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Id Subject Object Predicate Lexical cue
T16891 2350-2351 -LRB- denotes (
T16892 2358-2360 NN denotes 4C
T16893 2351-2357 NN denotes Figure
T16394 0-2 NN denotes Rb
T16395 3-12 VBZ denotes Regulates
T16396 13-16 NN denotes SAC
T16397 17-32 NN denotes Differentiation
T16398 33-40 IN denotes through
T16399 41-45 NN denotes E2f3
T16400 45-274 sentence denotes Rb binds more than 100 proteins [43] and in some non-neuronal cells, such as skeletal muscle, adipocytes, and bone, Rb is thought to bind and potentiate tissue-specific transcription factors that promote differentiation [31–33].
T16401 46-48 NN denotes Rb
T16402 49-54 VBZ denotes binds
T16403 55-59 JJR denotes more
T16404 65-68 CD denotes 100
T16405 60-64 IN denotes than
T16406 69-77 NN denotes proteins
T16407 78-79 -LRB- denotes [
T16408 79-81 CD denotes 43
T16409 81-82 -RRB- denotes ]
T16410 83-86 CC denotes and
T16411 87-89 IN denotes in
T16412 168-175 VBN denotes thought
T16413 90-94 DT denotes some
T16414 108-113 NNS denotes cells
T16415 95-107 JJ denotes non-neuronal
T16416 113-115 , denotes ,
T16417 115-119 JJ denotes such
T16418 120-122 IN denotes as
T16419 123-131 JJ denotes skeletal
T16420 132-138 NN denotes muscle
T16421 138-140 , denotes ,
T16422 140-150 NNS denotes adipocytes
T16423 150-152 , denotes ,
T16424 152-155 CC denotes and
T16425 156-160 NN denotes bone
T16426 160-162 , denotes ,
T16427 162-164 NN denotes Rb
T16428 165-167 VBZ denotes is
T16429 176-178 TO denotes to
T16430 179-183 VB denotes bind
T16431 184-187 CC denotes and
T16432 188-198 VB denotes potentiate
T16433 199-205 NN denotes tissue
T16434 206-214 JJ denotes specific
T16435 205-206 HYPH denotes -
T16436 229-236 NNS denotes factors
T16437 215-228 NN denotes transcription
T16438 237-241 WDT denotes that
T16439 242-249 VBP denotes promote
T16440 250-265 NN denotes differentiation
T16441 266-267 -LRB- denotes [
T16442 267-269 CD denotes 31
T16443 269-270 SYM denotes –
T16444 270-272 CD denotes 33
T16445 272-273 -RRB- denotes ]
T16446 273-274 . denotes .
T16447 274-379 sentence denotes Thus, we expected that Rb might interact with retina-specific factors to facilitate SAC differentiation.
T16448 275-279 RB denotes Thus
T16449 284-292 VBD denotes expected
T16450 279-281 , denotes ,
T16451 281-283 PRP denotes we
T16452 293-297 IN denotes that
T16453 307-315 VB denotes interact
T16454 298-300 NN denotes Rb
T16455 301-306 MD denotes might
T16456 316-320 IN denotes with
T16457 321-327 NN denotes retina
T16458 328-336 JJ denotes specific
T16459 327-328 HYPH denotes -
T16460 337-344 NNS denotes factors
T16461 345-347 TO denotes to
T16462 348-358 VB denotes facilitate
T16463 359-362 NN denotes SAC
T16464 363-378 NN denotes differentiation
T16465 378-379 . denotes .
T16466 379-675 sentence denotes A direct role for E2f in mediating Rb-dependent differentiation defects (independent of cell cycle or death defects) has to our knowledge not been described, but because E2f can regulate some differentiation genes [44–48], we first tested whether E2f2 or E2f3 might perturb Rb KO SAC maturation.
T16467 380-381 DT denotes A
T16468 389-393 NN denotes role
T16469 382-388 JJ denotes direct
T16470 527-536 VBN denotes described
T16471 394-397 IN denotes for
T16472 398-401 NN denotes E2f
T16473 402-404 IN denotes in
T16474 405-414 VBG denotes mediating
T16475 415-417 NN denotes Rb
T16476 418-427 JJ denotes dependent
T16477 417-418 HYPH denotes -
T16478 444-451 NNS denotes defects
T16479 428-443 NN denotes differentiation
T16480 452-453 -LRB- denotes (
T16481 453-464 JJ denotes independent
T16482 465-467 IN denotes of
T16483 468-472 NN denotes cell
T16484 473-478 NN denotes cycle
T16485 488-495 NNS denotes defects
T16486 479-481 CC denotes or
T16487 482-487 NN denotes death
T16488 495-496 -RRB- denotes )
T16489 497-500 VBZ denotes has
T16490 501-503 IN denotes to
T16491 504-507 PRP$ denotes our
T16492 508-517 NN denotes knowledge
T16493 518-521 RB denotes not
T16494 522-526 VBN denotes been
T16495 536-538 , denotes ,
T16496 538-541 CC denotes but
T16497 542-549 IN denotes because
T16498 558-566 VB denotes regulate
T16499 550-553 NN denotes E2f
T16500 554-557 MD denotes can
T16501 612-618 VBD denotes tested
T16502 567-571 DT denotes some
T16503 588-593 NNS denotes genes
T16504 572-587 NN denotes differentiation
T16505 594-595 -LRB- denotes [
T16506 595-597 CD denotes 44
T16507 597-598 SYM denotes –
T16508 598-600 CD denotes 48
T16509 600-601 -RRB- denotes ]
T16510 601-603 , denotes ,
T16511 603-605 PRP denotes we
T16512 606-611 RB denotes first
T16513 619-626 IN denotes whether
T16514 646-653 VB denotes perturb
T16515 627-631 NN denotes E2f2
T16516 632-634 CC denotes or
T16517 635-639 NN denotes E2f3
T16518 640-645 MD denotes might
T16519 654-656 NN denotes Rb
T16520 657-659 NN denotes KO
T16521 660-663 NN denotes SAC
T16522 664-674 NN denotes maturation
T16523 674-675 . denotes .
T16524 675-853 sentence denotes At multiple time points, E2f1 deletion suppressed ectopic mitosis (PH3+ cells), but did not reverse the SAC defect, and E2f2 deletion had no effect on either defect (Figure 4A).
T16525 676-678 IN denotes At
T16526 715-725 VBD denotes suppressed
T16527 679-687 JJ denotes multiple
T16528 693-699 NNS denotes points
T16529 688-692 NN denotes time
T16530 699-701 , denotes ,
T16531 701-705 NN denotes E2f1
T16532 706-714 NN denotes deletion
T16533 726-733 JJ denotes ectopic
T16534 734-741 NN denotes mitosis
T16535 742-743 -LRB- denotes (
T16536 748-753 NNS denotes cells
T16537 743-746 NN denotes PH3
T16538 746-747 SYM denotes +
T16539 753-754 -RRB- denotes )
T16540 754-756 , denotes ,
T16541 756-759 CC denotes but
T16542 760-763 VBD denotes did
T16543 768-775 VB denotes reverse
T16544 764-767 RB denotes not
T16545 776-779 DT denotes the
T16546 784-790 NN denotes defect
T16547 780-783 NN denotes SAC
T16548 790-792 , denotes ,
T16549 792-795 CC denotes and
T16550 796-800 NN denotes E2f2
T16551 801-809 NN denotes deletion
T16552 810-813 VBD denotes had
T16553 814-816 DT denotes no
T16554 817-823 NN denotes effect
T16555 824-826 IN denotes on
T16556 827-833 CC denotes either
T16557 834-840 NN denotes defect
T16558 841-842 -LRB- denotes (
T16559 849-851 NN denotes 4A
T16560 842-848 NN denotes Figure
T16561 851-852 -RRB- denotes )
T16562 852-853 . denotes .
T16563 853-1043 sentence denotes Remarkably, although E2f3 deletion did not reverse ectopic mitosis, it rescued Calb2, Slc18a3, Chat, GABA, Kcnc1b, Kcnc2, and Sv2c staining at multiple times (Figure 4A and data not shown).
T16564 854-864 RB denotes Remarkably
T16565 925-932 VBD denotes rescued
T16566 864-866 , denotes ,
T16567 866-874 IN denotes although
T16568 897-904 VB denotes reverse
T16569 875-879 NN denotes E2f3
T16570 880-888 NN denotes deletion
T16571 889-892 VBD denotes did
T16572 893-896 RB denotes not
T16573 905-912 JJ denotes ectopic
T16574 913-920 NN denotes mitosis
T16575 920-922 , denotes ,
T16576 922-924 PRP denotes it
T16577 933-938 NN denotes Calb2
T16578 985-993 NN denotes staining
T16579 938-940 , denotes ,
T16580 940-947 NN denotes Slc18a3
T16581 947-949 , denotes ,
T16582 949-953 NN denotes Chat
T16583 953-955 , denotes ,
T16584 955-959 NN denotes GABA
T16585 959-961 , denotes ,
T16586 961-967 NN denotes Kcnc1b
T16587 967-969 , denotes ,
T16588 969-974 NN denotes Kcnc2
T16589 974-976 , denotes ,
T16590 976-979 CC denotes and
T16591 980-984 NN denotes Sv2c
T16592 994-996 IN denotes at
T16593 997-1005 JJ denotes multiple
T16594 1006-1011 NNS denotes times
T16595 1012-1013 -LRB- denotes (
T16596 1020-1022 NN denotes 4A
T16597 1013-1019 NN denotes Figure
T16598 1023-1026 CC denotes and
T16599 1027-1031 NNS denotes data
T16600 1036-1041 VBN denotes shown
T16601 1032-1035 RB denotes not
T16602 1041-1042 -RRB- denotes )
T16603 1042-1043 . denotes .
T16604 1043-1203 sentence denotes Rb/E2f3 DKO SAC tracks were slightly more disordered than in WT retina, most likely because of the absence of synaptic partner cells, which are killed by E2f1.
T16605 1044-1046 NN denotes Rb
T16606 1047-1051 NN denotes E2f3
T16607 1046-1047 HYPH denotes /
T16608 1052-1055 NN denotes DKO
T16609 1056-1059 NN denotes SAC
T16610 1060-1066 NNS denotes tracks
T16611 1067-1071 VBD denotes were
T16612 1072-1080 RB denotes slightly
T16613 1081-1085 RBR denotes more
T16614 1086-1096 VBN denotes disordered
T16615 1097-1101 IN denotes than
T16616 1102-1104 IN denotes in
T16617 1105-1107 NN denotes WT
T16618 1108-1114 NN denotes retina
T16619 1114-1116 , denotes ,
T16620 1116-1120 RBS denotes most
T16621 1121-1127 RB denotes likely
T16622 1128-1135 IN denotes because
T16623 1136-1138 IN denotes of
T16624 1139-1142 DT denotes the
T16625 1143-1150 NN denotes absence
T16626 1151-1153 IN denotes of
T16627 1154-1162 JJ denotes synaptic
T16628 1171-1176 NNS denotes cells
T16629 1163-1170 NN denotes partner
T16630 1176-1178 , denotes ,
T16631 1178-1183 WDT denotes which
T16632 1188-1194 VBN denotes killed
T16633 1184-1187 VBP denotes are
T16634 1195-1197 IN denotes by
T16635 1198-1202 NN denotes E2f1
T16636 1202-1203 . denotes .
T16637 1203-1385 sentence denotes Indeed, this minor defect was rescued in the Rb/E2f1/E2f3 triple knockout retina, where bipolar and ganglion cell death was rescued and SAC differentiation was restored (Figure 4A).
T16638 1204-1210 RB denotes Indeed
T16639 1234-1241 VBN denotes rescued
T16640 1210-1212 , denotes ,
T16641 1212-1216 DT denotes this
T16642 1223-1229 NN denotes defect
T16643 1217-1222 JJ denotes minor
T16644 1230-1233 VBD denotes was
T16645 1242-1244 IN denotes in
T16646 1245-1248 DT denotes the
T16647 1278-1284 NN denotes retina
T16648 1249-1251 NN denotes Rb
T16649 1257-1261 NN denotes E2f3
T16650 1251-1252 HYPH denotes /
T16651 1252-1256 NN denotes E2f1
T16652 1256-1257 HYPH denotes /
T16653 1269-1277 NN denotes knockout
T16654 1262-1268 JJ denotes triple
T16655 1284-1286 , denotes ,
T16656 1286-1291 WRB denotes where
T16657 1328-1335 VBN denotes rescued
T16658 1292-1299 JJ denotes bipolar
T16659 1313-1317 NN denotes cell
T16660 1300-1303 CC denotes and
T16661 1304-1312 NN denotes ganglion
T16662 1318-1323 NN denotes death
T16663 1324-1327 VBD denotes was
T16664 1336-1339 CC denotes and
T16665 1340-1343 NN denotes SAC
T16666 1344-1359 NN denotes differentiation
T16667 1364-1372 VBN denotes restored
T16668 1360-1363 VBD denotes was
T16669 1373-1374 -LRB- denotes (
T16670 1381-1383 NN denotes 4A
T16671 1374-1380 NN denotes Figure
T16672 1383-1384 -RRB- denotes )
T16673 1384-1385 . denotes .
T16674 1385-1559 sentence denotes E2f3 deletion alone did not affect SAC differentiation (Figure 4A); thus, it is unleashed E2f3 activity that is detrimental, and the critical role for Rb is to inhibit E2f3.
T16675 1386-1390 NN denotes E2f3
T16676 1391-1399 NN denotes deletion
T16677 1414-1420 VB denotes affect
T16678 1400-1405 RB denotes alone
T16679 1406-1409 VBD denotes did
T16680 1410-1413 RB denotes not
T16681 1421-1424 NN denotes SAC
T16682 1425-1440 NN denotes differentiation
T16683 1441-1442 -LRB- denotes (
T16684 1449-1451 NN denotes 4A
T16685 1442-1448 NN denotes Figure
T16686 1451-1452 -RRB- denotes )
T16687 1452-1453 : denotes ;
T16688 1454-1458 RB denotes thus
T16689 1463-1465 VBZ denotes is
T16690 1458-1460 , denotes ,
T16691 1460-1462 PRP denotes it
T16692 1466-1475 VBN denotes unleashed
T16693 1481-1489 NN denotes activity
T16694 1476-1480 NN denotes E2f3
T16695 1490-1494 WDT denotes that
T16696 1495-1497 VBZ denotes is
T16697 1498-1509 JJ denotes detrimental
T16698 1509-1511 , denotes ,
T16699 1511-1514 CC denotes and
T16700 1515-1518 DT denotes the
T16701 1528-1532 NN denotes role
T16702 1519-1527 JJ denotes critical
T16703 1540-1542 VBZ denotes is
T16704 1533-1536 IN denotes for
T16705 1537-1539 NN denotes Rb
T16706 1543-1545 TO denotes to
T16707 1546-1553 VB denotes inhibit
T16708 1554-1558 NN denotes E2f3
T16709 1558-1559 . denotes .
T16710 1559-1851 sentence denotes We quantified the fraction of Camk2a+ SACs in different genotypes and found that 60% of WT P30 Camk2a+ cells expressed Chat and Slc18a3, which dropped to only 5.6% in the Rb KO retina, and remained low at 3.7% in the Rb/E2f1 DKO retina, but rose to 91% in the Rb/E2f3 DKO retina (Figure 4B).
T16711 1560-1562 PRP denotes We
T16712 1563-1573 VBD denotes quantified
T16713 1574-1577 DT denotes the
T16714 1578-1586 NN denotes fraction
T16715 1587-1589 IN denotes of
T16716 1590-1596 NN denotes Camk2a
T16717 1598-1602 NNS denotes SACs
T16718 1596-1597 SYM denotes +
T16719 1603-1605 IN denotes in
T16720 1606-1615 JJ denotes different
T16721 1616-1625 NNS denotes genotypes
T16722 1626-1629 CC denotes and
T16723 1630-1635 VBD denotes found
T16724 1636-1640 IN denotes that
T16725 1669-1678 VBD denotes expressed
T16726 1641-1643 CD denotes 60
T16727 1643-1644 NN denotes %
T16728 1645-1647 IN denotes of
T16729 1648-1650 NN denotes WT
T16730 1663-1668 NNS denotes cells
T16731 1651-1654 NN denotes P30
T16732 1655-1661 NN denotes Camk2a
T16733 1661-1662 SYM denotes +
T16734 1679-1683 NN denotes Chat
T16735 1684-1687 CC denotes and
T16736 1688-1695 NN denotes Slc18a3
T16737 1695-1697 , denotes ,
T16738 1697-1702 WDT denotes which
T16739 1703-1710 VBD denotes dropped
T16740 1711-1713 IN denotes to
T16741 1714-1718 RB denotes only
T16742 1719-1722 CD denotes 5.6
T16743 1722-1723 NN denotes %
T16744 1724-1726 IN denotes in
T16745 1727-1730 DT denotes the
T16746 1737-1743 NN denotes retina
T16747 1731-1733 NN denotes Rb
T16748 1734-1736 NN denotes KO
T16749 1743-1745 , denotes ,
T16750 1745-1748 CC denotes and
T16751 1749-1757 VBD denotes remained
T16752 1758-1761 JJ denotes low
T16753 1762-1764 IN denotes at
T16754 1765-1768 CD denotes 3.7
T16755 1768-1769 NN denotes %
T16756 1770-1772 IN denotes in
T16757 1773-1776 DT denotes the
T16758 1789-1795 NN denotes retina
T16759 1777-1779 NN denotes Rb
T16760 1780-1784 NN denotes E2f1
T16761 1779-1780 HYPH denotes /
T16762 1785-1788 NN denotes DKO
T16763 1795-1797 , denotes ,
T16764 1797-1800 CC denotes but
T16765 1801-1805 VBD denotes rose
T16766 1806-1808 IN denotes to
T16767 1809-1811 CD denotes 91
T16768 1811-1812 NN denotes %
T16769 1813-1815 IN denotes in
T16770 1816-1819 DT denotes the
T16771 1832-1838 NN denotes retina
T16772 1820-1822 NN denotes Rb
T16773 1823-1827 NN denotes E2f3
T16774 1822-1823 HYPH denotes /
T16775 1828-1831 NN denotes DKO
T16776 1839-1840 -LRB- denotes (
T16777 1847-1849 NN denotes 4B
T16778 1840-1846 NN denotes Figure
T16779 1849-1850 -RRB- denotes )
T16780 1850-1851 . denotes .
T16781 1851-1984 sentence denotes The latter fraction is higher than WT because ganglion cells, which normally make up ~40% of Camk2a+ cells, are killed by apoptosis.
T16782 1852-1855 DT denotes The
T16783 1863-1871 NN denotes fraction
T16784 1856-1862 JJ denotes latter
T16785 1872-1874 VBZ denotes is
T16786 1875-1881 JJR denotes higher
T16787 1882-1886 IN denotes than
T16788 1887-1889 NN denotes WT
T16789 1890-1897 IN denotes because
T16790 1964-1970 VBN denotes killed
T16791 1898-1906 NN denotes ganglion
T16792 1907-1912 NNS denotes cells
T16793 1912-1914 , denotes ,
T16794 1914-1919 WDT denotes which
T16795 1929-1933 VBP denotes make
T16796 1920-1928 RB denotes normally
T16797 1934-1936 RP denotes up
T16798 1937-1938 SYM denotes ~
T16799 1938-1940 CD denotes 40
T16800 1940-1941 NN denotes %
T16801 1942-1944 IN denotes of
T16802 1945-1951 NN denotes Camk2a
T16803 1953-1958 NNS denotes cells
T16804 1951-1952 SYM denotes +
T16805 1958-1960 , denotes ,
T16806 1960-1963 VBP denotes are
T16807 1971-1973 IN denotes by
T16808 1974-1983 NN denotes apoptosis
T16809 1983-1984 . denotes .
T16810 1984-2095 sentence denotes To quantify the effect of different E2fs on ectopic division specifically in SACs, we exploited Isl1 (Islet1).
T16811 1985-1987 TO denotes To
T16812 1988-1996 VB denotes quantify
T16813 2071-2080 VBD denotes exploited
T16814 1997-2000 DT denotes the
T16815 2001-2007 NN denotes effect
T16816 2008-2010 IN denotes of
T16817 2011-2020 JJ denotes different
T16818 2021-2025 NNS denotes E2fs
T16819 2026-2028 IN denotes on
T16820 2029-2036 JJ denotes ectopic
T16821 2037-2045 NN denotes division
T16822 2046-2058 RB denotes specifically
T16823 2059-2061 IN denotes in
T16824 2062-2066 NNS denotes SACs
T16825 2066-2068 , denotes ,
T16826 2068-2070 PRP denotes we
T16827 2081-2085 NN denotes Isl1
T16828 2086-2087 -LRB- denotes (
T16829 2087-2093 NN denotes Islet1
T16830 2093-2094 -RRB- denotes )
T16831 2094-2095 . denotes .
T16832 2095-2208 sentence denotes This marker is expressed in both SACs and ganglion cells, thus Isl1+ cells in the INL are exclusively SACs [49].
T16833 2096-2100 DT denotes This
T16834 2101-2107 NN denotes marker
T16835 2111-2120 VBN denotes expressed
T16836 2108-2110 VBZ denotes is
T16837 2182-2185 VBP denotes are
T16838 2121-2123 IN denotes in
T16839 2124-2128 CC denotes both
T16840 2129-2133 NNS denotes SACs
T16841 2134-2137 CC denotes and
T16842 2138-2146 NN denotes ganglion
T16843 2147-2152 NNS denotes cells
T16844 2152-2154 , denotes ,
T16845 2154-2158 RB denotes thus
T16846 2159-2163 NN denotes Isl1
T16847 2165-2170 NNS denotes cells
T16848 2163-2164 SYM denotes +
T16849 2171-2173 IN denotes in
T16850 2174-2177 DT denotes the
T16851 2178-2181 NN denotes INL
T16852 2186-2197 RB denotes exclusively
T16853 2198-2202 NNS denotes SACs
T16854 2203-2204 -LRB- denotes [
T16855 2204-2206 CD denotes 49
T16856 2206-2207 -RRB- denotes ]
T16857 2207-2208 . denotes .
T16858 2208-2362 sentence denotes We found that 98.2% ± 1.8% of Isl1+ cells in the forming inner INL at P5 were also Slc18a3+, confirming that Isl1 is an excellent SAC marker (Figure 4C).
T16859 2209-2211 PRP denotes We
T16860 2212-2217 VBD denotes found
T16861 2218-2222 IN denotes that
T16862 2282-2286 VBD denotes were
T16863 2223-2227 CD denotes 98.2
T16864 2227-2228 NN denotes %
T16865 2229-2230 SYM denotes ±
T16866 2231-2234 CD denotes 1.8
T16867 2234-2235 NN denotes %
T16868 2236-2238 IN denotes of
T16869 2239-2243 NN denotes Isl1
T16870 2245-2250 NNS denotes cells
T16871 2243-2244 SYM denotes +
T16872 2251-2253 IN denotes in
T16873 2254-2257 DT denotes the
T16874 2272-2275 NN denotes INL
T16875 2258-2265 VBG denotes forming
T16876 2266-2271 JJ denotes inner
T16877 2276-2278 IN denotes at
T16878 2279-2281 NN denotes P5
T16879 2287-2291 RB denotes also
T16880 2292-2299 NN denotes Slc18a3
T16881 2299-2300 SYM denotes +
T16882 2300-2302 , denotes ,
T16883 2302-2312 VBG denotes confirming
T16884 2313-2317 IN denotes that
T16885 2323-2325 VBZ denotes is
T16886 2318-2322 NN denotes Isl1
T16887 2326-2328 DT denotes an
T16888 2343-2349 NN denotes marker
T16889 2329-2338 JJ denotes excellent
T16890 2339-2342 NN denotes SAC
T16894 2360-2361 -RRB- denotes )
T16895 2361-2362 . denotes .
T16896 2362-2455 sentence denotes Moreover, Isl1, unlike Slc18a3, is nuclear, which facilitates scoring of Isl1+/Mki67+ cells.
T16897 2363-2371 RB denotes Moreover
T16898 2395-2397 VBZ denotes is
T16899 2371-2373 , denotes ,
T16900 2373-2377 NN denotes Isl1
T16901 2377-2379 , denotes ,
T16902 2379-2385 IN denotes unlike
T16903 2386-2393 NN denotes Slc18a3
T16904 2393-2395 , denotes ,
T16905 2398-2405 JJ denotes nuclear
T16906 2405-2407 , denotes ,
T16907 2407-2412 WDT denotes which
T16908 2413-2424 VBZ denotes facilitates
T16909 2425-2432 NN denotes scoring
T16910 2433-2435 IN denotes of
T16911 2436-2440 NN denotes Isl1
T16912 2449-2454 NNS denotes cells
T16913 2440-2441 SYM denotes +
T16914 2441-2442 HYPH denotes /
T16915 2442-2447 NN denotes Mki67
T16916 2447-2448 SYM denotes +
T16917 2454-2455 . denotes .
T16918 2455-2740 sentence denotes It is also expressed earlier than Slc18a3, permitting analysis of SACs soon after their birth at ~E15; thus, we could study retina at P0, a time when ectopic division is high in the inner retina and prior to Rb-independent cell cycle exit associated with terminal differentiation [2].
T16919 2456-2458 PRP denotes It
T16920 2467-2476 VBN denotes expressed
T16921 2459-2461 VBZ denotes is
T16922 2462-2466 RB denotes also
T16923 2574-2579 VB denotes study
T16924 2477-2484 RBR denotes earlier
T16925 2485-2489 IN denotes than
T16926 2490-2497 NN denotes Slc18a3
T16927 2497-2499 , denotes ,
T16928 2499-2509 VBG denotes permitting
T16929 2510-2518 NN denotes analysis
T16930 2519-2521 IN denotes of
T16931 2522-2526 NNS denotes SACs
T16932 2527-2531 RB denotes soon
T16933 2532-2537 IN denotes after
T16934 2538-2543 PRP$ denotes their
T16935 2544-2549 NN denotes birth
T16936 2550-2552 IN denotes at
T16937 2553-2554 SYM denotes ~
T16938 2554-2557 NN denotes E15
T16939 2557-2558 : denotes ;
T16940 2559-2563 RB denotes thus
T16941 2563-2565 , denotes ,
T16942 2565-2567 PRP denotes we
T16943 2568-2573 MD denotes could
T16944 2580-2586 NN denotes retina
T16945 2587-2589 IN denotes at
T16946 2590-2592 NN denotes P0
T16947 2592-2594 , denotes ,
T16948 2594-2595 DT denotes a
T16949 2596-2600 NN denotes time
T16950 2601-2605 WRB denotes when
T16951 2623-2625 VBZ denotes is
T16952 2606-2613 JJ denotes ectopic
T16953 2614-2622 NN denotes division
T16954 2626-2630 JJ denotes high
T16955 2631-2633 IN denotes in
T16956 2634-2637 DT denotes the
T16957 2644-2650 NN denotes retina
T16958 2638-2643 JJ denotes inner
T16959 2651-2654 CC denotes and
T16960 2655-2660 RB denotes prior
T16961 2661-2663 IN denotes to
T16962 2664-2666 NN denotes Rb
T16963 2667-2678 JJ denotes independent
T16964 2666-2667 HYPH denotes -
T16965 2690-2694 NN denotes exit
T16966 2679-2683 NN denotes cell
T16967 2684-2689 NN denotes cycle
T16968 2695-2705 VBN denotes associated
T16969 2706-2710 IN denotes with
T16970 2711-2719 JJ denotes terminal
T16971 2720-2735 NN denotes differentiation
T16972 2736-2737 -LRB- denotes [
T16973 2737-2738 CD denotes 2
T16974 2738-2739 -RRB- denotes ]
T16975 2739-2740 . denotes .
T16976 2740-2925 sentence denotes At P0, no WT Isl1+ cells in the inner neuroblastic layer (NBL) (which is the future INL) were dividing, but 57 ± 14 Isl1+/Mki67+ cells were detected in the Rb KO inner NBL (Figure 4D).
T16977 2741-2743 IN denotes At
T16978 2835-2843 VBG denotes dividing
T16979 2744-2746 NN denotes P0
T16980 2746-2748 , denotes ,
T16981 2748-2750 DT denotes no
T16982 2760-2765 NNS denotes cells
T16983 2751-2753 NN denotes WT
T16984 2754-2758 NN denotes Isl1
T16985 2758-2759 SYM denotes +
T16986 2766-2768 IN denotes in
T16987 2769-2772 DT denotes the
T16988 2792-2797 NN denotes layer
T16989 2773-2778 JJ denotes inner
T16990 2779-2791 JJ denotes neuroblastic
T16991 2798-2799 -LRB- denotes (
T16992 2799-2802 NN denotes NBL
T16993 2802-2803 -RRB- denotes )
T16994 2804-2805 -LRB- denotes (
T16995 2805-2810 WDT denotes which
T16996 2811-2813 VBZ denotes is
T16997 2814-2817 DT denotes the
T16998 2825-2828 NN denotes INL
T16999 2818-2824 JJ denotes future
T17000 2828-2829 -RRB- denotes )
T17001 2830-2834 VBD denotes were
T17002 2843-2845 , denotes ,
T17003 2845-2848 CC denotes but
T17004 2849-2851 CD denotes 57
T17005 2854-2856 CD denotes 14
T17006 2852-2853 SYM denotes ±
T17007 2870-2875 NNS denotes cells
T17008 2857-2861 NN denotes Isl1
T17009 2861-2862 SYM denotes +
T17010 2862-2863 HYPH denotes /
T17011 2863-2868 NN denotes Mki67
T17012 2868-2869 SYM denotes +
T17013 2881-2889 VBN denotes detected
T17014 2876-2880 VBD denotes were
T17015 2890-2892 IN denotes in
T17016 2893-2896 DT denotes the
T17017 2909-2912 NN denotes NBL
T17018 2897-2899 NN denotes Rb
T17019 2900-2902 NN denotes KO
T17020 2903-2908 JJ denotes inner
T17021 2913-2914 -LRB- denotes (
T17022 2921-2923 NN denotes 4D
T17023 2914-2920 NN denotes Figure
T17024 2923-2924 -RRB- denotes )
T17025 2924-2925 . denotes .
T17026 2925-3107 sentence denotes Indeed, about one-third of all Isl1+ cells in the entire inner NBL were dividing in the Rb KO retina, or ~50% in the periphery where Cre is expressed (Figure 4E and data not shown).
T17027 2926-2932 RB denotes Indeed
T17028 2998-3006 VBG denotes dividing
T17029 2932-2934 , denotes ,
T17030 2934-2939 IN denotes about
T17031 2940-2943 CD denotes one
T17032 2943-2944 HYPH denotes -
T17033 2944-2949 NN denotes third
T17034 2950-2952 IN denotes of
T17035 2953-2956 DT denotes all
T17036 2963-2968 NNS denotes cells
T17037 2957-2961 NN denotes Isl1
T17038 2961-2962 SYM denotes +
T17039 2969-2971 IN denotes in
T17040 2972-2975 DT denotes the
T17041 2989-2992 NN denotes NBL
T17042 2976-2982 JJ denotes entire
T17043 2983-2988 JJ denotes inner
T17044 2993-2997 VBD denotes were
T17045 3007-3009 IN denotes in
T17046 3010-3013 DT denotes the
T17047 3020-3026 NN denotes retina
T17048 3014-3016 NN denotes Rb
T17049 3017-3019 NN denotes KO
T17050 3026-3028 , denotes ,
T17051 3028-3030 CC denotes or
T17052 3031-3032 SYM denotes ~
T17053 3032-3034 CD denotes 50
T17054 3034-3035 NN denotes %
T17055 3036-3038 IN denotes in
T17056 3039-3042 DT denotes the
T17057 3043-3052 NN denotes periphery
T17058 3053-3058 WRB denotes where
T17059 3066-3075 VBN denotes expressed
T17060 3059-3062 NN denotes Cre
T17061 3063-3065 VBZ denotes is
T17062 3076-3077 -LRB- denotes (
T17063 3084-3086 NN denotes 4E
T17064 3077-3083 NN denotes Figure
T17065 3087-3090 CC denotes and
T17066 3091-3095 NNS denotes data
T17067 3100-3105 VBN denotes shown
T17068 3096-3099 RB denotes not
T17069 3105-3106 -RRB- denotes )
T17070 3106-3107 . denotes .
T17071 3107-3294 sentence denotes This defect was suppressed in the Rb/E2f1 DKO retina, where we detected only 1 ± 1 dividing SAC, but not the Rb/E2f3 DKO retina, where there were 53 ± 8 dividing SACs (Figure 4D and 4E).
T17072 3108-3112 DT denotes This
T17073 3113-3119 NN denotes defect
T17074 3124-3134 VBN denotes suppressed
T17075 3120-3123 VBD denotes was
T17076 3135-3137 IN denotes in
T17077 3138-3141 DT denotes the
T17078 3154-3160 NN denotes retina
T17079 3142-3144 NN denotes Rb
T17080 3145-3149 NN denotes E2f1
T17081 3144-3145 HYPH denotes /
T17082 3150-3153 NN denotes DKO
T17083 3160-3162 , denotes ,
T17084 3162-3167 WRB denotes where
T17085 3171-3179 VBD denotes detected
T17086 3168-3170 PRP denotes we
T17087 3180-3184 RB denotes only
T17088 3189-3190 CD denotes 1
T17089 3185-3186 CD denotes 1
T17090 3187-3188 SYM denotes ±
T17091 3200-3203 NN denotes SAC
T17092 3191-3199 NN denotes dividing
T17093 3203-3205 , denotes ,
T17094 3205-3208 CC denotes but
T17095 3209-3212 RB denotes not
T17096 3213-3216 DT denotes the
T17097 3229-3235 NN denotes retina
T17098 3217-3219 NN denotes Rb
T17099 3220-3224 NN denotes E2f3
T17100 3219-3220 HYPH denotes /
T17101 3225-3228 NN denotes DKO
T17102 3235-3237 , denotes ,
T17103 3237-3242 WRB denotes where
T17104 3249-3253 VBD denotes were
T17105 3243-3248 EX denotes there
T17106 3254-3256 CD denotes 53
T17107 3259-3260 CD denotes 8
T17108 3257-3258 SYM denotes ±
T17109 3270-3274 NNS denotes SACs
T17110 3261-3269 VBG denotes dividing
T17111 3275-3276 -LRB- denotes (
T17112 3283-3285 NN denotes 4D
T17113 3276-3282 NN denotes Figure
T17114 3286-3289 CC denotes and
T17115 3290-3292 NN denotes 4E
T17116 3292-3293 -RRB- denotes )
T17117 3293-3294 . denotes .
T17118 3294-3408 sentence denotes We observed similar effects at P0 with Calb2, which marks newborn SACs and other amacrine cells (data not shown).
T17119 3295-3297 PRP denotes We
T17120 3298-3306 VBD denotes observed
T17121 3307-3314 JJ denotes similar
T17122 3315-3322 NNS denotes effects
T17123 3323-3325 IN denotes at
T17124 3326-3328 NN denotes P0
T17125 3329-3333 IN denotes with
T17126 3334-3339 NN denotes Calb2
T17127 3339-3341 , denotes ,
T17128 3341-3346 WDT denotes which
T17129 3347-3352 VBZ denotes marks
T17130 3353-3360 JJ denotes newborn
T17131 3361-3365 NNS denotes SACs
T17132 3366-3369 CC denotes and
T17133 3370-3375 JJ denotes other
T17134 3385-3390 NNS denotes cells
T17135 3376-3384 JJ denotes amacrine
T17136 3391-3392 -LRB- denotes (
T17137 3401-3406 VBN denotes shown
T17138 3392-3396 NNS denotes data
T17139 3397-3400 RB denotes not
T17140 3406-3407 -RRB- denotes )
T17141 3407-3408 . denotes .
T17142 3408-3589 sentence denotes Thus, in Rb KO SACs, E2f1 deletion suppresses ectopic division but not aberrant differentiation, whereas E2f3 deletion suppresses aberrant differentiation but not ectopic division.
T17143 3409-3413 RB denotes Thus
T17144 3444-3454 VBZ denotes suppresses
T17145 3413-3415 , denotes ,
T17146 3415-3417 IN denotes in
T17147 3418-3420 NN denotes Rb
T17148 3421-3423 NN denotes KO
T17149 3424-3428 NNS denotes SACs
T17150 3428-3430 , denotes ,
T17151 3430-3434 NN denotes E2f1
T17152 3435-3443 NN denotes deletion
T17153 3455-3462 JJ denotes ectopic
T17154 3463-3471 NN denotes division
T17155 3472-3475 CC denotes but
T17156 3476-3479 RB denotes not
T17157 3480-3488 JJ denotes aberrant
T17158 3489-3504 NN denotes differentiation
T17159 3504-3506 , denotes ,
T17160 3506-3513 IN denotes whereas
T17161 3528-3538 VBZ denotes suppresses
T17162 3514-3518 NN denotes E2f3
T17163 3519-3527 NN denotes deletion
T17164 3539-3547 JJ denotes aberrant
T17165 3548-3563 NN denotes differentiation
T17166 3564-3567 CC denotes but
T17167 3568-3571 RB denotes not
T17168 3572-3579 JJ denotes ectopic
T17169 3580-3588 NN denotes division
T17170 3588-3589 . denotes .
R4453 T16394 T16395 nsubj Rb,Regulates
R4454 T16396 T16397 compound SAC,Differentiation
R4455 T16397 T16395 dobj Differentiation,Regulates
R4456 T16398 T16395 prep through,Regulates
R4457 T16399 T16398 pobj E2f3,through
R4458 T16401 T16402 nsubj Rb,binds
R4459 T16403 T16404 amod more,100
R4460 T16404 T16406 nummod 100,proteins
R4461 T16405 T16404 quantmod than,100
R4462 T16406 T16402 dobj proteins,binds
R4463 T16407 T16408 punct [,43
R4464 T16408 T16402 parataxis 43,binds
R4465 T16409 T16408 punct ],43
R4466 T16410 T16402 cc and,binds
R4467 T16411 T16412 prep in,thought
R4468 T16412 T16402 conj thought,binds
R4469 T16413 T16414 det some,cells
R4470 T16414 T16411 pobj cells,in
R4471 T16415 T16414 amod non-neuronal,cells
R4472 T16416 T16414 punct ", ",cells
R4473 T16417 T16418 amod such,as
R4474 T16418 T16414 prep as,cells
R4475 T16419 T16420 amod skeletal,muscle
R4476 T16420 T16418 pobj muscle,as
R4477 T16421 T16420 punct ", ",muscle
R4478 T16422 T16420 conj adipocytes,muscle
R4479 T16423 T16422 punct ", ",adipocytes
R4480 T16424 T16422 cc and,adipocytes
R4481 T16425 T16422 conj bone,adipocytes
R4482 T16426 T16412 punct ", ",thought
R4483 T16427 T16412 nsubjpass Rb,thought
R4484 T16428 T16412 auxpass is,thought
R4485 T16429 T16430 aux to,bind
R4486 T16430 T16412 xcomp bind,thought
R4487 T16431 T16430 cc and,bind
R4488 T16432 T16430 conj potentiate,bind
R4489 T16433 T16434 npadvmod tissue,specific
R4490 T16434 T16436 amod specific,factors
R4491 T16435 T16434 punct -,specific
R4492 T16436 T16432 dobj factors,potentiate
R4493 T16437 T16436 compound transcription,factors
R4494 T16438 T16439 dep that,promote
R4495 T16439 T16436 relcl promote,factors
R4496 T16440 T16439 dobj differentiation,promote
R4497 T16441 T16442 punct [,31
R4498 T16442 T16432 parataxis 31,potentiate
R4499 T16443 T16444 punct –,33
R4500 T16444 T16442 prep 33,31
R4501 T16445 T16442 punct ],31
R4502 T16446 T16412 punct .,thought
R4503 T16448 T16449 advmod Thus,expected
R4504 T16450 T16449 punct ", ",expected
R4505 T16451 T16449 nsubj we,expected
R4506 T16452 T16453 mark that,interact
R4507 T16453 T16449 ccomp interact,expected
R4508 T16454 T16453 nsubj Rb,interact
R4509 T16455 T16453 aux might,interact
R4510 T16456 T16453 prep with,interact
R4511 T16457 T16458 npadvmod retina,specific
R4512 T16458 T16460 amod specific,factors
R4513 T16459 T16458 punct -,specific
R4514 T16460 T16456 pobj factors,with
R4515 T16461 T16462 aux to,facilitate
R4516 T16462 T16453 advcl facilitate,interact
R4517 T16463 T16464 compound SAC,differentiation
R4518 T16464 T16462 dobj differentiation,facilitate
R4519 T16465 T16449 punct .,expected
R4520 T16467 T16468 det A,role
R4521 T16468 T16470 nsubjpass role,described
R4522 T16469 T16468 amod direct,role
R4523 T16471 T16468 prep for,role
R4524 T16472 T16471 pobj E2f,for
R4525 T16473 T16468 prep in,role
R4526 T16474 T16473 pcomp mediating,in
R4527 T16475 T16476 npadvmod Rb,dependent
R4528 T16476 T16478 amod dependent,defects
R4529 T16477 T16476 punct -,dependent
R4530 T16478 T16474 dobj defects,mediating
R4531 T16479 T16478 compound differentiation,defects
R4532 T16480 T16478 punct (,defects
R4533 T16481 T16478 amod independent,defects
R4534 T16482 T16481 prep of,independent
R4535 T16483 T16484 nmod cell,cycle
R4536 T16484 T16485 nmod cycle,defects
R4537 T16485 T16482 pobj defects,of
R4538 T16486 T16484 cc or,cycle
R4539 T16487 T16484 conj death,cycle
R4540 T16488 T16470 punct ),described
R4541 T16489 T16470 aux has,described
R4542 T16490 T16470 prep to,described
R4543 T16491 T16492 poss our,knowledge
R4544 T16492 T16490 pobj knowledge,to
R4545 T16493 T16470 neg not,described
R4546 T16494 T16470 auxpass been,described
R4547 T16495 T16470 punct ", ",described
R4548 T16496 T16470 cc but,described
R4549 T16497 T16498 mark because,regulate
R4550 T16498 T16501 advcl regulate,tested
R4551 T16499 T16498 nsubj E2f,regulate
R4552 T16500 T16498 aux can,regulate
R4553 T16501 T16470 conj tested,described
R4554 T16502 T16503 det some,genes
R4555 T16503 T16498 dobj genes,regulate
R4556 T16504 T16503 compound differentiation,genes
R4557 T16505 T16506 punct [,44
R4558 T16506 T16498 parataxis 44,regulate
R4559 T16507 T16508 punct –,48
R4560 T16508 T16506 prep 48,44
R4561 T16509 T16506 punct ],44
R4562 T16510 T16501 punct ", ",tested
R4563 T16511 T16501 nsubj we,tested
R4564 T16512 T16501 advmod first,tested
R4565 T16513 T16514 mark whether,perturb
R4566 T16514 T16501 ccomp perturb,tested
R4567 T16515 T16514 nsubj E2f2,perturb
R4568 T16516 T16515 cc or,E2f2
R4569 T16517 T16515 conj E2f3,E2f2
R4570 T16518 T16514 aux might,perturb
R4571 T16519 T16520 compound Rb,KO
R4572 T16520 T16521 compound KO,SAC
R4573 T16521 T16522 compound SAC,maturation
R4574 T16522 T16514 dobj maturation,perturb
R4575 T16523 T16501 punct .,tested
R4576 T16525 T16526 prep At,suppressed
R4577 T16527 T16528 amod multiple,points
R4578 T16528 T16525 pobj points,At
R4579 T16529 T16528 compound time,points
R4580 T16530 T16526 punct ", ",suppressed
R4581 T16531 T16532 compound E2f1,deletion
R4582 T16532 T16526 nsubj deletion,suppressed
R4583 T16533 T16534 amod ectopic,mitosis
R4584 T16534 T16526 dobj mitosis,suppressed
R4585 T16535 T16536 punct (,cells
R4586 T16536 T16526 parataxis cells,suppressed
R4587 T16537 T16536 nmod PH3,cells
R4588 T16538 T16537 punct +,PH3
R4589 T16539 T16536 punct ),cells
R4590 T16540 T16526 punct ", ",suppressed
R4591 T16541 T16526 cc but,suppressed
R4592 T16542 T16543 aux did,reverse
R4593 T16543 T16526 conj reverse,suppressed
R4594 T16544 T16543 neg not,reverse
R4595 T16545 T16546 det the,defect
R4596 T16546 T16543 dobj defect,reverse
R4597 T16547 T16546 compound SAC,defect
R4598 T16548 T16526 punct ", ",suppressed
R4599 T16549 T16526 cc and,suppressed
R4600 T16550 T16551 compound E2f2,deletion
R4601 T16551 T16552 nsubj deletion,had
R4602 T16552 T16526 conj had,suppressed
R4603 T16553 T16554 det no,effect
R4604 T16554 T16552 dobj effect,had
R4605 T16555 T16554 prep on,effect
R4606 T16556 T16557 preconj either,defect
R4607 T16557 T16555 pobj defect,on
R4608 T16558 T16559 punct (,4A
R4609 T16559 T16552 parataxis 4A,had
R4610 T16560 T16559 compound Figure,4A
R4611 T16561 T16559 punct ),4A
R4612 T16562 T16552 punct .,had
R4613 T16564 T16565 advmod Remarkably,rescued
R4614 T16566 T16565 punct ", ",rescued
R4615 T16567 T16568 mark although,reverse
R4616 T16568 T16565 advcl reverse,rescued
R4617 T16569 T16570 compound E2f3,deletion
R4618 T16570 T16568 nsubj deletion,reverse
R4619 T16571 T16568 aux did,reverse
R4620 T16572 T16568 neg not,reverse
R4621 T16573 T16574 amod ectopic,mitosis
R4622 T16574 T16568 dobj mitosis,reverse
R4623 T16575 T16565 punct ", ",rescued
R4624 T16576 T16565 nsubj it,rescued
R4625 T16577 T16578 nmod Calb2,staining
R4626 T16578 T16565 dobj staining,rescued
R4627 T16579 T16577 punct ", ",Calb2
R4628 T16580 T16577 conj Slc18a3,Calb2
R4629 T16581 T16580 punct ", ",Slc18a3
R4630 T16582 T16580 conj Chat,Slc18a3
R4631 T16583 T16582 punct ", ",Chat
R4632 T16584 T16582 conj GABA,Chat
R4633 T16585 T16584 punct ", ",GABA
R4634 T16586 T16584 conj Kcnc1b,GABA
R4635 T16587 T16586 punct ", ",Kcnc1b
R4636 T16588 T16586 conj Kcnc2,Kcnc1b
R4637 T16589 T16588 punct ", ",Kcnc2
R4638 T16590 T16588 cc and,Kcnc2
R4639 T16591 T16588 conj Sv2c,Kcnc2
R4640 T16592 T16565 prep at,rescued
R4641 T16593 T16594 amod multiple,times
R4642 T16594 T16592 pobj times,at
R4643 T16595 T16596 punct (,4A
R4644 T16596 T16565 parataxis 4A,rescued
R4645 T16597 T16596 compound Figure,4A
R4646 T16598 T16596 cc and,4A
R4647 T16599 T16600 nsubj data,shown
R4648 T16600 T16596 conj shown,4A
R4649 T16601 T16600 neg not,shown
R4650 T16602 T16600 punct ),shown
R4651 T16603 T16565 punct .,rescued
R4652 T16605 T16606 compound Rb,E2f3
R4653 T16606 T16608 compound E2f3,DKO
R4654 T16607 T16606 punct /,E2f3
R4655 T16608 T16609 compound DKO,SAC
R4656 T16609 T16610 compound SAC,tracks
R4657 T16610 T16611 nsubj tracks,were
R4658 T16612 T16613 advmod slightly,more
R4659 T16613 T16614 advmod more,disordered
R4660 T16614 T16611 acomp disordered,were
R4661 T16615 T16614 prep than,disordered
R4662 T16616 T16615 prep in,than
R4663 T16617 T16618 compound WT,retina
R4664 T16618 T16616 pobj retina,in
R4665 T16619 T16611 punct ", ",were
R4666 T16620 T16621 advmod most,likely
R4667 T16621 T16622 advmod likely,because
R4668 T16622 T16611 prep because,were
R4669 T16623 T16622 pcomp of,because
R4670 T16624 T16625 det the,absence
R4671 T16625 T16622 pobj absence,because
R4672 T16626 T16625 prep of,absence
R4673 T16627 T16628 amod synaptic,cells
R4674 T16628 T16626 pobj cells,of
R4675 T16629 T16628 compound partner,cells
R4676 T16630 T16628 punct ", ",cells
R4677 T16631 T16632 dep which,killed
R4678 T16632 T16628 relcl killed,cells
R4679 T16633 T16632 auxpass are,killed
R4680 T16634 T16632 agent by,killed
R4681 T16635 T16634 pobj E2f1,by
R4682 T16636 T16611 punct .,were
R4683 T16638 T16639 advmod Indeed,rescued
R4684 T16640 T16639 punct ", ",rescued
R4685 T16641 T16642 det this,defect
R4686 T16642 T16639 nsubjpass defect,rescued
R4687 T16643 T16642 amod minor,defect
R4688 T16644 T16639 auxpass was,rescued
R4689 T16645 T16639 prep in,rescued
R4690 T16646 T16647 det the,retina
R4691 T16647 T16645 pobj retina,in
R4692 T16648 T16649 nmod Rb,E2f3
R4693 T16649 T16653 nmod E2f3,knockout
R4694 T16650 T16649 punct /,E2f3
R4695 T16651 T16649 nmod E2f1,E2f3
R4696 T16652 T16649 punct /,E2f3
R4697 T16653 T16647 compound knockout,retina
R4698 T16654 T16653 amod triple,knockout
R4699 T16655 T16647 punct ", ",retina
R4700 T16656 T16657 advmod where,rescued
R4701 T16657 T16647 relcl rescued,retina
R4702 T16658 T16659 amod bipolar,cell
R4703 T16659 T16662 compound cell,death
R4704 T16660 T16658 cc and,bipolar
R4705 T16661 T16658 conj ganglion,bipolar
R4706 T16662 T16657 nsubjpass death,rescued
R4707 T16663 T16657 auxpass was,rescued
R4708 T16664 T16657 cc and,rescued
R4709 T16665 T16666 compound SAC,differentiation
R4710 T16666 T16667 nsubjpass differentiation,restored
R4711 T16667 T16657 conj restored,rescued
R4712 T16668 T16667 auxpass was,restored
R4713 T16669 T16670 punct (,4A
R4714 T16670 T16639 parataxis 4A,rescued
R4715 T16671 T16670 compound Figure,4A
R4716 T16672 T16670 punct ),4A
R4717 T16673 T16639 punct .,rescued
R4718 T16675 T16676 compound E2f3,deletion
R4719 T16676 T16677 nsubj deletion,affect
R4720 T16678 T16676 advmod alone,deletion
R4721 T16679 T16677 aux did,affect
R4722 T16680 T16677 neg not,affect
R4723 T16681 T16682 compound SAC,differentiation
R4724 T16682 T16677 dobj differentiation,affect
R4725 T16683 T16684 punct (,4A
R4726 T16684 T16677 parataxis 4A,affect
R4727 T16685 T16684 compound Figure,4A
R4728 T16686 T16684 punct ),4A
R4729 T16687 T16677 punct ;,affect
R4730 T16688 T16689 advmod thus,is
R4731 T16689 T16677 conj is,affect
R4732 T16690 T16689 punct ", ",is
R4733 T16691 T16689 nsubj it,is
R4734 T16692 T16693 amod unleashed,activity
R4735 T16693 T16689 attr activity,is
R4736 T16694 T16693 compound E2f3,activity
R4737 T16695 T16696 dep that,is
R4738 T16696 T16689 ccomp is,is
R4739 T16697 T16696 acomp detrimental,is
R4740 T16698 T16689 punct ", ",is
R4741 T16699 T16689 cc and,is
R4742 T16700 T16701 det the,role
R4743 T16701 T16703 nsubj role,is
R4744 T16702 T16701 amod critical,role
R4745 T16703 T16689 conj is,is
R4746 T16704 T16701 prep for,role
R4747 T16705 T16704 pobj Rb,for
R4748 T16706 T16707 aux to,inhibit
R4749 T16707 T16703 xcomp inhibit,is
R4750 T16708 T16707 dobj E2f3,inhibit
R4751 T16709 T16703 punct .,is
R4752 T16711 T16712 nsubj We,quantified
R4753 T16713 T16714 det the,fraction
R4754 T16714 T16712 dobj fraction,quantified
R4755 T16715 T16714 prep of,fraction
R4756 T16716 T16717 nmod Camk2a,SACs
R4757 T16717 T16715 pobj SACs,of
R4758 T16718 T16716 punct +,Camk2a
R4759 T16719 T16714 prep in,fraction
R4760 T16720 T16721 amod different,genotypes
R4761 T16721 T16719 pobj genotypes,in
R4762 T16722 T16712 cc and,quantified
R4763 T16723 T16712 conj found,quantified
R4764 T16724 T16725 mark that,expressed
R4765 T16725 T16723 ccomp expressed,found
R4766 T16726 T16727 nummod 60,%
R4767 T16727 T16725 nsubj %,expressed
R4768 T16728 T16727 prep of,%
R4769 T16729 T16730 nmod WT,cells
R4770 T16730 T16728 pobj cells,of
R4771 T16731 T16730 nmod P30,cells
R4772 T16732 T16730 nmod Camk2a,cells
R4773 T16733 T16732 punct +,Camk2a
R4774 T16734 T16725 dobj Chat,expressed
R4775 T16735 T16734 cc and,Chat
R4776 T16736 T16734 conj Slc18a3,Chat
R4777 T16737 T16725 punct ", ",expressed
R4778 T16738 T16739 dep which,dropped
R4779 T16739 T16725 ccomp dropped,expressed
R4780 T16740 T16739 prep to,dropped
R4781 T16741 T16742 advmod only,5.6
R4782 T16742 T16743 nummod 5.6,%
R4783 T16743 T16740 pobj %,to
R4784 T16744 T16739 prep in,dropped
R4785 T16745 T16746 det the,retina
R4786 T16746 T16744 pobj retina,in
R4787 T16747 T16748 compound Rb,KO
R4788 T16748 T16746 compound KO,retina
R4789 T16749 T16739 punct ", ",dropped
R4790 T16750 T16739 cc and,dropped
R4791 T16751 T16739 conj remained,dropped
R4792 T16752 T16751 acomp low,remained
R4793 T16753 T16751 prep at,remained
R4794 T16754 T16755 nummod 3.7,%
R4795 T16755 T16753 pobj %,at
R4796 T16756 T16751 prep in,remained
R4797 T16757 T16758 det the,retina
R4798 T16758 T16756 pobj retina,in
R4799 T16759 T16760 compound Rb,E2f1
R4800 T16760 T16762 compound E2f1,DKO
R4801 T16761 T16760 punct /,E2f1
R4802 T16762 T16758 compound DKO,retina
R4803 T16763 T16751 punct ", ",remained
R4804 T16764 T16751 cc but,remained
R4805 T16765 T16751 conj rose,remained
R4806 T16766 T16765 prep to,rose
R4807 T16767 T16768 nummod 91,%
R4808 T16768 T16766 pobj %,to
R4809 T16769 T16765 prep in,rose
R4810 T16770 T16771 det the,retina
R4811 T16771 T16769 pobj retina,in
R4812 T16772 T16773 compound Rb,E2f3
R4813 T16773 T16775 compound E2f3,DKO
R4814 T16774 T16773 punct /,E2f3
R4815 T16775 T16771 compound DKO,retina
R4816 T16776 T16777 punct (,4B
R4817 T16777 T16765 parataxis 4B,rose
R4818 T16778 T16777 compound Figure,4B
R4819 T16779 T16777 punct ),4B
R4820 T16780 T16712 punct .,quantified
R4821 T16782 T16783 det The,fraction
R4822 T16783 T16785 nsubj fraction,is
R4823 T16784 T16783 amod latter,fraction
R4824 T16786 T16785 acomp higher,is
R4825 T16787 T16786 prep than,higher
R4826 T16788 T16787 pobj WT,than
R4827 T16789 T16790 mark because,killed
R4828 T16790 T16785 advcl killed,is
R4829 T16791 T16792 compound ganglion,cells
R4830 T16792 T16790 nsubjpass cells,killed
R4831 T16793 T16792 punct ", ",cells
R4832 T16794 T16795 dep which,make
R4833 T16795 T16792 relcl make,cells
R4834 T16796 T16795 advmod normally,make
R4835 T16797 T16795 prt up,make
R4836 T16798 T16799 punct ~,40
R4837 T16799 T16800 nummod 40,%
R4838 T16800 T16795 dobj %,make
R4839 T16801 T16800 prep of,%
R4840 T16802 T16803 nmod Camk2a,cells
R4841 T16803 T16801 pobj cells,of
R4842 T16804 T16802 punct +,Camk2a
R4843 T16805 T16790 punct ", ",killed
R4844 T16806 T16790 auxpass are,killed
R4845 T16807 T16790 agent by,killed
R4846 T16808 T16807 pobj apoptosis,by
R4847 T16809 T16785 punct .,is
R4848 T16811 T16812 aux To,quantify
R4849 T16812 T16813 advcl quantify,exploited
R4850 T16814 T16815 det the,effect
R4851 T16815 T16812 dobj effect,quantify
R4852 T16816 T16815 prep of,effect
R4853 T16817 T16818 amod different,E2fs
R4854 T16818 T16816 pobj E2fs,of
R4855 T16819 T16815 prep on,effect
R4856 T16820 T16821 amod ectopic,division
R4857 T16821 T16819 pobj division,on
R4858 T16822 T16823 advmod specifically,in
R4859 T16823 T16815 prep in,effect
R4860 T16824 T16823 pobj SACs,in
R4861 T16825 T16813 punct ", ",exploited
R4862 T16826 T16813 nsubj we,exploited
R4863 T16827 T16813 dobj Isl1,exploited
R4864 T16828 T16827 punct (,Isl1
R4865 T16829 T16827 appos Islet1,Isl1
R4866 T16830 T16813 punct ),exploited
R4867 T16831 T16813 punct .,exploited
R4868 T16833 T16834 det This,marker
R4869 T16834 T16835 nsubjpass marker,expressed
R4870 T16835 T16837 ccomp expressed,are
R4871 T16836 T16835 auxpass is,expressed
R4872 T16838 T16835 prep in,expressed
R4873 T16839 T16840 preconj both,SACs
R4874 T16840 T16838 pobj SACs,in
R4875 T16841 T16840 cc and,SACs
R4876 T16842 T16843 compound ganglion,cells
R4877 T16843 T16840 conj cells,SACs
R4878 T16844 T16837 punct ", ",are
R4879 T16845 T16837 advmod thus,are
R4880 T16846 T16847 nmod Isl1,cells
R4881 T16847 T16837 nsubj cells,are
R4882 T16848 T16846 punct +,Isl1
R4883 T16849 T16847 prep in,cells
R4884 T16850 T16851 det the,INL
R4885 T16851 T16849 pobj INL,in
R4886 T16852 T16837 advmod exclusively,are
R4887 T16853 T16837 attr SACs,are
R4888 T16854 T16855 punct [,49
R4889 T16855 T16837 parataxis 49,are
R4890 T16856 T16855 punct ],49
R4891 T16857 T16837 punct .,are
R4892 T16859 T16860 nsubj We,found
R4893 T16861 T16862 mark that,were
R4894 T16862 T16860 ccomp were,found
R4895 T16863 T16864 nummod 98.2,%
R4896 T16864 T16862 nsubj %,were
R4897 T16865 T16864 punct ±,%
R4898 T16866 T16867 nummod 1.8,%
R4899 T16867 T16864 appos %,%
R4900 T16868 T16864 prep of,%
R4901 T16869 T16870 nmod Isl1,cells
R4902 T16870 T16868 pobj cells,of
R4903 T16871 T16869 punct +,Isl1
R4904 T16872 T16864 prep in,%
R4905 T16873 T16874 det the,INL
R4906 T16874 T16872 pobj INL,in
R4907 T16875 T16874 amod forming,INL
R4908 T16876 T16874 amod inner,INL
R4909 T16877 T16864 prep at,%
R4910 T16878 T16877 pobj P5,at
R4911 T16879 T16862 advmod also,were
R4912 T16880 T16862 attr Slc18a3,were
R4913 T16881 T16880 punct +,Slc18a3
R4914 T16882 T16860 punct ", ",found
R4915 T16883 T16860 advcl confirming,found
R4916 T16884 T16885 mark that,is
R4917 T16885 T16883 ccomp is,confirming
R4918 T16886 T16885 nsubj Isl1,is
R4919 T16887 T16888 det an,marker
R4920 T16888 T16885 attr marker,is
R4921 T16889 T16888 amod excellent,marker
R4922 T16890 T16888 compound SAC,marker
R4923 T16891 T16892 punct (,4C
R4924 T16892 T16885 parataxis 4C,is
R4925 T16893 T16892 compound Figure,4C
R4926 T16894 T16892 punct ),4C
R4927 T16895 T16860 punct .,found
R4928 T16897 T16898 advmod Moreover,is
R4929 T16899 T16898 punct ", ",is
R4930 T16900 T16898 nsubj Isl1,is
R4931 T16901 T16900 punct ", ",Isl1
R4932 T16902 T16900 prep unlike,Isl1
R4933 T16903 T16902 pobj Slc18a3,unlike
R4934 T16904 T16898 punct ", ",is
R4935 T16905 T16898 acomp nuclear,is
R4936 T16906 T16898 punct ", ",is
R4937 T16907 T16908 dep which,facilitates
R4938 T16908 T16898 advcl facilitates,is
R4939 T16909 T16908 dobj scoring,facilitates
R4940 T16910 T16909 prep of,scoring
R4941 T16911 T16912 nmod Isl1,cells
R4942 T16912 T16910 pobj cells,of
R4943 T16913 T16911 punct +,Isl1
R4944 T16914 T16911 punct /,Isl1
R4945 T16915 T16911 appos Mki67,Isl1
R4946 T16916 T16915 punct +,Mki67
R4947 T16917 T16898 punct .,is
R4948 T16919 T16920 nsubjpass It,expressed
R4949 T16920 T16923 ccomp expressed,study
R4950 T16921 T16920 auxpass is,expressed
R4951 T16922 T16920 advmod also,expressed
R4952 T16924 T16920 advmod earlier,expressed
R4953 T16925 T16924 prep than,earlier
R4954 T16926 T16925 pobj Slc18a3,than
R4955 T16927 T16920 punct ", ",expressed
R4956 T16928 T16920 advcl permitting,expressed
R4957 T16929 T16928 dobj analysis,permitting
R4958 T16930 T16929 prep of,analysis
R4959 T16931 T16930 pobj SACs,of
R4960 T16932 T16933 advmod soon,after
R4961 T16933 T16928 prep after,permitting
R4962 T16934 T16935 poss their,birth
R4963 T16935 T16933 pobj birth,after
R4964 T16936 T16935 prep at,birth
R4965 T16937 T16938 punct ~,E15
R4966 T16938 T16936 pobj E15,at
R4967 T16939 T16923 punct ;,study
R4968 T16940 T16923 advmod thus,study
R4969 T16941 T16923 punct ", ",study
R4970 T16942 T16923 nsubj we,study
R4971 T16943 T16923 aux could,study
R4972 T16944 T16923 dobj retina,study
R4973 T16945 T16923 prep at,study
R4974 T16946 T16945 pobj P0,at
R4975 T16947 T16946 punct ", ",P0
R4976 T16948 T16949 det a,time
R4977 T16949 T16946 appos time,P0
R4978 T16950 T16951 advmod when,is
R4979 T16951 T16949 relcl is,time
R4980 T16952 T16953 amod ectopic,division
R4981 T16953 T16951 nsubj division,is
R4982 T16954 T16951 acomp high,is
R4983 T16955 T16951 prep in,is
R4984 T16956 T16957 det the,retina
R4985 T16957 T16955 pobj retina,in
R4986 T16958 T16957 amod inner,retina
R4987 T16959 T16945 cc and,at
R4988 T16960 T16961 advmod prior,to
R4989 T16961 T16945 conj to,at
R4990 T16962 T16963 npadvmod Rb,independent
R4991 T16963 T16965 amod independent,exit
R4992 T16964 T16963 punct -,independent
R4993 T16965 T16961 pobj exit,to
R4994 T16966 T16967 compound cell,cycle
R4995 T16967 T16965 compound cycle,exit
R4996 T16968 T16965 acl associated,exit
R4997 T16969 T16968 prep with,associated
R4998 T16970 T16971 amod terminal,differentiation
R4999 T16971 T16969 pobj differentiation,with
R5000 T16972 T16973 punct [,2
R5001 T16973 T16923 parataxis 2,study
R5002 T16974 T16973 punct ],2
R5003 T16975 T16923 punct .,study
R5004 T16977 T16978 prep At,dividing
R5005 T16979 T16977 pobj P0,At
R5006 T16980 T16978 punct ", ",dividing
R5007 T16981 T16982 det no,cells
R5008 T16982 T16978 nsubj cells,dividing
R5009 T16983 T16982 nmod WT,cells
R5010 T16984 T16982 nmod Isl1,cells
R5011 T16985 T16984 punct +,Isl1
R5012 T16986 T16982 prep in,cells
R5013 T16987 T16988 det the,layer
R5014 T16988 T16986 pobj layer,in
R5015 T16989 T16988 amod inner,layer
R5016 T16990 T16988 amod neuroblastic,layer
R5017 T16991 T16988 punct (,layer
R5018 T16992 T16988 appos NBL,layer
R5019 T16993 T16988 punct ),layer
R5020 T16994 T16988 punct (,layer
R5021 T16995 T16996 dep which,is
R5022 T16996 T16988 relcl is,layer
R5023 T16997 T16998 det the,INL
R5024 T16998 T16996 attr INL,is
R5025 T16999 T16998 amod future,INL
R5026 T17000 T16978 punct ),dividing
R5027 T17001 T16978 aux were,dividing
R5028 T17002 T16978 punct ", ",dividing
R5029 T17003 T16978 cc but,dividing
R5030 T17004 T17005 quantmod 57,14
R5031 T17005 T17007 nummod 14,cells
R5032 T17006 T17005 punct ±,14
R5033 T17007 T17013 nsubjpass cells,detected
R5034 T17008 T17007 nmod Isl1,cells
R5035 T17009 T17008 punct +,Isl1
R5036 T17010 T17008 punct /,Isl1
R5037 T17011 T17008 appos Mki67,Isl1
R5038 T17012 T17011 punct +,Mki67
R5039 T17013 T16978 conj detected,dividing
R5040 T17014 T17013 auxpass were,detected
R5041 T17015 T17013 prep in,detected
R5042 T17016 T17017 det the,NBL
R5043 T17017 T17015 pobj NBL,in
R5044 T17018 T17019 nmod Rb,KO
R5045 T17019 T17017 nmod KO,NBL
R5046 T17020 T17017 amod inner,NBL
R5047 T17021 T17022 punct (,4D
R5048 T17022 T17013 parataxis 4D,detected
R5049 T17023 T17022 compound Figure,4D
R5050 T17024 T17022 punct ),4D
R5051 T17025 T17013 punct .,detected
R5052 T17027 T17028 advmod Indeed,dividing
R5053 T17029 T17028 punct ", ",dividing
R5054 T17030 T17031 quantmod about,one
R5055 T17031 T17028 nsubj one,dividing
R5056 T17032 T17031 punct -,one
R5057 T17033 T17031 quantmod third,one
R5058 T17034 T17031 prep of,one
R5059 T17035 T17036 det all,cells
R5060 T17036 T17034 pobj cells,of
R5061 T17037 T17036 nmod Isl1,cells
R5062 T17038 T17037 punct +,Isl1
R5063 T17039 T17031 prep in,one
R5064 T17040 T17041 det the,NBL
R5065 T17041 T17039 pobj NBL,in
R5066 T17042 T17041 amod entire,NBL
R5067 T17043 T17041 amod inner,NBL
R5068 T17044 T17028 aux were,dividing
R5069 T17045 T17028 prep in,dividing
R5070 T17046 T17047 det the,retina
R5071 T17047 T17045 pobj retina,in
R5072 T17048 T17049 compound Rb,KO
R5073 T17049 T17047 compound KO,retina
R5074 T17050 T17028 punct ", ",dividing
R5075 T17051 T17028 cc or,dividing
R5076 T17052 T17053 punct ~,50
R5077 T17053 T17054 nummod 50,%
R5078 T17054 T17028 conj %,dividing
R5079 T17055 T17054 prep in,%
R5080 T17056 T17057 det the,periphery
R5081 T17057 T17055 pobj periphery,in
R5082 T17058 T17059 advmod where,expressed
R5083 T17059 T17057 relcl expressed,periphery
R5084 T17060 T17059 nsubjpass Cre,expressed
R5085 T17061 T17059 auxpass is,expressed
R5086 T17062 T17063 punct (,4E
R5087 T17063 T17054 parataxis 4E,%
R5088 T17064 T17063 compound Figure,4E
R5089 T17065 T17063 cc and,4E
R5090 T17066 T17067 nsubj data,shown
R5091 T17067 T17063 conj shown,4E
R5092 T17068 T17067 neg not,shown
R5093 T17069 T17067 punct ),shown
R5094 T17070 T17054 punct .,%
R5095 T17072 T17073 det This,defect
R5096 T17073 T17074 nsubjpass defect,suppressed
R5097 T17075 T17074 auxpass was,suppressed
R5098 T17076 T17074 prep in,suppressed
R5099 T17077 T17078 det the,retina
R5100 T17078 T17076 pobj retina,in
R5101 T17079 T17080 compound Rb,E2f1
R5102 T17080 T17082 compound E2f1,DKO
R5103 T17081 T17080 punct /,E2f1
R5104 T17082 T17078 compound DKO,retina
R5105 T17083 T17078 punct ", ",retina
R5106 T17084 T17085 advmod where,detected
R5107 T17085 T17078 relcl detected,retina
R5108 T17086 T17085 nsubj we,detected
R5109 T17087 T17088 advmod only,1
R5110 T17088 T17091 nummod 1,SAC
R5111 T17089 T17088 quantmod 1,1
R5112 T17090 T17088 punct ±,1
R5113 T17091 T17085 dobj SAC,detected
R5114 T17092 T17091 compound dividing,SAC
R5115 T17093 T17078 punct ", ",retina
R5116 T17094 T17078 cc but,retina
R5117 T17095 T17094 neg not,but
R5118 T17096 T17097 det the,retina
R5119 T17097 T17078 conj retina,retina
R5120 T17098 T17099 compound Rb,E2f3
R5121 T17099 T17101 compound E2f3,DKO
R5122 T17100 T17099 punct /,E2f3
R5123 T17101 T17097 compound DKO,retina
R5124 T17102 T17097 punct ", ",retina
R5125 T17103 T17104 advmod where,were
R5126 T17104 T17097 relcl were,retina
R5127 T17105 T17104 expl there,were
R5128 T17106 T17107 quantmod 53,8
R5129 T17107 T17109 nummod 8,SACs
R5130 T17108 T17107 punct ±,8
R5131 T17109 T17104 attr SACs,were
R5132 T17110 T17109 amod dividing,SACs
R5133 T17111 T17112 punct (,4D
R5134 T17112 T17104 parataxis 4D,were
R5135 T17113 T17112 compound Figure,4D
R5136 T17114 T17112 cc and,4D
R5137 T17115 T17112 conj 4E,4D
R5138 T17116 T17112 punct ),4D
R5139 T17117 T17074 punct .,suppressed
R5140 T17119 T17120 nsubj We,observed
R5141 T17121 T17122 amod similar,effects
R5142 T17122 T17120 dobj effects,observed
R5143 T17123 T17120 prep at,observed
R5144 T17124 T17123 pobj P0,at
R5145 T17125 T17120 prep with,observed
R5146 T17126 T17125 pobj Calb2,with
R5147 T17127 T17126 punct ", ",Calb2
R5148 T17128 T17129 dep which,marks
R5149 T17129 T17126 relcl marks,Calb2
R5150 T17130 T17131 amod newborn,SACs
R5151 T17131 T17129 dobj SACs,marks
R5152 T17132 T17131 cc and,SACs
R5153 T17133 T17134 amod other,cells
R5154 T17134 T17131 conj cells,SACs
R5155 T17135 T17134 amod amacrine,cells
R5156 T17136 T17137 punct (,shown
R5157 T17137 T17120 parataxis shown,observed
R5158 T17138 T17137 nsubj data,shown
R5159 T17139 T17137 neg not,shown
R5160 T17140 T17137 punct ),shown
R5161 T17141 T17120 punct .,observed
R5162 T17143 T17144 advmod Thus,suppresses
R5163 T17145 T17144 punct ", ",suppresses
R5164 T17146 T17144 prep in,suppresses
R5165 T17147 T17148 compound Rb,KO
R5166 T17148 T17149 compound KO,SACs
R5167 T17149 T17146 pobj SACs,in
R5168 T17150 T17144 punct ", ",suppresses
R5169 T17151 T17152 compound E2f1,deletion
R5170 T17152 T17144 nsubj deletion,suppresses
R5171 T17153 T17154 amod ectopic,division
R5172 T17154 T17144 dobj division,suppresses
R5173 T17155 T17154 cc but,division
R5174 T17156 T17155 neg not,but
R5175 T17157 T17158 amod aberrant,differentiation
R5176 T17158 T17154 conj differentiation,division
R5177 T17159 T17144 punct ", ",suppresses
R5178 T17160 T17161 mark whereas,suppresses
R5179 T17161 T17144 advcl suppresses,suppresses
R5180 T17162 T17163 compound E2f3,deletion
R5181 T17163 T17161 nsubj deletion,suppresses
R5182 T17164 T17165 amod aberrant,differentiation
R5183 T17165 T17161 dobj differentiation,suppresses
R5184 T17166 T17165 cc but,differentiation
R5185 T17167 T17166 neg not,but
R5186 T17168 T17169 amod ectopic,division
R5187 T17169 T17165 conj division,differentiation
R5188 T17170 T17144 punct .,suppresses

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T16228 0-2 PR_EXT:000013773 denotes Rb
T16229 3-12 GO:0065007 denotes Regulates
T16230 17-32 GO_RO_EXT:developmental_differentiation_process denotes Differentiation
T16231 41-45 PR_EXT:000006854 denotes E2f3
T16232 46-48 PR_EXT:000013773 denotes Rb
T16233 49-54 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T16234 69-77 CHEBI_PR_EXT:protein denotes proteins
T16235 99-107 CL:0000540 denotes neuronal
T16236 108-113 CL_GO_EXT:cell denotes cells
T16237 123-138 UBERON_EXT:skeletal_muscle_organ_or_tissue denotes skeletal muscle
T16238 140-150 CL:0000136 denotes adipocytes
T16239 156-160 UBERON_EXT:bone_element_or_tissue denotes bone
T16240 162-164 PR_EXT:000013773 denotes Rb
T16241 179-183 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T16242 199-205 UBERON:0000479 denotes tissue
T16243 215-228 GO_EXT:transcription denotes transcription
T16244 215-236 GO_EXT:transcription_factor denotes transcription factors
T16245 250-265 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16246 298-300 PR_EXT:000013773 denotes Rb
T16247 321-327 UBERON:0000966 denotes retina
T16248 363-378 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16249 398-401 PR_EXT:E2F denotes E2f
T16250 415-417 PR_EXT:000013773 denotes Rb
T16251 428-443 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16252 468-472 CL_GO_EXT:cell denotes cell
T16253 468-478 GO:0007049 denotes cell cycle
T16254 468-472 _FRAGMENT denotes cell
T16255 482-487 GO:0008219 denotes death
T16256 550-553 PR_EXT:E2F denotes E2f
T16257 558-566 GO:0065007 denotes regulate
T16258 572-587 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16259 588-593 SO_EXT:0000704 denotes genes
T16260 627-631 PR_EXT:000006853 denotes E2f2
T16261 635-639 PR_EXT:000006854 denotes E2f3
T16262 654-656 PR_EXT:000013773 denotes Rb
T16263 664-674 GO_PATO_EXT:biological_maturation denotes maturation
T16264 701-705 PR_EXT:000006852 denotes E2f1
T16265 706-714 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T16266 734-741 GO:0007067 denotes mitosis
T16267 748-753 CL_GO_EXT:cell denotes cells
T16268 796-800 PR_EXT:000006853 denotes E2f2
T16269 801-809 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T16270 875-879 PR_EXT:000006854 denotes E2f3
T16271 880-888 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T16272 913-920 GO:0007067 denotes mitosis
T16273 925-932 SO_EXT:sequence_rescue_process denotes rescued
T16274 933-938 PR_EXT:000004968 denotes Calb2
T16275 940-947 PR_EXT:000014968 denotes Slc18a3
T16276 949-953 GO_PR_EXT:choline_O_acetyltransferase denotes Chat
T16277 955-959 CHEBI:16865 denotes GABA
T16278 961-967 PR_EXT:000000940 denotes Kcnc1b
T16279 969-974 PR_EXT:000000782 denotes Kcnc2
T16280 980-984 PR_EXT:000015851 denotes Sv2c
T16281 1044-1046 PR_EXT:000013773 denotes Rb
T16282 1047-1051 PR_EXT:000006854 denotes E2f3
T16283 1105-1107 SO_EXT:wild_type_entity_or_quality denotes WT
T16284 1108-1114 UBERON:0000966 denotes retina
T16285 1154-1162 GO:0045202 denotes synaptic
T16286 1171-1176 CL_GO_EXT:cell denotes cells
T16287 1188-1194 GO_EXT:killing denotes killed
T16288 1198-1202 PR_EXT:000006852 denotes E2f1
T16289 1234-1241 SO_EXT:sequence_rescue_process denotes rescued
T16290 1249-1251 PR_EXT:000013773 denotes Rb
T16291 1252-1256 PR_EXT:000006852 denotes E2f1
T16292 1257-1261 PR_EXT:000006854 denotes E2f3
T16293 1278-1284 UBERON:0000966 denotes retina
T16294 1292-1299 _FRAGMENT denotes bipolar
T16295 1313-1317 CL:0000103 denotes cell
T16296 1304-1312 UBERON:0000045 denotes ganglion
T16297 1304-1317 CL:0000740 denotes ganglion cell
T16298 1313-1317 CL_GO_EXT:cell denotes cell
T16299 1313-1323 GO:0008219 denotes cell death
T16300 1328-1335 SO_EXT:sequence_rescue_process denotes rescued
T16301 1344-1359 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16302 1386-1390 PR_EXT:000006854 denotes E2f3
T16303 1391-1399 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T16304 1425-1440 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16305 1476-1480 PR_EXT:000006854 denotes E2f3
T16306 1537-1539 PR_EXT:000013773 denotes Rb
T16307 1554-1558 PR_EXT:000006854 denotes E2f3
T16308 1590-1596 PR_EXT:000003199 denotes Camk2a
T16309 1616-1625 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T16310 1648-1650 SO_EXT:wild_type_entity_or_quality denotes WT
T16311 1655-1661 PR_EXT:000003199 denotes Camk2a
T16312 1663-1668 CL_GO_EXT:cell denotes cells
T16313 1669-1678 GO:0010467 denotes expressed
T16314 1679-1683 GO_PR_EXT:choline_O_acetyltransferase denotes Chat
T16315 1688-1695 PR_EXT:000014968 denotes Slc18a3
T16316 1731-1733 PR_EXT:000013773 denotes Rb
T16317 1737-1743 UBERON:0000966 denotes retina
T16318 1777-1779 PR_EXT:000013773 denotes Rb
T16319 1780-1784 PR_EXT:000006852 denotes E2f1
T16320 1789-1795 UBERON:0000966 denotes retina
T16321 1820-1822 PR_EXT:000013773 denotes Rb
T16322 1823-1827 PR_EXT:000006854 denotes E2f3
T16323 1832-1838 UBERON:0000966 denotes retina
T16324 1887-1889 SO_EXT:wild_type_entity_or_quality denotes WT
T16325 1898-1906 UBERON:0000045 denotes ganglion
T16326 1898-1912 CL:0000740 denotes ganglion cells
T16327 1907-1912 CL_GO_EXT:cell denotes cells
T16328 1945-1951 PR_EXT:000003199 denotes Camk2a
T16329 1953-1958 CL_GO_EXT:cell denotes cells
T16330 1964-1970 GO_EXT:killing denotes killed
T16331 1974-1983 GO:0006915 denotes apoptosis
T16332 2021-2025 PR_EXT:E2F denotes E2fs
T16333 2081-2085 PR_EXT:000009116 denotes Isl1
T16334 2087-2093 PR_EXT:000009116 denotes Islet1
T16335 2101-2107 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T16336 2111-2120 GO:0010467 denotes expressed
T16337 2138-2146 UBERON:0000045 denotes ganglion
T16338 2138-2152 CL:0000740 denotes ganglion cells
T16339 2147-2152 CL_GO_EXT:cell denotes cells
T16340 2159-2163 PR_EXT:000009116 denotes Isl1
T16341 2165-2170 CL_GO_EXT:cell denotes cells
T16342 2178-2181 UBERON:0001791 denotes INL
T16343 2239-2243 PR_EXT:000009116 denotes Isl1
T16344 2245-2250 CL_GO_EXT:cell denotes cells
T16345 2272-2275 UBERON:0001791 denotes INL
T16346 2292-2299 PR_EXT:000014968 denotes Slc18a3
T16347 2318-2322 PR_EXT:000009116 denotes Isl1
T16348 2343-2349 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T16349 2373-2377 PR_EXT:000009116 denotes Isl1
T16350 2386-2393 PR_EXT:000014968 denotes Slc18a3
T16351 2398-2405 GO:0005634 denotes nuclear
T16352 2436-2440 PR_EXT:000009116 denotes Isl1
T16353 2442-2447 PR_EXT:000010425 denotes Mki67
T16354 2449-2454 CL_GO_EXT:cell denotes cells
T16355 2467-2476 GO:0010467 denotes expressed
T16356 2490-2497 PR_EXT:000014968 denotes Slc18a3
T16357 2580-2586 UBERON:0000966 denotes retina
T16358 2644-2650 UBERON:0000966 denotes retina
T16359 2664-2666 PR_EXT:000013773 denotes Rb
T16360 2679-2683 CL_GO_EXT:cell denotes cell
T16361 2679-2689 GO:0007049 denotes cell cycle
T16362 2720-2735 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16363 2751-2753 SO_EXT:wild_type_entity_or_quality denotes WT
T16364 2754-2758 PR_EXT:000009116 denotes Isl1
T16365 2760-2765 CL_GO_EXT:cell denotes cells
T16366 2779-2791 CL:0000031 denotes neuroblastic
T16367 2825-2828 UBERON:0001791 denotes INL
T16368 2857-2861 PR_EXT:000009116 denotes Isl1
T16369 2863-2868 PR_EXT:000010425 denotes Mki67
T16370 2870-2875 CL_GO_EXT:cell denotes cells
T16371 2897-2899 PR_EXT:000013773 denotes Rb
T16372 2957-2961 PR_EXT:000009116 denotes Isl1
T16373 2963-2968 CL_GO_EXT:cell denotes cells
T16374 3014-3016 PR_EXT:000013773 denotes Rb
T16375 3020-3026 UBERON:0000966 denotes retina
T16376 3066-3075 GO:0010467 denotes expressed
T16377 3142-3144 PR_EXT:000013773 denotes Rb
T16378 3145-3149 PR_EXT:000006852 denotes E2f1
T16379 3154-3160 UBERON:0000966 denotes retina
T16380 3217-3219 PR_EXT:000013773 denotes Rb
T16381 3220-3224 PR_EXT:000006854 denotes E2f3
T16382 3229-3235 UBERON:0000966 denotes retina
T16383 3334-3339 PR_EXT:000004968 denotes Calb2
T16384 3347-3352 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes marks
T16385 3376-3390 CL:0000561 denotes amacrine cells
T16386 3385-3390 CL_GO_EXT:cell denotes cells
T16387 3418-3420 PR_EXT:000013773 denotes Rb
T16388 3430-3434 PR_EXT:000006852 denotes E2f1
T16389 3435-3443 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T16390 3489-3504 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T16391 3514-3518 PR_EXT:000006854 denotes E2f3
T16392 3519-3527 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T16393 3548-3563 GO_RO_EXT:developmental_differentiation_process denotes differentiation
R4451 T16255 T16254 _lexicallyChainedTo death,cell
R4452 T16295 T16294 _lexicallyChainedTo cell,bipolar

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T16158 1257-1261 PR:000006854 denotes E2f3
T16159 1278-1284 UBERON:0000966 denotes retina
T16160 1292-1299 _FRAGMENT denotes bipolar
T16161 1313-1317 CL:0000103 denotes cell
T16162 1304-1312 UBERON:0000045 denotes ganglion
T16163 1304-1317 CL:0000740 denotes ganglion cell
T16164 1313-1323 GO:0008219 denotes cell death
T16165 1386-1390 PR:000006854 denotes E2f3
T16166 1476-1480 PR:000006854 denotes E2f3
T16167 1537-1539 PR:000013773 denotes Rb
T16120 0-2 PR:000013773 denotes Rb
T16121 3-12 GO:0065007 denotes Regulates
T16122 41-45 PR:000006854 denotes E2f3
T16123 46-48 PR:000013773 denotes Rb
T16124 99-107 CL:0000540 denotes neuronal
T16125 123-131 UBERON:0004288 denotes skeletal
T16126 140-150 CL:0000136 denotes adipocytes
T16127 162-164 PR:000013773 denotes Rb
T16128 199-205 UBERON:0000479 denotes tissue
T16129 298-300 PR:000013773 denotes Rb
T16130 321-327 UBERON:0000966 denotes retina
T16131 415-417 PR:000013773 denotes Rb
T16132 468-478 GO:0007049 denotes cell cycle
T16133 468-472 _FRAGMENT denotes cell
T16134 482-487 GO:0008219 denotes death
T16135 558-566 GO:0065007 denotes regulate
T16136 588-593 SO:0000704 denotes genes
T16137 627-631 PR:000006853 denotes E2f2
T16138 635-639 PR:000006854 denotes E2f3
T16139 654-656 PR:000013773 denotes Rb
T16140 701-705 PR:000006852 denotes E2f1
T16141 734-741 GO:0007067 denotes mitosis
T16142 796-800 PR:000006853 denotes E2f2
T16143 875-879 PR:000006854 denotes E2f3
T16144 913-920 GO:0007067 denotes mitosis
T16145 933-938 PR:000004968 denotes Calb2
T16146 940-947 PR:000014968 denotes Slc18a3
T16147 955-959 CHEBI:16865 denotes GABA
T16148 961-967 PR:000000940 denotes Kcnc1b
T16149 969-974 PR:000000782 denotes Kcnc2
T16150 980-984 PR:000015851 denotes Sv2c
T16151 1044-1046 PR:000013773 denotes Rb
T16152 1047-1051 PR:000006854 denotes E2f3
T16153 1108-1114 UBERON:0000966 denotes retina
T16154 1154-1162 GO:0045202 denotes synaptic
T16155 1198-1202 PR:000006852 denotes E2f1
T16156 1249-1251 PR:000013773 denotes Rb
T16157 1252-1256 PR:000006852 denotes E2f1
T16168 1554-1558 PR:000006854 denotes E2f3
T16169 1590-1596 PR:000003199 denotes Camk2a
T16170 1655-1661 PR:000003199 denotes Camk2a
T16171 1669-1678 GO:0010467 denotes expressed
T16172 1688-1695 PR:000014968 denotes Slc18a3
T16173 1731-1733 PR:000013773 denotes Rb
T16174 1737-1743 UBERON:0000966 denotes retina
T16175 1777-1779 PR:000013773 denotes Rb
T16176 1780-1784 PR:000006852 denotes E2f1
T16177 1789-1795 UBERON:0000966 denotes retina
T16178 1820-1822 PR:000013773 denotes Rb
T16179 1823-1827 PR:000006854 denotes E2f3
T16180 1832-1838 UBERON:0000966 denotes retina
T16181 1898-1906 UBERON:0000045 denotes ganglion
T16182 1898-1912 CL:0000740 denotes ganglion cells
T16183 1945-1951 PR:000003199 denotes Camk2a
T16184 1974-1983 GO:0006915 denotes apoptosis
T16185 2081-2085 PR:000009116 denotes Isl1
T16186 2087-2093 PR:000009116 denotes Islet1
T16187 2111-2120 GO:0010467 denotes expressed
T16188 2138-2146 UBERON:0000045 denotes ganglion
T16189 2138-2152 CL:0000740 denotes ganglion cells
T16190 2159-2163 PR:000009116 denotes Isl1
T16191 2178-2181 UBERON:0001791 denotes INL
T16192 2239-2243 PR:000009116 denotes Isl1
T16193 2272-2275 UBERON:0001791 denotes INL
T16194 2292-2299 PR:000014968 denotes Slc18a3
T16195 2318-2322 PR:000009116 denotes Isl1
T16196 2373-2377 PR:000009116 denotes Isl1
T16197 2386-2393 PR:000014968 denotes Slc18a3
T16198 2398-2405 GO:0005634 denotes nuclear
T16199 2436-2440 PR:000009116 denotes Isl1
T16200 2442-2447 PR:000010425 denotes Mki67
T16201 2467-2476 GO:0010467 denotes expressed
T16202 2490-2497 PR:000014968 denotes Slc18a3
T16203 2580-2586 UBERON:0000966 denotes retina
T16204 2644-2650 UBERON:0000966 denotes retina
T16205 2664-2666 PR:000013773 denotes Rb
T16206 2679-2689 GO:0007049 denotes cell cycle
T16207 2754-2758 PR:000009116 denotes Isl1
T16208 2779-2791 CL:0000031 denotes neuroblastic
T16209 2825-2828 UBERON:0001791 denotes INL
T16210 2857-2861 PR:000009116 denotes Isl1
T16211 2863-2868 PR:000010425 denotes Mki67
T16212 2897-2899 PR:000013773 denotes Rb
T16213 2957-2961 PR:000009116 denotes Isl1
T16214 3014-3016 PR:000013773 denotes Rb
T16215 3020-3026 UBERON:0000966 denotes retina
T16216 3066-3075 GO:0010467 denotes expressed
T16217 3142-3144 PR:000013773 denotes Rb
T16218 3145-3149 PR:000006852 denotes E2f1
T16219 3154-3160 UBERON:0000966 denotes retina
T16220 3217-3219 PR:000013773 denotes Rb
T16221 3220-3224 PR:000006854 denotes E2f3
T16222 3229-3235 UBERON:0000966 denotes retina
T16223 3334-3339 PR:000004968 denotes Calb2
T16224 3376-3390 CL:0000561 denotes amacrine cells
T16225 3418-3420 PR:000013773 denotes Rb
T16226 3430-3434 PR:000006852 denotes E2f1
T16227 3514-3518 PR:000006854 denotes E2f3
R4449 T16134 T16133 _lexicallyChainedTo death,cell
R4450 T16161 T16160 _lexicallyChainedTo cell,bipolar

2_test

Id Subject Object Predicate Lexical cue
17608565-11447760-84868995 79-81 11447760 denotes 43
17608565-8381715-84868996 267-269 8381715 denotes 31
17608565-11545733-84868996 267-269 11545733 denotes 31
17608565-8946919-84868996 267-269 8946919 denotes 31
17608565-11159908-84868997 595-597 11159908 denotes 44
17608565-12110166-84868997 595-597 12110166 denotes 44
17608565-12975318-84868997 595-597 12975318 denotes 44
17608565-15479636-84868997 595-597 15479636 denotes 44
17608565-16081278-84868997 595-597 16081278 denotes 44
17608565-9315903-84868998 2204-2206 9315903 denotes 49
17608565-15193257-84868999 2737-2738 15193257 denotes 2
T27346 79-81 11447760 denotes 43
T67368 267-269 8381715 denotes 31
T65967 267-269 11545733 denotes 31
T79277 267-269 8946919 denotes 31
T48689 595-597 11159908 denotes 44
T1759 595-597 12110166 denotes 44
T21385 595-597 12975318 denotes 44
T89101 595-597 15479636 denotes 44
T28753 595-597 16081278 denotes 44
T59642 2204-2206 9315903 denotes 49
T26396 2737-2738 15193257 denotes 2