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PMC:1914394 / 137-1702 JSONTXT

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Id Subject Object Predicate Lexical cue
T639 0-2 PRP denotes It
T640 17-22 VBN denotes known
T641 3-6 VBZ denotes has
T642 7-11 RB denotes long
T643 12-16 VBN denotes been
T644 23-27 IN denotes that
T645 68-76 VBZ denotes perturbs
T646 28-32 NN denotes loss
T647 33-35 IN denotes of
T648 36-39 DT denotes the
T649 55-62 NN denotes protein
T650 40-54 NN denotes retinoblastoma
T651 63-64 -LRB- denotes (
T652 64-66 NN denotes Rb
T653 66-67 -RRB- denotes )
T654 77-83 JJ denotes neural
T655 84-99 NN denotes differentiation
T656 99-101 , denotes ,
T657 101-104 CC denotes but
T658 105-108 DT denotes the
T659 120-129 NN denotes mechanism
T660 109-119 JJ denotes underlying
T661 145-151 VBN denotes solved
T662 130-133 VBZ denotes has
T663 134-139 RB denotes never
T664 140-144 VBN denotes been
T665 151-152 . denotes .
T666 152-272 sentence denotes Rb absence impairs cell cycle exit and triggers death of some neurons, so differentiation defects may well be indirect.
T667 153-155 NN denotes Rb
T668 156-163 NN denotes absence
T669 164-171 VBZ denotes impairs
T670 260-262 VB denotes be
T671 172-176 NN denotes cell
T672 177-182 NN denotes cycle
T673 183-187 NN denotes exit
T674 188-191 CC denotes and
T675 192-200 VBZ denotes triggers
T676 201-206 NN denotes death
T677 207-209 IN denotes of
T678 210-214 DT denotes some
T679 215-222 NNS denotes neurons
T680 222-224 , denotes ,
T681 224-226 RB denotes so
T682 227-242 NN denotes differentiation
T683 243-250 NNS denotes defects
T684 251-254 MD denotes may
T685 255-259 RB denotes well
T686 263-271 JJ denotes indirect
T687 271-272 . denotes .
T688 272-528 sentence denotes Indeed, we show that abnormalities in both differentiation and light-evoked electrophysiological responses in Rb-deficient retinal cells are rescued when ectopic division and apoptosis are blocked specifically by deleting E2f transcription factor (E2f) 1.
T689 273-279 RB denotes Indeed
T690 284-288 VBP denotes show
T691 279-281 , denotes ,
T692 281-283 PRP denotes we
T693 289-293 IN denotes that
T694 414-421 VBN denotes rescued
T695 294-307 NNS denotes abnormalities
T696 308-310 IN denotes in
T697 311-315 CC denotes both
T698 316-331 NN denotes differentiation
T699 342-348 VBN denotes evoked
T700 332-335 CC denotes and
T701 336-341 NN denotes light
T702 341-342 HYPH denotes -
T703 370-379 NNS denotes responses
T704 349-369 JJ denotes electrophysiological
T705 380-382 IN denotes in
T706 383-385 NN denotes Rb
T707 386-395 JJ denotes deficient
T708 385-386 HYPH denotes -
T709 404-409 NNS denotes cells
T710 396-403 JJ denotes retinal
T711 410-413 VBP denotes are
T712 422-426 WRB denotes when
T713 462-469 VBN denotes blocked
T714 427-434 JJ denotes ectopic
T715 435-443 NN denotes division
T716 444-447 CC denotes and
T717 448-457 NN denotes apoptosis
T718 458-461 VBP denotes are
T719 470-482 RB denotes specifically
T720 483-485 IN denotes by
T721 486-494 VBG denotes deleting
T722 495-498 NN denotes E2f
T723 513-519 NN denotes factor
T724 499-512 NN denotes transcription
T725 520-521 -LRB- denotes (
T726 521-524 NN denotes E2f
T727 524-525 -RRB- denotes )
T728 526-527 CD denotes 1
T729 527-528 . denotes .
T730 528-814 sentence denotes However, comprehensive cell-type analysis of the rescued double-null retina exposed cell-cycle–independent differentiation defects specifically in starburst amacrine cells (SACs), cholinergic interneurons critical in direction selectivity and developmentally important rhythmic bursts.
T731 529-536 RB denotes However
T732 605-612 VBD denotes exposed
T733 536-538 , denotes ,
T734 538-551 JJ denotes comprehensive
T735 562-570 NN denotes analysis
T736 552-556 NN denotes cell
T737 557-561 NN denotes type
T738 556-557 HYPH denotes -
T739 571-573 IN denotes of
T740 574-577 DT denotes the
T741 598-604 NN denotes retina
T742 578-585 VBN denotes rescued
T743 586-592 JJ denotes double
T744 593-597 JJ denotes null
T745 592-593 HYPH denotes -
T746 613-617 NN denotes cell
T747 618-623 NN denotes cycle
T748 617-618 HYPH denotes -
T749 624-635 JJ denotes independent
T750 623-624 HYPH denotes –
T751 652-659 NNS denotes defects
T752 636-651 NN denotes differentiation
T753 660-672 RB denotes specifically
T754 673-675 IN denotes in
T755 676-685 NN denotes starburst
T756 695-700 NNS denotes cells
T757 686-694 JJ denotes amacrine
T758 701-702 -LRB- denotes (
T759 702-706 NNS denotes SACs
T760 706-707 -RRB- denotes )
T761 707-709 , denotes ,
T762 709-720 JJ denotes cholinergic
T763 721-733 NNS denotes interneurons
T764 734-742 JJ denotes critical
T765 743-745 IN denotes in
T766 746-755 NN denotes direction
T767 756-767 NN denotes selectivity
T768 768-771 CC denotes and
T769 772-787 RB denotes developmentally
T770 788-797 JJ denotes important
T771 807-813 NNS denotes bursts
T772 798-806 JJ denotes rhythmic
T773 813-814 . denotes .
T774 814-949 sentence denotes Typically, Rb is thought to block division by repressing E2fs, but to promote differentiation by potentiating tissue-specific factors.
T775 815-824 RB denotes Typically
T776 832-839 VBN denotes thought
T777 824-826 , denotes ,
T778 826-828 NN denotes Rb
T779 829-831 VBZ denotes is
T780 840-842 TO denotes to
T781 843-848 VB denotes block
T782 849-857 NN denotes division
T783 858-860 IN denotes by
T784 861-871 VBG denotes repressing
T785 872-876 NNS denotes E2fs
T786 876-878 , denotes ,
T787 878-881 CC denotes but
T788 882-884 TO denotes to
T789 885-892 VB denotes promote
T790 893-908 NN denotes differentiation
T791 909-911 IN denotes by
T792 912-924 VBG denotes potentiating
T793 925-931 NN denotes tissue
T794 932-940 JJ denotes specific
T795 931-932 HYPH denotes -
T796 941-948 NNS denotes factors
T797 948-949 . denotes .
T798 949-1031 sentence denotes Remarkably, however, Rb promotes SAC differentiation by inhibiting E2f3 activity.
T799 950-960 RB denotes Remarkably
T800 974-982 VBZ denotes promotes
T801 960-962 , denotes ,
T802 962-969 RB denotes however
T803 969-971 , denotes ,
T804 971-973 NN denotes Rb
T805 983-986 NN denotes SAC
T806 987-1002 NN denotes differentiation
T807 1003-1005 IN denotes by
T808 1006-1016 VBG denotes inhibiting
T809 1017-1021 NN denotes E2f3
T810 1022-1030 NN denotes activity
T811 1030-1031 . denotes .
T812 1031-1166 sentence denotes Two E2f3 isoforms exist, and we find both in the developing retina, although intriguingly they show distinct subcellular distribution.
T813 1032-1035 CD denotes Two
T814 1041-1049 NNS denotes isoforms
T815 1036-1040 NN denotes E2f3
T816 1050-1055 VBP denotes exist
T817 1055-1057 , denotes ,
T818 1057-1060 CC denotes and
T819 1061-1063 PRP denotes we
T820 1064-1068 VBP denotes find
T821 1069-1073 DT denotes both
T822 1074-1076 IN denotes in
T823 1077-1080 DT denotes the
T824 1092-1098 NN denotes retina
T825 1081-1091 VBG denotes developing
T826 1098-1100 , denotes ,
T827 1100-1108 IN denotes although
T828 1127-1131 VBP denotes show
T829 1109-1121 RB denotes intriguingly
T830 1122-1126 PRP denotes they
T831 1132-1140 JJ denotes distinct
T832 1153-1165 NN denotes distribution
T833 1141-1152 JJ denotes subcellular
T834 1165-1166 . denotes .
T835 1166-1226 sentence denotes E2f3b is thought to mediate Rb function in quiescent cells.
T836 1167-1172 NN denotes E2f3b
T837 1176-1183 VBN denotes thought
T838 1173-1175 VBZ denotes is
T839 1184-1186 TO denotes to
T840 1187-1194 VB denotes mediate
T841 1195-1197 NN denotes Rb
T842 1198-1206 NN denotes function
T843 1207-1209 IN denotes in
T844 1210-1219 JJ denotes quiescent
T845 1220-1225 NNS denotes cells
T846 1225-1226 . denotes .
T847 1226-1378 sentence denotes However, in what is to our knowledge the first work to dissect E2f isoform function in vivo we show that Rb promotes SAC differentiation through E2f3a.
T848 1227-1234 RB denotes However
T849 1322-1326 VBP denotes show
T850 1234-1236 , denotes ,
T851 1236-1238 IN denotes in
T852 1239-1243 WP denotes what
T853 1244-1246 VBZ denotes is
T854 1247-1249 IN denotes to
T855 1250-1253 PRP$ denotes our
T856 1254-1263 NN denotes knowledge
T857 1264-1267 DT denotes the
T858 1274-1278 NN denotes work
T859 1268-1273 JJ denotes first
T860 1279-1281 TO denotes to
T861 1282-1289 VB denotes dissect
T862 1290-1293 NN denotes E2f
T863 1302-1310 NN denotes function
T864 1294-1301 NN denotes isoform
T865 1311-1313 FW denotes in
T866 1314-1318 FW denotes vivo
T867 1319-1321 PRP denotes we
T868 1327-1331 IN denotes that
T869 1335-1343 VBZ denotes promotes
T870 1332-1334 NN denotes Rb
T871 1344-1347 NN denotes SAC
T872 1348-1363 NN denotes differentiation
T873 1364-1371 IN denotes through
T874 1372-1377 NN denotes E2f3a
T875 1377-1378 . denotes .
T876 1378-1565 sentence denotes These data reveal a mechanism through which Rb regulates neural differentiation directly, and, unexpectedly, it involves inhibition of E2f3a, not potentiation of tissue-specific factors.
T877 1379-1384 DT denotes These
T878 1385-1389 NNS denotes data
T879 1390-1396 VBP denotes reveal
T880 1397-1398 DT denotes a
T881 1399-1408 NN denotes mechanism
T882 1409-1416 IN denotes through
T883 1426-1435 VBZ denotes regulates
T884 1417-1422 WDT denotes which
T885 1423-1425 NN denotes Rb
T886 1436-1442 JJ denotes neural
T887 1443-1458 NN denotes differentiation
T888 1459-1467 RB denotes directly
T889 1467-1469 , denotes ,
T890 1469-1472 CC denotes and
T891 1472-1474 , denotes ,
T892 1474-1486 RB denotes unexpectedly
T893 1491-1499 VBZ denotes involves
T894 1486-1488 , denotes ,
T895 1488-1490 PRP denotes it
T896 1500-1510 NN denotes inhibition
T897 1511-1513 IN denotes of
T898 1514-1519 NN denotes E2f3a
T899 1519-1521 , denotes ,
T900 1521-1524 RB denotes not
T901 1525-1537 NN denotes potentiation
T902 1538-1540 IN denotes of
T903 1541-1547 NN denotes tissue
T904 1548-1556 JJ denotes specific
T905 1547-1548 HYPH denotes -
T906 1557-1564 NNS denotes factors
T907 1564-1565 . denotes .
R21 T641 T640 aux has,known
R20 T639 T640 nsubjpass It,known
R22 T642 T640 advmod long,known
R23 T643 T640 auxpass been,known
R24 T644 T645 mark that,perturbs
R25 T645 T640 ccomp perturbs,known
R26 T646 T645 nsubj loss,perturbs
R27 T647 T646 prep of,loss
R28 T648 T649 det the,protein
R29 T649 T647 pobj protein,of
R30 T650 T649 compound retinoblastoma,protein
R31 T651 T649 punct (,protein
R32 T652 T649 appos Rb,protein
R33 T653 T645 punct ),perturbs
R34 T654 T655 amod neural,differentiation
R35 T655 T645 dobj differentiation,perturbs
R36 T656 T640 punct ", ",known
R37 T657 T640 cc but,known
R38 T658 T659 det the,mechanism
R39 T659 T661 nsubjpass mechanism,solved
R40 T660 T659 amod underlying,mechanism
R41 T661 T640 conj solved,known
R42 T662 T661 aux has,solved
R43 T663 T661 neg never,solved
R44 T664 T661 auxpass been,solved
R45 T665 T661 punct .,solved
R46 T667 T668 compound Rb,absence
R47 T668 T669 nsubj absence,impairs
R48 T669 T670 ccomp impairs,be
R49 T671 T672 compound cell,cycle
R50 T672 T673 compound cycle,exit
R51 T673 T669 dobj exit,impairs
R52 T674 T669 cc and,impairs
R53 T675 T669 conj triggers,impairs
R54 T676 T675 dobj death,triggers
R55 T677 T676 prep of,death
R56 T678 T679 det some,neurons
R57 T679 T677 pobj neurons,of
R58 T680 T670 punct ", ",be
R59 T681 T670 advmod so,be
R60 T682 T683 compound differentiation,defects
R61 T683 T670 nsubj defects,be
R62 T684 T670 aux may,be
R63 T685 T670 advmod well,be
R64 T686 T670 acomp indirect,be
R65 T687 T670 punct .,be
R66 T689 T690 advmod Indeed,show
R67 T691 T690 punct ", ",show
R68 T692 T690 nsubj we,show
R69 T693 T694 mark that,rescued
R70 T694 T690 ccomp rescued,show
R71 T695 T694 nsubjpass abnormalities,rescued
R72 T696 T695 prep in,abnormalities
R73 T697 T698 preconj both,differentiation
R74 T698 T699 npadvmod differentiation,evoked
R75 T699 T703 amod evoked,responses
R76 T700 T698 cc and,differentiation
R77 T701 T698 conj light,differentiation
R78 T702 T699 punct -,evoked
R79 T703 T696 pobj responses,in
R80 T704 T703 amod electrophysiological,responses
R81 T705 T695 prep in,abnormalities
R82 T706 T707 npadvmod Rb,deficient
R83 T707 T709 amod deficient,cells
R84 T708 T707 punct -,deficient
R85 T709 T705 pobj cells,in
R86 T710 T709 amod retinal,cells
R87 T711 T694 auxpass are,rescued
R88 T712 T713 advmod when,blocked
R89 T713 T694 advcl blocked,rescued
R90 T714 T715 amod ectopic,division
R91 T715 T713 nsubjpass division,blocked
R92 T716 T715 cc and,division
R93 T717 T715 conj apoptosis,division
R94 T718 T713 auxpass are,blocked
R95 T719 T713 advmod specifically,blocked
R96 T720 T713 prep by,blocked
R97 T721 T720 pcomp deleting,by
R98 T722 T723 compound E2f,factor
R99 T723 T721 dobj factor,deleting
R100 T724 T723 compound transcription,factor
R101 T725 T723 punct (,factor
R102 T726 T723 appos E2f,factor
R103 T727 T723 punct ),factor
R104 T728 T723 nummod 1,factor
R105 T729 T690 punct .,show
R106 T731 T732 advmod However,exposed
R107 T733 T732 punct ", ",exposed
R108 T734 T735 amod comprehensive,analysis
R109 T735 T732 nsubj analysis,exposed
R110 T736 T737 compound cell,type
R111 T737 T735 compound type,analysis
R112 T738 T737 punct -,type
R113 T739 T735 prep of,analysis
R114 T740 T741 det the,retina
R115 T741 T739 pobj retina,of
R116 T742 T741 amod rescued,retina
R117 T743 T744 amod double,null
R118 T744 T741 amod null,retina
R119 T745 T744 punct -,null
R120 T746 T747 compound cell,cycle
R121 T747 T749 npadvmod cycle,independent
R122 T748 T747 punct -,cycle
R123 T749 T751 amod independent,defects
R124 T750 T749 punct –,independent
R125 T751 T732 dobj defects,exposed
R126 T752 T751 compound differentiation,defects
R127 T753 T754 advmod specifically,in
R128 T754 T732 prep in,exposed
R129 T755 T756 nmod starburst,cells
R130 T756 T754 pobj cells,in
R131 T757 T756 amod amacrine,cells
R132 T758 T756 punct (,cells
R133 T759 T756 appos SACs,cells
R134 T760 T756 punct ),cells
R135 T761 T756 punct ", ",cells
R136 T762 T763 amod cholinergic,interneurons
R137 T763 T756 appos interneurons,cells
R138 T764 T763 amod critical,interneurons
R139 T765 T764 prep in,critical
R140 T766 T767 compound direction,selectivity
R141 T767 T765 pobj selectivity,in
R142 T768 T767 cc and,selectivity
R143 T769 T770 advmod developmentally,important
R144 T770 T771 amod important,bursts
R145 T771 T767 conj bursts,selectivity
R146 T772 T771 amod rhythmic,bursts
R147 T773 T732 punct .,exposed
R148 T775 T776 advmod Typically,thought
R149 T777 T776 punct ", ",thought
R150 T778 T776 nsubjpass Rb,thought
R151 T779 T776 auxpass is,thought
R152 T780 T781 aux to,block
R153 T781 T776 xcomp block,thought
R154 T782 T781 dobj division,block
R155 T783 T781 prep by,block
R156 T784 T783 pcomp repressing,by
R157 T785 T784 dobj E2fs,repressing
R158 T786 T781 punct ", ",block
R159 T787 T781 cc but,block
R160 T788 T789 aux to,promote
R161 T789 T781 conj promote,block
R162 T790 T789 dobj differentiation,promote
R163 T791 T789 prep by,promote
R164 T792 T791 pcomp potentiating,by
R165 T793 T794 npadvmod tissue,specific
R166 T794 T796 amod specific,factors
R167 T795 T794 punct -,specific
R168 T796 T792 dobj factors,potentiating
R169 T797 T776 punct .,thought
R170 T799 T800 advmod Remarkably,promotes
R171 T801 T800 punct ", ",promotes
R172 T802 T800 advmod however,promotes
R173 T803 T800 punct ", ",promotes
R174 T804 T800 nsubj Rb,promotes
R175 T805 T806 compound SAC,differentiation
R176 T806 T800 dobj differentiation,promotes
R177 T807 T800 prep by,promotes
R178 T808 T807 pcomp inhibiting,by
R179 T809 T810 compound E2f3,activity
R180 T810 T808 dobj activity,inhibiting
R181 T811 T800 punct .,promotes
R182 T813 T814 nummod Two,isoforms
R183 T814 T816 nsubj isoforms,exist
R184 T815 T814 compound E2f3,isoforms
R185 T817 T816 punct ", ",exist
R186 T818 T816 cc and,exist
R187 T819 T820 nsubj we,find
R188 T820 T816 conj find,exist
R189 T821 T820 dobj both,find
R190 T822 T820 prep in,find
R191 T823 T824 det the,retina
R192 T824 T822 pobj retina,in
R193 T825 T824 amod developing,retina
R194 T826 T820 punct ", ",find
R195 T827 T828 mark although,show
R196 T828 T820 advcl show,find
R197 T829 T828 advmod intriguingly,show
R198 T830 T828 nsubj they,show
R199 T831 T832 amod distinct,distribution
R200 T832 T828 dobj distribution,show
R201 T833 T832 amod subcellular,distribution
R202 T834 T820 punct .,find
R203 T836 T837 nsubjpass E2f3b,thought
R204 T838 T837 auxpass is,thought
R205 T839 T840 aux to,mediate
R206 T840 T837 xcomp mediate,thought
R207 T841 T842 compound Rb,function
R208 T842 T840 dobj function,mediate
R209 T843 T840 prep in,mediate
R210 T844 T845 amod quiescent,cells
R211 T845 T843 pobj cells,in
R212 T846 T837 punct .,thought
R213 T848 T849 advmod However,show
R214 T850 T849 punct ", ",show
R215 T851 T849 prep in,show
R216 T852 T853 dep what,is
R217 T853 T851 pcomp is,in
R218 T854 T853 prep to,is
R219 T855 T856 poss our,knowledge
R220 T856 T854 pobj knowledge,to
R221 T857 T858 det the,work
R222 T858 T853 attr work,is
R223 T859 T858 amod first,work
R224 T860 T861 aux to,dissect
R225 T861 T858 advcl dissect,work
R226 T862 T863 compound E2f,function
R227 T863 T861 dobj function,dissect
R228 T864 T863 compound isoform,function
R229 T865 T866 advmod in,vivo
R230 T866 T861 advmod vivo,dissect
R231 T867 T849 nsubj we,show
R232 T868 T869 mark that,promotes
R233 T869 T849 ccomp promotes,show
R234 T870 T869 nsubj Rb,promotes
R235 T871 T872 compound SAC,differentiation
R236 T872 T869 dobj differentiation,promotes
R237 T873 T869 prep through,promotes
R238 T874 T873 pobj E2f3a,through
R239 T875 T849 punct .,show
R240 T877 T878 det These,data
R241 T878 T879 nsubj data,reveal
R242 T880 T881 det a,mechanism
R243 T881 T879 dobj mechanism,reveal
R244 T882 T883 prep through,regulates
R245 T883 T881 relcl regulates,mechanism
R246 T884 T882 pobj which,through
R247 T885 T883 nsubj Rb,regulates
R248 T886 T887 amod neural,differentiation
R249 T887 T883 dobj differentiation,regulates
R250 T888 T883 advmod directly,regulates
R251 T889 T879 punct ", ",reveal
R252 T890 T879 cc and,reveal
R253 T891 T879 punct ", ",reveal
R254 T892 T893 advmod unexpectedly,involves
R255 T893 T879 conj involves,reveal
R256 T894 T893 punct ", ",involves
R257 T895 T893 nsubj it,involves
R258 T896 T893 dobj inhibition,involves
R259 T897 T896 prep of,inhibition
R260 T898 T897 pobj E2f3a,of
R261 T899 T896 punct ", ",inhibition
R262 T900 T896 neg not,inhibition
R263 T901 T896 appos potentiation,inhibition
R264 T902 T901 prep of,potentiation
R265 T903 T904 npadvmod tissue,specific
R266 T904 T906 amod specific,factors
R267 T905 T904 punct -,specific
R268 T906 T902 pobj factors,of
R269 T907 T893 punct .,involves

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T559 40-62 PR_EXT:000013773 denotes retinoblastoma protein
T560 55-62 CHEBI_PR_EXT:protein denotes protein
T561 64-66 PR_EXT:000013773 denotes Rb
T562 77-83 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes neural
T563 84-99 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T564 153-155 PR_EXT:000013773 denotes Rb
T565 172-176 CL_GO_EXT:cell denotes cell
T566 172-182 GO:0007049 denotes cell cycle
T568 201-209,215-222 GO:0070997 denotes death of neurons
T569 215-222 CL:0000540 denotes neurons
T570 227-242 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T571 316-331 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T573 370-382,404-409 GO:0051716 denotes responses in cells
T574 383-385 PR_EXT:000013773 denotes Rb
T575 396-403 UBERON:0000966 denotes retinal
T576 396-409 CL:0009004 denotes retinal cells
T577 404-409 CL_GO_EXT:cell denotes cells
T578 414-421 SO_EXT:sequence_rescue_process denotes rescued
T579 448-457 GO:0006915 denotes apoptosis
T580 486-494 SO_EXT:sequence_deletion_process denotes deleting
T582 521-524,495-519,526-527 PR_EXT:000006852 denotes E2f E2f transcription factor 1
T583 499-512 GO_EXT:transcription denotes transcription
T584 499-519 GO_EXT:transcription_factor denotes transcription factor
T586 552-556 CL_GO_EXT:cell denotes cell
T587 578-585 SO_EXT:sequence_rescue_process denotes rescued
T588 593-597 SO_EXT:sequence_nullness denotes null
T589 598-604 UBERON:0000966 denotes retina
T590 613-617 CL_GO_EXT:cell denotes cell
T591 613-623 GO:0007049 denotes cell-cycle
T592 636-651 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T593 686-700 CL:0000561 denotes amacrine cells
T594 695-700 CL_GO_EXT:cell denotes cells
T595 709-720 CHEBI:15355 denotes cholinergic
T596 721-733 CL:0000099 denotes interneurons
T597 826-828 PR_EXT:000013773 denotes Rb
T598 872-876 PR_EXT:E2F denotes E2fs
T599 893-908 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T600 925-931 UBERON:0000479 denotes tissue
T601 971-973 PR_EXT:000013773 denotes Rb
T602 987-1002 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T603 1017-1021 PR_EXT:000006854 denotes E2f3
T604 1036-1040 PR_EXT:000006854 denotes E2f3
T605 1041-1049 SO_EXT:0001060 denotes isoforms
T606 1092-1098 UBERON:0000966 denotes retina
T607 1141-1152 GO_UBERON_EXT:cellular_component_or_cell_part denotes subcellular
T608 1144-1152 CL_GO_EXT:cell denotes cellular
T609 1195-1197 PR_EXT:000013773 denotes Rb
T610 1210-1219 GO:0044838 denotes quiescent
T611 1220-1225 CL_GO_EXT:cell denotes cells
T612 1290-1293 PR_EXT:E2F denotes E2f
T613 1294-1301 SO_EXT:0001060 denotes isoform
T614 1332-1334 PR_EXT:000013773 denotes Rb
T615 1348-1363 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T616 1372-1377 PR_EXT:000028775 denotes E2f3a
T617 1423-1425 PR_EXT:000013773 denotes Rb
T618 1426-1435 GO:0065007 denotes regulates
T619 1436-1442 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes neural
T620 1443-1458 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T621 1514-1519 PR_EXT:000028775 denotes E2f3a
T622 1541-1547 UBERON:0000479 denotes tissue

craft-ca-core-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T515 40-62 PR:000013773 denotes retinoblastoma protein
T516 64-66 PR:000013773 denotes Rb
T517 153-155 PR:000013773 denotes Rb
T518 172-182 GO:0007049 denotes cell cycle
T520 201-209,215-222 GO:0070997 denotes death of neurons
T521 215-222 CL:0000540 denotes neurons
T523 370-382,404-409 GO:0051716 denotes responses in cells
T524 383-385 PR:000013773 denotes Rb
T525 396-403 UBERON:0000966 denotes retinal
T526 396-409 CL:0009004 denotes retinal cells
T527 448-457 GO:0006915 denotes apoptosis
T529 521-524,495-519,526-527 PR:000006852 denotes E2f E2f transcription factor 1
T531 598-604 UBERON:0000966 denotes retina
T532 613-623 GO:0007049 denotes cell-cycle
T533 686-700 CL:0000561 denotes amacrine cells
T534 709-720 CHEBI:15355 denotes cholinergic
T535 721-733 CL:0000099 denotes interneurons
T536 826-828 PR:000013773 denotes Rb
T537 925-931 UBERON:0000479 denotes tissue
T538 971-973 PR:000013773 denotes Rb
T539 1017-1021 PR:000006854 denotes E2f3
T540 1036-1040 PR:000006854 denotes E2f3
T541 1041-1049 SO:0001060 denotes isoforms
T542 1092-1098 UBERON:0000966 denotes retina
T543 1195-1197 PR:000013773 denotes Rb
T544 1210-1219 GO:0044838 denotes quiescent
T545 1294-1301 SO:0001060 denotes isoform
T546 1332-1334 PR:000013773 denotes Rb
T547 1372-1377 PR:000028775 denotes E2f3a
T548 1423-1425 PR:000013773 denotes Rb
T549 1426-1435 GO:0065007 denotes regulates
T550 1514-1519 PR:000028775 denotes E2f3a
T551 1541-1547 UBERON:0000479 denotes tissue