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PMC:1914394 / 0-922 JSONTXT

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Id Subject Object Predicate Lexical cue
T625 0-87 sentence denotes Rb-Mediated Neuronal Differentiation through Cell-Cycle–Independent Regulation of E2f3a
T626 2-3 HYPH denotes -
T627 21-36 NN denotes Differentiation
T628 12-20 JJ denotes Neuronal
T629 37-44 IN denotes through
T630 45-49 NN denotes Cell
T631 50-55 NN denotes Cycle
T632 49-50 HYPH denotes -
T633 56-67 JJ denotes Independent
T634 55-56 HYPH denotes –
T635 68-78 NN denotes Regulation
T636 79-81 IN denotes of
T637 82-87 NN denotes E2f3a
T638 87-289 sentence denotes Rb Promotes Neurogenesis through E2f3a Abstract It has long been known that loss of the retinoblastoma protein (Rb) perturbs neural differentiation, but the underlying mechanism has never been solved.
T639 137-139 PRP denotes It
T640 154-159 VBN denotes known
T641 140-143 VBZ denotes has
T642 144-148 RB denotes long
T643 149-153 VBN denotes been
T644 160-164 IN denotes that
T645 205-213 VBZ denotes perturbs
T646 165-169 NN denotes loss
T647 170-172 IN denotes of
T648 173-176 DT denotes the
T649 192-199 NN denotes protein
T650 177-191 NN denotes retinoblastoma
T651 200-201 -LRB- denotes (
T652 201-203 NN denotes Rb
T653 203-204 -RRB- denotes )
T654 214-220 JJ denotes neural
T655 221-236 NN denotes differentiation
T656 236-238 , denotes ,
T657 238-241 CC denotes but
T658 242-245 DT denotes the
T659 257-266 NN denotes mechanism
T660 246-256 JJ denotes underlying
T661 282-288 VBN denotes solved
T662 267-270 VBZ denotes has
T663 271-276 RB denotes never
T664 277-281 VBN denotes been
T665 288-289 . denotes .
T666 289-409 sentence denotes Rb absence impairs cell cycle exit and triggers death of some neurons, so differentiation defects may well be indirect.
T667 290-292 NN denotes Rb
T668 293-300 NN denotes absence
T669 301-308 VBZ denotes impairs
T670 397-399 VB denotes be
T671 309-313 NN denotes cell
T672 314-319 NN denotes cycle
T673 320-324 NN denotes exit
T674 325-328 CC denotes and
T675 329-337 VBZ denotes triggers
T676 338-343 NN denotes death
T677 344-346 IN denotes of
T678 347-351 DT denotes some
T679 352-359 NNS denotes neurons
T680 359-361 , denotes ,
T681 361-363 RB denotes so
T682 364-379 NN denotes differentiation
T683 380-387 NNS denotes defects
T684 388-391 MD denotes may
T685 392-396 RB denotes well
T686 400-408 JJ denotes indirect
T687 408-409 . denotes .
T688 409-665 sentence denotes Indeed, we show that abnormalities in both differentiation and light-evoked electrophysiological responses in Rb-deficient retinal cells are rescued when ectopic division and apoptosis are blocked specifically by deleting E2f transcription factor (E2f) 1.
T689 410-416 RB denotes Indeed
T690 421-425 VBP denotes show
T691 416-418 , denotes ,
T692 418-420 PRP denotes we
T693 426-430 IN denotes that
T694 551-558 VBN denotes rescued
T695 431-444 NNS denotes abnormalities
T696 445-447 IN denotes in
T697 448-452 CC denotes both
T698 453-468 NN denotes differentiation
T699 479-485 VBN denotes evoked
T700 469-472 CC denotes and
T701 473-478 NN denotes light
T702 478-479 HYPH denotes -
T703 507-516 NNS denotes responses
T704 486-506 JJ denotes electrophysiological
T705 517-519 IN denotes in
T706 520-522 NN denotes Rb
T707 523-532 JJ denotes deficient
T708 522-523 HYPH denotes -
T709 541-546 NNS denotes cells
T710 533-540 JJ denotes retinal
T711 547-550 VBP denotes are
T712 559-563 WRB denotes when
T713 599-606 VBN denotes blocked
T714 564-571 JJ denotes ectopic
T715 572-580 NN denotes division
T716 581-584 CC denotes and
T717 585-594 NN denotes apoptosis
T718 595-598 VBP denotes are
T719 607-619 RB denotes specifically
T720 620-622 IN denotes by
T721 623-631 VBG denotes deleting
T722 632-635 NN denotes E2f
T723 650-656 NN denotes factor
T724 636-649 NN denotes transcription
T725 657-658 -LRB- denotes (
T726 658-661 NN denotes E2f
T727 661-662 -RRB- denotes )
T728 663-664 CD denotes 1
T729 664-665 . denotes .
T731 666-673 RB denotes However
T732 742-749 VBD denotes exposed
T733 673-675 , denotes ,
T734 675-688 JJ denotes comprehensive
T735 699-707 NN denotes analysis
T736 689-693 NN denotes cell
T737 694-698 NN denotes type
T738 693-694 HYPH denotes -
T739 708-710 IN denotes of
T740 711-714 DT denotes the
T741 735-741 NN denotes retina
T742 715-722 VBN denotes rescued
T743 723-729 JJ denotes double
T744 730-734 JJ denotes null
T745 729-730 HYPH denotes -
T746 750-754 NN denotes cell
T747 755-760 NN denotes cycle
T748 754-755 HYPH denotes -
T749 761-772 JJ denotes independent
T750 760-761 HYPH denotes –
T751 789-796 NNS denotes defects
T752 773-788 NN denotes differentiation
T753 797-809 RB denotes specifically
T754 810-812 IN denotes in
T755 813-822 NN denotes starburst
T756 832-837 NNS denotes cells
T757 823-831 JJ denotes amacrine
T758 838-839 -LRB- denotes (
T759 839-843 NNS denotes SACs
T760 843-844 -RRB- denotes )
T761 844-846 , denotes ,
T762 846-857 JJ denotes cholinergic
T763 858-870 NNS denotes interneurons
T764 871-879 JJ denotes critical
T765 880-882 IN denotes in
T766 883-892 NN denotes direction
T767 893-904 NN denotes selectivity
T768 905-908 CC denotes and
T623 0-2 NN denotes Rb
T624 3-11 VBN denotes Mediated
R21 T641 T640 aux has,known
R9 T626 T624 punct -,Mediated
R10 T628 T627 amod Neuronal,Differentiation
R11 T629 T627 prep through,Differentiation
R12 T630 T631 compound Cell,Cycle
R13 T631 T633 npadvmod Cycle,Independent
R14 T632 T631 punct -,Cycle
R15 T633 T635 amod Independent,Regulation
R16 T634 T633 punct –,Independent
R17 T635 T629 pobj Regulation,through
R18 T636 T635 prep of,Regulation
R19 T637 T636 pobj E2f3a,of
R20 T639 T640 nsubjpass It,known
R22 T642 T640 advmod long,known
R23 T643 T640 auxpass been,known
R24 T644 T645 mark that,perturbs
R25 T645 T640 ccomp perturbs,known
R26 T646 T645 nsubj loss,perturbs
R27 T647 T646 prep of,loss
R28 T648 T649 det the,protein
R29 T649 T647 pobj protein,of
R30 T650 T649 compound retinoblastoma,protein
R31 T651 T649 punct (,protein
R32 T652 T649 appos Rb,protein
R33 T653 T645 punct ),perturbs
R34 T654 T655 amod neural,differentiation
R35 T655 T645 dobj differentiation,perturbs
R36 T656 T640 punct ", ",known
R37 T657 T640 cc but,known
R38 T658 T659 det the,mechanism
R39 T659 T661 nsubjpass mechanism,solved
R40 T660 T659 amod underlying,mechanism
R41 T661 T640 conj solved,known
R42 T662 T661 aux has,solved
R43 T663 T661 neg never,solved
R44 T664 T661 auxpass been,solved
R45 T665 T661 punct .,solved
R46 T667 T668 compound Rb,absence
R47 T668 T669 nsubj absence,impairs
R48 T669 T670 ccomp impairs,be
R49 T671 T672 compound cell,cycle
R50 T672 T673 compound cycle,exit
R51 T673 T669 dobj exit,impairs
R52 T674 T669 cc and,impairs
R53 T675 T669 conj triggers,impairs
R54 T676 T675 dobj death,triggers
R55 T677 T676 prep of,death
R56 T678 T679 det some,neurons
R57 T679 T677 pobj neurons,of
R58 T680 T670 punct ", ",be
R59 T681 T670 advmod so,be
R60 T682 T683 compound differentiation,defects
R61 T683 T670 nsubj defects,be
R62 T684 T670 aux may,be
R63 T685 T670 advmod well,be
R64 T686 T670 acomp indirect,be
R65 T687 T670 punct .,be
R66 T689 T690 advmod Indeed,show
R67 T691 T690 punct ", ",show
R68 T692 T690 nsubj we,show
R69 T693 T694 mark that,rescued
R70 T694 T690 ccomp rescued,show
R71 T695 T694 nsubjpass abnormalities,rescued
R72 T696 T695 prep in,abnormalities
R73 T697 T698 preconj both,differentiation
R74 T698 T699 npadvmod differentiation,evoked
R75 T699 T703 amod evoked,responses
R76 T700 T698 cc and,differentiation
R77 T701 T698 conj light,differentiation
R78 T702 T699 punct -,evoked
R79 T703 T696 pobj responses,in
R80 T704 T703 amod electrophysiological,responses
R81 T705 T695 prep in,abnormalities
R82 T706 T707 npadvmod Rb,deficient
R83 T707 T709 amod deficient,cells
R84 T708 T707 punct -,deficient
R85 T709 T705 pobj cells,in
R86 T710 T709 amod retinal,cells
R87 T711 T694 auxpass are,rescued
R88 T712 T713 advmod when,blocked
R89 T713 T694 advcl blocked,rescued
R90 T714 T715 amod ectopic,division
R91 T715 T713 nsubjpass division,blocked
R92 T716 T715 cc and,division
R93 T717 T715 conj apoptosis,division
R94 T718 T713 auxpass are,blocked
R95 T719 T713 advmod specifically,blocked
R96 T720 T713 prep by,blocked
R97 T721 T720 pcomp deleting,by
R98 T722 T723 compound E2f,factor
R99 T723 T721 dobj factor,deleting
R100 T724 T723 compound transcription,factor
R101 T725 T723 punct (,factor
R102 T726 T723 appos E2f,factor
R103 T727 T723 punct ),factor
R104 T728 T723 nummod 1,factor
R105 T729 T690 punct .,show
R106 T731 T732 advmod However,exposed
R107 T733 T732 punct ", ",exposed
R108 T734 T735 amod comprehensive,analysis
R109 T735 T732 nsubj analysis,exposed
R110 T736 T737 compound cell,type
R111 T737 T735 compound type,analysis
R112 T738 T737 punct -,type
R113 T739 T735 prep of,analysis
R114 T740 T741 det the,retina
R115 T741 T739 pobj retina,of
R116 T742 T741 amod rescued,retina
R117 T743 T744 amod double,null
R118 T744 T741 amod null,retina
R119 T745 T744 punct -,null
R120 T746 T747 compound cell,cycle
R121 T747 T749 npadvmod cycle,independent
R122 T748 T747 punct -,cycle
R123 T749 T751 amod independent,defects
R124 T750 T749 punct –,independent
R125 T751 T732 dobj defects,exposed
R126 T752 T751 compound differentiation,defects
R127 T753 T754 advmod specifically,in
R128 T754 T732 prep in,exposed
R129 T755 T756 nmod starburst,cells
R130 T756 T754 pobj cells,in
R131 T757 T756 amod amacrine,cells
R132 T758 T756 punct (,cells
R133 T759 T756 appos SACs,cells
R134 T760 T756 punct ),cells
R135 T761 T756 punct ", ",cells
R136 T762 T763 amod cholinergic,interneurons
R137 T763 T756 appos interneurons,cells
R138 T764 T763 amod critical,interneurons
R139 T765 T764 prep in,critical
R140 T766 T767 compound direction,selectivity
R141 T767 T765 pobj selectivity,in
R142 T768 T767 cc and,selectivity
R270 T623 T624 npadvmod Rb,Mediated
R271 T624 T627 amod Mediated,Differentiation

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T552 0-2 PR_EXT:000013773 denotes Rb
T553 12-20 CL:0000540 denotes Neuronal
T554 21-36 GO_RO_EXT:developmental_differentiation_process denotes Differentiation
T555 45-49 CL_GO_EXT:cell denotes Cell
T556 45-55 GO:0007049 denotes Cell-Cycle
T557 68-78 GO:0065007 denotes Regulation
T558 82-87 PR_EXT:000028775 denotes E2f3a
T559 177-199 PR_EXT:000013773 denotes retinoblastoma protein
T560 192-199 CHEBI_PR_EXT:protein denotes protein
T561 201-203 PR_EXT:000013773 denotes Rb
T562 214-220 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes neural
T563 221-236 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T564 290-292 PR_EXT:000013773 denotes Rb
T565 309-313 CL_GO_EXT:cell denotes cell
T566 309-319 GO:0007049 denotes cell cycle
T567 338-346 _FRAGMENT denotes death of
T568 352-359 GO:0070997 denotes neurons
T569 352-359 CL:0000540 denotes neurons
T570 364-379 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T571 453-468 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T572 507-519 _FRAGMENT denotes responses in
T573 541-546 GO:0051716 denotes cells
T574 520-522 PR_EXT:000013773 denotes Rb
T575 533-540 UBERON:0000966 denotes retinal
T576 533-546 CL:0009004 denotes retinal cells
T577 541-546 CL_GO_EXT:cell denotes cells
T578 551-558 SO_EXT:sequence_rescue_process denotes rescued
T579 585-594 GO:0006915 denotes apoptosis
T580 623-631 SO_EXT:sequence_deletion_process denotes deleting
T581 632-656 _FRAGMENT denotes E2f transcription factor
T582 663-664 PR_EXT:000006852 denotes 1
T583 636-649 GO_EXT:transcription denotes transcription
T584 636-656 GO_EXT:transcription_factor denotes transcription factor
T585 658-661 _FRAGMENT denotes E2f
T586 689-693 CL_GO_EXT:cell denotes cell
T587 715-722 SO_EXT:sequence_rescue_process denotes rescued
T588 730-734 SO_EXT:sequence_nullness denotes null
T589 735-741 UBERON:0000966 denotes retina
T590 750-754 CL_GO_EXT:cell denotes cell
T591 750-760 GO:0007049 denotes cell-cycle
T592 773-788 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T593 823-837 CL:0000561 denotes amacrine cells
T594 832-837 CL_GO_EXT:cell denotes cells
T595 846-857 CHEBI:15355 denotes cholinergic
T596 858-870 CL:0000099 denotes interneurons
R5 T568 T567 _lexicallyChainedTo neurons,death of
R6 T573 T572 _lexicallyChainedTo cells,responses in
R7 T582 T581 _lexicallyChainedTo 1,E2f transcription factor
R8 T582 T585 _lexicallyChainedTo 1,E2f

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T510 0-2 PR:000013773 denotes Rb
T511 12-20 CL:0000540 denotes Neuronal
T512 45-55 GO:0007049 denotes Cell-Cycle
T513 68-78 GO:0065007 denotes Regulation
T514 82-87 PR:000028775 denotes E2f3a
T515 177-199 PR:000013773 denotes retinoblastoma protein
T516 201-203 PR:000013773 denotes Rb
T517 290-292 PR:000013773 denotes Rb
T518 309-319 GO:0007049 denotes cell cycle
T519 338-346 _FRAGMENT denotes death of
T520 352-359 GO:0070997 denotes neurons
T521 352-359 CL:0000540 denotes neurons
T522 507-519 _FRAGMENT denotes responses in
T523 541-546 GO:0051716 denotes cells
T524 520-522 PR:000013773 denotes Rb
T525 533-540 UBERON:0000966 denotes retinal
T526 533-546 CL:0009004 denotes retinal cells
T527 585-594 GO:0006915 denotes apoptosis
T528 632-656 _FRAGMENT denotes E2f transcription factor
T529 663-664 PR:000006852 denotes 1
T530 658-661 _FRAGMENT denotes E2f
T531 735-741 UBERON:0000966 denotes retina
T532 750-760 GO:0007049 denotes cell-cycle
T533 823-837 CL:0000561 denotes amacrine cells
T534 846-857 CHEBI:15355 denotes cholinergic
T535 858-870 CL:0000099 denotes interneurons
R1 T520 T519 _lexicallyChainedTo neurons,death of
R2 T523 T522 _lexicallyChainedTo cells,responses in
R3 T529 T528 _lexicallyChainedTo 1,E2f transcription factor
R4 T529 T530 _lexicallyChainedTo 1,E2f