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Id Subject Object Predicate Lexical cue
T11029 0-6 JJ denotes Normal
T11030 7-15 NN denotes Function
T11031 16-18 IN denotes of
T11032 19-22 DT denotes the
T11033 35-41 NN denotes Retina
T11034 23-25 NN denotes Rb
T11035 26-30 NN denotes E2f1
T11036 25-26 HYPH denotes /
T11037 31-34 NN denotes DKO
T11038 41-231 sentence denotes The discovery that E2f1 loss rescues even the morphology of Rb KO neurons is surprising because Rb is thought to regulate differentiation primarily through E2f-independent pathways [30–33].
T11039 42-45 DT denotes The
T11040 46-55 NN denotes discovery
T11041 116-118 VBZ denotes is
T11042 56-60 IN denotes that
T11043 71-78 VBZ denotes rescues
T11044 61-65 NN denotes E2f1
T11045 66-70 NN denotes loss
T11046 79-83 RB denotes even
T11047 88-98 NN denotes morphology
T11048 84-87 DT denotes the
T11049 99-101 IN denotes of
T11050 102-104 NN denotes Rb
T11051 105-107 NN denotes KO
T11052 108-115 NNS denotes neurons
T11053 119-129 JJ denotes surprising
T11054 130-137 IN denotes because
T11055 144-151 VBN denotes thought
T11056 138-140 NN denotes Rb
T11057 141-143 VBZ denotes is
T11058 152-154 TO denotes to
T11059 155-163 VB denotes regulate
T11060 164-179 NN denotes differentiation
T11061 180-189 RB denotes primarily
T11062 190-197 IN denotes through
T11063 198-201 NN denotes E2f
T11064 202-213 JJ denotes independent
T11065 201-202 HYPH denotes -
T11066 214-222 NNS denotes pathways
T11067 223-224 -LRB- denotes [
T11068 224-226 CD denotes 30
T11069 226-227 SYM denotes –
T11070 227-229 CD denotes 33
T11071 229-230 -RRB- denotes ]
T11072 230-231 . denotes .
T11073 231-311 sentence denotes However, normal morphology may not equate to completely normal differentiation.
T11074 232-239 RB denotes However
T11075 267-273 VB denotes equate
T11076 239-241 , denotes ,
T11077 241-247 JJ denotes normal
T11078 248-258 NN denotes morphology
T11079 259-262 MD denotes may
T11080 263-266 RB denotes not
T11081 274-276 IN denotes to
T11082 277-287 RB denotes completely
T11083 288-294 JJ denotes normal
T11084 295-310 NN denotes differentiation
T11085 310-311 . denotes .
T11086 311-444 sentence denotes Thus, we compared the electroretinograms (ERGs) of adult WT (α-Cre), E2f1−/−, α-Cre;RbloxP/loxP, and α-Cre;RbloxP/loxP;E2f1−/− mice.
T11087 312-316 RB denotes Thus
T11088 321-329 VBD denotes compared
T11089 316-318 , denotes ,
T11090 318-320 PRP denotes we
T11091 330-333 DT denotes the
T11092 334-352 NNS denotes electroretinograms
T11093 353-354 -LRB- denotes (
T11094 354-358 NNS denotes ERGs
T11095 358-359 -RRB- denotes )
T11096 360-362 IN denotes of
T11097 363-368 JJ denotes adult
T11098 439-443 NNS denotes mice
T11099 369-371 NN denotes WT
T11100 372-373 -LRB- denotes (
T11101 373-374 NN denotes α
T11102 375-378 NN denotes Cre
T11103 374-375 HYPH denotes -
T11104 378-379 -RRB- denotes )
T11105 379-381 , denotes ,
T11106 381-385 NN denotes E2f1
T11107 385-386 SYM denotes −
T11108 386-387 HYPH denotes /
T11109 387-388 SYM denotes −
T11110 388-390 , denotes ,
T11111 390-391 NN denotes α
T11112 392-395 NN denotes Cre
T11113 391-392 HYPH denotes -
T11114 395-396 : denotes ;
T11115 396-402 NN denotes RbloxP
T11116 403-407 NN denotes loxP
T11117 402-403 HYPH denotes /
T11118 407-409 , denotes ,
T11119 409-412 CC denotes and
T11120 413-414 NN denotes α
T11121 415-418 NN denotes Cre
T11122 414-415 HYPH denotes -
T11123 418-419 : denotes ;
T11124 419-425 NN denotes RbloxP
T11125 426-430 NN denotes loxP
T11126 425-426 HYPH denotes /
T11127 430-431 : denotes ;
T11128 431-435 NN denotes E2f1
T11129 435-436 SYM denotes −
T11130 436-437 HYPH denotes /
T11131 437-438 SYM denotes −
T11132 443-444 . denotes .
T11133 444-631 sentence denotes ERGs functionally assess visual signalling in the mammalian retina from photoreceptors to amacrine cells (but usually not gangion cells), and are dominated by rod and cone bipolar cells.
T11134 445-449 NNS denotes ERGs
T11135 463-469 VBP denotes assess
T11136 450-462 RB denotes functionally
T11137 470-476 JJ denotes visual
T11138 477-487 NN denotes signalling
T11139 488-490 IN denotes in
T11140 491-494 DT denotes the
T11141 505-511 NN denotes retina
T11142 495-504 JJ denotes mammalian
T11143 512-516 IN denotes from
T11144 517-531 NNS denotes photoreceptors
T11145 532-534 IN denotes to
T11146 535-543 JJ denotes amacrine
T11147 544-549 NNS denotes cells
T11148 550-551 -LRB- denotes (
T11149 551-554 CC denotes but
T11150 555-562 RB denotes usually
T11151 563-566 RB denotes not
T11152 575-580 NNS denotes cells
T11153 567-574 NN denotes gangion
T11154 580-581 -RRB- denotes )
T11155 581-583 , denotes ,
T11156 583-586 CC denotes and
T11157 587-590 VBP denotes are
T11158 591-600 VBN denotes dominated
T11159 601-603 IN denotes by
T11160 604-607 NN denotes rod
T11161 625-630 NNS denotes cells
T11162 608-611 CC denotes and
T11163 612-616 NN denotes cone
T11164 617-624 JJ denotes bipolar
T11165 630-631 . denotes .
T11166 631-843 sentence denotes Typically, an ERG signal begins with a negative deflection initiated by the photoreceptors (the a-wave), which is terminated by a large positive deflection due to the activation of ON bipolar cells (the b-wave).
T11167 632-641 RB denotes Typically
T11168 657-663 VBZ denotes begins
T11169 641-643 , denotes ,
T11170 643-645 DT denotes an
T11171 650-656 NN denotes signal
T11172 646-649 NN denotes ERG
T11173 664-668 IN denotes with
T11174 669-670 DT denotes a
T11175 680-690 NN denotes deflection
T11176 671-679 JJ denotes negative
T11177 691-700 VBN denotes initiated
T11178 701-703 IN denotes by
T11179 704-707 DT denotes the
T11180 708-722 NNS denotes photoreceptors
T11181 723-724 -LRB- denotes (
T11182 724-727 DT denotes the
T11183 730-734 NN denotes wave
T11184 728-729 NN denotes a
T11185 729-730 HYPH denotes -
T11186 734-735 -RRB- denotes )
T11187 735-737 , denotes ,
T11188 737-742 WDT denotes which
T11189 746-756 VBN denotes terminated
T11190 743-745 VBZ denotes is
T11191 757-759 IN denotes by
T11192 760-761 DT denotes a
T11193 777-787 NN denotes deflection
T11194 762-767 JJ denotes large
T11195 768-776 JJ denotes positive
T11196 788-791 IN denotes due
T11197 792-794 IN denotes to
T11198 795-798 DT denotes the
T11199 799-809 NN denotes activation
T11200 810-812 IN denotes of
T11201 813-815 NN denotes ON
T11202 824-829 NNS denotes cells
T11203 816-823 JJ denotes bipolar
T11204 830-831 -LRB- denotes (
T11205 831-834 DT denotes the
T11206 837-841 NN denotes wave
T11207 835-836 NN denotes b
T11208 836-837 HYPH denotes -
T11209 841-842 -RRB- denotes )
T11210 842-843 . denotes .
T11211 843-992 sentence denotes Responses to dim light in dark-adapted (scotopic) conditions specifically assess the rod system, and were defective in the Rb KO retina (Figure 2E).
T11212 844-853 NNS denotes Responses
T11213 918-924 VBP denotes assess
T11214 854-856 IN denotes to
T11215 857-860 JJ denotes dim
T11216 861-866 NN denotes light
T11217 867-869 IN denotes in
T11218 870-874 NN denotes dark
T11219 875-882 VBN denotes adapted
T11220 874-875 HYPH denotes -
T11221 894-904 NNS denotes conditions
T11222 883-884 -LRB- denotes (
T11223 884-892 JJ denotes scotopic
T11224 892-893 -RRB- denotes )
T11225 905-917 RB denotes specifically
T11226 925-928 DT denotes the
T11227 933-939 NN denotes system
T11228 929-932 NN denotes rod
T11229 939-941 , denotes ,
T11230 941-944 CC denotes and
T11231 945-949 VBD denotes were
T11232 950-959 JJ denotes defective
T11233 960-962 IN denotes in
T11234 963-966 DT denotes the
T11235 973-979 NN denotes retina
T11236 967-969 NN denotes Rb
T11237 970-972 NN denotes KO
T11238 980-981 -LRB- denotes (
T11239 988-990 NN denotes 2E
T11240 981-987 NN denotes Figure
T11241 990-991 -RRB- denotes )
T11242 991-992 . denotes .
T11243 992-1096 sentence denotes The substantial reduction of both a- and b-waves is consistent with rod and bipolar cell apoptosis [2].
T11244 993-996 DT denotes The
T11245 1009-1018 NN denotes reduction
T11246 997-1008 JJ denotes substantial
T11247 1042-1044 VBZ denotes is
T11248 1019-1021 IN denotes of
T11249 1022-1026 CC denotes both
T11250 1027-1028 NN denotes a
T11251 1036-1041 NNS denotes waves
T11252 1028-1029 HYPH denotes -
T11253 1030-1033 CC denotes and
T11254 1034-1035 NN denotes b
T11255 1035-1036 HYPH denotes -
T11256 1045-1055 JJ denotes consistent
T11257 1056-1060 IN denotes with
T11258 1061-1064 NN denotes rod
T11259 1082-1091 NN denotes apoptosis
T11260 1065-1068 CC denotes and
T11261 1069-1076 JJ denotes bipolar
T11262 1077-1081 NN denotes cell
T11263 1092-1093 -LRB- denotes [
T11264 1093-1094 CD denotes 2
T11265 1094-1095 -RRB- denotes ]
T11266 1095-1096 . denotes .
T11267 1096-1223 sentence denotes The sensitivity of the residual response appeared unchanged, suggesting it arose from the Cre-negative portions of the retina.
T11268 1097-1100 DT denotes The
T11269 1101-1112 NN denotes sensitivity
T11270 1138-1146 VBD denotes appeared
T11271 1113-1115 IN denotes of
T11272 1116-1119 DT denotes the
T11273 1129-1137 NN denotes response
T11274 1120-1128 JJ denotes residual
T11275 1147-1156 JJ denotes unchanged
T11276 1156-1158 , denotes ,
T11277 1158-1168 VBG denotes suggesting
T11278 1169-1171 PRP denotes it
T11279 1172-1177 VBD denotes arose
T11280 1178-1182 IN denotes from
T11281 1183-1186 DT denotes the
T11282 1200-1208 NNS denotes portions
T11283 1187-1190 NN denotes Cre
T11284 1191-1199 JJ denotes negative
T11285 1190-1191 HYPH denotes -
T11286 1209-1211 IN denotes of
T11287 1212-1215 DT denotes the
T11288 1216-1222 NN denotes retina
T11289 1222-1223 . denotes .
T11290 1223-1418 sentence denotes Responses were about the same in the WT and E2f1 KO retina, and, most importantly, also the Rb/E2f1 DKO response median lay at the lower end of the normal range for most intensities (Figure 2F).
T11291 1224-1233 NNS denotes Responses
T11292 1234-1238 VBD denotes were
T11293 1239-1244 RB denotes about
T11294 1249-1253 JJ denotes same
T11295 1245-1248 DT denotes the
T11296 1254-1256 IN denotes in
T11297 1257-1260 DT denotes the
T11298 1276-1282 NN denotes retina
T11299 1261-1263 NN denotes WT
T11300 1264-1267 CC denotes and
T11301 1268-1272 NN denotes E2f1
T11302 1273-1275 NN denotes KO
T11303 1282-1284 , denotes ,
T11304 1284-1287 CC denotes and
T11305 1287-1289 , denotes ,
T11306 1289-1293 RBS denotes most
T11307 1294-1305 RB denotes importantly
T11308 1344-1347 VBD denotes lay
T11309 1305-1307 , denotes ,
T11310 1307-1311 RB denotes also
T11311 1312-1315 DT denotes the
T11312 1328-1336 NN denotes response
T11313 1316-1318 NN denotes Rb
T11314 1319-1323 NN denotes E2f1
T11315 1318-1319 HYPH denotes /
T11316 1324-1327 NN denotes DKO
T11317 1337-1343 JJ denotes median
T11318 1348-1350 IN denotes at
T11319 1351-1354 DT denotes the
T11320 1361-1364 NN denotes end
T11321 1355-1360 JJ denotes lower
T11322 1365-1367 IN denotes of
T11323 1368-1371 DT denotes the
T11324 1379-1384 NN denotes range
T11325 1372-1378 JJ denotes normal
T11326 1385-1388 IN denotes for
T11327 1389-1393 JJS denotes most
T11328 1394-1405 NNS denotes intensities
T11329 1406-1407 -LRB- denotes (
T11330 1414-1416 NN denotes 2F
T11331 1407-1413 NN denotes Figure
T11332 1416-1417 -RRB- denotes )
T11333 1417-1418 . denotes .
T11334 1418-1500 sentence denotes Thus, E2f1 deletion almost completely rescued the rod system in the Rb KO retina.
T11335 1419-1423 RB denotes Thus
T11336 1457-1464 VBD denotes rescued
T11337 1423-1425 , denotes ,
T11338 1425-1429 NN denotes E2f1
T11339 1430-1438 NN denotes deletion
T11340 1439-1445 RB denotes almost
T11341 1446-1456 RB denotes completely
T11342 1465-1468 DT denotes the
T11343 1473-1479 NN denotes system
T11344 1469-1472 NN denotes rod
T11345 1480-1482 IN denotes in
T11346 1483-1486 DT denotes the
T11347 1493-1499 NN denotes retina
T11348 1487-1489 NN denotes Rb
T11349 1490-1492 NN denotes KO
T11350 1499-1500 . denotes .
T11351 1500-1603 sentence denotes Light-adapted (photopic) recordings to specifically assess the cone system yielded comparable results.
T11352 1501-1506 NN denotes Light
T11353 1507-1514 VBN denotes adapted
T11354 1506-1507 HYPH denotes -
T11355 1526-1536 NNS denotes recordings
T11356 1515-1516 -LRB- denotes (
T11357 1516-1524 JJ denotes photopic
T11358 1524-1525 -RRB- denotes )
T11359 1576-1583 VBD denotes yielded
T11360 1537-1539 TO denotes to
T11361 1553-1559 VB denotes assess
T11362 1540-1552 RB denotes specifically
T11363 1560-1563 DT denotes the
T11364 1569-1575 NN denotes system
T11365 1564-1568 NN denotes cone
T11366 1584-1594 JJ denotes comparable
T11367 1595-1602 NNS denotes results
T11368 1602-1603 . denotes .
T11369 1603-1840 sentence denotes Cones represent only 3% of photoreceptors and, unlike rods, develop without Rb, but they require rods for survival, and in the Rb KO retina, they have abnormal morphology and their synaptic targets, bipolar cells, are much depleted [2].
T11370 1604-1609 NNS denotes Cones
T11371 1610-1619 VBP denotes represent
T11372 1620-1624 RB denotes only
T11373 1625-1626 CD denotes 3
T11374 1626-1627 NN denotes %
T11375 1628-1630 IN denotes of
T11376 1631-1645 NNS denotes photoreceptors
T11377 1646-1649 CC denotes and
T11378 1649-1651 , denotes ,
T11379 1651-1657 JJ denotes unlike
T11380 1664-1671 VBP denotes develop
T11381 1658-1662 NNS denotes rods
T11382 1662-1664 , denotes ,
T11383 1672-1679 IN denotes without
T11384 1680-1682 NN denotes Rb
T11385 1682-1684 , denotes ,
T11386 1684-1687 CC denotes but
T11387 1688-1692 PRP denotes they
T11388 1693-1700 VBP denotes require
T11389 1701-1705 NNS denotes rods
T11390 1706-1709 IN denotes for
T11391 1710-1718 NN denotes survival
T11392 1718-1720 , denotes ,
T11393 1720-1723 CC denotes and
T11394 1724-1726 IN denotes in
T11395 1750-1754 VBP denotes have
T11396 1727-1730 DT denotes the
T11397 1737-1743 NN denotes retina
T11398 1731-1733 NN denotes Rb
T11399 1734-1736 NN denotes KO
T11400 1743-1745 , denotes ,
T11401 1745-1749 PRP denotes they
T11402 1755-1763 JJ denotes abnormal
T11403 1764-1774 NN denotes morphology
T11404 1775-1778 CC denotes and
T11405 1779-1784 PRP$ denotes their
T11406 1794-1801 NNS denotes targets
T11407 1785-1793 JJ denotes synaptic
T11408 1818-1821 VBP denotes are
T11409 1801-1803 , denotes ,
T11410 1803-1810 JJ denotes bipolar
T11411 1811-1816 NNS denotes cells
T11412 1816-1818 , denotes ,
T11413 1822-1826 RB denotes much
T11414 1827-1835 JJ denotes depleted
T11415 1836-1837 -LRB- denotes [
T11416 1837-1838 CD denotes 2
T11417 1838-1839 -RRB- denotes ]
T11418 1839-1840 . denotes .
T11419 1840-2007 sentence denotes The photopic response, a product of cone and mainly bipolar activity, was much reduced by Rb loss, but was rescued considerably in the Rb/E2f1 DKO retina (Figure S5).
T11420 1841-1844 DT denotes The
T11421 1854-1862 NN denotes response
T11422 1845-1853 JJ denotes photopic
T11423 1920-1927 VBN denotes reduced
T11424 1862-1864 , denotes ,
T11425 1864-1865 DT denotes a
T11426 1866-1873 NN denotes product
T11427 1874-1876 IN denotes of
T11428 1877-1881 NN denotes cone
T11429 1901-1909 NN denotes activity
T11430 1882-1885 CC denotes and
T11431 1886-1892 RB denotes mainly
T11432 1893-1900 JJ denotes bipolar
T11433 1909-1911 , denotes ,
T11434 1911-1914 VBD denotes was
T11435 1915-1919 RB denotes much
T11436 1928-1930 IN denotes by
T11437 1931-1933 NN denotes Rb
T11438 1934-1938 NN denotes loss
T11439 1938-1940 , denotes ,
T11440 1940-1943 CC denotes but
T11441 1944-1947 VBD denotes was
T11442 1948-1955 VBN denotes rescued
T11443 1956-1968 RB denotes considerably
T11444 1969-1971 IN denotes in
T11445 1972-1975 DT denotes the
T11446 1988-1994 NN denotes retina
T11447 1976-1978 NN denotes Rb
T11448 1979-1983 NN denotes E2f1
T11449 1978-1979 HYPH denotes /
T11450 1984-1987 NN denotes DKO
T11451 1995-1996 -LRB- denotes (
T11452 2003-2005 NN denotes S5
T11453 1996-2002 NN denotes Figure
T11454 2005-2006 -RRB- denotes )
T11455 2006-2007 . denotes .
T11456 2007-2078 sentence denotes Again, the median amplitude lay at the lower end of the E2f1 KO range.
T11457 2008-2013 RB denotes Again
T11458 2036-2039 VBD denotes lay
T11459 2013-2015 , denotes ,
T11460 2015-2018 DT denotes the
T11461 2026-2035 NN denotes amplitude
T11462 2019-2025 JJ denotes median
T11463 2040-2042 IN denotes at
T11464 2043-2046 DT denotes the
T11465 2053-2056 NN denotes end
T11466 2047-2052 JJ denotes lower
T11467 2057-2059 IN denotes of
T11468 2060-2063 DT denotes the
T11469 2072-2077 NN denotes range
T11470 2064-2068 NN denotes E2f1
T11471 2069-2071 NN denotes KO
T11472 2077-2078 . denotes .
T11473 2078-2411 sentence denotes The photopic response in E2f1 KO mice was slightly reduced relative to WT (Figure S5B), possibly because E2f1 is required for maximal expansion of embryonic RPCs, and the E2f1 KO retina has, as noted earlier, slightly fewer cells than the WT retina, although cell type proportions are unaffected (D. C. and R. B., unpublished data).
T11474 2079-2082 DT denotes The
T11475 2092-2100 NN denotes response
T11476 2083-2091 JJ denotes photopic
T11477 2130-2137 VBN denotes reduced
T11478 2101-2103 IN denotes in
T11479 2104-2108 NN denotes E2f1
T11480 2109-2111 NN denotes KO
T11481 2112-2116 NNS denotes mice
T11482 2117-2120 VBD denotes was
T11483 2121-2129 RB denotes slightly
T11484 2138-2146 JJ denotes relative
T11485 2147-2149 IN denotes to
T11486 2150-2152 NN denotes WT
T11487 2153-2154 -LRB- denotes (
T11488 2161-2164 NN denotes S5B
T11489 2154-2160 NN denotes Figure
T11490 2164-2165 -RRB- denotes )
T11491 2165-2167 , denotes ,
T11492 2167-2175 RB denotes possibly
T11493 2192-2200 VBN denotes required
T11494 2176-2183 IN denotes because
T11495 2184-2188 NN denotes E2f1
T11496 2189-2191 VBZ denotes is
T11497 2201-2204 IN denotes for
T11498 2205-2212 JJ denotes maximal
T11499 2213-2222 NN denotes expansion
T11500 2223-2225 IN denotes of
T11501 2226-2235 JJ denotes embryonic
T11502 2236-2240 NNS denotes RPCs
T11503 2240-2242 , denotes ,
T11504 2242-2245 CC denotes and
T11505 2246-2249 DT denotes the
T11506 2258-2264 NN denotes retina
T11507 2250-2254 NN denotes E2f1
T11508 2255-2257 NN denotes KO
T11509 2265-2268 VBZ denotes has
T11510 2268-2270 , denotes ,
T11511 2270-2272 IN denotes as
T11512 2273-2278 VBN denotes noted
T11513 2279-2286 RBR denotes earlier
T11514 2286-2288 , denotes ,
T11515 2288-2296 RB denotes slightly
T11516 2297-2302 JJR denotes fewer
T11517 2303-2308 NNS denotes cells
T11518 2309-2313 IN denotes than
T11519 2314-2317 DT denotes the
T11520 2321-2327 NN denotes retina
T11521 2318-2320 NN denotes WT
T11522 2327-2329 , denotes ,
T11523 2329-2337 IN denotes although
T11524 2360-2363 VBP denotes are
T11525 2338-2342 NN denotes cell
T11526 2343-2347 NN denotes type
T11527 2348-2359 NNS denotes proportions
T11528 2364-2374 JJ denotes unaffected
T11529 2375-2376 -LRB- denotes (
T11530 2376-2378 NNP denotes D.
T11531 2379-2381 NNP denotes C.
T11532 2382-2385 CC denotes and
T11533 2386-2388 NNP denotes R.
T11534 2389-2391 NNP denotes B.
T11535 2391-2393 , denotes ,
T11536 2393-2404 JJ denotes unpublished
T11537 2405-2409 NNS denotes data
T11538 2409-2410 -RRB- denotes )
T11539 2410-2411 . denotes .
T11540 2411-2650 sentence denotes Thus, marginally subnormal photopic responses in the Rb/E2f1 DKO retina can be attributed to both a reduction of cone numbers in E2f1 KO mice alone, and a “genuine” slight reduction in cone function attributable to Rb loss relative to WT.
T11541 2412-2416 RB denotes Thus
T11542 2491-2501 VBN denotes attributed
T11543 2416-2418 , denotes ,
T11544 2418-2428 RB denotes marginally
T11545 2429-2438 JJ denotes subnormal
T11546 2448-2457 NNS denotes responses
T11547 2439-2447 JJ denotes photopic
T11548 2458-2460 IN denotes in
T11549 2461-2464 DT denotes the
T11550 2477-2483 NN denotes retina
T11551 2465-2467 NN denotes Rb
T11552 2468-2472 NN denotes E2f1
T11553 2467-2468 HYPH denotes /
T11554 2473-2476 NN denotes DKO
T11555 2484-2487 MD denotes can
T11556 2488-2490 VB denotes be
T11557 2502-2504 IN denotes to
T11558 2505-2509 CC denotes both
T11559 2512-2521 NN denotes reduction
T11560 2510-2511 DT denotes a
T11561 2522-2524 IN denotes of
T11562 2525-2529 NN denotes cone
T11563 2530-2537 NNS denotes numbers
T11564 2538-2540 IN denotes in
T11565 2541-2545 NN denotes E2f1
T11566 2546-2548 NN denotes KO
T11567 2549-2553 NNS denotes mice
T11568 2554-2559 RB denotes alone
T11569 2559-2561 , denotes ,
T11570 2561-2564 CC denotes and
T11571 2565-2566 DT denotes a
T11572 2584-2593 NN denotes reduction
T11573 2567-2568 `` denotes “
T11574 2568-2575 JJ denotes genuine
T11575 2575-2576 '' denotes ”
T11576 2577-2583 JJ denotes slight
T11577 2594-2596 IN denotes in
T11578 2597-2601 NN denotes cone
T11579 2602-2610 NN denotes function
T11580 2611-2623 JJ denotes attributable
T11581 2624-2626 IN denotes to
T11582 2627-2629 NN denotes Rb
T11583 2630-2634 NN denotes loss
T11584 2635-2643 JJ denotes relative
T11585 2644-2646 IN denotes to
T11586 2647-2649 NN denotes WT
T11587 2649-2650 . denotes .
T11588 2650-2760 sentence denotes This slight effect may relate to a true differentiation defect in a subset of amacrine cells discussed below.
T11589 2651-2655 DT denotes This
T11590 2663-2669 NN denotes effect
T11591 2656-2662 JJ denotes slight
T11592 2674-2680 VB denotes relate
T11593 2670-2673 MD denotes may
T11594 2681-2683 IN denotes to
T11595 2684-2685 DT denotes a
T11596 2707-2713 NN denotes defect
T11597 2686-2690 JJ denotes true
T11598 2691-2706 NN denotes differentiation
T11599 2714-2716 IN denotes in
T11600 2717-2718 DT denotes a
T11601 2719-2725 NN denotes subset
T11602 2726-2728 IN denotes of
T11603 2729-2737 JJ denotes amacrine
T11604 2738-2743 NNS denotes cells
T11605 2744-2753 VBN denotes discussed
T11606 2754-2759 RB denotes below
T11607 2759-2760 . denotes .
T11608 2760-2867 sentence denotes This discussion should not obscure the major outcome that E2f1 deletion recovers most of the ERG response.
T11609 2761-2765 DT denotes This
T11610 2766-2776 NN denotes discussion
T11611 2788-2795 VB denotes obscure
T11612 2777-2783 MD denotes should
T11613 2784-2787 RB denotes not
T11614 2796-2799 DT denotes the
T11615 2806-2813 NN denotes outcome
T11616 2800-2805 JJ denotes major
T11617 2814-2818 IN denotes that
T11618 2833-2841 VBZ denotes recovers
T11619 2819-2823 NN denotes E2f1
T11620 2824-2832 NN denotes deletion
T11621 2842-2846 JJS denotes most
T11622 2847-2849 IN denotes of
T11623 2850-2853 DT denotes the
T11624 2858-2866 NN denotes response
T11625 2854-2857 NN denotes ERG
T11626 2866-2867 . denotes .
T11627 2867-2979 sentence denotes Thus, E2f1 deletion not only rescues morphology but also both rod and cone system function in the Rb KO retina.
T11628 2868-2872 RB denotes Thus
T11629 2879-2887 NN denotes deletion
T11630 2872-2874 , denotes ,
T11631 2874-2878 NN denotes E2f1
T11632 2888-2891 RB denotes not
T11633 2892-2896 RB denotes only
T11634 2897-2904 VBZ denotes rescues
T11635 2905-2915 NN denotes morphology
T11636 2916-2919 CC denotes but
T11637 2920-2924 RB denotes also
T11638 2925-2929 CC denotes both
T11639 2930-2933 NN denotes rod
T11640 2950-2958 NN denotes function
T11641 2934-2937 CC denotes and
T11642 2938-2942 NN denotes cone
T11643 2943-2949 NN denotes system
T11644 2959-2961 IN denotes in
T11645 2962-2965 DT denotes the
T11646 2972-2978 NN denotes retina
T11647 2966-2968 NN denotes Rb
T11648 2969-2971 NN denotes KO
T11649 2978-2979 . denotes .
R2937 T11029 T11030 amod Normal,Function
R2938 T11031 T11030 prep of,Function
R2939 T11032 T11033 det the,Retina
R2940 T11033 T11031 pobj Retina,of
R2941 T11034 T11035 compound Rb,E2f1
R2942 T11035 T11037 compound E2f1,DKO
R2943 T11036 T11035 punct /,E2f1
R2944 T11037 T11033 compound DKO,Retina
R2945 T11039 T11040 det The,discovery
R2946 T11040 T11041 nsubj discovery,is
R2947 T11042 T11043 mark that,rescues
R2948 T11043 T11040 acl rescues,discovery
R2949 T11044 T11045 compound E2f1,loss
R2950 T11045 T11043 nsubj loss,rescues
R2951 T11046 T11047 advmod even,morphology
R2952 T11047 T11043 dobj morphology,rescues
R2953 T11048 T11047 det the,morphology
R2954 T11049 T11047 prep of,morphology
R2955 T11050 T11051 compound Rb,KO
R2956 T11051 T11052 compound KO,neurons
R2957 T11052 T11049 pobj neurons,of
R2958 T11053 T11041 acomp surprising,is
R2959 T11054 T11055 mark because,thought
R2960 T11055 T11041 advcl thought,is
R2961 T11056 T11055 nsubjpass Rb,thought
R2962 T11057 T11055 auxpass is,thought
R2963 T11058 T11059 aux to,regulate
R2964 T11059 T11055 xcomp regulate,thought
R2965 T11060 T11059 dobj differentiation,regulate
R2966 T11061 T11062 advmod primarily,through
R2967 T11062 T11059 prep through,regulate
R2968 T11063 T11064 npadvmod E2f,independent
R2969 T11064 T11066 amod independent,pathways
R2970 T11065 T11064 punct -,independent
R2971 T11066 T11062 pobj pathways,through
R2972 T11067 T11068 punct [,30
R2973 T11068 T11041 parataxis 30,is
R2974 T11069 T11070 punct –,33
R2975 T11070 T11068 prep 33,30
R2976 T11071 T11068 punct ],30
R2977 T11072 T11041 punct .,is
R2978 T11074 T11075 advmod However,equate
R2979 T11076 T11075 punct ", ",equate
R2980 T11077 T11078 amod normal,morphology
R2981 T11078 T11075 nsubj morphology,equate
R2982 T11079 T11075 aux may,equate
R2983 T11080 T11075 neg not,equate
R2984 T11081 T11075 prep to,equate
R2985 T11082 T11083 advmod completely,normal
R2986 T11083 T11084 amod normal,differentiation
R2987 T11084 T11081 pobj differentiation,to
R2988 T11085 T11075 punct .,equate
R2989 T11087 T11088 advmod Thus,compared
R2990 T11089 T11088 punct ", ",compared
R2991 T11090 T11088 nsubj we,compared
R2992 T11091 T11092 det the,electroretinograms
R2993 T11092 T11088 dobj electroretinograms,compared
R2994 T11093 T11092 punct (,electroretinograms
R2995 T11094 T11092 appos ERGs,electroretinograms
R2996 T11095 T11092 punct ),electroretinograms
R2997 T11096 T11092 prep of,electroretinograms
R2998 T11097 T11098 amod adult,mice
R2999 T11098 T11096 pobj mice,of
R3000 T11099 T11098 nmod WT,mice
R3001 T11100 T11099 punct (,WT
R3002 T11101 T11102 compound α,Cre
R3003 T11102 T11099 appos Cre,WT
R3004 T11103 T11102 punct -,Cre
R3005 T11104 T11099 punct ),WT
R3006 T11105 T11099 punct ", ",WT
R3007 T11106 T11099 conj E2f1,WT
R3008 T11107 T11106 punct −,E2f1
R3009 T11108 T11106 punct /,E2f1
R3010 T11109 T11106 punct −,E2f1
R3011 T11110 T11106 punct ", ",E2f1
R3012 T11111 T11112 compound α,Cre
R3013 T11112 T11106 conj Cre,E2f1
R3014 T11113 T11112 punct -,Cre
R3015 T11114 T11112 punct ;,Cre
R3016 T11115 T11116 compound RbloxP,loxP
R3017 T11116 T11112 appos loxP,Cre
R3018 T11117 T11116 punct /,loxP
R3019 T11118 T11112 punct ", ",Cre
R3020 T11119 T11112 cc and,Cre
R3021 T11120 T11121 compound α,Cre
R3022 T11121 T11112 conj Cre,Cre
R3023 T11122 T11121 punct -,Cre
R3024 T11123 T11121 punct ;,Cre
R3025 T11124 T11125 compound RbloxP,loxP
R3026 T11125 T11121 appos loxP,Cre
R3027 T11126 T11125 punct /,loxP
R3028 T11127 T11121 punct ;,Cre
R3029 T11128 T11121 appos E2f1,Cre
R3030 T11129 T11128 punct −,E2f1
R3031 T11130 T11128 punct /,E2f1
R3032 T11131 T11128 punct −,E2f1
R3033 T11132 T11088 punct .,compared
R3034 T11134 T11135 nsubj ERGs,assess
R3035 T11136 T11135 advmod functionally,assess
R3036 T11137 T11138 amod visual,signalling
R3037 T11138 T11135 dobj signalling,assess
R3038 T11139 T11138 prep in,signalling
R3039 T11140 T11141 det the,retina
R3040 T11141 T11139 pobj retina,in
R3041 T11142 T11141 amod mammalian,retina
R3042 T11143 T11138 prep from,signalling
R3043 T11144 T11143 pobj photoreceptors,from
R3044 T11145 T11143 prep to,from
R3045 T11146 T11147 amod amacrine,cells
R3046 T11147 T11145 pobj cells,to
R3047 T11148 T11147 punct (,cells
R3048 T11149 T11147 cc but,cells
R3049 T11150 T11151 advmod usually,not
R3050 T11151 T11152 neg not,cells
R3051 T11152 T11147 conj cells,cells
R3052 T11153 T11152 compound gangion,cells
R3053 T11154 T11135 punct ),assess
R3054 T11155 T11135 punct ", ",assess
R3055 T11156 T11135 cc and,assess
R3056 T11157 T11158 auxpass are,dominated
R3057 T11158 T11135 conj dominated,assess
R3058 T11159 T11158 agent by,dominated
R3059 T11160 T11161 nmod rod,cells
R3060 T11161 T11159 pobj cells,by
R3061 T11162 T11160 cc and,rod
R3062 T11163 T11160 conj cone,rod
R3063 T11164 T11161 amod bipolar,cells
R3064 T11165 T11135 punct .,assess
R3065 T11167 T11168 advmod Typically,begins
R3066 T11169 T11168 punct ", ",begins
R3067 T11170 T11171 det an,signal
R3068 T11171 T11168 nsubj signal,begins
R3069 T11172 T11171 compound ERG,signal
R3070 T11173 T11168 prep with,begins
R3071 T11174 T11175 det a,deflection
R3072 T11175 T11173 pobj deflection,with
R3073 T11176 T11175 amod negative,deflection
R3074 T11177 T11175 acl initiated,deflection
R3075 T11178 T11177 agent by,initiated
R3076 T11179 T11180 det the,photoreceptors
R3077 T11180 T11178 pobj photoreceptors,by
R3078 T11181 T11175 punct (,deflection
R3079 T11182 T11183 det the,wave
R3080 T11183 T11175 appos wave,deflection
R3081 T11184 T11183 compound a,wave
R3082 T11185 T11183 punct -,wave
R3083 T11186 T11175 punct ),deflection
R3084 T11187 T11175 punct ", ",deflection
R3085 T11188 T11189 dep which,terminated
R3086 T11189 T11175 relcl terminated,deflection
R3087 T11190 T11189 auxpass is,terminated
R3088 T11191 T11189 agent by,terminated
R3089 T11192 T11193 det a,deflection
R3090 T11193 T11191 pobj deflection,by
R3091 T11194 T11193 amod large,deflection
R3092 T11195 T11193 amod positive,deflection
R3093 T11196 T11189 prep due,terminated
R3094 T11197 T11196 pcomp to,due
R3095 T11198 T11199 det the,activation
R3096 T11199 T11196 pobj activation,due
R3097 T11200 T11199 prep of,activation
R3098 T11201 T11202 nmod ON,cells
R3099 T11202 T11200 pobj cells,of
R3100 T11203 T11202 amod bipolar,cells
R3101 T11204 T11189 punct (,terminated
R3102 T11205 T11206 det the,wave
R3103 T11206 T11189 dobj wave,terminated
R3104 T11207 T11206 compound b,wave
R3105 T11208 T11206 punct -,wave
R3106 T11209 T11168 punct ),begins
R3107 T11210 T11168 punct .,begins
R3108 T11212 T11213 nsubj Responses,assess
R3109 T11214 T11212 prep to,Responses
R3110 T11215 T11216 amod dim,light
R3111 T11216 T11214 pobj light,to
R3112 T11217 T11212 prep in,Responses
R3113 T11218 T11219 npadvmod dark,adapted
R3114 T11219 T11221 amod adapted,conditions
R3115 T11220 T11219 punct -,adapted
R3116 T11221 T11217 pobj conditions,in
R3117 T11222 T11223 punct (,scotopic
R3118 T11223 T11219 parataxis scotopic,adapted
R3119 T11224 T11223 punct ),scotopic
R3120 T11225 T11213 advmod specifically,assess
R3121 T11226 T11227 det the,system
R3122 T11227 T11213 dobj system,assess
R3123 T11228 T11227 compound rod,system
R3124 T11229 T11213 punct ", ",assess
R3125 T11230 T11213 cc and,assess
R3126 T11231 T11213 conj were,assess
R3127 T11232 T11231 acomp defective,were
R3128 T11233 T11231 prep in,were
R3129 T11234 T11235 det the,retina
R3130 T11235 T11233 pobj retina,in
R3131 T11236 T11237 compound Rb,KO
R3132 T11237 T11235 compound KO,retina
R3133 T11238 T11239 punct (,2E
R3134 T11239 T11231 parataxis 2E,were
R3135 T11240 T11239 compound Figure,2E
R3136 T11241 T11239 punct ),2E
R3137 T11242 T11213 punct .,assess
R3138 T11244 T11245 det The,reduction
R3139 T11245 T11247 nsubj reduction,is
R3140 T11246 T11245 amod substantial,reduction
R3141 T11248 T11245 prep of,reduction
R3142 T11249 T11250 preconj both,a
R3143 T11250 T11251 nmod a,waves
R3144 T11251 T11248 pobj waves,of
R3145 T11252 T11250 punct -,a
R3146 T11253 T11250 cc and,a
R3147 T11254 T11250 conj b,a
R3148 T11255 T11251 punct -,waves
R3149 T11256 T11247 acomp consistent,is
R3150 T11257 T11256 prep with,consistent
R3151 T11258 T11259 nmod rod,apoptosis
R3152 T11259 T11257 pobj apoptosis,with
R3153 T11260 T11258 cc and,rod
R3154 T11261 T11262 amod bipolar,cell
R3155 T11262 T11258 conj cell,rod
R3156 T11263 T11264 punct [,2
R3157 T11264 T11247 parataxis 2,is
R3158 T11265 T11264 punct ],2
R3159 T11266 T11247 punct .,is
R3160 T11268 T11269 det The,sensitivity
R3161 T11269 T11270 nsubj sensitivity,appeared
R3162 T11271 T11269 prep of,sensitivity
R3163 T11272 T11273 det the,response
R3164 T11273 T11271 pobj response,of
R3165 T11274 T11273 amod residual,response
R3166 T11275 T11270 oprd unchanged,appeared
R3167 T11276 T11270 punct ", ",appeared
R3168 T11277 T11270 advcl suggesting,appeared
R3169 T11278 T11279 nsubj it,arose
R3170 T11279 T11277 advcl arose,suggesting
R3171 T11280 T11279 prep from,arose
R3172 T11281 T11282 det the,portions
R3173 T11282 T11280 pobj portions,from
R3174 T11283 T11284 npadvmod Cre,negative
R3175 T11284 T11282 amod negative,portions
R3176 T11285 T11284 punct -,negative
R3177 T11286 T11282 prep of,portions
R3178 T11287 T11288 det the,retina
R3179 T11288 T11286 pobj retina,of
R3180 T11289 T11270 punct .,appeared
R3181 T11291 T11292 nsubj Responses,were
R3182 T11293 T11294 advmod about,same
R3183 T11294 T11292 attr same,were
R3184 T11295 T11294 det the,same
R3185 T11296 T11292 prep in,were
R3186 T11297 T11298 det the,retina
R3187 T11298 T11296 pobj retina,in
R3188 T11299 T11298 nmod WT,retina
R3189 T11300 T11299 cc and,WT
R3190 T11301 T11302 compound E2f1,KO
R3191 T11302 T11299 conj KO,WT
R3192 T11303 T11292 punct ", ",were
R3193 T11304 T11292 cc and,were
R3194 T11305 T11292 punct ", ",were
R3195 T11306 T11307 advmod most,importantly
R3196 T11307 T11308 advmod importantly,lay
R3197 T11308 T11292 conj lay,were
R3198 T11309 T11308 punct ", ",lay
R3199 T11310 T11308 advmod also,lay
R3200 T11311 T11312 det the,response
R3201 T11312 T11308 nsubj response,lay
R3202 T11313 T11314 compound Rb,E2f1
R3203 T11314 T11316 compound E2f1,DKO
R3204 T11315 T11314 punct /,E2f1
R3205 T11316 T11312 compound DKO,response
R3206 T11317 T11312 amod median,response
R3207 T11318 T11308 prep at,lay
R3208 T11319 T11320 det the,end
R3209 T11320 T11318 pobj end,at
R3210 T11321 T11320 amod lower,end
R3211 T11322 T11320 prep of,end
R3212 T11323 T11324 det the,range
R3213 T11324 T11322 pobj range,of
R3214 T11325 T11324 amod normal,range
R3215 T11326 T11308 prep for,lay
R3216 T11327 T11328 amod most,intensities
R3217 T11328 T11326 pobj intensities,for
R3218 T11329 T11330 punct (,2F
R3219 T11330 T11308 parataxis 2F,lay
R3220 T11331 T11330 compound Figure,2F
R3221 T11332 T11330 punct ),2F
R3222 T11333 T11308 punct .,lay
R3223 T11335 T11336 advmod Thus,rescued
R3224 T11337 T11336 punct ", ",rescued
R3225 T11338 T11339 compound E2f1,deletion
R3226 T11339 T11336 nsubj deletion,rescued
R3227 T11340 T11341 advmod almost,completely
R3228 T11341 T11336 advmod completely,rescued
R3229 T11342 T11343 det the,system
R3230 T11343 T11336 dobj system,rescued
R3231 T11344 T11343 compound rod,system
R3232 T11345 T11336 prep in,rescued
R3233 T11346 T11347 det the,retina
R3234 T11347 T11345 pobj retina,in
R3235 T11348 T11349 compound Rb,KO
R3236 T11349 T11347 compound KO,retina
R3237 T11350 T11336 punct .,rescued
R3238 T11352 T11353 npadvmod Light,adapted
R3239 T11353 T11355 amod adapted,recordings
R3240 T11354 T11353 punct -,adapted
R3241 T11355 T11359 nsubj recordings,yielded
R3242 T11356 T11357 punct (,photopic
R3243 T11357 T11353 parataxis photopic,adapted
R3244 T11358 T11357 punct ),photopic
R3245 T11360 T11361 aux to,assess
R3246 T11361 T11355 advcl assess,recordings
R3247 T11362 T11361 advmod specifically,assess
R3248 T11363 T11364 det the,system
R3249 T11364 T11361 dobj system,assess
R3250 T11365 T11364 compound cone,system
R3251 T11366 T11367 amod comparable,results
R3252 T11367 T11359 dobj results,yielded
R3253 T11368 T11359 punct .,yielded
R3254 T11370 T11371 nsubj Cones,represent
R3255 T11372 T11373 advmod only,3
R3256 T11373 T11374 nummod 3,%
R3257 T11374 T11371 dobj %,represent
R3258 T11375 T11374 prep of,%
R3259 T11376 T11375 pobj photoreceptors,of
R3260 T11377 T11371 cc and,represent
R3261 T11378 T11371 punct ", ",represent
R3262 T11379 T11380 prep unlike,develop
R3263 T11380 T11371 conj develop,represent
R3264 T11381 T11379 pobj rods,unlike
R3265 T11382 T11380 punct ", ",develop
R3266 T11383 T11380 prep without,develop
R3267 T11384 T11383 pobj Rb,without
R3268 T11385 T11371 punct ", ",represent
R3269 T11386 T11371 cc but,represent
R3270 T11387 T11388 nsubj they,require
R3271 T11388 T11371 conj require,represent
R3272 T11389 T11388 dobj rods,require
R3273 T11390 T11388 prep for,require
R3274 T11391 T11390 pobj survival,for
R3275 T11392 T11388 punct ", ",require
R3276 T11393 T11388 cc and,require
R3277 T11394 T11395 prep in,have
R3278 T11395 T11388 conj have,require
R3279 T11396 T11397 det the,retina
R3280 T11397 T11394 pobj retina,in
R3281 T11398 T11399 compound Rb,KO
R3282 T11399 T11397 compound KO,retina
R3283 T11400 T11395 punct ", ",have
R3284 T11401 T11395 nsubj they,have
R3285 T11402 T11403 amod abnormal,morphology
R3286 T11403 T11395 dobj morphology,have
R3287 T11404 T11395 cc and,have
R3288 T11405 T11406 poss their,targets
R3289 T11406 T11408 nsubj targets,are
R3290 T11407 T11406 amod synaptic,targets
R3291 T11408 T11395 conj are,have
R3292 T11409 T11406 punct ", ",targets
R3293 T11410 T11411 amod bipolar,cells
R3294 T11411 T11406 appos cells,targets
R3295 T11412 T11408 punct ", ",are
R3296 T11413 T11414 advmod much,depleted
R3297 T11414 T11408 acomp depleted,are
R3298 T11415 T11416 punct [,2
R3299 T11416 T11408 parataxis 2,are
R3300 T11417 T11416 punct ],2
R3301 T11418 T11408 punct .,are
R3302 T11420 T11421 det The,response
R3303 T11421 T11423 nsubjpass response,reduced
R3304 T11422 T11421 amod photopic,response
R3305 T11424 T11421 punct ", ",response
R3306 T11425 T11426 det a,product
R3307 T11426 T11421 appos product,response
R3308 T11427 T11426 prep of,product
R3309 T11428 T11429 nmod cone,activity
R3310 T11429 T11427 pobj activity,of
R3311 T11430 T11428 cc and,cone
R3312 T11431 T11432 advmod mainly,bipolar
R3313 T11432 T11428 conj bipolar,cone
R3314 T11433 T11423 punct ", ",reduced
R3315 T11434 T11423 auxpass was,reduced
R3316 T11435 T11423 advmod much,reduced
R3317 T11436 T11423 agent by,reduced
R3318 T11437 T11438 compound Rb,loss
R3319 T11438 T11436 pobj loss,by
R3320 T11439 T11423 punct ", ",reduced
R3321 T11440 T11423 cc but,reduced
R3322 T11441 T11442 auxpass was,rescued
R3323 T11442 T11423 conj rescued,reduced
R3324 T11443 T11442 advmod considerably,rescued
R3325 T11444 T11442 prep in,rescued
R3326 T11445 T11446 det the,retina
R3327 T11446 T11444 pobj retina,in
R3328 T11447 T11448 compound Rb,E2f1
R3329 T11448 T11450 compound E2f1,DKO
R3330 T11449 T11448 punct /,E2f1
R3331 T11450 T11446 compound DKO,retina
R3332 T11451 T11452 punct (,S5
R3333 T11452 T11442 parataxis S5,rescued
R3334 T11453 T11452 compound Figure,S5
R3335 T11454 T11452 punct ),S5
R3336 T11455 T11423 punct .,reduced
R3337 T11457 T11458 advmod Again,lay
R3338 T11459 T11458 punct ", ",lay
R3339 T11460 T11461 det the,amplitude
R3340 T11461 T11458 nsubj amplitude,lay
R3341 T11462 T11461 amod median,amplitude
R3342 T11463 T11458 prep at,lay
R3343 T11464 T11465 det the,end
R3344 T11465 T11463 pobj end,at
R3345 T11466 T11465 amod lower,end
R3346 T11467 T11465 prep of,end
R3347 T11468 T11469 det the,range
R3348 T11469 T11467 pobj range,of
R3349 T11470 T11471 compound E2f1,KO
R3350 T11471 T11469 compound KO,range
R3351 T11472 T11458 punct .,lay
R3352 T11474 T11475 det The,response
R3353 T11475 T11477 nsubjpass response,reduced
R3354 T11476 T11475 amod photopic,response
R3355 T11478 T11475 prep in,response
R3356 T11479 T11480 compound E2f1,KO
R3357 T11480 T11481 compound KO,mice
R3358 T11481 T11478 pobj mice,in
R3359 T11482 T11477 auxpass was,reduced
R3360 T11483 T11477 advmod slightly,reduced
R3361 T11484 T11477 advcl relative,reduced
R3362 T11485 T11484 prep to,relative
R3363 T11486 T11485 pobj WT,to
R3364 T11487 T11488 punct (,S5B
R3365 T11488 T11477 parataxis S5B,reduced
R3366 T11489 T11488 compound Figure,S5B
R3367 T11490 T11488 punct ),S5B
R3368 T11491 T11477 punct ", ",reduced
R3369 T11492 T11493 advmod possibly,required
R3370 T11493 T11477 advcl required,reduced
R3371 T11494 T11493 mark because,required
R3372 T11495 T11493 nsubjpass E2f1,required
R3373 T11496 T11493 auxpass is,required
R3374 T11497 T11493 prep for,required
R3375 T11498 T11499 amod maximal,expansion
R3376 T11499 T11497 pobj expansion,for
R3377 T11500 T11499 prep of,expansion
R3378 T11501 T11502 amod embryonic,RPCs
R3379 T11502 T11500 pobj RPCs,of
R3380 T11503 T11477 punct ", ",reduced
R3381 T11504 T11477 cc and,reduced
R3382 T11505 T11506 det the,retina
R3383 T11506 T11509 nsubj retina,has
R3384 T11507 T11508 compound E2f1,KO
R3385 T11508 T11506 compound KO,retina
R3386 T11509 T11477 conj has,reduced
R3387 T11510 T11509 punct ", ",has
R3388 T11511 T11512 mark as,noted
R3389 T11512 T11509 advcl noted,has
R3390 T11513 T11512 advmod earlier,noted
R3391 T11514 T11509 punct ", ",has
R3392 T11515 T11516 advmod slightly,fewer
R3393 T11516 T11517 amod fewer,cells
R3394 T11517 T11509 dobj cells,has
R3395 T11518 T11517 prep than,cells
R3396 T11519 T11520 det the,retina
R3397 T11520 T11518 pobj retina,than
R3398 T11521 T11520 compound WT,retina
R3399 T11522 T11509 punct ", ",has
R3400 T11523 T11524 mark although,are
R3401 T11524 T11509 advcl are,has
R3402 T11525 T11526 compound cell,type
R3403 T11526 T11527 compound type,proportions
R3404 T11527 T11524 nsubj proportions,are
R3405 T11528 T11524 acomp unaffected,are
R3406 T11529 T11530 punct (,D.
R3407 T11530 T11509 meta D.,has
R3408 T11531 T11530 nmod C.,D.
R3409 T11532 T11530 cc and,D.
R3410 T11533 T11530 conj R.,D.
R3411 T11534 T11533 nmod B.,R.
R3412 T11535 T11533 punct ", ",R.
R3413 T11536 T11537 amod unpublished,data
R3414 T11537 T11533 conj data,R.
R3415 T11538 T11537 punct ),data
R3416 T11539 T11509 punct .,has
R3417 T11541 T11542 advmod Thus,attributed
R3418 T11543 T11542 punct ", ",attributed
R3419 T11544 T11545 advmod marginally,subnormal
R3420 T11545 T11546 amod subnormal,responses
R3421 T11546 T11542 nsubjpass responses,attributed
R3422 T11547 T11546 amod photopic,responses
R3423 T11548 T11546 prep in,responses
R3424 T11549 T11550 det the,retina
R3425 T11550 T11548 pobj retina,in
R3426 T11551 T11552 compound Rb,E2f1
R3427 T11552 T11554 compound E2f1,DKO
R3428 T11553 T11552 punct /,E2f1
R3429 T11554 T11550 compound DKO,retina
R3430 T11555 T11542 aux can,attributed
R3431 T11556 T11542 auxpass be,attributed
R3432 T11557 T11542 prep to,attributed
R3433 T11558 T11559 preconj both,reduction
R3434 T11559 T11557 pobj reduction,to
R3435 T11560 T11559 det a,reduction
R3436 T11561 T11559 prep of,reduction
R3437 T11562 T11563 compound cone,numbers
R3438 T11563 T11561 pobj numbers,of
R3439 T11564 T11559 prep in,reduction
R3440 T11565 T11566 compound E2f1,KO
R3441 T11566 T11567 compound KO,mice
R3442 T11567 T11564 pobj mice,in
R3443 T11568 T11567 advmod alone,mice
R3444 T11569 T11559 punct ", ",reduction
R3445 T11570 T11559 cc and,reduction
R3446 T11571 T11572 det a,reduction
R3447 T11572 T11559 conj reduction,reduction
R3448 T11573 T11572 punct “,reduction
R3449 T11574 T11572 amod genuine,reduction
R3450 T11575 T11572 punct ”,reduction
R3451 T11576 T11572 amod slight,reduction
R3452 T11577 T11572 prep in,reduction
R3453 T11578 T11579 compound cone,function
R3454 T11579 T11577 pobj function,in
R3455 T11580 T11572 amod attributable,reduction
R3456 T11581 T11580 prep to,attributable
R3457 T11582 T11583 compound Rb,loss
R3458 T11583 T11581 pobj loss,to
R3459 T11584 T11572 amod relative,reduction
R3460 T11585 T11584 prep to,relative
R3461 T11586 T11585 pobj WT,to
R3462 T11587 T11542 punct .,attributed
R3463 T11589 T11590 det This,effect
R3464 T11590 T11592 nsubj effect,relate
R3465 T11591 T11590 amod slight,effect
R3466 T11593 T11592 aux may,relate
R3467 T11594 T11592 prep to,relate
R3468 T11595 T11596 det a,defect
R3469 T11596 T11594 pobj defect,to
R3470 T11597 T11596 amod true,defect
R3471 T11598 T11596 compound differentiation,defect
R3472 T11599 T11592 prep in,relate
R3473 T11600 T11601 det a,subset
R3474 T11601 T11599 pobj subset,in
R3475 T11602 T11601 prep of,subset
R3476 T11603 T11604 amod amacrine,cells
R3477 T11604 T11602 pobj cells,of
R3478 T11605 T11601 acl discussed,subset
R3479 T11606 T11605 advmod below,discussed
R3480 T11607 T11592 punct .,relate
R3481 T11609 T11610 det This,discussion
R3482 T11610 T11611 nsubj discussion,obscure
R3483 T11612 T11611 aux should,obscure
R3484 T11613 T11611 neg not,obscure
R3485 T11614 T11615 det the,outcome
R3486 T11615 T11611 dobj outcome,obscure
R3487 T11616 T11615 amod major,outcome
R3488 T11617 T11618 mark that,recovers
R3489 T11618 T11615 acl recovers,outcome
R3490 T11619 T11620 compound E2f1,deletion
R3491 T11620 T11618 nsubj deletion,recovers
R3492 T11621 T11618 dobj most,recovers
R3493 T11622 T11621 prep of,most
R3494 T11623 T11624 det the,response
R3495 T11624 T11622 pobj response,of
R3496 T11625 T11624 compound ERG,response
R3497 T11626 T11611 punct .,obscure
R3498 T11628 T11629 advmod Thus,deletion
R3499 T11630 T11629 punct ", ",deletion
R3500 T11631 T11629 compound E2f1,deletion
R3501 T11632 T11629 preconj not,deletion
R3502 T11633 T11632 advmod only,not
R3503 T11634 T11629 conj rescues,deletion
R3504 T11635 T11634 dobj morphology,rescues
R3505 T11636 T11635 cc but,morphology
R3506 T11637 T11636 advmod also,but
R3507 T11638 T11639 preconj both,rod
R3508 T11639 T11640 nmod rod,function
R3509 T11640 T11635 conj function,morphology
R3510 T11641 T11639 cc and,rod
R3511 T11642 T11639 conj cone,rod
R3512 T11643 T11640 compound system,function
R3513 T11644 T11634 prep in,rescues
R3514 T11645 T11646 det the,retina
R3515 T11646 T11644 pobj retina,in
R3516 T11647 T11648 compound Rb,KO
R3517 T11648 T11646 compound KO,retina
R3518 T11649 T11634 punct .,rescues

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T10899 23-25 PR_EXT:000013773 denotes Rb
T10900 26-30 PR_EXT:000006852 denotes E2f1
T10901 35-41 UBERON:0000966 denotes Retina
T10902 61-65 PR_EXT:000006852 denotes E2f1
T10903 71-78 SO_EXT:sequence_rescue_process denotes rescues
T10904 102-104 PR_EXT:000013773 denotes Rb
T10905 108-115 CL:0000540 denotes neurons
T10906 138-140 PR_EXT:000013773 denotes Rb
T10907 155-163 GO:0065007 denotes regulate
T10908 164-179 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T10909 198-201 PR_EXT:E2F denotes E2f
T10910 295-310 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T10911 363-368 UBERON:0007023 denotes adult
T10912 369-371 SO_EXT:wild_type_entity_or_quality denotes WT
T10913 381-385 PR_EXT:000006852 denotes E2f1
T10914 385-386 SO_EXT:sequence_nullness_or_absence denotes −
T10915 387-388 SO_EXT:sequence_nullness_or_absence denotes −
T10916 396-398 PR_EXT:000013773 denotes Rb
T10917 398-402 SO_EXT:0000346 denotes loxP
T10918 403-407 SO_EXT:0000346 denotes loxP
T10919 419-421 PR_EXT:000013773 denotes Rb
T10920 421-425 SO_EXT:0000346 denotes loxP
T10921 426-430 SO_EXT:0000346 denotes loxP
T10922 431-435 PR_EXT:000006852 denotes E2f1
T10923 435-436 SO_EXT:sequence_nullness_or_absence denotes −
T10924 437-438 SO_EXT:sequence_nullness_or_absence denotes −
T10925 439-443 NCBITaxon:10088 denotes mice
T10926 470-487 GO:0007602 denotes visual signalling
T10927 495-504 NCBITaxon:40674 denotes mammalian
T10928 505-511 UBERON:0000966 denotes retina
T10929 517-531 CL:0000210 denotes photoreceptors
T10930 535-549 CL:0000561 denotes amacrine cells
T10931 544-549 CL_GO_EXT:cell denotes cells
T10932 567-574 UBERON:0000045 denotes gangion
T10933 567-580 CL:0000740 denotes gangion cells
T10934 575-580 CL_GO_EXT:cell denotes cells
T10935 604-607 _FRAGMENT denotes rod
T10936 617-630 CL:0000751 denotes bipolar cells
T10937 612-630 CL:0000752 denotes cone bipolar cells
T10938 625-630 CL_GO_EXT:cell denotes cells
T10939 708-722 CL:0000210 denotes photoreceptors
T10940 799-812 _FRAGMENT denotes activation of
T10941 824-829 GO:0001775 denotes cells
T10942 813-829 CL:0000749 denotes ON bipolar cells
T10943 824-829 CL_GO_EXT:cell denotes cells
T10944 844-853 GO_EXT:reaction_or_response denotes Responses
T10945 870-882 GO:1990603 denotes dark-adapted
T10946 884-892 GO:1990603 denotes scotopic
T10947 929-932 CL:0000604 denotes rod
T10948 967-969 PR_EXT:000013773 denotes Rb
T10949 973-979 UBERON:0000966 denotes retina
T10950 1061-1064 _FRAGMENT denotes rod
T10951 1077-1081 CL:0000604 denotes cell
T10952 1082-1091 GO:0097473 denotes apoptosis
T10953 1069-1081 CL:0000103 denotes bipolar cell
T10954 1077-1081 CL_GO_EXT:cell denotes cell
T10955 1077-1091 GO:0006915 denotes cell apoptosis
T10956 1129-1137 GO_EXT:reaction_or_response denotes response
T10957 1216-1222 UBERON:0000966 denotes retina
T10958 1224-1233 GO_EXT:reaction_or_response denotes Responses
T10959 1261-1263 SO_EXT:wild_type_entity_or_quality denotes WT
T10960 1268-1272 PR_EXT:000006852 denotes E2f1
T10961 1276-1282 UBERON:0000966 denotes retina
T10962 1316-1318 PR_EXT:000013773 denotes Rb
T10963 1319-1323 PR_EXT:000006852 denotes E2f1
T10964 1328-1336 GO_EXT:reaction_or_response denotes response
T10965 1425-1429 PR_EXT:000006852 denotes E2f1
T10966 1430-1438 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T10967 1457-1464 SO_EXT:sequence_rescue_process denotes rescued
T10968 1469-1472 CL:0000604 denotes rod
T10969 1487-1489 PR_EXT:000013773 denotes Rb
T10970 1493-1499 UBERON:0000966 denotes retina
T10971 1501-1514 GO:0036367 denotes Light-adapted
T10972 1516-1524 GO:0036367 denotes photopic
T10973 1564-1568 CL:0000573 denotes cone
T10974 1604-1609 CL:0000573 denotes Cones
T10975 1631-1645 CL:0000210 denotes photoreceptors
T10976 1658-1662 CL:0000604 denotes rods
T10977 1680-1682 PR_EXT:000013773 denotes Rb
T10978 1701-1705 CL:0000604 denotes rods
T10979 1731-1733 PR_EXT:000013773 denotes Rb
T10980 1737-1743 UBERON:0000966 denotes retina
T10981 1785-1793 GO:0045202 denotes synaptic
T10982 1803-1816 CL:0000103 denotes bipolar cells
T10983 1811-1816 CL_GO_EXT:cell denotes cells
T10984 1845-1862 GO:0036367 denotes photopic response
T10985 1877-1881 CL:0000573 denotes cone
T10986 1893-1900 CL:0000103 denotes bipolar
T10987 1931-1933 PR_EXT:000013773 denotes Rb
T10988 1948-1955 SO_EXT:sequence_rescue_process denotes rescued
T10989 1976-1978 PR_EXT:000013773 denotes Rb
T10990 1979-1983 PR_EXT:000006852 denotes E2f1
T10991 1988-1994 UBERON:0000966 denotes retina
T10992 2064-2068 PR_EXT:000006852 denotes E2f1
T10993 2083-2100 GO:0036367 denotes photopic response
T10994 2104-2108 PR_EXT:000006852 denotes E2f1
T10995 2112-2116 NCBITaxon:10088 denotes mice
T10996 2150-2152 SO_EXT:wild_type_entity_or_quality denotes WT
T10997 2184-2188 PR_EXT:000006852 denotes E2f1
T10998 2226-2235 UBERON:0000922 denotes embryonic
T10999 2236-2240 CL:0002672 denotes RPCs
T11000 2250-2254 PR_EXT:000006852 denotes E2f1
T11001 2258-2264 UBERON:0000966 denotes retina
T11002 2303-2308 CL_GO_EXT:cell denotes cells
T11003 2318-2320 SO_EXT:wild_type_entity_or_quality denotes WT
T11004 2321-2327 UBERON:0000966 denotes retina
T11005 2338-2342 CL_GO_EXT:cell denotes cell
T11006 2439-2457 GO:0036367 denotes photopic responses
T11007 2465-2467 PR_EXT:000013773 denotes Rb
T11008 2468-2472 PR_EXT:000006852 denotes E2f1
T11009 2477-2483 UBERON:0000966 denotes retina
T11010 2525-2529 CL:0000573 denotes cone
T11011 2541-2545 PR_EXT:000006852 denotes E2f1
T11012 2549-2553 NCBITaxon:10088 denotes mice
T11013 2597-2601 CL:0000573 denotes cone
T11014 2627-2629 PR_EXT:000013773 denotes Rb
T11015 2647-2649 SO_EXT:wild_type_entity_or_quality denotes WT
T11016 2691-2706 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T11017 2729-2743 CL:0000561 denotes amacrine cells
T11018 2738-2743 CL_GO_EXT:cell denotes cells
T11019 2819-2823 PR_EXT:000006852 denotes E2f1
T11020 2824-2832 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T11021 2858-2866 GO_EXT:reaction_or_response denotes response
T11022 2874-2878 PR_EXT:000006852 denotes E2f1
T11023 2879-2887 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T11024 2897-2904 SO_EXT:sequence_rescue_process denotes rescues
T11025 2930-2933 CL:0000604 denotes rod
T11026 2938-2942 CL:0000573 denotes cone
T11027 2966-2968 PR_EXT:000013773 denotes Rb
T11028 2972-2978 UBERON:0000966 denotes retina
R2933 T10936 T10935 _lexicallyChainedTo bipolar cells,rod
R2934 T10941 T10940 _lexicallyChainedTo cells,activation of
R2935 T10951 T10950 _lexicallyChainedTo cell,rod
R2936 T10952 T10950 _lexicallyChainedTo apoptosis,rod

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T10820 439-443 NCBITaxon:10088 denotes mice
T10821 470-487 GO:0007602 denotes visual signalling
T10822 495-504 NCBITaxon:40674 denotes mammalian
T10823 505-511 UBERON:0000966 denotes retina
T10824 517-531 CL:0000210 denotes photoreceptors
T10825 535-549 CL:0000561 denotes amacrine cells
T10826 567-574 UBERON:0000045 denotes gangion
T10827 567-580 CL:0000740 denotes gangion cells
T10828 604-607 _FRAGMENT denotes rod
T10803 23-25 PR:000013773 denotes Rb
T10804 26-30 PR:000006852 denotes E2f1
T10805 35-41 UBERON:0000966 denotes Retina
T10806 61-65 PR:000006852 denotes E2f1
T10807 102-104 PR:000013773 denotes Rb
T10808 108-115 CL:0000540 denotes neurons
T10809 138-140 PR:000013773 denotes Rb
T10810 155-163 GO:0065007 denotes regulate
T10811 363-368 UBERON:0007023 denotes adult
T10812 381-385 PR:000006852 denotes E2f1
T10813 396-398 PR:000013773 denotes Rb
T10814 398-402 SO:0000346 denotes loxP
T10815 403-407 SO:0000346 denotes loxP
T10816 419-421 PR:000013773 denotes Rb
T10817 421-425 SO:0000346 denotes loxP
T10818 426-430 SO:0000346 denotes loxP
T10819 431-435 PR:000006852 denotes E2f1
T10829 617-630 CL:0000751 denotes bipolar cells
T10830 612-630 CL:0000752 denotes cone bipolar cells
T10831 708-722 CL:0000210 denotes photoreceptors
T10832 799-812 _FRAGMENT denotes activation of
T10833 824-829 GO:0001775 denotes cells
T10834 813-829 CL:0000749 denotes ON bipolar cells
T10835 870-882 GO:1990603 denotes dark-adapted
T10836 884-892 GO:1990603 denotes scotopic
T10837 929-932 CL:0000604 denotes rod
T10838 967-969 PR:000013773 denotes Rb
T10839 973-979 UBERON:0000966 denotes retina
T10840 1061-1064 _FRAGMENT denotes rod
T10841 1077-1081 CL:0000604 denotes cell
T10842 1082-1091 GO:0097473 denotes apoptosis
T10843 1069-1081 CL:0000103 denotes bipolar cell
T10844 1077-1091 GO:0006915 denotes cell apoptosis
T10845 1216-1222 UBERON:0000966 denotes retina
T10846 1268-1272 PR:000006852 denotes E2f1
T10847 1276-1282 UBERON:0000966 denotes retina
T10848 1316-1318 PR:000013773 denotes Rb
T10849 1319-1323 PR:000006852 denotes E2f1
T10850 1425-1429 PR:000006852 denotes E2f1
T10851 1469-1472 CL:0000604 denotes rod
T10852 1487-1489 PR:000013773 denotes Rb
T10853 1493-1499 UBERON:0000966 denotes retina
T10854 1501-1514 GO:0036367 denotes Light-adapted
T10855 1516-1524 GO:0036367 denotes photopic
T10856 1564-1568 CL:0000573 denotes cone
T10857 1604-1609 CL:0000573 denotes Cones
T10858 1631-1645 CL:0000210 denotes photoreceptors
T10859 1658-1662 CL:0000604 denotes rods
T10860 1680-1682 PR:000013773 denotes Rb
T10861 1701-1705 CL:0000604 denotes rods
T10862 1731-1733 PR:000013773 denotes Rb
T10863 1737-1743 UBERON:0000966 denotes retina
T10864 1785-1793 GO:0045202 denotes synaptic
T10865 1803-1816 CL:0000103 denotes bipolar cells
T10866 1845-1862 GO:0036367 denotes photopic response
T10867 1877-1881 CL:0000573 denotes cone
T10868 1893-1900 CL:0000103 denotes bipolar
T10869 1931-1933 PR:000013773 denotes Rb
T10870 1976-1978 PR:000013773 denotes Rb
T10871 1979-1983 PR:000006852 denotes E2f1
T10872 1988-1994 UBERON:0000966 denotes retina
T10873 2064-2068 PR:000006852 denotes E2f1
T10874 2083-2100 GO:0036367 denotes photopic response
T10875 2104-2108 PR:000006852 denotes E2f1
T10876 2112-2116 NCBITaxon:10088 denotes mice
T10877 2184-2188 PR:000006852 denotes E2f1
T10878 2226-2235 UBERON:0000922 denotes embryonic
T10879 2236-2240 CL:0002672 denotes RPCs
T10880 2250-2254 PR:000006852 denotes E2f1
T10881 2258-2264 UBERON:0000966 denotes retina
T10882 2321-2327 UBERON:0000966 denotes retina
T10883 2439-2457 GO:0036367 denotes photopic responses
T10884 2465-2467 PR:000013773 denotes Rb
T10885 2468-2472 PR:000006852 denotes E2f1
T10886 2477-2483 UBERON:0000966 denotes retina
T10887 2525-2529 CL:0000573 denotes cone
T10888 2541-2545 PR:000006852 denotes E2f1
T10889 2549-2553 NCBITaxon:10088 denotes mice
T10890 2597-2601 CL:0000573 denotes cone
T10891 2627-2629 PR:000013773 denotes Rb
T10892 2729-2743 CL:0000561 denotes amacrine cells
T10893 2819-2823 PR:000006852 denotes E2f1
T10894 2874-2878 PR:000006852 denotes E2f1
T10895 2930-2933 CL:0000604 denotes rod
T10896 2938-2942 CL:0000573 denotes cone
T10897 2966-2968 PR:000013773 denotes Rb
T10898 2972-2978 UBERON:0000966 denotes retina
R2929 T10829 T10828 _lexicallyChainedTo bipolar cells,rod
R2930 T10833 T10832 _lexicallyChainedTo cells,activation of
R2931 T10841 T10840 _lexicallyChainedTo cell,rod
R2932 T10842 T10840 _lexicallyChainedTo apoptosis,rod

2_test

Id Subject Object Predicate Lexical cue
17608565-9420334-84868979 224-226 9420334 denotes 30
17608565-8381715-84868979 224-226 8381715 denotes 30
17608565-11545733-84868979 224-226 11545733 denotes 30
17608565-8946919-84868979 224-226 8946919 denotes 30
17608565-15193257-84868980 1093-1094 15193257 denotes 2
17608565-15193257-84868981 1837-1838 15193257 denotes 2
T28719 224-226 9420334 denotes 30
T5228 224-226 8381715 denotes 30
T83773 224-226 11545733 denotes 30
T51839 224-226 8946919 denotes 30
T23743 1093-1094 15193257 denotes 2
T30099 1837-1838 15193257 denotes 2