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PMC:1914394 / 29574-31087 JSONTXT

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Id Subject Object Predicate Lexical cue
T16401 0-2 NN denotes Rb
T16402 3-8 VBZ denotes binds
T16403 9-13 JJR denotes more
T16404 19-22 CD denotes 100
T16405 14-18 IN denotes than
T16406 23-31 NN denotes proteins
T16407 32-33 -LRB- denotes [
T16408 33-35 CD denotes 43
T16409 35-36 -RRB- denotes ]
T16410 37-40 CC denotes and
T16411 41-43 IN denotes in
T16412 122-129 VBN denotes thought
T16413 44-48 DT denotes some
T16414 62-67 NNS denotes cells
T16415 49-61 JJ denotes non-neuronal
T16416 67-69 , denotes ,
T16417 69-73 JJ denotes such
T16418 74-76 IN denotes as
T16419 77-85 JJ denotes skeletal
T16420 86-92 NN denotes muscle
T16421 92-94 , denotes ,
T16422 94-104 NNS denotes adipocytes
T16423 104-106 , denotes ,
T16424 106-109 CC denotes and
T16425 110-114 NN denotes bone
T16426 114-116 , denotes ,
T16427 116-118 NN denotes Rb
T16428 119-121 VBZ denotes is
T16429 130-132 TO denotes to
T16430 133-137 VB denotes bind
T16431 138-141 CC denotes and
T16432 142-152 VB denotes potentiate
T16433 153-159 NN denotes tissue
T16434 160-168 JJ denotes specific
T16435 159-160 HYPH denotes -
T16436 183-190 NNS denotes factors
T16437 169-182 NN denotes transcription
T16438 191-195 WDT denotes that
T16439 196-203 VBP denotes promote
T16440 204-219 NN denotes differentiation
T16441 220-221 -LRB- denotes [
T16442 221-223 CD denotes 31
T16443 223-224 SYM denotes –
T16444 224-226 CD denotes 33
T16445 226-227 -RRB- denotes ]
T16446 227-228 . denotes .
T16447 228-333 sentence denotes Thus, we expected that Rb might interact with retina-specific factors to facilitate SAC differentiation.
T16448 229-233 RB denotes Thus
T16449 238-246 VBD denotes expected
T16450 233-235 , denotes ,
T16451 235-237 PRP denotes we
T16452 247-251 IN denotes that
T16453 261-269 VB denotes interact
T16454 252-254 NN denotes Rb
T16455 255-260 MD denotes might
T16456 270-274 IN denotes with
T16457 275-281 NN denotes retina
T16458 282-290 JJ denotes specific
T16459 281-282 HYPH denotes -
T16460 291-298 NNS denotes factors
T16461 299-301 TO denotes to
T16462 302-312 VB denotes facilitate
T16463 313-316 NN denotes SAC
T16464 317-332 NN denotes differentiation
T16465 332-333 . denotes .
T16466 333-629 sentence denotes A direct role for E2f in mediating Rb-dependent differentiation defects (independent of cell cycle or death defects) has to our knowledge not been described, but because E2f can regulate some differentiation genes [44–48], we first tested whether E2f2 or E2f3 might perturb Rb KO SAC maturation.
T16467 334-335 DT denotes A
T16468 343-347 NN denotes role
T16469 336-342 JJ denotes direct
T16470 481-490 VBN denotes described
T16471 348-351 IN denotes for
T16472 352-355 NN denotes E2f
T16473 356-358 IN denotes in
T16474 359-368 VBG denotes mediating
T16475 369-371 NN denotes Rb
T16476 372-381 JJ denotes dependent
T16477 371-372 HYPH denotes -
T16478 398-405 NNS denotes defects
T16479 382-397 NN denotes differentiation
T16480 406-407 -LRB- denotes (
T16481 407-418 JJ denotes independent
T16482 419-421 IN denotes of
T16483 422-426 NN denotes cell
T16484 427-432 NN denotes cycle
T16485 442-449 NNS denotes defects
T16486 433-435 CC denotes or
T16487 436-441 NN denotes death
T16488 449-450 -RRB- denotes )
T16489 451-454 VBZ denotes has
T16490 455-457 IN denotes to
T16491 458-461 PRP$ denotes our
T16492 462-471 NN denotes knowledge
T16493 472-475 RB denotes not
T16494 476-480 VBN denotes been
T16495 490-492 , denotes ,
T16496 492-495 CC denotes but
T16497 496-503 IN denotes because
T16498 512-520 VB denotes regulate
T16499 504-507 NN denotes E2f
T16500 508-511 MD denotes can
T16501 566-572 VBD denotes tested
T16502 521-525 DT denotes some
T16503 542-547 NNS denotes genes
T16504 526-541 NN denotes differentiation
T16505 548-549 -LRB- denotes [
T16506 549-551 CD denotes 44
T16507 551-552 SYM denotes –
T16508 552-554 CD denotes 48
T16509 554-555 -RRB- denotes ]
T16510 555-557 , denotes ,
T16511 557-559 PRP denotes we
T16512 560-565 RB denotes first
T16513 573-580 IN denotes whether
T16514 600-607 VB denotes perturb
T16515 581-585 NN denotes E2f2
T16516 586-588 CC denotes or
T16517 589-593 NN denotes E2f3
T16518 594-599 MD denotes might
T16519 608-610 NN denotes Rb
T16520 611-613 NN denotes KO
T16521 614-617 NN denotes SAC
T16522 618-628 NN denotes maturation
T16523 628-629 . denotes .
T16524 629-807 sentence denotes At multiple time points, E2f1 deletion suppressed ectopic mitosis (PH3+ cells), but did not reverse the SAC defect, and E2f2 deletion had no effect on either defect (Figure 4A).
T16525 630-632 IN denotes At
T16526 669-679 VBD denotes suppressed
T16527 633-641 JJ denotes multiple
T16528 647-653 NNS denotes points
T16529 642-646 NN denotes time
T16530 653-655 , denotes ,
T16531 655-659 NN denotes E2f1
T16532 660-668 NN denotes deletion
T16533 680-687 JJ denotes ectopic
T16534 688-695 NN denotes mitosis
T16535 696-697 -LRB- denotes (
T16536 702-707 NNS denotes cells
T16537 697-700 NN denotes PH3
T16538 700-701 SYM denotes +
T16539 707-708 -RRB- denotes )
T16540 708-710 , denotes ,
T16541 710-713 CC denotes but
T16542 714-717 VBD denotes did
T16543 722-729 VB denotes reverse
T16544 718-721 RB denotes not
T16545 730-733 DT denotes the
T16546 738-744 NN denotes defect
T16547 734-737 NN denotes SAC
T16548 744-746 , denotes ,
T16549 746-749 CC denotes and
T16550 750-754 NN denotes E2f2
T16551 755-763 NN denotes deletion
T16552 764-767 VBD denotes had
T16553 768-770 DT denotes no
T16554 771-777 NN denotes effect
T16555 778-780 IN denotes on
T16556 781-787 CC denotes either
T16557 788-794 NN denotes defect
T16558 795-796 -LRB- denotes (
T16559 803-805 NN denotes 4A
T16560 796-802 NN denotes Figure
T16561 805-806 -RRB- denotes )
T16562 806-807 . denotes .
T16563 807-997 sentence denotes Remarkably, although E2f3 deletion did not reverse ectopic mitosis, it rescued Calb2, Slc18a3, Chat, GABA, Kcnc1b, Kcnc2, and Sv2c staining at multiple times (Figure 4A and data not shown).
T16564 808-818 RB denotes Remarkably
T16565 879-886 VBD denotes rescued
T16566 818-820 , denotes ,
T16567 820-828 IN denotes although
T16568 851-858 VB denotes reverse
T16569 829-833 NN denotes E2f3
T16570 834-842 NN denotes deletion
T16571 843-846 VBD denotes did
T16572 847-850 RB denotes not
T16573 859-866 JJ denotes ectopic
T16574 867-874 NN denotes mitosis
T16575 874-876 , denotes ,
T16576 876-878 PRP denotes it
T16577 887-892 NN denotes Calb2
T16578 939-947 NN denotes staining
T16579 892-894 , denotes ,
T16580 894-901 NN denotes Slc18a3
T16581 901-903 , denotes ,
T16582 903-907 NN denotes Chat
T16583 907-909 , denotes ,
T16584 909-913 NN denotes GABA
T16585 913-915 , denotes ,
T16586 915-921 NN denotes Kcnc1b
T16587 921-923 , denotes ,
T16588 923-928 NN denotes Kcnc2
T16589 928-930 , denotes ,
T16590 930-933 CC denotes and
T16591 934-938 NN denotes Sv2c
T16592 948-950 IN denotes at
T16593 951-959 JJ denotes multiple
T16594 960-965 NNS denotes times
T16595 966-967 -LRB- denotes (
T16596 974-976 NN denotes 4A
T16597 967-973 NN denotes Figure
T16598 977-980 CC denotes and
T16599 981-985 NNS denotes data
T16600 990-995 VBN denotes shown
T16601 986-989 RB denotes not
T16602 995-996 -RRB- denotes )
T16603 996-997 . denotes .
T16604 997-1157 sentence denotes Rb/E2f3 DKO SAC tracks were slightly more disordered than in WT retina, most likely because of the absence of synaptic partner cells, which are killed by E2f1.
T16605 998-1000 NN denotes Rb
T16606 1001-1005 NN denotes E2f3
T16607 1000-1001 HYPH denotes /
T16608 1006-1009 NN denotes DKO
T16609 1010-1013 NN denotes SAC
T16610 1014-1020 NNS denotes tracks
T16611 1021-1025 VBD denotes were
T16612 1026-1034 RB denotes slightly
T16613 1035-1039 RBR denotes more
T16614 1040-1050 VBN denotes disordered
T16615 1051-1055 IN denotes than
T16616 1056-1058 IN denotes in
T16617 1059-1061 NN denotes WT
T16618 1062-1068 NN denotes retina
T16619 1068-1070 , denotes ,
T16620 1070-1074 RBS denotes most
T16621 1075-1081 RB denotes likely
T16622 1082-1089 IN denotes because
T16623 1090-1092 IN denotes of
T16624 1093-1096 DT denotes the
T16625 1097-1104 NN denotes absence
T16626 1105-1107 IN denotes of
T16627 1108-1116 JJ denotes synaptic
T16628 1125-1130 NNS denotes cells
T16629 1117-1124 NN denotes partner
T16630 1130-1132 , denotes ,
T16631 1132-1137 WDT denotes which
T16632 1142-1148 VBN denotes killed
T16633 1138-1141 VBP denotes are
T16634 1149-1151 IN denotes by
T16635 1152-1156 NN denotes E2f1
T16636 1156-1157 . denotes .
T16637 1157-1339 sentence denotes Indeed, this minor defect was rescued in the Rb/E2f1/E2f3 triple knockout retina, where bipolar and ganglion cell death was rescued and SAC differentiation was restored (Figure 4A).
T16638 1158-1164 RB denotes Indeed
T16639 1188-1195 VBN denotes rescued
T16640 1164-1166 , denotes ,
T16641 1166-1170 DT denotes this
T16642 1177-1183 NN denotes defect
T16643 1171-1176 JJ denotes minor
T16644 1184-1187 VBD denotes was
T16645 1196-1198 IN denotes in
T16646 1199-1202 DT denotes the
T16647 1232-1238 NN denotes retina
T16648 1203-1205 NN denotes Rb
T16649 1211-1215 NN denotes E2f3
T16650 1205-1206 HYPH denotes /
T16651 1206-1210 NN denotes E2f1
T16652 1210-1211 HYPH denotes /
T16653 1223-1231 NN denotes knockout
T16654 1216-1222 JJ denotes triple
T16655 1238-1240 , denotes ,
T16656 1240-1245 WRB denotes where
T16657 1282-1289 VBN denotes rescued
T16658 1246-1253 JJ denotes bipolar
T16659 1267-1271 NN denotes cell
T16660 1254-1257 CC denotes and
T16661 1258-1266 NN denotes ganglion
T16662 1272-1277 NN denotes death
T16663 1278-1281 VBD denotes was
T16664 1290-1293 CC denotes and
T16665 1294-1297 NN denotes SAC
T16666 1298-1313 NN denotes differentiation
T16667 1318-1326 VBN denotes restored
T16668 1314-1317 VBD denotes was
T16669 1327-1328 -LRB- denotes (
T16670 1335-1337 NN denotes 4A
T16671 1328-1334 NN denotes Figure
T16672 1337-1338 -RRB- denotes )
T16673 1338-1339 . denotes .
T16674 1339-1513 sentence denotes E2f3 deletion alone did not affect SAC differentiation (Figure 4A); thus, it is unleashed E2f3 activity that is detrimental, and the critical role for Rb is to inhibit E2f3.
T16675 1340-1344 NN denotes E2f3
T16676 1345-1353 NN denotes deletion
T16677 1368-1374 VB denotes affect
T16678 1354-1359 RB denotes alone
T16679 1360-1363 VBD denotes did
T16680 1364-1367 RB denotes not
T16681 1375-1378 NN denotes SAC
T16682 1379-1394 NN denotes differentiation
T16683 1395-1396 -LRB- denotes (
T16684 1403-1405 NN denotes 4A
T16685 1396-1402 NN denotes Figure
T16686 1405-1406 -RRB- denotes )
T16687 1406-1407 : denotes ;
T16688 1408-1412 RB denotes thus
T16689 1417-1419 VBZ denotes is
T16690 1412-1414 , denotes ,
T16691 1414-1416 PRP denotes it
T16692 1420-1429 VBN denotes unleashed
T16693 1435-1443 NN denotes activity
T16694 1430-1434 NN denotes E2f3
T16695 1444-1448 WDT denotes that
T16696 1449-1451 VBZ denotes is
T16697 1452-1463 JJ denotes detrimental
T16698 1463-1465 , denotes ,
T16699 1465-1468 CC denotes and
T16700 1469-1472 DT denotes the
T16701 1482-1486 NN denotes role
T16702 1473-1481 JJ denotes critical
T16703 1494-1496 VBZ denotes is
T16704 1487-1490 IN denotes for
T16705 1491-1493 NN denotes Rb
T16706 1497-1499 TO denotes to
T16707 1500-1507 VB denotes inhibit
T16708 1508-1512 NN denotes E2f3
T16709 1512-1513 . denotes .
R4458 T16401 T16402 nsubj Rb,binds
R4459 T16403 T16404 amod more,100
R4460 T16404 T16406 nummod 100,proteins
R4461 T16405 T16404 quantmod than,100
R4462 T16406 T16402 dobj proteins,binds
R4463 T16407 T16408 punct [,43
R4464 T16408 T16402 parataxis 43,binds
R4465 T16409 T16408 punct ],43
R4466 T16410 T16402 cc and,binds
R4467 T16411 T16412 prep in,thought
R4468 T16412 T16402 conj thought,binds
R4469 T16413 T16414 det some,cells
R4470 T16414 T16411 pobj cells,in
R4471 T16415 T16414 amod non-neuronal,cells
R4472 T16416 T16414 punct ", ",cells
R4473 T16417 T16418 amod such,as
R4474 T16418 T16414 prep as,cells
R4475 T16419 T16420 amod skeletal,muscle
R4476 T16420 T16418 pobj muscle,as
R4477 T16421 T16420 punct ", ",muscle
R4478 T16422 T16420 conj adipocytes,muscle
R4479 T16423 T16422 punct ", ",adipocytes
R4480 T16424 T16422 cc and,adipocytes
R4481 T16425 T16422 conj bone,adipocytes
R4482 T16426 T16412 punct ", ",thought
R4483 T16427 T16412 nsubjpass Rb,thought
R4484 T16428 T16412 auxpass is,thought
R4485 T16429 T16430 aux to,bind
R4486 T16430 T16412 xcomp bind,thought
R4487 T16431 T16430 cc and,bind
R4488 T16432 T16430 conj potentiate,bind
R4489 T16433 T16434 npadvmod tissue,specific
R4490 T16434 T16436 amod specific,factors
R4491 T16435 T16434 punct -,specific
R4492 T16436 T16432 dobj factors,potentiate
R4493 T16437 T16436 compound transcription,factors
R4494 T16438 T16439 dep that,promote
R4495 T16439 T16436 relcl promote,factors
R4496 T16440 T16439 dobj differentiation,promote
R4497 T16441 T16442 punct [,31
R4498 T16442 T16432 parataxis 31,potentiate
R4499 T16443 T16444 punct –,33
R4500 T16444 T16442 prep 33,31
R4501 T16445 T16442 punct ],31
R4502 T16446 T16412 punct .,thought
R4503 T16448 T16449 advmod Thus,expected
R4504 T16450 T16449 punct ", ",expected
R4505 T16451 T16449 nsubj we,expected
R4506 T16452 T16453 mark that,interact
R4507 T16453 T16449 ccomp interact,expected
R4508 T16454 T16453 nsubj Rb,interact
R4509 T16455 T16453 aux might,interact
R4510 T16456 T16453 prep with,interact
R4511 T16457 T16458 npadvmod retina,specific
R4512 T16458 T16460 amod specific,factors
R4513 T16459 T16458 punct -,specific
R4514 T16460 T16456 pobj factors,with
R4515 T16461 T16462 aux to,facilitate
R4516 T16462 T16453 advcl facilitate,interact
R4517 T16463 T16464 compound SAC,differentiation
R4518 T16464 T16462 dobj differentiation,facilitate
R4519 T16465 T16449 punct .,expected
R4520 T16467 T16468 det A,role
R4521 T16468 T16470 nsubjpass role,described
R4522 T16469 T16468 amod direct,role
R4523 T16471 T16468 prep for,role
R4524 T16472 T16471 pobj E2f,for
R4525 T16473 T16468 prep in,role
R4526 T16474 T16473 pcomp mediating,in
R4527 T16475 T16476 npadvmod Rb,dependent
R4528 T16476 T16478 amod dependent,defects
R4529 T16477 T16476 punct -,dependent
R4530 T16478 T16474 dobj defects,mediating
R4531 T16479 T16478 compound differentiation,defects
R4532 T16480 T16478 punct (,defects
R4533 T16481 T16478 amod independent,defects
R4534 T16482 T16481 prep of,independent
R4535 T16483 T16484 nmod cell,cycle
R4536 T16484 T16485 nmod cycle,defects
R4537 T16485 T16482 pobj defects,of
R4538 T16486 T16484 cc or,cycle
R4539 T16487 T16484 conj death,cycle
R4540 T16488 T16470 punct ),described
R4541 T16489 T16470 aux has,described
R4542 T16490 T16470 prep to,described
R4543 T16491 T16492 poss our,knowledge
R4544 T16492 T16490 pobj knowledge,to
R4545 T16493 T16470 neg not,described
R4546 T16494 T16470 auxpass been,described
R4547 T16495 T16470 punct ", ",described
R4548 T16496 T16470 cc but,described
R4549 T16497 T16498 mark because,regulate
R4550 T16498 T16501 advcl regulate,tested
R4551 T16499 T16498 nsubj E2f,regulate
R4552 T16500 T16498 aux can,regulate
R4553 T16501 T16470 conj tested,described
R4554 T16502 T16503 det some,genes
R4555 T16503 T16498 dobj genes,regulate
R4556 T16504 T16503 compound differentiation,genes
R4557 T16505 T16506 punct [,44
R4558 T16506 T16498 parataxis 44,regulate
R4559 T16507 T16508 punct –,48
R4560 T16508 T16506 prep 48,44
R4561 T16509 T16506 punct ],44
R4562 T16510 T16501 punct ", ",tested
R4563 T16511 T16501 nsubj we,tested
R4564 T16512 T16501 advmod first,tested
R4565 T16513 T16514 mark whether,perturb
R4566 T16514 T16501 ccomp perturb,tested
R4567 T16515 T16514 nsubj E2f2,perturb
R4568 T16516 T16515 cc or,E2f2
R4569 T16517 T16515 conj E2f3,E2f2
R4570 T16518 T16514 aux might,perturb
R4571 T16519 T16520 compound Rb,KO
R4572 T16520 T16521 compound KO,SAC
R4573 T16521 T16522 compound SAC,maturation
R4574 T16522 T16514 dobj maturation,perturb
R4575 T16523 T16501 punct .,tested
R4576 T16525 T16526 prep At,suppressed
R4577 T16527 T16528 amod multiple,points
R4578 T16528 T16525 pobj points,At
R4579 T16529 T16528 compound time,points
R4580 T16530 T16526 punct ", ",suppressed
R4581 T16531 T16532 compound E2f1,deletion
R4582 T16532 T16526 nsubj deletion,suppressed
R4583 T16533 T16534 amod ectopic,mitosis
R4584 T16534 T16526 dobj mitosis,suppressed
R4585 T16535 T16536 punct (,cells
R4586 T16536 T16526 parataxis cells,suppressed
R4587 T16537 T16536 nmod PH3,cells
R4588 T16538 T16537 punct +,PH3
R4589 T16539 T16536 punct ),cells
R4590 T16540 T16526 punct ", ",suppressed
R4591 T16541 T16526 cc but,suppressed
R4592 T16542 T16543 aux did,reverse
R4593 T16543 T16526 conj reverse,suppressed
R4594 T16544 T16543 neg not,reverse
R4595 T16545 T16546 det the,defect
R4596 T16546 T16543 dobj defect,reverse
R4597 T16547 T16546 compound SAC,defect
R4598 T16548 T16526 punct ", ",suppressed
R4599 T16549 T16526 cc and,suppressed
R4600 T16550 T16551 compound E2f2,deletion
R4601 T16551 T16552 nsubj deletion,had
R4602 T16552 T16526 conj had,suppressed
R4603 T16553 T16554 det no,effect
R4604 T16554 T16552 dobj effect,had
R4605 T16555 T16554 prep on,effect
R4606 T16556 T16557 preconj either,defect
R4607 T16557 T16555 pobj defect,on
R4608 T16558 T16559 punct (,4A
R4609 T16559 T16552 parataxis 4A,had
R4610 T16560 T16559 compound Figure,4A
R4611 T16561 T16559 punct ),4A
R4612 T16562 T16552 punct .,had
R4613 T16564 T16565 advmod Remarkably,rescued
R4614 T16566 T16565 punct ", ",rescued
R4615 T16567 T16568 mark although,reverse
R4616 T16568 T16565 advcl reverse,rescued
R4617 T16569 T16570 compound E2f3,deletion
R4618 T16570 T16568 nsubj deletion,reverse
R4619 T16571 T16568 aux did,reverse
R4620 T16572 T16568 neg not,reverse
R4621 T16573 T16574 amod ectopic,mitosis
R4622 T16574 T16568 dobj mitosis,reverse
R4623 T16575 T16565 punct ", ",rescued
R4624 T16576 T16565 nsubj it,rescued
R4625 T16577 T16578 nmod Calb2,staining
R4626 T16578 T16565 dobj staining,rescued
R4627 T16579 T16577 punct ", ",Calb2
R4628 T16580 T16577 conj Slc18a3,Calb2
R4629 T16581 T16580 punct ", ",Slc18a3
R4630 T16582 T16580 conj Chat,Slc18a3
R4631 T16583 T16582 punct ", ",Chat
R4632 T16584 T16582 conj GABA,Chat
R4633 T16585 T16584 punct ", ",GABA
R4634 T16586 T16584 conj Kcnc1b,GABA
R4635 T16587 T16586 punct ", ",Kcnc1b
R4636 T16588 T16586 conj Kcnc2,Kcnc1b
R4637 T16589 T16588 punct ", ",Kcnc2
R4638 T16590 T16588 cc and,Kcnc2
R4639 T16591 T16588 conj Sv2c,Kcnc2
R4640 T16592 T16565 prep at,rescued
R4641 T16593 T16594 amod multiple,times
R4642 T16594 T16592 pobj times,at
R4643 T16595 T16596 punct (,4A
R4644 T16596 T16565 parataxis 4A,rescued
R4645 T16597 T16596 compound Figure,4A
R4646 T16598 T16596 cc and,4A
R4647 T16599 T16600 nsubj data,shown
R4648 T16600 T16596 conj shown,4A
R4649 T16601 T16600 neg not,shown
R4650 T16602 T16600 punct ),shown
R4651 T16603 T16565 punct .,rescued
R4652 T16605 T16606 compound Rb,E2f3
R4653 T16606 T16608 compound E2f3,DKO
R4654 T16607 T16606 punct /,E2f3
R4655 T16608 T16609 compound DKO,SAC
R4656 T16609 T16610 compound SAC,tracks
R4657 T16610 T16611 nsubj tracks,were
R4658 T16612 T16613 advmod slightly,more
R4659 T16613 T16614 advmod more,disordered
R4660 T16614 T16611 acomp disordered,were
R4661 T16615 T16614 prep than,disordered
R4662 T16616 T16615 prep in,than
R4663 T16617 T16618 compound WT,retina
R4664 T16618 T16616 pobj retina,in
R4665 T16619 T16611 punct ", ",were
R4666 T16620 T16621 advmod most,likely
R4667 T16621 T16622 advmod likely,because
R4668 T16622 T16611 prep because,were
R4669 T16623 T16622 pcomp of,because
R4670 T16624 T16625 det the,absence
R4671 T16625 T16622 pobj absence,because
R4672 T16626 T16625 prep of,absence
R4673 T16627 T16628 amod synaptic,cells
R4674 T16628 T16626 pobj cells,of
R4675 T16629 T16628 compound partner,cells
R4676 T16630 T16628 punct ", ",cells
R4677 T16631 T16632 dep which,killed
R4678 T16632 T16628 relcl killed,cells
R4679 T16633 T16632 auxpass are,killed
R4680 T16634 T16632 agent by,killed
R4681 T16635 T16634 pobj E2f1,by
R4682 T16636 T16611 punct .,were
R4683 T16638 T16639 advmod Indeed,rescued
R4684 T16640 T16639 punct ", ",rescued
R4685 T16641 T16642 det this,defect
R4686 T16642 T16639 nsubjpass defect,rescued
R4687 T16643 T16642 amod minor,defect
R4688 T16644 T16639 auxpass was,rescued
R4689 T16645 T16639 prep in,rescued
R4690 T16646 T16647 det the,retina
R4691 T16647 T16645 pobj retina,in
R4692 T16648 T16649 nmod Rb,E2f3
R4693 T16649 T16653 nmod E2f3,knockout
R4694 T16650 T16649 punct /,E2f3
R4695 T16651 T16649 nmod E2f1,E2f3
R4696 T16652 T16649 punct /,E2f3
R4697 T16653 T16647 compound knockout,retina
R4698 T16654 T16653 amod triple,knockout
R4699 T16655 T16647 punct ", ",retina
R4700 T16656 T16657 advmod where,rescued
R4701 T16657 T16647 relcl rescued,retina
R4702 T16658 T16659 amod bipolar,cell
R4703 T16659 T16662 compound cell,death
R4704 T16660 T16658 cc and,bipolar
R4705 T16661 T16658 conj ganglion,bipolar
R4706 T16662 T16657 nsubjpass death,rescued
R4707 T16663 T16657 auxpass was,rescued
R4708 T16664 T16657 cc and,rescued
R4709 T16665 T16666 compound SAC,differentiation
R4710 T16666 T16667 nsubjpass differentiation,restored
R4711 T16667 T16657 conj restored,rescued
R4712 T16668 T16667 auxpass was,restored
R4713 T16669 T16670 punct (,4A
R4714 T16670 T16639 parataxis 4A,rescued
R4715 T16671 T16670 compound Figure,4A
R4716 T16672 T16670 punct ),4A
R4717 T16673 T16639 punct .,rescued
R4718 T16675 T16676 compound E2f3,deletion
R4719 T16676 T16677 nsubj deletion,affect
R4720 T16678 T16676 advmod alone,deletion
R4721 T16679 T16677 aux did,affect
R4722 T16680 T16677 neg not,affect
R4723 T16681 T16682 compound SAC,differentiation
R4724 T16682 T16677 dobj differentiation,affect
R4725 T16683 T16684 punct (,4A
R4726 T16684 T16677 parataxis 4A,affect
R4727 T16685 T16684 compound Figure,4A
R4728 T16686 T16684 punct ),4A
R4729 T16687 T16677 punct ;,affect
R4730 T16688 T16689 advmod thus,is
R4731 T16689 T16677 conj is,affect
R4732 T16690 T16689 punct ", ",is
R4733 T16691 T16689 nsubj it,is
R4734 T16692 T16693 amod unleashed,activity
R4735 T16693 T16689 attr activity,is
R4736 T16694 T16693 compound E2f3,activity
R4737 T16695 T16696 dep that,is
R4738 T16696 T16689 ccomp is,is
R4739 T16697 T16696 acomp detrimental,is
R4740 T16698 T16689 punct ", ",is
R4741 T16699 T16689 cc and,is
R4742 T16700 T16701 det the,role
R4743 T16701 T16703 nsubj role,is
R4744 T16702 T16701 amod critical,role
R4745 T16703 T16689 conj is,is
R4746 T16704 T16701 prep for,role
R4747 T16705 T16704 pobj Rb,for
R4748 T16706 T16707 aux to,inhibit
R4749 T16707 T16703 xcomp inhibit,is
R4750 T16708 T16707 dobj E2f3,inhibit
R4751 T16709 T16703 punct .,is

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T16232 0-2 PR_EXT:000013773 denotes Rb
T16233 3-8 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T16234 23-31 CHEBI_PR_EXT:protein denotes proteins
T16235 53-61 CL:0000540 denotes neuronal
T16236 62-67 CL_GO_EXT:cell denotes cells
T16237 77-92 UBERON_EXT:skeletal_muscle_organ_or_tissue denotes skeletal muscle
T16238 94-104 CL:0000136 denotes adipocytes
T16239 110-114 UBERON_EXT:bone_element_or_tissue denotes bone
T16240 116-118 PR_EXT:000013773 denotes Rb
T16241 133-137 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T16242 153-159 UBERON:0000479 denotes tissue
T16243 169-182 GO_EXT:transcription denotes transcription
T16244 169-190 GO_EXT:transcription_factor denotes transcription factors
T16245 204-219 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16246 252-254 PR_EXT:000013773 denotes Rb
T16247 275-281 UBERON:0000966 denotes retina
T16248 317-332 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16249 352-355 PR_EXT:E2F denotes E2f
T16250 369-371 PR_EXT:000013773 denotes Rb
T16251 382-397 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16252 422-426 CL_GO_EXT:cell denotes cell
T16253 422-432 GO:0007049 denotes cell cycle
T16254 422-426 _FRAGMENT denotes cell
T16255 436-441 GO:0008219 denotes death
T16256 504-507 PR_EXT:E2F denotes E2f
T16257 512-520 GO:0065007 denotes regulate
T16258 526-541 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16259 542-547 SO_EXT:0000704 denotes genes
T16260 581-585 PR_EXT:000006853 denotes E2f2
T16261 589-593 PR_EXT:000006854 denotes E2f3
T16262 608-610 PR_EXT:000013773 denotes Rb
T16263 618-628 GO_PATO_EXT:biological_maturation denotes maturation
T16264 655-659 PR_EXT:000006852 denotes E2f1
T16265 660-668 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T16266 688-695 GO:0007067 denotes mitosis
T16267 702-707 CL_GO_EXT:cell denotes cells
T16268 750-754 PR_EXT:000006853 denotes E2f2
T16269 755-763 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T16270 829-833 PR_EXT:000006854 denotes E2f3
T16271 834-842 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T16272 867-874 GO:0007067 denotes mitosis
T16273 879-886 SO_EXT:sequence_rescue_process denotes rescued
T16274 887-892 PR_EXT:000004968 denotes Calb2
T16275 894-901 PR_EXT:000014968 denotes Slc18a3
T16276 903-907 GO_PR_EXT:choline_O_acetyltransferase denotes Chat
T16277 909-913 CHEBI:16865 denotes GABA
T16278 915-921 PR_EXT:000000940 denotes Kcnc1b
T16279 923-928 PR_EXT:000000782 denotes Kcnc2
T16280 934-938 PR_EXT:000015851 denotes Sv2c
T16281 998-1000 PR_EXT:000013773 denotes Rb
T16282 1001-1005 PR_EXT:000006854 denotes E2f3
T16283 1059-1061 SO_EXT:wild_type_entity_or_quality denotes WT
T16284 1062-1068 UBERON:0000966 denotes retina
T16285 1108-1116 GO:0045202 denotes synaptic
T16286 1125-1130 CL_GO_EXT:cell denotes cells
T16287 1142-1148 GO_EXT:killing denotes killed
T16288 1152-1156 PR_EXT:000006852 denotes E2f1
T16289 1188-1195 SO_EXT:sequence_rescue_process denotes rescued
T16290 1203-1205 PR_EXT:000013773 denotes Rb
T16291 1206-1210 PR_EXT:000006852 denotes E2f1
T16292 1211-1215 PR_EXT:000006854 denotes E2f3
T16293 1232-1238 UBERON:0000966 denotes retina
T16294 1246-1253 _FRAGMENT denotes bipolar
T16295 1267-1271 CL:0000103 denotes cell
T16296 1258-1266 UBERON:0000045 denotes ganglion
T16297 1258-1271 CL:0000740 denotes ganglion cell
T16298 1267-1271 CL_GO_EXT:cell denotes cell
T16299 1267-1277 GO:0008219 denotes cell death
T16300 1282-1289 SO_EXT:sequence_rescue_process denotes rescued
T16301 1298-1313 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16302 1340-1344 PR_EXT:000006854 denotes E2f3
T16303 1345-1353 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T16304 1379-1394 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16305 1430-1434 PR_EXT:000006854 denotes E2f3
T16306 1491-1493 PR_EXT:000013773 denotes Rb
T16307 1508-1512 PR_EXT:000006854 denotes E2f3
R4451 T16255 T16254 _lexicallyChainedTo death,cell
R4452 T16295 T16294 _lexicallyChainedTo cell,bipolar

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T16158 1211-1215 PR:000006854 denotes E2f3
T16159 1232-1238 UBERON:0000966 denotes retina
T16160 1246-1253 _FRAGMENT denotes bipolar
T16161 1267-1271 CL:0000103 denotes cell
T16162 1258-1266 UBERON:0000045 denotes ganglion
T16163 1258-1271 CL:0000740 denotes ganglion cell
T16164 1267-1277 GO:0008219 denotes cell death
T16165 1340-1344 PR:000006854 denotes E2f3
T16166 1430-1434 PR:000006854 denotes E2f3
T16167 1491-1493 PR:000013773 denotes Rb
T16123 0-2 PR:000013773 denotes Rb
T16124 53-61 CL:0000540 denotes neuronal
T16125 77-85 UBERON:0004288 denotes skeletal
T16126 94-104 CL:0000136 denotes adipocytes
T16127 116-118 PR:000013773 denotes Rb
T16128 153-159 UBERON:0000479 denotes tissue
T16129 252-254 PR:000013773 denotes Rb
T16130 275-281 UBERON:0000966 denotes retina
T16131 369-371 PR:000013773 denotes Rb
T16132 422-432 GO:0007049 denotes cell cycle
T16133 422-426 _FRAGMENT denotes cell
T16134 436-441 GO:0008219 denotes death
T16135 512-520 GO:0065007 denotes regulate
T16136 542-547 SO:0000704 denotes genes
T16137 581-585 PR:000006853 denotes E2f2
T16138 589-593 PR:000006854 denotes E2f3
T16139 608-610 PR:000013773 denotes Rb
T16140 655-659 PR:000006852 denotes E2f1
T16141 688-695 GO:0007067 denotes mitosis
T16142 750-754 PR:000006853 denotes E2f2
T16143 829-833 PR:000006854 denotes E2f3
T16144 867-874 GO:0007067 denotes mitosis
T16145 887-892 PR:000004968 denotes Calb2
T16146 894-901 PR:000014968 denotes Slc18a3
T16147 909-913 CHEBI:16865 denotes GABA
T16148 915-921 PR:000000940 denotes Kcnc1b
T16149 923-928 PR:000000782 denotes Kcnc2
T16150 934-938 PR:000015851 denotes Sv2c
T16151 998-1000 PR:000013773 denotes Rb
T16152 1001-1005 PR:000006854 denotes E2f3
T16153 1062-1068 UBERON:0000966 denotes retina
T16154 1108-1116 GO:0045202 denotes synaptic
T16155 1152-1156 PR:000006852 denotes E2f1
T16156 1203-1205 PR:000013773 denotes Rb
T16157 1206-1210 PR:000006852 denotes E2f1
T16168 1508-1512 PR:000006854 denotes E2f3
R4449 T16134 T16133 _lexicallyChainedTo death,cell
R4450 T16161 T16160 _lexicallyChainedTo cell,bipolar

2_test

Id Subject Object Predicate Lexical cue
17608565-11447760-84868995 33-35 11447760 denotes 43
17608565-8381715-84868996 221-223 8381715 denotes 31
17608565-11545733-84868996 221-223 11545733 denotes 31
17608565-8946919-84868996 221-223 8946919 denotes 31
17608565-11159908-84868997 549-551 11159908 denotes 44
17608565-12110166-84868997 549-551 12110166 denotes 44
17608565-12975318-84868997 549-551 12975318 denotes 44
17608565-15479636-84868997 549-551 15479636 denotes 44
17608565-16081278-84868997 549-551 16081278 denotes 44
T27346 33-35 11447760 denotes 43
T67368 221-223 8381715 denotes 31
T65967 221-223 11545733 denotes 31
T79277 221-223 8946919 denotes 31
T48689 549-551 11159908 denotes 44
T1759 549-551 12110166 denotes 44
T21385 549-551 12975318 denotes 44
T89101 549-551 15479636 denotes 44
T28753 549-551 16081278 denotes 44