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(photopic) recordings to specifically assess the cone system yielded comparable results. Cones represent only 3% of photoreceptors and, unlike rods, develop without Rb, but they require rods for survival, and in the Rb KO retina, they have abnormal morphology and their synaptic targets, bipolar cells, are much depleted [2]. The photopic response, a product of cone and mainly bipolar activity, was much reduced by Rb loss, but was rescued considerably in the Rb/E2f1 DKO retina (Figure S5). Again, the median amplitude lay at the lower end of the E2f1 KO range. The photopic response in E2f1 KO mice was slightly reduced relative to WT (Figure S5B), possibly because E2f1 is required for maximal expansion of embryonic RPCs, and the E2f1 KO retina has, as noted earlier, slightly fewer cells than the WT retina, although cell type proportions are unaffected (D. C. and R. B., unpublished data). Thus, marginally subnormal photopic responses in the Rb/E2f1 DKO retina can be attributed to both a reduction of cone numbers in E2f1 KO mice alone, and a “genuine” slight reduction in cone function attributable to Rb loss relative to WT. This slight effect may relate to a true differentiation defect in a subset of amacrine cells discussed below. This discussion should not obscure the major outcome that E2f1 deletion recovers most of the ERG response. Thus, E2f1 deletion not only rescues morphology but also both rod and cone system function in the Rb KO retina."}

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Cones represent only 3% of photoreceptors and, unlike rods, develop without Rb, but they require rods for survival, and in the Rb KO retina, they have abnormal morphology and their synaptic targets, bipolar cells, are much depleted [2]. The photopic response, a product of cone and mainly bipolar activity, was much reduced by Rb loss, but was rescued considerably in the Rb/E2f1 DKO retina (Figure S5). Again, the median amplitude lay at the lower end of the E2f1 KO range. The photopic response in E2f1 KO mice was slightly reduced relative to WT (Figure S5B), possibly because E2f1 is required for maximal expansion of embryonic RPCs, and the E2f1 KO retina has, as noted earlier, slightly fewer cells than the WT retina, although cell type proportions are unaffected (D. C. and R. B., unpublished data). Thus, marginally subnormal photopic responses in the Rb/E2f1 DKO retina can be attributed to both a reduction of cone numbers in E2f1 KO mice alone, and a “genuine” slight reduction in cone function attributable to Rb loss relative to WT. This slight effect may relate to a true differentiation defect in a subset of amacrine cells discussed below. This discussion should not obscure the major outcome that E2f1 deletion recovers most of the ERG response. Thus, E2f1 deletion not only rescues morphology but also both rod and cone system function in the Rb KO retina."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T10854","span":{"begin":0,"end":13},"obj":"GO:0036367"},{"id":"T10855","span":{"begin":15,"end":23},"obj":"GO:0036367"},{"id":"T10856","span":{"begin":63,"end":67},"obj":"CL:0000573"},{"id":"T10857","span":{"begin":103,"end":108},"obj":"CL:0000573"},{"id":"T10858","span":{"begin":130,"end":144},"obj":"CL:0000210"},{"id":"T10859","span":{"begin":157,"end":161},"obj":"CL:0000604"},{"id":"T10860","span":{"begin":179,"end":181},"obj":"PR:000013773"},{"id":"T10861","span":{"begin":200,"end":204},"obj":"CL:0000604"},{"id":"T10862","span":{"begin":230,"end":232},"obj":"PR:000013773"},{"id":"T10863","span":{"begin":236,"end":242},"obj":"UBERON:0000966"},{"id":"T10864","span":{"begin":284,"end":292},"obj":"GO:0045202"},{"id":"T10865","span":{"begin":302,"end":315},"obj":"CL:0000103"},{"id":"T10866","span":{"begin":344,"end":361},"obj":"GO:0036367"},{"id":"T10867","span":{"begin":376,"end":380},"obj":"CL:0000573"},{"id":"T10868","span":{"begin":392,"end":399},"obj":"CL:0000103"},{"id":"T10869","span":{"begin":430,"end":432},"obj":"PR:000013773"},{"id":"T10870","span":{"begin":475,"end":477},"obj":"PR:000013773"},{"id":"T10871","span":{"begin":478,"end":482},"obj":"PR:000006852"},{"id":"T10872","span":{"begin":487,"end":493},"obj":"UBERON:0000966"},{"id":"T10873","span":{"begin":563,"end":567},"obj":"PR:000006852"},{"id":"T10874","span":{"begin":582,"end":599},"obj":"GO:0036367"},{"id":"T10875","span":{"begin":603,"end":607},"obj":"PR:000006852"},{"id":"T10876","span":{"begin":611,"end":615},"obj":"NCBITaxon:10088"},{"id":"T10877","span":{"begin":683,"end":687},"obj":"PR:000006852"},{"id":"T10878","span":{"begin":725,"end":734},"obj":"UBERON:0000922"},{"id":"T10879","span":{"begin":735,"end":739},"obj":"CL:0002672"},{"id":"T10880","span":{"begin":749,"end":753},"obj":"PR:000006852"},{"id":"T10881","span":{"begin":757,"end":763},"obj":"UBERON:0000966"},{"id":"T10882","span":{"begin":820,"end":826},"obj":"UBERON:0000966"},{"id":"T10883","span":{"begin":938,"end":956},"obj":"GO:0036367"},{"id":"T10884","span":{"begin":964,"end":966},"obj":"PR:000013773"},{"id":"T10885","span":{"begin":967,"end":971},"obj":"PR:000006852"},{"id":"T10886","span":{"begin":976,"end":982},"obj":"UBERON:0000966"},{"id":"T10887","span":{"begin":1024,"end":1028},"obj":"CL:0000573"},{"id":"T10888","span":{"begin":1040,"end":1044},"obj":"PR:000006852"},{"id":"T10889","span":{"begin":1048,"end":1052},"obj":"NCBITaxon:10088"},{"id":"T10890","span":{"begin":1096,"end":1100},"obj":"CL:0000573"},{"id":"T10891","span":{"begin":1126,"end":1128},"obj":"PR:000013773"},{"id":"T10892","span":{"begin":1228,"end":1242},"obj":"CL:0000561"},{"id":"T10893","span":{"begin":1318,"end":1322},"obj":"PR:000006852"},{"id":"T10894","span":{"begin":1373,"end":1377},"obj":"PR:000006852"},{"id":"T10895","span":{"begin":1429,"end":1432},"obj":"CL:0000604"},{"id":"T10896","span":{"begin":1437,"end":1441},"obj":"CL:0000573"},{"id":"T10897","span":{"begin":1465,"end":1467},"obj":"PR:000013773"},{"id":"T10898","span":{"begin":1471,"end":1477},"obj":"UBERON:0000966"}],"text":"Light-adapted (photopic) recordings to specifically assess the cone system yielded comparable results. Cones represent only 3% of photoreceptors and, unlike rods, develop without Rb, but they require rods for survival, and in the Rb KO retina, they have abnormal morphology and their synaptic targets, bipolar cells, are much depleted [2]. The photopic response, a product of cone and mainly bipolar activity, was much reduced by Rb loss, but was rescued considerably in the Rb/E2f1 DKO retina (Figure S5). Again, the median amplitude lay at the lower end of the E2f1 KO range. The photopic response in E2f1 KO mice was slightly reduced relative to WT (Figure S5B), possibly because E2f1 is required for maximal expansion of embryonic RPCs, and the E2f1 KO retina has, as noted earlier, slightly fewer cells than the WT retina, although cell type proportions are unaffected (D. C. and R. B., unpublished data). Thus, marginally subnormal photopic responses in the Rb/E2f1 DKO retina can be attributed to both a reduction of cone numbers in E2f1 KO mice alone, and a “genuine” slight reduction in cone function attributable to Rb loss relative to WT. This slight effect may relate to a true differentiation defect in a subset of amacrine cells discussed below. This discussion should not obscure the major outcome that E2f1 deletion recovers most of the ERG response. Thus, E2f1 deletion not only rescues morphology but also both rod and cone system function in the Rb KO retina."}

{"project":"2_test","denotations":[{"id":"17608565-15193257-84868981","span":{"begin":336,"end":337},"obj":"15193257"},{"id":"T30099","span":{"begin":336,"end":337},"obj":"15193257"}],"text":"Light-adapted (photopic) recordings to specifically assess the cone system yielded comparable results. Cones represent only 3% of photoreceptors and, unlike rods, develop without Rb, but they require rods for survival, and in the Rb KO retina, they have abnormal morphology and their synaptic targets, bipolar cells, are much depleted [2]. The photopic response, a product of cone and mainly bipolar activity, was much reduced by Rb loss, but was rescued considerably in the Rb/E2f1 DKO retina (Figure S5). Again, the median amplitude lay at the lower end of the E2f1 KO range. The photopic response in E2f1 KO mice was slightly reduced relative to WT (Figure S5B), possibly because E2f1 is required for maximal expansion of embryonic RPCs, and the E2f1 KO retina has, as noted earlier, slightly fewer cells than the WT retina, although cell type proportions are unaffected (D. C. and R. B., unpublished data). Thus, marginally subnormal photopic responses in the Rb/E2f1 DKO retina can be attributed to both a reduction of cone numbers in E2f1 KO mice alone, and a “genuine” slight reduction in cone function attributable to Rb loss relative to WT. This slight effect may relate to a true differentiation defect in a subset of amacrine cells discussed below. This discussion should not obscure the major outcome that E2f1 deletion recovers most of the ERG response. Thus, E2f1 deletion not only rescues morphology but also both rod and cone system function in the Rb KO retina."}