiation
R399 T4026 T4027 nsubj ganglion,form
R400 T3971 T3958 punct .,requires
R402 T3973 T3974 mark Once,born
R403 T4028 T4026 cc and,ganglion
R404 T3974 T3975 advcl born,migrate
R405 T3976 T3975 punct ", ",migrate
R406 T4029 T4030 amod displaced,amacrine
R407 T3977 T3978 amod post-mitotic,RTCs
R408 T3978 T3975 nsubj RTCs,migrate
R409 T3979 T3975 cc and,migrate
R410 T4030 T4031 nmod amacrine,cells
R411 T3980 T3975 conj form,migrate
R412 T3981 T3982 amod different,layers
R413 T3982 T3980 dobj layers,form
R415 T3983 T3982 amod retinal,layers
R416 T3984 T3975 punct .,migrate
R417 T3986 T3987 nsubj Rods,make
R419 T3988 T3986 cc and,Rods
R421 T3989 T3986 conj cones,Rods
R422 T3990 T3987 prt up,make
R423 T3991 T3992 det the,layer
R424 T3992 T3987 dobj layer,make
R426 T3993 T3992 amod outer,layer
R427 T3994 T3992 amod nuclear,layer
R428 T3995 T3992 punct (,layer
R429 T3996 T3992 appos ONL,layer
R430 T3997 T3987 punct ),make
R431 T3998 T3987 punct ;,make
R432 T3999 T4000 amod horizontal,cells
R434 T4000 T4006 nsubj cells,reside
R435 T4001 T3999 punct ", ",horizontal
R436 T4002 T3999 conj bipolar,horizontal
R438 T4003 T4002 punct ", ",bipolar
R439 T4004 T4002 cc and,bipolar
R440 T4005 T4002 conj amacrine,bipolar
R442 T4006 T3987 conj reside,make
R443 T4007 T4000 punct ", ",cells
R444 T4008 T4009 advmod as,as
R446 T4009 T4000 cc as,cells
R447 T4010 T4009 advmod well,as
R448 T4011 T4012 compound Müller,glia
R450 T4012 T4013 compound glia,bodies
R451 T4013 T4000 conj bodies,cells
R452 T4014 T4013 compound cell,bodies
R481 T4069 T4064 conj GCL,INL
R482 T4070 T4069 punct /,GCL
R485 T4071 T4049 punct ", ",house
R488 T4072 T4049 advmod respectively,house
R492 T4073 T4049 punct .,house
R503 T4122 T4123 aux to,proliferate
R504 T4123 T4121 xcomp proliferate,continue
R505 T4124 T4123 advmod inappropriately,proliferate
R506 T4162 T4156 parataxis 1B,factors
R507 T4125 T4121 cc and,continue
R508 T4126 T4127 nsubj some,die
R509 T4163 T4162 compound Figure,1B
R510 T4127 T4121 conj die,continue
R511 T4128 T4126 punct (,some
R512 T4129 T4130 nmod rod,cells
R513 T4164 T4162 punct ),1B
R514 T4130 T4126 appos cells,some
R515 T4131 T4129 punct ", ",rod
R516 T4132 T4129 conj ganglion,rod
R517 T4165 T4156 punct ", ",factors
R518 T4133 T4132 punct ", ",ganglion
R519 T4134 T4132 cc and,ganglion
R520 T4135 T4132 conj bipolar,ganglion
R521 T4166 T4167 advmod first,defined
R522 T4136 T4127 punct ),die
R523 T4137 T4127 prep by,die
R524 T4138 T4137 pobj apoptosis,by
R525 T4139 T4140 punct [,3
R526 T4167 T4156 acl defined,factors
R527 T4140 T4127 parataxis 3,die
R528 T4141 T4140 nummod 2,3
R529 T4142 T4140 punct ",",3
R530 T4168 T4167 prep as,defined
R531 T4143 T4140 punct ],3
R532 T4144 T4127 punct .,die
R533 T4146 T4147 nsubj Rb,controls
R534 T4169 T4170 compound transcription,factors
R535 T4148 T4149 det the,cycle
R536 T4149 T4147 dobj cycle,controls
R537 T4150 T4149 compound cell,cycle
R538 T4151 T4147 prep by,controls
R539 T4170 T4168 pobj factors,as
R540 T4152 T4151 pcomp binding,by
R541 T4153 T4152 cc and,binding
R542 T4154 T4152 conj inhibiting,binding
R543 T4171 T4172 dep that,bind
R544 T4155 T4156 compound E2f,factors
R545 T4156 T4154 dobj factors,inhibiting
R546 T4157 T4156 compound transcription,factors
R547 T4172 T4170 relcl bind,factors
R548 T4158 T4156 punct (,factors
R549 T4173 T4174 amod adenoviral,elements
R550 T4174 T4172 dobj elements,bind
R551 T4265 T4263 pobj extents,to
R552 T4175 T4176 npadvmod E2,regulatory
R553 T4266 T4256 prep in,rescued
R554 T4267 T4268 amod different,tissues
R555 T4268 T4266 pobj tissues,in
R556 T4176 T4174 amod regulatory,elements
R557 T4269 T4256 prep by,rescued
R558 T4270 T4269 pcomp knocking,by
R559 T4177 T4167 cc and,defined
R560 T4271 T4270 prt out,knocking
R561 T4272 T4270 dobj E2f1,knocking
R562 T4273 T4272 punct ", ",E2f1
R563 T4178 T4179 advmod subsequently,shown
R564 T4274 T4272 conj E2f2,E2f1
R565 T4179 T4167 conj shown,defined
R566 T4275 T4274 punct ", ",E2f2
R567 T4180 T4181 aux to,be
R568 T4276 T4274 cc or,E2f2
R569 T4277 T4274 conj E2f3,E2f2
R570 T4181 T4179 xcomp be,shown
R571 T4278 T4279 punct [,6
R572 T4279 T4270 parataxis 6,knocking
R573 T4182 T4183 amod critical,regulators
R574 T4280 T4281 punct –,9
R575 T4281 T4279 prep 9,6
R576 T4282 T4279 punct ],6
R577 T4283 T4256 punct ", ",rescued
R578 T4183 T4181 attr regulators,be
R579 T4284 T4256 cc but,rescued
R580 T4285 T4286 det which,member
R581 T4286 T4287 dep member,drive
R582 T4184 T4185 compound cell,cycle
R583 T4287 T4291 csubj drive,is
R584 T4288 T4286 punct (,member
R585 T4289 T4286 nmod s,member
R586 T4290 T4286 punct ),member
R587 T4291 T4256 conj is,rescued
R588 T4292 T4287 dobj division,drive
R589 T4185 T4183 compound cycle,regulators
R590 T4293 T4287 prep in,drive
R591 T4294 T4295 compound Rb,KO
R592 T4186 T4187 punct [,5
R593 T4295 T4296 compound KO,RTCs
R594 T4296 T4293 pobj RTCs,in
R595 T4297 T4291 acomp unknown,is
R596 T4298 T4291 punct .,is
R597 T4187 T4181 parataxis 5,be
R598 T4300 T4301 amod Other,members
R599 T4188 T4187 nummod 4,5
R600 T4301 T4302 nsubjpass members,known
R601 T4303 T4301 prep of,members
R602 T4189 T4187 punct ",",5
R603 T4304 T4305 det the,family
R604 T4305 T4303 pobj family,of
R605 T4190 T4187 punct ],5
R606 T4306 T4301 punct ", ",members
R607 T4307 T4308 amod such,as
R608 T4308 T4301 prep as,members
R609 T4191 T4147 punct .,controls
R610 T4309 T4308 pobj E2f4,as
R611 T4310 T4309 cc and,E2f4
R612 T4311 T4309 conj E2f5,E2f4
R613 T4193 T4194 nsubj E2fs,bind
R614 T4312 T4302 punct ", ",known
R615 T4313 T4302 auxpass are,known
R616 T4314 T4302 prep as,known
R617 T4315 T4316 punct “,E2fs
R618 T4316 T4314 pobj E2fs,as
R619 T4195 T4194 prep to,bind
R620 T4317 T4316 amod repressive,E2fs
R621 T4318 T4302 punct ”,known
R622 T4319 T4320 mark because,are
R623 T4320 T4302 advcl are,known
R624 T4196 T4195 pobj DNA,to
R625 T4321 T4320 nsubj they,are
R626 T4322 T4323 amod weak,activators
R627 T4197 T4194 prep as,bind
R628 T4323 T4320 attr activators,are
R629 T4324 T4320 cc and,are
R630 T4325 T4320 conj appear,are
R631 T4198 T4197 pobj heterodimers,as
R632 T4326 T4327 aux to,involved
R633 T4327 T4325 xcomp involved,appear
R634 T4328 T4327 auxpass be,involved
R635 T4329 T4327 advmod primarily,involved
R636 T4330 T4327 prep in,involved
R637 T4199 T4198 prep with,heterodimers
R638 T4331 T4332 compound gene,silencing
R639 T4332 T4330 pobj silencing,in
R640 T4333 T4327 prep in,involved
R641 T4200 T4199 pobj proteins,with
R642 T4334 T4335 amod quiescent,cells
R643 T4335 T4333 pobj cells,in
R644 T4201 T4200 prep of,proteins
R645 T4336 T4334 cc or,quiescent
R646 T4337 T4334 conj differentiated,quiescent
R647 T4202 T4203 det the,family
R648 T4338 T4302 punct .,known
R649 T4340 T4341 csubj Activating,promote
R650 T4203 T4201 pobj family,of
R651 T4342 T4340 dobj E2fs,Activating
R652 T4343 T4341 aux may,promote
R653 T4204 T4203 amod related,family
R654 T4344 T4341 advmod also,promote
R655 T4345 T4341 dobj apoptosis,promote
R656 T4205 T4203 compound Tfdp,family
R657 T4346 T4341 prep in,promote
R658 T4206 T4194 punct .,bind
R659 T4347 T4348 det the,retina
R660 T4348 T4346 pobj retina,in
R661 T4208 T4209 nsubj E2f1,are
R662 T4349 T4350 compound Rb,KO
R663 T4350 T4348 compound KO,retina
R664 T4351 T4352 punct (,1B
R665 T4352 T4341 parataxis 1B,promote
R666 T4210 T4208 punct ", ",E2f1
R667 T4353 T4352 compound Figure,1B
R668 T4354 T4352 punct ),1B
R669 T4355 T4341 punct .,promote
R670 T4211 T4208 conj E2f2,E2f1
R671 T4357 T4358 advmod Originally,considered
R672 T4212 T4211 punct ", ",E2f2
R673 T4359 T4358 punct ", ",considered
R674 T4360 T4358 nsubjpass E2f1,considered
R675 T4213 T4211 cc and,E2f2
R676 T4361 T4358 auxpass was,considered
R677 T4362 T4363 det the,member
R678 T4363 T4358 oprd member,considered
R679 T4214 T4211 conj E2f3a,E2f2
R680 T4364 T4363 amod primary,member
R681 T4365 T4363 amod pro-apoptotic,member
R682 T4366 T4363 prep of,member
R683 T4215 T4209 punct “,are
R684 T4367 T4368 det the,family
R685 T4368 T4366 pobj family,of
R686 T4369 T4370 punct [,10
R687 T4370 T4358 parataxis 10,considered
R688 T4216 T4217 compound activating,E2fs
R689 T4217 T4209 attr E2fs,are
R690 T4371 T4370 punct ],10
R691 T4372 T4358 punct .,considered
R692 T4218 T4217 punct ”,E2fs
R693 T4374 T4375 advmod However,reevaluated
R694 T4376 T4375 punct ", ",reevaluated
R695 T4219 T4220 dep that,required
R696 T4377 T4378 det this,view
R697 T4378 T4375 nsubjpass view,reevaluated
R698 T4220 T4217 relcl required,E2fs
R699 T4379 T4375 auxpass was,reevaluated
R700 T4380 T4381 advmod when,shown
R701 T4221 T4220 auxpass are,required
R702 T4381 T4375 advcl shown,reevaluated
R703 T4382 T4381 nsubjpass it,shown
R704 T4383 T4381 auxpass was,shown
R705 T4384 T4385 mark that,rescues
R706 T4222 T4220 prep for,required
R707 T4385 T4381 ccomp rescues,shown
R708 T4386 T4387 preconj either,E2f1
R709 T4387 T4388 nmod E2f1,deletion
R710 T4223 T4224 compound fibroblast,division
R711 T4388 T4385 nsubj deletion,rescues
R712 T4389 T4387 cc or,E2f1
R713 T4390 T4387 conj E2f3,E2f1
R714 T4224 T4222 pobj division,for
R715 T4391 T4385 dobj apoptosis,rescues
R716 T4392 T4385 prep in,rescues
R717 T4393 T4394 det the,system
R718 T4225 T4209 punct .,are
R719 T4394 T4392 pobj system,in
R720 T4395 T4394 amod developing,system
R721 T4396 T4394 amod central,system
R722 T4227 T4228 nsubj They,are
R723 T4397 T4394 amod nervous,system
R724 T4398 T4394 punct (,system
R725 T4399 T4394 appos CNS,system
R726 T4400 T4394 punct ),system
R727 T4229 T4230 amod strong,activators
R728 T4401 T4394 prep of,system
R729 T4402 T4403 compound Rb,KO
R730 T4403 T4404 compound KO,embryos
R731 T4404 T4401 pobj embryos,of
R732 T4230 T4228 attr activators,are
R733 T4405 T4406 punct [,11
R734 T4406 T4381 parataxis 11,shown
R735 T4407 T4406 nummod 6,11
R736 T4231 T4230 amod transcriptional,activators
R737 T4408 T4406 punct ",",11
R738 T4409 T4406 punct ],11
R739 T4410 T4375 punct .,reevaluated
R740 T4412 T4413 advmod Subsequently,shown
R741 T4232 T4233 dep that,drive
R742 T4414 T4413 punct ", ",shown
R743 T4415 T4416 compound CNS,apoptosis
R744 T4416 T4413 nsubjpass apoptosis,shown
R745 T4233 T4230 relcl drive,activators
R746 T4417 T4413 auxpass was,shown
R747 T4418 T4419 aux to,be
R748 T4419 T4413 xcomp be,shown
R749 T4234 T4233 aux can,drive
R750 T4420 T4421 det an,result
R751 T4421 T4419 attr result,be
R752 T4235 T4236 compound G0,fibroblasts
R753 T4422 T4421 amod indirect,result
R754 T4423 T4421 prep of,result
R755 T4424 T4425 amod placental,defects
R756 T4236 T4233 dobj fibroblasts,drive
R757 T4425 T4423 pobj defects,of
R758 T4426 T4425 cc and,defects
R759 T4427 T4428 amod probable,hypoxia
R760 T4237 T4233 prep into,drive
R761 T4428 T4425 conj hypoxia,defects
R762 T4429 T4430 punct [,12
R763 T4430 T4419 parataxis 12,be
R764 T4238 T4237 pobj cycle,into
R765 T4431 T4432 punct –,14
R766 T4432 T4430 prep 14,12
R767 T4433 T4430 punct ],12
R768 T4239 T4228 punct ", ",are
R769 T4240 T4228 cc and,are
R770 T4434 T4413 punct .,shown
R771 T4241 T4242 auxpass are,inhibited
R772 T4436 T4437 advmod Indeed,shown
R773 T4242 T4228 conj inhibited,are
R774 T4438 T4437 punct ", ",shown
R775 T4439 T4440 npadvmod E2f3,induced
R776 T4243 T4244 advmod when,bound
R777 T4440 T4442 amod induced,apoptosis
R778 T4441 T4440 punct -,induced
R779 T4442 T4437 nsubjpass apoptosis,shown
R780 T4244 T4242 advcl bound,inhibited
R781 T4443 T4442 prep in,apoptosis
R782 T4444 T4443 pobj fibroblasts,in
R783 T4245 T4244 prep to,bound
R784 T4445 T4437 aux has,shown
R785 T4446 T4437 advmod recently,shown
R786 T4447 T4437 auxpass been,shown
R787 T4246 T4245 pobj Rb,to
R788 T4448 T4449 aux to,require
R789 T4449 T4437 xcomp require,shown
R790 T4450 T4449 dobj E2f1,require
R791 T4451 T4452 punct [,15
R792 T4452 T4449 parataxis 15,require
R793 T4453 T4452 punct ],15
R794 T4247 T4248 punct [,5
R795 T4454 T4437 punct .,shown
R796 T4456 T4457 advmod Thus,is
R797 T4248 T4244 parataxis 5,bound
R798 T4458 T4457 punct ", ",is
R799 T4249 T4248 nummod 4,5
R800 T4459 T4457 nsubj it,is
R801 T4460 T4457 acomp controversial,is
R802 T4461 T4462 mark whether,required
R803 T4250 T4248 punct ",",5
R804 T4462 T4457 ccomp required,is
R805 T4463 T4462 nsubjpass E2f3,required
R806 T4464 T4462 auxpass is,required
R807 T4251 T4248 punct ],5
R808 T4465 T4462 prep for,required
R809 T4466 T4465 pobj apoptosis,for
R810 T4252 T4228 punct .,are
R811 T4467 T4466 prep of,apoptosis
R812 T4468 T4469 det any,type
R813 T4469 T4467 pobj type,of
R814 T4254 T4255 amod Ectopic,division
R815 T4470 T4471 compound Rb,KO
R816 T4471 T4469 compound KO,type
R817 T4472 T4469 compound cell,type
R818 T4473 T4457 punct .,is
R819 T4255 T4256 nsubjpass division,rescued
R820 T4475 T4476 csubj Determining,requires
R821 T4257 T4255 prep in,division
R822 T4258 T4259 compound Rb,KO
R823 T4259 T4260 compound KO,embryos
R824 T4477 T4478 det which,E2fs
R825 T4478 T4480 dep E2fs,promote
R826 T4479 T4478 amod activating,E2fs
R827 T4260 T4257 pobj embryos,in
R828 T4480 T4475 ccomp promote,Determining
R829 T4481 T4480 dobj death,promote
R830 T4482 T4480 prep in,promote
R831 T4261 T4256 aux can,rescued
R832 T4483 T4484 amod distinct,tissues
R833 T4484 T4482 pobj tissues,in
R834 T4485 T4486 compound Rb,KO
R835 T4262 T4256 auxpass be,rescued
R836 T4486 T4484 compound KO,tissues
R837 T4487 T4488 amod conditional,models
R838 T4263 T4256 prep to,rescued
R839 T4488 T4476 dobj models,requires
R840 T4489 T4490 advmod rather,than
R841 T4490 T4487 cc than,conditional
R842 T4491 T4492 compound germ,line
R843 T4492 T4487 conj line,conditional
R844 T4493 T4488 prep of,models
R845 T4264 T4265 amod various,extents
R846 T4494 T4495 compound Rb,deletion
R847 T4495 T4493 pobj deletion,of
R848 T4496 T4497 aux to,avoid
R849 T4582 T4580 cc and,quiescent
R850 T4497 T4476 advcl avoid,requires
R851 T4498 T4499 amod secondary,effects
R852 T4499 T4497 dobj effects,avoid
R853 T4500 T4499 amod indirect,effects
R854 T4501 T4499 punct (,effects
R855 T4583 T4580 conj dividing,quiescent
R856 T4502 T4503 amod such,as
R857 T4503 T4499 prep as,effects
R858 T4504 T4503 pobj hypoxia,as
R859 T4584 T4571 punct ", ",is
R860 T4505 T4476 punct ),requires
R861 T4506 T4476 punct .,requires
R862 T4585 T4571 cc and,is
R863 T4508 T4509 compound E2f,diversity
R864 T4509 T4511 nsubjpass diversity,expanded
R865 T4586 T4587 prep in,associates
R866 T4510 T4509 compound family,diversity
R867 T4512 T4511 auxpass is,expanded
R868 T4587 T4571 conj associates,is
R869 T4513 T4511 agent by,expanded
R870 T4514 T4515 compound E2f3,isoforms
R871 T4515 T4513 pobj isoforms,by
R872 T4516 T4511 punct .,expanded
R873 T4588 T4589 amod quiescent,fibroblasts
R874 T4518 T4519 amod Alternative,promoters
R875 T4589 T4586 pobj fibroblasts,in
R876 T4519 T4520 nsubj promoters,generate
R877 T4521 T4522 nummod two,forms
R878 T4590 T4587 nsubj it,associates
R879 T4522 T4520 dobj forms,generate
R880 T4523 T4522 punct (,forms
R881 T4524 T4522 appos a,forms
R882 T4591 T4592 advmod primarily,with
R883 T4592 T4587 prep with,associates
R884 T4525 T4524 cc and,a
R885 T4526 T4524 conj b,a
R886 T4593 T4592 pobj Rb,with
R887 T4527 T4522 punct ),forms
R888 T4528 T4529 dep that,are
R889 T4594 T4587 punct ", ",associates
R890 T4529 T4522 relcl are,forms
R891 T4530 T4529 acomp identical,are
R892 T4531 T4529 prep except,are
R893 T4595 T4587 advcl suggesting,associates
R894 T4532 T4531 prep for,except
R895 T4533 T4534 amod distinct,exons
R896 T4534 T4532 pobj exons,for
R897 T4535 T4534 amod first,exons
R898 T4536 T4537 punct [,16
R899 T4596 T4597 mark that,mediates
R900 T4537 T4520 parataxis 16,generate
R901 T4538 T4537 punct ],16
R902 T4597 T4595 ccomp mediates,suggesting
R903 T4539 T4520 punct .,generate
R904 T4541 T4542 nsubj E2f3a,is
R905 T4598 T4597 nsubj it,mediates
R906 T4543 T4544 det a,activator
R907 T4544 T4542 attr activator,is
R908 T4599 T4597 dobj repression,mediates
R909 T4545 T4544 amod strong,activator
R910 T4546 T4542 punct ", ",is
R911 T4547 T4542 cc and,is
R912 T4548 T4542 punct ", ",is
R913 T4600 T4601 punct [,16
R914 T4549 T4550 prep like,induced
R915 T4550 T4542 conj induced,is
R916 T4601 T4587 parataxis 16,associates
R917 T4551 T4552 amod other,E2fs
R918 T4602 T4603 punct –,18
R919 T4552 T4549 pobj E2fs,like
R920 T4553 T4552 amod activating,E2fs
R921 T4554 T4550 punct ", ",induced
R922 T4603 T4601 prep 18,16
R923 T4555 T4556 poss its,expression
R924 T4556 T4550 nsubjpass expression,induced
R925 T4557 T4550 auxpass is,induced
R926 T4604 T4601 punct ],16
R927 T4558 T4559 advmod when,stimulated
R928 T4559 T4550 advcl stimulated,induced
R929 T4560 T4561 amod quiescent,cells
R930 T4561 T4559 nsubjpass cells,stimulated
R931 T4605 T4587 punct .,associates
R932 T4562 T4559 auxpass are,stimulated
R933 T4563 T4564 aux to,divide
R934 T4564 T4559 xcomp divide,stimulated
R935 T4607 T4608 advmod Indeed,relies
R936 T4565 T4566 punct [,16
R937 T4566 T4559 parataxis 16,stimulated
R938 T4567 T4566 punct ],16
R939 T4568 T4550 punct .,induced
R940 T4609 T4608 punct ", ",relies
R941 T4570 T4571 nsubj E2f3b,is
R942 T4572 T4570 punct ", ",E2f3b
R943 T4610 T4608 csubj silencing,relies
R944 T4573 T4570 prep like,E2f3b
R945 T4574 T4575 amod repressive,E2fs
R946 T4575 T4573 pobj E2fs,like
R947 T4576 T4571 punct ", ",is
R948 T4577 T4571 acomp present,is
R949 T4578 T4571 prep in,is
R950 T4579 T4580 preconj both,quiescent
R951 T4611 T4612 det the,locus
R952 T4580 T4581 amod quiescent,cells
R953 T4581 T4578 pobj cells,in
R954 T4612 T4610 dobj locus,silencing
R955 T4613 T4612 nmod Cdkn2d,locus
R956 T4614 T4613 punct (,Cdkn2d
R957 T4615 T4613 appos p19Arf,Cdkn2d
R958 T4616 T4612 punct ),locus
R959 T4687 T4684 punct ],20
R960 T4617 T4610 prep in,silencing
R961 T4688 T4679 punct ", ",affects
R962 T4689 T4679 nsubj it,affects
R963 T4690 T4679 advmod also,affects
R964 T4618 T4619 amod unstressed,cells
R965 T4691 T4692 amod activating,E2fs
R966 T4692 T4679 dobj E2fs,affects
R967 T4619 T4617 pobj cells,in
R968 T4693 T4694 punct [,23
R969 T4694 T4679 parataxis 23,affects
R970 T4695 T4696 punct –,25
R971 T4620 T4608 prep on,relies
R972 T4696 T4694 prep 25,23
R973 T4697 T4694 punct ],23
R974 T4621 T4620 pobj E2f3b,on
R975 T4698 T4679 punct .,affects
R976 T4700 T4701 det The,distribution
R977 T4622 T4623 punct [,19
R978 T4701 T4702 nsubjpass distribution,assessed
R979 T4623 T4608 parataxis 19,relies
R980 T4703 T4701 prep of,distribution
R981 T4624 T4623 punct ],19
R982 T4704 T4705 compound E2f,isoforms
R983 T4705 T4703 pobj isoforms,of
R984 T4706 T4702 aux has,assessed
R985 T4625 T4608 punct .,relies
R986 T4707 T4702 neg never,assessed
R987 T4708 T4702 auxpass been,assessed
R988 T4709 T4702 punct .,assessed
R989 T4627 T4628 amod Other,E2fs
R990 T4711 T4712 nsubjpass It,known
R991 T4628 T4629 nsubj E2fs,exist
R992 T4713 T4712 aux has,known
R993 T4714 T4712 auxpass been,known
R994 T4630 T4629 aux may,exist
R995 T4715 T4712 prep for,known
R996 T4716 T4717 amod many,years
R997 T4717 T4715 pobj years,for
R998 T4718 T4719 mark that,perturbs
R999 T4719 T4712 ccomp perturbs,known
R1000 T4720 T4721 compound Rb,loss
R1001 T4721 T4719 nsubj loss,perturbs
R1002 T4722 T4723 amod neuronal,differentiation
R1003 T4631 T4629 advmod also,exist
R1004 T4723 T4719 dobj differentiation,perturbs
R1005 T4724 T4725 punct [,26
R1006 T4725 T4712 parataxis 26,known
R1007 T4632 T4629 prep in,exist
R1008 T4726 T4727 punct –,29
R1009 T4727 T4725 prep 29,26
R1010 T4728 T4725 punct ],26
R1011 T4633 T4632 pobj isoforms,in
R1012 T4729 T4712 punct .,known
R1013 T4731 T4732 advmod However,exclude
R1014 T4634 T4635 mark since,detected
R1015 T4733 T4732 punct ", ",exclude
R1016 T4734 T4735 amod prior,work
R1017 T4635 T4629 advcl detected,exist
R1018 T4735 T4732 nsubj work,exclude
R1019 T4736 T4732 aux could,exclude
R1020 T4737 T4732 neg not,exclude
R1021 T4636 T4637 advmod at,two
R1022 T4738 T4739 det the,possibility
R1023 T4739 T4732 dobj possibility,exclude
R1024 T4740 T4741 mark that,are
R1025 T4637 T4639 nummod two,mRNA
R1026 T4741 T4739 acl are,possibility
R1027 T4742 T4743 compound differentiation,defects
R1028 T4638 T4637 advmod least,two
R1029 T4743 T4741 nsubj defects,are
R1030 T4744 T4741 advmod simply,are
R1031 T4745 T4746 det an,consequence
R1032 T4639 T4640 compound mRNA,species
R1033 T4746 T4741 attr consequence,are
R1034 T4747 T4746 amod indirect,consequence
R1035 T4748 T4746 prep of,consequence
R1036 T4640 T4635 nsubjpass species,detected
R1037 T4749 T4750 amod abnormal,division
R1038 T4750 T4748 pobj division,of
R1039 T4751 T4750 cc and,division
R1040 T4641 T4635 aux have,detected
R1041 T4752 T4750 conj death,division
R1042 T4753 T4732 punct .,exclude
R1043 T4642 T4635 auxpass been,detected
R1044 T4755 T4756 mark If,regulate
R1045 T4756 T4759 advcl regulate,is
R1046 T4757 T4756 nsubj Rb,regulate
R1047 T4643 T4635 prep for,detected
R1048 T4758 T4756 aux does,regulate
R1049 T4760 T4756 dobj differentiation,regulate
R1050 T4761 T4756 advmod directly,regulate
R1051 T4762 T4759 nsubj it,is
R1052 T4763 T4759 acomp unclear,is
R1053 T4644 T4643 pobj E2f1,for
R1054 T4764 T4765 mark whether,does
R1055 T4765 T4759 ccomp does,is
R1056 T4766 T4765 nsubj it,does
R1057 T4645 T4644 cc and,E2f1
R1058 T4767 T4765 advmod so,does
R1059 T4768 T4765 prep in,does
R1060 T4769 T4768 pobj all,in
R1061 T4646 T4644 conj E2f2,E2f1
R1062 T4770 T4769 cc or,all
R1063 T4771 T4772 det a,subset
R1064 T4772 T4773 nmod subset,neurons
R1065 T4647 T4648 punct [,16
R1066 T4773 T4769 conj neurons,all
R1067 T4774 T4772 prep of,subset
R1068 T4648 T4635 parataxis 16,detected
R1069 T4775 T4759 punct .,is
R1070 T4777 T4778 advmod Moreover,solved
R1071 T4649 T4648 punct ],16
R1072 T4779 T4778 punct ", ",solved
R1073 T4780 T4781 det the,mechanism
R1074 T4650 T4629 punct .,exist
R1075 T4781 T4778 nsubjpass mechanism,solved
R1076 T4782 T4778 aux has,solved
R1077 T4783 T4778 neg never,solved
R1078 T4652 T4653 det The,roles
R1079 T4784 T4778 auxpass been,solved
R1080 T4785 T4778 punct .,solved
R1081 T4653 T4654 nsubj roles,are
R1082 T4787 T4788 prep In,seems
R1083 T4789 T4790 amod other,types
R1084 T4655 T4653 prep of,roles
R1085 T4790 T4787 pobj types,In
R1086 T4791 T4790 compound cell,types
R1087 T4792 T4793 advmod where,promote
R1088 T4656 T4657 compound E2f,isoforms
R1089 T4657 T4655 pobj isoforms,of
R1090 T4658 T4659 advmod in,vivo
R1091 T4659 T4653 advmod vivo,roles
R1092 T4793 T4790 relcl promote,types
R1093 T4794 T4793 nsubj Rb,promote
R1094 T4795 T4793 aux may,promote
R1095 T4660 T4654 acomp unknown,are
R1096 T4796 T4793 dobj differentiation,promote
R1097 T4797 T4793 advmod directly,promote
R1098 T4661 T4654 punct .,are
R1099 T4798 T4790 punct ", ",types
R1100 T4799 T4800 amod such,as
R1101 T4800 T4790 prep as,types
R1102 T4801 T4800 pobj muscle,as
R1103 T4802 T4801 cc and,muscle
R1104 T4663 T4664 nsubjpass E2fs,regulated
R1105 T4803 T4801 conj bone,muscle
R1106 T4804 T4788 punct ", ",seems
R1107 T4805 T4788 nsubj it,seems
R1108 T4806 T4807 aux to,do
R1109 T4807 T4788 xcomp do,seems
R1110 T4665 T4664 auxpass are,regulated
R1111 T4808 T4807 advmod so,do
R1112 T4809 T4807 prep through,do
R1113 T4810 T4811 npadvmod E2f,independent
R1114 T4811 T4813 amod independent,means
R1115 T4666 T4664 advmod also,regulated
R1116 T4812 T4811 punct -,independent
R1117 T4813 T4809 pobj means,through
R1118 T4814 T4807 prep by,do
R1119 T4667 T4664 agent by,regulated
R1120 T4815 T4814 pcomp potentiating,by
R1121 T4816 T4817 npadvmod tissue,specific
R1122 T4817 T4819 amod specific,factors
R1123 T4668 T4669 amod subcellular,localization
R1124 T4818 T4817 punct -,specific
R1125 T4819 T4815 dobj factors,potentiating
R1126 T4820 T4819 compound transcription,factors
R1127 T4669 T4667 pobj localization,by
R1128 T4821 T4822 punct (,1B
R1129 T4822 T4807 parataxis 1B,do
R1130 T4823 T4822 compound Figure,1B
R1131 T4670 T4664 punct .,regulated
R1132 T4824 T4822 punct ),1B
R1133 T4825 T4826 punct [,30
R1134 T4826 T4807 parataxis 30,do
R1135 T4672 T4673 mark Although,characterized
R1136 T4827 T4828 punct –,33
R1137 T4828 T4826 prep 33,30
R1138 T4829 T4826 punct ],30
R1139 T4673 T4679 advcl characterized,affects
R1140 T4830 T4788 punct .,seems
R1141 T4832 T4833 prep In,noted
R1142 T4674 T4675 det this,feature
R1143 T4834 T4835 det the,retina
R1144 T4835 T4832 pobj retina,In
R1145 T4675 T4673 nsubjpass feature,characterized
R1146 T4836 T4833 punct ", ",noted
R1147 T4837 T4833 nsubj others,noted
R1148 T4838 T4833 aux have,noted
R1149 T4676 T4673 aux has,characterized
R1150 T4839 T4840 advmod abnormally,shaped
R1151 T4840 T4841 amod shaped,rods
R1152 T4841 T4833 dobj rods,noted
R1153 T4842 T4843 compound Rb,KO
R1154 T4843 T4841 compound KO,rods
R1155 T4844 T4833 cc and,noted
R1156 T4845 T4846 aux have,suggested
R1157 T4677 T4673 auxpass been,characterized
R1158 T4846 T4833 conj suggested,noted
R1159 T4847 T4848 nsubj Rb,promote
R1160 T4848 T4846 advcl promote,suggested
R1161 T4849 T4848 aux may,promote
R1162 T4678 T4673 advmod best,characterized
R1163 T4850 T4848 advmod directly,promote
R1164 T4851 T4852 poss their,morphogenesis
R1165 T4680 T4673 prep for,characterized
R1166 T4852 T4848 dobj morphogenesis,promote
R1167 T4853 T4848 prep by,promote
R1168 T4854 T4853 pcomp activating,by
R1169 T4855 T4856 npadvmod retina,specific
R1170 T4681 T4682 amod repressive,E2fs
R1171 T4856 T4858 amod specific,factors
R1172 T4857 T4856 punct -,specific
R1173 T4858 T4854 dobj factors,activating
R1174 T4682 T4680 pobj E2fs,for
R1175 T4859 T4860 punct [,29
R1176 T4860 T4848 parataxis 29,promote
R1177 T4861 T4860 punct ],29
R1178 T4683 T4684 punct [,20
R1179 T4862 T4833 punct .,noted
R1180 T4684 T4673 parataxis 20,characterized
R1181 T4864 T4865 advmod However,be
R1182 T4685 T4686 punct –,22
R1183 T4866 T4865 punct ", ",be
R1184 T4867 T4868 compound differentiation,defects
R1185 T4868 T4865 nsubj defects,be
R1186 T4686 T4684 prep 22,20
R1187 T4869 T4868 prep in,defects
R1188 T4870 T4871 det any,neuron
R1189 T4871 T4869 pobj neuron,in
R1190 T4898 T4897 dobj differentiation,study
R1191 T4872 T4873 compound Rb,KO
R1192 T4873 T4871 compound KO,neuron
R1193 T4874 T4865 aux could,be
R1194 T4875 T4876 det an,effect
R1195 T4876 T4865 attr effect,be
R1196 T4899 T4898 prep of,differentiation
R1197 T4877 T4876 amod indirect,effect
R1198 T4878 T4876 prep of,effect
R1199 T4900 T4901 compound Rb,KO
R1200 T4901 T4902 compound KO,cells
R1201 T4879 T4880 amod ectopic,division
R1202 T4880 T4878 pobj division,of
R1203 T4881 T4880 cc and,division
R1204 T4902 T4899 pobj cells,of
R1205 T4882 T4881 punct /,and
R1206 T4883 T4881 cc or,and
R1207 T4884 T4880 conj apoptosis,division
R1208 T4885 T4886 punct (,1B
R1209 T4886 T4865 parataxis 1B,be
R1210 T4887 T4886 compound Figure,1B
R1211 T4903 T4897 prep in,study
R1212 T4888 T4886 punct ),1B
R1213 T4889 T4865 punct .,be
R1214 T4904 T4905 det the,absence
R1215 T4891 T4892 advmod Thus,is
R1216 T4893 T4892 punct ", ",is
R1217 T4905 T4903 pobj absence,in
R1218 T4894 T4892 nsubj it,is
R1219 T4895 T4892 acomp critical,is
R1220 T4906 T4905 prep of,absence
R1221 T4896 T4897 aux to,study
R1222 T4897 T4892 xcomp study,is
R1223 T4907 T4908 amod ectopic,proliferation
R1224 T4908 T4906 pobj proliferation,of
R1225 T5004 T5001 ccomp are,revealed
R1226 T4909 T4908 cc and,proliferation
R1227 T5005 T5006 det these,interneurons
R1228 T5006 T5004 nsubj interneurons,are
R1229 T5007 T5004 acomp critical,are
R1230 T4910 T4908 conj death,proliferation
R1231 T5008 T5007 prep for,critical
R1232 T5009 T5010 compound direction,selectivity
R1233 T5010 T5008 pobj selectivity,for
R1234 T4911 T4892 punct .,is
R1235 T5011 T5010 cc and,selectivity
R1236 T5012 T5013 advmod developmentally,important
R1237 T4913 T4914 advmod Here,establish
R1238 T5013 T5014 amod important,bursts
R1239 T5014 T5010 conj bursts,selectivity
R1240 T5015 T5014 amod rhythmic,bursts
R1241 T5016 T5017 punct [,34
R1242 T5017 T5004 parataxis 34,are
R1243 T4915 T4914 punct ", ",establish
R1244 T5018 T5019 punct –,36
R1245 T5019 T5017 prep 36,34
R1246 T5020 T5017 punct ],34
R1247 T5021 T5001 punct .,revealed
R1248 T4916 T4914 nsubj we,establish
R1249 T5023 T5024 advmod However,understood
R1250 T4917 T4918 mark that,suppresses
R1251 T5025 T5024 punct ", ",understood
R1252 T5026 T5027 poss their,differentiation
R1253 T4918 T4914 ccomp suppresses,establish
R1254 T5027 T5024 nsubjpass differentiation,understood
R1255 T5028 T5024 auxpass is,understood
R1256 T5029 T5024 advmod poorly,understood
R1257 T5030 T5024 punct .,understood
R1258 T5032 T5033 advcl Contrary,show
R1259 T4919 T4918 nsubj Rb,suppresses
R1260 T5034 T5032 prep to,Contrary
R1261 T4920 T4921 compound RTC,division
R1262 T5035 T5036 det the,view
R1263 T5036 T5034 pobj view,to
R1264 T5037 T5036 amod prevailing,view
R1265 T4921 T4918 dobj division,suppresses
R1266 T5038 T5039 mark that,promotes
R1267 T5039 T5036 acl promotes,view
R1268 T5040 T5039 nsubj Rb,promotes
R1269 T4922 T4921 cc and,division
R1270 T5041 T5039 dobj differentiation,promotes
R1271 T5042 T5039 prep through,promotes
R1272 T4923 T4921 conj death,division
R1273 T5043 T5044 npadvmod E2f,independent
R1274 T5044 T5046 amod independent,factors
R1275 T5045 T5044 punct -,independent
R1276 T4924 T4918 prep by,suppresses
R1277 T5046 T5042 pobj factors,through
R1278 T5047 T5048 npadvmod tissue,specific
R1279 T5048 T5046 amod specific,factors
R1280 T4925 T4924 pcomp inhibiting,by
R1281 T5049 T5048 punct -,specific
R1282 T5050 T5046 compound transcription,factors
R1283 T4926 T4925 dobj E2f1,inhibiting
R1284 T5051 T5033 punct ", ",show
R1285 T5052 T5033 nsubj we,show
R1286 T5053 T5054 mark that,facilitates
R1287 T4927 T4926 punct ", ",E2f1
R1288 T5054 T5033 ccomp facilitates,show
R1289 T5055 T5054 nsubj Rb,facilitates
R1290 T5056 T5057 compound SAC,development
R1291 T4928 T4926 cc not,E2f1
R1292 T4929 T4926 conj E2f2,E2f1
R1293 T5057 T5054 dobj development,facilitates
R1294 T5058 T5054 prep through,facilitates
R1295 T4930 T4929 cc or,E2f2
R1296 T5059 T5058 pobj E2f3,through
R1297 T5060 T5033 punct .,show
R1298 T4931 T4929 conj E2f3,E2f2
R1299 T5062 T5063 nsubj Defects,correlated
R1300 T5064 T5062 prep in,Defects
R1301 T4932 T4914 punct .,establish
R1302 T5065 T5066 npadvmod Rb,null
R1303 T5066 T5067 amod null,SACs
R1304 T5067 T5064 pobj SACs,in
R1305 T4934 T4935 advmod When,rescued
R1306 T5068 T5063 prep with,correlated
R1307 T5069 T5070 amod specific,expression
R1308 T5070 T5068 pobj expression,with
R1309 T5071 T5070 compound E2f3,expression
R1310 T5072 T5063 prep in,correlated
R1311 T5073 T5074 det these,cells
R1312 T4935 T4939 advcl rescued,survived
R1313 T5074 T5072 pobj cells,in
R1314 T4936 T4937 det these,defects
R1315 T4937 T4935 nsubjpass defects,rescued
R1316 T5075 T5063 punct ", ",correlated
R1317 T5076 T5063 cc and,correlated
R1318 T4938 T4935 auxpass were,rescued
R1319 T5077 T5078 compound E2f3,expression
R1320 T5078 T5079 nsubj expression,was
R1321 T4940 T4939 punct ", ",survived
R1322 T5079 T5063 conj was,correlated
R1323 T5080 T5079 acomp absent,was
R1324 T5081 T5079 prep in,was
R1325 T5082 T5081 pobj neurons,in
R1326 T4941 T4942 advmod most,neurons
R1327 T5083 T5084 dep that,differentiated
R1328 T5084 T5082 relcl differentiated,neurons
R1329 T5085 T5084 prep without,differentiated
R1330 T4942 T4939 nsubj neurons,survived
R1331 T5086 T5085 pobj Rb,without
R1332 T5087 T5079 punct .,was
R1333 T4943 T4942 amod retinal,neurons
R1334 T5089 T5090 nsubj E2f3,is
R1335 T4944 T4942 punct ", ",neurons
R1336 T5091 T5090 advmod also,is
R1337 T5092 T5090 acomp present,is
R1338 T5093 T5090 prep in,is
R1339 T4945 T4942 prep including,neurons
R1340 T5094 T5095 det a,subset
R1341 T5095 T5093 pobj subset,in
R1342 T5096 T5095 amod specific,subset
R1343 T4946 T4945 pobj rods,including
R1344 T5097 T5095 prep of,subset
R1345 T5098 T5099 amod other,neurons
R1346 T4947 T4939 punct ", ",survived
R1347 T5099 T5097 pobj neurons,of
R1348 T5100 T5099 compound CNS,neurons
R1349 T5101 T5090 punct ", ",is
R1350 T4948 T4939 punct ", ",survived
R1351 T5102 T5090 advcl implying,is
R1352 T5103 T5104 mark that,be
R1353 T5104 T5102 ccomp be,implying
R1354 T4949 T4939 conj differentiated,survived
R1355 T5105 T5104 nsubj this,be
R1356 T5106 T5104 aux may,be
R1357 T4950 T4949 punct ", ",differentiated
R1358 T5107 T5108 det a,mechanism
R1359 T5108 T5104 attr mechanism,be
R1360 T5109 T5108 amod general,mechanism
R1361 T4951 T4949 cc and,differentiated
R1362 T4952 T4949 conj functioned,differentiated
R1363 T5110 T5111 prep by,facilitates
R1364 T5111 T5108 relcl facilitates,mechanism
R1365 T5112 T5110 pobj which,by
R1366 T5113 T5111 nsubj Rb,facilitates
R1367 T4953 T4952 advmod normally,functioned
R1368 T5114 T5111 dobj neurogenesis,facilitates
R1369 T5115 T5090 punct .,is
R1370 T4954 T4939 punct .,survived
R1371 T5117 T5118 aux To,define
R1372 T4956 T4957 advmod Thus,function
R1373 T5118 T5119 advcl define,determined
R1374 T5120 T5121 det the,mechanism
R1375 T5121 T5118 dobj mechanism,define
R1376 T4958 T4957 punct ", ",function
R1377 T5122 T5118 prep in,define
R1378 T5123 T5124 advmod even,detail
R1379 T5124 T5122 pobj detail,in
R1380 T5125 T5124 amod more,detail
R1381 T4959 T4957 advmod unexpectedly,function
R1382 T5126 T5119 punct ", ",determined
R1383 T5127 T5119 nsubj we,determined
R1384 T5128 T5129 det which,isoform
R1385 T4960 T4957 punct ", ",function
R1386 T5129 T5131 dep isoform,targets
R1387 T5130 T5129 compound E2f3,isoform
R1388 T4961 T4962 npadvmod retina,specific
R1389 T5131 T5119 ccomp targets,determined
R1390 T5132 T5131 nsubj Rb,targets
R1391 T5133 T5134 aux to,control
R1392 T4962 T4964 amod specific,factors
R1393 T5134 T5131 advcl control,targets
R1394 T5135 T5136 compound SAC,differentiation
R1395 T4963 T4962 punct -,specific
R1396 T5136 T5134 dobj differentiation,control
R1397 T5137 T5119 punct .,determined
R1398 T4964 T4957 nsubj factors,function
R1399 T5139 T5140 nsubj E2f3b,mediates
R1400 T5141 T5142 compound Rb,function
R1401 T4965 T4964 compound differentiation,factors
R1402 T5142 T5140 dobj function,mediates
R1403 T5143 T5140 prep in,mediates
R1404 T4966 T4957 advmod independently,function
R1405 T5144 T5145 amod quiescent,fibroblasts
R1406 T5145 T5143 pobj fibroblasts,in
R1407 T4967 T4966 prep of,independently
R1408 T4968 T4967 pobj Rb,of
R1409 T5146 T5147 punct [,19
R1410 T5147 T5140 parataxis 19,mediates
R1411 T4969 T4957 punct .,function
R1412 T5148 T5147 punct ],19
R1413 T5149 T5140 punct ", ",mediates
R1414 T5150 T5140 cc yet,mediates
R1415 T5151 T5152 det no,studies
R1416 T5152 T5154 nsubj studies,dissected
R1417 T5153 T5152 amod prior,studies
R1418 T4971 T4972 advmod However,revealed
R1419 T5154 T5140 conj dissected,mediates
R1420 T5155 T5154 prep to,dissected
R1421 T5156 T5157 poss our,knowledge
R1422 T4973 T4972 punct ", ",revealed
R1423 T5157 T5155 pobj knowledge,to
R1424 T5158 T5154 aux have,dissected
R1425 T5159 T5160 nmod E2f3a,functions
R1426 T4974 T4975 amod comprehensive,assessment
R1427 T5160 T5154 dobj functions,dissected
R1428 T5161 T5159 cc or,E2f3a
R1429 T5162 T5159 conj E2f3b,E2f3a
R1430 T4975 T4972 nsubj assessment,revealed
R1431 T5163 T5164 advmod in,vivo
R1432 T5164 T5154 advmod vivo,dissected
R1433 T4976 T4975 prep of,assessment
R1434 T5165 T5154 punct .,dissected
R1435 T5167 T5168 advcl Using,show
R1436 T4977 T4978 det the,retina
R1437 T5169 T5170 det an,mouse
R1438 T4978 T4976 pobj retina,of
R1439 T5170 T5167 dobj mouse,Using
R1440 T5171 T5172 npadvmod isoform,specific
R1441 T5172 T5170 amod specific,mouse
R1442 T4979 T4980 compound Rb,E2f1
R1443 T5173 T5172 punct -,specific
R1444 T5174 T5170 amod null,mouse
R1445 T5175 T5168 nsubj we,show
R1446 T4980 T4982 npadvmod E2f1,null
R1447 T5176 T5177 mark that,drives
R1448 T5177 T5168 ccomp drives,show
R1449 T5178 T5177 nsubj Rb,drives
R1450 T4981 T4980 punct /,E2f1
R1451 T5179 T5180 compound SAC,differentiation
R1452 T5180 T5177 dobj differentiation,drives
R1453 T4982 T4978 amod null,retina
R1454 T5181 T5177 prep through,drives
R1455 T5182 T5181 pobj E2f3a,through
R1456 T5183 T5168 punct .,show
R1457 T4983 T4982 amod double,null
R1458 T5185 T5186 advmod Thus,regulate
R1459 T4984 T4982 punct -,null
R1460 T5187 T5186 punct ", ",regulate
R1461 T5188 T5186 advcl independent,regulate
R1462 T4985 T4978 amod rescued,retina
R1463 T5189 T5188 prep of,independent
R1464 T5190 T5191 npadvmod E2f1,mediated
R1465 T5191 T5193 amod mediated,effects
R1466 T5192 T5191 punct -,mediated
R1467 T5193 T5189 pobj effects,of
R1468 T5194 T5193 prep on,effects
R1469 T4986 T4987 det a,defect
R1470 T5195 T5194 pobj division,on
R1471 T5196 T5195 cc and,division
R1472 T5197 T5195 conj death,division
R1473 T4987 T4972 dobj defect,revealed
R1474 T5198 T5186 punct ", ",regulate
R1475 T5199 T5186 nsubj Rb,regulate
R1476 T4988 T4987 compound differentiation,defect
R1477 T5200 T5186 aux does,regulate
R1478 T5201 T5202 amod neuronal,differentiation
R1479 T5202 T5186 dobj differentiation,regulate
R1480 T4989 T4972 prep in,revealed
R1481 T5203 T5186 punct ", ",regulate
R1482 T5204 T5205 dep but,in
R1483 T4990 T4991 amod cholinergic,cells
R1484 T5205 T5186 prep in,regulate
R1485 T5206 T5205 advmod only,in
R1486 T5207 T5208 amod specific,neurons
R1487 T4991 T4989 pobj cells,in
R1488 T5208 T5205 pobj neurons,in
R1489 T5209 T5205 cc and,in
R1490 T4992 T4991 nmod starburst,cells
R1491 T5210 T5205 punct ", ",in
R1492 T5211 T5212 advmod unexpectedly,through
R1493 T4993 T4991 amod amacrine,cells
R1494 T5212 T5205 conj through,in
R1495 T5213 T5212 punct ", ",through
R1496 T5214 T5212 pobj E2f3a,through
R1497 T4994 T4991 punct (,cells
R1498 T5215 T5214 punct ", ",E2f3a
R1499 T4995 T4991 appos SACs,cells
R1500 T4996 T4972 punct ),revealed
R1501 T5216 T5214 cc not,E2f3a
R1502 T5217 T5218 npadvmod tissue,specific
R1503 T5218 T5220 amod specific,factors
R1504 T4997 T4972 punct .,revealed
R1505 T5219 T5218 punct -,specific
R1506 T5220 T5214 conj factors,E2f3a
R1507 T5221 T5220 compound differentiation,factors
R1508 T4999 T5000 amod Recent,breakthroughs
R1509 T5222 T5186 punct .,regulate
R1510 T5000 T5001 nsubj breakthroughs,revealed
R1511 T5002 T5001 aux have,revealed
R1512 T5003 T5004 mark that,are
R9941 T33426 T33427 nmod E2f1,Loss
R9942 T33427 T33435 nsubj Loss,Rescues
R9943 T33428 T33426 punct ", ",E2f1
R9944 T33429 T33426 cc but,E2f1
R9945 T33430 T33429 neg Not,but
R9946 T33431 T33426 conj E2f2,E2f1
R9947 T33432 T33431 cc or,E2f2
R9948 T33433 T33431 conj E2f3,E2f2
R9949 T33434 T33427 punct ", ",Loss
R9950 T33436 T33437 amod Ectopic,Division
R9951 T33437 T33435 dobj Division,Rescues
R9952 T33438 T33437 cc and,Division
R9953 T33439 T33440 compound Cell,Death
R9954 T33440 T33437 conj Death,Division
R9955 T33441 T33435 prep in,Rescues
R9956 T33442 T33443 det the,Retina
R9957 T33443 T33441 pobj Retina,in
R9958 T33444 T33445 compound Rb,KO
R9959 T33445 T33443 compound KO,Retina
R9960 T33447 T33448 punct (,A
R9961 T33448 T33449 meta A,development
R9962 T33450 T33448 punct ),A
R9963 T33451 T33449 amod Retinal,development
R9964 T33452 T33449 punct .,development
R9965 T33454 T33455 prep At,is
R9966 T33456 T33454 pobj E11,At
R9967 T33457 T33458 det the,retina
R9968 T33458 T33455 nsubj retina,is
R9969 T33459 T33460 det a,NBL
R9970 T33460 T33455 attr NBL,is
R9971 T33461 T33460 prep of,NBL
R9972 T33462 T33463 amod dividing,RPCs
R9973 T33463 T33461 pobj RPCs,of
R9974 T33464 T33465 punct (,nuclei
R9975 T33465 T33455 parataxis nuclei,is
R9976 T33466 T33467 amod white,circle
R9977 T33467 T33465 dep circle,nuclei
R9978 T33468 T33465 punct ", ",nuclei
R9979 T33469 T33465 amod green,nuclei
R9980 T33470 T33465 punct ),nuclei
R9981 T33471 T33455 punct .,is
R9982 T33473 T33474 compound RPC,bodies
R9983 T33474 T33476 nsubj bodies,oscillate
R9984 T33475 T33474 compound cell,bodies
R9985 T33477 T33476 prep along,oscillate
R9986 T33478 T33477 pobj processes,along
R9987 T33479 T33480 mark as,progress
R9988 T33480 T33476 advcl progress,oscillate
R9989 T33481 T33480 nsubj they,progress
R9990 T33482 T33480 prep through,progress
R9991 T33483 T33484 det the,cycle
R9992 T33484 T33482 pobj cycle,through
R9993 T33485 T33484 compound cell,cycle
R9994 T33486 T33476 punct .,oscillate
R9995 T33488 T33489 prep By,contains
R9996 T33490 T33488 pobj P0,By
R9997 T33491 T33492 det the,NBL
R9998 T33492 T33489 nsubj NBL,contains
R9999 T33493 T33494 preconj both,RPCs
R10000 T33494 T33489 dobj RPCs,contains
R10001 T33495 T33494 cc and,RPCs
R10002 T33496 T33497 amod post-mitotic,RTCs
R10003 T33497 T33494 conj RTCs,RPCs
R10004 T33498 T33499 punct (,nuclei
R10005 T33499 T33489 parataxis nuclei,contains
R10006 T33500 T33501 amod coloured,circles
R10007 T33501 T33499 dep circles,nuclei
R10008 T33502 T33499 punct ", ",nuclei
R10009 T33503 T33499 amod red,nuclei
R10010 T33504 T33499 punct ),nuclei
R10011 T33505 T33489 cc and,contains
R10012 T33506 T33507 auxpass is,separated
R10013 T33507 T33489 conj separated,contains
R10014 T33508 T33507 prep from,separated
R10015 T33509 T33510 det the,GCL
R10016 T33510 T33508 pobj GCL,from
R10017 T33511 T33507 agent by,separated
R10018 T33512 T33513 det the,IPL
R10019 T33513 T33511 pobj IPL,by
R10020 T33514 T33489 punct .,contains
R10021 T33516 T33517 prep By,are
R10022 T33518 T33516 pobj P8,By
R10023 T33519 T33517 expl there,are
R10024 T33520 T33521 det no,RPCs
R10025 T33521 T33517 attr RPCs,are
R10026 T33522 T33521 punct ", ",RPCs
R10027 T33523 T33524 amod fewer,RTCs
R10028 T33524 T33521 conj RTCs,RPCs
R10029 T33525 T33524 punct ", ",RTCs
R10030 T33526 T33527 det an,OPL
R10031 T33527 T33524 conj OPL,RTCs
R10032 T33528 T33527 punct ", ",OPL
R10033 T33529 T33527 cc and,OPL
R10034 T33530 T33531 amod more,rods
R10035 T33531 T33527 conj rods,OPL
R10036 T33532 T33531 amod differentiated,rods
R10037 T33533 T33531 punct (,rods
R10038 T33534 T33531 appos r,rods
R10039 T33535 T33531 punct ),rods
R10040 T33536 T33531 cc and,rods
R10041 T33537 T33531 conj cones,rods
R10042 T33538 T33537 punct (,cones
R10043 T33539 T33537 appos c,cones
R10044 T33540 T33517 punct ),are
R10045 T33541 T33517 prep in,are
R10046 T33542 T33543 det the,ONL
R10047 T33543 T33541 pobj ONL,in
R10048 T33544 T33517 punct ;,are
R10049 T33545 T33546 amod horizontal,cells
R10050 T33546 T33517 conj cells,are
R10051 T33547 T33548 punct (,h
R10052 T33548 T33545 parataxis h,horizontal
R10053 T33549 T33548 punct ),h
R10054 T33550 T33545 punct ", ",horizontal
R10055 T33551 T33545 conj bipolar,horizontal
R10056 T33552 T33553 punct (,b
R10057 T33553 T33551 parataxis b,bipolar
R10058 T33554 T33553 punct ),b
R10059 T33555 T33551 punct ", ",bipolar
R10060 T33556 T33551 conj Müller,bipolar
R10061 T33557 T33556 punct (,Müller
R10062 T33558 T33556 appos m,Müller
R10063 T33559 T33556 punct ),Müller
R10064 T33560 T33556 punct ", ",Müller
R10065 T33561 T33556 cc and,Müller
R10066 T33562 T33556 conj amacrine,Müller
R10067 T33563 T33564 punct (,a
R10068 T33564 T33562 parataxis a,amacrine
R10069 T33565 T33564 punct ),a
R10070 T33566 T33546 prep in,cells
R10071 T33567 T33568 det the,INL
R10072 T33568 T33566 pobj INL,in
R10073 T33569 T33546 punct ;,cells
R10074 T33570 T33546 cc and,cells
R10075 T33571 T33546 conj ganglion,cells
R10076 T33572 T33571 punct (,ganglion
R10077 T33573 T33571 appos g,ganglion
R10078 T33574 T33571 punct ),ganglion
R10079 T33575 T33571 cc and,ganglion
R10080 T33576 T33577 amod displaced,amacrine
R10081 T33577 T33578 nmod amacrine,cells
R10082 T33578 T33571 conj cells,ganglion
R10083 T33579 T33571 prep in,ganglion
R10084 T33580 T33581 det the,GCL
R10085 T33581 T33579 pobj GCL,in
R10086 T33582 T33517 punct .,are
R10087 T33584 T33585 nsubj Development,is
R10088 T33586 T33585 acomp complete,is
R10089 T33587 T33585 prep by,is
R10090 T33588 T33589 punct ~,P18
R10091 T33589 T33587 pobj P18,by
R10092 T33590 T33585 punct .,is
R10093 T33592 T33593 punct (,B
R10094 T33593 T33594 meta B,thought
R10095 T33595 T33593 punct ),B
R10096 T33596 T33594 nsubjpass Rb,thought
R10097 T33597 T33594 auxpass is,thought
R10098 T33598 T33599 aux to,regulate
R10099 T33599 T33594 xcomp regulate,thought
R10100 T33600 T33601 compound cell,cycle
R10101 T33601 T33599 dobj cycle,regulate
R10102 T33602 T33601 cc and,cycle
R10103 T33603 T33601 conj apoptosis,cycle
R10104 T33604 T33599 prep by,regulate
R10105 T33605 T33604 pcomp repressing,by
R10106 T33606 T33605 dobj E2fs,repressing
R10107 T33607 T33599 punct ", ",regulate
R10108 T33608 T33599 cc but,regulate
R10109 T33609 T33610 aux to,promote
R10110 T33610 T33599 conj promote,regulate
R10111 T33611 T33610 dobj differentiation,promote
R10112 T33612 T33611 prep by,differentiation
R10113 T33613 T33612 pcomp potentiating,by
R10114 T33614 T33615 npadvmod tissue,specific
R10115 T33615 T33617 amod specific,factors
R10116 T33616 T33615 punct -,specific
R10117 T33617 T33613 dobj factors,potentiating
R10118 T33618 T33617 compound transcription,factors
R10119 T33619 T33594 punct .,thought
R10120 T33621 T33622 advmod However,perturb
R10121 T33623 T33622 punct ", ",perturb
R10122 T33624 T33625 compound Rb,loss
R10123 T33625 T33622 nsubj loss,perturb
R10124 T33626 T33622 aux could,perturb
R10125 T33627 T33622 advmod also,perturb
R10126 T33628 T33622 dobj differentiation,perturb
R10127 T33629 T33622 prep through,perturb
R10128 T33630 T33631 det the,effects
R10129 T33631 T33629 pobj effects,through
R10130 T33632 T33631 amod indirect,effects
R10131 T33633 T33631 prep of,effects
R10132 T33634 T33635 amod abnormal,division
R10133 T33635 T33633 pobj division,of
R10134 T33636 T33635 cc or,division
R10135 T33637 T33635 conj death,division
R10136 T33638 T33629 punct ", ",through
R10137 T33639 T33629 cc and,through
R10138 T33640 T33639 punct /,and
R10139 T33641 T33639 cc or,and
R10140 T33642 T33629 conj through,through
R10141 T33643 T33644 amod direct,regulation
R10142 T33644 T33642 pobj regulation,through
R10143 T33645 T33644 prep of,regulation
R10144 T33646 T33647 compound differentiation,genes
R10145 T33647 T33645 pobj genes,of
R10146 T33648 T33644 prep by,regulation
R10147 T33649 T33648 pobj E2fs,by
R10148 T33650 T33622 punct .,perturb
R10149 T33652 T33653 punct (,C
R10150 T33653 T33654 meta C,stained
R10151 T33655 T33653 cc and,C
R10152 T33656 T33653 conj D,C
R10153 T33657 T33656 punct ),D
R10154 T33658 T33659 amod Horizontal,sections
R10155 T33659 T33654 nsubjpass sections,stained
R10156 T33660 T33659 amod retinal,sections
R10157 T33661 T33659 prep of,sections
R10158 T33662 T33663 det the,genotypes
R10159 T33663 T33661 pobj genotypes,of
R10160 T33664 T33663 amod indicated,genotypes
R10161 T33665 T33663 cc and,genotypes
R10162 T33666 T33663 conj ages,genotypes
R10163 T33667 T33654 auxpass were,stained
R10164 T33668 T33654 prep for,stained
R10165 T33669 T33668 pobj nuclei,for
R10166 T33670 T33671 punct (,blue
R10167 T33671 T33669 parataxis blue,nuclei
R10168 T33672 T33671 dep DAPI,blue
R10169 T33673 T33671 punct ", ",blue
R10170 T33674 T33671 punct ),blue
R10171 T33675 T33669 punct ", ",nuclei
R10172 T33676 T33669 cc and,nuclei
R10173 T33677 T33678 punct (,C
R10174 T33678 T33679 parataxis C,phase
R10175 T33679 T33669 conj phase,nuclei
R10176 T33680 T33678 punct ),C
R10177 T33681 T33679 compound S,phase
R10178 T33682 T33679 punct -,phase
R10179 T33683 T33684 punct (,red
R10180 T33684 T33679 parataxis red,phase
R10181 T33685 T33684 amod anti-BrdU,red
R10182 T33686 T33684 punct ", ",red
R10183 T33687 T33684 punct ),red
R10184 T33688 T33679 cc or,phase
R10185 T33689 T33690 punct (,D
R10186 T33690 T33691 parataxis D,apoptosis
R10187 T33691 T33679 conj apoptosis,phase
R10188 T33692 T33690 punct ),D
R10189 T33693 T33694 punct (,red
R10190 T33694 T33691 parataxis red,apoptosis
R10191 T33695 T33694 dep TUNEL,red
R10192 T33696 T33694 punct ", ",red
R10193 T33697 T33694 punct ),red
R10194 T33698 T33654 punct .,stained
R10195 T33700 T33701 compound Scale,bars
R10196 T33701 T33702 nsubj bars,are
R10197 T33703 T33704 nummod 50,μm
R10198 T33704 T33702 attr μm,are
R10199 T33705 T33702 punct .,are
R10200 T33707 T33708 punct (,E
R10201 T33708 T33709 meta E,Quantification
R10202 T33710 T33708 punct –,E
R10203 T33711 T33708 dep G,E
R10204 T33712 T33708 punct ),E
R10205 T33713 T33709 prep of,Quantification
R10206 T33714 T33715 punct (,E
R10207 T33715 T33716 parataxis E,cells
R10208 T33716 T33713 pobj cells,of
R10209 T33717 T33715 punct ),E
R10210 T33718 T33716 det all,cells
R10211 T33719 T33716 nmod BrdU,cells
R10212 T33720 T33719 punct +,BrdU
R10213 T33721 T33716 punct ", ",cells
R10214 T33722 T33723 punct (,F
R10215 T33723 T33724 parataxis F,cells
R10216 T33724 T33716 conj cells,cells
R10217 T33725 T33723 punct ),F
R10218 T33726 T33724 amod ectopic,cells
R10219 T33727 T33724 nmod BrdU,cells
R10220 T33728 T33727 punct +,BrdU
R10221 T33729 T33724 prep in,cells
R10222 T33730 T33729 pobj GCL,in
R10223 T33731 T33724 prep at,cells
R10224 T33732 T33731 pobj P0,at
R10225 T33733 T33724 punct ", ",cells
R10226 T33734 T33724 cc and,cells
R10227 T33735 T33736 punct (,G
R10228 T33736 T33737 parataxis G,cells
R10229 T33737 T33724 conj cells,cells
R10230 T33738 T33736 punct ),G
R10231 T33739 T33737 amod total,cells
R10232 T33740 T33737 nmod TUNEL,cells
R10233 T33741 T33740 punct +,TUNEL
R10234 T33742 T33709 punct .,Quantification
R10235 T33744 T33745 punct (,H
R10236 T33745 T33746 meta H,analysis
R10237 T33747 T33745 punct ),H
R10238 T33748 T33749 amod Real,time
R10239 T33749 T33751 compound time,PCR
R10240 T33750 T33749 punct -,time
R10241 T33751 T33746 compound PCR,analysis
R10242 T33752 T33751 compound RT,PCR
R10243 T33753 T33751 punct -,PCR
R10244 T33754 T33746 prep of,analysis
R10245 T33755 T33754 pobj E2fs,of
R10246 T33756 T33755 cc and,E2fs
R10247 T33757 T33758 compound E2f,genes
R10248 T33758 T33755 conj genes,E2fs
R10249 T33759 T33758 compound target,genes
R10250 T33760 T33746 prep in,analysis
R10251 T33761 T33762 compound P8,retinas
R10252 T33762 T33760 pobj retinas,in
R10253 T33763 T33762 prep of,retinas
R10254 T33764 T33765 det the,genotypes
R10255 T33765 T33763 pobj genotypes,of
R10256 T33766 T33765 amod indicated,genotypes
R10257 T33767 T33746 punct .,analysis
R10258 T33769 T33770 compound Error,bars
R10259 T33770 T33771 nsubj bars,represent
R10260 T33772 T33771 dobj SD,represent
R10261 T33773 T33772 prep of,SD
R10262 T33774 T33773 pobj measurements,of
R10263 T33775 T33774 prep from,measurements
R10264 T33776 T33777 nummod three,animals
R10265 T33777 T33775 pobj animals,from
R10266 T33778 T33771 punct ", ",represent
R10267 T33779 T33771 cc and,represent
R10268 T33780 T33781 nsubj asterisks,indicate
R10269 T33781 T33771 conj indicate,represent
R10270 T33782 T33783 det a,difference
R10271 T33783 T33781 dobj difference,indicate
R10272 T33784 T33783 amod significant,difference
R10273 T33785 T33783 prep between,difference
R10274 T33786 T33787 det the,genotypes
R10275 T33787 T33785 pobj genotypes,between
R10276 T33788 T33787 nmod WT,genotypes
R10277 T33789 T33788 cc and,WT
R10278 T33790 T33788 conj indicated,WT
R10279 T33791 T33792 punct (,test
R10280 T33792 T33781 parataxis test,indicate
R10281 T33793 T33794 punct *,0.05
R10282 T33794 T33792 ccomp 0.05,test
R10283 T33795 T33794 punct ", ",0.05
R10284 T33796 T33794 nsubj p,0.05
R10285 T33797 T33794 punct <,0.05
R10286 T33798 T33792 punct ;,test
R10287 T33799 T33800 punct **,0.01
R10288 T33800 T33792 ccomp 0.01,test
R10289 T33801 T33800 punct ;,0.01
R10290 T33802 T33800 nsubj p,0.01
R10291 T33803 T33800 punct <,0.01
R10292 T33804 T33792 punct ;,test
R10293 T33805 T33792 nmod ANOVA,test
R10294 T33806 T33805 cc and,ANOVA
R10295 T33807 T33808 compound Tukey,HSD
R10296 T33808 T33805 conj HSD,ANOVA
R10297 T33809 T33792 prep for,test
R10298 T33810 T33809 punct [,for
R10299 T33811 T33809 pobj E,for
R10300 T33812 T33813 punct –,G
R10301 T33813 T33811 prep G,E
R10302 T33814 T33792 punct ],test
R10303 T33815 T33792 cc and,test
R10304 T33816 T33817 compound Fisher,test
R10305 T33817 T33792 conj test,test
R10306 T33818 T33817 prep for,test
R10307 T33819 T33818 punct [,for
R10308 T33820 T33818 pobj H,for
R10309 T33821 T33792 punct ],test
R10310 T33822 T33792 punct ),test
R10311 T33823 T33781 punct .,indicate
R401 T4027 T4006 conj form,reside
R414 T4031 T4026 conj cells,ganglion
R418 T4032 T4033 det the,layer
R420 T4033 T4027 dobj layer,form
R425 T4034 T4035 compound ganglion,cell
R433 T4035 T4033 compound cell,layer
R437 T4036 T4033 punct (,layer
R441 T4037 T4033 appos GCL,layer
R445 T4038 T4027 punct ),form
R449 T4039 T4040 punct (,1A
R453 T4040 T4027 parataxis 1A,form
R454 T4041 T4040 compound Figure,1A
R455 T4042 T4040 punct ),1A
R456 T4043 T4027 punct .,form
R457 T4045 T4046 det The,layer
R458 T4046 T4049 nsubj layer,house
R459 T4047 T4046 amod outer,layer
R460 T4048 T4046 compound plexiform,layer
R461 T4050 T4046 punct (,layer
R462 T4051 T4046 appos OPL,layer
R464 T4052 T4046 punct ),layer
R465 T4053 T4046 cc and,layer
R466 T4054 T4055 amod inner,layer
R467 T4055 T4046 conj layer,layer
R468 T4056 T4055 compound plexiform,layer
R469 T4057 T4055 punct (,layer
R470 T4058 T4055 appos IPL,layer
R471 T4059 T4049 punct ),house
R472 T4060 T4061 amod synaptic,connections
R473 T4061 T4049 dobj connections,house
R474 T4062 T4061 acl separating,connections
R475 T4063 T4064 det the,INL
R476 T4064 T4062 dobj INL,separating
R477 T4065 T4064 compound ONL,INL
R478 T4066 T4064 punct /,INL
R479 T4067 T4064 cc and,INL
R480 T4068 T4069 compound INL,GCL
R463 T4086 T4083 conj o,s
R483 T4104 T4103 prep for,critical
R484 T4105 T4106 compound cell,cycle
R486 T4106 T4107 compound cycle,exit
R487 T4107 T4104 pobj exit,for
R489 T4109 T4110 amod retinal,cell
R490 T4110 T4112 compound cell,birth
R491 T4111 T4110 compound transition,cell
R493 T4112 T4108 pobj birth,during
R494 T4159 T4156 appos E2fs,factors
R495 T4115 T4116 nmod Rb,knockout
R496 T4116 T4117 nmod knockout,RTCs
R497 T4117 T4121 nsubj RTCs,continue
R498 T4118 T4116 punct (,knockout
R499 T4160 T4156 punct ),factors
R500 T4119 T4116 appos KO,knockout
R501 T4120 T4117 punct ),RTCs
R502 T4161 T4162 punct (,1B

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3555 35-41 UBERON:0000966 denotes retina
T3556 60-66 UBERON:0000479 denotes tissue
T3557 76-88 GO:0022008 denotes neurogenesis
T3558 161-168 UBERON:0000966 denotes retinal
T3559 161-184 CL:0002672 denotes retinal progenitor cell
T3560 180-184 CL_GO_EXT:cell denotes cell
T3561 180-184 _FRAGMENT denotes cell
T3562 191-204 GO:0008283 denotes proliferation
T3563 186-189 CL:0002672 denotes RPC
T3564 232-239 GO:0007067 denotes mitotic
T3565 240-247 UBERON:0000966 denotes retinal
T3566 259-264 CL_GO_EXT:cell denotes cells
T3567 330-345 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3568 361-365 CL_GO_EXT:cell denotes cell
T3569 389-393 CL:0002672 denotes RPCs
T3570 423-427 CL_GO_EXT:cell denotes cell
T3571 423-433 GO:0007049 denotes cell cycle
T3572 555-570 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3573 575-579 CL_GO_EXT:cell denotes cell
T3574 575-585 GO:0007049 denotes cell cycle
T3575 608-615 GO:0007067 denotes mitotic
T3576 621-628 GO_EXT:biological_movement_or_translocation_process denotes migrate
T3577 648-662 UBERON:0001781 denotes retinal layers
T3578 664-668 CL:0000604 denotes Rods
T3579 673-678 CL:0000573 denotes cones
T3580 691-710 UBERON:0001789 denotes outer nuclear layer
T3581 697-704 GO:0005634 denotes nuclear
T3582 712-715 UBERON:0001789 denotes ONL
T3583 718-728 _FRAGMENT denotes horizontal
T3584 752-757 CL:0000745 denotes cells
T3585 730-737 _FRAGMENT denotes bipolar
T3586 752-757 CL:0000103 denotes cells
T3587 743-757 CL:0000561 denotes amacrine cells
T3588 752-757 CL_GO_EXT:cell denotes cells
T3589 770-786 CL:0011107 denotes Müller glia cell
T3590 782-793 GO:0044297 denotes cell bodies
T3591 809-828 UBERON:0001791 denotes inner nuclear layer
T3592 815-822 GO:0005634 denotes nuclear
T3593 830-833 UBERON:0001791 denotes INL
T3594 840-848 UBERON:0000045 denotes ganglion
T3595 840-848 _FRAGMENT denotes ganglion
T3596 872-877 CL:0000740 denotes cells
T3644 2983-2993 GO:0007049 denotes cell cycle
T3645 2997-3004 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T3646 3020-3023 PR_EXT:E2F denotes E2f
T3647 3024-3037 GO_EXT:transcription denotes transcription
T3648 3024-3045 GO_EXT:transcription_factor denotes transcription factors
T3649 3047-3051 PR_EXT:E2F denotes E2fs
T3650 3083-3096 GO_EXT:transcription denotes transcription
T3651 3083-3104 GO_EXT:transcription_factor denotes transcription factors
T3652 3110-3114 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T3653 3115-3125 NCBITaxon:10508 denotes adenoviral
T3654 3129-3139 GO:0065007 denotes regulatory
T3655 3129-3148 SO_EXT:0005836 denotes regulatory elements
T3656 3187-3191 CL_GO_EXT:cell denotes cell
T3657 3187-3197 GO:0007049 denotes cell cycle
T3658 3198-3208 GO_EXT:regulator denotes regulators
T3659 3216-3220 PR_EXT:E2F denotes E2fs
T3660 3221-3225 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T3661 3229-3232 CHEBI_SO_EXT:DNA denotes DNA
T3662 3242-3248 GO_EXT:dimer_macromolecular_complex denotes dimers
T3663 3254-3262 CHEBI_PR_EXT:protein denotes proteins
T3664 3278-3282 PR_EXT:TFDP denotes Tfdp
T3665 3291-3295 PR_EXT:000006852 denotes E2f1
T3666 3297-3301 PR_EXT:000006853 denotes E2f2
T3667 3307-3312 PR_EXT:000028775 denotes E2f3a
T3668 3329-3333 PR_EXT:E2F denotes E2fs
T3669 3357-3367 CL:0000057 denotes fibroblast
T3670 3394-3409 GO_EXT:transcription denotes transcriptional
T3671 3439-3450 CL:0000057 denotes fibroblasts
T3672 3486-3491 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bound
T3673 3495-3497 PR_EXT:000013773 denotes Rb
T3674 3525-3527 PR_EXT:000013773 denotes Rb
T3675 3531-3538 UBERON:0000922 denotes embryos
T3676 3546-3553 SO_EXT:sequence_rescue_process denotes rescued
T3677 3586-3593 UBERON:0000479 denotes tissues
T3678 3610-3614 PR_EXT:000006852 denotes E2f1
T3679 3616-3620 PR_EXT:000006853 denotes E2f2
T3680 3625-3629 PR_EXT:000006854 denotes E2f3
T3681 3675-3677 PR_EXT:000013773 denotes Rb
T3682 3735-3739 PR_EXT:000006855 denotes E2f4
T3683 3744-3748 PR_EXT:000006856 denotes E2f5
T3684 3775-3779 PR_EXT:E2F denotes E2fs
T3685 3853-3857 SO_EXT:0000704 denotes gene
T3686 3853-3867 GO:0016458 denotes gene silencing
T3687 3871-3880 GO:0044838 denotes quiescent
T3688 3884-3898 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T3689 3899-3904 CL_GO_EXT:cell denotes cells
T3690 3917-3921 PR_EXT:E2F denotes E2fs
T3691 3939-3948 GO:0006915 denotes apoptosis
T3692 3956-3958 PR_EXT:000013773 denotes Rb
T3693 3962-3968 UBERON:0000966 denotes retina
T3694 3994-3998 PR_EXT:000006852 denotes E2f1
T3695 4030-4039 GO_PATO_EXT:apoptotic_process_or_quality denotes apoptotic
T3696 4132-4136 PR_EXT:000006852 denotes E2f1
T3697 4140-4144 PR_EXT:000006854 denotes E2f3
T3698 4145-4153 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T3699 4154-4161 SO_EXT:sequence_rescue_process denotes rescues
T3700 4162-4171 GO:0006915 denotes apoptosis
T3701 4190-4212 UBERON:0001017 denotes central nervous system
T3702 4214-4217 UBERON:0001017 denotes CNS
T3703 4222-4224 PR_EXT:000013773 denotes Rb
T3704 4228-4235 UBERON:0000922 denotes embryos
T3705 4258-4261 UBERON:0001017 denotes CNS
T3706 4262-4271 GO:0006915 denotes apoptosis
T3707 4310-4319 UBERON:0001987 denotes placental
T3708 4366-4370 PR_EXT:000006854 denotes E2f3
T3709 4379-4388 GO:0006915 denotes apoptosis
T3710 4392-4403 CL:0000057 denotes fibroblasts
T3711 4439-4443 PR_EXT:000006852 denotes E2f1
T3712 4484-4488 PR_EXT:000006854 denotes E2f3
T3713 4505-4514 GO:0006915 denotes apoptosis
T3714 4522-4524 PR_EXT:000013773 denotes Rb
T3715 4528-4532 CL_GO_EXT:cell denotes cell
T3716 4568-4572 PR_EXT:E2F denotes E2fs
T3717 4581-4586 GO:0016265 denotes death
T3718 4599-4601 PR_EXT:000013773 denotes Rb
T3719 4605-4612 UBERON:0000479 denotes tissues
T3720 4666-4668 PR_EXT:000013773 denotes Rb
T3721 4669-4677 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T3722 4733-4736 PR_EXT:E2F denotes E2f
T3723 4769-4773 PR_EXT:000006854 denotes E2f3
T3724 4774-4782 SO_EXT:0001060 denotes isoforms
T3725 4796-4805 SO_EXT:0000167 denotes promoters
T3726 4880-4885 SO_EXT:0000147 denotes exons
T3727 4892-4897 PR_EXT:000028775 denotes E2f3a
T3728 4948-4952 PR_EXT:E2F denotes E2fs
T3729 4958-4968 GO:0010467 denotes expression
T3730 4985-4994 GO:0044838 denotes quiescent
T3731 4995-5000 CL_GO_EXT:cell denotes cells
T3732 5055-5059 PR_EXT:E2F denotes E2fs
T3733 5080-5089 GO:0044838 denotes quiescent
T3734 5103-5108 CL_GO_EXT:cell denotes cells
T3735 5117-5126 GO:0044838 denotes quiescent
T3736 5127-5138 CL:0000057 denotes fibroblasts
T3737 5168-5170 PR_EXT:000013773 denotes Rb
T3738 5228-5237 GO:0016458 denotes silencing
T3739 5242-5248 PR_EXT:000005279 denotes Cdkn2d
T3740 5250-5256 PR_EXT:000005279 denotes p19Arf
T3741 5278-5283 CL_GO_EXT:cell denotes cells
T3742 5312-5316 PR_EXT:E2F denotes E2fs
T3743 5335-5343 SO_EXT:0001060 denotes isoforms
T3744 5363-5367 CHEBI_SO_EXT:mRNA denotes mRNA
T3745 5399-5403 PR_EXT:000006852 denotes E2f1
T3746 5408-5412 PR_EXT:000006853 denotes E2f2
T3747 5432-5435 PR_EXT:E2F denotes E2f
T3748 5436-5444 SO_EXT:0001060 denotes isoforms
T3749 5466-5470 PR_EXT:E2F denotes E2fs
T3750 5480-5489 GO:0065007 denotes regulated
T3751 5493-5504 GO_UBERON_EXT:cellular_component_or_cell_part denotes subcellular
T3752 5496-5504 CL_GO_EXT:cell denotes cellular
T3753 5505-5517 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T3754 5584-5588 PR_EXT:E2F denotes E2fs
T3755 5625-5629 PR_EXT:E2F denotes E2fs
T3756 5659-5662 PR_EXT:E2F denotes E2f
T3757 5663-5671 SO_EXT:0001060 denotes isoforms
T3758 5735-5737 PR_EXT:000013773 denotes Rb
T3759 5752-5760 CL:0000540 denotes neuronal
T3760 5761-5776 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3761 5845-5860 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3762 5929-5934 GO:0016265 denotes death
T3763 5939-5941 PR_EXT:000013773 denotes Rb
T3764 5947-5955 GO:0065007 denotes regulate
T3765 5956-5971 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3766 6036-6043 CL:0000540 denotes neurons
T3767 6101-6105 CL_GO_EXT:cell denotes cell
T3768 6118-6120 PR_EXT:000013773 denotes Rb
T3769 6133-6148 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3770 6167-6173 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T3771 6178-6182 UBERON_EXT:bone_element_or_tissue denotes bone
T3772 6210-6213 PR_EXT:E2F denotes E2f
T3773 6248-6254 UBERON:0000479 denotes tissue
T3774 6264-6277 GO_EXT:transcription denotes transcription
T3775 6264-6285 GO_EXT:transcription_factor denotes transcription factors
T3776 6314-6320 UBERON:0000966 denotes retina
T3777 6358-6360 PR_EXT:000013773 denotes Rb
T3778 6364-6368 CL:0000604 denotes rods
T3779 6388-6390 PR_EXT:000013773 denotes Rb
T3780 6418-6431 GO:0009653 denotes morphogenesis
T3781 6446-6452 UBERON:0000966 denotes retina
T3782 6485-6500 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3783 6516-6518 PR_EXT:000013773 denotes Rb
T3784 6522-6528 CL:0000540 denotes neuron
T3785 6584-6593 GO:0006915 denotes apoptosis
T3786 6637-6655 _FRAGMENT denotes differentiation of
T3787 6662-6667 GO:0030154 denotes cells
T3788 6656-6658 PR_EXT:000013773 denotes Rb
T3789 6662-6667 CL_GO_EXT:cell denotes cells
T3790 6694-6707 GO:0008283 denotes proliferation
T3791 6712-6717 GO:0016265 denotes death
T3792 6743-6745 PR_EXT:000013773 denotes Rb
T3793 6774-6779 GO:0016265 denotes death
T3794 6794-6798 PR_EXT:000006852 denotes E2f1
T3795 6804-6808 PR_EXT:000006853 denotes E2f2
T3796 6812-6816 PR_EXT:000006854 denotes E2f3
T3797 6842-6849 SO_EXT:sequence_rescue_process denotes rescued
T3798 6856-6863 UBERON:0000966 denotes retinal
T3799 6864-6871 CL:0000540 denotes neurons
T3800 6883-6887 CL:0000604 denotes rods
T3801 6899-6913 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T3802 6960-6966 UBERON:0000966 denotes retina
T3803 6976-6991 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3804 7026-7028 PR_EXT:000013773 denotes Rb
T3805 7071-7073 PR_EXT:000013773 denotes Rb
T3806 7074-7078 PR_EXT:000006852 denotes E2f1
T3807 7086-7090 SO_EXT:sequence_nullness denotes null
T3808 7091-7098 SO_EXT:sequence_rescue_process denotes rescued
T3809 7099-7105 UBERON:0000966 denotes retina
T3810 7117-7132 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3811 7143-7154 CHEBI:15355 denotes cholinergic
T3812 7165-7179 CL:0000561 denotes amacrine cells
T3813 7174-7179 CL_GO_EXT:cell denotes cells
T3814 7234-7246 CL:0000099 denotes interneurons
T3815 7356-7371 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3816 7431-7433 PR_EXT:000013773 denotes Rb
T3817 7443-7458 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3818 7467-7470 PR_EXT:E2F denotes E2f
T3819 7483-7489 UBERON:0000479 denotes tissue
T3820 7499-7512 GO_EXT:transcription denotes transcription
T3821 7499-7520 GO_EXT:transcription_factor denotes transcription factors
T3822 7535-7537 PR_EXT:000013773 denotes Rb
T3823 7574-7578 PR_EXT:000006854 denotes E2f3
T3824 7591-7593 PR_EXT:000013773 denotes Rb
T3825 7594-7598 SO_EXT:sequence_nullness denotes null
T3826 7629-7633 PR_EXT:000006854 denotes E2f3
T3827 7634-7644 GO:0010467 denotes expression
T3828 7654-7659 CL_GO_EXT:cell denotes cells
T3829 7665-7669 PR_EXT:000006854 denotes E2f3
T3830 7670-7680 GO:0010467 denotes expression
T3831 7695-7702 CL:0000540 denotes neurons
T3832 7708-7722 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T3833 7731-7733 PR_EXT:000013773 denotes Rb
T3834 7735-7739 PR_EXT:000006854 denotes E2f3
T3835 7786-7789 UBERON:0001017 denotes CNS
T3836 7786-7797 CL:0000117 denotes CNS neurons
T3837 7854-7856 PR_EXT:000013773 denotes Rb
T3838 7869-7881 GO:0022008 denotes neurogenesis
T3839 7948-7952 PR_EXT:000006854 denotes E2f3
T3840 7953-7960 SO_EXT:0001060 denotes isoform
T3841 7961-7963 PR_EXT:000013773 denotes Rb
T3842 7975-7982 GO:0065007 denotes control
T3843 7987-8002 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3844 8019-8021 PR_EXT:000013773 denotes Rb
T3845 8034-8043 GO:0044838 denotes quiescent
T3846 8044-8055 CL:0000057 denotes fibroblasts
T3847 8115-8120 PR_EXT:000028775 denotes E2f3a
T3848 8158-8165 SO_EXT:0001060 denotes isoform
T3849 8175-8179 SO_EXT:sequence_nullness denotes null
T3850 8180-8185 NCBITaxon:10088 denotes mouse
T3851 8199-8201 PR_EXT:000013773 denotes Rb
T3852 8213-8228 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3853 8237-8242 PR_EXT:000028775 denotes E2f3a
T3854 8265-8269 PR_EXT:000006852 denotes E2f1
T3855 8303-8308 GO:0016265 denotes death
T3856 8310-8312 PR_EXT:000013773 denotes Rb
T3857 8318-8326 GO:0065007 denotes regulate
T3858 8327-8335 CL:0000540 denotes neuronal
T3859 8336-8351 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3860 8374-8381 CL:0000540 denotes neurons
T3861 8409-8414 PR_EXT:000028775 denotes E2f3a
T3862 8420-8426 UBERON:0000479 denotes tissue
T3863 8436-8451 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T33335 1077-1081 PR_EXT:000006852 denotes E2f1
T33336 1091-1095 PR_EXT:000006853 denotes E2f2
T33337 1099-1103 PR_EXT:000006854 denotes E2f3
T33338 1110-1117 SO_EXT:sequence_rescue_process denotes Rescues
T33339 1139-1143 CL_GO_EXT:cell denotes Cell
T33340 1139-1149 GO:0008219 denotes Cell Death
T33341 1157-1159 PR_EXT:000013773 denotes Rb
T33342 1163-1169 UBERON:0000966 denotes Retina
T33343 1174-1181 UBERON:0000966 denotes Retinal
T33344 1174-1193 GO:0060041 denotes Retinal development
T33345 1206-1212 UBERON:0000966 denotes retina
T33346 1234-1238 CL:0002672 denotes RPCs
T33347 1260-1266 GO:0005634 denotes nuclei
T33348 1269-1272 CL:0002672 denotes RPC
T33349 1273-1277 CL_GO_EXT:cell denotes cell
T33350 1273-1284 GO:0044297 denotes cell bodies
T33351 1301-1310 GO:0042995 denotes processes
T33352 1340-1344 CL_GO_EXT:cell denotes cell
T33353 1340-1350 GO:0007049 denotes cell cycle
T33354 1380-1384 CL:0002672 denotes RPCs
T33355 1394-1401 GO:0007067 denotes mitotic
T33356 1430-1436 GO:0005634 denotes nuclei
T33357 1464-1467 UBERON:0001792 denotes GCL
T33358 1499-1503 CL:0002672 denotes RPCs
T33359 1534-1548 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T33360 1549-1553 CL:0000604 denotes rods
T33361 1555-1556 CL:0000604 denotes r
T33362 1562-1567 CL:0000573 denotes cones
T33363 1569-1570 CL:0000573 denotes c
T33364 1579-1582 UBERON:0001789 denotes ONL
T33365 1584-1594 _FRAGMENT denotes horizontal
T33366 1642-1647 CL:0000745 denotes cells
T33367 1596-1597 CL:0000745 denotes h
T33368 1600-1607 _FRAGMENT denotes bipolar
T33369 1642-1647 CL:0000103 denotes cells
T33370 1609-1610 CL:0000103 denotes b
T33371 1613-1619 _FRAGMENT denotes Müller
T33372 1642-1647 CL:0011107 denotes cells
T33373 1621-1622 CL:0011107 denotes m
T33374 1629-1637 _FRAGMENT denotes amacrine
T33375 1642-1647 CL:0000561 denotes cells
T33376 1639-1640 CL:0000561 denotes a
T33377 1642-1647 CL_GO_EXT:cell denotes cells
T33378 1655-1658 UBERON:0001791 denotes INL
T33379 1664-1672 UBERON:0000045 denotes ganglion
T33380 1664-1672 _FRAGMENT denotes ganglion
T33381 1700-1705 CL:0000740 denotes cells
T33382 1674-1675 UBERON:0000045 denotes g
T33383 1674-1675 _FRAGMENT denotes g
T33384 1691-1705 CL:0000561 denotes amacrine cells
T33385 1700-1705 CL_GO_EXT:cell denotes cells
T33386 1713-1716 UBERON:0001792 denotes GCL
T33387 1755-1757 PR_EXT:000013773 denotes Rb
T33388 1772-1780 GO:0065007 denotes regulate
T33389 1781-1785 CL_GO_EXT:cell denotes cell
T33390 1781-1791 GO:0007049 denotes cell cycle
T33391 1796-1805 GO:0006915 denotes apoptosis
T33392 1820-1824 PR_EXT:E2F denotes E2fs
T33393 1841-1856 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T33394 1873-1879 UBERON:0000479 denotes tissue
T33395 1889-1902 GO_EXT:transcription denotes transcription
T33396 1889-1910 GO_EXT:transcription_factor denotes transcription factors
T33397 1921-1923 PR_EXT:000013773 denotes Rb
T33398 1948-1963 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T33399 2017-2022 GO:0016265 denotes death
T33400 2046-2056 GO:0065007 denotes regulation
T33401 2060-2075 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T33402 2076-2081 SO_EXT:0000704 denotes genes
T33403 2085-2089 PR_EXT:E2F denotes E2fs
T33404 2112-2119 UBERON:0000966 denotes retinal
T33405 2146-2155 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T33406 2182-2188 GO:0005634 denotes nuclei
T33407 2190-2194 CHEBI:51231 denotes DAPI
T33408 2211-2218 GO:0051320 denotes S-phase
T33409 2225-2229 CHEBI:472552 denotes BrdU
T33410 2243-2252 GO:0006915 denotes apoptosis
T33411 2321-2325 CHEBI:472552 denotes BrdU
T33412 2327-2332 CL_GO_EXT:cell denotes cells
T33413 2346-2350 CHEBI:472552 denotes BrdU
T33414 2352-2357 CL_GO_EXT:cell denotes cells
T33415 2361-2364 UBERON:0001792 denotes GCL
T33416 2393-2398 CL_GO_EXT:cell denotes cells
T33417 2414-2416 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T33418 2433-2437 PR_EXT:E2F denotes E2fs
T33419 2442-2445 PR_EXT:E2F denotes E2f
T33420 2453-2458 SO_EXT:0000704 denotes genes
T33421 2465-2472 UBERON:0000966 denotes retinas
T33422 2490-2499 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T33423 2552-2559 NCBITaxon:33208 denotes animals
T33424 2621-2623 SO_EXT:wild_type_entity_or_quality denotes WT
T33425 2638-2647 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T3642 2970-2978 GO:0065007 denotes controls
T3643 2983-2987 CL_GO_EXT:cell denotes cell
T3597 863-877 CL:0000561 denotes amacrine cells
T3598 872-877 CL_GO_EXT:cell denotes cells
T3599 887-900 CL:0000740 denotes ganglion cell
T3600 887-906 UBERON:0001792 denotes ganglion cell layer
T3601 896-900 CL_GO_EXT:cell denotes cell
T3602 908-911 UBERON:0001792 denotes GCL
T3603 930-951 UBERON:0001790 denotes outer plexiform layer
T3604 953-956 UBERON:0001790 denotes OPL
T3605 962-983 UBERON:0001795 denotes inner plexiform layer
T3606 985-988 UBERON:0001795 denotes IPL
T3607 996-1016 GO:0045202 denotes synaptic connections
T3608 1032-1035 UBERON:0001789 denotes ONL
T3609 1036-1039 UBERON:0001791 denotes INL
T3610 1044-1047 UBERON:0001791 denotes INL
T3611 1048-1051 UBERON:0001792 denotes GCL
T3612 2741-2743 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes ti
T3613 2744-2745 CL:0000573 denotes o
T3614 2748-2749 CL:0000745 denotes s
T3615 2745-2748 _FRAGMENT denotes bla
T3616 2748-2749 CL:0000103 denotes s
T3617 2748-2749 CL:0011107 denotes s
T3618 2748-2749 CL:0000561 denotes s
T3619 2748-2749 CL_GO_EXT:cell denotes s
T3620 2750-2751 UBERON:0000045 denotes o
T3621 2750-2751 _FRAGMENT denotes o
T3622 2751-2754 CL:0000561 denotes ma
T3623 2755-2756 GO:0065007 denotes r
T3624 2756-2758 GO:0006915 denotes ot
T3625 2767-2770 PR_EXT:000013773 denotes is
T3626 2783-2787 CL_GO_EXT:cell denotes cell
T3627 2783-2793 GO:0007049 denotes cell cycle
T3628 2806-2813 UBERON:0000966 denotes retinal
T3629 2825-2829 CL_GO_EXT:cell denotes cell
T3630 2837-2839 PR_EXT:000013773 denotes Rb
T3631 2871-2882 GO:0008283 denotes proliferate
T3632 2909-2912 _FRAGMENT denotes rod
T3633 2936-2941 CL:0000604 denotes cells
T3634 2914-2922 UBERON:0000045 denotes ganglion
T3635 2914-2922 _FRAGMENT denotes ganglion
T3636 2936-2941 CL:0000740 denotes cells
T3637 2928-2941 CL:0000103 denotes bipolar cells
T3638 2936-2941 CL_GO_EXT:cell denotes cells
T3639 2943-2946 GO:0016265 denotes die
T3640 2950-2959 GO:0006915 denotes apoptosis
T3641 2967-2969 PR_EXT:000013773 denotes Rb
R9935 T33366 T33365 _lexicallyChainedTo cells,horizontal
R9936 T33369 T33368 _lexicallyChainedTo cells,bipolar
R9937 T33372 T33371 _lexicallyChainedTo cells,Müller
R9938 T33375 T33374 _lexicallyChainedTo cells,amacrine
R9939 T33381 T33380 _lexicallyChainedTo cells,ganglion
R9940 T33381 T33383 _lexicallyChainedTo cells,g
R283 T3596 T3595 _lexicallyChainedTo cells,ganglion
R284 T3616 T3615 _lexicallyChainedTo s,bla
R286 T3633 T3632 _lexicallyChainedTo cells,rod
R287 T3636 T3635 _lexicallyChainedTo cells,ganglion
R288 T3787 T3786 _lexicallyChainedTo cells,differentiation of
R275 T3562 T3561 _lexicallyChainedTo proliferation,cell
R280 T3584 T3583 _lexicallyChainedTo cells,horizontal
R282 T3586 T3585 _lexicallyChainedTo cells,bipolar

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3387 2744-2745 CL:0000573 denotes o
T3388 2748-2749 CL:0000745 denotes s
T3389 2745-2748 _FRAGMENT denotes bla
T3390 2748-2749 CL:0000103 denotes s
T3391 2748-2749 CL:0011107 denotes s
T3392 2748-2749 CL:0000561 denotes s
T3374 863-877 CL:0000561 denotes amacrine cells
T3375 887-900 CL:0000740 denotes ganglion cell
T3376 887-906 UBERON:0001792 denotes ganglion cell layer
T3377 908-911 UBERON:0001792 denotes GCL
T3378 930-951 UBERON:0001790 denotes outer plexiform layer
T3379 953-956 UBERON:0001790 denotes OPL
T3380 962-983 UBERON:0001795 denotes inner plexiform layer
T3381 985-988 UBERON:0001795 denotes IPL
T3382 996-1016 GO:0045202 denotes synaptic connections
T3383 1032-1035 UBERON:0001789 denotes ONL
T3384 1036-1039 UBERON:0001791 denotes INL
T3385 1044-1047 UBERON:0001791 denotes INL
T3386 1048-1051 UBERON:0001792 denotes GCL
T3393 2750-2751 UBERON:0000045 denotes o
T3394 2750-2751 _FRAGMENT denotes o
T3417 3187-3197 GO:0007049 denotes cell cycle
T3418 3291-3295 PR:000006852 denotes E2f1
T3419 3297-3301 PR:000006853 denotes E2f2
T3420 3307-3312 PR:000028775 denotes E2f3a
T3421 3357-3367 CL:0000057 denotes fibroblast
T3422 3439-3450 CL:0000057 denotes fibroblasts
T3423 3495-3497 PR:000013773 denotes Rb
T3424 3525-3527 PR:000013773 denotes Rb
T3425 3531-3538 UBERON:0000922 denotes embryos
T3426 3586-3593 UBERON:0000479 denotes tissues
T3427 3610-3614 PR:000006852 denotes E2f1
T3428 3616-3620 PR:000006853 denotes E2f2
T3429 3625-3629 PR:000006854 denotes E2f3
T3430 3675-3677 PR:000013773 denotes Rb
T3431 3735-3739 PR:000006855 denotes E2f4
T3432 3744-3748 PR:000006856 denotes E2f5
T3433 3853-3857 SO:0000704 denotes gene
T3434 3853-3867 GO:0016458 denotes gene silencing
T3435 3871-3880 GO:0044838 denotes quiescent
T3436 3939-3948 GO:0006915 denotes apoptosis
T3437 3956-3958 PR:000013773 denotes Rb
T3438 3962-3968 UBERON:0000966 denotes retina
T3439 3994-3998 PR:000006852 denotes E2f1
T3440 4132-4136 PR:000006852 denotes E2f1
T3441 4140-4144 PR:000006854 denotes E2f3
T3442 4162-4171 GO:0006915 denotes apoptosis
T3443 4190-4212 UBERON:0001017 denotes central nervous system
T3444 4214-4217 UBERON:0001017 denotes CNS
T3445 4222-4224 PR:000013773 denotes Rb
T3446 4228-4235 UBERON:0000922 denotes embryos
T3447 4258-4261 UBERON:0001017 denotes CNS
T3448 4262-4271 GO:0006915 denotes apoptosis
T3449 4310-4319 UBERON:0001987 denotes placental
T3450 4366-4370 PR:000006854 denotes E2f3
T3451 4379-4388 GO:0006915 denotes apoptosis
T3452 4392-4403 CL:0000057 denotes fibroblasts
T3453 4439-4443 PR:000006852 denotes E2f1
T3454 4484-4488 PR:000006854 denotes E2f3
T3455 4505-4514 GO:0006915 denotes apoptosis
T3456 4522-4524 PR:000013773 denotes Rb
T3457 4581-4586 GO:0016265 denotes death
T3458 4599-4601 PR:000013773 denotes Rb
T3459 4605-4612 UBERON:0000479 denotes tissues
T3460 4666-4668 PR:000013773 denotes Rb
T3461 4769-4773 PR:000006854 denotes E2f3
T3462 4774-4782 SO:0001060 denotes isoforms
T3463 4796-4805 SO:0000167 denotes promoters
T3464 4880-4885 SO:0000147 denotes exons
T3465 4892-4897 PR:000028775 denotes E2f3a
T3466 4958-4968 GO:0010467 denotes expression
T3467 4985-4994 GO:0044838 denotes quiescent
T3468 5080-5089 GO:0044838 denotes quiescent
T3469 5117-5126 GO:0044838 denotes quiescent
T3470 5127-5138 CL:0000057 denotes fibroblasts
T3471 5168-5170 PR:000013773 denotes Rb
T3472 5228-5237 GO:0016458 denotes silencing
T3473 5242-5248 PR:000005279 denotes Cdkn2d
T3474 5250-5256 PR:000005279 denotes p19Arf
T3475 5335-5343 SO:0001060 denotes isoforms
T3476 5399-5403 PR:000006852 denotes E2f1
T3477 5408-5412 PR:000006853 denotes E2f2
T3478 5436-5444 SO:0001060 denotes isoforms
T3479 5480-5489 GO:0065007 denotes regulated
T3480 5663-5671 SO:0001060 denotes isoforms
T3481 5735-5737 PR:000013773 denotes Rb
T3482 5752-5760 CL:0000540 denotes neuronal
T3483 5929-5934 GO:0016265 denotes death
T3484 5939-5941 PR:000013773 denotes Rb
T3485 5947-5955 GO:0065007 denotes regulate
T3486 6036-6043 CL:0000540 denotes neurons
T3487 6118-6120 PR:000013773 denotes Rb
T3488 6248-6254 UBERON:0000479 denotes tissue
T3489 6314-6320 UBERON:0000966 denotes retina
T3490 6358-6360 PR:000013773 denotes Rb
T3491 6364-6368 CL:0000604 denotes rods
T3492 6388-6390 PR:000013773 denotes Rb
T3493 6418-6431 GO:0009653 denotes morphogenesis
T3494 6446-6452 UBERON:0000966 denotes retina
T3495 6516-6518 PR:000013773 denotes Rb
T3496 6522-6528 CL:0000540 denotes neuron
T3497 6584-6593 GO:0006915 denotes apoptosis
T3498 6637-6655 _FRAGMENT denotes differentiation of
T3499 6662-6667 GO:0030154 denotes cells
T3500 6656-6658 PR:000013773 denotes Rb
T3501 6694-6707 GO:0008283 denotes proliferation
T3502 6712-6717 GO:0016265 denotes death
T3503 6743-6745 PR:000013773 denotes Rb
T3504 6774-6779 GO:0016265 denotes death
T3505 6794-6798 PR:000006852 denotes E2f1
T3506 6804-6808 PR:000006853 denotes E2f2
T3507 6812-6816 PR:000006854 denotes E2f3
T3508 6856-6863 UBERON:0000966 denotes retinal
T3509 6864-6871 CL:0000540 denotes neurons
T3510 6883-6887 CL:0000604 denotes rods
T3511 6960-6966 UBERON:0000966 denotes retina
T3512 7026-7028 PR:000013773 denotes Rb
T3513 7071-7073 PR:000013773 denotes Rb
T3514 7074-7078 PR:000006852 denotes E2f1
T3515 7099-7105 UBERON:0000966 denotes retina
T3516 7143-7154 CHEBI:15355 denotes cholinergic
T3517 7165-7179 CL:0000561 denotes amacrine cells
T3518 7234-7246 CL:0000099 denotes interneurons
T3519 7431-7433 PR:000013773 denotes Rb
T3520 7483-7489 UBERON:0000479 denotes tissue
T3521 7535-7537 PR:000013773 denotes Rb
T3522 7574-7578 PR:000006854 denotes E2f3
T3523 7591-7593 PR:000013773 denotes Rb
T3524 7629-7633 PR:000006854 denotes E2f3
T3525 7634-7644 GO:0010467 denotes expression
T3526 7665-7669 PR:000006854 denotes E2f3
T3527 7670-7680 GO:0010467 denotes expression
T3528 7695-7702 CL:0000540 denotes neurons
T3529 7731-7733 PR:000013773 denotes Rb
T3530 7735-7739 PR:000006854 denotes E2f3
T3531 7786-7789 UBERON:0001017 denotes CNS
T3532 7786-7797 CL:0000117 denotes CNS neurons
T3533 7854-7856 PR:000013773 denotes Rb
T3534 7869-7881 GO:0022008 denotes neurogenesis
T3535 7948-7952 PR:000006854 denotes E2f3
T3536 7953-7960 SO:0001060 denotes isoform
T3537 7961-7963 PR:000013773 denotes Rb
T3538 7975-7982 GO:0065007 denotes control
T3539 8019-8021 PR:000013773 denotes Rb
T3540 8034-8043 GO:0044838 denotes quiescent
T3541 8044-8055 CL:0000057 denotes fibroblasts
T3542 8115-8120 PR:000028775 denotes E2f3a
T3543 8158-8165 SO:0001060 denotes isoform
T3544 8180-8185 NCBITaxon:10088 denotes mouse
T3545 8199-8201 PR:000013773 denotes Rb
T3546 8237-8242 PR:000028775 denotes E2f3a
T3547 8265-8269 PR:000006852 denotes E2f1
T3548 8303-8308 GO:0016265 denotes death
T3549 8310-8312 PR:000013773 denotes Rb
T3550 8318-8326 GO:0065007 denotes regulate
T3551 8327-8335 CL:0000540 denotes neuronal
T3552 8374-8381 CL:0000540 denotes neurons
T3553 8409-8414 PR:000028775 denotes E2f3a
T3554 8420-8426 UBERON:0000479 denotes tissue
T33323 2112-2119 UBERON:0000966 denotes retinal
T33324 2182-2188 GO:0005634 denotes nuclei
T33325 2190-2194 CHEBI:51231 denotes DAPI
T33326 2211-2218 GO:0051320 denotes S-phase
T33327 2225-2229 CHEBI:472552 denotes BrdU
T33328 2243-2252 GO:0006915 denotes apoptosis
T33269 1077-1081 PR:000006852 denotes E2f1
T33270 1091-1095 PR:000006853 denotes E2f2
T33271 1099-1103 PR:000006854 denotes E2f3
T33272 1139-1149 GO:0008219 denotes Cell Death
T33273 1157-1159 PR:000013773 denotes Rb
T33274 1163-1169 UBERON:0000966 denotes Retina
T33275 1174-1181 UBERON:0000966 denotes Retinal
T33276 1174-1193 GO:0060041 denotes Retinal development
T33277 1206-1212 UBERON:0000966 denotes retina
T33278 1234-1238 CL:0002672 denotes RPCs
T33279 1260-1266 GO:0005634 denotes nuclei
T33280 1269-1272 CL:0002672 denotes RPC
T33281 1273-1284 GO:0044297 denotes cell bodies
T33282 1301-1310 GO:0042995 denotes processes
T33283 1340-1350 GO:0007049 denotes cell cycle
T33284 1380-1384 CL:0002672 denotes RPCs
T33285 1394-1401 GO:0007067 denotes mitotic
T33286 1430-1436 GO:0005634 denotes nuclei
T33287 1464-1467 UBERON:0001792 denotes GCL
T33288 1499-1503 CL:0002672 denotes RPCs
T33289 1549-1553 CL:0000604 denotes rods
T33290 1555-1556 CL:0000604 denotes r
T33291 1562-1567 CL:0000573 denotes cones
T33292 1569-1570 CL:0000573 denotes c
T33293 1579-1582 UBERON:0001789 denotes ONL
T33294 1584-1594 _FRAGMENT denotes horizontal
T33295 1642-1647 CL:0000745 denotes cells
T33296 1596-1597 CL:0000745 denotes h
T33297 1600-1607 _FRAGMENT denotes bipolar
T33298 1642-1647 CL:0000103 denotes cells
T33299 1609-1610 CL:0000103 denotes b
T33300 1613-1619 _FRAGMENT denotes Müller
T33301 1642-1647 CL:0011107 denotes cells
T33302 1621-1622 CL:0011107 denotes m
T33303 1629-1637 _FRAGMENT denotes amacrine
T33304 1642-1647 CL:0000561 denotes cells
T33305 1639-1640 CL:0000561 denotes a
T33306 1655-1658 UBERON:0001791 denotes INL
T33307 1664-1672 UBERON:0000045 denotes ganglion
T33308 1664-1672 _FRAGMENT denotes ganglion
T33309 1700-1705 CL:0000740 denotes cells
T33310 1674-1675 UBERON:0000045 denotes g
T33311 1674-1675 _FRAGMENT denotes g
T33312 1691-1705 CL:0000561 denotes amacrine cells
T33313 1713-1716 UBERON:0001792 denotes GCL
T33314 1755-1757 PR:000013773 denotes Rb
T33315 1772-1780 GO:0065007 denotes regulate
T33316 1781-1791 GO:0007049 denotes cell cycle
T33317 1796-1805 GO:0006915 denotes apoptosis
T33318 1873-1879 UBERON:0000479 denotes tissue
T33319 1921-1923 PR:000013773 denotes Rb
T33320 2017-2022 GO:0016265 denotes death
T33321 2046-2056 GO:0065007 denotes regulation
T33322 2076-2081 SO:0000704 denotes genes
T33329 2321-2325 CHEBI:472552 denotes BrdU
T33330 2346-2350 CHEBI:472552 denotes BrdU
T33331 2361-2364 UBERON:0001792 denotes GCL
T33332 2453-2458 SO:0000704 denotes genes
T33333 2465-2472 UBERON:0000966 denotes retinas
T33334 2552-2559 NCBITaxon:33208 denotes animals
T3341 35-41 UBERON:0000966 denotes retina
T3342 60-66 UBERON:0000479 denotes tissue
T3343 76-88 GO:0022008 denotes neurogenesis
T3344 161-168 UBERON:0000966 denotes retinal
T3345 161-184 CL:0002672 denotes retinal progenitor cell
T3346 180-184 _FRAGMENT denotes cell
T3347 191-204 GO:0008283 denotes proliferation
T3348 186-189 CL:0002672 denotes RPC
T3349 232-239 GO:0007067 denotes mitotic
T3350 240-247 UBERON:0000966 denotes retinal
T3351 389-393 CL:0002672 denotes RPCs
T3352 423-433 GO:0007049 denotes cell cycle
T3353 575-585 GO:0007049 denotes cell cycle
T3354 608-615 GO:0007067 denotes mitotic
T3355 648-662 UBERON:0001781 denotes retinal layers
T3356 664-668 CL:0000604 denotes Rods
T3357 673-678 CL:0000573 denotes cones
T3358 691-710 UBERON:0001789 denotes outer nuclear layer
T3359 697-704 GO:0005634 denotes nuclear
T3360 712-715 UBERON:0001789 denotes ONL
T3361 718-728 _FRAGMENT denotes horizontal
T3362 752-757 CL:0000745 denotes cells
T3363 730-737 _FRAGMENT denotes bipolar
T3364 752-757 CL:0000103 denotes cells
T3365 743-757 CL:0000561 denotes amacrine cells
T3366 770-786 CL:0011107 denotes Müller glia cell
T3367 782-793 GO:0044297 denotes cell bodies
T3368 809-828 UBERON:0001791 denotes inner nuclear layer
T3369 815-822 GO:0005634 denotes nuclear
T3370 830-833 UBERON:0001791 denotes INL
T3371 840-848 UBERON:0000045 denotes ganglion
T3372 840-848 _FRAGMENT denotes ganglion
T3373 872-877 CL:0000740 denotes cells
T3395 2751-2754 CL:0000561 denotes ma
T3396 2755-2756 GO:0065007 denotes r
T3397 2756-2758 GO:0006915 denotes ot
T3398 2767-2770 PR:000013773 denotes is
T3399 2783-2793 GO:0007049 denotes cell cycle
T3400 2806-2813 UBERON:0000966 denotes retinal
T3401 2837-2839 PR:000013773 denotes Rb
T3402 2871-2882 GO:0008283 denotes proliferate
T3403 2909-2912 _FRAGMENT denotes rod
T3404 2936-2941 CL:0000604 denotes cells
T3405 2914-2922 UBERON:0000045 denotes ganglion
T3406 2914-2922 _FRAGMENT denotes ganglion
T3407 2936-2941 CL:0000740 denotes cells
T3408 2928-2941 CL:0000103 denotes bipolar cells
T3409 2943-2946 GO:0016265 denotes die
T3410 2950-2959 GO:0006915 denotes apoptosis
T3411 2967-2969 PR:000013773 denotes Rb
T3412 2970-2978 GO:0065007 denotes controls
T3413 2983-2993 GO:0007049 denotes cell cycle
T3414 3115-3125 NCBITaxon:10508 denotes adenoviral
T3415 3129-3139 GO:0065007 denotes regulatory
T3416 3129-3148 SO:0005836 denotes regulatory elements
R281 T3499 T3498 _lexicallyChainedTo cells,differentiation of
R9929 T33295 T33294 _lexicallyChainedTo cells,horizontal
R9930 T33298 T33297 _lexicallyChainedTo cells,bipolar
R9931 T33301 T33300 _lexicallyChainedTo cells,Müller
R9932 T33304 T33303 _lexicallyChainedTo cells,amacrine
R9933 T33309 T33308 _lexicallyChainedTo cells,ganglion
R9934 T33309 T33311 _lexicallyChainedTo cells,g
R272 T3404 T3403 _lexicallyChainedTo cells,rod
R273 T3347 T3346 _lexicallyChainedTo proliferation,cell
R274 T3407 T3406 _lexicallyChainedTo cells,ganglion
R276 T3362 T3361 _lexicallyChainedTo cells,horizontal
R277 T3364 T3363 _lexicallyChainedTo cells,bipolar
R278 T3373 T3372 _lexicallyChainedTo cells,ganglion
R279 T3390 T3389 _lexicallyChainedTo s,bla

2_test

Id Subject Object Predicate Lexical cue
17608565-15685194-84868941 385-386 15685194 denotes 1
17608565-15685194-84868942 502-503 15685194 denotes 1
17608565-15193257-84868943 2961-2962 15193257 denotes 2
17608565-15231717-84868944 2963-2964 15231717 denotes 3
17608565-12473340-84868945 3210-3211 12473340 denotes 4
17608565-11719808-84868946 3212-3213 11719808 denotes 5
17608565-12473340-84868947 3499-3500 12473340 denotes 4
17608565-11719808-84868948 3501-3502 11719808 denotes 5
17608565-9774968-84868949 3631-3632 9774968 denotes 6
17608565-11146559-84868949 3631-3632 11146559 denotes 6
17608565-11230146-84868949 3631-3632 11230146 denotes 6
17608565-12065245-84868949 3631-3632 12065245 denotes 6
17608565-9207076-84868950 4062-4064 9207076 denotes 10
17608565-9774968-84868951 4237-4238 9774968 denotes 6
17608565-12944480-84868952 4239-4241 12944480 denotes 11
17608565-12607001-84868953 4350-4352 12607001 denotes 12
17608565-12093735-84868953 4350-4352 12093735 denotes 12
17608565-12529408-84868953 4350-4352 12529408 denotes 12
17608565-15976820-84868954 4445-4447 15976820 denotes 15
17608565-10779352-84868955 4887-4889 10779352 denotes 16
17608565-10779352-84868956 5027-5029 10779352 denotes 16
17608565-10779352-84868957 5212-5214 10779352 denotes 16
17608565-10918599-84868957 5212-5214 10918599 denotes 16
17608565-11980909-84868957 5212-5214 11980909 denotes 16
17608565-15175242-84868958 5301-5303 15175242 denotes 19
17608565-10779352-84868959 5414-5416 10779352 denotes 16
17608565-9144196-84868960 5590-5592 9144196 denotes 20
17608565-9271426-84868960 5590-5592 9271426 denotes 20
17608565-9372959-84868960 5590-5592 9372959 denotes 20
17608565-10725332-84868961 5631-5633 10725332 denotes 23
17608565-11161609-84868961 5631-5633 11161609 denotes 23
17608565-15869948-84868961 5631-5633 15869948 denotes 23
17608565-1406933-84868962 5778-5780 1406933 denotes 26
17608565-1406932-84868962 5778-5780 1406932 denotes 26
17608565-7958874-84868962 5778-5780 7958874 denotes 26
17608565-14991054-84868962 5778-5780 14991054 denotes 26
17608565-9420334-84868963 6299-6301 9420334 denotes 30
17608565-8381715-84868963 6299-6301 8381715 denotes 30
17608565-11545733-84868963 6299-6301 11545733 denotes 30
17608565-8946919-84868963 6299-6301 8946919 denotes 30
17608565-14991054-84868964 6471-6473 14991054 denotes 29
17608565-12192402-84868965 7333-7335 12192402 denotes 34
17608565-12459782-84868965 7333-7335 12459782 denotes 34
17608565-16462736-84868965 7333-7335 16462736 denotes 34
17608565-15175242-84868966 8057-8059 15175242 denotes 19
T35231 385-386 15685194 denotes 1
T34771 502-503 15685194 denotes 1
T68391 2961-2962 15193257 denotes 2
T52784 2963-2964 15231717 denotes 3
T97361 3210-3211 12473340 denotes 4
T36661 3212-3213 11719808 denotes 5
T48203 3499-3500 12473340 denotes 4
T21588 3501-3502 11719808 denotes 5
T16930 3631-3632 9774968 denotes 6
T99767 3631-3632 11146559 denotes 6
T79985 3631-3632 11230146 denotes 6
T2705 3631-3632 12065245 denotes 6
T38996 4062-4064 9207076 denotes 10
T39364 4237-4238 9774968 denotes 6
T81130 4239-4241 12944480 denotes 11
T45376 4350-4352 12607001 denotes 12
T63014 4350-4352 12093735 denotes 12
T12410 4350-4352 12529408 denotes 12
T63844 4445-4447 15976820 denotes 15
T84824 4887-4889 10779352 denotes 16
T79039 5027-5029 10779352 denotes 16
T95919 5212-5214 10779352 denotes 16
T65602 5212-5214 10918599 denotes 16
T57559 5212-5214 11980909 denotes 16
T82499 5301-5303 15175242 denotes 19
T54228 5414-5416 10779352 denotes 16
T87306 5590-5592 9144196 denotes 20
T26615 5590-5592 9271426 denotes 20
T85550 5590-5592 9372959 denotes 20
T94086 5631-5633 10725332 denotes 23
T67804 5631-5633 11161609 denotes 23
T13311 5631-5633 15869948 denotes 23
T28488 5778-5780 1406933 denotes 26
T94522 5778-5780 1406932 denotes 26
T38375 5778-5780 7958874 denotes 26
T411 5778-5780 14991054 denotes 26
T42910 6299-6301 9420334 denotes 30
T60785 6299-6301 8381715 denotes 30
T17937 6299-6301 11545733 denotes 30
T32658 6299-6301 8946919 denotes 30
T89272 6471-6473 14991054 denotes 29
T13691 7333-7335 12192402 denotes 34
T43454 7333-7335 12459782 denotes 34
T66684 7333-7335 16462736 denotes 34
T39215 8057-8059 15175242 denotes 19