PMC:1914394 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T4272	6770-6774	NN	denotes	E2f1
T625	0-87	sentence	denotes	Rb-Mediated Neuronal Differentiation through Cell-Cycle–Independent Regulation of E2f3a
T626	2-3	HYPH	denotes	-
T627	21-36	NN	denotes	Differentiation
T628	12-20	JJ	denotes	Neuronal
T629	37-44	IN	denotes	through
T630	45-49	NN	denotes	Cell
T631	50-55	NN	denotes	Cycle
T632	49-50	HYPH	denotes	-
T633	56-67	JJ	denotes	Independent
T634	55-56	HYPH	denotes	–
T635	68-78	NN	denotes	Regulation
T636	79-81	IN	denotes	of
T637	82-87	NN	denotes	E2f3a
T638	87-289	sentence	denotes	Rb Promotes Neurogenesis through E2f3a Abstract It has long been known that loss of the retinoblastoma protein (Rb) perturbs neural differentiation, but the underlying mechanism has never been solved.
T639	137-139	PRP	denotes	It
T640	154-159	VBN	denotes	known
T641	140-143	VBZ	denotes	has
T642	144-148	RB	denotes	long
T643	149-153	VBN	denotes	been
T644	160-164	IN	denotes	that
T645	205-213	VBZ	denotes	perturbs
T646	165-169	NN	denotes	loss
T647	170-172	IN	denotes	of
T648	173-176	DT	denotes	the
T649	192-199	NN	denotes	protein
T650	177-191	NN	denotes	retinoblastoma
T651	200-201	-LRB-	denotes	(
T652	201-203	NN	denotes	Rb
T653	203-204	-RRB-	denotes	)
T654	214-220	JJ	denotes	neural
T655	221-236	NN	denotes	differentiation
T656	236-238	,	denotes	,
T657	238-241	CC	denotes	but
T658	242-245	DT	denotes	the
T659	257-266	NN	denotes	mechanism
T660	246-256	JJ	denotes	underlying
T661	282-288	VBN	denotes	solved
T662	267-270	VBZ	denotes	has
T663	271-276	RB	denotes	never
T664	277-281	VBN	denotes	been
T665	288-289	.	denotes	.
T666	289-409	sentence	denotes	Rb absence impairs cell cycle exit and triggers death of some neurons, so differentiation defects may well be indirect.
T667	290-292	NN	denotes	Rb
T668	293-300	NN	denotes	absence
T669	301-308	VBZ	denotes	impairs
T670	397-399	VB	denotes	be
T671	309-313	NN	denotes	cell
T672	314-319	NN	denotes	cycle
T673	320-324	NN	denotes	exit
T674	325-328	CC	denotes	and
T675	329-337	VBZ	denotes	triggers
T676	338-343	NN	denotes	death
T677	344-346	IN	denotes	of
T678	347-351	DT	denotes	some
T679	352-359	NNS	denotes	neurons
T680	359-361	,	denotes	,
T681	361-363	RB	denotes	so
T682	364-379	NN	denotes	differentiation
T683	380-387	NNS	denotes	defects
T684	388-391	MD	denotes	may
T685	392-396	RB	denotes	well
T686	400-408	JJ	denotes	indirect
T687	408-409	.	denotes	.
T688	409-665	sentence	denotes	Indeed, we show that abnormalities in both differentiation and light-evoked electrophysiological responses in Rb-deficient retinal cells are rescued when ectopic division and apoptosis are blocked specifically by deleting E2f transcription factor (E2f) 1.
T689	410-416	RB	denotes	Indeed
T690	421-425	VBP	denotes	show
T691	416-418	,	denotes	,
T692	418-420	PRP	denotes	we
T693	426-430	IN	denotes	that
T694	551-558	VBN	denotes	rescued
T695	431-444	NNS	denotes	abnormalities
T696	445-447	IN	denotes	in
T697	448-452	CC	denotes	both
T698	453-468	NN	denotes	differentiation
T699	479-485	VBN	denotes	evoked
T700	469-472	CC	denotes	and
T701	473-478	NN	denotes	light
T702	478-479	HYPH	denotes	-
T703	507-516	NNS	denotes	responses
T704	486-506	JJ	denotes	electrophysiological
T705	517-519	IN	denotes	in
T706	520-522	NN	denotes	Rb
T707	523-532	JJ	denotes	deficient
T708	522-523	HYPH	denotes	-
T709	541-546	NNS	denotes	cells
T710	533-540	JJ	denotes	retinal
T711	547-550	VBP	denotes	are
T712	559-563	WRB	denotes	when
T713	599-606	VBN	denotes	blocked
T714	564-571	JJ	denotes	ectopic
T715	572-580	NN	denotes	division
T716	581-584	CC	denotes	and
T717	585-594	NN	denotes	apoptosis
T718	595-598	VBP	denotes	are
T719	607-619	RB	denotes	specifically
T720	620-622	IN	denotes	by
T721	623-631	VBG	denotes	deleting
T722	632-635	NN	denotes	E2f
T723	650-656	NN	denotes	factor
T724	636-649	NN	denotes	transcription
T725	657-658	-LRB-	denotes	(
T726	658-661	NN	denotes	E2f
T727	661-662	-RRB-	denotes	)
T728	663-664	CD	denotes	1
T729	664-665	.	denotes	.
T730	665-951	sentence	denotes	However, comprehensive cell-type analysis of the rescued double-null retina exposed cell-cycle–independent differentiation defects specifically in starburst amacrine cells (SACs), cholinergic interneurons critical in direction selectivity and developmentally important rhythmic bursts.
T731	666-673	RB	denotes	However
T732	742-749	VBD	denotes	exposed
T733	673-675	,	denotes	,
T734	675-688	JJ	denotes	comprehensive
T735	699-707	NN	denotes	analysis
T736	689-693	NN	denotes	cell
T737	694-698	NN	denotes	type
T738	693-694	HYPH	denotes	-
T739	708-710	IN	denotes	of
T740	711-714	DT	denotes	the
T741	735-741	NN	denotes	retina
T742	715-722	VBN	denotes	rescued
T743	723-729	JJ	denotes	double
T744	730-734	JJ	denotes	null
T745	729-730	HYPH	denotes	-
T746	750-754	NN	denotes	cell
T747	755-760	NN	denotes	cycle
T748	754-755	HYPH	denotes	-
T749	761-772	JJ	denotes	independent
T750	760-761	HYPH	denotes	–
T751	789-796	NNS	denotes	defects
T752	773-788	NN	denotes	differentiation
T753	797-809	RB	denotes	specifically
T754	810-812	IN	denotes	in
T755	813-822	NN	denotes	starburst
T756	832-837	NNS	denotes	cells
T757	823-831	JJ	denotes	amacrine
T758	838-839	-LRB-	denotes	(
T759	839-843	NNS	denotes	SACs
T760	843-844	-RRB-	denotes	)
T761	844-846	,	denotes	,
T762	846-857	JJ	denotes	cholinergic
T763	858-870	NNS	denotes	interneurons
T764	871-879	JJ	denotes	critical
T765	880-882	IN	denotes	in
T766	883-892	NN	denotes	direction
T767	893-904	NN	denotes	selectivity
T768	905-908	CC	denotes	and
T769	909-924	RB	denotes	developmentally
T770	925-934	JJ	denotes	important
T771	944-950	NNS	denotes	bursts
T772	935-943	JJ	denotes	rhythmic
T773	950-951	.	denotes	.
T774	951-1086	sentence	denotes	Typically, Rb is thought to block division by repressing E2fs, but to promote differentiation by potentiating tissue-specific factors.
T775	952-961	RB	denotes	Typically
T776	969-976	VBN	denotes	thought
T777	961-963	,	denotes	,
T778	963-965	NN	denotes	Rb
T779	966-968	VBZ	denotes	is
T780	977-979	TO	denotes	to
T781	980-985	VB	denotes	block
T782	986-994	NN	denotes	division
T783	995-997	IN	denotes	by
T784	998-1008	VBG	denotes	repressing
T785	1009-1013	NNS	denotes	E2fs
T786	1013-1015	,	denotes	,
T787	1015-1018	CC	denotes	but
T788	1019-1021	TO	denotes	to
T789	1022-1029	VB	denotes	promote
T790	1030-1045	NN	denotes	differentiation
T791	1046-1048	IN	denotes	by
T792	1049-1061	VBG	denotes	potentiating
T793	1062-1068	NN	denotes	tissue
T794	1069-1077	JJ	denotes	specific
T795	1068-1069	HYPH	denotes	-
T796	1078-1085	NNS	denotes	factors
T797	1085-1086	.	denotes	.
T798	1086-1168	sentence	denotes	Remarkably, however, Rb promotes SAC differentiation by inhibiting E2f3 activity.
T799	1087-1097	RB	denotes	Remarkably
T800	1111-1119	VBZ	denotes	promotes
T801	1097-1099	,	denotes	,
T802	1099-1106	RB	denotes	however
T803	1106-1108	,	denotes	,
T804	1108-1110	NN	denotes	Rb
T805	1120-1123	NN	denotes	SAC
T806	1124-1139	NN	denotes	differentiation
T807	1140-1142	IN	denotes	by
T808	1143-1153	VBG	denotes	inhibiting
T809	1154-1158	NN	denotes	E2f3
T810	1159-1167	NN	denotes	activity
T811	1167-1168	.	denotes	.
T812	1168-1303	sentence	denotes	Two E2f3 isoforms exist, and we find both in the developing retina, although intriguingly they show distinct subcellular distribution.
T813	1169-1172	CD	denotes	Two
T814	1178-1186	NNS	denotes	isoforms
T815	1173-1177	NN	denotes	E2f3
T816	1187-1192	VBP	denotes	exist
T817	1192-1194	,	denotes	,
T818	1194-1197	CC	denotes	and
T819	1198-1200	PRP	denotes	we
T820	1201-1205	VBP	denotes	find
T821	1206-1210	DT	denotes	both
T822	1211-1213	IN	denotes	in
T823	1214-1217	DT	denotes	the
T824	1229-1235	NN	denotes	retina
T825	1218-1228	VBG	denotes	developing
T826	1235-1237	,	denotes	,
T827	1237-1245	IN	denotes	although
T828	1264-1268	VBP	denotes	show
T829	1246-1258	RB	denotes	intriguingly
T830	1259-1263	PRP	denotes	they
T831	1269-1277	JJ	denotes	distinct
T832	1290-1302	NN	denotes	distribution
T833	1278-1289	JJ	denotes	subcellular
T834	1302-1303	.	denotes	.
T835	1303-1363	sentence	denotes	E2f3b is thought to mediate Rb function in quiescent cells.
T836	1304-1309	NN	denotes	E2f3b
T837	1313-1320	VBN	denotes	thought
T838	1310-1312	VBZ	denotes	is
T839	1321-1323	TO	denotes	to
T840	1324-1331	VB	denotes	mediate
T841	1332-1334	NN	denotes	Rb
T842	1335-1343	NN	denotes	function
T843	1344-1346	IN	denotes	in
T844	1347-1356	JJ	denotes	quiescent
T845	1357-1362	NNS	denotes	cells
T846	1362-1363	.	denotes	.
T847	1363-1515	sentence	denotes	However, in what is to our knowledge the first work to dissect E2f isoform function in vivo we show that Rb promotes SAC differentiation through E2f3a.
T848	1364-1371	RB	denotes	However
T849	1459-1463	VBP	denotes	show
T850	1371-1373	,	denotes	,
T851	1373-1375	IN	denotes	in
T852	1376-1380	WP	denotes	what
T853	1381-1383	VBZ	denotes	is
T854	1384-1386	IN	denotes	to
T855	1387-1390	PRP$	denotes	our
T856	1391-1400	NN	denotes	knowledge
T857	1401-1404	DT	denotes	the
T858	1411-1415	NN	denotes	work
T859	1405-1410	JJ	denotes	first
T860	1416-1418	TO	denotes	to
T861	1419-1426	VB	denotes	dissect
T862	1427-1430	NN	denotes	E2f
T863	1439-1447	NN	denotes	function
T864	1431-1438	NN	denotes	isoform
T865	1448-1450	FW	denotes	in
T866	1451-1455	FW	denotes	vivo
T867	1456-1458	PRP	denotes	we
T868	1464-1468	IN	denotes	that
T869	1472-1480	VBZ	denotes	promotes
T870	1469-1471	NN	denotes	Rb
T871	1481-1484	NN	denotes	SAC
T872	1485-1500	NN	denotes	differentiation
T873	1501-1508	IN	denotes	through
T874	1509-1514	NN	denotes	E2f3a
T875	1514-1515	.	denotes	.
T876	1515-1702	sentence	denotes	These data reveal a mechanism through which Rb regulates neural differentiation directly, and, unexpectedly, it involves inhibition of E2f3a, not potentiation of tissue-specific factors.
T877	1516-1521	DT	denotes	These
T878	1522-1526	NNS	denotes	data
T879	1527-1533	VBP	denotes	reveal
T880	1534-1535	DT	denotes	a
T881	1536-1545	NN	denotes	mechanism
T882	1546-1553	IN	denotes	through
T883	1563-1572	VBZ	denotes	regulates
T884	1554-1559	WDT	denotes	which
T885	1560-1562	NN	denotes	Rb
T886	1573-1579	JJ	denotes	neural
T887	1580-1595	NN	denotes	differentiation
T888	1596-1604	RB	denotes	directly
T889	1604-1606	,	denotes	,
T890	1606-1609	CC	denotes	and
T891	1609-1611	,	denotes	,
T892	1611-1623	RB	denotes	unexpectedly
T893	1628-1636	VBZ	denotes	involves
T894	1623-1625	,	denotes	,
T895	1625-1627	PRP	denotes	it
T896	1637-1647	NN	denotes	inhibition
T897	1648-1650	IN	denotes	of
T898	1651-1656	NN	denotes	E2f3a
T899	1656-1658	,	denotes	,
T900	1658-1661	RB	denotes	not
T901	1662-1674	NN	denotes	potentiation
T902	1675-1677	IN	denotes	of
T903	1678-1684	NN	denotes	tissue
T904	1685-1693	JJ	denotes	specific
T905	1684-1685	HYPH	denotes	-
T906	1694-1701	NNS	denotes	factors
T907	1701-1702	.	denotes	.
T4273	6774-6776	,	denotes	,
T3864	3173-3176	DT	denotes	The
T3865	3177-3187	NN	denotes	simplicity
T3866	3202-3207	VBZ	denotes	makes
T3867	3188-3190	IN	denotes	of
T3868	3191-3194	DT	denotes	the
T3869	3195-3201	NN	denotes	retina
T3870	3208-3210	PRP	denotes	it
T3871	3220-3226	NN	denotes	tissue
T3872	3211-3213	DT	denotes	an
T3873	3214-3219	JJ	denotes	ideal
T3874	3227-3229	TO	denotes	to
T3875	3230-3235	VB	denotes	study
T3876	3236-3248	NN	denotes	neurogenesis
T3877	3248-3249	.	denotes	.
T3878	3249-3548	sentence	denotes	Its development proceeds through three overlapping steps starting with retinal progenitor cell (RPC) proliferation, followed by birth of post-mitotic retinal transition cells (RTCs, also referred to as precursors), and ending with terminal differentiation of seven major cell types (Figure 1A) [1].
T3879	3250-3253	PRP$	denotes	Its
T3880	3254-3265	NN	denotes	development
T3881	3266-3274	VBZ	denotes	proceeds
T3882	3275-3282	IN	denotes	through
T3883	3283-3288	CD	denotes	three
T3884	3301-3306	NNS	denotes	steps
T3885	3289-3300	VBG	denotes	overlapping
T3886	3307-3315	VBG	denotes	starting
T3887	3316-3320	IN	denotes	with
T3888	3321-3328	JJ	denotes	retinal
T3889	3340-3344	NN	denotes	cell
T3890	3329-3339	NN	denotes	progenitor
T3891	3351-3364	NN	denotes	proliferation
T3892	3345-3346	-LRB-	denotes	(
T3893	3346-3349	NN	denotes	RPC
T3894	3349-3350	-RRB-	denotes	)
T3895	3364-3366	,	denotes	,
T3896	3366-3374	VBN	denotes	followed
T3897	3375-3377	IN	denotes	by
T3898	3378-3383	NN	denotes	birth
T3899	3384-3386	IN	denotes	of
T3900	3387-3399	JJ	denotes	post-mitotic
T3901	3419-3424	NNS	denotes	cells
T3902	3400-3407	JJ	denotes	retinal
T3903	3408-3418	NN	denotes	transition
T3904	3425-3426	-LRB-	denotes	(
T3905	3426-3430	NNS	denotes	RTCs
T3906	3430-3432	,	denotes	,
T3907	3432-3436	RB	denotes	also
T3908	3437-3445	VBN	denotes	referred
T3909	3446-3448	IN	denotes	to
T3910	3449-3451	IN	denotes	as
T3911	3452-3462	NNS	denotes	precursors
T3912	3462-3463	-RRB-	denotes	)
T3913	3463-3465	,	denotes	,
T3914	3465-3468	CC	denotes	and
T3915	3469-3475	VBG	denotes	ending
T3916	3476-3480	IN	denotes	with
T3917	3481-3489	JJ	denotes	terminal
T3918	3490-3505	NN	denotes	differentiation
T3919	3506-3508	IN	denotes	of
T3920	3509-3514	CD	denotes	seven
T3921	3526-3531	NNS	denotes	types
T3922	3515-3520	JJ	denotes	major
T3923	3521-3525	NN	denotes	cell
T3924	3532-3533	-LRB-	denotes	(
T3925	3540-3542	NN	denotes	1A
T3926	3533-3539	NN	denotes	Figure
T3927	3542-3543	-RRB-	denotes	)
T3928	3544-3545	-LRB-	denotes	[
T3929	3545-3546	CD	denotes	1
T3930	3546-3547	-RRB-	denotes	]
T3931	3547-3548	.	denotes	.
T3932	3548-3665	sentence	denotes	RPCs are multipotent and exit the cell cycle to generate different RTCs at specific time periods in development [1].
T3933	3549-3553	NNS	denotes	RPCs
T3934	3554-3557	VBP	denotes	are
T3935	3558-3569	JJ	denotes	multipotent
T3936	3570-3573	CC	denotes	and
T3937	3574-3578	VBP	denotes	exit
T3938	3579-3582	DT	denotes	the
T3939	3588-3593	NN	denotes	cycle
T3940	3583-3587	NN	denotes	cell
T3941	3594-3596	TO	denotes	to
T3942	3597-3605	VB	denotes	generate
T3943	3606-3615	JJ	denotes	different
T3944	3616-3620	NNS	denotes	RTCs
T3945	3621-3623	IN	denotes	at
T3946	3624-3632	JJ	denotes	specific
T3947	3638-3645	NNS	denotes	periods
T3948	3633-3637	NN	denotes	time
T3949	3646-3648	IN	denotes	in
T3950	3649-3660	NN	denotes	development
T3951	3661-3662	-LRB-	denotes	[
T3952	3662-3663	CD	denotes	1
T3953	3663-3664	-RRB-	denotes	]
T3954	3664-3665	.	denotes	.
T3955	3665-3751	sentence	denotes	This process of RTC “birth” requires coupling of differentiation and cell cycle exit.
T3956	3666-3670	DT	denotes	This
T3957	3671-3678	NN	denotes	process
T3958	3694-3702	VBZ	denotes	requires
T3959	3679-3681	IN	denotes	of
T3960	3682-3685	NN	denotes	RTC
T3961	3687-3692	NN	denotes	birth
T3962	3686-3687	``	denotes	“
T3963	3692-3693	''	denotes	”
T3964	3703-3711	NN	denotes	coupling
T3965	3712-3714	IN	denotes	of
T3966	3715-3730	NN	denotes	differentiation
T3967	3731-3734	CC	denotes	and
T3968	3735-3739	NN	denotes	cell
T3969	3740-3745	NN	denotes	cycle
T3970	3746-3750	NN	denotes	exit
T3971	3750-3751	.	denotes	.
T3972	3751-3823	sentence	denotes	Once born, post-mitotic RTCs migrate and form different retinal layers.
T3973	3752-3756	IN	denotes	Once
T3974	3757-3761	VBN	denotes	born
T3975	3781-3788	VBP	denotes	migrate
T3976	3761-3763	,	denotes	,
T3977	3763-3775	JJ	denotes	post-mitotic
T3978	3776-3780	NNS	denotes	RTCs
T3979	3789-3792	CC	denotes	and
T3980	3793-3797	VBP	denotes	form
T3981	3798-3807	JJ	denotes	different
T3982	3816-3822	NNS	denotes	layers
T3983	3808-3815	JJ	denotes	retinal
T3984	3822-3823	.	denotes	.
T3985	3823-4085	sentence	denotes	Rods and cones make up the outer nuclear layer (ONL); horizontal, bipolar, and amacrine cells, as well as Müller glia cell bodies, reside in the inner nuclear layer (INL); and ganglion and displaced amacrine cells form the ganglion cell layer (GCL) (Figure 1A).
T3986	3824-3828	NNS	denotes	Rods
T3987	3839-3843	VBP	denotes	make
T3988	3829-3832	CC	denotes	and
T3989	3833-3838	NNS	denotes	cones
T3990	3844-3846	RP	denotes	up
T3991	3847-3850	DT	denotes	the
T3992	3865-3870	NN	denotes	layer
T3993	3851-3856	JJ	denotes	outer
T3994	3857-3864	JJ	denotes	nuclear
T3995	3871-3872	-LRB-	denotes	(
T3996	3872-3875	NN	denotes	ONL
T3997	3875-3876	-RRB-	denotes	)
T3998	3876-3877	:	denotes	;
T3999	3878-3888	JJ	denotes	horizontal
T4000	3912-3917	NNS	denotes	cells
T4001	3888-3890	,	denotes	,
T4002	3890-3897	JJ	denotes	bipolar
T4003	3897-3899	,	denotes	,
T4004	3899-3902	CC	denotes	and
T4005	3903-3911	JJ	denotes	amacrine
T4006	3955-3961	VBP	denotes	reside
T4007	3917-3919	,	denotes	,
T4008	3919-3921	RB	denotes	as
T4009	3927-3929	IN	denotes	as
T4010	3922-3926	RB	denotes	well
T4011	3930-3936	NN	denotes	Müller
T4012	3937-3941	NN	denotes	glia
T4013	3947-3953	NNS	denotes	bodies
T4014	3942-3946	NN	denotes	cell
T4057	4144-4145	-LRB-	denotes	(
T4058	4145-4148	NN	denotes	IPL
T4059	4148-4149	-RRB-	denotes	)
T4060	4156-4164	JJ	denotes	synaptic
T4061	4165-4176	NNS	denotes	connections
T4062	4177-4187	VBG	denotes	separating
T4063	4188-4191	DT	denotes	the
T4064	4196-4199	NN	denotes	INL
T4065	4192-4195	NN	denotes	ONL
T4066	4195-4196	HYPH	denotes	/
T4067	4200-4203	CC	denotes	and
T4068	4204-4207	NN	denotes	INL
T4069	4208-4211	NN	denotes	GCL
T4070	4207-4208	HYPH	denotes	/
T4071	4211-4213	,	denotes	,
T4072	4213-4225	RB	denotes	respectively
T4073	4225-4226	.	denotes	.
T4074	4226-4227	sentence	denotes
T4143	6124-6125	-RRB-	denotes	]
T4145	6126-6375	sentence	denotes	Rb controls the cell cycle by binding and inhibiting E2f transcription factors (E2fs) (Figure 1B), first defined as transcription factors that bind adenoviral E2 regulatory elements and subsequently shown to be critical cell cycle regulators [4,5].
T4146	6127-6129	NN	denotes	Rb
T4147	6130-6138	VBZ	denotes	controls
T4148	6139-6142	DT	denotes	the
T4149	6148-6153	NN	denotes	cycle
T4150	6143-6147	NN	denotes	cell
T4151	6154-6156	IN	denotes	by
T4152	6157-6164	VBG	denotes	binding
T4153	6165-6168	CC	denotes	and
T4154	6169-6179	VBG	denotes	inhibiting
T4155	6180-6183	NN	denotes	E2f
T4156	6198-6205	NNS	denotes	factors
T4157	6184-6197	NN	denotes	transcription
T4158	6206-6207	-LRB-	denotes	(
T4159	6207-6211	NNS	denotes	E2fs
T4160	6211-6212	-RRB-	denotes	)
T4161	6213-6214	-LRB-	denotes	(
T4162	6221-6223	NN	denotes	1B
T4163	6214-6220	NN	denotes	Figure
T4164	6223-6224	-RRB-	denotes	)
T4165	6224-6226	,	denotes	,
T4166	6226-6231	RB	denotes	first
T4167	6232-6239	VBN	denotes	defined
T4168	6240-6242	IN	denotes	as
T4169	6243-6256	NN	denotes	transcription
T4170	6257-6264	NNS	denotes	factors
T4171	6265-6269	WDT	denotes	that
T4172	6270-6274	VBP	denotes	bind
T4173	6275-6285	JJ	denotes	adenoviral
T4174	6300-6308	NNS	denotes	elements
T4175	6286-6288	NN	denotes	E2
T4176	6289-6299	JJ	denotes	regulatory
T4177	6309-6312	CC	denotes	and
T4178	6313-6325	RB	denotes	subsequently
T4179	6326-6331	VBN	denotes	shown
T4180	6332-6334	TO	denotes	to
T4181	6335-6337	VB	denotes	be
T4182	6338-6346	JJ	denotes	critical
T4183	6358-6368	NNS	denotes	regulators
T4184	6347-6351	NN	denotes	cell
T4185	6352-6357	NN	denotes	cycle
T4186	6369-6370	-LRB-	denotes	[
T4187	6372-6373	CD	denotes	5
T4188	6370-6371	CD	denotes	4
T4189	6371-6372	,	denotes	,
T4190	6373-6374	-RRB-	denotes	]
T4191	6374-6375	.	denotes	.
T4192	6375-6450	sentence	denotes	E2fs bind to DNA as heterodimers with proteins of the related Tfdp family.
T4193	6376-6380	NNS	denotes	E2fs
T4194	6381-6385	VBP	denotes	bind
T4195	6386-6388	IN	denotes	to
T4196	6389-6392	NN	denotes	DNA
T4197	6393-6395	IN	denotes	as
T4198	6396-6408	NNS	denotes	heterodimers
T4199	6409-6413	IN	denotes	with
T4200	6414-6422	NN	denotes	proteins
T4201	6423-6425	IN	denotes	of
T4202	6426-6429	DT	denotes	the
T4203	6443-6449	NN	denotes	family
T4204	6430-6437	VBN	denotes	related
T4205	6438-6442	NN	denotes	Tfdp
T4206	6449-6450	.	denotes	.
T4207	6450-6537	sentence	denotes	E2f1, E2f2, and E2f3a are “activating E2fs” that are required for fibroblast division.
T4208	6451-6455	NN	denotes	E2f1
T4209	6473-6476	VBP	denotes	are
T4210	6455-6457	,	denotes	,
T4211	6457-6461	NN	denotes	E2f2
T4212	6461-6463	,	denotes	,
T4213	6463-6466	CC	denotes	and
T4214	6467-6472	NN	denotes	E2f3a
T4215	6477-6478	``	denotes	“
T4216	6478-6488	NN	denotes	activating
T4217	6489-6493	NNS	denotes	E2fs
T4218	6493-6494	''	denotes	”
T4219	6495-6499	WDT	denotes	that
T4220	6504-6512	VBN	denotes	required
T4221	6500-6503	VBP	denotes	are
T4222	6513-6516	IN	denotes	for
T4223	6517-6527	NN	denotes	fibroblast
T4224	6528-6536	NN	denotes	division
T4225	6536-6537	.	denotes	.
T4226	6537-6664	sentence	denotes	They are strong transcriptional activators that can drive G0 fibroblasts into cycle, and are inhibited when bound to Rb [4,5].
T4227	6538-6542	PRP	denotes	They
T4228	6543-6546	VBP	denotes	are
T4229	6547-6553	JJ	denotes	strong
T4230	6570-6580	NNS	denotes	activators
T4231	6554-6569	JJ	denotes	transcriptional
T4232	6581-6585	WDT	denotes	that
T4233	6590-6595	VB	denotes	drive
T4234	6586-6589	MD	denotes	can
T4235	6596-6598	NN	denotes	G0
T4236	6599-6610	NNS	denotes	fibroblasts
T4237	6611-6615	IN	denotes	into
T4238	6616-6621	NN	denotes	cycle
T4239	6621-6623	,	denotes	,
T4240	6623-6626	CC	denotes	and
T4241	6627-6630	VBP	denotes	are
T4242	6631-6640	VBN	denotes	inhibited
T4243	6641-6645	WRB	denotes	when
T4244	6646-6651	VBN	denotes	bound
T4245	6652-6654	IN	denotes	to
T4246	6655-6657	NN	denotes	Rb
T4247	6658-6659	-LRB-	denotes	[
T4248	6661-6662	CD	denotes	5
T4249	6659-6660	CD	denotes	4
T4250	6660-6661	,	denotes	,
T4251	6662-6663	-RRB-	denotes	]
T4252	6663-6664	.	denotes	.
T4253	6664-6857	sentence	denotes	Ectopic division in Rb KO embryos can be rescued to various extents in different tissues by knocking out E2f1, E2f2, or E2f3 [6–9], but which member(s) drive division in Rb KO RTCs is unknown.
T4254	6665-6672	JJ	denotes	Ectopic
T4255	6673-6681	NN	denotes	division
T4256	6706-6713	VBN	denotes	rescued
T4257	6682-6684	IN	denotes	in
T4258	6685-6687	NN	denotes	Rb
T4259	6688-6690	NN	denotes	KO
T4260	6691-6698	NNS	denotes	embryos
T4261	6699-6702	MD	denotes	can
T4262	6703-6705	VB	denotes	be
T4263	6714-6716	IN	denotes	to
T4264	6717-6724	JJ	denotes	various
T4265	6725-6732	NNS	denotes	extents
T4266	6733-6735	IN	denotes	in
T4267	6736-6745	JJ	denotes	different
T4268	6746-6753	NNS	denotes	tissues
T4269	6754-6756	IN	denotes	by
T4270	6757-6765	VBG	denotes	knocking
T4271	6766-6769	RP	denotes	out
T4274	6776-6780	NN	denotes	E2f2
T4275	6780-6782	,	denotes	,
T4276	6782-6784	CC	denotes	or
T4277	6785-6789	NN	denotes	E2f3
T4278	6790-6791	-LRB-	denotes	[
T4279	6791-6792	CD	denotes	6
T4280	6792-6793	SYM	denotes	–
T4281	6793-6794	CD	denotes	9
T4282	6794-6795	-RRB-	denotes	]
T4283	6795-6797	,	denotes	,
T4284	6797-6800	CC	denotes	but
T4285	6801-6806	WDT	denotes	which
T4286	6807-6813	NN	denotes	member
T4287	6817-6822	VBP	denotes	drive
T4288	6813-6814	-LRB-	denotes	(
T4289	6814-6815	AFX	denotes	s
T4290	6815-6816	-RRB-	denotes	)
T4291	6846-6848	VBZ	denotes	is
T4292	6823-6831	NN	denotes	division
T4293	6832-6834	IN	denotes	in
T4294	6835-6837	NN	denotes	Rb
T4295	6838-6840	NN	denotes	KO
T4296	6841-6845	NNS	denotes	RTCs
T4297	6849-6856	JJ	denotes	unknown
T4298	6856-6857	.	denotes	.
T4299	6857-7065	sentence	denotes	Other members of the family, such as E2f4 and E2f5, are known as “repressive E2fs” because they are weak activators and appear to be primarily involved in gene silencing in quiescent or differentiated cells.
T4300	6858-6863	JJ	denotes	Other
T4301	6864-6871	NNS	denotes	members
T4302	6914-6919	VBN	denotes	known
T4303	6872-6874	IN	denotes	of
T4304	6875-6878	DT	denotes	the
T4305	6879-6885	NN	denotes	family
T4306	6885-6887	,	denotes	,
T4307	6887-6891	JJ	denotes	such
T4308	6892-6894	IN	denotes	as
T4309	6895-6899	NN	denotes	E2f4
T4310	6900-6903	CC	denotes	and
T4311	6904-6908	NN	denotes	E2f5
T4312	6908-6910	,	denotes	,
T4313	6910-6913	VBP	denotes	are
T4314	6920-6922	IN	denotes	as
T4315	6923-6924	``	denotes	“
T4316	6935-6939	NNS	denotes	E2fs
T4317	6924-6934	JJ	denotes	repressive
T4318	6939-6940	''	denotes	”
T4319	6941-6948	IN	denotes	because
T4320	6954-6957	VBP	denotes	are
T4321	6949-6953	PRP	denotes	they
T4322	6958-6962	JJ	denotes	weak
T4323	6963-6973	NNS	denotes	activators
T4324	6974-6977	CC	denotes	and
T4325	6978-6984	VBP	denotes	appear
T4326	6985-6987	TO	denotes	to
T4327	7001-7009	VBN	denotes	involved
T4328	6988-6990	VB	denotes	be
T4329	6991-7000	RB	denotes	primarily
T4330	7010-7012	IN	denotes	in
T4331	7013-7017	NN	denotes	gene
T4332	7018-7027	NN	denotes	silencing
T4333	7028-7030	IN	denotes	in
T4334	7031-7040	JJ	denotes	quiescent
T4335	7059-7064	NNS	denotes	cells
T4336	7041-7043	CC	denotes	or
T4337	7044-7058	VBN	denotes	differentiated
T4338	7064-7065	.	denotes	.
T4339	7065-7141	sentence	denotes	Activating E2fs may also promote apoptosis in the Rb KO retina (Figure 1B).
T4340	7066-7076	VBG	denotes	Activating
T4341	7091-7098	VB	denotes	promote
T4342	7077-7081	NNS	denotes	E2fs
T4343	7082-7085	MD	denotes	may
T4344	7086-7090	RB	denotes	also
T4345	7099-7108	NN	denotes	apoptosis
T4346	7109-7111	IN	denotes	in
T4347	7112-7115	DT	denotes	the
T4348	7122-7128	NN	denotes	retina
T4349	7116-7118	NN	denotes	Rb
T4350	7119-7121	NN	denotes	KO
T4351	7129-7130	-LRB-	denotes	(
T4352	7137-7139	NN	denotes	1B
T4353	7130-7136	NN	denotes	Figure
T4354	7139-7140	-RRB-	denotes	)
T4355	7140-7141	.	denotes	.
T4356	7141-7226	sentence	denotes	Originally, E2f1 was considered the primary pro-apoptotic member of the family [10].
T4357	7142-7152	RB	denotes	Originally
T4358	7163-7173	VBN	denotes	considered
T4359	7152-7154	,	denotes	,
T4360	7154-7158	NN	denotes	E2f1
T4361	7159-7162	VBD	denotes	was
T4362	7174-7177	DT	denotes	the
T4363	7200-7206	NN	denotes	member
T4364	7178-7185	JJ	denotes	primary
T4365	7186-7199	JJ	denotes	pro-apoptotic
T4366	7207-7209	IN	denotes	of
T4367	7210-7213	DT	denotes	the
T4368	7214-7220	NN	denotes	family
T4369	7221-7222	-LRB-	denotes	[
T4370	7222-7224	CD	denotes	10
T4371	7224-7225	-RRB-	denotes	]
T4372	7225-7226	.	denotes	.
T4373	7226-7403	sentence	denotes	However, this view was reevaluated when it was shown that either E2f1 or E2f3 deletion rescues apoptosis in the developing central nervous system (CNS) of Rb KO embryos [6,11].
T4374	7227-7234	RB	denotes	However
T4375	7250-7261	VBN	denotes	reevaluated
T4376	7234-7236	,	denotes	,
T4377	7236-7240	DT	denotes	this
T4378	7241-7245	NN	denotes	view
T4379	7246-7249	VBD	denotes	was
T4380	7262-7266	WRB	denotes	when
T4381	7274-7279	VBN	denotes	shown
T4382	7267-7269	PRP	denotes	it
T4383	7270-7273	VBD	denotes	was
T4384	7280-7284	IN	denotes	that
T4385	7314-7321	VBZ	denotes	rescues
T4386	7285-7291	CC	denotes	either
T4387	7292-7296	NN	denotes	E2f1
T4388	7305-7313	NN	denotes	deletion
T4389	7297-7299	CC	denotes	or
T4390	7300-7304	NN	denotes	E2f3
T4391	7322-7331	NN	denotes	apoptosis
T4392	7332-7334	IN	denotes	in
T4393	7335-7338	DT	denotes	the
T4394	7366-7372	NN	denotes	system
T4395	7339-7349	VBG	denotes	developing
T4396	7350-7357	JJ	denotes	central
T4397	7358-7365	JJ	denotes	nervous
T4398	7373-7374	-LRB-	denotes	(
T4399	7374-7377	NN	denotes	CNS
T4400	7377-7378	-RRB-	denotes	)
T4401	7379-7381	IN	denotes	of
T4402	7382-7384	NN	denotes	Rb
T4403	7385-7387	NN	denotes	KO
T4404	7388-7395	NNS	denotes	embryos
T4405	7396-7397	-LRB-	denotes	[
T4406	7399-7401	CD	denotes	11
T4407	7397-7398	CD	denotes	6
T4408	7398-7399	,	denotes	,
T4409	7401-7402	-RRB-	denotes	]
T4410	7402-7403	.	denotes	.
T4411	7403-7517	sentence	denotes	Subsequently, CNS apoptosis was shown to be an indirect result of placental defects and probable hypoxia [12–14].
T4412	7404-7416	RB	denotes	Subsequently
T4413	7436-7441	VBN	denotes	shown
T4414	7416-7418	,	denotes	,
T4415	7418-7421	NN	denotes	CNS
T4416	7422-7431	NN	denotes	apoptosis
T4417	7432-7435	VBD	denotes	was
T4418	7442-7444	TO	denotes	to
T4419	7445-7447	VB	denotes	be
T4420	7448-7450	DT	denotes	an
T4421	7460-7466	NN	denotes	result
T4422	7451-7459	JJ	denotes	indirect
T4423	7467-7469	IN	denotes	of
T4424	7470-7479	JJ	denotes	placental
T4425	7480-7487	NNS	denotes	defects
T4426	7488-7491	CC	denotes	and
T4427	7492-7500	JJ	denotes	probable
T4428	7501-7508	NN	denotes	hypoxia
T4429	7509-7510	-LRB-	denotes	[
T4430	7510-7512	CD	denotes	12
T4431	7512-7513	SYM	denotes	–
T4432	7513-7515	CD	denotes	14
T4433	7515-7516	-RRB-	denotes	]
T4434	7516-7517	.	denotes	.
T4435	7517-7609	sentence	denotes	Indeed, E2f3-induced apoptosis in fibroblasts has recently been shown to require E2f1 [15].
T4436	7518-7524	RB	denotes	Indeed
T4437	7582-7587	VBN	denotes	shown
T4438	7524-7526	,	denotes	,
T4439	7526-7530	NN	denotes	E2f3
T4440	7531-7538	VBN	denotes	induced
T4441	7530-7531	HYPH	denotes	-
T4442	7539-7548	NN	denotes	apoptosis
T4443	7549-7551	IN	denotes	in
T4444	7552-7563	NNS	denotes	fibroblasts
T4445	7564-7567	VBZ	denotes	has
T4446	7568-7576	RB	denotes	recently
T4447	7577-7581	VBN	denotes	been
T4448	7588-7590	TO	denotes	to
T4449	7591-7598	VB	denotes	require
T4450	7599-7603	NN	denotes	E2f1
T4451	7604-7605	-LRB-	denotes	[
T4452	7605-7607	CD	denotes	15
T4453	7607-7608	-RRB-	denotes	]
T4454	7608-7609	.	denotes	.
T4455	7609-7698	sentence	denotes	Thus, it is controversial whether E2f3 is required for apoptosis of any Rb KO cell type.
T4456	7610-7614	RB	denotes	Thus
T4457	7619-7621	VBZ	denotes	is
T4458	7614-7616	,	denotes	,
T4459	7616-7618	PRP	denotes	it
T4460	7622-7635	JJ	denotes	controversial
T4461	7636-7643	IN	denotes	whether
T4462	7652-7660	VBN	denotes	required
T4463	7644-7648	NN	denotes	E2f3
T4464	7649-7651	VBZ	denotes	is
T4465	7661-7664	IN	denotes	for
T4466	7665-7674	NN	denotes	apoptosis
T4467	7675-7677	IN	denotes	of
T4468	7678-7681	DT	denotes	any
T4469	7693-7697	NN	denotes	type
T4470	7682-7684	NN	denotes	Rb
T4471	7685-7687	NN	denotes	KO
T4472	7688-7692	NN	denotes	cell
T4473	7697-7698	.	denotes	.
T4474	7698-7892	sentence	denotes	Determining which activating E2fs promote death in distinct Rb KO tissues requires conditional rather than germ line models of Rb deletion to avoid secondary indirect effects (such as hypoxia).
T4475	7699-7710	VBG	denotes	Determining
T4476	7773-7781	VBZ	denotes	requires
T4477	7711-7716	WDT	denotes	which
T4478	7728-7732	NNS	denotes	E2fs
T4479	7717-7727	VBG	denotes	activating
T4480	7733-7740	VBP	denotes	promote
T4481	7741-7746	NN	denotes	death
T4482	7747-7749	IN	denotes	in
T4483	7750-7758	JJ	denotes	distinct
T4484	7765-7772	NNS	denotes	tissues
T4485	7759-7761	NN	denotes	Rb
T4486	7762-7764	NN	denotes	KO
T4487	7782-7793	JJ	denotes	conditional
T4488	7816-7822	NNS	denotes	models
T4489	7794-7800	RB	denotes	rather
T4490	7801-7805	IN	denotes	than
T4491	7806-7810	NN	denotes	germ
T4492	7811-7815	NN	denotes	line
T4493	7823-7825	IN	denotes	of
T4494	7826-7828	NN	denotes	Rb
T4495	7829-7837	NN	denotes	deletion
T4496	7838-7840	TO	denotes	to
T4497	7841-7846	VB	denotes	avoid
T4498	7847-7856	JJ	denotes	secondary
T4499	7866-7873	NNS	denotes	effects
T4500	7857-7865	JJ	denotes	indirect
T4501	7874-7875	-LRB-	denotes	(
T4502	7875-7879	JJ	denotes	such
T4503	7880-7882	IN	denotes	as
T4504	7883-7890	NN	denotes	hypoxia
T4505	7890-7891	-RRB-	denotes	)
T4506	7891-7892	.	denotes	.
T4507	7892-7943	sentence	denotes	E2f family diversity is expanded by E2f3 isoforms.
T4508	7893-7896	NN	denotes	E2f
T4509	7904-7913	NN	denotes	diversity
T4510	7897-7903	NN	denotes	family
T4511	7917-7925	VBN	denotes	expanded
T4512	7914-7916	VBZ	denotes	is
T4513	7926-7928	IN	denotes	by
T4514	7929-7933	NN	denotes	E2f3
T4515	7934-7942	NNS	denotes	isoforms
T4516	7942-7943	.	denotes	.
T4517	7943-8051	sentence	denotes	Alternative promoters generate two forms (a and b) that are identical except for distinct first exons [16].
T4518	7944-7955	JJ	denotes	Alternative
T4519	7956-7965	NNS	denotes	promoters
T4520	7966-7974	VBP	denotes	generate
T4521	7975-7978	CD	denotes	two
T4522	7979-7984	NNS	denotes	forms
T4523	7985-7986	-LRB-	denotes	(
T4524	7986-7987	NN	denotes	a
T4525	7988-7991	CC	denotes	and
T4526	7992-7993	NN	denotes	b
T4527	7993-7994	-RRB-	denotes	)
T4528	7995-7999	WDT	denotes	that
T4529	8000-8003	VBP	denotes	are
T4530	8004-8013	JJ	denotes	identical
T4531	8014-8020	IN	denotes	except
T4532	8021-8024	IN	denotes	for
T4533	8025-8033	JJ	denotes	distinct
T4534	8040-8045	NNS	denotes	exons
T4535	8034-8039	JJ	denotes	first
T4536	8046-8047	-LRB-	denotes	[
T4537	8047-8049	CD	denotes	16
T4538	8049-8050	-RRB-	denotes	]
T4539	8050-8051	.	denotes	.
T4540	8051-8191	sentence	denotes	E2f3a is a strong activator, and, like other activating E2fs, its expression is induced when quiescent cells are stimulated to divide [16].
T4541	8052-8057	NN	denotes	E2f3a
T4542	8058-8060	VBZ	denotes	is
T4543	8061-8062	DT	denotes	a
T4544	8070-8079	NN	denotes	activator
T4545	8063-8069	JJ	denotes	strong
T4546	8079-8081	,	denotes	,
T4547	8081-8084	CC	denotes	and
T4548	8084-8086	,	denotes	,
T4549	8086-8090	IN	denotes	like
T4550	8132-8139	VBN	denotes	induced
T4551	8091-8096	JJ	denotes	other
T4552	8108-8112	NNS	denotes	E2fs
T4553	8097-8107	VBG	denotes	activating
T4554	8112-8114	,	denotes	,
T4555	8114-8117	PRP$	denotes	its
T4556	8118-8128	NN	denotes	expression
T4557	8129-8131	VBZ	denotes	is
T4558	8140-8144	WRB	denotes	when
T4559	8165-8175	VBN	denotes	stimulated
T4560	8145-8154	JJ	denotes	quiescent
T4561	8155-8160	NNS	denotes	cells
T4562	8161-8164	VBP	denotes	are
T4563	8176-8178	TO	denotes	to
T4564	8179-8185	VB	denotes	divide
T4565	8186-8187	-LRB-	denotes	[
T4566	8187-8189	CD	denotes	16
T4567	8189-8190	-RRB-	denotes	]
T4568	8190-8191	.	denotes	.
T4569	8191-8379	sentence	denotes	E2f3b, like repressive E2fs, is present in both quiescent and dividing cells, and in quiescent fibroblasts it associates primarily with Rb, suggesting that it mediates repression [16–18].
T4570	8192-8197	NN	denotes	E2f3b
T4571	8221-8223	VBZ	denotes	is
T4572	8197-8199	,	denotes	,
T4573	8199-8203	IN	denotes	like
T4574	8204-8214	JJ	denotes	repressive
T4575	8215-8219	NNS	denotes	E2fs
T4576	8219-8221	,	denotes	,
T4577	8224-8231	JJ	denotes	present
T4578	8232-8234	IN	denotes	in
T4579	8235-8239	CC	denotes	both
T4580	8240-8249	JJ	denotes	quiescent
T4581	8263-8268	NNS	denotes	cells
T4583	8254-8262	VBG	denotes	dividing
T4584	8268-8270	,	denotes	,
T4585	8270-8273	CC	denotes	and
T4586	8274-8276	IN	denotes	in
T4587	8302-8312	VBZ	denotes	associates
T4588	8277-8286	JJ	denotes	quiescent
T4589	8287-8298	NNS	denotes	fibroblasts
T4590	8299-8301	PRP	denotes	it
T4591	8313-8322	RB	denotes	primarily
T4592	8323-8327	IN	denotes	with
T4593	8328-8330	NN	denotes	Rb
T4594	8330-8332	,	denotes	,
T4595	8332-8342	VBG	denotes	suggesting
T4596	8343-8347	IN	denotes	that
T4597	8351-8359	VBZ	denotes	mediates
T4598	8348-8350	PRP	denotes	it
T4599	8360-8370	NN	denotes	repression
T4600	8371-8372	-LRB-	denotes	[
T4601	8372-8374	CD	denotes	16
T4602	8374-8375	SYM	denotes	–
T4603	8375-8377	CD	denotes	18
T4604	8377-8378	-RRB-	denotes	]
T4605	8378-8379	.	denotes	.
T4606	8379-8465	sentence	denotes	Indeed, silencing the Cdkn2d (p19Arf) locus in unstressed cells relies on E2f3b [19].
T4607	8380-8386	RB	denotes	Indeed
T4608	8444-8450	VBZ	denotes	relies
T4609	8386-8388	,	denotes	,
T4610	8388-8397	VBG	denotes	silencing
T4611	8398-8401	DT	denotes	the
T4612	8418-8423	NN	denotes	locus
T4613	8402-8408	NN	denotes	Cdkn2d
T4614	8409-8410	-LRB-	denotes	(
T4615	8410-8416	NN	denotes	p19Arf
T4616	8416-8417	-RRB-	denotes	)
T4617	8424-8426	IN	denotes	in
T4618	8427-8437	JJ	denotes	unstressed
T4619	8438-8443	NNS	denotes	cells
T4620	8451-8453	IN	denotes	on
T4621	8454-8459	NN	denotes	E2f3b
T4622	8460-8461	-LRB-	denotes	[
T4623	8461-8463	CD	denotes	19
T4624	8463-8464	-RRB-	denotes	]
T4625	8464-8465	.	denotes	.
T4626	8465-8578	sentence	denotes	Other E2fs may also exist in isoforms since at least two mRNA species have been detected for E2f1 and E2f2 [16].
T4627	8466-8471	JJ	denotes	Other
T4628	8472-8476	NNS	denotes	E2fs
T4629	8486-8491	VB	denotes	exist
T4630	8477-8480	MD	denotes	may
T4631	8481-8485	RB	denotes	also
T4632	8492-8494	IN	denotes	in
T4633	8495-8503	NNS	denotes	isoforms
T4634	8504-8509	IN	denotes	since
T4635	8546-8554	VBN	denotes	detected
T4636	8510-8512	RB	denotes	at
T4637	8519-8522	CD	denotes	two
T4638	8513-8518	RBS	denotes	least
T4639	8523-8527	NN	denotes	mRNA
T4640	8528-8535	NNS	denotes	species
T4641	8536-8540	VBP	denotes	have
T4642	8541-8545	VBN	denotes	been
T4643	8555-8558	IN	denotes	for
T4644	8559-8563	NN	denotes	E2f1
T4645	8564-8567	CC	denotes	and
T4646	8568-8572	NN	denotes	E2f2
T4647	8573-8574	-LRB-	denotes	[
T4648	8574-8576	CD	denotes	16
T4649	8576-8577	-RRB-	denotes	]
T4650	8577-8578	.	denotes	.
T4651	8578-8625	sentence	denotes	The roles of E2f isoforms in vivo are unknown.
T4652	8579-8582	DT	denotes	The
T4653	8583-8588	NNS	denotes	roles
T4654	8613-8616	VBP	denotes	are
T4655	8589-8591	IN	denotes	of
T4656	8592-8595	NN	denotes	E2f
T4657	8596-8604	NNS	denotes	isoforms
T4658	8605-8607	FW	denotes	in
T4659	8608-8612	FW	denotes	vivo
T4660	8617-8624	JJ	denotes	unknown
T4661	8624-8625	.	denotes	.
T4662	8625-8678	sentence	denotes	E2fs are also regulated by subcellular localization.
T4663	8626-8630	NNS	denotes	E2fs
T4664	8640-8649	VBN	denotes	regulated
T4665	8631-8634	VBP	denotes	are
T4666	8635-8639	RB	denotes	also
T4667	8650-8652	IN	denotes	by
T4668	8653-8664	JJ	denotes	subcellular
T4669	8665-8677	NN	denotes	localization
T4670	8677-8678	.	denotes	.
T4671	8678-8798	sentence	denotes	Although this feature has been best characterized for repressive E2fs [20–22], it also affects activating E2fs [23–25].
T4672	8679-8687	IN	denotes	Although
T4673	8715-8728	VBN	denotes	characterized
T4674	8688-8692	DT	denotes	this
T4675	8693-8700	NN	denotes	feature
T4676	8701-8704	VBZ	denotes	has
T4677	8705-8709	VBN	denotes	been
T4678	8710-8714	RBS	denotes	best
T4679	8766-8773	VBZ	denotes	affects
T4680	8729-8732	IN	denotes	for
T4681	8733-8743	JJ	denotes	repressive
T4682	8744-8748	NNS	denotes	E2fs
T4683	8749-8750	-LRB-	denotes	[
T4684	8750-8752	CD	denotes	20
T4685	8752-8753	SYM	denotes	–
T4686	8753-8755	CD	denotes	22
T4687	8755-8756	-RRB-	denotes	]
T4688	8756-8758	,	denotes	,
T4689	8758-8760	PRP	denotes	it
T4690	8761-8765	RB	denotes	also
T4691	8774-8784	VBG	denotes	activating
T4692	8785-8789	NNS	denotes	E2fs
T4693	8790-8791	-LRB-	denotes	[
T4694	8791-8793	CD	denotes	23
T4695	8793-8794	SYM	denotes	–
T4696	8794-8796	CD	denotes	25
T4697	8796-8797	-RRB-	denotes	]
T4698	8797-8798	.	denotes	.
T4699	8798-8856	sentence	denotes	The distribution of E2f isoforms has never been assessed.
T4700	8799-8802	DT	denotes	The
T4701	8803-8815	NN	denotes	distribution
T4702	8847-8855	VBN	denotes	assessed
T4703	8816-8818	IN	denotes	of
T4704	8819-8822	NN	denotes	E2f
T4705	8823-8831	NNS	denotes	isoforms
T4706	8832-8835	VBZ	denotes	has
T4707	8836-8841	RB	denotes	never
T4708	8842-8846	VBN	denotes	been
T4709	8855-8856	.	denotes	.
T4710	8856-8945	sentence	denotes	It has been known for many years that Rb loss perturbs neuronal differentiation [26–29].
T4711	8857-8859	PRP	denotes	It
T4712	8869-8874	VBN	denotes	known
T4713	8860-8863	VBZ	denotes	has
T4714	8864-8868	VBN	denotes	been
T4715	8875-8878	IN	denotes	for
T4716	8879-8883	JJ	denotes	many
T4717	8884-8889	NNS	denotes	years
T4718	8890-8894	IN	denotes	that
T4719	8903-8911	VBZ	denotes	perturbs
T4720	8895-8897	NN	denotes	Rb
T4721	8898-8902	NN	denotes	loss
T4722	8912-8920	JJ	denotes	neuronal
T4723	8921-8936	NN	denotes	differentiation
T4724	8937-8938	-LRB-	denotes	[
T4725	8938-8940	CD	denotes	26
T4726	8940-8941	SYM	denotes	–
T4727	8941-8943	CD	denotes	29
T4728	8943-8944	-RRB-	denotes	]
T4729	8944-8945	.	denotes	.
T4730	8945-9095	sentence	denotes	However, prior work could not exclude the possibility that differentiation defects are simply an indirect consequence of abnormal division and death.
T4731	8946-8953	RB	denotes	However
T4732	8976-8983	VB	denotes	exclude
T4733	8953-8955	,	denotes	,
T4734	8955-8960	JJ	denotes	prior
T4735	8961-8965	NN	denotes	work
T4736	8966-8971	MD	denotes	could
T4737	8972-8975	RB	denotes	not
T4738	8984-8987	DT	denotes	the
T4739	8988-8999	NN	denotes	possibility
T4740	9000-9004	IN	denotes	that
T4741	9029-9032	VBP	denotes	are
T4742	9005-9020	NN	denotes	differentiation
T4743	9021-9028	NNS	denotes	defects
T4744	9033-9039	RB	denotes	simply
T4745	9040-9042	DT	denotes	an
T4746	9052-9063	NN	denotes	consequence
T4747	9043-9051	JJ	denotes	indirect
T4748	9064-9066	IN	denotes	of
T4749	9067-9075	JJ	denotes	abnormal
T4750	9076-9084	NN	denotes	division
T4751	9085-9088	CC	denotes	and
T4752	9089-9094	NN	denotes	death
T4753	9094-9095	.	denotes	.
T4754	9095-9204	sentence	denotes	If Rb does regulate differentiation directly it is unclear whether it does so in all or a subset of neurons.
T4755	9096-9098	IN	denotes	If
T4756	9107-9115	VB	denotes	regulate
T4757	9099-9101	NN	denotes	Rb
T4758	9102-9106	VBZ	denotes	does
T4759	9144-9146	VBZ	denotes	is
T4760	9116-9131	NN	denotes	differentiation
T4761	9132-9140	RB	denotes	directly
T4762	9141-9143	PRP	denotes	it
T4763	9147-9154	JJ	denotes	unclear
T4764	9155-9162	IN	denotes	whether
T4765	9166-9170	VBZ	denotes	does
T4766	9163-9165	PRP	denotes	it
T4767	9171-9173	RB	denotes	so
T4768	9174-9176	IN	denotes	in
T4769	9177-9180	DT	denotes	all
T4770	9181-9183	CC	denotes	or
T4771	9184-9185	DT	denotes	a
T4772	9186-9192	NN	denotes	subset
T4773	9196-9203	NNS	denotes	neurons
T4774	9193-9195	IN	denotes	of
T4775	9203-9204	.	denotes	.
T4776	9204-9251	sentence	denotes	Moreover, the mechanism has never been solved.
T4777	9205-9213	RB	denotes	Moreover
T4778	9244-9250	VBN	denotes	solved
T4779	9213-9215	,	denotes	,
T4780	9215-9218	DT	denotes	the
T4781	9219-9228	NN	denotes	mechanism
T4782	9229-9232	VBZ	denotes	has
T4783	9233-9238	RB	denotes	never
T4784	9239-9243	VBN	denotes	been
T4785	9250-9251	.	denotes	.
T4786	9251-9466	sentence	denotes	In other cell types where Rb may promote differentiation directly, such as muscle and bone, it seems to do so through E2f-independent means by potentiating tissue-specific transcription factors (Figure 1B) [30–33].
T4787	9252-9254	IN	denotes	In
T4788	9347-9352	VBZ	denotes	seems
T4789	9255-9260	JJ	denotes	other
T4790	9266-9271	NNS	denotes	types
T4791	9261-9265	NN	denotes	cell
T4792	9272-9277	WRB	denotes	where
T4793	9285-9292	VB	denotes	promote
T4794	9278-9280	NN	denotes	Rb
T4795	9281-9284	MD	denotes	may
T4796	9293-9308	NN	denotes	differentiation
T4797	9309-9317	RB	denotes	directly
T4798	9317-9319	,	denotes	,
T4799	9319-9323	JJ	denotes	such
T4800	9324-9326	IN	denotes	as
T4801	9327-9333	NN	denotes	muscle
T4802	9334-9337	CC	denotes	and
T4803	9338-9342	NN	denotes	bone
T4804	9342-9344	,	denotes	,
T4805	9344-9346	PRP	denotes	it
T4806	9353-9355	TO	denotes	to
T4807	9356-9358	VB	denotes	do
T4808	9359-9361	RB	denotes	so
T4809	9362-9369	IN	denotes	through
T4810	9370-9373	NN	denotes	E2f
T4811	9374-9385	JJ	denotes	independent
T4812	9373-9374	HYPH	denotes	-
T4813	9386-9391	NNS	denotes	means
T4814	9392-9394	IN	denotes	by
T4815	9395-9407	VBG	denotes	potentiating
T4816	9408-9414	NN	denotes	tissue
T4817	9415-9423	JJ	denotes	specific
T4818	9414-9415	HYPH	denotes	-
T4819	9438-9445	NNS	denotes	factors
T4820	9424-9437	NN	denotes	transcription
T4821	9446-9447	-LRB-	denotes	(
T4822	9454-9456	NN	denotes	1B
T4823	9447-9453	NN	denotes	Figure
T4824	9456-9457	-RRB-	denotes	)
T4825	9458-9459	-LRB-	denotes	[
T4826	9459-9461	CD	denotes	30
T4827	9461-9462	SYM	denotes	–
T4828	9462-9464	CD	denotes	33
T4829	9464-9465	-RRB-	denotes	]
T4830	9465-9466	.	denotes	.
T4831	9466-9635	sentence	denotes	In the retina, others have noted abnormally shaped Rb KO rods and have suggested Rb may directly promote their morphogenesis by activating retina-specific factors [29].
T4832	9467-9469	IN	denotes	In
T4833	9494-9499	VBN	denotes	noted
T4834	9470-9473	DT	denotes	the
T4835	9474-9480	NN	denotes	retina
T4836	9480-9482	,	denotes	,
T4837	9482-9488	NNS	denotes	others
T4838	9489-9493	VBP	denotes	have
T4839	9500-9510	RB	denotes	abnormally
T4840	9511-9517	VBN	denotes	shaped
T4841	9524-9528	NNS	denotes	rods
T4842	9518-9520	NN	denotes	Rb
T4843	9521-9523	NN	denotes	KO
T4844	9529-9532	CC	denotes	and
T4845	9533-9537	VBP	denotes	have
T4846	9538-9547	VBN	denotes	suggested
T4847	9548-9550	NN	denotes	Rb
T4848	9564-9571	VB	denotes	promote
T4849	9551-9554	MD	denotes	may
T4850	9555-9563	RB	denotes	directly
T4851	9572-9577	PRP$	denotes	their
T4852	9578-9591	NN	denotes	morphogenesis
T4853	9592-9594	IN	denotes	by
T4854	9595-9605	VBG	denotes	activating
T4855	9606-9612	NN	denotes	retina
T4856	9613-9621	JJ	denotes	specific
T4857	9612-9613	HYPH	denotes	-
T4858	9622-9629	NNS	denotes	factors
T4859	9630-9631	-LRB-	denotes	[
T4860	9631-9633	CD	denotes	29
T4861	9633-9634	-RRB-	denotes	]
T4862	9634-9635	.	denotes	.
T4863	9635-9766	sentence	denotes	However, differentiation defects in any Rb KO neuron could be an indirect effect of ectopic division and/or apoptosis (Figure 1B).
T4864	9636-9643	RB	denotes	However
T4865	9695-9697	VB	denotes	be
T4866	9643-9645	,	denotes	,
T4867	9645-9660	NN	denotes	differentiation
T4868	9661-9668	NNS	denotes	defects
T4869	9669-9671	IN	denotes	in
T4870	9672-9675	DT	denotes	any
T4871	9682-9688	NN	denotes	neuron
T4872	9676-9678	NN	denotes	Rb
T4873	9679-9681	NN	denotes	KO
T4874	9689-9694	MD	denotes	could
T4875	9698-9700	DT	denotes	an
T4876	9710-9716	NN	denotes	effect
T4877	9701-9709	JJ	denotes	indirect
T4878	9717-9719	IN	denotes	of
T4879	9720-9727	JJ	denotes	ectopic
T4880	9728-9736	NN	denotes	division
T4881	9737-9740	CC	denotes	and
T4882	9740-9741	HYPH	denotes	/
T4883	9741-9743	CC	denotes	or
T4884	9744-9753	NN	denotes	apoptosis
T4885	9754-9755	-LRB-	denotes	(
T4886	9762-9764	NN	denotes	1B
T4887	9755-9761	NN	denotes	Figure
T4888	9764-9765	-RRB-	denotes	)
T4889	9765-9766	.	denotes	.
T4890	9766-9878	sentence	denotes	Thus, it is critical to study differentiation of Rb KO cells in the absence of ectopic proliferation and death.
T4891	9767-9771	RB	denotes	Thus
T4892	9776-9778	VBZ	denotes	is
T4893	9771-9773	,	denotes	,
T4894	9773-9775	PRP	denotes	it
T4895	9779-9787	JJ	denotes	critical
T4896	9788-9790	TO	denotes	to
T4897	9791-9796	VB	denotes	study
T4898	9797-9812	NN	denotes	differentiation
T4899	9813-9815	IN	denotes	of
T4900	9816-9818	NN	denotes	Rb
T4901	9819-9821	NN	denotes	KO
T4902	9822-9827	NNS	denotes	cells
T4903	9828-9830	IN	denotes	in
T4904	9831-9834	DT	denotes	the
T4905	9835-9842	NN	denotes	absence
T4906	9843-9845	IN	denotes	of
T4907	9846-9853	JJ	denotes	ectopic
T4908	9854-9867	NN	denotes	proliferation
T4909	9868-9871	CC	denotes	and
T4910	9872-9877	NN	denotes	death
T4911	9877-9878	.	denotes	.
T4912	9878-9977	sentence	denotes	Here, we establish that Rb suppresses RTC division and death by inhibiting E2f1, not E2f2 or E2f3.
T4913	9879-9883	RB	denotes	Here
T4914	9888-9897	VBP	denotes	establish
T4915	9883-9885	,	denotes	,
T4916	9885-9887	PRP	denotes	we
T4917	9898-9902	IN	denotes	that
T4918	9906-9916	VBZ	denotes	suppresses
T4919	9903-9905	NN	denotes	Rb
T4920	9917-9920	NN	denotes	RTC
T4921	9921-9929	NN	denotes	division
T4922	9930-9933	CC	denotes	and
T4923	9934-9939	NN	denotes	death
T4924	9940-9942	IN	denotes	by
T4925	9943-9953	VBG	denotes	inhibiting
T4926	9954-9958	NN	denotes	E2f1
T4927	9958-9960	,	denotes	,
T4928	9960-9963	CC	denotes	not
T4929	9964-9968	NN	denotes	E2f2
T4930	9969-9971	CC	denotes	or
T4931	9972-9976	NN	denotes	E2f3
T4932	9976-9977	.	denotes	.
T4933	9977-10099	sentence	denotes	When these defects were rescued, most retinal neurons, including rods, survived, differentiated, and functioned normally.
T4934	9978-9982	WRB	denotes	When
T4935	10002-10009	VBN	denotes	rescued
T4936	9983-9988	DT	denotes	these
T4937	9989-9996	NNS	denotes	defects
T4938	9997-10001	VBD	denotes	were
T4939	10049-10057	VBD	denotes	survived
T4940	10009-10011	,	denotes	,
T4941	10011-10015	RBS	denotes	most
T4942	10024-10031	NNS	denotes	neurons
T4943	10016-10023	JJ	denotes	retinal
T4944	10031-10033	,	denotes	,
T4945	10033-10042	VBG	denotes	including
T4946	10043-10047	NNS	denotes	rods
T4947	10047-10049	,	denotes	,
T4948	10057-10059	,	denotes	,
T4949	10059-10073	VBD	denotes	differentiated
T4950	10073-10075	,	denotes	,
T4951	10075-10078	CC	denotes	and
T4952	10079-10089	VBD	denotes	functioned
T4953	10090-10098	RB	denotes	normally
T4954	10098-10099	.	denotes	.
T4955	10099-10189	sentence	denotes	Thus, unexpectedly, retina-specific differentiation factors function independently of Rb.
T4956	10100-10104	RB	denotes	Thus
T4957	10160-10168	VBP	denotes	function
T4958	10104-10106	,	denotes	,
T4959	10106-10118	RB	denotes	unexpectedly
T4960	10118-10120	,	denotes	,
T4961	10120-10126	NN	denotes	retina
T4962	10127-10135	JJ	denotes	specific
T4963	10126-10127	HYPH	denotes	-
T4964	10152-10159	NNS	denotes	factors
T4965	10136-10151	NN	denotes	differentiation
T4966	10169-10182	RB	denotes	independently
T4967	10183-10185	IN	denotes	of
T4968	10186-10188	NN	denotes	Rb
T4969	10188-10189	.	denotes	.
T4970	10189-10347	sentence	denotes	However, comprehensive assessment of the Rb/E2f1 double-null rescued retina revealed a differentiation defect in cholinergic starburst amacrine cells (SACs).
T4971	10190-10197	RB	denotes	However
T4972	10266-10274	VBD	denotes	revealed
T4973	10197-10199	,	denotes	,
T4974	10199-10212	JJ	denotes	comprehensive
T4975	10213-10223	NN	denotes	assessment
T4976	10224-10226	IN	denotes	of
T4977	10227-10230	DT	denotes	the
T4978	10259-10265	NN	denotes	retina
T4979	10231-10233	NN	denotes	Rb
T4980	10234-10238	NN	denotes	E2f1
T4981	10233-10234	HYPH	denotes	/
T4982	10246-10250	JJ	denotes	null
T4983	10239-10245	JJ	denotes	double
T4984	10245-10246	HYPH	denotes	-
T4985	10251-10258	VBN	denotes	rescued
T4986	10275-10276	DT	denotes	a
T4987	10293-10299	NN	denotes	defect
T4988	10277-10292	NN	denotes	differentiation
T4989	10300-10302	IN	denotes	in
T4990	10303-10314	JJ	denotes	cholinergic
T4991	10334-10339	NNS	denotes	cells
T4992	10315-10324	NN	denotes	starburst
T4993	10325-10333	JJ	denotes	amacrine
T4994	10340-10341	-LRB-	denotes	(
T4995	10341-10345	NNS	denotes	SACs
T4996	10345-10346	-RRB-	denotes	)
T4997	10346-10347	.	denotes	.
T4998	10347-10500	sentence	denotes	Recent breakthroughs have revealed that these interneurons are critical for direction selectivity and developmentally important rhythmic bursts [34–36].
T4999	10348-10354	JJ	denotes	Recent
T5000	10355-10368	NNS	denotes	breakthroughs
T5001	10374-10382	VBN	denotes	revealed
T5002	10369-10373	VBP	denotes	have
T5003	10383-10387	IN	denotes	that
T5004	10407-10410	VBP	denotes	are
T5005	10388-10393	DT	denotes	these
T5006	10394-10406	NNS	denotes	interneurons
T5007	10411-10419	JJ	denotes	critical
T5008	10420-10423	IN	denotes	for
T5009	10424-10433	NN	denotes	direction
T5010	10434-10445	NN	denotes	selectivity
T5011	10446-10449	CC	denotes	and
T5012	10450-10465	RB	denotes	developmentally
T5013	10466-10475	JJ	denotes	important
T5014	10485-10491	NNS	denotes	bursts
T5015	10476-10484	JJ	denotes	rhythmic
T5016	10492-10493	-LRB-	denotes	[
T5017	10493-10495	CD	denotes	34
T5018	10495-10496	SYM	denotes	–
T5019	10496-10498	CD	denotes	36
T5020	10498-10499	-RRB-	denotes	]
T5021	10499-10500	.	denotes	.
T5022	10500-10553	sentence	denotes	However, their differentiation is poorly understood.
T5023	10501-10508	RB	denotes	However
T5024	10542-10552	VBN	denotes	understood
T5025	10508-10510	,	denotes	,
T5026	10510-10515	PRP$	denotes	their
T5027	10516-10531	NN	denotes	differentiation
T5028	10532-10534	VBZ	denotes	is
T5029	10535-10541	RB	denotes	poorly
T5030	10552-10553	.	denotes	.
T5031	10553-10739	sentence	denotes	Contrary to the prevailing view that Rb promotes differentiation through E2f-independent tissue-specific transcription factors, we show that Rb facilitates SAC development through E2f3.
T5032	10554-10562	JJ	denotes	Contrary
T5033	10685-10689	VBP	denotes	show
T5034	10563-10565	IN	denotes	to
T5035	10566-10569	DT	denotes	the
T5036	10581-10585	NN	denotes	view
T5037	10570-10580	VBG	denotes	prevailing
T5038	10586-10590	IN	denotes	that
T5039	10594-10602	VBZ	denotes	promotes
T5040	10591-10593	NN	denotes	Rb
T5041	10603-10618	NN	denotes	differentiation
T5042	10619-10626	IN	denotes	through
T5043	10627-10630	NN	denotes	E2f
T5044	10631-10642	JJ	denotes	independent
T5045	10630-10631	HYPH	denotes	-
T5046	10673-10680	NNS	denotes	factors
T5047	10643-10649	NN	denotes	tissue
T5048	10650-10658	JJ	denotes	specific
T5049	10649-10650	HYPH	denotes	-
T5050	10659-10672	NN	denotes	transcription
T5051	10680-10682	,	denotes	,
T5052	10682-10684	PRP	denotes	we
T5053	10690-10694	IN	denotes	that
T5054	10698-10709	VBZ	denotes	facilitates
T5055	10695-10697	NN	denotes	Rb
T5056	10710-10713	NN	denotes	SAC
T5057	10714-10725	NN	denotes	development
T5058	10726-10733	IN	denotes	through
T5059	10734-10738	NN	denotes	E2f3
T5060	10738-10739	.	denotes	.
T5061	10739-10894	sentence	denotes	Defects in Rb null SACs correlated with specific E2f3 expression in these cells, and E2f3 expression was absent in neurons that differentiated without Rb.
T5062	10740-10747	NNS	denotes	Defects
T5063	10764-10774	VBD	denotes	correlated
T5064	10748-10750	IN	denotes	in
T5065	10751-10753	NN	denotes	Rb
T5066	10754-10758	JJ	denotes	null
T5067	10759-10763	NNS	denotes	SACs
T5068	10775-10779	IN	denotes	with
T5069	10780-10788	JJ	denotes	specific
T5070	10794-10804	NN	denotes	expression
T5071	10789-10793	NN	denotes	E2f3
T5072	10805-10807	IN	denotes	in
T5073	10808-10813	DT	denotes	these
T5074	10814-10819	NNS	denotes	cells
T5075	10819-10821	,	denotes	,
T5076	10821-10824	CC	denotes	and
T5077	10825-10829	NN	denotes	E2f3
T5078	10830-10840	NN	denotes	expression
T5079	10841-10844	VBD	denotes	was
T5080	10845-10851	JJ	denotes	absent
T5081	10852-10854	IN	denotes	in
T5082	10855-10862	NNS	denotes	neurons
T5083	10863-10867	WDT	denotes	that
T5084	10868-10882	VBD	denotes	differentiated
T5085	10883-10890	IN	denotes	without
T5086	10891-10893	NN	denotes	Rb
T5087	10893-10894	.	denotes	.
T5088	10894-11042	sentence	denotes	E2f3 is also present in a specific subset of other CNS neurons, implying that this may be a general mechanism by which Rb facilitates neurogenesis.
T5089	10895-10899	NN	denotes	E2f3
T5090	10900-10902	VBZ	denotes	is
T5091	10903-10907	RB	denotes	also
T5092	10908-10915	JJ	denotes	present
T5093	10916-10918	IN	denotes	in
T5094	10919-10920	DT	denotes	a
T5095	10930-10936	NN	denotes	subset
T5096	10921-10929	JJ	denotes	specific
T5097	10937-10939	IN	denotes	of
T5098	10940-10945	JJ	denotes	other
T5099	10950-10957	NNS	denotes	neurons
T5100	10946-10949	NN	denotes	CNS
T5101	10957-10959	,	denotes	,
T5102	10959-10967	VBG	denotes	implying
T5103	10968-10972	IN	denotes	that
T5104	10982-10984	VB	denotes	be
T5105	10973-10977	DT	denotes	this
T5106	10978-10981	MD	denotes	may
T5107	10985-10986	DT	denotes	a
T5108	10995-11004	NN	denotes	mechanism
T5109	10987-10994	JJ	denotes	general
T5110	11005-11007	IN	denotes	by
T5111	11017-11028	VBZ	denotes	facilitates
T5112	11008-11013	WDT	denotes	which
T5113	11014-11016	NN	denotes	Rb
T5114	11029-11041	NN	denotes	neurogenesis
T5115	11041-11042	.	denotes	.
T5116	11042-11163	sentence	denotes	To define the mechanism in even more detail, we determined which E2f3 isoform Rb targets to control SAC differentiation.
T5117	11043-11045	TO	denotes	To
T5118	11046-11052	VB	denotes	define
T5119	11091-11101	VBD	denotes	determined
T5120	11053-11056	DT	denotes	the
T5121	11057-11066	NN	denotes	mechanism
T5122	11067-11069	IN	denotes	in
T5123	11070-11074	RB	denotes	even
T5124	11080-11086	NN	denotes	detail
T5125	11075-11079	JJR	denotes	more
T5126	11086-11088	,	denotes	,
T5127	11088-11090	PRP	denotes	we
T5128	11102-11107	WDT	denotes	which
T5129	11113-11120	NN	denotes	isoform
T5130	11108-11112	NN	denotes	E2f3
T5131	11124-11131	VBZ	denotes	targets
T5132	11121-11123	NN	denotes	Rb
T5133	11132-11134	TO	denotes	to
T5134	11135-11142	VB	denotes	control
T5135	11143-11146	NN	denotes	SAC
T5136	11147-11162	NN	denotes	differentiation
T5137	11162-11163	.	denotes	.
T5138	11163-11308	sentence	denotes	E2f3b mediates Rb function in quiescent fibroblasts [19], yet no prior studies to our knowledge have dissected E2f3a or E2f3b functions in vivo.
T5139	11164-11169	NN	denotes	E2f3b
T5140	11170-11178	VBZ	denotes	mediates
T5141	11179-11181	NN	denotes	Rb
T5142	11182-11190	NN	denotes	function
T5143	11191-11193	IN	denotes	in
T5144	11194-11203	JJ	denotes	quiescent
T5145	11204-11215	NNS	denotes	fibroblasts
T5146	11216-11217	-LRB-	denotes	[
T5147	11217-11219	CD	denotes	19
T5148	11219-11220	-RRB-	denotes	]
T5149	11220-11222	,	denotes	,
T5150	11222-11225	CC	denotes	yet
T5151	11226-11228	DT	denotes	no
T5152	11235-11242	NNS	denotes	studies
T5153	11229-11234	JJ	denotes	prior
T5154	11265-11274	VBN	denotes	dissected
T5155	11243-11245	IN	denotes	to
T5156	11246-11249	PRP$	denotes	our
T5157	11250-11259	NN	denotes	knowledge
T5158	11260-11264	VBP	denotes	have
T5159	11275-11280	NN	denotes	E2f3a
T5160	11290-11299	NNS	denotes	functions
T5161	11281-11283	CC	denotes	or
T5162	11284-11289	NN	denotes	E2f3b
T5163	11300-11302	FW	denotes	in
T5164	11303-11307	FW	denotes	vivo
T5165	11307-11308	.	denotes	.
T5166	11308-11403	sentence	denotes	Using an isoform-specific null mouse we show that Rb drives SAC differentiation through E2f3a.
T5167	11309-11314	VBG	denotes	Using
T5168	11349-11353	VBP	denotes	show
T5169	11315-11317	DT	denotes	an
T5170	11340-11345	NN	denotes	mouse
T5171	11318-11325	NN	denotes	isoform
T5172	11326-11334	JJ	denotes	specific
T5173	11325-11326	HYPH	denotes	-
T5174	11335-11339	JJ	denotes	null
T5175	11346-11348	PRP	denotes	we
T5176	11354-11358	IN	denotes	that
T5177	11362-11368	VBZ	denotes	drives
T5178	11359-11361	NN	denotes	Rb
T5179	11369-11372	NN	denotes	SAC
T5180	11373-11388	NN	denotes	differentiation
T5181	11389-11396	IN	denotes	through
T5182	11397-11402	NN	denotes	E2f3a
T5183	11402-11403	.	denotes	.
T5184	11403-11620	sentence	denotes	Thus, independent of E2f1-mediated effects on division and death, Rb does regulate neuronal differentiation, but only in specific neurons and, unexpectedly, through E2f3a, not tissue-specific differentiation factors.
T5185	11404-11408	RB	denotes	Thus
T5186	11478-11486	VB	denotes	regulate
T5187	11408-11410	,	denotes	,
T5188	11410-11421	JJ	denotes	independent
T5189	11422-11424	IN	denotes	of
T5190	11425-11429	NN	denotes	E2f1
T5191	11430-11438	VBN	denotes	mediated
T5192	11429-11430	HYPH	denotes	-
T5193	11439-11446	NNS	denotes	effects
T5194	11447-11449	IN	denotes	on
T5195	11450-11458	NN	denotes	division
T5196	11459-11462	CC	denotes	and
T5197	11463-11468	NN	denotes	death
T5198	11468-11470	,	denotes	,
T5199	11470-11472	NN	denotes	Rb
T5200	11473-11477	VBZ	denotes	does
T5201	11487-11495	JJ	denotes	neuronal
T5202	11496-11511	NN	denotes	differentiation
T5203	11511-11513	,	denotes	,
T5204	11513-11516	IN	denotes	but
T5205	11522-11524	IN	denotes	in
T5206	11517-11521	RB	denotes	only
T5207	11525-11533	JJ	denotes	specific
T5208	11534-11541	NNS	denotes	neurons
T5209	11542-11545	CC	denotes	and
T5210	11545-11547	,	denotes	,
T5211	11547-11559	RB	denotes	unexpectedly
T5212	11561-11568	IN	denotes	through
T5213	11559-11561	,	denotes	,
T5214	11569-11574	NN	denotes	E2f3a
T5215	11574-11576	,	denotes	,
T5216	11576-11579	CC	denotes	not
T5217	11580-11586	NN	denotes	tissue
T5218	11587-11595	JJ	denotes	specific
T5219	11586-11587	HYPH	denotes	-
T5220	11612-11619	NNS	denotes	factors
T5221	11596-11611	NN	denotes	differentiation
T5222	11619-11620	.	denotes	.
T6888	11631-11633	NN	denotes	Rb
T6889	11634-11643	VBZ	denotes	Regulates
T6890	11644-11652	NN	denotes	Division
T6891	11653-11656	CC	denotes	and
T6892	11657-11662	NN	denotes	Death
T6893	11663-11670	IN	denotes	through
T6894	11671-11675	NN	denotes	E2f1
T6895	11675-11781	sentence	denotes	We used the α-Cre transgene to delete floxed Rb exon 19 at embryonic day (E) 10 in peripheral retina [2].
T6896	11676-11678	PRP	denotes	We
T6897	11679-11683	VBD	denotes	used
T6898	11684-11687	DT	denotes	the
T6899	11694-11703	NN	denotes	transgene
T6900	11688-11689	NN	denotes	α
T6901	11690-11693	NN	denotes	Cre
T6902	11689-11690	HYPH	denotes	-
T6903	11704-11706	TO	denotes	to
T6904	11707-11713	VB	denotes	delete
T6905	11714-11720	VBN	denotes	floxed
T6906	11724-11728	NN	denotes	exon
T6907	11721-11723	NN	denotes	Rb
T6908	11729-11731	CD	denotes	19
T6909	11732-11734	IN	denotes	at
T6910	11735-11744	JJ	denotes	embryonic
T6911	11745-11748	NN	denotes	day
T6912	11749-11750	-LRB-	denotes	(
T6913	11750-11751	NN	denotes	E
T6914	11751-11752	-RRB-	denotes	)
T6915	11753-11755	CD	denotes	10
T6916	11756-11758	IN	denotes	in
T6917	11759-11769	JJ	denotes	peripheral
T6918	11770-11776	NN	denotes	retina
T6919	11777-11778	-LRB-	denotes	[
T6920	11778-11779	CD	denotes	2
T6921	11779-11780	-RRB-	denotes	]
T6922	11780-11781	.	denotes	.
T6923	11781-11913	sentence	denotes	RbloxP/loxP;α-Cre mice were bred with strains lacking E2f1 or E2f2 in the germ line, or a strain carrying a floxed E2f3 allele [5].
T6924	11782-11788	NN	denotes	RbloxP
T6925	11789-11793	NN	denotes	loxP
T6926	11788-11789	HYPH	denotes	/
T6927	11800-11804	NNS	denotes	mice
T6928	11793-11794	:	denotes	;
T6929	11794-11795	NN	denotes	α
T6930	11796-11799	NN	denotes	Cre
T6931	11795-11796	HYPH	denotes	-
T6932	11810-11814	VBN	denotes	bred
T6933	11805-11809	VBD	denotes	were
T6934	11815-11819	IN	denotes	with
T6935	11820-11827	NNS	denotes	strains
T6936	11828-11835	VBG	denotes	lacking
T6937	11836-11840	NN	denotes	E2f1
T6938	11841-11843	CC	denotes	or
T6939	11844-11848	NN	denotes	E2f2
T6940	11849-11851	IN	denotes	in
T6941	11852-11855	DT	denotes	the
T6942	11861-11865	NN	denotes	line
T6943	11856-11860	NN	denotes	germ
T6944	11865-11867	,	denotes	,
T6945	11867-11869	CC	denotes	or
T6946	11870-11871	DT	denotes	a
T6947	11872-11878	NN	denotes	strain
T6948	11879-11887	VBG	denotes	carrying
T6949	11888-11889	DT	denotes	a
T6950	11902-11908	NN	denotes	allele
T6951	11890-11896	VBN	denotes	floxed
T6952	11897-11901	NN	denotes	E2f3
T6953	11909-11910	-LRB-	denotes	[
T6954	11910-11911	CD	denotes	5
T6955	11911-11912	-RRB-	denotes	]
T6956	11912-11913	.	denotes	.
T6957	11913-12105	sentence	denotes	RbloxP/loxP;E2f1+/− and RbloxP/loxP;E2f1+/−;α-Cre mice were bred to produce RbloxP/loxP;E2f1−/−;α-Cre mice at a frequency of 1/8 and littermate controls at the same or higher (1/4) frequency.
T6958	11914-11920	NN	denotes	RbloxP
T6959	11921-11925	NN	denotes	loxP
T6960	11920-11921	HYPH	denotes	/
T6961	11964-11968	NNS	denotes	mice
T6962	11925-11926	:	denotes	;
T6963	11926-11930	NN	denotes	E2f1
T6964	11930-11931	SYM	denotes	+
T6965	11931-11932	HYPH	denotes	/
T6966	11932-11933	SYM	denotes	−
T6967	11934-11937	CC	denotes	and
T6968	11938-11944	NN	denotes	RbloxP
T6969	11945-11949	NN	denotes	loxP
T6970	11944-11945	HYPH	denotes	/
T6971	11949-11950	:	denotes	;
T6972	11950-11954	NN	denotes	E2f1
T6973	11954-11955	SYM	denotes	+
T6974	11955-11956	HYPH	denotes	/
T6975	11956-11957	SYM	denotes	−
T6976	11957-11958	:	denotes	;
T6977	11958-11959	NN	denotes	α
T6978	11960-11963	NN	denotes	Cre
T6979	11959-11960	HYPH	denotes	-
T6980	11974-11978	VBN	denotes	bred
T6981	11969-11973	VBD	denotes	were
T6982	11979-11981	TO	denotes	to
T6983	11982-11989	VB	denotes	produce
T6984	11990-11996	NN	denotes	RbloxP
T6985	11997-12001	NN	denotes	loxP
T6986	11996-11997	HYPH	denotes	/
T6987	12016-12020	NNS	denotes	mice
T6988	12001-12002	:	denotes	;
T6989	12002-12006	NN	denotes	E2f1
T6990	12006-12007	SYM	denotes	−
T6991	12007-12008	HYPH	denotes	/
T6992	12008-12009	SYM	denotes	−
T6993	12009-12010	:	denotes	;
T6994	12010-12011	NN	denotes	α
T6995	12012-12015	NN	denotes	Cre
T6996	12011-12012	HYPH	denotes	-
T6997	12021-12023	IN	denotes	at
T6998	12024-12025	DT	denotes	a
T6999	12026-12035	NN	denotes	frequency
T7000	12036-12038	IN	denotes	of
T7001	12039-12040	CD	denotes	1
T7002	12041-12042	CD	denotes	8
T7003	12040-12041	SYM	denotes	/
T7004	12043-12046	CC	denotes	and
T7005	12047-12057	NN	denotes	littermate
T7006	12058-12066	NNS	denotes	controls
T7007	12067-12069	IN	denotes	at
T7008	12070-12073	DT	denotes	the
T7009	12074-12078	JJ	denotes	same
T7010	12079-12081	CC	denotes	or
T7011	12082-12088	JJR	denotes	higher
T7012	12095-12104	NN	denotes	frequency
T7013	12089-12090	-LRB-	denotes	(
T7014	12090-12091	CD	denotes	1
T7015	12091-12092	SYM	denotes	/
T7016	12092-12093	CD	denotes	4
T7017	12093-12094	-RRB-	denotes	)
T7018	12104-12105	.	denotes	.
T7019	12105-12230	sentence	denotes	For simplicity we will refer to the RbloxP/loxP;E2f1−/−;α-Cre peripheral retina as the Rb/E2f1 double knockout (DKO) retina.
T7020	12106-12109	IN	denotes	For
T7021	12129-12134	VB	denotes	refer
T7022	12110-12120	NN	denotes	simplicity
T7023	12121-12123	PRP	denotes	we
T7024	12124-12128	MD	denotes	will
T7025	12135-12137	IN	denotes	to
T7026	12138-12141	DT	denotes	the
T7027	12179-12185	NN	denotes	retina
T7028	12142-12148	NN	denotes	RbloxP
T7029	12149-12153	NN	denotes	loxP
T7030	12148-12149	HYPH	denotes	/
T7031	12153-12154	:	denotes	;
T7032	12154-12158	NN	denotes	E2f1
T7033	12158-12159	SYM	denotes	−
T7034	12159-12160	HYPH	denotes	/
T7035	12160-12161	SYM	denotes	−
T7036	12161-12162	:	denotes	;
T7037	12162-12163	NN	denotes	α
T7038	12164-12167	NN	denotes	Cre
T7039	12163-12164	HYPH	denotes	-
T7040	12168-12178	JJ	denotes	peripheral
T7041	12186-12188	IN	denotes	as
T7042	12189-12192	DT	denotes	the
T7043	12223-12229	NN	denotes	retina
T7044	12193-12195	NN	denotes	Rb
T7045	12196-12200	NN	denotes	E2f1
T7046	12195-12196	HYPH	denotes	/
T7047	12201-12207	JJ	denotes	double
T7048	12208-12216	NN	denotes	knockout
T7049	12217-12218	-LRB-	denotes	(
T7050	12218-12221	NN	denotes	DKO
T7051	12221-12222	-RRB-	denotes	)
T7052	12229-12230	.	denotes	.
T7053	12230-12292	sentence	denotes	Similar strategies were employed in the case of E2f2 or E2f3.
T7054	12231-12238	JJ	denotes	Similar
T7055	12239-12249	NNS	denotes	strategies
T7056	12255-12263	VBN	denotes	employed
T7057	12250-12254	VBD	denotes	were
T7058	12264-12266	IN	denotes	in
T7059	12267-12270	DT	denotes	the
T7060	12271-12275	NN	denotes	case
T7061	12276-12278	IN	denotes	of
T7062	12279-12283	NN	denotes	E2f2
T7063	12284-12286	CC	denotes	or
T7064	12287-12291	NN	denotes	E2f3
T7065	12291-12292	.	denotes	.
T7066	12292-12403	sentence	denotes	Cre-mediated excision of Rb and E2f3 alleles in the retina was confirmed by PCR as described previously [2,5].
T7067	12293-12296	NN	denotes	Cre
T7068	12297-12305	VBN	denotes	mediated
T7069	12296-12297	HYPH	denotes	-
T7070	12306-12314	NN	denotes	excision
T7071	12356-12365	VBN	denotes	confirmed
T7072	12315-12317	IN	denotes	of
T7073	12318-12320	NN	denotes	Rb
T7074	12330-12337	NNS	denotes	alleles
T7075	12321-12324	CC	denotes	and
T7076	12325-12329	NN	denotes	E2f3
T7077	12338-12340	IN	denotes	in
T7078	12341-12344	DT	denotes	the
T7079	12345-12351	NN	denotes	retina
T7080	12352-12355	VBD	denotes	was
T7081	12366-12368	IN	denotes	by
T7082	12369-12372	NN	denotes	PCR
T7083	12373-12375	IN	denotes	as
T7084	12376-12385	VBN	denotes	described
T7085	12386-12396	RB	denotes	previously
T7086	12397-12398	-LRB-	denotes	[
T7087	12400-12401	CD	denotes	5
T7088	12398-12399	CD	denotes	2
T7089	12399-12400	,	denotes	,
T7090	12401-12402	-RRB-	denotes	]
T7091	12402-12403	.	denotes	.
T7092	12403-12594	sentence	denotes	To measure ectopic cell division, mice were pulse-labelled with bromodeoxyuridine (BrdU) 2 h before sacrifice and the peripheral retina analyzed for BrdU incorporation by immunofluorescence.
T7093	12404-12406	TO	denotes	To
T7094	12407-12414	VB	denotes	measure
T7095	12454-12462	VBN	denotes	labelled
T7096	12415-12422	JJ	denotes	ectopic
T7097	12428-12436	NN	denotes	division
T7098	12423-12427	NN	denotes	cell
T7099	12436-12438	,	denotes	,
T7100	12438-12442	NNS	denotes	mice
T7101	12443-12447	VBD	denotes	were
T7102	12448-12453	NN	denotes	pulse
T7103	12453-12454	HYPH	denotes	-
T7104	12463-12467	IN	denotes	with
T7105	12468-12485	NN	denotes	bromodeoxyuridine
T7106	12486-12487	-LRB-	denotes	(
T7107	12487-12491	NN	denotes	BrdU
T7108	12491-12492	-RRB-	denotes	)
T7109	12493-12494	CD	denotes	2
T7110	12495-12496	NN	denotes	h
T7111	12497-12503	IN	denotes	before
T7112	12504-12513	NN	denotes	sacrifice
T7113	12514-12517	CC	denotes	and
T7114	12518-12521	DT	denotes	the
T7115	12533-12539	NN	denotes	retina
T7116	12522-12532	JJ	denotes	peripheral
T7117	12540-12548	VBN	denotes	analyzed
T7118	12549-12552	IN	denotes	for
T7119	12553-12557	NN	denotes	BrdU
T7120	12558-12571	NN	denotes	incorporation
T7121	12572-12574	IN	denotes	by
T7122	12575-12593	NN	denotes	immunofluorescence
T7123	12593-12594	.	denotes	.
T7124	12594-12714	sentence	denotes	As reported before [2,3], Rb KO retinas exhibited both spatial and temporal ectopic DNA synthesis (Figures 1C and S1A).
T7125	12595-12597	IN	denotes	As
T7126	12598-12606	VBN	denotes	reported
T7127	12635-12644	VBD	denotes	exhibited
T7128	12607-12613	RB	denotes	before
T7129	12614-12615	-LRB-	denotes	[
T7130	12617-12618	CD	denotes	3
T7131	12615-12616	CD	denotes	2
T7132	12616-12617	,	denotes	,
T7133	12618-12619	-RRB-	denotes	]
T7134	12619-12621	DT	denotes	,
T7135	12621-12623	NN	denotes	Rb
T7136	12624-12626	NN	denotes	KO
T7137	12627-12634	NNS	denotes	retinas
T7138	12645-12649	CC	denotes	both
T7139	12650-12657	JJ	denotes	spatial
T7140	12683-12692	NN	denotes	synthesis
T7141	12658-12661	CC	denotes	and
T7142	12662-12670	JJ	denotes	temporal
T7143	12671-12678	JJ	denotes	ectopic
T7144	12679-12682	NN	denotes	DNA
T7145	12693-12694	-LRB-	denotes	(
T7146	12702-12704	NN	denotes	1C
T7147	12694-12701	NNS	denotes	Figures
T7148	12705-12708	CC	denotes	and
T7149	12709-12712	NN	denotes	S1A
T7150	12712-12713	-RRB-	denotes	)
T7151	12713-12714	.	denotes	.
T7152	12714-12973	sentence	denotes	This is easily detected at E14, E16, and postnatal day (P) 0 in the inner retina where abnormal BrdU+ ganglion and amacrine RTCs are located, or on the outermost region of the P0 retina, where BrdU+ photoreceptor RTCs reside (Figures S1A and S2, arrows) [2].
T7153	12715-12719	DT	denotes	This
T7154	12730-12738	VBN	denotes	detected
T7155	12720-12722	VBZ	denotes	is
T7156	12723-12729	RB	denotes	easily
T7157	12739-12741	IN	denotes	at
T7158	12742-12745	NN	denotes	E14
T7159	12745-12747	,	denotes	,
T7160	12747-12750	NN	denotes	E16
T7161	12750-12752	,	denotes	,
T7162	12752-12755	CC	denotes	and
T7163	12756-12765	JJ	denotes	postnatal
T7164	12766-12769	NN	denotes	day
T7165	12770-12771	-LRB-	denotes	(
T7166	12771-12772	NN	denotes	P
T7167	12772-12773	-RRB-	denotes	)
T7168	12774-12775	CD	denotes	0
T7169	12776-12778	IN	denotes	in
T7170	12779-12782	DT	denotes	the
T7171	12789-12795	NN	denotes	retina
T7172	12783-12788	JJ	denotes	inner
T7173	12796-12801	WRB	denotes	where
T7174	12848-12855	VBN	denotes	located
T7175	12802-12810	JJ	denotes	abnormal
T7176	12839-12843	NNS	denotes	RTCs
T7177	12811-12815	NN	denotes	BrdU
T7178	12815-12816	SYM	denotes	+
T7179	12817-12825	NN	denotes	ganglion
T7180	12826-12829	CC	denotes	and
T7181	12830-12838	JJ	denotes	amacrine
T7182	12844-12847	VBP	denotes	are
T7183	12855-12857	,	denotes	,
T7184	12857-12859	CC	denotes	or
T7185	12860-12862	IN	denotes	on
T7186	12863-12866	DT	denotes	the
T7187	12877-12883	NN	denotes	region
T7188	12867-12876	JJ	denotes	outermost
T7189	12884-12886	IN	denotes	of
T7190	12887-12890	DT	denotes	the
T7191	12894-12900	NN	denotes	retina
T7192	12891-12893	NN	denotes	P0
T7193	12900-12902	,	denotes	,
T7194	12902-12907	WRB	denotes	where
T7195	12933-12939	VBP	denotes	reside
T7196	12908-12912	NN	denotes	BrdU
T7197	12928-12932	NNS	denotes	RTCs
T7198	12912-12913	SYM	denotes	+
T7199	12914-12927	NN	denotes	photoreceptor
T7200	12940-12941	-LRB-	denotes	(
T7201	12961-12967	NNS	denotes	arrows
T7202	12941-12948	NNS	denotes	Figures
T7203	12949-12952	NN	denotes	S1A
T7204	12953-12956	CC	denotes	and
T7205	12957-12959	NN	denotes	S2
T7206	12959-12961	,	denotes	,
T7207	12967-12968	-RRB-	denotes	)
T7208	12969-12970	-LRB-	denotes	[
T7209	12970-12971	CD	denotes	2
T7210	12971-12972	-RRB-	denotes	]
T7211	12972-12973	.	denotes	.
T7212	12973-13120	sentence	denotes	Ectopic RTC division in Rb KO retinas is even more obvious at P8 or P18, when division is completed in wild-type (WT) retina (Figures 1C and S1A).
T7213	12974-12981	JJ	denotes	Ectopic
T7214	12986-12994	NN	denotes	division
T7215	12982-12985	NN	denotes	RTC
T7216	13012-13014	VBZ	denotes	is
T7217	12995-12997	IN	denotes	in
T7218	12998-13000	NN	denotes	Rb
T7219	13001-13003	NN	denotes	KO
T7220	13004-13011	NNS	denotes	retinas
T7221	13015-13019	RB	denotes	even
T7222	13020-13024	RBR	denotes	more
T7223	13025-13032	JJ	denotes	obvious
T7224	13033-13035	IN	denotes	at
T7225	13036-13038	NN	denotes	P8
T7226	13039-13041	CC	denotes	or
T7227	13042-13045	NN	denotes	P18
T7228	13045-13047	,	denotes	,
T7229	13047-13051	WRB	denotes	when
T7230	13064-13073	VBN	denotes	completed
T7231	13052-13060	NN	denotes	division
T7232	13061-13063	VBZ	denotes	is
T7233	13074-13076	IN	denotes	in
T7234	13077-13081	JJ	denotes	wild
T7235	13082-13086	NN	denotes	type
T7236	13081-13082	HYPH	denotes	-
T7237	13092-13098	NN	denotes	retina
T7238	13087-13088	-LRB-	denotes	(
T7239	13088-13090	NN	denotes	WT
T7240	13090-13091	-RRB-	denotes	)
T7241	13099-13100	-LRB-	denotes	(
T7242	13108-13110	NN	denotes	1C
T7243	13100-13107	NNS	denotes	Figures
T7244	13111-13114	CC	denotes	and
T7245	13115-13118	NN	denotes	S1A
T7246	13118-13119	-RRB-	denotes	)
T7247	13119-13120	.	denotes	.
T7248	13120-13325	sentence	denotes	Strikingly, the ectopically positioned S-phase cells at E14, E16, and P0 and all the abnormal division at P8 and P18 were completely suppressed in the Rb/E2f1 DKO retina (Figures 1C, 1E, 1F, S1A, and S2).
T7249	13121-13131	RB	denotes	Strikingly
T7250	13254-13264	VBN	denotes	suppressed
T7251	13131-13133	,	denotes	,
T7252	13133-13136	DT	denotes	the
T7253	13168-13173	NNS	denotes	cells
T7254	13137-13148	RB	denotes	ectopically
T7255	13149-13159	VBN	denotes	positioned
T7256	13160-13161	NN	denotes	S
T7257	13162-13167	NN	denotes	phase
T7258	13161-13162	HYPH	denotes	-
T7259	13174-13176	IN	denotes	at
T7260	13177-13180	NN	denotes	E14
T7261	13180-13182	,	denotes	,
T7262	13182-13185	NN	denotes	E16
T7263	13185-13187	,	denotes	,
T7264	13187-13190	CC	denotes	and
T7265	13191-13193	NN	denotes	P0
T7266	13194-13197	CC	denotes	and
T7267	13198-13201	PDT	denotes	all
T7268	13215-13223	NN	denotes	division
T7269	13202-13205	DT	denotes	the
T7270	13206-13214	JJ	denotes	abnormal
T7271	13224-13226	IN	denotes	at
T7272	13227-13229	NN	denotes	P8
T7273	13230-13233	CC	denotes	and
T7274	13234-13237	NN	denotes	P18
T7275	13238-13242	VBD	denotes	were
T7276	13243-13253	RB	denotes	completely
T7277	13265-13267	IN	denotes	in
T7278	13268-13271	DT	denotes	the
T7279	13284-13290	NN	denotes	retina
T7280	13272-13274	NN	denotes	Rb
T7281	13275-13279	NN	denotes	E2f1
T7282	13274-13275	HYPH	denotes	/
T7283	13280-13283	NN	denotes	DKO
T7284	13291-13292	-LRB-	denotes	(
T7285	13300-13302	NN	denotes	1C
T7286	13292-13299	NNS	denotes	Figures
T7287	13302-13304	,	denotes	,
T7288	13304-13306	NN	denotes	1E
T7289	13306-13308	,	denotes	,
T7290	13308-13310	NN	denotes	1F
T7291	13310-13312	,	denotes	,
T7292	13312-13315	NN	denotes	S1A
T7293	13315-13317	,	denotes	,
T7294	13317-13320	CC	denotes	and
T7295	13321-13323	NN	denotes	S2
T7296	13323-13324	-RRB-	denotes	)
T7297	13324-13325	.	denotes	.
T7298	13325-13406	sentence	denotes	In contrast, deletion of E2f2 or E2f3 had no effect at any stage of development.
T7299	13326-13328	IN	denotes	In
T7300	13364-13367	VBD	denotes	had
T7301	13329-13337	NN	denotes	contrast
T7302	13337-13339	,	denotes	,
T7303	13339-13347	NN	denotes	deletion
T7304	13348-13350	IN	denotes	of
T7305	13351-13355	NN	denotes	E2f2
T7306	13356-13358	CC	denotes	or
T7307	13359-13363	NN	denotes	E2f3
T7308	13368-13370	DT	denotes	no
T7309	13371-13377	NN	denotes	effect
T7310	13378-13380	IN	denotes	at
T7311	13381-13384	DT	denotes	any
T7312	13385-13390	NN	denotes	stage
T7313	13391-13393	IN	denotes	of
T7314	13394-13405	NN	denotes	development
T7315	13405-13406	.	denotes	.
T7316	13406-13577	sentence	denotes	Analysis of mitotic cells with anti–phosphohistone 3 (PH3)–specific antibodies confirmed that loss of E2f1, but not E2f2 or E2f3, suppressed ectopic division (Figure S3).
T7317	13407-13415	NN	denotes	Analysis
T7318	13486-13495	VBD	denotes	confirmed
T7319	13416-13418	IN	denotes	of
T7320	13419-13426	JJ	denotes	mitotic
T7321	13427-13432	NNS	denotes	cells
T7322	13433-13437	IN	denotes	with
T7323	13438-13457	NN	denotes	anti–phosphohistone
T7324	13466-13474	JJ	denotes	specific
T7325	13458-13459	CD	denotes	3
T7326	13460-13461	-LRB-	denotes	(
T7327	13461-13464	NN	denotes	PH3
T7328	13464-13465	-RRB-	denotes	)
T7329	13465-13466	HYPH	denotes	–
T7330	13475-13485	NNS	denotes	antibodies
T7331	13496-13500	IN	denotes	that
T7332	13537-13547	VBD	denotes	suppressed
T7333	13501-13505	NN	denotes	loss
T7334	13506-13508	IN	denotes	of
T7335	13509-13513	NN	denotes	E2f1
T7336	13513-13515	,	denotes	,
T7337	13515-13518	CC	denotes	but
T7338	13519-13522	RB	denotes	not
T7339	13523-13527	NN	denotes	E2f2
T7340	13528-13530	CC	denotes	or
T7341	13531-13535	NN	denotes	E2f3
T7342	13535-13537	,	denotes	,
T7343	13548-13555	JJ	denotes	ectopic
T7344	13556-13564	NN	denotes	division
T7345	13565-13566	-LRB-	denotes	(
T7346	13573-13575	NN	denotes	S3
T7347	13566-13572	NN	denotes	Figure
T7348	13575-13576	-RRB-	denotes	)
T7349	13576-13577	.	denotes	.
T7350	13577-13792	sentence	denotes	Deleting one E2f1 allele partially suppressed ectopic S-phase and mitosis in Rb KO RTCs (Figures 1C, 1E, 1F, S1A, S2, and S3), suggesting that E2f1 drives ectopic division in Rb KO RTCs in a dose-dependent fashion.
T7351	13578-13586	VBG	denotes	Deleting
T7352	13613-13623	VBD	denotes	suppressed
T7353	13587-13590	CD	denotes	one
T7354	13596-13602	NN	denotes	allele
T7355	13591-13595	NN	denotes	E2f1
T7356	13603-13612	RB	denotes	partially
T7357	13624-13631	JJ	denotes	ectopic
T7358	13634-13639	NN	denotes	phase
T7359	13632-13633	NN	denotes	S
T7360	13633-13634	HYPH	denotes	-
T7361	13640-13643	CC	denotes	and
T7362	13644-13651	NN	denotes	mitosis
T7363	13652-13654	IN	denotes	in
T7364	13655-13657	NN	denotes	Rb
T7365	13658-13660	NN	denotes	KO
T7366	13661-13665	NNS	denotes	RTCs
T7367	13666-13667	-LRB-	denotes	(
T7368	13675-13677	NN	denotes	1C
T7369	13667-13674	NNS	denotes	Figures
T7370	13677-13679	,	denotes	,
T7371	13679-13681	NN	denotes	1E
T7372	13681-13683	,	denotes	,
T7373	13683-13685	NN	denotes	1F
T7374	13685-13687	,	denotes	,
T7375	13687-13690	NN	denotes	S1A
T7376	13690-13692	,	denotes	,
T7377	13692-13694	NN	denotes	S2
T7378	13694-13696	,	denotes	,
T7379	13696-13699	CC	denotes	and
T7380	13700-13702	NN	denotes	S3
T7381	13702-13703	-RRB-	denotes	)
T7382	13703-13705	,	denotes	,
T7383	13705-13715	VBG	denotes	suggesting
T7384	13716-13720	IN	denotes	that
T7385	13726-13732	VBZ	denotes	drives
T7386	13721-13725	NN	denotes	E2f1
T7387	13733-13740	JJ	denotes	ectopic
T7388	13741-13749	NN	denotes	division
T7389	13750-13752	IN	denotes	in
T7390	13753-13755	NN	denotes	Rb
T7391	13756-13758	NN	denotes	KO
T7392	13759-13763	NNS	denotes	RTCs
T7393	13764-13766	IN	denotes	in
T7394	13767-13768	DT	denotes	a
T7395	13784-13791	NN	denotes	fashion
T7396	13769-13773	NN	denotes	dose
T7397	13774-13783	JJ	denotes	dependent
T7398	13773-13774	HYPH	denotes	-
T7399	13791-13792	.	denotes	.
T7400	13792-13960	sentence	denotes	These data contrast with previous findings in the lens and CNS of Rb KO embryos, where deletion of any activating E2f suppresses ectopic division to some extent [6–9].
T7401	13793-13798	DT	denotes	These
T7402	13799-13803	NNS	denotes	data
T7403	13804-13812	VBP	denotes	contrast
T7404	13813-13817	IN	denotes	with
T7405	13818-13826	JJ	denotes	previous
T7406	13827-13835	NNS	denotes	findings
T7407	13836-13838	IN	denotes	in
T7408	13839-13842	DT	denotes	the
T7409	13843-13847	NN	denotes	lens
T7410	13848-13851	CC	denotes	and
T7411	13852-13855	NN	denotes	CNS
T7412	13856-13858	IN	denotes	of
T7413	13859-13861	NN	denotes	Rb
T7414	13862-13864	NN	denotes	KO
T7415	13865-13872	NNS	denotes	embryos
T7416	13872-13874	,	denotes	,
T7417	13874-13879	WRB	denotes	where
T7418	13911-13921	VBZ	denotes	suppresses
T7419	13880-13888	NN	denotes	deletion
T7420	13889-13891	IN	denotes	of
T7421	13892-13895	DT	denotes	any
T7422	13907-13910	NN	denotes	E2f
T7423	13896-13906	VBG	denotes	activating
T7424	13922-13929	JJ	denotes	ectopic
T7425	13930-13938	NN	denotes	division
T7426	13939-13941	IN	denotes	to
T7427	13942-13946	DT	denotes	some
T7428	13947-13953	NN	denotes	extent
T7429	13954-13955	-LRB-	denotes	[
T7430	13955-13956	CD	denotes	6
T7431	13956-13957	SYM	denotes	–
T7432	13957-13958	CD	denotes	9
T7433	13958-13959	-RRB-	denotes	]
T7434	13959-13960	.	denotes	.
T7435	13960-14111	sentence	denotes	Loss of Rb in the retina results in considerable RTC apoptosis, eliminating most bipolar and ganglion cells as well as many rods (Figure 2A–2D) [2,3].
T7436	13961-13965	NN	denotes	Loss
T7437	13986-13993	VBZ	denotes	results
T7438	13966-13968	IN	denotes	of
T7439	13969-13971	NN	denotes	Rb
T7440	13972-13974	IN	denotes	in
T7441	13975-13978	DT	denotes	the
T7442	13979-13985	NN	denotes	retina
T7443	13994-13996	IN	denotes	in
T7444	13997-14009	JJ	denotes	considerable
T7445	14014-14023	NN	denotes	apoptosis
T7446	14010-14013	NN	denotes	RTC
T7447	14023-14025	,	denotes	,
T7448	14025-14036	VBG	denotes	eliminating
T7449	14037-14041	JJS	denotes	most
T7450	14063-14068	NNS	denotes	cells
T7451	14042-14049	JJ	denotes	bipolar
T7452	14050-14053	CC	denotes	and
T7453	14054-14062	NN	denotes	ganglion
T7454	14069-14071	RB	denotes	as
T7455	14077-14079	IN	denotes	as
T7456	14072-14076	RB	denotes	well
T7457	14080-14084	JJ	denotes	many
T7458	14085-14089	NNS	denotes	rods
T7459	14090-14091	-LRB-	denotes	(
T7460	14098-14100	NN	denotes	2A
T7461	14091-14097	NN	denotes	Figure
T7462	14100-14101	SYM	denotes	–
T7463	14101-14103	NN	denotes	2D
T7464	14103-14104	-RRB-	denotes	)
T7465	14105-14106	-LRB-	denotes	[
T7466	14108-14109	CD	denotes	3
T7467	14106-14107	CD	denotes	2
T7468	14107-14108	,	denotes	,
T7469	14109-14110	-RRB-	denotes	]
T7470	14110-14111	.	denotes	.
T7471	14111-14367	sentence	denotes	The loss of Rb KO rods is evident from the thinner ONL, and the death of these cells as well as bipolar and ganglion neurons can be detected directly by double labelling for apoptotic and cell-type-specific markers [2] (M. P. and R. B., unpublished data).
T7472	14112-14115	DT	denotes	The
T7473	14116-14120	NN	denotes	loss
T7474	14135-14137	VBZ	denotes	is
T7475	14121-14123	IN	denotes	of
T7476	14124-14126	NN	denotes	Rb
T7477	14127-14129	NN	denotes	KO
T7478	14130-14134	NNS	denotes	rods
T7479	14138-14145	JJ	denotes	evident
T7480	14146-14150	IN	denotes	from
T7481	14151-14154	DT	denotes	the
T7482	14163-14166	NN	denotes	ONL
T7483	14155-14162	JJ	denotes	thinner
T7484	14166-14168	,	denotes	,
T7485	14168-14171	CC	denotes	and
T7486	14172-14175	DT	denotes	the
T7487	14176-14181	NN	denotes	death
T7488	14244-14252	VBN	denotes	detected
T7489	14182-14184	IN	denotes	of
T7490	14185-14190	DT	denotes	these
T7491	14191-14196	NNS	denotes	cells
T7492	14197-14199	RB	denotes	as
T7493	14205-14207	IN	denotes	as
T7494	14200-14204	RB	denotes	well
T7495	14208-14215	JJ	denotes	bipolar
T7496	14229-14236	NNS	denotes	neurons
T7497	14216-14219	CC	denotes	and
T7498	14220-14228	NN	denotes	ganglion
T7499	14237-14240	MD	denotes	can
T7500	14241-14243	VB	denotes	be
T7501	14253-14261	RB	denotes	directly
T7502	14262-14264	IN	denotes	by
T7503	14265-14271	RB	denotes	double
T7504	14272-14281	VBG	denotes	labelling
T7505	14282-14285	IN	denotes	for
T7506	14286-14295	JJ	denotes	apoptotic
T7507	14319-14326	NNS	denotes	markers
T7508	14296-14299	CC	denotes	and
T7509	14300-14304	NN	denotes	cell
T7510	14305-14309	NN	denotes	type
T7511	14304-14305	HYPH	denotes	-
T7512	14310-14318	JJ	denotes	specific
T7513	14309-14310	HYPH	denotes	-
T7514	14327-14328	-LRB-	denotes	[
T7515	14328-14329	CD	denotes	2
T7516	14329-14330	-RRB-	denotes	]
T7517	14331-14332	-LRB-	denotes	(
T7518	14332-14334	NNP	denotes	M.
T7519	14335-14337	NNP	denotes	P.
T7520	14338-14341	CC	denotes	and
T7521	14342-14344	NNP	denotes	R.
T7522	14345-14347	NNP	denotes	B.
T7523	14347-14349	,	denotes	,
T7524	14349-14360	JJ	denotes	unpublished
T7525	14361-14365	NNS	denotes	data
T7526	14365-14366	-RRB-	denotes	)
T7527	14366-14367	.	denotes	.
T7528	14367-14493	sentence	denotes	Loss of peripheral Rb KO ganglion cells is also evident from thinning of the optic nerve (D. C. and R. B., unpublished data).
T7529	14368-14372	NN	denotes	Loss
T7530	14408-14410	VBZ	denotes	is
T7531	14373-14375	IN	denotes	of
T7532	14376-14386	JJ	denotes	peripheral
T7533	14402-14407	NNS	denotes	cells
T7534	14387-14389	NN	denotes	Rb
T7535	14390-14392	NN	denotes	KO
T7536	14393-14401	NN	denotes	ganglion
T7537	14411-14415	RB	denotes	also
T7538	14416-14423	JJ	denotes	evident
T7539	14424-14428	IN	denotes	from
T7540	14429-14437	VBG	denotes	thinning
T7541	14438-14440	IN	denotes	of
T7542	14441-14444	DT	denotes	the
T7543	14451-14456	NN	denotes	nerve
T7544	14445-14450	JJ	denotes	optic
T7545	14457-14458	-LRB-	denotes	(
T7546	14458-14460	NNP	denotes	D.
T7547	14461-14463	NNP	denotes	C.
T7548	14464-14467	CC	denotes	and
T7549	14468-14470	NNP	denotes	R.
T7550	14471-14473	NNP	denotes	B.
T7551	14473-14475	,	denotes	,
T7552	14475-14486	JJ	denotes	unpublished
T7553	14487-14491	NNS	denotes	data
T7554	14491-14492	-RRB-	denotes	)
T7555	14492-14493	.	denotes	.
T7597	16004-16008	NN	denotes	role
T7598	15997-16003	JJ	denotes	unique
T7599	16009-16011	IN	denotes	of
T7600	16012-16016	NN	denotes	E2f1
T7601	16016-16018	,	denotes	,
T7602	16018-16020	PRP	denotes	we
T7603	16030-16033	DT	denotes	the
T7604	16034-16044	NN	denotes	expression
T7605	16045-16047	IN	denotes	of
T7606	16048-16053	JJ	denotes	known
T7607	16058-16065	NNS	denotes	targets
T7608	16054-16057	NN	denotes	E2f
T7609	16066-16068	RB	denotes	as
T7610	16074-16076	IN	denotes	as
T7611	16069-16073	RB	denotes	well
T7612	16077-16082	JJ	denotes	other
T7613	16083-16088	NNS	denotes	genes
T7614	16089-16093	WDT	denotes	that
T7615	16094-16102	VBP	denotes	regulate
T7616	16103-16106	DT	denotes	the
T7617	16112-16117	NN	denotes	cycle
T7618	16107-16111	NN	denotes	cell
T7619	16118-16121	CC	denotes	and
T7620	16122-16131	NN	denotes	apoptosis
T7621	16131-16132	.	denotes	.
T7622	16132-16250	sentence	denotes	Numerous positive and negative cell cycle and apoptotic regulators were up-regulated in the Rb KO retina (Figure 1H).
T7623	16133-16141	JJ	denotes	Numerous
T7624	16169-16174	NN	denotes	cycle
T7625	16142-16150	JJ	denotes	positive
T7626	16151-16154	CC	denotes	and
T7627	16155-16163	JJ	denotes	negative
T7628	16164-16168	NN	denotes	cell
T7629	16208-16217	VBN	denotes	regulated
T7630	16175-16178	CC	denotes	and
T7631	16179-16188	JJ	denotes	apoptotic
T7632	16189-16199	NNS	denotes	regulators
T7633	16200-16204	VBD	denotes	were
T7634	16205-16207	RB	denotes	up
T7635	16207-16208	HYPH	denotes	-
T7636	16218-16220	IN	denotes	in
T7637	16221-16224	DT	denotes	the
T7638	16231-16237	NN	denotes	retina
T7639	16225-16227	NN	denotes	Rb
T7640	16228-16230	NN	denotes	KO
T7641	16238-16239	-LRB-	denotes	(
T7642	16246-16248	NN	denotes	1H
T7643	16239-16245	NN	denotes	Figure
T7644	16248-16249	-RRB-	denotes	)
T7645	16249-16250	.	denotes	.
T7646	16250-16375	sentence	denotes	Among the E2f family, E2f1, E2f2, E2f3a, and E2f7 were induced following Rb loss, but E2f3b, E2f4, and E2f5 were unaffected.
T7647	16251-16256	IN	denotes	Among
T7648	16306-16313	VBN	denotes	induced
T7649	16257-16260	DT	denotes	the
T7650	16265-16271	NN	denotes	family
T7651	16261-16264	NN	denotes	E2f
T7652	16271-16273	,	denotes	,
T7653	16273-16277	NN	denotes	E2f1
T7654	16277-16279	,	denotes	,
T7655	16279-16283	NN	denotes	E2f2
T7656	16283-16285	,	denotes	,
T7657	16285-16290	NN	denotes	E2f3a
T7658	16290-16292	,	denotes	,
T7659	16292-16295	CC	denotes	and
T7660	16296-16300	NN	denotes	E2f7
T7661	16301-16305	VBD	denotes	were
T7662	16314-16323	VBG	denotes	following
T7663	16324-16326	NN	denotes	Rb
T7664	16327-16331	NN	denotes	loss
T7665	16331-16333	,	denotes	,
T7666	16333-16336	CC	denotes	but
T7667	16337-16342	NN	denotes	E2f3b
T7668	16359-16363	VBD	denotes	were
T7669	16342-16344	,	denotes	,
T7670	16344-16348	NN	denotes	E2f4
T7671	16348-16350	,	denotes	,
T7672	16350-16353	CC	denotes	and
T7673	16354-16358	NN	denotes	E2f5
T7674	16364-16374	JJ	denotes	unaffected
T7675	16374-16375	.	denotes	.
T7676	16375-16565	sentence	denotes	Consistent with the BrdU and terminal dUTP nick-end labelling (TUNEL) analyses, E2f1 deletion specifically reversed all these molecular defects, but E2f3 deletion had no effect (Figure 1H).
T7677	16376-16386	JJ	denotes	Consistent
T7678	16483-16491	VBD	denotes	reversed
T7679	16387-16391	IN	denotes	with
T7680	16392-16395	DT	denotes	the
T7681	16446-16454	NNS	denotes	analyses
T7682	16396-16400	NN	denotes	BrdU
T7683	16401-16404	CC	denotes	and
T7684	16405-16413	JJ	denotes	terminal
T7685	16428-16437	NN	denotes	labelling
T7686	16414-16418	NN	denotes	dUTP
T7687	16419-16423	NN	denotes	nick
T7688	16423-16424	HYPH	denotes	-
T7689	16424-16427	NN	denotes	end
T7690	16438-16439	-LRB-	denotes	(
T7691	16439-16444	NN	denotes	TUNEL
T7692	16444-16445	-RRB-	denotes	)
T7693	16454-16456	,	denotes	,
T7694	16456-16460	NN	denotes	E2f1
T7695	16461-16469	NN	denotes	deletion
T7696	16470-16482	RB	denotes	specifically
T7697	16492-16495	PDT	denotes	all
T7698	16512-16519	NNS	denotes	defects
T7699	16496-16501	DT	denotes	these
T7700	16502-16511	JJ	denotes	molecular
T7701	16519-16521	,	denotes	,
T7702	16521-16524	CC	denotes	but
T7703	16525-16529	NN	denotes	E2f3
T7704	16530-16538	NN	denotes	deletion
T7705	16539-16542	VBD	denotes	had
T7706	16543-16545	DT	denotes	no
T7707	16546-16552	NN	denotes	effect
T7708	16553-16554	-LRB-	denotes	(
T7709	16561-16563	NN	denotes	1H
T7710	16554-16560	NN	denotes	Figure
T7711	16563-16564	-RRB-	denotes	)
T7712	16564-16565	.	denotes	.
T16891	31878-31879	-LRB-	denotes	(
T16892	31886-31888	NN	denotes	4C
T9110	16567-16573	JJ	denotes	Normal
T9111	16574-16589	NN	denotes	Differentiation
T9112	16590-16592	IN	denotes	in
T9113	16593-16596	DT	denotes	the
T9114	16609-16615	NN	denotes	Retina
T9115	16597-16599	NN	denotes	Rb
T9116	16600-16604	NN	denotes	E2f1
T9117	16599-16600	HYPH	denotes	/
T9118	16605-16608	NNP	denotes	DKO
T9119	16615-16829	sentence	denotes	Because E2f1 deletion blocks abnormal division and death in the Rb KO retina, the Rb/E2f1 DKO retina provided a unique opportunity to evaluate whether Rb controls differentiation independent of cell cycle effects.
T9120	16616-16623	IN	denotes	Because
T9121	16638-16644	VBZ	denotes	blocks
T9122	16624-16628	NN	denotes	E2f1
T9123	16629-16637	NN	denotes	deletion
T9124	16717-16725	VBD	denotes	provided
T9125	16645-16653	JJ	denotes	abnormal
T9126	16654-16662	NN	denotes	division
T9127	16663-16666	CC	denotes	and
T9128	16667-16672	NN	denotes	death
T9129	16673-16675	IN	denotes	in
T9130	16676-16679	DT	denotes	the
T9131	16686-16692	NN	denotes	retina
T9132	16680-16682	NN	denotes	Rb
T9133	16683-16685	NN	denotes	KO
T9134	16692-16694	,	denotes	,
T9135	16694-16697	DT	denotes	the
T9136	16710-16716	NN	denotes	retina
T9137	16698-16700	NN	denotes	Rb
T9138	16701-16705	NN	denotes	E2f1
T9139	16700-16701	HYPH	denotes	/
T9140	16706-16709	NN	denotes	DKO
T9141	16726-16727	DT	denotes	a
T9142	16735-16746	NN	denotes	opportunity
T9143	16728-16734	JJ	denotes	unique
T9144	16747-16749	TO	denotes	to
T9145	16750-16758	VB	denotes	evaluate
T9146	16759-16766	IN	denotes	whether
T9147	16770-16778	VBZ	denotes	controls
T9148	16767-16769	NN	denotes	Rb
T9149	16779-16794	NN	denotes	differentiation
T9150	16795-16806	JJ	denotes	independent
T9151	16807-16809	IN	denotes	of
T9152	16810-16814	NN	denotes	cell
T9153	16815-16820	NN	denotes	cycle
T9154	16821-16828	NNS	denotes	effects
T9155	16828-16829	.	denotes	.
T9156	16829-16998	sentence	denotes	The Rb/E2f1 DKO retina had many Sag+ (S-antigen/rod arrestin) photoreceptors, Pou4f2+ (Brn3b) ganglion cells, and numerous Prkca+/Cabp5+ bipolar neurons (Figure 2A–2D).
T9157	16830-16833	DT	denotes	The
T9158	16846-16852	NN	denotes	retina
T9159	16834-16836	NN	denotes	Rb
T9160	16837-16841	NN	denotes	E2f1
T9161	16836-16837	HYPH	denotes	/
T9162	16842-16845	NN	denotes	DKO
T9163	16853-16856	VBD	denotes	had
T9164	16857-16861	JJ	denotes	many
T9165	16892-16906	NNS	denotes	photoreceptors
T9166	16862-16865	NN	denotes	Sag
T9167	16865-16866	SYM	denotes	+
T9168	16867-16868	-LRB-	denotes	(
T9169	16868-16869	NN	denotes	S
T9170	16882-16890	NN	denotes	arrestin
T9171	16869-16870	HYPH	denotes	-
T9172	16870-16877	NN	denotes	antigen
T9173	16877-16878	HYPH	denotes	/
T9174	16878-16881	NN	denotes	rod
T9175	16890-16891	-RRB-	denotes	)
T9176	16906-16908	,	denotes	,
T9177	16908-16914	NN	denotes	Pou4f2
T9178	16933-16938	NNS	denotes	cells
T9179	16914-16915	SYM	denotes	+
T9180	16916-16917	-LRB-	denotes	(
T9181	16917-16922	NN	denotes	Brn3b
T9182	16922-16923	-RRB-	denotes	)
T9183	16924-16932	NN	denotes	ganglion
T9184	16938-16940	,	denotes	,
T9185	16940-16943	CC	denotes	and
T9186	16944-16952	JJ	denotes	numerous
T9187	16975-16982	NNS	denotes	neurons
T9188	16953-16958	NN	denotes	Prkca
T9189	16958-16959	SYM	denotes	+
T9190	16959-16960	HYPH	denotes	/
T9191	16960-16965	NN	denotes	Cabp5
T9192	16965-16966	SYM	denotes	+
T9193	16967-16974	JJ	denotes	bipolar
T9194	16983-16984	-LRB-	denotes	(
T9195	16991-16993	NN	denotes	2A
T9196	16984-16990	NN	denotes	Figure
T9197	16993-16994	SYM	denotes	–
T9198	16994-16996	NN	denotes	2D
T9199	16996-16997	-RRB-	denotes	)
T9200	16997-16998	.	denotes	.
T9201	16998-17097	sentence	denotes	In contrast, there was no such rescue of cell types in Rb/E2f2 or Rb/E2f3 DKO retinas (Figure S4).
T9202	16999-17001	IN	denotes	In
T9203	17018-17021	VBD	denotes	was
T9204	17002-17010	NN	denotes	contrast
T9205	17010-17012	,	denotes	,
T9206	17012-17017	EX	denotes	there
T9207	17022-17024	DT	denotes	no
T9208	17030-17036	NN	denotes	rescue
T9209	17025-17029	JJ	denotes	such
T9210	17037-17039	IN	denotes	of
T9211	17040-17044	NN	denotes	cell
T9212	17045-17050	NNS	denotes	types
T9213	17051-17053	IN	denotes	in
T9214	17054-17056	NN	denotes	Rb
T9215	17057-17061	NN	denotes	E2f2
T9216	17056-17057	SYM	denotes	/
T9217	17073-17076	NN	denotes	DKO
T9218	17062-17064	CC	denotes	or
T9219	17065-17067	NN	denotes	Rb
T9220	17068-17072	NN	denotes	E2f3
T9221	17067-17068	SYM	denotes	/
T9222	17077-17084	NNS	denotes	retinas
T9223	17085-17086	-LRB-	denotes	(
T9224	17093-17095	NN	denotes	S4
T9225	17086-17092	NN	denotes	Figure
T9226	17095-17096	-RRB-	denotes	)
T9227	17096-17097	.	denotes	.
T9228	17097-17347	sentence	denotes	Analysis with general neuronal markers Mtap2 (MAP2) and Snap25, as well as other markers expressed in bipolar cells (Chx10, Rcvrn, Vsx1, Tacr3, and Atp2b1) and rod photoreceptors (Rho and Rcvrn) confirmed rescue of the Rb/E2f1 DKO retina (Table S1).
T9229	17098-17106	NN	denotes	Analysis
T9230	17293-17302	VBD	denotes	confirmed
T9231	17107-17111	IN	denotes	with
T9232	17112-17119	JJ	denotes	general
T9233	17137-17142	NN	denotes	Mtap2
T9234	17120-17128	JJ	denotes	neuronal
T9235	17129-17136	NNS	denotes	markers
T9236	17143-17144	-LRB-	denotes	(
T9237	17144-17148	NN	denotes	MAP2
T9238	17148-17149	-RRB-	denotes	)
T9239	17150-17153	CC	denotes	and
T9240	17154-17160	NN	denotes	Snap25
T9241	17160-17162	,	denotes	,
T9242	17162-17164	RB	denotes	as
T9243	17170-17172	IN	denotes	as
T9244	17165-17169	RB	denotes	well
T9245	17173-17178	JJ	denotes	other
T9246	17179-17186	NNS	denotes	markers
T9247	17187-17196	VBN	denotes	expressed
T9248	17197-17199	IN	denotes	in
T9249	17200-17207	JJ	denotes	bipolar
T9250	17208-17213	NNS	denotes	cells
T9251	17214-17215	-LRB-	denotes	(
T9252	17215-17220	NN	denotes	Chx10
T9253	17220-17222	,	denotes	,
T9254	17222-17227	NN	denotes	Rcvrn
T9255	17227-17229	,	denotes	,
T9256	17229-17233	NN	denotes	Vsx1
T9257	17233-17235	,	denotes	,
T9258	17235-17240	NN	denotes	Tacr3
T9259	17240-17242	,	denotes	,
T9260	17242-17245	CC	denotes	and
T9261	17246-17252	NN	denotes	Atp2b1
T9262	17252-17253	-RRB-	denotes	)
T9263	17254-17257	CC	denotes	and
T9264	17258-17261	NN	denotes	rod
T9265	17262-17276	NNS	denotes	photoreceptors
T9266	17277-17278	-LRB-	denotes	(
T9267	17278-17281	NN	denotes	Rho
T9268	17282-17285	CC	denotes	and
T9269	17286-17291	NN	denotes	Rcvrn
T9270	17291-17292	-RRB-	denotes	)
T9271	17303-17309	NN	denotes	rescue
T9272	17310-17312	IN	denotes	of
T9273	17313-17316	DT	denotes	the
T9274	17329-17335	NN	denotes	retina
T9275	17317-17319	NN	denotes	Rb
T9276	17320-17324	NN	denotes	E2f1
T9277	17319-17320	HYPH	denotes	/
T9278	17325-17328	NN	denotes	DKO
T9279	17336-17337	-LRB-	denotes	(
T9280	17343-17345	NN	denotes	S1
T9281	17337-17342	NN	denotes	Table
T9282	17345-17346	-RRB-	denotes	)
T9283	17346-17347	.	denotes	.
T9284	17347-17420	sentence	denotes	Moreover, neurons exhibited the same complex morphology as in WT retina.
T9285	17348-17356	RB	denotes	Moreover
T9286	17366-17375	VBD	denotes	exhibited
T9287	17356-17358	,	denotes	,
T9288	17358-17365	NNS	denotes	neurons
T9289	17376-17379	DT	denotes	the
T9290	17393-17403	NN	denotes	morphology
T9291	17380-17384	JJ	denotes	same
T9292	17385-17392	NN	denotes	complex
T9293	17404-17406	IN	denotes	as
T9294	17407-17409	IN	denotes	in
T9295	17410-17412	NN	denotes	WT
T9296	17413-17419	NN	denotes	retina
T9297	17419-17420	.	denotes	.
T9298	17420-17560	sentence	denotes	Bipolar cell bodies were located in the INL and had ascending and descending processes ending in the OPL and IPL, respectively (Figure 2A).
T9299	17421-17428	JJ	denotes	Bipolar
T9300	17434-17440	NNS	denotes	bodies
T9301	17429-17433	NN	denotes	cell
T9302	17446-17453	VBN	denotes	located
T9303	17441-17445	VBD	denotes	were
T9304	17454-17456	IN	denotes	in
T9305	17457-17460	DT	denotes	the
T9306	17461-17464	NN	denotes	INL
T9307	17465-17468	CC	denotes	and
T9308	17469-17472	VBD	denotes	had
T9309	17473-17482	VBG	denotes	ascending
T9310	17498-17507	NNS	denotes	processes
T9311	17483-17486	CC	denotes	and
T9312	17487-17497	VBG	denotes	descending
T9313	17508-17514	VBG	denotes	ending
T9314	17515-17517	IN	denotes	in
T9315	17518-17521	DT	denotes	the
T9316	17522-17525	NN	denotes	OPL
T9317	17526-17529	CC	denotes	and
T9318	17530-17533	NN	denotes	IPL
T9319	17533-17535	,	denotes	,
T9320	17535-17547	RB	denotes	respectively
T9321	17548-17549	-LRB-	denotes	(
T9322	17556-17558	NN	denotes	2A
T9323	17549-17555	NN	denotes	Figure
T9324	17558-17559	-RRB-	denotes	)
T9325	17559-17560	.	denotes	.
T9326	17560-17791	sentence	denotes	In addition, the Rb/E2f1 DKO retina had a healthy appearing ONL consisting of morphologically normal rods with descending processes ending in the OPL and ascending processes that terminated in inner and outer segments (Figure 2A).
T9327	17561-17563	IN	denotes	In
T9328	17597-17600	VBD	denotes	had
T9329	17564-17572	NN	denotes	addition
T9330	17572-17574	,	denotes	,
T9331	17574-17577	DT	denotes	the
T9332	17590-17596	NN	denotes	retina
T9333	17578-17580	NN	denotes	Rb
T9334	17581-17585	NN	denotes	E2f1
T9335	17580-17581	HYPH	denotes	/
T9336	17586-17589	NN	denotes	DKO
T9337	17601-17602	DT	denotes	a
T9338	17621-17624	NN	denotes	ONL
T9339	17603-17610	JJ	denotes	healthy
T9340	17611-17620	VBG	denotes	appearing
T9341	17625-17635	VBG	denotes	consisting
T9342	17636-17638	IN	denotes	of
T9343	17639-17654	RB	denotes	morphologically
T9344	17655-17661	JJ	denotes	normal
T9345	17662-17666	NNS	denotes	rods
T9346	17667-17671	IN	denotes	with
T9347	17672-17682	VBG	denotes	descending
T9348	17683-17692	NNS	denotes	processes
T9349	17693-17699	VBG	denotes	ending
T9350	17700-17702	IN	denotes	in
T9351	17703-17706	DT	denotes	the
T9352	17707-17710	NN	denotes	OPL
T9353	17711-17714	CC	denotes	and
T9354	17715-17724	VBG	denotes	ascending
T9355	17725-17734	NNS	denotes	processes
T9356	17735-17739	WDT	denotes	that
T9357	17740-17750	VBD	denotes	terminated
T9358	17751-17753	IN	denotes	in
T9359	17754-17759	JJ	denotes	inner
T9360	17770-17778	NNS	denotes	segments
T9361	17760-17763	CC	denotes	and
T9362	17764-17769	JJ	denotes	outer
T9363	17779-17780	-LRB-	denotes	(
T9364	17787-17789	NN	denotes	2A
T9365	17780-17786	NN	denotes	Figure
T9366	17789-17790	-RRB-	denotes	)
T9367	17790-17791	.	denotes	.
T9368	17791-17932	sentence	denotes	It was suggested that Rb might regulate photoreceptor differentiation, possibly through rod-specific transcription factors (Figure 1B) [29].
T9369	17792-17794	PRP	denotes	It
T9370	17799-17808	VBN	denotes	suggested
T9371	17795-17798	VBD	denotes	was
T9372	17809-17813	IN	denotes	that
T9373	17823-17831	VB	denotes	regulate
T9374	17814-17816	NN	denotes	Rb
T9375	17817-17822	MD	denotes	might
T9376	17832-17845	NN	denotes	photoreceptor
T9377	17846-17861	NN	denotes	differentiation
T9378	17861-17863	,	denotes	,
T9379	17863-17871	RB	denotes	possibly
T9380	17872-17879	IN	denotes	through
T9381	17880-17883	NN	denotes	rod
T9382	17884-17892	JJ	denotes	specific
T9383	17883-17884	HYPH	denotes	-
T9384	17907-17914	NNS	denotes	factors
T9385	17893-17906	NN	denotes	transcription
T9386	17915-17916	-LRB-	denotes	(
T9387	17923-17925	NN	denotes	1B
T9388	17916-17922	NN	denotes	Figure
T9389	17925-17926	-RRB-	denotes	)
T9390	17927-17928	-LRB-	denotes	[
T9391	17928-17930	CD	denotes	29
T9392	17930-17931	-RRB-	denotes	]
T9393	17931-17932	.	denotes	.
T9394	17932-18099	sentence	denotes	However, if Rb does regulate photoreceptor differentiation, it does so by inhibiting E2f1, not by potentiating rod differentiation factors, such as Otx2, Crx, or Nrl.
T9395	17933-17940	RB	denotes	However
T9396	17996-18000	VBZ	denotes	does
T9397	17940-17942	,	denotes	,
T9398	17942-17944	IN	denotes	if
T9399	17953-17961	VB	denotes	regulate
T9400	17945-17947	NN	denotes	Rb
T9401	17948-17952	VBZ	denotes	does
T9402	17962-17975	NN	denotes	photoreceptor
T9403	17976-17991	NN	denotes	differentiation
T9404	17991-17993	,	denotes	,
T9405	17993-17995	PRP	denotes	it
T9406	18001-18003	RB	denotes	so
T9407	18004-18006	IN	denotes	by
T9408	18007-18017	VBG	denotes	inhibiting
T9409	18018-18022	NN	denotes	E2f1
T9410	18022-18024	,	denotes	,
T9411	18024-18027	CC	denotes	not
T9412	18028-18030	IN	denotes	by
T9413	18031-18043	VBG	denotes	potentiating
T9414	18044-18047	NN	denotes	rod
T9415	18048-18063	NN	denotes	differentiation
T9416	18064-18071	NNS	denotes	factors
T9417	18071-18073	,	denotes	,
T9418	18073-18077	JJ	denotes	such
T9419	18078-18080	IN	denotes	as
T9420	18081-18085	NN	denotes	Otx2
T9421	18085-18087	,	denotes	,
T9422	18087-18090	NN	denotes	Crx
T9423	18090-18092	,	denotes	,
T9424	18092-18094	CC	denotes	or
T9425	18095-18098	NN	denotes	Nrl
T9426	18098-18099	.	denotes	.
T9427	18099-18316	sentence	denotes	It is impossible to tell whether E2f1 perturbs differentiation directly, by affecting the expression of genes that modulate maturation, and/or indirectly through its effects on proliferation and survival (Figure 1B).
T9428	18100-18102	PRP	denotes	It
T9429	18103-18105	VBZ	denotes	is
T9430	18106-18116	JJ	denotes	impossible
T9431	18117-18119	TO	denotes	to
T9432	18120-18124	VB	denotes	tell
T9433	18125-18132	IN	denotes	whether
T9434	18138-18146	NNS	denotes	perturbs
T9435	18133-18137	NN	denotes	E2f1
T9436	18147-18162	NN	denotes	differentiation
T9437	18163-18171	RB	denotes	directly
T9438	18171-18173	,	denotes	,
T9439	18173-18175	IN	denotes	by
T9440	18176-18185	VBG	denotes	affecting
T9441	18186-18189	DT	denotes	the
T9442	18190-18200	NN	denotes	expression
T9443	18201-18203	IN	denotes	of
T9444	18204-18209	NNS	denotes	genes
T9445	18210-18214	WDT	denotes	that
T9446	18215-18223	VBP	denotes	modulate
T9447	18224-18234	NN	denotes	maturation
T9448	18234-18236	,	denotes	,
T9449	18236-18239	CC	denotes	and
T9450	18239-18240	HYPH	denotes	/
T9451	18240-18242	CC	denotes	or
T9452	18243-18253	RB	denotes	indirectly
T9453	18312-18314	NN	denotes	1B
T9454	18254-18261	IN	denotes	through
T9455	18262-18265	PRP$	denotes	its
T9456	18266-18273	NNS	denotes	effects
T9457	18274-18276	IN	denotes	on
T9458	18277-18290	NN	denotes	proliferation
T9459	18291-18294	CC	denotes	and
T9460	18295-18303	NN	denotes	survival
T9461	18304-18305	-LRB-	denotes	(
T9462	18305-18311	NN	denotes	Figure
T9463	18314-18315	-RRB-	denotes	)
T9464	18315-18316	.	denotes	.
T9465	18316-18479	sentence	denotes	As with ectopic division and apoptosis (Figure 1C and 1D), the rescue of Rb KO retinal bipolar, ganglion, and rod cells was dependent on E2f1 dose (Figure 2A–2D).
T9466	18317-18319	IN	denotes	As
T9467	18437-18440	VBD	denotes	was
T9468	18320-18324	IN	denotes	with
T9469	18325-18332	JJ	denotes	ectopic
T9470	18333-18341	NN	denotes	division
T9471	18342-18345	CC	denotes	and
T9472	18346-18355	NN	denotes	apoptosis
T9473	18356-18357	-LRB-	denotes	(
T9474	18364-18366	NN	denotes	1C
T9475	18357-18363	NN	denotes	Figure
T9476	18367-18370	CC	denotes	and
T9477	18371-18373	NN	denotes	1D
T9478	18373-18374	-RRB-	denotes	)
T9479	18374-18376	,	denotes	,
T9480	18376-18379	DT	denotes	the
T9481	18380-18386	NN	denotes	rescue
T9482	18387-18389	IN	denotes	of
T9483	18390-18392	NN	denotes	Rb
T9484	18393-18395	NN	denotes	KO
T9485	18431-18436	NNS	denotes	cells
T9486	18396-18403	NN	denotes	retinal
T9487	18404-18411	JJ	denotes	bipolar
T9488	18411-18413	,	denotes	,
T9489	18413-18421	NN	denotes	ganglion
T9490	18421-18423	,	denotes	,
T9491	18423-18426	CC	denotes	and
T9492	18427-18430	NN	denotes	rod
T9493	18441-18450	JJ	denotes	dependent
T9494	18451-18453	IN	denotes	on
T9495	18454-18458	NN	denotes	E2f1
T9496	18459-18463	NN	denotes	dose
T9497	18464-18465	-LRB-	denotes	(
T9498	18472-18474	NN	denotes	2A
T9499	18465-18471	NN	denotes	Figure
T9500	18474-18475	SYM	denotes	–
T9501	18475-18477	NN	denotes	2D
T9502	18477-18478	-RRB-	denotes	)
T9503	18478-18479	.	denotes	.
T9504	18479-18674	sentence	denotes	Separate from its role in driving ectopic division of Rb KO RTCs, E2f1 also promotes normal RPC division since in its absence RPC proliferation drops ~2-fold (D. C. and R. B., unpublished data).
T9505	18480-18488	JJ	denotes	Separate
T9506	18556-18564	VBZ	denotes	promotes
T9507	18489-18493	IN	denotes	from
T9508	18494-18497	PRP$	denotes	its
T9509	18498-18502	NN	denotes	role
T9510	18503-18505	IN	denotes	in
T9511	18506-18513	VBG	denotes	driving
T9512	18514-18521	JJ	denotes	ectopic
T9513	18522-18530	NN	denotes	division
T9514	18531-18533	IN	denotes	of
T9515	18534-18536	NN	denotes	Rb
T9516	18537-18539	NN	denotes	KO
T9517	18540-18544	NNS	denotes	RTCs
T9518	18544-18546	,	denotes	,
T9519	18546-18550	NN	denotes	E2f1
T9520	18551-18555	RB	denotes	also
T9521	18565-18571	JJ	denotes	normal
T9522	18576-18584	NN	denotes	division
T9523	18572-18575	NN	denotes	RPC
T9524	18585-18590	IN	denotes	since
T9525	18624-18629	VBZ	denotes	drops
T9526	18591-18593	IN	denotes	in
T9527	18594-18597	PRP$	denotes	its
T9528	18598-18605	NN	denotes	absence
T9529	18606-18609	NN	denotes	RPC
T9530	18610-18623	NN	denotes	proliferation
T9531	18630-18631	SYM	denotes	~
T9532	18631-18632	CD	denotes	2
T9533	18632-18633	HYPH	denotes	-
T9534	18633-18637	RB	denotes	fold
T9535	18638-18639	-LRB-	denotes	(
T9536	18639-18641	NNP	denotes	D.
T9537	18642-18644	NNP	denotes	C.
T9538	18645-18648	CC	denotes	and
T9539	18649-18651	NNP	denotes	R.
T9540	18652-18654	NNP	denotes	B.
T9541	18654-18656	,	denotes	,
T9542	18656-18667	JJ	denotes	unpublished
T9543	18668-18672	NNS	denotes	data
T9544	18672-18673	-RRB-	denotes	)
T9545	18673-18674	.	denotes	.
T9546	18674-18953	sentence	denotes	This modest reduction of RPC numbers in the absence of E2f1 accounts for the slight reduction in the number of ganglion cells at P0, in the number of bipolar cells at P18 or P30, and in the thickness of the ONL at P18 or P30 in the E2f1 KO and Rb/E2f1 DKO retina (Figure 2B–2D).
T9547	18675-18679	DT	denotes	This
T9548	18687-18696	NN	denotes	reduction
T9549	18680-18686	JJ	denotes	modest
T9550	18735-18743	VBZ	denotes	accounts
T9551	18697-18699	IN	denotes	of
T9552	18700-18703	NN	denotes	RPC
T9553	18704-18711	NNS	denotes	numbers
T9554	18712-18714	IN	denotes	in
T9555	18715-18718	DT	denotes	the
T9556	18719-18726	NN	denotes	absence
T9557	18727-18729	IN	denotes	of
T9558	18730-18734	NN	denotes	E2f1
T9559	18744-18747	IN	denotes	for
T9560	18748-18751	DT	denotes	the
T9561	18759-18768	NN	denotes	reduction
T9562	18752-18758	JJ	denotes	slight
T9563	18769-18771	IN	denotes	in
T9564	18772-18775	DT	denotes	the
T9565	18776-18782	NN	denotes	number
T9566	18783-18785	IN	denotes	of
T9567	18786-18794	NN	denotes	ganglion
T9568	18795-18800	NNS	denotes	cells
T9569	18801-18803	IN	denotes	at
T9570	18804-18806	NN	denotes	P0
T9571	18806-18808	,	denotes	,
T9572	18808-18810	IN	denotes	in
T9573	18811-18814	DT	denotes	the
T9574	18815-18821	NN	denotes	number
T9575	18822-18824	IN	denotes	of
T9576	18825-18832	JJ	denotes	bipolar
T9577	18833-18838	NNS	denotes	cells
T9578	18839-18841	IN	denotes	at
T9579	18842-18845	NN	denotes	P18
T9580	18846-18848	CC	denotes	or
T9581	18849-18852	NN	denotes	P30
T9582	18852-18854	,	denotes	,
T9583	18854-18857	CC	denotes	and
T9584	18858-18860	IN	denotes	in
T9585	18861-18864	DT	denotes	the
T9586	18865-18874	NN	denotes	thickness
T9587	18875-18877	IN	denotes	of
T9588	18878-18881	DT	denotes	the
T9589	18882-18885	NN	denotes	ONL
T9590	18886-18888	IN	denotes	at
T9591	18889-18892	NN	denotes	P18
T9592	18893-18895	CC	denotes	or
T9593	18896-18899	NN	denotes	P30
T9594	18900-18902	IN	denotes	in
T9595	18903-18906	DT	denotes	the
T9596	18931-18937	NN	denotes	retina
T9597	18907-18911	NN	denotes	E2f1
T9598	18912-18914	NN	denotes	KO
T9599	18915-18918	CC	denotes	and
T9600	18919-18921	NN	denotes	Rb
T9601	18922-18926	NN	denotes	E2f1
T9602	18921-18922	HYPH	denotes	/
T9603	18927-18930	NN	denotes	DKO
T9604	18938-18939	-LRB-	denotes	(
T9605	18946-18948	NN	denotes	2B
T9606	18939-18945	NN	denotes	Figure
T9607	18948-18949	SYM	denotes	–
T9608	18949-18951	NN	denotes	2D
T9609	18951-18952	-RRB-	denotes	)
T9610	18952-18953	.	denotes	.
T9611	18953-19007	sentence	denotes	The morphology of E2f1 KO neurons was WT (Figure 2A).
T9612	18954-18957	DT	denotes	The
T9613	18958-18968	NN	denotes	morphology
T9614	18988-18991	VBD	denotes	was
T9615	18969-18971	IN	denotes	of
T9616	18972-18976	NN	denotes	E2f1
T9617	18977-18979	NN	denotes	KO
T9618	18980-18987	NNS	denotes	neurons
T9619	18992-18994	NN	denotes	WT
T9620	18995-18996	-LRB-	denotes	(
T9621	19003-19005	NN	denotes	2A
T9622	18996-19002	NN	denotes	Figure
T9623	19005-19006	-RRB-	denotes	)
T9624	19006-19007	.	denotes	.
T9625	19007-19148	sentence	denotes	Despite a slight drop in absolute cell numbers, the proportion of Rb/E2f1 DKO and E2f1 KO bipolar cells was the same as WT (data not shown).
T9626	19008-19015	IN	denotes	Despite
T9627	19112-19115	VBD	denotes	was
T9628	19016-19017	DT	denotes	a
T9629	19025-19029	NN	denotes	drop
T9630	19018-19024	JJ	denotes	slight
T9631	19030-19032	IN	denotes	in
T9632	19033-19041	JJ	denotes	absolute
T9633	19047-19054	NNS	denotes	numbers
T9634	19042-19046	NN	denotes	cell
T9635	19054-19056	,	denotes	,
T9636	19056-19059	DT	denotes	the
T9637	19060-19070	NN	denotes	proportion
T9638	19071-19073	IN	denotes	of
T9639	19074-19076	NN	denotes	Rb
T9640	19077-19081	NN	denotes	E2f1
T9641	19076-19077	HYPH	denotes	/
T9642	19082-19085	NN	denotes	DKO
T9643	19106-19111	NNS	denotes	cells
T9644	19086-19089	CC	denotes	and
T9645	19090-19094	NN	denotes	E2f1
T9646	19095-19097	NN	denotes	KO
T9647	19098-19105	JJ	denotes	bipolar
T9648	19116-19119	DT	denotes	the
T9649	19120-19124	JJ	denotes	same
T9650	19125-19127	IN	denotes	as
T9651	19128-19130	NN	denotes	WT
T9652	19131-19132	-LRB-	denotes	(
T9653	19141-19146	VBN	denotes	shown
T9654	19132-19136	NNS	denotes	data
T9655	19137-19140	RB	denotes	not
T9656	19146-19147	-RRB-	denotes	)
T9657	19147-19148	.	denotes	.
T9658	19148-19357	sentence	denotes	Slightly reduced cell numbers were not due to residual RTC death since we have not observed ectopic apoptosis at any embryonic or postnatal stage in the developing Rb/E2f1 DKO retina (Figures 1D, 1G, and S2).
T9659	19149-19157	RB	denotes	Slightly
T9660	19158-19165	VBN	denotes	reduced
T9661	19171-19178	NNS	denotes	numbers
T9662	19166-19170	NN	denotes	cell
T9663	19179-19183	VBD	denotes	were
T9664	19184-19187	RB	denotes	not
T9665	19188-19191	IN	denotes	due
T9666	19192-19194	IN	denotes	to
T9667	19195-19203	JJ	denotes	residual
T9668	19208-19213	NN	denotes	death
T9669	19204-19207	NN	denotes	RTC
T9670	19214-19219	IN	denotes	since
T9671	19232-19240	VBN	denotes	observed
T9672	19220-19222	PRP	denotes	we
T9673	19223-19227	VBP	denotes	have
T9674	19228-19231	RB	denotes	not
T9675	19241-19248	JJ	denotes	ectopic
T9676	19249-19258	NN	denotes	apoptosis
T9677	19259-19261	IN	denotes	at
T9678	19262-19265	DT	denotes	any
T9679	19289-19294	NN	denotes	stage
T9680	19266-19275	JJ	denotes	embryonic
T9681	19276-19278	CC	denotes	or
T9682	19279-19288	JJ	denotes	postnatal
T9683	19295-19297	IN	denotes	in
T9684	19298-19301	DT	denotes	the
T9685	19325-19331	NN	denotes	retina
T9686	19302-19312	VBG	denotes	developing
T9687	19313-19315	NN	denotes	Rb
T9688	19316-19320	NN	denotes	E2f1
T9689	19315-19316	HYPH	denotes	/
T9690	19321-19324	NN	denotes	DKO
T9691	19332-19333	-LRB-	denotes	(
T9692	19341-19343	NN	denotes	1D
T9693	19333-19340	NNS	denotes	Figures
T9694	19343-19345	,	denotes	,
T9695	19345-19347	NN	denotes	1G
T9696	19347-19349	,	denotes	,
T9697	19349-19352	CC	denotes	and
T9698	19353-19355	NN	denotes	S2
T9699	19355-19356	-RRB-	denotes	)
T9700	19356-19357	.	denotes	.
T9701	19357-19534	sentence	denotes	Moreover, deleting Ccnd1, which acts upstream of Rb proteins, also reduces RPC number, but does not suppress any defect in the Rb KO retina (D. C. and R. B., unpublished data).
T9702	19358-19366	RB	denotes	Moreover
T9703	19425-19432	VBZ	denotes	reduces
T9704	19366-19368	,	denotes	,
T9705	19368-19376	VBG	denotes	deleting
T9706	19377-19382	NN	denotes	Ccnd1
T9707	19382-19384	,	denotes	,
T9708	19384-19389	WDT	denotes	which
T9709	19390-19394	VBZ	denotes	acts
T9710	19395-19403	RB	denotes	upstream
T9711	19404-19406	IN	denotes	of
T9712	19407-19409	NN	denotes	Rb
T9713	19410-19418	NN	denotes	proteins
T9714	19418-19420	,	denotes	,
T9715	19420-19424	RB	denotes	also
T9716	19433-19436	NN	denotes	RPC
T9717	19437-19443	NN	denotes	number
T9718	19443-19445	,	denotes	,
T9719	19445-19448	CC	denotes	but
T9720	19449-19453	VBZ	denotes	does
T9721	19458-19466	VB	denotes	suppress
T9722	19454-19457	RB	denotes	not
T9723	19467-19470	DT	denotes	any
T9724	19471-19477	NN	denotes	defect
T9725	19478-19480	IN	denotes	in
T9726	19481-19484	DT	denotes	the
T9727	19491-19497	NN	denotes	retina
T9728	19485-19487	NN	denotes	Rb
T9729	19488-19490	NN	denotes	KO
T9730	19498-19499	-LRB-	denotes	(
T9731	19499-19501	NNP	denotes	D.
T9732	19502-19504	NNP	denotes	C.
T9733	19505-19508	CC	denotes	and
T9734	19509-19511	NNP	denotes	R.
T9735	19512-19514	NNP	denotes	B.
T9736	19514-19516	,	denotes	,
T9737	19516-19527	JJ	denotes	unpublished
T9738	19528-19532	NNS	denotes	data
T9739	19532-19533	-RRB-	denotes	)
T9740	19533-19534	.	denotes	.
T9741	19534-19679	sentence	denotes	Thus, slightly reduced RPC division and dramatic rescue of severe defects in Rb KO RTCs are distinct effects stemming from the deletion of E2f1.
T9742	19535-19539	RB	denotes	Thus
T9743	19623-19626	VBP	denotes	are
T9744	19539-19541	,	denotes	,
T9745	19541-19549	RB	denotes	slightly
T9746	19550-19557	JJ	denotes	reduced
T9747	19562-19570	NN	denotes	division
T9748	19558-19561	NN	denotes	RPC
T9749	19571-19574	CC	denotes	and
T9750	19575-19583	JJ	denotes	dramatic
T9751	19584-19590	NN	denotes	rescue
T9752	19591-19593	IN	denotes	of
T9753	19594-19600	JJ	denotes	severe
T9754	19601-19608	NNS	denotes	defects
T9755	19609-19611	IN	denotes	in
T9756	19612-19614	NN	denotes	Rb
T9757	19615-19617	NN	denotes	KO
T9758	19618-19622	NNS	denotes	RTCs
T9759	19627-19635	JJ	denotes	distinct
T9760	19636-19643	NNS	denotes	effects
T9761	19644-19652	VBG	denotes	stemming
T9762	19653-19657	IN	denotes	from
T9763	19658-19661	DT	denotes	the
T9764	19662-19670	NN	denotes	deletion
T9765	19671-19673	IN	denotes	of
T9766	19674-19678	NN	denotes	E2f1
T9767	19678-19679	.	denotes	.
T16893	31879-31885	NN	denotes	Figure
T11029	19681-19687	JJ	denotes	Normal
T11030	19688-19696	NN	denotes	Function
T11031	19697-19699	IN	denotes	of
T11032	19700-19703	DT	denotes	the
T11033	19716-19722	NN	denotes	Retina
T11034	19704-19706	NN	denotes	Rb
T11035	19707-19711	NN	denotes	E2f1
T11036	19706-19707	HYPH	denotes	/
T11037	19712-19715	NN	denotes	DKO
T11038	19722-19912	sentence	denotes	The discovery that E2f1 loss rescues even the morphology of Rb KO neurons is surprising because Rb is thought to regulate differentiation primarily through E2f-independent pathways [30–33].
T11039	19723-19726	DT	denotes	The
T11040	19727-19736	NN	denotes	discovery
T11041	19797-19799	VBZ	denotes	is
T11042	19737-19741	IN	denotes	that
T11043	19752-19759	VBZ	denotes	rescues
T11044	19742-19746	NN	denotes	E2f1
T11045	19747-19751	NN	denotes	loss
T11046	19760-19764	RB	denotes	even
T11047	19769-19779	NN	denotes	morphology
T11048	19765-19768	DT	denotes	the
T11049	19780-19782	IN	denotes	of
T11050	19783-19785	NN	denotes	Rb
T11051	19786-19788	NN	denotes	KO
T11052	19789-19796	NNS	denotes	neurons
T11053	19800-19810	JJ	denotes	surprising
T11054	19811-19818	IN	denotes	because
T11055	19825-19832	VBN	denotes	thought
T11056	19819-19821	NN	denotes	Rb
T11057	19822-19824	VBZ	denotes	is
T11058	19833-19835	TO	denotes	to
T11059	19836-19844	VB	denotes	regulate
T11060	19845-19860	NN	denotes	differentiation
T11061	19861-19870	RB	denotes	primarily
T11062	19871-19878	IN	denotes	through
T11063	19879-19882	NN	denotes	E2f
T11064	19883-19894	JJ	denotes	independent
T11065	19882-19883	HYPH	denotes	-
T11066	19895-19903	NNS	denotes	pathways
T11067	19904-19905	-LRB-	denotes	[
T11068	19905-19907	CD	denotes	30
T11069	19907-19908	SYM	denotes	–
T11070	19908-19910	CD	denotes	33
T11071	19910-19911	-RRB-	denotes	]
T11072	19911-19912	.	denotes	.
T11073	19912-19992	sentence	denotes	However, normal morphology may not equate to completely normal differentiation.
T11074	19913-19920	RB	denotes	However
T11075	19948-19954	VB	denotes	equate
T11076	19920-19922	,	denotes	,
T11077	19922-19928	JJ	denotes	normal
T11078	19929-19939	NN	denotes	morphology
T11079	19940-19943	MD	denotes	may
T11080	19944-19947	RB	denotes	not
T11081	19955-19957	IN	denotes	to
T11082	19958-19968	RB	denotes	completely
T11083	19969-19975	JJ	denotes	normal
T11084	19976-19991	NN	denotes	differentiation
T11085	19991-19992	.	denotes	.
T11086	19992-20125	sentence	denotes	Thus, we compared the electroretinograms (ERGs) of adult WT (α-Cre), E2f1−/−, α-Cre;RbloxP/loxP, and α-Cre;RbloxP/loxP;E2f1−/− mice.
T11087	19993-19997	RB	denotes	Thus
T11088	20002-20010	VBD	denotes	compared
T11089	19997-19999	,	denotes	,
T11090	19999-20001	PRP	denotes	we
T11091	20011-20014	DT	denotes	the
T11092	20015-20033	NNS	denotes	electroretinograms
T11093	20034-20035	-LRB-	denotes	(
T11094	20035-20039	NNS	denotes	ERGs
T11095	20039-20040	-RRB-	denotes	)
T11096	20041-20043	IN	denotes	of
T11097	20044-20049	JJ	denotes	adult
T11098	20120-20124	NNS	denotes	mice
T11099	20050-20052	NN	denotes	WT
T11100	20053-20054	-LRB-	denotes	(
T11101	20054-20055	NN	denotes	α
T11102	20056-20059	NN	denotes	Cre
T11103	20055-20056	HYPH	denotes	-
T11104	20059-20060	-RRB-	denotes	)
T11105	20060-20062	,	denotes	,
T11106	20062-20066	NN	denotes	E2f1
T11107	20066-20067	SYM	denotes	−
T11108	20067-20068	HYPH	denotes	/
T11109	20068-20069	SYM	denotes	−
T11110	20069-20071	,	denotes	,
T11111	20071-20072	NN	denotes	α
T11112	20073-20076	NN	denotes	Cre
T11113	20072-20073	HYPH	denotes	-
T11114	20076-20077	:	denotes	;
T11115	20077-20083	NN	denotes	RbloxP
T11116	20084-20088	NN	denotes	loxP
T11117	20083-20084	HYPH	denotes	/
T11118	20088-20090	,	denotes	,
T11119	20090-20093	CC	denotes	and
T11120	20094-20095	NN	denotes	α
T11121	20096-20099	NN	denotes	Cre
T11122	20095-20096	HYPH	denotes	-
T11123	20099-20100	:	denotes	;
T11124	20100-20106	NN	denotes	RbloxP
T11125	20107-20111	NN	denotes	loxP
T11126	20106-20107	HYPH	denotes	/
T11127	20111-20112	:	denotes	;
T11128	20112-20116	NN	denotes	E2f1
T11129	20116-20117	SYM	denotes	−
T11130	20117-20118	HYPH	denotes	/
T11131	20118-20119	SYM	denotes	−
T11132	20124-20125	.	denotes	.
T11133	20125-20312	sentence	denotes	ERGs functionally assess visual signalling in the mammalian retina from photoreceptors to amacrine cells (but usually not gangion cells), and are dominated by rod and cone bipolar cells.
T11134	20126-20130	NNS	denotes	ERGs
T11135	20144-20150	VBP	denotes	assess
T11136	20131-20143	RB	denotes	functionally
T11137	20151-20157	JJ	denotes	visual
T11138	20158-20168	NN	denotes	signalling
T11139	20169-20171	IN	denotes	in
T11140	20172-20175	DT	denotes	the
T11141	20186-20192	NN	denotes	retina
T11142	20176-20185	JJ	denotes	mammalian
T11143	20193-20197	IN	denotes	from
T11144	20198-20212	NNS	denotes	photoreceptors
T11145	20213-20215	IN	denotes	to
T11146	20216-20224	JJ	denotes	amacrine
T11147	20225-20230	NNS	denotes	cells
T11148	20231-20232	-LRB-	denotes	(
T11149	20232-20235	CC	denotes	but
T11150	20236-20243	RB	denotes	usually
T11151	20244-20247	RB	denotes	not
T11152	20256-20261	NNS	denotes	cells
T11153	20248-20255	NN	denotes	gangion
T11154	20261-20262	-RRB-	denotes	)
T11155	20262-20264	,	denotes	,
T11156	20264-20267	CC	denotes	and
T11157	20268-20271	VBP	denotes	are
T11158	20272-20281	VBN	denotes	dominated
T11159	20282-20284	IN	denotes	by
T11160	20285-20288	NN	denotes	rod
T11161	20306-20311	NNS	denotes	cells
T11162	20289-20292	CC	denotes	and
T11163	20293-20297	NN	denotes	cone
T11164	20298-20305	JJ	denotes	bipolar
T11165	20311-20312	.	denotes	.
T11166	20312-20524	sentence	denotes	Typically, an ERG signal begins with a negative deflection initiated by the photoreceptors (the a-wave), which is terminated by a large positive deflection due to the activation of ON bipolar cells (the b-wave).
T11167	20313-20322	RB	denotes	Typically
T11168	20338-20344	VBZ	denotes	begins
T11169	20322-20324	,	denotes	,
T11170	20324-20326	DT	denotes	an
T11171	20331-20337	NN	denotes	signal
T11172	20327-20330	NN	denotes	ERG
T11173	20345-20349	IN	denotes	with
T11174	20350-20351	DT	denotes	a
T11175	20361-20371	NN	denotes	deflection
T11176	20352-20360	JJ	denotes	negative
T11177	20372-20381	VBN	denotes	initiated
T11178	20382-20384	IN	denotes	by
T11179	20385-20388	DT	denotes	the
T11180	20389-20403	NNS	denotes	photoreceptors
T11181	20404-20405	-LRB-	denotes	(
T11182	20405-20408	DT	denotes	the
T11183	20411-20415	NN	denotes	wave
T11184	20409-20410	NN	denotes	a
T11185	20410-20411	HYPH	denotes	-
T11186	20415-20416	-RRB-	denotes	)
T11187	20416-20418	,	denotes	,
T11188	20418-20423	WDT	denotes	which
T11189	20427-20437	VBN	denotes	terminated
T11190	20424-20426	VBZ	denotes	is
T11191	20438-20440	IN	denotes	by
T11192	20441-20442	DT	denotes	a
T11193	20458-20468	NN	denotes	deflection
T11194	20443-20448	JJ	denotes	large
T11195	20449-20457	JJ	denotes	positive
T11196	20469-20472	IN	denotes	due
T11197	20473-20475	IN	denotes	to
T11198	20476-20479	DT	denotes	the
T11199	20480-20490	NN	denotes	activation
T11200	20491-20493	IN	denotes	of
T11201	20494-20496	NN	denotes	ON
T11202	20505-20510	NNS	denotes	cells
T11203	20497-20504	JJ	denotes	bipolar
T11204	20511-20512	-LRB-	denotes	(
T11205	20512-20515	DT	denotes	the
T11206	20518-20522	NN	denotes	wave
T11207	20516-20517	NN	denotes	b
T11208	20517-20518	HYPH	denotes	-
T11209	20522-20523	-RRB-	denotes	)
T11210	20523-20524	.	denotes	.
T11211	20524-20673	sentence	denotes	Responses to dim light in dark-adapted (scotopic) conditions specifically assess the rod system, and were defective in the Rb KO retina (Figure 2E).
T11212	20525-20534	NNS	denotes	Responses
T11213	20599-20605	VBP	denotes	assess
T11214	20535-20537	IN	denotes	to
T11215	20538-20541	JJ	denotes	dim
T11216	20542-20547	NN	denotes	light
T11217	20548-20550	IN	denotes	in
T11218	20551-20555	NN	denotes	dark
T11219	20556-20563	VBN	denotes	adapted
T11220	20555-20556	HYPH	denotes	-
T11221	20575-20585	NNS	denotes	conditions
T11222	20564-20565	-LRB-	denotes	(
T11223	20565-20573	JJ	denotes	scotopic
T11224	20573-20574	-RRB-	denotes	)
T11225	20586-20598	RB	denotes	specifically
T11226	20606-20609	DT	denotes	the
T11227	20614-20620	NN	denotes	system
T11228	20610-20613	NN	denotes	rod
T11229	20620-20622	,	denotes	,
T11230	20622-20625	CC	denotes	and
T11231	20626-20630	VBD	denotes	were
T11232	20631-20640	JJ	denotes	defective
T11233	20641-20643	IN	denotes	in
T11234	20644-20647	DT	denotes	the
T11235	20654-20660	NN	denotes	retina
T11236	20648-20650	NN	denotes	Rb
T11237	20651-20653	NN	denotes	KO
T11238	20661-20662	-LRB-	denotes	(
T11239	20669-20671	NN	denotes	2E
T11240	20662-20668	NN	denotes	Figure
T11241	20671-20672	-RRB-	denotes	)
T11242	20672-20673	.	denotes	.
T11243	20673-20777	sentence	denotes	The substantial reduction of both a- and b-waves is consistent with rod and bipolar cell apoptosis [2].
T11244	20674-20677	DT	denotes	The
T11245	20690-20699	NN	denotes	reduction
T11246	20678-20689	JJ	denotes	substantial
T11247	20723-20725	VBZ	denotes	is
T11248	20700-20702	IN	denotes	of
T11249	20703-20707	CC	denotes	both
T11250	20708-20709	NN	denotes	a
T11251	20717-20722	NNS	denotes	waves
T11252	20709-20710	HYPH	denotes	-
T11253	20711-20714	CC	denotes	and
T11254	20715-20716	NN	denotes	b
T11255	20716-20717	HYPH	denotes	-
T11256	20726-20736	JJ	denotes	consistent
T11257	20737-20741	IN	denotes	with
T11258	20742-20745	NN	denotes	rod
T11259	20763-20772	NN	denotes	apoptosis
T11260	20746-20749	CC	denotes	and
T11261	20750-20757	JJ	denotes	bipolar
T11262	20758-20762	NN	denotes	cell
T11263	20773-20774	-LRB-	denotes	[
T11264	20774-20775	CD	denotes	2
T11265	20775-20776	-RRB-	denotes	]
T11266	20776-20777	.	denotes	.
T11267	20777-20904	sentence	denotes	The sensitivity of the residual response appeared unchanged, suggesting it arose from the Cre-negative portions of the retina.
T11268	20778-20781	DT	denotes	The
T11269	20782-20793	NN	denotes	sensitivity
T11270	20819-20827	VBD	denotes	appeared
T11271	20794-20796	IN	denotes	of
T11272	20797-20800	DT	denotes	the
T11273	20810-20818	NN	denotes	response
T11274	20801-20809	JJ	denotes	residual
T11275	20828-20837	JJ	denotes	unchanged
T11276	20837-20839	,	denotes	,
T11277	20839-20849	VBG	denotes	suggesting
T11278	20850-20852	PRP	denotes	it
T11279	20853-20858	VBD	denotes	arose
T11280	20859-20863	IN	denotes	from
T11281	20864-20867	DT	denotes	the
T11282	20881-20889	NNS	denotes	portions
T11283	20868-20871	NN	denotes	Cre
T11284	20872-20880	JJ	denotes	negative
T11285	20871-20872	HYPH	denotes	-
T11286	20890-20892	IN	denotes	of
T11287	20893-20896	DT	denotes	the
T11288	20897-20903	NN	denotes	retina
T11289	20903-20904	.	denotes	.
T11290	20904-21099	sentence	denotes	Responses were about the same in the WT and E2f1 KO retina, and, most importantly, also the Rb/E2f1 DKO response median lay at the lower end of the normal range for most intensities (Figure 2F).
T11291	20905-20914	NNS	denotes	Responses
T11292	20915-20919	VBD	denotes	were
T11293	20920-20925	RB	denotes	about
T11294	20930-20934	JJ	denotes	same
T11295	20926-20929	DT	denotes	the
T11296	20935-20937	IN	denotes	in
T11297	20938-20941	DT	denotes	the
T11298	20957-20963	NN	denotes	retina
T11299	20942-20944	NN	denotes	WT
T11300	20945-20948	CC	denotes	and
T11301	20949-20953	NN	denotes	E2f1
T11302	20954-20956	NN	denotes	KO
T11303	20963-20965	,	denotes	,
T11304	20965-20968	CC	denotes	and
T11305	20968-20970	,	denotes	,
T11306	20970-20974	RBS	denotes	most
T11307	20975-20986	RB	denotes	importantly
T11308	21025-21028	VBD	denotes	lay
T11309	20986-20988	,	denotes	,
T11310	20988-20992	RB	denotes	also
T11311	20993-20996	DT	denotes	the
T11312	21009-21017	NN	denotes	response
T11313	20997-20999	NN	denotes	Rb
T11314	21000-21004	NN	denotes	E2f1
T11315	20999-21000	HYPH	denotes	/
T11316	21005-21008	NN	denotes	DKO
T11317	21018-21024	JJ	denotes	median
T11318	21029-21031	IN	denotes	at
T11319	21032-21035	DT	denotes	the
T11320	21042-21045	NN	denotes	end
T11321	21036-21041	JJ	denotes	lower
T11322	21046-21048	IN	denotes	of
T11323	21049-21052	DT	denotes	the
T11324	21060-21065	NN	denotes	range
T11325	21053-21059	JJ	denotes	normal
T11326	21066-21069	IN	denotes	for
T11327	21070-21074	JJS	denotes	most
T11328	21075-21086	NNS	denotes	intensities
T11329	21087-21088	-LRB-	denotes	(
T11330	21095-21097	NN	denotes	2F
T11331	21088-21094	NN	denotes	Figure
T11332	21097-21098	-RRB-	denotes	)
T11333	21098-21099	.	denotes	.
T11334	21099-21181	sentence	denotes	Thus, E2f1 deletion almost completely rescued the rod system in the Rb KO retina.
T11335	21100-21104	RB	denotes	Thus
T11336	21138-21145	VBD	denotes	rescued
T11337	21104-21106	,	denotes	,
T11338	21106-21110	NN	denotes	E2f1
T11339	21111-21119	NN	denotes	deletion
T11340	21120-21126	RB	denotes	almost
T11341	21127-21137	RB	denotes	completely
T11342	21146-21149	DT	denotes	the
T11343	21154-21160	NN	denotes	system
T11344	21150-21153	NN	denotes	rod
T11345	21161-21163	IN	denotes	in
T11346	21164-21167	DT	denotes	the
T11347	21174-21180	NN	denotes	retina
T11348	21168-21170	NN	denotes	Rb
T11349	21171-21173	NN	denotes	KO
T11350	21180-21181	.	denotes	.
T11351	21181-21284	sentence	denotes	Light-adapted (photopic) recordings to specifically assess the cone system yielded comparable results.
T11352	21182-21187	NN	denotes	Light
T11353	21188-21195	VBN	denotes	adapted
T11354	21187-21188	HYPH	denotes	-
T11355	21207-21217	NNS	denotes	recordings
T11356	21196-21197	-LRB-	denotes	(
T11357	21197-21205	JJ	denotes	photopic
T11358	21205-21206	-RRB-	denotes	)
T11359	21257-21264	VBD	denotes	yielded
T11360	21218-21220	TO	denotes	to
T11361	21234-21240	VB	denotes	assess
T11362	21221-21233	RB	denotes	specifically
T11363	21241-21244	DT	denotes	the
T11364	21250-21256	NN	denotes	system
T11365	21245-21249	NN	denotes	cone
T11366	21265-21275	JJ	denotes	comparable
T11367	21276-21283	NNS	denotes	results
T11368	21283-21284	.	denotes	.
T11369	21284-21521	sentence	denotes	Cones represent only 3% of photoreceptors and, unlike rods, develop without Rb, but they require rods for survival, and in the Rb KO retina, they have abnormal morphology and their synaptic targets, bipolar cells, are much depleted [2].
T11370	21285-21290	NNS	denotes	Cones
T11371	21291-21300	VBP	denotes	represent
T11372	21301-21305	RB	denotes	only
T11373	21306-21307	CD	denotes	3
T11374	21307-21308	NN	denotes	%
T11375	21309-21311	IN	denotes	of
T11376	21312-21326	NNS	denotes	photoreceptors
T11377	21327-21330	CC	denotes	and
T11378	21330-21332	,	denotes	,
T11379	21332-21338	JJ	denotes	unlike
T11380	21345-21352	VBP	denotes	develop
T11381	21339-21343	NNS	denotes	rods
T11382	21343-21345	,	denotes	,
T11383	21353-21360	IN	denotes	without
T11384	21361-21363	NN	denotes	Rb
T11385	21363-21365	,	denotes	,
T11386	21365-21368	CC	denotes	but
T11387	21369-21373	PRP	denotes	they
T11388	21374-21381	VBP	denotes	require
T11389	21382-21386	NNS	denotes	rods
T11390	21387-21390	IN	denotes	for
T11391	21391-21399	NN	denotes	survival
T11392	21399-21401	,	denotes	,
T11393	21401-21404	CC	denotes	and
T11394	21405-21407	IN	denotes	in
T11395	21431-21435	VBP	denotes	have
T11396	21408-21411	DT	denotes	the
T11397	21418-21424	NN	denotes	retina
T11398	21412-21414	NN	denotes	Rb
T11399	21415-21417	NN	denotes	KO
T11400	21424-21426	,	denotes	,
T11401	21426-21430	PRP	denotes	they
T11402	21436-21444	JJ	denotes	abnormal
T11403	21445-21455	NN	denotes	morphology
T11404	21456-21459	CC	denotes	and
T11405	21460-21465	PRP$	denotes	their
T11406	21475-21482	NNS	denotes	targets
T11407	21466-21474	JJ	denotes	synaptic
T11408	21499-21502	VBP	denotes	are
T11409	21482-21484	,	denotes	,
T11410	21484-21491	JJ	denotes	bipolar
T11411	21492-21497	NNS	denotes	cells
T11412	21497-21499	,	denotes	,
T11413	21503-21507	RB	denotes	much
T11414	21508-21516	JJ	denotes	depleted
T11415	21517-21518	-LRB-	denotes	[
T11416	21518-21519	CD	denotes	2
T11417	21519-21520	-RRB-	denotes	]
T11418	21520-21521	.	denotes	.
T11419	21521-21688	sentence	denotes	The photopic response, a product of cone and mainly bipolar activity, was much reduced by Rb loss, but was rescued considerably in the Rb/E2f1 DKO retina (Figure S5).
T11420	21522-21525	DT	denotes	The
T11421	21535-21543	NN	denotes	response
T11422	21526-21534	JJ	denotes	photopic
T11423	21601-21608	VBN	denotes	reduced
T11424	21543-21545	,	denotes	,
T11425	21545-21546	DT	denotes	a
T11426	21547-21554	NN	denotes	product
T11427	21555-21557	IN	denotes	of
T11428	21558-21562	NN	denotes	cone
T11429	21582-21590	NN	denotes	activity
T11430	21563-21566	CC	denotes	and
T11431	21567-21573	RB	denotes	mainly
T11432	21574-21581	JJ	denotes	bipolar
T11433	21590-21592	,	denotes	,
T11434	21592-21595	VBD	denotes	was
T11435	21596-21600	RB	denotes	much
T11436	21609-21611	IN	denotes	by
T11437	21612-21614	NN	denotes	Rb
T11438	21615-21619	NN	denotes	loss
T11439	21619-21621	,	denotes	,
T11440	21621-21624	CC	denotes	but
T11441	21625-21628	VBD	denotes	was
T11442	21629-21636	VBN	denotes	rescued
T11443	21637-21649	RB	denotes	considerably
T11444	21650-21652	IN	denotes	in
T11445	21653-21656	DT	denotes	the
T11446	21669-21675	NN	denotes	retina
T11447	21657-21659	NN	denotes	Rb
T11448	21660-21664	NN	denotes	E2f1
T11449	21659-21660	HYPH	denotes	/
T11450	21665-21668	NN	denotes	DKO
T11451	21676-21677	-LRB-	denotes	(
T11452	21684-21686	NN	denotes	S5
T11453	21677-21683	NN	denotes	Figure
T11454	21686-21687	-RRB-	denotes	)
T11455	21687-21688	.	denotes	.
T11456	21688-21759	sentence	denotes	Again, the median amplitude lay at the lower end of the E2f1 KO range.
T11457	21689-21694	RB	denotes	Again
T11458	21717-21720	VBD	denotes	lay
T11459	21694-21696	,	denotes	,
T11460	21696-21699	DT	denotes	the
T11461	21707-21716	NN	denotes	amplitude
T11462	21700-21706	JJ	denotes	median
T11463	21721-21723	IN	denotes	at
T11464	21724-21727	DT	denotes	the
T11465	21734-21737	NN	denotes	end
T11466	21728-21733	JJ	denotes	lower
T11467	21738-21740	IN	denotes	of
T11468	21741-21744	DT	denotes	the
T11469	21753-21758	NN	denotes	range
T11470	21745-21749	NN	denotes	E2f1
T11471	21750-21752	NN	denotes	KO
T11472	21758-21759	.	denotes	.
T11473	21759-22092	sentence	denotes	The photopic response in E2f1 KO mice was slightly reduced relative to WT (Figure S5B), possibly because E2f1 is required for maximal expansion of embryonic RPCs, and the E2f1 KO retina has, as noted earlier, slightly fewer cells than the WT retina, although cell type proportions are unaffected (D. C. and R. B., unpublished data).
T11474	21760-21763	DT	denotes	The
T11475	21773-21781	NN	denotes	response
T11476	21764-21772	JJ	denotes	photopic
T11477	21811-21818	VBN	denotes	reduced
T11478	21782-21784	IN	denotes	in
T11479	21785-21789	NN	denotes	E2f1
T11480	21790-21792	NN	denotes	KO
T11481	21793-21797	NNS	denotes	mice
T11482	21798-21801	VBD	denotes	was
T11483	21802-21810	RB	denotes	slightly
T11484	21819-21827	JJ	denotes	relative
T11485	21828-21830	IN	denotes	to
T11486	21831-21833	NN	denotes	WT
T11487	21834-21835	-LRB-	denotes	(
T11488	21842-21845	NN	denotes	S5B
T11489	21835-21841	NN	denotes	Figure
T11490	21845-21846	-RRB-	denotes	)
T11491	21846-21848	,	denotes	,
T11492	21848-21856	RB	denotes	possibly
T11493	21873-21881	VBN	denotes	required
T11494	21857-21864	IN	denotes	because
T11495	21865-21869	NN	denotes	E2f1
T11496	21870-21872	VBZ	denotes	is
T11497	21882-21885	IN	denotes	for
T11498	21886-21893	JJ	denotes	maximal
T11499	21894-21903	NN	denotes	expansion
T11500	21904-21906	IN	denotes	of
T11501	21907-21916	JJ	denotes	embryonic
T11502	21917-21921	NNS	denotes	RPCs
T11503	21921-21923	,	denotes	,
T11504	21923-21926	CC	denotes	and
T11505	21927-21930	DT	denotes	the
T11506	21939-21945	NN	denotes	retina
T11507	21931-21935	NN	denotes	E2f1
T11508	21936-21938	NN	denotes	KO
T11509	21946-21949	VBZ	denotes	has
T11510	21949-21951	,	denotes	,
T11511	21951-21953	IN	denotes	as
T11512	21954-21959	VBN	denotes	noted
T11513	21960-21967	RBR	denotes	earlier
T11514	21967-21969	,	denotes	,
T11515	21969-21977	RB	denotes	slightly
T11516	21978-21983	JJR	denotes	fewer
T11517	21984-21989	NNS	denotes	cells
T11518	21990-21994	IN	denotes	than
T11519	21995-21998	DT	denotes	the
T11520	22002-22008	NN	denotes	retina
T11521	21999-22001	NN	denotes	WT
T11522	22008-22010	,	denotes	,
T11523	22010-22018	IN	denotes	although
T11524	22041-22044	VBP	denotes	are
T11525	22019-22023	NN	denotes	cell
T11526	22024-22028	NN	denotes	type
T11527	22029-22040	NNS	denotes	proportions
T11528	22045-22055	JJ	denotes	unaffected
T11529	22056-22057	-LRB-	denotes	(
T11530	22057-22059	NNP	denotes	D.
T11531	22060-22062	NNP	denotes	C.
T11532	22063-22066	CC	denotes	and
T11533	22067-22069	NNP	denotes	R.
T11534	22070-22072	NNP	denotes	B.
T11535	22072-22074	,	denotes	,
T11536	22074-22085	JJ	denotes	unpublished
T11537	22086-22090	NNS	denotes	data
T11538	22090-22091	-RRB-	denotes	)
T11539	22091-22092	.	denotes	.
T11540	22092-22331	sentence	denotes	Thus, marginally subnormal photopic responses in the Rb/E2f1 DKO retina can be attributed to both a reduction of cone numbers in E2f1 KO mice alone, and a “genuine” slight reduction in cone function attributable to Rb loss relative to WT.
T11541	22093-22097	RB	denotes	Thus
T11542	22172-22182	VBN	denotes	attributed
T11543	22097-22099	,	denotes	,
T11544	22099-22109	RB	denotes	marginally
T11545	22110-22119	JJ	denotes	subnormal
T11546	22129-22138	NNS	denotes	responses
T11547	22120-22128	JJ	denotes	photopic
T11548	22139-22141	IN	denotes	in
T11549	22142-22145	DT	denotes	the
T11550	22158-22164	NN	denotes	retina
T11551	22146-22148	NN	denotes	Rb
T11552	22149-22153	NN	denotes	E2f1
T11553	22148-22149	HYPH	denotes	/
T11554	22154-22157	NN	denotes	DKO
T11555	22165-22168	MD	denotes	can
T11556	22169-22171	VB	denotes	be
T11557	22183-22185	IN	denotes	to
T11558	22186-22190	CC	denotes	both
T11559	22193-22202	NN	denotes	reduction
T11560	22191-22192	DT	denotes	a
T11561	22203-22205	IN	denotes	of
T11562	22206-22210	NN	denotes	cone
T11563	22211-22218	NNS	denotes	numbers
T11564	22219-22221	IN	denotes	in
T11565	22222-22226	NN	denotes	E2f1
T11566	22227-22229	NN	denotes	KO
T11567	22230-22234	NNS	denotes	mice
T11568	22235-22240	RB	denotes	alone
T11569	22240-22242	,	denotes	,
T11570	22242-22245	CC	denotes	and
T11571	22246-22247	DT	denotes	a
T11572	22265-22274	NN	denotes	reduction
T11573	22248-22249	``	denotes	“
T11574	22249-22256	JJ	denotes	genuine
T11575	22256-22257	''	denotes	”
T11576	22258-22264	JJ	denotes	slight
T11577	22275-22277	IN	denotes	in
T11578	22278-22282	NN	denotes	cone
T11579	22283-22291	NN	denotes	function
T11580	22292-22304	JJ	denotes	attributable
T11581	22305-22307	IN	denotes	to
T11582	22308-22310	NN	denotes	Rb
T11583	22311-22315	NN	denotes	loss
T11584	22316-22324	JJ	denotes	relative
T11585	22325-22327	IN	denotes	to
T11586	22328-22330	NN	denotes	WT
T11587	22330-22331	.	denotes	.
T11588	22331-22441	sentence	denotes	This slight effect may relate to a true differentiation defect in a subset of amacrine cells discussed below.
T11589	22332-22336	DT	denotes	This
T11590	22344-22350	NN	denotes	effect
T11591	22337-22343	JJ	denotes	slight
T11592	22355-22361	VB	denotes	relate
T11593	22351-22354	MD	denotes	may
T11594	22362-22364	IN	denotes	to
T11595	22365-22366	DT	denotes	a
T11596	22388-22394	NN	denotes	defect
T11597	22367-22371	JJ	denotes	true
T11598	22372-22387	NN	denotes	differentiation
T11599	22395-22397	IN	denotes	in
T11600	22398-22399	DT	denotes	a
T11601	22400-22406	NN	denotes	subset
T11602	22407-22409	IN	denotes	of
T11603	22410-22418	JJ	denotes	amacrine
T11604	22419-22424	NNS	denotes	cells
T11605	22425-22434	VBN	denotes	discussed
T11606	22435-22440	RB	denotes	below
T11607	22440-22441	.	denotes	.
T11608	22441-22548	sentence	denotes	This discussion should not obscure the major outcome that E2f1 deletion recovers most of the ERG response.
T11609	22442-22446	DT	denotes	This
T11610	22447-22457	NN	denotes	discussion
T11611	22469-22476	VB	denotes	obscure
T11612	22458-22464	MD	denotes	should
T11613	22465-22468	RB	denotes	not
T11614	22477-22480	DT	denotes	the
T11615	22487-22494	NN	denotes	outcome
T11616	22481-22486	JJ	denotes	major
T11617	22495-22499	IN	denotes	that
T11618	22514-22522	VBZ	denotes	recovers
T11619	22500-22504	NN	denotes	E2f1
T11620	22505-22513	NN	denotes	deletion
T11621	22523-22527	JJS	denotes	most
T11622	22528-22530	IN	denotes	of
T11623	22531-22534	DT	denotes	the
T11624	22539-22547	NN	denotes	response
T11625	22535-22538	NN	denotes	ERG
T11626	22547-22548	.	denotes	.
T11627	22548-22660	sentence	denotes	Thus, E2f1 deletion not only rescues morphology but also both rod and cone system function in the Rb KO retina.
T11628	22549-22553	RB	denotes	Thus
T11629	22560-22568	NN	denotes	deletion
T11630	22553-22555	,	denotes	,
T11631	22555-22559	NN	denotes	E2f1
T11632	22569-22572	RB	denotes	not
T11633	22573-22577	RB	denotes	only
T11634	22578-22585	VBZ	denotes	rescues
T11635	22586-22596	NN	denotes	morphology
T11636	22597-22600	CC	denotes	but
T11637	22601-22605	RB	denotes	also
T11638	22606-22610	CC	denotes	both
T11639	22611-22614	NN	denotes	rod
T11640	22631-22639	NN	denotes	function
T11641	22615-22618	CC	denotes	and
T11642	22619-22623	NN	denotes	cone
T11643	22624-22630	NN	denotes	system
T11644	22640-22642	IN	denotes	in
T11645	22643-22646	DT	denotes	the
T11646	22653-22659	NN	denotes	retina
T11647	22647-22649	NN	denotes	Rb
T11648	22650-22652	NN	denotes	KO
T11649	22659-22660	.	denotes	.
T13755	22662-22670	JJ	denotes	Abnormal
T13756	22675-22690	NN	denotes	Differentiation
T13757	22671-22674	NN	denotes	SAC
T13758	22691-22702	JJ	denotes	Independent
T13759	22703-22705	IN	denotes	of
T13760	22706-22710	NN	denotes	Cell
T13761	22711-22716	NN	denotes	Cycle
T13762	22717-22720	CC	denotes	and
T13763	22721-22729	NN	denotes	Survival
T13764	22730-22737	NNS	denotes	Defects
T13765	22737-22853	sentence	denotes	ERGs primarily assess photoreceptor and bipolar cell function, but may miss differentiation defects in other cells.
T13766	22738-22742	NNS	denotes	ERGs
T13767	22753-22759	VBP	denotes	assess
T13768	22743-22752	RB	denotes	primarily
T13769	22760-22773	NN	denotes	photoreceptor
T13770	22791-22799	NN	denotes	function
T13771	22774-22777	CC	denotes	and
T13772	22778-22785	JJ	denotes	bipolar
T13773	22786-22790	NN	denotes	cell
T13774	22799-22801	,	denotes	,
T13775	22801-22804	CC	denotes	but
T13776	22805-22808	MD	denotes	may
T13777	22809-22813	VB	denotes	miss
T13778	22814-22829	NN	denotes	differentiation
T13779	22830-22837	NNS	denotes	defects
T13780	22838-22840	IN	denotes	in
T13781	22841-22846	JJ	denotes	other
T13782	22847-22852	NNS	denotes	cells
T13783	22852-22853	.	denotes	.
T13784	22853-22946	sentence	denotes	To test for subtle differences we stained the Rb/E2f1 DKO retina with 43 markers (Table S1).
T13785	22854-22856	TO	denotes	To
T13786	22857-22861	VB	denotes	test
T13787	22888-22895	VBD	denotes	stained
T13788	22862-22865	IN	denotes	for
T13789	22866-22872	JJ	denotes	subtle
T13790	22873-22884	NNS	denotes	differences
T13791	22885-22887	PRP	denotes	we
T13792	22896-22899	DT	denotes	the
T13793	22912-22918	NN	denotes	retina
T13794	22900-22902	NN	denotes	Rb
T13795	22903-22907	NN	denotes	E2f1
T13796	22902-22903	HYPH	denotes	/
T13797	22908-22911	NN	denotes	DKO
T13798	22919-22923	IN	denotes	with
T13799	22924-22926	CD	denotes	43
T13800	22927-22934	NNS	denotes	markers
T13801	22935-22936	-LRB-	denotes	(
T13802	22942-22944	NN	denotes	S1
T13803	22936-22941	NN	denotes	Table
T13804	22944-22945	-RRB-	denotes	)
T13805	22945-22946	.	denotes	.
T13806	22946-23046	sentence	denotes	Thirty-two proteins displayed identical patterns in WT, E2f1 KO, and Rb/E2f1 DKO retina (Table S1).
T13807	22947-22953	CD	denotes	Thirty
T13808	22954-22957	CD	denotes	two
T13809	22953-22954	HYPH	denotes	-
T13810	22958-22966	NN	denotes	proteins
T13811	22967-22976	VBD	denotes	displayed
T13812	22977-22986	JJ	denotes	identical
T13813	22987-22995	NNS	denotes	patterns
T13814	22996-22998	IN	denotes	in
T13815	22999-23001	NN	denotes	WT
T13816	23028-23034	NN	denotes	retina
T13817	23001-23003	,	denotes	,
T13818	23003-23007	NN	denotes	E2f1
T13819	23008-23010	NN	denotes	KO
T13820	23010-23012	,	denotes	,
T13821	23012-23015	CC	denotes	and
T13822	23016-23018	NN	denotes	Rb
T13823	23019-23023	NN	denotes	E2f1
T13824	23018-23019	HYPH	denotes	/
T13825	23024-23027	NN	denotes	DKO
T13826	23035-23036	-LRB-	denotes	(
T13827	23042-23044	NN	denotes	S1
T13828	23036-23041	NN	denotes	Table
T13829	23044-23045	-RRB-	denotes	)
T13830	23045-23046	.	denotes	.
T13831	23046-23148	sentence	denotes	The other 11 markers revealed a cell-cycle– and apoptosis-independent differentiation defect in SACs.
T13832	23047-23050	DT	denotes	The
T13833	23060-23067	NNS	denotes	markers
T13834	23051-23056	JJ	denotes	other
T13835	23057-23059	CD	denotes	11
T13836	23068-23076	VBD	denotes	revealed
T13837	23077-23078	DT	denotes	a
T13838	23133-23139	NN	denotes	defect
T13839	23079-23083	NN	denotes	cell
T13840	23084-23089	NN	denotes	cycle
T13841	23083-23084	HYPH	denotes	-
T13842	23105-23116	JJ	denotes	independent
T13843	23089-23090	HYPH	denotes	–
T13844	23091-23094	CC	denotes	and
T13845	23095-23104	NN	denotes	apoptosis
T13846	23104-23105	HYPH	denotes	-
T13847	23117-23132	NN	denotes	differentiation
T13848	23140-23142	IN	denotes	in
T13849	23143-23147	NNS	denotes	SACs
T13850	23147-23148	.	denotes	.
T13851	23148-23324	sentence	denotes	We first studied Calb2 (calretinin), which marks a subset of amacrine and ganglion cell bodies as well as three tracks corresponding to their processes in the IPL (Figure 3A).
T13852	23149-23151	PRP	denotes	We
T13853	23158-23165	VBD	denotes	studied
T13854	23152-23157	RB	denotes	first
T13855	23166-23171	NN	denotes	Calb2
T13856	23172-23173	-LRB-	denotes	(
T13857	23173-23183	NN	denotes	calretinin
T13858	23183-23184	-RRB-	denotes	)
T13859	23184-23186	,	denotes	,
T13860	23186-23191	WDT	denotes	which
T13861	23192-23197	VBZ	denotes	marks
T13862	23198-23199	DT	denotes	a
T13863	23200-23206	NN	denotes	subset
T13864	23207-23209	IN	denotes	of
T13865	23210-23218	JJ	denotes	amacrine
T13866	23237-23243	NNS	denotes	bodies
T13867	23219-23222	CC	denotes	and
T13868	23223-23231	NN	denotes	ganglion
T13869	23232-23236	NN	denotes	cell
T13870	23244-23246	RB	denotes	as
T13871	23252-23254	IN	denotes	as
T13872	23247-23251	RB	denotes	well
T13873	23255-23260	CD	denotes	three
T13874	23261-23267	NNS	denotes	tracks
T13875	23268-23281	VBG	denotes	corresponding
T13876	23282-23284	IN	denotes	to
T13877	23285-23290	PRP$	denotes	their
T13878	23291-23300	NNS	denotes	processes
T13879	23301-23303	IN	denotes	in
T13880	23304-23307	DT	denotes	the
T13881	23308-23311	NN	denotes	IPL
T13882	23312-23313	-LRB-	denotes	(
T13883	23320-23322	NN	denotes	3A
T13884	23313-23319	NN	denotes	Figure
T13885	23322-23323	-RRB-	denotes	)
T13886	23323-23324	.	denotes	.
T13887	23324-23392	sentence	denotes	Normal Calb2 staining was seen in the E2f1 KO IPL (data not shown).
T13888	23325-23331	JJ	denotes	Normal
T13889	23338-23346	NN	denotes	staining
T13890	23332-23337	NN	denotes	Calb2
T13891	23351-23355	VBN	denotes	seen
T13892	23347-23350	VBD	denotes	was
T13893	23356-23358	IN	denotes	in
T13894	23359-23362	DT	denotes	the
T13895	23371-23374	NN	denotes	IPL
T13896	23363-23367	NN	denotes	E2f1
T13897	23368-23370	NN	denotes	KO
T13898	23375-23376	-LRB-	denotes	(
T13899	23385-23390	VBN	denotes	shown
T13900	23376-23380	NNS	denotes	data
T13901	23381-23384	RB	denotes	not
T13902	23390-23391	-RRB-	denotes	)
T13903	23391-23392	.	denotes	.
T13904	23392-23524	sentence	denotes	However, only one Calb2+ track was evident in the Rb KO IPL, and this defect was not rescued in the Rb/E2f1 DKO retina (Figure 3A).
T13905	23393-23400	RB	denotes	However
T13906	23424-23427	VBD	denotes	was
T13907	23400-23402	,	denotes	,
T13908	23402-23406	RB	denotes	only
T13909	23418-23423	NN	denotes	track
T13910	23407-23410	CD	denotes	one
T13911	23411-23416	NN	denotes	Calb2
T13912	23416-23417	SYM	denotes	+
T13913	23428-23435	JJ	denotes	evident
T13914	23436-23438	IN	denotes	in
T13915	23439-23442	DT	denotes	the
T13916	23449-23452	NN	denotes	IPL
T13917	23443-23445	NN	denotes	Rb
T13918	23446-23448	NN	denotes	KO
T13919	23452-23454	,	denotes	,
T13920	23454-23457	CC	denotes	and
T13921	23458-23462	DT	denotes	this
T13922	23463-23469	NN	denotes	defect
T13923	23478-23485	VBN	denotes	rescued
T13924	23470-23473	VBD	denotes	was
T13925	23474-23477	RB	denotes	not
T13926	23486-23488	IN	denotes	in
T13927	23489-23492	DT	denotes	the
T13928	23505-23511	NN	denotes	retina
T13929	23493-23495	NN	denotes	Rb
T13930	23496-23500	NN	denotes	E2f1
T13931	23495-23496	HYPH	denotes	/
T13932	23501-23504	NN	denotes	DKO
T13933	23512-23513	-LRB-	denotes	(
T13934	23520-23522	NN	denotes	3A
T14033	24661-24664	CD	denotes	5.2
T14034	24664-24665	NN	denotes	%
T14035	24666-24668	IN	denotes	of
T14036	24669-24677	JJ	denotes	amacrine
T14037	24678-24685	NNS	denotes	neurons
T14038	24686-24687	-LRB-	denotes	[
T14039	24687-24689	CD	denotes	38
T14040	24689-24690	-RRB-	denotes	]
T14041	24690-24692	,	denotes	,
T14042	24692-24695	CC	denotes	and
T14043	24696-24699	VBP	denotes	are
T14044	24700-24708	JJ	denotes	critical
T14045	24709-24712	IN	denotes	for
T14046	24713-24717	CC	denotes	both
T14047	24728-24739	NN	denotes	selectivity
T14048	24718-24727	NN	denotes	direction
T14049	24740-24741	-LRB-	denotes	[
T14050	24744-24746	CD	denotes	35
T14051	24741-24743	CD	denotes	34
T14052	24743-24744	,	denotes	,
T14053	24746-24747	-RRB-	denotes	]
T14054	24748-24751	CC	denotes	and
T14055	24752-24763	JJ	denotes	spontaneous
T14056	24773-24781	NN	denotes	activity
T14057	24764-24772	JJ	denotes	rhythmic
T14058	24782-24786	WDT	denotes	that
T14059	24787-24793	VBZ	denotes	occurs
T14060	24794-24800	IN	denotes	during
T14061	24801-24807	JJ	denotes	normal
T14062	24816-24827	NN	denotes	development
T14063	24808-24815	JJ	denotes	retinal
T14064	24828-24829	-LRB-	denotes	[
T14065	24829-24831	CD	denotes	36
T14066	24831-24832	-RRB-	denotes	]
T14067	24832-24833	.	denotes	.
T14068	24833-25068	sentence	denotes	SACs in the INL synapse in the OFF layer of the IPL that responds to decreasing light, while displaced SACs in the GCL have processes that synapse in the nearby ON layer of the IPL that responds to increasing light (reviewed in [39]).
T14069	24834-24838	NNS	denotes	SACs
T14070	24850-24857	VBP	denotes	synapse
T14071	24839-24841	IN	denotes	in
T14072	24842-24845	DT	denotes	the
T14073	24846-24849	NN	denotes	INL
T14074	24858-24860	IN	denotes	in
T14075	24861-24864	DT	denotes	the
T14076	24869-24874	NN	denotes	layer
T14077	24865-24868	NN	denotes	OFF
T14078	24875-24877	IN	denotes	of
T14079	24878-24881	DT	denotes	the
T14080	24882-24885	NN	denotes	IPL
T14081	24886-24890	WDT	denotes	that
T14082	24891-24899	VBZ	denotes	responds
T14083	24900-24902	IN	denotes	to
T14084	24903-24913	VBG	denotes	decreasing
T14085	24914-24919	NN	denotes	light
T14086	24919-24921	,	denotes	,
T14087	24921-24926	IN	denotes	while
T14088	24953-24957	VBP	denotes	have
T14089	24927-24936	VBN	denotes	displaced
T14090	24937-24941	NNS	denotes	SACs
T14091	24942-24944	IN	denotes	in
T14092	24945-24948	DT	denotes	the
T14093	24949-24952	NN	denotes	GCL
T14094	24958-24967	NNS	denotes	processes
T14095	24968-24972	WDT	denotes	that
T14096	24973-24980	VBP	denotes	synapse
T14097	24981-24983	IN	denotes	in
T14098	24984-24987	DT	denotes	the
T14099	24998-25003	NN	denotes	layer
T14100	24988-24994	JJ	denotes	nearby
T14101	24995-24997	NN	denotes	ON
T14102	25004-25006	IN	denotes	of
T14103	25007-25010	DT	denotes	the
T14104	25011-25014	NN	denotes	IPL
T14105	25015-25019	WDT	denotes	that
T14106	25020-25028	VBZ	denotes	responds
T14107	25029-25031	IN	denotes	to
T14108	25032-25042	VBG	denotes	increasing
T14109	25043-25048	NN	denotes	light
T14110	25049-25050	-LRB-	denotes	(
T14111	25050-25058	VBN	denotes	reviewed
T14112	25059-25061	IN	denotes	in
T14113	25062-25063	-LRB-	denotes	[
T14114	25063-25065	CD	denotes	39
T14115	25065-25066	-RRB-	denotes	]
T14116	25066-25067	-RRB-	denotes	)
T14117	25067-25068	.	denotes	.
T14118	25068-25287	sentence	denotes	Mature SAC processes stain specifically for Slc18a3 (vesicular acetyl choline transporter, VAChT) [37], and, significantly, this marker was absent in the peripheral Rb KO or Rb/E2f1 DKO P18 retina (Figures 3A and S7B).
T14119	25069-25075	JJ	denotes	Mature
T14120	25080-25089	NNS	denotes	processes
T14121	25076-25079	NN	denotes	SAC
T14122	25090-25095	VBP	denotes	stain
T14123	25096-25108	RB	denotes	specifically
T14124	25109-25112	IN	denotes	for
T14125	25113-25120	NN	denotes	Slc18a3
T14126	25121-25122	-LRB-	denotes	(
T14127	25122-25131	JJ	denotes	vesicular
T14128	25147-25158	NN	denotes	transporter
T14129	25132-25138	NN	denotes	acetyl
T14130	25139-25146	NN	denotes	choline
T14131	25158-25160	,	denotes	,
T14132	25160-25165	NN	denotes	VAChT
T14133	25165-25166	-RRB-	denotes	)
T14134	25167-25168	-LRB-	denotes	[
T14135	25168-25170	CD	denotes	37
T14136	25170-25171	-RRB-	denotes	]
T14137	25171-25173	,	denotes	,
T14138	25173-25176	CC	denotes	and
T14139	25176-25178	,	denotes	,
T14140	25178-25191	RB	denotes	significantly
T14141	25205-25208	VBD	denotes	was
T14142	25191-25193	,	denotes	,
T14143	25193-25197	DT	denotes	this
T14144	25198-25204	NN	denotes	marker
T14145	25209-25215	JJ	denotes	absent
T14146	25216-25218	IN	denotes	in
T14147	25219-25222	DT	denotes	the
T14148	25259-25265	NN	denotes	retina
T14149	25223-25233	JJ	denotes	peripheral
T14150	25234-25236	NN	denotes	Rb
T14151	25237-25239	NN	denotes	KO
T14152	25240-25242	CC	denotes	or
T14153	25243-25245	NN	denotes	Rb
T14154	25246-25250	NN	denotes	E2f1
T14155	25245-25246	HYPH	denotes	/
T14156	25251-25254	NN	denotes	DKO
T14157	25255-25258	NN	denotes	P18
T14158	25266-25267	-LRB-	denotes	(
T14159	25275-25277	NN	denotes	3A
T14160	25267-25274	NNS	denotes	Figures
T14161	25278-25281	CC	denotes	and
T14162	25282-25285	NN	denotes	S7B
T14163	25285-25286	-RRB-	denotes	)
T14164	25286-25287	.	denotes	.
T14165	25287-25408	sentence	denotes	Chat, expressed from the same locus, is also SAC specific, but marks both cell bodies and processes of mature SACs [37].
T14166	25288-25292	NN	denotes	Chat
T14167	25325-25327	VBZ	denotes	is
T14168	25292-25294	,	denotes	,
T14169	25294-25303	VBN	denotes	expressed
T14170	25304-25308	IN	denotes	from
T14171	25309-25312	DT	denotes	the
T14172	25318-25323	NN	denotes	locus
T14173	25313-25317	JJ	denotes	same
T14174	25323-25325	,	denotes	,
T14175	25328-25332	RB	denotes	also
T14176	25333-25336	NN	denotes	SAC
T14177	25337-25345	JJ	denotes	specific
T14178	25345-25347	,	denotes	,
T14179	25347-25350	CC	denotes	but
T14180	25351-25356	VBZ	denotes	marks
T14181	25357-25361	CC	denotes	both
T14182	25367-25373	NNS	denotes	bodies
T14183	25362-25366	NN	denotes	cell
T14184	25374-25377	CC	denotes	and
T14185	25378-25387	NNS	denotes	processes
T14186	25388-25390	IN	denotes	of
T14187	25391-25397	JJ	denotes	mature
T14188	25398-25402	NNS	denotes	SACs
T14189	25403-25404	-LRB-	denotes	[
T14190	25404-25406	CD	denotes	37
T14191	25406-25407	-RRB-	denotes	]
T14192	25407-25408	.	denotes	.
T14193	25408-25532	sentence	denotes	Chat was seen in fewer cells in the mature Rb KO retina, and was present in the soma but absent from processes (Figure 3B).
T14194	25409-25413	NN	denotes	Chat
T14195	25418-25422	VBN	denotes	seen
T14196	25414-25417	VBD	denotes	was
T14197	25423-25425	IN	denotes	in
T14198	25426-25431	JJR	denotes	fewer
T14199	25432-25437	NNS	denotes	cells
T14200	25438-25440	IN	denotes	in
T14201	25441-25444	DT	denotes	the
T14202	25458-25464	NN	denotes	retina
T14203	25445-25451	JJ	denotes	mature
T14204	25452-25454	NN	denotes	Rb
T14205	25455-25457	NN	denotes	KO
T14206	25464-25466	,	denotes	,
T14207	25466-25469	CC	denotes	and
T14208	25470-25473	VBD	denotes	was
T14209	25474-25481	JJ	denotes	present
T14210	25482-25484	IN	denotes	in
T14211	25485-25488	DT	denotes	the
T14212	25489-25493	NN	denotes	soma
T14213	25494-25497	CC	denotes	but
T14214	25498-25504	JJ	denotes	absent
T14215	25505-25509	IN	denotes	from
T14216	25510-25519	NNS	denotes	processes
T14217	25520-25521	-LRB-	denotes	(
T14218	25528-25530	NN	denotes	3B
T14219	25521-25527	NN	denotes	Figure
T14220	25530-25531	-RRB-	denotes	)
T14221	25531-25532	.	denotes	.
T14222	25532-26065	sentence	denotes	We obtained similar results for Sv2c, a synaptic vesicle protein found in SACs [40]; Kcnc1b and Kcnc2, potassium channels expressed on SAC soma and dendrites as well as a very small number of ganglion cells [41]; gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter present in about half of amacrine cells including SACs, as well as horizontal and some bipolar neurons [37]; and Calb1 (calbindin), which is expressed in many amacrine cells and labels SAC process faintly (Figure S7A and S7B; Table S1; and data not shown).
T14223	25533-25535	PRP	denotes	We
T14224	25536-25544	VBD	denotes	obtained
T14225	25545-25552	JJ	denotes	similar
T14226	25553-25560	NNS	denotes	results
T14227	25561-25564	IN	denotes	for
T14228	25565-25569	NN	denotes	Sv2c
T14229	25569-25571	,	denotes	,
T14230	25571-25572	DT	denotes	a
T14231	25590-25597	NN	denotes	protein
T14232	25573-25581	JJ	denotes	synaptic
T14233	25582-25589	NN	denotes	vesicle
T14234	25598-25603	VBN	denotes	found
T14235	25604-25606	IN	denotes	in
T14236	25607-25611	NNS	denotes	SACs
T14237	25612-25613	-LRB-	denotes	[
T14238	25613-25615	CD	denotes	40
T14239	25615-25616	-RRB-	denotes	]
T14240	25616-25617	:	denotes	;
T14241	25618-25624	NN	denotes	Kcnc1b
T14242	25625-25628	CC	denotes	and
T14243	25629-25634	NN	denotes	Kcnc2
T14244	25634-25636	,	denotes	,
T14245	25636-25645	NN	denotes	potassium
T14246	25646-25654	NNS	denotes	channels
T14247	25655-25664	VBN	denotes	expressed
T14248	25665-25667	IN	denotes	on
T14249	25668-25671	NN	denotes	SAC
T14250	25672-25676	NN	denotes	soma
T14251	25677-25680	CC	denotes	and
T14252	25681-25690	VBZ	denotes	dendrites
T14253	25691-25693	RB	denotes	as
T14254	25699-25701	IN	denotes	as
T14255	25694-25698	RB	denotes	well
T14256	25702-25703	DT	denotes	a
T14257	25715-25721	NN	denotes	number
T14258	25704-25708	RB	denotes	very
T14259	25709-25714	JJ	denotes	small
T14260	25722-25724	IN	denotes	of
T14261	25725-25733	NN	denotes	ganglion
T14262	25734-25739	NNS	denotes	cells
T14263	25740-25741	-LRB-	denotes	[
T14264	25741-25743	CD	denotes	41
T14265	25743-25744	-RRB-	denotes	]
T14266	25744-25745	:	denotes	;
T14267	25746-25751	NN	denotes	gamma
T14268	25765-25769	NN	denotes	acid
T14269	25751-25752	HYPH	denotes	-
T14270	25752-25764	JJ	denotes	aminobutyric
T14271	25770-25771	-LRB-	denotes	(
T14272	25771-25775	NN	denotes	GABA
T14273	25775-25776	-RRB-	denotes	)
T14274	25776-25778	,	denotes	,
T14275	25778-25780	DT	denotes	an
T14276	25792-25808	NN	denotes	neurotransmitter
T14277	25781-25791	JJ	denotes	inhibitory
T14278	25809-25816	JJ	denotes	present
T14279	25817-25819	IN	denotes	in
T14280	25820-25825	IN	denotes	about
T14281	25826-25830	NN	denotes	half
T14282	25831-25833	IN	denotes	of
T14283	25834-25842	JJ	denotes	amacrine
T14284	25843-25848	NNS	denotes	cells
T14285	25849-25858	VBG	denotes	including
T14286	25859-25863	NNS	denotes	SACs
T14287	25863-25865	,	denotes	,
T14288	25865-25867	RB	denotes	as
T14289	25873-25875	IN	denotes	as
T14290	25868-25872	RB	denotes	well
T14291	25876-25886	JJ	denotes	horizontal
T14292	25887-25890	CC	denotes	and
T14293	25891-25895	DT	denotes	some
T14294	25896-25903	JJ	denotes	bipolar
T14295	25904-25911	NNS	denotes	neurons
T14296	25912-25913	-LRB-	denotes	[
T14297	25913-25915	CD	denotes	37
T14298	25915-25916	-RRB-	denotes	]
T14299	25916-25917	:	denotes	;
T14300	25918-25921	CC	denotes	and
T14301	25922-25927	NN	denotes	Calb1
T14302	25928-25929	-LRB-	denotes	(
T14303	25929-25938	NN	denotes	calbindin
T14304	25938-25939	-RRB-	denotes	)
T14305	25939-25941	,	denotes	,
T14306	25941-25946	WDT	denotes	which
T14307	25950-25959	VBN	denotes	expressed
T14308	25947-25949	VBZ	denotes	is
T14309	25960-25962	IN	denotes	in
T14310	25963-25967	JJ	denotes	many
T14311	25977-25982	NNS	denotes	cells
T14312	25968-25976	JJ	denotes	amacrine
T14313	25983-25986	CC	denotes	and
T14314	25987-25993	VBZ	denotes	labels
T14315	25994-25997	NN	denotes	SAC
T14316	25998-26005	NN	denotes	process
T14317	26006-26013	RB	denotes	faintly
T14318	26014-26015	-LRB-	denotes	(
T14319	26022-26025	NN	denotes	S7A
T14320	26015-26021	NN	denotes	Figure
T14321	26026-26029	CC	denotes	and
T14322	26030-26033	NN	denotes	S7B
T14323	26033-26034	:	denotes	;
T14324	26035-26040	NN	denotes	Table
T14325	26041-26043	NN	denotes	S1
T14326	26043-26044	:	denotes	;
T14327	26045-26048	CC	denotes	and
T14328	26049-26053	NNS	denotes	data
T14329	26058-26063	VBN	denotes	shown
T14330	26054-26057	RB	denotes	not
T14331	26063-26064	-RRB-	denotes	)
T14332	26064-26065	.	denotes	.
T14333	26065-26274	sentence	denotes	Finally, we also examined the effect of Rb deletion on SAC differentiation using a Chx10-Cre transgene that is expressed in a mosaic pattern across the retina, generating patches of Cre-expressing cells [42].
T14334	26066-26073	RB	denotes	Finally
T14335	26083-26091	VBD	denotes	examined
T14336	26073-26075	,	denotes	,
T14337	26075-26077	PRP	denotes	we
T14338	26078-26082	RB	denotes	also
T14339	26092-26095	DT	denotes	the
T14340	26096-26102	NN	denotes	effect
T14341	26103-26105	IN	denotes	of
T14342	26106-26108	NN	denotes	Rb
T14343	26109-26117	NN	denotes	deletion
T14344	26118-26120	IN	denotes	on
T14345	26121-26124	NN	denotes	SAC
T14346	26125-26140	NN	denotes	differentiation
T14347	26141-26146	VBG	denotes	using
T14348	26147-26148	DT	denotes	a
T14349	26159-26168	NN	denotes	transgene
T14350	26149-26154	NN	denotes	Chx10
T14351	26155-26158	NN	denotes	Cre
T14352	26154-26155	HYPH	denotes	-
T14353	26169-26173	WDT	denotes	that
T14354	26177-26186	VBN	denotes	expressed
T14355	26174-26176	VBZ	denotes	is
T14356	26187-26189	IN	denotes	in
T14357	26190-26191	DT	denotes	a
T14358	26199-26206	NN	denotes	pattern
T14359	26192-26198	JJ	denotes	mosaic
T14360	26207-26213	IN	denotes	across
T14361	26214-26217	DT	denotes	the
T14362	26218-26224	NN	denotes	retina
T14363	26224-26226	,	denotes	,
T14364	26226-26236	VBG	denotes	generating
T14365	26237-26244	NNS	denotes	patches
T14366	26245-26247	IN	denotes	of
T14367	26248-26251	NN	denotes	Cre
T14368	26252-26262	VBG	denotes	expressing
T14369	26251-26252	HYPH	denotes	-
T14370	26263-26268	NNS	denotes	cells
T14371	26269-26270	-LRB-	denotes	[
T14372	26270-26272	CD	denotes	42
T14373	26272-26273	-RRB-	denotes	]
T14374	26273-26274	.	denotes	.
T14375	26274-26442	sentence	denotes	Consistent with the mosaic deletion pattern, we observed markedly reduced Chat/Slc18a3 staining in the IPL of Chx10-Cre;RbloxP/loxP retina compared to WT (Figure S7C).
T14376	26275-26285	JJ	denotes	Consistent
T14377	26323-26331	VBD	denotes	observed
T14378	26286-26290	IN	denotes	with
T14379	26291-26294	DT	denotes	the
T14380	26311-26318	NN	denotes	pattern
T14381	26295-26301	JJ	denotes	mosaic
T14382	26302-26310	NN	denotes	deletion
T14383	26318-26320	,	denotes	,
T14384	26320-26322	PRP	denotes	we
T14385	26332-26340	RB	denotes	markedly
T14386	26341-26348	VBN	denotes	reduced
T14387	26362-26370	NN	denotes	staining
T14388	26349-26353	NN	denotes	Chat
T14389	26354-26361	NN	denotes	Slc18a3
T14390	26353-26354	HYPH	denotes	/
T14391	26371-26373	IN	denotes	in
T14392	26374-26377	DT	denotes	the
T14393	26378-26381	NN	denotes	IPL
T14394	26382-26384	IN	denotes	of
T14395	26385-26390	NN	denotes	Chx10
T14396	26391-26394	NN	denotes	Cre
T14397	26390-26391	HYPH	denotes	-
T14398	26407-26413	NN	denotes	retina
T14399	26394-26395	:	denotes	;
T14400	26395-26401	NN	denotes	RbloxP
T14401	26402-26406	NN	denotes	loxP
T14402	26401-26402	HYPH	denotes	/
T14403	26414-26422	VBN	denotes	compared
T14404	26423-26425	IN	denotes	to
T14405	26426-26428	NN	denotes	WT
T14406	26429-26430	-LRB-	denotes	(
T14407	26437-26440	NN	denotes	S7C
T14408	26430-26436	NN	denotes	Figure
T14409	26440-26441	-RRB-	denotes	)
T14410	26441-26442	.	denotes	.
T14411	26442-26512	sentence	denotes	Together, these results suggest a role for Rb in SAC differentiation.
T14412	26443-26451	RB	denotes	Together
T14413	26467-26474	VBP	denotes	suggest
T14414	26451-26453	,	denotes	,
T14415	26453-26458	DT	denotes	these
T14416	26459-26466	NNS	denotes	results
T14417	26475-26476	DT	denotes	a
T14418	26477-26481	NN	denotes	role
T14419	26482-26485	IN	denotes	for
T14420	26486-26488	NN	denotes	Rb
T14421	26489-26491	IN	denotes	in
T14422	26492-26495	NN	denotes	SAC
T14423	26496-26511	NN	denotes	differentiation
T14424	26511-26512	.	denotes	.
T14425	26512-26654	sentence	denotes	The above findings could indicate a defect in SAC specification, SAC survival, or the levels and/or transport of the markers described above.
T14426	26513-26516	DT	denotes	The
T14427	26523-26531	NNS	denotes	findings
T14428	26517-26522	JJ	denotes	above
T14429	26538-26546	VB	denotes	indicate
T14430	26532-26537	MD	denotes	could
T14431	26547-26548	DT	denotes	a
T14432	26549-26555	NN	denotes	defect
T14433	26556-26558	IN	denotes	in
T14434	26559-26562	NN	denotes	SAC
T14435	26563-26576	NN	denotes	specification
T14436	26576-26578	,	denotes	,
T14437	26578-26581	NN	denotes	SAC
T14438	26582-26590	NN	denotes	survival
T14439	26590-26592	,	denotes	,
T14440	26592-26594	CC	denotes	or
T14441	26595-26598	DT	denotes	the
T14442	26599-26605	NNS	denotes	levels
T14443	26606-26609	CC	denotes	and
T14444	26609-26610	HYPH	denotes	/
T14445	26610-26612	CC	denotes	or
T14446	26613-26622	NN	denotes	transport
T14447	26623-26625	IN	denotes	of
T14448	26626-26629	DT	denotes	the
T14449	26630-26637	NNS	denotes	markers
T14450	26638-26647	VBN	denotes	described
T14451	26648-26653	RB	denotes	above
T14452	26653-26654	.	denotes	.
T14453	26654-26814	sentence	denotes	Camk2a marks both SACs and ganglion cells [37], but because ganglion cells are eliminated in the Rb KO retina, Camk2a is a specific SAC marker in this context.
T14454	26655-26661	NN	denotes	Camk2a
T14455	26662-26667	VBZ	denotes	marks
T14456	26668-26672	CC	denotes	both
T14457	26673-26677	NNS	denotes	SACs
T14458	26678-26681	CC	denotes	and
T14459	26682-26690	NN	denotes	ganglion
T14460	26691-26696	NNS	denotes	cells
T14461	26697-26698	-LRB-	denotes	[
T14462	26698-26700	CD	denotes	37
T14463	26700-26701	-RRB-	denotes	]
T14464	26701-26703	,	denotes	,
T14465	26703-26706	CC	denotes	but
T14466	26707-26714	IN	denotes	because
T14467	26734-26744	VBN	denotes	eliminated
T14468	26715-26723	NN	denotes	ganglion
T14469	26724-26729	NNS	denotes	cells
T14470	26730-26733	VBP	denotes	are
T14471	26773-26775	VBZ	denotes	is
T14472	26745-26747	IN	denotes	in
T14473	26748-26751	DT	denotes	the
T14474	26758-26764	NN	denotes	retina
T14475	26752-26754	NN	denotes	Rb
T14476	26755-26757	NN	denotes	KO
T14477	26764-26766	,	denotes	,
T14478	26766-26772	NN	denotes	Camk2a
T14479	26776-26777	DT	denotes	a
T14480	26791-26797	NN	denotes	marker
T14481	26778-26786	JJ	denotes	specific
T14482	26787-26790	NN	denotes	SAC
T14483	26798-26800	IN	denotes	in
T14484	26801-26805	DT	denotes	this
T14485	26806-26813	NN	denotes	context
T14486	26813-26814	.	denotes	.
T14487	26814-27111	sentence	denotes	Importantly, Camk2a+ tracks and dendrites were present in both the WT and Rb KO retina (Figure 3B), and the number of Camk2a+ soma was similar in WT and Rb KO retina at P30 and beyond, although fewer cells stained in Rb KO retina at P18, suggesting a delay in its appearance (Figures 3C and S6B).
T14488	26815-26826	RB	denotes	Importantly
T14489	26857-26861	VBD	denotes	were
T14490	26826-26828	,	denotes	,
T14491	26828-26834	NN	denotes	Camk2a
T14492	26834-26835	SYM	denotes	+
T14493	26836-26842	NNS	denotes	tracks
T14494	26843-26846	CC	denotes	and
T14495	26847-26856	NNS	denotes	dendrites
T14496	26862-26869	JJ	denotes	present
T14497	26870-26872	IN	denotes	in
T14498	26873-26877	CC	denotes	both
T14499	26895-26901	NN	denotes	retina
T14500	26878-26881	DT	denotes	the
T14501	26882-26884	NN	denotes	WT
T14502	26885-26888	CC	denotes	and
T14503	26889-26891	NN	denotes	Rb
T14504	26892-26894	NN	denotes	KO
T14505	26902-26903	-LRB-	denotes	(
T14506	26910-26912	NN	denotes	3B
T14507	26903-26909	NN	denotes	Figure
T14508	26912-26913	-RRB-	denotes	)
T14509	26913-26915	,	denotes	,
T14510	26915-26918	CC	denotes	and
T14511	26919-26922	DT	denotes	the
T14512	26923-26929	NN	denotes	number
T14513	26946-26949	VBD	denotes	was
T14514	26930-26932	IN	denotes	of
T14515	26933-26939	NN	denotes	Camk2a
T14516	26941-26945	NN	denotes	soma
T14517	26939-26940	SYM	denotes	+
T14518	26950-26957	JJ	denotes	similar
T14519	26958-26960	IN	denotes	in
T14520	26961-26963	NN	denotes	WT
T14521	26974-26980	NN	denotes	retina
T14522	26964-26967	CC	denotes	and
T14523	26968-26970	NN	denotes	Rb
T14524	26971-26973	NN	denotes	KO
T14525	26981-26983	IN	denotes	at
T14526	26984-26987	NN	denotes	P30
T14527	26988-26991	CC	denotes	and
T14528	26992-26998	RB	denotes	beyond
T14529	26998-27000	,	denotes	,
T14530	27000-27008	IN	denotes	although
T14531	27021-27028	VBN	denotes	stained
T14532	27009-27014	JJR	denotes	fewer
T14533	27015-27020	NNS	denotes	cells
T14534	27029-27031	IN	denotes	in
T14535	27032-27034	NN	denotes	Rb
T14536	27035-27037	NN	denotes	KO
T14537	27038-27044	NN	denotes	retina
T14538	27045-27047	IN	denotes	at
T14539	27048-27051	NN	denotes	P18
T14540	27051-27053	,	denotes	,
T14541	27053-27063	VBG	denotes	suggesting
T14542	27064-27065	DT	denotes	a
T14543	27066-27071	NN	denotes	delay
T14544	27072-27074	IN	denotes	in
T14545	27075-27078	PRP$	denotes	its
T14546	27079-27089	NN	denotes	appearance
T14547	27090-27091	-LRB-	denotes	(
T14548	27099-27101	NN	denotes	3C
T14549	27091-27098	NNS	denotes	Figures
T14550	27102-27105	CC	denotes	and
T14551	27106-27109	NN	denotes	S6B
T14552	27109-27110	-RRB-	denotes	)
T14553	27110-27111	.	denotes	.
T14554	27111-27365	sentence	denotes	Thus, Rb is not required for SAC survival or for process outgrowth, but rather it seems to regulate the expression and/or stability of Calb2, Calb1, Chat, Slc18a3, Sv2c, Kcnc1b, Kcnc2, and GABA in SACs, but leaves Camk2a expression virtually unaffected.
T14555	27112-27116	RB	denotes	Thus
T14556	27128-27136	VBN	denotes	required
T14557	27116-27118	,	denotes	,
T14558	27118-27120	NN	denotes	Rb
T14559	27121-27123	VBZ	denotes	is
T14560	27124-27127	RB	denotes	not
T14561	27137-27140	IN	denotes	for
T14562	27141-27144	NN	denotes	SAC
T14563	27145-27153	NN	denotes	survival
T14564	27154-27156	CC	denotes	or
T14565	27157-27160	IN	denotes	for
T14566	27161-27168	NN	denotes	process
T14567	27169-27178	NN	denotes	outgrowth
T14568	27178-27180	,	denotes	,
T14569	27180-27183	CC	denotes	but
T14570	27184-27190	RB	denotes	rather
T14571	27191-27193	PRP	denotes	it
T14572	27194-27199	VBZ	denotes	seems
T14573	27200-27202	TO	denotes	to
T14574	27203-27211	VB	denotes	regulate
T14575	27212-27215	DT	denotes	the
T14576	27216-27226	NN	denotes	expression
T14577	27227-27230	CC	denotes	and
T14578	27230-27231	HYPH	denotes	/
T14579	27231-27233	CC	denotes	or
T14580	27234-27243	NN	denotes	stability
T14581	27244-27246	IN	denotes	of
T14582	27247-27252	NN	denotes	Calb2
T14583	27252-27254	,	denotes	,
T14584	27254-27259	NN	denotes	Calb1
T14585	27259-27261	,	denotes	,
T14586	27261-27265	NN	denotes	Chat
T14587	27265-27267	,	denotes	,
T14588	27267-27274	NN	denotes	Slc18a3
T14589	27274-27276	,	denotes	,
T14590	27276-27280	NN	denotes	Sv2c
T14591	27280-27282	,	denotes	,
T14592	27282-27288	NN	denotes	Kcnc1b
T14593	27288-27290	,	denotes	,
T14594	27290-27295	NN	denotes	Kcnc2
T14595	27295-27297	,	denotes	,
T14596	27297-27300	CC	denotes	and
T14597	27301-27305	NN	denotes	GABA
T14598	27306-27308	IN	denotes	in
T14599	27309-27313	NNS	denotes	SACs
T14600	27313-27315	,	denotes	,
T14601	27315-27318	CC	denotes	but
T14602	27319-27325	VBZ	denotes	leaves
T14603	27326-27332	NN	denotes	Camk2a
T14604	27333-27343	NN	denotes	expression
T14605	27344-27353	RB	denotes	virtually
T14606	27354-27364	JJ	denotes	unaffected
T14607	27364-27365	.	denotes	.
T14608	27365-27475	sentence	denotes	The presence of Chat in some cell bodies but never in processes (Figure 3B) also suggests a transport defect.
T14609	27366-27369	DT	denotes	The
T14610	27370-27378	NN	denotes	presence
T14611	27447-27455	VBZ	denotes	suggests
T14612	27379-27381	IN	denotes	of
T14613	27382-27386	NN	denotes	Chat
T14614	27387-27389	IN	denotes	in
T14615	27390-27394	DT	denotes	some
T14616	27400-27406	NNS	denotes	bodies
T14617	27395-27399	NN	denotes	cell
T14618	27407-27410	CC	denotes	but
T14619	27411-27416	RB	denotes	never
T14620	27417-27419	IN	denotes	in
T14621	27420-27429	NNS	denotes	processes
T14622	27430-27431	-LRB-	denotes	(
T14623	27438-27440	NN	denotes	3B
T14624	27431-27437	NN	denotes	Figure
T14625	27440-27441	-RRB-	denotes	)
T14626	27442-27446	RB	denotes	also
T14627	27456-27457	DT	denotes	a
T14628	27468-27474	NN	denotes	defect
T14629	27458-27467	NN	denotes	transport
T14630	27474-27475	.	denotes	.
T14631	27475-27551	sentence	denotes	The developmental pattern of Slc18a3 expression also supported this notion.
T14632	27476-27479	DT	denotes	The
T14633	27494-27501	NN	denotes	pattern
T14634	27480-27493	JJ	denotes	developmental
T14635	27529-27538	VBD	denotes	supported
T14636	27502-27504	IN	denotes	of
T14637	27505-27512	NN	denotes	Slc18a3
T14638	27513-27523	NN	denotes	expression
T14639	27524-27528	RB	denotes	also
T14640	27539-27543	DT	denotes	this
T14641	27544-27550	NN	denotes	notion
T14642	27550-27551	.	denotes	.
T14643	27551-27716	sentence	denotes	In mature WT SACs Slc18a3 is only in processes, but in early postnatal SACs, it is found in the cell body, and moves into emerging processes at approximately P4–P6.
T14644	27552-27554	IN	denotes	In
T14645	27578-27580	VBZ	denotes	is
T14646	27555-27561	JJ	denotes	mature
T14647	27565-27569	NNS	denotes	SACs
T14648	27562-27564	NN	denotes	WT
T14649	27570-27577	NN	denotes	Slc18a3
T14650	27581-27585	RB	denotes	only
T14651	27586-27588	IN	denotes	in
T14652	27589-27598	NNS	denotes	processes
T14653	27598-27600	,	denotes	,
T14654	27600-27603	CC	denotes	but
T14655	27604-27606	IN	denotes	in
T14656	27635-27640	VBN	denotes	found
T14657	27607-27612	JJ	denotes	early
T14658	27623-27627	NNS	denotes	SACs
T14659	27613-27622	JJ	denotes	postnatal
T14660	27627-27629	,	denotes	,
T14661	27629-27631	PRP	denotes	it
T14662	27632-27634	VBZ	denotes	is
T14663	27641-27643	IN	denotes	in
T14664	27644-27647	DT	denotes	the
T14665	27653-27657	NN	denotes	body
T14666	27648-27652	NN	denotes	cell
T14667	27657-27659	,	denotes	,
T14668	27659-27662	CC	denotes	and
T14669	27663-27668	VBZ	denotes	moves
T14670	27669-27673	IN	denotes	into
T14671	27674-27682	VBG	denotes	emerging
T14672	27683-27692	NNS	denotes	processes
T14673	27693-27695	IN	denotes	at
T14674	27696-27709	RB	denotes	approximately
T14675	27710-27712	NN	denotes	P4
T14676	27712-27713	SYM	denotes	–
T14677	27713-27715	NN	denotes	P6
T14678	27715-27716	.	denotes	.
T14679	27716-27889	sentence	denotes	As noted above, Slc18a3 was absent at P18 in the Rb KO retina (Figure 3A); at P4 or P5 it was in cell bodies, yet was rarely present in Rb KO processes (Figures 4A and S6).
T14680	27717-27719	IN	denotes	As
T14681	27720-27725	VBN	denotes	noted
T14682	27741-27744	VBD	denotes	was
T14683	27726-27731	RB	denotes	above
T14684	27731-27733	,	denotes	,
T14685	27733-27740	NN	denotes	Slc18a3
T14686	27807-27810	VBD	denotes	was
T14687	27745-27751	JJ	denotes	absent
T14688	27752-27754	IN	denotes	at
T14689	27755-27758	NN	denotes	P18
T14690	27759-27761	IN	denotes	in
T14691	27762-27765	DT	denotes	the
T14692	27772-27778	NN	denotes	retina
T14693	27766-27768	NN	denotes	Rb
T14694	27769-27771	NN	denotes	KO
T14695	27779-27780	-LRB-	denotes	(
T14696	27787-27789	NN	denotes	3A
T14697	27780-27786	NN	denotes	Figure
T14698	27789-27790	-RRB-	denotes	)
T14699	27790-27791	:	denotes	;
T14700	27792-27794	IN	denotes	at
T14701	27795-27797	NN	denotes	P4
T14702	27798-27800	CC	denotes	or
T14703	27801-27803	NN	denotes	P5
T14704	27804-27806	PRP	denotes	it
T14705	27811-27813	IN	denotes	in
T14706	27814-27818	NN	denotes	cell
T14707	27819-27825	NNS	denotes	bodies
T14708	27825-27827	,	denotes	,
T14709	27827-27830	CC	denotes	yet
T14710	27831-27834	VBD	denotes	was
T14711	27835-27841	RB	denotes	rarely
T14712	27842-27849	JJ	denotes	present
T14713	27850-27852	IN	denotes	in
T14714	27853-27855	NN	denotes	Rb
T14715	27856-27858	NN	denotes	KO
T14716	27859-27868	NNS	denotes	processes
T14717	27869-27870	-LRB-	denotes	(
T14718	27878-27880	NN	denotes	4A
T14719	27870-27877	NNS	denotes	Figures
T14720	27881-27884	CC	denotes	and
T14721	27885-27887	NN	denotes	S6
T14722	27887-27888	-RRB-	denotes	)
T14723	27888-27889	.	denotes	.
T14724	27889-27969	sentence	denotes	Slc18a3 became virtually undetectable in Rb KO SACs by P8 (Figures 3C and S6C).
T14725	27890-27897	NN	denotes	Slc18a3
T14726	27898-27904	VBD	denotes	became
T14727	27905-27914	RB	denotes	virtually
T14728	27915-27927	JJ	denotes	undetectable
T14729	27928-27930	IN	denotes	in
T14730	27931-27933	NN	denotes	Rb
T14731	27934-27936	NN	denotes	KO
T14732	27937-27941	NNS	denotes	SACs
T14733	27942-27944	IN	denotes	by
T14734	27945-27947	NN	denotes	P8
T14735	27948-27949	-LRB-	denotes	(
T14736	27957-27959	NN	denotes	3C
T14737	27949-27956	NNS	denotes	Figures
T14738	27960-27963	CC	denotes	and
T14739	27964-27967	NN	denotes	S6C
T14740	27967-27968	-RRB-	denotes	)
T14741	27968-27969	.	denotes	.
T14742	27969-28063	sentence	denotes	These data suggest that Rb affects both the synthesis/stability and transport of SAC markers.
T14743	27970-27975	DT	denotes	These
T14744	27976-27980	NNS	denotes	data
T14745	27981-27988	VBP	denotes	suggest
T14746	27989-27993	IN	denotes	that
T14747	27997-28004	VBZ	denotes	affects
T14748	27994-27996	NN	denotes	Rb
T14749	28005-28009	CC	denotes	both
T14750	28024-28033	NN	denotes	stability
T14751	28010-28013	DT	denotes	the
T14752	28014-28023	NN	denotes	synthesis
T14753	28023-28024	HYPH	denotes	/
T14754	28034-28037	CC	denotes	and
T14755	28038-28047	NN	denotes	transport
T14756	28048-28050	IN	denotes	of
T14757	28051-28054	NN	denotes	SAC
T14758	28055-28062	NNS	denotes	markers
T14759	28062-28063	.	denotes	.
T16394	29528-29530	NN	denotes	Rb
T16395	29531-29540	VBZ	denotes	Regulates
T16396	29541-29544	NN	denotes	SAC
T16397	29545-29560	NN	denotes	Differentiation
T16398	29561-29568	IN	denotes	through
T16399	29569-29573	NN	denotes	E2f3
T16400	29573-29802	sentence	denotes	Rb binds more than 100 proteins [43] and in some non-neuronal cells, such as skeletal muscle, adipocytes, and bone, Rb is thought to bind and potentiate tissue-specific transcription factors that promote differentiation [31–33].
T16401	29574-29576	NN	denotes	Rb
T16402	29577-29582	VBZ	denotes	binds
T16403	29583-29587	JJR	denotes	more
T16404	29593-29596	CD	denotes	100
T16405	29588-29592	IN	denotes	than
T16406	29597-29605	NN	denotes	proteins
T16407	29606-29607	-LRB-	denotes	[
T16408	29607-29609	CD	denotes	43
T16409	29609-29610	-RRB-	denotes	]
T16410	29611-29614	CC	denotes	and
T16411	29615-29617	IN	denotes	in
T16412	29696-29703	VBN	denotes	thought
T16413	29618-29622	DT	denotes	some
T16414	29636-29641	NNS	denotes	cells
T16415	29623-29635	JJ	denotes	non-neuronal
T16416	29641-29643	,	denotes	,
T16417	29643-29647	JJ	denotes	such
T16418	29648-29650	IN	denotes	as
T16419	29651-29659	JJ	denotes	skeletal
T16420	29660-29666	NN	denotes	muscle
T16421	29666-29668	,	denotes	,
T16422	29668-29678	NNS	denotes	adipocytes
T16423	29678-29680	,	denotes	,
T16424	29680-29683	CC	denotes	and
T16425	29684-29688	NN	denotes	bone
T16426	29688-29690	,	denotes	,
T16427	29690-29692	NN	denotes	Rb
T16428	29693-29695	VBZ	denotes	is
T16429	29704-29706	TO	denotes	to
T16430	29707-29711	VB	denotes	bind
T16431	29712-29715	CC	denotes	and
T16432	29716-29726	VB	denotes	potentiate
T16433	29727-29733	NN	denotes	tissue
T16434	29734-29742	JJ	denotes	specific
T16435	29733-29734	HYPH	denotes	-
T16436	29757-29764	NNS	denotes	factors
T16437	29743-29756	NN	denotes	transcription
T16438	29765-29769	WDT	denotes	that
T16439	29770-29777	VBP	denotes	promote
T16440	29778-29793	NN	denotes	differentiation
T16441	29794-29795	-LRB-	denotes	[
T16442	29795-29797	CD	denotes	31
T16443	29797-29798	SYM	denotes	–
T16444	29798-29800	CD	denotes	33
T16445	29800-29801	-RRB-	denotes	]
T16446	29801-29802	.	denotes	.
T16447	29802-29907	sentence	denotes	Thus, we expected that Rb might interact with retina-specific factors to facilitate SAC differentiation.
T16448	29803-29807	RB	denotes	Thus
T16449	29812-29820	VBD	denotes	expected
T16450	29807-29809	,	denotes	,
T16451	29809-29811	PRP	denotes	we
T16452	29821-29825	IN	denotes	that
T16453	29835-29843	VB	denotes	interact
T16454	29826-29828	NN	denotes	Rb
T16455	29829-29834	MD	denotes	might
T16456	29844-29848	IN	denotes	with
T16457	29849-29855	NN	denotes	retina
T16458	29856-29864	JJ	denotes	specific
T16459	29855-29856	HYPH	denotes	-
T16460	29865-29872	NNS	denotes	factors
T16461	29873-29875	TO	denotes	to
T16462	29876-29886	VB	denotes	facilitate
T16463	29887-29890	NN	denotes	SAC
T16464	29891-29906	NN	denotes	differentiation
T16465	29906-29907	.	denotes	.
T16466	29907-30203	sentence	denotes	A direct role for E2f in mediating Rb-dependent differentiation defects (independent of cell cycle or death defects) has to our knowledge not been described, but because E2f can regulate some differentiation genes [44–48], we first tested whether E2f2 or E2f3 might perturb Rb KO SAC maturation.
T16467	29908-29909	DT	denotes	A
T16468	29917-29921	NN	denotes	role
T16469	29910-29916	JJ	denotes	direct
T16470	30055-30064	VBN	denotes	described
T16471	29922-29925	IN	denotes	for
T16472	29926-29929	NN	denotes	E2f
T16473	29930-29932	IN	denotes	in
T16474	29933-29942	VBG	denotes	mediating
T16475	29943-29945	NN	denotes	Rb
T16476	29946-29955	JJ	denotes	dependent
T16477	29945-29946	HYPH	denotes	-
T16478	29972-29979	NNS	denotes	defects
T16479	29956-29971	NN	denotes	differentiation
T16480	29980-29981	-LRB-	denotes	(
T16481	29981-29992	JJ	denotes	independent
T16482	29993-29995	IN	denotes	of
T16483	29996-30000	NN	denotes	cell
T16484	30001-30006	NN	denotes	cycle
T16485	30016-30023	NNS	denotes	defects
T16486	30007-30009	CC	denotes	or
T16487	30010-30015	NN	denotes	death
T16488	30023-30024	-RRB-	denotes	)
T16489	30025-30028	VBZ	denotes	has
T16490	30029-30031	IN	denotes	to
T16491	30032-30035	PRP$	denotes	our
T16492	30036-30045	NN	denotes	knowledge
T16493	30046-30049	RB	denotes	not
T16494	30050-30054	VBN	denotes	been
T16495	30064-30066	,	denotes	,
T16496	30066-30069	CC	denotes	but
T16497	30070-30077	IN	denotes	because
T16498	30086-30094	VB	denotes	regulate
T16499	30078-30081	NN	denotes	E2f
T16500	30082-30085	MD	denotes	can
T16501	30140-30146	VBD	denotes	tested
T16502	30095-30099	DT	denotes	some
T16503	30116-30121	NNS	denotes	genes
T16504	30100-30115	NN	denotes	differentiation
T16505	30122-30123	-LRB-	denotes	[
T16506	30123-30125	CD	denotes	44
T16507	30125-30126	SYM	denotes	–
T16508	30126-30128	CD	denotes	48
T16509	30128-30129	-RRB-	denotes	]
T16510	30129-30131	,	denotes	,
T16511	30131-30133	PRP	denotes	we
T16512	30134-30139	RB	denotes	first
T16513	30147-30154	IN	denotes	whether
T16514	30174-30181	VB	denotes	perturb
T16515	30155-30159	NN	denotes	E2f2
T16516	30160-30162	CC	denotes	or
T16517	30163-30167	NN	denotes	E2f3
T16518	30168-30173	MD	denotes	might
T16519	30182-30184	NN	denotes	Rb
T16520	30185-30187	NN	denotes	KO
T16521	30188-30191	NN	denotes	SAC
T16522	30192-30202	NN	denotes	maturation
T16523	30202-30203	.	denotes	.
T16524	30203-30381	sentence	denotes	At multiple time points, E2f1 deletion suppressed ectopic mitosis (PH3+ cells), but did not reverse the SAC defect, and E2f2 deletion had no effect on either defect (Figure 4A).
T16525	30204-30206	IN	denotes	At
T16526	30243-30253	VBD	denotes	suppressed
T16527	30207-30215	JJ	denotes	multiple
T16528	30221-30227	NNS	denotes	points
T16529	30216-30220	NN	denotes	time
T16530	30227-30229	,	denotes	,
T16531	30229-30233	NN	denotes	E2f1
T16532	30234-30242	NN	denotes	deletion
T16533	30254-30261	JJ	denotes	ectopic
T16534	30262-30269	NN	denotes	mitosis
T16535	30270-30271	-LRB-	denotes	(
T16536	30276-30281	NNS	denotes	cells
T16537	30271-30274	NN	denotes	PH3
T16538	30274-30275	SYM	denotes	+
T16539	30281-30282	-RRB-	denotes	)
T16540	30282-30284	,	denotes	,
T16541	30284-30287	CC	denotes	but
T16542	30288-30291	VBD	denotes	did
T16543	30296-30303	VB	denotes	reverse
T16544	30292-30295	RB	denotes	not
T16545	30304-30307	DT	denotes	the
T16546	30312-30318	NN	denotes	defect
T16547	30308-30311	NN	denotes	SAC
T16548	30318-30320	,	denotes	,
T16549	30320-30323	CC	denotes	and
T16550	30324-30328	NN	denotes	E2f2
T16551	30329-30337	NN	denotes	deletion
T16552	30338-30341	VBD	denotes	had
T16553	30342-30344	DT	denotes	no
T16554	30345-30351	NN	denotes	effect
T16555	30352-30354	IN	denotes	on
T16556	30355-30361	CC	denotes	either
T16557	30362-30368	NN	denotes	defect
T16558	30369-30370	-LRB-	denotes	(
T16559	30377-30379	NN	denotes	4A
T16560	30370-30376	NN	denotes	Figure
T16561	30379-30380	-RRB-	denotes	)
T16562	30380-30381	.	denotes	.
T16563	30381-30571	sentence	denotes	Remarkably, although E2f3 deletion did not reverse ectopic mitosis, it rescued Calb2, Slc18a3, Chat, GABA, Kcnc1b, Kcnc2, and Sv2c staining at multiple times (Figure 4A and data not shown).
T16564	30382-30392	RB	denotes	Remarkably
T16565	30453-30460	VBD	denotes	rescued
T16566	30392-30394	,	denotes	,
T16567	30394-30402	IN	denotes	although
T16568	30425-30432	VB	denotes	reverse
T16569	30403-30407	NN	denotes	E2f3
T16570	30408-30416	NN	denotes	deletion
T16571	30417-30420	VBD	denotes	did
T16572	30421-30424	RB	denotes	not
T16573	30433-30440	JJ	denotes	ectopic
T16574	30441-30448	NN	denotes	mitosis
T16575	30448-30450	,	denotes	,
T16576	30450-30452	PRP	denotes	it
T16577	30461-30466	NN	denotes	Calb2
T16578	30513-30521	NN	denotes	staining
T16579	30466-30468	,	denotes	,
T16580	30468-30475	NN	denotes	Slc18a3
T16581	30475-30477	,	denotes	,
T16582	30477-30481	NN	denotes	Chat
T16583	30481-30483	,	denotes	,
T16584	30483-30487	NN	denotes	GABA
T16585	30487-30489	,	denotes	,
T16586	30489-30495	NN	denotes	Kcnc1b
T16587	30495-30497	,	denotes	,
T16588	30497-30502	NN	denotes	Kcnc2
T16589	30502-30504	,	denotes	,
T16590	30504-30507	CC	denotes	and
T16591	30508-30512	NN	denotes	Sv2c
T16592	30522-30524	IN	denotes	at
T16593	30525-30533	JJ	denotes	multiple
T16594	30534-30539	NNS	denotes	times
T16595	30540-30541	-LRB-	denotes	(
T16596	30548-30550	NN	denotes	4A
T16597	30541-30547	NN	denotes	Figure
T16598	30551-30554	CC	denotes	and
T16599	30555-30559	NNS	denotes	data
T16600	30564-30569	VBN	denotes	shown
T16601	30560-30563	RB	denotes	not
T16602	30569-30570	-RRB-	denotes	)
T16603	30570-30571	.	denotes	.
T16604	30571-30731	sentence	denotes	Rb/E2f3 DKO SAC tracks were slightly more disordered than in WT retina, most likely because of the absence of synaptic partner cells, which are killed by E2f1.
T16605	30572-30574	NN	denotes	Rb
T16606	30575-30579	NN	denotes	E2f3
T16607	30574-30575	HYPH	denotes	/
T16608	30580-30583	NN	denotes	DKO
T16609	30584-30587	NN	denotes	SAC
T16610	30588-30594	NNS	denotes	tracks
T16611	30595-30599	VBD	denotes	were
T16612	30600-30608	RB	denotes	slightly
T16613	30609-30613	RBR	denotes	more
T16614	30614-30624	VBN	denotes	disordered
T16615	30625-30629	IN	denotes	than
T16616	30630-30632	IN	denotes	in
T16617	30633-30635	NN	denotes	WT
T16618	30636-30642	NN	denotes	retina
T16619	30642-30644	,	denotes	,
T16620	30644-30648	RBS	denotes	most
T16621	30649-30655	RB	denotes	likely
T16622	30656-30663	IN	denotes	because
T16623	30664-30666	IN	denotes	of
T16624	30667-30670	DT	denotes	the
T16625	30671-30678	NN	denotes	absence
T16626	30679-30681	IN	denotes	of
T16627	30682-30690	JJ	denotes	synaptic
T16628	30699-30704	NNS	denotes	cells
T16629	30691-30698	NN	denotes	partner
T16630	30704-30706	,	denotes	,
T16631	30706-30711	WDT	denotes	which
T16632	30716-30722	VBN	denotes	killed
T16633	30712-30715	VBP	denotes	are
T16634	30723-30725	IN	denotes	by
T16635	30726-30730	NN	denotes	E2f1
T16636	30730-30731	.	denotes	.
T16637	30731-30913	sentence	denotes	Indeed, this minor defect was rescued in the Rb/E2f1/E2f3 triple knockout retina, where bipolar and ganglion cell death was rescued and SAC differentiation was restored (Figure 4A).
T16638	30732-30738	RB	denotes	Indeed
T16639	30762-30769	VBN	denotes	rescued
T16640	30738-30740	,	denotes	,
T16641	30740-30744	DT	denotes	this
T16642	30751-30757	NN	denotes	defect
T16643	30745-30750	JJ	denotes	minor
T16644	30758-30761	VBD	denotes	was
T16645	30770-30772	IN	denotes	in
T16646	30773-30776	DT	denotes	the
T16647	30806-30812	NN	denotes	retina
T16648	30777-30779	NN	denotes	Rb
T16649	30785-30789	NN	denotes	E2f3
T16650	30779-30780	HYPH	denotes	/
T16651	30780-30784	NN	denotes	E2f1
T16652	30784-30785	HYPH	denotes	/
T16653	30797-30805	NN	denotes	knockout
T16654	30790-30796	JJ	denotes	triple
T16655	30812-30814	,	denotes	,
T16656	30814-30819	WRB	denotes	where
T16657	30856-30863	VBN	denotes	rescued
T16658	30820-30827	JJ	denotes	bipolar
T16659	30841-30845	NN	denotes	cell
T16660	30828-30831	CC	denotes	and
T16661	30832-30840	NN	denotes	ganglion
T16662	30846-30851	NN	denotes	death
T16663	30852-30855	VBD	denotes	was
T16664	30864-30867	CC	denotes	and
T16665	30868-30871	NN	denotes	SAC
T16666	30872-30887	NN	denotes	differentiation
T16667	30892-30900	VBN	denotes	restored
T16668	30888-30891	VBD	denotes	was
T16669	30901-30902	-LRB-	denotes	(
T16670	30909-30911	NN	denotes	4A
T16671	30902-30908	NN	denotes	Figure
T16672	30911-30912	-RRB-	denotes	)
T16673	30912-30913	.	denotes	.
T16674	30913-31087	sentence	denotes	E2f3 deletion alone did not affect SAC differentiation (Figure 4A); thus, it is unleashed E2f3 activity that is detrimental, and the critical role for Rb is to inhibit E2f3.
T16675	30914-30918	NN	denotes	E2f3
T16676	30919-30927	NN	denotes	deletion
T16677	30942-30948	VB	denotes	affect
T16678	30928-30933	RB	denotes	alone
T16679	30934-30937	VBD	denotes	did
T16680	30938-30941	RB	denotes	not
T16681	30949-30952	NN	denotes	SAC
T16682	30953-30968	NN	denotes	differentiation
T16683	30969-30970	-LRB-	denotes	(
T16684	30977-30979	NN	denotes	4A
T16685	30970-30976	NN	denotes	Figure
T16686	30979-30980	-RRB-	denotes	)
T16687	30980-30981	:	denotes	;
T16688	30982-30986	RB	denotes	thus
T16689	30991-30993	VBZ	denotes	is
T16690	30986-30988	,	denotes	,
T16691	30988-30990	PRP	denotes	it
T16692	30994-31003	VBN	denotes	unleashed
T16693	31009-31017	NN	denotes	activity
T16694	31004-31008	NN	denotes	E2f3
T16695	31018-31022	WDT	denotes	that
T16696	31023-31025	VBZ	denotes	is
T16697	31026-31037	JJ	denotes	detrimental
T16698	31037-31039	,	denotes	,
T16699	31039-31042	CC	denotes	and
T16700	31043-31046	DT	denotes	the
T16701	31056-31060	NN	denotes	role
T16702	31047-31055	JJ	denotes	critical
T16703	31068-31070	VBZ	denotes	is
T16704	31061-31064	IN	denotes	for
T16705	31065-31067	NN	denotes	Rb
T16706	31071-31073	TO	denotes	to
T16707	31074-31081	VB	denotes	inhibit
T16708	31082-31086	NN	denotes	E2f3
T16709	31086-31087	.	denotes	.
T16710	31087-31379	sentence	denotes	We quantified the fraction of Camk2a+ SACs in different genotypes and found that 60% of WT P30 Camk2a+ cells expressed Chat and Slc18a3, which dropped to only 5.6% in the Rb KO retina, and remained low at 3.7% in the Rb/E2f1 DKO retina, but rose to 91% in the Rb/E2f3 DKO retina (Figure 4B).
T16711	31088-31090	PRP	denotes	We
T16712	31091-31101	VBD	denotes	quantified
T16713	31102-31105	DT	denotes	the
T16714	31106-31114	NN	denotes	fraction
T16715	31115-31117	IN	denotes	of
T16716	31118-31124	NN	denotes	Camk2a
T16717	31126-31130	NNS	denotes	SACs
T16718	31124-31125	SYM	denotes	+
T16719	31131-31133	IN	denotes	in
T16720	31134-31143	JJ	denotes	different
T16721	31144-31153	NNS	denotes	genotypes
T16722	31154-31157	CC	denotes	and
T16723	31158-31163	VBD	denotes	found
T16724	31164-31168	IN	denotes	that
T16725	31197-31206	VBD	denotes	expressed
T16726	31169-31171	CD	denotes	60
T16727	31171-31172	NN	denotes	%
T16728	31173-31175	IN	denotes	of
T16729	31176-31178	NN	denotes	WT
T16730	31191-31196	NNS	denotes	cells
T16731	31179-31182	NN	denotes	P30
T16732	31183-31189	NN	denotes	Camk2a
T16733	31189-31190	SYM	denotes	+
T16734	31207-31211	NN	denotes	Chat
T16735	31212-31215	CC	denotes	and
T16736	31216-31223	NN	denotes	Slc18a3
T16737	31223-31225	,	denotes	,
T16738	31225-31230	WDT	denotes	which
T16739	31231-31238	VBD	denotes	dropped
T16740	31239-31241	IN	denotes	to
T16741	31242-31246	RB	denotes	only
T16742	31247-31250	CD	denotes	5.6
T16743	31250-31251	NN	denotes	%
T16744	31252-31254	IN	denotes	in
T16745	31255-31258	DT	denotes	the
T16746	31265-31271	NN	denotes	retina
T16747	31259-31261	NN	denotes	Rb
T16748	31262-31264	NN	denotes	KO
T16749	31271-31273	,	denotes	,
T16750	31273-31276	CC	denotes	and
T16751	31277-31285	VBD	denotes	remained
T16752	31286-31289	JJ	denotes	low
T16753	31290-31292	IN	denotes	at
T16754	31293-31296	CD	denotes	3.7
T16755	31296-31297	NN	denotes	%
T16756	31298-31300	IN	denotes	in
T16757	31301-31304	DT	denotes	the
T16758	31317-31323	NN	denotes	retina
T16759	31305-31307	NN	denotes	Rb
T16760	31308-31312	NN	denotes	E2f1
T16761	31307-31308	HYPH	denotes	/
T16762	31313-31316	NN	denotes	DKO
T16763	31323-31325	,	denotes	,
T16764	31325-31328	CC	denotes	but
T16765	31329-31333	VBD	denotes	rose
T16766	31334-31336	IN	denotes	to
T16767	31337-31339	CD	denotes	91
T16768	31339-31340	NN	denotes	%
T16769	31341-31343	IN	denotes	in
T16770	31344-31347	DT	denotes	the
T16771	31360-31366	NN	denotes	retina
T16772	31348-31350	NN	denotes	Rb
T16773	31351-31355	NN	denotes	E2f3
T16774	31350-31351	HYPH	denotes	/
T16775	31356-31359	NN	denotes	DKO
T16776	31367-31368	-LRB-	denotes	(
T16777	31375-31377	NN	denotes	4B
T16778	31368-31374	NN	denotes	Figure
T16779	31377-31378	-RRB-	denotes	)
T16780	31378-31379	.	denotes	.
T16781	31379-31512	sentence	denotes	The latter fraction is higher than WT because ganglion cells, which normally make up ~40% of Camk2a+ cells, are killed by apoptosis.
T16782	31380-31383	DT	denotes	The
T16783	31391-31399	NN	denotes	fraction
T16784	31384-31390	JJ	denotes	latter
T16785	31400-31402	VBZ	denotes	is
T16786	31403-31409	JJR	denotes	higher
T16787	31410-31414	IN	denotes	than
T16788	31415-31417	NN	denotes	WT
T16789	31418-31425	IN	denotes	because
T16790	31492-31498	VBN	denotes	killed
T16791	31426-31434	NN	denotes	ganglion
T16792	31435-31440	NNS	denotes	cells
T16793	31440-31442	,	denotes	,
T16794	31442-31447	WDT	denotes	which
T16795	31457-31461	VBP	denotes	make
T16796	31448-31456	RB	denotes	normally
T16797	31462-31464	RP	denotes	up
T16798	31465-31466	SYM	denotes	~
T16799	31466-31468	CD	denotes	40
T16800	31468-31469	NN	denotes	%
T16801	31470-31472	IN	denotes	of
T16802	31473-31479	NN	denotes	Camk2a
T16803	31481-31486	NNS	denotes	cells
T16804	31479-31480	SYM	denotes	+
T16805	31486-31488	,	denotes	,
T16806	31488-31491	VBP	denotes	are
T16807	31499-31501	IN	denotes	by
T16808	31502-31511	NN	denotes	apoptosis
T16809	31511-31512	.	denotes	.
T16810	31512-31623	sentence	denotes	To quantify the effect of different E2fs on ectopic division specifically in SACs, we exploited Isl1 (Islet1).
T16811	31513-31515	TO	denotes	To
T16812	31516-31524	VB	denotes	quantify
T16813	31599-31608	VBD	denotes	exploited
T16814	31525-31528	DT	denotes	the
T16815	31529-31535	NN	denotes	effect
T16816	31536-31538	IN	denotes	of
T16817	31539-31548	JJ	denotes	different
T16818	31549-31553	NNS	denotes	E2fs
T16819	31554-31556	IN	denotes	on
T16820	31557-31564	JJ	denotes	ectopic
T16821	31565-31573	NN	denotes	division
T16822	31574-31586	RB	denotes	specifically
T16823	31587-31589	IN	denotes	in
T16824	31590-31594	NNS	denotes	SACs
T16825	31594-31596	,	denotes	,
T16826	31596-31598	PRP	denotes	we
T16827	31609-31613	NN	denotes	Isl1
T16828	31614-31615	-LRB-	denotes	(
T16829	31615-31621	NN	denotes	Islet1
T16830	31621-31622	-RRB-	denotes	)
T16831	31622-31623	.	denotes	.
T16832	31623-31736	sentence	denotes	This marker is expressed in both SACs and ganglion cells, thus Isl1+ cells in the INL are exclusively SACs [49].
T16833	31624-31628	DT	denotes	This
T16834	31629-31635	NN	denotes	marker
T16835	31639-31648	VBN	denotes	expressed
T16836	31636-31638	VBZ	denotes	is
T16837	31710-31713	VBP	denotes	are
T16838	31649-31651	IN	denotes	in
T16839	31652-31656	CC	denotes	both
T16840	31657-31661	NNS	denotes	SACs
T16841	31662-31665	CC	denotes	and
T16842	31666-31674	NN	denotes	ganglion
T16843	31675-31680	NNS	denotes	cells
T16844	31680-31682	,	denotes	,
T16845	31682-31686	RB	denotes	thus
T16846	31687-31691	NN	denotes	Isl1
T16847	31693-31698	NNS	denotes	cells
T16848	31691-31692	SYM	denotes	+
T16849	31699-31701	IN	denotes	in
T16850	31702-31705	DT	denotes	the
T16851	31706-31709	NN	denotes	INL
T16852	31714-31725	RB	denotes	exclusively
T16853	31726-31730	NNS	denotes	SACs
T16854	31731-31732	-LRB-	denotes	[
T16855	31732-31734	CD	denotes	49
T16856	31734-31735	-RRB-	denotes	]
T16857	31735-31736	.	denotes	.
T16858	31736-31890	sentence	denotes	We found that 98.2% ± 1.8% of Isl1+ cells in the forming inner INL at P5 were also Slc18a3+, confirming that Isl1 is an excellent SAC marker (Figure 4C).
T16859	31737-31739	PRP	denotes	We
T16860	31740-31745	VBD	denotes	found
T16861	31746-31750	IN	denotes	that
T16862	31810-31814	VBD	denotes	were
T16863	31751-31755	CD	denotes	98.2
T16864	31755-31756	NN	denotes	%
T16865	31757-31758	SYM	denotes	±
T16866	31759-31762	CD	denotes	1.8
T16867	31762-31763	NN	denotes	%
T16868	31764-31766	IN	denotes	of
T16869	31767-31771	NN	denotes	Isl1
T16870	31773-31778	NNS	denotes	cells
T16871	31771-31772	SYM	denotes	+
T16872	31779-31781	IN	denotes	in
T16873	31782-31785	DT	denotes	the
T16874	31800-31803	NN	denotes	INL
T16875	31786-31793	VBG	denotes	forming
T16876	31794-31799	JJ	denotes	inner
T16877	31804-31806	IN	denotes	at
T16878	31807-31809	NN	denotes	P5
T16879	31815-31819	RB	denotes	also
T16880	31820-31827	NN	denotes	Slc18a3
T16881	31827-31828	SYM	denotes	+
T16882	31828-31830	,	denotes	,
T16883	31830-31840	VBG	denotes	confirming
T16884	31841-31845	IN	denotes	that
T16885	31851-31853	VBZ	denotes	is
T16886	31846-31850	NN	denotes	Isl1
T16887	31854-31856	DT	denotes	an
T16888	31871-31877	NN	denotes	marker
T16889	31857-31866	JJ	denotes	excellent
T16890	31867-31870	NN	denotes	SAC
T16894	31888-31889	-RRB-	denotes	)
T16895	31889-31890	.	denotes	.
T16896	31890-31983	sentence	denotes	Moreover, Isl1, unlike Slc18a3, is nuclear, which facilitates scoring of Isl1+/Mki67+ cells.
T16897	31891-31899	RB	denotes	Moreover
T16898	31923-31925	VBZ	denotes	is
T16899	31899-31901	,	denotes	,
T16900	31901-31905	NN	denotes	Isl1
T16901	31905-31907	,	denotes	,
T16902	31907-31913	IN	denotes	unlike
T16903	31914-31921	NN	denotes	Slc18a3
T16904	31921-31923	,	denotes	,
T16905	31926-31933	JJ	denotes	nuclear
T16906	31933-31935	,	denotes	,
T16907	31935-31940	WDT	denotes	which
T16908	31941-31952	VBZ	denotes	facilitates
T16909	31953-31960	NN	denotes	scoring
T16910	31961-31963	IN	denotes	of
T16911	31964-31968	NN	denotes	Isl1
T16912	31977-31982	NNS	denotes	cells
T16913	31968-31969	SYM	denotes	+
T16914	31969-31970	HYPH	denotes	/
T16915	31970-31975	NN	denotes	Mki67
T16916	31975-31976	SYM	denotes	+
T16917	31982-31983	.	denotes	.
T16918	31983-32268	sentence	denotes	It is also expressed earlier than Slc18a3, permitting analysis of SACs soon after their birth at ~E15; thus, we could study retina at P0, a time when ectopic division is high in the inner retina and prior to Rb-independent cell cycle exit associated with terminal differentiation [2].
T16919	31984-31986	PRP	denotes	It
T16920	31995-32004	VBN	denotes	expressed
T16921	31987-31989	VBZ	denotes	is
T16922	31990-31994	RB	denotes	also
T16923	32102-32107	VB	denotes	study
T16924	32005-32012	RBR	denotes	earlier
T16925	32013-32017	IN	denotes	than
T16926	32018-32025	NN	denotes	Slc18a3
T16927	32025-32027	,	denotes	,
T16928	32027-32037	VBG	denotes	permitting
T16929	32038-32046	NN	denotes	analysis
T16930	32047-32049	IN	denotes	of
T16931	32050-32054	NNS	denotes	SACs
T16932	32055-32059	RB	denotes	soon
T16933	32060-32065	IN	denotes	after
T16934	32066-32071	PRP$	denotes	their
T16935	32072-32077	NN	denotes	birth
T16936	32078-32080	IN	denotes	at
T16937	32081-32082	SYM	denotes	~
T16938	32082-32085	NN	denotes	E15
T16939	32085-32086	:	denotes	;
T16940	32087-32091	RB	denotes	thus
T16941	32091-32093	,	denotes	,
T16942	32093-32095	PRP	denotes	we
T16943	32096-32101	MD	denotes	could
T16944	32108-32114	NN	denotes	retina
T16945	32115-32117	IN	denotes	at
T16946	32118-32120	NN	denotes	P0
T16947	32120-32122	,	denotes	,
T16948	32122-32123	DT	denotes	a
T16949	32124-32128	NN	denotes	time
T16950	32129-32133	WRB	denotes	when
T16951	32151-32153	VBZ	denotes	is
T16952	32134-32141	JJ	denotes	ectopic
T16953	32142-32150	NN	denotes	division
T16954	32154-32158	JJ	denotes	high
T16955	32159-32161	IN	denotes	in
T16956	32162-32165	DT	denotes	the
T16957	32172-32178	NN	denotes	retina
T16958	32166-32171	JJ	denotes	inner
T16959	32179-32182	CC	denotes	and
T16960	32183-32188	RB	denotes	prior
T16961	32189-32191	IN	denotes	to
T16962	32192-32194	NN	denotes	Rb
T16963	32195-32206	JJ	denotes	independent
T16964	32194-32195	HYPH	denotes	-
T16965	32218-32222	NN	denotes	exit
T16966	32207-32211	NN	denotes	cell
T16967	32212-32217	NN	denotes	cycle
T16968	32223-32233	VBN	denotes	associated
T16969	32234-32238	IN	denotes	with
T16970	32239-32247	JJ	denotes	terminal
T16971	32248-32263	NN	denotes	differentiation
T16972	32264-32265	-LRB-	denotes	[
T16973	32265-32266	CD	denotes	2
T16974	32266-32267	-RRB-	denotes	]
T16975	32267-32268	.	denotes	.
T16976	32268-32453	sentence	denotes	At P0, no WT Isl1+ cells in the inner neuroblastic layer (NBL) (which is the future INL) were dividing, but 57 ± 14 Isl1+/Mki67+ cells were detected in the Rb KO inner NBL (Figure 4D).
T16977	32269-32271	IN	denotes	At
T16978	32363-32371	VBG	denotes	dividing
T16979	32272-32274	NN	denotes	P0
T16980	32274-32276	,	denotes	,
T16981	32276-32278	DT	denotes	no
T16982	32288-32293	NNS	denotes	cells
T16983	32279-32281	NN	denotes	WT
T16984	32282-32286	NN	denotes	Isl1
T16985	32286-32287	SYM	denotes	+
T16986	32294-32296	IN	denotes	in
T16987	32297-32300	DT	denotes	the
T16988	32320-32325	NN	denotes	layer
T16989	32301-32306	JJ	denotes	inner
T16990	32307-32319	JJ	denotes	neuroblastic
T16991	32326-32327	-LRB-	denotes	(
T16992	32327-32330	NN	denotes	NBL
T16993	32330-32331	-RRB-	denotes	)
T16994	32332-32333	-LRB-	denotes	(
T16995	32333-32338	WDT	denotes	which
T16996	32339-32341	VBZ	denotes	is
T16997	32342-32345	DT	denotes	the
T16998	32353-32356	NN	denotes	INL
T16999	32346-32352	JJ	denotes	future
T17000	32356-32357	-RRB-	denotes	)
T17001	32358-32362	VBD	denotes	were
T17002	32371-32373	,	denotes	,
T17003	32373-32376	CC	denotes	but
T17004	32377-32379	CD	denotes	57
T17005	32382-32384	CD	denotes	14
T17006	32380-32381	SYM	denotes	±
T17007	32398-32403	NNS	denotes	cells
T17008	32385-32389	NN	denotes	Isl1
T17009	32389-32390	SYM	denotes	+
T17010	32390-32391	HYPH	denotes	/
T17011	32391-32396	NN	denotes	Mki67
T17012	32396-32397	SYM	denotes	+
T17013	32409-32417	VBN	denotes	detected
T17014	32404-32408	VBD	denotes	were
T17015	32418-32420	IN	denotes	in
T17016	32421-32424	DT	denotes	the
T17017	32437-32440	NN	denotes	NBL
T17018	32425-32427	NN	denotes	Rb
T17019	32428-32430	NN	denotes	KO
T17020	32431-32436	JJ	denotes	inner
T17021	32441-32442	-LRB-	denotes	(
T17022	32449-32451	NN	denotes	4D
T17023	32442-32448	NN	denotes	Figure
T17024	32451-32452	-RRB-	denotes	)
T17025	32452-32453	.	denotes	.
T17026	32453-32635	sentence	denotes	Indeed, about one-third of all Isl1+ cells in the entire inner NBL were dividing in the Rb KO retina, or ~50% in the periphery where Cre is expressed (Figure 4E and data not shown).
T17027	32454-32460	RB	denotes	Indeed
T17028	32526-32534	VBG	denotes	dividing
T17029	32460-32462	,	denotes	,
T17030	32462-32467	IN	denotes	about
T17031	32468-32471	CD	denotes	one
T17032	32471-32472	HYPH	denotes	-
T17033	32472-32477	NN	denotes	third
T17034	32478-32480	IN	denotes	of
T17035	32481-32484	DT	denotes	all
T17036	32491-32496	NNS	denotes	cells
T17037	32485-32489	NN	denotes	Isl1
T17038	32489-32490	SYM	denotes	+
T17039	32497-32499	IN	denotes	in
T17040	32500-32503	DT	denotes	the
T17041	32517-32520	NN	denotes	NBL
T17042	32504-32510	JJ	denotes	entire
T17043	32511-32516	JJ	denotes	inner
T17044	32521-32525	VBD	denotes	were
T17045	32535-32537	IN	denotes	in
T17046	32538-32541	DT	denotes	the
T17047	32548-32554	NN	denotes	retina
T17048	32542-32544	NN	denotes	Rb
T17049	32545-32547	NN	denotes	KO
T17050	32554-32556	,	denotes	,
T17051	32556-32558	CC	denotes	or
T17052	32559-32560	SYM	denotes	~
T17053	32560-32562	CD	denotes	50
T17054	32562-32563	NN	denotes	%
T17055	32564-32566	IN	denotes	in
T17056	32567-32570	DT	denotes	the
T17057	32571-32580	NN	denotes	periphery
T17058	32581-32586	WRB	denotes	where
T17059	32594-32603	VBN	denotes	expressed
T17060	32587-32590	NN	denotes	Cre
T17061	32591-32593	VBZ	denotes	is
T17062	32604-32605	-LRB-	denotes	(
T17063	32612-32614	NN	denotes	4E
T17064	32605-32611	NN	denotes	Figure
T17065	32615-32618	CC	denotes	and
T17066	32619-32623	NNS	denotes	data
T17067	32628-32633	VBN	denotes	shown
T17068	32624-32627	RB	denotes	not
T17069	32633-32634	-RRB-	denotes	)
T17070	32634-32635	.	denotes	.
T17071	32635-32822	sentence	denotes	This defect was suppressed in the Rb/E2f1 DKO retina, where we detected only 1 ± 1 dividing SAC, but not the Rb/E2f3 DKO retina, where there were 53 ± 8 dividing SACs (Figure 4D and 4E).
T17072	32636-32640	DT	denotes	This
T17073	32641-32647	NN	denotes	defect
T17074	32652-32662	VBN	denotes	suppressed
T17075	32648-32651	VBD	denotes	was
T17076	32663-32665	IN	denotes	in
T17077	32666-32669	DT	denotes	the
T17078	32682-32688	NN	denotes	retina
T17079	32670-32672	NN	denotes	Rb
T17080	32673-32677	NN	denotes	E2f1
T17081	32672-32673	HYPH	denotes	/
T17082	32678-32681	NN	denotes	DKO
T17083	32688-32690	,	denotes	,
T17084	32690-32695	WRB	denotes	where
T17085	32699-32707	VBD	denotes	detected
T17086	32696-32698	PRP	denotes	we
T17087	32708-32712	RB	denotes	only
T17088	32717-32718	CD	denotes	1
T17089	32713-32714	CD	denotes	1
T17090	32715-32716	SYM	denotes	±
T17091	32728-32731	NN	denotes	SAC
T17092	32719-32727	NN	denotes	dividing
T17093	32731-32733	,	denotes	,
T17094	32733-32736	CC	denotes	but
T17095	32737-32740	RB	denotes	not
T17096	32741-32744	DT	denotes	the
T17097	32757-32763	NN	denotes	retina
T17098	32745-32747	NN	denotes	Rb
T17099	32748-32752	NN	denotes	E2f3
T17100	32747-32748	HYPH	denotes	/
T17101	32753-32756	NN	denotes	DKO
T17102	32763-32765	,	denotes	,
T17103	32765-32770	WRB	denotes	where
T17104	32777-32781	VBD	denotes	were
T17105	32771-32776	EX	denotes	there
T17106	32782-32784	CD	denotes	53
T17107	32787-32788	CD	denotes	8
T17108	32785-32786	SYM	denotes	±
T17109	32798-32802	NNS	denotes	SACs
T17110	32789-32797	VBG	denotes	dividing
T17111	32803-32804	-LRB-	denotes	(
T17112	32811-32813	NN	denotes	4D
T17113	32804-32810	NN	denotes	Figure
T17114	32814-32817	CC	denotes	and
T17115	32818-32820	NN	denotes	4E
T17116	32820-32821	-RRB-	denotes	)
T17117	32821-32822	.	denotes	.
T17118	32822-32936	sentence	denotes	We observed similar effects at P0 with Calb2, which marks newborn SACs and other amacrine cells (data not shown).
T17119	32823-32825	PRP	denotes	We
T17120	32826-32834	VBD	denotes	observed
T17121	32835-32842	JJ	denotes	similar
T17122	32843-32850	NNS	denotes	effects
T17123	32851-32853	IN	denotes	at
T17124	32854-32856	NN	denotes	P0
T17125	32857-32861	IN	denotes	with
T17126	32862-32867	NN	denotes	Calb2
T17127	32867-32869	,	denotes	,
T17128	32869-32874	WDT	denotes	which
T17129	32875-32880	VBZ	denotes	marks
T17130	32881-32888	JJ	denotes	newborn
T17131	32889-32893	NNS	denotes	SACs
T17132	32894-32897	CC	denotes	and
T17133	32898-32903	JJ	denotes	other
T17134	32913-32918	NNS	denotes	cells
T17135	32904-32912	JJ	denotes	amacrine
T17136	32919-32920	-LRB-	denotes	(
T17137	32929-32934	VBN	denotes	shown
T17138	32920-32924	NNS	denotes	data
T17139	32925-32928	RB	denotes	not
T17140	32934-32935	-RRB-	denotes	)
T17141	32935-32936	.	denotes	.
T17142	32936-33117	sentence	denotes	Thus, in Rb KO SACs, E2f1 deletion suppresses ectopic division but not aberrant differentiation, whereas E2f3 deletion suppresses aberrant differentiation but not ectopic division.
T17143	32937-32941	RB	denotes	Thus
T17144	32972-32982	VBZ	denotes	suppresses
T17145	32941-32943	,	denotes	,
T17146	32943-32945	IN	denotes	in
T17147	32946-32948	NN	denotes	Rb
T17148	32949-32951	NN	denotes	KO
T17149	32952-32956	NNS	denotes	SACs
T17150	32956-32958	,	denotes	,
T17151	32958-32962	NN	denotes	E2f1
T17152	32963-32971	NN	denotes	deletion
T17153	32983-32990	JJ	denotes	ectopic
T17154	32991-32999	NN	denotes	division
T17155	33000-33003	CC	denotes	but
T17156	33004-33007	RB	denotes	not
T17157	33008-33016	JJ	denotes	aberrant
T17158	33017-33032	NN	denotes	differentiation
T17159	33032-33034	,	denotes	,
T17160	33034-33041	IN	denotes	whereas
T17161	33056-33066	VBZ	denotes	suppresses
T17162	33042-33046	NN	denotes	E2f3
T17163	33047-33055	NN	denotes	deletion
T17164	33067-33075	JJ	denotes	aberrant
T17165	33076-33091	NN	denotes	differentiation
T17166	33092-33095	CC	denotes	but
T17167	33096-33099	RB	denotes	not
T17168	33100-33107	JJ	denotes	ectopic
T17169	33108-33116	NN	denotes	division
T17170	33116-33117	.	denotes	.
T23464	45540-45543	NN	denotes	rod
T18365	33119-33127	JJ	denotes	Specific
T18366	33128-33138	NN	denotes	Expression
T18367	33139-33141	IN	denotes	of
T18368	33142-33146	NN	denotes	E2f3
T18369	33147-33149	IN	denotes	in
T18370	33150-33154	NNS	denotes	SACs
T18371	33155-33158	CC	denotes	and
T18372	33159-33164	JJ	denotes	Other
T18373	33165-33172	NNS	denotes	Subsets
T18374	33173-33175	IN	denotes	of
T18375	33176-33179	NN	denotes	CNS
T18376	33180-33187	NNS	denotes	Neurons
T18377	33187-33371	sentence	denotes	The unique effect of E2f3 in disrupting the differentiation of SACs but not other retinal neurons might be due to cell-type-specific expression or cell-type-specific activity of E2f3.
T18378	33188-33191	DT	denotes	The
T18379	33199-33205	NN	denotes	effect
T18380	33192-33198	JJ	denotes	unique
T18381	33292-33294	VB	denotes	be
T18382	33206-33208	IN	denotes	of
T18383	33209-33213	NN	denotes	E2f3
T18384	33214-33216	IN	denotes	in
T18385	33217-33227	VBG	denotes	disrupting
T18386	33228-33231	DT	denotes	the
T18387	33232-33247	NN	denotes	differentiation
T18388	33248-33250	IN	denotes	of
T18389	33251-33255	NNS	denotes	SACs
T18390	33256-33259	CC	denotes	but
T18391	33260-33263	RB	denotes	not
T18392	33264-33269	JJ	denotes	other
T18393	33278-33285	NNS	denotes	neurons
T18394	33270-33277	JJ	denotes	retinal
T18395	33286-33291	MD	denotes	might
T18396	33295-33298	IN	denotes	due
T18397	33299-33301	IN	denotes	to
T18398	33302-33306	NN	denotes	cell
T18399	33307-33311	NN	denotes	type
T18400	33306-33307	HYPH	denotes	-
T18401	33312-33320	JJ	denotes	specific
T18402	33311-33312	HYPH	denotes	-
T18403	33321-33331	NN	denotes	expression
T18404	33332-33334	CC	denotes	or
T18405	33335-33339	NN	denotes	cell
T18406	33340-33344	NN	denotes	type
T18407	33339-33340	HYPH	denotes	-
T18408	33345-33353	JJ	denotes	specific
T18409	33344-33345	HYPH	denotes	-
T18410	33354-33362	NN	denotes	activity
T18411	33363-33365	IN	denotes	of
T18412	33366-33370	NN	denotes	E2f3
T18413	33370-33371	.	denotes	.
T18414	33371-33483	sentence	denotes	Determining between these two possibilities is not easy, as E2f immunostaining in mouse tissues is problematic.
T18415	33372-33383	VBG	denotes	Determining
T18416	33416-33418	VBZ	denotes	is
T18417	33384-33391	IN	denotes	between
T18418	33392-33397	DT	denotes	these
T18419	33402-33415	NNS	denotes	possibilities
T18420	33398-33401	CD	denotes	two
T18421	33419-33422	RB	denotes	not
T18422	33423-33427	JJ	denotes	easy
T18423	33427-33429	,	denotes	,
T18424	33429-33431	IN	denotes	as
T18425	33468-33470	VBZ	denotes	is
T18426	33432-33435	NN	denotes	E2f
T18427	33436-33450	NN	denotes	immunostaining
T18428	33451-33453	IN	denotes	in
T18429	33454-33459	NN	denotes	mouse
T18430	33460-33467	NNS	denotes	tissues
T18431	33471-33482	JJ	denotes	problematic
T18432	33482-33483	.	denotes	.
T18433	33483-33613	sentence	denotes	We did not solve this issue for E2f1 or E2f2, but used a modified protocol [50] to successfully track E2f3 expression (Figure 5).
T18434	33484-33486	PRP	denotes	We
T18435	33495-33500	VB	denotes	solve
T18436	33487-33490	VBD	denotes	did
T18437	33491-33494	RB	denotes	not
T18438	33501-33505	DT	denotes	this
T18439	33506-33511	NN	denotes	issue
T18440	33512-33515	IN	denotes	for
T18441	33516-33520	NN	denotes	E2f1
T18442	33521-33523	CC	denotes	or
T18443	33524-33528	NN	denotes	E2f2
T18444	33528-33530	,	denotes	,
T18445	33530-33533	CC	denotes	but
T18446	33534-33538	VBD	denotes	used
T18447	33539-33540	DT	denotes	a
T18448	33550-33558	NN	denotes	protocol
T18449	33541-33549	VBN	denotes	modified
T18450	33559-33560	-LRB-	denotes	[
T18451	33560-33562	CD	denotes	50
T18452	33562-33563	-RRB-	denotes	]
T18453	33564-33566	TO	denotes	to
T18454	33580-33585	VB	denotes	track
T18455	33567-33579	RB	denotes	successfully
T18456	33586-33590	NN	denotes	E2f3
T18457	33591-33601	NN	denotes	expression
T18458	33602-33603	-LRB-	denotes	(
T18459	33603-33609	NN	denotes	Figure
T18460	33610-33611	CD	denotes	5
T18461	33611-33612	-RRB-	denotes	)
T18462	33612-33613	.	denotes	.
T18463	33613-33716	sentence	denotes	At P0, E2f3 was detected in RPCs, consistent with a putative role in normal proliferation (Figure 5A).
T18464	33614-33616	IN	denotes	At
T18465	33630-33638	VBN	denotes	detected
T18466	33617-33619	NN	denotes	P0
T18467	33619-33621	,	denotes	,
T18468	33621-33625	NN	denotes	E2f3
T18469	33626-33629	VBD	denotes	was
T18470	33639-33641	IN	denotes	in
T18471	33642-33646	NNS	denotes	RPCs
T18472	33646-33648	,	denotes	,
T18473	33648-33658	JJ	denotes	consistent
T18474	33659-33663	IN	denotes	with
T18475	33664-33665	DT	denotes	a
T18476	33675-33679	NN	denotes	role
T18477	33666-33674	JJ	denotes	putative
T18478	33680-33682	IN	denotes	in
T18479	33683-33689	JJ	denotes	normal
T18480	33690-33703	NN	denotes	proliferation
T18481	33704-33705	-LRB-	denotes	(
T18482	33712-33714	NN	denotes	5A
T18483	33705-33711	NN	denotes	Figure
T18484	33714-33715	-RRB-	denotes	)
T18485	33715-33716	.	denotes	.
T18486	33716-33803	sentence	denotes	The signal was specific as it was absent in the E2f3 KO peripheral retina (Figure 5A).
T18487	33717-33720	DT	denotes	The
T18488	33721-33727	NN	denotes	signal
T18489	33728-33731	VBD	denotes	was
T18490	33732-33740	JJ	denotes	specific
T18491	33741-33743	IN	denotes	as
T18492	33747-33750	VBD	denotes	was
T18493	33744-33746	PRP	denotes	it
T18494	33751-33757	JJ	denotes	absent
T18495	33758-33760	IN	denotes	in
T18496	33761-33764	DT	denotes	the
T18497	33784-33790	NN	denotes	retina
T18498	33765-33769	NN	denotes	E2f3
T18499	33770-33772	NN	denotes	KO
T18500	33773-33783	JJ	denotes	peripheral
T18501	33791-33792	-LRB-	denotes	(
T18502	33799-33801	NN	denotes	5A
T18503	33792-33798	NN	denotes	Figure
T18504	33801-33802	-RRB-	denotes	)
T18505	33802-33803	.	denotes	.
T18506	33803-34029	sentence	denotes	As the retina differentiated and RPC division diminished, the number of E2f3+ cells also dropped, and by P8, when division is virtually over, only a subset of post-mitotic cells in the inner retina expressed E2f3 (Figure 5A).
T18507	33804-33806	IN	denotes	As
T18508	33818-33832	VBN	denotes	differentiated
T18509	33807-33810	DT	denotes	the
T18510	33811-33817	NN	denotes	retina
T18511	33893-33900	VBD	denotes	dropped
T18512	33833-33836	CC	denotes	and
T18513	33837-33840	NN	denotes	RPC
T18514	33841-33849	NN	denotes	division
T18515	33850-33860	VBD	denotes	diminished
T18516	33860-33862	,	denotes	,
T18517	33862-33865	DT	denotes	the
T18518	33866-33872	NN	denotes	number
T18519	33873-33875	IN	denotes	of
T18520	33876-33880	NN	denotes	E2f3
T18521	33882-33887	NNS	denotes	cells
T18522	33880-33881	SYM	denotes	+
T18523	33888-33892	RB	denotes	also
T18524	33900-33902	,	denotes	,
T18525	33902-33905	CC	denotes	and
T18526	33906-33908	IN	denotes	by
T18527	34002-34011	VBD	denotes	expressed
T18528	33909-33911	NN	denotes	P8
T18529	33911-33913	,	denotes	,
T18530	33913-33917	WRB	denotes	when
T18531	33927-33929	VBZ	denotes	is
T18532	33918-33926	NN	denotes	division
T18533	33930-33939	RB	denotes	virtually
T18534	33940-33944	RB	denotes	over
T18535	33944-33946	,	denotes	,
T18536	33946-33950	RB	denotes	only
T18537	33953-33959	NN	denotes	subset
T18538	33951-33952	DT	denotes	a
T18539	33960-33962	IN	denotes	of
T18540	33963-33975	JJ	denotes	post-mitotic
T18541	33976-33981	NNS	denotes	cells
T18542	33982-33984	IN	denotes	in
T18543	33985-33988	DT	denotes	the
T18544	33995-34001	NN	denotes	retina
T18545	33989-33994	JJ	denotes	inner
T18546	34012-34016	NN	denotes	E2f3
T18547	34017-34018	-LRB-	denotes	(
T18548	34025-34027	NN	denotes	5A
T18549	34018-34024	NN	denotes	Figure
T18550	34027-34028	-RRB-	denotes	)
T18551	34028-34029	.	denotes	.
T18552	34029-34181	sentence	denotes	By P18, E2f3 was also detected in two tracks in the IPL (Figure 5A and 5B), reminiscent of SAC markers such as Chat and Slc18a3 (c.f. Figures 3 and 4).
T18553	34030-34032	IN	denotes	By
T18554	34052-34060	VBN	denotes	detected
T18555	34033-34036	NN	denotes	P18
T18556	34036-34038	,	denotes	,
T18557	34038-34042	NN	denotes	E2f3
T18558	34043-34046	VBD	denotes	was
T18559	34047-34051	RB	denotes	also
T18560	34061-34063	IN	denotes	in
T18561	34064-34067	CD	denotes	two
T18562	34068-34074	NNS	denotes	tracks
T18563	34075-34077	IN	denotes	in
T18564	34078-34081	DT	denotes	the
T18565	34082-34085	NN	denotes	IPL
T18566	34086-34087	-LRB-	denotes	(
T18567	34094-34096	NN	denotes	5A
T18568	34087-34093	NN	denotes	Figure
T18569	34097-34100	CC	denotes	and
T18570	34101-34103	NN	denotes	5B
T18571	34103-34104	-RRB-	denotes	)
T18572	34104-34106	,	denotes	,
T18573	34106-34117	JJ	denotes	reminiscent
T18574	34118-34120	IN	denotes	of
T18575	34121-34124	NN	denotes	SAC
T18576	34125-34132	NNS	denotes	markers
T18577	34133-34137	JJ	denotes	such
T18578	34138-34140	IN	denotes	as
T18579	34141-34145	NN	denotes	Chat
T18580	34146-34149	CC	denotes	and
T18581	34150-34157	NN	denotes	Slc18a3
T18582	34158-34159	-LRB-	denotes	(
T18583	34172-34173	CD	denotes	3
T18584	34159-34163	FW	denotes	c.f.
T18585	34164-34171	NNS	denotes	Figures
T18586	34174-34177	CC	denotes	and
T18587	34178-34179	CD	denotes	4
T18588	34179-34180	-RRB-	denotes	)
T18589	34180-34181	.	denotes	.
T18590	34181-34322	sentence	denotes	This cytoplasmic E2f3 staining was also specific, as it was absent in the E2f3 KO peripheral retina of α-Cre;E2f3loxP/loxP mice (Figure 5A).
T18591	34182-34186	DT	denotes	This
T18592	34204-34212	NN	denotes	staining
T18593	34187-34198	JJ	denotes	cytoplasmic
T18594	34199-34203	NN	denotes	E2f3
T18595	34213-34216	VBD	denotes	was
T18596	34217-34221	RB	denotes	also
T18597	34222-34230	JJ	denotes	specific
T18598	34230-34232	,	denotes	,
T18599	34232-34234	IN	denotes	as
T18600	34238-34241	VBD	denotes	was
T18601	34235-34237	PRP	denotes	it
T18602	34242-34248	JJ	denotes	absent
T18603	34249-34251	IN	denotes	in
T18604	34252-34255	DT	denotes	the
T18605	34275-34281	NN	denotes	retina
T18606	34256-34260	NN	denotes	E2f3
T18607	34261-34263	NN	denotes	KO
T18608	34264-34274	JJ	denotes	peripheral
T18609	34282-34284	IN	denotes	of
T18610	34285-34286	NN	denotes	α
T18611	34287-34290	NN	denotes	Cre
T18612	34286-34287	HYPH	denotes	-
T18613	34305-34309	NNS	denotes	mice
T18614	34290-34291	:	denotes	;
T18615	34291-34299	NN	denotes	E2f3loxP
T18616	34300-34304	NN	denotes	loxP
T18617	34299-34300	HYPH	denotes	/
T18618	34310-34311	-LRB-	denotes	(
T18619	34318-34320	NN	denotes	5A
T18620	34311-34317	NN	denotes	Figure
T18621	34320-34321	-RRB-	denotes	)
T18622	34321-34322	.	denotes	.
T18623	34322-34468	sentence	denotes	Indeed, double labelling with E2f3 (red) and Chat plus Slc18a3 (green) confirmed that E2f3 is present in both SAC soma and dendrites (Figure 5B).
T18624	34323-34329	RB	denotes	Indeed
T18625	34394-34403	VBD	denotes	confirmed
T18626	34329-34331	,	denotes	,
T18627	34331-34337	JJ	denotes	double
T18628	34338-34347	NN	denotes	labelling
T18629	34348-34352	IN	denotes	with
T18630	34353-34357	NN	denotes	E2f3
T18631	34358-34359	-LRB-	denotes	(
T18632	34359-34362	JJ	denotes	red
T18633	34362-34363	-RRB-	denotes	)
T18634	34364-34367	CC	denotes	and
T18635	34368-34372	NN	denotes	Chat
T18636	34373-34377	CC	denotes	plus
T18637	34378-34385	NN	denotes	Slc18a3
T18638	34386-34387	-LRB-	denotes	(
T18639	34387-34392	JJ	denotes	green
T18640	34392-34393	-RRB-	denotes	)
T18641	34404-34408	IN	denotes	that
T18642	34414-34416	VBZ	denotes	is
T18643	34409-34413	NN	denotes	E2f3
T18644	34417-34424	JJ	denotes	present
T18645	34425-34427	IN	denotes	in
T18646	34428-34432	CC	denotes	both
T18647	34437-34441	NN	denotes	soma
T18648	34433-34436	NN	denotes	SAC
T18649	34442-34445	CC	denotes	and
T18650	34446-34455	NNS	denotes	dendrites
T18651	34456-34457	-LRB-	denotes	(
T18652	34464-34466	NN	denotes	5B
T18653	34457-34463	NN	denotes	Figure
T18654	34466-34467	-RRB-	denotes	)
T18655	34467-34468	.	denotes	.
T18656	34468-34674	sentence	denotes	Rb protein was also detected in the inner retina (Figure 5A), and showed a similar distribution as E2f3 in SACs (Figure 5B), and was also present in mature ganglion cells and Müller cells as reported [51].
T18657	34469-34471	NN	denotes	Rb
T18658	34472-34479	NN	denotes	protein
T18659	34489-34497	VBN	denotes	detected
T18660	34480-34483	VBD	denotes	was
T18661	34484-34488	RB	denotes	also
T18662	34498-34500	IN	denotes	in
T18663	34501-34504	DT	denotes	the
T18664	34511-34517	NN	denotes	retina
T18665	34505-34510	JJ	denotes	inner
T18666	34518-34519	-LRB-	denotes	(
T18667	34526-34528	NN	denotes	5A
T18668	34519-34525	NN	denotes	Figure
T18669	34528-34529	-RRB-	denotes	)
T18670	34529-34531	,	denotes	,
T18671	34531-34534	CC	denotes	and
T18672	34535-34541	VBD	denotes	showed
T18673	34542-34543	DT	denotes	a
T18674	34552-34564	NN	denotes	distribution
T18675	34544-34551	JJ	denotes	similar
T18676	34565-34567	IN	denotes	as
T18677	34568-34572	NN	denotes	E2f3
T18678	34573-34575	IN	denotes	in
T18679	34576-34580	NNS	denotes	SACs
T18680	34581-34582	-LRB-	denotes	(
T18681	34589-34591	NN	denotes	5B
T18682	34582-34588	NN	denotes	Figure
T18683	34591-34592	-RRB-	denotes	)
T18684	34592-34594	,	denotes	,
T18685	34594-34597	CC	denotes	and
T18686	34598-34601	VBD	denotes	was
T18687	34602-34606	RB	denotes	also
T18688	34607-34614	JJ	denotes	present
T18689	34615-34617	IN	denotes	in
T18690	34618-34624	JJ	denotes	mature
T18691	34634-34639	NNS	denotes	cells
T18692	34625-34633	NN	denotes	ganglion
T18693	34640-34643	CC	denotes	and
T18694	34644-34650	NN	denotes	Müller
T18695	34651-34656	NNS	denotes	cells
T18696	34657-34659	IN	denotes	as
T18697	34660-34668	VBN	denotes	reported
T18698	34669-34670	-LRB-	denotes	[
T18699	34670-34672	CD	denotes	51
T18700	34672-34673	-RRB-	denotes	]
T18701	34673-34674	.	denotes	.
T18702	34674-34796	sentence	denotes	Rb staining in SAC processes was specific as it was absent in the peripheral retina of αCre;RbloxP/loxP mice (Figure 5A).
T18703	34675-34677	NN	denotes	Rb
T18704	34678-34686	NN	denotes	staining
T18705	34704-34707	VBD	denotes	was
T18706	34687-34689	IN	denotes	in
T18707	34690-34693	NN	denotes	SAC
T18708	34694-34703	NNS	denotes	processes
T18709	34708-34716	JJ	denotes	specific
T18710	34717-34719	IN	denotes	as
T18711	34723-34726	VBD	denotes	was
T18712	34720-34722	PRP	denotes	it
T18713	34727-34733	JJ	denotes	absent
T18714	34734-34736	IN	denotes	in
T18715	34737-34740	DT	denotes	the
T18779	35883-35888	VBN	denotes	shown
T18780	35874-35878	NNS	denotes	data
T18781	35879-35882	RB	denotes	not
T18782	35888-35889	-RRB-	denotes	)
T18783	35889-35890	.	denotes	.
T18784	35890-36098	sentence	denotes	For example, in the P20 amygdala, E2f3 colocalized with the general neuronal markers Mtap2 and Mecp2 [52], but not with Calb2, which marks a subset of neurons, or with the glial marker Gfap (data not shown).
T18785	35891-35894	IN	denotes	For
T18786	35930-35941	VBD	denotes	colocalized
T18787	35895-35902	NN	denotes	example
T18788	35902-35904	,	denotes	,
T18789	35904-35906	IN	denotes	in
T18790	35907-35910	DT	denotes	the
T18791	35915-35923	NN	denotes	amygdala
T18792	35911-35914	NN	denotes	P20
T18793	35923-35925	,	denotes	,
T18794	35925-35929	NN	denotes	E2f3
T18795	35942-35946	IN	denotes	with
T18796	35947-35950	DT	denotes	the
T18797	35968-35975	NNS	denotes	markers
T18798	35951-35958	JJ	denotes	general
T18799	35959-35967	JJ	denotes	neuronal
T18800	35976-35981	NN	denotes	Mtap2
T18801	35982-35985	CC	denotes	and
T18802	35986-35991	NN	denotes	Mecp2
T18803	35992-35993	-LRB-	denotes	[
T18804	35993-35995	CD	denotes	52
T18805	35995-35996	-RRB-	denotes	]
T18806	35996-35998	,	denotes	,
T18807	35998-36001	CC	denotes	but
T18808	36002-36005	RB	denotes	not
T18809	36006-36010	IN	denotes	with
T18810	36011-36016	NN	denotes	Calb2
T18811	36016-36018	,	denotes	,
T18812	36018-36023	WDT	denotes	which
T18813	36024-36029	VBZ	denotes	marks
T18814	36030-36031	DT	denotes	a
T18815	36032-36038	NN	denotes	subset
T18816	36039-36041	IN	denotes	of
T18817	36042-36049	NNS	denotes	neurons
T18818	36049-36051	,	denotes	,
T18819	36051-36053	CC	denotes	or
T18820	36054-36058	IN	denotes	with
T18821	36059-36062	DT	denotes	the
T18822	36069-36075	NN	denotes	marker
T18823	36063-36068	JJ	denotes	glial
T18824	36076-36080	NN	denotes	Gfap
T18825	36081-36082	-LRB-	denotes	(
T18826	36091-36096	VBN	denotes	shown
T18827	36082-36086	NNS	denotes	data
T18828	36087-36090	RB	denotes	not
T18829	36096-36097	-RRB-	denotes	)
T18830	36097-36098	.	denotes	.
T18831	36098-36262	sentence	denotes	Unlike in retinal SACs, E2f3 was not coexpressed in Chat+ or Slc18a3+ cholinergic neurons located in various regions of the brain and spinal cord (data not shown).
T18832	36099-36105	IN	denotes	Unlike
T18833	36136-36147	VBN	denotes	coexpressed
T18834	36106-36108	IN	denotes	in
T18835	36109-36116	JJ	denotes	retinal
T18836	36117-36121	NNS	denotes	SACs
T18837	36121-36123	,	denotes	,
T18838	36123-36127	NN	denotes	E2f3
T18839	36128-36131	VBD	denotes	was
T18840	36132-36135	RB	denotes	not
T18841	36148-36150	IN	denotes	in
T18842	36151-36155	NN	denotes	Chat
T18843	36181-36188	NNS	denotes	neurons
T18844	36155-36156	SYM	denotes	+
T18845	36157-36159	CC	denotes	or
T18846	36160-36167	NN	denotes	Slc18a3
T18847	36167-36168	SYM	denotes	+
T18848	36169-36180	JJ	denotes	cholinergic
T18849	36189-36196	VBN	denotes	located
T18850	36197-36199	IN	denotes	in
T18851	36200-36207	JJ	denotes	various
T18852	36208-36215	NNS	denotes	regions
T18853	36216-36218	IN	denotes	of
T18854	36219-36222	DT	denotes	the
T18855	36223-36228	NN	denotes	brain
T18856	36229-36232	CC	denotes	and
T18857	36233-36239	JJ	denotes	spinal
T18858	36240-36244	NN	denotes	cord
T18859	36245-36246	-LRB-	denotes	(
T18860	36255-36260	VBN	denotes	shown
T18861	36246-36250	NNS	denotes	data
T18862	36251-36254	RB	denotes	not
T18863	36260-36261	-RRB-	denotes	)
T18864	36261-36262	.	denotes	.
T18865	36262-36473	sentence	denotes	In agreement, we could not detect defects in cholinergic Rb KO neurons in the developing forebrain, but other Rb KO neurons in this region showed differentiation defects that were rescued by deleting E2f3 [53].
T18866	36263-36265	IN	denotes	In
T18867	36290-36296	VB	denotes	detect
T18868	36266-36275	NN	denotes	agreement
T18869	36275-36277	,	denotes	,
T18870	36277-36279	PRP	denotes	we
T18871	36280-36285	MD	denotes	could
T18872	36286-36289	RB	denotes	not
T18873	36297-36304	NNS	denotes	defects
T18874	36305-36307	IN	denotes	in
T18875	36308-36319	JJ	denotes	cholinergic
T18876	36326-36333	NNS	denotes	neurons
T18877	36320-36322	NN	denotes	Rb
T18878	36323-36325	NN	denotes	KO
T18879	36334-36336	IN	denotes	in
T18880	36337-36340	DT	denotes	the
T18881	36352-36361	NN	denotes	forebrain
T18882	36341-36351	VBG	denotes	developing
T18883	36361-36363	,	denotes	,
T18884	36363-36366	CC	denotes	but
T18885	36367-36372	JJ	denotes	other
T18886	36379-36386	NNS	denotes	neurons
T18887	36373-36375	NN	denotes	Rb
T18888	36376-36378	NN	denotes	KO
T18889	36402-36408	VBD	denotes	showed
T18890	36387-36389	IN	denotes	in
T18891	36390-36394	DT	denotes	this
T18892	36395-36401	NN	denotes	region
T18893	36409-36424	NN	denotes	differentiation
T18894	36425-36432	NNS	denotes	defects
T18895	36433-36437	WDT	denotes	that
T18896	36443-36450	VBN	denotes	rescued
T18897	36438-36442	VBD	denotes	were
T18898	36451-36453	IN	denotes	by
T18899	36454-36462	VBG	denotes	deleting
T18900	36463-36467	NN	denotes	E2f3
T18901	36468-36469	-LRB-	denotes	[
T18902	36469-36471	CD	denotes	53
T18903	36471-36472	-RRB-	denotes	]
T18904	36472-36473	.	denotes	.
T18905	36473-36603	sentence	denotes	Together, these results suggest that the common mechanism by which Rb promotes neural differentiation is through E2f3 inhibition.
T18906	36474-36482	RB	denotes	Together
T18907	36498-36505	VBP	denotes	suggest
T18908	36482-36484	,	denotes	,
T18909	36484-36489	DT	denotes	these
T18910	36490-36497	NNS	denotes	results
T18911	36506-36510	IN	denotes	that
T18912	36576-36578	VBZ	denotes	is
T18913	36511-36514	DT	denotes	the
T18914	36522-36531	NN	denotes	mechanism
T18915	36515-36521	JJ	denotes	common
T18916	36532-36534	IN	denotes	by
T18917	36544-36552	VBZ	denotes	promotes
T18918	36535-36540	WDT	denotes	which
T18919	36541-36543	NN	denotes	Rb
T18920	36553-36559	JJ	denotes	neural
T18921	36560-36575	NN	denotes	differentiation
T18922	36579-36586	IN	denotes	through
T18923	36587-36591	NN	denotes	E2f3
T18924	36592-36602	NN	denotes	inhibition
T18925	36602-36603	.	denotes	.
T23465	45544-45551	JJ	denotes	bipolar
T20216	36605-36613	JJ	denotes	Distinct
T20217	36614-36626	NN	denotes	Localization
T20218	36627-36629	IN	denotes	of
T20219	36630-36634	NN	denotes	E2f3
T20220	36635-36643	NNS	denotes	Isoforms
T20221	36643-36741	sentence	denotes	As noted above, E2f3 and Rb staining in SACs was both nuclear and cytoplasmic (Figure 5A and 5B).
T20222	36644-36646	IN	denotes	As
T20223	36647-36652	VBN	denotes	noted
T20224	36689-36692	VBD	denotes	was
T20225	36653-36658	RB	denotes	above
T20226	36658-36660	,	denotes	,
T20227	36660-36664	NN	denotes	E2f3
T20228	36672-36680	NN	denotes	staining
T20229	36665-36668	CC	denotes	and
T20230	36669-36671	NN	denotes	Rb
T20231	36681-36683	IN	denotes	in
T20232	36684-36688	NNS	denotes	SACs
T20233	36693-36697	CC	denotes	both
T20234	36698-36705	JJ	denotes	nuclear
T20235	36706-36709	CC	denotes	and
T20236	36710-36721	JJ	denotes	cytoplasmic
T20237	36722-36723	-LRB-	denotes	(
T20238	36730-36732	NN	denotes	5A
T20239	36723-36729	NN	denotes	Figure
T20240	36733-36736	CC	denotes	and
T20241	36737-36739	NN	denotes	5B
T20242	36739-36740	-RRB-	denotes	)
T20243	36740-36741	.	denotes	.
T20244	36741-36860	sentence	denotes	The antibody that worked in immunostaining recognizes a C-terminal region and thus, does not distinguish a/b isoforms.
T20245	36742-36745	DT	denotes	The
T20246	36746-36754	NN	denotes	antibody
T20247	36785-36795	VBZ	denotes	recognizes
T20248	36755-36759	WDT	denotes	that
T20249	36760-36766	VBD	denotes	worked
T20250	36767-36769	IN	denotes	in
T20251	36770-36784	NN	denotes	immunostaining
T20252	36796-36797	DT	denotes	a
T20253	36809-36815	NN	denotes	region
T20254	36798-36799	NN	denotes	C
T20255	36800-36808	JJ	denotes	terminal
T20256	36799-36800	HYPH	denotes	-
T20257	36816-36819	CC	denotes	and
T20258	36820-36824	RB	denotes	thus
T20259	36835-36846	VB	denotes	distinguish
T20260	36824-36826	,	denotes	,
T20261	36826-36830	VBZ	denotes	does
T20262	36831-36834	RB	denotes	not
T20263	36847-36848	NN	denotes	a
T20264	36849-36850	NN	denotes	b
T20265	36848-36849	HYPH	denotes	/
T20266	36851-36859	NNS	denotes	isoforms
T20267	36859-36860	.	denotes	.
T20268	36860-36962	sentence	denotes	To our knowledge, the subcellular location of E2f3 isoforms has not been determined in any cell type.
T20269	36861-36863	IN	denotes	To
T20270	36934-36944	VBN	denotes	determined
T20271	36864-36867	PRP$	denotes	our
T20272	36868-36877	NN	denotes	knowledge
T20273	36877-36879	,	denotes	,
T20274	36879-36882	DT	denotes	the
T20275	36895-36903	NN	denotes	location
T20276	36883-36894	JJ	denotes	subcellular
T20277	36904-36906	IN	denotes	of
T20278	36907-36911	NN	denotes	E2f3
T20279	36912-36920	NNS	denotes	isoforms
T20280	36921-36924	VBZ	denotes	has
T20281	36925-36928	RB	denotes	not
T20282	36929-36933	VBN	denotes	been
T20283	36945-36947	IN	denotes	in
T20284	36948-36951	DT	denotes	any
T20285	36957-36961	NN	denotes	type
T20286	36952-36956	NN	denotes	cell
T20287	36961-36962	.	denotes	.
T20288	36962-37156	sentence	denotes	To verify the dual locations of E2f3 and to determine which isoforms were present in retina, we analyzed nuclear and cytoplasmic fractions by Western blot at different times during development.
T20289	36963-36965	TO	denotes	To
T20290	36966-36972	VB	denotes	verify
T20291	37059-37067	VBD	denotes	analyzed
T20292	36973-36976	DT	denotes	the
T20293	36982-36991	NNS	denotes	locations
T20294	36977-36981	JJ	denotes	dual
T20295	36992-36994	IN	denotes	of
T20296	36995-36999	NN	denotes	E2f3
T20297	37000-37003	CC	denotes	and
T20298	37004-37006	TO	denotes	to
T20299	37007-37016	VB	denotes	determine
T20300	37017-37022	WDT	denotes	which
T20301	37023-37031	NNS	denotes	isoforms
T20302	37032-37036	VBD	denotes	were
T20303	37037-37044	JJ	denotes	present
T20304	37045-37047	IN	denotes	in
T20305	37048-37054	NN	denotes	retina
T20306	37054-37056	,	denotes	,
T20307	37056-37058	PRP	denotes	we
T20308	37068-37075	JJ	denotes	nuclear
T20309	37092-37101	NNS	denotes	fractions
T20310	37076-37079	CC	denotes	and
T20311	37080-37091	JJ	denotes	cytoplasmic
T20312	37102-37104	IN	denotes	by
T20313	37105-37112	NNP	denotes	Western
T20314	37113-37117	NN	denotes	blot
T20315	37118-37120	IN	denotes	at
T20316	37121-37130	JJ	denotes	different
T20317	37131-37136	NNS	denotes	times
T20318	37137-37143	IN	denotes	during
T20319	37144-37155	NN	denotes	development
T20320	37155-37156	.	denotes	.
T20321	37156-37300	sentence	denotes	Analysis with the pan-E2f3 antibody (sc-878, Santa Cruz Biotechnology) detected a 55-kD E2f3a species and a 40-kD E2f3b polypeptide (Figure 6).
T20322	37157-37165	NN	denotes	Analysis
T20323	37228-37236	VBD	denotes	detected
T20324	37166-37170	IN	denotes	with
T20325	37171-37174	DT	denotes	the
T20326	37184-37192	NN	denotes	antibody
T20327	37175-37183	JJ	denotes	pan-E2f3
T20328	37193-37194	-LRB-	denotes	(
T20329	37194-37196	NN	denotes	sc
T20330	37196-37197	HYPH	denotes	-
T20331	37197-37200	CD	denotes	878
T20332	37200-37202	,	denotes	,
T20333	37213-37226	NNP	denotes	Biotechnology
T20334	37202-37207	NNP	denotes	Santa
T20335	37208-37212	NNP	denotes	Cruz
T20336	37226-37227	-RRB-	denotes	)
T20337	37237-37238	DT	denotes	a
T20338	37251-37258	NNS	denotes	species
T20339	37239-37241	CD	denotes	55
T20340	37242-37244	NN	denotes	kD
T20341	37241-37242	HYPH	denotes	-
T20342	37245-37250	NN	denotes	E2f3a
T20343	37259-37262	CC	denotes	and
T20344	37263-37264	DT	denotes	a
T20345	37277-37288	NN	denotes	polypeptide
T20346	37265-37267	CD	denotes	40
T20347	37268-37270	NN	denotes	kD
T20348	37267-37268	HYPH	denotes	-
T20349	37271-37276	NN	denotes	E2f3b
T20350	37289-37290	-LRB-	denotes	(
T20351	37290-37296	NN	denotes	Figure
T20352	37297-37298	CD	denotes	6
T20353	37298-37299	-RRB-	denotes	)
T20354	37299-37300	.	denotes	.
T20355	37300-37487	sentence	denotes	To confirm that the upper species in our retinal lysates was E2f3a, we exploited novel mice that lack E2f3 exon 1a and thus express E2f3b exclusively (R. O. and G. L., unpublished data).
T20356	37301-37303	TO	denotes	To
T20357	37304-37311	VB	denotes	confirm
T20358	37372-37381	VBD	denotes	exploited
T20359	37312-37316	IN	denotes	that
T20360	37358-37361	VBD	denotes	was
T20361	37317-37320	DT	denotes	the
T20362	37327-37334	NNS	denotes	species
T20363	37321-37326	JJ	denotes	upper
T20364	37335-37337	IN	denotes	in
T20365	37338-37341	PRP$	denotes	our
T20366	37350-37357	NNS	denotes	lysates
T20367	37342-37349	JJ	denotes	retinal
T20368	37362-37367	NN	denotes	E2f3a
T20369	37367-37369	,	denotes	,
T20370	37369-37371	PRP	denotes	we
T20371	37382-37387	JJ	denotes	novel
T20372	37388-37392	NNS	denotes	mice
T20373	37393-37397	WDT	denotes	that
T20374	37398-37402	VBP	denotes	lack
T20375	37403-37407	NN	denotes	E2f3
T20376	37413-37415	NN	denotes	1a
T20377	37408-37412	NN	denotes	exon
T20378	37416-37419	CC	denotes	and
T20379	37420-37424	RB	denotes	thus
T20380	37425-37432	VBP	denotes	express
T20381	37433-37438	NN	denotes	E2f3b
T20382	37439-37450	RB	denotes	exclusively
T20383	37451-37452	-LRB-	denotes	(
T20384	37452-37454	NNP	denotes	R.
T20385	37455-37457	NNP	denotes	O.
T20386	37458-37461	CC	denotes	and
T20387	37462-37464	NNP	denotes	G.
T20388	37465-37467	NNP	denotes	L.
T20389	37467-37469	,	denotes	,
T20390	37469-37480	JJ	denotes	unpublished
T20391	37481-37485	NNS	denotes	data
T20392	37485-37486	-RRB-	denotes	)
T20393	37486-37487	.	denotes	.
T20394	37487-37570	sentence	denotes	The genotyping strategy is discussed in detail later and is outlined in Figure 7A.
T20395	37488-37491	DT	denotes	The
T20396	37503-37511	NN	denotes	strategy
T20397	37492-37502	NN	denotes	genotyping
T20398	37515-37524	VBN	denotes	discussed
T20399	37512-37514	VBZ	denotes	is
T20400	37525-37527	IN	denotes	in
T20401	37528-37534	NN	denotes	detail
T20402	37535-37540	RB	denotes	later
T20403	37541-37544	CC	denotes	and
T20404	37545-37547	VBZ	denotes	is
T20405	37548-37556	VBN	denotes	outlined
T20406	37557-37559	IN	denotes	in
T20407	37560-37566	NN	denotes	Figure
T20408	37567-37569	NN	denotes	7A
T20410	37570-37665	sentence	denotes	Western analysis confirmed that the upper band was absent in E2f3a−/− mice (Figures 6 and S8).
T20411	37571-37578	NNP	denotes	Western
T20412	37579-37587	NN	denotes	analysis
T20413	37588-37597	VBD	denotes	confirmed
T20414	37598-37602	IN	denotes	that
T20415	37618-37621	VBD	denotes	was
T20416	37603-37606	DT	denotes	the
T20417	37613-37617	NN	denotes	band
T20418	37607-37612	JJ	denotes	upper
T20419	37622-37628	JJ	denotes	absent
T20420	37629-37631	IN	denotes	in
T20421	37632-37637	NN	denotes	E2f3a
T20422	37641-37645	NNS	denotes	mice
T20423	37637-37638	SYM	denotes	−
T20424	37638-37639	HYPH	denotes	/
T20425	37639-37640	SYM	denotes	−
T20426	37646-37647	-LRB-	denotes	(
T20427	37661-37663	NN	denotes	S8
T20428	37647-37654	NNS	denotes	Figures
T20429	37655-37656	CD	denotes	6
T20430	37657-37660	CC	denotes	and
T20431	37663-37664	-RRB-	denotes	)
T20432	37664-37665	.	denotes	.
T20433	37665-37826	sentence	denotes	Consistent with the drop in E2f3-expressing cells during WT retinal maturation (Figure 5A), the total amount of E2f3a was less at P18 compared to P0 (Figure 6).
T20434	37666-37676	JJ	denotes	Consistent
T20435	37784-37787	VBD	denotes	was
T20436	37677-37681	IN	denotes	with
T20437	37682-37685	DT	denotes	the
T20438	37686-37690	NN	denotes	drop
T20439	37691-37693	IN	denotes	in
T20440	37694-37698	NN	denotes	E2f3
T20441	37699-37709	VBG	denotes	expressing
T20442	37698-37699	HYPH	denotes	-
T20443	37710-37715	NNS	denotes	cells
T20444	37716-37722	IN	denotes	during
T20445	37723-37725	NN	denotes	WT
T20446	37734-37744	NN	denotes	maturation
T20447	37726-37733	JJ	denotes	retinal
T20448	37745-37746	-LRB-	denotes	(
T20449	37753-37755	NN	denotes	5A
T20450	37746-37752	NN	denotes	Figure
T20451	37755-37756	-RRB-	denotes	)
T20452	37756-37758	,	denotes	,
T20453	37758-37761	DT	denotes	the
T20454	37768-37774	NN	denotes	amount
T20455	37762-37767	JJ	denotes	total
T20456	37775-37777	IN	denotes	of
T20457	37778-37783	NN	denotes	E2f3a
T20458	37788-37792	JJR	denotes	less
T20459	37793-37795	IN	denotes	at
T20460	37796-37799	NN	denotes	P18
T20461	37800-37808	VBN	denotes	compared
T20462	37809-37811	IN	denotes	to
T20463	37812-37814	NN	denotes	P0
T20464	37815-37816	-LRB-	denotes	(
T20465	37816-37822	NN	denotes	Figure
T20466	37823-37824	CD	denotes	6
T20467	37824-37825	-RRB-	denotes	)
T20468	37825-37826	.	denotes	.
T20469	37826-37884	sentence	denotes	E2f3b was present in similar amounts at both time points.
T20470	37827-37832	NN	denotes	E2f3b
T20471	37833-37836	VBD	denotes	was
T20472	37837-37844	JJ	denotes	present
T20473	37845-37847	IN	denotes	in
T20474	37848-37855	JJ	denotes	similar
T20475	37856-37863	NNS	denotes	amounts
T20476	37864-37866	IN	denotes	at
T20477	37867-37871	DT	denotes	both
T20478	37877-37883	NNS	denotes	points
T20479	37872-37876	NN	denotes	time
T20480	37883-37884	.	denotes	.
T20481	37884-38040	sentence	denotes	At P0 and P18, E2f3a was present in both nuclear and cytoplasmic fractions, but in marked contrast, E2f3b was exclusively nuclear at both times (Figure 6).
T20482	37885-37887	IN	denotes	At
T20483	37906-37909	VBD	denotes	was
T20484	37888-37890	NN	denotes	P0
T20485	37891-37894	CC	denotes	and
T20486	37895-37898	NN	denotes	P18
T20487	37898-37900	,	denotes	,
T20488	37900-37905	NN	denotes	E2f3a
T20489	37910-37917	JJ	denotes	present
T20490	37918-37920	IN	denotes	in
T20491	37921-37925	CC	denotes	both
T20492	37926-37933	JJ	denotes	nuclear
T20493	37950-37959	NNS	denotes	fractions
T20494	37934-37937	CC	denotes	and
T20495	37938-37949	JJ	denotes	cytoplasmic
T20496	37959-37961	,	denotes	,
T20497	37961-37964	CC	denotes	but
T20498	37965-37967	IN	denotes	in
T20499	37991-37994	VBD	denotes	was
T20500	37968-37974	JJ	denotes	marked
T20501	37975-37983	NN	denotes	contrast
T20502	37983-37985	,	denotes	,
T20503	37985-37990	NN	denotes	E2f3b
T20504	37995-38006	RB	denotes	exclusively
T20505	38007-38014	JJ	denotes	nuclear
T20506	38015-38017	IN	denotes	at
T20507	38018-38022	DT	denotes	both
T20508	38023-38028	NNS	denotes	times
T20509	38029-38030	-LRB-	denotes	(
T20510	38030-38036	NN	denotes	Figure
T20511	38037-38038	CD	denotes	6
T20512	38038-38039	-RRB-	denotes	)
T20513	38039-38040	.	denotes	.
T20514	38040-38241	sentence	denotes	Two closely migrating E2f3a bands were detected, more clearly evident at P18, of which the faster migrating species was dominant in nuclear and the slower species was dominant in cytoplasm (Figure 6).
T20515	38041-38044	CD	denotes	Two
T20516	38069-38074	NNS	denotes	bands
T20517	38045-38052	RB	denotes	closely
T20518	38053-38062	VBG	denotes	migrating
T20519	38063-38068	NN	denotes	E2f3a
T20520	38080-38088	VBN	denotes	detected
T20521	38075-38079	VBD	denotes	were
T20522	38088-38090	,	denotes	,
T20523	38090-38094	RBR	denotes	more
T20524	38095-38102	RB	denotes	clearly
T20525	38103-38110	JJ	denotes	evident
T20526	38111-38113	IN	denotes	at
T20527	38114-38117	NN	denotes	P18
T20528	38117-38119	,	denotes	,
T20529	38119-38121	IN	denotes	of
T20530	38157-38160	VBD	denotes	was
T20531	38122-38127	WDT	denotes	which
T20532	38128-38131	DT	denotes	the
T20533	38149-38156	NN	denotes	species
T20534	38132-38138	RBR	denotes	faster
T20535	38139-38148	VBG	denotes	migrating
T20536	38161-38169	JJ	denotes	dominant
T20537	38170-38172	IN	denotes	in
T20538	38173-38180	JJ	denotes	nuclear
T20539	38181-38184	CC	denotes	and
T20540	38185-38188	DT	denotes	the
T20541	38196-38203	NN	denotes	species
T20542	38189-38195	JJR	denotes	slower
T20543	38204-38207	VBD	denotes	was
T20544	38208-38216	JJ	denotes	dominant
T20545	38217-38219	IN	denotes	in
T20546	38220-38229	NN	denotes	cytoplasm
T20547	38230-38231	-LRB-	denotes	(
T20548	38231-38237	NN	denotes	Figure
T20549	38238-38239	CD	denotes	6
T20550	38239-38240	-RRB-	denotes	)
T20551	38240-38241	.	denotes	.
T20552	38241-38350	sentence	denotes	The identity of both as E2f3a species was confirmed by their absence in the P18 E2f3a KO retina (Figure S8).
T20553	38242-38245	DT	denotes	The
T20554	38246-38254	NN	denotes	identity
T20555	38284-38293	VBN	denotes	confirmed
T20556	38255-38257	IN	denotes	of
T20557	38258-38262	DT	denotes	both
T20558	38263-38265	IN	denotes	as
T20559	38266-38271	NN	denotes	E2f3a
T20560	38272-38279	NNS	denotes	species
T20561	38280-38283	VBD	denotes	was
T20562	38294-38296	IN	denotes	by
T20563	38297-38302	PRP$	denotes	their
T20564	38303-38310	NN	denotes	absence
T20565	38311-38313	IN	denotes	in
T20566	38314-38317	DT	denotes	the
T20567	38331-38337	NN	denotes	retina
T20568	38318-38321	NN	denotes	P18
T20569	38322-38327	NN	denotes	E2f3a
T20570	38328-38330	NN	denotes	KO
T20571	38338-38339	-LRB-	denotes	(
T20572	38346-38348	NN	denotes	S8
T20573	38339-38345	NN	denotes	Figure
T20574	38348-38349	-RRB-	denotes	)
T20575	38349-38350	.	denotes	.
T20576	38350-38618	sentence	denotes	Analysis of Pou4f2, a nuclear transcription factor expressed in ganglion cells, showed that nuclear proteins had not contaminated the cytoplasmic fraction, and analysis of Slc18a3, a cytoplasmic SAC marker, confirmed that the reverse had also not occurred (Figure 6).
T20577	38351-38359	NN	denotes	Analysis
T20578	38431-38437	VBD	denotes	showed
T20579	38360-38362	IN	denotes	of
T20580	38363-38369	NN	denotes	Pou4f2
T20581	38369-38371	,	denotes	,
T20582	38371-38372	DT	denotes	a
T20583	38395-38401	NN	denotes	factor
T20584	38373-38380	JJ	denotes	nuclear
T20585	38381-38394	NN	denotes	transcription
T20586	38402-38411	VBN	denotes	expressed
T20587	38412-38414	IN	denotes	in
T20588	38415-38423	NN	denotes	ganglion
T20589	38424-38429	NNS	denotes	cells
T20590	38429-38431	,	denotes	,
T20591	38438-38442	IN	denotes	that
T20592	38468-38480	VBN	denotes	contaminated
T20593	38443-38450	JJ	denotes	nuclear
T20594	38451-38459	NN	denotes	proteins
T20595	38460-38463	VBD	denotes	had
T20596	38464-38467	RB	denotes	not
T20597	38481-38484	DT	denotes	the
T20598	38497-38505	NN	denotes	fraction
T20599	38485-38496	JJ	denotes	cytoplasmic
T20600	38505-38507	,	denotes	,
T20601	38507-38510	CC	denotes	and
T20602	38511-38519	NN	denotes	analysis
T20603	38558-38567	VBD	denotes	confirmed
T20604	38520-38522	IN	denotes	of
T20605	38523-38530	NN	denotes	Slc18a3
T20606	38530-38532	,	denotes	,
T20607	38532-38533	DT	denotes	a
T20608	38550-38556	NN	denotes	marker
T20609	38534-38545	JJ	denotes	cytoplasmic
T20610	38546-38549	NN	denotes	SAC
T20611	38556-38558	,	denotes	,
T20612	38568-38572	IN	denotes	that
T20613	38598-38606	VBN	denotes	occurred
T20614	38573-38576	DT	denotes	the
T20615	38577-38584	NN	denotes	reverse
T20616	38585-38588	VBD	denotes	had
T20617	38589-38593	RB	denotes	also
T20618	38594-38597	RB	denotes	not
T20619	38607-38608	-LRB-	denotes	(
T20716	40966-40967	-RRB-	denotes	)
T20717	40967-40968	.	denotes	.
T20718	40968-41153	sentence	denotes	A very faint cytoplasmic Rb signal was evident at P18, which is consistent with Rb staining of SAC processes (Figure 5B), and with the very small proportion of SACs in the retina [38].
T20719	40969-40970	DT	denotes	A
T20720	40997-41003	NN	denotes	signal
T20721	40971-40975	RB	denotes	very
T20722	40976-40981	JJ	denotes	faint
T20723	40982-40993	JJ	denotes	cytoplasmic
T20724	40994-40996	NN	denotes	Rb
T20725	41004-41007	VBD	denotes	was
T20726	41008-41015	JJ	denotes	evident
T20727	41016-41018	IN	denotes	at
T20728	41019-41022	NN	denotes	P18
T20729	41022-41024	,	denotes	,
T20730	41024-41029	WDT	denotes	which
T20731	41030-41032	VBZ	denotes	is
T20732	41033-41043	JJ	denotes	consistent
T20733	41044-41048	IN	denotes	with
T20734	41049-41051	NN	denotes	Rb
T20735	41052-41060	NN	denotes	staining
T20736	41061-41063	IN	denotes	of
T20737	41064-41067	NN	denotes	SAC
T20738	41068-41077	NNS	denotes	processes
T20739	41078-41079	-LRB-	denotes	(
T20740	41086-41088	NN	denotes	5B
T20741	41079-41085	NN	denotes	Figure
T20742	41088-41089	-RRB-	denotes	)
T20743	41089-41091	,	denotes	,
T20744	41091-41094	CC	denotes	and
T20745	41095-41099	IN	denotes	with
T20746	41100-41103	DT	denotes	the
T20747	41115-41125	NN	denotes	proportion
T20748	41104-41108	RB	denotes	very
T20749	41109-41114	JJ	denotes	small
T20750	41126-41128	IN	denotes	of
T20751	41129-41133	NNS	denotes	SACs
T20752	41134-41136	IN	denotes	in
T20753	41137-41140	DT	denotes	the
T20754	41141-41147	NN	denotes	retina
T20755	41148-41149	-LRB-	denotes	[
T20756	41149-41151	CD	denotes	38
T20757	41151-41152	-RRB-	denotes	]
T20758	41152-41153	.	denotes	.
T20759	41153-41301	sentence	denotes	E2f1 was also detected in both nuclear and cytoplasmic fractions, although unlike E2f3a it was predominantly nuclear both at P0 and P18 (Figure 6).
T20760	41154-41158	NN	denotes	E2f1
T20761	41168-41176	VBN	denotes	detected
T20762	41159-41162	VBD	denotes	was
T20763	41163-41167	RB	denotes	also
T20764	41177-41179	IN	denotes	in
T20765	41180-41184	CC	denotes	both
T20766	41185-41192	JJ	denotes	nuclear
T20767	41209-41218	NNS	denotes	fractions
T20768	41193-41196	CC	denotes	and
T20769	41197-41208	JJ	denotes	cytoplasmic
T20770	41218-41220	,	denotes	,
T20771	41220-41228	IN	denotes	although
T20772	41245-41248	VBD	denotes	was
T20773	41229-41235	IN	denotes	unlike
T20774	41236-41241	NN	denotes	E2f3a
T20775	41242-41244	PRP	denotes	it
T20776	41249-41262	RB	denotes	predominantly
T20777	41263-41270	JJ	denotes	nuclear
T20778	41271-41275	CC	denotes	both
T20779	41276-41278	IN	denotes	at
T20780	41279-41281	NN	denotes	P0
T20781	41282-41285	CC	denotes	and
T20782	41286-41289	NN	denotes	P18
T20783	41290-41291	-LRB-	denotes	(
T20784	41291-41297	NN	denotes	Figure
T20785	41298-41299	CD	denotes	6
T20786	41299-41300	-RRB-	denotes	)
T20787	41300-41301	.	denotes	.
T20788	41301-41526	sentence	denotes	The E2f dimerization partner, Tfdp1, which lacks a nuclear localization signal [54], was primarily cytoplasmic at both P0 and P18, and the Cdk inhibitors Cdkn1a and Cdkn1b showed a similar pattern of distribution (Figure 6).
T20789	41302-41305	DT	denotes	The
T20790	41323-41330	NN	denotes	partner
T20791	41306-41309	NN	denotes	E2f
T20792	41310-41322	NN	denotes	dimerization
T20793	41387-41390	VBD	denotes	was
T20794	41330-41332	,	denotes	,
T20795	41332-41337	NN	denotes	Tfdp1
T20796	41337-41339	,	denotes	,
T20797	41339-41344	WDT	denotes	which
T20798	41345-41350	VBZ	denotes	lacks
T20799	41351-41352	DT	denotes	a
T20800	41374-41380	NN	denotes	signal
T20801	41353-41360	JJ	denotes	nuclear
T20802	41361-41373	NN	denotes	localization
T20803	41381-41382	-LRB-	denotes	[
T20804	41382-41384	CD	denotes	54
T20805	41384-41385	-RRB-	denotes	]
T20806	41385-41387	,	denotes	,
T20807	41391-41400	RB	denotes	primarily
T20808	41401-41412	JJ	denotes	cytoplasmic
T20809	41413-41415	IN	denotes	at
T20810	41416-41420	CC	denotes	both
T20811	41421-41423	NN	denotes	P0
T20812	41424-41427	CC	denotes	and
T20813	41428-41431	NN	denotes	P18
T20814	41431-41433	,	denotes	,
T20815	41433-41436	CC	denotes	and
T20816	41437-41440	DT	denotes	the
T20817	41445-41455	NNS	denotes	inhibitors
T20818	41441-41444	NN	denotes	Cdk
T20819	41474-41480	VBD	denotes	showed
T20820	41456-41462	NN	denotes	Cdkn1a
T20821	41463-41466	CC	denotes	and
T20822	41467-41473	NN	denotes	Cdkn1b
T20823	41481-41482	DT	denotes	a
T20824	41491-41498	NN	denotes	pattern
T20825	41483-41490	JJ	denotes	similar
T20826	41499-41501	IN	denotes	of
T20827	41502-41514	NN	denotes	distribution
T20828	41515-41516	-LRB-	denotes	(
T20829	41516-41522	NN	denotes	Figure
T20830	41523-41524	CD	denotes	6
T20831	41524-41525	-RRB-	denotes	)
T20832	41525-41526	.	denotes	.
T20833	41526-41678	sentence	denotes	Thus, among the cell cycle regulators we examined, most showed bivalent distribution, and E2f3b was unusual in its solely nuclear compartmentalization.
T20834	41527-41531	RB	denotes	Thus
T20835	41583-41589	VBD	denotes	showed
T20836	41531-41533	,	denotes	,
T20837	41533-41538	IN	denotes	among
T20838	41539-41542	DT	denotes	the
T20839	41554-41564	NNS	denotes	regulators
T20840	41543-41547	NN	denotes	cell
T20841	41548-41553	NN	denotes	cycle
T20842	41565-41567	PRP	denotes	we
T20843	41568-41576	VBD	denotes	examined
T20844	41576-41578	,	denotes	,
T20845	41578-41582	JJS	denotes	most
T20846	41590-41598	JJ	denotes	bivalent
T20847	41599-41611	NN	denotes	distribution
T20848	41611-41613	,	denotes	,
T20849	41613-41616	CC	denotes	and
T20850	41617-41622	NN	denotes	E2f3b
T20851	41623-41626	VBD	denotes	was
T20852	41627-41634	JJ	denotes	unusual
T20853	41635-41637	IN	denotes	in
T20854	41638-41641	PRP$	denotes	its
T20855	41657-41677	NN	denotes	compartmentalization
T20856	41642-41648	RB	denotes	solely
T20857	41649-41656	JJ	denotes	nuclear
T20858	41677-41678	.	denotes	.
T21518	41845-41846	-RRB-	denotes	)
T21519	41846-41847	.	denotes	.
T21520	41847-41950	sentence	denotes	The genotyping strategy outlined in Figure 7A was used to distinguish the E2f3a, WT, and null alleles.
T21488	41680-41682	NN	denotes	Rb
T21489	41683-41692	VBZ	denotes	Regulates
T21490	41693-41696	NN	denotes	SAC
T21491	41697-41712	NN	denotes	Differentiation
T21492	41713-41720	IN	denotes	through
T21493	41721-41726	NN	denotes	E2f3a
T21494	41726-41847	sentence	denotes	To test which E2f3 isoform is responsible for aberrant Rb KO SAC differentiation we exploited E2f3a−/− mice (Figure 7A).
T21495	41727-41729	TO	denotes	To
T21496	41730-41734	VB	denotes	test
T21497	41811-41820	VBD	denotes	exploited
T21498	41735-41740	WDT	denotes	which
T21499	41746-41753	NN	denotes	isoform
T21500	41741-41745	NN	denotes	E2f3
T21501	41754-41756	VBZ	denotes	is
T21502	41757-41768	JJ	denotes	responsible
T21503	41769-41772	IN	denotes	for
T21504	41773-41781	JJ	denotes	aberrant
T21505	41792-41807	NN	denotes	differentiation
T21506	41782-41784	NN	denotes	Rb
T21507	41785-41787	NN	denotes	KO
T21508	41788-41791	NN	denotes	SAC
T21509	41808-41810	PRP	denotes	we
T21510	41821-41826	NN	denotes	E2f3a
T21511	41830-41834	NNS	denotes	mice
T21512	41826-41827	SYM	denotes	−
T21513	41827-41828	HYPH	denotes	/
T21514	41828-41829	SYM	denotes	−
T21515	41835-41836	-LRB-	denotes	(
T21516	41843-41845	NN	denotes	7A
T21517	41836-41842	NN	denotes	Figure
T21521	41848-41851	DT	denotes	The
T21522	41863-41871	NN	denotes	strategy
T21523	41852-41862	NN	denotes	genotyping
T21524	41898-41902	VBN	denotes	used
T21525	41872-41880	VBN	denotes	outlined
T21526	41881-41883	IN	denotes	in
T21527	41884-41890	NN	denotes	Figure
T21528	41891-41893	NN	denotes	7A
T21529	41894-41897	VBD	denotes	was
T21530	41903-41905	TO	denotes	to
T21531	41906-41917	VB	denotes	distinguish
T21532	41918-41921	DT	denotes	the
T21533	41942-41949	NNS	denotes	alleles
T21534	41922-41927	NN	denotes	E2f3a
T21535	41927-41929	,	denotes	,
T21536	41929-41931	NN	denotes	WT
T21537	41931-41933	,	denotes	,
T21538	41933-41936	CC	denotes	and
T21539	41937-41941	JJ	denotes	null
T21540	41949-41950	.	denotes	.
T21541	41950-42147	sentence	denotes	Reverse transcriptase PCR (RT-PCR) confirmed the presence of both E2f3a and E2f3b RNA species in the developing WT retina, and the specific absence of E2f3a RNA in the E2f3a−/− retina (Figure 7B).
T21542	41951-41958	JJ	denotes	Reverse
T21543	41973-41976	NN	denotes	PCR
T21544	41959-41972	NN	denotes	transcriptase
T21545	41986-41995	VBD	denotes	confirmed
T21546	41977-41978	-LRB-	denotes	(
T21547	41978-41980	NN	denotes	RT
T21548	41981-41984	NN	denotes	PCR
T21549	41980-41981	HYPH	denotes	-
T21550	41984-41985	-RRB-	denotes	)
T21551	41996-41999	DT	denotes	the
T21552	42000-42008	NN	denotes	presence
T21553	42009-42011	IN	denotes	of
T21554	42012-42016	CC	denotes	both
T21555	42017-42022	NN	denotes	E2f3a
T21556	42037-42044	NNS	denotes	species
T21557	42023-42026	CC	denotes	and
T21558	42027-42032	NN	denotes	E2f3b
T21559	42033-42036	NN	denotes	RNA
T21560	42045-42047	IN	denotes	in
T21561	42048-42051	DT	denotes	the
T21562	42066-42072	NN	denotes	retina
T21563	42052-42062	VBG	denotes	developing
T21564	42063-42065	NN	denotes	WT
T21565	42072-42074	,	denotes	,
T21566	42074-42077	CC	denotes	and
T21567	42078-42081	DT	denotes	the
T21568	42091-42098	NN	denotes	absence
T21569	42082-42090	JJ	denotes	specific
T21570	42099-42101	IN	denotes	of
T21571	42102-42107	NN	denotes	E2f3a
T21572	42108-42111	NN	denotes	RNA
T21573	42112-42114	IN	denotes	in
T21574	42115-42118	DT	denotes	the
T21575	42128-42134	NN	denotes	retina
T21576	42119-42124	NN	denotes	E2f3a
T21577	42124-42125	SYM	denotes	−
T21578	42125-42126	HYPH	denotes	/
T21579	42126-42127	SYM	denotes	−
T21580	42135-42136	-LRB-	denotes	(
T21581	42143-42145	NN	denotes	7B
T21582	42136-42142	NN	denotes	Figure
T21583	42145-42146	-RRB-	denotes	)
T21584	42146-42147	.	denotes	.
T21585	42147-42219	sentence	denotes	E2f3a protein was absent in E2f3a−/− retinal lysate (Figures 6 and S8).
T21586	42148-42153	NN	denotes	E2f3a
T21587	42154-42161	NN	denotes	protein
T21588	42162-42165	VBD	denotes	was
T21589	42166-42172	JJ	denotes	absent
T21590	42173-42175	IN	denotes	in
T21591	42176-42181	NN	denotes	E2f3a
T21592	42193-42199	NN	denotes	lysate
T21593	42181-42182	SYM	denotes	−
T21594	42182-42183	HYPH	denotes	/
T21595	42183-42184	SYM	denotes	−
T21596	42185-42192	JJ	denotes	retinal
T21597	42200-42201	-LRB-	denotes	(
T21598	42215-42217	NN	denotes	S8
T21599	42201-42208	NNS	denotes	Figures
T21600	42209-42210	CD	denotes	6
T21601	42211-42214	CC	denotes	and
T21602	42217-42218	-RRB-	denotes	)
T21603	42218-42219	.	denotes	.
T21604	42219-42440	sentence	denotes	Importantly, the levels of E2f3b message were similar in the Rb KO and Rb/E2f3a DKO retina, ruling out the possibility that any effects of E2f3a deletion we might observe were due to down-regulation of E2f3b (Figure 7C).
T21605	42220-42231	RB	denotes	Importantly
T21606	42261-42265	VBD	denotes	were
T21607	42231-42233	,	denotes	,
T21608	42233-42236	DT	denotes	the
T21609	42237-42243	NNS	denotes	levels
T21610	42244-42246	IN	denotes	of
T21611	42247-42252	NN	denotes	E2f3b
T21612	42253-42260	NN	denotes	message
T21613	42266-42273	JJ	denotes	similar
T21614	42274-42276	IN	denotes	in
T21615	42277-42280	DT	denotes	the
T21616	42304-42310	NN	denotes	retina
T21617	42281-42283	NN	denotes	Rb
T21618	42284-42286	NN	denotes	KO
T21619	42287-42290	CC	denotes	and
T21620	42291-42293	NN	denotes	Rb
T21621	42294-42299	NN	denotes	E2f3a
T21622	42293-42294	HYPH	denotes	/
T21623	42300-42303	NN	denotes	DKO
T21624	42310-42312	,	denotes	,
T21625	42312-42318	VBG	denotes	ruling
T21626	42319-42322	RP	denotes	out
T21627	42323-42326	DT	denotes	the
T21628	42327-42338	NN	denotes	possibility
T21629	42339-42343	IN	denotes	that
T21630	42391-42395	VBD	denotes	were
T21631	42344-42347	DT	denotes	any
T21632	42348-42355	NNS	denotes	effects
T21633	42356-42358	IN	denotes	of
T21634	42359-42364	NN	denotes	E2f3a
T21635	42365-42373	NN	denotes	deletion
T21636	42374-42376	PRP	denotes	we
T21637	42383-42390	VB	denotes	observe
T21638	42377-42382	MD	denotes	might
T21639	42396-42399	IN	denotes	due
T21640	42400-42402	IN	denotes	to
T21641	42403-42407	JJ	denotes	down
T21642	42408-42418	NN	denotes	regulation
T21643	42407-42408	HYPH	denotes	-
T21644	42419-42421	IN	denotes	of
T21645	42422-42427	NN	denotes	E2f3b
T21646	42428-42429	-LRB-	denotes	(
T21647	42436-42438	NN	denotes	7C
T21648	42429-42435	NN	denotes	Figure
T21649	42438-42439	-RRB-	denotes	)
T21650	42439-42440	.	denotes	.
T21651	42440-42595	sentence	denotes	Also, the levels of other E2fs were the same in the Rb KO, Rb/E2f3 DKO, and Rb/E2f3a DKO retina, ruling out any cross-regulatory effects (Figure 7C) [55].
T21652	42441-42445	RB	denotes	Also
T21653	42472-42476	VBD	denotes	were
T21654	42445-42447	,	denotes	,
T21655	42447-42450	DT	denotes	the
T21656	42451-42457	NNS	denotes	levels
T21657	42458-42460	IN	denotes	of
T21658	42461-42466	JJ	denotes	other
T21659	42467-42471	NNS	denotes	E2fs
T21660	42477-42480	DT	denotes	the
T21661	42481-42485	JJ	denotes	same
T21662	42486-42488	IN	denotes	in
T21663	42489-42492	DT	denotes	the
T21664	42530-42536	NN	denotes	retina
T21665	42493-42495	NN	denotes	Rb
T21666	42496-42498	NN	denotes	KO
T21667	42498-42500	,	denotes	,
T21668	42500-42502	NN	denotes	Rb
T21669	42503-42507	NN	denotes	E2f3
T21670	42502-42503	HYPH	denotes	/
T21671	42508-42511	NN	denotes	DKO
T21672	42511-42513	,	denotes	,
T21673	42513-42516	CC	denotes	and
T21674	42517-42519	NN	denotes	Rb
T21675	42520-42525	NN	denotes	E2f3a
T21676	42519-42520	HYPH	denotes	/
T21677	42526-42529	NN	denotes	DKO
T21678	42536-42538	,	denotes	,
T21679	42538-42544	VBG	denotes	ruling
T21680	42545-42548	RP	denotes	out
T21681	42549-42552	DT	denotes	any
T21682	42570-42577	NNS	denotes	effects
T21683	42553-42558	RB	denotes	cross
T21684	42559-42569	JJ	denotes	regulatory
T21685	42558-42559	HYPH	denotes	-
T21686	42578-42579	-LRB-	denotes	(
T21687	42586-42588	NN	denotes	7C
T21688	42579-42585	NN	denotes	Figure
T21689	42588-42589	-RRB-	denotes	)
T21690	42590-42591	-LRB-	denotes	[
T21691	42591-42593	CD	denotes	55
T21692	42593-42594	-RRB-	denotes	]
T21693	42594-42595	.	denotes	.
T21694	42595-42880	sentence	denotes	E2f3a can trigger cell cycle induction, but because SAC defects are not linked to cell cycle perturbation (Figures 3A and 4), and in view of the predominant association between E2f3b and Rb in quiescent cells [16,19], we suspected that E2f3b may perturb differentiation in Rb KO SACs.
T21695	42596-42601	NN	denotes	E2f3a
T21696	42606-42613	VB	denotes	trigger
T21697	42602-42605	MD	denotes	can
T21698	42614-42618	NN	denotes	cell
T21699	42619-42624	NN	denotes	cycle
T21700	42625-42634	NN	denotes	induction
T21701	42634-42636	,	denotes	,
T21702	42636-42639	CC	denotes	but
T21703	42640-42647	IN	denotes	because
T21704	42668-42674	VBN	denotes	linked
T21705	42648-42651	NN	denotes	SAC
T21706	42652-42659	NNS	denotes	defects
T21707	42660-42663	VBP	denotes	are
T21708	42664-42667	RB	denotes	not
T21709	42817-42826	VBD	denotes	suspected
T21710	42675-42677	IN	denotes	to
T21711	42678-42682	NN	denotes	cell
T21712	42683-42688	NN	denotes	cycle
T21713	42689-42701	NN	denotes	perturbation
T21714	42702-42703	-LRB-	denotes	(
T21715	42711-42713	NN	denotes	3A
T21716	42703-42710	NNS	denotes	Figures
T21717	42714-42717	CC	denotes	and
T21718	42718-42719	CD	denotes	4
T21719	42719-42720	-RRB-	denotes	)
T21720	42720-42722	,	denotes	,
T21721	42722-42725	CC	denotes	and
T21722	42726-42728	IN	denotes	in
T21723	42729-42733	NN	denotes	view
T21724	42734-42736	IN	denotes	of
T21725	42737-42740	DT	denotes	the
T21726	42753-42764	NN	denotes	association
T21727	42741-42752	JJ	denotes	predominant
T21728	42765-42772	IN	denotes	between
T21729	42773-42778	NN	denotes	E2f3b
T21730	42779-42782	CC	denotes	and
T21731	42783-42785	NN	denotes	Rb
T21732	42786-42788	IN	denotes	in
T21733	42789-42798	JJ	denotes	quiescent
T21734	42799-42804	NNS	denotes	cells
T21735	42805-42806	-LRB-	denotes	[
T21736	42809-42811	CD	denotes	19
T21737	42806-42808	CD	denotes	16
T21738	42808-42809	,	denotes	,
T21739	42811-42812	-RRB-	denotes	]
T21740	42812-42814	,	denotes	,
T21741	42814-42816	PRP	denotes	we
T21742	42827-42831	IN	denotes	that
T21743	42842-42849	VB	denotes	perturb
T21744	42832-42837	NN	denotes	E2f3b
T21745	42838-42841	MD	denotes	may
T21746	42850-42865	NN	denotes	differentiation
T21747	42866-42868	IN	denotes	in
T21748	42869-42871	NN	denotes	Rb
T21749	42872-42874	NN	denotes	KO
T21750	42875-42879	NNS	denotes	SACs
T21751	42879-42880	.	denotes	.
T21752	42880-42963	sentence	denotes	Unexpectedly, however, E2f3a deletion suppressed the Rb KO SAC defect (Figure 7D).
T21753	42881-42893	RB	denotes	Unexpectedly
T21754	42919-42929	VBD	denotes	suppressed
T21755	42893-42895	,	denotes	,
T21756	42895-42902	RB	denotes	however
T21757	42902-42904	,	denotes	,
T21758	42904-42909	NN	denotes	E2f3a
T21759	42910-42918	NN	denotes	deletion
T21760	42930-42933	DT	denotes	the
T21761	42944-42950	NN	denotes	defect
T21762	42934-42936	NN	denotes	Rb
T21763	42937-42939	NN	denotes	KO
T21764	42940-42943	NN	denotes	SAC
T21765	42951-42952	-LRB-	denotes	(
T21766	42959-42961	NN	denotes	7D
T21767	42952-42958	NN	denotes	Figure
T21768	42961-42962	-RRB-	denotes	)
T21769	42962-42963	.	denotes	.
T21770	42963-43093	sentence	denotes	Thus, separate from its role in cell cycle control, Rb regulation of E2f3a is critical to ensure proper neuronal differentiation.
T21771	42964-42968	RB	denotes	Thus
T21772	43039-43041	VBZ	denotes	is
T21773	42968-42970	,	denotes	,
T21774	42970-42978	JJ	denotes	separate
T21775	42979-42983	IN	denotes	from
T21776	42984-42987	PRP$	denotes	its
T21777	42988-42992	NN	denotes	role
T21778	42993-42995	IN	denotes	in
T21779	42996-43000	NN	denotes	cell
T21780	43001-43006	NN	denotes	cycle
T21781	43007-43014	NN	denotes	control
T21782	43014-43016	,	denotes	,
T21783	43016-43018	NN	denotes	Rb
T21784	43019-43029	NN	denotes	regulation
T21785	43030-43032	IN	denotes	of
T21786	43033-43038	NN	denotes	E2f3a
T21787	43042-43050	JJ	denotes	critical
T21788	43051-43053	TO	denotes	to
T21789	43054-43060	VB	denotes	ensure
T21790	43061-43067	JJ	denotes	proper
T21791	43077-43092	NN	denotes	differentiation
T21792	43068-43076	JJ	denotes	neuronal
T21793	43092-43093	.	denotes	.
T23003	43107-43109	NN	denotes	Rb
T23004	43110-43118	VBZ	denotes	Controls
T23005	43119-43126	JJ	denotes	Retinal
T23006	43127-43131	NN	denotes	Cell
T23007	43132-43140	NN	denotes	Division
T23008	43141-43144	CC	denotes	and
T23009	43145-43150	NN	denotes	Death
T23010	43151-43158	IN	denotes	through
T23011	43159-43163	NN	denotes	E2f1
T23012	43163-43292	sentence	denotes	Work in the early 1990s showed that Rb loss triggers defects in neuronal cell cycle exit, survival, and differentiation [26–28].
T23013	43164-43168	NN	denotes	Work
T23014	43188-43194	VBD	denotes	showed
T23015	43169-43171	IN	denotes	in
T23016	43172-43175	DT	denotes	the
T23017	43182-43187	NNS	denotes	1990s
T23018	43176-43181	JJ	denotes	early
T23019	43195-43199	IN	denotes	that
T23020	43208-43216	VBZ	denotes	triggers
T23021	43200-43202	NN	denotes	Rb
T23022	43203-43207	NN	denotes	loss
T23023	43217-43224	NNS	denotes	defects
T23024	43225-43227	IN	denotes	in
T23025	43228-43236	JJ	denotes	neuronal
T23026	43248-43252	NN	denotes	exit
T23027	43237-43241	NN	denotes	cell
T23028	43242-43247	NN	denotes	cycle
T23029	43252-43254	,	denotes	,
T23030	43254-43262	NN	denotes	survival
T23031	43262-43264	,	denotes	,
T23032	43264-43267	CC	denotes	and
T23033	43268-43283	NN	denotes	differentiation
T23034	43284-43285	-LRB-	denotes	[
T23035	43285-43287	CD	denotes	26
T23036	43287-43288	SYM	denotes	–
T23037	43288-43290	CD	denotes	28
T23038	43290-43291	-RRB-	denotes	]
T23039	43291-43292	.	denotes	.
T23040	43292-43394	sentence	denotes	Much of the death is an indirect consequence of probable hypoxia linked to placental defects [12–14].
T23041	43293-43297	JJ	denotes	Much
T23042	43311-43313	VBZ	denotes	is
T23043	43298-43300	IN	denotes	of
T23044	43301-43304	DT	denotes	the
T23045	43305-43310	NN	denotes	death
T23046	43314-43316	DT	denotes	an
T23047	43326-43337	NN	denotes	consequence
T23048	43317-43325	JJ	denotes	indirect
T23049	43338-43340	IN	denotes	of
T23050	43341-43349	JJ	denotes	probable
T23051	43350-43357	NN	denotes	hypoxia
T23052	43358-43364	VBN	denotes	linked
T23053	43365-43367	IN	denotes	to
T23054	43368-43377	JJ	denotes	placental
T23055	43378-43385	NNS	denotes	defects
T23056	43386-43387	-LRB-	denotes	[
T23057	43387-43389	CD	denotes	12
T23058	43389-43390	SYM	denotes	–
T23059	43390-43392	CD	denotes	14
T23060	43392-43393	-RRB-	denotes	]
T23061	43393-43394	.	denotes	.
T23062	43394-43608	sentence	denotes	However, targeted KO and chimeric studies reveal that Rb autonomously promotes cell cycle exit in newborn neurons, and is required for survival of a subset of neurons, particularly in the retina [2,3,13,14,56–59].
T23063	43395-43402	RB	denotes	However
T23064	43437-43443	VBP	denotes	reveal
T23065	43402-43404	,	denotes	,
T23066	43404-43412	VBN	denotes	targeted
T23067	43413-43415	NN	denotes	KO
T23068	43429-43436	NNS	denotes	studies
T23069	43416-43419	CC	denotes	and
T23070	43420-43428	JJ	denotes	chimeric
T23071	43444-43448	IN	denotes	that
T23072	43465-43473	VBZ	denotes	promotes
T23073	43449-43451	NN	denotes	Rb
T23074	43452-43464	RB	denotes	autonomously
T23075	43474-43478	NN	denotes	cell
T23076	43479-43484	NN	denotes	cycle
T23077	43485-43489	NN	denotes	exit
T23078	43490-43492	IN	denotes	in
T23079	43493-43500	JJ	denotes	newborn
T23080	43501-43508	NNS	denotes	neurons
T23081	43508-43510	,	denotes	,
T23082	43510-43513	CC	denotes	and
T23083	43514-43516	VBZ	denotes	is
T23084	43517-43525	VBN	denotes	required
T23085	43526-43529	IN	denotes	for
T23086	43530-43538	NN	denotes	survival
T23087	43539-43541	IN	denotes	of
T23088	43542-43543	DT	denotes	a
T23089	43544-43550	NN	denotes	subset
T23090	43551-43553	IN	denotes	of
T23091	43554-43561	NNS	denotes	neurons
T23092	43561-43563	,	denotes	,
T23093	43563-43575	RB	denotes	particularly
T23094	43576-43578	IN	denotes	in
T23095	43579-43582	DT	denotes	the
T23096	43583-43589	NN	denotes	retina
T23097	43590-43591	-LRB-	denotes	[
T23098	43591-43592	CD	denotes	2
T23099	43592-43593	,	denotes	,
T23100	43593-43594	CD	denotes	3
T23101	43594-43595	,	denotes	,
T23102	43595-43597	CD	denotes	13
T23103	43597-43598	,	denotes	,
T23104	43598-43600	CD	denotes	14
T23105	43600-43601	,	denotes	,
T23106	43601-43603	CD	denotes	56
T23107	43603-43604	SYM	denotes	–
T23108	43604-43606	CD	denotes	59
T23109	43606-43607	-RRB-	denotes	]
T23110	43607-43608	.	denotes	.
T23111	43608-43734	sentence	denotes	However, whether Rb also regulates differentiation is obscured by potentially indirect effects of ectopic division and death.
T23112	43609-43616	RB	denotes	However
T23113	43663-43671	VBN	denotes	obscured
T23114	43616-43618	,	denotes	,
T23115	43618-43625	IN	denotes	whether
T23116	43634-43643	VBZ	denotes	regulates
T23117	43626-43628	NN	denotes	Rb
T23118	43629-43633	RB	denotes	also
T23119	43644-43659	NN	denotes	differentiation
T23120	43660-43662	VBZ	denotes	is
T23121	43672-43674	IN	denotes	by
T23122	43675-43686	RB	denotes	potentially
T23123	43687-43695	JJ	denotes	indirect
T23124	43696-43703	NNS	denotes	effects
T23125	43704-43706	IN	denotes	of
T23126	43707-43714	JJ	denotes	ectopic
T23127	43715-43723	NN	denotes	division
T23128	43724-43727	CC	denotes	and
T23129	43728-43733	NN	denotes	death
T23130	43733-43734	.	denotes	.
T23131	43734-43830	sentence	denotes	Moreover, a mechanism though which Rb may regulate neuronal maturation has not been elucidated.
T23132	43735-43743	RB	denotes	Moreover
T23133	43819-43829	VBN	denotes	elucidated
T23134	43743-43745	,	denotes	,
T23135	43745-43746	DT	denotes	a
T23136	43747-43756	NN	denotes	mechanism
T23137	43757-43763	IN	denotes	though
T23138	43777-43785	VB	denotes	regulate
T23139	43764-43769	WDT	denotes	which
T23140	43770-43772	NN	denotes	Rb
T23141	43773-43776	MD	denotes	may
T23142	43786-43794	JJ	denotes	neuronal
T23143	43795-43805	NN	denotes	maturation
T23144	43806-43809	VBZ	denotes	has
T23145	43810-43813	RB	denotes	not
T23146	43814-43818	VBN	denotes	been
T23147	43829-43830	.	denotes	.
T23148	43830-43919	sentence	denotes	Here, deleting E2f1 specifically rescued ectopic division and death in the Rb KO retina.
T23149	43831-43835	RB	denotes	Here
T23150	43864-43871	VBD	denotes	rescued
T23151	43835-43837	,	denotes	,
T23152	43837-43845	VBG	denotes	deleting
T23153	43846-43850	NN	denotes	E2f1
T23154	43851-43863	RB	denotes	specifically
T23155	43872-43879	JJ	denotes	ectopic
T23156	43880-43888	NN	denotes	division
T23157	43889-43892	CC	denotes	and
T23158	43893-43898	NN	denotes	death
T23159	43899-43901	IN	denotes	in
T23160	43902-43905	DT	denotes	the
T23161	43912-43918	NN	denotes	retina
T23162	43906-43908	NN	denotes	Rb
T23163	43909-43911	NN	denotes	KO
T23164	43918-43919	.	denotes	.
T23165	43919-44133	sentence	denotes	Importantly, major Rb/E2f1 DKO neurons differentiated normally, and ERGs revealed the rescue of rod- and cone-mediated function, implicating a regular signal flow from photoreceptors to bipolar and amacrine cells.
T23166	43920-43931	RB	denotes	Importantly
T23167	43959-43973	VBD	denotes	differentiated
T23168	43931-43933	,	denotes	,
T23169	43933-43938	JJ	denotes	major
T23170	43951-43958	NNS	denotes	neurons
T23171	43939-43941	NN	denotes	Rb
T23172	43942-43946	NN	denotes	E2f1
T23173	43941-43942	HYPH	denotes	/
T23174	43947-43950	NN	denotes	DKO
T23175	43974-43982	RB	denotes	normally
T23176	43982-43984	,	denotes	,
T23177	43984-43987	CC	denotes	and
T23178	43988-43992	NNS	denotes	ERGs
T23179	43993-44001	VBD	denotes	revealed
T23180	44002-44005	DT	denotes	the
T23181	44006-44012	NN	denotes	rescue
T23182	44013-44015	IN	denotes	of
T23183	44016-44019	NN	denotes	rod
T23184	44030-44038	VBN	denotes	mediated
T23185	44019-44020	HYPH	denotes	-
T23186	44021-44024	CC	denotes	and
T23187	44025-44029	NN	denotes	cone
T23188	44029-44030	HYPH	denotes	-
T23189	44039-44047	NN	denotes	function
T23190	44047-44049	,	denotes	,
T23191	44049-44060	VBG	denotes	implicating
T23192	44061-44062	DT	denotes	a
T23193	44078-44082	NN	denotes	flow
T23194	44063-44070	JJ	denotes	regular
T23195	44071-44077	NN	denotes	signal
T23196	44083-44087	IN	denotes	from
T23197	44088-44102	NNS	denotes	photoreceptors
T23198	44103-44105	IN	denotes	to
T23199	44106-44113	JJ	denotes	bipolar
T23200	44127-44132	NNS	denotes	cells
T23201	44114-44117	CC	denotes	and
T23202	44118-44126	JJ	denotes	amacrine
T23203	44132-44133	.	denotes	.
T23204	44133-44261	sentence	denotes	Division and death genes were induced in Rb KO cells, and deleting E2f1, but not E2f2 or E2f3, reversed these molecular events.
T23205	44134-44142	NN	denotes	Division
T23206	44153-44158	NNS	denotes	genes
T23207	44143-44146	CC	denotes	and
T23208	44147-44152	NN	denotes	death
T23209	44164-44171	VBN	denotes	induced
T23210	44159-44163	VBD	denotes	were
T23211	44172-44174	IN	denotes	in
T23212	44175-44177	NN	denotes	Rb
T23213	44178-44180	NN	denotes	KO
T23214	44181-44186	NNS	denotes	cells
T23215	44186-44188	,	denotes	,
T23216	44188-44191	CC	denotes	and
T23217	44192-44200	VBG	denotes	deleting
T23218	44229-44237	VBD	denotes	reversed
T23219	44201-44205	NN	denotes	E2f1
T23220	44205-44207	,	denotes	,
T23221	44207-44210	CC	denotes	but
T23222	44211-44214	RB	denotes	not
T23223	44215-44219	NN	denotes	E2f2
T23224	44220-44222	CC	denotes	or
T23225	44223-44227	NN	denotes	E2f3
T23226	44227-44229	,	denotes	,
T23227	44238-44243	DT	denotes	these
T23228	44254-44260	NNS	denotes	events
T23229	44244-44253	JJ	denotes	molecular
T23230	44260-44261	.	denotes	.
T23231	44261-44476	sentence	denotes	E2f1 may also regulate differentiation targets, but whether this contributes to defects in retinal cell maturation is impossible to separate from potentially indirect consequences of deregulated division and death.
T23232	44262-44266	NN	denotes	E2f1
T23233	44276-44284	VB	denotes	regulate
T23234	44267-44270	MD	denotes	may
T23235	44271-44275	RB	denotes	also
T23236	44285-44300	NN	denotes	differentiation
T23237	44301-44308	NNS	denotes	targets
T23238	44308-44310	,	denotes	,
T23239	44310-44313	CC	denotes	but
T23240	44314-44321	IN	denotes	whether
T23241	44327-44338	VBZ	denotes	contributes
T23242	44322-44326	DT	denotes	this
T23243	44377-44379	VBZ	denotes	is
T23244	44339-44341	IN	denotes	to
T23245	44342-44349	NNS	denotes	defects
T23246	44350-44352	IN	denotes	in
T23247	44353-44360	JJ	denotes	retinal
T23248	44361-44365	NN	denotes	cell
T23249	44366-44376	NN	denotes	maturation
T23250	44380-44390	JJ	denotes	impossible
T23251	44391-44393	TO	denotes	to
T23252	44394-44402	VB	denotes	separate
T23253	44403-44407	IN	denotes	from
T23254	44408-44419	RB	denotes	potentially
T23255	44420-44428	JJ	denotes	indirect
T23256	44429-44441	NNS	denotes	consequences
T23257	44442-44444	IN	denotes	of
T23258	44445-44456	VBN	denotes	deregulated
T23259	44457-44465	NN	denotes	division
T23260	44466-44469	CC	denotes	and
T23261	44470-44475	NN	denotes	death
T23262	44475-44476	.	denotes	.
T23263	44476-44641	sentence	denotes	In any case, it is clear that in most retinal cells, including photoreceptors [29], transcription factors that promote differentiation function independently of Rb.
T23264	44477-44479	IN	denotes	In
T23265	44493-44495	VBZ	denotes	is
T23266	44480-44483	DT	denotes	any
T23267	44484-44488	NN	denotes	case
T23268	44488-44490	,	denotes	,
T23269	44490-44492	PRP	denotes	it
T23270	44496-44501	JJ	denotes	clear
T23271	44502-44506	IN	denotes	that
T23272	44612-44620	VBZ	denotes	function
T23273	44507-44509	IN	denotes	in
T23274	44510-44514	JJS	denotes	most
T23275	44523-44528	NNS	denotes	cells
T23276	44515-44522	JJ	denotes	retinal
T23277	44528-44530	,	denotes	,
T23278	44530-44539	VBG	denotes	including
T23279	44540-44554	NNS	denotes	photoreceptors
T23280	44555-44556	-LRB-	denotes	[
T23281	44556-44558	CD	denotes	29
T23282	44558-44559	-RRB-	denotes	]
T23283	44559-44561	,	denotes	,
T23284	44561-44574	NN	denotes	transcription
T23285	44575-44582	NNS	denotes	factors
T23286	44583-44587	WDT	denotes	that
T23287	44588-44595	VBP	denotes	promote
T23288	44596-44611	NN	denotes	differentiation
T23289	44621-44634	RB	denotes	independently
T23290	44635-44637	IN	denotes	of
T23291	44638-44640	NN	denotes	Rb
T23292	44640-44641	.	denotes	.
T23293	44641-44858	sentence	denotes	We have also found that E2f1 deletion rescues cell-autonomous ectopic division, death, and differentiation defects in sporadic Rb KO clones generated using a Cre retrovirus vector (M. P. and R. B., unpublished data).
T23294	44642-44644	PRP	denotes	We
T23295	44655-44660	VBN	denotes	found
T23296	44645-44649	VBP	denotes	have
T23297	44650-44654	RB	denotes	also
T23298	44661-44665	IN	denotes	that
T23299	44680-44687	VBZ	denotes	rescues
T23300	44666-44670	NN	denotes	E2f1
T23301	44671-44679	NN	denotes	deletion
T23302	44688-44692	NN	denotes	cell
T23303	44693-44703	JJ	denotes	autonomous
T23304	44692-44693	HYPH	denotes	-
T23305	44712-44720	NN	denotes	division
T23306	44704-44711	JJ	denotes	ectopic
T23307	44720-44722	,	denotes	,
T23308	44722-44727	NN	denotes	death
T23309	44727-44729	,	denotes	,
T23310	44729-44732	CC	denotes	and
T23311	44733-44748	NN	denotes	differentiation
T23312	44749-44756	NNS	denotes	defects
T23313	44757-44759	IN	denotes	in
T23314	44760-44768	JJ	denotes	sporadic
T23315	44775-44781	NNS	denotes	clones
T23316	44769-44771	NN	denotes	Rb
T23317	44772-44774	NN	denotes	KO
T23318	44782-44791	VBN	denotes	generated
T23319	44792-44797	VBG	denotes	using
T23320	44798-44799	DT	denotes	a
T23321	44815-44821	NN	denotes	vector
T23322	44800-44803	NN	denotes	Cre
T23323	44804-44814	NN	denotes	retrovirus
T23324	44822-44823	-LRB-	denotes	(
T23325	44823-44825	NNP	denotes	M.
T23326	44826-44828	NNP	denotes	P.
T23327	44829-44832	CC	denotes	and
T23328	44833-44835	NNP	denotes	R.
T23329	44836-44838	NNP	denotes	B.
T23330	44838-44840	,	denotes	,
T23331	44840-44851	JJ	denotes	unpublished
T23332	44852-44856	NNS	denotes	data
T23333	44856-44857	-RRB-	denotes	)
T23334	44857-44858	.	denotes	.
T23335	44858-45174	sentence	denotes	These data are consistent with the observation that E2f1 overexpression in newborn photoreceptors drives ectopic division and apoptosis [60], and add to the growing evidence indicating that E2f1 is the major, and perhaps only, member of the three activating E2fs required to induce apoptosis in Rb KO cells [10,15].
T23336	44859-44864	DT	denotes	These
T23337	44865-44869	NNS	denotes	data
T23338	44870-44873	VBP	denotes	are
T23339	44874-44884	JJ	denotes	consistent
T23340	44885-44889	IN	denotes	with
T23341	44890-44893	DT	denotes	the
T23342	44894-44905	NN	denotes	observation
T23343	44906-44910	IN	denotes	that
T23344	44957-44963	VBZ	denotes	drives
T23345	44911-44915	NN	denotes	E2f1
T23346	44916-44930	NN	denotes	overexpression
T23347	44931-44933	IN	denotes	in
T23348	44934-44941	JJ	denotes	newborn
T23349	44942-44956	NNS	denotes	photoreceptors
T23350	44964-44971	JJ	denotes	ectopic
T23351	44972-44980	NN	denotes	division
T23352	44981-44984	CC	denotes	and
T23353	44985-44994	NN	denotes	apoptosis
T23354	44995-44996	-LRB-	denotes	[
T23355	44996-44998	CD	denotes	60
T23356	44998-44999	-RRB-	denotes	]
T23357	44999-45001	,	denotes	,
T23358	45001-45004	CC	denotes	and
T23359	45005-45008	VBP	denotes	add
T23360	45009-45011	IN	denotes	to
T23361	45012-45015	DT	denotes	the
T23362	45024-45032	NN	denotes	evidence
T23363	45016-45023	VBG	denotes	growing
T23364	45033-45043	VBG	denotes	indicating
T23365	45044-45048	IN	denotes	that
T23366	45054-45056	VBZ	denotes	is
T23367	45049-45053	NN	denotes	E2f1
T23368	45057-45060	DT	denotes	the
T23369	45086-45092	NN	denotes	member
T23370	45061-45066	JJ	denotes	major
T23371	45066-45068	,	denotes	,
T23372	45068-45071	CC	denotes	and
T23373	45072-45079	RB	denotes	perhaps
T23374	45080-45084	JJ	denotes	only
T23375	45084-45086	,	denotes	,
T23376	45093-45095	IN	denotes	of
T23377	45096-45099	DT	denotes	the
T23378	45117-45121	NNS	denotes	E2fs
T23379	45100-45105	CD	denotes	three
T23380	45106-45116	VBG	denotes	activating
T23381	45122-45130	VBN	denotes	required
T23382	45131-45133	TO	denotes	to
T23383	45134-45140	VB	denotes	induce
T23384	45141-45150	NN	denotes	apoptosis
T23385	45151-45153	IN	denotes	in
T23386	45154-45156	NN	denotes	Rb
T23387	45157-45159	NN	denotes	KO
T23388	45160-45165	NNS	denotes	cells
T23389	45166-45167	-LRB-	denotes	[
T23390	45170-45172	CD	denotes	15
T23391	45167-45169	CD	denotes	10
T23392	45169-45170	,	denotes	,
T23393	45172-45173	-RRB-	denotes	]
T23394	45173-45174	.	denotes	.
T23395	45174-45370	sentence	denotes	Thus, deregulated E2f1 activity in the retina, whether resulting from the inactivation of Rb or from overexpression, promotes unscheduled cell division and triggers apoptosis in susceptible RTCs.
T23396	45175-45179	RB	denotes	Thus
T23397	45292-45300	VBZ	denotes	promotes
T23398	45179-45181	,	denotes	,
T23399	45181-45192	VBN	denotes	deregulated
T23400	45198-45206	NN	denotes	activity
T23401	45193-45197	NN	denotes	E2f1
T23402	45207-45209	IN	denotes	in
T23403	45210-45213	DT	denotes	the
T23404	45214-45220	NN	denotes	retina
T23405	45220-45222	,	denotes	,
T23406	45222-45229	IN	denotes	whether
T23407	45230-45239	VBG	denotes	resulting
T23408	45240-45244	IN	denotes	from
T23409	45245-45248	DT	denotes	the
T23410	45249-45261	NN	denotes	inactivation
T23411	45262-45264	IN	denotes	of
T23412	45265-45267	NN	denotes	Rb
T23413	45268-45270	CC	denotes	or
T23414	45271-45275	IN	denotes	from
T23415	45276-45290	NN	denotes	overexpression
T23416	45290-45292	,	denotes	,
T23417	45301-45312	JJ	denotes	unscheduled
T23418	45318-45326	NN	denotes	division
T23419	45313-45317	NN	denotes	cell
T23420	45327-45330	CC	denotes	and
T23421	45331-45339	VBZ	denotes	triggers
T23422	45340-45349	NN	denotes	apoptosis
T23423	45350-45352	IN	denotes	in
T23424	45353-45364	JJ	denotes	susceptible
T23425	45365-45369	NNS	denotes	RTCs
T23426	45369-45370	.	denotes	.
T23427	45370-45494	sentence	denotes	E2f1, rather than other E2fs, may be a potential target for novel therapeutics to prevent retinoblastoma in RB1 +/− humans.
T23428	45371-45375	NN	denotes	E2f1
T23429	45405-45407	VB	denotes	be
T23430	45375-45377	,	denotes	,
T23431	45377-45383	RB	denotes	rather
T23432	45384-45388	IN	denotes	than
T23433	45389-45394	JJ	denotes	other
T23434	45395-45399	NNS	denotes	E2fs
T23435	45399-45401	,	denotes	,
T23436	45401-45404	MD	denotes	may
T23437	45408-45409	DT	denotes	a
T23438	45420-45426	NN	denotes	target
T23439	45410-45419	JJ	denotes	potential
T23440	45427-45430	IN	denotes	for
T23441	45431-45436	JJ	denotes	novel
T23442	45437-45449	NNS	denotes	therapeutics
T23443	45450-45452	TO	denotes	to
T23444	45453-45460	VB	denotes	prevent
T23445	45461-45475	NN	denotes	retinoblastoma
T23446	45476-45478	IN	denotes	in
T23447	45479-45482	NN	denotes	RB1
T23448	45487-45493	NNS	denotes	humans
T23449	45483-45484	SYM	denotes	+
T23450	45484-45485	HYPH	denotes	/
T23451	45485-45486	SYM	denotes	−
T23452	45493-45494	.	denotes	.
T23453	45494-45643	sentence	denotes	Our ERG studies revealed rescue of the Rb KO rod–bipolar system, and almost complete restoration of the cone–bipolar system following E2f1 deletion.
T23454	45495-45498	PRP$	denotes	Our
T23455	45503-45510	NNS	denotes	studies
T23456	45499-45502	NN	denotes	ERG
T23457	45511-45519	VBD	denotes	revealed
T23458	45520-45526	NN	denotes	rescue
T23459	45527-45529	IN	denotes	of
T23460	45530-45533	DT	denotes	the
T23461	45552-45558	NN	denotes	system
T23462	45534-45536	NN	denotes	Rb
T23463	45537-45539	NN	denotes	KO
T23466	45543-45544	HYPH	denotes	–
T23467	45558-45560	,	denotes	,
T23468	45560-45563	CC	denotes	and
T23469	45564-45570	RB	denotes	almost
T23470	45571-45579	JJ	denotes	complete
T23471	45580-45591	NN	denotes	restoration
T23472	45592-45594	IN	denotes	of
T23473	45595-45598	DT	denotes	the
T23474	45612-45618	NN	denotes	system
T23475	45599-45603	NN	denotes	cone
T23476	45604-45611	JJ	denotes	bipolar
T23477	45603-45604	HYPH	denotes	–
T23478	45619-45628	VBG	denotes	following
T23479	45629-45633	NN	denotes	E2f1
T23480	45634-45642	NN	denotes	deletion
T23481	45642-45643	.	denotes	.
T23482	45643-45745	sentence	denotes	There was a slightly lower response in the Rb/E2f1 DKO retina relative to the E2f1 KO control retina.
T23483	45644-45649	EX	denotes	There
T23484	45650-45653	VBD	denotes	was
T23485	45654-45655	DT	denotes	a
T23486	45671-45679	NN	denotes	response
T23487	45656-45664	RB	denotes	slightly
T23488	45665-45670	JJR	denotes	lower
T23489	45680-45682	IN	denotes	in
T23490	45683-45686	DT	denotes	the
T23491	45699-45705	NN	denotes	retina
T23492	45687-45689	NN	denotes	Rb
T23493	45690-45694	NN	denotes	E2f1
T23494	45689-45690	HYPH	denotes	/
T23495	45695-45698	NN	denotes	DKO
T23496	45706-45714	JJ	denotes	relative
T23497	45715-45717	IN	denotes	to
T23498	45718-45721	DT	denotes	the
T23499	45738-45744	NN	denotes	retina
T23500	45722-45726	NN	denotes	E2f1
T23501	45727-45729	NN	denotes	KO
T23502	45730-45737	NN	denotes	control
T23503	45744-45745	.	denotes	.
T23504	45745-45975	sentence	denotes	This difference might reflect a role for Rb in the development of cones, bipolar cells, or other cells that may contribute to the photopic ERG, including potentially SACs, which do have a serious defect in the Rb/E2f1 DKO retina.
T23505	45746-45750	DT	denotes	This
T23506	45751-45761	NN	denotes	difference
T23507	45768-45775	VB	denotes	reflect
T23508	45762-45767	MD	denotes	might
T23509	45776-45777	DT	denotes	a
T23510	45778-45782	NN	denotes	role
T23511	45783-45786	IN	denotes	for
T23512	45787-45789	NN	denotes	Rb
T23513	45790-45792	IN	denotes	in
T23514	45793-45796	DT	denotes	the
T23515	45797-45808	NN	denotes	development
T23516	45809-45811	IN	denotes	of
T23517	45812-45817	NNS	denotes	cones
T23518	45817-45819	,	denotes	,
T23519	45819-45826	JJ	denotes	bipolar
T23520	45827-45832	NNS	denotes	cells
T23521	45832-45834	,	denotes	,
T23522	45834-45836	CC	denotes	or
T23523	45837-45842	JJ	denotes	other
T23524	45843-45848	NNS	denotes	cells
T23525	45849-45853	WDT	denotes	that
T23526	45858-45868	VB	denotes	contribute
T23527	45854-45857	MD	denotes	may
T23528	45869-45871	IN	denotes	to
T23529	45872-45875	DT	denotes	the
T23530	45885-45888	NN	denotes	ERG
T23531	45876-45884	JJ	denotes	photopic
T23532	45888-45890	,	denotes	,
T23533	45890-45899	VBG	denotes	including
T23534	45900-45911	RB	denotes	potentially
T23535	45912-45916	NNS	denotes	SACs
T23536	45916-45918	,	denotes	,
T23537	45918-45923	WDT	denotes	which
T23538	45927-45931	VB	denotes	have
T23539	45924-45926	VBP	denotes	do
T23540	45932-45933	DT	denotes	a
T23541	45942-45948	NN	denotes	defect
T23542	45934-45941	JJ	denotes	serious
T23543	45949-45951	IN	denotes	in
T23544	45952-45955	DT	denotes	the
T23545	45968-45974	NN	denotes	retina
T23546	45956-45958	NN	denotes	Rb
T23547	45959-45963	NN	denotes	E2f1
T23548	45958-45959	HYPH	denotes	/
T23549	45964-45967	NN	denotes	DKO
T23550	45974-45975	.	denotes	.
T29766	55470-55472	,	denotes	,
T24609	45977-45979	NN	denotes	Rb
T24610	45980-45988	VBZ	denotes	Controls
T24611	45989-45992	NN	denotes	SAC
T24612	45993-46008	NN	denotes	Differentiation
T24613	46009-46016	IN	denotes	through
T24614	46017-46022	NN	denotes	E2f3a
T24615	46022-46180	sentence	denotes	Comprehensive marker analysis revealed that, in striking contrast to other retinal neurons, E2f1 deletion did not suppress defects in Rb KO cholinergic SACs.
T24616	46023-46036	JJ	denotes	Comprehensive
T24617	46044-46052	NN	denotes	analysis
T24618	46037-46043	NN	denotes	marker
T24619	46053-46061	VBD	denotes	revealed
T24620	46062-46066	IN	denotes	that
T24621	46137-46145	VB	denotes	suppress
T24622	46066-46068	,	denotes	,
T24623	46068-46070	IN	denotes	in
T24624	46071-46079	JJ	denotes	striking
T24625	46080-46088	NN	denotes	contrast
T24626	46089-46091	IN	denotes	to
T24627	46092-46097	JJ	denotes	other
T24628	46106-46113	NNS	denotes	neurons
T24629	46098-46105	JJ	denotes	retinal
T24630	46113-46115	,	denotes	,
T24631	46115-46119	NN	denotes	E2f1
T24632	46120-46128	NN	denotes	deletion
T24633	46129-46132	VBD	denotes	did
T24634	46133-46136	RB	denotes	not
T24635	46146-46153	NNS	denotes	defects
T24636	46154-46156	IN	denotes	in
T24637	46157-46159	NN	denotes	Rb
T24638	46160-46162	NN	denotes	KO
T24639	46175-46179	NNS	denotes	SACs
T24640	46163-46174	JJ	denotes	cholinergic
T24641	46179-46180	.	denotes	.
T24642	46180-46292	sentence	denotes	Instead, we observed E2f1-independent defects in the synthesis and transport of a large cohort of SAC proteins.
T24643	46181-46188	RB	denotes	Instead
T24644	46193-46201	VBD	denotes	observed
T24645	46188-46190	,	denotes	,
T24646	46190-46192	PRP	denotes	we
T24647	46202-46206	NN	denotes	E2f1
T24648	46207-46218	JJ	denotes	independent
T24649	46206-46207	HYPH	denotes	-
T24650	46219-46226	NNS	denotes	defects
T24651	46227-46229	IN	denotes	in
T24652	46230-46233	DT	denotes	the
T24653	46234-46243	NN	denotes	synthesis
T24654	46244-46247	CC	denotes	and
T24655	46248-46257	NN	denotes	transport
T24656	46258-46260	IN	denotes	of
T24657	46261-46262	DT	denotes	a
T24658	46269-46275	NN	denotes	cohort
T24659	46263-46268	JJ	denotes	large
T24660	46276-46278	IN	denotes	of
T24661	46279-46282	NN	denotes	SAC
T24662	46283-46291	NN	denotes	proteins
T24663	46291-46292	.	denotes	.
T24664	46292-46505	sentence	denotes	These data expand insight into the development of these important interneurons, but more critically, provide to our knowledge the first unambiguous evidence that Rb regulates neurogenesis beyond terminal mitosis.
T24665	46293-46298	DT	denotes	These
T24666	46299-46303	NNS	denotes	data
T24667	46304-46310	VBP	denotes	expand
T24668	46311-46318	NN	denotes	insight
T24669	46319-46323	IN	denotes	into
T24670	46324-46327	DT	denotes	the
T24671	46328-46339	NN	denotes	development
T24672	46340-46342	IN	denotes	of
T24673	46343-46348	DT	denotes	these
T24674	46359-46371	NNS	denotes	interneurons
T24675	46349-46358	JJ	denotes	important
T24676	46371-46373	,	denotes	,
T24677	46373-46376	CC	denotes	but
T24678	46377-46381	RBR	denotes	more
T24679	46382-46392	RB	denotes	critically
T24680	46394-46401	VB	denotes	provide
T24681	46392-46394	,	denotes	,
T24682	46402-46404	IN	denotes	to
T24683	46405-46408	PRP$	denotes	our
T24684	46409-46418	NN	denotes	knowledge
T24685	46419-46422	DT	denotes	the
T24686	46441-46449	NN	denotes	evidence
T24687	46423-46428	JJ	denotes	first
T24688	46429-46440	JJ	denotes	unambiguous
T24689	46450-46454	IN	denotes	that
T24690	46458-46467	VBZ	denotes	regulates
T24691	46455-46457	NN	denotes	Rb
T24692	46468-46480	NN	denotes	neurogenesis
T24693	46481-46487	IN	denotes	beyond
T24694	46488-46496	JJ	denotes	terminal
T24695	46497-46504	NN	denotes	mitosis
T24696	46504-46505	.	denotes	.
T24697	46505-46725	sentence	denotes	Rb binds more than 100 factors [43], and in several non-neuronal cells, such as skeletal muscle, adipocytes, and bone, it binds and potentiates tissue-specific transcription factors that promote differentiation [31–33].
T24698	46506-46508	NN	denotes	Rb
T24699	46509-46514	VBZ	denotes	binds
T24700	46515-46519	JJR	denotes	more
T24701	46525-46528	CD	denotes	100
T24702	46520-46524	IN	denotes	than
T24703	46529-46536	NNS	denotes	factors
T24704	46537-46538	-LRB-	denotes	[
T24705	46538-46540	CD	denotes	43
T24706	46540-46541	-RRB-	denotes	]
T24707	46541-46543	,	denotes	,
T24708	46543-46546	CC	denotes	and
T24709	46547-46549	IN	denotes	in
T24710	46628-46633	VBZ	denotes	binds
T24711	46550-46557	JJ	denotes	several
T24712	46571-46576	NNS	denotes	cells
T24713	46558-46570	JJ	denotes	non-neuronal
T24714	46576-46578	,	denotes	,
T24715	46578-46582	JJ	denotes	such
T24716	46583-46585	IN	denotes	as
T24738	46720-46721	SYM	denotes	–
T24739	46721-46723	CD	denotes	33
T24740	46723-46724	-RRB-	denotes	]
T24741	46724-46725	.	denotes	.
T24742	46725-46898	sentence	denotes	The idea that Rb promotes muscle differentiation by potentiating Myod1 activity was contested [61], and other mechanisms proposed [62,63], but not involving E2f repression.
T24743	46726-46729	DT	denotes	The
T24744	46730-46734	NN	denotes	idea
T24745	46810-46819	VBN	denotes	contested
T24746	46735-46739	IN	denotes	that
T24747	46743-46751	VBZ	denotes	promotes
T24748	46740-46742	NN	denotes	Rb
T24749	46752-46758	NN	denotes	muscle
T24750	46759-46774	NN	denotes	differentiation
T24751	46775-46777	IN	denotes	by
T24752	46778-46790	VBG	denotes	potentiating
T24753	46791-46796	NN	denotes	Myod1
T24754	46797-46805	NN	denotes	activity
T24755	46806-46809	VBD	denotes	was
T24756	46820-46821	-LRB-	denotes	[
T24757	46821-46823	CD	denotes	61
T24758	46823-46824	-RRB-	denotes	]
T24759	46824-46826	,	denotes	,
T24760	46826-46829	CC	denotes	and
T24761	46830-46835	JJ	denotes	other
T24762	46836-46846	NNS	denotes	mechanisms
T24763	46847-46855	VBN	denotes	proposed
T24764	46856-46857	-LRB-	denotes	[
T24765	46860-46862	CD	denotes	63
T24766	46857-46859	CD	denotes	62
T24767	46859-46860	,	denotes	,
T24768	46862-46863	-RRB-	denotes	]
T24769	46863-46865	,	denotes	,
T24770	46865-46868	CC	denotes	but
T24771	46873-46882	VBG	denotes	involving
T24772	46869-46872	RB	denotes	not
T24773	46883-46886	NN	denotes	E2f
T24774	46887-46897	NN	denotes	repression
T24775	46897-46898	.	denotes	.
T24776	46898-46995	sentence	denotes	Strikingly, however, we discovered that Rb promotes SAC differentiation through E2f3 (Figure 8).
T24777	46899-46909	RB	denotes	Strikingly
T24778	46923-46933	VBD	denotes	discovered
T24779	46909-46911	,	denotes	,
T24780	46911-46918	RB	denotes	however
T24781	46918-46920	,	denotes	,
T24782	46920-46922	PRP	denotes	we
T24783	46934-46938	IN	denotes	that
T24784	46942-46950	VBZ	denotes	promotes
T24785	46939-46941	NN	denotes	Rb
T24786	46951-46954	NN	denotes	SAC
T24787	46955-46970	NN	denotes	differentiation
T24788	46971-46978	IN	denotes	through
T24789	46979-46983	NN	denotes	E2f3
T24790	46984-46985	-LRB-	denotes	(
T24791	46985-46991	NN	denotes	Figure
T24792	46992-46993	CD	denotes	8
T24793	46993-46994	-RRB-	denotes	)
T24794	46994-46995	.	denotes	.
T24795	46995-46996	sentence	denotes
T24796	47006-47012	sentence	denotes	Rb Reg
T24797	47006-47008	NN	denotes	Rb
T24798	47009-47011	NNS	denotes	Re
T24799	47011-47012	IN	denotes	g
T24826	47748-47751	PRP$	denotes	its
T24827	47752-47756	NN	denotes	role
T24828	47757-47759	IN	denotes	in
T24829	47760-47771	VBG	denotes	controlling
T24830	47772-47780	NN	denotes	division
T24831	47781-47783	CC	denotes	or
T24832	47784-47789	NN	denotes	death
T24833	47789-47791	:	denotes	:
T24834	47791-47795	NN	denotes	E2f3
T24835	47796-47804	NN	denotes	deletion
T24836	47813-47815	NN	denotes	Rb
T24837	47816-47818	NN	denotes	KO
T24838	47823-47830	NNS	denotes	defects
T24839	47819-47822	NN	denotes	SAC
T24840	47831-47834	CC	denotes	but
T24841	47835-47838	VBD	denotes	did
T24842	47843-47851	VB	denotes	suppress
T24843	47839-47842	RB	denotes	not
T24844	47852-47860	JJ	denotes	aberrant
T24845	47861-47874	NN	denotes	proliferation
T24846	47875-47877	CC	denotes	or
T24847	47878-47883	NN	denotes	death
T24848	47883-47885	,	denotes	,
T24849	47885-47892	IN	denotes	whereas
T24850	47907-47915	VBD	denotes	reversed
T24851	47893-47897	NN	denotes	E2f1
T24852	47898-47906	NN	denotes	deletion
T24853	47916-47924	JJ	denotes	abnormal
T24854	47925-47938	NN	denotes	proliferation
T24855	47939-47942	CC	denotes	and
T24856	47943-47948	NN	denotes	death
T24857	47949-47952	CC	denotes	but
T24858	47953-47956	VBD	denotes	did
T24859	47961-47967	VB	denotes	rescue
T24860	47957-47960	RB	denotes	not
T24861	47968-47971	NN	denotes	SAC
T24862	47972-47987	NN	denotes	differentiation
T24863	47987-47988	.	denotes	.
T24864	47988-48076	sentence	denotes	Double labelling confirmed that E2f1 but not E2f3 deletion reversed Rb KO SAC division.
T24865	47989-47995	JJ	denotes	Double
T24866	47996-48005	NN	denotes	labelling
T24867	48006-48015	VBD	denotes	confirmed
T24868	48016-48020	IN	denotes	that
T24869	48048-48056	VBD	denotes	reversed
T24870	48021-48025	NN	denotes	E2f1
T24871	48039-48047	NN	denotes	deletion
T24872	48026-48029	CC	denotes	but
T24873	48030-48033	RB	denotes	not
T24874	48034-48038	NN	denotes	E2f3
T24875	48057-48059	NN	denotes	Rb
T24876	48060-48062	NN	denotes	KO
T24877	48063-48066	NN	denotes	SAC
T24878	48067-48075	NN	denotes	division
T24879	48075-48076	.	denotes	.
T24880	48076-48202	sentence	denotes	Moreover, deleting E2f1, but not E2f3, reversed deregulated expression of cell cycle and apoptotic genes in the Rb KO retina.
T24881	48077-48085	RB	denotes	Moreover
T24882	48116-48124	VBD	denotes	reversed
T24883	48085-48087	,	denotes	,
T24884	48087-48095	VBG	denotes	deleting
T24885	48096-48100	NN	denotes	E2f1
T24886	48100-48102	,	denotes	,
T24887	48102-48105	CC	denotes	but
T24888	48106-48109	RB	denotes	not
T24889	48110-48114	NN	denotes	E2f3
T24890	48114-48116	,	denotes	,
T24891	48125-48136	VBN	denotes	deregulated
T24892	48137-48147	NN	denotes	expression
T24893	48148-48150	IN	denotes	of
T24894	48151-48155	NN	denotes	cell
T24895	48156-48161	NN	denotes	cycle
T24896	48162-48165	CC	denotes	and
T24897	48166-48175	JJ	denotes	apoptotic
T24898	48176-48181	NNS	denotes	genes
T24899	48182-48184	IN	denotes	in
T24900	48185-48188	DT	denotes	the
T24901	48195-48201	NN	denotes	retina
T24902	48189-48191	NN	denotes	Rb
T24903	48192-48194	NN	denotes	KO
T24904	48201-48202	.	denotes	.
T24905	48202-48343	sentence	denotes	E2f3 is expressed in a subset of CNS neurons (this work) and drives specific cell-cycle–independent defects in Rb KO forebrain neurons [53].
T24906	48203-48207	NN	denotes	E2f3
T24907	48211-48220	VBN	denotes	expressed
T24908	48208-48210	VBZ	denotes	is
T24909	48221-48223	IN	denotes	in
T24910	48224-48225	DT	denotes	a
T24911	48226-48232	NN	denotes	subset
T24912	48233-48235	IN	denotes	of
T24913	48236-48239	NN	denotes	CNS
T24914	48240-48247	NNS	denotes	neurons
T24915	48248-48249	-LRB-	denotes	(
T24916	48254-48258	NN	denotes	work
T24917	48249-48253	DT	denotes	this
T24918	48258-48259	-RRB-	denotes	)
T24919	48260-48263	CC	denotes	and
T24920	48264-48270	VBZ	denotes	drives
T24921	48271-48279	JJ	denotes	specific
T24922	48303-48310	NNS	denotes	defects
T24923	48280-48284	NN	denotes	cell
T24924	48285-48290	NN	denotes	cycle
T24925	48284-48285	HYPH	denotes	-
T24926	48291-48302	JJ	denotes	independent
T24927	48290-48291	HYPH	denotes	–
T24928	48311-48313	IN	denotes	in
T24929	48314-48316	NN	denotes	Rb
T24930	48317-48319	NN	denotes	KO
T24931	48330-48337	NNS	denotes	neurons
T24932	48320-48329	NN	denotes	forebrain
T24933	48338-48339	-LRB-	denotes	[
T24934	48339-48341	CD	denotes	53
T24935	48341-48342	-RRB-	denotes	]
T24936	48342-48343	.	denotes	.
T24937	48343-48473	sentence	denotes	Thus, E2f3 inhibition is the first, and may be the only, mechanism by which Rb participates directly in neuronal differentiation.
T24938	48344-48348	RB	denotes	Thus
T24939	48366-48368	VBZ	denotes	is
T24940	48348-48350	,	denotes	,
T24941	48350-48354	NN	denotes	E2f3
T24942	48355-48365	NN	denotes	inhibition
T24943	48369-48372	DT	denotes	the
T24944	48373-48378	JJ	denotes	first
T24945	48378-48380	,	denotes	,
T24946	48380-48383	CC	denotes	and
T24947	48384-48387	MD	denotes	may
T24948	48388-48390	VB	denotes	be
T24949	48391-48394	DT	denotes	the
T24950	48395-48399	JJ	denotes	only
T24951	48399-48401	,	denotes	,
T24952	48401-48410	NN	denotes	mechanism
T24953	48411-48413	IN	denotes	by
T24954	48423-48435	VBZ	denotes	participates
T24955	48414-48419	WDT	denotes	which
T24956	48420-48422	NN	denotes	Rb
T24957	48436-48444	RB	denotes	directly
T24958	48445-48447	IN	denotes	in
T24959	48448-48456	JJ	denotes	neuronal
T24960	48457-48472	NN	denotes	differentiation
T24961	48472-48473	.	denotes	.
T24962	48473-48600	sentence	denotes	To further dissect the mechanism of action of Rb in SACs we determined the E2f3 isoform it targets to promote differentiation.
T24963	48474-48476	TO	denotes	To
T24964	48485-48492	VB	denotes	dissect
T24965	48477-48484	RB	denotes	further
T24966	48534-48544	VBD	denotes	determined
T24967	48493-48496	DT	denotes	the
T24968	48497-48506	NN	denotes	mechanism
T24969	48507-48509	IN	denotes	of
T24970	48510-48516	NN	denotes	action
T24971	48517-48519	IN	denotes	of
T24972	48520-48522	NN	denotes	Rb
T24973	48523-48525	IN	denotes	in
T24974	48526-48530	NNS	denotes	SACs
T24975	48531-48533	PRP	denotes	we
T24976	48545-48548	DT	denotes	the
T24977	48554-48561	NN	denotes	isoform
T24978	48549-48553	NN	denotes	E2f3
T24979	48562-48564	PRP	denotes	it
T24980	48565-48572	VBZ	denotes	targets
T24981	48573-48575	TO	denotes	to
T24982	48576-48583	VB	denotes	promote
T24983	48584-48599	NN	denotes	differentiation
T24984	48599-48600	.	denotes	.
T24985	48600-48717	sentence	denotes	E2f3b was the primary candidate, since Rb and E2f3b collaborate to repress targets in quiescent cells in vitro [19].
T24986	48601-48606	NN	denotes	E2f3b
T24987	48607-48610	VBD	denotes	was
T24988	48611-48614	DT	denotes	the
T24989	48623-48632	NN	denotes	candidate
T24990	48615-48622	JJ	denotes	primary
T24991	48632-48634	,	denotes	,
T24992	48634-48639	IN	denotes	since
T24993	48653-48664	VBP	denotes	collaborate
T24994	48640-48642	NN	denotes	Rb
T24995	48643-48646	CC	denotes	and
T24996	48647-48652	NN	denotes	E2f3b
T24997	48665-48667	TO	denotes	to
T24998	48668-48675	VB	denotes	repress
T24999	48676-48683	NNS	denotes	targets
T25000	48684-48686	IN	denotes	in
T25001	48687-48696	JJ	denotes	quiescent
T25002	48697-48702	NNS	denotes	cells
T25003	48703-48705	FW	denotes	in
T25004	48706-48711	FW	denotes	vitro
T25005	48712-48713	-LRB-	denotes	[
T25006	48713-48715	CD	denotes	19
T25007	48715-48716	-RRB-	denotes	]
T25008	48716-48717	.	denotes	.
T25009	48717-48920	sentence	denotes	However, in the first work to our knowledge to examine the function of any E2f protein isoform in vivo, we made the surprising observation that Rb regulates SAC differentiation through E2f3a (Figure 8).
T25010	48718-48725	RB	denotes	However
T25011	48825-48829	VBD	denotes	made
T25012	48725-48727	,	denotes	,
T25013	48727-48729	IN	denotes	in
T25014	48730-48733	DT	denotes	the
T25015	48740-48744	NN	denotes	work
T25016	48734-48739	JJ	denotes	first
T25017	48745-48747	IN	denotes	to
T25018	48765-48772	VB	denotes	examine
T25019	48748-48751	PRP$	denotes	our
T25020	48752-48761	NN	denotes	knowledge
T25021	48762-48764	TO	denotes	to
T25022	48773-48776	DT	denotes	the
T25023	48777-48785	NN	denotes	function
T25024	48786-48788	IN	denotes	of
T25025	48789-48792	DT	denotes	any
T25026	48805-48812	NN	denotes	isoform
T25027	48793-48796	NN	denotes	E2f
T25028	48797-48804	NN	denotes	protein
T25029	48813-48815	FW	denotes	in
T25030	48816-48820	FW	denotes	vivo
T25031	48820-48822	,	denotes	,
T25032	48822-48824	PRP	denotes	we
T25033	48830-48833	DT	denotes	the
T25034	48845-48856	NN	denotes	observation
T25035	48834-48844	JJ	denotes	surprising
T25036	48857-48861	IN	denotes	that
T25037	48865-48874	VBZ	denotes	regulates
T25038	48862-48864	NN	denotes	Rb
T25039	48875-48878	NN	denotes	SAC
T25040	48879-48894	NN	denotes	differentiation
T25041	48895-48902	IN	denotes	through
T25042	48903-48908	NN	denotes	E2f3a
T25043	48909-48910	-LRB-	denotes	(
T25044	48910-48916	NN	denotes	Figure
T25045	48917-48918	CD	denotes	8
T25046	48918-48919	-RRB-	denotes	)
T25047	48919-48920	.	denotes	.
T25048	48920-49086	sentence	denotes	Formally, we cannot exclude the possibility that deleting E2f3b might also rescue SAC differentiation, but definitive proof will require analysis of E2f3b null mice.
T25049	48921-48929	RB	denotes	Formally
T25050	48941-48948	VB	denotes	exclude
T25051	48929-48931	,	denotes	,
T25052	48931-48933	PRP	denotes	we
T25053	48934-48937	MD	denotes	can
T25054	48937-48940	RB	denotes	not
T25055	48949-48952	DT	denotes	the
T25056	48953-48964	NN	denotes	possibility
T25057	48965-48969	IN	denotes	that
T25058	48996-49002	VB	denotes	rescue
T25059	48970-48978	VBG	denotes	deleting
T25060	48979-48984	NN	denotes	E2f3b
T25061	48985-48990	MD	denotes	might
T25062	48991-48995	RB	denotes	also
T25063	49003-49006	NN	denotes	SAC
T25064	49007-49022	NN	denotes	differentiation
T25065	49022-49024	,	denotes	,
T25066	49024-49027	CC	denotes	but
T25067	49028-49038	JJ	denotes	definitive
T25068	49039-49044	NN	denotes	proof
T25069	49050-49057	VB	denotes	require
T25070	49045-49049	MD	denotes	will
T25071	49058-49066	NN	denotes	analysis
T25072	49067-49069	IN	denotes	of
T25073	49070-49075	NN	denotes	E2f3b
T25074	49076-49080	JJ	denotes	null
T25075	49081-49085	NNS	denotes	mice
T25076	49085-49086	.	denotes	.
T25077	49086-49201	sentence	denotes	Nevertheless, our data prove that Rb definitely regulates SAC differentiation through the activating E2f3 isoform.
T25078	49087-49099	RB	denotes	Nevertheless
T25079	49110-49115	VBP	denotes	prove
T25080	49099-49101	,	denotes	,
T25081	49101-49104	PRP$	denotes	our
T25082	49105-49109	NNS	denotes	data
T25083	49116-49120	IN	denotes	that
T25084	49135-49144	VBZ	denotes	regulates
T25085	49121-49123	NN	denotes	Rb
T25086	49124-49134	RB	denotes	definitely
T25087	49145-49148	NN	denotes	SAC
T25088	49149-49164	NN	denotes	differentiation
T25089	49165-49172	IN	denotes	through
T25090	49173-49176	DT	denotes	the
T25091	49193-49200	NN	denotes	isoform
T25092	49177-49187	VBG	denotes	activating
T25093	49188-49192	NN	denotes	E2f3
T25094	49200-49201	.	denotes	.
T25716	49203-49211	JJ	denotes	Distinct
T25717	49228-49240	NN	denotes	Localization
T25718	49212-49217	NN	denotes	E2f3a
T25719	49218-49221	CC	denotes	and
T25720	49222-49227	NN	denotes	E2f3b
T25721	49240-49329	sentence	denotes	The subcellular location of E2f isoforms has not to our knowledge been addressed before.
T25722	49241-49244	DT	denotes	The
T25723	49257-49265	NN	denotes	location
T25724	49245-49256	JJ	denotes	subcellular
T25725	49312-49321	VBN	denotes	addressed
T25726	49266-49268	IN	denotes	of
T25727	49269-49272	NN	denotes	E2f
T25728	49273-49281	NNS	denotes	isoforms
T25729	49282-49285	VBZ	denotes	has
T25730	49286-49289	RB	denotes	not
T25731	49290-49292	IN	denotes	to
T25732	49293-49296	PRP$	denotes	our
T25733	49297-49306	NN	denotes	knowledge
T25734	49307-49311	VBN	denotes	been
T25735	49322-49328	RB	denotes	before
T25736	49328-49329	.	denotes	.
T25737	49329-49551	sentence	denotes	E2f3a and E2f3b share 110 C-terminal amino acids that encode the NLS, DNA-binding, marked box, transactivation, and Rb-binding domains [16], yet they exhibit different subcellular distribution in developing retinal cells.
T25738	49330-49335	NN	denotes	E2f3a
T25739	49346-49351	VBP	denotes	share
T25740	49336-49339	CC	denotes	and
T25741	49340-49345	NN	denotes	E2f3b
T25742	49352-49355	CD	denotes	110
T25743	49373-49378	NNS	denotes	acids
T25744	49356-49357	NN	denotes	C
T25745	49358-49366	JJ	denotes	terminal
T25746	49357-49358	HYPH	denotes	-
T25747	49367-49372	NN	denotes	amino
T25748	49379-49383	WDT	denotes	that
T25749	49384-49390	VBP	denotes	encode
T25750	49391-49394	DT	denotes	the
T25751	49457-49464	NNS	denotes	domains
T25752	49395-49398	NN	denotes	NLS
T25753	49398-49400	,	denotes	,
T25754	49400-49403	NN	denotes	DNA
T25755	49403-49404	HYPH	denotes	-
T25756	49404-49411	VBG	denotes	binding
T25757	49411-49413	,	denotes	,
T25758	49413-49419	JJ	denotes	marked
T25759	49420-49423	NN	denotes	box
T25760	49423-49425	,	denotes	,
T25761	49425-49440	NN	denotes	transactivation
T25762	49440-49442	,	denotes	,
T25763	49442-49445	CC	denotes	and
T25764	49446-49448	NN	denotes	Rb
T25765	49448-49449	HYPH	denotes	-
T25766	49449-49456	VBG	denotes	binding
T25767	49465-49466	-LRB-	denotes	[
T25768	49466-49468	CD	denotes	16
T25769	49468-49469	-RRB-	denotes	]
T25770	49469-49471	,	denotes	,
T25771	49471-49474	CC	denotes	yet
T25772	49475-49479	PRP	denotes	they
T25773	49480-49487	VBP	denotes	exhibit
T25774	49488-49497	JJ	denotes	different
T25775	49510-49522	NN	denotes	distribution
T25776	49498-49509	JJ	denotes	subcellular
T25777	49523-49525	IN	denotes	in
T25778	49526-49536	VBG	denotes	developing
T25779	49545-49550	NNS	denotes	cells
T25780	49537-49544	JJ	denotes	retinal
T25781	49550-49551	.	denotes	.
T25782	49551-49619	sentence	denotes	E2f3a is both nuclear and cytoplasmic, but E2f3b is always nuclear.
T25783	49552-49557	NN	denotes	E2f3a
T25784	49558-49560	VBZ	denotes	is
T25785	49561-49565	CC	denotes	both
T25786	49566-49573	JJ	denotes	nuclear
T25787	49574-49577	CC	denotes	and
T25788	49578-49589	JJ	denotes	cytoplasmic
T25789	49589-49591	,	denotes	,
T25790	49591-49594	CC	denotes	but
T25791	49595-49600	NN	denotes	E2f3b
T25792	49601-49603	VBZ	denotes	is
T25793	49604-49610	RB	denotes	always
T25794	49611-49618	JJ	denotes	nuclear
T25795	49618-49619	.	denotes	.
T25796	49619-49727	sentence	denotes	The unique 121- and six-residue N-termini of E2f3a and E2f3b, respectively, likely mediate this difference.
T25797	49620-49623	DT	denotes	The
T25798	49654-49661	NNS	denotes	termini
T25799	49624-49630	JJ	denotes	unique
T25800	49631-49634	CD	denotes	121
T25801	49644-49651	NN	denotes	residue
T25802	49634-49635	HYPH	denotes	-
T25803	49636-49639	CC	denotes	and
T25804	49640-49643	CD	denotes	six
T25805	49643-49644	HYPH	denotes	-
T25806	49652-49653	NNS	denotes	N
T25807	49653-49654	HYPH	denotes	-
T25808	49703-49710	VBP	denotes	mediate
T25809	49662-49664	IN	denotes	of
T25810	49665-49670	NN	denotes	E2f3a
T25811	49671-49674	CC	denotes	and
T25812	49675-49680	NN	denotes	E2f3b
T25813	49680-49682	,	denotes	,
T25814	49682-49694	RB	denotes	respectively
T25815	49694-49696	,	denotes	,
T25816	49696-49702	RB	denotes	likely
T25817	49711-49715	DT	denotes	this
T25818	49716-49726	NN	denotes	difference
T25819	49726-49727	.	denotes	.
T25820	49727-49868	sentence	denotes	This region in E2f1, E2f2, and E2f3a binds Ccna2, establishing a negative regulatory loop that deactivates E2fs in mid-late S-phase [64,65].
T25821	49728-49732	DT	denotes	This
T25822	49733-49739	NN	denotes	region
T25823	49765-49770	VBZ	denotes	binds
T25824	49740-49742	IN	denotes	in
T25825	49743-49747	NN	denotes	E2f1
T25826	49747-49749	,	denotes	,
T25827	49749-49753	NN	denotes	E2f2
T25828	49753-49755	,	denotes	,
T25829	49755-49758	CC	denotes	and
T25830	49759-49764	NN	denotes	E2f3a
T25831	49771-49776	NN	denotes	Ccna2
T25832	49776-49778	,	denotes	,
T25833	49778-49790	VBG	denotes	establishing
T25834	49791-49792	DT	denotes	a
T25835	49813-49817	NN	denotes	loop
T25836	49793-49801	JJ	denotes	negative
T25837	49802-49812	JJ	denotes	regulatory
T25838	49818-49822	WDT	denotes	that
T25839	49823-49834	VBZ	denotes	deactivates
T25840	49835-49839	NNS	denotes	E2fs
T25841	49840-49842	IN	denotes	in
T25842	49843-49846	JJ	denotes	mid
T25843	49847-49851	JJ	denotes	late
T25844	49846-49847	SYM	denotes	-
T25845	49854-49859	NN	denotes	phase
T25846	49852-49853	NN	denotes	S
T25847	49853-49854	HYPH	denotes	-
T25848	49860-49861	-LRB-	denotes	[
T25849	49864-49866	CD	denotes	65
T25850	49861-49863	CD	denotes	64
T25851	49863-49864	,	denotes	,
T25852	49866-49867	-RRB-	denotes	]
T25853	49867-49868	.	denotes	.
T25854	49868-50031	sentence	denotes	However, even E2f3b, which lacks this domain, binds and is regulated by Ccna2 [18], so the domain difference may not explain the unique distributions we observed.
T25855	49869-49876	RB	denotes	However
T25856	49915-49920	VBZ	denotes	binds
T25857	49876-49878	,	denotes	,
T25858	49878-49882	RB	denotes	even
T25859	49883-49888	NN	denotes	E2f3b
T25860	49888-49890	,	denotes	,
T25861	49890-49895	WDT	denotes	which
T25862	49896-49901	VBZ	denotes	lacks
T25863	49902-49906	DT	denotes	this
T25864	49907-49913	NN	denotes	domain
T25865	49913-49915	,	denotes	,
T25866	49921-49924	CC	denotes	and
T25867	49925-49927	VBZ	denotes	is
T25868	49928-49937	VBN	denotes	regulated
T25869	49938-49940	IN	denotes	by
T25870	49941-49946	NN	denotes	Ccna2
T25871	49947-49948	-LRB-	denotes	[
T25872	49948-49950	CD	denotes	18
T25873	49950-49951	-RRB-	denotes	]
T25874	49951-49953	,	denotes	,
T25875	49953-49955	IN	denotes	so
T25876	49986-49993	VB	denotes	explain
T25877	49956-49959	DT	denotes	the
T25878	49967-49977	NN	denotes	difference
T25879	49960-49966	NN	denotes	domain
T25880	49978-49981	MD	denotes	may
T25881	49982-49985	RB	denotes	not
T25882	49994-49997	DT	denotes	the
T25883	50005-50018	NNS	denotes	distributions
T25884	49998-50004	JJ	denotes	unique
T25885	50019-50021	PRP	denotes	we
T25886	50022-50030	VBD	denotes	observed
T25887	50030-50031	.	denotes	.
T25888	50031-50196	sentence	denotes	Rb family and Tfdp proteins can also determine E2f localization [20–22], and we found that a portion of both Rb and Tfdp1 proteins are cytoplasmic in retinal cells.
T25889	50032-50034	NN	denotes	Rb
T25890	50035-50041	NN	denotes	family
T25891	50051-50059	NN	denotes	proteins
T25892	50042-50045	CC	denotes	and
T25893	50046-50050	NN	denotes	Tfdp
T25894	50069-50078	VB	denotes	determine
T25895	50060-50063	MD	denotes	can
T25896	50064-50068	RB	denotes	also
T25897	50079-50082	NN	denotes	E2f
T25898	50083-50095	NN	denotes	localization
T25899	50096-50097	-LRB-	denotes	[
T25900	50097-50099	CD	denotes	20
T25901	50099-50100	SYM	denotes	–
T25902	50100-50102	CD	denotes	22
T25903	50102-50103	-RRB-	denotes	]
T25904	50103-50105	,	denotes	,
T25905	50105-50108	CC	denotes	and
T25906	50109-50111	PRP	denotes	we
T25907	50112-50117	VBD	denotes	found
T25908	50118-50122	IN	denotes	that
T25909	50163-50166	VBP	denotes	are
T25910	50123-50124	DT	denotes	a
T25911	50125-50132	NN	denotes	portion
T25912	50133-50135	IN	denotes	of
T25913	50136-50140	CC	denotes	both
T25914	50141-50143	NN	denotes	Rb
T25915	50154-50162	NN	denotes	proteins
T25916	50144-50147	CC	denotes	and
T25917	50148-50153	NN	denotes	Tfdp1
T25918	50167-50178	JJ	denotes	cytoplasmic
T25919	50179-50181	IN	denotes	in
T25920	50182-50189	JJ	denotes	retinal
T25921	50190-50195	NNS	denotes	cells
T25922	50195-50196	.	denotes	.
T25923	50196-50274	sentence	denotes	Indeed, immunostaining revealed that Rb and E2f3 colocalize to SAC processes.
T25924	50197-50203	RB	denotes	Indeed
T25925	50220-50228	VBD	denotes	revealed
T25926	50203-50205	,	denotes	,
T25927	50205-50219	NN	denotes	immunostaining
T25928	50229-50233	IN	denotes	that
T25929	50246-50256	VBP	denotes	colocalize
T25930	50234-50236	NN	denotes	Rb
T25931	50237-50240	CC	denotes	and
T25932	50241-50245	NN	denotes	E2f3
T25933	50257-50259	IN	denotes	to
T25934	50260-50263	NN	denotes	SAC
T25935	50264-50273	NNS	denotes	processes
T25936	50273-50274	.	denotes	.
T25937	50274-50477	sentence	denotes	The nuclear localization of E2f3b contrasts with that of other repressive E2fs in differentiating muscle, where E2f5 switches from the nucleus to cytoplasm, while E2f4 remains in both compartments [23].
T25938	50275-50278	DT	denotes	The
T25939	50287-50299	NN	denotes	localization
T25940	50279-50286	JJ	denotes	nuclear
T25941	50309-50318	VBZ	denotes	contrasts
T25942	50300-50302	IN	denotes	of
T25943	50303-50308	NN	denotes	E2f3b
T25944	50319-50323	IN	denotes	with
T25945	50324-50328	DT	denotes	that
T25946	50329-50331	IN	denotes	of
T25947	50332-50337	JJ	denotes	other
T25948	50349-50353	NNS	denotes	E2fs
T25949	50338-50348	JJ	denotes	repressive
T25950	50354-50356	IN	denotes	in
T25951	50357-50372	VBG	denotes	differentiating
T25952	50373-50379	NN	denotes	muscle
T25953	50379-50381	,	denotes	,
T25954	50381-50386	WRB	denotes	where
T25955	50392-50400	VBZ	denotes	switches
T25956	50387-50391	NN	denotes	E2f5
T25957	50401-50405	IN	denotes	from
T25958	50406-50409	DT	denotes	the
T25959	50410-50417	NN	denotes	nucleus
T25960	50418-50420	IN	denotes	to
T25961	50421-50430	NN	denotes	cytoplasm
T25962	50430-50432	,	denotes	,
T25963	50432-50437	IN	denotes	while
T25964	50443-50450	VBZ	denotes	remains
T25965	50438-50442	NN	denotes	E2f4
T25966	50451-50453	IN	denotes	in
T25967	50454-50458	DT	denotes	both
T25968	50459-50471	NNS	denotes	compartments
T25969	50472-50473	-LRB-	denotes	[
T25970	50473-50475	CD	denotes	23
T25971	50475-50476	-RRB-	denotes	]
T25972	50476-50477	.	denotes	.
T25973	50477-50602	sentence	denotes	The distinct compartmentalization of E2f3a and E2f3b in the retina suggests temporally and functionally distinct activities.
T25974	50478-50481	DT	denotes	The
T25975	50491-50511	NN	denotes	compartmentalization
T25976	50482-50490	JJ	denotes	distinct
T25977	50545-50553	VBZ	denotes	suggests
T25978	50512-50514	IN	denotes	of
T25979	50515-50520	NN	denotes	E2f3a
T25980	50521-50524	CC	denotes	and
T25981	50525-50530	NN	denotes	E2f3b
T25982	50531-50533	IN	denotes	in
T25983	50534-50537	DT	denotes	the
T25984	50538-50544	NN	denotes	retina
T25985	50554-50564	RB	denotes	temporally
T25986	50582-50590	JJ	denotes	distinct
T25987	50565-50568	CC	denotes	and
T25988	50569-50581	RB	denotes	functionally
T25989	50591-50601	NNS	denotes	activities
T25990	50601-50602	.	denotes	.
T25991	50602-50724	sentence	denotes	Rb distribution matches that of E2f3a, consistent with its critical role in supporting SAC differentiation through E2f3a.
T25992	50603-50605	NN	denotes	Rb
T25993	50606-50618	NN	denotes	distribution
T25994	50619-50626	VBZ	denotes	matches
T25995	50627-50631	DT	denotes	that
T25996	50632-50634	IN	denotes	of
T25997	50635-50640	NN	denotes	E2f3a
T25998	50640-50642	,	denotes	,
T25999	50642-50652	JJ	denotes	consistent
T26000	50653-50657	IN	denotes	with
T26001	50658-50661	PRP$	denotes	its
T26002	50671-50675	NN	denotes	role
T26003	50662-50670	JJ	denotes	critical
T26004	50676-50678	IN	denotes	in
T26005	50679-50689	VBG	denotes	supporting
T26006	50690-50693	NN	denotes	SAC
T26007	50694-50709	NN	denotes	differentiation
T26008	50710-50717	IN	denotes	through
T26009	50718-50723	NN	denotes	E2f3a
T26010	50723-50724	.	denotes	.
T29767	55472-55475	CC	denotes	and
T26609	50726-50733	JJ	denotes	Ectopic
T26610	50734-50742	NN	denotes	Division
T26611	50743-50746	CC	denotes	and
T26612	50747-50762	NN	denotes	Differentiation
T26613	50762-50945	sentence	denotes	Rb is critical to ensure that many types of terminally differentiating cells leave the cell cycle (e.g., neurons, gut and skin epithelia, muscle, and lens fibres) (reviewed in [66]).
T26614	50763-50765	NN	denotes	Rb
T26615	50766-50768	VBZ	denotes	is
T26616	50769-50777	JJ	denotes	critical
T26617	50778-50780	TO	denotes	to
T26618	50781-50787	VB	denotes	ensure
T26619	50788-50792	IN	denotes	that
T26620	50840-50845	VBP	denotes	leave
T26621	50793-50797	JJ	denotes	many
T26622	50798-50803	NNS	denotes	types
T26623	50804-50806	IN	denotes	of
T26624	50807-50817	RB	denotes	terminally
T26625	50818-50833	VBG	denotes	differentiating
T26626	50834-50839	NNS	denotes	cells
T26627	50846-50849	DT	denotes	the
T26628	50855-50860	NN	denotes	cycle
T26629	50850-50854	NN	denotes	cell
T26630	50861-50862	-LRB-	denotes	(
T26631	50862-50866	FW	denotes	e.g.
T26632	50868-50875	NNS	denotes	neurons
T26633	50866-50868	,	denotes	,
T26634	50875-50877	,	denotes	,
T26635	50877-50880	NN	denotes	gut
T26636	50890-50899	NNS	denotes	epithelia
T26637	50881-50884	CC	denotes	and
T26638	50885-50889	NN	denotes	skin
T26639	50899-50901	,	denotes	,
T26640	50901-50907	NN	denotes	muscle
T26641	50907-50909	,	denotes	,
T26642	50909-50912	CC	denotes	and
T26643	50913-50917	NN	denotes	lens
T26644	50918-50924	NNS	denotes	fibres
T26645	50924-50925	-RRB-	denotes	)
T26646	50926-50927	-LRB-	denotes	(
T26647	50927-50935	VBN	denotes	reviewed
T26648	50936-50938	IN	denotes	in
T26649	50939-50940	-LRB-	denotes	[
T26650	50940-50942	CD	denotes	66
T26651	50942-50943	-RRB-	denotes	]
T26652	50943-50944	-RRB-	denotes	)
T26653	50944-50945	.	denotes	.
T26654	50945-51147	sentence	denotes	Early overexpression studies in vitro suggested Rb might temper expansion of cycling cells, but KO studies in vivo indicate that its major role is to block division in terminally differentiating cells.
T26655	50946-50951	JJ	denotes	Early
T26656	50967-50974	NNS	denotes	studies
T26657	50952-50966	NN	denotes	overexpression
T26658	50984-50993	VBN	denotes	suggested
T26659	50975-50977	FW	denotes	in
T26660	50978-50983	FW	denotes	vitro
T26661	50994-50996	NN	denotes	Rb
T26662	51003-51009	VB	denotes	temper
T26663	50997-51002	MD	denotes	might
T26664	51010-51019	NN	denotes	expansion
T26665	51020-51022	IN	denotes	of
T26666	51023-51030	NN	denotes	cycling
T26667	51031-51036	NNS	denotes	cells
T26668	51036-51038	,	denotes	,
T26669	51038-51041	CC	denotes	but
T26670	51042-51044	NN	denotes	KO
T26671	51045-51052	NNS	denotes	studies
T26672	51061-51069	VBP	denotes	indicate
T26673	51053-51055	FW	denotes	in
T26674	51056-51060	FW	denotes	vivo
T26675	51070-51074	IN	denotes	that
T26676	51090-51092	VBZ	denotes	is
T26677	51075-51078	PRP$	denotes	its
T26678	51085-51089	NN	denotes	role
T26679	51079-51084	JJ	denotes	major
T26680	51093-51095	TO	denotes	to
T26681	51096-51101	VB	denotes	block
T26682	51102-51110	NN	denotes	division
T26683	51111-51113	IN	denotes	in
T26684	51114-51124	RB	denotes	terminally
T26685	51125-51140	VBG	denotes	differentiating
T26686	51141-51146	NNS	denotes	cells
T26687	51146-51147	.	denotes	.
T26688	51147-51250	sentence	denotes	In its absence, many (but clearly not all) aspects of differentiation go ahead relatively unperturbed.
T26689	51148-51150	IN	denotes	In
T26690	51218-51220	VBP	denotes	go
T26691	51151-51154	PRP$	denotes	its
T26692	51155-51162	NN	denotes	absence
T26693	51162-51164	,	denotes	,
T26694	51164-51168	JJ	denotes	many
T26695	51169-51170	-LRB-	denotes	(
T26696	51170-51173	CC	denotes	but
T26697	51174-51181	RB	denotes	clearly
T26698	51182-51185	RB	denotes	not
T26699	51186-51189	DT	denotes	all
T26700	51191-51198	NNS	denotes	aspects
T26701	51189-51190	-RRB-	denotes	)
T26702	51199-51201	IN	denotes	of
T26703	51202-51217	NN	denotes	differentiation
T26704	51221-51226	RP	denotes	ahead
T26705	51227-51237	RB	denotes	relatively
T26706	51238-51249	JJ	denotes	unperturbed
T26707	51249-51250	.	denotes	.
T26708	51250-51412	sentence	denotes	In the retina, differentiating transition cells are born in the absence of Rb, migrate to the correct layer, and express appropriate markers ([2] and this work).
T26709	51251-51253	IN	denotes	In
T26710	51303-51307	VBN	denotes	born
T26711	51254-51257	DT	denotes	the
T26712	51258-51264	NN	denotes	retina
T26713	51264-51266	,	denotes	,
T26714	51266-51281	VBG	denotes	differentiating
T26715	51293-51298	NNS	denotes	cells
T26716	51282-51292	NN	denotes	transition
T26717	51299-51302	VBP	denotes	are
T26718	51308-51310	IN	denotes	in
T26719	51311-51314	DT	denotes	the
T26720	51315-51322	NN	denotes	absence
T26721	51323-51325	IN	denotes	of
T26722	51326-51328	NN	denotes	Rb
T26723	51328-51330	,	denotes	,
T26724	51330-51337	VBP	denotes	migrate
T26725	51338-51340	IN	denotes	to
T26726	51341-51344	DT	denotes	the
T26727	51353-51358	NN	denotes	layer
T26728	51345-51352	JJ	denotes	correct
T26729	51358-51360	,	denotes	,
T26730	51360-51363	CC	denotes	and
T26731	51364-51371	VBP	denotes	express
T26732	51372-51383	JJ	denotes	appropriate
T26733	51384-51391	NNS	denotes	markers
T26734	51392-51393	-LRB-	denotes	(
T26735	51394-51395	CD	denotes	2
T26736	51393-51394	-LRB-	denotes	[
T26737	51395-51396	-RRB-	denotes	]
T26738	51397-51400	CC	denotes	and
T26739	51401-51405	DT	denotes	this
T26740	51406-51410	NN	denotes	work
T26741	51410-51411	-RRB-	denotes	)
T26742	51411-51412	.	denotes	.
T26743	51412-51697	sentence	denotes	In brain, Rb KO neurons migrate away from the ventricular zone and switch on Tubb3 (βIII-tubulin), but continue to incorporate BrdU [13], and in gut epithelia, differentiated enterocytes migrate up the villi and activate expression of serotonin, yet continue to incorporate BrdU [67].
T26744	51413-51415	IN	denotes	In
T26745	51437-51444	VBP	denotes	migrate
T26746	51416-51421	NN	denotes	brain
T26747	51421-51423	,	denotes	,
T26748	51423-51425	NN	denotes	Rb
T26749	51426-51428	NN	denotes	KO
T26750	51429-51436	NNS	denotes	neurons
T26751	51445-51449	RB	denotes	away
T26752	51450-51454	IN	denotes	from
T26753	51455-51458	DT	denotes	the
T26754	51471-51475	NN	denotes	zone
T26755	51459-51470	JJ	denotes	ventricular
T26756	51476-51479	CC	denotes	and
T26757	51480-51486	VBP	denotes	switch
T26758	51487-51489	RP	denotes	on
T26759	51490-51495	NN	denotes	Tubb3
T26760	51496-51497	-LRB-	denotes	(
T26761	51497-51501	NN	denotes	βIII
T26762	51502-51509	NN	denotes	tubulin
T26763	51501-51502	HYPH	denotes	-
T26764	51509-51510	-RRB-	denotes	)
T26765	51510-51512	,	denotes	,
T26766	51512-51515	CC	denotes	but
T26767	51516-51524	VBP	denotes	continue
T26768	51525-51527	TO	denotes	to
T26769	51528-51539	VB	denotes	incorporate
T26770	51540-51544	NN	denotes	BrdU
T26771	51545-51546	-LRB-	denotes	[
T26772	51546-51548	CD	denotes	13
T26773	51548-51549	-RRB-	denotes	]
T26774	51549-51551	,	denotes	,
T26775	51551-51554	CC	denotes	and
T26776	51555-51557	IN	denotes	in
T26777	51600-51607	VBP	denotes	migrate
T26778	51558-51561	NN	denotes	gut
T26779	51562-51571	NNS	denotes	epithelia
T26780	51571-51573	,	denotes	,
T26781	51573-51587	VBN	denotes	differentiated
T26782	51588-51599	NNS	denotes	enterocytes
T26783	51608-51610	IN	denotes	up
T26784	51611-51614	DT	denotes	the
T26785	51615-51620	NNS	denotes	villi
T26786	51621-51624	CC	denotes	and
T26787	51625-51633	VBP	denotes	activate
T26788	51634-51644	NN	denotes	expression
T26789	51645-51647	IN	denotes	of
T26790	51648-51657	NN	denotes	serotonin
T26791	51657-51659	,	denotes	,
T26792	51659-51662	CC	denotes	yet
T26793	51663-51671	VBP	denotes	continue
T26794	51672-51674	TO	denotes	to
T26795	51675-51686	VB	denotes	incorporate
T26796	51687-51691	NN	denotes	BrdU
T26797	51692-51693	-LRB-	denotes	[
T26798	51693-51695	CD	denotes	67
T26799	51695-51696	-RRB-	denotes	]
T26800	51696-51697	.	denotes	.
T26801	51697-51924	sentence	denotes	In the case of SACs, the differentiation defects we observed (e.g., loss of Slc18a3 and Chat) were not due to aberrant division, but it is possible there are other problems with these cells that are caused by ectopic division.
T26802	51698-51700	IN	denotes	In
T26803	51792-51796	VBD	denotes	were
T26804	51701-51704	DT	denotes	the
T26805	51705-51709	NN	denotes	case
T26806	51710-51712	IN	denotes	of
T26807	51713-51717	NNS	denotes	SACs
T26808	51717-51719	,	denotes	,
T26809	51719-51722	DT	denotes	the
T26810	51723-51738	NN	denotes	differentiation
T26811	51739-51746	VBZ	denotes	defects
T26812	51747-51749	PRP	denotes	we
T26813	51750-51758	VBD	denotes	observed
T26814	51759-51760	-LRB-	denotes	(
T26815	51760-51764	FW	denotes	e.g.
T26816	51766-51770	NN	denotes	loss
T26817	51764-51766	,	denotes	,
T26818	51771-51773	IN	denotes	of
T26819	51774-51781	NN	denotes	Slc18a3
T26820	51782-51785	CC	denotes	and
T26821	51786-51790	NN	denotes	Chat
T26822	51790-51791	-RRB-	denotes	)
T26823	51797-51800	RB	denotes	not
T26824	51801-51804	IN	denotes	due
T26825	51805-51807	IN	denotes	to
T26826	51808-51816	JJ	denotes	aberrant
T26827	51817-51825	NN	denotes	division
T26828	51825-51827	,	denotes	,
T26829	51827-51830	CC	denotes	but
T26830	51831-51833	PRP	denotes	it
T26831	51834-51836	VBZ	denotes	is
T26832	51837-51845	JJ	denotes	possible
T26833	51846-51851	EX	denotes	there
T26834	51852-51855	VBP	denotes	are
T26835	51856-51861	JJ	denotes	other
T26836	51862-51870	NNS	denotes	problems
T26837	51871-51875	IN	denotes	with
T26838	51876-51881	DT	denotes	these
T26839	51882-51887	NNS	denotes	cells
T26840	51888-51892	WDT	denotes	that
T26841	51897-51903	VBN	denotes	caused
T26842	51893-51896	VBP	denotes	are
T26843	51904-51906	IN	denotes	by
T26844	51907-51914	JJ	denotes	ectopic
T26845	51915-51923	NN	denotes	division
T26846	51923-51924	.	denotes	.
T26847	51924-52048	sentence	denotes	Nevertheless, it is clear that many aspects of differentiation in multiple cell types are compatible with ectopic division.
T26848	51925-51937	RB	denotes	Nevertheless
T26849	51942-51944	VBZ	denotes	is
T26850	51937-51939	,	denotes	,
T26851	51939-51941	PRP	denotes	it
T26852	51945-51950	JJ	denotes	clear
T26853	51951-51955	IN	denotes	that
T26854	52011-52014	VBP	denotes	are
T26855	51956-51960	JJ	denotes	many
T26856	51961-51968	NNS	denotes	aspects
T26857	51969-51971	IN	denotes	of
T26858	51972-51987	NN	denotes	differentiation
T26859	51988-51990	IN	denotes	in
T26860	51991-51999	JJ	denotes	multiple
T26861	52005-52010	NNS	denotes	types
T26862	52000-52004	NN	denotes	cell
T26863	52015-52025	JJ	denotes	compatible
T26864	52026-52030	IN	denotes	with
T26865	52031-52038	JJ	denotes	ectopic
T26866	52039-52047	NN	denotes	division
T26867	52047-52048	.	denotes	.
T26868	52048-52209	sentence	denotes	However, division of terminally differentiating cells is dangerous, since it may facilitate transformation, as is the case in retinoblastoma (reviewed in [66]).
T26869	52049-52056	RB	denotes	However
T26870	52103-52105	VBZ	denotes	is
T26871	52056-52058	,	denotes	,
T26872	52058-52066	NN	denotes	division
T26873	52067-52069	IN	denotes	of
T26874	52070-52080	RB	denotes	terminally
T26875	52081-52096	VBG	denotes	differentiating
T26876	52097-52102	NNS	denotes	cells
T26877	52106-52115	JJ	denotes	dangerous
T26878	52115-52117	,	denotes	,
T26879	52117-52122	IN	denotes	since
T26880	52130-52140	VB	denotes	facilitate
T26881	52123-52125	PRP	denotes	it
T26882	52126-52129	MD	denotes	may
T26883	52141-52155	NN	denotes	transformation
T26884	52155-52157	,	denotes	,
T26885	52157-52159	IN	denotes	as
T26886	52160-52162	VBZ	denotes	is
T26887	52163-52166	DT	denotes	the
T26888	52167-52171	NN	denotes	case
T26889	52172-52174	IN	denotes	in
T26890	52175-52189	NN	denotes	retinoblastoma
T26891	52190-52191	-LRB-	denotes	(
T26892	52191-52199	VBN	denotes	reviewed
T26893	52200-52202	IN	denotes	in
T26894	52203-52204	-LRB-	denotes	[
T26895	52204-52206	CD	denotes	66
T26896	52206-52207	-RRB-	denotes	]
T26897	52207-52208	-RRB-	denotes	)
T26898	52208-52209	.	denotes	.
T29768	55476-55478	NN	denotes	Rb
T27309	52728-52734	IN	denotes	during
T27310	52735-52747	NN	denotes	neurogenesis
T27218	52211-52214	WRB	denotes	How
T27219	52226-52233	VB	denotes	Perturb
T27220	52215-52219	VBZ	denotes	Does
T27221	52220-52225	NN	denotes	E2f3a
T27222	52234-52237	NN	denotes	SAC
T27223	52238-52253	NN	denotes	Differentiation
T27224	52253-52254	.	denotes	?
T27225	52254-52472	sentence	denotes	E2f3a could disrupt SAC differentiation through its well known role as a transcriptional activator, or, in view of the discovery that it is partially cytoplasmic, E2f3a may affect processes other than gene regulation.
T27226	52255-52260	NN	denotes	E2f3a
T27227	52267-52274	VB	denotes	disrupt
T27228	52261-52266	MD	denotes	could
T27229	52275-52278	NN	denotes	SAC
T27230	52279-52294	NN	denotes	differentiation
T27231	52295-52302	IN	denotes	through
T27232	52303-52306	PRP$	denotes	its
T27233	52318-52322	NN	denotes	role
T27234	52307-52311	RB	denotes	well
T27235	52312-52317	VBN	denotes	known
T27236	52323-52325	IN	denotes	as
T27237	52326-52327	DT	denotes	a
T27238	52344-52353	NN	denotes	activator
T27239	52328-52343	JJ	denotes	transcriptional
T27240	52353-52355	,	denotes	,
T27241	52355-52357	CC	denotes	or
T27242	52357-52359	,	denotes	,
T27243	52359-52361	IN	denotes	in
T27244	52428-52434	VB	denotes	affect
T27245	52362-52366	NN	denotes	view
T27246	52367-52369	IN	denotes	of
T27247	52370-52373	DT	denotes	the
T27248	52374-52383	NN	denotes	discovery
T27249	52384-52388	IN	denotes	that
T27250	52392-52394	VBZ	denotes	is
T27251	52389-52391	PRP	denotes	it
T27252	52395-52404	RB	denotes	partially
T27253	52405-52416	JJ	denotes	cytoplasmic
T27254	52416-52418	,	denotes	,
T27255	52418-52423	NN	denotes	E2f3a
T27256	52424-52427	MD	denotes	may
T27257	52435-52444	NNS	denotes	processes
T27258	52445-52450	JJ	denotes	other
T27259	52451-52455	IN	denotes	than
T27260	52456-52460	NN	denotes	gene
T27261	52461-52471	NN	denotes	regulation
T27262	52471-52472	.	denotes	.
T27263	52472-52662	sentence	denotes	Both scenarios are feasible since E2fs regulate differentiation genes [44–48], and cell cycle regulators, such as Cdkn1b, have cytoplasmic activities that influence differentiation [68,69].
T27264	52473-52477	DT	denotes	Both
T27265	52478-52487	NNS	denotes	scenarios
T27266	52488-52491	VBP	denotes	are
T27267	52492-52500	JJ	denotes	feasible
T27268	52501-52506	IN	denotes	since
T27269	52512-52520	VBP	denotes	regulate
T27270	52507-52511	NNS	denotes	E2fs
T27271	52521-52536	NN	denotes	differentiation
T27272	52537-52542	NNS	denotes	genes
T27273	52543-52544	-LRB-	denotes	[
T27274	52544-52546	CD	denotes	44
T27275	52546-52547	SYM	denotes	–
T27276	52547-52549	CD	denotes	48
T27277	52549-52550	-RRB-	denotes	]
T27278	52550-52552	,	denotes	,
T27279	52552-52555	CC	denotes	and
T27280	52556-52560	NN	denotes	cell
T27281	52561-52566	NN	denotes	cycle
T27282	52567-52577	NNS	denotes	regulators
T27283	52595-52599	VBP	denotes	have
T27284	52577-52579	,	denotes	,
T27285	52579-52583	JJ	denotes	such
T27286	52584-52586	IN	denotes	as
T27287	52587-52593	NN	denotes	Cdkn1b
T27288	52593-52595	,	denotes	,
T27289	52600-52611	JJ	denotes	cytoplasmic
T27290	52612-52622	NNS	denotes	activities
T27291	52623-52627	WDT	denotes	that
T27292	52628-52637	VBP	denotes	influence
T27293	52638-52653	NN	denotes	differentiation
T27294	52654-52655	-LRB-	denotes	[
T27295	52658-52660	CD	denotes	69
T27296	52655-52657	CD	denotes	68
T27297	52657-52658	,	denotes	,
T27298	52660-52661	-RRB-	denotes	]
T27299	52661-52662	.	denotes	.
T27300	52662-52784	sentence	denotes	Many transcription factors shuttle between nucleus and cytoplasm during neurogenesis (e.g., [70] and references therein).
T27301	52663-52667	JJ	denotes	Many
T27302	52682-52689	NNS	denotes	factors
T27303	52668-52681	NN	denotes	transcription
T27304	52690-52697	VBP	denotes	shuttle
T27305	52698-52705	IN	denotes	between
T27306	52706-52713	NN	denotes	nucleus
T27307	52714-52717	CC	denotes	and
T27308	52718-52727	NN	denotes	cytoplasm
T27311	52748-52749	-LRB-	denotes	(
T27312	52756-52758	CD	denotes	70
T27313	52749-52753	FW	denotes	e.g.
T27314	52753-52755	,	denotes	,
T27315	52755-52756	-LRB-	denotes	[
T27316	52758-52759	-RRB-	denotes	]
T27317	52760-52763	CC	denotes	and
T27318	52764-52774	NNS	denotes	references
T27319	52775-52782	RB	denotes	therein
T27320	52782-52783	-RRB-	denotes	)
T27321	52783-52784	.	denotes	.
T27322	52784-52986	sentence	denotes	It may be difficult to identify E2f3a-specific target genes or cytoplasmic proteins in SACs since these neurons are a small proportion (<1%) of the total retina and only ~5.2% of amacrine neurons [38].
T27323	52785-52787	PRP	denotes	It
T27324	52792-52794	VB	denotes	be
T27325	52788-52791	MD	denotes	may
T27326	52795-52804	JJ	denotes	difficult
T27327	52805-52807	TO	denotes	to
T27328	52808-52816	VB	denotes	identify
T27329	52817-52822	NN	denotes	E2f3a
T27330	52823-52831	JJ	denotes	specific
T27331	52822-52823	HYPH	denotes	-
T27332	52839-52844	NNS	denotes	genes
T27333	52832-52838	NN	denotes	target
T27334	52845-52847	CC	denotes	or
T27335	52848-52859	JJ	denotes	cytoplasmic
T27336	52860-52868	NN	denotes	proteins
T27337	52869-52871	IN	denotes	in
T27338	52872-52876	NNS	denotes	SACs
T27339	52877-52882	IN	denotes	since
T27340	52897-52900	VBP	denotes	are
T27341	52883-52888	DT	denotes	these
T27342	52889-52896	NNS	denotes	neurons
T27343	52901-52902	DT	denotes	a
T27344	52909-52919	NN	denotes	proportion
T27345	52903-52908	JJ	denotes	small
T27346	52920-52921	-LRB-	denotes	(
T27347	52921-52922	SYM	denotes	<
T27348	52922-52923	CD	denotes	1
T27349	52923-52924	NN	denotes	%
T27350	52924-52925	-RRB-	denotes	)
T27351	52926-52928	IN	denotes	of
T27352	52929-52932	DT	denotes	the
T27353	52939-52945	NN	denotes	retina
T27354	52933-52938	JJ	denotes	total
T27355	52946-52949	CC	denotes	and
T27356	52950-52954	RB	denotes	only
T27357	52956-52959	CD	denotes	5.2
T27358	52955-52956	SYM	denotes	~
T27359	52959-52960	NN	denotes	%
T27360	52961-52963	IN	denotes	of
T27361	52964-52972	JJ	denotes	amacrine
T27362	52973-52980	NNS	denotes	neurons
T27363	52981-52982	-LRB-	denotes	[
T27364	52982-52984	CD	denotes	38
T27365	52984-52985	-RRB-	denotes	]
T27366	52985-52986	.	denotes	.
T27799	53008-53010	NN	denotes	Rb
T27800	53020-53021	.	denotes	?
T27794	52988-52990	VBP	denotes	Do
T27795	52996-53003	VB	denotes	Mediate
T27796	52991-52995	NNS	denotes	E2fs
T27797	53004-53007	DT	denotes	All
T27798	53011-53020	NNS	denotes	Functions
T27801	53021-53137	sentence	denotes	Others have suggested that Rb promotes differentiation in non-neuronal cells through E2f-independent means [31–33].
T27802	53022-53028	NNS	denotes	Others
T27803	53034-53043	VBN	denotes	suggested
T27804	53029-53033	VBP	denotes	have
T27805	53044-53048	IN	denotes	that
T27806	53052-53060	VBZ	denotes	promotes
T27807	53049-53051	NN	denotes	Rb
T27808	53061-53076	NN	denotes	differentiation
T27809	53077-53079	IN	denotes	in
T27810	53080-53092	JJ	denotes	non-neuronal
T27811	53093-53098	NNS	denotes	cells
T27812	53099-53106	IN	denotes	through
T27813	53107-53110	NN	denotes	E2f
T27814	53111-53122	JJ	denotes	independent
T27815	53110-53111	HYPH	denotes	-
T27816	53123-53128	NNS	denotes	means
T27817	53129-53130	-LRB-	denotes	[
T27818	53130-53132	CD	denotes	31
T27819	53132-53133	SYM	denotes	–
T27820	53133-53135	CD	denotes	33
T27821	53135-53136	-RRB-	denotes	]
T27822	53136-53137	.	denotes	.
T27823	53137-53283	sentence	denotes	However, these studies did not assess whether these cell types differentiate normally if Rb is deleted along with one or more E2f family members.
T27824	53138-53145	RB	denotes	However
T27825	53169-53175	VB	denotes	assess
T27826	53145-53147	,	denotes	,
T27827	53147-53152	DT	denotes	these
T27828	53153-53160	NNS	denotes	studies
T27829	53161-53164	VBD	denotes	did
T27830	53165-53168	RB	denotes	not
T27831	53176-53183	IN	denotes	whether
T27832	53201-53214	VBP	denotes	differentiate
T27833	53184-53189	DT	denotes	these
T27834	53195-53200	NNS	denotes	types
T27835	53190-53194	NN	denotes	cell
T27836	53215-53223	RB	denotes	normally
T27837	53224-53226	IN	denotes	if
T27838	53233-53240	VBN	denotes	deleted
T27839	53227-53229	NN	denotes	Rb
T27840	53230-53232	VBZ	denotes	is
T27841	53241-53246	IN	denotes	along
T27842	53247-53251	IN	denotes	with
T27843	53252-53255	CD	denotes	one
T27844	53275-53282	NNS	denotes	members
T27845	53256-53258	CC	denotes	or
T27846	53259-53263	JJR	denotes	more
T27847	53264-53267	NN	denotes	E2f
T27848	53268-53274	NN	denotes	family
T27849	53282-53283	.	denotes	.
T27850	53283-53374	sentence	denotes	One study reported that Rb mutants that do not bind E2f still induce differentiation [30].
T27851	53284-53287	CD	denotes	One
T27852	53288-53293	NN	denotes	study
T27853	53294-53302	VBD	denotes	reported
T27854	53303-53307	IN	denotes	that
T27855	53346-53352	VBP	denotes	induce
T27856	53308-53310	NN	denotes	Rb
T27857	53311-53318	NNS	denotes	mutants
T27858	53319-53323	WDT	denotes	that
T27859	53331-53335	VB	denotes	bind
T27860	53324-53326	VBP	denotes	do
T27861	53327-53330	RB	denotes	not
T27862	53336-53339	NN	denotes	E2f
T27863	53340-53345	RB	denotes	still
T27864	53353-53368	NN	denotes	differentiation
T27865	53369-53370	-LRB-	denotes	[
T27866	53370-53372	CD	denotes	30
T27867	53372-53373	-RRB-	denotes	]
T27868	53373-53374	.	denotes	.
T27869	53374-53556	sentence	denotes	However, the binding assays were performed in solution, and we have found that several of these mutants do bind E2f, albeit weakly, on chromatin (T. Yu and R. B., unpublished data).
T27870	53375-53382	RB	denotes	However
T27871	53408-53417	VBN	denotes	performed
T27872	53382-53384	,	denotes	,
T27873	53384-53387	DT	denotes	the
T27874	53396-53402	NNS	denotes	assays
T27875	53388-53395	NN	denotes	binding
T27876	53403-53407	VBD	denotes	were
T27877	53418-53420	IN	denotes	in
T27878	53421-53429	NN	denotes	solution
T27879	53429-53431	,	denotes	,
T27880	53431-53434	CC	denotes	and
T27881	53435-53437	PRP	denotes	we
T27882	53443-53448	VBN	denotes	found
T27883	53438-53442	VBP	denotes	have
T27884	53449-53453	IN	denotes	that
T27885	53482-53486	VB	denotes	bind
T27886	53454-53461	JJ	denotes	several
T27887	53462-53464	IN	denotes	of
T27888	53465-53470	DT	denotes	these
T27889	53471-53478	NNS	denotes	mutants
T27890	53479-53481	VBP	denotes	do
T27891	53487-53490	NN	denotes	E2f
T27892	53490-53492	,	denotes	,
T27893	53492-53498	IN	denotes	albeit
T27894	53499-53505	RB	denotes	weakly
T27895	53505-53507	,	denotes	,
T27896	53507-53509	IN	denotes	on
T27897	53510-53519	NN	denotes	chromatin
T27898	53520-53521	-LRB-	denotes	(
T27899	53521-53523	NNP	denotes	T.
T27900	53524-53526	NNP	denotes	Yu
T27901	53527-53530	CC	denotes	and
T27902	53531-53533	NNP	denotes	R.
T27903	53534-53536	NNP	denotes	B.
T27904	53536-53538	,	denotes	,
T27905	53538-53549	JJ	denotes	unpublished
T27906	53550-53554	NNS	denotes	data
T27907	53554-53555	-RRB-	denotes	)
T27908	53555-53556	.	denotes	.
T27909	53556-53754	sentence	denotes	It is possible that Rb-mediated potentiation of tissue-specific transcription factors may, at least in some cases, be a redundant activity, and that the only critical Rb function is to inhibit E2f.
T27910	53557-53559	PRP	denotes	It
T27911	53560-53562	VBZ	denotes	is
T27912	53563-53571	JJ	denotes	possible
T27913	53572-53576	IN	denotes	that
T27914	53672-53674	VB	denotes	be
T27915	53577-53579	NN	denotes	Rb
T27916	53580-53588	VBN	denotes	mediated
T27917	53579-53580	HYPH	denotes	-
T27918	53589-53601	NN	denotes	potentiation
T27919	53602-53604	IN	denotes	of
T27920	53605-53611	NN	denotes	tissue
T27921	53612-53620	JJ	denotes	specific
T27922	53611-53612	HYPH	denotes	-
T27923	53635-53642	NNS	denotes	factors
T27924	53621-53634	NN	denotes	transcription
T27925	53643-53646	MD	denotes	may
T27926	53646-53648	,	denotes	,
T27927	53648-53650	RB	denotes	at
T27928	53651-53656	RBS	denotes	least
T27929	53657-53659	IN	denotes	in
T27930	53660-53664	DT	denotes	some
T27931	53665-53670	NNS	denotes	cases
T27932	53670-53672	,	denotes	,
T27933	53675-53676	DT	denotes	a
T27934	53687-53695	NN	denotes	activity
T27935	53677-53686	JJ	denotes	redundant
T27936	53695-53697	,	denotes	,
T27937	53697-53700	CC	denotes	and
T27938	53701-53705	IN	denotes	that
T27939	53736-53738	VBZ	denotes	is
T27940	53706-53709	DT	denotes	the
T27941	53727-53735	NN	denotes	function
T27942	53710-53714	JJ	denotes	only
T27943	53715-53723	JJ	denotes	critical
T27944	53724-53726	NN	denotes	Rb
T27945	53739-53741	TO	denotes	to
T27946	53742-53749	VB	denotes	inhibit
T27947	53750-53753	NN	denotes	E2f
T27948	53753-53754	.	denotes	.
T27949	53754-53892	sentence	denotes	Our study is the first to our knowledge to assess comprehensively whether Rb KO cells can differentiate in the absence of different E2fs.
T27950	53755-53758	PRP$	denotes	Our
T27951	53759-53764	NN	denotes	study
T27952	53765-53767	VBZ	denotes	is
T27953	53768-53771	DT	denotes	the
T27954	53772-53777	JJ	denotes	first
T27955	53778-53780	IN	denotes	to
T27956	53781-53784	PRP$	denotes	our
T27957	53785-53794	NN	denotes	knowledge
T27958	53795-53797	TO	denotes	to
T27959	53798-53804	VB	denotes	assess
T27960	53805-53820	RB	denotes	comprehensively
T27961	53821-53828	IN	denotes	whether
T27962	53845-53858	VB	denotes	differentiate
T27963	53829-53831	NN	denotes	Rb
T27964	53832-53834	NN	denotes	KO
T27965	53835-53840	NNS	denotes	cells
T27966	53841-53844	MD	denotes	can
T27967	53859-53861	IN	denotes	in
T27968	53862-53865	DT	denotes	the
T27969	53866-53873	NN	denotes	absence
T27970	53874-53876	IN	denotes	of
T27971	53877-53886	JJ	denotes	different
T27972	53887-53891	NNS	denotes	E2fs
T27973	53891-53892	.	denotes	.
T27974	53892-54071	sentence	denotes	In light of our findings, it will be important to reassess differentiation defects in other Rb KO tissues in the absence of individual and combined activating E2f family members.
T27975	53893-53895	IN	denotes	In
T27976	53927-53929	VB	denotes	be
T27977	53896-53901	NN	denotes	light
T27978	53902-53904	IN	denotes	of
T27979	53905-53908	PRP$	denotes	our
T27980	53909-53917	NNS	denotes	findings
T27981	53917-53919	,	denotes	,
T27982	53919-53921	PRP	denotes	it
T27983	53922-53926	MD	denotes	will
T27984	53930-53939	JJ	denotes	important
T27985	53940-53942	TO	denotes	to
T27986	53943-53951	VB	denotes	reassess
T27987	53952-53967	NN	denotes	differentiation
T27988	53968-53975	NNS	denotes	defects
T27989	53976-53978	IN	denotes	in
T27990	53979-53984	JJ	denotes	other
T27991	53991-53998	NNS	denotes	tissues
T27992	53985-53987	NN	denotes	Rb
T27993	53988-53990	NN	denotes	KO
T27994	53999-54001	IN	denotes	in
T27995	54002-54005	DT	denotes	the
T27996	54006-54013	NN	denotes	absence
T27997	54014-54016	IN	denotes	of
T27998	54017-54027	JJ	denotes	individual
T27999	54063-54070	NNS	denotes	members
T28000	54028-54031	CC	denotes	and
T28001	54032-54040	VBN	denotes	combined
T28002	54041-54051	VBG	denotes	activating
T28003	54052-54055	NN	denotes	E2f
T28004	54056-54062	NN	denotes	family
T28005	54070-54071	.	denotes	.
T28388	54171-54174	CC	denotes	and
T28389	54175-54183	JJ	denotes	national
T28375	54096-54101	NN	denotes	Mouse
T28376	54102-54109	NNS	denotes	strains
T28377	54110-54113	CC	denotes	and
T28378	54114-54124	NN	denotes	genotyping
T28379	54124-54125	.	denotes	.
T28380	54125-54195	sentence	denotes	Mice were treated according to institutional and national guidelines.
T28381	54126-54130	NNS	denotes	Mice
T28382	54136-54143	VBN	denotes	treated
T28383	54131-54135	VBD	denotes	were
T28384	54144-54153	VBG	denotes	according
T28385	54154-54156	IN	denotes	to
T28386	54157-54170	JJ	denotes	institutional
T28387	54184-54194	NNS	denotes	guidelines
T28390	54194-54195	.	denotes	.
T28391	54195-54411	sentence	denotes	α-Cre mice (P. Gruss), Chx10-Cre mice (C. Cepko), RbloxP/loxP mice (A. Berns), E2f1–/– mice, E2f2–/– mice, E2f3loxP/loxP mice, and E2f3a−/− mice were maintained on a mixed (NMRI × C57/Bl × FVB/N × 129sv) background.
T28392	54196-54197	NN	denotes	α
T28393	54198-54201	NN	denotes	Cre
T28394	54197-54198	HYPH	denotes	-
T28395	54202-54206	NNS	denotes	mice
T28396	54346-54356	VBN	denotes	maintained
T28397	54207-54208	-LRB-	denotes	(
T28398	54211-54216	NNP	denotes	Gruss
T28399	54208-54210	NNP	denotes	P.
T28400	54216-54217	-RRB-	denotes	)
T28401	54217-54219	,	denotes	,
T28402	54219-54224	NN	denotes	Chx10
T28403	54225-54228	NN	denotes	Cre
T28404	54224-54225	HYPH	denotes	-
T28405	54229-54233	NNS	denotes	mice
T28406	54234-54235	-LRB-	denotes	(
T28407	54238-54243	NNP	denotes	Cepko
T28408	54235-54237	NNP	denotes	C.
T28409	54243-54244	-RRB-	denotes	)
T28410	54244-54246	,	denotes	,
T28411	54246-54252	NN	denotes	RbloxP
T28412	54253-54257	NN	denotes	loxP
T28413	54252-54253	HYPH	denotes	/
T28414	54258-54262	NNS	denotes	mice
T28415	54263-54264	-LRB-	denotes	(
T28416	54267-54272	NNP	denotes	Berns
T28417	54264-54266	NNP	denotes	A.
T28418	54272-54273	-RRB-	denotes	)
T28419	54273-54275	,	denotes	,
T28420	54275-54279	NN	denotes	E2f1
T28421	54283-54287	NNS	denotes	mice
T28422	54279-54280	SYM	denotes	–
T28423	54280-54281	HYPH	denotes	/
T28424	54281-54282	SYM	denotes	–
T28425	54287-54289	,	denotes	,
T28426	54289-54293	NN	denotes	E2f2
T28427	54297-54301	NNS	denotes	mice
T28428	54293-54294	SYM	denotes	–
T28429	54294-54295	HYPH	denotes	/
T28430	54295-54296	SYM	denotes	–
T28431	54301-54303	,	denotes	,
T28432	54303-54311	NN	denotes	E2f3loxP
T28433	54312-54316	NN	denotes	loxP
T28434	54311-54312	HYPH	denotes	/
T28435	54317-54321	NNS	denotes	mice
T28436	54321-54323	,	denotes	,
T28437	54323-54326	CC	denotes	and
T28438	54327-54332	NN	denotes	E2f3a
T28439	54336-54340	NNS	denotes	mice
T28440	54332-54333	SYM	denotes	−
T28441	54333-54334	HYPH	denotes	/
T28442	54334-54335	SYM	denotes	−
T28443	54341-54345	VBD	denotes	were
T28444	54357-54359	IN	denotes	on
T28445	54360-54361	DT	denotes	a
T28446	54400-54410	NN	denotes	background
T28447	54362-54367	JJ	denotes	mixed
T28448	54368-54369	-LRB-	denotes	(
T28449	54369-54373	NN	denotes	NMRI
T28450	54376-54379	NN	denotes	C57
T28451	54374-54375	SYM	denotes	×
T28452	54379-54380	HYPH	denotes	/
T28453	54380-54382	NN	denotes	Bl
T28454	54385-54388	NN	denotes	FVB
T28455	54383-54384	SYM	denotes	×
T28456	54388-54389	HYPH	denotes	/
T28457	54389-54390	NN	denotes	N
T28458	54393-54398	NN	denotes	129sv
T28459	54391-54392	SYM	denotes	×
T28460	54398-54399	-RRB-	denotes	)
T28461	54410-54411	.	denotes	.
T28462	54411-54480	sentence	denotes	A detailed description of E2f3a−/− mice will be published elsewhere.
T28463	54412-54413	DT	denotes	A
T28464	54423-54434	NN	denotes	description
T28465	54414-54422	JJ	denotes	detailed
T28466	54460-54469	VBN	denotes	published
T28467	54435-54437	IN	denotes	of
T28468	54438-54443	NN	denotes	E2f3a
T28469	54447-54451	NNS	denotes	mice
T28470	54443-54444	SYM	denotes	−
T28471	54444-54445	HYPH	denotes	/
T28472	54445-54446	SYM	denotes	−
T28473	54452-54456	MD	denotes	will
T28474	54457-54459	VB	denotes	be
T28475	54470-54479	RB	denotes	elsewhere
T28476	54479-54480	.	denotes	.
T28477	54480-54584	sentence	denotes	Mice of different genotypes were compared within the same litter and across a minimum of three litters.
T28478	54481-54485	NNS	denotes	Mice
T28479	54514-54522	VBN	denotes	compared
T28480	54486-54488	IN	denotes	of
T28481	54489-54498	JJ	denotes	different
T28482	54499-54508	NNS	denotes	genotypes
T28483	54509-54513	VBD	denotes	were
T28484	54523-54529	IN	denotes	within
T28485	54530-54533	DT	denotes	the
T28486	54539-54545	NN	denotes	litter
T28487	54534-54538	JJ	denotes	same
T28488	54546-54549	CC	denotes	and
T28489	54550-54556	IN	denotes	across
T28490	54557-54558	DT	denotes	a
T28491	54559-54566	NN	denotes	minimum
T28492	54567-54569	IN	denotes	of
T28493	54570-54575	CD	denotes	three
T28494	54576-54583	NNS	denotes	litters
T28495	54583-54584	.	denotes	.
T28496	54584-54650	sentence	denotes	We have not noted any phenotypic differences in separate litters.
T28497	54585-54587	PRP	denotes	We
T28498	54597-54602	VBN	denotes	noted
T28499	54588-54592	VBP	denotes	have
T28500	54593-54596	RB	denotes	not
T28501	54603-54606	DT	denotes	any
T28502	54618-54629	NNS	denotes	differences
T28503	54607-54617	JJ	denotes	phenotypic
T28504	54630-54632	IN	denotes	in
T28505	54633-54641	JJ	denotes	separate
T28506	54642-54649	NNS	denotes	litters
T28507	54649-54650	.	denotes	.
T28508	54650-54869	sentence	denotes	Genotyping was performed as before [2,5], and the primers used for genotyping E2f3a−/− mice were E2f3a KL (5′-CTCCAGACCCCCGATTATTT-3′), E2f3a KR1 (5′-TCCAGTGCACTACTCCCTCC-3′), and E2f3a KM (5′-GCTAGCAGTGCCCTTTTGTC-3′).
T28509	54651-54661	NN	denotes	Genotyping
T28510	54666-54675	VBN	denotes	performed
T28511	54662-54665	VBD	denotes	was
T28512	54676-54678	IN	denotes	as
T28513	54679-54685	RB	denotes	before
T28514	54686-54687	-LRB-	denotes	[
T28515	54689-54690	CD	denotes	5
T28516	54687-54688	CD	denotes	2
T28517	54688-54689	,	denotes	,
T28518	54690-54691	-RRB-	denotes	]
T28519	54691-54693	,	denotes	,
T28520	54693-54696	CC	denotes	and
T28521	54697-54700	DT	denotes	the
T28522	54701-54708	NNS	denotes	primers
T28523	54743-54747	VBD	denotes	were
T28524	54709-54713	VBN	denotes	used
T28525	54714-54717	IN	denotes	for
T28526	54718-54728	VBG	denotes	genotyping
T28527	54729-54734	NN	denotes	E2f3a
T28528	54738-54742	NNS	denotes	mice
T28529	54734-54735	SYM	denotes	−
T28530	54735-54736	HYPH	denotes	/
T28531	54736-54737	SYM	denotes	−
T28532	54748-54753	NN	denotes	E2f3a
T28533	54754-54756	NN	denotes	KL
T28534	54757-54758	-LRB-	denotes	(
T28535	54758-54759	CD	denotes	5
T28536	54761-54781	NN	denotes	CTCCAGACCCCCGATTATTT
T28537	54759-54760	SYM	denotes	′
T28538	54760-54761	HYPH	denotes	-
T28539	54781-54782	HYPH	denotes	-
T28540	54782-54783	CD	denotes	3
T28541	54783-54784	SYM	denotes	′
T28542	54784-54785	-RRB-	denotes	)
T28543	54785-54787	,	denotes	,
T28544	54787-54792	NN	denotes	E2f3a
T28545	54793-54796	NN	denotes	KR1
T28546	54797-54798	-LRB-	denotes	(
T28547	54798-54799	CD	denotes	5
T28548	54801-54821	NN	denotes	TCCAGTGCACTACTCCCTCC
T28549	54799-54800	SYM	denotes	′
T28550	54800-54801	HYPH	denotes	-
T28551	54821-54822	HYPH	denotes	-
T28552	54822-54823	CD	denotes	3
T28553	54823-54824	SYM	denotes	′
T28554	54824-54825	-RRB-	denotes	)
T28555	54825-54827	,	denotes	,
T28556	54827-54830	CC	denotes	and
T28557	54831-54836	NN	denotes	E2f3a
T28558	54837-54839	NN	denotes	KM
T28559	54840-54841	-LRB-	denotes	(
T28560	54841-54842	CD	denotes	5
T28561	54844-54864	NN	denotes	GCTAGCAGTGCCCTTTTGTC
T28562	54842-54843	SYM	denotes	′
T28563	54843-54844	HYPH	denotes	-
T28564	54864-54865	HYPH	denotes	-
T28565	54865-54866	CD	denotes	3
T28566	54866-54867	SYM	denotes	′
T28567	54867-54868	-RRB-	denotes	)
T28568	54868-54869	.	denotes	.
T29662	54978-54980	,	denotes	,
T29663	54980-54988	VBN	denotes	embedded
T29664	54989-54991	IN	denotes	in
T29665	54992-54995	NN	denotes	OCT
T29666	54996-54997	-LRB-	denotes	(
T29667	54997-55006	NNP	denotes	TissueTek
T29641	54871-54880	NN	denotes	Histology
T29642	54880-54882	,	denotes	,
T29643	54882-54900	NN	denotes	immunofluorescence
T29644	54900-54902	,	denotes	,
T29645	54902-54905	CC	denotes	and
T29646	54906-54918	NNS	denotes	measurements
T29647	54918-54919	.	denotes	.
T29648	54919-55146	sentence	denotes	Eyeballs were fixed in 4% paraformaldehyde for 1 h at 4 °C, embedded in OCT (TissueTek 4583, Sakura, http://www.sakuraeu.com), frozen on dry ice, and cut into 12-μm sections on Superfrost plus slides (VWR, http://www.vwr.com).
T29649	54920-54928	NNS	denotes	Eyeballs
T29650	54934-54939	VBN	denotes	fixed
T29651	54929-54933	VBD	denotes	were
T29652	54940-54942	IN	denotes	in
T29653	54943-54944	CD	denotes	4
T29654	54944-54945	NN	denotes	%
T29655	54946-54962	NN	denotes	paraformaldehyde
T29656	54963-54966	IN	denotes	for
T29657	54967-54968	CD	denotes	1
T29658	54969-54970	NN	denotes	h
T29659	54971-54973	IN	denotes	at
T29660	54974-54975	CD	denotes	4
T29661	54976-54978	NN	denotes	°C
T29668	55007-55011	CD	denotes	4583
T29669	55011-55013	,	denotes	,
T29670	55013-55019	NNP	denotes	Sakura
T29671	55019-55021	,	denotes	,
T29672	55021-55044	NN	denotes	http://www.sakuraeu.com
T29673	55044-55045	-RRB-	denotes	)
T29674	55045-55047	,	denotes	,
T29675	55047-55053	VBN	denotes	frozen
T29676	55054-55056	IN	denotes	on
T29677	55057-55060	JJ	denotes	dry
T29678	55061-55064	NN	denotes	ice
T29679	55064-55066	,	denotes	,
T29680	55066-55069	CC	denotes	and
T29681	55070-55073	VBN	denotes	cut
T29682	55074-55078	IN	denotes	into
T29683	55079-55081	CD	denotes	12
T29684	55082-55084	NN	denotes	μm
T29685	55081-55082	HYPH	denotes	-
T29686	55085-55093	NNS	denotes	sections
T29687	55094-55096	IN	denotes	on
T29688	55097-55107	NNP	denotes	Superfrost
T29689	55113-55119	NNS	denotes	slides
T29690	55108-55112	CC	denotes	plus
T29691	55120-55121	-LRB-	denotes	(
T29692	55121-55124	NN	denotes	VWR
T29693	55124-55126	,	denotes	,
T29694	55126-55144	NN	denotes	http://www.vwr.com
T29695	55144-55145	-RRB-	denotes	)
T29696	55145-55146	.	denotes	.
T29697	55146-55254	sentence	denotes	For S-phase analysis, BrdU (100 μg/g of body weight) was injected intraperitoneally 2 h prior to sacrifice.
T29698	55147-55150	IN	denotes	For
T29699	55204-55212	VBN	denotes	injected
T29700	55151-55152	NN	denotes	S
T29701	55153-55158	NN	denotes	phase
T29702	55152-55153	HYPH	denotes	-
T29703	55159-55167	NN	denotes	analysis
T29704	55167-55169	,	denotes	,
T29705	55169-55173	NN	denotes	BrdU
T29706	55174-55175	-LRB-	denotes	(
T29707	55175-55178	CD	denotes	100
T29708	55179-55181	NN	denotes	μg
T29709	55181-55182	SYM	denotes	/
T29710	55182-55183	NN	denotes	g
T29711	55184-55186	IN	denotes	of
T29712	55187-55191	NN	denotes	body
T29713	55192-55198	NN	denotes	weight
T29714	55198-55199	-RRB-	denotes	)
T29715	55200-55203	VBD	denotes	was
T29716	55213-55230	RB	denotes	intraperitoneally
T29717	55231-55232	CD	denotes	2
T29718	55233-55234	NN	denotes	h
T29719	55241-55243	IN	denotes	to
T29720	55235-55240	JJ	denotes	prior
T29721	55244-55253	NN	denotes	sacrifice
T29722	55253-55254	.	denotes	.
T29723	55254-55406	sentence	denotes	BrdU+ cells were detected using a biotin-conjugated sheep polyclonal antibody (1:500, Maine Biotechnology Services, http://www.mainebiotechnology.com).
T29724	55255-55259	NN	denotes	BrdU
T29725	55261-55266	NNS	denotes	cells
T29726	55259-55260	SYM	denotes	+
T29727	55272-55280	VBN	denotes	detected
T29728	55267-55271	VBD	denotes	were
T29729	55281-55286	VBG	denotes	using
T29730	55287-55288	DT	denotes	a
T29731	55324-55332	NN	denotes	antibody
T29732	55289-55295	NN	denotes	biotin
T29733	55296-55306	VBN	denotes	conjugated
T29734	55295-55296	HYPH	denotes	-
T29735	55307-55312	NN	denotes	sheep
T29736	55313-55323	JJ	denotes	polyclonal
T29737	55333-55334	-LRB-	denotes	(
T29738	55361-55369	NNPS	denotes	Services
T29739	55334-55335	CD	denotes	1
T29740	55335-55336	SYM	denotes	:
T29741	55336-55339	CD	denotes	500
T29742	55339-55341	,	denotes	,
T29743	55341-55346	NNP	denotes	Maine
T29744	55347-55360	NNP	denotes	Biotechnology
T29745	55369-55371	,	denotes	,
T29746	55371-55404	NN	denotes	http://www.mainebiotechnology.com
T29747	55404-55405	-RRB-	denotes	)
T29748	55405-55406	.	denotes	.
T29749	55406-55454	sentence	denotes	All other antibodies are described in Table S1.
T29750	55407-55410	DT	denotes	All
T29751	55417-55427	NNS	denotes	antibodies
T29752	55411-55416	JJ	denotes	other
T29753	55432-55441	VBN	denotes	described
T29754	55428-55431	VBP	denotes	are
T29755	55442-55444	IN	denotes	in
T29756	55445-55450	NN	denotes	Table
T29757	55451-55453	NN	denotes	S1
T29758	55453-55454	.	denotes	.
T29759	55454-55625	sentence	denotes	For E2f3, Mki67, and Rb staining, antigen retrieval was performed by boiling sections in citric acid solution for 15 min according to Ino [50], except on frozen sections.
T29760	55455-55458	IN	denotes	For
T29761	55511-55520	VBN	denotes	performed
T29762	55459-55463	NN	denotes	E2f3
T29763	55479-55487	NN	denotes	staining
T29764	55463-55465	,	denotes	,
T29765	55465-55470	NN	denotes	Mki67
T29769	55487-55489	,	denotes	,
T29770	55489-55496	NN	denotes	antigen
T29771	55497-55506	NN	denotes	retrieval
T29772	55507-55510	VBD	denotes	was
T29773	55521-55523	IN	denotes	by
T29774	55524-55531	VBG	denotes	boiling
T29775	55532-55540	NNS	denotes	sections
T29776	55541-55543	IN	denotes	in
T29777	55544-55550	JJ	denotes	citric
T29778	55551-55555	NN	denotes	acid
T29779	55556-55564	NN	denotes	solution
T29780	55565-55568	IN	denotes	for
T29781	55569-55571	CD	denotes	15
T29782	55572-55575	NN	denotes	min
T29783	55576-55585	VBG	denotes	according
T29784	55586-55588	IN	denotes	to
T29785	55589-55592	NNP	denotes	Ino
T29786	55593-55594	-LRB-	denotes	[
T29787	55594-55596	CD	denotes	50
T29788	55596-55597	-RRB-	denotes	]
T29789	55597-55599	,	denotes	,
T29790	55599-55605	IN	denotes	except
T29791	55606-55608	IN	denotes	on
T29792	55609-55615	VBN	denotes	frozen
T29793	55616-55624	NNS	denotes	sections
T29794	55624-55625	.	denotes	.
T29795	55625-55664	sentence	denotes	TUNEL was performed as described [13].
T29796	55626-55631	NN	denotes	TUNEL
T29797	55636-55645	VBN	denotes	performed
T29798	55632-55635	VBD	denotes	was
T29799	55646-55648	IN	denotes	as
T29800	55649-55658	VBN	denotes	described
T29801	55659-55660	-LRB-	denotes	[
T29802	55660-55662	CD	denotes	13
T29803	55662-55663	-RRB-	denotes	]
T29804	55663-55664	.	denotes	.
T29805	55664-55935	sentence	denotes	Briefly, sections were incubated for 1 h at 37 °C with 75 μl of mixture solution consisting of 0.5 μl of terminal deoxynucleotide transferase, 1 μl of biotin-16-dUTP, 7.5 μl of CoCl2, 15 μl of 5× terminal deoxynucleotide transferase buffer, and 51 μl of distilled water.
T29806	55665-55672	RB	denotes	Briefly
T29807	55688-55697	VBN	denotes	incubated
T29808	55672-55674	,	denotes	,
T29809	55674-55682	NNS	denotes	sections
T29810	55683-55687	VBD	denotes	were
T29811	55698-55701	IN	denotes	for
T29812	55702-55703	CD	denotes	1
T29813	55704-55705	NN	denotes	h
T29814	55706-55708	IN	denotes	at
T29815	55709-55711	CD	denotes	37
T29816	55712-55714	NN	denotes	°C
T29817	55715-55719	IN	denotes	with
T29818	55720-55722	CD	denotes	75
T29819	55723-55725	NN	denotes	μl
T29820	55726-55728	IN	denotes	of
T29821	55729-55736	NN	denotes	mixture
T29822	55737-55745	NN	denotes	solution
T29823	55746-55756	VBG	denotes	consisting
T29824	55757-55759	IN	denotes	of
T29825	55760-55763	CD	denotes	0.5
T29826	55764-55766	NN	denotes	μl
T29827	55767-55769	IN	denotes	of
T29828	55770-55778	JJ	denotes	terminal
T29829	55795-55806	NN	denotes	transferase
T29830	55779-55794	NN	denotes	deoxynucleotide
T29831	55806-55808	,	denotes	,
T29832	55808-55809	CD	denotes	1
T29833	55810-55812	NN	denotes	μl
T29834	55813-55815	IN	denotes	of
T29835	55816-55822	NN	denotes	biotin
T29836	55826-55830	NN	denotes	dUTP
T29837	55822-55823	HYPH	denotes	-
T29838	55823-55825	CD	denotes	16
T29839	55825-55826	HYPH	denotes	-
T29840	55830-55832	,	denotes	,
T29841	55832-55835	CD	denotes	7.5
T29842	55836-55838	NN	denotes	μl
T29843	55839-55841	IN	denotes	of
T29844	55842-55847	NN	denotes	CoCl2
T29845	55847-55849	,	denotes	,
T29846	55849-55851	CD	denotes	15
T29847	55852-55854	NN	denotes	μl
T29848	55855-55857	IN	denotes	of
T29849	55858-55859	CD	denotes	5
T29850	55898-55904	NN	denotes	buffer
T29851	55859-55860	SYM	denotes	×
T29852	55861-55869	JJ	denotes	terminal
T29853	55886-55897	NN	denotes	transferase
T29854	55870-55885	NN	denotes	deoxynucleotide
T29855	55904-55906	,	denotes	,
T29856	55906-55909	CC	denotes	and
T29857	55910-55912	CD	denotes	51
T29858	55913-55915	NN	denotes	μl
T29859	55916-55918	IN	denotes	of
T29860	55919-55928	VBN	denotes	distilled
T29861	55929-55934	NN	denotes	water
T29862	55934-55935	.	denotes	.
T29863	55935-56125	sentence	denotes	After three washes in 4× SSC buffer, sections were incubated with Alexa 488– or Alexa 568−streptavidin (1:1,000; Molecular Probes, http://probes.invitrogen.com) for 1 h at room temperature.
T29864	55936-55941	IN	denotes	After
T29865	55987-55996	VBN	denotes	incubated
T29866	55942-55947	CD	denotes	three
T29867	55948-55954	NNS	denotes	washes
T29868	55955-55957	IN	denotes	in
T29869	55958-55959	CD	denotes	4
T29870	55965-55971	NN	denotes	buffer
T29871	55959-55960	SYM	denotes	×
T29872	55961-55964	NN	denotes	SSC
T29873	55971-55973	,	denotes	,
T29874	55973-55981	NNS	denotes	sections
T29875	55982-55986	VBD	denotes	were
T29876	55997-56001	IN	denotes	with
T29877	56002-56007	NNP	denotes	Alexa
T29878	56026-56038	NN	denotes	streptavidin
T29879	56008-56011	CD	denotes	488
T29880	56011-56012	HYPH	denotes	–
T29881	56013-56015	CC	denotes	or
T29882	56016-56021	NNP	denotes	Alexa
T29883	56022-56025	CD	denotes	568
T29884	56025-56026	HYPH	denotes	−
T29885	56039-56040	-LRB-	denotes	(
T29886	56059-56065	NNP	denotes	Probes
T29887	56040-56041	CD	denotes	1
T29888	56041-56042	SYM	denotes	:
T29889	56042-56047	CD	denotes	1,000
T29890	56047-56048	:	denotes	;
T29891	56049-56058	NNP	denotes	Molecular
T29892	56065-56067	,	denotes	,
T29893	56067-56095	NN	denotes	http://probes.invitrogen.com
T29894	56095-56096	-RRB-	denotes	)
T29895	56097-56100	IN	denotes	for
T29896	56101-56102	CD	denotes	1
T29897	56103-56104	NN	denotes	h
T29898	56105-56107	IN	denotes	at
T29899	56108-56112	NN	denotes	room
T29900	56113-56124	NN	denotes	temperature
T29901	56124-56125	.	denotes	.
T29902	56125-56379	sentence	denotes	Primary antibodies or labelled cells were visualized using donkey anti-mouse Alexa 488 or Alexa 568, donkey anti-rabbit Alexa 488 or Alexa 568, donkey anti-goat Alexa 488 or Alexa 568, and streptavidin Alexa 488 or Alexa 568 (1:1,000; Molecular Probes).
T29903	56126-56133	JJ	denotes	Primary
T29904	56134-56144	NNS	denotes	antibodies
T29905	56168-56178	VBN	denotes	visualized
T29906	56145-56147	CC	denotes	or
T29907	56148-56156	VBN	denotes	labelled
T29908	56157-56162	NNS	denotes	cells
T29909	56163-56167	VBD	denotes	were
T29910	56179-56184	VBG	denotes	using
T29911	56185-56191	NN	denotes	donkey
T29912	56203-56208	NNP	denotes	Alexa
T29913	56192-56202	JJ	denotes	anti-mouse
T29914	56209-56212	CD	denotes	488
T29915	56213-56215	CC	denotes	or
T29916	56216-56221	NNP	denotes	Alexa
T29917	56222-56225	CD	denotes	568
T29918	56225-56227	,	denotes	,
T29919	56227-56233	NN	denotes	donkey
T29920	56246-56251	NNP	denotes	Alexa
T29921	56234-56245	JJ	denotes	anti-rabbit
T29922	56252-56255	CD	denotes	488
T29923	56256-56258	CC	denotes	or
T29924	56259-56264	NNP	denotes	Alexa
T29925	56265-56268	CD	denotes	568
T29926	56268-56270	,	denotes	,
T29927	56270-56276	NN	denotes	donkey
T29928	56287-56292	NNP	denotes	Alexa
T29929	56277-56286	JJ	denotes	anti-goat
T29930	56293-56296	CD	denotes	488
T29931	56297-56299	CC	denotes	or
T29932	56300-56305	NNP	denotes	Alexa
T29933	56306-56309	CD	denotes	568
T29934	56309-56311	,	denotes	,
T29935	56311-56314	CC	denotes	and
T29936	56315-56327	NN	denotes	streptavidin
T29937	56328-56333	NNP	denotes	Alexa
T29938	56334-56337	CD	denotes	488
T29939	56338-56340	CC	denotes	or
T29940	56341-56346	NNP	denotes	Alexa
T29941	56347-56350	CD	denotes	568
T29942	56351-56352	-LRB-	denotes	(
T29943	56371-56377	NNP	denotes	Probes
T29944	56352-56353	CD	denotes	1
T29945	56353-56354	SYM	denotes	:
T29946	56354-56359	CD	denotes	1,000
T29947	56359-56360	:	denotes	;
T29948	56361-56370	NNP	denotes	Molecular
T29949	56377-56378	-RRB-	denotes	)
T29950	56378-56379	.	denotes	.
T29951	56379-56484	sentence	denotes	Nuclei were counter-stained with 4,6-diamidino-2-phenyindole (DAPI; Sigma, http://www.sigmaaldrich.com).
T29952	56380-56386	NNS	denotes	Nuclei
T29953	56400-56407	VBN	denotes	stained
T29954	56387-56391	VBD	denotes	were
T29955	56392-56399	RB	denotes	counter
T29956	56399-56400	HYPH	denotes	-
T29957	56408-56412	IN	denotes	with
T29958	56413-56414	CD	denotes	4
T29959	56417-56426	NN	denotes	diamidino
T29960	56414-56415	,	denotes	,
T29961	56415-56416	CD	denotes	6
T29962	56416-56417	HYPH	denotes	-
T29963	56429-56440	NN	denotes	phenyindole
T29964	56426-56427	HYPH	denotes	-
T29965	56427-56428	CD	denotes	2
T29966	56428-56429	HYPH	denotes	-
T29967	56441-56442	-LRB-	denotes	(
T29968	56442-56446	NN	denotes	DAPI
T29969	56446-56447	:	denotes	;
T29970	56448-56453	NN	denotes	Sigma
T29971	56453-56455	,	denotes	,
T29972	56455-56482	NN	denotes	http://www.sigmaaldrich.com
T29973	56482-56483	-RRB-	denotes	)
T29974	56483-56484	.	denotes	.
T29975	56484-56654	sentence	denotes	Labelled cells were visualized using a Zeiss (http://www.zeiss.com) Axioplan-2 microscope with Plan Neofluar objectives and images captured with a Zeiss AxionCam camera.
T29976	56485-56493	VBN	denotes	Labelled
T29977	56494-56499	NNS	denotes	cells
T29978	56505-56515	VBN	denotes	visualized
T29979	56500-56504	VBD	denotes	were
T29980	56516-56521	VBG	denotes	using
T29981	56522-56523	DT	denotes	a
T29982	56564-56574	NN	denotes	microscope
T29983	56524-56529	NNP	denotes	Zeiss
T29984	56530-56531	-LRB-	denotes	(
T29985	56531-56551	NN	denotes	http://www.zeiss.com
T29986	56551-56552	-RRB-	denotes	)
T29987	56553-56561	NN	denotes	Axioplan
T29988	56561-56562	HYPH	denotes	-
T29989	56562-56563	CD	denotes	2
T29990	56575-56579	IN	denotes	with
T29991	56580-56584	NNP	denotes	Plan
T29992	56585-56593	NNP	denotes	Neofluar
T29993	56594-56604	NNS	denotes	objectives
T29994	56605-56608	CC	denotes	and
T29995	56609-56615	NNS	denotes	images
T29996	56616-56624	VBN	denotes	captured
T29997	56625-56629	IN	denotes	with
T29998	56630-56631	DT	denotes	a
T29999	56647-56653	NN	denotes	camera
T30000	56632-56637	NNP	denotes	Zeiss
T30001	56638-56646	NNP	denotes	AxionCam
T30002	56653-56654	.	denotes	.
T30003	56654-56761	sentence	denotes	For double-labelled samples, confocal images were obtained with a Zeiss LSM 5.0 laser scanning microscope.
T30004	56655-56658	IN	denotes	For
T30005	56705-56713	VBN	denotes	obtained
T30006	56659-56665	JJ	denotes	double
T30007	56666-56674	VBN	denotes	labelled
T30008	56665-56666	HYPH	denotes	-
T30009	56675-56682	NNS	denotes	samples
T30010	56682-56684	,	denotes	,
T30011	56684-56692	JJ	denotes	confocal
T30012	56693-56699	NNS	denotes	images
T30013	56700-56704	VBD	denotes	were
T30014	56714-56718	IN	denotes	with
T30015	56719-56720	DT	denotes	a
T30016	56750-56760	NN	denotes	microscope
T30017	56721-56726	NNP	denotes	Zeiss
T30018	56727-56730	NNP	denotes	LSM
T30019	56731-56734	CD	denotes	5.0
T30020	56735-56740	NN	denotes	laser
T30021	56741-56749	NN	denotes	scanning
T30022	56760-56761	.	denotes	.
T30023	56761-56912	sentence	denotes	The retina was separated into three bins by dividing the ventricular edge of the retina into equal parts and extending a line to the vitreal edge [2].
T30024	56762-56765	DT	denotes	The
T30025	56766-56772	NN	denotes	retina
T30026	56777-56786	VBN	denotes	separated
T30027	56773-56776	VBD	denotes	was
T30028	56787-56791	IN	denotes	into
T30029	56792-56797	CD	denotes	three
T30030	56798-56802	NNS	denotes	bins
T30031	56803-56805	IN	denotes	by
T30032	56806-56814	VBG	denotes	dividing
T30033	56815-56818	DT	denotes	the
T30034	56831-56835	NN	denotes	edge
T30035	56819-56830	JJ	denotes	ventricular
T30036	56836-56838	IN	denotes	of
T30037	56839-56842	DT	denotes	the
T30038	56843-56849	NN	denotes	retina
T30039	56850-56854	IN	denotes	into
T30040	56855-56860	JJ	denotes	equal
T30041	56861-56866	NNS	denotes	parts
T30042	56867-56870	CC	denotes	and
T30043	56871-56880	VBG	denotes	extending
T30044	56881-56882	DT	denotes	a
T30045	56883-56887	NN	denotes	line
T30046	56888-56890	IN	denotes	to
T30047	56891-56894	DT	denotes	the
T30048	56903-56907	NN	denotes	edge
T30049	56895-56902	JJ	denotes	vitreal
T30050	56908-56909	-LRB-	denotes	[
T30051	56909-56910	CD	denotes	2
T30052	56910-56911	-RRB-	denotes	]
T30053	56911-56912	.	denotes	.
T30054	56912-57070	sentence	denotes	Bin 1 contains only cells that expressed Cre as progenitors; bin 3 is at central retina and contains cells derived from progenitors that did not express Cre.
T30055	56913-56916	NN	denotes	Bin
T30056	56919-56927	VBZ	denotes	contains
T30057	56917-56918	CD	denotes	1
T30058	56980-56982	VBZ	denotes	is
T30059	56928-56932	JJ	denotes	only
T30060	56933-56938	NNS	denotes	cells
T30061	56939-56943	WDT	denotes	that
T30062	56944-56953	VBD	denotes	expressed
T30063	56954-56957	NN	denotes	Cre
T30064	56958-56960	IN	denotes	as
T30065	56961-56972	NNS	denotes	progenitors
T30066	56972-56973	:	denotes	;
T30067	56974-56977	NN	denotes	bin
T30068	56978-56979	CD	denotes	3
T30069	56983-56985	IN	denotes	at
T30070	56986-56993	JJ	denotes	central
T30071	56994-57000	NN	denotes	retina
T30072	57001-57004	CC	denotes	and
T30073	57005-57013	VBZ	denotes	contains
T30074	57014-57019	NNS	denotes	cells
T30075	57020-57027	VBN	denotes	derived
T30076	57028-57032	IN	denotes	from
T30077	57033-57044	NNS	denotes	progenitors
T30078	57045-57049	WDT	denotes	that
T30079	57058-57065	VB	denotes	express
T30080	57050-57053	VBD	denotes	did
T30081	57054-57057	RB	denotes	not
T30082	57066-57069	NN	denotes	Cre
T30083	57069-57070	.	denotes	.
T30084	57070-57189	sentence	denotes	For cell counts or thickness measurement we used a region 0–100 μm peripheral to the boundary separating bins 1 and 2.
T30085	57071-57074	IN	denotes	For
T30086	57115-57119	VBD	denotes	used
T30087	57075-57079	NN	denotes	cell
T30088	57080-57086	NNS	denotes	counts
T30089	57087-57089	CC	denotes	or
T30090	57090-57099	NN	denotes	thickness
T30091	57100-57111	NN	denotes	measurement
T30092	57112-57114	PRP	denotes	we
T30093	57120-57121	DT	denotes	a
T30094	57122-57128	NN	denotes	region
T30095	57129-57130	CD	denotes	0
T30096	57131-57134	CD	denotes	100
T30097	57130-57131	SYM	denotes	–
T30098	57135-57137	NN	denotes	μm
T30099	57138-57148	JJ	denotes	peripheral
T30100	57149-57151	IN	denotes	to
T30101	57152-57155	DT	denotes	the
T30102	57156-57164	NN	denotes	boundary
T30103	57165-57175	VBG	denotes	separating
T30104	57176-57180	NNS	denotes	bins
T30105	57181-57182	CD	denotes	1
T30106	57183-57186	CC	denotes	and
T30107	57187-57188	CD	denotes	2
T30108	57188-57189	.	denotes	.
T30109	57189-57271	sentence	denotes	Measurements were performed on an Axioplan-2 microscope using Axiovison software.
T30110	57190-57202	NNS	denotes	Measurements
T30111	57208-57217	VBN	denotes	performed
T30112	57203-57207	VBD	denotes	were
T30113	57218-57220	IN	denotes	on
T30114	57221-57223	DT	denotes	an
T30115	57235-57245	NN	denotes	microscope
T30116	57224-57232	NN	denotes	Axioplan
T30117	57232-57233	HYPH	denotes	-
T30118	57233-57234	CD	denotes	2
T30119	57246-57251	VBG	denotes	using
T30120	57252-57261	NNP	denotes	Axiovison
T30121	57262-57270	NN	denotes	software
T30122	57270-57271	.	denotes	.
T30123	57271-57395	sentence	denotes	Quantification of S-phase, M-phase, and apoptotic cells was performed on horizontal sections that included the optic nerve.
T30124	57272-57286	NN	denotes	Quantification
T30125	57332-57341	VBN	denotes	performed
T30126	57287-57289	IN	denotes	of
T30127	57290-57291	NN	denotes	S
T30128	57292-57297	NN	denotes	phase
T30129	57291-57292	HYPH	denotes	-
T30130	57322-57327	NNS	denotes	cells
T30131	57297-57299	,	denotes	,
T30132	57299-57300	NN	denotes	M
T30133	57301-57306	NN	denotes	phase
T30134	57300-57301	HYPH	denotes	-
T30135	57306-57308	,	denotes	,
T30136	57308-57311	CC	denotes	and
T30137	57312-57321	JJ	denotes	apoptotic
T30138	57328-57331	VBD	denotes	was
T30139	57342-57344	IN	denotes	on
T30140	57345-57355	JJ	denotes	horizontal
T30141	57356-57364	NNS	denotes	sections
T30142	57365-57369	WDT	denotes	that
T30143	57370-57378	VBD	denotes	included
T30144	57379-57382	DT	denotes	the
T30145	57389-57394	NN	denotes	nerve
T30146	57383-57388	JJ	denotes	optic
T30147	57394-57395	.	denotes	.
T30148	57395-57520	sentence	denotes	Quantification of differentiated cell types was performed using horizontal sections at equal distances from the optic nerve.
T30149	57396-57410	NN	denotes	Quantification
T30150	57444-57453	VBN	denotes	performed
T30151	57411-57413	IN	denotes	of
T30152	57414-57428	VBN	denotes	differentiated
T30153	57434-57439	NNS	denotes	types
T30154	57429-57433	NN	denotes	cell
T30155	57440-57443	VBD	denotes	was
T30156	57454-57459	VBG	denotes	using
T30157	57460-57470	JJ	denotes	horizontal
T30158	57471-57479	NNS	denotes	sections
T30159	57480-57482	IN	denotes	at
T30160	57483-57488	JJ	denotes	equal
T30161	57489-57498	NNS	denotes	distances
T30162	57499-57503	IN	denotes	from
T30163	57504-57507	DT	denotes	the
T30164	57514-57519	NN	denotes	nerve
T30165	57508-57513	JJ	denotes	optic
T30166	57519-57520	.	denotes	.
T30167	57520-57608	sentence	denotes	A minimum of three sections per eye and three eyes from different litters were counted.
T30168	57521-57522	DT	denotes	A
T30169	57523-57530	NN	denotes	minimum
T30170	57600-57607	VBN	denotes	counted
T30171	57531-57533	IN	denotes	of
T30172	57534-57539	CD	denotes	three
T30173	57540-57548	NNS	denotes	sections
T30174	57549-57552	IN	denotes	per
T30175	57553-57556	NN	denotes	eye
T30176	57557-57560	CC	denotes	and
T30177	57561-57566	CD	denotes	three
T30178	57567-57571	NNS	denotes	eyes
T30179	57572-57576	IN	denotes	from
T30180	57577-57586	JJ	denotes	different
T30181	57587-57594	NNS	denotes	litters
T30182	57595-57599	VBD	denotes	were
T30183	57607-57608	.	denotes	.
T30759	57610-57613	NN	denotes	RNA
T30760	57614-57624	NN	denotes	extraction
T30761	57624-57626	,	denotes	,
T30762	57626-57633	JJ	denotes	reverse
T30763	57634-57647	NN	denotes	transcription
T30764	57647-57649	,	denotes	,
T30765	57649-57652	CC	denotes	and
T30766	57653-57656	NN	denotes	PCR
T30767	57656-57657	.	denotes	.
T30768	57657-57889	sentence	denotes	Total RNA was isolated from dissected peripheral retina using TRIzol reagent (Invitrogen, http://www.invitrogen.com) followed by digestion with RNase-free DNase (DNA-free, Ambion, http://www.ambion.com) to remove DNA contamination.
T30769	57658-57663	JJ	denotes	Total
T30770	57664-57667	NN	denotes	RNA
T30771	57672-57680	VBN	denotes	isolated
T30772	57668-57671	VBD	denotes	was
T30773	57681-57685	IN	denotes	from
T30774	57686-57695	VBN	denotes	dissected
T30775	57707-57713	NN	denotes	retina
T30776	57696-57706	JJ	denotes	peripheral
T30777	57714-57719	VBG	denotes	using
T30778	57720-57726	NN	denotes	TRIzol
T30779	57727-57734	NN	denotes	reagent
T30780	57735-57736	-LRB-	denotes	(
T30781	57736-57746	NNP	denotes	Invitrogen
T30782	57746-57748	,	denotes	,
T30783	57748-57773	NN	denotes	http://www.invitrogen.com
T30784	57773-57774	-RRB-	denotes	)
T30785	57775-57783	VBN	denotes	followed
T30786	57784-57786	IN	denotes	by
T30787	57787-57796	NN	denotes	digestion
T30788	57797-57801	IN	denotes	with
T30789	57802-57807	NN	denotes	RNase
T30790	57808-57812	JJ	denotes	free
T30791	57807-57808	HYPH	denotes	-
T30792	57813-57818	NN	denotes	DNase
T30793	57819-57820	-LRB-	denotes	(
T30794	57820-57823	NN	denotes	DNA
T30795	57823-57824	HYPH	denotes	-
T30796	57824-57828	JJ	denotes	free
T30797	57828-57830	,	denotes	,
T30798	57830-57836	NNP	denotes	Ambion
T30799	57836-57838	,	denotes	,
T30800	57838-57859	NN	denotes	http://www.ambion.com
T30801	57859-57860	-RRB-	denotes	)
T30802	57861-57863	TO	denotes	to
T30803	57864-57870	VB	denotes	remove
T30804	57871-57874	NN	denotes	DNA
T30805	57875-57888	NN	denotes	contamination
T30806	57888-57889	.	denotes	.
T30807	57889-58021	sentence	denotes	First-strand cDNA was synthesized from 0.2–0.5 μg of total RNA using the SuperScript II first-strand synthesis system (Invitrogen).
T30808	57890-57895	JJ	denotes	First
T30809	57896-57902	NN	denotes	strand
T30810	57895-57896	HYPH	denotes	-
T30811	57903-57907	NN	denotes	cDNA
T30812	57912-57923	VBN	denotes	synthesized
T30813	57908-57911	VBD	denotes	was
T30814	57924-57928	IN	denotes	from
T30815	57929-57932	CD	denotes	0.2
T30816	57933-57936	CD	denotes	0.5
T30817	57932-57933	SYM	denotes	–
T30818	57937-57939	NN	denotes	μg
T30819	57940-57942	IN	denotes	of
T30820	57943-57948	JJ	denotes	total
T30821	57949-57952	NN	denotes	RNA
T30822	57953-57958	VBG	denotes	using
T30823	57959-57962	DT	denotes	the
T30824	58001-58007	NN	denotes	system
T30825	57963-57974	NNP	denotes	SuperScript
T30826	57975-57977	CD	denotes	II
T30827	57978-57983	JJ	denotes	first
T30828	57984-57990	NN	denotes	strand
T30829	57983-57984	HYPH	denotes	-
T30830	57991-58000	NN	denotes	synthesis
T30831	58008-58009	-LRB-	denotes	(
T30832	58009-58019	NNP	denotes	Invitrogen
T30833	58019-58020	-RRB-	denotes	)
T30834	58020-58021	.	denotes	.
T30835	58021-58057	sentence	denotes	PCR primers are listed in Table S2.
T30836	58022-58025	NN	denotes	PCR
T30837	58026-58033	NNS	denotes	primers
T30838	58038-58044	VBN	denotes	listed
T30839	58034-58037	VBP	denotes	are
T30840	58045-58047	IN	denotes	in
T30841	58048-58053	NN	denotes	Table
T30842	58054-58056	NN	denotes	S2
T30843	58056-58057	.	denotes	.
T30844	58057-58171	sentence	denotes	Real-time quantitative PCR was performed using an Applied Biosystems (http://appliedbiosystems.com) PRISM 7900HT.
T30845	58058-58062	JJ	denotes	Real
T30846	58063-58067	NN	denotes	time
T30847	58062-58063	HYPH	denotes	-
T30848	58081-58084	NN	denotes	PCR
T30849	58068-58080	JJ	denotes	quantitative
T30850	58089-58098	VBN	denotes	performed
T30851	58085-58088	VBD	denotes	was
T30852	58099-58104	VBG	denotes	using
T30853	58105-58107	DT	denotes	an
T30854	58164-58170	NN	denotes	7900HT
T30855	58108-58115	NNP	denotes	Applied
T30856	58116-58126	NNP	denotes	Biosystems
T30857	58127-58128	-LRB-	denotes	(
T30858	58128-58156	NN	denotes	http://appliedbiosystems.com
T30859	58156-58157	-RRB-	denotes	)
T30860	58158-58163	NNP	denotes	PRISM
T30861	58170-58171	.	denotes	.
T30862	58171-58329	sentence	denotes	Tests were run in duplicate on three separate biological samples with SYBR Green PCR Master Mix (Applied Biosystems) exactly as we described previously [71].
T30863	58172-58177	NNS	denotes	Tests
T30864	58183-58186	VBN	denotes	run
T30865	58178-58182	VBD	denotes	were
T30866	58187-58189	IN	denotes	in
T30867	58190-58199	NN	denotes	duplicate
T30868	58200-58202	IN	denotes	on
T30869	58203-58208	CD	denotes	three
T30870	58229-58236	NNS	denotes	samples
T30871	58209-58217	JJ	denotes	separate
T30872	58218-58228	JJ	denotes	biological
T30873	58237-58241	IN	denotes	with
T30874	58242-58246	NN	denotes	SYBR
T30875	58264-58267	NNP	denotes	Mix
T30876	58247-58252	JJ	denotes	Green
T30877	58253-58256	NN	denotes	PCR
T30878	58257-58263	NNP	denotes	Master
T30879	58268-58269	-LRB-	denotes	(
T30880	58277-58287	NNP	denotes	Biosystems
T30881	58269-58276	NNP	denotes	Applied
T30882	58287-58288	-RRB-	denotes	)
T30883	58289-58296	RB	denotes	exactly
T30884	58303-58312	VBD	denotes	described
T30885	58297-58299	IN	denotes	as
T30886	58300-58302	PRP	denotes	we
T30887	58313-58323	RB	denotes	previously
T30888	58324-58325	-LRB-	denotes	[
T30889	58325-58327	CD	denotes	71
T30890	58327-58328	-RRB-	denotes	]
T30891	58328-58329	.	denotes	.
T30892	58329-58662	sentence	denotes	Briefly, master stocks were prepared such that each 10-μl reaction contained 5 μl of SYBR Green PCR Master Mix, 0.1 μl of each forward and reverse primer (stock 50 μM), 0.8 μl of blue H2O (0.73% Blue Food Colour; McCormick, http://www.mccormick.com), 2 μl of diluted cDNA template, and 2 μl of yellow H2O (0.73% Yellow Food Colour).
T30893	58330-58337	RB	denotes	Briefly
T30894	58358-58366	VBN	denotes	prepared
T30895	58337-58339	,	denotes	,
T30896	58339-58345	NN	denotes	master
T30897	58346-58352	NNS	denotes	stocks
T30898	58353-58357	VBD	denotes	were
T30899	58367-58371	JJ	denotes	such
T30900	58397-58406	VBD	denotes	contained
T30901	58372-58376	IN	denotes	that
T30902	58377-58381	DT	denotes	each
T30903	58388-58396	NN	denotes	reaction
T30904	58382-58384	CD	denotes	10
T30905	58385-58387	NN	denotes	μl
T30906	58384-58385	HYPH	denotes	-
T30907	58407-58408	CD	denotes	5
T30908	58409-58411	NN	denotes	μl
T30909	58412-58414	IN	denotes	of
T30910	58415-58419	NNP	denotes	SYBR
T30911	58437-58440	NN	denotes	Mix
T30912	58420-58425	JJ	denotes	Green
T30913	58426-58429	NN	denotes	PCR
T30914	58430-58436	NN	denotes	Master
T30915	58440-58442	,	denotes	,
T30916	58442-58445	CD	denotes	0.1
T30917	58446-58448	NN	denotes	μl
T30918	58449-58451	IN	denotes	of
T30919	58452-58456	DT	denotes	each
T30920	58477-58483	NN	denotes	primer
T30921	58457-58464	JJ	denotes	forward
T30922	58465-58468	CC	denotes	and
T30923	58469-58476	JJ	denotes	reverse
T30924	58484-58485	-LRB-	denotes	(
T30925	58494-58496	NN	denotes	μM
T30926	58485-58490	NN	denotes	stock
T30927	58491-58493	CD	denotes	50
T30928	58496-58497	-RRB-	denotes	)
T30929	58497-58499	,	denotes	,
T30930	58499-58502	CD	denotes	0.8
T30931	58503-58505	NN	denotes	μl
T30932	58506-58508	IN	denotes	of
T30933	58509-58513	JJ	denotes	blue
T30934	58514-58517	NN	denotes	H2O
T30935	58518-58519	-LRB-	denotes	(
T30936	58543-58552	NNP	denotes	McCormick
T30937	58519-58523	CD	denotes	0.73
T30938	58523-58524	NN	denotes	%
T30939	58535-58541	NNP	denotes	Colour
T30940	58525-58529	NNP	denotes	Blue
T30941	58530-58534	NNP	denotes	Food
T30942	58541-58542	:	denotes	;
T30943	58552-58554	,	denotes	,
T30944	58554-58578	NN	denotes	http://www.mccormick.com
T30945	58578-58579	-RRB-	denotes	)
T30946	58579-58581	,	denotes	,
T30947	58581-58582	CD	denotes	2
T30948	58583-58585	NN	denotes	μl
T30949	58586-58588	IN	denotes	of
T30950	58589-58596	VBN	denotes	diluted
T30951	58602-58610	NN	denotes	template
T30952	58597-58601	NN	denotes	cDNA
T30953	58610-58612	,	denotes	,
T30954	58612-58615	CC	denotes	and
T30955	58616-58617	CD	denotes	2
T30956	58618-58620	NN	denotes	μl
T30957	58621-58623	IN	denotes	of
T30958	58624-58630	JJ	denotes	yellow
T30959	58631-58634	NN	denotes	H2O
T30960	58635-58636	-LRB-	denotes	(
T30961	58654-58660	NN	denotes	Colour
T30962	58636-58640	CD	denotes	0.73
T30963	58640-58641	NN	denotes	%
T30964	58642-58648	JJ	denotes	Yellow
T30965	58649-58653	NN	denotes	Food
T30966	58660-58661	-RRB-	denotes	)
T30967	58661-58662	.	denotes	.
T30968	58662-58770	sentence	denotes	PCR consisted of 40 cycles of denaturation at 95 °C for 15 s and annealing and extension at 55 °C for 30 s.
T30969	58663-58666	NN	denotes	PCR
T30970	58667-58676	VBD	denotes	consisted
T30971	58677-58679	IN	denotes	of
T30972	58680-58682	CD	denotes	40
T30973	58683-58689	NNS	denotes	cycles
T30974	58690-58692	IN	denotes	of
T30975	58693-58705	NN	denotes	denaturation
T30976	58706-58708	IN	denotes	at
T30977	58709-58711	CD	denotes	95
T30978	58712-58714	NN	denotes	°C
T30979	58715-58718	IN	denotes	for
T30980	58719-58721	CD	denotes	15
T30981	58722-58723	NN	denotes	s
T30982	58724-58727	CC	denotes	and
T30983	58728-58737	NN	denotes	annealing
T30984	58738-58741	CC	denotes	and
T30985	58742-58751	NN	denotes	extension
T30986	58752-58754	IN	denotes	at
T30987	58755-58757	CD	denotes	55
T30988	58758-58760	NN	denotes	°C
T30989	58761-58764	IN	denotes	for
T30990	58765-58767	CD	denotes	30
T30991	58768-58769	NN	denotes	s
T30992	58769-58770	.	denotes	.
T30993	58770-58871	sentence	denotes	An additional cycle (95 °C, 15 s, 60 °C) generated a dissociation curve to confirm a single product.
T30994	58771-58773	DT	denotes	An
T30995	58785-58790	NN	denotes	cycle
T30996	58774-58784	JJ	denotes	additional
T30997	58812-58821	VBD	denotes	generated
T30998	58791-58792	-LRB-	denotes	(
T30999	58808-58810	NN	denotes	°C
T31000	58792-58794	CD	denotes	95
T31001	58795-58797	NN	denotes	°C
T31002	58797-58799	,	denotes	,
T31003	58799-58801	CD	denotes	15
T31004	58802-58803	NN	denotes	s
T31005	58803-58805	,	denotes	,
T31006	58805-58807	CD	denotes	60
T31007	58810-58811	-RRB-	denotes	)
T31008	58822-58823	DT	denotes	a
T31009	58837-58842	NN	denotes	curve
T31010	58824-58836	NN	denotes	dissociation
T31011	58843-58845	TO	denotes	to
T31012	58846-58853	VB	denotes	confirm
T31013	58854-58855	DT	denotes	a
T31014	58863-58870	NN	denotes	product
T31015	58856-58862	JJ	denotes	single
T31016	58870-58871	.	denotes	.
T31017	58871-59098	sentence	denotes	The cycle quantity required to reach a threshold in the linear range was determined and compared to a standard curve for each primer set generated by five 3-fold dilutions of genomic DNA or cDNA samples of known concentration.
T31018	58872-58875	DT	denotes	The
T31019	58882-58890	NN	denotes	quantity
T31020	58876-58881	NN	denotes	cycle
T31021	58945-58955	VBN	denotes	determined
T31022	58891-58899	VBN	denotes	required
T31023	58900-58902	TO	denotes	to
T31024	58903-58908	VB	denotes	reach
T31025	58909-58910	DT	denotes	a
T31026	58911-58920	NN	denotes	threshold
T31027	58921-58923	IN	denotes	in
T31028	58924-58927	DT	denotes	the
T31029	58935-58940	NN	denotes	range
T31030	58928-58934	JJ	denotes	linear
T31031	58941-58944	VBD	denotes	was
T31032	58956-58959	CC	denotes	and
T31033	58960-58968	VBN	denotes	compared
T31034	58969-58971	IN	denotes	to
T31035	58972-58973	DT	denotes	a
T31036	58983-58988	NN	denotes	curve
T31037	58974-58982	JJ	denotes	standard
T31038	58989-58992	IN	denotes	for
T31039	58993-58997	DT	denotes	each
T31040	59005-59008	NN	denotes	set
T31041	58998-59004	NN	denotes	primer
T31042	59009-59018	VBN	denotes	generated
T31043	59019-59021	IN	denotes	by
T31044	59022-59026	CD	denotes	five
T31045	59034-59043	NNS	denotes	dilutions
T31046	59027-59028	CD	denotes	3
T31047	59028-59029	HYPH	denotes	-
T31048	59029-59033	JJ	denotes	fold
T31049	59044-59046	IN	denotes	of
T31050	59047-59054	JJ	denotes	genomic
T31051	59067-59074	NNS	denotes	samples
T31052	59055-59058	NN	denotes	DNA
T31053	59059-59061	CC	denotes	or
T31054	59062-59066	NN	denotes	cDNA
T31055	59075-59077	IN	denotes	of
T31056	59078-59083	JJ	denotes	known
T31057	59084-59097	NN	denotes	concentration
T31058	59097-59098	.	denotes	.
T31059	59098-59166	sentence	denotes	Values obtained for test RNAs were normalized to Hprt1 mRNA levels.
T31060	59099-59105	NNS	denotes	Values
T31061	59106-59114	VBN	denotes	obtained
T31062	59115-59118	IN	denotes	for
T31063	59134-59144	VBN	denotes	normalized
T31064	59119-59123	NN	denotes	test
T31065	59124-59128	NNS	denotes	RNAs
T31066	59129-59133	VBD	denotes	were
T31067	59145-59147	IN	denotes	to
T31068	59148-59153	NN	denotes	Hprt1
T31069	59154-59158	NN	denotes	mRNA
T31070	59159-59165	NNS	denotes	levels
T31071	59165-59166	.	denotes	.
T31605	59249-59251	NN	denotes	BD
T31606	59252-59253	CD	denotes	9
T31588	59168-59175	NNP	denotes	Western
T31589	59176-59181	NNS	denotes	blots
T31590	59181-59182	.	denotes	.
T31591	59182-59310	sentence	denotes	Mouse retinas were homogenized by passing them through a 30-gauge BD 9 http://www.bd.com) needle 5–10 times in 1× PBS solution.
T31592	59183-59188	NN	denotes	Mouse
T31593	59189-59196	NNS	denotes	retinas
T31594	59202-59213	VBN	denotes	homogenized
T31595	59197-59201	VBD	denotes	were
T31596	59214-59216	IN	denotes	by
T31597	59217-59224	VBG	denotes	passing
T31598	59225-59229	PRP	denotes	them
T31599	59230-59237	IN	denotes	through
T31600	59238-59239	DT	denotes	a
T31601	59273-59279	NN	denotes	needle
T31602	59240-59242	CD	denotes	30
T31603	59243-59248	NN	denotes	gauge
T31604	59242-59243	HYPH	denotes	-
T31607	59254-59271	NN	denotes	http://www.bd.com
T31608	59271-59272	-RRB-	denotes	)
T31609	59280-59281	CD	denotes	5
T31610	59282-59284	CD	denotes	10
T31611	59281-59282	SYM	denotes	–
T31612	59285-59290	NNS	denotes	times
T31613	59291-59293	IN	denotes	in
T31614	59294-59295	CD	denotes	1
T31615	59301-59309	NN	denotes	solution
T31616	59295-59296	SYM	denotes	×
T31617	59297-59300	NN	denotes	PBS
T31618	59309-59310	.	denotes	.
T31619	59310-59480	sentence	denotes	Nuclear and cytoplasmic proteins were extracted using the NE-PER Nuclear and Cytoplasmic Extraction Kit (Product# 78833, Pierce Biotechnology, http://www.piercenet.com).
T31620	59311-59318	JJ	denotes	Nuclear
T31621	59335-59343	NN	denotes	proteins
T31622	59319-59322	CC	denotes	and
T31623	59323-59334	JJ	denotes	cytoplasmic
T31624	59349-59358	VBN	denotes	extracted
T31625	59344-59348	VBD	denotes	were
T31626	59359-59364	VBG	denotes	using
T31627	59365-59368	DT	denotes	the
T31628	59411-59414	NN	denotes	Kit
T31629	59369-59371	NN	denotes	NE
T31630	59372-59375	NN	denotes	PER
T31631	59371-59372	HYPH	denotes	-
T31632	59376-59383	JJ	denotes	Nuclear
T31633	59384-59387	CC	denotes	and
T31634	59388-59399	JJ	denotes	Cytoplasmic
T31635	59400-59410	NN	denotes	Extraction
T31636	59415-59416	-LRB-	denotes	(
T31637	59416-59423	NN	denotes	Product
T31638	59423-59424	SYM	denotes	#
T31639	59425-59430	CD	denotes	78833
T31640	59430-59432	,	denotes	,
T31641	59439-59452	NNP	denotes	Biotechnology
T31642	59432-59438	NNP	denotes	Pierce
T31643	59452-59454	,	denotes	,
T31644	59454-59478	NN	denotes	http://www.piercenet.com
T31645	59478-59479	-RRB-	denotes	)
T31646	59479-59480	.	denotes	.
T31647	59480-59555	sentence	denotes	Proteins were separated by 10% SDS-PAGE and transferred to nitrocellulose.
T31648	59481-59489	NNS	denotes	Proteins
T31649	59495-59504	VBN	denotes	separated
T31650	59490-59494	VBD	denotes	were
T31651	59505-59507	IN	denotes	by
T31652	59508-59510	CD	denotes	10
T31653	59510-59511	NN	denotes	%
T31654	59516-59520	NN	denotes	PAGE
T31655	59512-59515	NN	denotes	SDS
T31656	59515-59516	HYPH	denotes	-
T31657	59521-59524	CC	denotes	and
T31658	59525-59536	VBN	denotes	transferred
T31659	59537-59539	IN	denotes	to
T31660	59540-59554	NN	denotes	nitrocellulose
T31661	59554-59555	.	denotes	.
T31662	59555-59683	sentence	denotes	After blocking overnight at 4 °C in 5% skim milk, membranes were incubated in the primary antibody for 2 h at room temperature.
T31663	59556-59561	IN	denotes	After
T31664	59621-59630	VBN	denotes	incubated
T31665	59562-59570	VBG	denotes	blocking
T31666	59571-59580	RB	denotes	overnight
T31667	59581-59583	IN	denotes	at
T31668	59584-59585	CD	denotes	4
T31669	59586-59588	NN	denotes	°C
T31670	59589-59591	IN	denotes	in
T31671	59592-59593	CD	denotes	5
T31672	59593-59594	NN	denotes	%
T31673	59600-59604	NN	denotes	milk
T31674	59595-59599	NN	denotes	skim
T31675	59604-59606	,	denotes	,
T31676	59606-59615	NNS	denotes	membranes
T31677	59616-59620	VBD	denotes	were
T31678	59631-59633	IN	denotes	in
T31679	59634-59637	DT	denotes	the
T31680	59646-59654	NN	denotes	antibody
T31681	59638-59645	JJ	denotes	primary
T31682	59655-59658	IN	denotes	for
T31683	59659-59660	CD	denotes	2
T31684	59661-59662	NN	denotes	h
T31685	59663-59665	IN	denotes	at
T31686	59666-59670	NN	denotes	room
T31687	59671-59682	NN	denotes	temperature
T31688	59682-59683	.	denotes	.
T31689	59683-59963	sentence	denotes	After three 10-min washes in TPBS (100 mM Na2HPO4, 100 mM NaH2PO4, 0.5 N NaCl, 0.1% Tween-20), membranes were incubated for 30 min at room temperature in the secondary horseradish peroxidase-conjugated antibody (Jackson ImmunoResearch Laboratories, http://www.jacksonimmuno.com).
T31690	59684-59689	IN	denotes	After
T31691	59794-59803	VBN	denotes	incubated
T31692	59690-59695	CD	denotes	three
T31693	59703-59709	NNS	denotes	washes
T31694	59696-59698	CD	denotes	10
T31695	59699-59702	NN	denotes	min
T31696	59698-59699	HYPH	denotes	-
T31697	59710-59712	IN	denotes	in
T31698	59713-59717	NN	denotes	TPBS
T31699	59718-59719	-LRB-	denotes	(
T31700	59719-59722	CD	denotes	100
T31701	59723-59725	NN	denotes	mM
T31702	59726-59733	NN	denotes	Na2HPO4
T31703	59733-59735	,	denotes	,
T31704	59735-59738	CD	denotes	100
T31705	59739-59741	NN	denotes	mM
T31706	59742-59749	NN	denotes	NaH2PO4
T31707	59749-59751	,	denotes	,
T31708	59751-59754	CD	denotes	0.5
T31709	59755-59756	NN	denotes	N
T31710	59757-59761	NN	denotes	NaCl
T31711	59761-59763	,	denotes	,
T31712	59763-59766	CD	denotes	0.1
T31713	59766-59767	NN	denotes	%
T31714	59768-59773	NN	denotes	Tween
T31715	59773-59774	HYPH	denotes	-
T31716	59774-59776	CD	denotes	20
T31717	59776-59777	-RRB-	denotes	)
T31718	59777-59779	,	denotes	,
T31719	59779-59788	NNS	denotes	membranes
T31720	59789-59793	VBD	denotes	were
T31721	59804-59807	IN	denotes	for
T31722	59808-59810	CD	denotes	30
T31723	59811-59814	NN	denotes	min
T31724	59815-59817	IN	denotes	at
T31725	59818-59822	NN	denotes	room
T31726	59823-59834	NN	denotes	temperature
T31727	59835-59837	IN	denotes	in
T31728	59838-59841	DT	denotes	the
T31729	59886-59894	NN	denotes	antibody
T31730	59842-59851	JJ	denotes	secondary
T31731	59852-59863	NN	denotes	horseradish
T31732	59864-59874	NN	denotes	peroxidase
T31733	59875-59885	VBN	denotes	conjugated
T31734	59874-59875	HYPH	denotes	-
T31735	59895-59896	-LRB-	denotes	(
T31736	59919-59931	NNP	denotes	Laboratories
T31737	59896-59903	NNP	denotes	Jackson
T31738	59904-59918	NNP	denotes	ImmunoResearch
T31739	59931-59933	,	denotes	,
T31740	59933-59961	NN	denotes	http://www.jacksonimmuno.com
T31741	59961-59962	-RRB-	denotes	)
T31742	59962-59963	.	denotes	.
T31743	59963-60138	sentence	denotes	Blots were developed using the ECL-Plus chemiluminescent detection system (Amersham Pharmacia Biotech, http://www.pharmacia.ca), according to the manufacturer's instructions.
T31744	59964-59969	NNS	denotes	Blots
T31745	59975-59984	VBN	denotes	developed
T31746	59970-59974	VBD	denotes	were
T31747	59985-59990	VBG	denotes	using
T31748	59991-59994	DT	denotes	the
T31749	60031-60037	NN	denotes	system
T31750	59995-59998	NN	denotes	ECL
T31751	59999-60003	NN	denotes	Plus
T31752	59998-59999	HYPH	denotes	-
T31753	60004-60020	JJ	denotes	chemiluminescent
T31754	60021-60030	NN	denotes	detection
T31755	60038-60039	-LRB-	denotes	(
T31756	60058-60065	NNP	denotes	Biotech
T31757	60039-60047	NNP	denotes	Amersham
T31758	60048-60057	NNP	denotes	Pharmacia
T31759	60065-60067	,	denotes	,
T31760	60067-60090	NN	denotes	http://www.pharmacia.ca
T31761	60090-60091	-RRB-	denotes	)
T31762	60091-60093	,	denotes	,
T31763	60093-60102	VBG	denotes	according
T31764	60103-60105	IN	denotes	to
T31765	60106-60109	DT	denotes	the
T31766	60110-60122	NN	denotes	manufacturer
T31767	60125-60137	NNS	denotes	instructions
T31768	60122-60124	POS	denotes	's
T31769	60137-60138	.	denotes	.
T31770	60138-60498	sentence	denotes	The following primary antibodies were used: E2f-1 (SC-193), E2f-3 (SC-878), Cdkn1a (p21, SC-471), Cdkn1b (p27, SC-528), Pou4f2 (Brn3b, SC-6062), and Tfdp1 (Dp1, SC-610) from Santa Cruz Biotechnology (http://www.scbt.com), pRB (554136) from BD Science-Pharmingen (http://www.bdbiosciences.com), and Slc18a3 (VAChT, G448A) from Promega (http://www.promega.com).
T31771	60139-60142	DT	denotes	The
T31772	60161-60171	NNS	denotes	antibodies
T31773	60143-60152	VBG	denotes	following
T31774	60153-60160	JJ	denotes	primary
T31775	60177-60181	VBN	denotes	used
T31776	60172-60176	VBD	denotes	were
T31777	60181-60183	:	denotes	:
T31778	60183-60186	NN	denotes	E2f
T31779	60186-60187	HYPH	denotes	-
T31780	60187-60188	CD	denotes	1
T31781	60189-60190	-LRB-	denotes	(
T31782	60190-60192	NN	denotes	SC
T31783	60192-60193	HYPH	denotes	-
T31784	60193-60196	CD	denotes	193
T31785	60196-60197	-RRB-	denotes	)
T31786	60197-60199	,	denotes	,
T31787	60199-60202	NN	denotes	E2f
T31788	60202-60203	HYPH	denotes	-
T31789	60203-60204	CD	denotes	3
T31790	60205-60206	-LRB-	denotes	(
T31791	60206-60208	NN	denotes	SC
T31792	60208-60209	HYPH	denotes	-
T31793	60209-60212	CD	denotes	878
T31794	60212-60213	-RRB-	denotes	)
T31795	60213-60215	,	denotes	,
T31796	60215-60221	NN	denotes	Cdkn1a
T31797	60222-60223	-LRB-	denotes	(
T31798	60223-60226	NN	denotes	p21
T31799	60226-60228	,	denotes	,
T31800	60228-60230	NN	denotes	SC
T31801	60230-60231	HYPH	denotes	-
T31802	60231-60234	CD	denotes	471
T31803	60234-60235	-RRB-	denotes	)
T31804	60235-60237	,	denotes	,
T31805	60237-60243	NN	denotes	Cdkn1b
T31806	60244-60245	-LRB-	denotes	(
T31807	60245-60248	NN	denotes	p27
T31808	60248-60250	,	denotes	,
T31809	60250-60252	NN	denotes	SC
T31810	60252-60253	HYPH	denotes	-
T31811	60253-60256	CD	denotes	528
T31812	60256-60257	-RRB-	denotes	)
T31813	60257-60259	,	denotes	,
T31814	60259-60265	NN	denotes	Pou4f2
T31815	60266-60267	-LRB-	denotes	(
T31816	60267-60272	NN	denotes	Brn3b
T31817	60272-60274	,	denotes	,
T31818	60274-60276	NN	denotes	SC
T31819	60276-60277	HYPH	denotes	-
T31820	60277-60281	CD	denotes	6062
T31821	60281-60282	-RRB-	denotes	)
T31822	60282-60284	,	denotes	,
T31823	60284-60287	CC	denotes	and
T31824	60288-60293	NN	denotes	Tfdp1
T31825	60294-60295	-LRB-	denotes	(
T31826	60295-60298	NN	denotes	Dp1
T31827	60298-60300	,	denotes	,
T31828	60300-60302	NN	denotes	SC
T31829	60302-60303	HYPH	denotes	-
T31830	60303-60306	CD	denotes	610
T31831	60306-60307	-RRB-	denotes	)
T31832	60308-60312	IN	denotes	from
T31833	60313-60318	NNP	denotes	Santa
T31834	60324-60337	NNP	denotes	Biotechnology
T31835	60319-60323	NNP	denotes	Cruz
T31836	60338-60339	-LRB-	denotes	(
T31837	60339-60358	NN	denotes	http://www.scbt.com
T31838	60358-60359	-RRB-	denotes	)
T31839	60359-60361	,	denotes	,
T31840	60361-60364	NN	denotes	pRB
T31841	60365-60366	-LRB-	denotes	(
T31842	60366-60372	CD	denotes	554136
T31843	60372-60373	-RRB-	denotes	)
T31844	60374-60378	IN	denotes	from
T31845	60379-60381	NNP	denotes	BD
T31846	60390-60400	NNP	denotes	Pharmingen
T31847	60382-60389	NNP	denotes	Science
T31848	60389-60390	HYPH	denotes	-
T31849	60401-60402	-LRB-	denotes	(
T31850	60402-60430	NN	denotes	http://www.bdbiosciences.com
T31851	60430-60431	-RRB-	denotes	)
T31852	60431-60433	,	denotes	,
T31853	60433-60436	CC	denotes	and
T31854	60437-60444	NN	denotes	Slc18a3
T31855	60445-60446	-LRB-	denotes	(
T31856	60446-60451	NN	denotes	VAChT
T31857	60451-60453	,	denotes	,
T31858	60453-60458	NN	denotes	G448A
T31859	60458-60459	-RRB-	denotes	)
T31860	60460-60464	IN	denotes	from
T31861	60465-60472	NNP	denotes	Promega
T31862	60473-60474	-LRB-	denotes	(
T31863	60474-60496	NN	denotes	http://www.promega.com
T31864	60496-60497	-RRB-	denotes	)
T31865	60497-60498	.	denotes	.
T32291	60614-60623	RB	denotes	overnight
T32292	60624-60627	CC	denotes	and
T32266	60500-60519	NN	denotes	Electroretinography
T32267	60519-60520	.	denotes	.
T32268	60520-60581	sentence	denotes	ERGs were recorded from dark-adapted mice as described [72].
T32269	60521-60525	NNS	denotes	ERGs
T32270	60531-60539	VBN	denotes	recorded
T32271	60526-60530	VBD	denotes	were
T32272	60540-60544	IN	denotes	from
T32273	60545-60549	NN	denotes	dark
T32274	60550-60557	VBN	denotes	adapted
T32275	60549-60550	HYPH	denotes	-
T32276	60558-60562	NNS	denotes	mice
T32277	60563-60565	IN	denotes	as
T32278	60566-60575	VBN	denotes	described
T32279	60576-60577	-LRB-	denotes	[
T32280	60577-60579	CD	denotes	72
T32281	60579-60580	-RRB-	denotes	]
T32282	60580-60581	.	denotes	.
T32283	60581-60743	sentence	denotes	Briefly, mice were dark-adapted overnight and anaesthetized by subcutaneous injection of ketamine (66.7 mg/kg body weight) and xylazine (11.7 mg/kg body weight).
T32284	60582-60589	RB	denotes	Briefly
T32285	60606-60613	VBN	denotes	adapted
T32286	60589-60591	,	denotes	,
T32287	60591-60595	NNS	denotes	mice
T32288	60596-60600	VBD	denotes	were
T32289	60601-60605	NN	denotes	dark
T32290	60605-60606	HYPH	denotes	-
T32293	60628-60641	VBN	denotes	anaesthetized
T32294	60642-60644	IN	denotes	by
T32295	60645-60657	JJ	denotes	subcutaneous
T32296	60658-60667	NN	denotes	injection
T32297	60668-60670	IN	denotes	of
T32298	60671-60679	NN	denotes	ketamine
T32299	60680-60681	-LRB-	denotes	(
T32300	60686-60688	NN	denotes	mg
T32301	60681-60685	CD	denotes	66.7
T32302	60688-60689	SYM	denotes	/
T32303	60697-60703	NN	denotes	weight
T32304	60689-60691	NN	denotes	kg
T32305	60692-60696	NN	denotes	body
T32306	60703-60704	-RRB-	denotes	)
T32307	60705-60708	CC	denotes	and
T32308	60709-60717	NN	denotes	xylazine
T32309	60718-60719	-LRB-	denotes	(
T32310	60724-60726	NN	denotes	mg
T32311	60719-60723	CD	denotes	11.7
T32312	60726-60727	SYM	denotes	/
T32313	60735-60741	NN	denotes	weight
T32314	60727-60729	NN	denotes	kg
T32315	60730-60734	NN	denotes	body
T32316	60741-60742	-RRB-	denotes	)
T32317	60742-60743	.	denotes	.
T32318	60743-60884	sentence	denotes	The pupils were dilated and single-flash ERG recordings were obtained under dark-adapted (scotopic) and light-adapted (photopic) conditions.
T32319	60744-60747	DT	denotes	The
T32320	60748-60754	NNS	denotes	pupils
T32321	60760-60767	VBN	denotes	dilated
T32322	60755-60759	VBD	denotes	were
T32323	60768-60771	CC	denotes	and
T32324	60772-60778	JJ	denotes	single
T32325	60779-60784	NN	denotes	flash
T32326	60778-60779	HYPH	denotes	-
T32327	60789-60799	NNS	denotes	recordings
T32328	60785-60788	NN	denotes	ERG
T32329	60805-60813	VBN	denotes	obtained
T32330	60800-60804	VBD	denotes	were
T32331	60814-60819	IN	denotes	under
T32332	60820-60824	NN	denotes	dark
T32333	60825-60832	VBN	denotes	adapted
T32334	60824-60825	HYPH	denotes	-
T32335	60873-60883	NNS	denotes	conditions
T32336	60833-60834	-LRB-	denotes	(
T32337	60834-60842	JJ	denotes	scotopic
T32338	60842-60843	-RRB-	denotes	)
T32339	60844-60847	CC	denotes	and
T32340	60848-60853	NN	denotes	light
T32341	60854-60861	VBN	denotes	adapted
T32342	60853-60854	HYPH	denotes	-
T32343	60862-60863	-LRB-	denotes	(
T32344	60863-60871	JJ	denotes	photopic
T32345	60871-60872	-RRB-	denotes	)
T32346	60883-60884	.	denotes	.
T32347	60884-61019	sentence	denotes	Light adaptation was accomplished with a background illumination of 30 candela (cd) per square meter starting 10 min before recording.
T32348	60885-60890	NN	denotes	Light
T32349	60891-60901	NN	denotes	adaptation
T32350	60906-60918	VBN	denotes	accomplished
T32351	60902-60905	VBD	denotes	was
T32352	60919-60923	IN	denotes	with
T32353	60924-60925	DT	denotes	a
T32354	60937-60949	NN	denotes	illumination
T32355	60926-60936	NN	denotes	background
T32356	60950-60952	IN	denotes	of
T32357	60953-60955	CD	denotes	30
T32358	60956-60963	NN	denotes	candela
T32359	60964-60965	-LRB-	denotes	(
T32360	60965-60967	NN	denotes	cd
T32361	60967-60968	-RRB-	denotes	)
T32362	60969-60972	IN	denotes	per
T32363	60973-60979	JJ	denotes	square
T32364	60980-60985	NN	denotes	meter
T32365	60986-60994	VBG	denotes	starting
T32366	60995-60997	CD	denotes	10
T32367	60998-61001	NN	denotes	min
T32368	61002-61008	IN	denotes	before
T32369	61009-61018	NN	denotes	recording
T32370	61018-61019	.	denotes	.
T32371	61019-61131	sentence	denotes	Single white-flash stimulation ranged from 10−4 to 25 cd·s/m2, divided into ten steps of 0.5 and 1 log cd·s/m2.
T32372	61020-61026	JJ	denotes	Single
T32373	61039-61050	NN	denotes	stimulation
T32374	61027-61032	JJ	denotes	white
T32375	61033-61038	NN	denotes	flash
T32376	61032-61033	HYPH	denotes	-
T32377	61083-61090	VBN	denotes	divided
T32378	61051-61057	VBD	denotes	ranged
T32379	61058-61062	IN	denotes	from
T32380	61063-61065	CD	denotes	10
T32381	61066-61067	CD	denotes	4
T32382	61065-61066	HYPH	denotes	−
T32383	61068-61070	IN	denotes	to
T32384	61071-61073	CD	denotes	25
T32385	61074-61076	NN	denotes	cd
T32386	61077-61078	NN	denotes	s
T32387	61076-61077	SYM	denotes	·
T32388	61078-61079	SYM	denotes	/
T32389	61079-61081	NN	denotes	m2
T32390	61081-61083	,	denotes	,
T32391	61091-61095	IN	denotes	into
T32392	61096-61099	CD	denotes	ten
T32393	61100-61105	NNS	denotes	steps
T32394	61106-61108	IN	denotes	of
T32395	61109-61112	CD	denotes	0.5
T32396	61113-61116	CC	denotes	and
T32397	61117-61118	CD	denotes	1
T32398	61119-61122	NN	denotes	log
T32399	61123-61125	NN	denotes	cd
T32400	61126-61127	NN	denotes	s
T32401	61125-61126	SYM	denotes	·
T32402	61127-61128	SYM	denotes	/
T32403	61128-61130	NN	denotes	m2
T32404	61130-61131	.	denotes	.
T32405	61131-61306	sentence	denotes	Ten responses were averaged with an inter-stimulus interval of either 5 s (for 10−4, 10−3, 10−2, 3 × 10−2, 10−1, and 3 × 10−1 cd·s/m2) or 17 s (for 1, 3, 10, and 25 cd·s/m2).
T32406	61132-61135	CD	denotes	Ten
T32407	61136-61145	NNS	denotes	responses
T32408	61151-61159	VBN	denotes	averaged
T32409	61146-61150	VBD	denotes	were
T32410	61160-61164	IN	denotes	with
T32411	61165-61167	DT	denotes	an
T32412	61183-61191	NN	denotes	interval
T32413	61168-61182	JJ	denotes	inter-stimulus
T32414	61192-61194	IN	denotes	of
T32415	61195-61201	CC	denotes	either
T32416	61204-61205	NN	denotes	s
T32417	61202-61203	CD	denotes	5
T32418	61206-61207	-LRB-	denotes	(
T32419	61207-61210	IN	denotes	for
T32420	61211-61213	CD	denotes	10
T32421	61214-61215	CD	denotes	4
T32422	61213-61214	SYM	denotes	−
T32423	61261-61262	NN	denotes	s
T32424	61215-61217	,	denotes	,
T32425	61217-61219	CD	denotes	10
T32426	61220-61221	CD	denotes	3
T32427	61219-61220	SYM	denotes	−
T32428	61221-61223	,	denotes	,
T32429	61223-61225	CD	denotes	10
T32430	61226-61227	CD	denotes	2
T32431	61225-61226	SYM	denotes	−
T32432	61227-61229	,	denotes	,
T32433	61229-61230	CD	denotes	3
T32434	61236-61237	CD	denotes	2
T32435	61231-61232	SYM	denotes	×
T32436	61233-61235	CD	denotes	10
T32437	61235-61236	SYM	denotes	−
T32438	61237-61239	,	denotes	,
T32439	61239-61241	CD	denotes	10
T32440	61242-61243	CD	denotes	1
T32441	61241-61242	SYM	denotes	−
T32442	61243-61245	,	denotes	,
T32443	61245-61248	CC	denotes	and
T32444	61249-61250	CD	denotes	3
T32445	61256-61257	CD	denotes	1
T32446	61251-61252	SYM	denotes	×
T32447	61253-61255	CD	denotes	10
T32448	61255-61256	SYM	denotes	−
T32449	61258-61260	NN	denotes	cd
T32450	61260-61261	SYM	denotes	·
T32451	61262-61263	SYM	denotes	/
T32452	61263-61265	NN	denotes	m2
T32453	61265-61266	-RRB-	denotes	)
T32454	61267-61269	CC	denotes	or
T32455	61270-61272	CD	denotes	17
T32456	61273-61274	NN	denotes	s
T32457	61275-61276	-LRB-	denotes	(
T32458	61276-61279	IN	denotes	for
T32459	61280-61281	CD	denotes	1
T32460	61300-61301	NN	denotes	s
T32461	61281-61283	,	denotes	,
T32462	61283-61284	CD	denotes	3
T32463	61284-61286	,	denotes	,
T32464	61286-61288	CD	denotes	10
T32465	61288-61290	,	denotes	,
T32466	61290-61293	CC	denotes	and
T32467	61294-61296	CD	denotes	25
T32468	61297-61299	NN	denotes	cd
T32469	61299-61300	SYM	denotes	·
T32470	61301-61302	SYM	denotes	/
T32471	61302-61304	NN	denotes	m2
T32472	61304-61305	-RRB-	denotes	)
T32473	61305-61306	.	denotes	.
T32474	61306-61366	sentence	denotes	Band-pass filter cut-off frequencies were 0.1 and 3,000 Hz.
T32475	61307-61311	NN	denotes	Band
T32476	61312-61316	NN	denotes	pass
T32477	61311-61312	HYPH	denotes	-
T32478	61317-61323	NN	denotes	filter
T32479	61332-61343	NNS	denotes	frequencies
T32480	61324-61327	VB	denotes	cut
T32481	61327-61328	HYPH	denotes	-
T32482	61328-61331	RP	denotes	off
T32483	61344-61348	VBD	denotes	were
T32484	61349-61352	CD	denotes	0.1
T32485	61363-61365	NN	denotes	Hz
T32486	61353-61356	CC	denotes	and
T32487	61357-61362	CD	denotes	3,000
T32488	61365-61366	.	denotes	.
T32571	61466-61471	NNP	denotes	Tukey
T32572	61493-61503	NN	denotes	difference
T32573	61472-61480	RB	denotes	honestly
T32574	61481-61492	JJ	denotes	significant
T32575	61504-61505	-LRB-	denotes	(
T32576	61505-61508	NN	denotes	HSD
T32577	61508-61509	-RRB-	denotes	)
T32578	61515-61517	CC	denotes	or
T32579	61518-61524	NNP	denotes	Fisher
T32580	61525-61529	NN	denotes	test
T32581	61530-61531	-LRB-	denotes	(
T32582	61538-61545	NN	denotes	program
T32583	61531-61537	NNP	denotes	XLSTAT
T32584	61545-61547	,	denotes	,
T32585	61547-61568	NN	denotes	http://www.xlstat.com
T32586	61568-61569	-RRB-	denotes	)
T32587	61569-61570	.	denotes	.
T33426	4237-4241	NN	denotes	E2f1
T33427	4265-4269	NN	denotes	Loss
T33428	4241-4243	,	denotes	,
T33429	4243-4246	CC	denotes	but
T33430	4247-4250	RB	denotes	Not
T33431	4251-4255	NN	denotes	E2f2
T33432	4256-4258	CC	denotes	or
T33433	4259-4263	NN	denotes	E2f3
T33434	4263-4265	,	denotes	,
T33435	4270-4277	VBZ	denotes	Rescues
T33436	4278-4285	JJ	denotes	Ectopic
T33437	4286-4294	NN	denotes	Division
T33438	4295-4298	CC	denotes	and
T33439	4299-4303	NN	denotes	Cell
T33440	4304-4309	NN	denotes	Death
T33441	4310-4312	IN	denotes	in
T33442	4313-4316	DT	denotes	the
T33443	4323-4329	NN	denotes	Retina
T33444	4317-4319	NN	denotes	Rb
T33445	4320-4322	NN	denotes	KO
T33446	4329-4354	sentence	denotes	(A) Retinal development.
T33447	4330-4331	-LRB-	denotes	(
T33448	4331-4332	LS	denotes	A
T33449	4342-4353	NN	denotes	development
T33450	4332-4333	-RRB-	denotes	)
T33451	4334-4341	JJ	denotes	Retinal
T33452	4353-4354	.	denotes	.
T33453	4354-4428	sentence	denotes	At E11 the retina is a NBL of dividing RPCs (white circle, green nuclei).
T33454	4355-4357	IN	denotes	At
T33455	4373-4375	VBZ	denotes	is
T33456	4358-4361	NN	denotes	E11
T33457	4362-4365	DT	denotes	the
T33458	4366-4372	NN	denotes	retina
T33459	4376-4377	DT	denotes	a
T33460	4378-4381	NN	denotes	NBL
T33461	4382-4384	IN	denotes	of
T33462	4385-4393	VBG	denotes	dividing
T33463	4394-4398	NNS	denotes	RPCs
T33464	4399-4400	-LRB-	denotes	(
T33465	4420-4426	NNS	denotes	nuclei
T33466	4400-4405	JJ	denotes	white
T33467	4406-4412	NN	denotes	circle
T33468	4412-4414	,	denotes	,
T33469	4414-4419	JJ	denotes	green
T33470	4426-4427	-RRB-	denotes	)
T33471	4427-4428	.	denotes	.
T33472	4428-4511	sentence	denotes	RPC cell bodies oscillate along processes as they progress through the cell cycle.
T33473	4429-4432	NN	denotes	RPC
T33474	4438-4444	NNS	denotes	bodies
T33475	4433-4437	NN	denotes	cell
T33476	4445-4454	VBP	denotes	oscillate
T33477	4455-4460	IN	denotes	along
T33478	4461-4470	NNS	denotes	processes
T33479	4471-4473	IN	denotes	as
T33480	4479-4487	VBP	denotes	progress
T33481	4474-4478	PRP	denotes	they
T33482	4488-4495	IN	denotes	through
T33483	4496-4499	DT	denotes	the
T33484	4505-4510	NN	denotes	cycle
T33485	4500-4504	NN	denotes	cell
T33486	4510-4511	.	denotes	.
T33487	4511-4639	sentence	denotes	By P0 the NBL contains both RPCs and post-mitotic RTCs (coloured circles, red nuclei) and is separated from the GCL by the IPL.
T33488	4512-4514	IN	denotes	By
T33489	4526-4534	VBZ	denotes	contains
T33490	4515-4517	NN	denotes	P0
T33491	4518-4521	DT	denotes	the
T33492	4522-4525	NN	denotes	NBL
T33493	4535-4539	CC	denotes	both
T33494	4540-4544	NNS	denotes	RPCs
T33495	4545-4548	CC	denotes	and
T33496	4549-4561	JJ	denotes	post-mitotic
T33497	4562-4566	NNS	denotes	RTCs
T33498	4567-4568	-LRB-	denotes	(
T33499	4590-4596	NNS	denotes	nuclei
T33500	4568-4576	VBN	denotes	coloured
T33501	4577-4584	NNS	denotes	circles
T33502	4584-4586	,	denotes	,
T33503	4586-4589	JJ	denotes	red
T33504	4596-4597	-RRB-	denotes	)
T33505	4598-4601	CC	denotes	and
T33506	4602-4604	VBZ	denotes	is
T33507	4605-4614	VBN	denotes	separated
T33508	4615-4619	IN	denotes	from
T33509	4620-4623	DT	denotes	the
T33510	4624-4627	NN	denotes	GCL
T33511	4628-4630	IN	denotes	by
T33512	4631-4634	DT	denotes	the
T33513	4635-4638	NN	denotes	IPL
T33514	4638-4639	.	denotes	.
T33515	4639-4877	sentence	denotes	By P8 there are no RPCs, fewer RTCs, an OPL, and more differentiated rods (r) and cones (c) in the ONL; horizontal (h), bipolar (b), Müller (m), and amacrine (a) cells in the INL; and ganglion (g) and displaced amacrine cells in the GCL.
T33516	4640-4642	IN	denotes	By
T33517	4652-4655	VBP	denotes	are
T33518	4643-4645	NN	denotes	P8
T33519	4646-4651	EX	denotes	there
T33520	4656-4658	DT	denotes	no
T33521	4659-4663	NNS	denotes	RPCs
T33522	4663-4665	,	denotes	,
T33523	4665-4670	JJR	denotes	fewer
T33524	4671-4675	NNS	denotes	RTCs
T33525	4675-4677	,	denotes	,
T33526	4677-4679	DT	denotes	an
T33527	4680-4683	NN	denotes	OPL
T33528	4683-4685	,	denotes	,
T33529	4685-4688	CC	denotes	and
T33530	4689-4693	JJR	denotes	more
T33531	4709-4713	NNS	denotes	rods
T33532	4694-4708	VBN	denotes	differentiated
T33533	4714-4715	-LRB-	denotes	(
T33534	4715-4716	NN	denotes	r
T33535	4716-4717	-RRB-	denotes	)
T33536	4718-4721	CC	denotes	and
T33537	4722-4727	NNS	denotes	cones
T33538	4728-4729	-LRB-	denotes	(
T33539	4729-4730	NN	denotes	c
T33540	4730-4731	-RRB-	denotes	)
T33541	4732-4734	IN	denotes	in
T33542	4735-4738	DT	denotes	the
T33543	4739-4742	NN	denotes	ONL
T33544	4742-4743	:	denotes	;
T33545	4744-4754	JJ	denotes	horizontal
T33546	4802-4807	NNS	denotes	cells
T33547	4755-4756	-LRB-	denotes	(
T33548	4756-4757	NN	denotes	h
T33549	4757-4758	-RRB-	denotes	)
T33550	4758-4760	,	denotes	,
T33551	4760-4767	JJ	denotes	bipolar
T33552	4768-4769	-LRB-	denotes	(
T33553	4769-4770	NN	denotes	b
T33554	4770-4771	-RRB-	denotes	)
T33555	4771-4773	,	denotes	,
T33556	4773-4779	NN	denotes	Müller
T33557	4780-4781	-LRB-	denotes	(
T33558	4781-4782	NN	denotes	m
T33559	4782-4783	-RRB-	denotes	)
T33560	4783-4785	,	denotes	,
T33561	4785-4788	CC	denotes	and
T33562	4789-4797	JJ	denotes	amacrine
T33563	4798-4799	-LRB-	denotes	(
T33564	4799-4800	JJ	denotes	a
T33565	4800-4801	-RRB-	denotes	)
T33566	4808-4810	IN	denotes	in
T33567	4811-4814	DT	denotes	the
T33568	4815-4818	NN	denotes	INL
T33569	4818-4819	:	denotes	;
T33570	4820-4823	CC	denotes	and
T33571	4824-4832	NN	denotes	ganglion
T33572	4833-4834	-LRB-	denotes	(
T33573	4834-4835	NN	denotes	g
T33574	4835-4836	-RRB-	denotes	)
T33575	4837-4840	CC	denotes	and
T33576	4841-4850	VBN	denotes	displaced
T33577	4851-4859	JJ	denotes	amacrine
T33578	4860-4865	NNS	denotes	cells
T33579	4866-4868	IN	denotes	in
T33580	4869-4872	DT	denotes	the
T33581	4873-4876	NN	denotes	GCL
T33582	4876-4877	.	denotes	.
T33583	4877-4910	sentence	denotes	Development is complete by ~P18.
T33584	4878-4889	NN	denotes	Development
T33585	4890-4892	VBZ	denotes	is
T33586	4893-4901	JJ	denotes	complete
T33587	4902-4904	IN	denotes	by
T33588	4905-4906	SYM	denotes	~
T33589	4906-4909	NN	denotes	P18
T33590	4909-4910	.	denotes	.
T33591	4910-5071	sentence	denotes	(B) Rb is thought to regulate cell cycle and apoptosis by repressing E2fs, but to promote differentiation by potentiating tissue-specific transcription factors.
T33592	4911-4912	-LRB-	denotes	(
T33593	4912-4913	LS	denotes	B
T33594	4921-4928	VBN	denotes	thought
T33595	4913-4914	-RRB-	denotes	)
T33596	4915-4917	NN	denotes	Rb
T33597	4918-4920	VBZ	denotes	is
T33598	4929-4931	TO	denotes	to
T33599	4932-4940	VB	denotes	regulate
T33600	4941-4945	NN	denotes	cell
T33601	4946-4951	NN	denotes	cycle
T33602	4952-4955	CC	denotes	and
T33603	4956-4965	NN	denotes	apoptosis
T33604	4966-4968	IN	denotes	by
T33605	4969-4979	VBG	denotes	repressing
T33606	4980-4984	NNS	denotes	E2fs
T33607	4984-4986	,	denotes	,
T33608	4986-4989	CC	denotes	but
T33609	4990-4992	TO	denotes	to
T33610	4993-5000	VB	denotes	promote
T33611	5001-5016	NN	denotes	differentiation
T33612	5017-5019	IN	denotes	by
T33613	5020-5032	VBG	denotes	potentiating
T33614	5033-5039	NN	denotes	tissue
T33615	5040-5048	JJ	denotes	specific
T33616	5039-5040	HYPH	denotes	-
T33617	5063-5070	NNS	denotes	factors
T33618	5049-5062	NN	denotes	transcription
T33619	5070-5071	.	denotes	.
T33620	5071-5250	sentence	denotes	However, Rb loss could also perturb differentiation through the indirect effects of abnormal division or death, and/or through direct regulation of differentiation genes by E2fs.
T33621	5072-5079	RB	denotes	However
T33622	5100-5107	VB	denotes	perturb
T33623	5079-5081	,	denotes	,
T33624	5081-5083	NN	denotes	Rb
T33625	5084-5088	NN	denotes	loss
T33626	5089-5094	MD	denotes	could
T33627	5095-5099	RB	denotes	also
T33628	5108-5123	NN	denotes	differentiation
T33629	5124-5131	IN	denotes	through
T33630	5132-5135	DT	denotes	the
T33631	5145-5152	NNS	denotes	effects
T33632	5136-5144	JJ	denotes	indirect
T33633	5153-5155	IN	denotes	of
T33634	5156-5164	JJ	denotes	abnormal
T33635	5165-5173	NN	denotes	division
T33636	5174-5176	CC	denotes	or
T33637	5177-5182	NN	denotes	death
T33638	5182-5184	,	denotes	,
T33639	5184-5187	CC	denotes	and
T33640	5187-5188	HYPH	denotes	/
T33641	5188-5190	CC	denotes	or
T33642	5191-5198	IN	denotes	through
T33643	5199-5205	JJ	denotes	direct
T33644	5206-5216	NN	denotes	regulation
T33645	5217-5219	IN	denotes	of
T33646	5220-5235	NN	denotes	differentiation
T33647	5236-5241	NNS	denotes	genes
T33648	5242-5244	IN	denotes	by
T33649	5245-5249	NNS	denotes	E2fs
T33650	5249-5250	.	denotes	.
T33651	5250-5426	sentence	denotes	(C and D) Horizontal retinal sections of the indicated genotypes and ages were stained for nuclei (DAPI, blue), and (C) S-phase (anti-BrdU, red) or (D) apoptosis (TUNEL, red).
T33652	5251-5252	-LRB-	denotes	(
T33653	5252-5253	LS	denotes	C
T33654	5330-5337	VBN	denotes	stained
T33655	5254-5257	CC	denotes	and
T33656	5258-5259	LS	denotes	D
T33657	5259-5260	-RRB-	denotes	)
T33658	5261-5271	JJ	denotes	Horizontal
T33659	5280-5288	NNS	denotes	sections
T33660	5272-5279	JJ	denotes	retinal
T33661	5289-5291	IN	denotes	of
T33662	5292-5295	DT	denotes	the
T33663	5306-5315	NNS	denotes	genotypes
T33664	5296-5305	VBN	denotes	indicated
T33665	5316-5319	CC	denotes	and
T33666	5320-5324	NNS	denotes	ages
T33667	5325-5329	VBD	denotes	were
T33668	5338-5341	IN	denotes	for
T33669	5342-5348	NNS	denotes	nuclei
T33670	5349-5350	-LRB-	denotes	(
T33671	5356-5360	JJ	denotes	blue
T33672	5350-5354	NN	denotes	DAPI
T33673	5354-5356	,	denotes	,
T33674	5360-5361	-RRB-	denotes	)
T33675	5361-5363	,	denotes	,
T33676	5363-5366	CC	denotes	and
T33677	5367-5368	-LRB-	denotes	(
T33678	5368-5369	NN	denotes	C
T33679	5373-5378	NN	denotes	phase
T33680	5369-5370	-RRB-	denotes	)
T33681	5371-5372	NN	denotes	S
T33682	5372-5373	HYPH	denotes	-
T33683	5379-5380	-LRB-	denotes	(
T33684	5391-5394	JJ	denotes	red
T33685	5380-5389	JJ	denotes	anti-BrdU
T33686	5389-5391	,	denotes	,
T33687	5394-5395	-RRB-	denotes	)
T33688	5396-5398	CC	denotes	or
T33689	5399-5400	-LRB-	denotes	(
T33690	5400-5401	NN	denotes	D
T33691	5403-5412	NN	denotes	apoptosis
T33692	5401-5402	-RRB-	denotes	)
T33693	5413-5414	-LRB-	denotes	(
T33694	5421-5424	JJ	denotes	red
T33695	5414-5419	NN	denotes	TUNEL
T33696	5419-5421	,	denotes	,
T33697	5424-5425	-RRB-	denotes	)
T33698	5425-5426	.	denotes	.
T33699	5426-5448	sentence	denotes	Scale bars are 50 μm.
T33700	5427-5432	NN	denotes	Scale
T33701	5433-5437	NNS	denotes	bars
T33702	5438-5441	VBP	denotes	are
T33703	5442-5444	CD	denotes	50
T33704	5445-5447	NN	denotes	μm
T33705	5447-5448	.	denotes	.
T33706	5448-5559	sentence	denotes	(E–G) Quantification of (E) all BrdU+ cells, (F) ectopic BrdU+ cells in GCL at P0, and (G) total TUNEL+ cells.
T33707	5449-5450	-LRB-	denotes	(
T33708	5450-5451	LS	denotes	E
T33709	5455-5469	NN	denotes	Quantification
T33710	5451-5452	SYM	denotes	–
T33711	5452-5453	LS	denotes	G
T33712	5453-5454	-RRB-	denotes	)
T33713	5470-5472	IN	denotes	of
T33714	5473-5474	-LRB-	denotes	(
T33715	5474-5475	NN	denotes	E
T33716	5487-5492	NNS	denotes	cells
T33717	5475-5476	-RRB-	denotes	)
T33718	5477-5480	DT	denotes	all
T33719	5481-5485	NN	denotes	BrdU
T33720	5485-5486	SYM	denotes	+
T33721	5492-5494	,	denotes	,
T33722	5494-5495	-LRB-	denotes	(
T33723	5495-5496	NN	denotes	F
T33724	5512-5517	NNS	denotes	cells
T33725	5496-5497	-RRB-	denotes	)
T33726	5498-5505	JJ	denotes	ectopic
T33727	5506-5510	NN	denotes	BrdU
T33728	5510-5511	SYM	denotes	+
T33729	5518-5520	IN	denotes	in
T33730	5521-5524	NN	denotes	GCL
T33731	5525-5527	IN	denotes	at
T33732	5528-5530	NN	denotes	P0
T33733	5530-5532	,	denotes	,
T33734	5532-5535	CC	denotes	and
T33735	5536-5537	-LRB-	denotes	(
T33736	5537-5538	NN	denotes	G
T33737	5553-5558	NNS	denotes	cells
T33738	5538-5539	-RRB-	denotes	)
T33739	5540-5545	JJ	denotes	total
T33740	5546-5551	NN	denotes	TUNEL
T33741	5551-5552	SYM	denotes	+
T33742	5558-5559	.	denotes	.
T33743	5559-5660	sentence	denotes	(H) Real-time RT-PCR analysis of E2fs and E2f target genes in P8 retinas of the indicated genotypes.
T33744	5560-5561	-LRB-	denotes	(
T33745	5561-5562	LS	denotes	H
T33746	5581-5589	NN	denotes	analysis
T33747	5562-5563	-RRB-	denotes	)
T33748	5564-5568	JJ	denotes	Real
T33749	5569-5573	NN	denotes	time
T33750	5568-5569	HYPH	denotes	-
T33751	5577-5580	NN	denotes	PCR
T33752	5574-5576	NN	denotes	RT
T33753	5576-5577	HYPH	denotes	-
T33754	5590-5592	IN	denotes	of
T33755	5593-5597	NNS	denotes	E2fs
T33756	5598-5601	CC	denotes	and
T33757	5602-5605	NN	denotes	E2f
T33758	5613-5618	NNS	denotes	genes
T33759	5606-5612	NN	denotes	target
T33760	5619-5621	IN	denotes	in
T33761	5622-5624	NN	denotes	P8
T33762	5625-5632	NNS	denotes	retinas
T33763	5633-5635	IN	denotes	of
T33764	5636-5639	DT	denotes	the
T33765	5650-5659	NNS	denotes	genotypes
T33766	5640-5649	VBN	denotes	indicated
T33767	5659-5660	.	denotes	.
T33768	5660-5894	sentence	denotes	Error bars represent SD of measurements from three animals, and asterisks indicate a significant difference between the WT and indicated genotypes (, p <0.05; *; p <0.01; ANOVA and Tukey HSD test for [E–G] and Fisher test for [H]).
T33769	5661-5666	NN	denotes	Error
T33770	5667-5671	NNS	denotes	bars
T33771	5672-5681	VBP	denotes	represent
T33772	5682-5684	NN	denotes	SD
T33773	5685-5687	IN	denotes	of
T33774	5688-5700	NNS	denotes	measurements
T33775	5701-5705	IN	denotes	from
T33776	5706-5711	CD	denotes	three
T33777	5712-5719	NNS	denotes	animals
T33778	5719-5721	,	denotes	,
T33779	5721-5724	CC	denotes	and
T33780	5725-5734	NNS	denotes	asterisks
T33781	5735-5743	VBP	denotes	indicate
T33782	5744-5745	DT	denotes	a
T33783	5758-5768	NN	denotes	difference
T33784	5746-5757	JJ	denotes	significant
T33785	5769-5776	IN	denotes	between
T33786	5777-5780	DT	denotes	the
T33787	5798-5807	NNS	denotes	genotypes
T33788	5781-5783	NN	denotes	WT
T33789	5784-5787	CC	denotes	and
T33790	5788-5797	VBN	denotes	indicated
T33791	5808-5809	-LRB-	denotes	(
T33792	5854-5858	NN	denotes	test
T33793	5809-5810	SYM	denotes	*
T33794	5815-5819	CD	denotes	0.05
T33795	5810-5812	,	denotes	,
T33796	5812-5813	NN	denotes	p
T33797	5814-5815	SYM	denotes	<
T33798	5819-5820	:	denotes	;
T33799	5821-5823	SYM	denotes	**
T33800	5828-5832	CD	denotes	0.01
T33801	5823-5824	:	denotes	;
T33802	5825-5826	NN	denotes	p
T33803	5827-5828	SYM	denotes	<
T33804	5832-5833	:	denotes	;
T33805	5834-5839	NN	denotes	ANOVA
T33806	5840-5843	CC	denotes	and
T33807	5844-5849	NNP	denotes	Tukey
T33808	5850-5853	NN	denotes	HSD
T33809	5859-5862	IN	denotes	for
T33810	5863-5864	-LRB-	denotes	[
T33811	5864-5865	NN	denotes	E
T33812	5865-5866	SYM	denotes	–
T33813	5866-5867	NN	denotes	G
T33814	5867-5868	-RRB-	denotes	]
T33815	5869-5872	CC	denotes	and
T33816	5873-5879	NNP	denotes	Fisher
T33817	5880-5884	NN	denotes	test
T33818	5885-5888	IN	denotes	for
T33819	5889-5890	-LRB-	denotes	[
T33820	5890-5891	NN	denotes	H
T33821	5891-5892	-RRB-	denotes	]
T33822	5892-5893	-RRB-	denotes	)
T33823	5893-5894	.	denotes	.
T34466	14870-14872	,	denotes	,
T34416	14628-14632	NN	denotes	E2f1
T34417	14633-14641	NN	denotes	Deletion
T34418	14642-14649	VBZ	denotes	Rescues
T34419	14650-14658	NN	denotes	Ganglion
T34420	14677-14682	NNS	denotes	Cells
T34421	14658-14660	,	denotes	,
T34422	14660-14663	NN	denotes	Rod
T34423	14663-14665	,	denotes	,
T34424	14665-14668	CC	denotes	and
T34425	14669-14676	JJ	denotes	Bipolar
T34426	14683-14685	IN	denotes	in
T34427	14686-14689	DT	denotes	the
T34428	14696-14702	NN	denotes	Retina
T34429	14690-14692	NN	denotes	Rb
T34430	14693-14695	NN	denotes	KO
T34431	14702-14969	sentence	denotes	(A) Horizontal retinal sections from mice of the indicated ages and genotypes were stained for nuclei (DAPI, blue) and markers that detect ganglion cells (Pou4f2, red), rods and cones (Sag [rod arrestin], green), and rod bipolar cells (Prkca, green, and Cabp5, red).
T34432	14703-14704	-LRB-	denotes	(
T34433	14704-14705	LS	denotes	A
T34434	14786-14793	VBN	denotes	stained
T34435	14705-14706	-RRB-	denotes	)
T34436	14707-14717	JJ	denotes	Horizontal
T34437	14726-14734	NNS	denotes	sections
T34438	14718-14725	JJ	denotes	retinal
T34439	14735-14739	IN	denotes	from
T34440	14740-14744	NNS	denotes	mice
T34441	14745-14747	IN	denotes	of
T34442	14748-14751	DT	denotes	the
T34443	14762-14766	NNS	denotes	ages
T34444	14752-14761	VBN	denotes	indicated
T34445	14767-14770	CC	denotes	and
T34446	14771-14780	NNS	denotes	genotypes
T34447	14781-14785	VBD	denotes	were
T34448	14794-14797	IN	denotes	for
T34449	14798-14804	NNS	denotes	nuclei
T34450	14805-14806	-LRB-	denotes	(
T34451	14812-14816	JJ	denotes	blue
T34452	14806-14810	NN	denotes	DAPI
T34453	14810-14812	,	denotes	,
T34454	14816-14817	-RRB-	denotes	)
T34455	14818-14821	CC	denotes	and
T34456	14822-14829	NNS	denotes	markers
T34457	14830-14834	WDT	denotes	that
T34458	14835-14841	VBP	denotes	detect
T34459	14842-14850	NN	denotes	ganglion
T34460	14851-14856	NNS	denotes	cells
T34461	14857-14858	-LRB-	denotes	(
T34462	14866-14869	JJ	denotes	red
T34463	14858-14864	NN	denotes	Pou4f2
T34464	14864-14866	,	denotes	,
T34465	14869-14870	-RRB-	denotes	)
T34467	14872-14876	NNS	denotes	rods
T34468	14877-14880	CC	denotes	and
T34469	14881-14886	NNS	denotes	cones
T34470	14887-14888	-LRB-	denotes	(
T34471	14908-14913	JJ	denotes	green
T34472	14888-14891	NN	denotes	Sag
T34473	14892-14893	-LRB-	denotes	[
T34474	14893-14896	NN	denotes	rod
T34475	14897-14905	NN	denotes	arrestin
T34476	14905-14906	-RRB-	denotes	]
T34477	14906-14908	,	denotes	,
T34478	14913-14914	-RRB-	denotes	)
T34479	14914-14916	,	denotes	,
T34480	14916-14919	CC	denotes	and
T34481	14920-14923	NN	denotes	rod
T34482	14932-14937	NNS	denotes	cells
T34483	14924-14931	JJ	denotes	bipolar
T34484	14938-14939	-LRB-	denotes	(
T34485	14946-14951	JJ	denotes	green
T34486	14939-14944	NN	denotes	Prkca
T34487	14944-14946	,	denotes	,
T34488	14951-14953	,	denotes	,
T34489	14953-14956	CC	denotes	and
T34490	14957-14962	NN	denotes	Cabp5
T34491	14964-14967	JJ	denotes	red
T34492	14962-14964	,	denotes	,
T34493	14967-14968	-RRB-	denotes	)
T34494	14968-14969	.	denotes	.
T34495	14969-14991	sentence	denotes	Scale bars are 50 μm.
T34496	14970-14975	NN	denotes	Scale
T34497	14976-14980	NNS	denotes	bars
T34498	14981-14984	VBP	denotes	are
T34499	14985-14987	CD	denotes	50
T34500	14988-14990	NN	denotes	μm
T34501	14990-14991	.	denotes	.
T34502	14991-15037	sentence	denotes	(B) Quantification of Pou4f2+ ganglion cells.
T34503	14992-14993	-LRB-	denotes	(
T34504	14993-14994	LS	denotes	B
T34505	14996-15010	NN	denotes	Quantification
T34506	14994-14995	-RRB-	denotes	)
T34507	15011-15013	IN	denotes	of
T34508	15014-15020	NN	denotes	Pou4f2
T34509	15031-15036	NNS	denotes	cells
T34510	15020-15021	SYM	denotes	+
T34511	15022-15030	NN	denotes	ganglion
T34512	15036-15037	.	denotes	.
T34513	15037-15092	sentence	denotes	(C) Quantification of Prkca+ and Cabp5+ bipolar cells.
T34514	15038-15039	-LRB-	denotes	(
T34515	15039-15040	LS	denotes	C
T34516	15042-15056	NN	denotes	Quantification
T34517	15040-15041	-RRB-	denotes	)
T34518	15057-15059	IN	denotes	of
T34519	15060-15065	NN	denotes	Prkca
T34520	15086-15091	NNS	denotes	cells
T34521	15065-15066	SYM	denotes	+
T34522	15067-15070	CC	denotes	and
T34523	15071-15076	NN	denotes	Cabp5
T34524	15076-15077	SYM	denotes	+
T34525	15078-15085	JJ	denotes	bipolar
T34526	15091-15092	.	denotes	.
T34527	15092-15155	sentence	denotes	(D) Thickness of the ONL, which represents the number of rods.
T34528	15093-15094	-LRB-	denotes	(
T34529	15094-15095	LS	denotes	D
T34530	15097-15106	NN	denotes	Thickness
T34531	15095-15096	-RRB-	denotes	)
T34532	15107-15109	IN	denotes	of
T34533	15110-15113	DT	denotes	the
T34534	15114-15117	NN	denotes	ONL
T34535	15117-15119	,	denotes	,
T34536	15119-15124	WDT	denotes	which
T34537	15125-15135	VBZ	denotes	represents
T34538	15136-15139	DT	denotes	the
T34539	15140-15146	NN	denotes	number
T34540	15147-15149	IN	denotes	of
T34541	15150-15154	NNS	denotes	rods
T34542	15154-15155	.	denotes	.
T34543	15155-15416	sentence	denotes	Error bars represent SD of measurements from three animals, and asterisks indicate a significant difference between retinas of WT and the indicated genotypes, unless indicated otherwise by connecting lines (, p < 0.05; *; p < 0.01; ANOVA and Tukey HSD test).
T34544	15156-15161	NN	denotes	Error
T34545	15162-15166	NNS	denotes	bars
T34546	15167-15176	VBP	denotes	represent
T34547	15177-15179	NN	denotes	SD
T34548	15180-15182	IN	denotes	of
T34549	15183-15195	NNS	denotes	measurements
T34550	15196-15200	IN	denotes	from
T34551	15201-15206	CD	denotes	three
T34552	15207-15214	NNS	denotes	animals
T34553	15214-15216	,	denotes	,
T34554	15216-15219	CC	denotes	and
T34555	15220-15229	NNS	denotes	asterisks
T34556	15230-15238	VBP	denotes	indicate
T34557	15239-15240	DT	denotes	a
T34558	15253-15263	NN	denotes	difference
T34559	15241-15252	JJ	denotes	significant
T34560	15264-15271	IN	denotes	between
T34561	15272-15279	NNS	denotes	retinas
T34562	15280-15282	IN	denotes	of
T34563	15283-15285	NN	denotes	WT
T34564	15286-15289	CC	denotes	and
T34565	15290-15293	DT	denotes	the
T34566	15294-15303	VBN	denotes	indicated
T34567	15304-15313	NNS	denotes	genotypes
T34568	15313-15315	,	denotes	,
T34569	15315-15321	IN	denotes	unless
T34570	15322-15331	VBN	denotes	indicated
T34571	15332-15341	RB	denotes	otherwise
T34572	15342-15344	IN	denotes	by
T34573	15345-15355	VBG	denotes	connecting
T34574	15356-15361	NNS	denotes	lines
T34575	15362-15363	-LRB-	denotes	(
T34576	15410-15414	NN	denotes	test
T34577	15363-15364	SYM	denotes	*
T34578	15370-15374	CD	denotes	0.05
T34579	15364-15366	,	denotes	,
T34580	15366-15367	NN	denotes	p
T34581	15368-15369	SYM	denotes	<
T34582	15374-15375	:	denotes	;
T34583	15376-15378	SYM	denotes	**
T34584	15384-15388	CD	denotes	0.01
T34585	15378-15379	:	denotes	;
T34586	15380-15381	NN	denotes	p
T34587	15382-15383	SYM	denotes	<
T34588	15388-15389	:	denotes	;
T34589	15390-15395	NN	denotes	ANOVA
T34590	15396-15399	CC	denotes	and
T34591	15400-15405	NNP	denotes	Tukey
T34592	15406-15409	NN	denotes	HSD
T34593	15414-15415	-RRB-	denotes	)
T34594	15415-15416	.	denotes	.
T34595	15416-15638	sentence	denotes	(E and F) ERGs were recorded from the indicated genotypes under dark-adapted (scotopic) conditions, and (E) intensity series and (F) b-wave amplitudes as a function of the logarithm of the flash intensity were determined.
T34596	15417-15418	-LRB-	denotes	(
T34597	15418-15419	LS	denotes	E
T34598	15437-15445	VBN	denotes	recorded
T34599	15420-15423	CC	denotes	and
T34600	15424-15425	LS	denotes	F
T34601	15425-15426	-RRB-	denotes	)
T34602	15427-15431	NNS	denotes	ERGs
T34603	15432-15436	VBD	denotes	were
T34604	15446-15450	IN	denotes	from
T34605	15451-15454	DT	denotes	the
T34606	15465-15474	NNS	denotes	genotypes
T34607	15455-15464	VBN	denotes	indicated
T34608	15475-15480	IN	denotes	under
T34609	15481-15485	NN	denotes	dark
T34610	15486-15493	VBN	denotes	adapted
T34611	15485-15486	HYPH	denotes	-
T34612	15505-15515	NNS	denotes	conditions
T34613	15494-15495	-LRB-	denotes	(
T34614	15495-15503	JJ	denotes	scotopic
T34615	15503-15504	-RRB-	denotes	)
T34616	15515-15517	,	denotes	,
T34617	15517-15520	CC	denotes	and
T34618	15521-15522	-LRB-	denotes	(
T34619	15522-15523	NN	denotes	E
T34620	15535-15541	NN	denotes	series
T34621	15523-15524	-RRB-	denotes	)
T34622	15525-15534	NN	denotes	intensity
T34623	15627-15637	VBN	denotes	determined
T34624	15542-15545	CC	denotes	and
T34625	15546-15547	-LRB-	denotes	(
T34626	15547-15548	NN	denotes	F
T34627	15557-15567	NNS	denotes	amplitudes
T34628	15548-15549	-RRB-	denotes	)
T34629	15550-15551	NN	denotes	b
T34630	15552-15556	NN	denotes	wave
T34631	15551-15552	HYPH	denotes	-
T34632	15568-15570	IN	denotes	as
T34633	15571-15572	DT	denotes	a
T34634	15573-15581	NN	denotes	function
T34635	15582-15584	IN	denotes	of
T34636	15585-15588	DT	denotes	the
T34637	15589-15598	NN	denotes	logarithm
T34638	15599-15601	IN	denotes	of
T34639	15602-15605	DT	denotes	the
T34640	15612-15621	NN	denotes	intensity
T34641	15606-15611	NN	denotes	flash
T34642	15622-15626	VBD	denotes	were
T34643	15637-15638	.	denotes	.
T34644	15638-15938	sentence	denotes	(F) Further illustrates that the relative influence of the mutations on the photoreceptors (indicated by the saturated a-wave amplitude, right graph) was not substantially different from their effect on the b-wave response (dominated by the bipolars, left graph) at the same intensity of 10 cd·s/m2.
T34645	15639-15640	-LRB-	denotes	(
T34646	15651-15662	VBZ	denotes	illustrates
T34647	15640-15641	NN	denotes	F
T34648	15641-15642	-RRB-	denotes	)
T34649	15643-15650	RB	denotes	Further
T34650	15663-15667	IN	denotes	that
T34651	15789-15792	VBD	denotes	was
T34652	15668-15671	DT	denotes	the
T34653	15681-15690	NN	denotes	influence
T34654	15672-15680	JJ	denotes	relative
T34655	15691-15693	IN	denotes	of
T34656	15694-15697	DT	denotes	the
T34657	15698-15707	NNS	denotes	mutations
T34658	15708-15710	IN	denotes	on
T34659	15711-15714	DT	denotes	the
T34660	15715-15729	NNS	denotes	photoreceptors
T34661	15730-15731	-LRB-	denotes	(
T34662	15731-15740	VBN	denotes	indicated
T34663	15741-15743	IN	denotes	by
T34664	15744-15747	DT	denotes	the
T34665	15765-15774	NN	denotes	amplitude
T34666	15748-15757	VBN	denotes	saturated
T34667	15758-15759	NN	denotes	a
T34668	15760-15764	NN	denotes	wave
T34669	15759-15760	HYPH	denotes	-
T34670	15774-15776	,	denotes	,
T34671	15782-15787	NN	denotes	graph
T34672	15776-15781	JJ	denotes	right
T34673	15787-15788	-RRB-	denotes	)
T34674	15793-15796	RB	denotes	not
T34675	15797-15810	RB	denotes	substantially
T34676	15811-15820	JJ	denotes	different
T34677	15821-15825	IN	denotes	from
T34678	15826-15831	PRP$	denotes	their
T34679	15832-15838	NN	denotes	effect
T34680	15839-15841	IN	denotes	on
T34681	15842-15845	DT	denotes	the
T34682	15853-15861	NN	denotes	response
T34683	15846-15847	NN	denotes	b
T34684	15848-15852	NN	denotes	wave
T34685	15847-15848	HYPH	denotes	-
T34686	15862-15863	-LRB-	denotes	(
T34687	15863-15872	VBN	denotes	dominated
T34688	15873-15875	IN	denotes	by
T34689	15876-15879	DT	denotes	the
T34690	15880-15888	NNS	denotes	bipolars
T34691	15888-15890	,	denotes	,
T34692	15895-15900	NN	denotes	graph
T34693	15890-15894	JJ	denotes	left
T34694	15900-15901	-RRB-	denotes	)
T34695	15902-15904	IN	denotes	at
T34696	15905-15908	DT	denotes	the
T34697	15914-15923	NN	denotes	intensity
T34698	15909-15913	JJ	denotes	same
T34699	15924-15926	IN	denotes	of
T34700	15927-15929	CD	denotes	10
T34701	15933-15934	NN	denotes	s
T34702	15930-15932	NN	denotes	cd
T34703	15932-15933	SYM	denotes	·
T34704	15934-15935	SYM	denotes	/
T34705	15935-15937	NN	denotes	m2
T34706	15937-15938	.	denotes	.
T35139	23760-23762	IN	denotes	of
T35140	23763-23765	NN	denotes	WT
T35141	23790-23796	NN	denotes	retina
T35125	23694-23709	NN	denotes	Differentiation
T35126	23710-23717	NNS	denotes	Defects
T35127	23718-23720	IN	denotes	in
T35128	23721-23723	NN	denotes	Rb
T35129	23724-23726	NN	denotes	KO
T35130	23727-23731	NNS	denotes	SACs
T35131	23731-23868	sentence	denotes	(A) P18 horizontal sections of WT, Rb KO, and Rb/E2f1 DKO retina were stained for nuclei (DAPI, blue), Calb2 (green), and Slc18a3 (red).
T35132	23732-23733	-LRB-	denotes	(
T35133	23733-23734	LS	denotes	A
T35134	23802-23809	VBN	denotes	stained
T35135	23734-23735	-RRB-	denotes	)
T35136	23736-23739	NN	denotes	P18
T35137	23751-23759	NNS	denotes	sections
T35138	23740-23750	JJ	denotes	horizontal
T35142	23765-23767	,	denotes	,
T35143	23767-23769	NN	denotes	Rb
T35144	23770-23772	NN	denotes	KO
T35145	23772-23774	,	denotes	,
T35146	23774-23777	CC	denotes	and
T35147	23778-23780	NN	denotes	Rb
T35148	23781-23785	NN	denotes	E2f1
T35149	23780-23781	HYPH	denotes	/
T35150	23786-23789	NN	denotes	DKO
T35151	23797-23801	VBD	denotes	were
T35152	23810-23813	IN	denotes	for
T35153	23814-23820	NNS	denotes	nuclei
T35154	23821-23822	-LRB-	denotes	(
T35155	23828-23832	JJ	denotes	blue
T35156	23822-23826	NN	denotes	DAPI
T35157	23826-23828	,	denotes	,
T35158	23832-23833	-RRB-	denotes	)
T35159	23833-23835	,	denotes	,
T35160	23835-23840	NN	denotes	Calb2
T35161	23841-23842	-LRB-	denotes	(
T35162	23842-23847	JJ	denotes	green
T35163	23847-23848	-RRB-	denotes	)
T35164	23848-23850	,	denotes	,
T35165	23850-23853	CC	denotes	and
T35166	23854-23861	NN	denotes	Slc18a3
T35167	23862-23863	-LRB-	denotes	(
T35168	23863-23866	JJ	denotes	red
T35169	23866-23867	-RRB-	denotes	)
T35170	23867-23868	.	denotes	.
T35171	23868-24025	sentence	denotes	(B) Confocal images of P30 horizontal sections of WT and Rb KO retina were stained for nuclei (DAPI, blue), Chat and Slc18a3 (both red), and Camk2a (green).
T35172	23869-23870	-LRB-	denotes	(
T35173	23870-23871	LS	denotes	B
T35174	23944-23951	VBN	denotes	stained
T35175	23871-23872	-RRB-	denotes	)
T35176	23873-23881	JJ	denotes	Confocal
T35177	23882-23888	NNS	denotes	images
T35178	23889-23891	IN	denotes	of
T35179	23892-23895	NN	denotes	P30
T35180	23907-23915	NNS	denotes	sections
T35181	23896-23906	JJ	denotes	horizontal
T35182	23916-23918	IN	denotes	of
T35183	23919-23921	NN	denotes	WT
T35184	23932-23938	NN	denotes	retina
T35185	23922-23925	CC	denotes	and
T35186	23926-23928	NN	denotes	Rb
T35187	23929-23931	NN	denotes	KO
T35188	23939-23943	VBD	denotes	were
T35189	23952-23955	IN	denotes	for
T35190	23956-23962	NNS	denotes	nuclei
T35191	23963-23964	-LRB-	denotes	(
T35192	23964-23968	NN	denotes	DAPI
T35193	23968-23970	,	denotes	,
T35194	23970-23974	JJ	denotes	blue
T35195	23974-23975	-RRB-	denotes	)
T35196	23975-23977	,	denotes	,
T35197	23977-23981	NN	denotes	Chat
T35198	23982-23985	CC	denotes	and
T35199	23986-23993	NN	denotes	Slc18a3
T35200	23994-23995	-LRB-	denotes	(
T35201	24000-24003	JJ	denotes	red
T35202	23995-23999	RB	denotes	both
T35203	24003-24004	-RRB-	denotes	)
T35204	24004-24006	,	denotes	,
T35205	24006-24009	CC	denotes	and
T35206	24010-24016	NN	denotes	Camk2a
T35207	24017-24018	-LRB-	denotes	(
T35208	24018-24023	JJ	denotes	green
T35209	24023-24024	-RRB-	denotes	)
T35210	24024-24025	.	denotes	.
T35211	24025-24108	sentence	denotes	In the Rb KO section, the red stain is Chat only, as Slc18a3 is missing (see [A]).
T35212	24026-24028	IN	denotes	In
T35213	24062-24064	VBZ	denotes	is
T35214	24029-24032	DT	denotes	the
T35215	24039-24046	NN	denotes	section
T35216	24033-24035	NN	denotes	Rb
T35217	24036-24038	NN	denotes	KO
T35218	24046-24048	,	denotes	,
T35219	24048-24051	DT	denotes	the
T35220	24056-24061	NN	denotes	stain
T35221	24052-24055	JJ	denotes	red
T35222	24065-24069	NN	denotes	Chat
T35223	24070-24074	RB	denotes	only
T35224	24074-24076	,	denotes	,
T35225	24076-24078	IN	denotes	as
T35226	24090-24097	VBG	denotes	missing
T35227	24079-24086	NN	denotes	Slc18a3
T35228	24087-24089	VBZ	denotes	is
T35229	24098-24099	-LRB-	denotes	(
T35230	24099-24102	VB	denotes	see
T35231	24103-24104	-LRB-	denotes	[
T35232	24104-24105	NN	denotes	A
T35233	24105-24106	-RRB-	denotes	]
T35234	24106-24107	-RRB-	denotes	)
T35235	24107-24108	.	denotes	.
T35236	24108-24231	sentence	denotes	(C) Quantification of dense Calb2+ cell bodies in the INL, total Slc18a3+ cell bodies, and Camk2a+ cell bodies in the INL.
T35237	24109-24110	-LRB-	denotes	(
T35238	24110-24111	LS	denotes	C
T35239	24113-24127	NN	denotes	Quantification
T35240	24111-24112	-RRB-	denotes	)
T35241	24128-24130	IN	denotes	of
T35242	24131-24136	JJ	denotes	dense
T35243	24149-24155	NNS	denotes	bodies
T35244	24137-24142	NN	denotes	Calb2
T35245	24142-24143	SYM	denotes	+
T35246	24144-24148	NN	denotes	cell
T35247	24156-24158	IN	denotes	in
T35248	24159-24162	DT	denotes	the
T35249	24163-24166	NN	denotes	INL
T35250	24166-24168	,	denotes	,
T35251	24168-24173	JJ	denotes	total
T35252	24188-24194	NNS	denotes	bodies
T35253	24174-24181	NN	denotes	Slc18a3
T35254	24181-24182	SYM	denotes	+
T35255	24183-24187	NN	denotes	cell
T35256	24194-24196	,	denotes	,
T35257	24196-24199	CC	denotes	and
T35258	24200-24206	NN	denotes	Camk2a
T35259	24213-24219	NNS	denotes	bodies
T35260	24206-24207	SYM	denotes	+
T35261	24208-24212	NN	denotes	cell
T35262	24220-24222	IN	denotes	in
T35263	24223-24226	DT	denotes	the
T35264	24227-24230	NN	denotes	INL
T35265	24230-24231	.	denotes	.
T35266	24231-24441	sentence	denotes	Error bars represent SD of measurements from three animals, and asterisks indicate significant differences between retinas of WT and the indicated genotypes (, p <0.05; *; p <0.01; ANOVA and Tukey HSD test).
T35267	24232-24237	NN	denotes	Error
T35268	24238-24242	NNS	denotes	bars
T35269	24243-24252	VBP	denotes	represent
T35270	24253-24255	NN	denotes	SD
T35271	24256-24258	IN	denotes	of
T35272	24259-24271	NNS	denotes	measurements
T35273	24272-24276	IN	denotes	from
T35274	24277-24282	CD	denotes	three
T35275	24283-24290	NNS	denotes	animals
T35276	24290-24292	,	denotes	,
T35277	24292-24295	CC	denotes	and
T35278	24296-24305	NNS	denotes	asterisks
T35279	24306-24314	VBP	denotes	indicate
T35280	24315-24326	JJ	denotes	significant
T35281	24327-24338	NNS	denotes	differences
T35282	24339-24346	IN	denotes	between
T35283	24347-24354	NNS	denotes	retinas
T35284	24355-24357	IN	denotes	of
T35285	24358-24360	NN	denotes	WT
T35286	24361-24364	CC	denotes	and
T35287	24365-24368	DT	denotes	the
T35288	24379-24388	NNS	denotes	genotypes
T35289	24369-24378	VBN	denotes	indicated
T35290	24389-24390	-LRB-	denotes	(
T35291	24435-24439	NN	denotes	test
T35292	24390-24391	SYM	denotes	*
T35293	24396-24400	CD	denotes	0.05
T35294	24391-24393	,	denotes	,
T35295	24393-24394	NN	denotes	p
T35296	24395-24396	SYM	denotes	<
T35297	24400-24401	:	denotes	;
T35298	24402-24404	SYM	denotes	**
T35299	24409-24413	CD	denotes	0.01
T35300	24404-24405	:	denotes	;
T35301	24406-24407	NN	denotes	p
T35302	24408-24409	SYM	denotes	<
T35303	24413-24414	:	denotes	;
T35304	24415-24420	NN	denotes	ANOVA
T35305	24421-24424	CC	denotes	and
T35306	24425-24430	NNP	denotes	Tukey
T35307	24431-24434	NN	denotes	HSD
T35308	24439-24440	-RRB-	denotes	)
T35309	24440-24441	.	denotes	.
T35310	24441-24487	sentence	denotes	Scale bars are 50 μm in (A) and 20 μm in (B).
T35311	24442-24447	NN	denotes	Scale
T35312	24448-24452	NNS	denotes	bars
T35313	24453-24456	VBP	denotes	are
T35314	24457-24459	CD	denotes	50
T35315	24460-24462	NN	denotes	μm
T35316	24463-24465	IN	denotes	in
T35317	24466-24467	-LRB-	denotes	(
T35318	24467-24468	NN	denotes	A
T35319	24468-24469	-RRB-	denotes	)
T35320	24470-24473	CC	denotes	and
T35321	24474-24476	CD	denotes	20
T35322	24477-24479	NN	denotes	μm
T35323	24480-24482	IN	denotes	in
T35324	24483-24484	-LRB-	denotes	(
T35325	24484-24485	NN	denotes	B
T35326	24485-24486	-RRB-	denotes	)
T35327	24486-24487	.	denotes	.
T36048	28074-28078	NN	denotes	E2f3
T36049	28079-28083	NN	denotes	Loss
T36050	28084-28091	VBZ	denotes	Rescues
T36051	28092-28107	NN	denotes	Differentiation
T36052	28108-28110	IN	denotes	of
T36053	28111-28113	NN	denotes	Rb
T36054	28114-28116	NN	denotes	KO
T36055	28117-28121	NNS	denotes	SACs
T36056	28121-28343	sentence	denotes	(A) Horizontal retinal sections of the indicated ages and genotypes were stained for nuclei (DAPI, blue), mitosis marker PH3 (green), and Slc18a3 (red), which marks SAC soma at early stages and processes from ~P5 onwards.
T36057	28122-28123	-LRB-	denotes	(
T36058	28123-28124	LS	denotes	A
T36059	28195-28202	VBN	denotes	stained
T36060	28124-28125	-RRB-	denotes	)
T36061	28126-28136	JJ	denotes	Horizontal
T36062	28145-28153	NNS	denotes	sections
T36063	28137-28144	JJ	denotes	retinal
T36064	28154-28156	IN	denotes	of
T36065	28157-28160	DT	denotes	the
T36066	28171-28175	NNS	denotes	ages
T36067	28161-28170	VBN	denotes	indicated
T36068	28176-28179	CC	denotes	and
T36069	28180-28189	NNS	denotes	genotypes
T36070	28190-28194	VBD	denotes	were
T36071	28203-28206	IN	denotes	for
T36072	28207-28213	NNS	denotes	nuclei
T36073	28214-28215	-LRB-	denotes	(
T36074	28221-28225	JJ	denotes	blue
T36075	28215-28219	NN	denotes	DAPI
T36076	28219-28221	,	denotes	,
T36077	28225-28226	-RRB-	denotes	)
T36078	28226-28228	,	denotes	,
T36079	28228-28235	NN	denotes	mitosis
T36080	28236-28242	NN	denotes	marker
T36081	28243-28246	NN	denotes	PH3
T36082	28247-28248	-LRB-	denotes	(
T36083	28248-28253	JJ	denotes	green
T36084	28253-28254	-RRB-	denotes	)
T36085	28254-28256	,	denotes	,
T36086	28256-28259	CC	denotes	and
T36087	28260-28267	NN	denotes	Slc18a3
T36088	28268-28269	-LRB-	denotes	(
T36089	28269-28272	JJ	denotes	red
T36090	28272-28273	-RRB-	denotes	)
T36091	28273-28275	,	denotes	,
T36092	28275-28280	WDT	denotes	which
T36093	28281-28286	VBZ	denotes	marks
T36094	28287-28290	NN	denotes	SAC
T36095	28291-28295	NN	denotes	soma
T36096	28296-28298	IN	denotes	at
T36097	28299-28304	JJ	denotes	early
T36098	28305-28311	NNS	denotes	stages
T36099	28312-28315	CC	denotes	and
T36100	28316-28325	NNS	denotes	processes
T36101	28326-28330	IN	denotes	from
T36102	28331-28332	SYM	denotes	~
T36103	28332-28334	NN	denotes	P5
T36104	28335-28342	RB	denotes	onwards
T36105	28342-28343	.	denotes	.
T36106	28343-28423	sentence	denotes	Arrows show mitotic PH3+ nuclei in Rb KO, Rb/E2f2 DKO, and Rb/E2f3 DKO retinas.
T36107	28344-28350	NNS	denotes	Arrows
T36108	28351-28355	VBP	denotes	show
T36109	28356-28363	JJ	denotes	mitotic
T36110	28369-28375	NNS	denotes	nuclei
T36111	28364-28367	NN	denotes	PH3
T36112	28367-28368	SYM	denotes	+
T36113	28376-28378	IN	denotes	in
T36114	28379-28381	NN	denotes	Rb
T36115	28382-28384	NN	denotes	KO
T36116	28415-28422	NNS	denotes	retinas
T36117	28384-28386	,	denotes	,
T36118	28386-28388	NN	denotes	Rb
T36119	28389-28393	NN	denotes	E2f2
T36120	28388-28389	HYPH	denotes	/
T36121	28394-28397	NN	denotes	DKO
T36122	28397-28399	,	denotes	,
T36123	28399-28402	CC	denotes	and
T36124	28403-28405	NN	denotes	Rb
T36125	28406-28410	NN	denotes	E2f3
T36126	28405-28406	HYPH	denotes	/
T36127	28411-28414	NN	denotes	DKO
T36128	28422-28423	.	denotes	.
T36129	28423-28509	sentence	denotes	E2f1 loss rescues the ectopic mitosis and cell death defects, but not the SAC defect.
T36130	28424-28428	NN	denotes	E2f1
T36131	28429-28433	NN	denotes	loss
T36132	28434-28441	VBZ	denotes	rescues
T36133	28442-28445	DT	denotes	the
T36134	28477-28484	NNS	denotes	defects
T36135	28446-28453	JJ	denotes	ectopic
T36136	28454-28461	NN	denotes	mitosis
T36137	28462-28465	CC	denotes	and
T36138	28466-28470	NN	denotes	cell
T36139	28471-28476	NN	denotes	death
T36140	28484-28486	,	denotes	,
T36141	28486-28489	CC	denotes	but
T36142	28490-28493	RB	denotes	not
T36143	28494-28497	DT	denotes	the
T36144	28502-28508	NN	denotes	defect
T36145	28498-28501	NN	denotes	SAC
T36146	28508-28509	.	denotes	.
T36147	28509-28534	sentence	denotes	E2f2 loss has no effect.
T36148	28510-28514	NN	denotes	E2f2
T36149	28515-28519	NN	denotes	loss
T36150	28520-28523	VBZ	denotes	has
T36151	28524-28526	DT	denotes	no
T36152	28527-28533	NN	denotes	effect
T36153	28533-28534	.	denotes	.
T36154	28534-28631	sentence	denotes	E2f3 loss does not rescue the ectopic mitosis and cell loss defects, but rescues the SAC defect.
T36155	28535-28539	NN	denotes	E2f3
T36156	28540-28544	NN	denotes	loss
T36157	28554-28560	VB	denotes	rescue
T36158	28545-28549	VBZ	denotes	does
T36159	28550-28553	RB	denotes	not
T36160	28561-28564	DT	denotes	the
T36161	28595-28602	NNS	denotes	defects
T36162	28565-28572	JJ	denotes	ectopic
T36163	28573-28580	NN	denotes	mitosis
T36164	28581-28584	CC	denotes	and
T36165	28585-28589	NN	denotes	cell
T36166	28590-28594	NN	denotes	loss
T36167	28602-28604	,	denotes	,
T36168	28604-28607	CC	denotes	but
T36169	28608-28615	VBZ	denotes	rescues
T36170	28616-28619	DT	denotes	the
T36171	28624-28630	NN	denotes	defect
T36172	28620-28623	NN	denotes	SAC
T36173	28630-28631	.	denotes	.
T36174	28631-28725	sentence	denotes	Inactivating E2f1 and E2f3 together rescues the ectopic mitosis, cell death, and SAC defects.
T36175	28632-28644	VBG	denotes	Inactivating
T36176	28668-28675	VBZ	denotes	rescues
T36177	28645-28649	NN	denotes	E2f1
T36178	28650-28653	CC	denotes	and
T36179	28654-28658	NN	denotes	E2f3
T36180	28659-28667	RB	denotes	together
T36181	28676-28679	DT	denotes	the
T36182	28717-28724	NNS	denotes	defects
T36183	28680-28687	JJ	denotes	ectopic
T36184	28688-28695	NN	denotes	mitosis
T36185	28695-28697	,	denotes	,
T36186	28697-28701	NN	denotes	cell
T36187	28702-28707	NN	denotes	death
T36188	28707-28709	,	denotes	,
T36189	28709-28712	CC	denotes	and
T36190	28713-28716	NN	denotes	SAC
T36191	28724-28725	.	denotes	.
T36192	28725-28807	sentence	denotes	(B) The fraction of Camk2a+ cells that are Chat + and Slc18a3+ in the P30 retina.
T36193	28726-28727	-LRB-	denotes	(
T36194	28727-28728	LS	denotes	B
T36195	28734-28742	NN	denotes	fraction
T36196	28728-28729	-RRB-	denotes	)
T36197	28730-28733	DT	denotes	The
T36198	28743-28745	IN	denotes	of
T36199	28746-28752	NN	denotes	Camk2a
T36200	28754-28759	NNS	denotes	cells
T36201	28752-28753	SYM	denotes	+
T36202	28760-28764	WDT	denotes	that
T36203	28765-28768	VBP	denotes	are
T36204	28769-28773	NN	denotes	Chat
T36205	28774-28775	SYM	denotes	+
T36206	28776-28779	CC	denotes	and
T36207	28780-28787	NN	denotes	Slc18a3
T36208	28787-28788	SYM	denotes	+
T36209	28789-28791	IN	denotes	in
T36210	28792-28795	DT	denotes	the
T36211	28800-28806	NN	denotes	retina
T36212	28796-28799	NN	denotes	P30
T36213	28806-28807	.	denotes	.
T36214	28807-28913	sentence	denotes	(C) Horizontal P5 retinal sections were stained for nuclei (DAPI, blue), Slc18a3 (green), and Isl1 (red).
T36215	28808-28809	-LRB-	denotes	(
T36216	28809-28810	LS	denotes	C
T36217	28848-28855	VBN	denotes	stained
T36218	28810-28811	-RRB-	denotes	)
T36219	28812-28822	JJ	denotes	Horizontal
T36220	28834-28842	NNS	denotes	sections
T36221	28823-28825	NN	denotes	P5
T36222	28826-28833	NN	denotes	retinal
T36223	28843-28847	VBD	denotes	were
T36224	28856-28859	IN	denotes	for
T36225	28860-28866	NNS	denotes	nuclei
T36226	28867-28868	-LRB-	denotes	(
T36227	28874-28878	JJ	denotes	blue
T36228	28868-28872	NN	denotes	DAPI
T36229	28872-28874	,	denotes	,
T36230	28878-28879	-RRB-	denotes	)
T36231	28879-28881	,	denotes	,
T36232	28881-28888	NN	denotes	Slc18a3
T36233	28889-28890	-LRB-	denotes	(
T36234	28890-28895	JJ	denotes	green
T36235	28895-28896	-RRB-	denotes	)
T36236	28896-28898	,	denotes	,
T36237	28898-28901	CC	denotes	and
T36238	28902-28906	NN	denotes	Isl1
T36239	28907-28908	-LRB-	denotes	(
T36240	28908-28911	JJ	denotes	red
T36241	28911-28912	-RRB-	denotes	)
T36242	28912-28913	.	denotes	.
T36243	28913-28980	sentence	denotes	Arrows show double-labelled Isl1+/Slc18a3+ cells in the inner INL.
T36244	28914-28920	NNS	denotes	Arrows
T36245	28921-28925	VBP	denotes	show
T36246	28926-28932	JJ	denotes	double
T36247	28933-28941	VBN	denotes	labelled
T36248	28932-28933	HYPH	denotes	-
T36249	28957-28962	NNS	denotes	cells
T36250	28942-28946	NN	denotes	Isl1
T36251	28946-28947	SYM	denotes	+
T36252	28947-28948	HYPH	denotes	/
T36253	28948-28955	NN	denotes	Slc18a3
T36254	28955-28956	SYM	denotes	+
T36255	28963-28965	IN	denotes	in
T36256	28966-28969	DT	denotes	the
T36257	28976-28979	NN	denotes	INL
T36258	28970-28975	JJ	denotes	inner
T36259	28979-28980	.	denotes	.
T36260	28980-29132	sentence	denotes	(D) Horizontal P0 retinal sections of the indicated genotypes were stained for nuclei (DAPI, blue), cell division marker Mki67 (green), and Isl1 (red).
T36261	28981-28982	-LRB-	denotes	(
T36262	28982-28983	LS	denotes	D
T36263	29048-29055	VBN	denotes	stained
T36264	28983-28984	-RRB-	denotes	)
T36265	28985-28995	JJ	denotes	Horizontal
T36266	29007-29015	NNS	denotes	sections
T36267	28996-28998	NN	denotes	P0
T36268	28999-29006	JJ	denotes	retinal
T36269	29016-29018	IN	denotes	of
T36270	29019-29022	DT	denotes	the
T36271	29033-29042	NNS	denotes	genotypes
T36272	29023-29032	VBN	denotes	indicated
T36273	29043-29047	VBD	denotes	were
T36274	29056-29059	IN	denotes	for
T36275	29060-29066	NNS	denotes	nuclei
T36276	29067-29068	-LRB-	denotes	(
T36277	29074-29078	JJ	denotes	blue
T36278	29068-29072	NN	denotes	DAPI
T36279	29072-29074	,	denotes	,
T36280	29078-29079	-RRB-	denotes	)
T36281	29079-29081	,	denotes	,
T36282	29081-29085	NN	denotes	cell
T36283	29086-29094	NN	denotes	division
T36284	29095-29101	NN	denotes	marker
T36285	29102-29107	NN	denotes	Mki67
T36286	29108-29109	-LRB-	denotes	(
T36287	29109-29114	JJ	denotes	green
T36288	29114-29115	-RRB-	denotes	)
T36289	29115-29117	,	denotes	,
T36290	29117-29120	CC	denotes	and
T36291	29121-29125	NN	denotes	Isl1
T36292	29126-29127	-LRB-	denotes	(
T36293	29127-29130	JJ	denotes	red
T36294	29130-29131	-RRB-	denotes	)
T36295	29131-29132	.	denotes	.
T36296	29132-29175	sentence	denotes	Arrows show double-labelled dividing SACs.
T36297	29133-29139	NNS	denotes	Arrows
T36298	29140-29144	VBP	denotes	show
T36299	29145-29151	JJ	denotes	double
T36300	29152-29160	VBN	denotes	labelled
T36301	29151-29152	HYPH	denotes	-
T36302	29170-29174	NNS	denotes	SACs
T36303	29161-29169	VBG	denotes	dividing
T36304	29174-29175	.	denotes	.
T36305	29175-29273	sentence	denotes	(E) The fraction of Isl1+ cells in the inner NBL (INBL) of P0 retinas that are dividing (Mki67+).
T36306	29176-29177	-LRB-	denotes	(
T36307	29177-29178	LS	denotes	E
T36308	29184-29192	NN	denotes	fraction
T36309	29178-29179	-RRB-	denotes	)
T36310	29180-29183	DT	denotes	The
T36311	29193-29195	IN	denotes	of
T36312	29196-29200	NN	denotes	Isl1
T36313	29202-29207	NNS	denotes	cells
T36314	29200-29201	SYM	denotes	+
T36315	29208-29210	IN	denotes	in
T36316	29211-29214	DT	denotes	the
T36317	29221-29224	NN	denotes	NBL
T36318	29215-29220	JJ	denotes	inner
T36319	29225-29226	-LRB-	denotes	(
T36320	29226-29230	NN	denotes	INBL
T36321	29230-29231	-RRB-	denotes	)
T36322	29232-29234	IN	denotes	of
T36323	29235-29237	NN	denotes	P0
T36324	29238-29245	NNS	denotes	retinas
T36325	29246-29250	WDT	denotes	that
T36326	29255-29263	VBG	denotes	dividing
T36327	29251-29254	VBP	denotes	are
T36328	29264-29265	-LRB-	denotes	(
T36329	29265-29270	NN	denotes	Mki67
T36330	29270-29271	SYM	denotes	+
T36331	29271-29272	-RRB-	denotes	)
T36332	29272-29273	.	denotes	.
T36333	29273-29483	sentence	denotes	Error bars represent SD of measurements from three animals, and asterisks indicate significant differences between retinas of WT and the indicated genotypes (, p <0.05; *; p <0.01; ANOVA and Tukey HSD test).
T36334	29274-29279	NN	denotes	Error
T36335	29280-29284	NNS	denotes	bars
T36336	29285-29294	VBP	denotes	represent
T36337	29295-29297	NN	denotes	SD
T36338	29298-29300	IN	denotes	of
T36339	29301-29313	NNS	denotes	measurements
T36340	29314-29318	IN	denotes	from
T36341	29319-29324	CD	denotes	three
T36342	29325-29332	NNS	denotes	animals
T36343	29332-29334	,	denotes	,
T36344	29334-29337	CC	denotes	and
T36345	29338-29347	NNS	denotes	asterisks
T36346	29348-29356	VBP	denotes	indicate
T36347	29357-29368	JJ	denotes	significant
T36348	29369-29380	NNS	denotes	differences
T36349	29381-29388	IN	denotes	between
T36350	29389-29396	NNS	denotes	retinas
T36351	29397-29399	IN	denotes	of
T36352	29400-29402	NN	denotes	WT
T36353	29403-29406	CC	denotes	and
T36354	29407-29410	DT	denotes	the
T36355	29411-29420	VBN	denotes	indicated
T36356	29421-29430	NNS	denotes	genotypes
T36357	29431-29432	-LRB-	denotes	(
T36358	29477-29481	NN	denotes	test
T36359	29432-29433	SYM	denotes	*
T36360	29438-29442	CD	denotes	0.05
T36361	29433-29435	,	denotes	,
T36362	29435-29436	NN	denotes	p
T36363	29437-29438	SYM	denotes	<
T36364	29442-29443	:	denotes	;
T36365	29444-29446	SYM	denotes	**
T36366	29451-29455	CD	denotes	0.01
T36367	29446-29447	:	denotes	;
T36368	29448-29449	NN	denotes	p
T36369	29450-29451	SYM	denotes	<
T36370	29455-29456	:	denotes	;
T36371	29457-29462	NN	denotes	ANOVA
T36372	29463-29466	CC	denotes	and
T36373	29467-29472	NNP	denotes	Tukey
T36374	29473-29476	NN	denotes	HSD
T36375	29481-29482	-RRB-	denotes	)
T36376	29482-29483	.	denotes	.
T36377	29483-29526	sentence	denotes	Scale bars in (A), (C), and (D) are 50 μm.
T36378	29484-29489	NN	denotes	Scale
T36379	29490-29494	NNS	denotes	bars
T36380	29516-29519	VBP	denotes	are
T36381	29495-29497	IN	denotes	in
T36382	29498-29499	-LRB-	denotes	(
T36383	29499-29500	NN	denotes	A
T36384	29500-29501	-RRB-	denotes	)
T36385	29501-29503	,	denotes	,
T36386	29503-29504	-LRB-	denotes	(
T36387	29504-29505	NN	denotes	C
T36388	29505-29506	-RRB-	denotes	)
T36389	29506-29508	,	denotes	,
T36390	29508-29511	CC	denotes	and
T36391	29512-29513	-LRB-	denotes	(
T36392	29513-29514	NN	denotes	D
T36393	29514-29515	-RRB-	denotes	)
T36394	29520-29522	CD	denotes	50
T36395	29523-29525	NN	denotes	μm
T36396	29525-29526	.	denotes	.
T36780	34979-34983	NN	denotes	E2f3
T36781	34991-35001	NN	denotes	Expression
T36782	34984-34987	CC	denotes	and
T36783	34988-34990	NN	denotes	Rb
T36784	35002-35004	IN	denotes	in
T36785	35005-35009	NNS	denotes	SACs
T36786	35009-35142	sentence	denotes	(A) Left panels: horizontal P0, P8, and P18 retinal sections of the indicated genotypes were stained for E2f3 (red) and DAPI (blue).
T36787	35010-35011	-LRB-	denotes	(
T36788	35011-35012	LS	denotes	A
T36789	35103-35110	VBN	denotes	stained
T36790	35012-35013	-RRB-	denotes	)
T36791	35014-35018	JJ	denotes	Left
T36792	35019-35025	NNS	denotes	panels
T36793	35025-35027	:	denotes	:
T36794	35027-35037	JJ	denotes	horizontal
T36795	35062-35070	NNS	denotes	sections
T36796	35038-35040	NN	denotes	P0
T36797	35040-35042	,	denotes	,
T36798	35042-35044	NN	denotes	P8
T36799	35044-35046	,	denotes	,
T36800	35046-35049	CC	denotes	and
T36801	35050-35053	NN	denotes	P18
T36802	35054-35061	JJ	denotes	retinal
T36803	35071-35073	IN	denotes	of
T36804	35074-35077	DT	denotes	the
T36805	35088-35097	NNS	denotes	genotypes
T36806	35078-35087	VBN	denotes	indicated
T36807	35098-35102	VBD	denotes	were
T36808	35111-35114	IN	denotes	for
T36809	35115-35119	NN	denotes	E2f3
T36810	35120-35121	-LRB-	denotes	(
T36811	35121-35124	JJ	denotes	red
T36812	35124-35125	-RRB-	denotes	)
T36813	35126-35129	CC	denotes	and
T36814	35130-35134	NN	denotes	DAPI
T36815	35135-35136	-LRB-	denotes	(
T36816	35136-35140	JJ	denotes	blue
T36817	35140-35141	-RRB-	denotes	)
T36818	35141-35142	.	denotes	.
T36819	35142-35234	sentence	denotes	The arrow indicates the junction between the E2f3 null peripheral and WT central P0 retina.
T36820	35143-35146	DT	denotes	The
T36821	35147-35152	NN	denotes	arrow
T36822	35153-35162	VBZ	denotes	indicates
T36823	35163-35166	DT	denotes	the
T36824	35167-35175	NN	denotes	junction
T36825	35176-35183	IN	denotes	between
T36826	35184-35187	DT	denotes	the
T36827	35198-35208	JJ	denotes	peripheral
T36828	35188-35192	NN	denotes	E2f3
T36829	35193-35197	JJ	denotes	null
T36830	35209-35212	CC	denotes	and
T36831	35213-35215	NN	denotes	WT
T36832	35227-35233	NN	denotes	retina
T36833	35216-35223	JJ	denotes	central
T36834	35224-35226	NN	denotes	P0
T36835	35233-35234	.	denotes	.
T36836	35234-35352	sentence	denotes	Note the absence of E2f3 protein in the peripheral E2f3 KO RPCs at P0 and in peripheral inner retinal neurons at P18.
T36837	35235-35239	VB	denotes	Note
T36838	35240-35243	DT	denotes	the
T36839	35244-35251	NN	denotes	absence
T36840	35252-35254	IN	denotes	of
T36841	35255-35259	NN	denotes	E2f3
T36842	35260-35267	NN	denotes	protein
T36843	35268-35270	IN	denotes	in
T36844	35271-35274	DT	denotes	the
T36845	35294-35298	NNS	denotes	RPCs
T36846	35275-35285	JJ	denotes	peripheral
T36847	35286-35290	NN	denotes	E2f3
T36848	35291-35293	NN	denotes	KO
T36849	35299-35301	IN	denotes	at
T36850	35302-35304	NN	denotes	P0
T36851	35305-35308	CC	denotes	and
T36852	35309-35311	IN	denotes	in
T36853	35345-35347	IN	denotes	at
T36854	35312-35322	JJ	denotes	peripheral
T36855	35337-35344	NNS	denotes	neurons
T36856	35323-35328	JJ	denotes	inner
T36857	35329-35336	JJ	denotes	retinal
T36858	35348-35351	NN	denotes	P18
T36859	35351-35352	.	denotes	.
T36860	35352-35460	sentence	denotes	Far right panel: P18 retinal sections of the indicated genotypes were stained for Rb (red) and DAPI (blue).
T36861	35353-35356	RB	denotes	Far
T36862	35357-35362	JJ	denotes	right
T36863	35363-35368	NN	denotes	panel
T36864	35423-35430	VBN	denotes	stained
T36865	35368-35370	:	denotes	:
T36866	35370-35373	NN	denotes	P18
T36867	35382-35390	NNS	denotes	sections
T36868	35374-35381	JJ	denotes	retinal
T36869	35391-35393	IN	denotes	of
T36870	35394-35397	DT	denotes	the
T36871	35408-35417	NNS	denotes	genotypes
T36872	35398-35407	VBN	denotes	indicated
T36873	35418-35422	VBD	denotes	were
T36874	35431-35434	IN	denotes	for
T36875	35435-35437	NN	denotes	Rb
T36876	35438-35439	-LRB-	denotes	(
T36877	35439-35442	JJ	denotes	red
T36878	35442-35443	-RRB-	denotes	)
T36879	35444-35447	CC	denotes	and
T36880	35448-35452	NN	denotes	DAPI
T36881	35453-35454	-LRB-	denotes	(
T36882	35454-35458	JJ	denotes	blue
T36883	35458-35459	-RRB-	denotes	)
T36884	35459-35460	.	denotes	.
T36885	35460-35538	sentence	denotes	Note the absence of Rb protein in the peripheral Rb KO inner retinal neurons.
T36886	35461-35465	VB	denotes	Note
T36887	35466-35469	DT	denotes	the
T36888	35470-35477	NN	denotes	absence
T36889	35478-35480	IN	denotes	of
T36890	35481-35483	NN	denotes	Rb
T36891	35484-35491	NN	denotes	protein
T36892	35492-35494	IN	denotes	in
T36893	35495-35498	DT	denotes	the
T36894	35530-35537	NNS	denotes	neurons
T36895	35499-35509	JJ	denotes	peripheral
T36896	35510-35512	NN	denotes	Rb
T36897	35513-35515	NN	denotes	KO
T36898	35516-35521	JJ	denotes	inner
T36899	35522-35529	JJ	denotes	retinal
T36900	35537-35538	.	denotes	.
T36901	35538-35659	sentence	denotes	(B) WT P18 retinal sections were stained for nuclei (DAPI, blue), E2f3 (red) or Rb (red), and Chat plus Slc18a3 (green).
T36902	35539-35540	-LRB-	denotes	(
T36903	35540-35541	LS	denotes	B
T36904	35572-35579	VBN	denotes	stained
T36905	35541-35542	-RRB-	denotes	)
T36906	35543-35545	NN	denotes	WT
T36907	35558-35566	NNS	denotes	sections
T36908	35546-35549	NN	denotes	P18
T36909	35550-35557	JJ	denotes	retinal
T36910	35567-35571	VBD	denotes	were
T36911	35580-35583	IN	denotes	for
T36912	35584-35590	NNS	denotes	nuclei
T36913	35591-35592	-LRB-	denotes	(
T36914	35598-35602	JJ	denotes	blue
T36915	35592-35596	NN	denotes	DAPI
T36916	35596-35598	,	denotes	,
T36917	35602-35603	-RRB-	denotes	)
T36918	35603-35605	,	denotes	,
T36919	35605-35609	NN	denotes	E2f3
T36920	35610-35611	-LRB-	denotes	(
T36921	35611-35614	JJ	denotes	red
T36922	35614-35615	-RRB-	denotes	)
T36923	35616-35618	CC	denotes	or
T36924	35619-35621	NN	denotes	Rb
T36925	35622-35623	-LRB-	denotes	(
T36926	35623-35626	JJ	denotes	red
T36927	35626-35627	-RRB-	denotes	)
T36928	35627-35629	,	denotes	,
T36929	35629-35632	CC	denotes	and
T36930	35633-35637	NN	denotes	Chat
T36931	35638-35642	CC	denotes	plus
T36932	35643-35650	NN	denotes	Slc18a3
T36933	35651-35652	-LRB-	denotes	(
T36934	35652-35657	JJ	denotes	green
T36935	35657-35658	-RRB-	denotes	)
T36936	35658-35659	.	denotes	.
T36937	35659-35697	sentence	denotes	Arrows indicate double-labelled soma.
T36938	35660-35666	NNS	denotes	Arrows
T36939	35667-35675	VBP	denotes	indicate
T36940	35676-35682	JJ	denotes	double
T36941	35683-35691	VBN	denotes	labelled
T36942	35682-35683	HYPH	denotes	-
T36943	35692-35696	NNS	denotes	soma
T36944	35696-35697	.	denotes	.
T36945	35697-35751	sentence	denotes	Note that the IPL processes are also double-labelled.
T36946	35698-35702	VB	denotes	Note
T36947	35703-35707	IN	denotes	that
T36948	35742-35750	VBN	denotes	labelled
T36949	35708-35711	DT	denotes	the
T36950	35716-35725	NNS	denotes	processes
T36951	35712-35715	NN	denotes	IPL
T36952	35726-35729	VBP	denotes	are
T36953	35730-35734	RB	denotes	also
T36954	35735-35741	JJ	denotes	double
T36955	35741-35742	HYPH	denotes	-
T36956	35750-35751	.	denotes	.
T36957	35751-35773	sentence	denotes	Scale bars are 50 μm.
T36958	35752-35757	NN	denotes	Scale
T36959	35758-35762	NNS	denotes	bars
T36960	35763-35766	VBP	denotes	are
T36961	35767-35769	CD	denotes	50
T36962	35770-35772	NN	denotes	μm
T36963	35772-35773	.	denotes	.
T37145	38878-38889	JJ	denotes	Subcellular
T37146	38890-38902	NN	denotes	Distribution
T37147	38903-38905	IN	denotes	of
T37148	38906-38910	NN	denotes	E2f3
T37149	38911-38919	NNS	denotes	Isoforms
T37150	38920-38923	CC	denotes	and
T37151	38924-38929	JJ	denotes	Other
T37152	38941-38949	NNS	denotes	Proteins
T37153	38930-38934	NN	denotes	Cell
T37154	38935-38940	NN	denotes	Cycle
T37155	38950-38952	IN	denotes	in
T37156	38953-38956	DT	denotes	the
T37157	38968-38974	NN	denotes	Retina
T37158	38957-38967	VBG	denotes	Developing
T37159	38974-39164	sentence	denotes	Nuclear and cytoplasmic extracts from an equivalent number of retinal cells from mice of the indicated genotypes and ages were analyzed by Western blotting to detect the indicated proteins.
T37160	38975-38982	JJ	denotes	Nuclear
T37161	38999-39007	NNS	denotes	extracts
T37162	38983-38986	CC	denotes	and
T37163	38987-38998	JJ	denotes	cytoplasmic
T37164	39102-39110	VBN	denotes	analyzed
T37165	39008-39012	IN	denotes	from
T37166	39013-39015	DT	denotes	an
T37167	39027-39033	NN	denotes	number
T37168	39016-39026	JJ	denotes	equivalent
T37169	39034-39036	IN	denotes	of
T37170	39037-39044	JJ	denotes	retinal
T37171	39045-39050	NNS	denotes	cells
T37172	39051-39055	IN	denotes	from
T37173	39056-39060	NNS	denotes	mice
T37174	39061-39063	IN	denotes	of
T37175	39064-39067	DT	denotes	the
T37176	39078-39087	NNS	denotes	genotypes
T37177	39068-39077	VBN	denotes	indicated
T37178	39088-39091	CC	denotes	and
T37179	39092-39096	NNS	denotes	ages
T37180	39097-39101	VBD	denotes	were
T37181	39111-39113	IN	denotes	by
T37182	39114-39121	NNP	denotes	Western
T37183	39122-39130	NN	denotes	blotting
T37184	39131-39133	TO	denotes	to
T37185	39134-39140	VB	denotes	detect
T37186	39141-39144	DT	denotes	the
T37187	39155-39163	NN	denotes	proteins
T37188	39145-39154	VBN	denotes	indicated
T37189	39163-39164	.	denotes	.
T37190	39164-39254	sentence	denotes	Lysate from E2f3a−/− mice was used as a control to confirm the location of E2f3a protein.
T37191	39165-39171	NN	denotes	Lysate
T37192	39195-39199	VBN	denotes	used
T37193	39172-39176	IN	denotes	from
T37194	39177-39182	NN	denotes	E2f3a
T37195	39186-39190	NNS	denotes	mice
T37196	39182-39183	SYM	denotes	−
T37197	39183-39184	HYPH	denotes	/
T37198	39184-39185	SYM	denotes	−
T37199	39191-39194	VBD	denotes	was
T37200	39200-39202	IN	denotes	as
T37201	39203-39204	DT	denotes	a
T37202	39205-39212	NN	denotes	control
T37203	39213-39215	TO	denotes	to
T37204	39216-39223	VB	denotes	confirm
T37205	39224-39227	DT	denotes	the
T37206	39228-39236	NN	denotes	location
T37207	39237-39239	IN	denotes	of
T37208	39240-39245	NN	denotes	E2f3a
T37209	39246-39253	NN	denotes	protein
T37210	39253-39254	.	denotes	.
T37211	39254-39300	sentence	denotes	C, cytoplasmic extracts; N, nuclear extracts.
T37212	39255-39256	NN	denotes	C
T37213	39256-39258	,	denotes	,
T37214	39258-39269	JJ	denotes	cytoplasmic
T37215	39270-39278	NNS	denotes	extracts
T37216	39278-39279	:	denotes	;
T37217	39280-39281	NN	denotes	N
T37218	39281-39283	,	denotes	,
T37219	39283-39290	JJ	denotes	nuclear
T37220	39291-39299	NNS	denotes	extracts
T37221	39299-39300	.	denotes	.
T37919	39336-39339	DT	denotes	the
T37920	39356-39362	NN	denotes	Defect
T37921	39340-39355	NN	denotes	Differentiation
T37922	39363-39365	IN	denotes	in
T37923	39366-39368	NN	denotes	Rb
T37915	39311-39314	DT	denotes	The
T37916	39321-39328	NN	denotes	Isoform
T37917	39315-39320	NN	denotes	E2f3a
T37918	39329-39335	VBZ	denotes	Drives
T37924	39369-39371	NN	denotes	KO
T37925	39372-39376	NNS	denotes	SACs
T37926	39376-39510	sentence	denotes	(A) Schematic diagrams of the mouse WT, E2f3a−/−, and the Cre-recombined floxed E2f3 loci (indicated here as E2f3−/− for simplicity).
T37927	39377-39378	-LRB-	denotes	(
T37928	39378-39379	LS	denotes	A
T37929	39391-39399	NNS	denotes	diagrams
T37930	39379-39380	-RRB-	denotes	)
T37931	39381-39390	JJ	denotes	Schematic
T37932	39400-39402	IN	denotes	of
T37933	39403-39406	DT	denotes	the
T37934	39413-39415	NN	denotes	WT
T37935	39407-39412	NN	denotes	mouse
T37936	39415-39417	,	denotes	,
T37937	39417-39422	NN	denotes	E2f3a
T37938	39422-39423	SYM	denotes	−
T37939	39423-39424	HYPH	denotes	/
T37940	39424-39425	SYM	denotes	−
T37941	39425-39427	,	denotes	,
T37942	39427-39430	CC	denotes	and
T37943	39431-39434	DT	denotes	the
T37944	39462-39466	NNS	denotes	loci
T37945	39435-39438	NN	denotes	Cre
T37946	39438-39439	HYPH	denotes	-
T37947	39439-39449	VBN	denotes	recombined
T37948	39450-39456	VBN	denotes	floxed
T37949	39457-39461	NN	denotes	E2f3
T37950	39467-39468	-LRB-	denotes	(
T37951	39468-39477	VBN	denotes	indicated
T37952	39478-39482	RB	denotes	here
T37953	39483-39485	IN	denotes	as
T37954	39486-39490	NN	denotes	E2f3
T37955	39490-39491	SYM	denotes	−
T37956	39491-39492	HYPH	denotes	/
T37957	39492-39493	SYM	denotes	−
T37958	39494-39497	IN	denotes	for
T37959	39498-39508	NN	denotes	simplicity
T37960	39508-39509	-RRB-	denotes	)
T37961	39509-39510	.	denotes	.
T37962	39510-39590	sentence	denotes	E2f3a−/− mice lack most of E2f3 exon 1a and part of intron 1a (red dotted box).
T37963	39511-39516	NN	denotes	E2f3a
T37964	39520-39524	NNS	denotes	mice
T37965	39516-39517	SYM	denotes	−
T37966	39517-39518	HYPH	denotes	/
T37967	39518-39519	SYM	denotes	−
T37968	39525-39529	VBP	denotes	lack
T37969	39530-39534	JJS	denotes	most
T37970	39535-39537	IN	denotes	of
T37971	39538-39542	NN	denotes	E2f3
T37972	39548-39550	NN	denotes	1a
T37973	39543-39547	NN	denotes	exon
T37974	39551-39554	CC	denotes	and
T37975	39555-39559	NN	denotes	part
T37976	39560-39562	IN	denotes	of
T37977	39563-39569	NN	denotes	intron
T37978	39570-39572	NN	denotes	1a
T37979	39573-39574	-LRB-	denotes	(
T37980	39585-39588	NN	denotes	box
T37981	39574-39577	JJ	denotes	red
T37982	39578-39584	VBN	denotes	dotted
T37983	39588-39589	-RRB-	denotes	)
T37984	39589-39590	.	denotes	.
T37985	39590-39619	sentence	denotes	Arrows indicate PCR primers.
T37986	39591-39597	NNS	denotes	Arrows
T37987	39598-39606	VBP	denotes	indicate
T37988	39607-39610	NN	denotes	PCR
T37989	39611-39618	NNS	denotes	primers
T37990	39618-39619	.	denotes	.
T37991	39619-39674	sentence	denotes	Genotyping of an E2f3a+/− mouse is shown on the right.
T37992	39620-39630	NN	denotes	Genotyping
T37993	39655-39660	VBN	denotes	shown
T37994	39631-39633	IN	denotes	of
T37995	39634-39636	DT	denotes	an
T37996	39646-39651	NN	denotes	mouse
T37997	39637-39642	NN	denotes	E2f3a
T37998	39642-39643	SYM	denotes	+
T37999	39643-39644	HYPH	denotes	/
T38000	39644-39645	SYM	denotes	−
T38001	39652-39654	VBZ	denotes	is
T38002	39661-39663	IN	denotes	on
T38003	39664-39667	DT	denotes	the
T38004	39668-39673	NN	denotes	right
T38005	39673-39674	.	denotes	.
T38006	39674-39734	sentence	denotes	(B) RT-PCR detection of E2f3a and E2f3b mRNA in the retina.
T38007	39675-39676	-LRB-	denotes	(
T38008	39676-39677	LS	denotes	B
T38009	39686-39695	NN	denotes	detection
T38010	39677-39678	-RRB-	denotes	)
T38011	39679-39681	NN	denotes	RT
T38012	39682-39685	NN	denotes	PCR
T38013	39681-39682	HYPH	denotes	-
T38014	39696-39698	IN	denotes	of
T38015	39699-39704	NN	denotes	E2f3a
T38016	39715-39719	NN	denotes	mRNA
T38017	39705-39708	CC	denotes	and
T38018	39709-39714	NN	denotes	E2f3b
T38019	39720-39722	IN	denotes	in
T38020	39723-39726	DT	denotes	the
T38021	39727-39733	NN	denotes	retina
T38022	39733-39734	.	denotes	.
T38023	39734-39868	sentence	denotes	The sequences of primers are 1aF (5′-GCCTCTACACCACGCCACAAG-3′), 1bF (5′-CGGAAATGCCCTTACAGC-3′), and 4R (5′-CTCAGTCACTTCTTTGGACAG-3′).
T38024	39735-39738	DT	denotes	The
T38025	39739-39748	NNS	denotes	sequences
T38026	39760-39763	VBP	denotes	are
T38027	39749-39751	IN	denotes	of
T38028	39752-39759	NNS	denotes	primers
T38029	39764-39767	NN	denotes	1aF
T38030	39768-39769	-LRB-	denotes	(
T38031	39769-39770	CD	denotes	5
T38032	39772-39793	NN	denotes	GCCTCTACACCACGCCACAAG
T38033	39770-39771	SYM	denotes	′
T38034	39771-39772	HYPH	denotes	-
T38035	39793-39794	HYPH	denotes	-
T38036	39794-39795	CD	denotes	3
T38037	39795-39796	SYM	denotes	′
T38038	39796-39797	-RRB-	denotes	)
T38039	39797-39799	,	denotes	,
T38040	39799-39802	NN	denotes	1bF
T38041	39803-39804	-LRB-	denotes	(
T38042	39804-39805	CD	denotes	5
T38043	39807-39825	NN	denotes	CGGAAATGCCCTTACAGC
T38044	39805-39806	SYM	denotes	′
T38045	39806-39807	HYPH	denotes	-
T38046	39825-39826	HYPH	denotes	-
T38047	39826-39827	CD	denotes	3
T38048	39827-39828	SYM	denotes	′
T38049	39828-39829	-RRB-	denotes	)
T38050	39829-39831	,	denotes	,
T38051	39831-39834	CC	denotes	and
T38052	39835-39837	NN	denotes	4R
T38053	39838-39839	-LRB-	denotes	(
T38054	39839-39840	CD	denotes	5
T38055	39842-39863	NN	denotes	CTCAGTCACTTCTTTGGACAG
T38056	39840-39841	SYM	denotes	′
T38057	39841-39842	HYPH	denotes	-
T38058	39863-39864	HYPH	denotes	-
T38059	39864-39865	CD	denotes	3
T38060	39865-39866	SYM	denotes	′
T38061	39866-39867	-RRB-	denotes	)
T38062	39867-39868	.	denotes	.
T38063	39868-39915	sentence	denotes	WT retina expresses both E2f3a and E2f3b mRNA.
T38064	39869-39871	NN	denotes	WT
T38065	39872-39878	NN	denotes	retina
T38066	39879-39888	VBZ	denotes	expresses
T38067	39889-39893	CC	denotes	both
T38068	39894-39899	NN	denotes	E2f3a
T38069	39910-39914	NN	denotes	mRNA
T38070	39900-39903	CC	denotes	and
T38071	39904-39909	NN	denotes	E2f3b
T38072	39914-39915	.	denotes	.
T38073	39915-39993	sentence	denotes	As expected, E2f3a−/− retina lacks E2f3a mRNA and still expresses E2f3b mRNA.
T38074	39916-39918	IN	denotes	As
T38075	39919-39927	VBN	denotes	expected
T38076	39945-39950	VBZ	denotes	lacks
T38077	39927-39929	,	denotes	,
T38078	39929-39934	NN	denotes	E2f3a
T38079	39938-39944	NN	denotes	retina
T38080	39934-39935	SYM	denotes	−
T38081	39935-39936	HYPH	denotes	/
T38082	39936-39937	SYM	denotes	−
T38083	39951-39956	NN	denotes	E2f3a
T38084	39957-39961	NN	denotes	mRNA
T38085	39962-39965	CC	denotes	and
T38086	39966-39971	RB	denotes	still
T38087	39972-39981	VBZ	denotes	expresses
T38088	39982-39987	NN	denotes	E2f3b
T38089	39988-39992	NN	denotes	mRNA
T38090	39992-39993	.	denotes	.
T38091	39993-40104	sentence	denotes	E2f3−/− retina lacks full-length E2f3a and E2f3b mRNAs, and instead expresses a truncated mRNA lacking exon 3.
T38092	39994-39998	NN	denotes	E2f3
T38093	40002-40008	NN	denotes	retina
T38094	39998-39999	SYM	denotes	−
T38095	39999-40000	HYPH	denotes	/
T38096	40000-40001	SYM	denotes	−
T38097	40009-40014	VBZ	denotes	lacks
T38098	40015-40019	JJ	denotes	full
T38099	40020-40026	NN	denotes	length
T38100	40019-40020	HYPH	denotes	-
T38101	40043-40048	NNS	denotes	mRNAs
T38102	40027-40032	NN	denotes	E2f3a
T38103	40033-40036	CC	denotes	and
T38104	40037-40042	NN	denotes	E2f3b
T38105	40048-40050	,	denotes	,
T38106	40050-40053	CC	denotes	and
T38107	40054-40061	RB	denotes	instead
T38108	40062-40071	VBZ	denotes	expresses
T38109	40072-40073	DT	denotes	a
T38110	40084-40088	NN	denotes	mRNA
T38111	40074-40083	VBN	denotes	truncated
T38112	40089-40096	VBG	denotes	lacking
T38113	40097-40101	NN	denotes	exon
T38114	40102-40103	CD	denotes	3
T38115	40103-40104	.	denotes	.
T38116	40104-40189	sentence	denotes	(C) Real-time RT-PCR analysis of E2f genes in P8 retinas of the indicated genotypes.
T38117	40105-40106	-LRB-	denotes	(
T38118	40106-40107	LS	denotes	C
T38119	40126-40134	NN	denotes	analysis
T38120	40107-40108	-RRB-	denotes	)
T38121	40109-40113	JJ	denotes	Real
T38122	40114-40118	NN	denotes	time
T38123	40113-40114	HYPH	denotes	-
T38124	40119-40121	NN	denotes	RT
T38125	40122-40125	NN	denotes	PCR
T38126	40121-40122	HYPH	denotes	-
T38127	40135-40137	IN	denotes	of
T38128	40138-40141	NN	denotes	E2f
T38129	40142-40147	NNS	denotes	genes
T38130	40148-40150	IN	denotes	in
T38131	40151-40153	NN	denotes	P8
T38132	40154-40161	NNS	denotes	retinas
T38133	40162-40164	IN	denotes	of
T38134	40165-40168	DT	denotes	the
T38135	40179-40188	NNS	denotes	genotypes
T38136	40169-40178	VBN	denotes	indicated
T38137	40188-40189	.	denotes	.
T38138	40189-40389	sentence	denotes	Error bars represent SD of measurements from three animals, and asterisks indicate a significant difference between WT and the indicated genotypes (, p <0.05; *; p <0.01; ANOVA and Tukey HSD test).
T38139	40190-40195	NN	denotes	Error
T38140	40196-40200	NNS	denotes	bars
T38141	40201-40210	VBP	denotes	represent
T38142	40211-40213	NN	denotes	SD
T38143	40214-40216	IN	denotes	of
T38144	40217-40229	NNS	denotes	measurements
T38145	40230-40234	IN	denotes	from
T38146	40235-40240	CD	denotes	three
T38147	40241-40248	NNS	denotes	animals
T38148	40248-40250	,	denotes	,
T38149	40250-40253	CC	denotes	and
T38150	40254-40263	NNS	denotes	asterisks
T38151	40264-40272	VBP	denotes	indicate
T38152	40273-40274	DT	denotes	a
T38153	40287-40297	NN	denotes	difference
T38154	40275-40286	JJ	denotes	significant
T38155	40298-40305	IN	denotes	between
T38156	40306-40308	NN	denotes	WT
T38157	40309-40312	CC	denotes	and
T38158	40313-40316	DT	denotes	the
T38159	40317-40326	VBN	denotes	indicated
T38160	40327-40336	NNS	denotes	genotypes
T38161	40337-40338	-LRB-	denotes	(
T38162	40383-40387	NN	denotes	test
T38163	40338-40339	SYM	denotes	*
T38164	40344-40348	CD	denotes	0.05
T38165	40339-40341	,	denotes	,
T38166	40341-40342	NN	denotes	p
T38167	40343-40344	SYM	denotes	<
T38168	40348-40349	:	denotes	;
T38169	40350-40352	SYM	denotes	**
T38170	40357-40361	CD	denotes	0.01
T38171	40352-40353	:	denotes	;
T38172	40354-40355	NN	denotes	p
T38173	40356-40357	SYM	denotes	<
T38174	40361-40362	:	denotes	;
T38175	40363-40368	NN	denotes	ANOVA
T38176	40369-40372	CC	denotes	and
T38177	40373-40378	NNP	denotes	Tukey
T38178	40379-40382	NN	denotes	HSD
T38179	40387-40388	-RRB-	denotes	)
T38180	40388-40389	.	denotes	.
T38181	40389-40433	sentence	denotes	(D) Rescue of Rb KO SACs by E2f3a deletion.
T38182	40390-40391	-LRB-	denotes	(
T38183	40391-40392	LS	denotes	D
T38184	40394-40400	NN	denotes	Rescue
T38185	40392-40393	-RRB-	denotes	)
T38186	40401-40403	IN	denotes	of
T38187	40404-40406	NN	denotes	Rb
T38188	40407-40409	NN	denotes	KO
T38189	40410-40414	NNS	denotes	SACs
T38190	40415-40417	IN	denotes	by
T38191	40418-40423	NN	denotes	E2f3a
T38192	40424-40432	NN	denotes	deletion
T38193	40432-40433	.	denotes	.
T38194	40433-40591	sentence	denotes	Horizontal retinal sections of the indicated genotypes and ages were stained for nuclei (DAPI, blue), M-phase (PH3, green), and the SAC marker Slc18a3 (red).
T38195	40434-40444	JJ	denotes	Horizontal
T38196	40453-40461	NNS	denotes	sections
T38197	40445-40452	JJ	denotes	retinal
T38198	40503-40510	VBN	denotes	stained
T38199	40462-40464	IN	denotes	of
T38200	40465-40468	DT	denotes	the
T38201	40479-40488	NNS	denotes	genotypes
T38202	40469-40478	VBN	denotes	indicated
T38203	40489-40492	CC	denotes	and
T38204	40493-40497	NNS	denotes	ages
T38205	40498-40502	VBD	denotes	were
T38206	40511-40514	IN	denotes	for
T38207	40515-40521	NNS	denotes	nuclei
T38208	40522-40523	-LRB-	denotes	(
T38209	40529-40533	JJ	denotes	blue
T38210	40523-40527	NN	denotes	DAPI
T38211	40527-40529	,	denotes	,
T38212	40533-40534	-RRB-	denotes	)
T38213	40534-40536	,	denotes	,
T38214	40536-40537	NN	denotes	M
T38215	40538-40543	NN	denotes	phase
T38216	40537-40538	HYPH	denotes	-
T38217	40544-40545	-LRB-	denotes	(
T38218	40550-40555	JJ	denotes	green
T38219	40545-40548	NN	denotes	PH3
T38220	40548-40550	,	denotes	,
T38221	40555-40556	-RRB-	denotes	)
T38222	40556-40558	,	denotes	,
T38223	40558-40561	CC	denotes	and
T38224	40562-40565	DT	denotes	the
T38225	40570-40576	NN	denotes	marker
T38226	40566-40569	NN	denotes	SAC
T38227	40577-40584	NN	denotes	Slc18a3
T38228	40585-40586	-LRB-	denotes	(
T38229	40586-40589	JJ	denotes	red
T38230	40589-40590	-RRB-	denotes	)
T38231	40590-40591	.	denotes	.
T38232	40591-40670	sentence	denotes	E2f3a deletion does not suppress ectopic division, but rescues the SAC defect.
T38233	40592-40597	NN	denotes	E2f3a
T38234	40598-40606	NN	denotes	deletion
T38235	40616-40624	VB	denotes	suppress
T38236	40607-40611	VBZ	denotes	does
T38237	40612-40615	RB	denotes	not
T38238	40625-40632	JJ	denotes	ectopic
T38239	40633-40641	NN	denotes	division
T38240	40641-40643	,	denotes	,
T38241	40643-40646	CC	denotes	but
T38242	40647-40654	VBZ	denotes	rescues
T38243	40655-40658	DT	denotes	the
T38244	40663-40669	NN	denotes	defect
T38245	40659-40662	NN	denotes	SAC
T38246	40669-40670	.	denotes	.
T38247	40670-40692	sentence	denotes	Scale bars are 50 μm.
T38248	40671-40676	NN	denotes	Scale
T38249	40677-40681	NNS	denotes	bars
T38250	40682-40685	VBP	denotes	are
T38251	40686-40688	CD	denotes	50
T38252	40689-40691	NN	denotes	μm
T38253	40691-40692	.	denotes	.
T38254	40692-40718	sentence	denotes	M, molecular size marker.
T38255	40693-40694	NN	denotes	M
T38256	40694-40696	,	denotes	,
T38257	40696-40705	JJ	denotes	molecular
T38258	40706-40710	NN	denotes	size
T38259	40711-40717	NN	denotes	marker
T38260	40717-40718	.	denotes	.
T38541	47006-47008	NN	denotes	Rb
T38542	47009-47018	VBZ	denotes	Regulates
T38543	47019-47027	JJ	denotes	Distinct
T38544	47028-47037	NNS	denotes	Processes
T38545	47038-47045	IN	denotes	through
T38546	47046-47050	NN	denotes	E2f1
T38547	47051-47054	CC	denotes	and
T38548	47055-47060	NN	denotes	E2f3a
T38549	47060-47110	sentence	denotes	Red text and arrows indicate Rb-dependent events.
T38550	47061-47064	JJ	denotes	Red
T38551	47065-47069	NN	denotes	text
T38552	47081-47089	VBP	denotes	indicate
T38553	47070-47073	CC	denotes	and
T38554	47074-47080	NNS	denotes	arrows
T38555	47090-47092	NN	denotes	Rb
T38556	47093-47102	JJ	denotes	dependent
T38557	47092-47093	HYPH	denotes	-
T38558	47103-47109	NNS	denotes	events
T38559	47109-47110	.	denotes	.
T38560	47110-47205	sentence	denotes	Black text and arrows indicate events for which there is no direct evidence of Rb involvement.
T38561	47111-47116	JJ	denotes	Black
T38562	47117-47121	NN	denotes	text
T38563	47133-47141	VBP	denotes	indicate
T38564	47122-47125	CC	denotes	and
T38565	47126-47132	NNS	denotes	arrows
T38566	47142-47148	NNS	denotes	events
T38567	47149-47152	IN	denotes	for
T38568	47165-47167	VBZ	denotes	is
T38569	47153-47158	WDT	denotes	which
T38570	47159-47164	EX	denotes	there
T38571	47168-47170	DT	denotes	no
T38572	47178-47186	NN	denotes	evidence
T38573	47171-47177	JJ	denotes	direct
T38574	47187-47189	IN	denotes	of
T38575	47190-47192	NN	denotes	Rb
T38576	47193-47204	NN	denotes	involvement
T38577	47204-47205	.	denotes	.
T38578	47205-47397	sentence	denotes	Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle.
T38579	47206-47208	NN	denotes	Rb
T38580	47218-47224	VB	denotes	appear
T38581	47209-47213	VBZ	denotes	does
T38582	47214-47217	RB	denotes	not
T38583	47225-47227	TO	denotes	to
T38584	47228-47234	VB	denotes	temper
T38585	47235-47238	NN	denotes	RPC
T38586	47239-47248	NN	denotes	expansion
T38587	47249-47252	CC	denotes	and
T38588	47253-47255	VBZ	denotes	is
T38589	47260-47268	VBN	denotes	required
T38590	47256-47259	RB	denotes	not
T38591	47269-47272	IN	denotes	for
T38592	47273-47288	NN	denotes	differentiation
T38593	47289-47291	IN	denotes	of
T38594	47292-47296	NNS	denotes	RPCs
T38595	47297-47301	IN	denotes	into
T38596	47302-47306	NNS	denotes	RTCs
T38597	47306-47308	,	denotes	,
T38598	47308-47311	CC	denotes	but
T38599	47312-47314	VBZ	denotes	is
T38600	47315-47324	JJ	denotes	essential
T38601	47325-47327	TO	denotes	to
T38602	47328-47334	VB	denotes	couple
T38603	47335-47338	NN	denotes	RTC
T38604	47339-47344	NN	denotes	birth
T38605	47345-47347	IN	denotes	to
T38606	47348-47356	JJ	denotes	terminal
T38607	47357-47364	NN	denotes	mitosis
T38608	47364-47366	,	denotes	,
T38609	47366-47370	RB	denotes	thus
T38610	47371-47378	VBG	denotes	locking
T38611	47379-47383	PRP	denotes	them
T38612	47384-47387	RB	denotes	out
T38613	47388-47390	IN	denotes	of
T38614	47391-47396	NN	denotes	cycle
T38615	47396-47397	.	denotes	.
T38616	47397-47443	sentence	denotes	Rb performs this function by inhibiting E2f1.
T38617	47398-47400	NN	denotes	Rb
T38618	47401-47409	VBZ	denotes	performs
T38619	47410-47414	DT	denotes	this
T38620	47415-47423	NN	denotes	function
T38621	47424-47426	IN	denotes	by
T38622	47427-47437	VBG	denotes	inhibiting
T38623	47438-47442	NN	denotes	E2f1
T38624	47442-47443	.	denotes	.
T38625	47443-47532	sentence	denotes	Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a.
T38626	47444-47446	NN	denotes	Rb
T38627	47455-47463	VBN	denotes	required
T38628	47447-47449	VBZ	denotes	is
T38629	47450-47454	RB	denotes	also
T38630	47464-47467	IN	denotes	for
T38631	47468-47471	NN	denotes	SAC
T38632	47472-47487	NN	denotes	differentiation
T38633	47487-47489	,	denotes	,
T38634	47489-47492	CC	denotes	and
T38635	47493-47495	IN	denotes	in
T38636	47507-47511	VBZ	denotes	acts
T38637	47496-47500	DT	denotes	this
T38638	47501-47505	NN	denotes	case
T38639	47505-47507	,	denotes	,
T38640	47512-47514	IN	denotes	by
T38641	47515-47525	VBG	denotes	inhibiting
T38642	47526-47531	NN	denotes	E2f3a
T38643	47531-47532	.	denotes	.
T38644	47532-47630	sentence	denotes	There is no direct evidence that Rb is required for terminal differentiation of other cell types.
T38645	47533-47538	EX	denotes	There
T38646	47539-47541	VBZ	denotes	is
T38647	47542-47544	DT	denotes	no
T38648	47552-47560	NN	denotes	evidence
T38649	47545-47551	JJ	denotes	direct
T38650	47561-47565	IN	denotes	that
T38651	47572-47580	VBN	denotes	required
T38652	47566-47568	NN	denotes	Rb
T38653	47569-47571	VBZ	denotes	is
T38654	47581-47584	IN	denotes	for
T38655	47585-47593	JJ	denotes	terminal
T38656	47594-47609	NN	denotes	differentiation
T38657	47610-47612	IN	denotes	of
T38658	47613-47618	JJ	denotes	other
T38659	47624-47629	NNS	denotes	types
T38660	47619-47623	NN	denotes	cell
T38661	47629-47630	.	denotes	.
T38662	47630-47678	sentence	denotes	Colour codes and abbreviations as in Figure 1A.
T38663	47631-47637	NN	denotes	Colour
T38664	47638-47643	NNS	denotes	codes
T38665	47644-47647	CC	denotes	and
T38666	47648-47661	NNS	denotes	abbreviations
T38667	47662-47664	IN	denotes	as
T38668	47665-47667	IN	denotes	in
T38669	47668-47674	NN	denotes	Figure
T38670	47675-47677	NN	denotes	1A
T38671	47677-47678	.	denotes	.
T24729	46657-46665	JJ	denotes	specific
T24730	46656-46657	HYPH	denotes	-
T24731	46680-46687	NNS	denotes	factors
T24732	46666-46679	NN	denotes	transcription
T24733	46688-46692	WDT	denotes	that
T24734	46693-46700	VBP	denotes	promote
T24735	46701-46716	NN	denotes	differentiation
T24736	46717-46718	-LRB-	denotes	[
T24737	46718-46720	CD	denotes	31
T24814	47718-47719	EX	denotes	r
T24815	47719-47720	DT	denotes	o
T24816	47720-47721	VBN	denotes	u
T24817	47721-47722	sentence	denotes	g
T24818	47721-47722	NN	denotes	g
T24821	47722-47723	IN	denotes	h
T24822	47724-47728	NN	denotes	E2f3
T24823	47805-47812	VBD	denotes	rescued
T24824	47733-47744	JJ	denotes	independent
T24825	47745-47747	IN	denotes	of
T18728	34794-34795	-RRB-	denotes	)
T18729	34795-34796	.	denotes	.
T18730	34796-34968	sentence	denotes	These data suggest that Rb and E2f3 colocalize in SACs and that E2f3 triggers defects in SAC differentiation because it is specifically expressed in these retinal neurons.
T18731	34797-34802	DT	denotes	These
T18732	34803-34807	NNS	denotes	data
T18733	34808-34815	VBP	denotes	suggest
T18734	34816-34820	IN	denotes	that
T18735	34833-34843	VBP	denotes	colocalize
T18736	34821-34823	NN	denotes	Rb
T18737	34824-34827	CC	denotes	and
T18738	34828-34832	NN	denotes	E2f3
T18739	34844-34846	IN	denotes	in
T18740	34847-34851	NNS	denotes	SACs
T18741	34852-34855	CC	denotes	and
T18742	34856-34860	IN	denotes	that
T18743	34866-34874	VBZ	denotes	triggers
T18744	34861-34865	NN	denotes	E2f3
T18745	34875-34882	NNS	denotes	defects
T18746	34883-34885	IN	denotes	in
T18747	34886-34889	NN	denotes	SAC
T18748	34890-34905	NN	denotes	differentiation
T18749	34906-34913	IN	denotes	because
T18750	34933-34942	VBN	denotes	expressed
T18751	34914-34916	PRP	denotes	it
T18752	34917-34919	VBZ	denotes	is
T18753	34920-34932	RB	denotes	specifically
T18754	34943-34945	IN	denotes	in
T18755	34946-34951	DT	denotes	these
T18756	34960-34967	NNS	denotes	neurons
T18757	34952-34959	JJ	denotes	retinal
T18758	34967-34968	.	denotes	.
T18770	35814-35822	JJ	denotes	specific
T18771	35830-35832	IN	denotes	of
T18772	35833-35839	JJ	denotes	mature
T18773	35840-35847	NNS	denotes	neurons
T18774	35848-35850	IN	denotes	in
T18775	35851-35858	JJ	denotes	various
T18776	35865-35872	NNS	denotes	regions
T18777	35859-35864	NN	denotes	brain
T18778	35873-35874	-LRB-	denotes	(
T20626	38625-38629	NNS	denotes	data
T20627	38630-38634	VBP	denotes	show
T20628	38634-38636	,	denotes	,
T20629	38636-38638	IN	denotes	to
T20630	38653-38656	IN	denotes	for
T20631	38639-38642	PRP$	denotes	our
T20632	38643-38652	NN	denotes	knowledge
T20633	38657-38660	DT	denotes	the
T20634	38667-38671	NN	denotes	time
T20635	38661-38666	JJ	denotes	first
T20636	38671-38673	,	denotes	,
T20637	38673-38677	IN	denotes	that
T20638	38694-38701	VBP	denotes	exhibit
T20639	38678-38683	NN	denotes	E2f3a
T20640	38684-38687	CC	denotes	and
T20641	38688-38693	NN	denotes	E2f3b
T20642	38702-38710	JJ	denotes	distinct
T20643	38711-38719	NNS	denotes	patterns
T20644	38720-38722	IN	denotes	of
T20645	38723-38734	JJ	denotes	subcellular
T20646	38735-38747	NN	denotes	distribution
T20647	38747-38749	,	denotes	,
T20648	38749-38752	CC	denotes	and
T20649	38753-38758	VB	denotes	raise
T20650	38759-38762	DT	denotes	the
T20651	38763-38774	NN	denotes	possibility
T20652	38775-38779	IN	denotes	that
T20653	38806-38815	VBN	denotes	regulated
T20654	38780-38785	NN	denotes	E2f3a
T20655	38786-38798	NN	denotes	localization
T20656	38799-38802	MD	denotes	may
T20657	38803-38805	VB	denotes	be
T20658	38816-38818	IN	denotes	by
T20659	38819-38821	RB	denotes	as
T20660	38822-38825	RB	denotes	yet
T20661	38826-38833	JJ	denotes	unknown
T20662	38853-38866	NNS	denotes	modifications
T20663	38834-38852	JJ	denotes	post-translational
T20664	38866-38867	.	denotes	.
T20695	40879-40881	NN	denotes	P0
T20696	40881-40883	,	denotes	,
T20697	40883-40886	CC	denotes	but
T20698	40887-40889	IN	denotes	at
T20699	40935-40938	VBD	denotes	was
T20700	40890-40893	NN	denotes	P18
T20701	40893-40895	,	denotes	,
T20702	40895-40899	WRB	denotes	when
T20703	40921-40930	VBN	denotes	increased
T20704	40900-40903	DT	denotes	the
T32553	61368-61378	NNS	denotes	Statistics
T32554	61378-61379	.	denotes	.
T32555	61379-61570	sentence	denotes	Different genotypes were evaluated using analysis of variance (ANOVA) followed by the Tukey honestly significant difference (HSD) test or Fisher test (XLSTAT program, http://www.xlstat.com).
T32556	61380-61389	JJ	denotes	Different
T32557	61390-61399	NNS	denotes	genotypes
T32558	61405-61414	VBN	denotes	evaluated
T32559	61400-61404	VBD	denotes	were
T32560	61415-61420	VBG	denotes	using
T32561	61421-61429	NN	denotes	analysis
T32562	61430-61432	IN	denotes	of
T32563	61433-61441	NN	denotes	variance
T32564	61442-61443	-LRB-	denotes	(
T32565	61443-61448	NN	denotes	ANOVA
T32566	61448-61449	-RRB-	denotes	)
T32567	61450-61458	VBN	denotes	followed
T32568	61459-61461	IN	denotes	by
T32569	61462-61465	DT	denotes	the
T32570	61510-61514	NN	denotes	test
T20705	40904-40910	NNS	denotes	levels
T20706	40911-40913	IN	denotes	of
T20707	40914-40916	NN	denotes	Rb
T20708	40917-40920	VBD	denotes	had
T20709	40930-40932	,	denotes	,
T20710	40932-40934	PRP	denotes	it
T20711	40939-40948	RB	denotes	primarily
T20712	40949-40956	JJ	denotes	nuclear
T20713	40957-40958	-LRB-	denotes	(
T20714	40958-40964	NN	denotes	Figure
T20715	40965-40966	CD	denotes	6
T623	0-2	NN	denotes	Rb
T624	3-11	VBN	denotes	Mediated
T13975	24489-24492	sentence	denotes	f t
T13976	24489-24490	IN	denotes	f
T13977	24491-24492	NN	denotes	t
T24717	46586-46594	JJ	denotes	skeletal
T24718	46595-46601	NN	denotes	muscle
T24719	46601-46603	,	denotes	,
T24720	46603-46613	NNS	denotes	adipocytes
T24721	46613-46615	,	denotes	,
T24722	46615-46618	CC	denotes	and
T24723	46619-46623	NN	denotes	bone
T24724	46623-46625	,	denotes	,
T24725	46625-46627	PRP	denotes	it
T24726	46634-46637	CC	denotes	and
T24727	46638-46649	VBZ	denotes	potentiates
T24728	46650-46656	NN	denotes	tissue
T24800	47012-47696	sentence	denotes	ulates Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulation of
T24801	47012-47013	VBN	denotes	u
T24802	47013-47014	JJ	denotes	l
T24803	47014-47015	JJ	denotes	a
T24804	47015-47690	NN	denotes	tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati
T24805	47690-47692	VBG	denotes	on
T24806	47693-47694	RB	denotes	o
T24807	47694-47695	IN	denotes	f
T24808	47696-47718	sentence	denotes	SAC differentiation th
T24809	47696-47699	NN	denotes	SAC
T24810	47700-47715	NN	denotes	differentiation
T24811	47715-47716	,	denotes
T24812	47716-47718	DT	denotes	th
T24813	47718-47721	sentence	denotes	rou
T24819	47722-47988	sentence	denotes	h E2f3 was independent of its role in controlling division or death: E2f3 deletion rescued Rb KO SAC defects but did not suppress aberrant proliferation or death, whereas E2f1 deletion reversed abnormal proliferation and death but did not rescue SAC differentiation.
T24820	47729-47732	VBD	denotes	was
T13978	24492-24500	sentence	denotes	he three
T18716	34752-34758	NN	denotes	retina
T18717	34741-34751	JJ	denotes	peripheral
T18718	34759-34761	IN	denotes	of
T18719	34762-34766	NN	denotes	αCre
T18720	34774-34778	NN	denotes	loxP
T18721	34766-34767	:	denotes	;
T18722	34767-34773	NN	denotes	RbloxP
T18723	34773-34774	HYPH	denotes	/
T18724	34779-34783	NNS	denotes	mice
T18725	34784-34785	-LRB-	denotes	(
T18726	34792-34794	NN	denotes	5A
T18727	34785-34791	NN	denotes	Figure
T18759	34968-35890	sentence	denotes	Figure 5 E2f3 and Rb Expression in SACs (A) Left panels: horizontal P0, P8, and P18 retinal sections of the indicated genotypes were stained for E2f3 (red) and DAPI (blue). The arrow indicates the junction between the E2f3 null peripheral and WT central P0 retina. Note the absence of E2f3 protein in the peripheral E2f3 KO RPCs at P0 and in peripheral inner retinal neurons at P18. Far right panel: P18 retinal sections of the indicated genotypes were stained for Rb (red) and DAPI (blue). Note the absence of Rb protein in the peripheral Rb KO inner retinal neurons. (B) WT P18 retinal sections were stained for nuclei (DAPI, blue), E2f3 (red) or Rb (red), and Chat plus Slc18a3 (green). Arrows indicate double-labelled soma. Note that the IPL processes are also double-labelled. Scale bars are 50 μm. We also found that E2f3 is present in a specific subset of mature neurons in various brain regions (data not shown).
T18760	35774-35776	PRP	denotes	We
T18761	35782-35787	VBD	denotes	found
T18762	35777-35781	RB	denotes	also
T18763	35788-35792	IN	denotes	that
T18764	35798-35800	VBZ	denotes	is
T18765	35793-35797	NN	denotes	E2f3
T18766	35801-35808	JJ	denotes	present
T18767	35809-35811	IN	denotes	in
T18768	35812-35813	DT	denotes	a
T18769	35823-35829	NN	denotes	subset
T13979	24493-24494	NNS	denotes	e
T13980	24492-24493	JJ	denotes	h
T13981	24495-24496	NN	denotes	t
T13993	24509-24510	NN	denotes	r
T20409	37569-37570	.	denotes	.
T20620	38608-38614	NN	denotes	Figure
T20621	38615-38616	CD	denotes	6
T20622	38616-38617	-RRB-	denotes	)
T20623	38617-38618	.	denotes	.
T20624	38618-38867	sentence	denotes	These data show, to our knowledge for the first time, that E2f3a and E2f3b exhibit distinct patterns of subcellular distribution, and raise the possibility that E2f3a localization may be regulated by as yet unknown post-translational modifications.
T20625	38619-38624	DT	denotes	These
T13994	24510-24511	NNS	denotes	a
T20665	38867-40811	sentence	denotes	Figure 6 Subcellular Distribution of E2f3 Isoforms and Other Cell Cycle Proteins in the Developing Retina Nuclear and cytoplasmic extracts from an equivalent number of retinal cells from mice of the indicated genotypes and ages were analyzed by Western blotting to detect the indicated proteins. Lysate from E2f3a−/− mice was used as a control to confirm the location of E2f3a protein. C, cytoplasmic extracts; N, nuclear extracts. Figure 7 The E2f3a Isoform Drives the Differentiation Defect in Rb KO SACs (A) Schematic diagrams of the mouse WT, E2f3a−/−, and the Cre-recombined floxed E2f3 loci (indicated here as E2f3−/− for simplicity). E2f3a−/− mice lack most of E2f3 exon 1a and part of intron 1a (red dotted box). Arrows indicate PCR primers. Genotyping of an E2f3a+/− mouse is shown on the right. (B) RT-PCR detection of E2f3a and E2f3b mRNA in the retina. The sequences of primers are 1aF (5′-GCCTCTACACCACGCCACAAG-3′), 1bF (5′-CGGAAATGCCCTTACAGC-3′), and 4R (5′-CTCAGTCACTTCTTTGGACAG-3′). WT retina expresses both E2f3a and E2f3b mRNA. As expected, E2f3a−/− retina lacks E2f3a mRNA and still expresses E2f3b mRNA. E2f3−/− retina lacks full-length E2f3a and E2f3b mRNAs, and instead expresses a truncated mRNA lacking exon 3. (C) Real-time RT-PCR analysis of E2f genes in P8 retinas of the indicated genotypes. Error bars represent SD of measurements from three animals, and asterisks indicate a significant difference between WT and the indicated genotypes (, p <0.05; *; p <0.01; ANOVA and Tukey HSD test). (D) Rescue of Rb KO SACs by E2f3a deletion. Horizontal retinal sections of the indicated genotypes and ages were stained for nuclei (DAPI, blue), M-phase (PH3, green), and the SAC marker Slc18a3 (red). E2f3a deletion does not suppress ectopic division, but rescues the SAC defect. Scale bars are 50 μm. M, molecular size marker. We also examined the distribution of other cell cycle regulators during retinal development.
T20666	40719-40721	PRP	denotes	We
T20667	40727-40735	VBD	denotes	examined
T20668	40722-40726	RB	denotes	also
T20669	40736-40739	DT	denotes	the
T20670	40740-40752	NN	denotes	distribution
T20671	40753-40755	IN	denotes	of
T20672	40756-40761	JJ	denotes	other
T20673	40773-40783	NNS	denotes	regulators
T20674	40762-40766	NN	denotes	cell
T20675	40767-40772	NN	denotes	cycle
T20676	40784-40790	IN	denotes	during
T20677	40791-40798	JJ	denotes	retinal
T20678	40799-40810	NN	denotes	development
T20679	40810-40811	.	denotes	.
T20680	40811-40968	sentence	denotes	Like E2f3a, Rb was present in both the WT cytoplasm and nucleus at P0, but at P18, when the levels of Rb had increased, it was primarily nuclear (Figure 6).
T20681	40812-40816	IN	denotes	Like
T20682	40827-40830	VBD	denotes	was
T20683	40817-40822	NN	denotes	E2f3a
T20684	40822-40824	,	denotes	,
T20685	40824-40826	NN	denotes	Rb
T20686	40831-40838	JJ	denotes	present
T20687	40839-40841	IN	denotes	in
T20688	40842-40846	CC	denotes	both
T20689	40854-40863	NN	denotes	cytoplasm
T20690	40847-40850	DT	denotes	the
T20691	40851-40853	NN	denotes	WT
T20692	40864-40867	CC	denotes	and
T20693	40868-40875	NN	denotes	nucleus
T20694	40876-40878	IN	denotes	at
T13995	24511-24512	VBP	denotes	c
T13996	24513-24514	NN	denotes	s
T14029	24637-24648	JJ	denotes	cholinergic
T7556	14493-14617	sentence	denotes	Deleting E2f1, but not E2f2 or E2f3, blocked this ectopic cell death in a dose-dependent fashion (Figures 1D, 1G, and S1B).
T7557	14494-14502	VBG	denotes	Deleting
T7558	14531-14538	VBD	denotes	blocked
T7559	14503-14507	NN	denotes	E2f1
T7560	14507-14509	,	denotes	,
T7561	14509-14512	CC	denotes	but
T7562	14513-14516	RB	denotes	not
T7563	14517-14521	NN	denotes	E2f2
T7564	14522-14524	CC	denotes	or
T7565	14525-14529	NN	denotes	E2f3
T7566	14529-14531	,	denotes	,
T7567	14539-14543	DT	denotes	this
T7568	14557-14562	NN	denotes	death
T7569	14544-14551	JJ	denotes	ectopic
T7570	14552-14556	NN	denotes	cell
T7571	14563-14565	IN	denotes	in
T7572	14566-14567	DT	denotes	a
T7573	14583-14590	NN	denotes	fashion
T7574	14568-14572	NN	denotes	dose
T7575	14573-14582	JJ	denotes	dependent
T7576	14572-14573	HYPH	denotes	-
T7577	14591-14592	-LRB-	denotes	(
T7578	14600-14602	NN	denotes	1D
T7579	14592-14599	NNS	denotes	Figures
T7580	14602-14604	,	denotes	,
T7581	14604-14606	NN	denotes	1G
T7582	14606-14608	,	denotes	,
T7583	14608-14611	CC	denotes	and
T7584	14612-14615	NN	denotes	S1B
T7585	14615-14616	-RRB-	denotes	)
T7586	14616-14617	.	denotes	.
T7587	14617-16132	sentence	denotes	Figure 2 E2f1 Deletion Rescues Ganglion, Rod, and Bipolar Cells in the Rb KO Retina (A) Horizontal retinal sections from mice of the indicated ages and genotypes were stained for nuclei (DAPI, blue) and markers that detect ganglion cells (Pou4f2, red), rods and cones (Sag [rod arrestin], green), and rod bipolar cells (Prkca, green, and Cabp5, red). Scale bars are 50 μm. (B) Quantification of Pou4f2+ ganglion cells. (C) Quantification of Prkca+ and Cabp5+ bipolar cells. (D) Thickness of the ONL, which represents the number of rods. Error bars represent SD of measurements from three animals, and asterisks indicate a significant difference between retinas of WT and the indicated genotypes, unless indicated otherwise by connecting lines (, p < 0.05; *; p < 0.01; ANOVA and Tukey HSD test). (E and F) ERGs were recorded from the indicated genotypes under dark-adapted (scotopic) conditions, and (E) intensity series and (F) b-wave amplitudes as a function of the logarithm of the flash intensity were determined. (F) Further illustrates that the relative influence of the mutations on the photoreceptors (indicated by the saturated a-wave amplitude, right graph) was not substantially different from their effect on the b-wave response (dominated by the bipolars, left graph) at the same intensity of 10 cd·s/m2. To investigate the molecular mechanism that underlies the unique role of E2f1, we assessed the expression of known E2f targets as well as other genes that regulate the cell cycle and apoptosis.
T7588	15939-15941	TO	denotes	To
T7589	15942-15953	VB	denotes	investigate
T7590	16021-16029	VBD	denotes	assessed
T7591	15954-15957	DT	denotes	the
T7592	15968-15977	NN	denotes	mechanism
T7593	15958-15967	JJ	denotes	molecular
T7594	15978-15982	WDT	denotes	that
T7595	15983-15992	VBZ	denotes	underlies
T7596	15993-15996	DT	denotes	the
T13935	23513-23519	NN	denotes	Figure
T13936	23522-23523	-RRB-	denotes	)
T13937	23523-23524	.	denotes	.
T13938	23524-23683	sentence	denotes	We quantified Calb2+ cell bodies in the Rb KO INL (corresponding to amacrine cell staining only) and observed a reduction from P8 onwards (Figures 3C and S6).
T13939	23525-23527	PRP	denotes	We
T13940	23528-23538	VBD	denotes	quantified
T13941	23539-23544	NN	denotes	Calb2
T13942	23551-23557	NNS	denotes	bodies
T13943	23544-23545	SYM	denotes	+
T13944	23546-23550	NN	denotes	cell
T13945	23558-23560	IN	denotes	in
T13946	23561-23564	DT	denotes	the
T13947	23571-23574	NN	denotes	INL
T13948	23565-23567	NN	denotes	Rb
T13949	23568-23570	NN	denotes	KO
T13950	23575-23576	-LRB-	denotes	(
T13951	23576-23589	VBG	denotes	corresponding
T13952	23590-23592	IN	denotes	to
T13953	23593-23601	JJ	denotes	amacrine
T13954	23602-23606	NN	denotes	cell
T13955	23607-23615	NN	denotes	staining
T13956	23616-23620	RB	denotes	only
T13957	23620-23621	-RRB-	denotes	)
T13958	23622-23625	CC	denotes	and
T13959	23626-23634	VBD	denotes	observed
T13960	23635-23636	DT	denotes	a
T13961	23637-23646	NN	denotes	reduction
T13962	23647-23651	IN	denotes	from
T13963	23652-23654	NN	denotes	P8
T13964	23655-23662	RB	denotes	onwards
T13965	23663-23664	-LRB-	denotes	(
T13966	23672-23674	NN	denotes	3C
T13967	23664-23671	NNS	denotes	Figures
T13968	23675-23678	CC	denotes	and
T13969	23679-23681	NN	denotes	S6
T13970	23681-23682	-RRB-	denotes	)
T13971	23682-23683	.	denotes	.
T13972	23683-23684	sentence	denotes
T13973	24488-24489	sentence	denotes	O
T13974	24488-24489	NN	denotes	O
T13982	24496-24497	NN	denotes	h
T13983	24497-24499	JJ	denotes	re
T13984	24499-24500	JJ	denotes	e
T13985	24500-24504	sentence	denotes	Cal
T13986	24501-24503	NN	denotes	Ca
T13987	24503-24504	RB	denotes	l
T13988	24504-24509	sentence	denotes	b2+ t
T13989	24504-24506	NN	denotes	b2
T13990	24506-24507	SYM	denotes	+
T13991	24508-24509	DT	denotes	t
T13992	24509-24514	sentence	denotes	racks
T13997	24512-24513	NNP	denotes	k
T13998	24514-24518	sentence	denotes	in
T13999	24515-24517	IN	denotes	in
T14000	24518-24627	sentence	denotes	the IPL, the two outer tracks are from SACs, named after their extensive dendritic-tree-like morphology [37].
T14001	24548-24551	VBP	denotes	are
T14002	24518-24521	DT	denotes	the
T14003	24522-24525	NN	denotes	IPL
T14004	24525-24527	,	denotes	,
T14005	24527-24530	DT	denotes	the
T14006	24541-24547	NNS	denotes	tracks
T14007	24531-24534	CD	denotes	two
T14008	24535-24540	JJ	denotes	outer
T14009	24552-24556	IN	denotes	from
T14010	24557-24561	NNS	denotes	SACs
T14011	24561-24563	,	denotes	,
T14012	24563-24568	VBN	denotes	named
T14013	24569-24574	IN	denotes	after
T14014	24575-24580	PRP$	denotes	their
T14015	24611-24621	NN	denotes	morphology
T14016	24581-24590	JJ	denotes	extensive
T14017	24591-24600	JJ	denotes	dendritic
T14018	24601-24605	NN	denotes	tree
T14019	24600-24601	HYPH	denotes	-
T14020	24606-24610	JJ	denotes	like
T14021	24605-24606	HYPH	denotes	-
T14022	24622-24623	-LRB-	denotes	[
T14023	24623-24625	CD	denotes	37
T14024	24625-24626	-RRB-	denotes	]
T14025	24626-24627	.	denotes	.
T14026	24627-24833	sentence	denotes	SACs are cholinergic, represent ~5.2% of amacrine neurons [38], and are critical for both direction selectivity [34,35] and spontaneous rhythmic activity that occurs during normal retinal development [36].
T14027	24628-24632	NNS	denotes	SACs
T14028	24633-24636	VBP	denotes	are
T14030	24648-24650	,	denotes	,
T14031	24650-24659	VBP	denotes	represent
T14032	24660-24661	SYM	denotes	~
T4015	3953-3955	,	denotes	,
T4016	3962-3964	IN	denotes	in
T4017	3965-3968	DT	denotes	the
T4018	3983-3988	NN	denotes	layer
T4019	3969-3974	JJ	denotes	inner
T4020	3975-3982	JJ	denotes	nuclear
T4021	3989-3990	-LRB-	denotes	(
T4022	3990-3993	NN	denotes	INL
T4023	3993-3994	-RRB-	denotes	)
T4024	3994-3995	:	denotes	;
T4025	3996-3999	CC	denotes	and
T4026	4000-4008	NN	denotes	ganglion
T4027	4038-4042	VBP	denotes	form
T4028	4009-4012	CC	denotes	and
T4029	4013-4022	VBN	denotes	displaced
T4030	4023-4031	JJ	denotes	amacrine
T4031	4032-4037	NNS	denotes	cells
T4032	4043-4046	DT	denotes	the
T4033	4061-4066	NN	denotes	layer
T4034	4047-4055	NN	denotes	ganglion
T4035	4056-4060	NN	denotes	cell
T4036	4067-4068	-LRB-	denotes	(
T4037	4068-4071	NN	denotes	GCL
T4038	4071-4072	-RRB-	denotes	)
T4039	4073-4074	-LRB-	denotes	(
T4040	4081-4083	NN	denotes	1A
T4041	4074-4080	NN	denotes	Figure
T4042	4083-4084	-RRB-	denotes	)
T4043	4084-4085	.	denotes	.
T4044	4085-4226	sentence	denotes	The outer plexiform layer (OPL) and inner plexiform layer (IPL) house synaptic connections separating the ONL/INL and INL/GCL, respectively.
T4045	4086-4089	DT	denotes	The
T4046	4106-4111	NN	denotes	layer
T4047	4090-4095	JJ	denotes	outer
T4048	4096-4105	NN	denotes	plexiform
T4049	4150-4155	VBP	denotes	house
T4050	4112-4113	-LRB-	denotes	(
T4051	4113-4116	NN	denotes	OPL
T4052	4116-4117	-RRB-	denotes	)
T4053	4118-4121	CC	denotes	and
T4054	4122-4127	JJ	denotes	inner
T4055	4138-4143	NN	denotes	layer
T4056	4128-4137	NN	denotes	plexiform
T4075	5895-5899	sentence	denotes	The
T4076	5895-5896	NNS	denotes	T
T4077	5896-5898	DT	denotes	he
T4078	5899-5914	sentence	denotes	retinoblastoma
T4079	5899-5901	EX	denotes	re
T4080	5901-5903	VBN	denotes	ti
T4081	5903-5904	CC	denotes	n
T4082	5904-5905	NNS	denotes	o
T4083	5908-5909	NNS	denotes	s
T4084	5905-5908	JJ	denotes	bla
T4085	5909-5910	DT	denotes	t
T4086	5910-5911	NN	denotes	o
T4087	5911-5913	JJ	denotes	ma
T4088	5914-5915	sentence	denotes	p
T4089	5914-5915	NN	denotes	p
T4090	5915-5922	sentence	denotes	rotein
T4091	5915-5916	VB	denotes	r
T4092	5916-5918	NN	denotes	ot
T4093	5918-5921	VBG	denotes	ein
T4094	5922-5923	sentence	denotes	(
T4095	5922-5923	-LRB-	denotes	(
T4096	5923-5924	sentence	denotes	R
T4097	5923-5924	JJ	denotes	R
T4098	5924-5926	sentence	denotes	b)
T4099	5924-5925	NNS	denotes	b
T4100	5925-5926	-RRB-	denotes	)
T4101	5926-5996	sentence	denotes	is critical for cell cycle exit during retinal transition cell birth.
T4102	5927-5929	NN	denotes	is
T4103	5930-5938	JJ	denotes	critical
T4104	5939-5942	IN	denotes	for
T4105	5943-5947	NN	denotes	cell
T4106	5948-5953	NN	denotes	cycle
T4107	5954-5958	NN	denotes	exit
T4108	5959-5965	IN	denotes	during
T4109	5966-5973	JJ	denotes	retinal
T4110	5985-5989	NN	denotes	cell
T4111	5974-5984	NN	denotes	transition
T4112	5990-5995	NN	denotes	birth
T4113	5995-5996	.	denotes	.
T4114	5996-6126	sentence	denotes	Rb knockout (KO) RTCs continue to proliferate inappropriately and some (rod, ganglion, and bipolar cells) die by apoptosis [2,3].
T4115	5997-5999	NN	denotes	Rb
T4116	6000-6008	NN	denotes	knockout
T4117	6014-6018	NNS	denotes	RTCs
T4118	6009-6010	-LRB-	denotes	(
T4119	6010-6012	NN	denotes	KO
T4120	6012-6013	-RRB-	denotes	)
T4121	6019-6027	VBP	denotes	continue
T4122	6028-6030	TO	denotes	to
T4123	6031-6042	VB	denotes	proliferate
T4124	6043-6058	RB	denotes	inappropriately
T4125	6059-6062	CC	denotes	and
T4126	6063-6067	DT	denotes	some
T4127	6103-6106	VBP	denotes	die
T4128	6068-6069	-LRB-	denotes	(
T4129	6069-6072	NN	denotes	rod
T4130	6096-6101	NNS	denotes	cells
T4131	6072-6074	,	denotes	,
T4132	6074-6082	NN	denotes	ganglion
T4133	6082-6084	,	denotes	,
T4134	6084-6087	CC	denotes	and
T4135	6088-6095	JJ	denotes	bipolar
T4136	6101-6102	-RRB-	denotes	)
T4137	6107-6109	IN	denotes	by
T4138	6110-6119	NN	denotes	apoptosis
T4139	6120-6121	-LRB-	denotes	[
T4140	6123-6124	CD	denotes	3
T4141	6121-6122	CD	denotes	2
T4142	6122-6123	,	denotes	,
T4144	6125-6126	.	denotes	.
T4582	8250-8253	CC	denotes	and
R21	T641	T640	aux	has,known
R9	T626	T624	punct	-,Mediated
R10	T628	T627	amod	Neuronal,Differentiation
R11	T629	T627	prep	through,Differentiation
R12	T630	T631	compound	Cell,Cycle
R13	T631	T633	npadvmod	Cycle,Independent
R14	T632	T631	punct	-,Cycle
R15	T633	T635	amod	Independent,Regulation
R16	T634	T633	punct	–,Independent
R17	T635	T629	pobj	Regulation,through
R18	T636	T635	prep	of,Regulation
R19	T637	T636	pobj	E2f3a,of
R20	T639	T640	nsubjpass	It,known
R22	T642	T640	advmod	long,known
R23	T643	T640	auxpass	been,known
R24	T644	T645	mark	that,perturbs
R25	T645	T640	ccomp	perturbs,known
R26	T646	T645	nsubj	loss,perturbs
R27	T647	T646	prep	of,loss
R28	T648	T649	det	the,protein
R29	T649	T647	pobj	protein,of
R30	T650	T649	compound	retinoblastoma,protein
R31	T651	T649	punct	(,protein
R32	T652	T649	appos	Rb,protein
R33	T653	T645	punct	),perturbs
R34	T654	T655	amod	neural,differentiation
R35	T655	T645	dobj	differentiation,perturbs
R36	T656	T640	punct	", ",known
R37	T657	T640	cc	but,known
R38	T658	T659	det	the,mechanism
R39	T659	T661	nsubjpass	mechanism,solved
R40	T660	T659	amod	underlying,mechanism
R41	T661	T640	conj	solved,known
R42	T662	T661	aux	has,solved
R43	T663	T661	neg	never,solved
R44	T664	T661	auxpass	been,solved
R45	T665	T661	punct	.,solved
R46	T667	T668	compound	Rb,absence
R47	T668	T669	nsubj	absence,impairs
R48	T669	T670	ccomp	impairs,be
R49	T671	T672	compound	cell,cycle
R50	T672	T673	compound	cycle,exit
R51	T673	T669	dobj	exit,impairs
R52	T674	T669	cc	and,impairs
R53	T675	T669	conj	triggers,impairs
R54	T676	T675	dobj	death,triggers
R55	T677	T676	prep	of,death
R56	T678	T679	det	some,neurons
R57	T679	T677	pobj	neurons,of
R58	T680	T670	punct	", ",be
R59	T681	T670	advmod	so,be
R60	T682	T683	compound	differentiation,defects
R61	T683	T670	nsubj	defects,be
R62	T684	T670	aux	may,be
R63	T685	T670	advmod	well,be
R64	T686	T670	acomp	indirect,be
R65	T687	T670	punct	.,be
R66	T689	T690	advmod	Indeed,show
R67	T691	T690	punct	", ",show
R68	T692	T690	nsubj	we,show
R69	T693	T694	mark	that,rescued
R70	T694	T690	ccomp	rescued,show
R71	T695	T694	nsubjpass	abnormalities,rescued
R72	T696	T695	prep	in,abnormalities
R73	T697	T698	preconj	both,differentiation
R74	T698	T699	npadvmod	differentiation,evoked
R75	T699	T703	amod	evoked,responses
R76	T700	T698	cc	and,differentiation
R77	T701	T698	conj	light,differentiation
R78	T702	T699	punct	-,evoked
R79	T703	T696	pobj	responses,in
R80	T704	T703	amod	electrophysiological,responses
R81	T705	T695	prep	in,abnormalities
R82	T706	T707	npadvmod	Rb,deficient
R83	T707	T709	amod	deficient,cells
R84	T708	T707	punct	-,deficient
R85	T709	T705	pobj	cells,in
R86	T710	T709	amod	retinal,cells
R87	T711	T694	auxpass	are,rescued
R88	T712	T713	advmod	when,blocked
R89	T713	T694	advcl	blocked,rescued
R90	T714	T715	amod	ectopic,division
R91	T715	T713	nsubjpass	division,blocked
R92	T716	T715	cc	and,division
R93	T717	T715	conj	apoptosis,division
R94	T718	T713	auxpass	are,blocked
R95	T719	T713	advmod	specifically,blocked
R96	T720	T713	prep	by,blocked
R97	T721	T720	pcomp	deleting,by
R98	T722	T723	compound	E2f,factor
R99	T723	T721	dobj	factor,deleting
R100	T724	T723	compound	transcription,factor
R101	T725	T723	punct	(,factor
R102	T726	T723	appos	E2f,factor
R103	T727	T723	punct	),factor
R104	T728	T723	nummod	1,factor
R105	T729	T690	punct	.,show
R106	T731	T732	advmod	However,exposed
R107	T733	T732	punct	", ",exposed
R108	T734	T735	amod	comprehensive,analysis
R109	T735	T732	nsubj	analysis,exposed
R110	T736	T737	compound	cell,type
R111	T737	T735	compound	type,analysis
R112	T738	T737	punct	-,type
R113	T739	T735	prep	of,analysis
R114	T740	T741	det	the,retina
R115	T741	T739	pobj	retina,of
R116	T742	T741	amod	rescued,retina
R117	T743	T744	amod	double,null
R118	T744	T741	amod	null,retina
R119	T745	T744	punct	-,null
R120	T746	T747	compound	cell,cycle
R121	T747	T749	npadvmod	cycle,independent
R122	T748	T747	punct	-,cycle
R123	T749	T751	amod	independent,defects
R124	T750	T749	punct	–,independent
R125	T751	T732	dobj	defects,exposed
R126	T752	T751	compound	differentiation,defects
R127	T753	T754	advmod	specifically,in
R128	T754	T732	prep	in,exposed
R129	T755	T756	nmod	starburst,cells
R130	T756	T754	pobj	cells,in
R131	T757	T756	amod	amacrine,cells
R132	T758	T756	punct	(,cells
R133	T759	T756	appos	SACs,cells
R134	T760	T756	punct	),cells
R135	T761	T756	punct	", ",cells
R136	T762	T763	amod	cholinergic,interneurons
R137	T763	T756	appos	interneurons,cells
R138	T764	T763	amod	critical,interneurons
R139	T765	T764	prep	in,critical
R140	T766	T767	compound	direction,selectivity
R141	T767	T765	pobj	selectivity,in
R142	T768	T767	cc	and,selectivity
R143	T769	T770	advmod	developmentally,important
R144	T770	T771	amod	important,bursts
R145	T771	T767	conj	bursts,selectivity
R146	T772	T771	amod	rhythmic,bursts
R147	T773	T732	punct	.,exposed
R148	T775	T776	advmod	Typically,thought
R149	T777	T776	punct	", ",thought
R150	T778	T776	nsubjpass	Rb,thought
R151	T779	T776	auxpass	is,thought
R152	T780	T781	aux	to,block
R153	T781	T776	xcomp	block,thought
R154	T782	T781	dobj	division,block
R155	T783	T781	prep	by,block
R156	T784	T783	pcomp	repressing,by
R157	T785	T784	dobj	E2fs,repressing
R158	T786	T781	punct	", ",block
R159	T787	T781	cc	but,block
R160	T788	T789	aux	to,promote
R161	T789	T781	conj	promote,block
R162	T790	T789	dobj	differentiation,promote
R163	T791	T789	prep	by,promote
R164	T792	T791	pcomp	potentiating,by
R165	T793	T794	npadvmod	tissue,specific
R166	T794	T796	amod	specific,factors
R167	T795	T794	punct	-,specific
R168	T796	T792	dobj	factors,potentiating
R169	T797	T776	punct	.,thought
R170	T799	T800	advmod	Remarkably,promotes
R171	T801	T800	punct	", ",promotes
R172	T802	T800	advmod	however,promotes
R173	T803	T800	punct	", ",promotes
R174	T804	T800	nsubj	Rb,promotes
R175	T805	T806	compound	SAC,differentiation
R176	T806	T800	dobj	differentiation,promotes
R177	T807	T800	prep	by,promotes
R178	T808	T807	pcomp	inhibiting,by
R179	T809	T810	compound	E2f3,activity
R180	T810	T808	dobj	activity,inhibiting
R181	T811	T800	punct	.,promotes
R182	T813	T814	nummod	Two,isoforms
R183	T814	T816	nsubj	isoforms,exist
R184	T815	T814	compound	E2f3,isoforms
R185	T817	T816	punct	", ",exist
R186	T818	T816	cc	and,exist
R187	T819	T820	nsubj	we,find
R188	T820	T816	conj	find,exist
R189	T821	T820	dobj	both,find
R190	T822	T820	prep	in,find
R191	T823	T824	det	the,retina
R192	T824	T822	pobj	retina,in
R193	T825	T824	amod	developing,retina
R194	T826	T820	punct	", ",find
R195	T827	T828	mark	although,show
R196	T828	T820	advcl	show,find
R197	T829	T828	advmod	intriguingly,show
R198	T830	T828	nsubj	they,show
R199	T831	T832	amod	distinct,distribution
R200	T832	T828	dobj	distribution,show
R201	T833	T832	amod	subcellular,distribution
R202	T834	T820	punct	.,find
R203	T836	T837	nsubjpass	E2f3b,thought
R204	T838	T837	auxpass	is,thought
R205	T839	T840	aux	to,mediate
R206	T840	T837	xcomp	mediate,thought
R207	T841	T842	compound	Rb,function
R208	T842	T840	dobj	function,mediate
R209	T843	T840	prep	in,mediate
R210	T844	T845	amod	quiescent,cells
R211	T845	T843	pobj	cells,in
R212	T846	T837	punct	.,thought
R213	T848	T849	advmod	However,show
R214	T850	T849	punct	", ",show
R215	T851	T849	prep	in,show
R216	T852	T853	dep	what,is
R217	T853	T851	pcomp	is,in
R218	T854	T853	prep	to,is
R219	T855	T856	poss	our,knowledge
R220	T856	T854	pobj	knowledge,to
R221	T857	T858	det	the,work
R222	T858	T853	attr	work,is
R223	T859	T858	amod	first,work
R224	T860	T861	aux	to,dissect
R225	T861	T858	advcl	dissect,work
R226	T862	T863	compound	E2f,function
R227	T863	T861	dobj	function,dissect
R228	T864	T863	compound	isoform,function
R229	T865	T866	advmod	in,vivo
R230	T866	T861	advmod	vivo,dissect
R231	T867	T849	nsubj	we,show
R232	T868	T869	mark	that,promotes
R233	T869	T849	ccomp	promotes,show
R234	T870	T869	nsubj	Rb,promotes
R235	T871	T872	compound	SAC,differentiation
R236	T872	T869	dobj	differentiation,promotes
R237	T873	T869	prep	through,promotes
R238	T874	T873	pobj	E2f3a,through
R239	T875	T849	punct	.,show
R240	T877	T878	det	These,data
R241	T878	T879	nsubj	data,reveal
R242	T880	T881	det	a,mechanism
R243	T881	T879	dobj	mechanism,reveal
R244	T882	T883	prep	through,regulates
R245	T883	T881	relcl	regulates,mechanism
R246	T884	T882	pobj	which,through
R247	T885	T883	nsubj	Rb,regulates
R248	T886	T887	amod	neural,differentiation
R249	T887	T883	dobj	differentiation,regulates
R250	T888	T883	advmod	directly,regulates
R251	T889	T879	punct	", ",reveal
R252	T890	T879	cc	and,reveal
R253	T891	T879	punct	", ",reveal
R254	T892	T893	advmod	unexpectedly,involves
R255	T893	T879	conj	involves,reveal
R256	T894	T893	punct	", ",involves
R257	T895	T893	nsubj	it,involves
R258	T896	T893	dobj	inhibition,involves
R259	T897	T896	prep	of,inhibition
R260	T898	T897	pobj	E2f3a,of
R261	T899	T896	punct	", ",inhibition
R262	T900	T896	neg	not,inhibition
R263	T901	T896	appos	potentiation,inhibition
R264	T902	T901	prep	of,potentiation
R265	T903	T904	npadvmod	tissue,specific
R266	T904	T906	amod	specific,factors
R267	T905	T904	punct	-,specific
R268	T906	T902	pobj	factors,of
R269	T907	T893	punct	.,involves
R270	T623	T624	npadvmod	Rb,Mediated
R271	T624	T627	amod	Mediated,Differentiation
R285	T3864	T3865	det	The,simplicity
R289	T3865	T3866	nsubj	simplicity,makes
R290	T3867	T3865	prep	of,simplicity
R291	T3868	T3869	det	the,retina
R292	T3869	T3867	pobj	retina,of
R293	T3870	T3871	nsubj	it,tissue
R294	T3871	T3866	ccomp	tissue,makes
R295	T3872	T3871	det	an,tissue
R296	T3873	T3871	amod	ideal,tissue
R297	T3874	T3875	aux	to,study
R298	T3875	T3871	advcl	study,tissue
R299	T3876	T3875	dobj	neurogenesis,study
R300	T3877	T3866	punct	.,makes
R301	T3879	T3880	poss	Its,development
R302	T3880	T3881	nsubj	development,proceeds
R303	T3882	T3881	prep	through,proceeds
R304	T3883	T3884	nummod	three,steps
R305	T3884	T3882	pobj	steps,through
R306	T3885	T3884	amod	overlapping,steps
R307	T3886	T3881	advcl	starting,proceeds
R308	T3887	T3886	prep	with,starting
R309	T3888	T3889	amod	retinal,cell
R310	T3889	T3891	nmod	cell,proliferation
R311	T3890	T3889	nmod	progenitor,cell
R312	T3891	T3887	pobj	proliferation,with
R313	T3892	T3889	punct	(,cell
R314	T3893	T3889	appos	RPC,cell
R315	T3894	T3891	punct	),proliferation
R316	T3895	T3891	punct	", ",proliferation
R317	T3896	T3891	acl	followed,proliferation
R318	T3897	T3896	agent	by,followed
R319	T3898	T3897	pobj	birth,by
R320	T3899	T3898	prep	of,birth
R321	T3900	T3901	amod	post-mitotic,cells
R322	T3909	T3908	prep	to,referred
R323	T3910	T3908	prep	as,referred
R324	T3911	T3910	pobj	precursors,as
R325	T3912	T3886	punct	),starting
R326	T3913	T3886	punct	", ",starting
R327	T3901	T3899	pobj	cells,of
R328	T3914	T3886	cc	and,starting
R329	T3915	T3886	conj	ending,starting
R330	T3916	T3915	prep	with,ending
R331	T3917	T3918	amod	terminal,differentiation
R332	T3902	T3901	amod	retinal,cells
R333	T3918	T3916	pobj	differentiation,with
R334	T3919	T3918	prep	of,differentiation
R335	T3920	T3921	nummod	seven,types
R336	T3903	T3901	compound	transition,cells
R337	T3921	T3919	pobj	types,of
R338	T3922	T3921	amod	major,types
R339	T3923	T3921	compound	cell,types
R340	T3904	T3901	punct	(,cells
R341	T3924	T3925	punct	(,1A
R342	T3925	T3881	parataxis	1A,proceeds
R343	T3926	T3925	compound	Figure,1A
R344	T3905	T3901	appos	RTCs,cells
R345	T3927	T3925	punct	),1A
R346	T3928	T3929	punct	[,1
R347	T3906	T3901	punct	", ",cells
R348	T3929	T3881	parataxis	1,proceeds
R349	T3930	T3929	punct	],1
R350	T3931	T3881	punct	.,proceeds
R351	T3907	T3908	advmod	also,referred
R352	T3933	T3934	nsubj	RPCs,are
R353	T3908	T3901	acl	referred,cells
R354	T3935	T3934	acomp	multipotent,are
R355	T3936	T3934	cc	and,are
R356	T4015	T4006	punct	", ",reside
R357	T3937	T3934	conj	exit,are
R358	T3938	T3939	det	the,cycle
R359	T3939	T3937	dobj	cycle,exit
R360	T4016	T4006	prep	in,reside
R361	T3940	T3939	compound	cell,cycle
R362	T3941	T3942	aux	to,generate
R363	T3942	T3937	advcl	generate,exit
R364	T4017	T4018	det	the,layer
R365	T3943	T3944	amod	different,RTCs
R366	T4018	T4016	pobj	layer,in
R367	T3944	T3942	dobj	RTCs,generate
R368	T3945	T3942	prep	at,generate
R369	T4019	T4018	amod	inner,layer
R370	T3946	T3947	amod	specific,periods
R371	T3947	T3945	pobj	periods,at
R372	T3948	T3947	compound	time,periods
R373	T4020	T4018	amod	nuclear,layer
R374	T3949	T3947	prep	in,periods
R375	T3950	T3949	pobj	development,in
R376	T3951	T3952	punct	[,1
R377	T3952	T3942	parataxis	1,generate
R378	T3953	T3952	punct	],1
R379	T3954	T3934	punct	.,are
R380	T4021	T4018	punct	(,layer
R381	T3956	T3957	det	This,process
R382	T3957	T3958	nsubj	process,requires
R383	T4022	T4018	appos	INL,layer
R384	T3959	T3957	prep	of,process
R385	T3960	T3961	nmod	RTC,birth
R386	T3961	T3959	pobj	birth,of
R387	T4023	T4006	punct	),reside
R388	T3962	T3961	punct	“,birth
R389	T3963	T3958	punct	”,requires
R390	T3964	T3958	dobj	coupling,requires
R391	T4024	T4006	punct	;,reside
R392	T3965	T3964	prep	of,coupling
R393	T3966	T3965	pobj	differentiation,of
R394	T3967	T3966	cc	and,differentiation
R395	T4025	T4006	cc	and,reside
R396	T3968	T3969	compound	cell,cycle
R397	T3969	T3970	compound	cycle,exit
R398	T3970	T3966	conj	exit,differentiation
R399	T4026	T4027	nsubj	ganglion,form
R400	T3971	T3958	punct	.,requires
R402	T3973	T3974	mark	Once,born
R403	T4028	T4026	cc	and,ganglion
R404	T3974	T3975	advcl	born,migrate
R405	T3976	T3975	punct	", ",migrate
R406	T4029	T4030	amod	displaced,amacrine
R407	T3977	T3978	amod	post-mitotic,RTCs
R408	T3978	T3975	nsubj	RTCs,migrate
R409	T3979	T3975	cc	and,migrate
R410	T4030	T4031	nmod	amacrine,cells
R411	T3980	T3975	conj	form,migrate
R412	T3981	T3982	amod	different,layers
R413	T3982	T3980	dobj	layers,form
R415	T3983	T3982	amod	retinal,layers
R416	T3984	T3975	punct	.,migrate
R417	T3986	T3987	nsubj	Rods,make
R419	T3988	T3986	cc	and,Rods
R421	T3989	T3986	conj	cones,Rods
R422	T3990	T3987	prt	up,make
R423	T3991	T3992	det	the,layer
R424	T3992	T3987	dobj	layer,make
R426	T3993	T3992	amod	outer,layer
R427	T3994	T3992	amod	nuclear,layer
R428	T3995	T3992	punct	(,layer
R429	T3996	T3992	appos	ONL,layer
R430	T3997	T3987	punct	),make
R431	T3998	T3987	punct	;,make
R432	T3999	T4000	amod	horizontal,cells
R434	T4000	T4006	nsubj	cells,reside
R435	T4001	T3999	punct	", ",horizontal
R436	T4002	T3999	conj	bipolar,horizontal
R438	T4003	T4002	punct	", ",bipolar
R439	T4004	T4002	cc	and,bipolar
R440	T4005	T4002	conj	amacrine,bipolar
R442	T4006	T3987	conj	reside,make
R443	T4007	T4000	punct	", ",cells
R444	T4008	T4009	advmod	as,as
R446	T4009	T4000	cc	as,cells
R447	T4010	T4009	advmod	well,as
R448	T4011	T4012	compound	Müller,glia
R450	T4012	T4013	compound	glia,bodies
R451	T4013	T4000	conj	bodies,cells
R452	T4014	T4013	compound	cell,bodies
R481	T4069	T4064	conj	GCL,INL
R482	T4070	T4069	punct	/,GCL
R485	T4071	T4049	punct	", ",house
R488	T4072	T4049	advmod	respectively,house
R492	T4073	T4049	punct	.,house
R503	T4122	T4123	aux	to,proliferate
R504	T4123	T4121	xcomp	proliferate,continue
R505	T4124	T4123	advmod	inappropriately,proliferate
R506	T4162	T4156	parataxis	1B,factors
R507	T4125	T4121	cc	and,continue
R508	T4126	T4127	nsubj	some,die
R509	T4163	T4162	compound	Figure,1B
R510	T4127	T4121	conj	die,continue
R511	T4128	T4126	punct	(,some
R512	T4129	T4130	nmod	rod,cells
R513	T4164	T4162	punct	),1B
R514	T4130	T4126	appos	cells,some
R515	T4131	T4129	punct	", ",rod
R516	T4132	T4129	conj	ganglion,rod
R517	T4165	T4156	punct	", ",factors
R518	T4133	T4132	punct	", ",ganglion
R519	T4134	T4132	cc	and,ganglion
R520	T4135	T4132	conj	bipolar,ganglion
R521	T4166	T4167	advmod	first,defined
R522	T4136	T4127	punct	),die
R523	T4137	T4127	prep	by,die
R524	T4138	T4137	pobj	apoptosis,by
R525	T4139	T4140	punct	[,3
R526	T4167	T4156	acl	defined,factors
R527	T4140	T4127	parataxis	3,die
R528	T4141	T4140	nummod	2,3
R529	T4142	T4140	punct	",",3
R530	T4168	T4167	prep	as,defined
R531	T4143	T4140	punct	],3
R532	T4144	T4127	punct	.,die
R533	T4146	T4147	nsubj	Rb,controls
R534	T4169	T4170	compound	transcription,factors
R535	T4148	T4149	det	the,cycle
R536	T4149	T4147	dobj	cycle,controls
R537	T4150	T4149	compound	cell,cycle
R538	T4151	T4147	prep	by,controls
R539	T4170	T4168	pobj	factors,as
R540	T4152	T4151	pcomp	binding,by
R541	T4153	T4152	cc	and,binding
R542	T4154	T4152	conj	inhibiting,binding
R543	T4171	T4172	dep	that,bind
R544	T4155	T4156	compound	E2f,factors
R545	T4156	T4154	dobj	factors,inhibiting
R546	T4157	T4156	compound	transcription,factors
R547	T4172	T4170	relcl	bind,factors
R548	T4158	T4156	punct	(,factors
R549	T4173	T4174	amod	adenoviral,elements
R550	T4174	T4172	dobj	elements,bind
R551	T4265	T4263	pobj	extents,to
R552	T4175	T4176	npadvmod	E2,regulatory
R553	T4266	T4256	prep	in,rescued
R554	T4267	T4268	amod	different,tissues
R555	T4268	T4266	pobj	tissues,in
R556	T4176	T4174	amod	regulatory,elements
R557	T4269	T4256	prep	by,rescued
R558	T4270	T4269	pcomp	knocking,by
R559	T4177	T4167	cc	and,defined
R560	T4271	T4270	prt	out,knocking
R561	T4272	T4270	dobj	E2f1,knocking
R562	T4273	T4272	punct	", ",E2f1
R563	T4178	T4179	advmod	subsequently,shown
R564	T4274	T4272	conj	E2f2,E2f1
R565	T4179	T4167	conj	shown,defined
R566	T4275	T4274	punct	", ",E2f2
R567	T4180	T4181	aux	to,be
R568	T4276	T4274	cc	or,E2f2
R569	T4277	T4274	conj	E2f3,E2f2
R570	T4181	T4179	xcomp	be,shown
R571	T4278	T4279	punct	[,6
R572	T4279	T4270	parataxis	6,knocking
R573	T4182	T4183	amod	critical,regulators
R574	T4280	T4281	punct	–,9
R575	T4281	T4279	prep	9,6
R576	T4282	T4279	punct	],6
R577	T4283	T4256	punct	", ",rescued
R578	T4183	T4181	attr	regulators,be
R579	T4284	T4256	cc	but,rescued
R580	T4285	T4286	det	which,member
R581	T4286	T4287	dep	member,drive
R582	T4184	T4185	compound	cell,cycle
R583	T4287	T4291	csubj	drive,is
R584	T4288	T4286	punct	(,member
R585	T4289	T4286	nmod	s,member
R586	T4290	T4286	punct	),member
R587	T4291	T4256	conj	is,rescued
R588	T4292	T4287	dobj	division,drive
R589	T4185	T4183	compound	cycle,regulators
R590	T4293	T4287	prep	in,drive
R591	T4294	T4295	compound	Rb,KO
R592	T4186	T4187	punct	[,5
R593	T4295	T4296	compound	KO,RTCs
R594	T4296	T4293	pobj	RTCs,in
R595	T4297	T4291	acomp	unknown,is
R596	T4298	T4291	punct	.,is
R597	T4187	T4181	parataxis	5,be
R598	T4300	T4301	amod	Other,members
R599	T4188	T4187	nummod	4,5
R600	T4301	T4302	nsubjpass	members,known
R601	T4303	T4301	prep	of,members
R602	T4189	T4187	punct	",",5
R603	T4304	T4305	det	the,family
R604	T4305	T4303	pobj	family,of
R605	T4190	T4187	punct	],5
R606	T4306	T4301	punct	", ",members
R607	T4307	T4308	amod	such,as
R608	T4308	T4301	prep	as,members
R609	T4191	T4147	punct	.,controls
R610	T4309	T4308	pobj	E2f4,as
R611	T4310	T4309	cc	and,E2f4
R612	T4311	T4309	conj	E2f5,E2f4
R613	T4193	T4194	nsubj	E2fs,bind
R614	T4312	T4302	punct	", ",known
R615	T4313	T4302	auxpass	are,known
R616	T4314	T4302	prep	as,known
R617	T4315	T4316	punct	“,E2fs
R618	T4316	T4314	pobj	E2fs,as
R619	T4195	T4194	prep	to,bind
R620	T4317	T4316	amod	repressive,E2fs
R621	T4318	T4302	punct	”,known
R622	T4319	T4320	mark	because,are
R623	T4320	T4302	advcl	are,known
R624	T4196	T4195	pobj	DNA,to
R625	T4321	T4320	nsubj	they,are
R626	T4322	T4323	amod	weak,activators
R627	T4197	T4194	prep	as,bind
R628	T4323	T4320	attr	activators,are
R629	T4324	T4320	cc	and,are
R630	T4325	T4320	conj	appear,are
R631	T4198	T4197	pobj	heterodimers,as
R632	T4326	T4327	aux	to,involved
R633	T4327	T4325	xcomp	involved,appear
R634	T4328	T4327	auxpass	be,involved
R635	T4329	T4327	advmod	primarily,involved
R636	T4330	T4327	prep	in,involved
R637	T4199	T4198	prep	with,heterodimers
R638	T4331	T4332	compound	gene,silencing
R639	T4332	T4330	pobj	silencing,in
R640	T4333	T4327	prep	in,involved
R641	T4200	T4199	pobj	proteins,with
R642	T4334	T4335	amod	quiescent,cells
R643	T4335	T4333	pobj	cells,in
R644	T4201	T4200	prep	of,proteins
R645	T4336	T4334	cc	or,quiescent
R646	T4337	T4334	conj	differentiated,quiescent
R647	T4202	T4203	det	the,family
R648	T4338	T4302	punct	.,known
R649	T4340	T4341	csubj	Activating,promote
R650	T4203	T4201	pobj	family,of
R651	T4342	T4340	dobj	E2fs,Activating
R652	T4343	T4341	aux	may,promote
R653	T4204	T4203	amod	related,family
R654	T4344	T4341	advmod	also,promote
R655	T4345	T4341	dobj	apoptosis,promote
R656	T4205	T4203	compound	Tfdp,family
R657	T4346	T4341	prep	in,promote
R658	T4206	T4194	punct	.,bind
R659	T4347	T4348	det	the,retina
R660	T4348	T4346	pobj	retina,in
R661	T4208	T4209	nsubj	E2f1,are
R662	T4349	T4350	compound	Rb,KO
R663	T4350	T4348	compound	KO,retina
R664	T4351	T4352	punct	(,1B
R665	T4352	T4341	parataxis	1B,promote
R666	T4210	T4208	punct	", ",E2f1
R667	T4353	T4352	compound	Figure,1B
R668	T4354	T4352	punct	),1B
R669	T4355	T4341	punct	.,promote
R670	T4211	T4208	conj	E2f2,E2f1
R671	T4357	T4358	advmod	Originally,considered
R672	T4212	T4211	punct	", ",E2f2
R673	T4359	T4358	punct	", ",considered
R674	T4360	T4358	nsubjpass	E2f1,considered
R675	T4213	T4211	cc	and,E2f2
R676	T4361	T4358	auxpass	was,considered
R677	T4362	T4363	det	the,member
R678	T4363	T4358	oprd	member,considered
R679	T4214	T4211	conj	E2f3a,E2f2
R680	T4364	T4363	amod	primary,member
R681	T4365	T4363	amod	pro-apoptotic,member
R682	T4366	T4363	prep	of,member
R683	T4215	T4209	punct	“,are
R684	T4367	T4368	det	the,family
R685	T4368	T4366	pobj	family,of
R686	T4369	T4370	punct	[,10
R687	T4370	T4358	parataxis	10,considered
R688	T4216	T4217	compound	activating,E2fs
R689	T4217	T4209	attr	E2fs,are
R690	T4371	T4370	punct	],10
R691	T4372	T4358	punct	.,considered
R692	T4218	T4217	punct	”,E2fs
R693	T4374	T4375	advmod	However,reevaluated
R694	T4376	T4375	punct	", ",reevaluated
R695	T4219	T4220	dep	that,required
R696	T4377	T4378	det	this,view
R697	T4378	T4375	nsubjpass	view,reevaluated
R698	T4220	T4217	relcl	required,E2fs
R699	T4379	T4375	auxpass	was,reevaluated
R700	T4380	T4381	advmod	when,shown
R701	T4221	T4220	auxpass	are,required
R702	T4381	T4375	advcl	shown,reevaluated
R703	T4382	T4381	nsubjpass	it,shown
R704	T4383	T4381	auxpass	was,shown
R705	T4384	T4385	mark	that,rescues
R706	T4222	T4220	prep	for,required
R707	T4385	T4381	ccomp	rescues,shown
R708	T4386	T4387	preconj	either,E2f1
R709	T4387	T4388	nmod	E2f1,deletion
R710	T4223	T4224	compound	fibroblast,division
R711	T4388	T4385	nsubj	deletion,rescues
R712	T4389	T4387	cc	or,E2f1
R713	T4390	T4387	conj	E2f3,E2f1
R714	T4224	T4222	pobj	division,for
R715	T4391	T4385	dobj	apoptosis,rescues
R716	T4392	T4385	prep	in,rescues
R717	T4393	T4394	det	the,system
R718	T4225	T4209	punct	.,are
R719	T4394	T4392	pobj	system,in
R720	T4395	T4394	amod	developing,system
R721	T4396	T4394	amod	central,system
R722	T4227	T4228	nsubj	They,are
R723	T4397	T4394	amod	nervous,system
R724	T4398	T4394	punct	(,system
R725	T4399	T4394	appos	CNS,system
R726	T4400	T4394	punct	),system
R727	T4229	T4230	amod	strong,activators
R728	T4401	T4394	prep	of,system
R729	T4402	T4403	compound	Rb,KO
R730	T4403	T4404	compound	KO,embryos
R731	T4404	T4401	pobj	embryos,of
R732	T4230	T4228	attr	activators,are
R733	T4405	T4406	punct	[,11
R734	T4406	T4381	parataxis	11,shown
R735	T4407	T4406	nummod	6,11
R736	T4231	T4230	amod	transcriptional,activators
R737	T4408	T4406	punct	",",11
R738	T4409	T4406	punct	],11
R739	T4410	T4375	punct	.,reevaluated
R740	T4412	T4413	advmod	Subsequently,shown
R741	T4232	T4233	dep	that,drive
R742	T4414	T4413	punct	", ",shown
R743	T4415	T4416	compound	CNS,apoptosis
R744	T4416	T4413	nsubjpass	apoptosis,shown
R745	T4233	T4230	relcl	drive,activators
R746	T4417	T4413	auxpass	was,shown
R747	T4418	T4419	aux	to,be
R748	T4419	T4413	xcomp	be,shown
R749	T4234	T4233	aux	can,drive
R750	T4420	T4421	det	an,result
R751	T4421	T4419	attr	result,be
R752	T4235	T4236	compound	G0,fibroblasts
R753	T4422	T4421	amod	indirect,result
R754	T4423	T4421	prep	of,result
R755	T4424	T4425	amod	placental,defects
R756	T4236	T4233	dobj	fibroblasts,drive
R757	T4425	T4423	pobj	defects,of
R758	T4426	T4425	cc	and,defects
R759	T4427	T4428	amod	probable,hypoxia
R760	T4237	T4233	prep	into,drive
R761	T4428	T4425	conj	hypoxia,defects
R762	T4429	T4430	punct	[,12
R763	T4430	T4419	parataxis	12,be
R764	T4238	T4237	pobj	cycle,into
R765	T4431	T4432	punct	–,14
R766	T4432	T4430	prep	14,12
R767	T4433	T4430	punct	],12
R768	T4239	T4228	punct	", ",are
R769	T4240	T4228	cc	and,are
R770	T4434	T4413	punct	.,shown
R771	T4241	T4242	auxpass	are,inhibited
R772	T4436	T4437	advmod	Indeed,shown
R773	T4242	T4228	conj	inhibited,are
R774	T4438	T4437	punct	", ",shown
R775	T4439	T4440	npadvmod	E2f3,induced
R776	T4243	T4244	advmod	when,bound
R777	T4440	T4442	amod	induced,apoptosis
R778	T4441	T4440	punct	-,induced
R779	T4442	T4437	nsubjpass	apoptosis,shown
R780	T4244	T4242	advcl	bound,inhibited
R781	T4443	T4442	prep	in,apoptosis
R782	T4444	T4443	pobj	fibroblasts,in
R783	T4245	T4244	prep	to,bound
R784	T4445	T4437	aux	has,shown
R785	T4446	T4437	advmod	recently,shown
R786	T4447	T4437	auxpass	been,shown
R787	T4246	T4245	pobj	Rb,to
R788	T4448	T4449	aux	to,require
R789	T4449	T4437	xcomp	require,shown
R790	T4450	T4449	dobj	E2f1,require
R791	T4451	T4452	punct	[,15
R792	T4452	T4449	parataxis	15,require
R793	T4453	T4452	punct	],15
R794	T4247	T4248	punct	[,5
R795	T4454	T4437	punct	.,shown
R796	T4456	T4457	advmod	Thus,is
R797	T4248	T4244	parataxis	5,bound
R798	T4458	T4457	punct	", ",is
R799	T4249	T4248	nummod	4,5
R800	T4459	T4457	nsubj	it,is
R801	T4460	T4457	acomp	controversial,is
R802	T4461	T4462	mark	whether,required
R803	T4250	T4248	punct	",",5
R804	T4462	T4457	ccomp	required,is
R805	T4463	T4462	nsubjpass	E2f3,required
R806	T4464	T4462	auxpass	is,required
R807	T4251	T4248	punct	],5
R808	T4465	T4462	prep	for,required
R809	T4466	T4465	pobj	apoptosis,for
R810	T4252	T4228	punct	.,are
R811	T4467	T4466	prep	of,apoptosis
R812	T4468	T4469	det	any,type
R813	T4469	T4467	pobj	type,of
R814	T4254	T4255	amod	Ectopic,division
R815	T4470	T4471	compound	Rb,KO
R816	T4471	T4469	compound	KO,type
R817	T4472	T4469	compound	cell,type
R818	T4473	T4457	punct	.,is
R819	T4255	T4256	nsubjpass	division,rescued
R820	T4475	T4476	csubj	Determining,requires
R821	T4257	T4255	prep	in,division
R822	T4258	T4259	compound	Rb,KO
R823	T4259	T4260	compound	KO,embryos
R824	T4477	T4478	det	which,E2fs
R825	T4478	T4480	dep	E2fs,promote
R826	T4479	T4478	amod	activating,E2fs
R827	T4260	T4257	pobj	embryos,in
R828	T4480	T4475	ccomp	promote,Determining
R829	T4481	T4480	dobj	death,promote
R830	T4482	T4480	prep	in,promote
R831	T4261	T4256	aux	can,rescued
R832	T4483	T4484	amod	distinct,tissues
R833	T4484	T4482	pobj	tissues,in
R834	T4485	T4486	compound	Rb,KO
R835	T4262	T4256	auxpass	be,rescued
R836	T4486	T4484	compound	KO,tissues
R837	T4487	T4488	amod	conditional,models
R838	T4263	T4256	prep	to,rescued
R839	T4488	T4476	dobj	models,requires
R840	T4489	T4490	advmod	rather,than
R841	T4490	T4487	cc	than,conditional
R842	T4491	T4492	compound	germ,line
R843	T4492	T4487	conj	line,conditional
R844	T4493	T4488	prep	of,models
R845	T4264	T4265	amod	various,extents
R846	T4494	T4495	compound	Rb,deletion
R847	T4495	T4493	pobj	deletion,of
R848	T4496	T4497	aux	to,avoid
R849	T4582	T4580	cc	and,quiescent
R850	T4497	T4476	advcl	avoid,requires
R851	T4498	T4499	amod	secondary,effects
R852	T4499	T4497	dobj	effects,avoid
R853	T4500	T4499	amod	indirect,effects
R854	T4501	T4499	punct	(,effects
R855	T4583	T4580	conj	dividing,quiescent
R856	T4502	T4503	amod	such,as
R857	T4503	T4499	prep	as,effects
R858	T4504	T4503	pobj	hypoxia,as
R859	T4584	T4571	punct	", ",is
R860	T4505	T4476	punct	),requires
R861	T4506	T4476	punct	.,requires
R862	T4585	T4571	cc	and,is
R863	T4508	T4509	compound	E2f,diversity
R864	T4509	T4511	nsubjpass	diversity,expanded
R865	T4586	T4587	prep	in,associates
R866	T4510	T4509	compound	family,diversity
R867	T4512	T4511	auxpass	is,expanded
R868	T4587	T4571	conj	associates,is
R869	T4513	T4511	agent	by,expanded
R870	T4514	T4515	compound	E2f3,isoforms
R871	T4515	T4513	pobj	isoforms,by
R872	T4516	T4511	punct	.,expanded
R873	T4588	T4589	amod	quiescent,fibroblasts
R874	T4518	T4519	amod	Alternative,promoters
R875	T4589	T4586	pobj	fibroblasts,in
R876	T4519	T4520	nsubj	promoters,generate
R877	T4521	T4522	nummod	two,forms
R878	T4590	T4587	nsubj	it,associates
R879	T4522	T4520	dobj	forms,generate
R880	T4523	T4522	punct	(,forms
R881	T4524	T4522	appos	a,forms
R882	T4591	T4592	advmod	primarily,with
R883	T4592	T4587	prep	with,associates
R884	T4525	T4524	cc	and,a
R885	T4526	T4524	conj	b,a
R886	T4593	T4592	pobj	Rb,with
R887	T4527	T4522	punct	),forms
R888	T4528	T4529	dep	that,are
R889	T4594	T4587	punct	", ",associates
R890	T4529	T4522	relcl	are,forms
R891	T4530	T4529	acomp	identical,are
R892	T4531	T4529	prep	except,are
R893	T4595	T4587	advcl	suggesting,associates
R894	T4532	T4531	prep	for,except
R895	T4533	T4534	amod	distinct,exons
R896	T4534	T4532	pobj	exons,for
R897	T4535	T4534	amod	first,exons
R898	T4536	T4537	punct	[,16
R899	T4596	T4597	mark	that,mediates
R900	T4537	T4520	parataxis	16,generate
R901	T4538	T4537	punct	],16
R902	T4597	T4595	ccomp	mediates,suggesting
R903	T4539	T4520	punct	.,generate
R904	T4541	T4542	nsubj	E2f3a,is
R905	T4598	T4597	nsubj	it,mediates
R906	T4543	T4544	det	a,activator
R907	T4544	T4542	attr	activator,is
R908	T4599	T4597	dobj	repression,mediates
R909	T4545	T4544	amod	strong,activator
R910	T4546	T4542	punct	", ",is
R911	T4547	T4542	cc	and,is
R912	T4548	T4542	punct	", ",is
R913	T4600	T4601	punct	[,16
R914	T4549	T4550	prep	like,induced
R915	T4550	T4542	conj	induced,is
R916	T4601	T4587	parataxis	16,associates
R917	T4551	T4552	amod	other,E2fs
R918	T4602	T4603	punct	–,18
R919	T4552	T4549	pobj	E2fs,like
R920	T4553	T4552	amod	activating,E2fs
R921	T4554	T4550	punct	", ",induced
R922	T4603	T4601	prep	18,16
R923	T4555	T4556	poss	its,expression
R924	T4556	T4550	nsubjpass	expression,induced
R925	T4557	T4550	auxpass	is,induced
R926	T4604	T4601	punct	],16
R927	T4558	T4559	advmod	when,stimulated
R928	T4559	T4550	advcl	stimulated,induced
R929	T4560	T4561	amod	quiescent,cells
R930	T4561	T4559	nsubjpass	cells,stimulated
R931	T4605	T4587	punct	.,associates
R932	T4562	T4559	auxpass	are,stimulated
R933	T4563	T4564	aux	to,divide
R934	T4564	T4559	xcomp	divide,stimulated
R935	T4607	T4608	advmod	Indeed,relies
R936	T4565	T4566	punct	[,16
R937	T4566	T4559	parataxis	16,stimulated
R938	T4567	T4566	punct	],16
R939	T4568	T4550	punct	.,induced
R940	T4609	T4608	punct	", ",relies
R941	T4570	T4571	nsubj	E2f3b,is
R942	T4572	T4570	punct	", ",E2f3b
R943	T4610	T4608	csubj	silencing,relies
R944	T4573	T4570	prep	like,E2f3b
R945	T4574	T4575	amod	repressive,E2fs
R946	T4575	T4573	pobj	E2fs,like
R947	T4576	T4571	punct	", ",is
R948	T4577	T4571	acomp	present,is
R949	T4578	T4571	prep	in,is
R950	T4579	T4580	preconj	both,quiescent
R951	T4611	T4612	det	the,locus
R952	T4580	T4581	amod	quiescent,cells
R953	T4581	T4578	pobj	cells,in
R954	T4612	T4610	dobj	locus,silencing
R955	T4613	T4612	nmod	Cdkn2d,locus
R956	T4614	T4613	punct	(,Cdkn2d
R957	T4615	T4613	appos	p19Arf,Cdkn2d
R958	T4616	T4612	punct	),locus
R959	T4687	T4684	punct	],20
R960	T4617	T4610	prep	in,silencing
R961	T4688	T4679	punct	", ",affects
R962	T4689	T4679	nsubj	it,affects
R963	T4690	T4679	advmod	also,affects
R964	T4618	T4619	amod	unstressed,cells
R965	T4691	T4692	amod	activating,E2fs
R966	T4692	T4679	dobj	E2fs,affects
R967	T4619	T4617	pobj	cells,in
R968	T4693	T4694	punct	[,23
R969	T4694	T4679	parataxis	23,affects
R970	T4695	T4696	punct	–,25
R971	T4620	T4608	prep	on,relies
R972	T4696	T4694	prep	25,23
R973	T4697	T4694	punct	],23
R974	T4621	T4620	pobj	E2f3b,on
R975	T4698	T4679	punct	.,affects
R976	T4700	T4701	det	The,distribution
R977	T4622	T4623	punct	[,19
R978	T4701	T4702	nsubjpass	distribution,assessed
R979	T4623	T4608	parataxis	19,relies
R980	T4703	T4701	prep	of,distribution
R981	T4624	T4623	punct	],19
R982	T4704	T4705	compound	E2f,isoforms
R983	T4705	T4703	pobj	isoforms,of
R984	T4706	T4702	aux	has,assessed
R985	T4625	T4608	punct	.,relies
R986	T4707	T4702	neg	never,assessed
R987	T4708	T4702	auxpass	been,assessed
R988	T4709	T4702	punct	.,assessed
R989	T4627	T4628	amod	Other,E2fs
R990	T4711	T4712	nsubjpass	It,known
R991	T4628	T4629	nsubj	E2fs,exist
R992	T4713	T4712	aux	has,known
R993	T4714	T4712	auxpass	been,known
R994	T4630	T4629	aux	may,exist
R995	T4715	T4712	prep	for,known
R996	T4716	T4717	amod	many,years
R997	T4717	T4715	pobj	years,for
R998	T4718	T4719	mark	that,perturbs
R999	T4719	T4712	ccomp	perturbs,known
R1000	T4720	T4721	compound	Rb,loss
R1001	T4721	T4719	nsubj	loss,perturbs
R1002	T4722	T4723	amod	neuronal,differentiation
R1003	T4631	T4629	advmod	also,exist
R1004	T4723	T4719	dobj	differentiation,perturbs
R1005	T4724	T4725	punct	[,26
R1006	T4725	T4712	parataxis	26,known
R1007	T4632	T4629	prep	in,exist
R1008	T4726	T4727	punct	–,29
R1009	T4727	T4725	prep	29,26
R1010	T4728	T4725	punct	],26
R1011	T4633	T4632	pobj	isoforms,in
R1012	T4729	T4712	punct	.,known
R1013	T4731	T4732	advmod	However,exclude
R1014	T4634	T4635	mark	since,detected
R1015	T4733	T4732	punct	", ",exclude
R1016	T4734	T4735	amod	prior,work
R1017	T4635	T4629	advcl	detected,exist
R1018	T4735	T4732	nsubj	work,exclude
R1019	T4736	T4732	aux	could,exclude
R1020	T4737	T4732	neg	not,exclude
R1021	T4636	T4637	advmod	at,two
R1022	T4738	T4739	det	the,possibility
R1023	T4739	T4732	dobj	possibility,exclude
R1024	T4740	T4741	mark	that,are
R1025	T4637	T4639	nummod	two,mRNA
R1026	T4741	T4739	acl	are,possibility
R1027	T4742	T4743	compound	differentiation,defects
R1028	T4638	T4637	advmod	least,two
R1029	T4743	T4741	nsubj	defects,are
R1030	T4744	T4741	advmod	simply,are
R1031	T4745	T4746	det	an,consequence
R1032	T4639	T4640	compound	mRNA,species
R1033	T4746	T4741	attr	consequence,are
R1034	T4747	T4746	amod	indirect,consequence
R1035	T4748	T4746	prep	of,consequence
R1036	T4640	T4635	nsubjpass	species,detected
R1037	T4749	T4750	amod	abnormal,division
R1038	T4750	T4748	pobj	division,of
R1039	T4751	T4750	cc	and,division
R1040	T4641	T4635	aux	have,detected
R1041	T4752	T4750	conj	death,division
R1042	T4753	T4732	punct	.,exclude
R1043	T4642	T4635	auxpass	been,detected
R1044	T4755	T4756	mark	If,regulate
R1045	T4756	T4759	advcl	regulate,is
R1046	T4757	T4756	nsubj	Rb,regulate
R1047	T4643	T4635	prep	for,detected
R1048	T4758	T4756	aux	does,regulate
R1049	T4760	T4756	dobj	differentiation,regulate
R1050	T4761	T4756	advmod	directly,regulate
R1051	T4762	T4759	nsubj	it,is
R1052	T4763	T4759	acomp	unclear,is
R1053	T4644	T4643	pobj	E2f1,for
R1054	T4764	T4765	mark	whether,does
R1055	T4765	T4759	ccomp	does,is
R1056	T4766	T4765	nsubj	it,does
R1057	T4645	T4644	cc	and,E2f1
R1058	T4767	T4765	advmod	so,does
R1059	T4768	T4765	prep	in,does
R1060	T4769	T4768	pobj	all,in
R1061	T4646	T4644	conj	E2f2,E2f1
R1062	T4770	T4769	cc	or,all
R1063	T4771	T4772	det	a,subset
R1064	T4772	T4773	nmod	subset,neurons
R1065	T4647	T4648	punct	[,16
R1066	T4773	T4769	conj	neurons,all
R1067	T4774	T4772	prep	of,subset
R1068	T4648	T4635	parataxis	16,detected
R1069	T4775	T4759	punct	.,is
R1070	T4777	T4778	advmod	Moreover,solved
R1071	T4649	T4648	punct	],16
R1072	T4779	T4778	punct	", ",solved
R1073	T4780	T4781	det	the,mechanism
R1074	T4650	T4629	punct	.,exist
R1075	T4781	T4778	nsubjpass	mechanism,solved
R1076	T4782	T4778	aux	has,solved
R1077	T4783	T4778	neg	never,solved
R1078	T4652	T4653	det	The,roles
R1079	T4784	T4778	auxpass	been,solved
R1080	T4785	T4778	punct	.,solved
R1081	T4653	T4654	nsubj	roles,are
R1082	T4787	T4788	prep	In,seems
R1083	T4789	T4790	amod	other,types
R1084	T4655	T4653	prep	of,roles
R1085	T4790	T4787	pobj	types,In
R1086	T4791	T4790	compound	cell,types
R1087	T4792	T4793	advmod	where,promote
R1088	T4656	T4657	compound	E2f,isoforms
R1089	T4657	T4655	pobj	isoforms,of
R1090	T4658	T4659	advmod	in,vivo
R1091	T4659	T4653	advmod	vivo,roles
R1092	T4793	T4790	relcl	promote,types
R1093	T4794	T4793	nsubj	Rb,promote
R1094	T4795	T4793	aux	may,promote
R1095	T4660	T4654	acomp	unknown,are
R1096	T4796	T4793	dobj	differentiation,promote
R1097	T4797	T4793	advmod	directly,promote
R1098	T4661	T4654	punct	.,are
R1099	T4798	T4790	punct	", ",types
R1100	T4799	T4800	amod	such,as
R1101	T4800	T4790	prep	as,types
R1102	T4801	T4800	pobj	muscle,as
R1103	T4802	T4801	cc	and,muscle
R1104	T4663	T4664	nsubjpass	E2fs,regulated
R1105	T4803	T4801	conj	bone,muscle
R1106	T4804	T4788	punct	", ",seems
R1107	T4805	T4788	nsubj	it,seems
R1108	T4806	T4807	aux	to,do
R1109	T4807	T4788	xcomp	do,seems
R1110	T4665	T4664	auxpass	are,regulated
R1111	T4808	T4807	advmod	so,do
R1112	T4809	T4807	prep	through,do
R1113	T4810	T4811	npadvmod	E2f,independent
R1114	T4811	T4813	amod	independent,means
R1115	T4666	T4664	advmod	also,regulated
R1116	T4812	T4811	punct	-,independent
R1117	T4813	T4809	pobj	means,through
R1118	T4814	T4807	prep	by,do
R1119	T4667	T4664	agent	by,regulated
R1120	T4815	T4814	pcomp	potentiating,by
R1121	T4816	T4817	npadvmod	tissue,specific
R1122	T4817	T4819	amod	specific,factors
R1123	T4668	T4669	amod	subcellular,localization
R1124	T4818	T4817	punct	-,specific
R1125	T4819	T4815	dobj	factors,potentiating
R1126	T4820	T4819	compound	transcription,factors
R1127	T4669	T4667	pobj	localization,by
R1128	T4821	T4822	punct	(,1B
R1129	T4822	T4807	parataxis	1B,do
R1130	T4823	T4822	compound	Figure,1B
R1131	T4670	T4664	punct	.,regulated
R1132	T4824	T4822	punct	),1B
R1133	T4825	T4826	punct	[,30
R1134	T4826	T4807	parataxis	30,do
R1135	T4672	T4673	mark	Although,characterized
R1136	T4827	T4828	punct	–,33
R1137	T4828	T4826	prep	33,30
R1138	T4829	T4826	punct	],30
R1139	T4673	T4679	advcl	characterized,affects
R1140	T4830	T4788	punct	.,seems
R1141	T4832	T4833	prep	In,noted
R1142	T4674	T4675	det	this,feature
R1143	T4834	T4835	det	the,retina
R1144	T4835	T4832	pobj	retina,In
R1145	T4675	T4673	nsubjpass	feature,characterized
R1146	T4836	T4833	punct	", ",noted
R1147	T4837	T4833	nsubj	others,noted
R1148	T4838	T4833	aux	have,noted
R1149	T4676	T4673	aux	has,characterized
R1150	T4839	T4840	advmod	abnormally,shaped
R1151	T4840	T4841	amod	shaped,rods
R1152	T4841	T4833	dobj	rods,noted
R1153	T4842	T4843	compound	Rb,KO
R1154	T4843	T4841	compound	KO,rods
R1155	T4844	T4833	cc	and,noted
R1156	T4845	T4846	aux	have,suggested
R1157	T4677	T4673	auxpass	been,characterized
R1158	T4846	T4833	conj	suggested,noted
R1159	T4847	T4848	nsubj	Rb,promote
R1160	T4848	T4846	advcl	promote,suggested
R1161	T4849	T4848	aux	may,promote
R1162	T4678	T4673	advmod	best,characterized
R1163	T4850	T4848	advmod	directly,promote
R1164	T4851	T4852	poss	their,morphogenesis
R1165	T4680	T4673	prep	for,characterized
R1166	T4852	T4848	dobj	morphogenesis,promote
R1167	T4853	T4848	prep	by,promote
R1168	T4854	T4853	pcomp	activating,by
R1169	T4855	T4856	npadvmod	retina,specific
R1170	T4681	T4682	amod	repressive,E2fs
R1171	T4856	T4858	amod	specific,factors
R1172	T4857	T4856	punct	-,specific
R1173	T4858	T4854	dobj	factors,activating
R1174	T4682	T4680	pobj	E2fs,for
R1175	T4859	T4860	punct	[,29
R1176	T4860	T4848	parataxis	29,promote
R1177	T4861	T4860	punct	],29
R1178	T4683	T4684	punct	[,20
R1179	T4862	T4833	punct	.,noted
R1180	T4684	T4673	parataxis	20,characterized
R1181	T4864	T4865	advmod	However,be
R1182	T4685	T4686	punct	–,22
R1183	T4866	T4865	punct	", ",be
R1184	T4867	T4868	compound	differentiation,defects
R1185	T4868	T4865	nsubj	defects,be
R1186	T4686	T4684	prep	22,20
R1187	T4869	T4868	prep	in,defects
R1188	T4870	T4871	det	any,neuron
R1189	T4871	T4869	pobj	neuron,in
R1190	T4898	T4897	dobj	differentiation,study
R1191	T4872	T4873	compound	Rb,KO
R1192	T4873	T4871	compound	KO,neuron
R1193	T4874	T4865	aux	could,be
R1194	T4875	T4876	det	an,effect
R1195	T4876	T4865	attr	effect,be
R1196	T4899	T4898	prep	of,differentiation
R1197	T4877	T4876	amod	indirect,effect
R1198	T4878	T4876	prep	of,effect
R1199	T4900	T4901	compound	Rb,KO
R1200	T4901	T4902	compound	KO,cells
R1201	T4879	T4880	amod	ectopic,division
R1202	T4880	T4878	pobj	division,of
R1203	T4881	T4880	cc	and,division
R1204	T4902	T4899	pobj	cells,of
R1205	T4882	T4881	punct	/,and
R1206	T4883	T4881	cc	or,and
R1207	T4884	T4880	conj	apoptosis,division
R1208	T4885	T4886	punct	(,1B
R1209	T4886	T4865	parataxis	1B,be
R1210	T4887	T4886	compound	Figure,1B
R1211	T4903	T4897	prep	in,study
R1212	T4888	T4886	punct	),1B
R1213	T4889	T4865	punct	.,be
R1214	T4904	T4905	det	the,absence
R1215	T4891	T4892	advmod	Thus,is
R1216	T4893	T4892	punct	", ",is
R1217	T4905	T4903	pobj	absence,in
R1218	T4894	T4892	nsubj	it,is
R1219	T4895	T4892	acomp	critical,is
R1220	T4906	T4905	prep	of,absence
R1221	T4896	T4897	aux	to,study
R1222	T4897	T4892	xcomp	study,is
R1223	T4907	T4908	amod	ectopic,proliferation
R1224	T4908	T4906	pobj	proliferation,of
R1225	T5004	T5001	ccomp	are,revealed
R1226	T4909	T4908	cc	and,proliferation
R1227	T5005	T5006	det	these,interneurons
R1228	T5006	T5004	nsubj	interneurons,are
R1229	T5007	T5004	acomp	critical,are
R1230	T4910	T4908	conj	death,proliferation
R1231	T5008	T5007	prep	for,critical
R1232	T5009	T5010	compound	direction,selectivity
R1233	T5010	T5008	pobj	selectivity,for
R1234	T4911	T4892	punct	.,is
R1235	T5011	T5010	cc	and,selectivity
R1236	T5012	T5013	advmod	developmentally,important
R1237	T4913	T4914	advmod	Here,establish
R1238	T5013	T5014	amod	important,bursts
R1239	T5014	T5010	conj	bursts,selectivity
R1240	T5015	T5014	amod	rhythmic,bursts
R1241	T5016	T5017	punct	[,34
R1242	T5017	T5004	parataxis	34,are
R1243	T4915	T4914	punct	", ",establish
R1244	T5018	T5019	punct	–,36
R1245	T5019	T5017	prep	36,34
R1246	T5020	T5017	punct	],34
R1247	T5021	T5001	punct	.,revealed
R1248	T4916	T4914	nsubj	we,establish
R1249	T5023	T5024	advmod	However,understood
R1250	T4917	T4918	mark	that,suppresses
R1251	T5025	T5024	punct	", ",understood
R1252	T5026	T5027	poss	their,differentiation
R1253	T4918	T4914	ccomp	suppresses,establish
R1254	T5027	T5024	nsubjpass	differentiation,understood
R1255	T5028	T5024	auxpass	is,understood
R1256	T5029	T5024	advmod	poorly,understood
R1257	T5030	T5024	punct	.,understood
R1258	T5032	T5033	advcl	Contrary,show
R1259	T4919	T4918	nsubj	Rb,suppresses
R1260	T5034	T5032	prep	to,Contrary
R1261	T4920	T4921	compound	RTC,division
R1262	T5035	T5036	det	the,view
R1263	T5036	T5034	pobj	view,to
R1264	T5037	T5036	amod	prevailing,view
R1265	T4921	T4918	dobj	division,suppresses
R1266	T5038	T5039	mark	that,promotes
R1267	T5039	T5036	acl	promotes,view
R1268	T5040	T5039	nsubj	Rb,promotes
R1269	T4922	T4921	cc	and,division
R1270	T5041	T5039	dobj	differentiation,promotes
R1271	T5042	T5039	prep	through,promotes
R1272	T4923	T4921	conj	death,division
R1273	T5043	T5044	npadvmod	E2f,independent
R1274	T5044	T5046	amod	independent,factors
R1275	T5045	T5044	punct	-,independent
R1276	T4924	T4918	prep	by,suppresses
R1277	T5046	T5042	pobj	factors,through
R1278	T5047	T5048	npadvmod	tissue,specific
R1279	T5048	T5046	amod	specific,factors
R1280	T4925	T4924	pcomp	inhibiting,by
R1281	T5049	T5048	punct	-,specific
R1282	T5050	T5046	compound	transcription,factors
R1283	T4926	T4925	dobj	E2f1,inhibiting
R1284	T5051	T5033	punct	", ",show
R1285	T5052	T5033	nsubj	we,show
R1286	T5053	T5054	mark	that,facilitates
R1287	T4927	T4926	punct	", ",E2f1
R1288	T5054	T5033	ccomp	facilitates,show
R1289	T5055	T5054	nsubj	Rb,facilitates
R1290	T5056	T5057	compound	SAC,development
R1291	T4928	T4926	cc	not,E2f1
R1292	T4929	T4926	conj	E2f2,E2f1
R1293	T5057	T5054	dobj	development,facilitates
R1294	T5058	T5054	prep	through,facilitates
R1295	T4930	T4929	cc	or,E2f2
R1296	T5059	T5058	pobj	E2f3,through
R1297	T5060	T5033	punct	.,show
R1298	T4931	T4929	conj	E2f3,E2f2
R1299	T5062	T5063	nsubj	Defects,correlated
R1300	T5064	T5062	prep	in,Defects
R1301	T4932	T4914	punct	.,establish
R1302	T5065	T5066	npadvmod	Rb,null
R1303	T5066	T5067	amod	null,SACs
R1304	T5067	T5064	pobj	SACs,in
R1305	T4934	T4935	advmod	When,rescued
R1306	T5068	T5063	prep	with,correlated
R1307	T5069	T5070	amod	specific,expression
R1308	T5070	T5068	pobj	expression,with
R1309	T5071	T5070	compound	E2f3,expression
R1310	T5072	T5063	prep	in,correlated
R1311	T5073	T5074	det	these,cells
R1312	T4935	T4939	advcl	rescued,survived
R1313	T5074	T5072	pobj	cells,in
R1314	T4936	T4937	det	these,defects
R1315	T4937	T4935	nsubjpass	defects,rescued
R1316	T5075	T5063	punct	", ",correlated
R1317	T5076	T5063	cc	and,correlated
R1318	T4938	T4935	auxpass	were,rescued
R1319	T5077	T5078	compound	E2f3,expression
R1320	T5078	T5079	nsubj	expression,was
R1321	T4940	T4939	punct	", ",survived
R1322	T5079	T5063	conj	was,correlated
R1323	T5080	T5079	acomp	absent,was
R1324	T5081	T5079	prep	in,was
R1325	T5082	T5081	pobj	neurons,in
R1326	T4941	T4942	advmod	most,neurons
R1327	T5083	T5084	dep	that,differentiated
R1328	T5084	T5082	relcl	differentiated,neurons
R1329	T5085	T5084	prep	without,differentiated
R1330	T4942	T4939	nsubj	neurons,survived
R1331	T5086	T5085	pobj	Rb,without
R1332	T5087	T5079	punct	.,was
R1333	T4943	T4942	amod	retinal,neurons
R1334	T5089	T5090	nsubj	E2f3,is
R1335	T4944	T4942	punct	", ",neurons
R1336	T5091	T5090	advmod	also,is
R1337	T5092	T5090	acomp	present,is
R1338	T5093	T5090	prep	in,is
R1339	T4945	T4942	prep	including,neurons
R1340	T5094	T5095	det	a,subset
R1341	T5095	T5093	pobj	subset,in
R1342	T5096	T5095	amod	specific,subset
R1343	T4946	T4945	pobj	rods,including
R1344	T5097	T5095	prep	of,subset
R1345	T5098	T5099	amod	other,neurons
R1346	T4947	T4939	punct	", ",survived
R1347	T5099	T5097	pobj	neurons,of
R1348	T5100	T5099	compound	CNS,neurons
R1349	T5101	T5090	punct	", ",is
R1350	T4948	T4939	punct	", ",survived
R1351	T5102	T5090	advcl	implying,is
R1352	T5103	T5104	mark	that,be
R1353	T5104	T5102	ccomp	be,implying
R1354	T4949	T4939	conj	differentiated,survived
R1355	T5105	T5104	nsubj	this,be
R1356	T5106	T5104	aux	may,be
R1357	T4950	T4949	punct	", ",differentiated
R1358	T5107	T5108	det	a,mechanism
R1359	T5108	T5104	attr	mechanism,be
R1360	T5109	T5108	amod	general,mechanism
R1361	T4951	T4949	cc	and,differentiated
R1362	T4952	T4949	conj	functioned,differentiated
R1363	T5110	T5111	prep	by,facilitates
R1364	T5111	T5108	relcl	facilitates,mechanism
R1365	T5112	T5110	pobj	which,by
R1366	T5113	T5111	nsubj	Rb,facilitates
R1367	T4953	T4952	advmod	normally,functioned
R1368	T5114	T5111	dobj	neurogenesis,facilitates
R1369	T5115	T5090	punct	.,is
R1370	T4954	T4939	punct	.,survived
R1371	T5117	T5118	aux	To,define
R1372	T4956	T4957	advmod	Thus,function
R1373	T5118	T5119	advcl	define,determined
R1374	T5120	T5121	det	the,mechanism
R1375	T5121	T5118	dobj	mechanism,define
R1376	T4958	T4957	punct	", ",function
R1377	T5122	T5118	prep	in,define
R1378	T5123	T5124	advmod	even,detail
R1379	T5124	T5122	pobj	detail,in
R1380	T5125	T5124	amod	more,detail
R1381	T4959	T4957	advmod	unexpectedly,function
R1382	T5126	T5119	punct	", ",determined
R1383	T5127	T5119	nsubj	we,determined
R1384	T5128	T5129	det	which,isoform
R1385	T4960	T4957	punct	", ",function
R1386	T5129	T5131	dep	isoform,targets
R1387	T5130	T5129	compound	E2f3,isoform
R1388	T4961	T4962	npadvmod	retina,specific
R1389	T5131	T5119	ccomp	targets,determined
R1390	T5132	T5131	nsubj	Rb,targets
R1391	T5133	T5134	aux	to,control
R1392	T4962	T4964	amod	specific,factors
R1393	T5134	T5131	advcl	control,targets
R1394	T5135	T5136	compound	SAC,differentiation
R1395	T4963	T4962	punct	-,specific
R1396	T5136	T5134	dobj	differentiation,control
R1397	T5137	T5119	punct	.,determined
R1398	T4964	T4957	nsubj	factors,function
R1399	T5139	T5140	nsubj	E2f3b,mediates
R1400	T5141	T5142	compound	Rb,function
R1401	T4965	T4964	compound	differentiation,factors
R1402	T5142	T5140	dobj	function,mediates
R1403	T5143	T5140	prep	in,mediates
R1404	T4966	T4957	advmod	independently,function
R1405	T5144	T5145	amod	quiescent,fibroblasts
R1406	T5145	T5143	pobj	fibroblasts,in
R1407	T4967	T4966	prep	of,independently
R1408	T4968	T4967	pobj	Rb,of
R1409	T5146	T5147	punct	[,19
R1410	T5147	T5140	parataxis	19,mediates
R1411	T4969	T4957	punct	.,function
R1412	T5148	T5147	punct	],19
R1413	T5149	T5140	punct	", ",mediates
R1414	T5150	T5140	cc	yet,mediates
R1415	T5151	T5152	det	no,studies
R1416	T5152	T5154	nsubj	studies,dissected
R1417	T5153	T5152	amod	prior,studies
R1418	T4971	T4972	advmod	However,revealed
R1419	T5154	T5140	conj	dissected,mediates
R1420	T5155	T5154	prep	to,dissected
R1421	T5156	T5157	poss	our,knowledge
R1422	T4973	T4972	punct	", ",revealed
R1423	T5157	T5155	pobj	knowledge,to
R1424	T5158	T5154	aux	have,dissected
R1425	T5159	T5160	nmod	E2f3a,functions
R1426	T4974	T4975	amod	comprehensive,assessment
R1427	T5160	T5154	dobj	functions,dissected
R1428	T5161	T5159	cc	or,E2f3a
R1429	T5162	T5159	conj	E2f3b,E2f3a
R1430	T4975	T4972	nsubj	assessment,revealed
R1431	T5163	T5164	advmod	in,vivo
R1432	T5164	T5154	advmod	vivo,dissected
R1433	T4976	T4975	prep	of,assessment
R1434	T5165	T5154	punct	.,dissected
R1435	T5167	T5168	advcl	Using,show
R1436	T4977	T4978	det	the,retina
R1437	T5169	T5170	det	an,mouse
R1438	T4978	T4976	pobj	retina,of
R1439	T5170	T5167	dobj	mouse,Using
R1440	T5171	T5172	npadvmod	isoform,specific
R1441	T5172	T5170	amod	specific,mouse
R1442	T4979	T4980	compound	Rb,E2f1
R1443	T5173	T5172	punct	-,specific
R1444	T5174	T5170	amod	null,mouse
R1445	T5175	T5168	nsubj	we,show
R1446	T4980	T4982	npadvmod	E2f1,null
R1447	T5176	T5177	mark	that,drives
R1448	T5177	T5168	ccomp	drives,show
R1449	T5178	T5177	nsubj	Rb,drives
R1450	T4981	T4980	punct	/,E2f1
R1451	T5179	T5180	compound	SAC,differentiation
R1452	T5180	T5177	dobj	differentiation,drives
R1453	T4982	T4978	amod	null,retina
R1454	T5181	T5177	prep	through,drives
R1455	T5182	T5181	pobj	E2f3a,through
R1456	T5183	T5168	punct	.,show
R1457	T4983	T4982	amod	double,null
R1458	T5185	T5186	advmod	Thus,regulate
R1459	T4984	T4982	punct	-,null
R1460	T5187	T5186	punct	", ",regulate
R1461	T5188	T5186	advcl	independent,regulate
R1462	T4985	T4978	amod	rescued,retina
R1463	T5189	T5188	prep	of,independent
R1464	T5190	T5191	npadvmod	E2f1,mediated
R1465	T5191	T5193	amod	mediated,effects
R1466	T5192	T5191	punct	-,mediated
R1467	T5193	T5189	pobj	effects,of
R1468	T5194	T5193	prep	on,effects
R1469	T4986	T4987	det	a,defect
R1470	T5195	T5194	pobj	division,on
R1471	T5196	T5195	cc	and,division
R1472	T5197	T5195	conj	death,division
R1473	T4987	T4972	dobj	defect,revealed
R1474	T5198	T5186	punct	", ",regulate
R1475	T5199	T5186	nsubj	Rb,regulate
R1476	T4988	T4987	compound	differentiation,defect
R1477	T5200	T5186	aux	does,regulate
R1478	T5201	T5202	amod	neuronal,differentiation
R1479	T5202	T5186	dobj	differentiation,regulate
R1480	T4989	T4972	prep	in,revealed
R1481	T5203	T5186	punct	", ",regulate
R1482	T5204	T5205	dep	but,in
R1483	T4990	T4991	amod	cholinergic,cells
R1484	T5205	T5186	prep	in,regulate
R1485	T5206	T5205	advmod	only,in
R1486	T5207	T5208	amod	specific,neurons
R1487	T4991	T4989	pobj	cells,in
R1488	T5208	T5205	pobj	neurons,in
R1489	T5209	T5205	cc	and,in
R1490	T4992	T4991	nmod	starburst,cells
R1491	T5210	T5205	punct	", ",in
R1492	T5211	T5212	advmod	unexpectedly,through
R1493	T4993	T4991	amod	amacrine,cells
R1494	T5212	T5205	conj	through,in
R1495	T5213	T5212	punct	", ",through
R1496	T5214	T5212	pobj	E2f3a,through
R1497	T4994	T4991	punct	(,cells
R1498	T5215	T5214	punct	", ",E2f3a
R1499	T4995	T4991	appos	SACs,cells
R1500	T4996	T4972	punct	),revealed
R1501	T5216	T5214	cc	not,E2f3a
R1502	T5217	T5218	npadvmod	tissue,specific
R1503	T5218	T5220	amod	specific,factors
R1504	T4997	T4972	punct	.,revealed
R1505	T5219	T5218	punct	-,specific
R1506	T5220	T5214	conj	factors,E2f3a
R1507	T5221	T5220	compound	differentiation,factors
R1508	T4999	T5000	amod	Recent,breakthroughs
R1509	T5222	T5186	punct	.,regulate
R1510	T5000	T5001	nsubj	breakthroughs,revealed
R1511	T5002	T5001	aux	have,revealed
R1512	T5003	T5004	mark	that,are
R1519	T6888	T6889	nsubj	Rb,Regulates
R1520	T6890	T6889	dobj	Division,Regulates
R1521	T6891	T6890	cc	and,Division
R1522	T6892	T6890	conj	Death,Division
R1523	T6893	T6889	prep	through,Regulates
R1524	T6894	T6893	pobj	E2f1,through
R1525	T6896	T6897	nsubj	We,used
R1526	T6898	T6899	det	the,transgene
R1527	T6899	T6897	dobj	transgene,used
R1528	T6900	T6901	compound	α,Cre
R1529	T6901	T6899	compound	Cre,transgene
R1530	T6902	T6901	punct	-,Cre
R1531	T6903	T6904	aux	to,delete
R1532	T6904	T6897	advcl	delete,used
R1533	T6905	T6906	amod	floxed,exon
R1534	T6906	T6904	dobj	exon,delete
R1535	T6907	T6906	compound	Rb,exon
R1536	T6908	T6906	nummod	19,exon
R1537	T6909	T6904	prep	at,delete
R1538	T6910	T6911	amod	embryonic,day
R1539	T6911	T6909	pobj	day,at
R1540	T6912	T6911	punct	(,day
R1541	T6913	T6911	appos	E,day
R1542	T6914	T6911	punct	),day
R1543	T6915	T6911	nummod	10,day
R1544	T6916	T6904	prep	in,delete
R1545	T6917	T6918	amod	peripheral,retina
R1546	T6918	T6916	pobj	retina,in
R1547	T6919	T6920	punct	[,2
R1548	T6920	T6897	parataxis	2,used
R1549	T6921	T6920	punct	],2
R1550	T6922	T6897	punct	.,used
R1551	T6924	T6925	nmod	RbloxP,loxP
R1552	T6925	T6927	nmod	loxP,mice
R1553	T6926	T6925	punct	/,loxP
R1554	T6927	T6932	nsubjpass	mice,bred
R1555	T6928	T6925	punct	;,loxP
R1556	T6929	T6930	compound	α,Cre
R1557	T6930	T6925	appos	Cre,loxP
R1558	T6931	T6930	punct	-,Cre
R1559	T6933	T6932	auxpass	were,bred
R1560	T6934	T6932	prep	with,bred
R1561	T6935	T6934	pobj	strains,with
R1562	T6936	T6935	acl	lacking,strains
R1563	T6937	T6936	dobj	E2f1,lacking
R1564	T6938	T6937	cc	or,E2f1
R1565	T6939	T6937	conj	E2f2,E2f1
R1566	T6940	T6936	prep	in,lacking
R1567	T6941	T6942	det	the,line
R1568	T6942	T6940	pobj	line,in
R1569	T6943	T6942	compound	germ,line
R1570	T6944	T6935	punct	", ",strains
R1571	T6945	T6935	cc	or,strains
R1572	T6946	T6947	det	a,strain
R1573	T6947	T6935	conj	strain,strains
R1574	T6948	T6947	acl	carrying,strain
R1575	T6949	T6950	det	a,allele
R1576	T6950	T6948	dobj	allele,carrying
R1577	T6951	T6950	amod	floxed,allele
R1578	T6952	T6950	compound	E2f3,allele
R1579	T6953	T6954	punct	[,5
R1580	T6954	T6932	parataxis	5,bred
R1581	T6955	T6954	punct	],5
R1582	T6956	T6932	punct	.,bred
R1583	T6958	T6959	nmod	RbloxP,loxP
R1584	T6959	T6961	nmod	loxP,mice
R1585	T6960	T6959	punct	/,loxP
R1586	T6961	T6980	nsubjpass	mice,bred
R1587	T6962	T6959	punct	;,loxP
R1588	T6963	T6959	appos	E2f1,loxP
R1589	T6964	T6963	punct	+,E2f1
R1590	T6965	T6963	punct	/,E2f1
R1591	T6966	T6963	punct	−,E2f1
R1592	T6967	T6959	cc	and,loxP
R1593	T6968	T6969	compound	RbloxP,loxP
R1594	T6969	T6959	conj	loxP,loxP
R1595	T6970	T6969	punct	/,loxP
R1596	T6971	T6969	punct	;,loxP
R1597	T6972	T6969	appos	E2f1,loxP
R1598	T6973	T6972	punct	+,E2f1
R1599	T6974	T6972	punct	/,E2f1
R1600	T6975	T6972	punct	−,E2f1
R1601	T6976	T6959	punct	;,loxP
R1602	T6977	T6978	compound	α,Cre
R1603	T6978	T6959	appos	Cre,loxP
R1604	T6979	T6978	punct	-,Cre
R1605	T6981	T6980	auxpass	were,bred
R1606	T6982	T6983	aux	to,produce
R1607	T6983	T6980	advcl	produce,bred
R1608	T6984	T6985	nmod	RbloxP,loxP
R1609	T6985	T6987	nmod	loxP,mice
R1610	T6986	T6985	punct	/,loxP
R1611	T6987	T6983	dobj	mice,produce
R1612	T6988	T6985	punct	;,loxP
R1613	T6989	T6985	appos	E2f1,loxP
R1614	T6990	T6989	punct	−,E2f1
R1615	T6991	T6989	punct	/,E2f1
R1616	T6992	T6989	punct	−,E2f1
R1617	T6993	T6985	punct	;,loxP
R1618	T6994	T6995	compound	α,Cre
R1619	T6995	T6985	appos	Cre,loxP
R1620	T6996	T6995	punct	-,Cre
R1621	T6997	T6983	prep	at,produce
R1622	T6998	T6999	det	a,frequency
R1623	T6999	T6997	pobj	frequency,at
R1624	T7000	T6999	prep	of,frequency
R1625	T7001	T7002	nummod	1,8
R1626	T7002	T7000	pobj	8,of
R1627	T7003	T7002	punct	/,8
R1628	T7004	T6980	cc	and,bred
R1629	T7005	T7006	compound	littermate,controls
R1630	T7006	T6980	conj	controls,bred
R1631	T7007	T7006	prep	at,controls
R1632	T7008	T7009	det	the,same
R1633	T7009	T7007	pobj	same,at
R1634	T7010	T7009	cc	or,same
R1635	T7011	T7012	nmod	higher,frequency
R1636	T7012	T7009	conj	frequency,same
R1637	T7013	T7014	punct	(,1
R1638	T7014	T7011	parataxis	1,higher
R1639	T7015	T7016	punct	/,4
R1640	T7016	T7014	prep	4,1
R1641	T7017	T7014	punct	),1
R1642	T7018	T7006	punct	.,controls
R1643	T7020	T7021	prep	For,refer
R1644	T7022	T7020	pobj	simplicity,For
R1645	T7023	T7021	nsubj	we,refer
R1646	T7024	T7021	aux	will,refer
R1647	T7025	T7021	prep	to,refer
R1648	T7026	T7027	det	the,retina
R1649	T7027	T7025	pobj	retina,to
R1650	T7028	T7029	nmod	RbloxP,loxP
R1651	T7029	T7027	nmod	loxP,retina
R1652	T7030	T7029	punct	/,loxP
R1653	T7031	T7029	punct	;,loxP
R1654	T7032	T7029	appos	E2f1,loxP
R1655	T7033	T7032	punct	−,E2f1
R1656	T7034	T7032	punct	/,E2f1
R1657	T7035	T7032	punct	−,E2f1
R1658	T7036	T7029	punct	;,loxP
R1659	T7037	T7038	compound	α,Cre
R1660	T7038	T7029	appos	Cre,loxP
R1661	T7039	T7038	punct	-,Cre
R1662	T7040	T7027	amod	peripheral,retina
R1663	T7041	T7021	prep	as,refer
R1664	T7042	T7043	det	the,retina
R1665	T7043	T7041	pobj	retina,as
R1666	T7044	T7045	nmod	Rb,E2f1
R1667	T7045	T7043	nmod	E2f1,retina
R1668	T7046	T7045	punct	/,E2f1
R1669	T7047	T7048	amod	double,knockout
R1670	T7048	T7045	appos	knockout,E2f1
R1671	T7049	T7048	punct	(,knockout
R1672	T7050	T7048	appos	DKO,knockout
R1673	T7051	T7043	punct	),retina
R1674	T7052	T7021	punct	.,refer
R1675	T7054	T7055	amod	Similar,strategies
R1676	T7055	T7056	nsubjpass	strategies,employed
R1677	T7057	T7056	auxpass	were,employed
R1678	T7058	T7056	prep	in,employed
R1679	T7059	T7060	det	the,case
R1680	T7060	T7058	pobj	case,in
R1681	T7061	T7060	prep	of,case
R1682	T7062	T7061	pobj	E2f2,of
R1683	T7063	T7062	cc	or,E2f2
R1684	T7064	T7062	conj	E2f3,E2f2
R1685	T7065	T7056	punct	.,employed
R1686	T7067	T7068	npadvmod	Cre,mediated
R1687	T7068	T7070	amod	mediated,excision
R1688	T7069	T7068	punct	-,mediated
R1689	T7070	T7071	nsubjpass	excision,confirmed
R1690	T7072	T7070	prep	of,excision
R1691	T7073	T7074	nmod	Rb,alleles
R1692	T7074	T7072	pobj	alleles,of
R1693	T7075	T7073	cc	and,Rb
R1694	T7076	T7073	conj	E2f3,Rb
R1695	T7077	T7070	prep	in,excision
R1696	T7078	T7079	det	the,retina
R1697	T7079	T7077	pobj	retina,in
R1698	T7080	T7071	auxpass	was,confirmed
R1699	T7081	T7071	prep	by,confirmed
R1700	T7082	T7081	pobj	PCR,by
R1701	T7083	T7084	mark	as,described
R1702	T7084	T7071	advcl	described,confirmed
R1703	T7085	T7084	advmod	previously,described
R1704	T7086	T7087	punct	[,5
R1705	T7087	T7071	parataxis	5,confirmed
R1706	T7088	T7087	nummod	2,5
R1707	T7089	T7087	punct	",",5
R1708	T7090	T7087	punct	],5
R1709	T7091	T7071	punct	.,confirmed
R1710	T7093	T7094	aux	To,measure
R1711	T7094	T7095	advcl	measure,labelled
R1712	T7096	T7097	amod	ectopic,division
R1713	T7097	T7094	dobj	division,measure
R1714	T7098	T7097	compound	cell,division
R1715	T7099	T7095	punct	", ",labelled
R1716	T7100	T7095	nsubjpass	mice,labelled
R1717	T7101	T7095	auxpass	were,labelled
R1718	T7102	T7095	dep	pulse,labelled
R1719	T7103	T7095	punct	-,labelled
R1720	T7104	T7095	prep	with,labelled
R1721	T7105	T7104	pobj	bromodeoxyuridine,with
R1722	T7106	T7105	punct	(,bromodeoxyuridine
R1723	T7107	T7105	appos	BrdU,bromodeoxyuridine
R1724	T7108	T7095	punct	),labelled
R1725	T7109	T7110	nummod	2,h
R1726	T7110	T7111	npadvmod	h,before
R1727	T7111	T7095	prep	before,labelled
R1728	T7112	T7111	pobj	sacrifice,before
R1729	T7113	T7095	cc	and,labelled
R1730	T7114	T7115	det	the,retina
R1731	T7115	T7117	nsubj	retina,analyzed
R1732	T7116	T7115	amod	peripheral,retina
R1733	T7117	T7095	conj	analyzed,labelled
R1734	T7118	T7117	prep	for,analyzed
R1735	T7119	T7120	compound	BrdU,incorporation
R1736	T7120	T7118	pobj	incorporation,for
R1737	T7121	T7117	prep	by,analyzed
R1738	T7122	T7121	pobj	immunofluorescence,by
R1739	T7123	T7095	punct	.,labelled
R1740	T7125	T7126	mark	As,reported
R1741	T7126	T7127	advcl	reported,exhibited
R1742	T7128	T7126	advmod	before,reported
R1743	T7129	T7130	punct	[,3
R1744	T7130	T7126	parataxis	3,reported
R1745	T7131	T7130	nummod	2,3
R1746	T7132	T7130	punct	",",3
R1747	T7133	T7130	punct	],3
R1748	T7134	T7127	dep	", ",exhibited
R1749	T7135	T7136	compound	Rb,KO
R1750	T7136	T7137	compound	KO,retinas
R1751	T7137	T7127	nsubj	retinas,exhibited
R1752	T7138	T7139	preconj	both,spatial
R1753	T7139	T7140	amod	spatial,synthesis
R1754	T7140	T7127	dobj	synthesis,exhibited
R1755	T7141	T7139	cc	and,spatial
R1756	T7142	T7139	conj	temporal,spatial
R1757	T7143	T7140	amod	ectopic,synthesis
R1758	T7144	T7140	compound	DNA,synthesis
R1759	T7145	T7146	punct	(,1C
R1760	T7146	T7127	parataxis	1C,exhibited
R1761	T7147	T7146	compound	Figures,1C
R1762	T7148	T7146	cc	and,1C
R1763	T7149	T7146	conj	S1A,1C
R1764	T7150	T7146	punct	),1C
R1765	T7151	T7127	punct	.,exhibited
R1766	T7153	T7154	nsubjpass	This,detected
R1767	T7155	T7154	auxpass	is,detected
R1768	T7156	T7154	advmod	easily,detected
R1769	T7157	T7154	prep	at,detected
R1770	T7158	T7157	pobj	E14,at
R1771	T7159	T7158	punct	", ",E14
R1772	T7160	T7158	conj	E16,E14
R1773	T7161	T7160	punct	", ",E16
R1774	T7162	T7160	cc	and,E16
R1775	T7163	T7164	amod	postnatal,day
R1776	T7164	T7160	conj	day,E16
R1777	T7165	T7164	punct	(,day
R1778	T7166	T7164	appos	P,day
R1779	T7167	T7164	punct	),day
R1780	T7168	T7164	nummod	0,day
R1781	T7169	T7154	prep	in,detected
R1782	T7170	T7171	det	the,retina
R1783	T7171	T7169	pobj	retina,in
R1784	T7172	T7171	amod	inner,retina
R1785	T7173	T7174	advmod	where,located
R1786	T7174	T7171	relcl	located,retina
R1787	T7175	T7176	amod	abnormal,RTCs
R1788	T7176	T7174	nsubjpass	RTCs,located
R1789	T7177	T7176	nmod	BrdU,RTCs
R1790	T7178	T7177	punct	+,BrdU
R1791	T7179	T7176	nmod	ganglion,RTCs
R1792	T7180	T7179	cc	and,ganglion
R1793	T7181	T7179	conj	amacrine,ganglion
R1794	T7182	T7174	auxpass	are,located
R1795	T7183	T7169	punct	", ",in
R1796	T7184	T7169	cc	or,in
R1797	T7185	T7169	conj	on,in
R1798	T7186	T7187	det	the,region
R1799	T7187	T7185	pobj	region,on
R1800	T7188	T7187	amod	outermost,region
R1801	T7189	T7187	prep	of,region
R1802	T7190	T7191	det	the,retina
R1803	T7191	T7189	pobj	retina,of
R1804	T7192	T7191	compound	P0,retina
R1805	T7193	T7191	punct	", ",retina
R1806	T7194	T7195	advmod	where,reside
R1807	T7195	T7191	relcl	reside,retina
R1808	T7196	T7197	nmod	BrdU,RTCs
R1809	T7197	T7195	nsubj	RTCs,reside
R1810	T7198	T7196	punct	+,BrdU
R1811	T7199	T7197	compound	photoreceptor,RTCs
R1812	T7200	T7201	punct	(,arrows
R1813	T7201	T7154	parataxis	arrows,detected
R1814	T7202	T7203	compound	Figures,S1A
R1815	T7203	T7201	dep	S1A,arrows
R1816	T7204	T7203	cc	and,S1A
R1817	T7205	T7203	conj	S2,S1A
R1818	T7206	T7201	punct	", ",arrows
R1819	T7207	T7201	punct	),arrows
R1820	T7208	T7209	punct	[,2
R1821	T7209	T7154	parataxis	2,detected
R1822	T7210	T7209	punct	],2
R1823	T7211	T7154	punct	.,detected
R1824	T7213	T7214	amod	Ectopic,division
R1825	T7214	T7216	nsubj	division,is
R1826	T7215	T7214	compound	RTC,division
R1827	T7217	T7214	prep	in,division
R1828	T7218	T7219	compound	Rb,KO
R1829	T7219	T7220	compound	KO,retinas
R1830	T7220	T7217	pobj	retinas,in
R1831	T7221	T7222	advmod	even,more
R1832	T7222	T7223	advmod	more,obvious
R1833	T7223	T7216	acomp	obvious,is
R1834	T7224	T7216	prep	at,is
R1835	T7225	T7224	pobj	P8,at
R1836	T7226	T7225	cc	or,P8
R1837	T7227	T7225	conj	P18,P8
R1838	T7228	T7225	punct	", ",P8
R1839	T7229	T7230	advmod	when,completed
R1840	T7230	T7225	relcl	completed,P8
R1841	T7231	T7230	nsubjpass	division,completed
R1842	T7232	T7230	auxpass	is,completed
R1843	T7233	T7230	prep	in,completed
R1844	T7234	T7235	amod	wild,type
R1845	T7235	T7237	nmod	type,retina
R1846	T7236	T7235	punct	-,type
R1847	T7237	T7233	pobj	retina,in
R1848	T7238	T7235	punct	(,type
R1849	T7239	T7235	appos	WT,type
R1850	T7240	T7237	punct	),retina
R1851	T7241	T7242	punct	(,1C
R1852	T7242	T7216	parataxis	1C,is
R1853	T7243	T7242	compound	Figures,1C
R1854	T7244	T7242	cc	and,1C
R1855	T7245	T7242	conj	S1A,1C
R1856	T7246	T7242	punct	),1C
R1857	T7247	T7216	punct	.,is
R1858	T7249	T7250	advmod	Strikingly,suppressed
R1859	T7251	T7250	punct	", ",suppressed
R1860	T7252	T7253	det	the,cells
R1861	T7253	T7250	nsubjpass	cells,suppressed
R1862	T7254	T7255	advmod	ectopically,positioned
R1863	T7255	T7253	amod	positioned,cells
R1864	T7256	T7257	compound	S,phase
R1865	T7257	T7253	compound	phase,cells
R1866	T7258	T7257	punct	-,phase
R1867	T7259	T7253	prep	at,cells
R1868	T7260	T7259	pobj	E14,at
R1869	T7261	T7260	punct	", ",E14
R1870	T7262	T7260	conj	E16,E14
R1871	T7263	T7262	punct	", ",E16
R1872	T7264	T7262	cc	and,E16
R1873	T7265	T7262	conj	P0,E16
R1874	T7266	T7253	cc	and,cells
R1875	T7267	T7268	predet	all,division
R1876	T7268	T7253	conj	division,cells
R1877	T7269	T7268	det	the,division
R1878	T7270	T7268	amod	abnormal,division
R1879	T7271	T7268	prep	at,division
R1880	T7272	T7271	pobj	P8,at
R1881	T7273	T7272	cc	and,P8
R1882	T7274	T7272	conj	P18,P8
R1883	T7275	T7250	auxpass	were,suppressed
R1884	T7276	T7250	advmod	completely,suppressed
R1885	T7277	T7250	prep	in,suppressed
R1886	T7278	T7279	det	the,retina
R1887	T7279	T7277	pobj	retina,in
R1888	T7280	T7281	compound	Rb,E2f1
R1889	T7281	T7283	compound	E2f1,DKO
R1890	T7282	T7281	punct	/,E2f1
R1891	T7283	T7279	compound	DKO,retina
R1892	T7284	T7285	punct	(,1C
R1893	T7285	T7250	parataxis	1C,suppressed
R1894	T7286	T7285	compound	Figures,1C
R1895	T7287	T7285	punct	", ",1C
R1896	T7288	T7285	conj	1E,1C
R1897	T7289	T7288	punct	", ",1E
R1898	T7290	T7288	conj	1F,1E
R1899	T7291	T7290	punct	", ",1F
R1900	T7292	T7290	conj	S1A,1F
R1901	T7293	T7292	punct	", ",S1A
R1902	T7294	T7292	cc	and,S1A
R1903	T7295	T7292	conj	S2,S1A
R1904	T7296	T7285	punct	),1C
R1905	T7297	T7250	punct	.,suppressed
R1906	T7299	T7300	prep	In,had
R1907	T7301	T7299	pobj	contrast,In
R1908	T7302	T7300	punct	", ",had
R1909	T7303	T7300	nsubj	deletion,had
R1910	T7304	T7303	prep	of,deletion
R1911	T7305	T7304	pobj	E2f2,of
R1912	T7306	T7305	cc	or,E2f2
R1913	T7307	T7305	conj	E2f3,E2f2
R1914	T7308	T7309	det	no,effect
R1915	T7309	T7300	dobj	effect,had
R1916	T7310	T7300	prep	at,had
R1917	T7311	T7312	det	any,stage
R1918	T7312	T7310	pobj	stage,at
R1919	T7313	T7312	prep	of,stage
R1920	T7314	T7313	pobj	development,of
R1921	T7315	T7300	punct	.,had
R1922	T7317	T7318	nsubj	Analysis,confirmed
R1923	T7319	T7317	prep	of,Analysis
R1924	T7320	T7321	amod	mitotic,cells
R1925	T7321	T7319	pobj	cells,of
R1926	T7322	T7317	prep	with,Analysis
R1927	T7323	T7324	npadvmod	anti–phosphohistone,specific
R1928	T7324	T7330	amod	specific,antibodies
R1929	T7325	T7323	nummod	3,anti–phosphohistone
R1930	T7326	T7323	punct	(,anti–phosphohistone
R1931	T7327	T7323	appos	PH3,anti–phosphohistone
R1932	T7328	T7324	punct	),specific
R1933	T7329	T7324	punct	–,specific
R1934	T7330	T7322	pobj	antibodies,with
R1935	T7331	T7332	mark	that,suppressed
R1936	T7332	T7318	ccomp	suppressed,confirmed
R1937	T7333	T7332	nsubj	loss,suppressed
R1938	T7334	T7333	prep	of,loss
R1939	T7335	T7334	pobj	E2f1,of
R1940	T7336	T7335	punct	", ",E2f1
R1941	T7337	T7335	cc	but,E2f1
R1942	T7338	T7337	neg	not,but
R1943	T7339	T7335	conj	E2f2,E2f1
R1944	T7340	T7339	cc	or,E2f2
R1945	T7341	T7339	conj	E2f3,E2f2
R1946	T7342	T7332	punct	", ",suppressed
R1947	T7343	T7344	amod	ectopic,division
R1948	T7344	T7332	dobj	division,suppressed
R1949	T7345	T7346	punct	(,S3
R1950	T7346	T7318	parataxis	S3,confirmed
R1951	T7347	T7346	compound	Figure,S3
R1952	T7348	T7346	punct	),S3
R1953	T7349	T7318	punct	.,confirmed
R1954	T7351	T7352	csubj	Deleting,suppressed
R1955	T7353	T7354	nummod	one,allele
R1956	T7354	T7351	dobj	allele,Deleting
R1957	T7355	T7354	compound	E2f1,allele
R1958	T7356	T7352	advmod	partially,suppressed
R1959	T7357	T7358	amod	ectopic,phase
R1960	T7358	T7352	dobj	phase,suppressed
R1961	T7359	T7358	compound	S,phase
R1962	T7360	T7358	punct	-,phase
R1963	T7361	T7358	cc	and,phase
R1964	T7362	T7358	conj	mitosis,phase
R1965	T7363	T7352	prep	in,suppressed
R1966	T7364	T7365	compound	Rb,KO
R1967	T7365	T7366	compound	KO,RTCs
R1968	T7366	T7363	pobj	RTCs,in
R1969	T7367	T7368	punct	(,1C
R1970	T7368	T7352	parataxis	1C,suppressed
R1971	T7369	T7368	compound	Figures,1C
R1972	T7370	T7368	punct	", ",1C
R1973	T7371	T7368	conj	1E,1C
R1974	T7372	T7371	punct	", ",1E
R1975	T7373	T7371	conj	1F,1E
R1976	T7374	T7373	punct	", ",1F
R1977	T7375	T7373	conj	S1A,1F
R1978	T7376	T7375	punct	", ",S1A
R1979	T7377	T7375	conj	S2,S1A
R1980	T7378	T7377	punct	", ",S2
R1981	T7379	T7377	cc	and,S2
R1982	T7380	T7377	conj	S3,S2
R1983	T7381	T7368	punct	),1C
R1984	T7382	T7352	punct	", ",suppressed
R1985	T7383	T7352	advcl	suggesting,suppressed
R1986	T7384	T7385	mark	that,drives
R1987	T7385	T7383	ccomp	drives,suggesting
R1988	T7386	T7385	nsubj	E2f1,drives
R1989	T7387	T7388	amod	ectopic,division
R1990	T7388	T7385	dobj	division,drives
R1991	T7389	T7385	prep	in,drives
R1992	T7390	T7391	compound	Rb,KO
R1993	T7391	T7392	compound	KO,RTCs
R1994	T7392	T7389	pobj	RTCs,in
R1995	T7393	T7385	prep	in,drives
R1996	T7394	T7395	det	a,fashion
R1997	T7395	T7393	pobj	fashion,in
R1998	T7450	T7448	dobj	cells,eliminating
R1999	T7396	T7397	npadvmod	dose,dependent
R2000	T7451	T7450	amod	bipolar,cells
R2001	T7397	T7395	amod	dependent,fashion
R2002	T7452	T7451	cc	and,bipolar
R2003	T7398	T7397	punct	-,dependent
R2004	T7453	T7451	conj	ganglion,bipolar
R2005	T7454	T7455	advmod	as,as
R2006	T7455	T7450	cc	as,cells
R2007	T7399	T7352	punct	.,suppressed
R2008	T7456	T7455	advmod	well,as
R2009	T7457	T7458	amod	many,rods
R2010	T7401	T7402	det	These,data
R2011	T7458	T7450	conj	rods,cells
R2012	T7459	T7460	punct	(,2A
R2013	T7460	T7448	parataxis	2A,eliminating
R2014	T7461	T7460	compound	Figure,2A
R2015	T7402	T7403	nsubj	data,contrast
R2016	T7462	T7463	punct	–,2D
R2017	T7463	T7460	prep	2D,2A
R2018	T7404	T7403	prep	with,contrast
R2019	T7464	T7460	punct	),2A
R2020	T7465	T7466	punct	[,3
R2021	T7466	T7448	parataxis	3,eliminating
R2022	T7467	T7466	nummod	2,3
R2023	T7405	T7406	amod	previous,findings
R2024	T7468	T7466	punct	",",3
R2025	T7469	T7466	punct	],3
R2026	T7406	T7404	pobj	findings,with
R2027	T7470	T7437	punct	.,results
R2028	T7407	T7403	prep	in,contrast
R2029	T7472	T7473	det	The,loss
R2030	T7473	T7474	nsubj	loss,is
R2031	T7475	T7473	prep	of,loss
R2032	T7476	T7477	compound	Rb,KO
R2033	T7408	T7409	det	the,lens
R2034	T7409	T7407	pobj	lens,in
R2035	T7477	T7478	compound	KO,rods
R2036	T7410	T7409	cc	and,lens
R2037	T7478	T7475	pobj	rods,of
R2038	T7479	T7474	acomp	evident,is
R2039	T7480	T7474	prep	from,is
R2040	T7411	T7409	conj	CNS,lens
R2041	T7481	T7482	det	the,ONL
R2042	T7412	T7409	prep	of,lens
R2043	T7482	T7480	pobj	ONL,from
R2044	T7483	T7482	amod	thinner,ONL
R2045	T7484	T7474	punct	", ",is
R2046	T7485	T7474	cc	and,is
R2047	T7413	T7414	compound	Rb,KO
R2048	T7486	T7487	det	the,death
R2049	T7487	T7488	nsubjpass	death,detected
R2050	T7414	T7415	compound	KO,embryos
R2051	T7488	T7474	conj	detected,is
R2052	T7489	T7487	prep	of,death
R2053	T7490	T7491	det	these,cells
R2054	T7415	T7412	pobj	embryos,of
R2055	T7491	T7489	pobj	cells,of
R2056	T7492	T7493	advmod	as,as
R2057	T7416	T7409	punct	", ",lens
R2058	T7493	T7491	cc	as,cells
R2059	T7494	T7493	advmod	well,as
R2060	T7495	T7496	amod	bipolar,neurons
R2061	T7417	T7418	advmod	where,suppresses
R2062	T7496	T7491	conj	neurons,cells
R2063	T7497	T7495	cc	and,bipolar
R2064	T7498	T7495	conj	ganglion,bipolar
R2065	T7418	T7409	relcl	suppresses,lens
R2066	T7499	T7488	aux	can,detected
R2067	T7500	T7488	auxpass	be,detected
R2068	T7501	T7488	advmod	directly,detected
R2069	T7419	T7418	nsubj	deletion,suppresses
R2070	T7502	T7488	prep	by,detected
R2071	T7503	T7504	advmod	double,labelling
R2072	T7420	T7419	prep	of,deletion
R2073	T7504	T7502	pcomp	labelling,by
R2074	T7505	T7504	prep	for,labelling
R2075	T7506	T7507	amod	apoptotic,markers
R2076	T7421	T7422	det	any,E2f
R2077	T7507	T7505	pobj	markers,for
R2078	T7508	T7506	cc	and,apoptotic
R2079	T7422	T7420	pobj	E2f,of
R2080	T7509	T7510	compound	cell,type
R2081	T7510	T7512	npadvmod	type,specific
R2082	T7511	T7510	punct	-,type
R2083	T7512	T7506	conj	specific,apoptotic
R2084	T7513	T7512	punct	-,specific
R2085	T7514	T7515	punct	[,2
R2086	T7423	T7422	amod	activating,E2f
R2087	T7515	T7488	parataxis	2,detected
R2088	T7516	T7515	punct	],2
R2089	T7517	T7518	punct	(,M.
R2090	T7424	T7425	amod	ectopic,division
R2091	T7518	T7488	meta	M.,detected
R2092	T7519	T7518	nmod	P.,M.
R2093	T7425	T7418	dobj	division,suppresses
R2094	T7520	T7518	cc	and,M.
R2095	T7521	T7518	conj	R.,M.
R2096	T7522	T7521	nmod	B.,R.
R2097	T7426	T7418	prep	to,suppresses
R2098	T7523	T7521	punct	", ",R.
R2099	T7524	T7525	amod	unpublished,data
R2100	T7525	T7521	conj	data,R.
R2101	T7427	T7428	det	some,extent
R2102	T7526	T7525	punct	),data
R2103	T7527	T7488	punct	.,detected
R2104	T7428	T7426	pobj	extent,to
R2105	T7529	T7530	nsubj	Loss,is
R2106	T7429	T7430	punct	[,6
R2107	T7531	T7529	prep	of,Loss
R2108	T7532	T7533	amod	peripheral,cells
R2109	T7533	T7531	pobj	cells,of
R2110	T7430	T7418	parataxis	6,suppresses
R2111	T7534	T7535	compound	Rb,KO
R2112	T7535	T7533	compound	KO,cells
R2113	T7536	T7533	compound	ganglion,cells
R2114	T7431	T7432	punct	–,9
R2115	T7537	T7530	advmod	also,is
R2116	T7538	T7530	acomp	evident,is
R2117	T7432	T7430	prep	9,6
R2118	T7539	T7530	prep	from,is
R2119	T7540	T7539	pobj	thinning,from
R2120	T7541	T7540	prep	of,thinning
R2121	T7433	T7430	punct	],6
R2122	T7542	T7543	det	the,nerve
R2123	T7543	T7541	pobj	nerve,of
R2124	T7544	T7543	amod	optic,nerve
R2125	T7434	T7403	punct	.,contrast
R2126	T7545	T7546	punct	(,D.
R2127	T7546	T7530	meta	D.,is
R2128	T7436	T7437	nsubj	Loss,results
R2129	T7547	T7546	nmod	C.,D.
R2130	T7548	T7546	cc	and,D.
R2131	T7549	T7546	conj	R.,D.
R2132	T7550	T7549	nmod	B.,R.
R2133	T7438	T7436	prep	of,Loss
R2134	T7551	T7549	punct	", ",R.
R2135	T7552	T7553	amod	unpublished,data
R2136	T7553	T7549	conj	data,R.
R2137	T7554	T7553	punct	),data
R2138	T7555	T7530	punct	.,is
R2139	T7439	T7438	pobj	Rb,of
R2140	T7440	T7436	prep	in,Loss
R2141	T7441	T7442	det	the,retina
R2142	T7557	T7558	csubj	Deleting,blocked
R2143	T7442	T7440	pobj	retina,in
R2144	T7559	T7557	dobj	E2f1,Deleting
R2145	T7560	T7559	punct	", ",E2f1
R2146	T7443	T7437	prep	in,results
R2147	T7561	T7559	cc	but,E2f1
R2148	T7444	T7445	amod	considerable,apoptosis
R2149	T7445	T7443	pobj	apoptosis,in
R2150	T7446	T7445	compound	RTC,apoptosis
R2153	T7447	T7437	punct	", ",results
R2155	T7448	T7437	advcl	eliminating,results
R2160	T7449	T7450	amod	most,cells
R2189	T7683	T7682	cc	and,BrdU
R2190	T7684	T7685	amod	terminal,labelling
R2192	T7685	T7682	conj	labelling,BrdU
R2193	T7686	T7685	compound	dUTP,labelling
R2195	T7687	T7685	compound	nick,labelling
R2196	T7688	T7685	punct	-,labelling
R2197	T7689	T7685	compound	end,labelling
R2199	T7690	T7685	punct	(,labelling
R2200	T7691	T7685	appos	TUNEL,labelling
R2202	T7692	T7681	punct	),analyses
R2203	T7693	T7678	punct	", ",reversed
R2205	T7694	T7695	compound	E2f1,deletion
R2206	T7695	T7678	nsubj	deletion,reversed
R2207	T7696	T7678	advmod	specifically,reversed
R2209	T7697	T7698	predet	all,defects
R2211	T7698	T7678	dobj	defects,reversed
R2213	T7699	T7698	det	these,defects
R2215	T7700	T7698	amod	molecular,defects
R2216	T7701	T7678	punct	", ",reversed
R2217	T7702	T7678	cc	but,reversed
R2219	T7703	T7704	compound	E2f3,deletion
R2220	T7704	T7705	nsubj	deletion,had
R2221	T7705	T7678	conj	had,reversed
R2223	T7706	T7707	det	no,effect
R2224	T7707	T7705	dobj	effect,had
R2226	T7708	T7709	punct	(,1H
R2227	T7709	T7705	parataxis	1H,had
R2229	T7710	T7709	compound	Figure,1H
R2230	T7711	T7709	punct	),1H
R2231	T7712	T7705	punct	.,had
R2233	T7613	T7607	conj	genes,targets
R2234	T7614	T7615	dep	that,regulate
R2235	T7615	T7613	relcl	regulate,genes
R2236	T7616	T7617	det	the,cycle
R2237	T7617	T7615	dobj	cycle,regulate
R2238	T7618	T7617	compound	cell,cycle
R2239	T7619	T7617	cc	and,cycle
R2240	T7620	T7617	conj	apoptosis,cycle
R2241	T7621	T7590	punct	.,assessed
R2242	T7623	T7624	amod	Numerous,cycle
R2243	T7624	T7629	nsubjpass	cycle,regulated
R2244	T7625	T7624	amod	positive,cycle
R2245	T7626	T7625	cc	and,positive
R2246	T7627	T7625	conj	negative,positive
R2247	T7628	T7624	compound	cell,cycle
R2248	T7630	T7624	cc	and,cycle
R2249	T7631	T7632	amod	apoptotic,regulators
R2250	T7632	T7624	conj	regulators,cycle
R2251	T7633	T7629	auxpass	were,regulated
R2252	T7634	T7629	advmod	up,regulated
R2253	T7635	T7629	punct	-,regulated
R2254	T7636	T7629	prep	in,regulated
R2255	T7637	T7638	det	the,retina
R2256	T7638	T7636	pobj	retina,in
R2257	T7639	T7640	compound	Rb,KO
R2258	T7640	T7638	compound	KO,retina
R2259	T7641	T7642	punct	(,1H
R2260	T7642	T7629	parataxis	1H,regulated
R2261	T7643	T7642	compound	Figure,1H
R2262	T7644	T7642	punct	),1H
R2263	T7645	T7629	punct	.,regulated
R2264	T7647	T7648	prep	Among,induced
R2265	T7649	T7650	det	the,family
R2266	T7650	T7647	pobj	family,Among
R2267	T7651	T7650	compound	E2f,family
R2268	T7652	T7648	punct	", ",induced
R2269	T7653	T7648	nsubjpass	E2f1,induced
R2270	T7654	T7653	punct	", ",E2f1
R2271	T7655	T7653	conj	E2f2,E2f1
R2272	T7656	T7655	punct	", ",E2f2
R2273	T7657	T7655	conj	E2f3a,E2f2
R2274	T7658	T7657	punct	", ",E2f3a
R2275	T7659	T7657	cc	and,E2f3a
R2276	T7660	T7657	conj	E2f7,E2f3a
R2277	T7661	T7648	auxpass	were,induced
R2278	T7662	T7648	prep	following,induced
R2279	T7663	T7664	compound	Rb,loss
R2280	T7664	T7662	pobj	loss,following
R2281	T7665	T7648	punct	", ",induced
R2282	T7666	T7648	cc	but,induced
R2283	T7667	T7668	nsubj	E2f3b,were
R2284	T7668	T7648	conj	were,induced
R2285	T7669	T7667	punct	", ",E2f3b
R2286	T7670	T7667	conj	E2f4,E2f3b
R2287	T7671	T7670	punct	", ",E2f4
R2288	T7672	T7670	cc	and,E2f4
R2289	T7673	T7670	conj	E2f5,E2f4
R2290	T7674	T7668	acomp	unaffected,were
R2291	T7675	T7668	punct	.,were
R2292	T7677	T7678	advcl	Consistent,reversed
R2293	T7679	T7677	prep	with,Consistent
R2294	T7680	T7681	det	the,analyses
R2295	T7681	T7679	pobj	analyses,with
R2296	T7682	T7681	nmod	BrdU,analyses
R2308	T9110	T9111	amod	Normal,Differentiation
R2309	T9112	T9111	prep	in,Differentiation
R2310	T9113	T9114	det	the,Retina
R2311	T9114	T9112	pobj	Retina,in
R2312	T9115	T9116	compound	Rb,E2f1
R2313	T9116	T9118	compound	E2f1,DKO
R2314	T9117	T9116	punct	/,E2f1
R2315	T9118	T9114	compound	DKO,Retina
R2316	T9120	T9121	mark	Because,blocks
R2317	T9121	T9124	advcl	blocks,provided
R2318	T9122	T9123	compound	E2f1,deletion
R2319	T9123	T9121	nsubj	deletion,blocks
R2320	T9125	T9126	amod	abnormal,division
R2321	T9126	T9121	dobj	division,blocks
R2322	T9127	T9126	cc	and,division
R2323	T9128	T9126	conj	death,division
R2324	T9129	T9121	prep	in,blocks
R2325	T9130	T9131	det	the,retina
R2326	T9131	T9129	pobj	retina,in
R2327	T9132	T9133	compound	Rb,KO
R2328	T9133	T9131	compound	KO,retina
R2329	T9134	T9124	punct	", ",provided
R2330	T9135	T9136	det	the,retina
R2331	T9136	T9124	nsubj	retina,provided
R2332	T9137	T9138	compound	Rb,E2f1
R2333	T9138	T9140	compound	E2f1,DKO
R2334	T9139	T9138	punct	/,E2f1
R2335	T9140	T9136	compound	DKO,retina
R2336	T9141	T9142	det	a,opportunity
R2337	T9142	T9124	dobj	opportunity,provided
R2338	T9143	T9142	amod	unique,opportunity
R2339	T9144	T9145	aux	to,evaluate
R2340	T9145	T9142	acl	evaluate,opportunity
R2341	T9146	T9147	mark	whether,controls
R2342	T9147	T9145	ccomp	controls,evaluate
R2343	T9148	T9147	nsubj	Rb,controls
R2344	T9149	T9147	dobj	differentiation,controls
R2345	T9150	T9147	advcl	independent,controls
R2346	T9151	T9150	prep	of,independent
R2347	T9152	T9153	compound	cell,cycle
R2348	T9153	T9154	compound	cycle,effects
R2349	T9154	T9151	pobj	effects,of
R2350	T9155	T9124	punct	.,provided
R2351	T9157	T9158	det	The,retina
R2352	T9158	T9163	nsubj	retina,had
R2353	T9159	T9160	compound	Rb,E2f1
R2354	T9160	T9162	compound	E2f1,DKO
R2355	T9161	T9160	punct	/,E2f1
R2356	T9162	T9158	compound	DKO,retina
R2357	T9164	T9165	amod	many,photoreceptors
R2358	T9165	T9163	dobj	photoreceptors,had
R2359	T9166	T9165	nmod	Sag,photoreceptors
R2360	T9167	T9166	punct	+,Sag
R2361	T9168	T9166	punct	(,Sag
R2362	T9169	T9170	compound	S,arrestin
R2363	T9170	T9166	appos	arrestin,Sag
R2364	T9171	T9170	punct	-,arrestin
R2365	T9172	T9170	compound	antigen,arrestin
R2366	T9173	T9170	punct	/,arrestin
R2367	T9174	T9170	compound	rod,arrestin
R2368	T9175	T9165	punct	),photoreceptors
R2369	T9176	T9165	punct	", ",photoreceptors
R2370	T9177	T9178	nmod	Pou4f2,cells
R2371	T9178	T9165	conj	cells,photoreceptors
R2372	T9179	T9177	punct	+,Pou4f2
R2373	T9180	T9177	punct	(,Pou4f2
R2374	T9181	T9177	appos	Brn3b,Pou4f2
R2375	T9182	T9177	punct	),Pou4f2
R2376	T9183	T9178	compound	ganglion,cells
R2377	T9184	T9178	punct	", ",cells
R2378	T9185	T9178	cc	and,cells
R2379	T9186	T9187	amod	numerous,neurons
R2380	T9187	T9178	conj	neurons,cells
R2381	T9188	T9187	nmod	Prkca,neurons
R2382	T9189	T9188	punct	+,Prkca
R2383	T9190	T9188	punct	/,Prkca
R2384	T9191	T9188	appos	Cabp5,Prkca
R2385	T9192	T9191	punct	+,Cabp5
R2386	T9193	T9187	amod	bipolar,neurons
R2387	T9194	T9195	punct	(,2A
R2388	T9195	T9163	parataxis	2A,had
R2389	T9196	T9195	compound	Figure,2A
R2390	T9197	T9198	punct	–,2D
R2391	T9198	T9195	prep	2D,2A
R2392	T9199	T9195	punct	),2A
R2393	T9200	T9163	punct	.,had
R2394	T9202	T9203	prep	In,was
R2395	T9204	T9202	pobj	contrast,In
R2396	T9205	T9203	punct	", ",was
R2397	T9206	T9203	expl	there,was
R2398	T9207	T9208	det	no,rescue
R2399	T9208	T9203	attr	rescue,was
R2400	T9209	T9208	amod	such,rescue
R2401	T9210	T9208	prep	of,rescue
R2402	T9211	T9212	compound	cell,types
R2403	T9212	T9210	pobj	types,of
R2404	T9213	T9208	prep	in,rescue
R2405	T9214	T9215	nmod	Rb,E2f2
R2406	T9215	T9217	nmod	E2f2,DKO
R2407	T9216	T9215	punct	/,E2f2
R2408	T9217	T9222	compound	DKO,retinas
R2409	T9218	T9215	cc	or,E2f2
R2410	T9219	T9220	nmod	Rb,E2f3
R2411	T9220	T9215	conj	E2f3,E2f2
R2412	T9221	T9220	punct	/,E2f3
R2413	T9222	T9213	pobj	retinas,in
R2414	T9223	T9224	punct	(,S4
R2415	T9224	T9203	parataxis	S4,was
R2416	T9225	T9224	compound	Figure,S4
R2417	T9226	T9224	punct	),S4
R2418	T9227	T9203	punct	.,was
R2419	T9229	T9230	nsubj	Analysis,confirmed
R2420	T9231	T9229	prep	with,Analysis
R2421	T9232	T9233	amod	general,Mtap2
R2422	T9233	T9231	pobj	Mtap2,with
R2423	T9234	T9233	amod	neuronal,Mtap2
R2424	T9235	T9233	compound	markers,Mtap2
R2425	T9236	T9233	punct	(,Mtap2
R2426	T9237	T9233	appos	MAP2,Mtap2
R2427	T9238	T9233	punct	),Mtap2
R2428	T9239	T9233	cc	and,Mtap2
R2429	T9240	T9233	conj	Snap25,Mtap2
R2430	T9241	T9233	punct	", ",Mtap2
R2431	T9242	T9243	advmod	as,as
R2432	T9243	T9233	cc	as,Mtap2
R2433	T9244	T9243	advmod	well,as
R2434	T9245	T9246	amod	other,markers
R2435	T9246	T9233	conj	markers,Mtap2
R2436	T9247	T9246	acl	expressed,markers
R2437	T9248	T9247	prep	in,expressed
R2438	T9249	T9250	amod	bipolar,cells
R2439	T9250	T9248	pobj	cells,in
R2440	T9251	T9246	punct	(,markers
R2441	T9252	T9246	appos	Chx10,markers
R2442	T9253	T9252	punct	", ",Chx10
R2443	T9254	T9252	conj	Rcvrn,Chx10
R2444	T9255	T9254	punct	", ",Rcvrn
R2445	T9256	T9254	conj	Vsx1,Rcvrn
R2446	T9257	T9256	punct	", ",Vsx1
R2447	T9258	T9256	conj	Tacr3,Vsx1
R2448	T9259	T9258	punct	", ",Tacr3
R2449	T9260	T9258	cc	and,Tacr3
R2450	T9261	T9258	conj	Atp2b1,Tacr3
R2451	T9262	T9246	punct	),markers
R2452	T9263	T9246	cc	and,markers
R2453	T9264	T9265	compound	rod,photoreceptors
R2454	T9265	T9246	conj	photoreceptors,markers
R2455	T9266	T9265	punct	(,photoreceptors
R2456	T9267	T9265	appos	Rho,photoreceptors
R2457	T9268	T9267	cc	and,Rho
R2458	T9269	T9267	conj	Rcvrn,Rho
R2459	T9270	T9230	punct	),confirmed
R2460	T9271	T9230	dobj	rescue,confirmed
R2461	T9272	T9271	prep	of,rescue
R2462	T9273	T9274	det	the,retina
R2463	T9274	T9272	pobj	retina,of
R2464	T9275	T9276	compound	Rb,E2f1
R2465	T9276	T9278	compound	E2f1,DKO
R2466	T9277	T9276	punct	/,E2f1
R2467	T9278	T9274	compound	DKO,retina
R2468	T9279	T9280	punct	(,S1
R2469	T9280	T9230	parataxis	S1,confirmed
R2470	T9281	T9280	compound	Table,S1
R2471	T9282	T9280	punct	),S1
R2472	T9283	T9230	punct	.,confirmed
R2473	T9285	T9286	advmod	Moreover,exhibited
R2474	T9287	T9286	punct	", ",exhibited
R2475	T9288	T9286	nsubj	neurons,exhibited
R2476	T9289	T9290	det	the,morphology
R2477	T9290	T9286	dobj	morphology,exhibited
R2478	T9291	T9290	amod	same,morphology
R2479	T9292	T9290	compound	complex,morphology
R2480	T9293	T9290	prep	as,morphology
R2481	T9294	T9293	prep	in,as
R2482	T9295	T9296	compound	WT,retina
R2483	T9296	T9294	pobj	retina,in
R2484	T9297	T9286	punct	.,exhibited
R2485	T9299	T9300	amod	Bipolar,bodies
R2486	T9300	T9302	nsubjpass	bodies,located
R2487	T9301	T9300	compound	cell,bodies
R2488	T9303	T9302	auxpass	were,located
R2489	T9304	T9302	prep	in,located
R2490	T9305	T9306	det	the,INL
R2491	T9306	T9304	pobj	INL,in
R2492	T9307	T9302	cc	and,located
R2493	T9308	T9302	conj	had,located
R2494	T9309	T9310	amod	ascending,processes
R2495	T9310	T9308	dobj	processes,had
R2496	T9311	T9309	cc	and,ascending
R2497	T9312	T9309	conj	descending,ascending
R2498	T9313	T9310	acl	ending,processes
R2499	T9314	T9313	prep	in,ending
R2500	T9315	T9316	det	the,OPL
R2501	T9316	T9314	pobj	OPL,in
R2502	T9317	T9316	cc	and,OPL
R2503	T9318	T9316	conj	IPL,OPL
R2504	T9319	T9308	punct	", ",had
R2505	T9320	T9308	advmod	respectively,had
R2506	T9321	T9322	punct	(,2A
R2507	T9322	T9308	parataxis	2A,had
R2508	T9323	T9322	compound	Figure,2A
R2509	T9324	T9322	punct	),2A
R2510	T9325	T9302	punct	.,located
R2511	T9327	T9328	prep	In,had
R2512	T9329	T9327	pobj	addition,In
R2513	T9330	T9328	punct	", ",had
R2514	T9331	T9332	det	the,retina
R2515	T9332	T9328	nsubj	retina,had
R2516	T9333	T9334	compound	Rb,E2f1
R2517	T9334	T9336	compound	E2f1,DKO
R2518	T9335	T9334	punct	/,E2f1
R2519	T9336	T9332	compound	DKO,retina
R2520	T9337	T9338	det	a,ONL
R2521	T9338	T9328	dobj	ONL,had
R2522	T9339	T9340	amod	healthy,appearing
R2523	T9340	T9338	amod	appearing,ONL
R2524	T9341	T9338	acl	consisting,ONL
R2525	T9342	T9341	prep	of,consisting
R2526	T9343	T9344	advmod	morphologically,normal
R2527	T9344	T9345	amod	normal,rods
R2528	T9345	T9342	pobj	rods,of
R2529	T9346	T9328	prep	with,had
R2530	T9347	T9348	amod	descending,processes
R2531	T9348	T9346	pobj	processes,with
R2532	T9349	T9348	acl	ending,processes
R2533	T9350	T9349	prep	in,ending
R2534	T9351	T9352	det	the,OPL
R2535	T9352	T9350	pobj	OPL,in
R2536	T9353	T9348	cc	and,processes
R2537	T9354	T9355	amod	ascending,processes
R2538	T9355	T9348	conj	processes,processes
R2539	T9356	T9357	dep	that,terminated
R2540	T9357	T9355	relcl	terminated,processes
R2541	T9358	T9357	prep	in,terminated
R2542	T9359	T9360	amod	inner,segments
R2543	T9360	T9358	pobj	segments,in
R2544	T9361	T9359	cc	and,inner
R2545	T9362	T9359	conj	outer,inner
R2546	T9363	T9364	punct	(,2A
R2547	T9364	T9328	parataxis	2A,had
R2548	T9365	T9364	compound	Figure,2A
R2549	T9366	T9364	punct	),2A
R2550	T9367	T9328	punct	.,had
R2551	T9369	T9370	nsubjpass	It,suggested
R2552	T9371	T9370	auxpass	was,suggested
R2553	T9372	T9373	mark	that,regulate
R2554	T9373	T9370	ccomp	regulate,suggested
R2555	T9374	T9373	nsubj	Rb,regulate
R2556	T9375	T9373	aux	might,regulate
R2557	T9376	T9377	compound	photoreceptor,differentiation
R2558	T9377	T9373	dobj	differentiation,regulate
R2559	T9378	T9373	punct	", ",regulate
R2560	T9379	T9380	advmod	possibly,through
R2561	T9380	T9373	prep	through,regulate
R2562	T9381	T9382	npadvmod	rod,specific
R2563	T9382	T9384	amod	specific,factors
R2564	T9383	T9382	punct	-,specific
R2565	T9384	T9380	pobj	factors,through
R2566	T9385	T9384	compound	transcription,factors
R2567	T9386	T9387	punct	(,1B
R2568	T9387	T9370	parataxis	1B,suggested
R2569	T9388	T9387	compound	Figure,1B
R2570	T9389	T9387	punct	),1B
R2571	T9390	T9391	punct	[,29
R2572	T9391	T9370	parataxis	29,suggested
R2573	T9392	T9391	punct	],29
R2574	T9393	T9370	punct	.,suggested
R2575	T9395	T9396	advmod	However,does
R2576	T9397	T9396	punct	", ",does
R2577	T9398	T9399	mark	if,regulate
R2578	T9399	T9396	advcl	regulate,does
R2579	T9400	T9399	nsubj	Rb,regulate
R2580	T9401	T9399	aux	does,regulate
R2581	T9402	T9403	compound	photoreceptor,differentiation
R2582	T9403	T9399	dobj	differentiation,regulate
R2583	T9404	T9396	punct	", ",does
R2584	T9405	T9396	nsubj	it,does
R2585	T9406	T9396	advmod	so,does
R2586	T9407	T9396	prep	by,does
R2587	T9408	T9407	pcomp	inhibiting,by
R2588	T9409	T9408	dobj	E2f1,inhibiting
R2589	T9410	T9407	punct	", ",by
R2590	T9411	T9407	cc	not,by
R2591	T9412	T9407	conj	by,by
R2592	T9413	T9412	pcomp	potentiating,by
R2593	T9414	T9415	compound	rod,differentiation
R2594	T9415	T9416	compound	differentiation,factors
R2595	T9416	T9413	dobj	factors,potentiating
R2596	T9417	T9416	punct	", ",factors
R2597	T9418	T9419	amod	such,as
R2598	T9419	T9416	prep	as,factors
R2599	T9420	T9419	pobj	Otx2,as
R2600	T9421	T9420	punct	", ",Otx2
R2601	T9422	T9420	conj	Crx,Otx2
R2602	T9423	T9422	punct	", ",Crx
R2603	T9424	T9422	cc	or,Crx
R2604	T9425	T9422	conj	Nrl,Crx
R2605	T9426	T9396	punct	.,does
R2606	T9428	T9429	nsubj	It,is
R2607	T9430	T9429	acomp	impossible,is
R2608	T9431	T9432	aux	to,tell
R2609	T9432	T9429	xcomp	tell,is
R2610	T9433	T9434	mark	whether,perturbs
R2611	T9434	T9432	ccomp	perturbs,tell
R2612	T9435	T9434	nsubj	E2f1,perturbs
R2613	T9436	T9434	dobj	differentiation,perturbs
R2614	T9437	T9434	advmod	directly,perturbs
R2615	T9438	T9434	punct	", ",perturbs
R2616	T9439	T9434	prep	by,perturbs
R2617	T9440	T9439	pcomp	affecting,by
R2618	T9441	T9442	det	the,expression
R2619	T9442	T9440	dobj	expression,affecting
R2620	T9443	T9442	prep	of,expression
R2621	T9444	T9443	pobj	genes,of
R2622	T9445	T9446	dep	that,modulate
R2623	T9446	T9444	relcl	modulate,genes
R2624	T9447	T9446	dobj	maturation,modulate
R2625	T9448	T9434	punct	", ",perturbs
R2626	T9449	T9434	cc	and,perturbs
R2627	T9450	T9449	punct	/,and
R2628	T9451	T9449	cc	or,and
R2629	T9452	T9453	advmod	indirectly,1B
R2630	T9453	T9434	conj	1B,perturbs
R2631	T9454	T9453	prep	through,1B
R2632	T9455	T9456	poss	its,effects
R2633	T9456	T9454	pobj	effects,through
R2634	T9457	T9456	prep	on,effects
R2635	T9458	T9457	pobj	proliferation,on
R2636	T9459	T9458	cc	and,proliferation
R2637	T9460	T9458	conj	survival,proliferation
R2638	T9461	T9453	punct	(,1B
R2639	T9462	T9453	compound	Figure,1B
R2640	T9463	T9453	punct	),1B
R2641	T9464	T9429	punct	.,is
R2642	T9466	T9467	prep	As,was
R2643	T9468	T9466	prep	with,As
R2644	T9469	T9470	amod	ectopic,division
R2645	T9470	T9468	pobj	division,with
R2646	T9471	T9470	cc	and,division
R2647	T9472	T9470	conj	apoptosis,division
R2648	T9473	T9474	punct	(,1C
R2649	T9474	T9470	parataxis	1C,division
R2650	T9475	T9474	compound	Figure,1C
R2651	T9476	T9474	cc	and,1C
R2652	T9477	T9474	conj	1D,1C
R2653	T9478	T9474	punct	),1C
R2654	T9479	T9467	punct	", ",was
R2655	T9480	T9481	det	the,rescue
R2656	T9481	T9467	nsubj	rescue,was
R2657	T9482	T9481	prep	of,rescue
R2658	T9483	T9484	nmod	Rb,KO
R2659	T9484	T9485	nmod	KO,cells
R2660	T9485	T9482	pobj	cells,of
R2661	T9486	T9485	nmod	retinal,cells
R2662	T9487	T9485	amod	bipolar,cells
R2663	T9488	T9487	punct	", ",bipolar
R2664	T9489	T9487	conj	ganglion,bipolar
R2665	T9490	T9489	punct	", ",ganglion
R2666	T9491	T9489	cc	and,ganglion
R2667	T9492	T9489	conj	rod,ganglion
R2668	T9493	T9467	acomp	dependent,was
R2669	T9494	T9493	prep	on,dependent
R2670	T9495	T9496	compound	E2f1,dose
R2671	T9496	T9494	pobj	dose,on
R2672	T9497	T9498	punct	(,2A
R2673	T9498	T9467	parataxis	2A,was
R2674	T9499	T9498	compound	Figure,2A
R2675	T9500	T9501	punct	–,2D
R2676	T9501	T9498	prep	2D,2A
R2677	T9502	T9498	punct	),2A
R2678	T9503	T9467	punct	.,was
R2679	T9505	T9506	advcl	Separate,promotes
R2680	T9507	T9505	prep	from,Separate
R2681	T9508	T9509	poss	its,role
R2682	T9509	T9507	pobj	role,from
R2683	T9510	T9509	prep	in,role
R2684	T9511	T9510	pcomp	driving,in
R2685	T9512	T9513	amod	ectopic,division
R2686	T9513	T9511	dobj	division,driving
R2687	T9514	T9513	prep	of,division
R2688	T9515	T9516	compound	Rb,KO
R2689	T9516	T9517	compound	KO,RTCs
R2690	T9517	T9514	pobj	RTCs,of
R2691	T9518	T9506	punct	", ",promotes
R2692	T9519	T9506	nsubj	E2f1,promotes
R2693	T9520	T9506	advmod	also,promotes
R2694	T9521	T9522	amod	normal,division
R2695	T9522	T9506	dobj	division,promotes
R2696	T9523	T9522	compound	RPC,division
R2697	T9524	T9525	mark	since,drops
R2698	T9525	T9506	advcl	drops,promotes
R2699	T9526	T9525	prep	in,drops
R2700	T9527	T9528	poss	its,absence
R2701	T9528	T9526	pobj	absence,in
R2702	T9529	T9530	compound	RPC,proliferation
R2703	T9530	T9525	nsubj	proliferation,drops
R2704	T9531	T9532	punct	~,2
R2705	T9532	T9525	npadvmod	2,drops
R2706	T9533	T9532	punct	-,2
R2707	T9534	T9532	advmod	fold,2
R2708	T9535	T9536	punct	(,D.
R2709	T9536	T9506	meta	D.,promotes
R2710	T9537	T9536	nmod	C.,D.
R2711	T9538	T9536	cc	and,D.
R2712	T9539	T9536	conj	R.,D.
R2713	T9540	T9539	nmod	B.,R.
R2714	T9541	T9539	punct	", ",R.
R2715	T9542	T9543	amod	unpublished,data
R2716	T9543	T9539	conj	data,R.
R2717	T9544	T9543	punct	),data
R2718	T9545	T9506	punct	.,promotes
R2719	T9547	T9548	det	This,reduction
R2720	T9548	T9550	nsubj	reduction,accounts
R2721	T9549	T9548	amod	modest,reduction
R2722	T9551	T9548	prep	of,reduction
R2723	T9552	T9553	compound	RPC,numbers
R2724	T9553	T9551	pobj	numbers,of
R2725	T9554	T9548	prep	in,reduction
R2726	T9555	T9556	det	the,absence
R2727	T9556	T9554	pobj	absence,in
R2728	T9557	T9556	prep	of,absence
R2729	T9558	T9557	pobj	E2f1,of
R2730	T9559	T9550	prep	for,accounts
R2731	T9560	T9561	det	the,reduction
R2732	T9561	T9559	pobj	reduction,for
R2733	T9562	T9561	amod	slight,reduction
R2734	T9563	T9561	prep	in,reduction
R2735	T9564	T9565	det	the,number
R2736	T9565	T9563	pobj	number,in
R2737	T9566	T9565	prep	of,number
R2738	T9567	T9568	compound	ganglion,cells
R2739	T9568	T9566	pobj	cells,of
R2740	T9569	T9565	prep	at,number
R2741	T9570	T9569	pobj	P0,at
R2742	T9571	T9563	punct	", ",in
R2743	T9572	T9563	conj	in,in
R2744	T9573	T9574	det	the,number
R2745	T9574	T9572	pobj	number,in
R2746	T9575	T9574	prep	of,number
R2747	T9576	T9577	amod	bipolar,cells
R2748	T9577	T9575	pobj	cells,of
R2749	T9578	T9574	prep	at,number
R2750	T9579	T9578	pobj	P18,at
R2751	T9580	T9579	cc	or,P18
R2752	T9581	T9579	conj	P30,P18
R2753	T9582	T9572	punct	", ",in
R2754	T9583	T9572	cc	and,in
R2755	T9584	T9572	conj	in,in
R2756	T9585	T9586	det	the,thickness
R2757	T9586	T9584	pobj	thickness,in
R2758	T9587	T9586	prep	of,thickness
R2759	T9588	T9589	det	the,ONL
R2760	T9589	T9587	pobj	ONL,of
R2761	T9590	T9586	prep	at,thickness
R2762	T9591	T9590	pobj	P18,at
R2763	T9592	T9591	cc	or,P18
R2764	T9593	T9591	conj	P30,P18
R2765	T9594	T9586	prep	in,thickness
R2766	T9595	T9596	det	the,retina
R2767	T9596	T9594	pobj	retina,in
R2768	T9597	T9598	nmod	E2f1,KO
R2769	T9598	T9596	nmod	KO,retina
R2770	T9599	T9598	cc	and,KO
R2771	T9600	T9601	compound	Rb,E2f1
R2772	T9601	T9603	compound	E2f1,DKO
R2773	T9602	T9601	punct	/,E2f1
R2774	T9603	T9598	conj	DKO,KO
R2775	T9604	T9605	punct	(,2B
R2776	T9605	T9550	parataxis	2B,accounts
R2777	T9606	T9605	compound	Figure,2B
R2778	T9607	T9608	punct	–,2D
R2779	T9608	T9605	prep	2D,2B
R2780	T9609	T9605	punct	),2B
R2781	T9610	T9550	punct	.,accounts
R2782	T9612	T9613	det	The,morphology
R2783	T9613	T9614	nsubj	morphology,was
R2784	T9615	T9613	prep	of,morphology
R2785	T9616	T9617	compound	E2f1,KO
R2786	T9617	T9618	compound	KO,neurons
R2787	T9618	T9615	pobj	neurons,of
R2788	T9619	T9614	attr	WT,was
R2789	T9620	T9621	punct	(,2A
R2790	T9621	T9614	parataxis	2A,was
R2791	T9622	T9621	compound	Figure,2A
R2792	T9623	T9621	punct	),2A
R2793	T9624	T9614	punct	.,was
R2794	T9626	T9627	prep	Despite,was
R2795	T9628	T9629	det	a,drop
R2796	T9629	T9626	pobj	drop,Despite
R2797	T9630	T9629	amod	slight,drop
R2798	T9631	T9629	prep	in,drop
R2799	T9632	T9633	amod	absolute,numbers
R2800	T9633	T9631	pobj	numbers,in
R2801	T9634	T9633	compound	cell,numbers
R2802	T9635	T9627	punct	", ",was
R2803	T9636	T9637	det	the,proportion
R2804	T9637	T9627	nsubj	proportion,was
R2805	T9638	T9637	prep	of,proportion
R2806	T9639	T9640	nmod	Rb,E2f1
R2807	T9640	T9642	nmod	E2f1,DKO
R2808	T9641	T9640	punct	/,E2f1
R2809	T9642	T9643	nmod	DKO,cells
R2810	T9643	T9638	pobj	cells,of
R2811	T9644	T9642	cc	and,DKO
R2812	T9645	T9646	compound	E2f1,KO
R2813	T9646	T9642	conj	KO,DKO
R2814	T9647	T9643	amod	bipolar,cells
R2815	T9648	T9649	det	the,same
R2816	T9649	T9627	attr	same,was
R2817	T9650	T9649	prep	as,same
R2818	T9651	T9650	pobj	WT,as
R2819	T9652	T9653	punct	(,shown
R2820	T9653	T9627	parataxis	shown,was
R2821	T9654	T9653	nsubj	data,shown
R2822	T9655	T9653	neg	not,shown
R2823	T9656	T9653	punct	),shown
R2824	T9657	T9627	punct	.,was
R2825	T9659	T9660	advmod	Slightly,reduced
R2826	T9660	T9661	amod	reduced,numbers
R2827	T9661	T9663	nsubj	numbers,were
R2828	T9662	T9661	compound	cell,numbers
R2829	T9664	T9663	neg	not,were
R2830	T9665	T9663	prep	due,were
R2831	T9666	T9665	pcomp	to,due
R2832	T9667	T9668	amod	residual,death
R2833	T9668	T9665	pobj	death,due
R2834	T9669	T9668	compound	RTC,death
R2835	T9670	T9671	mark	since,observed
R2836	T9671	T9663	advcl	observed,were
R2837	T9672	T9671	nsubj	we,observed
R2838	T9673	T9671	aux	have,observed
R2839	T9674	T9671	neg	not,observed
R2840	T9675	T9676	amod	ectopic,apoptosis
R2841	T9676	T9671	dobj	apoptosis,observed
R2842	T9677	T9671	prep	at,observed
R2843	T9678	T9679	det	any,stage
R2844	T9679	T9677	pobj	stage,at
R2845	T9680	T9679	amod	embryonic,stage
R2846	T9681	T9680	cc	or,embryonic
R2847	T9682	T9680	conj	postnatal,embryonic
R2848	T9683	T9671	prep	in,observed
R2849	T9684	T9685	det	the,retina
R2850	T9685	T9683	pobj	retina,in
R2851	T9686	T9685	amod	developing,retina
R2852	T9687	T9688	compound	Rb,E2f1
R2853	T9688	T9690	compound	E2f1,DKO
R2854	T9689	T9688	punct	/,E2f1
R2855	T9690	T9685	compound	DKO,retina
R2856	T9691	T9692	punct	(,1D
R2857	T9692	T9671	parataxis	1D,observed
R2858	T9693	T9692	compound	Figures,1D
R2859	T9694	T9692	punct	", ",1D
R2860	T9695	T9692	conj	1G,1D
R2861	T9696	T9695	punct	", ",1G
R2862	T9697	T9695	cc	and,1G
R2863	T9698	T9695	conj	S2,1G
R2864	T9699	T9692	punct	),1D
R2865	T9700	T9663	punct	.,were
R2866	T9702	T9703	advmod	Moreover,reduces
R2867	T9704	T9703	punct	", ",reduces
R2868	T9705	T9703	csubj	deleting,reduces
R2869	T9706	T9705	dobj	Ccnd1,deleting
R2870	T9707	T9706	punct	", ",Ccnd1
R2871	T9708	T9709	dep	which,acts
R2872	T9709	T9706	relcl	acts,Ccnd1
R2873	T9710	T9709	advmod	upstream,acts
R2874	T9711	T9710	prep	of,upstream
R2875	T9712	T9713	compound	Rb,proteins
R2876	T9713	T9711	pobj	proteins,of
R2877	T9714	T9703	punct	", ",reduces
R2878	T9715	T9703	advmod	also,reduces
R2879	T9716	T9717	compound	RPC,number
R2880	T9717	T9703	dobj	number,reduces
R2881	T9718	T9703	punct	", ",reduces
R2882	T9719	T9703	cc	but,reduces
R2883	T9720	T9721	aux	does,suppress
R2884	T9721	T9703	conj	suppress,reduces
R2885	T9722	T9721	neg	not,suppress
R2886	T9723	T9724	det	any,defect
R2887	T9724	T9721	dobj	defect,suppress
R2888	T9725	T9724	prep	in,defect
R2889	T9726	T9727	det	the,retina
R2890	T9727	T9725	pobj	retina,in
R2891	T9728	T9729	compound	Rb,KO
R2892	T9729	T9727	compound	KO,retina
R2893	T9730	T9731	punct	(,D.
R2894	T9731	T9721	meta	D.,suppress
R2895	T9732	T9731	nmod	C.,D.
R2896	T9733	T9731	cc	and,D.
R2897	T9734	T9731	conj	R.,D.
R2898	T9735	T9734	nmod	B.,R.
R2899	T9736	T9734	punct	", ",R.
R2900	T9737	T9738	amod	unpublished,data
R2901	T9738	T9734	conj	data,R.
R2902	T9739	T9738	punct	),data
R2903	T9740	T9703	punct	.,reduces
R2904	T9742	T9743	advmod	Thus,are
R2905	T9744	T9743	punct	", ",are
R2906	T9745	T9746	advmod	slightly,reduced
R2907	T9746	T9747	amod	reduced,division
R2908	T9747	T9743	nsubj	division,are
R2909	T9748	T9747	compound	RPC,division
R2910	T9749	T9747	cc	and,division
R2911	T9750	T9751	amod	dramatic,rescue
R2912	T9751	T9747	conj	rescue,division
R2913	T9752	T9751	prep	of,rescue
R2914	T9753	T9754	amod	severe,defects
R2915	T9754	T9752	pobj	defects,of
R2916	T9755	T9751	prep	in,rescue
R2917	T9756	T9757	compound	Rb,KO
R2918	T9757	T9758	compound	KO,RTCs
R2919	T9758	T9755	pobj	RTCs,in
R2920	T9759	T9760	amod	distinct,effects
R2921	T9760	T9743	attr	effects,are
R2922	T9761	T9760	acl	stemming,effects
R2923	T9762	T9761	prep	from,stemming
R2924	T9763	T9764	det	the,deletion
R2925	T9764	T9762	pobj	deletion,from
R2926	T9765	T9764	prep	of,deletion
R2927	T9766	T9765	pobj	E2f1,of
R2928	T9767	T9743	punct	.,are
R2937	T11029	T11030	amod	Normal,Function
R2938	T11031	T11030	prep	of,Function
R2939	T11032	T11033	det	the,Retina
R2940	T11033	T11031	pobj	Retina,of
R2941	T11034	T11035	compound	Rb,E2f1
R2942	T11035	T11037	compound	E2f1,DKO
R2943	T11036	T11035	punct	/,E2f1
R2944	T11037	T11033	compound	DKO,Retina
R2945	T11039	T11040	det	The,discovery
R2946	T11040	T11041	nsubj	discovery,is
R2947	T11042	T11043	mark	that,rescues
R2948	T11043	T11040	acl	rescues,discovery
R2949	T11044	T11045	compound	E2f1,loss
R2950	T11045	T11043	nsubj	loss,rescues
R2951	T11046	T11047	advmod	even,morphology
R2952	T11047	T11043	dobj	morphology,rescues
R2953	T11048	T11047	det	the,morphology
R2954	T11049	T11047	prep	of,morphology
R2955	T11050	T11051	compound	Rb,KO
R2956	T11051	T11052	compound	KO,neurons
R2957	T11052	T11049	pobj	neurons,of
R2958	T11053	T11041	acomp	surprising,is
R2959	T11054	T11055	mark	because,thought
R2960	T11055	T11041	advcl	thought,is
R2961	T11056	T11055	nsubjpass	Rb,thought
R2962	T11057	T11055	auxpass	is,thought
R2963	T11058	T11059	aux	to,regulate
R2964	T11059	T11055	xcomp	regulate,thought
R2965	T11060	T11059	dobj	differentiation,regulate
R2966	T11061	T11062	advmod	primarily,through
R2967	T11062	T11059	prep	through,regulate
R2968	T11063	T11064	npadvmod	E2f,independent
R2969	T11064	T11066	amod	independent,pathways
R2970	T11065	T11064	punct	-,independent
R2971	T11066	T11062	pobj	pathways,through
R2972	T11067	T11068	punct	[,30
R2973	T11068	T11041	parataxis	30,is
R2974	T11069	T11070	punct	–,33
R2975	T11070	T11068	prep	33,30
R2976	T11071	T11068	punct	],30
R2977	T11072	T11041	punct	.,is
R2978	T11074	T11075	advmod	However,equate
R2979	T11076	T11075	punct	", ",equate
R2980	T11077	T11078	amod	normal,morphology
R2981	T11078	T11075	nsubj	morphology,equate
R2982	T11079	T11075	aux	may,equate
R2983	T11080	T11075	neg	not,equate
R2984	T11081	T11075	prep	to,equate
R2985	T11082	T11083	advmod	completely,normal
R2986	T11083	T11084	amod	normal,differentiation
R2987	T11084	T11081	pobj	differentiation,to
R2988	T11085	T11075	punct	.,equate
R2989	T11087	T11088	advmod	Thus,compared
R2990	T11089	T11088	punct	", ",compared
R2991	T11090	T11088	nsubj	we,compared
R2992	T11091	T11092	det	the,electroretinograms
R2993	T11092	T11088	dobj	electroretinograms,compared
R2994	T11093	T11092	punct	(,electroretinograms
R2995	T11094	T11092	appos	ERGs,electroretinograms
R2996	T11095	T11092	punct	),electroretinograms
R2997	T11096	T11092	prep	of,electroretinograms
R2998	T11097	T11098	amod	adult,mice
R2999	T11098	T11096	pobj	mice,of
R3000	T11099	T11098	nmod	WT,mice
R3001	T11100	T11099	punct	(,WT
R3002	T11101	T11102	compound	α,Cre
R3003	T11102	T11099	appos	Cre,WT
R3004	T11103	T11102	punct	-,Cre
R3005	T11104	T11099	punct	),WT
R3006	T11105	T11099	punct	", ",WT
R3007	T11106	T11099	conj	E2f1,WT
R3008	T11107	T11106	punct	−,E2f1
R3009	T11108	T11106	punct	/,E2f1
R3010	T11109	T11106	punct	−,E2f1
R3011	T11110	T11106	punct	", ",E2f1
R3012	T11111	T11112	compound	α,Cre
R3013	T11112	T11106	conj	Cre,E2f1
R3014	T11113	T11112	punct	-,Cre
R3015	T11114	T11112	punct	;,Cre
R3016	T11115	T11116	compound	RbloxP,loxP
R3017	T11116	T11112	appos	loxP,Cre
R3018	T11117	T11116	punct	/,loxP
R3019	T11118	T11112	punct	", ",Cre
R3020	T11119	T11112	cc	and,Cre
R3021	T11120	T11121	compound	α,Cre
R3022	T11121	T11112	conj	Cre,Cre
R3023	T11122	T11121	punct	-,Cre
R3024	T11123	T11121	punct	;,Cre
R3025	T11124	T11125	compound	RbloxP,loxP
R3026	T11125	T11121	appos	loxP,Cre
R3027	T11126	T11125	punct	/,loxP
R3028	T11127	T11121	punct	;,Cre
R3029	T11128	T11121	appos	E2f1,Cre
R3030	T11129	T11128	punct	−,E2f1
R3031	T11130	T11128	punct	/,E2f1
R3032	T11131	T11128	punct	−,E2f1
R3033	T11132	T11088	punct	.,compared
R3034	T11134	T11135	nsubj	ERGs,assess
R3035	T11136	T11135	advmod	functionally,assess
R3036	T11137	T11138	amod	visual,signalling
R3037	T11138	T11135	dobj	signalling,assess
R3038	T11139	T11138	prep	in,signalling
R3039	T11140	T11141	det	the,retina
R3040	T11141	T11139	pobj	retina,in
R3041	T11142	T11141	amod	mammalian,retina
R3042	T11143	T11138	prep	from,signalling
R3043	T11144	T11143	pobj	photoreceptors,from
R3044	T11145	T11143	prep	to,from
R3045	T11146	T11147	amod	amacrine,cells
R3046	T11147	T11145	pobj	cells,to
R3047	T11148	T11147	punct	(,cells
R3048	T11149	T11147	cc	but,cells
R3049	T11150	T11151	advmod	usually,not
R3050	T11151	T11152	neg	not,cells
R3051	T11152	T11147	conj	cells,cells
R3052	T11153	T11152	compound	gangion,cells
R3053	T11154	T11135	punct	),assess
R3054	T11155	T11135	punct	", ",assess
R3055	T11156	T11135	cc	and,assess
R3056	T11157	T11158	auxpass	are,dominated
R3057	T11158	T11135	conj	dominated,assess
R3058	T11159	T11158	agent	by,dominated
R3059	T11160	T11161	nmod	rod,cells
R3060	T11161	T11159	pobj	cells,by
R3061	T11162	T11160	cc	and,rod
R3062	T11163	T11160	conj	cone,rod
R3063	T11164	T11161	amod	bipolar,cells
R3064	T11165	T11135	punct	.,assess
R3065	T11167	T11168	advmod	Typically,begins
R3066	T11169	T11168	punct	", ",begins
R3067	T11170	T11171	det	an,signal
R3068	T11171	T11168	nsubj	signal,begins
R3069	T11172	T11171	compound	ERG,signal
R3070	T11173	T11168	prep	with,begins
R3071	T11174	T11175	det	a,deflection
R3072	T11175	T11173	pobj	deflection,with
R3073	T11176	T11175	amod	negative,deflection
R3074	T11177	T11175	acl	initiated,deflection
R3075	T11178	T11177	agent	by,initiated
R3076	T11179	T11180	det	the,photoreceptors
R3077	T11180	T11178	pobj	photoreceptors,by
R3078	T11181	T11175	punct	(,deflection
R3079	T11182	T11183	det	the,wave
R3080	T11183	T11175	appos	wave,deflection
R3081	T11184	T11183	compound	a,wave
R3082	T11185	T11183	punct	-,wave
R3083	T11186	T11175	punct	),deflection
R3084	T11187	T11175	punct	", ",deflection
R3085	T11188	T11189	dep	which,terminated
R3086	T11189	T11175	relcl	terminated,deflection
R3087	T11190	T11189	auxpass	is,terminated
R3088	T11191	T11189	agent	by,terminated
R3089	T11192	T11193	det	a,deflection
R3090	T11193	T11191	pobj	deflection,by
R3091	T11194	T11193	amod	large,deflection
R3092	T11195	T11193	amod	positive,deflection
R3093	T11196	T11189	prep	due,terminated
R3094	T11197	T11196	pcomp	to,due
R3095	T11198	T11199	det	the,activation
R3096	T11199	T11196	pobj	activation,due
R3097	T11200	T11199	prep	of,activation
R3098	T11201	T11202	nmod	ON,cells
R3099	T11202	T11200	pobj	cells,of
R3100	T11203	T11202	amod	bipolar,cells
R3101	T11204	T11189	punct	(,terminated
R3102	T11205	T11206	det	the,wave
R3103	T11206	T11189	dobj	wave,terminated
R3104	T11207	T11206	compound	b,wave
R3105	T11208	T11206	punct	-,wave
R3106	T11209	T11168	punct	),begins
R3107	T11210	T11168	punct	.,begins
R3108	T11212	T11213	nsubj	Responses,assess
R3109	T11214	T11212	prep	to,Responses
R3110	T11215	T11216	amod	dim,light
R3111	T11216	T11214	pobj	light,to
R3112	T11217	T11212	prep	in,Responses
R3113	T11218	T11219	npadvmod	dark,adapted
R3114	T11219	T11221	amod	adapted,conditions
R3115	T11220	T11219	punct	-,adapted
R3116	T11221	T11217	pobj	conditions,in
R3117	T11222	T11223	punct	(,scotopic
R3118	T11223	T11219	parataxis	scotopic,adapted
R3119	T11224	T11223	punct	),scotopic
R3120	T11225	T11213	advmod	specifically,assess
R3121	T11226	T11227	det	the,system
R3122	T11227	T11213	dobj	system,assess
R3123	T11228	T11227	compound	rod,system
R3124	T11229	T11213	punct	", ",assess
R3125	T11230	T11213	cc	and,assess
R3126	T11231	T11213	conj	were,assess
R3127	T11232	T11231	acomp	defective,were
R3128	T11233	T11231	prep	in,were
R3129	T11234	T11235	det	the,retina
R3130	T11235	T11233	pobj	retina,in
R3131	T11236	T11237	compound	Rb,KO
R3132	T11237	T11235	compound	KO,retina
R3133	T11238	T11239	punct	(,2E
R3134	T11239	T11231	parataxis	2E,were
R3135	T11240	T11239	compound	Figure,2E
R3136	T11241	T11239	punct	),2E
R3137	T11242	T11213	punct	.,assess
R3138	T11244	T11245	det	The,reduction
R3139	T11245	T11247	nsubj	reduction,is
R3140	T11246	T11245	amod	substantial,reduction
R3141	T11248	T11245	prep	of,reduction
R3142	T11249	T11250	preconj	both,a
R3143	T11250	T11251	nmod	a,waves
R3144	T11251	T11248	pobj	waves,of
R3145	T11252	T11250	punct	-,a
R3146	T11253	T11250	cc	and,a
R3147	T11254	T11250	conj	b,a
R3148	T11255	T11251	punct	-,waves
R3149	T11256	T11247	acomp	consistent,is
R3150	T11257	T11256	prep	with,consistent
R3151	T11258	T11259	nmod	rod,apoptosis
R3152	T11259	T11257	pobj	apoptosis,with
R3153	T11260	T11258	cc	and,rod
R3154	T11261	T11262	amod	bipolar,cell
R3155	T11262	T11258	conj	cell,rod
R3156	T11263	T11264	punct	[,2
R3157	T11264	T11247	parataxis	2,is
R3158	T11265	T11264	punct	],2
R3159	T11266	T11247	punct	.,is
R3160	T11268	T11269	det	The,sensitivity
R3161	T11269	T11270	nsubj	sensitivity,appeared
R3162	T11271	T11269	prep	of,sensitivity
R3163	T11272	T11273	det	the,response
R3164	T11273	T11271	pobj	response,of
R3165	T11274	T11273	amod	residual,response
R3166	T11275	T11270	oprd	unchanged,appeared
R3167	T11276	T11270	punct	", ",appeared
R3168	T11277	T11270	advcl	suggesting,appeared
R3169	T11278	T11279	nsubj	it,arose
R3170	T11279	T11277	advcl	arose,suggesting
R3171	T11280	T11279	prep	from,arose
R3172	T11281	T11282	det	the,portions
R3173	T11282	T11280	pobj	portions,from
R3174	T11283	T11284	npadvmod	Cre,negative
R3175	T11284	T11282	amod	negative,portions
R3176	T11285	T11284	punct	-,negative
R3177	T11286	T11282	prep	of,portions
R3178	T11287	T11288	det	the,retina
R3179	T11288	T11286	pobj	retina,of
R3180	T11289	T11270	punct	.,appeared
R3181	T11291	T11292	nsubj	Responses,were
R3182	T11293	T11294	advmod	about,same
R3183	T11294	T11292	attr	same,were
R3184	T11295	T11294	det	the,same
R3185	T11296	T11292	prep	in,were
R3186	T11297	T11298	det	the,retina
R3187	T11298	T11296	pobj	retina,in
R3188	T11299	T11298	nmod	WT,retina
R3189	T11300	T11299	cc	and,WT
R3190	T11301	T11302	compound	E2f1,KO
R3191	T11302	T11299	conj	KO,WT
R3192	T11303	T11292	punct	", ",were
R3193	T11304	T11292	cc	and,were
R3194	T11305	T11292	punct	", ",were
R3195	T11306	T11307	advmod	most,importantly
R3196	T11307	T11308	advmod	importantly,lay
R3197	T11308	T11292	conj	lay,were
R3198	T11309	T11308	punct	", ",lay
R3199	T11310	T11308	advmod	also,lay
R3200	T11311	T11312	det	the,response
R3201	T11312	T11308	nsubj	response,lay
R3202	T11313	T11314	compound	Rb,E2f1
R3203	T11314	T11316	compound	E2f1,DKO
R3204	T11315	T11314	punct	/,E2f1
R3205	T11316	T11312	compound	DKO,response
R3206	T11317	T11312	amod	median,response
R3207	T11318	T11308	prep	at,lay
R3208	T11319	T11320	det	the,end
R3209	T11320	T11318	pobj	end,at
R3210	T11321	T11320	amod	lower,end
R3211	T11322	T11320	prep	of,end
R3212	T11323	T11324	det	the,range
R3213	T11324	T11322	pobj	range,of
R3214	T11325	T11324	amod	normal,range
R3215	T11326	T11308	prep	for,lay
R3216	T11327	T11328	amod	most,intensities
R3217	T11328	T11326	pobj	intensities,for
R3218	T11329	T11330	punct	(,2F
R3219	T11330	T11308	parataxis	2F,lay
R3220	T11331	T11330	compound	Figure,2F
R3221	T11332	T11330	punct	),2F
R3222	T11333	T11308	punct	.,lay
R3223	T11335	T11336	advmod	Thus,rescued
R3224	T11337	T11336	punct	", ",rescued
R3225	T11338	T11339	compound	E2f1,deletion
R3226	T11339	T11336	nsubj	deletion,rescued
R3227	T11340	T11341	advmod	almost,completely
R3228	T11341	T11336	advmod	completely,rescued
R3229	T11342	T11343	det	the,system
R3230	T11343	T11336	dobj	system,rescued
R3231	T11344	T11343	compound	rod,system
R3232	T11345	T11336	prep	in,rescued
R3233	T11346	T11347	det	the,retina
R3234	T11347	T11345	pobj	retina,in
R3235	T11348	T11349	compound	Rb,KO
R3236	T11349	T11347	compound	KO,retina
R3237	T11350	T11336	punct	.,rescued
R3238	T11352	T11353	npadvmod	Light,adapted
R3239	T11353	T11355	amod	adapted,recordings
R3240	T11354	T11353	punct	-,adapted
R3241	T11355	T11359	nsubj	recordings,yielded
R3242	T11356	T11357	punct	(,photopic
R3243	T11357	T11353	parataxis	photopic,adapted
R3244	T11358	T11357	punct	),photopic
R3245	T11360	T11361	aux	to,assess
R3246	T11361	T11355	advcl	assess,recordings
R3247	T11362	T11361	advmod	specifically,assess
R3248	T11363	T11364	det	the,system
R3249	T11364	T11361	dobj	system,assess
R3250	T11365	T11364	compound	cone,system
R3251	T11366	T11367	amod	comparable,results
R3252	T11367	T11359	dobj	results,yielded
R3253	T11368	T11359	punct	.,yielded
R3254	T11370	T11371	nsubj	Cones,represent
R3255	T11372	T11373	advmod	only,3
R3256	T11373	T11374	nummod	3,%
R3257	T11374	T11371	dobj	%,represent
R3258	T11375	T11374	prep	of,%
R3259	T11376	T11375	pobj	photoreceptors,of
R3260	T11377	T11371	cc	and,represent
R3261	T11378	T11371	punct	", ",represent
R3262	T11379	T11380	prep	unlike,develop
R3263	T11380	T11371	conj	develop,represent
R3264	T11381	T11379	pobj	rods,unlike
R3265	T11382	T11380	punct	", ",develop
R3266	T11383	T11380	prep	without,develop
R3267	T11384	T11383	pobj	Rb,without
R3268	T11385	T11371	punct	", ",represent
R3269	T11386	T11371	cc	but,represent
R3270	T11387	T11388	nsubj	they,require
R3271	T11388	T11371	conj	require,represent
R3272	T11389	T11388	dobj	rods,require
R3273	T11390	T11388	prep	for,require
R3274	T11391	T11390	pobj	survival,for
R3275	T11392	T11388	punct	", ",require
R3276	T11393	T11388	cc	and,require
R3277	T11394	T11395	prep	in,have
R3278	T11395	T11388	conj	have,require
R3279	T11396	T11397	det	the,retina
R3280	T11397	T11394	pobj	retina,in
R3281	T11398	T11399	compound	Rb,KO
R3282	T11399	T11397	compound	KO,retina
R3283	T11400	T11395	punct	", ",have
R3284	T11401	T11395	nsubj	they,have
R3285	T11402	T11403	amod	abnormal,morphology
R3286	T11403	T11395	dobj	morphology,have
R3287	T11404	T11395	cc	and,have
R3288	T11405	T11406	poss	their,targets
R3289	T11406	T11408	nsubj	targets,are
R3290	T11407	T11406	amod	synaptic,targets
R3291	T11408	T11395	conj	are,have
R3292	T11409	T11406	punct	", ",targets
R3293	T11410	T11411	amod	bipolar,cells
R3294	T11411	T11406	appos	cells,targets
R3295	T11412	T11408	punct	", ",are
R3296	T11413	T11414	advmod	much,depleted
R3297	T11414	T11408	acomp	depleted,are
R3298	T11415	T11416	punct	[,2
R3299	T11416	T11408	parataxis	2,are
R3300	T11417	T11416	punct	],2
R3301	T11418	T11408	punct	.,are
R3302	T11420	T11421	det	The,response
R3303	T11421	T11423	nsubjpass	response,reduced
R3304	T11422	T11421	amod	photopic,response
R3305	T11424	T11421	punct	", ",response
R3306	T11425	T11426	det	a,product
R3307	T11426	T11421	appos	product,response
R3308	T11427	T11426	prep	of,product
R3309	T11428	T11429	nmod	cone,activity
R3310	T11429	T11427	pobj	activity,of
R3311	T11430	T11428	cc	and,cone
R3312	T11431	T11432	advmod	mainly,bipolar
R3313	T11432	T11428	conj	bipolar,cone
R3314	T11433	T11423	punct	", ",reduced
R3315	T11434	T11423	auxpass	was,reduced
R3316	T11435	T11423	advmod	much,reduced
R3317	T11436	T11423	agent	by,reduced
R3318	T11437	T11438	compound	Rb,loss
R3319	T11438	T11436	pobj	loss,by
R3320	T11439	T11423	punct	", ",reduced
R3321	T11440	T11423	cc	but,reduced
R3322	T11441	T11442	auxpass	was,rescued
R3323	T11442	T11423	conj	rescued,reduced
R3324	T11443	T11442	advmod	considerably,rescued
R3325	T11444	T11442	prep	in,rescued
R3326	T11445	T11446	det	the,retina
R3327	T11446	T11444	pobj	retina,in
R3328	T11447	T11448	compound	Rb,E2f1
R3329	T11448	T11450	compound	E2f1,DKO
R3330	T11449	T11448	punct	/,E2f1
R3331	T11450	T11446	compound	DKO,retina
R3332	T11451	T11452	punct	(,S5
R3333	T11452	T11442	parataxis	S5,rescued
R3334	T11453	T11452	compound	Figure,S5
R3335	T11454	T11452	punct	),S5
R3336	T11455	T11423	punct	.,reduced
R3337	T11457	T11458	advmod	Again,lay
R3338	T11459	T11458	punct	", ",lay
R3339	T11460	T11461	det	the,amplitude
R3340	T11461	T11458	nsubj	amplitude,lay
R3341	T11462	T11461	amod	median,amplitude
R3342	T11463	T11458	prep	at,lay
R3343	T11464	T11465	det	the,end
R3344	T11465	T11463	pobj	end,at
R3345	T11466	T11465	amod	lower,end
R3346	T11467	T11465	prep	of,end
R3347	T11468	T11469	det	the,range
R3348	T11469	T11467	pobj	range,of
R3349	T11470	T11471	compound	E2f1,KO
R3350	T11471	T11469	compound	KO,range
R3351	T11472	T11458	punct	.,lay
R3352	T11474	T11475	det	The,response
R3353	T11475	T11477	nsubjpass	response,reduced
R3354	T11476	T11475	amod	photopic,response
R3355	T11478	T11475	prep	in,response
R3356	T11479	T11480	compound	E2f1,KO
R3357	T11480	T11481	compound	KO,mice
R3358	T11481	T11478	pobj	mice,in
R3359	T11482	T11477	auxpass	was,reduced
R3360	T11483	T11477	advmod	slightly,reduced
R3361	T11484	T11477	advcl	relative,reduced
R3362	T11485	T11484	prep	to,relative
R3363	T11486	T11485	pobj	WT,to
R3364	T11487	T11488	punct	(,S5B
R3365	T11488	T11477	parataxis	S5B,reduced
R3366	T11489	T11488	compound	Figure,S5B
R3367	T11490	T11488	punct	),S5B
R3368	T11491	T11477	punct	", ",reduced
R3369	T11492	T11493	advmod	possibly,required
R3370	T11493	T11477	advcl	required,reduced
R3371	T11494	T11493	mark	because,required
R3372	T11495	T11493	nsubjpass	E2f1,required
R3373	T11496	T11493	auxpass	is,required
R3374	T11497	T11493	prep	for,required
R3375	T11498	T11499	amod	maximal,expansion
R3376	T11499	T11497	pobj	expansion,for
R3377	T11500	T11499	prep	of,expansion
R3378	T11501	T11502	amod	embryonic,RPCs
R3379	T11502	T11500	pobj	RPCs,of
R3380	T11503	T11477	punct	", ",reduced
R3381	T11504	T11477	cc	and,reduced
R3382	T11505	T11506	det	the,retina
R3383	T11506	T11509	nsubj	retina,has
R3384	T11507	T11508	compound	E2f1,KO
R3385	T11508	T11506	compound	KO,retina
R3386	T11509	T11477	conj	has,reduced
R3387	T11510	T11509	punct	", ",has
R3388	T11511	T11512	mark	as,noted
R3389	T11512	T11509	advcl	noted,has
R3390	T11513	T11512	advmod	earlier,noted
R3391	T11514	T11509	punct	", ",has
R3392	T11515	T11516	advmod	slightly,fewer
R3393	T11516	T11517	amod	fewer,cells
R3394	T11517	T11509	dobj	cells,has
R3395	T11518	T11517	prep	than,cells
R3396	T11519	T11520	det	the,retina
R3397	T11520	T11518	pobj	retina,than
R3398	T11521	T11520	compound	WT,retina
R3399	T11522	T11509	punct	", ",has
R3400	T11523	T11524	mark	although,are
R3401	T11524	T11509	advcl	are,has
R3402	T11525	T11526	compound	cell,type
R3403	T11526	T11527	compound	type,proportions
R3404	T11527	T11524	nsubj	proportions,are
R3405	T11528	T11524	acomp	unaffected,are
R3406	T11529	T11530	punct	(,D.
R3407	T11530	T11509	meta	D.,has
R3408	T11531	T11530	nmod	C.,D.
R3409	T11532	T11530	cc	and,D.
R3410	T11533	T11530	conj	R.,D.
R3411	T11534	T11533	nmod	B.,R.
R3412	T11535	T11533	punct	", ",R.
R3413	T11536	T11537	amod	unpublished,data
R3414	T11537	T11533	conj	data,R.
R3415	T11538	T11537	punct	),data
R3416	T11539	T11509	punct	.,has
R3417	T11541	T11542	advmod	Thus,attributed
R3418	T11543	T11542	punct	", ",attributed
R3419	T11544	T11545	advmod	marginally,subnormal
R3420	T11545	T11546	amod	subnormal,responses
R3421	T11546	T11542	nsubjpass	responses,attributed
R3422	T11547	T11546	amod	photopic,responses
R3423	T11548	T11546	prep	in,responses
R3424	T11549	T11550	det	the,retina
R3425	T11550	T11548	pobj	retina,in
R3426	T11551	T11552	compound	Rb,E2f1
R3427	T11552	T11554	compound	E2f1,DKO
R3428	T11553	T11552	punct	/,E2f1
R3429	T11554	T11550	compound	DKO,retina
R3430	T11555	T11542	aux	can,attributed
R3431	T11556	T11542	auxpass	be,attributed
R3432	T11557	T11542	prep	to,attributed
R3433	T11558	T11559	preconj	both,reduction
R3434	T11559	T11557	pobj	reduction,to
R3435	T11560	T11559	det	a,reduction
R3436	T11561	T11559	prep	of,reduction
R3437	T11562	T11563	compound	cone,numbers
R3438	T11563	T11561	pobj	numbers,of
R3439	T11564	T11559	prep	in,reduction
R3440	T11565	T11566	compound	E2f1,KO
R3441	T11566	T11567	compound	KO,mice
R3442	T11567	T11564	pobj	mice,in
R3443	T11568	T11567	advmod	alone,mice
R3444	T11569	T11559	punct	", ",reduction
R3445	T11570	T11559	cc	and,reduction
R3446	T11571	T11572	det	a,reduction
R3447	T11572	T11559	conj	reduction,reduction
R3448	T11573	T11572	punct	“,reduction
R3449	T11574	T11572	amod	genuine,reduction
R3450	T11575	T11572	punct	”,reduction
R3451	T11576	T11572	amod	slight,reduction
R3452	T11577	T11572	prep	in,reduction
R3453	T11578	T11579	compound	cone,function
R3454	T11579	T11577	pobj	function,in
R3455	T11580	T11572	amod	attributable,reduction
R3456	T11581	T11580	prep	to,attributable
R3457	T11582	T11583	compound	Rb,loss
R3458	T11583	T11581	pobj	loss,to
R3459	T11584	T11572	amod	relative,reduction
R3460	T11585	T11584	prep	to,relative
R3461	T11586	T11585	pobj	WT,to
R3462	T11587	T11542	punct	.,attributed
R3463	T11589	T11590	det	This,effect
R3464	T11590	T11592	nsubj	effect,relate
R3465	T11591	T11590	amod	slight,effect
R3466	T11593	T11592	aux	may,relate
R3467	T11594	T11592	prep	to,relate
R3468	T11595	T11596	det	a,defect
R3469	T11596	T11594	pobj	defect,to
R3470	T11597	T11596	amod	true,defect
R3471	T11598	T11596	compound	differentiation,defect
R3472	T11599	T11592	prep	in,relate
R3473	T11600	T11601	det	a,subset
R3474	T11601	T11599	pobj	subset,in
R3475	T11602	T11601	prep	of,subset
R3476	T11603	T11604	amod	amacrine,cells
R3477	T11604	T11602	pobj	cells,of
R3478	T11605	T11601	acl	discussed,subset
R3479	T11606	T11605	advmod	below,discussed
R3480	T11607	T11592	punct	.,relate
R3481	T11609	T11610	det	This,discussion
R3482	T11610	T11611	nsubj	discussion,obscure
R3483	T11612	T11611	aux	should,obscure
R3484	T11613	T11611	neg	not,obscure
R3485	T11614	T11615	det	the,outcome
R3486	T11615	T11611	dobj	outcome,obscure
R3487	T11616	T11615	amod	major,outcome
R3488	T11617	T11618	mark	that,recovers
R3489	T11618	T11615	acl	recovers,outcome
R3490	T11619	T11620	compound	E2f1,deletion
R3491	T11620	T11618	nsubj	deletion,recovers
R3492	T11621	T11618	dobj	most,recovers
R3493	T11622	T11621	prep	of,most
R3494	T11623	T11624	det	the,response
R3495	T11624	T11622	pobj	response,of
R3496	T11625	T11624	compound	ERG,response
R3497	T11626	T11611	punct	.,obscure
R3498	T11628	T11629	advmod	Thus,deletion
R3499	T11630	T11629	punct	", ",deletion
R3500	T11631	T11629	compound	E2f1,deletion
R3501	T11632	T11629	preconj	not,deletion
R3502	T11633	T11632	advmod	only,not
R3503	T11634	T11629	conj	rescues,deletion
R3504	T11635	T11634	dobj	morphology,rescues
R3505	T11636	T11635	cc	but,morphology
R3506	T11637	T11636	advmod	also,but
R3507	T11638	T11639	preconj	both,rod
R3508	T11639	T11640	nmod	rod,function
R3509	T11640	T11635	conj	function,morphology
R3510	T11641	T11639	cc	and,rod
R3511	T11642	T11639	conj	cone,rod
R3512	T11643	T11640	compound	system,function
R3513	T11644	T11634	prep	in,rescues
R3514	T11645	T11646	det	the,retina
R3515	T11646	T11644	pobj	retina,in
R3516	T11647	T11648	compound	Rb,KO
R3517	T11648	T11646	compound	KO,retina
R3518	T11649	T11634	punct	.,rescues
R3525	T13755	T13756	amod	Abnormal,Differentiation
R3526	T13757	T13756	compound	SAC,Differentiation
R3527	T13758	T13756	amod	Independent,Differentiation
R3528	T13759	T13758	prep	of,Independent
R3529	T13760	T13761	compound	Cell,Cycle
R3530	T13761	T13759	pobj	Cycle,of
R3531	T13762	T13761	cc	and,Cycle
R3532	T13763	T13764	compound	Survival,Defects
R3533	T13764	T13761	conj	Defects,Cycle
R3534	T13766	T13767	nsubj	ERGs,assess
R3535	T13768	T13767	advmod	primarily,assess
R3536	T13769	T13770	nmod	photoreceptor,function
R3537	T13770	T13767	dobj	function,assess
R3538	T13771	T13769	cc	and,photoreceptor
R3539	T13772	T13773	amod	bipolar,cell
R3540	T13773	T13769	conj	cell,photoreceptor
R3541	T13774	T13767	punct	", ",assess
R3542	T13775	T13767	cc	but,assess
R3543	T13776	T13777	aux	may,miss
R3544	T13777	T13767	conj	miss,assess
R3545	T13778	T13779	compound	differentiation,defects
R3546	T13779	T13777	dobj	defects,miss
R3547	T13780	T13777	prep	in,miss
R3548	T13781	T13782	amod	other,cells
R3549	T13782	T13780	pobj	cells,in
R3550	T13783	T13767	punct	.,assess
R3551	T13785	T13786	aux	To,test
R3552	T13786	T13787	advcl	test,stained
R3553	T13788	T13786	prep	for,test
R3554	T13789	T13790	amod	subtle,differences
R3555	T13790	T13788	pobj	differences,for
R3556	T13791	T13787	nsubj	we,stained
R3557	T13792	T13793	det	the,retina
R3558	T13793	T13787	dobj	retina,stained
R3559	T13794	T13795	compound	Rb,E2f1
R3560	T13795	T13797	compound	E2f1,DKO
R3561	T13796	T13795	punct	/,E2f1
R3562	T13797	T13793	compound	DKO,retina
R3563	T13798	T13787	prep	with,stained
R3564	T13799	T13800	nummod	43,markers
R3565	T13800	T13798	pobj	markers,with
R3566	T13801	T13802	punct	(,S1
R3567	T13802	T13787	parataxis	S1,stained
R3568	T13803	T13802	compound	Table,S1
R3569	T13804	T13802	punct	),S1
R3570	T13805	T13787	punct	.,stained
R3571	T13807	T13808	compound	Thirty,two
R3572	T13808	T13810	nummod	two,proteins
R3573	T13809	T13808	punct	-,two
R3574	T13810	T13811	nsubj	proteins,displayed
R3575	T13812	T13813	amod	identical,patterns
R3576	T13813	T13811	dobj	patterns,displayed
R3577	T13814	T13811	prep	in,displayed
R3578	T13815	T13816	nmod	WT,retina
R3579	T13816	T13814	pobj	retina,in
R3580	T13817	T13815	punct	", ",WT
R3581	T13818	T13819	compound	E2f1,KO
R3582	T13819	T13815	conj	KO,WT
R3583	T13820	T13819	punct	", ",KO
R3584	T13821	T13819	cc	and,KO
R3585	T13822	T13823	compound	Rb,E2f1
R3586	T13823	T13825	compound	E2f1,DKO
R3587	T13824	T13823	punct	/,E2f1
R3588	T13825	T13819	conj	DKO,KO
R3589	T13826	T13827	punct	(,S1
R3590	T13827	T13811	parataxis	S1,displayed
R3591	T13828	T13827	compound	Table,S1
R3592	T13829	T13827	punct	),S1
R3593	T13830	T13811	punct	.,displayed
R3594	T13832	T13833	det	The,markers
R3595	T13833	T13836	nsubj	markers,revealed
R3596	T13834	T13833	amod	other,markers
R3597	T13835	T13833	nummod	11,markers
R3598	T13837	T13838	det	a,defect
R3599	T13838	T13836	dobj	defect,revealed
R3600	T13839	T13840	compound	cell,cycle
R3601	T13840	T13842	npadvmod	cycle,independent
R3602	T13841	T13840	punct	-,cycle
R3603	T13842	T13838	amod	independent,defect
R3604	T13843	T13840	punct	–,cycle
R3605	T13844	T13840	cc	and,cycle
R3606	T13845	T13840	conj	apoptosis,cycle
R3607	T13846	T13842	punct	-,independent
R3608	T13847	T13838	compound	differentiation,defect
R3609	T13848	T13836	prep	in,revealed
R3610	T13849	T13848	pobj	SACs,in
R3611	T13850	T13836	punct	.,revealed
R3612	T13852	T13853	nsubj	We,studied
R3613	T13854	T13853	advmod	first,studied
R3614	T13855	T13853	dobj	Calb2,studied
R3615	T13856	T13855	punct	(,Calb2
R3616	T13857	T13855	appos	calretinin,Calb2
R3617	T13858	T13855	punct	),Calb2
R3618	T13859	T13855	punct	", ",Calb2
R3619	T13860	T13861	dep	which,marks
R3620	T13861	T13855	relcl	marks,Calb2
R3621	T13862	T13863	det	a,subset
R3622	T13863	T13861	dobj	subset,marks
R3623	T13864	T13863	prep	of,subset
R3624	T13865	T13866	amod	amacrine,bodies
R3625	T13866	T13864	pobj	bodies,of
R3626	T13867	T13865	cc	and,amacrine
R3627	T13868	T13869	compound	ganglion,cell
R3628	T13869	T13865	conj	cell,amacrine
R3629	T13870	T13871	advmod	as,as
R3630	T13871	T13863	cc	as,subset
R3631	T13872	T13871	advmod	well,as
R3632	T13873	T13874	nummod	three,tracks
R3633	T13874	T13863	conj	tracks,subset
R3634	T13875	T13874	acl	corresponding,tracks
R3635	T13876	T13875	prep	to,corresponding
R3636	T13877	T13878	poss	their,processes
R3637	T13878	T13876	pobj	processes,to
R3638	T13879	T13878	prep	in,processes
R3639	T13880	T13881	det	the,IPL
R3640	T13881	T13879	pobj	IPL,in
R3641	T13882	T13883	punct	(,3A
R3642	T13883	T13861	parataxis	3A,marks
R3643	T13884	T13883	compound	Figure,3A
R3644	T13885	T13883	punct	),3A
R3645	T13886	T13853	punct	.,studied
R3646	T13888	T13889	amod	Normal,staining
R3647	T13889	T13891	nsubjpass	staining,seen
R3648	T13890	T13889	compound	Calb2,staining
R3649	T13892	T13891	auxpass	was,seen
R3650	T13893	T13891	prep	in,seen
R3651	T13894	T13895	det	the,IPL
R3652	T13895	T13893	pobj	IPL,in
R3653	T13896	T13897	compound	E2f1,KO
R3654	T13897	T13895	compound	KO,IPL
R3655	T13898	T13899	punct	(,shown
R3656	T13899	T13891	parataxis	shown,seen
R3657	T13900	T13899	nsubj	data,shown
R3658	T13901	T13899	neg	not,shown
R3659	T13902	T13899	punct	),shown
R3660	T13903	T13891	punct	.,seen
R3661	T13905	T13906	advmod	However,was
R3662	T13907	T13906	punct	", ",was
R3663	T13908	T13909	advmod	only,track
R3664	T13909	T13906	nsubj	track,was
R3665	T13910	T13909	nummod	one,track
R3666	T13911	T13909	nmod	Calb2,track
R3667	T13912	T13911	punct	+,Calb2
R3668	T13913	T13906	acomp	evident,was
R3669	T13914	T13906	prep	in,was
R3670	T13915	T13916	det	the,IPL
R3672	T13917	T13918	compound	Rb,KO
R3697	T13944	T13942	compound	cell,bodies
R3698	T13945	T13940	prep	in,quantified
R3699	T13946	T13947	det	the,INL
R3700	T13947	T13945	pobj	INL,in
R3701	T13948	T13949	compound	Rb,KO
R3702	T13949	T13947	compound	KO,INL
R3703	T13950	T13947	punct	(,INL
R3704	T13951	T13947	acl	corresponding,INL
R3705	T13952	T13951	prep	to,corresponding
R3706	T13953	T13954	amod	amacrine,cell
R3707	T13954	T13955	compound	cell,staining
R3708	T13955	T13952	pobj	staining,to
R3709	T13956	T13955	advmod	only,staining
R3710	T13957	T13940	punct	),quantified
R3711	T13958	T13940	cc	and,quantified
R3712	T13959	T13940	conj	observed,quantified
R3713	T13960	T13961	det	a,reduction
R3714	T13961	T13959	dobj	reduction,observed
R3715	T13962	T13959	prep	from,observed
R3716	T13963	T13962	pobj	P8,from
R3717	T13964	T13963	advmod	onwards,P8
R3718	T13965	T13966	punct	(,3C
R3719	T13966	T13959	parataxis	3C,observed
R3720	T13967	T13966	compound	Figures,3C
R3721	T13968	T13966	cc	and,3C
R3722	T13969	T13966	conj	S6,3C
R3723	T13970	T13966	punct	),3C
R3724	T13971	T13940	punct	.,quantified
R3725	T13977	T13976	pobj	t,f
R3742	T14015	T14013	pobj	morphology,after
R3743	T14016	T14015	amod	extensive,morphology
R3744	T14017	T14018	amod	dendritic,tree
R3745	T14018	T14020	npadvmod	tree,like
R3746	T14019	T14018	punct	-,tree
R3747	T14020	T14015	amod	like,morphology
R3748	T14021	T14020	punct	-,like
R3749	T14022	T14023	punct	[,37
R3750	T14023	T14001	parataxis	37,are
R3751	T14024	T14023	punct	],37
R3752	T14025	T14001	punct	.,are
R3753	T14027	T14028	nsubj	SACs,are
R3754	T14029	T14028	acomp	cholinergic,are
R3755	T14030	T14028	punct	", ",are
R3756	T14031	T14028	conj	represent,are
R3757	T14032	T14033	punct	~,5.2
R3758	T14033	T14034	nummod	5.2,%
R3759	T14034	T14031	dobj	%,represent
R3760	T14035	T14034	prep	of,%
R3761	T14036	T14037	amod	amacrine,neurons
R3762	T14037	T14035	pobj	neurons,of
R3763	T14038	T14039	punct	[,38
R3764	T14039	T14031	parataxis	38,represent
R3765	T14040	T14039	punct	],38
R3766	T14041	T14031	punct	", ",represent
R3767	T14042	T14031	cc	and,represent
R3768	T14043	T14031	conj	are,represent
R3769	T14044	T14043	acomp	critical,are
R3770	T14045	T14044	prep	for,critical
R3771	T14046	T14047	preconj	both,selectivity
R3772	T14047	T14045	pobj	selectivity,for
R3773	T14048	T14047	compound	direction,selectivity
R3774	T14049	T14050	punct	[,35
R3775	T14050	T14047	parataxis	35,selectivity
R3776	T14051	T14050	nummod	34,35
R3777	T14052	T14050	punct	",",35
R3778	T14053	T14050	punct	],35
R3779	T14054	T14047	cc	and,selectivity
R3780	T14055	T14056	amod	spontaneous,activity
R3781	T14056	T14047	conj	activity,selectivity
R3782	T14057	T14056	amod	rhythmic,activity
R3783	T14058	T14059	dep	that,occurs
R3784	T14059	T14056	relcl	occurs,activity
R3785	T14060	T14059	prep	during,occurs
R3786	T14061	T14062	amod	normal,development
R3787	T14062	T14060	pobj	development,during
R3788	T14063	T14062	amod	retinal,development
R3789	T14064	T14065	punct	[,36
R3790	T14065	T14056	parataxis	36,activity
R3791	T14066	T14065	punct	],36
R3792	T14067	T14028	punct	.,are
R3793	T14069	T14070	nsubj	SACs,synapse
R3794	T14071	T14069	prep	in,SACs
R3795	T14072	T14073	det	the,INL
R3796	T14073	T14071	pobj	INL,in
R3797	T14074	T14070	prep	in,synapse
R3798	T14075	T14076	det	the,layer
R3799	T14076	T14074	pobj	layer,in
R3800	T14077	T14076	compound	OFF,layer
R3801	T14078	T14076	prep	of,layer
R3802	T14079	T14080	det	the,IPL
R3803	T14080	T14078	pobj	IPL,of
R3804	T14081	T14082	dep	that,responds
R3805	T14082	T14076	relcl	responds,layer
R3806	T14083	T14082	prep	to,responds
R3807	T14084	T14085	amod	decreasing,light
R3808	T14085	T14083	pobj	light,to
R3809	T14086	T14070	punct	", ",synapse
R3810	T14087	T14088	mark	while,have
R3811	T14088	T14070	advcl	have,synapse
R3812	T14089	T14090	amod	displaced,SACs
R3813	T14090	T14088	nsubj	SACs,have
R3814	T14091	T14090	prep	in,SACs
R3815	T14092	T14093	det	the,GCL
R3816	T14093	T14091	pobj	GCL,in
R3817	T14094	T14088	dobj	processes,have
R3818	T14095	T14096	dep	that,synapse
R3819	T14096	T14094	relcl	synapse,processes
R3820	T14097	T14096	prep	in,synapse
R3821	T14098	T14099	det	the,layer
R3822	T14099	T14097	pobj	layer,in
R3823	T14100	T14099	amod	nearby,layer
R3824	T14101	T14099	compound	ON,layer
R3825	T14102	T14099	prep	of,layer
R3826	T14103	T14104	det	the,IPL
R3827	T14104	T14102	pobj	IPL,of
R3828	T14105	T14106	dep	that,responds
R3829	T14106	T14099	relcl	responds,layer
R3830	T14107	T14106	prep	to,responds
R3831	T14108	T14109	amod	increasing,light
R3832	T14109	T14107	pobj	light,to
R3833	T14110	T14111	punct	(,reviewed
R3834	T14111	T14088	parataxis	reviewed,have
R3835	T14112	T14111	prep	in,reviewed
R3836	T14113	T14112	punct	[,in
R3837	T14114	T14112	pobj	39,in
R3838	T14115	T14111	punct	],reviewed
R3839	T14116	T14111	punct	),reviewed
R3840	T14117	T14070	punct	.,synapse
R3841	T14119	T14120	amod	Mature,processes
R3842	T14120	T14122	nsubj	processes,stain
R3843	T14121	T14120	compound	SAC,processes
R3844	T14123	T14124	advmod	specifically,for
R3845	T14124	T14122	prep	for,stain
R3846	T14125	T14124	pobj	Slc18a3,for
R3847	T14126	T14125	punct	(,Slc18a3
R3848	T14127	T14128	amod	vesicular,transporter
R3849	T14128	T14125	appos	transporter,Slc18a3
R3850	T14129	T14128	compound	acetyl,transporter
R3851	T14130	T14128	compound	choline,transporter
R3852	T14131	T14128	punct	", ",transporter
R3853	T14132	T14128	appos	VAChT,transporter
R3854	T14133	T14122	punct	),stain
R3855	T14134	T14135	punct	[,37
R3856	T14135	T14122	parataxis	37,stain
R3857	T14136	T14135	punct	],37
R3858	T14137	T14122	punct	", ",stain
R3859	T14138	T14122	cc	and,stain
R3860	T14139	T14122	punct	", ",stain
R3861	T14140	T14141	advmod	significantly,was
R3862	T14141	T14122	conj	was,stain
R3863	T14142	T14141	punct	", ",was
R3864	T14143	T14144	det	this,marker
R3865	T14144	T14141	nsubj	marker,was
R3866	T14145	T14141	acomp	absent,was
R3867	T14146	T14141	prep	in,was
R3868	T14147	T14148	det	the,retina
R3869	T14148	T14146	pobj	retina,in
R3870	T14149	T14148	amod	peripheral,retina
R3871	T14150	T14151	nmod	Rb,KO
R3872	T14151	T14148	nmod	KO,retina
R3873	T14152	T14151	cc	or,KO
R3874	T14153	T14154	compound	Rb,E2f1
R3875	T14154	T14156	compound	E2f1,DKO
R3876	T14155	T14154	punct	/,E2f1
R3877	T14156	T14151	conj	DKO,KO
R3878	T14157	T14148	compound	P18,retina
R3879	T14158	T14159	punct	(,3A
R3880	T14159	T14141	parataxis	3A,was
R3881	T14160	T14159	compound	Figures,3A
R3882	T14161	T14159	cc	and,3A
R3883	T14162	T14159	conj	S7B,3A
R3884	T14163	T14159	punct	),3A
R3885	T14164	T14141	punct	.,was
R3886	T14166	T14167	nsubj	Chat,is
R3887	T14168	T14166	punct	", ",Chat
R3888	T14169	T14166	acl	expressed,Chat
R3889	T14170	T14169	prep	from,expressed
R3890	T14171	T14172	det	the,locus
R3891	T14172	T14170	pobj	locus,from
R3892	T14173	T14172	amod	same,locus
R3893	T14174	T14167	punct	", ",is
R3894	T14175	T14167	advmod	also,is
R3895	T14176	T14177	npadvmod	SAC,specific
R3896	T14177	T14167	acomp	specific,is
R3897	T14178	T14167	punct	", ",is
R3898	T14179	T14167	cc	but,is
R3899	T14180	T14167	conj	marks,is
R3900	T14181	T14182	preconj	both,bodies
R3901	T14182	T14180	dobj	bodies,marks
R3902	T14183	T14182	compound	cell,bodies
R3903	T14184	T14182	cc	and,bodies
R3904	T14185	T14182	conj	processes,bodies
R3905	T14186	T14182	prep	of,bodies
R3906	T14187	T14188	amod	mature,SACs
R3907	T14188	T14186	pobj	SACs,of
R3908	T14189	T14190	punct	[,37
R3909	T14190	T14180	parataxis	37,marks
R3910	T14191	T14190	punct	],37
R3911	T14192	T14167	punct	.,is
R3912	T14194	T14195	nsubjpass	Chat,seen
R3913	T14196	T14195	auxpass	was,seen
R3914	T14197	T14195	prep	in,seen
R3915	T14198	T14199	amod	fewer,cells
R3916	T14199	T14197	pobj	cells,in
R3917	T14200	T14199	prep	in,cells
R3918	T14201	T14202	det	the,retina
R3919	T14202	T14200	pobj	retina,in
R3920	T14203	T14202	amod	mature,retina
R3921	T14204	T14205	compound	Rb,KO
R3922	T14205	T14202	compound	KO,retina
R3923	T14206	T14195	punct	", ",seen
R3924	T14207	T14195	cc	and,seen
R3925	T14208	T14195	conj	was,seen
R3926	T14209	T14208	acomp	present,was
R3927	T14210	T14208	prep	in,was
R3928	T14211	T14212	det	the,soma
R3929	T14212	T14210	pobj	soma,in
R3930	T14213	T14208	cc	but,was
R3931	T14214	T14208	conj	absent,was
R3932	T14215	T14214	prep	from,absent
R3933	T14216	T14215	pobj	processes,from
R3934	T14217	T14218	punct	(,3B
R3935	T14218	T14208	parataxis	3B,was
R3936	T14219	T14218	compound	Figure,3B
R3937	T14220	T14218	punct	),3B
R3938	T14221	T14195	punct	.,seen
R3939	T14223	T14224	nsubj	We,obtained
R3940	T14225	T14226	amod	similar,results
R3941	T14226	T14224	dobj	results,obtained
R3942	T14227	T14224	prep	for,obtained
R3943	T14228	T14227	pobj	Sv2c,for
R3944	T14229	T14228	punct	", ",Sv2c
R3945	T14230	T14231	det	a,protein
R3946	T14231	T14228	appos	protein,Sv2c
R3947	T14232	T14233	amod	synaptic,vesicle
R3948	T14233	T14231	compound	vesicle,protein
R3949	T14234	T14231	acl	found,protein
R3950	T14235	T14234	prep	in,found
R3951	T14236	T14235	pobj	SACs,in
R3952	T14237	T14238	punct	[,40
R3953	T14238	T14234	parataxis	40,found
R3954	T14239	T14238	punct	],40
R3955	T14240	T14228	punct	;,Sv2c
R3956	T14241	T14228	conj	Kcnc1b,Sv2c
R3957	T14242	T14241	cc	and,Kcnc1b
R3958	T14243	T14241	conj	Kcnc2,Kcnc1b
R3959	T14244	T14241	punct	", ",Kcnc1b
R3960	T14245	T14246	compound	potassium,channels
R3961	T14246	T14241	appos	channels,Kcnc1b
R3962	T14247	T14246	acl	expressed,channels
R3963	T14248	T14247	prep	on,expressed
R3964	T14249	T14250	compound	SAC,soma
R3965	T14250	T14248	pobj	soma,on
R3966	T14251	T14250	cc	and,soma
R3967	T14252	T14250	conj	dendrites,soma
R3968	T14253	T14254	advmod	as,as
R3969	T14254	T14250	cc	as,soma
R3970	T14255	T14254	advmod	well,as
R3971	T14256	T14257	det	a,number
R3972	T14257	T14250	conj	number,soma
R3973	T14258	T14259	advmod	very,small
R3974	T14259	T14257	amod	small,number
R3975	T14260	T14257	prep	of,number
R3976	T14261	T14262	compound	ganglion,cells
R3977	T14262	T14260	pobj	cells,of
R3978	T14263	T14264	punct	[,41
R3979	T14264	T14247	parataxis	41,expressed
R3980	T14265	T14264	punct	],41
R3981	T14266	T14241	punct	;,Kcnc1b
R3982	T14267	T14268	nmod	gamma,acid
R3983	T14268	T14241	conj	acid,Kcnc1b
R3984	T14269	T14268	punct	-,acid
R3985	T14270	T14268	amod	aminobutyric,acid
R3986	T14271	T14268	punct	(,acid
R3987	T14272	T14268	appos	GABA,acid
R3988	T14273	T14268	punct	),acid
R3989	T14274	T14268	punct	", ",acid
R3990	T14275	T14276	det	an,neurotransmitter
R3991	T14276	T14268	appos	neurotransmitter,acid
R3992	T14277	T14276	amod	inhibitory,neurotransmitter
R3993	T14278	T14276	relcl	present,neurotransmitter
R3994	T14279	T14278	prep	in,present
R3995	T14280	T14281	quantmod	about,half
R3996	T14281	T14279	pobj	half,in
R3997	T14282	T14281	prep	of,half
R3998	T14283	T14284	amod	amacrine,cells
R3999	T14284	T14282	pobj	cells,of
R4000	T14285	T14281	prep	including,half
R4001	T14286	T14285	pobj	SACs,including
R4002	T14287	T14281	punct	", ",half
R4003	T14288	T14289	advmod	as,as
R4004	T14289	T14281	cc	as,half
R4005	T14290	T14289	advmod	well,as
R4006	T14291	T14281	conj	horizontal,half
R4007	T14292	T14291	cc	and,horizontal
R4008	T14293	T14294	det	some,bipolar
R4009	T14294	T14295	nmod	bipolar,neurons
R4010	T14295	T14291	conj	neurons,horizontal
R4011	T14296	T14297	punct	[,37
R4012	T14297	T14278	parataxis	37,present
R4013	T14298	T14297	punct	],37
R4014	T14299	T14268	punct	;,acid
R4015	T14300	T14268	cc	and,acid
R4016	T14301	T14268	conj	Calb1,acid
R4017	T14302	T14301	punct	(,Calb1
R4018	T14303	T14301	appos	calbindin,Calb1
R4019	T14304	T14301	punct	),Calb1
R4020	T14305	T14301	punct	", ",Calb1
R4021	T14306	T14307	dep	which,expressed
R4022	T14307	T14301	relcl	expressed,Calb1
R4023	T14308	T14307	auxpass	is,expressed
R4024	T14309	T14307	prep	in,expressed
R4025	T14310	T14311	amod	many,cells
R4026	T14311	T14309	pobj	cells,in
R4027	T14312	T14311	amod	amacrine,cells
R4028	T14313	T14307	cc	and,expressed
R4029	T14314	T14307	conj	labels,expressed
R4030	T14315	T14316	compound	SAC,process
R4031	T14316	T14314	dobj	process,labels
R4032	T14317	T14314	advmod	faintly,labels
R4033	T14318	T14319	punct	(,S7A
R4034	T14319	T14314	parataxis	S7A,labels
R4035	T14320	T14319	compound	Figure,S7A
R4036	T14321	T14319	cc	and,S7A
R4037	T14322	T14319	conj	S7B,S7A
R4038	T14323	T14319	punct	;,S7A
R4039	T14324	T14325	compound	Table,S1
R4040	T14325	T14319	conj	S1,S7A
R4041	T14326	T14325	punct	;,S1
R4042	T14327	T14325	cc	and,S1
R4043	T14328	T14329	nsubj	data,shown
R4044	T14329	T14325	conj	shown,S1
R4045	T14330	T14329	neg	not,shown
R4046	T14331	T14329	punct	),shown
R4047	T14332	T14224	punct	.,obtained
R4048	T14334	T14335	advmod	Finally,examined
R4049	T14336	T14335	punct	", ",examined
R4050	T14337	T14335	nsubj	we,examined
R4051	T14338	T14335	advmod	also,examined
R4052	T14339	T14340	det	the,effect
R4053	T14340	T14335	dobj	effect,examined
R4054	T14341	T14340	prep	of,effect
R4055	T14342	T14343	compound	Rb,deletion
R4056	T14343	T14341	pobj	deletion,of
R4057	T14344	T14340	prep	on,effect
R4058	T14345	T14346	compound	SAC,differentiation
R4059	T14346	T14344	pobj	differentiation,on
R4060	T14347	T14335	advcl	using,examined
R4061	T14348	T14349	det	a,transgene
R4062	T14349	T14347	dobj	transgene,using
R4063	T14350	T14351	compound	Chx10,Cre
R4064	T14351	T14349	compound	Cre,transgene
R4065	T14352	T14351	punct	-,Cre
R4066	T14353	T14354	dep	that,expressed
R4067	T14354	T14349	relcl	expressed,transgene
R4068	T14355	T14354	auxpass	is,expressed
R4069	T14356	T14354	prep	in,expressed
R4070	T14357	T14358	det	a,pattern
R4071	T14358	T14356	pobj	pattern,in
R4072	T14359	T14358	amod	mosaic,pattern
R4073	T14360	T14354	prep	across,expressed
R4074	T14361	T14362	det	the,retina
R4075	T14362	T14360	pobj	retina,across
R4076	T14363	T14354	punct	", ",expressed
R4077	T14364	T14354	advcl	generating,expressed
R4078	T14365	T14364	dobj	patches,generating
R4079	T14366	T14365	prep	of,patches
R4080	T14367	T14368	npadvmod	Cre,expressing
R4081	T14368	T14370	amod	expressing,cells
R4082	T14369	T14368	punct	-,expressing
R4083	T14370	T14366	pobj	cells,of
R4084	T14371	T14372	punct	[,42
R4085	T14372	T14364	parataxis	42,generating
R4086	T14373	T14372	punct	],42
R4087	T14374	T14335	punct	.,examined
R4088	T14376	T14377	advcl	Consistent,observed
R4089	T14378	T14376	prep	with,Consistent
R4090	T14379	T14380	det	the,pattern
R4091	T14380	T14378	pobj	pattern,with
R4092	T14381	T14382	amod	mosaic,deletion
R4093	T14382	T14380	compound	deletion,pattern
R4094	T14383	T14377	punct	", ",observed
R4095	T14384	T14377	nsubj	we,observed
R4096	T14385	T14386	advmod	markedly,reduced
R4097	T14386	T14387	amod	reduced,staining
R4098	T14387	T14377	dobj	staining,observed
R4099	T14388	T14389	compound	Chat,Slc18a3
R4100	T14389	T14387	compound	Slc18a3,staining
R4101	T14390	T14389	punct	/,Slc18a3
R4102	T14391	T14377	prep	in,observed
R4103	T14392	T14393	det	the,IPL
R4104	T14393	T14391	pobj	IPL,in
R4105	T14394	T14393	prep	of,IPL
R4106	T14395	T14396	nmod	Chx10,Cre
R4107	T14396	T14398	nmod	Cre,retina
R4108	T14397	T14396	punct	-,Cre
R4109	T14398	T14394	pobj	retina,of
R4110	T14399	T14396	punct	;,Cre
R4111	T14400	T14401	compound	RbloxP,loxP
R4112	T14401	T14396	appos	loxP,Cre
R4113	T14402	T14401	punct	/,loxP
R4114	T14403	T14377	prep	compared,observed
R4115	T14404	T14403	prep	to,compared
R4116	T14405	T14404	pobj	WT,to
R4117	T14406	T14407	punct	(,S7C
R4118	T14407	T14377	parataxis	S7C,observed
R4119	T14408	T14407	compound	Figure,S7C
R4120	T14409	T14407	punct	),S7C
R4121	T14410	T14377	punct	.,observed
R4122	T14412	T14413	advmod	Together,suggest
R4123	T14414	T14413	punct	", ",suggest
R4124	T14415	T14416	det	these,results
R4125	T14416	T14413	nsubj	results,suggest
R4126	T14417	T14418	det	a,role
R4127	T14418	T14413	dobj	role,suggest
R4128	T14419	T14418	prep	for,role
R4129	T14420	T14419	pobj	Rb,for
R4130	T14421	T14418	prep	in,role
R4131	T14422	T14423	compound	SAC,differentiation
R4132	T14423	T14421	pobj	differentiation,in
R4133	T14424	T14413	punct	.,suggest
R4134	T14426	T14427	det	The,findings
R4135	T14427	T14429	nsubj	findings,indicate
R4136	T14428	T14427	amod	above,findings
R4137	T14430	T14429	aux	could,indicate
R4138	T14431	T14432	det	a,defect
R4139	T14432	T14429	dobj	defect,indicate
R4140	T14433	T14432	prep	in,defect
R4141	T14434	T14435	compound	SAC,specification
R4142	T14435	T14433	pobj	specification,in
R4143	T14436	T14435	punct	", ",specification
R4144	T14437	T14438	compound	SAC,survival
R4145	T14438	T14435	conj	survival,specification
R4146	T14439	T14438	punct	", ",survival
R4147	T14440	T14438	cc	or,survival
R4148	T14441	T14442	det	the,levels
R4149	T14442	T14438	conj	levels,survival
R4150	T14443	T14442	cc	and,levels
R4151	T14444	T14443	punct	/,and
R4152	T14445	T14443	cc	or,and
R4153	T14446	T14442	conj	transport,levels
R4154	T14447	T14442	prep	of,levels
R4155	T14448	T14449	det	the,markers
R4156	T14449	T14447	pobj	markers,of
R4157	T14450	T14449	acl	described,markers
R4158	T14451	T14450	advmod	above,described
R4159	T14452	T14429	punct	.,indicate
R4160	T14454	T14455	nsubj	Camk2a,marks
R4161	T14456	T14457	preconj	both,SACs
R4162	T14457	T14455	dobj	SACs,marks
R4163	T14458	T14457	cc	and,SACs
R4164	T14459	T14460	compound	ganglion,cells
R4165	T14460	T14457	conj	cells,SACs
R4166	T14461	T14462	punct	[,37
R4167	T14462	T14455	parataxis	37,marks
R4168	T14463	T14462	punct	],37
R4169	T14464	T14455	punct	", ",marks
R4170	T14465	T14455	cc	but,marks
R4171	T14466	T14467	mark	because,eliminated
R4172	T14467	T14471	advcl	eliminated,is
R4173	T14468	T14469	compound	ganglion,cells
R4174	T14469	T14467	nsubjpass	cells,eliminated
R4175	T14470	T14467	auxpass	are,eliminated
R4176	T14471	T14455	conj	is,marks
R4177	T14472	T14467	prep	in,eliminated
R4178	T14473	T14474	det	the,retina
R4179	T14474	T14472	pobj	retina,in
R4180	T14475	T14476	compound	Rb,KO
R4181	T14476	T14474	compound	KO,retina
R4182	T14477	T14471	punct	", ",is
R4183	T14478	T14471	nsubj	Camk2a,is
R4184	T14479	T14480	det	a,marker
R4185	T14480	T14471	attr	marker,is
R4186	T14481	T14480	amod	specific,marker
R4187	T14482	T14480	compound	SAC,marker
R4188	T14483	T14471	prep	in,is
R4189	T14484	T14485	det	this,context
R4190	T14485	T14483	pobj	context,in
R4191	T14486	T14471	punct	.,is
R4192	T14488	T14489	advmod	Importantly,were
R4193	T14490	T14489	punct	", ",were
R4194	T14491	T14489	nsubj	Camk2a,were
R4195	T14492	T14491	punct	+,Camk2a
R4196	T14493	T14491	appos	tracks,Camk2a
R4197	T14494	T14493	cc	and,tracks
R4198	T14495	T14493	conj	dendrites,tracks
R4199	T14496	T14489	acomp	present,were
R4200	T14497	T14489	prep	in,were
R4201	T14498	T14499	preconj	both,retina
R4202	T14499	T14497	pobj	retina,in
R4203	T14500	T14499	det	the,retina
R4204	T14501	T14499	nmod	WT,retina
R4205	T14502	T14501	cc	and,WT
R4206	T14503	T14504	compound	Rb,KO
R4207	T14504	T14501	conj	KO,WT
R4208	T14505	T14506	punct	(,3B
R4209	T14506	T14489	parataxis	3B,were
R4210	T14507	T14506	compound	Figure,3B
R4211	T14508	T14506	punct	),3B
R4212	T14509	T14489	punct	", ",were
R4213	T14510	T14489	cc	and,were
R4214	T14511	T14512	det	the,number
R4215	T14512	T14513	nsubj	number,was
R4216	T14513	T14489	conj	was,were
R4217	T14514	T14512	prep	of,number
R4218	T14515	T14516	nmod	Camk2a,soma
R4219	T14516	T14514	pobj	soma,of
R4220	T14517	T14515	punct	+,Camk2a
R4221	T14518	T14513	acomp	similar,was
R4222	T14519	T14513	prep	in,was
R4223	T14520	T14521	nmod	WT,retina
R4224	T14521	T14519	pobj	retina,in
R4225	T14522	T14520	cc	and,WT
R4226	T14523	T14524	compound	Rb,KO
R4227	T14524	T14520	conj	KO,WT
R4228	T14525	T14513	prep	at,was
R4229	T14526	T14525	pobj	P30,at
R4230	T14527	T14526	cc	and,P30
R4231	T14528	T14526	conj	beyond,P30
R4232	T14529	T14513	punct	", ",was
R4233	T14530	T14531	mark	although,stained
R4234	T14531	T14513	advcl	stained,was
R4235	T14532	T14533	amod	fewer,cells
R4236	T14533	T14531	nsubj	cells,stained
R4237	T14534	T14531	prep	in,stained
R4238	T14535	T14536	compound	Rb,KO
R4239	T14536	T14537	compound	KO,retina
R4240	T14537	T14534	pobj	retina,in
R4241	T14538	T14531	prep	at,stained
R4242	T14539	T14538	pobj	P18,at
R4243	T14540	T14531	punct	", ",stained
R4244	T14541	T14531	advcl	suggesting,stained
R4245	T14542	T14543	det	a,delay
R4246	T14543	T14541	dobj	delay,suggesting
R4247	T14544	T14543	prep	in,delay
R4248	T14545	T14546	poss	its,appearance
R4249	T14546	T14544	pobj	appearance,in
R4250	T14547	T14548	punct	(,3C
R4251	T14548	T14541	parataxis	3C,suggesting
R4252	T14549	T14548	compound	Figures,3C
R4253	T14550	T14548	cc	and,3C
R4254	T14551	T14548	conj	S6B,3C
R4255	T14552	T14548	punct	),3C
R4256	T14553	T14513	punct	.,was
R4257	T14555	T14556	advmod	Thus,required
R4258	T14557	T14556	punct	", ",required
R4259	T14558	T14556	nsubjpass	Rb,required
R4260	T14559	T14556	auxpass	is,required
R4261	T14560	T14556	neg	not,required
R4262	T14561	T14556	prep	for,required
R4263	T14562	T14563	compound	SAC,survival
R4264	T14563	T14561	pobj	survival,for
R4265	T14564	T14561	cc	or,for
R4266	T14565	T14561	conj	for,for
R4267	T14566	T14567	compound	process,outgrowth
R4268	T14567	T14565	pobj	outgrowth,for
R4269	T14568	T14556	punct	", ",required
R4270	T14569	T14556	cc	but,required
R4271	T14570	T14569	advmod	rather,but
R4272	T14571	T14572	nsubj	it,seems
R4273	T14572	T14556	conj	seems,required
R4274	T14573	T14574	aux	to,regulate
R4275	T14574	T14572	xcomp	regulate,seems
R4276	T14575	T14576	det	the,expression
R4277	T14576	T14574	dobj	expression,regulate
R4278	T14577	T14576	cc	and,expression
R4279	T14578	T14577	punct	/,and
R4280	T14579	T14577	cc	or,and
R4281	T14580	T14576	conj	stability,expression
R4282	T14581	T14576	prep	of,expression
R4283	T14582	T14581	pobj	Calb2,of
R4284	T14583	T14582	punct	", ",Calb2
R4285	T14584	T14582	conj	Calb1,Calb2
R4286	T14585	T14584	punct	", ",Calb1
R4287	T14586	T14584	conj	Chat,Calb1
R4288	T14587	T14586	punct	", ",Chat
R4289	T14588	T14586	conj	Slc18a3,Chat
R4290	T14589	T14588	punct	", ",Slc18a3
R4291	T14590	T14588	conj	Sv2c,Slc18a3
R4292	T14591	T14590	punct	", ",Sv2c
R4293	T14592	T14590	conj	Kcnc1b,Sv2c
R4294	T14593	T14592	punct	", ",Kcnc1b
R4295	T14594	T14592	conj	Kcnc2,Kcnc1b
R4296	T14595	T14594	punct	", ",Kcnc2
R4297	T14596	T14594	cc	and,Kcnc2
R4298	T14597	T14594	conj	GABA,Kcnc2
R4299	T14598	T14574	prep	in,regulate
R4300	T14599	T14598	pobj	SACs,in
R4301	T14600	T14572	punct	", ",seems
R4302	T14601	T14572	cc	but,seems
R4303	T14602	T14572	conj	leaves,seems
R4304	T14603	T14604	compound	Camk2a,expression
R4305	T14604	T14602	dobj	expression,leaves
R4306	T14605	T14606	advmod	virtually,unaffected
R4307	T14606	T14602	oprd	unaffected,leaves
R4308	T14607	T14572	punct	.,seems
R4309	T14609	T14610	det	The,presence
R4310	T14610	T14611	nsubj	presence,suggests
R4311	T14612	T14610	prep	of,presence
R4312	T14613	T14612	pobj	Chat,of
R4313	T14614	T14610	prep	in,presence
R4314	T14615	T14616	det	some,bodies
R4315	T14616	T14614	pobj	bodies,in
R4316	T14617	T14616	compound	cell,bodies
R4317	T14618	T14614	cc	but,in
R4318	T14619	T14620	neg	never,in
R4319	T14620	T14614	conj	in,in
R4320	T14621	T14620	pobj	processes,in
R4321	T14622	T14623	punct	(,3B
R4322	T14623	T14610	parataxis	3B,presence
R4323	T14624	T14623	compound	Figure,3B
R4324	T14625	T14623	punct	),3B
R4325	T14626	T14611	advmod	also,suggests
R4326	T14627	T14628	det	a,defect
R4327	T14628	T14611	dobj	defect,suggests
R4328	T14629	T14628	compound	transport,defect
R4329	T14630	T14611	punct	.,suggests
R4330	T14632	T14633	det	The,pattern
R4331	T14633	T14635	nsubj	pattern,supported
R4332	T14634	T14633	amod	developmental,pattern
R4333	T14636	T14633	prep	of,pattern
R4334	T14637	T14638	compound	Slc18a3,expression
R4335	T14638	T14636	pobj	expression,of
R4336	T14639	T14635	advmod	also,supported
R4337	T14640	T14641	det	this,notion
R4338	T14641	T14635	dobj	notion,supported
R4339	T14642	T14635	punct	.,supported
R4340	T14644	T14645	prep	In,is
R4341	T14646	T14647	amod	mature,SACs
R4342	T14647	T14644	pobj	SACs,In
R4343	T14648	T14647	compound	WT,SACs
R4344	T14649	T14645	nsubj	Slc18a3,is
R4345	T14650	T14651	advmod	only,in
R4346	T14651	T14645	prep	in,is
R4347	T14652	T14651	pobj	processes,in
R4348	T14653	T14645	punct	", ",is
R4349	T14654	T14645	cc	but,is
R4350	T14655	T14656	prep	in,found
R4351	T14656	T14645	conj	found,is
R4352	T14657	T14658	amod	early,SACs
R4353	T14658	T14655	pobj	SACs,in
R4354	T14659	T14658	amod	postnatal,SACs
R4355	T14660	T14656	punct	", ",found
R4356	T14661	T14656	nsubjpass	it,found
R4357	T14662	T14656	auxpass	is,found
R4358	T14663	T14656	prep	in,found
R4359	T14664	T14665	det	the,body
R4360	T14665	T14663	pobj	body,in
R4361	T14666	T14665	compound	cell,body
R4362	T14667	T14656	punct	", ",found
R4363	T14668	T14656	cc	and,found
R4364	T14669	T14656	conj	moves,found
R4365	T14670	T14669	prep	into,moves
R4366	T14671	T14672	amod	emerging,processes
R4367	T14672	T14670	pobj	processes,into
R4368	T14673	T14669	prep	at,moves
R4369	T14674	T14675	advmod	approximately,P4
R4370	T14675	T14673	pobj	P4,at
R4371	T14676	T14677	punct	–,P6
R4372	T14677	T14675	prep	P6,P4
R4373	T14678	T14656	punct	.,found
R4374	T14680	T14681	mark	As,noted
R4375	T14699	T14686	punct	;,was
R4376	T14681	T14682	advcl	noted,was
R4377	T14700	T14686	prep	at,was
R4378	T14682	T14686	ccomp	was,was
R4379	T14701	T14700	pobj	P4,at
R4380	T14683	T14681	advmod	above,noted
R4381	T14702	T14701	cc	or,P4
R4382	T14703	T14701	conj	P5,P4
R4383	T14684	T14682	punct	", ",was
R4384	T14704	T14686	nsubj	it,was
R4385	T14705	T14686	prep	in,was
R4386	T14685	T14682	nsubj	Slc18a3,was
R4387	T14706	T14707	compound	cell,bodies
R4388	T14707	T14705	pobj	bodies,in
R4389	T14708	T14686	punct	", ",was
R4390	T14687	T14682	acomp	absent,was
R4391	T14709	T14686	cc	yet,was
R4392	T14710	T14686	conj	was,was
R4393	T14688	T14682	prep	at,was
R4394	T14711	T14710	advmod	rarely,was
R4395	T14712	T14710	acomp	present,was
R4396	T14689	T14688	pobj	P18,at
R4397	T14713	T14710	prep	in,was
R4398	T14714	T14715	compound	Rb,KO
R4399	T14690	T14682	prep	in,was
R4400	T14715	T14716	compound	KO,processes
R4401	T14716	T14713	pobj	processes,in
R4402	T14717	T14718	punct	(,4A
R4403	T14718	T14710	parataxis	4A,was
R4404	T14691	T14692	det	the,retina
R4405	T14719	T14718	compound	Figures,4A
R4406	T14720	T14718	cc	and,4A
R4407	T14692	T14690	pobj	retina,in
R4408	T14721	T14718	conj	S6,4A
R4409	T14722	T14718	punct	),4A
R4410	T14723	T14686	punct	.,was
R4411	T14693	T14694	compound	Rb,KO
R4412	T14694	T14692	compound	KO,retina
R4413	T14725	T14726	nsubj	Slc18a3,became
R4414	T14727	T14728	advmod	virtually,undetectable
R4415	T14728	T14726	acomp	undetectable,became
R4416	T14695	T14696	punct	(,3A
R4417	T14729	T14726	prep	in,became
R4418	T14730	T14731	compound	Rb,KO
R4419	T14696	T14682	parataxis	3A,was
R4420	T14731	T14732	compound	KO,SACs
R4421	T14732	T14729	pobj	SACs,in
R4422	T14733	T14726	prep	by,became
R4423	T14734	T14733	pobj	P8,by
R4424	T14697	T14696	compound	Figure,3A
R4425	T14735	T14736	punct	(,3C
R4426	T14736	T14726	parataxis	3C,became
R4427	T14737	T14736	compound	Figures,3C
R4428	T14738	T14736	cc	and,3C
R4429	T14739	T14736	conj	S6C,3C
R4430	T14740	T14736	punct	),3C
R4431	T14741	T14726	punct	.,became
R4432	T14698	T14696	punct	),3A
R4433	T14743	T14744	det	These,data
R4434	T14744	T14745	nsubj	data,suggest
R4435	T14746	T14747	mark	that,affects
R4436	T14747	T14745	ccomp	affects,suggest
R4437	T14748	T14747	nsubj	Rb,affects
R4438	T14749	T14750	preconj	both,stability
R4439	T14750	T14747	dobj	stability,affects
R4440	T14751	T14750	det	the,stability
R4441	T14752	T14750	compound	synthesis,stability
R4442	T14753	T14750	punct	/,stability
R4443	T14754	T14750	cc	and,stability
R4444	T14755	T14750	conj	transport,stability
R4445	T14756	T14750	prep	of,stability
R4446	T14757	T14758	compound	SAC,markers
R4447	T14758	T14756	pobj	markers,of
R4448	T14759	T14745	punct	.,suggest
R4453	T16394	T16395	nsubj	Rb,Regulates
R4454	T16396	T16397	compound	SAC,Differentiation
R4455	T16397	T16395	dobj	Differentiation,Regulates
R4456	T16398	T16395	prep	through,Regulates
R4457	T16399	T16398	pobj	E2f3,through
R4458	T16401	T16402	nsubj	Rb,binds
R4459	T16403	T16404	amod	more,100
R4460	T16404	T16406	nummod	100,proteins
R4461	T16405	T16404	quantmod	than,100
R4462	T16406	T16402	dobj	proteins,binds
R4463	T16407	T16408	punct	[,43
R4464	T16408	T16402	parataxis	43,binds
R4465	T16409	T16408	punct	],43
R4466	T16410	T16402	cc	and,binds
R4467	T16411	T16412	prep	in,thought
R4468	T16412	T16402	conj	thought,binds
R4469	T16413	T16414	det	some,cells
R4470	T16414	T16411	pobj	cells,in
R4471	T16415	T16414	amod	non-neuronal,cells
R4472	T16416	T16414	punct	", ",cells
R4473	T16417	T16418	amod	such,as
R4474	T16418	T16414	prep	as,cells
R4475	T16419	T16420	amod	skeletal,muscle
R4476	T16420	T16418	pobj	muscle,as
R4477	T16421	T16420	punct	", ",muscle
R4478	T16422	T16420	conj	adipocytes,muscle
R4479	T16423	T16422	punct	", ",adipocytes
R4480	T16424	T16422	cc	and,adipocytes
R4481	T16425	T16422	conj	bone,adipocytes
R4482	T16426	T16412	punct	", ",thought
R4483	T16427	T16412	nsubjpass	Rb,thought
R4484	T16428	T16412	auxpass	is,thought
R4485	T16429	T16430	aux	to,bind
R4486	T16430	T16412	xcomp	bind,thought
R4487	T16431	T16430	cc	and,bind
R4488	T16432	T16430	conj	potentiate,bind
R4489	T16433	T16434	npadvmod	tissue,specific
R4490	T16434	T16436	amod	specific,factors
R4491	T16435	T16434	punct	-,specific
R4492	T16436	T16432	dobj	factors,potentiate
R4493	T16437	T16436	compound	transcription,factors
R4494	T16438	T16439	dep	that,promote
R4495	T16439	T16436	relcl	promote,factors
R4496	T16440	T16439	dobj	differentiation,promote
R4497	T16441	T16442	punct	[,31
R4498	T16442	T16432	parataxis	31,potentiate
R4499	T16443	T16444	punct	–,33
R4500	T16444	T16442	prep	33,31
R4501	T16445	T16442	punct	],31
R4502	T16446	T16412	punct	.,thought
R4503	T16448	T16449	advmod	Thus,expected
R4504	T16450	T16449	punct	", ",expected
R4505	T16451	T16449	nsubj	we,expected
R4506	T16452	T16453	mark	that,interact
R4507	T16453	T16449	ccomp	interact,expected
R4508	T16454	T16453	nsubj	Rb,interact
R4509	T16455	T16453	aux	might,interact
R4510	T16456	T16453	prep	with,interact
R4511	T16457	T16458	npadvmod	retina,specific
R4512	T16458	T16460	amod	specific,factors
R4513	T16459	T16458	punct	-,specific
R4514	T16460	T16456	pobj	factors,with
R4515	T16461	T16462	aux	to,facilitate
R4516	T16462	T16453	advcl	facilitate,interact
R4517	T16463	T16464	compound	SAC,differentiation
R4518	T16464	T16462	dobj	differentiation,facilitate
R4519	T16465	T16449	punct	.,expected
R4520	T16467	T16468	det	A,role
R4521	T16468	T16470	nsubjpass	role,described
R4522	T16469	T16468	amod	direct,role
R4523	T16471	T16468	prep	for,role
R4524	T16472	T16471	pobj	E2f,for
R4525	T16473	T16468	prep	in,role
R4526	T16474	T16473	pcomp	mediating,in
R4527	T16475	T16476	npadvmod	Rb,dependent
R4528	T16476	T16478	amod	dependent,defects
R4529	T16477	T16476	punct	-,dependent
R4530	T16478	T16474	dobj	defects,mediating
R4531	T16479	T16478	compound	differentiation,defects
R4532	T16480	T16478	punct	(,defects
R4533	T16481	T16478	amod	independent,defects
R4534	T16482	T16481	prep	of,independent
R4535	T16483	T16484	nmod	cell,cycle
R4536	T16484	T16485	nmod	cycle,defects
R4537	T16485	T16482	pobj	defects,of
R4538	T16486	T16484	cc	or,cycle
R4539	T16487	T16484	conj	death,cycle
R4540	T16488	T16470	punct	),described
R4541	T16489	T16470	aux	has,described
R4542	T16490	T16470	prep	to,described
R4543	T16491	T16492	poss	our,knowledge
R4544	T16492	T16490	pobj	knowledge,to
R4545	T16493	T16470	neg	not,described
R4546	T16494	T16470	auxpass	been,described
R4547	T16495	T16470	punct	", ",described
R4548	T16496	T16470	cc	but,described
R4549	T16497	T16498	mark	because,regulate
R4550	T16498	T16501	advcl	regulate,tested
R4551	T16499	T16498	nsubj	E2f,regulate
R4552	T16500	T16498	aux	can,regulate
R4553	T16501	T16470	conj	tested,described
R4554	T16502	T16503	det	some,genes
R4555	T16503	T16498	dobj	genes,regulate
R4556	T16504	T16503	compound	differentiation,genes
R4557	T16505	T16506	punct	[,44
R4558	T16506	T16498	parataxis	44,regulate
R4559	T16507	T16508	punct	–,48
R4560	T16508	T16506	prep	48,44
R4561	T16509	T16506	punct	],44
R4562	T16510	T16501	punct	", ",tested
R4563	T16511	T16501	nsubj	we,tested
R4564	T16512	T16501	advmod	first,tested
R4565	T16513	T16514	mark	whether,perturb
R4566	T16514	T16501	ccomp	perturb,tested
R4567	T16515	T16514	nsubj	E2f2,perturb
R4568	T16516	T16515	cc	or,E2f2
R4569	T16517	T16515	conj	E2f3,E2f2
R4570	T16518	T16514	aux	might,perturb
R4571	T16519	T16520	compound	Rb,KO
R4572	T16520	T16521	compound	KO,SAC
R4573	T16521	T16522	compound	SAC,maturation
R4574	T16522	T16514	dobj	maturation,perturb
R4575	T16523	T16501	punct	.,tested
R4576	T16525	T16526	prep	At,suppressed
R4577	T16527	T16528	amod	multiple,points
R4578	T16528	T16525	pobj	points,At
R4579	T16529	T16528	compound	time,points
R4580	T16530	T16526	punct	", ",suppressed
R4581	T16531	T16532	compound	E2f1,deletion
R4582	T16532	T16526	nsubj	deletion,suppressed
R4583	T16533	T16534	amod	ectopic,mitosis
R4584	T16534	T16526	dobj	mitosis,suppressed
R4585	T16535	T16536	punct	(,cells
R4586	T16536	T16526	parataxis	cells,suppressed
R4587	T16537	T16536	nmod	PH3,cells
R4588	T16538	T16537	punct	+,PH3
R4589	T16539	T16536	punct	),cells
R4590	T16540	T16526	punct	", ",suppressed
R4591	T16541	T16526	cc	but,suppressed
R4592	T16542	T16543	aux	did,reverse
R4593	T16543	T16526	conj	reverse,suppressed
R4594	T16544	T16543	neg	not,reverse
R4595	T16545	T16546	det	the,defect
R4596	T16546	T16543	dobj	defect,reverse
R4597	T16547	T16546	compound	SAC,defect
R4598	T16548	T16526	punct	", ",suppressed
R4599	T16549	T16526	cc	and,suppressed
R4600	T16550	T16551	compound	E2f2,deletion
R4601	T16551	T16552	nsubj	deletion,had
R4602	T16552	T16526	conj	had,suppressed
R4603	T16553	T16554	det	no,effect
R4604	T16554	T16552	dobj	effect,had
R4605	T16555	T16554	prep	on,effect
R4606	T16556	T16557	preconj	either,defect
R4607	T16557	T16555	pobj	defect,on
R4608	T16558	T16559	punct	(,4A
R4609	T16559	T16552	parataxis	4A,had
R4610	T16560	T16559	compound	Figure,4A
R4611	T16561	T16559	punct	),4A
R4612	T16562	T16552	punct	.,had
R4613	T16564	T16565	advmod	Remarkably,rescued
R4614	T16566	T16565	punct	", ",rescued
R4615	T16567	T16568	mark	although,reverse
R4616	T16568	T16565	advcl	reverse,rescued
R4617	T16569	T16570	compound	E2f3,deletion
R4618	T16570	T16568	nsubj	deletion,reverse
R4619	T16571	T16568	aux	did,reverse
R4620	T16572	T16568	neg	not,reverse
R4621	T16573	T16574	amod	ectopic,mitosis
R4622	T16574	T16568	dobj	mitosis,reverse
R4623	T16575	T16565	punct	", ",rescued
R4624	T16576	T16565	nsubj	it,rescued
R4625	T16577	T16578	nmod	Calb2,staining
R4626	T16578	T16565	dobj	staining,rescued
R4627	T16579	T16577	punct	", ",Calb2
R4628	T16580	T16577	conj	Slc18a3,Calb2
R4629	T16581	T16580	punct	", ",Slc18a3
R4630	T16582	T16580	conj	Chat,Slc18a3
R4631	T16583	T16582	punct	", ",Chat
R4632	T16584	T16582	conj	GABA,Chat
R4633	T16585	T16584	punct	", ",GABA
R4634	T16586	T16584	conj	Kcnc1b,GABA
R4635	T16587	T16586	punct	", ",Kcnc1b
R4636	T16588	T16586	conj	Kcnc2,Kcnc1b
R4637	T16589	T16588	punct	", ",Kcnc2
R4638	T16590	T16588	cc	and,Kcnc2
R4639	T16591	T16588	conj	Sv2c,Kcnc2
R4640	T16592	T16565	prep	at,rescued
R4641	T16593	T16594	amod	multiple,times
R4642	T16594	T16592	pobj	times,at
R4643	T16595	T16596	punct	(,4A
R4644	T16596	T16565	parataxis	4A,rescued
R4645	T16597	T16596	compound	Figure,4A
R4646	T16598	T16596	cc	and,4A
R4647	T16599	T16600	nsubj	data,shown
R4648	T16600	T16596	conj	shown,4A
R4649	T16601	T16600	neg	not,shown
R4650	T16602	T16600	punct	),shown
R4651	T16603	T16565	punct	.,rescued
R4652	T16605	T16606	compound	Rb,E2f3
R4653	T16606	T16608	compound	E2f3,DKO
R4654	T16607	T16606	punct	/,E2f3
R4655	T16608	T16609	compound	DKO,SAC
R4656	T16609	T16610	compound	SAC,tracks
R4657	T16610	T16611	nsubj	tracks,were
R4658	T16612	T16613	advmod	slightly,more
R4659	T16613	T16614	advmod	more,disordered
R4660	T16614	T16611	acomp	disordered,were
R4661	T16615	T16614	prep	than,disordered
R4662	T16616	T16615	prep	in,than
R4663	T16617	T16618	compound	WT,retina
R4664	T16618	T16616	pobj	retina,in
R4665	T16619	T16611	punct	", ",were
R4666	T16620	T16621	advmod	most,likely
R4667	T16621	T16622	advmod	likely,because
R4668	T16622	T16611	prep	because,were
R4669	T16623	T16622	pcomp	of,because
R4670	T16624	T16625	det	the,absence
R4671	T16625	T16622	pobj	absence,because
R4672	T16626	T16625	prep	of,absence
R4673	T16627	T16628	amod	synaptic,cells
R4674	T16628	T16626	pobj	cells,of
R4675	T16629	T16628	compound	partner,cells
R4676	T16630	T16628	punct	", ",cells
R4677	T16631	T16632	dep	which,killed
R4678	T16632	T16628	relcl	killed,cells
R4679	T16633	T16632	auxpass	are,killed
R4680	T16634	T16632	agent	by,killed
R4681	T16635	T16634	pobj	E2f1,by
R4682	T16636	T16611	punct	.,were
R4683	T16638	T16639	advmod	Indeed,rescued
R4684	T16640	T16639	punct	", ",rescued
R4685	T16641	T16642	det	this,defect
R4686	T16642	T16639	nsubjpass	defect,rescued
R4687	T16643	T16642	amod	minor,defect
R4688	T16644	T16639	auxpass	was,rescued
R4689	T16645	T16639	prep	in,rescued
R4690	T16646	T16647	det	the,retina
R4691	T16647	T16645	pobj	retina,in
R4692	T16648	T16649	nmod	Rb,E2f3
R4693	T16649	T16653	nmod	E2f3,knockout
R4694	T16650	T16649	punct	/,E2f3
R4695	T16651	T16649	nmod	E2f1,E2f3
R4696	T16652	T16649	punct	/,E2f3
R4697	T16653	T16647	compound	knockout,retina
R4698	T16654	T16653	amod	triple,knockout
R4699	T16655	T16647	punct	", ",retina
R4700	T16656	T16657	advmod	where,rescued
R4701	T16657	T16647	relcl	rescued,retina
R4702	T16658	T16659	amod	bipolar,cell
R4703	T16659	T16662	compound	cell,death
R4704	T16660	T16658	cc	and,bipolar
R4705	T16661	T16658	conj	ganglion,bipolar
R4706	T16662	T16657	nsubjpass	death,rescued
R4707	T16663	T16657	auxpass	was,rescued
R4708	T16664	T16657	cc	and,rescued
R4709	T16665	T16666	compound	SAC,differentiation
R4710	T16666	T16667	nsubjpass	differentiation,restored
R4711	T16667	T16657	conj	restored,rescued
R4712	T16668	T16667	auxpass	was,restored
R4713	T16669	T16670	punct	(,4A
R4714	T16670	T16639	parataxis	4A,rescued
R4715	T16671	T16670	compound	Figure,4A
R4716	T16672	T16670	punct	),4A
R4717	T16673	T16639	punct	.,rescued
R4718	T16675	T16676	compound	E2f3,deletion
R4719	T16676	T16677	nsubj	deletion,affect
R4720	T16678	T16676	advmod	alone,deletion
R4721	T16679	T16677	aux	did,affect
R4722	T16680	T16677	neg	not,affect
R4723	T16681	T16682	compound	SAC,differentiation
R4724	T16682	T16677	dobj	differentiation,affect
R4725	T16683	T16684	punct	(,4A
R4726	T16684	T16677	parataxis	4A,affect
R4727	T16685	T16684	compound	Figure,4A
R4728	T16686	T16684	punct	),4A
R4729	T16687	T16677	punct	;,affect
R4730	T16688	T16689	advmod	thus,is
R4731	T16689	T16677	conj	is,affect
R4732	T16690	T16689	punct	", ",is
R4733	T16691	T16689	nsubj	it,is
R4734	T16692	T16693	amod	unleashed,activity
R4735	T16693	T16689	attr	activity,is
R4736	T16694	T16693	compound	E2f3,activity
R4737	T16695	T16696	dep	that,is
R4738	T16696	T16689	ccomp	is,is
R4739	T16697	T16696	acomp	detrimental,is
R4740	T16698	T16689	punct	", ",is
R4741	T16699	T16689	cc	and,is
R4742	T16700	T16701	det	the,role
R4743	T16701	T16703	nsubj	role,is
R4744	T16702	T16701	amod	critical,role
R4745	T16703	T16689	conj	is,is
R4746	T16704	T16701	prep	for,role
R4747	T16705	T16704	pobj	Rb,for
R4748	T16706	T16707	aux	to,inhibit
R4749	T16707	T16703	xcomp	inhibit,is
R4750	T16708	T16707	dobj	E2f3,inhibit
R4751	T16709	T16703	punct	.,is
R4752	T16711	T16712	nsubj	We,quantified
R4753	T16713	T16714	det	the,fraction
R4754	T16714	T16712	dobj	fraction,quantified
R4755	T16715	T16714	prep	of,fraction
R4756	T16716	T16717	nmod	Camk2a,SACs
R4757	T16717	T16715	pobj	SACs,of
R4758	T16718	T16716	punct	+,Camk2a
R4759	T16719	T16714	prep	in,fraction
R4760	T16720	T16721	amod	different,genotypes
R4761	T16721	T16719	pobj	genotypes,in
R4762	T16722	T16712	cc	and,quantified
R4763	T16723	T16712	conj	found,quantified
R4764	T16724	T16725	mark	that,expressed
R4765	T16725	T16723	ccomp	expressed,found
R4766	T16726	T16727	nummod	60,%
R4767	T16727	T16725	nsubj	%,expressed
R4768	T16728	T16727	prep	of,%
R4769	T16729	T16730	nmod	WT,cells
R4770	T16730	T16728	pobj	cells,of
R4771	T16731	T16730	nmod	P30,cells
R4772	T16732	T16730	nmod	Camk2a,cells
R4773	T16733	T16732	punct	+,Camk2a
R4774	T16734	T16725	dobj	Chat,expressed
R4775	T16735	T16734	cc	and,Chat
R4776	T16736	T16734	conj	Slc18a3,Chat
R4777	T16737	T16725	punct	", ",expressed
R4778	T16738	T16739	dep	which,dropped
R4779	T16739	T16725	ccomp	dropped,expressed
R4780	T16740	T16739	prep	to,dropped
R4781	T16741	T16742	advmod	only,5.6
R4782	T16742	T16743	nummod	5.6,%
R4783	T16743	T16740	pobj	%,to
R4784	T16744	T16739	prep	in,dropped
R4785	T16745	T16746	det	the,retina
R4786	T16746	T16744	pobj	retina,in
R4787	T16747	T16748	compound	Rb,KO
R4788	T16748	T16746	compound	KO,retina
R4789	T16749	T16739	punct	", ",dropped
R4790	T16750	T16739	cc	and,dropped
R4791	T16751	T16739	conj	remained,dropped
R4792	T16752	T16751	acomp	low,remained
R4793	T16753	T16751	prep	at,remained
R4794	T16754	T16755	nummod	3.7,%
R4795	T16755	T16753	pobj	%,at
R4796	T16756	T16751	prep	in,remained
R4797	T16757	T16758	det	the,retina
R4798	T16758	T16756	pobj	retina,in
R4799	T16759	T16760	compound	Rb,E2f1
R4800	T16760	T16762	compound	E2f1,DKO
R4801	T16761	T16760	punct	/,E2f1
R4802	T16762	T16758	compound	DKO,retina
R4803	T16763	T16751	punct	", ",remained
R4804	T16764	T16751	cc	but,remained
R4805	T16765	T16751	conj	rose,remained
R4806	T16766	T16765	prep	to,rose
R4807	T16767	T16768	nummod	91,%
R4808	T16768	T16766	pobj	%,to
R4809	T16769	T16765	prep	in,rose
R4810	T16770	T16771	det	the,retina
R4811	T16771	T16769	pobj	retina,in
R4812	T16772	T16773	compound	Rb,E2f3
R4813	T16773	T16775	compound	E2f3,DKO
R4814	T16774	T16773	punct	/,E2f3
R4815	T16775	T16771	compound	DKO,retina
R4816	T16776	T16777	punct	(,4B
R4817	T16777	T16765	parataxis	4B,rose
R4818	T16778	T16777	compound	Figure,4B
R4819	T16779	T16777	punct	),4B
R4820	T16780	T16712	punct	.,quantified
R4821	T16782	T16783	det	The,fraction
R4822	T16783	T16785	nsubj	fraction,is
R4823	T16784	T16783	amod	latter,fraction
R4824	T16786	T16785	acomp	higher,is
R4825	T16787	T16786	prep	than,higher
R4826	T16788	T16787	pobj	WT,than
R4827	T16789	T16790	mark	because,killed
R4828	T16790	T16785	advcl	killed,is
R4829	T16791	T16792	compound	ganglion,cells
R4830	T16792	T16790	nsubjpass	cells,killed
R4831	T16793	T16792	punct	", ",cells
R4832	T16794	T16795	dep	which,make
R4833	T16795	T16792	relcl	make,cells
R4834	T16796	T16795	advmod	normally,make
R4835	T16797	T16795	prt	up,make
R4836	T16798	T16799	punct	~,40
R4837	T16799	T16800	nummod	40,%
R4838	T16800	T16795	dobj	%,make
R4839	T16801	T16800	prep	of,%
R4840	T16802	T16803	nmod	Camk2a,cells
R4841	T16803	T16801	pobj	cells,of
R4842	T16804	T16802	punct	+,Camk2a
R4843	T16805	T16790	punct	", ",killed
R4844	T16806	T16790	auxpass	are,killed
R4845	T16807	T16790	agent	by,killed
R4846	T16808	T16807	pobj	apoptosis,by
R4847	T16809	T16785	punct	.,is
R4848	T16811	T16812	aux	To,quantify
R4849	T16812	T16813	advcl	quantify,exploited
R4850	T16814	T16815	det	the,effect
R4851	T16815	T16812	dobj	effect,quantify
R4852	T16816	T16815	prep	of,effect
R4853	T16817	T16818	amod	different,E2fs
R4854	T16818	T16816	pobj	E2fs,of
R4855	T16819	T16815	prep	on,effect
R4856	T16820	T16821	amod	ectopic,division
R4857	T16821	T16819	pobj	division,on
R4858	T16822	T16823	advmod	specifically,in
R4859	T16823	T16815	prep	in,effect
R4860	T16824	T16823	pobj	SACs,in
R4861	T16825	T16813	punct	", ",exploited
R4862	T16826	T16813	nsubj	we,exploited
R4863	T16827	T16813	dobj	Isl1,exploited
R4864	T16828	T16827	punct	(,Isl1
R4865	T16829	T16827	appos	Islet1,Isl1
R4866	T16830	T16813	punct	),exploited
R4867	T16831	T16813	punct	.,exploited
R4868	T16833	T16834	det	This,marker
R4869	T16834	T16835	nsubjpass	marker,expressed
R4870	T16835	T16837	ccomp	expressed,are
R4871	T16836	T16835	auxpass	is,expressed
R4872	T16838	T16835	prep	in,expressed
R4873	T16839	T16840	preconj	both,SACs
R4874	T16840	T16838	pobj	SACs,in
R4875	T16841	T16840	cc	and,SACs
R4876	T16842	T16843	compound	ganglion,cells
R4877	T16843	T16840	conj	cells,SACs
R4878	T16844	T16837	punct	", ",are
R4879	T16845	T16837	advmod	thus,are
R4880	T16846	T16847	nmod	Isl1,cells
R4881	T16847	T16837	nsubj	cells,are
R4882	T16848	T16846	punct	+,Isl1
R4883	T16849	T16847	prep	in,cells
R4884	T16850	T16851	det	the,INL
R4885	T16851	T16849	pobj	INL,in
R4886	T16852	T16837	advmod	exclusively,are
R4887	T16853	T16837	attr	SACs,are
R4888	T16854	T16855	punct	[,49
R4889	T16855	T16837	parataxis	49,are
R4890	T16856	T16855	punct	],49
R4891	T16857	T16837	punct	.,are
R4892	T16859	T16860	nsubj	We,found
R4893	T16861	T16862	mark	that,were
R4894	T16862	T16860	ccomp	were,found
R4895	T16863	T16864	nummod	98.2,%
R4896	T16864	T16862	nsubj	%,were
R4897	T16865	T16864	punct	±,%
R4898	T16866	T16867	nummod	1.8,%
R4899	T16867	T16864	appos	%,%
R4900	T16868	T16864	prep	of,%
R4901	T16869	T16870	nmod	Isl1,cells
R4902	T16870	T16868	pobj	cells,of
R4903	T16871	T16869	punct	+,Isl1
R4904	T16872	T16864	prep	in,%
R4905	T16873	T16874	det	the,INL
R4906	T16874	T16872	pobj	INL,in
R4907	T16875	T16874	amod	forming,INL
R4908	T16876	T16874	amod	inner,INL
R4909	T16877	T16864	prep	at,%
R4910	T16878	T16877	pobj	P5,at
R4911	T16879	T16862	advmod	also,were
R4912	T16880	T16862	attr	Slc18a3,were
R4913	T16881	T16880	punct	+,Slc18a3
R4914	T16882	T16860	punct	", ",found
R4915	T16883	T16860	advcl	confirming,found
R4916	T16884	T16885	mark	that,is
R4917	T16885	T16883	ccomp	is,confirming
R4918	T16886	T16885	nsubj	Isl1,is
R4919	T16887	T16888	det	an,marker
R4920	T16888	T16885	attr	marker,is
R4921	T16889	T16888	amod	excellent,marker
R4922	T16890	T16888	compound	SAC,marker
R4923	T16891	T16892	punct	(,4C
R4924	T16892	T16885	parataxis	4C,is
R4925	T16893	T16892	compound	Figure,4C
R4926	T16894	T16892	punct	),4C
R4927	T16895	T16860	punct	.,found
R4928	T16897	T16898	advmod	Moreover,is
R4929	T16899	T16898	punct	", ",is
R4930	T16900	T16898	nsubj	Isl1,is
R4931	T16901	T16900	punct	", ",Isl1
R4932	T16902	T16900	prep	unlike,Isl1
R4933	T16903	T16902	pobj	Slc18a3,unlike
R4934	T16904	T16898	punct	", ",is
R4935	T16905	T16898	acomp	nuclear,is
R4936	T16906	T16898	punct	", ",is
R4937	T16907	T16908	dep	which,facilitates
R4938	T16908	T16898	advcl	facilitates,is
R4939	T16909	T16908	dobj	scoring,facilitates
R4940	T16910	T16909	prep	of,scoring
R4941	T16911	T16912	nmod	Isl1,cells
R4942	T16912	T16910	pobj	cells,of
R4943	T16913	T16911	punct	+,Isl1
R4944	T16914	T16911	punct	/,Isl1
R4945	T16915	T16911	appos	Mki67,Isl1
R4946	T16916	T16915	punct	+,Mki67
R4947	T16917	T16898	punct	.,is
R4948	T16919	T16920	nsubjpass	It,expressed
R4949	T16920	T16923	ccomp	expressed,study
R4950	T16921	T16920	auxpass	is,expressed
R4951	T16922	T16920	advmod	also,expressed
R4952	T16924	T16920	advmod	earlier,expressed
R4953	T16925	T16924	prep	than,earlier
R4954	T16926	T16925	pobj	Slc18a3,than
R4955	T16927	T16920	punct	", ",expressed
R4956	T16928	T16920	advcl	permitting,expressed
R4957	T16929	T16928	dobj	analysis,permitting
R4958	T16930	T16929	prep	of,analysis
R4959	T16931	T16930	pobj	SACs,of
R4960	T16932	T16933	advmod	soon,after
R4961	T16933	T16928	prep	after,permitting
R4962	T16934	T16935	poss	their,birth
R4963	T16935	T16933	pobj	birth,after
R4964	T16936	T16935	prep	at,birth
R4965	T16937	T16938	punct	~,E15
R4966	T16938	T16936	pobj	E15,at
R4967	T16939	T16923	punct	;,study
R4968	T16940	T16923	advmod	thus,study
R4969	T16941	T16923	punct	", ",study
R4970	T16942	T16923	nsubj	we,study
R4971	T16943	T16923	aux	could,study
R4972	T16944	T16923	dobj	retina,study
R4973	T16945	T16923	prep	at,study
R4974	T16946	T16945	pobj	P0,at
R4975	T16947	T16946	punct	", ",P0
R4976	T16948	T16949	det	a,time
R4977	T16949	T16946	appos	time,P0
R4978	T16950	T16951	advmod	when,is
R4979	T16951	T16949	relcl	is,time
R4980	T16952	T16953	amod	ectopic,division
R4981	T16953	T16951	nsubj	division,is
R4982	T16954	T16951	acomp	high,is
R4983	T16955	T16951	prep	in,is
R4984	T16956	T16957	det	the,retina
R4985	T16957	T16955	pobj	retina,in
R4986	T16958	T16957	amod	inner,retina
R4987	T16959	T16945	cc	and,at
R4988	T16960	T16961	advmod	prior,to
R4989	T16961	T16945	conj	to,at
R4990	T16962	T16963	npadvmod	Rb,independent
R4991	T16963	T16965	amod	independent,exit
R4992	T16964	T16963	punct	-,independent
R4993	T16965	T16961	pobj	exit,to
R4994	T16966	T16967	compound	cell,cycle
R4995	T16967	T16965	compound	cycle,exit
R4996	T16968	T16965	acl	associated,exit
R4997	T16969	T16968	prep	with,associated
R4998	T16970	T16971	amod	terminal,differentiation
R4999	T16971	T16969	pobj	differentiation,with
R5000	T16972	T16973	punct	[,2
R5001	T16973	T16923	parataxis	2,study
R5002	T16974	T16973	punct	],2
R5003	T16975	T16923	punct	.,study
R5004	T16977	T16978	prep	At,dividing
R5005	T16979	T16977	pobj	P0,At
R5006	T16980	T16978	punct	", ",dividing
R5007	T16981	T16982	det	no,cells
R5008	T16982	T16978	nsubj	cells,dividing
R5009	T16983	T16982	nmod	WT,cells
R5010	T16984	T16982	nmod	Isl1,cells
R5011	T16985	T16984	punct	+,Isl1
R5012	T16986	T16982	prep	in,cells
R5013	T16987	T16988	det	the,layer
R5014	T16988	T16986	pobj	layer,in
R5015	T16989	T16988	amod	inner,layer
R5016	T16990	T16988	amod	neuroblastic,layer
R5017	T16991	T16988	punct	(,layer
R5018	T16992	T16988	appos	NBL,layer
R5019	T16993	T16988	punct	),layer
R5020	T16994	T16988	punct	(,layer
R5021	T16995	T16996	dep	which,is
R5022	T16996	T16988	relcl	is,layer
R5023	T16997	T16998	det	the,INL
R5024	T16998	T16996	attr	INL,is
R5025	T16999	T16998	amod	future,INL
R5026	T17000	T16978	punct	),dividing
R5027	T17001	T16978	aux	were,dividing
R5028	T17002	T16978	punct	", ",dividing
R5029	T17003	T16978	cc	but,dividing
R5030	T17004	T17005	quantmod	57,14
R5031	T17005	T17007	nummod	14,cells
R5032	T17006	T17005	punct	±,14
R5033	T17007	T17013	nsubjpass	cells,detected
R5034	T17008	T17007	nmod	Isl1,cells
R5035	T17009	T17008	punct	+,Isl1
R5036	T17010	T17008	punct	/,Isl1
R5037	T17011	T17008	appos	Mki67,Isl1
R5038	T17012	T17011	punct	+,Mki67
R5039	T17013	T16978	conj	detected,dividing
R5040	T17014	T17013	auxpass	were,detected
R5041	T17015	T17013	prep	in,detected
R5042	T17016	T17017	det	the,NBL
R5043	T17017	T17015	pobj	NBL,in
R5044	T17018	T17019	nmod	Rb,KO
R5045	T17019	T17017	nmod	KO,NBL
R5046	T17020	T17017	amod	inner,NBL
R5047	T17021	T17022	punct	(,4D
R5048	T17022	T17013	parataxis	4D,detected
R5049	T17023	T17022	compound	Figure,4D
R5050	T17024	T17022	punct	),4D
R5051	T17025	T17013	punct	.,detected
R5052	T17027	T17028	advmod	Indeed,dividing
R5053	T17029	T17028	punct	", ",dividing
R5054	T17030	T17031	quantmod	about,one
R5055	T17031	T17028	nsubj	one,dividing
R5056	T17032	T17031	punct	-,one
R5057	T17033	T17031	quantmod	third,one
R5058	T17034	T17031	prep	of,one
R5059	T17035	T17036	det	all,cells
R5060	T17036	T17034	pobj	cells,of
R5061	T17037	T17036	nmod	Isl1,cells
R5062	T17038	T17037	punct	+,Isl1
R5063	T17039	T17031	prep	in,one
R5064	T17040	T17041	det	the,NBL
R5065	T17041	T17039	pobj	NBL,in
R5066	T17042	T17041	amod	entire,NBL
R5067	T17043	T17041	amod	inner,NBL
R5068	T17044	T17028	aux	were,dividing
R5069	T17045	T17028	prep	in,dividing
R5070	T17046	T17047	det	the,retina
R5071	T17047	T17045	pobj	retina,in
R5072	T17048	T17049	compound	Rb,KO
R5073	T17049	T17047	compound	KO,retina
R5074	T17050	T17028	punct	", ",dividing
R5075	T17051	T17028	cc	or,dividing
R5076	T17052	T17053	punct	~,50
R5077	T17053	T17054	nummod	50,%
R5078	T17054	T17028	conj	%,dividing
R5079	T17055	T17054	prep	in,%
R5080	T17056	T17057	det	the,periphery
R5081	T17057	T17055	pobj	periphery,in
R5082	T17058	T17059	advmod	where,expressed
R5083	T17059	T17057	relcl	expressed,periphery
R5084	T17060	T17059	nsubjpass	Cre,expressed
R5085	T17061	T17059	auxpass	is,expressed
R5086	T17062	T17063	punct	(,4E
R5087	T17063	T17054	parataxis	4E,%
R5088	T17064	T17063	compound	Figure,4E
R5089	T17065	T17063	cc	and,4E
R5090	T17066	T17067	nsubj	data,shown
R5091	T17067	T17063	conj	shown,4E
R5092	T17068	T17067	neg	not,shown
R5093	T17069	T17067	punct	),shown
R5094	T17070	T17054	punct	.,%
R5095	T17072	T17073	det	This,defect
R5096	T17073	T17074	nsubjpass	defect,suppressed
R5097	T17075	T17074	auxpass	was,suppressed
R5098	T17076	T17074	prep	in,suppressed
R5099	T17077	T17078	det	the,retina
R5100	T17078	T17076	pobj	retina,in
R5101	T17079	T17080	compound	Rb,E2f1
R5102	T17080	T17082	compound	E2f1,DKO
R5103	T17081	T17080	punct	/,E2f1
R5104	T17082	T17078	compound	DKO,retina
R5105	T17083	T17078	punct	", ",retina
R5106	T17084	T17085	advmod	where,detected
R5107	T17085	T17078	relcl	detected,retina
R5108	T17086	T17085	nsubj	we,detected
R5109	T17087	T17088	advmod	only,1
R5110	T17088	T17091	nummod	1,SAC
R5111	T17089	T17088	quantmod	1,1
R5112	T17090	T17088	punct	±,1
R5113	T17091	T17085	dobj	SAC,detected
R5114	T17092	T17091	compound	dividing,SAC
R5115	T17093	T17078	punct	", ",retina
R5116	T17094	T17078	cc	but,retina
R5117	T17095	T17094	neg	not,but
R5118	T17096	T17097	det	the,retina
R5119	T17097	T17078	conj	retina,retina
R5120	T17098	T17099	compound	Rb,E2f3
R5121	T17099	T17101	compound	E2f3,DKO
R5122	T17100	T17099	punct	/,E2f3
R5123	T17101	T17097	compound	DKO,retina
R5124	T17102	T17097	punct	", ",retina
R5125	T17103	T17104	advmod	where,were
R5126	T17104	T17097	relcl	were,retina
R5127	T17105	T17104	expl	there,were
R5128	T17106	T17107	quantmod	53,8
R5129	T17107	T17109	nummod	8,SACs
R5130	T17108	T17107	punct	±,8
R5131	T17109	T17104	attr	SACs,were
R5132	T17110	T17109	amod	dividing,SACs
R5133	T17111	T17112	punct	(,4D
R5134	T17112	T17104	parataxis	4D,were
R5135	T17113	T17112	compound	Figure,4D
R5136	T17114	T17112	cc	and,4D
R5137	T17115	T17112	conj	4E,4D
R5138	T17116	T17112	punct	),4D
R5139	T17117	T17074	punct	.,suppressed
R5140	T17119	T17120	nsubj	We,observed
R5141	T17121	T17122	amod	similar,effects
R5142	T17122	T17120	dobj	effects,observed
R5143	T17123	T17120	prep	at,observed
R5144	T17124	T17123	pobj	P0,at
R5145	T17125	T17120	prep	with,observed
R5146	T17126	T17125	pobj	Calb2,with
R5147	T17127	T17126	punct	", ",Calb2
R5148	T17128	T17129	dep	which,marks
R5149	T17129	T17126	relcl	marks,Calb2
R5150	T17130	T17131	amod	newborn,SACs
R5151	T17131	T17129	dobj	SACs,marks
R5152	T17132	T17131	cc	and,SACs
R5153	T17133	T17134	amod	other,cells
R5154	T17134	T17131	conj	cells,SACs
R5155	T17135	T17134	amod	amacrine,cells
R5156	T17136	T17137	punct	(,shown
R5157	T17137	T17120	parataxis	shown,observed
R5158	T17138	T17137	nsubj	data,shown
R5159	T17139	T17137	neg	not,shown
R5160	T17140	T17137	punct	),shown
R5161	T17141	T17120	punct	.,observed
R5162	T17143	T17144	advmod	Thus,suppresses
R5163	T17145	T17144	punct	", ",suppresses
R5164	T17146	T17144	prep	in,suppresses
R5165	T17147	T17148	compound	Rb,KO
R5166	T17148	T17149	compound	KO,SACs
R5167	T17149	T17146	pobj	SACs,in
R5168	T17150	T17144	punct	", ",suppresses
R5169	T17151	T17152	compound	E2f1,deletion
R5170	T17152	T17144	nsubj	deletion,suppresses
R5171	T17153	T17154	amod	ectopic,division
R5172	T17154	T17144	dobj	division,suppresses
R5173	T17155	T17154	cc	but,division
R5174	T17156	T17155	neg	not,but
R5175	T17157	T17158	amod	aberrant,differentiation
R5176	T17158	T17154	conj	differentiation,division
R5177	T17159	T17144	punct	", ",suppresses
R5178	T17160	T17161	mark	whereas,suppresses
R5179	T17161	T17144	advcl	suppresses,suppresses
R5180	T17162	T17163	compound	E2f3,deletion
R5181	T17163	T17161	nsubj	deletion,suppresses
R5182	T17164	T17165	amod	aberrant,differentiation
R5183	T17165	T17161	dobj	differentiation,suppresses
R5184	T17166	T17165	cc	but,differentiation
R5185	T17167	T17166	neg	not,but
R5186	T17168	T17169	amod	ectopic,division
R5187	T17169	T17165	conj	division,differentiation
R5188	T17170	T17144	punct	.,suppresses
R5195	T18365	T18366	amod	Specific,Expression
R5196	T18367	T18366	prep	of,Expression
R5197	T18368	T18367	pobj	E2f3,of
R5198	T18369	T18366	prep	in,Expression
R5199	T18370	T18369	pobj	SACs,in
R5200	T18371	T18370	cc	and,SACs
R5201	T18372	T18373	amod	Other,Subsets
R5202	T18373	T18370	conj	Subsets,SACs
R5203	T18374	T18373	prep	of,Subsets
R5204	T18375	T18376	compound	CNS,Neurons
R5205	T18376	T18374	pobj	Neurons,of
R5206	T18378	T18379	det	The,effect
R5207	T18379	T18381	nsubj	effect,be
R5208	T18380	T18379	amod	unique,effect
R5209	T18382	T18379	prep	of,effect
R5210	T18383	T18382	pobj	E2f3,of
R5211	T18384	T18379	prep	in,effect
R5212	T18385	T18384	pcomp	disrupting,in
R5213	T18386	T18387	det	the,differentiation
R5214	T18387	T18385	dobj	differentiation,disrupting
R5215	T18388	T18387	prep	of,differentiation
R5216	T18389	T18388	pobj	SACs,of
R5217	T18390	T18389	cc	but,SACs
R5218	T18391	T18390	neg	not,but
R5219	T18392	T18393	amod	other,neurons
R5220	T18393	T18389	conj	neurons,SACs
R5221	T18394	T18393	amod	retinal,neurons
R5222	T18395	T18381	aux	might,be
R5223	T18396	T18381	prep	due,be
R5224	T18397	T18396	pcomp	to,due
R5225	T18398	T18399	compound	cell,type
R5226	T18399	T18401	npadvmod	type,specific
R5227	T18400	T18399	punct	-,type
R5228	T18401	T18403	amod	specific,expression
R5229	T18402	T18401	punct	-,specific
R5230	T18403	T18396	pobj	expression,due
R5231	T18404	T18403	cc	or,expression
R5232	T18405	T18406	compound	cell,type
R5233	T18406	T18408	npadvmod	type,specific
R5234	T18407	T18406	punct	-,type
R5235	T18408	T18410	amod	specific,activity
R5236	T18409	T18408	punct	-,specific
R5237	T18410	T18403	conj	activity,expression
R5238	T18411	T18403	prep	of,expression
R5239	T18412	T18411	pobj	E2f3,of
R5240	T18413	T18381	punct	.,be
R5241	T18415	T18416	csubj	Determining,is
R5242	T18417	T18415	prep	between,Determining
R5243	T18418	T18419	det	these,possibilities
R5244	T18419	T18417	pobj	possibilities,between
R5245	T18420	T18419	nummod	two,possibilities
R5246	T18421	T18416	neg	not,is
R5247	T18422	T18416	acomp	easy,is
R5248	T18423	T18416	punct	", ",is
R5249	T18424	T18425	mark	as,is
R5250	T18425	T18416	advcl	is,is
R5251	T18426	T18427	compound	E2f,immunostaining
R5252	T18427	T18425	nsubj	immunostaining,is
R5253	T18428	T18427	prep	in,immunostaining
R5254	T18429	T18430	compound	mouse,tissues
R5255	T18430	T18428	pobj	tissues,in
R5256	T18431	T18425	acomp	problematic,is
R5257	T18432	T18416	punct	.,is
R5258	T18434	T18435	nsubj	We,solve
R5259	T18436	T18435	aux	did,solve
R5260	T18437	T18435	neg	not,solve
R5261	T18438	T18439	det	this,issue
R5262	T18439	T18435	dobj	issue,solve
R5263	T18440	T18435	prep	for,solve
R5264	T18441	T18440	pobj	E2f1,for
R5265	T18442	T18441	cc	or,E2f1
R5266	T18443	T18441	conj	E2f2,E2f1
R5267	T18444	T18435	punct	", ",solve
R5268	T18445	T18435	cc	but,solve
R5269	T18446	T18435	conj	used,solve
R5270	T18447	T18448	det	a,protocol
R5271	T18448	T18446	dobj	protocol,used
R5272	T18449	T18448	amod	modified,protocol
R5273	T18450	T18451	punct	[,50
R5274	T18451	T18448	parataxis	50,protocol
R5275	T18452	T18451	punct	],50
R5276	T18453	T18454	aux	to,track
R5277	T18454	T18446	advcl	track,used
R5278	T18455	T18454	advmod	successfully,track
R5279	T18456	T18457	compound	E2f3,expression
R5280	T18457	T18454	dobj	expression,track
R5281	T18458	T18459	punct	(,Figure
R5282	T18459	T18454	parataxis	Figure,track
R5283	T18460	T18459	nummod	5,Figure
R5284	T18461	T18459	punct	),Figure
R5285	T18462	T18435	punct	.,solve
R5286	T18464	T18465	prep	At,detected
R5287	T18466	T18464	pobj	P0,At
R5288	T18467	T18465	punct	", ",detected
R5289	T18468	T18465	nsubjpass	E2f3,detected
R5290	T18469	T18465	auxpass	was,detected
R5291	T18470	T18465	prep	in,detected
R5292	T18471	T18470	pobj	RPCs,in
R5293	T18472	T18465	punct	", ",detected
R5294	T18473	T18465	advcl	consistent,detected
R5295	T18474	T18473	prep	with,consistent
R5296	T18475	T18476	det	a,role
R5297	T18476	T18474	pobj	role,with
R5298	T18477	T18476	amod	putative,role
R5299	T18478	T18476	prep	in,role
R5300	T18479	T18480	amod	normal,proliferation
R5301	T18480	T18478	pobj	proliferation,in
R5302	T18481	T18482	punct	(,5A
R5303	T18482	T18465	parataxis	5A,detected
R5304	T18483	T18482	compound	Figure,5A
R5305	T18484	T18482	punct	),5A
R5306	T18485	T18465	punct	.,detected
R5307	T18487	T18488	det	The,signal
R5308	T18488	T18489	nsubj	signal,was
R5309	T18490	T18489	acomp	specific,was
R5310	T18491	T18492	mark	as,was
R5311	T18492	T18489	advcl	was,was
R5312	T18493	T18492	nsubj	it,was
R5313	T18494	T18492	acomp	absent,was
R5314	T18495	T18492	prep	in,was
R5315	T18496	T18497	det	the,retina
R5316	T18497	T18495	pobj	retina,in
R5317	T18498	T18499	nmod	E2f3,KO
R5318	T18499	T18497	nmod	KO,retina
R5319	T18500	T18497	amod	peripheral,retina
R5320	T18501	T18502	punct	(,5A
R5321	T18502	T18492	parataxis	5A,was
R5322	T18503	T18502	compound	Figure,5A
R5323	T18504	T18502	punct	),5A
R5324	T18505	T18489	punct	.,was
R5325	T18507	T18508	mark	As,differentiated
R5326	T18508	T18511	advcl	differentiated,dropped
R5327	T18509	T18510	det	the,retina
R5328	T18510	T18508	nsubj	retina,differentiated
R5329	T18512	T18508	cc	and,differentiated
R5330	T18513	T18514	compound	RPC,division
R5331	T18514	T18515	nsubj	division,diminished
R5332	T18515	T18508	conj	diminished,differentiated
R5333	T18516	T18511	punct	", ",dropped
R5334	T18517	T18518	det	the,number
R5335	T18518	T18511	nsubj	number,dropped
R5336	T18519	T18518	prep	of,number
R5337	T18520	T18521	nmod	E2f3,cells
R5338	T18521	T18519	pobj	cells,of
R5339	T18522	T18520	punct	+,E2f3
R5340	T18523	T18511	advmod	also,dropped
R5341	T18524	T18511	punct	", ",dropped
R5342	T18525	T18511	cc	and,dropped
R5343	T18526	T18527	prep	by,expressed
R5344	T18527	T18511	conj	expressed,dropped
R5345	T18528	T18526	pobj	P8,by
R5346	T18529	T18527	punct	", ",expressed
R5347	T18530	T18531	advmod	when,is
R5348	T18531	T18527	advcl	is,expressed
R5349	T18532	T18531	nsubj	division,is
R5350	T18533	T18534	advmod	virtually,over
R5351	T18534	T18531	advmod	over,is
R5352	T18535	T18527	punct	", ",expressed
R5353	T18536	T18537	advmod	only,subset
R5354	T18537	T18527	nsubj	subset,expressed
R5355	T18538	T18537	det	a,subset
R5356	T18539	T18537	prep	of,subset
R5357	T18540	T18541	amod	post-mitotic,cells
R5358	T18541	T18539	pobj	cells,of
R5359	T18542	T18537	prep	in,subset
R5360	T18543	T18544	det	the,retina
R5361	T18544	T18542	pobj	retina,in
R5362	T18545	T18544	amod	inner,retina
R5363	T18546	T18527	dobj	E2f3,expressed
R5364	T18547	T18548	punct	(,5A
R5365	T18548	T18527	parataxis	5A,expressed
R5366	T18549	T18548	compound	Figure,5A
R5367	T18550	T18548	punct	),5A
R5368	T18551	T18527	punct	.,expressed
R5369	T18553	T18554	prep	By,detected
R5370	T18555	T18553	pobj	P18,By
R5371	T18556	T18554	punct	", ",detected
R5372	T18557	T18554	nsubjpass	E2f3,detected
R5373	T18558	T18554	auxpass	was,detected
R5374	T18559	T18554	advmod	also,detected
R5375	T18560	T18554	prep	in,detected
R5376	T18561	T18562	nummod	two,tracks
R5377	T18562	T18560	pobj	tracks,in
R5378	T18563	T18562	prep	in,tracks
R5379	T18564	T18565	det	the,IPL
R5380	T18565	T18563	pobj	IPL,in
R5381	T18566	T18567	punct	(,5A
R5382	T18567	T18562	parataxis	5A,tracks
R5383	T18568	T18567	compound	Figure,5A
R5384	T18569	T18567	cc	and,5A
R5385	T18570	T18567	conj	5B,5A
R5386	T18571	T18567	punct	),5A
R5387	T18572	T18554	punct	", ",detected
R5388	T18573	T18554	advcl	reminiscent,detected
R5389	T18574	T18573	prep	of,reminiscent
R5390	T18575	T18576	compound	SAC,markers
R5391	T18576	T18574	pobj	markers,of
R5392	T18577	T18578	amod	such,as
R5393	T18578	T18576	prep	as,markers
R5394	T18579	T18578	pobj	Chat,as
R5395	T18580	T18579	cc	and,Chat
R5396	T18581	T18579	conj	Slc18a3,Chat
R5397	T18582	T18583	punct	(,3
R5398	T18583	T18554	parataxis	3,detected
R5399	T18584	T18583	advmod	c.f.,3
R5400	T18585	T18583	nmod	Figures,3
R5401	T18586	T18583	cc	and,3
R5402	T18587	T18583	conj	4,3
R5403	T18588	T18583	punct	),3
R5404	T18589	T18554	punct	.,detected
R5405	T18591	T18592	det	This,staining
R5406	T18592	T18595	nsubj	staining,was
R5407	T18593	T18592	amod	cytoplasmic,staining
R5408	T18594	T18592	compound	E2f3,staining
R5409	T18596	T18595	advmod	also,was
R5410	T18597	T18595	acomp	specific,was
R5411	T18598	T18595	punct	", ",was
R5412	T18599	T18600	mark	as,was
R5413	T18600	T18595	advcl	was,was
R5414	T18601	T18600	nsubj	it,was
R5415	T18602	T18600	acomp	absent,was
R5416	T18603	T18600	prep	in,was
R5417	T18604	T18605	det	the,retina
R5418	T18605	T18603	pobj	retina,in
R5419	T18606	T18607	nmod	E2f3,KO
R5420	T18607	T18605	nmod	KO,retina
R5421	T18608	T18605	amod	peripheral,retina
R5422	T18609	T18605	prep	of,retina
R5423	T18610	T18611	nmod	α,Cre
R5424	T18611	T18613	nmod	Cre,mice
R5425	T18612	T18611	punct	-,Cre
R5426	T18613	T18609	pobj	mice,of
R5427	T18614	T18611	punct	;,Cre
R5428	T18615	T18616	compound	E2f3loxP,loxP
R5429	T18616	T18611	appos	loxP,Cre
R5430	T18617	T18616	punct	/,loxP
R5431	T18618	T18619	punct	(,5A
R5432	T18619	T18595	parataxis	5A,was
R5433	T18620	T18619	compound	Figure,5A
R5434	T18621	T18619	punct	),5A
R5435	T18622	T18595	punct	.,was
R5436	T18624	T18625	advmod	Indeed,confirmed
R5437	T18626	T18625	punct	", ",confirmed
R5438	T18627	T18628	amod	double,labelling
R5439	T18628	T18625	nsubj	labelling,confirmed
R5440	T18629	T18628	prep	with,labelling
R5441	T18630	T18629	pobj	E2f3,with
R5442	T18631	T18632	punct	(,red
R5443	T18632	T18630	parataxis	red,E2f3
R5444	T18633	T18632	punct	),red
R5445	T18634	T18630	cc	and,E2f3
R5446	T18635	T18630	conj	Chat,E2f3
R5447	T18636	T18635	cc	plus,Chat
R5448	T18637	T18635	conj	Slc18a3,Chat
R5449	T18638	T18639	punct	(,green
R5450	T18639	T18637	parataxis	green,Slc18a3
R5451	T18640	T18639	punct	),green
R5452	T18641	T18642	mark	that,is
R5453	T18642	T18625	ccomp	is,confirmed
R5454	T18643	T18642	nsubj	E2f3,is
R5455	T18644	T18642	acomp	present,is
R5456	T18645	T18642	prep	in,is
R5457	T18646	T18647	preconj	both,soma
R5458	T18647	T18645	pobj	soma,in
R5459	T18648	T18647	compound	SAC,soma
R5460	T18649	T18647	cc	and,soma
R5461	T18650	T18647	conj	dendrites,soma
R5462	T18651	T18652	punct	(,5B
R5463	T18652	T18625	parataxis	5B,confirmed
R5464	T18653	T18652	compound	Figure,5B
R5465	T18654	T18652	punct	),5B
R5466	T18655	T18625	punct	.,confirmed
R5467	T18657	T18658	compound	Rb,protein
R5468	T18658	T18659	nsubjpass	protein,detected
R5469	T18660	T18659	auxpass	was,detected
R5470	T18661	T18659	advmod	also,detected
R5471	T18662	T18659	prep	in,detected
R5472	T18663	T18664	det	the,retina
R5473	T18664	T18662	pobj	retina,in
R5474	T18665	T18664	amod	inner,retina
R5475	T18666	T18667	punct	(,5A
R5476	T18667	T18659	parataxis	5A,detected
R5477	T18668	T18667	compound	Figure,5A
R5478	T18669	T18667	punct	),5A
R5479	T18670	T18659	punct	", ",detected
R5480	T18671	T18659	cc	and,detected
R5481	T18672	T18659	conj	showed,detected
R5482	T18673	T18674	det	a,distribution
R5483	T18674	T18672	dobj	distribution,showed
R5484	T18675	T18674	amod	similar,distribution
R5485	T18676	T18674	prep	as,distribution
R5486	T18677	T18676	pobj	E2f3,as
R5487	T18678	T18672	prep	in,showed
R5488	T18679	T18678	pobj	SACs,in
R5489	T18680	T18681	punct	(,5B
R5490	T18681	T18672	parataxis	5B,showed
R5491	T18682	T18681	compound	Figure,5B
R5492	T18683	T18681	punct	),5B
R5493	T18684	T18672	punct	", ",showed
R5494	T18685	T18672	cc	and,showed
R5495	T18686	T18672	conj	was,showed
R5496	T18687	T18686	advmod	also,was
R5497	T18688	T18686	acomp	present,was
R5498	T18689	T18686	prep	in,was
R5499	T18690	T18691	amod	mature,cells
R5500	T18691	T18689	pobj	cells,in
R5501	T18692	T18691	compound	ganglion,cells
R5502	T18693	T18691	cc	and,cells
R5503	T18694	T18695	compound	Müller,cells
R5504	T18695	T18691	conj	cells,cells
R5505	T18696	T18697	mark	as,reported
R5506	T18697	T18686	advcl	reported,was
R5507	T18698	T18699	punct	[,51
R5508	T18699	T18697	parataxis	51,reported
R5509	T18700	T18699	punct	],51
R5510	T18701	T18659	punct	.,detected
R5511	T18703	T18704	compound	Rb,staining
R5512	T18704	T18705	nsubj	staining,was
R5513	T18706	T18704	prep	in,staining
R5514	T18707	T18708	compound	SAC,processes
R5515	T18708	T18706	pobj	processes,in
R5516	T18709	T18705	acomp	specific,was
R5517	T18710	T18711	mark	as,was
R5518	T18711	T18705	advcl	was,was
R5519	T18712	T18711	nsubj	it,was
R5520	T18713	T18711	acomp	absent,was
R5521	T18714	T18711	prep	in,was
R5522	T18715	T18716	det	the,retina
R5523	T18716	T18714	pobj	retina,in
R5524	T18717	T18716	amod	peripheral,retina
R5525	T18718	T18716	prep	of,retina
R5526	T18719	T18720	nmod	αCre,loxP
R5527	T18720	T18724	compound	loxP,mice
R5528	T18721	T18720	punct	;,loxP
R5529	T18722	T18720	compound	RbloxP,loxP
R5530	T18723	T18720	punct	/,loxP
R5531	T18724	T18718	pobj	mice,of
R5532	T18725	T18726	punct	(,5A
R5533	T18726	T18705	parataxis	5A,was
R5534	T18727	T18726	compound	Figure,5A
R5535	T18728	T18726	punct	),5A
R5536	T18729	T18705	punct	.,was
R5537	T18731	T18732	det	These,data
R5538	T18732	T18733	nsubj	data,suggest
R5539	T18734	T18735	mark	that,colocalize
R5540	T18735	T18733	advcl	colocalize,suggest
R5541	T18736	T18735	nsubj	Rb,colocalize
R5542	T18737	T18736	cc	and,Rb
R5543	T18738	T18736	conj	E2f3,Rb
R5587	T18785	T18786	prep	For,colocalized
R5588	T18787	T18785	pobj	example,For
R5589	T18788	T18786	punct	", ",colocalized
R5590	T18789	T18786	prep	in,colocalized
R5591	T18790	T18791	det	the,amygdala
R5592	T18791	T18789	pobj	amygdala,in
R5593	T18792	T18791	compound	P20,amygdala
R5594	T18793	T18786	punct	", ",colocalized
R5595	T18794	T18786	nsubj	E2f3,colocalized
R5596	T18795	T18786	prep	with,colocalized
R5597	T18796	T18797	det	the,markers
R5598	T18797	T18795	pobj	markers,with
R5599	T18798	T18797	amod	general,markers
R5600	T18799	T18797	amod	neuronal,markers
R5601	T18800	T18797	appos	Mtap2,markers
R5602	T18801	T18800	cc	and,Mtap2
R5603	T18802	T18800	conj	Mecp2,Mtap2
R5604	T18803	T18804	punct	[,52
R5605	T18804	T18797	parataxis	52,markers
R5606	T18805	T18804	punct	],52
R5607	T18806	T18795	punct	", ",with
R5608	T18807	T18795	cc	but,with
R5609	T18808	T18807	neg	not,but
R5610	T18809	T18795	conj	with,with
R5611	T18810	T18809	pobj	Calb2,with
R5612	T18811	T18810	punct	", ",Calb2
R5613	T18812	T18813	dep	which,marks
R5614	T18813	T18810	relcl	marks,Calb2
R5615	T18814	T18815	det	a,subset
R5616	T18815	T18813	dobj	subset,marks
R5617	T18816	T18815	prep	of,subset
R5618	T18817	T18816	pobj	neurons,of
R5619	T18818	T18809	punct	", ",with
R5620	T18819	T18809	cc	or,with
R5621	T18820	T18809	conj	with,with
R5622	T18821	T18822	det	the,marker
R5623	T18822	T18820	pobj	marker,with
R5624	T18823	T18822	amod	glial,marker
R5625	T18824	T18822	appos	Gfap,marker
R5626	T18825	T18826	punct	(,shown
R5627	T18826	T18786	parataxis	shown,colocalized
R5628	T18827	T18826	nsubj	data,shown
R5629	T18828	T18826	neg	not,shown
R5630	T18829	T18826	punct	),shown
R5631	T18830	T18786	punct	.,colocalized
R5632	T18832	T18833	prep	Unlike,coexpressed
R5633	T18834	T18832	prep	in,Unlike
R5634	T18835	T18836	amod	retinal,SACs
R5635	T18836	T18834	pobj	SACs,in
R5636	T18837	T18833	punct	", ",coexpressed
R5637	T18838	T18833	nsubjpass	E2f3,coexpressed
R5638	T18839	T18833	auxpass	was,coexpressed
R5639	T18840	T18833	neg	not,coexpressed
R5640	T18841	T18833	prep	in,coexpressed
R5641	T18842	T18843	nmod	Chat,neurons
R5642	T18843	T18841	pobj	neurons,in
R5643	T18844	T18842	punct	+,Chat
R5644	T18845	T18842	cc	or,Chat
R5645	T18846	T18842	conj	Slc18a3,Chat
R5646	T18847	T18846	punct	+,Slc18a3
R5647	T18848	T18843	amod	cholinergic,neurons
R5648	T18849	T18843	acl	located,neurons
R5649	T18850	T18849	prep	in,located
R5650	T18851	T18852	amod	various,regions
R5651	T18852	T18850	pobj	regions,in
R5652	T18853	T18852	prep	of,regions
R5653	T18854	T18855	det	the,brain
R5654	T18855	T18853	pobj	brain,of
R5655	T18856	T18855	cc	and,brain
R5656	T18857	T18858	amod	spinal,cord
R5657	T18858	T18855	conj	cord,brain
R5658	T18859	T18860	punct	(,shown
R5659	T18860	T18833	parataxis	shown,coexpressed
R5660	T18861	T18860	nsubj	data,shown
R5661	T18862	T18860	neg	not,shown
R5662	T18863	T18860	punct	),shown
R5663	T18864	T18833	punct	.,coexpressed
R5664	T18866	T18867	prep	In,detect
R5665	T18868	T18866	pobj	agreement,In
R5666	T18869	T18867	punct	", ",detect
R5667	T18870	T18867	nsubj	we,detect
R5668	T18871	T18867	aux	could,detect
R5669	T18872	T18867	neg	not,detect
R5670	T18873	T18867	dobj	defects,detect
R5671	T18874	T18873	prep	in,defects
R5672	T18875	T18876	amod	cholinergic,neurons
R5673	T18876	T18874	pobj	neurons,in
R5674	T18877	T18878	compound	Rb,KO
R5675	T18878	T18876	compound	KO,neurons
R5676	T18879	T18876	prep	in,neurons
R5677	T18880	T18881	det	the,forebrain
R5678	T18881	T18879	pobj	forebrain,in
R5679	T18882	T18881	amod	developing,forebrain
R5680	T18883	T18867	punct	", ",detect
R5681	T18884	T18867	cc	but,detect
R5682	T18885	T18886	amod	other,neurons
R5683	T18886	T18889	nsubj	neurons,showed
R5684	T18887	T18888	compound	Rb,KO
R5685	T18888	T18886	compound	KO,neurons
R5686	T18889	T18867	conj	showed,detect
R5687	T18890	T18886	prep	in,neurons
R5688	T18891	T18892	det	this,region
R5689	T18892	T18890	pobj	region,in
R5690	T18893	T18894	compound	differentiation,defects
R5691	T18894	T18889	dobj	defects,showed
R5692	T18895	T18896	dep	that,rescued
R5693	T18896	T18894	relcl	rescued,defects
R5694	T18897	T18896	auxpass	were,rescued
R5695	T18898	T18896	prep	by,rescued
R5696	T18899	T18898	pcomp	deleting,by
R5697	T18900	T18899	dobj	E2f3,deleting
R5698	T18901	T18902	punct	[,53
R5699	T18902	T18889	parataxis	53,showed
R5700	T18903	T18902	punct	],53
R5701	T18904	T18889	punct	.,showed
R5702	T18906	T18907	advmod	Together,suggest
R5703	T18908	T18907	punct	", ",suggest
R5704	T18909	T18910	det	these,results
R5705	T18910	T18907	nsubj	results,suggest
R5706	T18911	T18912	mark	that,is
R5707	T18912	T18907	ccomp	is,suggest
R5708	T18913	T18914	det	the,mechanism
R5709	T18914	T18912	nsubj	mechanism,is
R5710	T18915	T18914	amod	common,mechanism
R5711	T18916	T18917	prep	by,promotes
R5712	T18917	T18914	relcl	promotes,mechanism
R5713	T18918	T18916	pobj	which,by
R5714	T18919	T18917	nsubj	Rb,promotes
R5715	T18920	T18921	amod	neural,differentiation
R5716	T18921	T18917	dobj	differentiation,promotes
R5717	T18922	T18912	prep	through,is
R5718	T18923	T18924	compound	E2f3,inhibition
R5719	T18924	T18922	pobj	inhibition,through
R5720	T18925	T18907	punct	.,suggest
R5721	T20216	T20217	amod	Distinct,Localization
R5722	T20218	T20217	prep	of,Localization
R5723	T20219	T20220	compound	E2f3,Isoforms
R5724	T20220	T20218	pobj	Isoforms,of
R5725	T20222	T20223	mark	As,noted
R5726	T20223	T20224	advcl	noted,was
R5727	T20225	T20223	advmod	above,noted
R5728	T20226	T20224	punct	", ",was
R5729	T20227	T20228	nmod	E2f3,staining
R5730	T20228	T20224	nsubj	staining,was
R5731	T20229	T20227	cc	and,E2f3
R5732	T20230	T20227	conj	Rb,E2f3
R5733	T20231	T20228	prep	in,staining
R5734	T20232	T20231	pobj	SACs,in
R5735	T20233	T20234	preconj	both,nuclear
R5736	T20234	T20224	acomp	nuclear,was
R5737	T20235	T20234	cc	and,nuclear
R5738	T20236	T20234	conj	cytoplasmic,nuclear
R5739	T20237	T20238	punct	(,5A
R5740	T20238	T20224	parataxis	5A,was
R5741	T20239	T20238	compound	Figure,5A
R5742	T20240	T20238	cc	and,5A
R5743	T20241	T20238	conj	5B,5A
R5744	T20242	T20238	punct	),5A
R5745	T20243	T20224	punct	.,was
R5746	T20245	T20246	det	The,antibody
R5747	T20246	T20247	nsubj	antibody,recognizes
R5748	T20248	T20249	dep	that,worked
R5749	T20249	T20246	relcl	worked,antibody
R5750	T20250	T20249	prep	in,worked
R5751	T20251	T20250	pobj	immunostaining,in
R5752	T20252	T20253	det	a,region
R5753	T20253	T20247	dobj	region,recognizes
R5754	T20254	T20255	npadvmod	C,terminal
R5755	T20255	T20253	amod	terminal,region
R5756	T20256	T20255	punct	-,terminal
R5757	T20257	T20247	cc	and,recognizes
R5758	T20258	T20259	advmod	thus,distinguish
R5759	T20259	T20247	conj	distinguish,recognizes
R5760	T20260	T20259	punct	", ",distinguish
R5761	T20261	T20259	aux	does,distinguish
R5762	T20262	T20259	neg	not,distinguish
R5763	T20263	T20264	compound	a,b
R5764	T20264	T20266	compound	b,isoforms
R5765	T20265	T20264	punct	/,b
R5766	T20266	T20259	dobj	isoforms,distinguish
R5767	T20267	T20247	punct	.,recognizes
R5768	T20269	T20270	prep	To,determined
R5769	T20271	T20272	poss	our,knowledge
R5770	T20272	T20269	pobj	knowledge,To
R5771	T20273	T20270	punct	", ",determined
R5772	T20274	T20275	det	the,location
R5773	T20275	T20270	nsubjpass	location,determined
R5774	T20276	T20275	amod	subcellular,location
R5775	T20277	T20275	prep	of,location
R5776	T20278	T20279	compound	E2f3,isoforms
R5777	T20279	T20277	pobj	isoforms,of
R5778	T20280	T20270	aux	has,determined
R5779	T20281	T20270	neg	not,determined
R5780	T20282	T20270	auxpass	been,determined
R5781	T20283	T20270	prep	in,determined
R5782	T20284	T20285	det	any,type
R5783	T20285	T20283	pobj	type,in
R5784	T20286	T20285	compound	cell,type
R5785	T20287	T20270	punct	.,determined
R5786	T20289	T20290	aux	To,verify
R5787	T20290	T20291	advcl	verify,analyzed
R5788	T20292	T20293	det	the,locations
R5789	T20293	T20290	dobj	locations,verify
R5790	T20294	T20293	amod	dual,locations
R5791	T20295	T20293	prep	of,locations
R5792	T20296	T20295	pobj	E2f3,of
R5793	T20297	T20290	cc	and,verify
R5794	T20298	T20299	aux	to,determine
R5795	T20299	T20290	conj	determine,verify
R5796	T20300	T20301	det	which,isoforms
R5797	T20301	T20302	dep	isoforms,were
R5798	T20302	T20299	ccomp	were,determine
R5799	T20303	T20302	acomp	present,were
R5800	T20304	T20302	prep	in,were
R5801	T20305	T20304	pobj	retina,in
R5802	T20306	T20291	punct	", ",analyzed
R5803	T20307	T20291	nsubj	we,analyzed
R5804	T20308	T20309	amod	nuclear,fractions
R5805	T20309	T20291	dobj	fractions,analyzed
R5806	T20310	T20308	cc	and,nuclear
R5807	T20311	T20308	conj	cytoplasmic,nuclear
R5808	T20312	T20291	prep	by,analyzed
R5809	T20313	T20314	compound	Western,blot
R5810	T20314	T20312	pobj	blot,by
R5811	T20315	T20291	prep	at,analyzed
R5812	T20316	T20317	amod	different,times
R5813	T20317	T20315	pobj	times,at
R5814	T20318	T20317	prep	during,times
R5815	T20319	T20318	pobj	development,during
R5816	T20320	T20291	punct	.,analyzed
R5817	T20322	T20323	nsubj	Analysis,detected
R5818	T20324	T20322	prep	with,Analysis
R5819	T20325	T20326	det	the,antibody
R5820	T20326	T20324	pobj	antibody,with
R5821	T20327	T20326	amod	pan-E2f3,antibody
R5822	T20328	T20326	punct	(,antibody
R5823	T20329	T20326	appos	sc,antibody
R5824	T20330	T20329	punct	-,sc
R5825	T20331	T20329	nummod	878,sc
R5826	T20332	T20333	punct	", ",Biotechnology
R5827	T20333	T20326	parataxis	Biotechnology,antibody
R5828	T20334	T20335	compound	Santa,Cruz
R5829	T20335	T20333	compound	Cruz,Biotechnology
R5830	T20336	T20333	punct	),Biotechnology
R5831	T20337	T20338	det	a,species
R5832	T20338	T20323	dobj	species,detected
R5833	T20339	T20340	nummod	55,kD
R5834	T20340	T20338	compound	kD,species
R5835	T20341	T20340	punct	-,kD
R5836	T20342	T20338	compound	E2f3a,species
R5837	T20343	T20338	cc	and,species
R5838	T20344	T20345	det	a,polypeptide
R5839	T20345	T20338	conj	polypeptide,species
R5840	T20346	T20347	nummod	40,kD
R5841	T20347	T20345	compound	kD,polypeptide
R5842	T20348	T20347	punct	-,kD
R5843	T20349	T20345	compound	E2f3b,polypeptide
R5844	T20350	T20351	punct	(,Figure
R5845	T20351	T20323	parataxis	Figure,detected
R5846	T20352	T20351	nummod	6,Figure
R5847	T20353	T20351	punct	),Figure
R5848	T20354	T20323	punct	.,detected
R5849	T20356	T20357	aux	To,confirm
R5850	T20357	T20358	advcl	confirm,exploited
R5851	T20359	T20360	mark	that,was
R5852	T20360	T20357	ccomp	was,confirm
R5853	T20361	T20362	det	the,species
R5854	T20362	T20360	nsubj	species,was
R5855	T20363	T20362	amod	upper,species
R5856	T20364	T20362	prep	in,species
R5857	T20365	T20366	poss	our,lysates
R5858	T20366	T20364	pobj	lysates,in
R5859	T20367	T20366	amod	retinal,lysates
R5860	T20368	T20360	attr	E2f3a,was
R5861	T20369	T20358	punct	", ",exploited
R5862	T20370	T20358	nsubj	we,exploited
R5863	T20371	T20372	amod	novel,mice
R5864	T20372	T20358	dobj	mice,exploited
R5865	T20373	T20374	dep	that,lack
R5866	T20374	T20372	relcl	lack,mice
R5867	T20375	T20376	compound	E2f3,1a
R5868	T20376	T20374	dobj	1a,lack
R5869	T20377	T20376	compound	exon,1a
R5870	T20378	T20374	cc	and,lack
R5871	T20379	T20380	advmod	thus,express
R5872	T20380	T20374	conj	express,lack
R5873	T20381	T20380	dobj	E2f3b,express
R5874	T20382	T20380	advmod	exclusively,express
R5875	T20383	T20384	punct	(,R.
R5876	T20384	T20380	meta	R.,express
R5877	T20385	T20384	nmod	O.,R.
R5878	T20386	T20384	cc	and,R.
R5879	T20387	T20384	conj	G.,R.
R5880	T20388	T20387	nmod	L.,G.
R5881	T20389	T20387	punct	", ",G.
R5882	T20390	T20391	amod	unpublished,data
R5883	T20391	T20387	conj	data,G.
R5884	T20392	T20391	punct	),data
R5885	T20393	T20358	punct	.,exploited
R5886	T20395	T20396	det	The,strategy
R5887	T20396	T20398	nsubjpass	strategy,discussed
R5888	T20397	T20396	compound	genotyping,strategy
R5889	T20399	T20398	auxpass	is,discussed
R5890	T20400	T20398	prep	in,discussed
R5891	T20401	T20400	pobj	detail,in
R5892	T20402	T20398	advmod	later,discussed
R5893	T20403	T20398	cc	and,discussed
R5894	T20404	T20405	auxpass	is,outlined
R5895	T20405	T20398	conj	outlined,discussed
R5896	T20406	T20405	prep	in,outlined
R5897	T20407	T20408	compound	Figure,7A
R5898	T20408	T20406	pobj	7A,in
R5899	T20409	T20398	punct	.,discussed
R5900	T20411	T20412	compound	Western,analysis
R5901	T20412	T20413	nsubj	analysis,confirmed
R5902	T20414	T20415	mark	that,was
R5903	T20415	T20413	ccomp	was,confirmed
R5904	T20416	T20417	det	the,band
R5905	T20417	T20415	nsubj	band,was
R5906	T20418	T20417	amod	upper,band
R5907	T20419	T20415	acomp	absent,was
R5908	T20420	T20415	prep	in,was
R5909	T20421	T20422	nmod	E2f3a,mice
R5910	T20422	T20420	pobj	mice,in
R5911	T20423	T20421	punct	−,E2f3a
R5912	T20424	T20421	punct	/,E2f3a
R5913	T20425	T20421	punct	−,E2f3a
R5914	T20426	T20427	punct	(,S8
R5915	T20427	T20413	parataxis	S8,confirmed
R5916	T20428	T20427	nmod	Figures,S8
R5917	T20429	T20427	nummod	6,S8
R5918	T20430	T20427	cc	and,S8
R5919	T20431	T20427	punct	),S8
R5920	T20432	T20413	punct	.,confirmed
R5921	T20434	T20435	advcl	Consistent,was
R5922	T20436	T20434	prep	with,Consistent
R5923	T20437	T20438	det	the,drop
R5924	T20438	T20436	pobj	drop,with
R5925	T20439	T20438	prep	in,drop
R5926	T20440	T20441	npadvmod	E2f3,expressing
R5927	T20441	T20443	amod	expressing,cells
R5928	T20442	T20441	punct	-,expressing
R5929	T20443	T20439	pobj	cells,in
R5930	T20444	T20438	prep	during,drop
R5931	T20445	T20446	nmod	WT,maturation
R5932	T20446	T20444	pobj	maturation,during
R5933	T20447	T20446	amod	retinal,maturation
R5934	T20448	T20449	punct	(,5A
R5935	T20449	T20438	parataxis	5A,drop
R5936	T20450	T20449	compound	Figure,5A
R5937	T20451	T20449	punct	),5A
R5938	T20452	T20435	punct	", ",was
R5939	T20453	T20454	det	the,amount
R5940	T20454	T20435	nsubj	amount,was
R5941	T20455	T20454	amod	total,amount
R5942	T20456	T20454	prep	of,amount
R5943	T20457	T20456	pobj	E2f3a,of
R5944	T20458	T20435	acomp	less,was
R5945	T20459	T20435	prep	at,was
R5946	T20460	T20459	pobj	P18,at
R5947	T20461	T20435	prep	compared,was
R5948	T20462	T20461	prep	to,compared
R5949	T20463	T20462	pobj	P0,to
R5950	T20464	T20465	punct	(,Figure
R5951	T20465	T20435	parataxis	Figure,was
R5952	T20466	T20465	nummod	6,Figure
R5953	T20467	T20465	punct	),Figure
R5954	T20468	T20435	punct	.,was
R5955	T20470	T20471	nsubj	E2f3b,was
R5956	T20472	T20471	acomp	present,was
R5957	T20473	T20471	prep	in,was
R5958	T20474	T20475	amod	similar,amounts
R5959	T20475	T20473	pobj	amounts,in
R5960	T20476	T20471	prep	at,was
R5961	T20477	T20478	det	both,points
R5962	T20478	T20476	pobj	points,at
R5963	T20479	T20478	compound	time,points
R5964	T20480	T20471	punct	.,was
R5965	T20482	T20483	prep	At,was
R5966	T20484	T20482	pobj	P0,At
R5967	T20485	T20484	cc	and,P0
R5968	T20486	T20484	conj	P18,P0
R5969	T20487	T20483	punct	", ",was
R5970	T20488	T20483	nsubj	E2f3a,was
R5971	T20489	T20483	acomp	present,was
R5972	T20490	T20483	prep	in,was
R5973	T20491	T20492	preconj	both,nuclear
R5974	T20492	T20493	amod	nuclear,fractions
R5975	T20493	T20490	pobj	fractions,in
R5976	T20494	T20492	cc	and,nuclear
R5977	T20495	T20492	conj	cytoplasmic,nuclear
R5978	T20496	T20483	punct	", ",was
R5979	T20497	T20483	cc	but,was
R5980	T20498	T20499	prep	in,was
R5981	T20499	T20483	conj	was,was
R5982	T20500	T20501	amod	marked,contrast
R5983	T20501	T20498	pobj	contrast,in
R5984	T20502	T20499	punct	", ",was
R5985	T20503	T20499	nsubj	E2f3b,was
R5986	T20504	T20505	advmod	exclusively,nuclear
R5987	T20505	T20499	acomp	nuclear,was
R5988	T20506	T20499	prep	at,was
R5989	T20507	T20508	det	both,times
R5990	T20508	T20506	pobj	times,at
R5991	T20509	T20510	punct	(,Figure
R5992	T20510	T20499	parataxis	Figure,was
R5993	T20511	T20510	nummod	6,Figure
R5994	T20512	T20510	punct	),Figure
R5995	T20513	T20499	punct	.,was
R5996	T20515	T20516	nummod	Two,bands
R5997	T20516	T20520	nsubjpass	bands,detected
R5998	T20517	T20518	advmod	closely,migrating
R5999	T20518	T20516	amod	migrating,bands
R6000	T20519	T20516	compound	E2f3a,bands
R6001	T20521	T20520	auxpass	were,detected
R6002	T20522	T20520	punct	", ",detected
R6003	T20523	T20524	advmod	more,clearly
R6004	T20524	T20525	advmod	clearly,evident
R6005	T20525	T20520	advcl	evident,detected
R6006	T20526	T20525	prep	at,evident
R6007	T20527	T20526	pobj	P18,at
R6008	T20528	T20520	punct	", ",detected
R6009	T20529	T20530	prep	of,was
R6010	T20530	T20520	ccomp	was,detected
R6011	T20531	T20529	pobj	which,of
R6012	T20532	T20533	det	the,species
R6013	T20533	T20530	nsubj	species,was
R6014	T20534	T20533	advmod	faster,species
R6015	T20535	T20533	amod	migrating,species
R6016	T20536	T20530	acomp	dominant,was
R6017	T20537	T20530	prep	in,was
R6018	T20538	T20537	amod	nuclear,in
R6019	T20539	T20530	cc	and,was
R6020	T20540	T20541	det	the,species
R6021	T20541	T20543	nsubj	species,was
R6022	T20542	T20541	amod	slower,species
R6023	T20543	T20530	conj	was,was
R6024	T20544	T20543	acomp	dominant,was
R6025	T20545	T20543	prep	in,was
R6026	T20546	T20545	pobj	cytoplasm,in
R6027	T20547	T20548	punct	(,Figure
R6028	T20548	T20543	parataxis	Figure,was
R6029	T20549	T20548	nummod	6,Figure
R6030	T20550	T20548	punct	),Figure
R6031	T20551	T20520	punct	.,detected
R6032	T20553	T20554	det	The,identity
R6033	T20554	T20555	nsubjpass	identity,confirmed
R6034	T20556	T20554	prep	of,identity
R6035	T20557	T20556	pobj	both,of
R6036	T20558	T20554	prep	as,identity
R6037	T20559	T20560	compound	E2f3a,species
R6038	T20560	T20558	pobj	species,as
R6039	T20561	T20555	auxpass	was,confirmed
R6040	T20562	T20555	agent	by,confirmed
R6041	T20563	T20564	poss	their,absence
R6042	T20564	T20562	pobj	absence,by
R6043	T20565	T20564	prep	in,absence
R6044	T20566	T20567	det	the,retina
R6045	T20567	T20565	pobj	retina,in
R6046	T20568	T20567	compound	P18,retina
R6047	T20569	T20570	compound	E2f3a,KO
R6048	T20570	T20567	compound	KO,retina
R6049	T20571	T20572	punct	(,S8
R6050	T20572	T20555	parataxis	S8,confirmed
R6051	T20573	T20572	compound	Figure,S8
R6052	T20574	T20572	punct	),S8
R6053	T20575	T20555	punct	.,confirmed
R6054	T20577	T20578	nsubj	Analysis,showed
R6055	T20579	T20577	prep	of,Analysis
R6056	T20580	T20579	pobj	Pou4f2,of
R6057	T20581	T20580	punct	", ",Pou4f2
R6058	T20582	T20583	det	a,factor
R6059	T20583	T20580	appos	factor,Pou4f2
R6060	T20584	T20583	amod	nuclear,factor
R6061	T20585	T20583	compound	transcription,factor
R6062	T20586	T20583	acl	expressed,factor
R6063	T20587	T20586	prep	in,expressed
R6064	T20588	T20589	compound	ganglion,cells
R6065	T20589	T20587	pobj	cells,in
R6066	T20590	T20578	punct	", ",showed
R6067	T20591	T20592	mark	that,contaminated
R6068	T20592	T20578	ccomp	contaminated,showed
R6069	T20593	T20594	amod	nuclear,proteins
R6070	T20594	T20592	nsubj	proteins,contaminated
R6071	T20595	T20592	aux	had,contaminated
R6072	T20596	T20592	neg	not,contaminated
R6073	T20597	T20598	det	the,fraction
R6074	T20598	T20592	dobj	fraction,contaminated
R6075	T20599	T20598	amod	cytoplasmic,fraction
R6076	T20600	T20578	punct	", ",showed
R6077	T20601	T20578	cc	and,showed
R6078	T20602	T20603	nsubj	analysis,confirmed
R6079	T20603	T20578	conj	confirmed,showed
R6080	T20604	T20602	prep	of,analysis
R6081	T20605	T20604	pobj	Slc18a3,of
R6082	T20606	T20605	punct	", ",Slc18a3
R6083	T20607	T20608	det	a,marker
R6084	T20608	T20605	appos	marker,Slc18a3
R6085	T20609	T20608	amod	cytoplasmic,marker
R6086	T20610	T20608	compound	SAC,marker
R6087	T20611	T20603	punct	", ",confirmed
R6088	T20612	T20613	mark	that,occurred
R6089	T20613	T20603	ccomp	occurred,confirmed
R6090	T20614	T20615	det	the,reverse
R6091	T20615	T20613	nsubj	reverse,occurred
R6092	T20616	T20613	aux	had,occurred
R6093	T20617	T20613	advmod	also,occurred
R6094	T20618	T20613	neg	not,occurred
R6095	T20619	T20620	punct	(,Figure
R6096	T20620	T20613	parataxis	Figure,occurred
R6097	T20621	T20620	nummod	6,Figure
R6098	T20622	T20620	punct	),Figure
R6099	T20623	T20603	punct	.,confirmed
R6100	T20625	T20626	det	These,data
R6101	T20626	T20627	nsubj	data,show
R6102	T20628	T20627	punct	", ",show
R6103	T20629	T20630	prep	to,for
R6104	T20630	T20627	prep	for,show
R6105	T20631	T20632	poss	our,knowledge
R6106	T20632	T20629	pobj	knowledge,to
R6107	T20633	T20634	det	the,time
R6108	T20634	T20630	pobj	time,for
R6109	T20635	T20634	amod	first,time
R6110	T20636	T20627	punct	", ",show
R6111	T20637	T20638	mark	that,exhibit
R6112	T20638	T20627	ccomp	exhibit,show
R6113	T20639	T20638	nsubj	E2f3a,exhibit
R6114	T20640	T20639	cc	and,E2f3a
R6115	T20641	T20639	conj	E2f3b,E2f3a
R6116	T20642	T20643	amod	distinct,patterns
R6117	T20643	T20638	dobj	patterns,exhibit
R6118	T20644	T20643	prep	of,patterns
R6119	T20645	T20646	amod	subcellular,distribution
R6120	T20646	T20644	pobj	distribution,of
R6121	T20647	T20638	punct	", ",exhibit
R6122	T20648	T20638	cc	and,exhibit
R6123	T20649	T20638	conj	raise,exhibit
R6124	T20650	T20651	det	the,possibility
R6125	T20651	T20649	dobj	possibility,raise
R6126	T20652	T20653	mark	that,regulated
R6127	T20653	T20651	acl	regulated,possibility
R6128	T20654	T20655	compound	E2f3a,localization
R6129	T20655	T20653	nsubjpass	localization,regulated
R6130	T20656	T20653	aux	may,regulated
R6131	T20657	T20653	auxpass	be,regulated
R6132	T20658	T20653	agent	by,regulated
R6133	T20659	T20660	advmod	as,yet
R6134	T20660	T20661	advmod	yet,unknown
R6135	T20661	T20662	amod	unknown,modifications
R6156	T20686	T20682	acomp	present,was
R6157	T20687	T20682	prep	in,was
R6158	T20688	T20689	preconj	both,cytoplasm
R6159	T20689	T20687	pobj	cytoplasm,in
R6160	T20690	T20689	det	the,cytoplasm
R6161	T20691	T20689	compound	WT,cytoplasm
R6162	T20692	T20689	cc	and,cytoplasm
R6163	T20693	T20689	conj	nucleus,cytoplasm
R6164	T20694	T20682	prep	at,was
R6165	T20695	T20694	pobj	P0,at
R6166	T20696	T20682	punct	", ",was
R6167	T20697	T20682	cc	but,was
R6168	T20698	T20699	prep	at,was
R6169	T20699	T20682	conj	was,was
R6170	T20700	T20698	pobj	P18,at
R6171	T20701	T20699	punct	", ",was
R6172	T20702	T20703	advmod	when,increased
R6173	T20703	T20699	advcl	increased,was
R6174	T20704	T20705	det	the,levels
R6175	T20705	T20703	nsubj	levels,increased
R6176	T20706	T20705	prep	of,levels
R6177	T20707	T20706	pobj	Rb,of
R6178	T20708	T20703	aux	had,increased
R6179	T20709	T20699	punct	", ",was
R6180	T20710	T20699	nsubj	it,was
R6181	T20711	T20699	advmod	primarily,was
R6182	T20712	T20699	acomp	nuclear,was
R6183	T20713	T20714	punct	(,Figure
R6184	T20714	T20699	parataxis	Figure,was
R6185	T20715	T20714	nummod	6,Figure
R6186	T20716	T20714	punct	),Figure
R6187	T20717	T20699	punct	.,was
R6188	T20719	T20720	det	A,signal
R6189	T20720	T20725	nsubj	signal,was
R6190	T20721	T20722	advmod	very,faint
R6191	T20722	T20720	amod	faint,signal
R6192	T20723	T20720	amod	cytoplasmic,signal
R6193	T20724	T20720	compound	Rb,signal
R6194	T20726	T20725	acomp	evident,was
R6195	T20727	T20725	prep	at,was
R6196	T20728	T20727	pobj	P18,at
R6197	T20729	T20725	punct	", ",was
R6198	T20730	T20731	dep	which,is
R6199	T20731	T20725	advcl	is,was
R6200	T20732	T20731	acomp	consistent,is
R6201	T20733	T20732	prep	with,consistent
R6202	T20734	T20735	compound	Rb,staining
R6203	T20735	T20733	pobj	staining,with
R6204	T20736	T20735	prep	of,staining
R6205	T20737	T20738	compound	SAC,processes
R6206	T20738	T20736	pobj	processes,of
R6207	T20739	T20740	punct	(,5B
R6208	T20740	T20735	parataxis	5B,staining
R6209	T20741	T20740	compound	Figure,5B
R6210	T20742	T20740	punct	),5B
R6211	T20743	T20733	punct	", ",with
R6212	T20744	T20733	cc	and,with
R6213	T20745	T20733	conj	with,with
R6214	T20746	T20747	det	the,proportion
R6215	T20747	T20745	pobj	proportion,with
R6216	T20748	T20749	advmod	very,small
R6217	T20749	T20747	amod	small,proportion
R6218	T20750	T20747	prep	of,proportion
R6219	T20751	T20750	pobj	SACs,of
R6220	T20752	T20747	prep	in,proportion
R6221	T20753	T20754	det	the,retina
R6222	T20754	T20752	pobj	retina,in
R6223	T20755	T20756	punct	[,38
R6224	T20756	T20731	parataxis	38,is
R6225	T20757	T20756	punct	],38
R6226	T20758	T20725	punct	.,was
R6227	T20760	T20761	nsubjpass	E2f1,detected
R6228	T20762	T20761	auxpass	was,detected
R6229	T20763	T20761	advmod	also,detected
R6230	T20764	T20761	prep	in,detected
R6231	T20765	T20766	preconj	both,nuclear
R6232	T20766	T20767	amod	nuclear,fractions
R6233	T20767	T20764	pobj	fractions,in
R6234	T20768	T20766	cc	and,nuclear
R6235	T20769	T20766	conj	cytoplasmic,nuclear
R6236	T20770	T20761	punct	", ",detected
R6237	T20771	T20772	mark	although,was
R6238	T20772	T20761	advcl	was,detected
R6239	T20773	T20772	prep	unlike,was
R6240	T20774	T20773	pobj	E2f3a,unlike
R6241	T20775	T20772	nsubj	it,was
R6242	T20776	T20777	advmod	predominantly,nuclear
R6243	T20777	T20772	acomp	nuclear,was
R6244	T20778	T20779	preconj	both,at
R6245	T20779	T20772	prep	at,was
R6246	T20780	T20779	pobj	P0,at
R6247	T20781	T20780	cc	and,P0
R6248	T20782	T20780	conj	P18,P0
R6249	T20783	T20784	punct	(,Figure
R6250	T20784	T20772	parataxis	Figure,was
R6251	T20785	T20784	nummod	6,Figure
R6252	T20786	T20784	punct	),Figure
R6253	T20787	T20761	punct	.,detected
R6254	T20789	T20790	det	The,partner
R6255	T20790	T20793	nsubj	partner,was
R6256	T20791	T20790	compound	E2f,partner
R6257	T20792	T20790	compound	dimerization,partner
R6258	T20794	T20790	punct	", ",partner
R6259	T20795	T20790	appos	Tfdp1,partner
R6260	T20796	T20790	punct	", ",partner
R6261	T20797	T20798	dep	which,lacks
R6262	T20798	T20790	relcl	lacks,partner
R6263	T20799	T20800	det	a,signal
R6264	T20800	T20798	dobj	signal,lacks
R6265	T20801	T20802	amod	nuclear,localization
R6266	T20802	T20800	compound	localization,signal
R6267	T20803	T20804	punct	[,54
R6268	T20804	T20798	parataxis	54,lacks
R6269	T20805	T20804	punct	],54
R6270	T20806	T20793	punct	", ",was
R6271	T20807	T20808	advmod	primarily,cytoplasmic
R6272	T20808	T20793	acomp	cytoplasmic,was
R6273	T20809	T20793	prep	at,was
R6274	T20810	T20811	preconj	both,P0
R6275	T20811	T20809	pobj	P0,at
R6276	T20812	T20811	cc	and,P0
R6277	T20813	T20811	conj	P18,P0
R6278	T20814	T20793	punct	", ",was
R6279	T20815	T20793	cc	and,was
R6280	T20816	T20817	det	the,inhibitors
R6281	T20817	T20819	nsubj	inhibitors,showed
R6282	T20818	T20817	compound	Cdk,inhibitors
R6283	T20819	T20793	conj	showed,was
R6284	T20820	T20817	appos	Cdkn1a,inhibitors
R6285	T20821	T20820	cc	and,Cdkn1a
R6286	T20822	T20820	conj	Cdkn1b,Cdkn1a
R6287	T20823	T20824	det	a,pattern
R6288	T20824	T20819	dobj	pattern,showed
R6289	T20825	T20824	amod	similar,pattern
R6290	T20826	T20824	prep	of,pattern
R6291	T20827	T20826	pobj	distribution,of
R6292	T20828	T20829	punct	(,Figure
R6293	T20829	T20819	parataxis	Figure,showed
R6294	T20830	T20829	nummod	6,Figure
R6295	T20831	T20829	punct	),Figure
R6296	T20832	T20819	punct	.,showed
R6297	T20834	T20835	advmod	Thus,showed
R6298	T20836	T20835	punct	", ",showed
R6299	T20837	T20835	prep	among,showed
R6300	T20838	T20839	det	the,regulators
R6301	T20839	T20837	pobj	regulators,among
R6302	T20840	T20841	compound	cell,cycle
R6303	T20841	T20839	compound	cycle,regulators
R6304	T20842	T20843	nsubj	we,examined
R6305	T20843	T20839	advcl	examined,regulators
R6306	T20844	T20835	punct	", ",showed
R6307	T20845	T20835	nsubj	most,showed
R6308	T20846	T20847	amod	bivalent,distribution
R6309	T20847	T20835	dobj	distribution,showed
R6310	T20848	T20835	punct	", ",showed
R6311	T20849	T20835	cc	and,showed
R6312	T20850	T20851	nsubj	E2f3b,was
R6313	T20851	T20835	conj	was,showed
R6314	T20852	T20851	acomp	unusual,was
R6315	T20853	T20851	prep	in,was
R6316	T20854	T20855	poss	its,compartmentalization
R6317	T20855	T20853	pobj	compartmentalization,in
R6318	T20856	T20857	advmod	solely,nuclear
R6319	T20857	T20855	amod	nuclear,compartmentalization
R6320	T20858	T20851	punct	.,was
R6321	T21488	T21489	nsubj	Rb,Regulates
R6322	T21490	T21491	compound	SAC,Differentiation
R6323	T21491	T21489	dobj	Differentiation,Regulates
R6324	T21492	T21489	prep	through,Regulates
R6325	T21493	T21492	pobj	E2f3a,through
R6326	T21495	T21496	aux	To,test
R6327	T21496	T21497	advcl	test,exploited
R6328	T21498	T21499	det	which,isoform
R6329	T21499	T21501	dep	isoform,is
R6330	T21500	T21499	compound	E2f3,isoform
R6331	T21501	T21496	ccomp	is,test
R6332	T21502	T21501	acomp	responsible,is
R6333	T21503	T21502	prep	for,responsible
R6334	T21504	T21505	amod	aberrant,differentiation
R6335	T21505	T21503	pobj	differentiation,for
R6336	T21506	T21507	compound	Rb,KO
R6337	T21507	T21505	compound	KO,differentiation
R6338	T21508	T21505	compound	SAC,differentiation
R6339	T21509	T21497	nsubj	we,exploited
R6340	T21510	T21511	nmod	E2f3a,mice
R6341	T21511	T21497	dobj	mice,exploited
R6342	T21512	T21510	punct	−,E2f3a
R6343	T21513	T21510	punct	/,E2f3a
R6344	T21514	T21510	punct	−,E2f3a
R6345	T21515	T21516	punct	(,7A
R6346	T21516	T21497	parataxis	7A,exploited
R6347	T21517	T21516	compound	Figure,7A
R6348	T21518	T21516	punct	),7A
R6349	T21519	T21497	punct	.,exploited
R6350	T21521	T21522	det	The,strategy
R6351	T21522	T21524	nsubjpass	strategy,used
R6352	T21523	T21522	compound	genotyping,strategy
R6353	T21525	T21522	acl	outlined,strategy
R6354	T21526	T21525	prep	in,outlined
R6355	T21527	T21528	compound	Figure,7A
R6356	T21528	T21526	pobj	7A,in
R6357	T21529	T21524	auxpass	was,used
R6358	T21530	T21531	aux	to,distinguish
R6359	T21531	T21524	advcl	distinguish,used
R6360	T21532	T21533	det	the,alleles
R6361	T21533	T21531	dobj	alleles,distinguish
R6362	T21534	T21533	nmod	E2f3a,alleles
R6363	T21535	T21534	punct	", ",E2f3a
R6364	T21536	T21534	conj	WT,E2f3a
R6365	T21537	T21536	punct	", ",WT
R6366	T21538	T21536	cc	and,WT
R6367	T21539	T21536	conj	null,WT
R6368	T21540	T21524	punct	.,used
R6369	T21542	T21543	amod	Reverse,PCR
R6370	T21543	T21545	nsubj	PCR,confirmed
R6371	T21544	T21543	compound	transcriptase,PCR
R6372	T21546	T21543	punct	(,PCR
R6373	T21547	T21548	compound	RT,PCR
R6374	T21548	T21543	appos	PCR,PCR
R6375	T21549	T21548	punct	-,PCR
R6376	T21550	T21545	punct	),confirmed
R6377	T21551	T21552	det	the,presence
R6378	T21552	T21545	dobj	presence,confirmed
R6379	T21553	T21552	prep	of,presence
R6380	T21554	T21555	preconj	both,E2f3a
R6381	T21555	T21556	nmod	E2f3a,species
R6382	T21556	T21553	pobj	species,of
R6383	T21557	T21555	cc	and,E2f3a
R6384	T21558	T21555	conj	E2f3b,E2f3a
R6385	T21559	T21556	compound	RNA,species
R6386	T21560	T21552	prep	in,presence
R6387	T21561	T21562	det	the,retina
R6388	T21562	T21560	pobj	retina,in
R6389	T21563	T21562	amod	developing,retina
R6390	T21564	T21562	compound	WT,retina
R6391	T21565	T21552	punct	", ",presence
R6392	T21566	T21552	cc	and,presence
R6393	T21567	T21568	det	the,absence
R6394	T21568	T21552	conj	absence,presence
R6395	T21569	T21568	amod	specific,absence
R6396	T21570	T21568	prep	of,absence
R6397	T21571	T21572	compound	E2f3a,RNA
R6398	T21572	T21570	pobj	RNA,of
R6399	T21573	T21568	prep	in,absence
R6400	T21574	T21575	det	the,retina
R6401	T21575	T21573	pobj	retina,in
R6402	T21576	T21575	nmod	E2f3a,retina
R6403	T21577	T21576	punct	−,E2f3a
R6404	T21578	T21576	punct	/,E2f3a
R6405	T21579	T21576	punct	−,E2f3a
R6406	T21580	T21581	punct	(,7B
R6407	T21581	T21545	parataxis	7B,confirmed
R6408	T21582	T21581	compound	Figure,7B
R6409	T21583	T21581	punct	),7B
R6410	T21584	T21545	punct	.,confirmed
R6411	T21586	T21587	compound	E2f3a,protein
R6412	T21587	T21588	nsubj	protein,was
R6413	T21589	T21588	acomp	absent,was
R6414	T21590	T21588	prep	in,was
R6415	T21591	T21592	nmod	E2f3a,lysate
R6416	T21592	T21590	pobj	lysate,in
R6417	T21593	T21591	punct	−,E2f3a
R6418	T21594	T21591	punct	/,E2f3a
R6419	T21595	T21591	punct	−,E2f3a
R6420	T21596	T21592	amod	retinal,lysate
R6421	T21597	T21598	punct	(,S8
R6422	T21598	T21588	parataxis	S8,was
R6423	T21599	T21598	nmod	Figures,S8
R6424	T21600	T21598	nummod	6,S8
R6425	T21601	T21598	cc	and,S8
R6426	T21602	T21598	punct	),S8
R6427	T21603	T21588	punct	.,was
R6428	T21605	T21606	advmod	Importantly,were
R6429	T21607	T21606	punct	", ",were
R6430	T21608	T21609	det	the,levels
R6431	T21609	T21606	nsubj	levels,were
R6432	T21610	T21609	prep	of,levels
R6433	T21611	T21612	compound	E2f3b,message
R6434	T21612	T21610	pobj	message,of
R6435	T21613	T21606	acomp	similar,were
R6436	T21614	T21606	prep	in,were
R6437	T21615	T21616	det	the,retina
R6438	T21616	T21614	pobj	retina,in
R6439	T21617	T21618	nmod	Rb,KO
R6440	T21618	T21616	nmod	KO,retina
R6441	T21619	T21618	cc	and,KO
R6442	T21620	T21621	compound	Rb,E2f3a
R6443	T21621	T21623	compound	E2f3a,DKO
R6444	T21622	T21621	punct	/,E2f3a
R6445	T21623	T21618	conj	DKO,KO
R6446	T21624	T21606	punct	", ",were
R6447	T21625	T21606	advcl	ruling,were
R6448	T21626	T21625	prt	out,ruling
R6449	T21627	T21628	det	the,possibility
R6450	T21628	T21625	dobj	possibility,ruling
R6451	T21629	T21630	mark	that,were
R6452	T21630	T21628	acl	were,possibility
R6453	T21631	T21632	det	any,effects
R6454	T21632	T21630	nsubj	effects,were
R6455	T21633	T21632	prep	of,effects
R6456	T21634	T21635	compound	E2f3a,deletion
R6457	T21635	T21633	pobj	deletion,of
R6458	T21636	T21637	nsubj	we,observe
R6459	T21637	T21632	advcl	observe,effects
R6460	T21638	T21637	aux	might,observe
R6461	T21639	T21630	prep	due,were
R6462	T21640	T21639	pcomp	to,due
R6463	T21641	T21642	amod	down,regulation
R6464	T21642	T21639	pobj	regulation,due
R6465	T21643	T21642	punct	-,regulation
R6466	T21644	T21642	prep	of,regulation
R6467	T21645	T21644	pobj	E2f3b,of
R6468	T21646	T21647	punct	(,7C
R6469	T21647	T21630	parataxis	7C,were
R6470	T21648	T21647	compound	Figure,7C
R6471	T21649	T21647	punct	),7C
R6472	T21650	T21606	punct	.,were
R6473	T21652	T21653	advmod	Also,were
R6474	T21654	T21653	punct	", ",were
R6475	T21655	T21656	det	the,levels
R6476	T21656	T21653	nsubj	levels,were
R6477	T21657	T21656	prep	of,levels
R6478	T21658	T21659	amod	other,E2fs
R6479	T21659	T21657	pobj	E2fs,of
R6480	T21660	T21661	det	the,same
R6481	T21661	T21653	attr	same,were
R6482	T21662	T21661	prep	in,same
R6483	T21663	T21664	det	the,retina
R6484	T21664	T21662	pobj	retina,in
R6485	T21665	T21666	nmod	Rb,KO
R6486	T21666	T21664	nmod	KO,retina
R6487	T21667	T21666	punct	", ",KO
R6488	T21668	T21669	compound	Rb,E2f3
R6489	T21669	T21671	compound	E2f3,DKO
R6490	T21670	T21669	punct	/,E2f3
R6491	T21671	T21666	conj	DKO,KO
R6492	T21672	T21671	punct	", ",DKO
R6493	T21673	T21671	cc	and,DKO
R6494	T21674	T21675	compound	Rb,E2f3a
R6495	T21675	T21677	compound	E2f3a,DKO
R6496	T21676	T21675	punct	/,E2f3a
R6497	T21677	T21671	conj	DKO,DKO
R6498	T21678	T21653	punct	", ",were
R6499	T21679	T21653	advcl	ruling,were
R6500	T21680	T21679	prt	out,ruling
R6501	T21681	T21682	det	any,effects
R6502	T21682	T21679	dobj	effects,ruling
R6503	T21683	T21684	advmod	cross,regulatory
R6504	T21684	T21682	amod	regulatory,effects
R6505	T21685	T21684	punct	-,regulatory
R6506	T21686	T21687	punct	(,7C
R6507	T21687	T21653	parataxis	7C,were
R6508	T21688	T21687	compound	Figure,7C
R6509	T21689	T21687	punct	),7C
R6510	T21690	T21691	punct	[,55
R6511	T21691	T21653	parataxis	55,were
R6512	T21692	T21691	punct	],55
R6513	T21693	T21653	punct	.,were
R6514	T21695	T21696	nsubj	E2f3a,trigger
R6515	T21697	T21696	aux	can,trigger
R6516	T21698	T21699	compound	cell,cycle
R6517	T21699	T21700	compound	cycle,induction
R6518	T21700	T21696	dobj	induction,trigger
R6519	T21701	T21696	punct	", ",trigger
R6520	T21702	T21696	cc	but,trigger
R6521	T21703	T21704	mark	because,linked
R6522	T21704	T21709	advcl	linked,suspected
R6523	T21705	T21706	compound	SAC,defects
R6524	T21706	T21704	nsubjpass	defects,linked
R6525	T21707	T21704	auxpass	are,linked
R6526	T21708	T21704	neg	not,linked
R6527	T21709	T21696	conj	suspected,trigger
R6528	T21710	T21704	prep	to,linked
R6529	T21711	T21712	compound	cell,cycle
R6530	T21712	T21713	compound	cycle,perturbation
R6531	T21713	T21710	pobj	perturbation,to
R6532	T21714	T21715	punct	(,3A
R6533	T21715	T21704	parataxis	3A,linked
R6534	T21716	T21715	compound	Figures,3A
R6535	T21717	T21715	cc	and,3A
R6536	T21718	T21715	conj	4,3A
R6537	T21719	T21715	punct	),3A
R6538	T21720	T21704	punct	", ",linked
R6539	T21721	T21704	cc	and,linked
R6540	T21722	T21704	conj	in,linked
R6541	T21723	T21722	pobj	view,in
R6542	T21724	T21723	prep	of,view
R6543	T21725	T21726	det	the,association
R6544	T21726	T21724	pobj	association,of
R6545	T21727	T21726	amod	predominant,association
R6546	T21728	T21726	prep	between,association
R6547	T21729	T21728	pobj	E2f3b,between
R6548	T21730	T21729	cc	and,E2f3b
R6549	T21731	T21729	conj	Rb,E2f3b
R6550	T21732	T21726	prep	in,association
R6551	T21733	T21734	amod	quiescent,cells
R6552	T21734	T21732	pobj	cells,in
R6553	T21735	T21736	punct	[,19
R6554	T21736	T21726	parataxis	19,association
R6555	T21737	T21736	nummod	16,19
R6556	T21738	T21736	punct	",",19
R6557	T21739	T21736	punct	],19
R6558	T21740	T21709	punct	", ",suspected
R6559	T21741	T21709	nsubj	we,suspected
R6560	T21742	T21743	mark	that,perturb
R6561	T21743	T21709	ccomp	perturb,suspected
R6562	T21744	T21743	nsubj	E2f3b,perturb
R6563	T21745	T21743	aux	may,perturb
R6564	T21746	T21743	dobj	differentiation,perturb
R6565	T21747	T21743	prep	in,perturb
R6566	T21748	T21749	compound	Rb,KO
R6567	T21749	T21750	compound	KO,SACs
R6568	T21750	T21747	pobj	SACs,in
R6569	T21751	T21709	punct	.,suspected
R6570	T21753	T21754	advmod	Unexpectedly,suppressed
R6571	T21755	T21754	punct	", ",suppressed
R6572	T21756	T21754	advmod	however,suppressed
R6573	T21757	T21754	punct	", ",suppressed
R6574	T21758	T21759	compound	E2f3a,deletion
R6575	T21759	T21754	nsubj	deletion,suppressed
R6576	T21760	T21761	det	the,defect
R6577	T21761	T21754	dobj	defect,suppressed
R6578	T21762	T21763	compound	Rb,KO
R6579	T21763	T21761	compound	KO,defect
R6580	T21764	T21761	compound	SAC,defect
R6581	T21765	T21766	punct	(,7D
R6582	T21766	T21754	parataxis	7D,suppressed
R6583	T21767	T21766	compound	Figure,7D
R6584	T21768	T21766	punct	),7D
R6585	T21769	T21754	punct	.,suppressed
R6586	T21771	T21772	advmod	Thus,is
R6587	T21773	T21772	punct	", ",is
R6588	T21774	T21772	advcl	separate,is
R6589	T21775	T21774	prep	from,separate
R6590	T21776	T21777	poss	its,role
R6591	T21777	T21775	pobj	role,from
R6592	T21778	T21777	prep	in,role
R6593	T21779	T21780	compound	cell,cycle
R6594	T21780	T21781	compound	cycle,control
R6595	T21781	T21778	pobj	control,in
R6596	T21782	T21772	punct	", ",is
R6597	T21783	T21784	compound	Rb,regulation
R6598	T21784	T21772	nsubj	regulation,is
R6599	T21785	T21784	prep	of,regulation
R6600	T21786	T21785	pobj	E2f3a,of
R6601	T21787	T21772	acomp	critical,is
R6602	T21788	T21789	aux	to,ensure
R6603	T21789	T21772	advcl	ensure,is
R6604	T21790	T21791	amod	proper,differentiation
R6605	T21791	T21789	dobj	differentiation,ensure
R6606	T21792	T21791	amod	neuronal,differentiation
R6607	T21793	T21772	punct	.,is
R6616	T23003	T23004	nsubj	Rb,Controls
R6617	T23005	T23006	amod	Retinal,Cell
R6618	T23006	T23004	dobj	Cell,Controls
R6619	T23007	T23006	appos	Division,Cell
R6620	T23008	T23007	cc	and,Division
R6621	T23009	T23007	conj	Death,Division
R6622	T23010	T23004	prep	through,Controls
R6623	T23011	T23010	pobj	E2f1,through
R6624	T23013	T23014	nsubj	Work,showed
R6625	T23015	T23013	prep	in,Work
R6626	T23016	T23017	det	the,1990s
R6627	T23017	T23015	pobj	1990s,in
R6628	T23018	T23017	amod	early,1990s
R6629	T23019	T23020	mark	that,triggers
R6630	T23020	T23014	ccomp	triggers,showed
R6631	T23021	T23022	compound	Rb,loss
R6632	T23022	T23020	nsubj	loss,triggers
R6633	T23023	T23020	dobj	defects,triggers
R6634	T23024	T23023	prep	in,defects
R6635	T23025	T23026	amod	neuronal,exit
R6636	T23026	T23024	pobj	exit,in
R6637	T23027	T23028	compound	cell,cycle
R6638	T23028	T23026	compound	cycle,exit
R6639	T23029	T23026	punct	", ",exit
R6640	T23030	T23026	conj	survival,exit
R6641	T23031	T23030	punct	", ",survival
R6642	T23032	T23030	cc	and,survival
R6643	T23033	T23030	conj	differentiation,survival
R6644	T23034	T23035	punct	[,26
R6645	T23035	T23020	parataxis	26,triggers
R6646	T23036	T23037	punct	–,28
R6647	T23037	T23035	prep	28,26
R6648	T23038	T23035	punct	],26
R6649	T23039	T23014	punct	.,showed
R6650	T23041	T23042	nsubj	Much,is
R6651	T23043	T23041	prep	of,Much
R6652	T23044	T23045	det	the,death
R6653	T23045	T23043	pobj	death,of
R6654	T23046	T23047	det	an,consequence
R6655	T23047	T23042	attr	consequence,is
R6656	T23048	T23047	amod	indirect,consequence
R6657	T23049	T23047	prep	of,consequence
R6658	T23050	T23051	amod	probable,hypoxia
R6659	T23051	T23049	pobj	hypoxia,of
R6660	T23052	T23051	acl	linked,hypoxia
R6661	T23053	T23052	prep	to,linked
R6662	T23054	T23055	amod	placental,defects
R6663	T23055	T23053	pobj	defects,to
R6664	T23056	T23057	punct	[,12
R6665	T23057	T23052	parataxis	12,linked
R6666	T23058	T23059	punct	–,14
R6667	T23059	T23057	prep	14,12
R6668	T23060	T23057	punct	],12
R6669	T23061	T23042	punct	.,is
R6670	T23063	T23064	advmod	However,reveal
R6671	T23065	T23064	punct	", ",reveal
R6672	T23066	T23067	amod	targeted,KO
R6673	T23067	T23068	nmod	KO,studies
R6674	T23068	T23064	nsubj	studies,reveal
R6675	T23069	T23067	cc	and,KO
R6676	T23070	T23067	conj	chimeric,KO
R6677	T23071	T23072	mark	that,promotes
R6678	T23072	T23064	ccomp	promotes,reveal
R6679	T23073	T23072	nsubj	Rb,promotes
R6680	T23074	T23072	advmod	autonomously,promotes
R6681	T23075	T23076	compound	cell,cycle
R6682	T23076	T23077	compound	cycle,exit
R6683	T23077	T23072	dobj	exit,promotes
R6684	T23078	T23072	prep	in,promotes
R6685	T23079	T23080	amod	newborn,neurons
R6686	T23080	T23078	pobj	neurons,in
R6687	T23081	T23072	punct	", ",promotes
R6688	T23082	T23072	cc	and,promotes
R6689	T23083	T23084	auxpass	is,required
R6690	T23084	T23072	conj	required,promotes
R6691	T23085	T23084	prep	for,required
R6692	T23086	T23085	pobj	survival,for
R6693	T23087	T23086	prep	of,survival
R6694	T23088	T23089	det	a,subset
R6695	T23089	T23087	pobj	subset,of
R6696	T23090	T23089	prep	of,subset
R6697	T23091	T23090	pobj	neurons,of
R6698	T23092	T23084	punct	", ",required
R6699	T23093	T23094	advmod	particularly,in
R6700	T23094	T23084	prep	in,required
R6701	T23095	T23096	det	the,retina
R6702	T23096	T23094	pobj	retina,in
R6703	T23097	T23098	punct	[,2
R6704	T23098	T23064	parataxis	2,reveal
R6705	T23099	T23098	punct	",",2
R6706	T23100	T23098	appos	3,2
R6707	T23101	T23098	punct	",",2
R6708	T23102	T23098	appos	13,2
R6709	T23103	T23098	punct	",",2
R6710	T23104	T23098	appos	14,2
R6711	T23105	T23098	punct	",",2
R6712	T23106	T23098	appos	56,2
R6713	T23107	T23108	punct	–,59
R6714	T23108	T23106	prep	59,56
R6715	T23109	T23098	punct	],2
R6716	T23110	T23064	punct	.,reveal
R6717	T23112	T23113	advmod	However,obscured
R6718	T23114	T23113	punct	", ",obscured
R6719	T23115	T23116	mark	whether,regulates
R6720	T23116	T23113	csubjpass	regulates,obscured
R6721	T23117	T23116	nsubj	Rb,regulates
R6722	T23118	T23116	advmod	also,regulates
R6723	T23119	T23116	dobj	differentiation,regulates
R6724	T23120	T23113	auxpass	is,obscured
R6725	T23121	T23113	agent	by,obscured
R6726	T23122	T23123	advmod	potentially,indirect
R6727	T23123	T23124	amod	indirect,effects
R6728	T23124	T23121	pobj	effects,by
R6729	T23125	T23124	prep	of,effects
R6730	T23126	T23127	amod	ectopic,division
R6731	T23127	T23125	pobj	division,of
R6732	T23128	T23127	cc	and,division
R6733	T23129	T23127	conj	death,division
R6734	T23130	T23113	punct	.,obscured
R6735	T23132	T23133	advmod	Moreover,elucidated
R6736	T23134	T23133	punct	", ",elucidated
R6737	T23135	T23136	det	a,mechanism
R6738	T23136	T23133	nsubjpass	mechanism,elucidated
R6739	T23137	T23138	prep	though,regulate
R6740	T23138	T23136	relcl	regulate,mechanism
R6741	T23139	T23137	pobj	which,though
R6742	T23140	T23138	nsubj	Rb,regulate
R6743	T23141	T23138	aux	may,regulate
R6744	T23142	T23143	amod	neuronal,maturation
R6745	T23143	T23138	dobj	maturation,regulate
R6746	T23144	T23133	aux	has,elucidated
R6747	T23145	T23133	neg	not,elucidated
R6748	T23146	T23133	auxpass	been,elucidated
R6749	T23147	T23133	punct	.,elucidated
R6750	T23149	T23150	advmod	Here,rescued
R6751	T23151	T23150	punct	", ",rescued
R6752	T23152	T23150	csubj	deleting,rescued
R6753	T23153	T23152	dobj	E2f1,deleting
R6754	T23154	T23150	advmod	specifically,rescued
R6755	T23155	T23156	amod	ectopic,division
R6756	T23156	T23150	dobj	division,rescued
R6757	T23157	T23156	cc	and,division
R6758	T23158	T23156	conj	death,division
R6759	T23159	T23150	prep	in,rescued
R6760	T23160	T23161	det	the,retina
R6761	T23161	T23159	pobj	retina,in
R6762	T23162	T23163	compound	Rb,KO
R6763	T23163	T23161	compound	KO,retina
R6764	T23164	T23150	punct	.,rescued
R6765	T23166	T23167	advmod	Importantly,differentiated
R6766	T23168	T23167	punct	", ",differentiated
R6767	T23169	T23170	amod	major,neurons
R6768	T23170	T23167	nsubj	neurons,differentiated
R6769	T23171	T23172	compound	Rb,E2f1
R6770	T23172	T23174	compound	E2f1,DKO
R6771	T23173	T23172	punct	/,E2f1
R6772	T23174	T23170	compound	DKO,neurons
R6773	T23175	T23167	advmod	normally,differentiated
R6774	T23176	T23167	punct	", ",differentiated
R6775	T23177	T23167	cc	and,differentiated
R6776	T23178	T23179	nsubj	ERGs,revealed
R6777	T23179	T23167	conj	revealed,differentiated
R6778	T23180	T23181	det	the,rescue
R6779	T23181	T23179	dobj	rescue,revealed
R6780	T23182	T23181	prep	of,rescue
R6781	T23183	T23184	npadvmod	rod,mediated
R6782	T23184	T23189	amod	mediated,function
R6783	T23185	T23183	punct	-,rod
R6784	T23186	T23183	cc	and,rod
R6785	T23187	T23183	conj	cone,rod
R6786	T23188	T23184	punct	-,mediated
R6787	T23189	T23182	pobj	function,of
R6788	T23190	T23179	punct	", ",revealed
R6789	T23191	T23179	advcl	implicating,revealed
R6790	T23192	T23193	det	a,flow
R6791	T23193	T23191	dobj	flow,implicating
R6792	T23194	T23193	amod	regular,flow
R6793	T23195	T23193	compound	signal,flow
R6794	T23196	T23193	prep	from,flow
R6795	T23197	T23196	pobj	photoreceptors,from
R6796	T23198	T23193	prep	to,flow
R6797	T23199	T23200	amod	bipolar,cells
R6798	T23200	T23198	pobj	cells,to
R6799	T23201	T23199	cc	and,bipolar
R6800	T23202	T23199	conj	amacrine,bipolar
R6801	T23203	T23179	punct	.,revealed
R6802	T23205	T23206	nmod	Division,genes
R6803	T23206	T23209	nsubjpass	genes,induced
R6804	T23207	T23205	cc	and,Division
R6805	T23208	T23205	conj	death,Division
R6806	T23210	T23209	auxpass	were,induced
R6807	T23211	T23209	prep	in,induced
R6808	T23212	T23213	compound	Rb,KO
R6809	T23213	T23214	compound	KO,cells
R6810	T23214	T23211	pobj	cells,in
R6811	T23215	T23209	punct	", ",induced
R6812	T23216	T23209	cc	and,induced
R6813	T23217	T23218	csubj	deleting,reversed
R6814	T23218	T23209	conj	reversed,induced
R6815	T23219	T23217	dobj	E2f1,deleting
R6816	T23220	T23219	punct	", ",E2f1
R6817	T23221	T23219	cc	but,E2f1
R6818	T23222	T23221	neg	not,but
R6819	T23223	T23219	conj	E2f2,E2f1
R6820	T23224	T23223	cc	or,E2f2
R6821	T23225	T23223	conj	E2f3,E2f2
R6822	T23226	T23218	punct	", ",reversed
R6823	T23227	T23228	det	these,events
R6824	T23228	T23218	dobj	events,reversed
R6825	T23229	T23228	amod	molecular,events
R6826	T23230	T23218	punct	.,reversed
R6827	T23232	T23233	nsubj	E2f1,regulate
R6828	T23234	T23233	aux	may,regulate
R6829	T23235	T23233	advmod	also,regulate
R6830	T23236	T23237	compound	differentiation,targets
R6831	T23237	T23233	dobj	targets,regulate
R6832	T23238	T23233	punct	", ",regulate
R6833	T23239	T23233	cc	but,regulate
R6834	T23240	T23241	mark	whether,contributes
R6835	T23241	T23243	csubj	contributes,is
R6836	T23242	T23241	nsubj	this,contributes
R6837	T23243	T23233	conj	is,regulate
R6838	T23244	T23241	prep	to,contributes
R6839	T23245	T23244	pobj	defects,to
R6840	T23246	T23245	prep	in,defects
R6841	T23247	T23248	amod	retinal,cell
R6842	T23248	T23249	compound	cell,maturation
R6843	T23249	T23246	pobj	maturation,in
R6844	T23250	T23243	acomp	impossible,is
R6845	T23251	T23252	aux	to,separate
R6846	T23252	T23250	xcomp	separate,impossible
R6847	T23253	T23252	prep	from,separate
R6848	T23254	T23255	advmod	potentially,indirect
R6849	T23255	T23256	amod	indirect,consequences
R6850	T23256	T23253	pobj	consequences,from
R6851	T23257	T23256	prep	of,consequences
R6852	T23258	T23259	amod	deregulated,division
R6853	T23259	T23257	pobj	division,of
R6854	T23260	T23259	cc	and,division
R6855	T23261	T23259	conj	death,division
R6856	T23262	T23243	punct	.,is
R6857	T23264	T23265	prep	In,is
R6858	T23266	T23267	det	any,case
R6859	T23267	T23264	pobj	case,In
R6860	T23268	T23265	punct	", ",is
R6861	T23269	T23265	nsubj	it,is
R6862	T23270	T23265	acomp	clear,is
R6863	T23271	T23272	mark	that,function
R6864	T23272	T23265	ccomp	function,is
R6865	T23273	T23272	prep	in,function
R6866	T23274	T23275	amod	most,cells
R6867	T23275	T23273	pobj	cells,in
R6868	T23276	T23275	amod	retinal,cells
R6869	T23277	T23275	punct	", ",cells
R6870	T23278	T23275	prep	including,cells
R6871	T23279	T23278	pobj	photoreceptors,including
R6872	T23280	T23281	punct	[,29
R6873	T23281	T23275	parataxis	29,cells
R6874	T23282	T23281	punct	],29
R6875	T23283	T23272	punct	", ",function
R6876	T23284	T23285	compound	transcription,factors
R6877	T23285	T23272	nsubj	factors,function
R6878	T23286	T23287	dep	that,promote
R6879	T23287	T23285	relcl	promote,factors
R6880	T23288	T23287	dobj	differentiation,promote
R6881	T23289	T23272	advmod	independently,function
R6882	T23290	T23289	prep	of,independently
R6883	T23291	T23290	pobj	Rb,of
R6884	T23292	T23265	punct	.,is
R6885	T23294	T23295	nsubj	We,found
R6886	T23296	T23295	aux	have,found
R6887	T23297	T23295	advmod	also,found
R6888	T23298	T23299	mark	that,rescues
R6889	T23299	T23295	ccomp	rescues,found
R6890	T23300	T23301	compound	E2f1,deletion
R6891	T23301	T23299	nsubj	deletion,rescues
R6892	T23302	T23303	npadvmod	cell,autonomous
R6893	T23303	T23305	amod	autonomous,division
R6894	T23304	T23303	punct	-,autonomous
R6895	T23305	T23299	dobj	division,rescues
R6896	T23306	T23305	amod	ectopic,division
R6897	T23307	T23305	punct	", ",division
R6898	T23308	T23305	conj	death,division
R6899	T23309	T23308	punct	", ",death
R6900	T23310	T23308	cc	and,death
R6901	T23311	T23312	compound	differentiation,defects
R6902	T23312	T23308	conj	defects,death
R6903	T23313	T23299	prep	in,rescues
R6904	T23314	T23315	amod	sporadic,clones
R6905	T23315	T23313	pobj	clones,in
R6906	T23316	T23317	compound	Rb,KO
R6907	T23317	T23315	compound	KO,clones
R6908	T23318	T23315	acl	generated,clones
R6909	T23319	T23318	advcl	using,generated
R6910	T23320	T23321	det	a,vector
R6911	T23321	T23319	dobj	vector,using
R6912	T23322	T23323	compound	Cre,retrovirus
R6913	T23323	T23321	compound	retrovirus,vector
R6914	T23324	T23325	punct	(,M.
R6915	T23325	T23319	meta	M.,using
R6916	T23326	T23325	nmod	P.,M.
R6917	T23327	T23325	cc	and,M.
R6918	T23328	T23325	conj	R.,M.
R6919	T23329	T23328	nmod	B.,R.
R6920	T23330	T23328	punct	", ",R.
R6921	T23331	T23332	amod	unpublished,data
R6922	T23332	T23328	conj	data,R.
R6923	T23333	T23332	punct	),data
R6924	T23334	T23295	punct	.,found
R6925	T23336	T23337	det	These,data
R6926	T23337	T23338	nsubj	data,are
R6927	T23339	T23338	acomp	consistent,are
R6928	T23340	T23339	prep	with,consistent
R6929	T23341	T23342	det	the,observation
R6930	T23342	T23340	pobj	observation,with
R6931	T23343	T23344	mark	that,drives
R6932	T23344	T23342	acl	drives,observation
R6933	T23345	T23346	compound	E2f1,overexpression
R6934	T23346	T23344	nsubj	overexpression,drives
R6935	T23347	T23346	prep	in,overexpression
R6936	T23348	T23349	amod	newborn,photoreceptors
R6937	T23349	T23347	pobj	photoreceptors,in
R6938	T23350	T23351	amod	ectopic,division
R6939	T23351	T23344	dobj	division,drives
R6940	T23352	T23351	cc	and,division
R6941	T23353	T23351	conj	apoptosis,division
R6942	T23354	T23355	punct	[,60
R6943	T23355	T23344	parataxis	60,drives
R6944	T23356	T23355	punct	],60
R6945	T23357	T23338	punct	", ",are
R6946	T23358	T23338	cc	and,are
R6947	T23359	T23338	conj	add,are
R6948	T23360	T23359	prep	to,add
R6949	T23361	T23362	det	the,evidence
R6950	T23362	T23360	pobj	evidence,to
R6951	T23363	T23362	amod	growing,evidence
R6952	T23364	T23362	acl	indicating,evidence
R6953	T23365	T23366	mark	that,is
R6954	T23366	T23364	ccomp	is,indicating
R6955	T23367	T23366	nsubj	E2f1,is
R6956	T23368	T23369	det	the,member
R6957	T23369	T23366	attr	member,is
R6958	T23370	T23369	amod	major,member
R6959	T23371	T23370	punct	", ",major
R6960	T23372	T23370	cc	and,major
R6961	T23373	T23374	advmod	perhaps,only
R6962	T23374	T23370	conj	only,major
R6963	T23375	T23369	punct	", ",member
R6964	T23376	T23369	prep	of,member
R6965	T23377	T23378	det	the,E2fs
R6966	T23378	T23376	pobj	E2fs,of
R6967	T23379	T23378	nummod	three,E2fs
R6968	T23380	T23378	amod	activating,E2fs
R6969	T23381	T23378	acl	required,E2fs
R6970	T23382	T23383	aux	to,induce
R6971	T23383	T23381	xcomp	induce,required
R6972	T23384	T23383	dobj	apoptosis,induce
R6973	T23385	T23383	prep	in,induce
R6974	T23386	T23387	compound	Rb,KO
R6975	T23387	T23388	compound	KO,cells
R6976	T23388	T23385	pobj	cells,in
R6977	T23389	T23390	punct	[,15
R6978	T23390	T23359	parataxis	15,add
R6979	T23391	T23390	nummod	10,15
R6980	T23392	T23390	punct	",",15
R6981	T23393	T23390	punct	],15
R6982	T23394	T23338	punct	.,are
R6983	T23396	T23397	advmod	Thus,promotes
R6984	T23398	T23397	punct	", ",promotes
R6985	T23399	T23400	amod	deregulated,activity
R6986	T23400	T23397	nsubj	activity,promotes
R6987	T23401	T23400	compound	E2f1,activity
R6988	T23402	T23400	prep	in,activity
R6989	T23403	T23404	det	the,retina
R6990	T23404	T23402	pobj	retina,in
R6991	T23405	T23397	punct	", ",promotes
R6992	T23406	T23407	mark	whether,resulting
R6993	T23407	T23397	advcl	resulting,promotes
R6994	T23408	T23407	prep	from,resulting
R6995	T23409	T23410	det	the,inactivation
R6996	T23410	T23408	pobj	inactivation,from
R6997	T23411	T23410	prep	of,inactivation
R6998	T23412	T23411	pobj	Rb,of
R6999	T23413	T23408	cc	or,from
R7000	T23414	T23408	conj	from,from
R7001	T23415	T23414	pobj	overexpression,from
R7002	T23416	T23397	punct	", ",promotes
R7003	T23417	T23418	amod	unscheduled,division
R7004	T23418	T23397	dobj	division,promotes
R7005	T23419	T23418	compound	cell,division
R7006	T23420	T23397	cc	and,promotes
R7007	T23421	T23397	conj	triggers,promotes
R7008	T23422	T23421	dobj	apoptosis,triggers
R7009	T23423	T23421	prep	in,triggers
R7010	T23424	T23425	amod	susceptible,RTCs
R7011	T23425	T23423	pobj	RTCs,in
R7012	T23426	T23397	punct	.,promotes
R7013	T23428	T23429	nsubj	E2f1,be
R7014	T23430	T23428	punct	", ",E2f1
R7015	T23431	T23432	advmod	rather,than
R7016	T23432	T23428	cc	than,E2f1
R7017	T23433	T23434	amod	other,E2fs
R7018	T23434	T23428	conj	E2fs,E2f1
R7019	T23435	T23429	punct	", ",be
R7020	T23436	T23429	aux	may,be
R7021	T23437	T23438	det	a,target
R7022	T23438	T23429	attr	target,be
R7023	T23439	T23438	amod	potential,target
R7024	T23440	T23438	prep	for,target
R7025	T23441	T23442	amod	novel,therapeutics
R7026	T23442	T23440	pobj	therapeutics,for
R7027	T23443	T23444	aux	to,prevent
R7028	T23444	T23442	advcl	prevent,therapeutics
R7029	T23445	T23444	dobj	retinoblastoma,prevent
R7030	T23446	T23444	prep	in,prevent
R7031	T23447	T23448	nmod	RB1,humans
R7032	T23448	T23446	pobj	humans,in
R7033	T23449	T23447	punct	+,RB1
R7034	T23450	T23447	punct	/,RB1
R7035	T23451	T23447	punct	−,RB1
R7036	T23452	T23429	punct	.,be
R7037	T23454	T23455	poss	Our,studies
R7038	T23455	T23457	nsubj	studies,revealed
R7039	T23456	T23455	compound	ERG,studies
R7040	T23458	T23457	dobj	rescue,revealed
R7041	T23459	T23458	prep	of,rescue
R7042	T23460	T23461	det	the,system
R7043	T23461	T23459	pobj	system,of
R7044	T23462	T23463	nmod	Rb,KO
R7045	T23463	T23461	nmod	KO,system
R7046	T23464	T23465	npadvmod	rod,bipolar
R7047	T23465	T23461	amod	bipolar,system
R7048	T23466	T23465	punct	–,bipolar
R7049	T23467	T23458	punct	", ",rescue
R7050	T23468	T23458	cc	and,rescue
R7051	T23469	T23470	advmod	almost,complete
R7052	T23470	T23471	amod	complete,restoration
R7053	T23471	T23458	conj	restoration,rescue
R7054	T23472	T23471	prep	of,restoration
R7055	T23473	T23474	det	the,system
R7056	T23474	T23472	pobj	system,of
R7057	T23475	T23476	npadvmod	cone,bipolar
R7058	T23476	T23474	amod	bipolar,system
R7059	T23477	T23476	punct	–,bipolar
R7060	T23478	T23458	prep	following,rescue
R7061	T23479	T23480	compound	E2f1,deletion
R7062	T23480	T23478	pobj	deletion,following
R7063	T23481	T23457	punct	.,revealed
R7064	T23483	T23484	expl	There,was
R7065	T23485	T23486	det	a,response
R7066	T23486	T23484	attr	response,was
R7067	T23487	T23488	advmod	slightly,lower
R7068	T23488	T23486	amod	lower,response
R7069	T23489	T23486	prep	in,response
R7070	T23490	T23491	det	the,retina
R7071	T23491	T23489	pobj	retina,in
R7072	T23492	T23493	compound	Rb,E2f1
R7073	T23493	T23495	compound	E2f1,DKO
R7074	T23494	T23493	punct	/,E2f1
R7075	T23495	T23491	compound	DKO,retina
R7076	T23496	T23484	advcl	relative,was
R7077	T23497	T23496	prep	to,relative
R7078	T23498	T23499	det	the,retina
R7079	T23499	T23497	pobj	retina,to
R7080	T23500	T23501	compound	E2f1,KO
R7081	T23501	T23499	compound	KO,retina
R7082	T23502	T23499	compound	control,retina
R7083	T23503	T23484	punct	.,was
R7084	T23505	T23506	det	This,difference
R7085	T23506	T23507	nsubj	difference,reflect
R7086	T23508	T23507	aux	might,reflect
R7087	T23509	T23510	det	a,role
R7088	T23510	T23507	dobj	role,reflect
R7089	T23511	T23510	prep	for,role
R7090	T23512	T23511	pobj	Rb,for
R7091	T23513	T23510	prep	in,role
R7092	T23514	T23515	det	the,development
R7093	T23515	T23513	pobj	development,in
R7094	T23516	T23515	prep	of,development
R7095	T23517	T23516	pobj	cones,of
R7096	T23518	T23517	punct	", ",cones
R7097	T23519	T23520	amod	bipolar,cells
R7098	T23520	T23517	conj	cells,cones
R7099	T23521	T23520	punct	", ",cells
R7100	T23522	T23520	cc	or,cells
R7101	T23523	T23524	amod	other,cells
R7102	T23524	T23520	conj	cells,cells
R7103	T23525	T23526	dep	that,contribute
R7104	T23526	T23524	relcl	contribute,cells
R7105	T23527	T23526	aux	may,contribute
R7106	T23528	T23526	prep	to,contribute
R7107	T23529	T23530	det	the,ERG
R7108	T23530	T23528	pobj	ERG,to
R7109	T23531	T23530	amod	photopic,ERG
R7110	T23532	T23524	punct	", ",cells
R7111	T23533	T23524	prep	including,cells
R7112	T23534	T23535	advmod	potentially,SACs
R7113	T23535	T23533	pobj	SACs,including
R7114	T23536	T23535	punct	", ",SACs
R7115	T23537	T23538	dep	which,have
R7116	T23538	T23535	relcl	have,SACs
R7117	T23539	T23538	aux	do,have
R7118	T23540	T23541	det	a,defect
R7119	T23541	T23538	dobj	defect,have
R7120	T23542	T23541	amod	serious,defect
R7121	T23543	T23541	prep	in,defect
R7122	T23544	T23545	det	the,retina
R7123	T23545	T23543	pobj	retina,in
R7124	T23546	T23547	compound	Rb,E2f1
R7125	T23547	T23549	compound	E2f1,DKO
R7126	T23548	T23547	punct	/,E2f1
R7127	T23549	T23545	compound	DKO,retina
R7128	T23550	T23507	punct	.,reflect
R7129	T24609	T24610	nsubj	Rb,Controls
R7130	T24611	T24612	compound	SAC,Differentiation
R7131	T24612	T24610	dobj	Differentiation,Controls
R7132	T24613	T24610	prep	through,Controls
R7133	T24614	T24613	pobj	E2f3a,through
R7134	T24616	T24617	amod	Comprehensive,analysis
R7135	T24617	T24619	nsubj	analysis,revealed
R7136	T24618	T24617	compound	marker,analysis
R7137	T24620	T24621	mark	that,suppress
R7138	T24621	T24619	ccomp	suppress,revealed
R7139	T24622	T24621	punct	", ",suppress
R7140	T24623	T24621	prep	in,suppress
R7141	T24624	T24625	amod	striking,contrast
R7142	T24625	T24623	pobj	contrast,in
R7143	T24626	T24625	prep	to,contrast
R7144	T24627	T24628	amod	other,neurons
R7145	T24628	T24626	pobj	neurons,to
R7146	T24629	T24628	amod	retinal,neurons
R7147	T24630	T24621	punct	", ",suppress
R7148	T24631	T24632	compound	E2f1,deletion
R7149	T24632	T24621	nsubj	deletion,suppress
R7150	T24633	T24621	aux	did,suppress
R7151	T24634	T24621	neg	not,suppress
R7152	T24635	T24621	dobj	defects,suppress
R7153	T24636	T24621	prep	in,suppress
R7154	T24637	T24638	nmod	Rb,KO
R7155	T24638	T24639	nmod	KO,SACs
R7156	T24639	T24636	pobj	SACs,in
R7157	T24640	T24639	amod	cholinergic,SACs
R7158	T24641	T24619	punct	.,revealed
R7159	T24643	T24644	advmod	Instead,observed
R7160	T24645	T24644	punct	", ",observed
R7161	T24646	T24644	nsubj	we,observed
R7162	T24647	T24648	npadvmod	E2f1,independent
R7163	T24648	T24650	amod	independent,defects
R7164	T24649	T24648	punct	-,independent
R7165	T24650	T24644	dobj	defects,observed
R7166	T24651	T24650	prep	in,defects
R7167	T24652	T24653	det	the,synthesis
R7168	T24653	T24651	pobj	synthesis,in
R7169	T24654	T24653	cc	and,synthesis
R7170	T24655	T24653	conj	transport,synthesis
R7171	T24656	T24653	prep	of,synthesis
R7172	T24657	T24658	det	a,cohort
R7173	T24658	T24656	pobj	cohort,of
R7174	T24659	T24658	amod	large,cohort
R7175	T24660	T24658	prep	of,cohort
R7176	T24661	T24662	compound	SAC,proteins
R7177	T24662	T24660	pobj	proteins,of
R7178	T24663	T24644	punct	.,observed
R7179	T24665	T24666	det	These,data
R7180	T24666	T24667	nsubj	data,expand
R7181	T24668	T24667	dobj	insight,expand
R7182	T24669	T24668	prep	into,insight
R7183	T24670	T24671	det	the,development
R7184	T24671	T24669	pobj	development,into
R7185	T24672	T24671	prep	of,development
R7186	T24673	T24674	det	these,interneurons
R7187	T24674	T24672	pobj	interneurons,of
R7188	T24675	T24674	amod	important,interneurons
R7189	T24676	T24667	punct	", ",expand
R7190	T24677	T24667	cc	but,expand
R7191	T24678	T24679	advmod	more,critically
R7192	T24679	T24680	advmod	critically,provide
R7193	T24680	T24667	conj	provide,expand
R7194	T24681	T24680	punct	", ",provide
R7195	T24682	T24680	prep	to,provide
R7196	T24683	T24684	poss	our,knowledge
R7197	T24684	T24682	pobj	knowledge,to
R7198	T24685	T24686	det	the,evidence
R7199	T24686	T24680	dobj	evidence,provide
R7200	T24687	T24686	amod	first,evidence
R7201	T24688	T24686	amod	unambiguous,evidence
R7202	T24689	T24690	mark	that,regulates
R7203	T24690	T24686	acl	regulates,evidence
R7204	T24691	T24690	nsubj	Rb,regulates
R7205	T24692	T24690	dobj	neurogenesis,regulates
R7206	T24693	T24690	prep	beyond,regulates
R7207	T24694	T24695	amod	terminal,mitosis
R7208	T24695	T24693	pobj	mitosis,beyond
R7209	T24696	T24667	punct	.,expand
R7210	T24698	T24699	nsubj	Rb,binds
R7211	T24700	T24701	amod	more,100
R7212	T24701	T24703	nummod	100,factors
R7213	T24702	T24701	quantmod	than,100
R7214	T24703	T24699	dobj	factors,binds
R7215	T24704	T24705	punct	[,43
R7216	T24705	T24699	parataxis	43,binds
R7217	T24706	T24705	punct	],43
R7218	T24707	T24699	punct	", ",binds
R7219	T24708	T24699	cc	and,binds
R7220	T24709	T24710	prep	in,binds
R7221	T24710	T24699	conj	binds,binds
R7222	T24711	T24712	amod	several,cells
R7223	T24712	T24709	pobj	cells,in
R7224	T24713	T24712	amod	non-neuronal,cells
R7225	T24714	T24712	punct	", ",cells
R7226	T24715	T24716	amod	such,as
R7227	T24716	T24712	prep	as,cells
R7228	T24717	T24718	amod	skeletal,muscle
R7229	T24718	T24716	pobj	muscle,as
R7230	T24719	T24718	punct	", ",muscle
R7231	T24720	T24718	conj	adipocytes,muscle
R7232	T24721	T24720	punct	", ",adipocytes
R7233	T24722	T24720	cc	and,adipocytes
R7234	T24723	T24720	conj	bone,adipocytes
R7235	T24724	T24710	punct	", ",binds
R7236	T24725	T24710	nsubj	it,binds
R7237	T24726	T24710	cc	and,binds
R7238	T24727	T24710	conj	potentiates,binds
R7239	T24728	T24729	npadvmod	tissue,specific
R7240	T24729	T24731	amod	specific,factors
R7241	T24730	T24729	punct	-,specific
R7242	T24731	T24727	dobj	factors,potentiates
R7243	T24732	T24731	compound	transcription,factors
R7244	T24733	T24734	dep	that,promote
R7245	T24734	T24731	relcl	promote,factors
R7246	T24735	T24734	dobj	differentiation,promote
R7247	T24736	T24737	punct	[,31
R7248	T24737	T24727	parataxis	31,potentiates
R7249	T24738	T24739	punct	–,33
R7250	T24739	T24737	prep	33,31
R7251	T24740	T24737	punct	],31
R7252	T24741	T24710	punct	.,binds
R7253	T24743	T24744	det	The,idea
R7254	T24744	T24745	nsubjpass	idea,contested
R7255	T24746	T24747	mark	that,promotes
R7256	T24747	T24744	acl	promotes,idea
R7257	T24748	T24747	nsubj	Rb,promotes
R7258	T24749	T24750	compound	muscle,differentiation
R7259	T24750	T24747	dobj	differentiation,promotes
R7260	T24751	T24747	prep	by,promotes
R7261	T24752	T24751	pcomp	potentiating,by
R7262	T24753	T24754	compound	Myod1,activity
R7263	T24754	T24752	dobj	activity,potentiating
R7264	T24755	T24745	auxpass	was,contested
R7265	T24756	T24757	punct	[,61
R7266	T24757	T24745	parataxis	61,contested
R7267	T24758	T24757	punct	],61
R7268	T24759	T24745	punct	", ",contested
R7269	T24760	T24745	cc	and,contested
R7270	T24761	T24762	amod	other,mechanisms
R7271	T24762	T24763	nsubj	mechanisms,proposed
R7307	T24822	T24821	pobj	E2f3,h
R7308	T24824	T24820	acomp	independent,was
R7309	T24825	T24824	prep	of,independent
R7310	T24826	T24827	poss	its,role
R7311	T24827	T24825	pobj	role,of
R7312	T24828	T24827	prep	in,role
R7313	T24829	T24828	pcomp	controlling,in
R7314	T24830	T24829	dobj	division,controlling
R7315	T24831	T24830	cc	or,division
R7316	T24832	T24830	conj	death,division
R7317	T24833	T24823	punct	: ,rescued
R7318	T24834	T24835	compound	E2f3,deletion
R7319	T24835	T24823	nsubj	deletion,rescued
R7320	T24836	T24837	compound	Rb,KO
R7321	T24837	T24838	compound	KO,defects
R7322	T24838	T24823	dobj	defects,rescued
R7323	T24839	T24838	compound	SAC,defects
R7324	T24840	T24823	cc	but,rescued
R7325	T24841	T24842	aux	did,suppress
R7326	T24842	T24823	conj	suppress,rescued
R7327	T24843	T24842	neg	not,suppress
R7328	T24844	T24845	amod	aberrant,proliferation
R7329	T24845	T24842	dobj	proliferation,suppress
R7330	T24846	T24845	cc	or,proliferation
R7331	T24847	T24845	conj	death,proliferation
R7332	T24848	T24842	punct	", ",suppress
R7333	T24849	T24850	mark	whereas,reversed
R7334	T24850	T24842	advcl	reversed,suppress
R7335	T24851	T24852	compound	E2f1,deletion
R7336	T24852	T24850	nsubj	deletion,reversed
R7337	T24853	T24854	amod	abnormal,proliferation
R7338	T24854	T24850	dobj	proliferation,reversed
R7339	T24855	T24854	cc	and,proliferation
R7340	T24856	T24854	conj	death,proliferation
R7341	T24857	T24850	cc	but,reversed
R7342	T24858	T24859	aux	did,rescue
R7343	T24859	T24850	conj	rescue,reversed
R7344	T24860	T24859	neg	not,rescue
R7345	T24861	T24862	compound	SAC,differentiation
R7346	T24862	T24859	dobj	differentiation,rescue
R7347	T24863	T24823	punct	.,rescued
R7348	T24865	T24866	amod	Double,labelling
R7349	T24866	T24867	nsubj	labelling,confirmed
R7350	T24868	T24869	mark	that,reversed
R7351	T24869	T24867	ccomp	reversed,confirmed
R7352	T24870	T24871	nmod	E2f1,deletion
R7353	T24871	T24869	nsubj	deletion,reversed
R7354	T24872	T24870	cc	but,E2f1
R7355	T24873	T24872	neg	not,but
R7356	T24874	T24870	conj	E2f3,E2f1
R7357	T24875	T24876	compound	Rb,KO
R7358	T24876	T24877	compound	KO,SAC
R7359	T24877	T24878	compound	SAC,division
R7360	T24878	T24869	dobj	division,reversed
R7361	T24879	T24867	punct	.,confirmed
R7362	T24881	T24882	advmod	Moreover,reversed
R7363	T24883	T24882	punct	", ",reversed
R7364	T24884	T24882	csubj	deleting,reversed
R7365	T24885	T24884	dobj	E2f1,deleting
R7366	T24886	T24885	punct	", ",E2f1
R7367	T24887	T24885	cc	but,E2f1
R7368	T24888	T24887	neg	not,but
R7369	T24889	T24885	conj	E2f3,E2f1
R7370	T24890	T24882	punct	", ",reversed
R7371	T24891	T24892	amod	deregulated,expression
R7372	T24892	T24882	dobj	expression,reversed
R7373	T24893	T24892	prep	of,expression
R7374	T24894	T24895	compound	cell,cycle
R7375	T24895	T24893	pobj	cycle,of
R7376	T24896	T24895	cc	and,cycle
R7377	T24897	T24898	amod	apoptotic,genes
R7378	T24898	T24895	conj	genes,cycle
R7379	T24899	T24882	prep	in,reversed
R7380	T24900	T24901	det	the,retina
R7381	T24901	T24899	pobj	retina,in
R7382	T24902	T24903	compound	Rb,KO
R7383	T24903	T24901	compound	KO,retina
R7384	T24904	T24882	punct	.,reversed
R7385	T24906	T24907	nsubjpass	E2f3,expressed
R7386	T24908	T24907	auxpass	is,expressed
R7387	T24909	T24907	prep	in,expressed
R7388	T24910	T24911	det	a,subset
R7389	T24911	T24909	pobj	subset,in
R7400	T24922	T24920	dobj	defects,drives
R7402	T24924	T24926	npadvmod	cycle,independent
R7403	T24925	T24924	punct	-,cycle
R7404	T24926	T24922	amod	independent,defects
R7405	T24927	T24926	punct	–,independent
R7406	T24928	T24920	prep	in,drives
R7407	T24929	T24930	compound	Rb,KO
R7408	T24930	T24931	compound	KO,neurons
R7409	T24931	T24928	pobj	neurons,in
R7410	T24932	T24931	compound	forebrain,neurons
R7411	T24933	T24934	punct	[,53
R7412	T24934	T24920	parataxis	53,drives
R7413	T24935	T24934	punct	],53
R7414	T24936	T24907	punct	.,expressed
R7415	T24938	T24939	advmod	Thus,is
R7416	T24940	T24939	punct	", ",is
R7417	T24941	T24942	compound	E2f3,inhibition
R7418	T24942	T24939	nsubj	inhibition,is
R7419	T24943	T24944	det	the,first
R7420	T24944	T24939	attr	first,is
R7421	T24945	T24939	punct	", ",is
R7422	T24946	T24939	cc	and,is
R7423	T24947	T24948	aux	may,be
R7424	T24948	T24939	conj	be,is
R7425	T24949	T24950	det	the,only
R7426	T24950	T24948	attr	only,be
R7427	T24951	T24948	punct	", ",be
R7428	T24952	T24948	conj	mechanism,be
R7429	T24953	T24954	prep	by,participates
R7430	T24954	T24952	ccomp	participates,mechanism
R7431	T24955	T24953	pobj	which,by
R7432	T24956	T24954	nsubj	Rb,participates
R7433	T24957	T24954	advmod	directly,participates
R7434	T24958	T24954	prep	in,participates
R7435	T24959	T24960	amod	neuronal,differentiation
R7436	T24960	T24958	pobj	differentiation,in
R7437	T24961	T24939	punct	.,is
R7438	T24963	T24964	aux	To,dissect
R7439	T24964	T24966	advcl	dissect,determined
R7440	T24965	T24964	advmod	further,dissect
R7441	T24967	T24968	det	the,mechanism
R7442	T24968	T24964	dobj	mechanism,dissect
R7443	T24969	T24968	prep	of,mechanism
R7444	T24970	T24969	pobj	action,of
R7445	T24971	T24968	prep	of,mechanism
R7446	T24972	T24971	pobj	Rb,of
R7447	T24973	T24968	prep	in,mechanism
R7448	T24974	T24973	pobj	SACs,in
R7449	T24975	T24966	nsubj	we,determined
R7450	T24976	T24977	det	the,isoform
R7451	T24977	T24966	dobj	isoform,determined
R7452	T24978	T24977	compound	E2f3,isoform
R7453	T24979	T24980	nsubj	it,targets
R7454	T24980	T24977	advcl	targets,isoform
R7455	T24981	T24982	aux	to,promote
R7456	T24982	T24980	advcl	promote,targets
R7457	T24983	T24982	dobj	differentiation,promote
R7458	T24984	T24966	punct	.,determined
R7459	T24986	T24987	nsubj	E2f3b,was
R7460	T24988	T24989	det	the,candidate
R7461	T24989	T24987	attr	candidate,was
R7462	T24990	T24989	amod	primary,candidate
R7463	T24991	T24987	punct	", ",was
R7464	T24992	T24993	mark	since,collaborate
R7465	T24993	T24987	advcl	collaborate,was
R7466	T24994	T24993	nsubj	Rb,collaborate
R7467	T24995	T24994	cc	and,Rb
R7468	T24996	T24994	conj	E2f3b,Rb
R7469	T24997	T24998	aux	to,repress
R7470	T24998	T24993	advcl	repress,collaborate
R7471	T24999	T24998	dobj	targets,repress
R7472	T25000	T24998	prep	in,repress
R7473	T25001	T25002	amod	quiescent,cells
R7474	T25002	T25000	pobj	cells,in
R7475	T25003	T25004	advmod	in,vitro
R7476	T25004	T24998	advmod	vitro,repress
R7477	T25005	T25006	punct	[,19
R7478	T25006	T24998	parataxis	19,repress
R7479	T25007	T25006	punct	],19
R7480	T25008	T24987	punct	.,was
R7481	T25010	T25011	advmod	However,made
R7482	T25012	T25011	punct	", ",made
R7483	T25013	T25011	prep	in,made
R7484	T25014	T25015	det	the,work
R7485	T25015	T25013	pobj	work,in
R7486	T25016	T25015	amod	first,work
R7487	T25017	T25018	prep	to,examine
R7488	T25018	T25015	advcl	examine,work
R7489	T25019	T25020	poss	our,knowledge
R7490	T25020	T25017	pobj	knowledge,to
R7491	T25021	T25018	aux	to,examine
R7492	T25022	T25023	det	the,function
R7493	T25023	T25018	dobj	function,examine
R7494	T25024	T25023	prep	of,function
R7495	T25025	T25026	det	any,isoform
R7496	T25026	T25024	pobj	isoform,of
R7497	T25027	T25028	compound	E2f,protein
R7498	T25028	T25026	compound	protein,isoform
R7499	T25029	T25030	advmod	in,vivo
R7500	T25030	T25018	advmod	vivo,examine
R7501	T25031	T25011	punct	", ",made
R7502	T25032	T25011	nsubj	we,made
R7503	T25033	T25034	det	the,observation
R7504	T25034	T25011	dobj	observation,made
R7505	T25035	T25034	amod	surprising,observation
R7506	T25036	T25037	mark	that,regulates
R7507	T25037	T25034	acl	regulates,observation
R7508	T25038	T25037	nsubj	Rb,regulates
R7509	T25039	T25040	compound	SAC,differentiation
R7510	T25040	T25037	dobj	differentiation,regulates
R7511	T25041	T25037	prep	through,regulates
R7512	T25042	T25041	pobj	E2f3a,through
R7513	T25043	T25044	punct	(,Figure
R7514	T25044	T25037	parataxis	Figure,regulates
R7515	T25045	T25044	nummod	8,Figure
R7516	T25046	T25044	punct	),Figure
R7517	T25047	T25011	punct	.,made
R7518	T25049	T25050	advmod	Formally,exclude
R7519	T25051	T25050	punct	", ",exclude
R7520	T25052	T25050	nsubj	we,exclude
R7521	T25053	T25050	aux	can,exclude
R7522	T25054	T25050	neg	not,exclude
R7523	T25055	T25056	det	the,possibility
R7524	T25056	T25050	dobj	possibility,exclude
R7525	T25057	T25058	mark	that,rescue
R7526	T25058	T25056	acl	rescue,possibility
R7527	T25059	T25058	csubj	deleting,rescue
R7528	T25060	T25059	dobj	E2f3b,deleting
R7529	T25061	T25058	aux	might,rescue
R7530	T25062	T25058	advmod	also,rescue
R7531	T25063	T25064	compound	SAC,differentiation
R7532	T25064	T25058	dobj	differentiation,rescue
R7533	T25065	T25050	punct	", ",exclude
R7534	T25066	T25050	cc	but,exclude
R7535	T25067	T25068	amod	definitive,proof
R7536	T25068	T25069	nsubj	proof,require
R7537	T25069	T25050	conj	require,exclude
R7538	T25070	T25069	aux	will,require
R7539	T25071	T25069	dobj	analysis,require
R7540	T25072	T25071	prep	of,analysis
R7541	T25073	T25074	npadvmod	E2f3b,null
R7542	T25074	T25075	amod	null,mice
R7543	T25075	T25072	pobj	mice,of
R7544	T25076	T25069	punct	.,require
R7545	T25078	T25079	advmod	Nevertheless,prove
R7546	T25080	T25079	punct	", ",prove
R7547	T25081	T25082	poss	our,data
R7548	T25082	T25079	nsubj	data,prove
R7549	T25083	T25084	mark	that,regulates
R7550	T25084	T25079	ccomp	regulates,prove
R7551	T25085	T25084	nsubj	Rb,regulates
R7552	T25086	T25084	advmod	definitely,regulates
R7553	T25087	T25088	compound	SAC,differentiation
R7554	T25088	T25084	dobj	differentiation,regulates
R7555	T25089	T25084	prep	through,regulates
R7556	T25090	T25091	det	the,isoform
R7557	T25091	T25089	pobj	isoform,through
R7558	T25092	T25091	amod	activating,isoform
R7559	T25093	T25091	compound	E2f3,isoform
R7560	T25094	T25079	punct	.,prove
R7561	T25716	T25717	amod	Distinct,Localization
R7562	T25718	T25717	nmod	E2f3a,Localization
R7563	T25719	T25718	cc	and,E2f3a
R7564	T25720	T25718	conj	E2f3b,E2f3a
R7565	T25722	T25723	det	The,location
R7566	T25723	T25725	nsubjpass	location,addressed
R7567	T25724	T25723	amod	subcellular,location
R7568	T25726	T25723	prep	of,location
R7569	T25727	T25728	compound	E2f,isoforms
R7570	T25728	T25726	pobj	isoforms,of
R7571	T25729	T25725	aux	has,addressed
R7572	T25730	T25725	neg	not,addressed
R7573	T25731	T25725	prep	to,addressed
R7574	T25732	T25733	poss	our,knowledge
R7575	T25733	T25731	pobj	knowledge,to
R7576	T25734	T25725	auxpass	been,addressed
R7577	T25735	T25725	advmod	before,addressed
R7578	T25736	T25725	punct	.,addressed
R7579	T25738	T25739	nsubj	E2f3a,share
R7580	T25740	T25738	cc	and,E2f3a
R7581	T25741	T25738	conj	E2f3b,E2f3a
R7582	T25742	T25743	nummod	110,acids
R7583	T25743	T25739	dobj	acids,share
R7584	T25744	T25745	npadvmod	C,terminal
R7585	T25745	T25743	amod	terminal,acids
R7586	T25746	T25745	punct	-,terminal
R7587	T25747	T25743	compound	amino,acids
R7588	T25748	T25749	dep	that,encode
R7589	T25749	T25743	relcl	encode,acids
R7590	T25750	T25751	det	the,domains
R7591	T25751	T25749	dobj	domains,encode
R7592	T25752	T25751	nmod	NLS,domains
R7593	T25753	T25752	punct	", ",NLS
R7594	T25754	T25752	conj	DNA,NLS
R7595	T25755	T25754	punct	-,DNA
R7596	T25756	T25754	amod	binding,DNA
R7597	T25757	T25754	punct	", ",DNA
R7598	T25758	T25759	amod	marked,box
R7599	T25759	T25754	conj	box,DNA
R7600	T25760	T25759	punct	", ",box
R7601	T25761	T25759	conj	transactivation,box
R7602	T25762	T25761	punct	", ",transactivation
R7603	T25763	T25761	cc	and,transactivation
R7604	T25764	T25761	conj	Rb,transactivation
R7605	T25765	T25764	punct	-,Rb
R7606	T25766	T25764	amod	binding,Rb
R7607	T25767	T25768	punct	[,16
R7608	T25768	T25739	parataxis	16,share
R7609	T25769	T25768	punct	],16
R7610	T25770	T25739	punct	", ",share
R7611	T25771	T25739	cc	yet,share
R7612	T25772	T25773	nsubj	they,exhibit
R7613	T25773	T25739	conj	exhibit,share
R7614	T25774	T25775	amod	different,distribution
R7615	T25775	T25773	dobj	distribution,exhibit
R7616	T25776	T25775	amod	subcellular,distribution
R7617	T25777	T25773	prep	in,exhibit
R7618	T25778	T25779	amod	developing,cells
R7619	T25779	T25777	pobj	cells,in
R7620	T25780	T25779	amod	retinal,cells
R7621	T25781	T25773	punct	.,exhibit
R7622	T25783	T25784	nsubj	E2f3a,is
R7623	T25785	T25786	preconj	both,nuclear
R7624	T25786	T25784	acomp	nuclear,is
R7625	T25787	T25786	cc	and,nuclear
R7626	T25788	T25786	conj	cytoplasmic,nuclear
R7627	T25789	T25784	punct	", ",is
R7628	T25790	T25784	cc	but,is
R7629	T25791	T25792	nsubj	E2f3b,is
R7630	T25792	T25784	conj	is,is
R7631	T25793	T25792	advmod	always,is
R7632	T25794	T25792	acomp	nuclear,is
R7633	T25795	T25792	punct	.,is
R7634	T25797	T25798	det	The,termini
R7635	T25798	T25808	nsubj	termini,mediate
R7636	T25799	T25798	amod	unique,termini
R7637	T25800	T25801	nummod	121,residue
R7638	T25801	T25798	compound	residue,termini
R7639	T25802	T25800	punct	-,121
R7640	T25803	T25800	cc	and,121
R7641	T25804	T25800	conj	six,121
R7642	T25805	T25801	punct	-,residue
R7643	T25806	T25798	compound	N,termini
R7644	T25807	T25798	punct	-,termini
R7645	T25809	T25798	prep	of,termini
R7646	T25810	T25809	pobj	E2f3a,of
R7647	T25811	T25810	cc	and,E2f3a
R7648	T25812	T25810	conj	E2f3b,E2f3a
R7649	T25813	T25808	punct	", ",mediate
R7650	T25814	T25808	advmod	respectively,mediate
R7651	T25815	T25808	punct	", ",mediate
R7652	T25816	T25808	advmod	likely,mediate
R7653	T25817	T25818	det	this,difference
R7654	T25818	T25808	dobj	difference,mediate
R7655	T25819	T25808	punct	.,mediate
R7656	T25821	T25822	det	This,region
R7657	T25822	T25823	nsubj	region,binds
R7658	T25824	T25822	prep	in,region
R7659	T25825	T25824	pobj	E2f1,in
R7660	T25826	T25825	punct	", ",E2f1
R7661	T25827	T25825	conj	E2f2,E2f1
R7662	T25828	T25827	punct	", ",E2f2
R7663	T25829	T25827	cc	and,E2f2
R7664	T25830	T25827	conj	E2f3a,E2f2
R7665	T25831	T25823	dobj	Ccna2,binds
R7666	T25832	T25823	punct	", ",binds
R7667	T25833	T25823	advcl	establishing,binds
R7668	T25834	T25835	det	a,loop
R7669	T25835	T25833	dobj	loop,establishing
R7670	T25836	T25835	amod	negative,loop
R7671	T25837	T25835	amod	regulatory,loop
R7672	T25838	T25839	dep	that,deactivates
R7673	T25839	T25835	relcl	deactivates,loop
R7674	T25840	T25839	dobj	E2fs,deactivates
R7675	T25841	T25839	prep	in,deactivates
R7676	T25842	T25843	amod	mid,late
R7677	T25843	T25845	amod	late,phase
R7678	T25844	T25843	punct	-,late
R7679	T25845	T25841	pobj	phase,in
R7680	T25846	T25845	compound	S,phase
R7681	T25847	T25845	punct	-,phase
R7682	T25848	T25849	punct	[,65
R7683	T25849	T25833	parataxis	65,establishing
R7684	T25850	T25849	nummod	64,65
R7685	T25851	T25849	punct	",",65
R7686	T25852	T25849	punct	],65
R7687	T25853	T25823	punct	.,binds
R7688	T25855	T25856	advmod	However,binds
R7689	T25857	T25856	punct	", ",binds
R7690	T25858	T25859	advmod	even,E2f3b
R7691	T25859	T25856	nsubj	E2f3b,binds
R7692	T25860	T25859	punct	", ",E2f3b
R7693	T25861	T25862	dep	which,lacks
R7694	T25862	T25859	relcl	lacks,E2f3b
R7695	T25863	T25864	det	this,domain
R7696	T25864	T25862	dobj	domain,lacks
R7697	T25865	T25856	punct	", ",binds
R7698	T25866	T25856	cc	and,binds
R7699	T25867	T25868	auxpass	is,regulated
R7700	T25868	T25856	conj	regulated,binds
R7701	T25869	T25868	agent	by,regulated
R7702	T25870	T25868	dobj	Ccna2,regulated
R7703	T25871	T25872	punct	[,18
R7704	T25872	T25870	parataxis	18,Ccna2
R7705	T25873	T25872	punct	],18
R7706	T25874	T25856	punct	", ",binds
R7707	T25875	T25876	mark	so,explain
R7708	T25876	T25856	advcl	explain,binds
R7709	T25877	T25878	det	the,difference
R7710	T25878	T25876	nsubj	difference,explain
R7711	T25879	T25878	compound	domain,difference
R7712	T25880	T25876	aux	may,explain
R7713	T25881	T25876	neg	not,explain
R7714	T25882	T25883	det	the,distributions
R7715	T25883	T25876	dobj	distributions,explain
R7716	T25884	T25883	amod	unique,distributions
R7717	T25885	T25886	nsubj	we,observed
R7718	T25886	T25883	advcl	observed,distributions
R7719	T25887	T25856	punct	.,binds
R7720	T25889	T25890	nmod	Rb,family
R7721	T25890	T25891	nmod	family,proteins
R7722	T25891	T25894	nsubj	proteins,determine
R7723	T25892	T25890	cc	and,family
R7724	T25893	T25890	conj	Tfdp,family
R7725	T25895	T25894	aux	can,determine
R7726	T25896	T25894	advmod	also,determine
R7727	T25897	T25898	compound	E2f,localization
R7728	T25898	T25894	dobj	localization,determine
R7729	T25899	T25900	punct	[,20
R7730	T25900	T25894	parataxis	20,determine
R7731	T25901	T25902	punct	–,22
R7732	T25902	T25900	prep	22,20
R7733	T25903	T25900	punct	],20
R7734	T25904	T25894	punct	", ",determine
R7735	T25905	T25894	cc	and,determine
R7736	T25906	T25907	nsubj	we,found
R7737	T25907	T25894	conj	found,determine
R7738	T25908	T25909	mark	that,are
R7739	T25909	T25907	ccomp	are,found
R7740	T25910	T25911	det	a,portion
R7741	T25911	T25909	nsubj	portion,are
R7742	T25912	T25911	prep	of,portion
R7743	T25913	T25914	preconj	both,Rb
R7744	T25914	T25915	nmod	Rb,proteins
R7745	T25915	T25912	pobj	proteins,of
R7746	T25916	T25914	cc	and,Rb
R7747	T25917	T25914	conj	Tfdp1,Rb
R7748	T25918	T25909	acomp	cytoplasmic,are
R7749	T25919	T25909	prep	in,are
R7750	T25920	T25921	amod	retinal,cells
R7751	T25921	T25919	pobj	cells,in
R7752	T25922	T25907	punct	.,found
R7753	T25924	T25925	advmod	Indeed,revealed
R7754	T25926	T25925	punct	", ",revealed
R7755	T25927	T25925	nsubj	immunostaining,revealed
R7756	T25928	T25929	mark	that,colocalize
R7757	T25929	T25925	ccomp	colocalize,revealed
R7758	T25930	T25929	nsubj	Rb,colocalize
R7759	T25931	T25930	cc	and,Rb
R7760	T25932	T25930	conj	E2f3,Rb
R7761	T25933	T25929	prep	to,colocalize
R7762	T25934	T25935	compound	SAC,processes
R7763	T25935	T25933	pobj	processes,to
R7764	T25936	T25925	punct	.,revealed
R7765	T25938	T25939	det	The,localization
R7766	T25939	T25941	nsubj	localization,contrasts
R7767	T25940	T25939	amod	nuclear,localization
R7768	T25942	T25939	prep	of,localization
R7769	T25943	T25942	pobj	E2f3b,of
R7770	T25944	T25941	prep	with,contrasts
R7771	T25945	T25944	pobj	that,with
R7772	T25946	T25945	prep	of,that
R7773	T25947	T25948	amod	other,E2fs
R7774	T25948	T25946	pobj	E2fs,of
R7775	T25949	T25948	amod	repressive,E2fs
R7776	T25950	T25948	prep	in,E2fs
R7777	T25951	T25952	amod	differentiating,muscle
R7778	T25952	T25950	pobj	muscle,in
R7779	T25953	T25952	punct	", ",muscle
R7780	T25954	T25955	advmod	where,switches
R7781	T25955	T25952	relcl	switches,muscle
R7782	T25956	T25955	nsubj	E2f5,switches
R7783	T25957	T25955	prep	from,switches
R7784	T25958	T25959	det	the,nucleus
R7785	T25959	T25957	pobj	nucleus,from
R7786	T25960	T25957	prep	to,from
R7787	T25961	T25960	pobj	cytoplasm,to
R7788	T25962	T25941	punct	", ",contrasts
R7789	T25963	T25964	mark	while,remains
R7790	T25964	T25941	advcl	remains,contrasts
R7791	T25965	T25964	nsubj	E2f4,remains
R7792	T25966	T25964	prep	in,remains
R7793	T25967	T25968	det	both,compartments
R7794	T25968	T25966	pobj	compartments,in
R7795	T25969	T25970	punct	[,23
R7796	T25970	T25964	parataxis	23,remains
R7797	T25971	T25970	punct	],23
R7798	T25972	T25941	punct	.,contrasts
R7799	T25974	T25975	det	The,compartmentalization
R7800	T25975	T25977	nsubj	compartmentalization,suggests
R7801	T25976	T25975	amod	distinct,compartmentalization
R7802	T25978	T25975	prep	of,compartmentalization
R7803	T25979	T25978	pobj	E2f3a,of
R7804	T25980	T25979	cc	and,E2f3a
R7805	T25981	T25979	conj	E2f3b,E2f3a
R7806	T25982	T25975	prep	in,compartmentalization
R7807	T25983	T25984	det	the,retina
R7808	T25984	T25982	pobj	retina,in
R7809	T25985	T25986	advmod	temporally,distinct
R7810	T25986	T25989	amod	distinct,activities
R7811	T25987	T25985	cc	and,temporally
R7812	T25988	T25985	conj	functionally,temporally
R7813	T25989	T25977	dobj	activities,suggests
R7814	T25990	T25977	punct	.,suggests
R7815	T25992	T25993	compound	Rb,distribution
R7816	T25993	T25994	nsubj	distribution,matches
R7817	T25995	T25994	dobj	that,matches
R7818	T25996	T25995	prep	of,that
R7819	T25997	T25996	pobj	E2f3a,of
R7820	T25998	T25994	punct	", ",matches
R7821	T25999	T25994	advcl	consistent,matches
R7822	T26000	T25999	prep	with,consistent
R7823	T26001	T26002	poss	its,role
R7824	T26002	T26000	pobj	role,with
R7825	T26003	T26002	amod	critical,role
R7826	T26004	T26002	prep	in,role
R7827	T26005	T26004	pcomp	supporting,in
R7828	T26006	T26007	compound	SAC,differentiation
R7829	T26007	T26005	dobj	differentiation,supporting
R7830	T26008	T26005	prep	through,supporting
R7831	T26009	T26008	pobj	E2f3a,through
R7832	T26010	T25994	punct	.,matches
R7837	T26609	T26610	amod	Ectopic,Division
R7838	T26611	T26610	cc	and,Division
R7839	T26612	T26610	conj	Differentiation,Division
R7840	T26614	T26615	nsubj	Rb,is
R7841	T26616	T26615	acomp	critical,is
R7842	T26617	T26618	aux	to,ensure
R7843	T26618	T26616	xcomp	ensure,critical
R7844	T26619	T26620	mark	that,leave
R7845	T26620	T26618	ccomp	leave,ensure
R7846	T26621	T26622	amod	many,types
R7847	T26622	T26620	nsubj	types,leave
R7848	T26623	T26622	prep	of,types
R7849	T26624	T26625	advmod	terminally,differentiating
R7850	T26625	T26626	amod	differentiating,cells
R7851	T26626	T26623	pobj	cells,of
R7852	T26627	T26628	det	the,cycle
R7853	T26628	T26620	dative	cycle,leave
R7854	T26629	T26628	compound	cell,cycle
R7855	T26630	T26620	punct	(,leave
R7856	T26631	T26632	advmod	e.g.,neurons
R7857	T26632	T26620	dobj	neurons,leave
R7858	T26633	T26632	punct	", ",neurons
R7859	T26634	T26632	punct	", ",neurons
R7860	T26635	T26636	nmod	gut,epithelia
R7861	T26636	T26632	conj	epithelia,neurons
R7862	T26637	T26635	cc	and,gut
R7863	T26638	T26635	conj	skin,gut
R7864	T26639	T26636	punct	", ",epithelia
R7865	T26640	T26636	conj	muscle,epithelia
R7866	T26641	T26640	punct	", ",muscle
R7867	T26642	T26640	cc	and,muscle
R7868	T26643	T26644	compound	lens,fibres
R7869	T26644	T26640	conj	fibres,muscle
R7870	T26645	T26620	punct	),leave
R7871	T26646	T26647	punct	(,reviewed
R7872	T26647	T26620	parataxis	reviewed,leave
R7873	T26648	T26647	prep	in,reviewed
R7874	T26649	T26648	punct	[,in
R7875	T26650	T26648	pobj	66,in
R7876	T26651	T26647	punct	],reviewed
R7877	T26652	T26647	punct	),reviewed
R7878	T26653	T26615	punct	.,is
R7879	T26655	T26656	amod	Early,studies
R7880	T26656	T26658	nsubj	studies,suggested
R7881	T26657	T26656	compound	overexpression,studies
R7882	T26659	T26660	advmod	in,vitro
R7883	T26660	T26656	advmod	vitro,studies
R7884	T26661	T26662	nsubj	Rb,temper
R7885	T26662	T26658	advcl	temper,suggested
R7886	T26663	T26662	aux	might,temper
R7887	T26664	T26662	dobj	expansion,temper
R7888	T26665	T26664	prep	of,expansion
R7889	T26666	T26667	compound	cycling,cells
R7890	T26667	T26665	pobj	cells,of
R7891	T26668	T26658	punct	", ",suggested
R7892	T26669	T26658	cc	but,suggested
R7893	T26670	T26671	compound	KO,studies
R7894	T26671	T26672	nsubj	studies,indicate
R7895	T26672	T26658	conj	indicate,suggested
R7896	T26673	T26674	advmod	in,vivo
R7897	T26674	T26671	advmod	vivo,studies
R7898	T26675	T26676	mark	that,is
R7899	T26676	T26672	ccomp	is,indicate
R7900	T26677	T26678	poss	its,role
R7901	T26678	T26676	nsubj	role,is
R7902	T26679	T26678	amod	major,role
R7903	T26680	T26681	aux	to,block
R7904	T26681	T26676	xcomp	block,is
R7905	T26682	T26681	dobj	division,block
R7906	T26683	T26681	prep	in,block
R7907	T26684	T26685	advmod	terminally,differentiating
R7908	T26685	T26686	amod	differentiating,cells
R7909	T26686	T26683	pobj	cells,in
R7910	T26687	T26672	punct	.,indicate
R7911	T26689	T26690	prep	In,go
R7912	T26691	T26692	poss	its,absence
R7913	T26692	T26689	pobj	absence,In
R7914	T26693	T26690	punct	", ",go
R7915	T26694	T26690	nsubj	many,go
R7916	T26695	T26694	punct	(,many
R7917	T26696	T26694	cc	but,many
R7918	T26697	T26696	advmod	clearly,but
R7919	T26698	T26696	neg	not,but
R7920	T26699	T26700	nmod	all,aspects
R7921	T26700	T26694	conj	aspects,many
R7922	T26701	T26700	punct	),aspects
R7923	T26702	T26694	prep	of,many
R7924	T26703	T26702	pobj	differentiation,of
R7925	T26704	T26690	prt	ahead,go
R7926	T26705	T26706	advmod	relatively,unperturbed
R7927	T26706	T26690	advcl	unperturbed,go
R7928	T26707	T26690	punct	.,go
R7929	T26709	T26710	prep	In,born
R7930	T26711	T26712	det	the,retina
R7931	T26712	T26709	pobj	retina,In
R7932	T26713	T26710	punct	", ",born
R7933	T26714	T26715	amod	differentiating,cells
R7934	T26715	T26710	nsubjpass	cells,born
R7935	T26716	T26715	compound	transition,cells
R7936	T26717	T26710	auxpass	are,born
R7937	T26718	T26710	prep	in,born
R7938	T26719	T26720	det	the,absence
R7939	T26720	T26718	pobj	absence,in
R7940	T26721	T26720	prep	of,absence
R7941	T26722	T26721	pobj	Rb,of
R7942	T26723	T26710	punct	", ",born
R7943	T26724	T26710	conj	migrate,born
R7944	T26725	T26724	prep	to,migrate
R7945	T26726	T26727	det	the,layer
R7946	T26727	T26725	pobj	layer,to
R7947	T26728	T26727	amod	correct,layer
R7948	T26729	T26724	punct	", ",migrate
R7949	T26730	T26724	cc	and,migrate
R7950	T26731	T26724	conj	express,migrate
R7951	T26732	T26733	amod	appropriate,markers
R7952	T26733	T26731	dobj	markers,express
R7953	T26734	T26735	punct	(,2
R7954	T26735	T26731	parataxis	2,express
R7955	T26736	T26735	punct	[,2
R7956	T26737	T26735	punct	],2
R7957	T26738	T26735	cc	and,2
R7958	T26739	T26740	det	this,work
R7959	T26740	T26735	conj	work,2
R7960	T26741	T26740	punct	),work
R7961	T26742	T26710	punct	.,born
R7962	T26744	T26745	prep	In,migrate
R7963	T26746	T26744	pobj	brain,In
R7964	T26747	T26745	punct	", ",migrate
R7965	T26748	T26749	compound	Rb,KO
R7966	T26749	T26750	compound	KO,neurons
R7967	T26750	T26745	nsubj	neurons,migrate
R7968	T26751	T26745	advmod	away,migrate
R7969	T26752	T26751	prep	from,away
R7970	T26753	T26754	det	the,zone
R7971	T26754	T26752	pobj	zone,from
R7972	T26755	T26754	amod	ventricular,zone
R7973	T26756	T26745	cc	and,migrate
R7974	T26757	T26745	conj	switch,migrate
R7975	T26758	T26757	prt	on,switch
R7976	T26759	T26757	dobj	Tubb3,switch
R7977	T26760	T26759	punct	(,Tubb3
R7978	T26761	T26762	compound	βIII,tubulin
R7979	T26762	T26759	appos	tubulin,Tubb3
R7980	T26763	T26762	punct	-,tubulin
R7981	T26764	T26757	punct	),switch
R7982	T26765	T26757	punct	", ",switch
R7983	T26766	T26757	cc	but,switch
R7984	T26767	T26757	conj	continue,switch
R7985	T26768	T26769	aux	to,incorporate
R7986	T26769	T26767	xcomp	incorporate,continue
R7987	T26770	T26769	dobj	BrdU,incorporate
R7988	T26771	T26772	punct	[,13
R7989	T26772	T26769	parataxis	13,incorporate
R7990	T26773	T26772	punct	],13
R7991	T26774	T26745	punct	", ",migrate
R7992	T26775	T26745	cc	and,migrate
R7993	T26776	T26777	prep	in,migrate
R7994	T26777	T26745	conj	migrate,migrate
R7995	T26778	T26779	compound	gut,epithelia
R7996	T26779	T26776	pobj	epithelia,in
R7997	T26780	T26777	punct	", ",migrate
R7998	T26781	T26782	amod	differentiated,enterocytes
R7999	T26782	T26777	nsubj	enterocytes,migrate
R8000	T26783	T26777	prep	up,migrate
R8001	T26784	T26785	det	the,villi
R8002	T26785	T26783	pobj	villi,up
R8003	T26786	T26777	cc	and,migrate
R8004	T26787	T26777	conj	activate,migrate
R8005	T26788	T26787	dobj	expression,activate
R8006	T26789	T26788	prep	of,expression
R8007	T26790	T26789	pobj	serotonin,of
R8008	T26791	T26787	punct	", ",activate
R8009	T26792	T26787	cc	yet,activate
R8010	T26793	T26787	conj	continue,activate
R8011	T26794	T26795	aux	to,incorporate
R8012	T26795	T26793	xcomp	incorporate,continue
R8013	T26796	T26795	dobj	BrdU,incorporate
R8014	T26797	T26798	punct	[,67
R8015	T26798	T26795	parataxis	67,incorporate
R8016	T26799	T26798	punct	],67
R8017	T26800	T26777	punct	.,migrate
R8018	T26802	T26803	prep	In,were
R8019	T26804	T26805	det	the,case
R8020	T26805	T26802	pobj	case,In
R8021	T26806	T26805	prep	of,case
R8022	T26807	T26806	pobj	SACs,of
R8023	T26808	T26803	punct	", ",were
R8024	T26809	T26810	det	the,differentiation
R8025	T26810	T26803	nsubj	differentiation,were
R8026	T26811	T26810	nmod	defects,differentiation
R8027	T26812	T26813	nsubj	we,observed
R8028	T26813	T26810	advcl	observed,differentiation
R8029	T26814	T26810	punct	(,differentiation
R8030	T26815	T26816	advmod	e.g.,loss
R8031	T26816	T26810	appos	loss,differentiation
R8032	T26817	T26816	punct	", ",loss
R8033	T26818	T26816	prep	of,loss
R8034	T26819	T26818	pobj	Slc18a3,of
R8035	T26820	T26819	cc	and,Slc18a3
R8036	T26821	T26819	conj	Chat,Slc18a3
R8037	T26822	T26803	punct	),were
R8038	T26823	T26803	neg	not,were
R8039	T26824	T26803	prep	due,were
R8040	T26825	T26824	pcomp	to,due
R8041	T26826	T26827	amod	aberrant,division
R8042	T26827	T26824	pobj	division,due
R8043	T26828	T26803	punct	", ",were
R8044	T26829	T26803	cc	but,were
R8045	T26830	T26831	nsubj	it,is
R8046	T26831	T26803	conj	is,were
R8047	T26832	T26831	acomp	possible,is
R8048	T26833	T26834	expl	there,are
R8049	T26834	T26831	advcl	are,is
R8050	T26835	T26836	amod	other,problems
R8051	T26836	T26834	attr	problems,are
R8052	T26837	T26836	prep	with,problems
R8053	T26838	T26839	det	these,cells
R8054	T26839	T26837	pobj	cells,with
R8055	T26840	T26841	dep	that,caused
R8056	T26841	T26836	relcl	caused,problems
R8057	T26842	T26841	auxpass	are,caused
R8058	T26843	T26841	agent	by,caused
R8059	T26844	T26845	amod	ectopic,division
R8060	T26845	T26843	pobj	division,by
R8061	T26846	T26831	punct	.,is
R8062	T26848	T26849	advmod	Nevertheless,is
R8063	T26850	T26849	punct	", ",is
R8064	T26851	T26849	nsubj	it,is
R8065	T26852	T26849	acomp	clear,is
R8066	T26853	T26854	mark	that,are
R8067	T26854	T26849	ccomp	are,is
R8068	T26855	T26856	amod	many,aspects
R8069	T26856	T26854	nsubj	aspects,are
R8070	T26857	T26856	prep	of,aspects
R8071	T26858	T26857	pobj	differentiation,of
R8072	T26859	T26856	prep	in,aspects
R8073	T26860	T26861	amod	multiple,types
R8074	T26861	T26859	pobj	types,in
R8075	T26862	T26861	compound	cell,types
R8076	T26863	T26854	acomp	compatible,are
R8077	T26864	T26863	prep	with,compatible
R8078	T26865	T26866	amod	ectopic,division
R8079	T26866	T26864	pobj	division,with
R8080	T26867	T26849	punct	.,is
R8081	T26869	T26870	advmod	However,is
R8082	T26871	T26870	punct	", ",is
R8083	T26872	T26870	nsubj	division,is
R8084	T26873	T26872	prep	of,division
R8085	T26874	T26875	advmod	terminally,differentiating
R8086	T26875	T26876	amod	differentiating,cells
R8087	T26876	T26873	pobj	cells,of
R8088	T26877	T26870	acomp	dangerous,is
R8089	T26878	T26870	punct	", ",is
R8090	T26879	T26880	mark	since,facilitate
R8091	T26880	T26870	advcl	facilitate,is
R8092	T26881	T26880	nsubj	it,facilitate
R8093	T26882	T26880	aux	may,facilitate
R8094	T26883	T26880	dobj	transformation,facilitate
R8095	T26884	T26880	punct	", ",facilitate
R8096	T26885	T26886	mark	as,is
R8097	T26886	T26880	advcl	is,facilitate
R8098	T26887	T26888	det	the,case
R8099	T26888	T26886	attr	case,is
R8100	T26889	T26886	prep	in,is
R8101	T26890	T26889	pobj	retinoblastoma,in
R8102	T26891	T26892	punct	(,reviewed
R8103	T26892	T26886	parataxis	reviewed,is
R8104	T26893	T26892	prep	in,reviewed
R8105	T26894	T26893	punct	[,in
R8106	T26895	T26893	pobj	66,in
R8107	T26896	T26892	punct	],reviewed
R8108	T26897	T26892	punct	),reviewed
R8109	T26898	T26870	punct	.,is
R8110	T27218	T27219	advmod	How,Perturb
R8111	T27220	T27219	aux	Does,Perturb
R8112	T27221	T27219	nsubj	E2f3a,Perturb
R8113	T27222	T27223	compound	SAC,Differentiation
R8114	T27223	T27219	dobj	Differentiation,Perturb
R8115	T27224	T27219	punct	?,Perturb
R8116	T27226	T27227	nsubj	E2f3a,disrupt
R8117	T27228	T27227	aux	could,disrupt
R8118	T27229	T27230	compound	SAC,differentiation
R8119	T27230	T27227	dobj	differentiation,disrupt
R8120	T27231	T27227	prep	through,disrupt
R8121	T27232	T27233	poss	its,role
R8122	T27233	T27231	pobj	role,through
R8123	T27234	T27235	advmod	well,known
R8124	T27235	T27233	amod	known,role
R8125	T27236	T27233	prep	as,role
R8126	T27237	T27238	det	a,activator
R8127	T27238	T27236	pobj	activator,as
R8128	T27239	T27238	amod	transcriptional,activator
R8129	T27240	T27227	punct	", ",disrupt
R8130	T27241	T27227	cc	or,disrupt
R8131	T27242	T27227	punct	", ",disrupt
R8132	T27243	T27244	prep	in,affect
R8133	T27244	T27227	conj	affect,disrupt
R8134	T27245	T27243	pobj	view,in
R8135	T27246	T27245	prep	of,view
R8136	T27247	T27248	det	the,discovery
R8137	T27248	T27246	pobj	discovery,of
R8138	T27249	T27250	mark	that,is
R8139	T27250	T27248	acl	is,discovery
R8140	T27251	T27250	nsubj	it,is
R8141	T27252	T27253	advmod	partially,cytoplasmic
R8142	T27253	T27250	acomp	cytoplasmic,is
R8143	T27254	T27244	punct	", ",affect
R8144	T27255	T27244	nsubj	E2f3a,affect
R8145	T27256	T27244	aux	may,affect
R8146	T27257	T27244	dobj	processes,affect
R8147	T27258	T27257	amod	other,processes
R8148	T27259	T27258	prep	than,other
R8149	T27260	T27261	compound	gene,regulation
R8150	T27261	T27259	pobj	regulation,than
R8151	T27262	T27244	punct	.,affect
R8152	T27264	T27265	det	Both,scenarios
R8153	T27265	T27266	nsubj	scenarios,are
R8154	T27267	T27266	acomp	feasible,are
R8155	T27268	T27269	mark	since,regulate
R8156	T27269	T27266	advcl	regulate,are
R8157	T27270	T27269	nsubj	E2fs,regulate
R8158	T27271	T27272	compound	differentiation,genes
R8159	T27272	T27269	dobj	genes,regulate
R8160	T27273	T27274	punct	[,44
R8161	T27274	T27266	parataxis	44,are
R8162	T27275	T27276	punct	–,48
R8163	T27276	T27274	prep	48,44
R8164	T27277	T27274	punct	],44
R8165	T27278	T27266	punct	", ",are
R8166	T27279	T27266	cc	and,are
R8167	T27280	T27281	compound	cell,cycle
R8168	T27281	T27282	compound	cycle,regulators
R8169	T27282	T27283	nsubj	regulators,have
R8170	T27283	T27266	conj	have,are
R8171	T27284	T27282	punct	", ",regulators
R8172	T27285	T27286	amod	such,as
R8173	T27286	T27282	prep	as,regulators
R8174	T27287	T27286	pobj	Cdkn1b,as
R8175	T27288	T27283	punct	", ",have
R8176	T27289	T27290	amod	cytoplasmic,activities
R8177	T27290	T27283	dobj	activities,have
R8178	T27291	T27292	dep	that,influence
R8179	T27292	T27290	relcl	influence,activities
R8180	T27293	T27292	dobj	differentiation,influence
R8181	T27294	T27295	punct	[,69
R8182	T27295	T27283	parataxis	69,have
R8183	T27296	T27295	nummod	68,69
R8184	T27297	T27295	punct	",",69
R8185	T27298	T27295	punct	],69
R8186	T27299	T27283	punct	.,have
R8187	T27301	T27302	amod	Many,factors
R8188	T27302	T27304	nsubj	factors,shuttle
R8189	T27303	T27302	compound	transcription,factors
R8190	T27305	T27304	prep	between,shuttle
R8191	T27306	T27305	pobj	nucleus,between
R8192	T27307	T27306	cc	and,nucleus
R8193	T27308	T27306	conj	cytoplasm,nucleus
R8194	T27309	T27304	prep	during,shuttle
R8195	T27310	T27309	pobj	neurogenesis,during
R8196	T27311	T27312	punct	(,70
R8197	T27312	T27304	parataxis	70,shuttle
R8198	T27313	T27312	advmod	e.g.,70
R8199	T27314	T27312	punct	", ",70
R8200	T27315	T27312	punct	[,70
R8201	T27316	T27312	punct	],70
R8202	T27317	T27312	cc	and,70
R8203	T27318	T27312	conj	references,70
R8204	T27319	T27318	advmod	therein,references
R8205	T27320	T27312	punct	),70
R8206	T27321	T27304	punct	.,shuttle
R8207	T27323	T27324	nsubj	It,be
R8208	T27325	T27324	aux	may,be
R8209	T27326	T27324	acomp	difficult,be
R8210	T27327	T27328	aux	to,identify
R8211	T27328	T27324	xcomp	identify,be
R8212	T27329	T27330	npadvmod	E2f3a,specific
R8213	T27330	T27332	amod	specific,genes
R8214	T27331	T27330	punct	-,specific
R8215	T27332	T27328	dobj	genes,identify
R8216	T27333	T27332	compound	target,genes
R8217	T27334	T27332	cc	or,genes
R8218	T27335	T27336	amod	cytoplasmic,proteins
R8219	T27336	T27332	conj	proteins,genes
R8220	T27337	T27328	prep	in,identify
R8221	T27338	T27337	pobj	SACs,in
R8222	T27339	T27340	mark	since,are
R8223	T27340	T27324	advcl	are,be
R8224	T27341	T27342	det	these,neurons
R8225	T27342	T27340	nsubj	neurons,are
R8226	T27343	T27344	det	a,proportion
R8227	T27344	T27340	attr	proportion,are
R8228	T27345	T27344	amod	small,proportion
R8229	T27346	T27344	punct	(,proportion
R8230	T27347	T27348	punct	<,1
R8231	T27348	T27349	nummod	1,%
R8232	T27349	T27344	appos	%,proportion
R8233	T27350	T27344	punct	),proportion
R8234	T27351	T27344	prep	of,proportion
R8235	T27352	T27353	det	the,retina
R8236	T27353	T27351	pobj	retina,of
R8237	T27354	T27353	amod	total,retina
R8238	T27355	T27344	cc	and,proportion
R8239	T27356	T27357	advmod	only,5.2
R8240	T27357	T27359	nummod	5.2,%
R8241	T27358	T27357	punct	~,5.2
R8242	T27359	T27344	conj	%,proportion
R8243	T27360	T27359	prep	of,%
R8244	T27361	T27362	amod	amacrine,neurons
R8245	T27362	T27360	pobj	neurons,of
R8246	T27363	T27364	punct	[,38
R8247	T27364	T27340	parataxis	38,are
R8248	T27365	T27364	punct	],38
R8249	T27366	T27324	punct	.,be
R8250	T27794	T27795	aux	Do,Mediate
R8251	T27796	T27795	nsubj	E2fs,Mediate
R8252	T27797	T27798	det	All,Functions
R8253	T27798	T27795	dobj	Functions,Mediate
R8254	T27799	T27798	compound	Rb,Functions
R8255	T27800	T27795	punct	?,Mediate
R8256	T27802	T27803	nsubj	Others,suggested
R8257	T27804	T27803	aux	have,suggested
R8258	T27805	T27806	mark	that,promotes
R8259	T27806	T27803	ccomp	promotes,suggested
R8260	T27807	T27806	nsubj	Rb,promotes
R8261	T27808	T27806	dobj	differentiation,promotes
R8262	T27809	T27806	prep	in,promotes
R8263	T27810	T27811	amod	non-neuronal,cells
R8264	T27811	T27809	pobj	cells,in
R8265	T27812	T27806	prep	through,promotes
R8266	T27813	T27814	npadvmod	E2f,independent
R8267	T27814	T27816	amod	independent,means
R8268	T27815	T27814	punct	-,independent
R8269	T27816	T27812	pobj	means,through
R8270	T27817	T27818	punct	[,31
R8271	T27818	T27803	parataxis	31,suggested
R8272	T27819	T27820	punct	–,33
R8273	T27820	T27818	prep	33,31
R8274	T27821	T27818	punct	],31
R8275	T27822	T27803	punct	.,suggested
R8276	T27824	T27825	advmod	However,assess
R8277	T27826	T27825	punct	", ",assess
R8278	T27827	T27828	det	these,studies
R8279	T27828	T27825	nsubj	studies,assess
R8280	T27829	T27825	aux	did,assess
R8281	T27830	T27825	neg	not,assess
R8282	T27831	T27832	mark	whether,differentiate
R8283	T27832	T27825	ccomp	differentiate,assess
R8284	T27833	T27834	det	these,types
R8285	T27834	T27832	nsubj	types,differentiate
R8286	T27835	T27834	compound	cell,types
R8287	T27836	T27832	advmod	normally,differentiate
R8288	T27837	T27838	mark	if,deleted
R8289	T27838	T27832	advcl	deleted,differentiate
R8290	T27839	T27838	nsubjpass	Rb,deleted
R8291	T27840	T27838	auxpass	is,deleted
R8292	T27841	T27838	prep	along,deleted
R8293	T27842	T27841	prep	with,along
R8294	T27843	T27844	nummod	one,members
R8295	T27844	T27842	pobj	members,with
R8296	T27845	T27843	cc	or,one
R8297	T27846	T27843	conj	more,one
R8298	T27847	T27844	compound	E2f,members
R8299	T27848	T27844	compound	family,members
R8300	T27849	T27825	punct	.,assess
R8301	T27851	T27852	nummod	One,study
R8302	T27852	T27853	nsubj	study,reported
R8303	T27854	T27855	mark	that,induce
R8304	T27855	T27853	ccomp	induce,reported
R8305	T27856	T27857	compound	Rb,mutants
R8306	T27857	T27855	nsubj	mutants,induce
R8307	T27858	T27859	dep	that,bind
R8308	T27859	T27857	relcl	bind,mutants
R8309	T27860	T27859	aux	do,bind
R8310	T27861	T27859	neg	not,bind
R8311	T27862	T27859	dobj	E2f,bind
R8312	T27863	T27855	advmod	still,induce
R8313	T27864	T27855	dobj	differentiation,induce
R8314	T27865	T27866	punct	[,30
R8315	T27866	T27855	parataxis	30,induce
R8316	T27867	T27866	punct	],30
R8317	T27868	T27853	punct	.,reported
R8318	T27870	T27871	advmod	However,performed
R8319	T27872	T27871	punct	", ",performed
R8320	T27873	T27874	det	the,assays
R8321	T27874	T27871	nsubjpass	assays,performed
R8322	T27875	T27874	compound	binding,assays
R8323	T27876	T27871	auxpass	were,performed
R8324	T27877	T27871	prep	in,performed
R8325	T27878	T27877	pobj	solution,in
R8326	T27879	T27871	punct	", ",performed
R8327	T27880	T27871	cc	and,performed
R8328	T27881	T27882	nsubj	we,found
R8329	T27882	T27871	conj	found,performed
R8330	T27883	T27882	aux	have,found
R8331	T27884	T27885	mark	that,bind
R8332	T27885	T27882	ccomp	bind,found
R8333	T27886	T27885	nsubj	several,bind
R8334	T27887	T27886	prep	of,several
R8335	T27888	T27889	det	these,mutants
R8336	T27889	T27887	pobj	mutants,of
R8337	T27890	T27885	aux	do,bind
R8338	T27891	T27885	dobj	E2f,bind
R8339	T27892	T27885	punct	", ",bind
R8340	T27893	T27885	prep	albeit,bind
R8341	T27894	T27893	pcomp	weakly,albeit
R8342	T27895	T27885	punct	", ",bind
R8343	T27896	T27885	prep	on,bind
R8344	T27897	T27896	pobj	chromatin,on
R8345	T27898	T27899	punct	(,T.
R8346	T27899	T27885	meta	T.,bind
R8347	T27900	T27899	nmod	Yu,T.
R8348	T27901	T27899	cc	and,T.
R8349	T27902	T27899	conj	R.,T.
R8350	T27903	T27902	nmod	B.,R.
R8351	T27904	T27902	punct	", ",R.
R8352	T27905	T27906	amod	unpublished,data
R8353	T27906	T27902	conj	data,R.
R8354	T27907	T27906	punct	),data
R8355	T27908	T27882	punct	.,found
R8356	T27910	T27911	nsubj	It,is
R8357	T27912	T27911	acomp	possible,is
R8358	T27913	T27914	mark	that,be
R8359	T27914	T27911	advcl	be,is
R8360	T27915	T27916	npadvmod	Rb,mediated
R8361	T27916	T27918	amod	mediated,potentiation
R8362	T27917	T27916	punct	-,mediated
R8363	T27918	T27914	nsubj	potentiation,be
R8364	T27919	T27918	prep	of,potentiation
R8365	T27920	T27921	npadvmod	tissue,specific
R8366	T27921	T27923	amod	specific,factors
R8367	T27922	T27921	punct	-,specific
R8368	T27923	T27919	pobj	factors,of
R8369	T27924	T27923	compound	transcription,factors
R8370	T27925	T27914	aux	may,be
R8371	T27926	T27914	punct	", ",be
R8372	T27927	T27928	advmod	at,least
R8373	T27928	T27929	advmod	least,in
R8374	T27929	T27914	prep	in,be
R8375	T27930	T27931	det	some,cases
R8376	T27931	T27929	pobj	cases,in
R8377	T27932	T27914	punct	", ",be
R8378	T27933	T27934	det	a,activity
R8379	T27934	T27914	attr	activity,be
R8380	T27935	T27934	amod	redundant,activity
R8381	T27936	T27914	punct	", ",be
R8382	T27937	T27914	cc	and,be
R8383	T27938	T27939	mark	that,is
R8384	T27939	T27914	conj	is,be
R8385	T27940	T27941	det	the,function
R8386	T27941	T27939	nsubj	function,is
R8387	T27942	T27941	amod	only,function
R8388	T27943	T27941	amod	critical,function
R8389	T27944	T27941	compound	Rb,function
R8390	T27945	T27946	aux	to,inhibit
R8391	T27946	T27939	xcomp	inhibit,is
R8392	T27947	T27946	dobj	E2f,inhibit
R8393	T27948	T27911	punct	.,is
R8394	T27950	T27951	poss	Our,study
R8395	T27951	T27952	nsubj	study,is
R8396	T27953	T27954	det	the,first
R8397	T27954	T27952	attr	first,is
R8398	T27955	T27954	prep	to,first
R8399	T27956	T27957	poss	our,knowledge
R8400	T27957	T27955	pobj	knowledge,to
R8401	T27958	T27959	aux	to,assess
R8402	T27959	T27954	advcl	assess,first
R8403	T27960	T27959	advmod	comprehensively,assess
R8404	T27961	T27962	mark	whether,differentiate
R8405	T27962	T27959	ccomp	differentiate,assess
R8406	T27963	T27964	compound	Rb,KO
R8407	T27964	T27965	compound	KO,cells
R8408	T27965	T27962	nsubj	cells,differentiate
R8409	T27966	T27962	aux	can,differentiate
R8410	T27967	T27962	prep	in,differentiate
R8411	T27968	T27969	det	the,absence
R8412	T27969	T27967	pobj	absence,in
R8413	T27970	T27969	prep	of,absence
R8414	T27971	T27972	amod	different,E2fs
R8415	T27972	T27970	pobj	E2fs,of
R8416	T27973	T27952	punct	.,is
R8417	T27975	T27976	prep	In,be
R8418	T27977	T27975	pobj	light,In
R8419	T27978	T27977	prep	of,light
R8420	T27979	T27980	poss	our,findings
R8421	T27980	T27978	pobj	findings,of
R8422	T27981	T27976	punct	", ",be
R8423	T27982	T27976	nsubj	it,be
R8424	T27983	T27976	aux	will,be
R8425	T27984	T27976	acomp	important,be
R8426	T27985	T27986	aux	to,reassess
R8427	T27986	T27976	xcomp	reassess,be
R8428	T27987	T27988	compound	differentiation,defects
R8429	T27988	T27986	dobj	defects,reassess
R8430	T27989	T27988	prep	in,defects
R8431	T27990	T27991	amod	other,tissues
R8432	T27991	T27989	pobj	tissues,in
R8433	T27992	T27993	compound	Rb,KO
R8434	T27993	T27991	compound	KO,tissues
R8435	T27994	T27986	prep	in,reassess
R8436	T27995	T27996	det	the,absence
R8437	T27996	T27994	pobj	absence,in
R8438	T27997	T27996	prep	of,absence
R8439	T27998	T27999	amod	individual,members
R8440	T27999	T27997	pobj	members,of
R8441	T28000	T27998	cc	and,individual
R8442	T28001	T27998	conj	combined,individual
R8443	T28002	T27999	amod	activating,members
R8444	T28003	T27999	compound	E2f,members
R8445	T28004	T27999	compound	family,members
R8446	T28005	T27976	punct	.,be
R8447	T28375	T28376	compound	Mouse,strains
R8448	T28377	T28376	cc	and,strains
R8449	T28378	T28376	conj	genotyping,strains
R8450	T28379	T28378	punct	.,genotyping
R8451	T28381	T28382	nsubjpass	Mice,treated
R8452	T28383	T28382	auxpass	were,treated
R8453	T28384	T28382	prep	according,treated
R8454	T28385	T28384	prep	to,according
R8455	T28386	T28387	amod	institutional,guidelines
R8456	T28387	T28385	pobj	guidelines,to
R8457	T28388	T28386	cc	and,institutional
R8458	T28389	T28386	conj	national,institutional
R8459	T28390	T28382	punct	.,treated
R8460	T28392	T28393	compound	α,Cre
R8461	T28393	T28395	compound	Cre,mice
R8462	T28394	T28393	punct	-,Cre
R8463	T28395	T28396	nsubjpass	mice,maintained
R8464	T28397	T28398	punct	(,Gruss
R8465	T28398	T28395	parataxis	Gruss,mice
R8466	T28399	T28398	compound	P.,Gruss
R8467	T28400	T28398	punct	),Gruss
R8468	T28401	T28395	punct	", ",mice
R8469	T28402	T28403	compound	Chx10,Cre
R8470	T28403	T28405	compound	Cre,mice
R8471	T28404	T28403	punct	-,Cre
R8472	T28405	T28395	conj	mice,mice
R8473	T28406	T28407	punct	(,Cepko
R8474	T28407	T28405	parataxis	Cepko,mice
R8475	T28408	T28407	compound	C.,Cepko
R8476	T28409	T28407	punct	),Cepko
R8477	T28410	T28405	punct	", ",mice
R8478	T28411	T28412	compound	RbloxP,loxP
R8479	T28412	T28414	compound	loxP,mice
R8480	T28413	T28412	punct	/,loxP
R8481	T28414	T28405	conj	mice,mice
R8482	T28415	T28416	punct	(,Berns
R8483	T28416	T28414	parataxis	Berns,mice
R8484	T28417	T28416	compound	A.,Berns
R8485	T28418	T28416	punct	),Berns
R8486	T28419	T28414	punct	", ",mice
R8487	T28420	T28421	nmod	E2f1,mice
R8488	T28421	T28414	conj	mice,mice
R8489	T28422	T28420	punct	–,E2f1
R8490	T28423	T28420	punct	/,E2f1
R8491	T28424	T28420	punct	–,E2f1
R8492	T28425	T28421	punct	", ",mice
R8493	T28426	T28427	nmod	E2f2,mice
R8494	T28427	T28421	conj	mice,mice
R8495	T28428	T28426	punct	–,E2f2
R8496	T28429	T28426	punct	/,E2f2
R8497	T28430	T28426	punct	–,E2f2
R8498	T28431	T28427	punct	", ",mice
R8499	T28432	T28433	compound	E2f3loxP,loxP
R8500	T28433	T28435	compound	loxP,mice
R8501	T28434	T28433	punct	/,loxP
R8502	T28435	T28427	conj	mice,mice
R8503	T28436	T28435	punct	", ",mice
R8504	T28437	T28435	cc	and,mice
R8505	T28438	T28439	nmod	E2f3a,mice
R8506	T28439	T28435	conj	mice,mice
R8507	T28440	T28438	punct	−,E2f3a
R8508	T28441	T28438	punct	/,E2f3a
R8509	T28442	T28438	punct	−,E2f3a
R8510	T28443	T28396	auxpass	were,maintained
R8511	T28444	T28396	prep	on,maintained
R8512	T28445	T28446	det	a,background
R8513	T28446	T28444	pobj	background,on
R8514	T28447	T28446	amod	mixed,background
R8515	T28448	T28446	punct	(,background
R8516	T28449	T28450	nmod	NMRI,C57
R8517	T28450	T28446	nmod	C57,background
R8518	T28451	T28450	punct	×,C57
R8519	T28452	T28450	punct	/,C57
R8520	T28453	T28454	nmod	Bl,FVB
R8521	T28454	T28450	appos	FVB,C57
R8522	T28455	T28454	punct	×,FVB
R8523	T28456	T28450	punct	/,C57
R8524	T28457	T28458	nmod	N,129sv
R8525	T28458	T28450	appos	129sv,C57
R8526	T28459	T28458	punct	×,129sv
R8527	T28460	T28446	punct	),background
R8528	T28461	T28396	punct	.,maintained
R8529	T28463	T28464	det	A,description
R8530	T28464	T28466	nsubjpass	description,published
R8531	T28465	T28464	amod	detailed,description
R8532	T28467	T28464	prep	of,description
R8533	T28468	T28469	nmod	E2f3a,mice
R8534	T28469	T28467	pobj	mice,of
R8535	T28470	T28468	punct	−,E2f3a
R8536	T28471	T28468	punct	/,E2f3a
R8537	T28472	T28468	punct	−,E2f3a
R8538	T28473	T28466	aux	will,published
R8539	T28474	T28466	auxpass	be,published
R8540	T28475	T28466	advmod	elsewhere,published
R8541	T28476	T28466	punct	.,published
R8542	T28478	T28479	nsubjpass	Mice,compared
R8543	T28480	T28478	prep	of,Mice
R8544	T28481	T28482	amod	different,genotypes
R8545	T28482	T28480	pobj	genotypes,of
R8546	T28483	T28479	auxpass	were,compared
R8547	T28484	T28479	prep	within,compared
R8548	T28485	T28486	det	the,litter
R8549	T28486	T28484	pobj	litter,within
R8550	T28487	T28486	amod	same,litter
R8551	T28488	T28484	cc	and,within
R8552	T28489	T28484	conj	across,within
R8553	T28490	T28491	det	a,minimum
R8554	T28491	T28489	pobj	minimum,across
R8555	T28492	T28491	prep	of,minimum
R8556	T28493	T28494	nummod	three,litters
R8557	T28494	T28492	pobj	litters,of
R8558	T28495	T28479	punct	.,compared
R8559	T28497	T28498	nsubj	We,noted
R8560	T28499	T28498	aux	have,noted
R8561	T28500	T28498	neg	not,noted
R8562	T28501	T28502	det	any,differences
R8563	T28502	T28498	dobj	differences,noted
R8564	T28503	T28502	amod	phenotypic,differences
R8565	T28504	T28502	prep	in,differences
R8566	T28505	T28506	amod	separate,litters
R8567	T28506	T28504	pobj	litters,in
R8568	T28507	T28498	punct	.,noted
R8569	T28509	T28510	nsubjpass	Genotyping,performed
R8570	T28511	T28510	auxpass	was,performed
R8571	T28512	T28510	prep	as,performed
R8572	T28513	T28512	pcomp	before,as
R8573	T28514	T28515	punct	[,5
R8574	T28515	T28510	parataxis	5,performed
R8575	T28516	T28515	nummod	2,5
R8576	T28517	T28515	punct	",",5
R8577	T28518	T28515	punct	],5
R8578	T28519	T28510	punct	", ",performed
R8579	T28520	T28510	cc	and,performed
R8580	T28521	T28522	det	the,primers
R8581	T28522	T28523	nsubj	primers,were
R8582	T28523	T28510	conj	were,performed
R8583	T28524	T28522	acl	used,primers
R8584	T28525	T28524	prep	for,used
R8585	T28526	T28525	pcomp	genotyping,for
R8586	T28527	T28528	nmod	E2f3a,mice
R8587	T28528	T28526	dobj	mice,genotyping
R8588	T28529	T28527	punct	−,E2f3a
R8589	T28530	T28527	punct	/,E2f3a
R8590	T28531	T28527	punct	−,E2f3a
R8591	T28532	T28533	compound	E2f3a,KL
R8592	T28533	T28523	attr	KL,were
R8593	T28534	T28533	punct	(,KL
R8594	T28535	T28536	nummod	5,CTCCAGACCCCCGATTATTT
R8595	T28536	T28533	appos	CTCCAGACCCCCGATTATTT,KL
R8596	T28537	T28535	punct	′,5
R8597	T28538	T28536	punct	-,CTCCAGACCCCCGATTATTT
R8598	T28539	T28536	punct	-,CTCCAGACCCCCGATTATTT
R8599	T28540	T28536	nummod	3,CTCCAGACCCCCGATTATTT
R8600	T28541	T28536	punct	′,CTCCAGACCCCCGATTATTT
R8601	T28542	T28533	punct	),KL
R8602	T28543	T28533	punct	", ",KL
R8603	T28544	T28545	compound	E2f3a,KR1
R8604	T28545	T28533	conj	KR1,KL
R8605	T28546	T28545	punct	(,KR1
R8606	T28547	T28548	nummod	5,TCCAGTGCACTACTCCCTCC
R8607	T28548	T28545	appos	TCCAGTGCACTACTCCCTCC,KR1
R8608	T28549	T28547	punct	′,5
R8609	T28550	T28548	punct	-,TCCAGTGCACTACTCCCTCC
R8610	T28551	T28548	punct	-,TCCAGTGCACTACTCCCTCC
R8611	T28552	T28548	nummod	3,TCCAGTGCACTACTCCCTCC
R8612	T28553	T28548	punct	′,TCCAGTGCACTACTCCCTCC
R8613	T28554	T28545	punct	),KR1
R8614	T28555	T28545	punct	", ",KR1
R8615	T28556	T28545	cc	and,KR1
R8616	T28557	T28558	compound	E2f3a,KM
R8617	T28558	T28545	conj	KM,KR1
R8618	T28559	T28558	punct	(,KM
R8619	T28560	T28561	nummod	5,GCTAGCAGTGCCCTTTTGTC
R8620	T28561	T28558	appos	GCTAGCAGTGCCCTTTTGTC,KM
R8621	T28562	T28560	punct	′,5
R8622	T28563	T28561	punct	-,GCTAGCAGTGCCCTTTTGTC
R8623	T28564	T28561	punct	-,GCTAGCAGTGCCCTTTTGTC
R8624	T28565	T28561	nummod	3,GCTAGCAGTGCCCTTTTGTC
R8625	T28566	T28561	punct	′,GCTAGCAGTGCCCTTTTGTC
R8626	T28567	T28523	punct	),were
R8627	T28568	T28523	punct	.,were
R8628	T29642	T29641	punct	", ",Histology
R8629	T29643	T29641	conj	immunofluorescence,Histology
R8630	T29644	T29643	punct	", ",immunofluorescence
R8631	T29645	T29643	cc	and,immunofluorescence
R8632	T29646	T29643	conj	measurements,immunofluorescence
R8633	T29647	T29646	punct	.,measurements
R8634	T29649	T29650	nsubjpass	Eyeballs,fixed
R8635	T29651	T29650	auxpass	were,fixed
R8636	T29652	T29650	prep	in,fixed
R8637	T29653	T29654	nummod	4,%
R8638	T29654	T29655	compound	%,paraformaldehyde
R8639	T29655	T29652	pobj	paraformaldehyde,in
R8640	T29656	T29650	prep	for,fixed
R8641	T29657	T29658	nummod	1,h
R8642	T29658	T29656	pobj	h,for
R8643	T29659	T29650	prep	at,fixed
R8644	T29660	T29661	nummod	4,°C
R8645	T29661	T29659	pobj	°C,at
R8646	T29662	T29650	punct	", ",fixed
R8647	T29663	T29650	conj	embedded,fixed
R8648	T29664	T29663	prep	in,embedded
R8649	T29665	T29664	pobj	OCT,in
R8650	T29666	T29665	punct	(,OCT
R8651	T29667	T29665	appos	TissueTek,OCT
R8652	T29668	T29667	nummod	4583,TissueTek
R8653	T29669	T29670	punct	", ",Sakura
R8654	T29670	T29665	parataxis	Sakura,OCT
R8655	T29671	T29670	punct	", ",Sakura
R8656	T29672	T29670	npadvmod	http://www.sakuraeu.com,Sakura
R8657	T29673	T29670	punct	),Sakura
R8658	T29674	T29663	punct	", ",embedded
R8659	T29675	T29663	conj	frozen,embedded
R8660	T29676	T29675	prep	on,frozen
R8661	T29677	T29678	amod	dry,ice
R8662	T29678	T29676	pobj	ice,on
R8663	T29679	T29675	punct	", ",frozen
R8664	T29680	T29675	cc	and,frozen
R8665	T29681	T29675	conj	cut,frozen
R8666	T29682	T29681	prep	into,cut
R8667	T29683	T29684	nummod	12,μm
R8668	T29684	T29686	compound	μm,sections
R8669	T29685	T29684	punct	-,μm
R8670	T29686	T29682	pobj	sections,into
R8671	T29687	T29686	prep	on,sections
R8672	T29688	T29689	nmod	Superfrost,slides
R8673	T29689	T29687	pobj	slides,on
R8674	T29690	T29688	cc	plus,Superfrost
R8675	T29691	T29692	punct	(,VWR
R8676	T29692	T29689	parataxis	VWR,slides
R8677	T29693	T29692	punct	", ",VWR
R8678	T29694	T29692	npadvmod	http://www.vwr.com,VWR
R8679	T29695	T29692	punct	),VWR
R8680	T29696	T29650	punct	.,fixed
R8681	T29698	T29699	prep	For,injected
R8682	T29700	T29701	compound	S,phase
R8683	T29701	T29703	compound	phase,analysis
R8684	T29702	T29701	punct	-,phase
R8685	T29703	T29698	pobj	analysis,For
R8686	T29704	T29699	punct	", ",injected
R8687	T29705	T29699	nsubjpass	BrdU,injected
R8688	T29706	T29705	punct	(,BrdU
R8689	T29707	T29708	nummod	100,μg
R8690	T29708	T29705	npadvmod	μg,BrdU
R8691	T29709	T29710	punct	/,g
R8692	T29710	T29708	prep	g,μg
R8693	T29711	T29710	prep	of,g
R8694	T29712	T29713	compound	body,weight
R8695	T29713	T29711	pobj	weight,of
R8696	T29714	T29699	punct	),injected
R8697	T29715	T29699	auxpass	was,injected
R8698	T29716	T29699	advmod	intraperitoneally,injected
R8699	T29717	T29718	nummod	2,h
R8700	T29718	T29719	npadvmod	h,to
R8701	T29719	T29699	prep	to,injected
R8702	T29720	T29719	amod	prior,to
R8703	T29721	T29719	pobj	sacrifice,to
R8704	T29722	T29699	punct	.,injected
R8705	T29724	T29725	nmod	BrdU,cells
R8706	T29725	T29727	nsubjpass	cells,detected
R8707	T29726	T29724	punct	+,BrdU
R8708	T29728	T29727	auxpass	were,detected
R8709	T29729	T29727	advcl	using,detected
R8710	T29730	T29731	det	a,antibody
R8711	T29731	T29729	dobj	antibody,using
R8712	T29732	T29733	npadvmod	biotin,conjugated
R8713	T29733	T29731	amod	conjugated,antibody
R8714	T29734	T29733	punct	-,conjugated
R8715	T29735	T29731	nmod	sheep,antibody
R8716	T29736	T29731	amod	polyclonal,antibody
R8717	T29737	T29738	punct	(,Services
R8718	T29738	T29729	parataxis	Services,using
R8719	T29739	T29738	dep	1,Services
R8720	T29740	T29741	punct	:,500
R8721	T29741	T29739	prep	500,1
R8722	T29742	T29738	punct	", ",Services
R8723	T29743	T29738	compound	Maine,Services
R8724	T29744	T29738	compound	Biotechnology,Services
R8725	T29745	T29738	punct	", ",Services
R8726	T29746	T29738	npadvmod	http://www.mainebiotechnology.com,Services
R8727	T29747	T29738	punct	),Services
R8728	T29748	T29727	punct	.,detected
R8729	T29750	T29751	det	All,antibodies
R8730	T29751	T29753	nsubjpass	antibodies,described
R8731	T29752	T29751	amod	other,antibodies
R8732	T29754	T29753	auxpass	are,described
R8733	T29755	T29753	prep	in,described
R8734	T29756	T29757	compound	Table,S1
R8735	T29757	T29755	pobj	S1,in
R8736	T29758	T29753	punct	.,described
R8737	T29760	T29761	prep	For,performed
R8738	T29762	T29763	nmod	E2f3,staining
R8739	T29763	T29760	pobj	staining,For
R8740	T29764	T29762	punct	", ",E2f3
R8741	T29765	T29762	conj	Mki67,E2f3
R8742	T29766	T29765	punct	", ",Mki67
R8743	T29767	T29765	cc	and,Mki67
R8744	T29768	T29765	conj	Rb,Mki67
R8745	T29769	T29761	punct	", ",performed
R8746	T29770	T29771	compound	antigen,retrieval
R8747	T29771	T29761	nsubjpass	retrieval,performed
R8748	T29772	T29761	auxpass	was,performed
R8749	T29773	T29761	prep	by,performed
R8750	T29774	T29773	pcomp	boiling,by
R8751	T29775	T29774	dobj	sections,boiling
R8752	T29776	T29774	prep	in,boiling
R8753	T29777	T29778	amod	citric,acid
R8754	T29778	T29779	compound	acid,solution
R8755	T29779	T29776	pobj	solution,in
R8756	T29780	T29774	prep	for,boiling
R8757	T29781	T29782	nummod	15,min
R8758	T29782	T29780	pobj	min,for
R8759	T29783	T29774	prep	according,boiling
R8760	T29784	T29783	prep	to,according
R8761	T29785	T29784	pobj	Ino,to
R8762	T29786	T29787	punct	[,50
R8763	T29787	T29785	parataxis	50,Ino
R8764	T29788	T29787	punct	],50
R8765	T29789	T29774	punct	", ",boiling
R8766	T29790	T29774	prep	except,boiling
R8767	T29791	T29790	prep	on,except
R8768	T29792	T29793	amod	frozen,sections
R8769	T29793	T29791	pobj	sections,on
R8770	T29794	T29761	punct	.,performed
R8771	T29796	T29797	nsubjpass	TUNEL,performed
R8772	T29798	T29797	auxpass	was,performed
R8773	T29799	T29800	mark	as,described
R8774	T29800	T29797	advcl	described,performed
R8775	T29801	T29802	punct	[,13
R8776	T29802	T29800	parataxis	13,described
R8777	T29803	T29802	punct	],13
R8778	T29804	T29797	punct	.,performed
R8779	T29806	T29807	advmod	Briefly,incubated
R8780	T29808	T29807	punct	", ",incubated
R8781	T29809	T29807	nsubjpass	sections,incubated
R8782	T29810	T29807	auxpass	were,incubated
R8783	T29811	T29807	prep	for,incubated
R8784	T29812	T29813	nummod	1,h
R8785	T29813	T29811	pobj	h,for
R8786	T29814	T29807	prep	at,incubated
R8787	T29815	T29816	nummod	37,°C
R8788	T29816	T29814	pobj	°C,at
R8789	T29817	T29807	prep	with,incubated
R8790	T29818	T29819	nummod	75,μl
R8791	T29819	T29817	pobj	μl,with
R8792	T29820	T29819	prep	of,μl
R8793	T29821	T29822	compound	mixture,solution
R8794	T29822	T29820	pobj	solution,of
R8795	T29823	T29819	acl	consisting,μl
R8796	T29824	T29823	prep	of,consisting
R8797	T29825	T29826	nummod	0.5,μl
R8798	T29826	T29824	pobj	μl,of
R8799	T29827	T29826	prep	of,μl
R8800	T29828	T29829	amod	terminal,transferase
R8801	T29829	T29827	pobj	transferase,of
R8802	T29830	T29829	compound	deoxynucleotide,transferase
R8803	T29831	T29826	punct	", ",μl
R8804	T29832	T29833	nummod	1,μl
R8805	T29833	T29826	conj	μl,μl
R8806	T29834	T29833	prep	of,μl
R8807	T29835	T29836	nmod	biotin,dUTP
R8808	T29836	T29834	pobj	dUTP,of
R8809	T29837	T29836	punct	-,dUTP
R8810	T29838	T29836	nummod	16,dUTP
R8811	T29839	T29836	punct	-,dUTP
R8812	T29840	T29833	punct	", ",μl
R8813	T29841	T29842	nummod	7.5,μl
R8814	T29842	T29833	conj	μl,μl
R8815	T29843	T29842	prep	of,μl
R8816	T29844	T29843	pobj	CoCl2,of
R8817	T29845	T29842	punct	", ",μl
R8818	T29846	T29847	nummod	15,μl
R8819	T29847	T29842	conj	μl,μl
R8820	T29848	T29847	prep	of,μl
R8821	T29849	T29850	nummod	5,buffer
R8822	T29850	T29848	pobj	buffer,of
R8823	T29851	T29849	punct	×,5
R8824	T29852	T29853	amod	terminal,transferase
R8825	T29853	T29850	compound	transferase,buffer
R8826	T29854	T29853	compound	deoxynucleotide,transferase
R8827	T29855	T29847	punct	", ",μl
R8828	T29856	T29847	cc	and,μl
R8829	T29857	T29858	nummod	51,μl
R8830	T29858	T29847	conj	μl,μl
R8831	T29859	T29858	prep	of,μl
R8832	T29860	T29861	amod	distilled,water
R8833	T29861	T29859	pobj	water,of
R8834	T29862	T29807	punct	.,incubated
R8835	T29864	T29865	prep	After,incubated
R8836	T29866	T29867	nummod	three,washes
R8837	T29867	T29864	pobj	washes,After
R8838	T29868	T29867	prep	in,washes
R8839	T29869	T29870	nummod	4,buffer
R8840	T29870	T29868	pobj	buffer,in
R8841	T29871	T29869	punct	×,4
R8842	T29872	T29870	compound	SSC,buffer
R8843	T29873	T29865	punct	", ",incubated
R8844	T29874	T29865	nsubjpass	sections,incubated
R8845	T29875	T29865	auxpass	were,incubated
R8846	T29876	T29865	prep	with,incubated
R8847	T29877	T29878	nmod	Alexa,streptavidin
R8848	T29878	T29876	pobj	streptavidin,with
R8849	T29879	T29877	nummod	488,Alexa
R8850	T29880	T29877	punct	–,Alexa
R8851	T29881	T29877	cc	or,Alexa
R8852	T29882	T29877	conj	Alexa,Alexa
R8853	T29883	T29882	nummod	568,Alexa
R8854	T29884	T29878	punct	−,streptavidin
R8855	T29885	T29886	punct	(,Probes
R8856	T29886	T29878	parataxis	Probes,streptavidin
R8857	T29887	T29886	dep	1,Probes
R8858	T29888	T29889	punct	:,"1,000"
R8859	T29889	T29887	prep	"1,000",1
R8860	T29890	T29886	punct	;,Probes
R8861	T29891	T29886	compound	Molecular,Probes
R8862	T29892	T29886	punct	", ",Probes
R8863	T29893	T29886	npadvmod	http://probes.invitrogen.com,Probes
R8864	T29894	T29886	punct	),Probes
R8865	T29895	T29865	prep	for,incubated
R8866	T29896	T29897	nummod	1,h
R8867	T29897	T29895	pobj	h,for
R8868	T29898	T29865	prep	at,incubated
R8869	T29899	T29900	compound	room,temperature
R8870	T29900	T29898	pobj	temperature,at
R8871	T29901	T29865	punct	.,incubated
R8872	T29903	T29904	amod	Primary,antibodies
R8873	T29904	T29905	nsubjpass	antibodies,visualized
R8874	T29906	T29904	cc	or,antibodies
R8875	T29907	T29908	amod	labelled,cells
R8876	T29908	T29904	conj	cells,antibodies
R8877	T29909	T29905	auxpass	were,visualized
R8878	T29910	T29905	advcl	using,visualized
R8879	T29911	T29912	nmod	donkey,Alexa
R8880	T29912	T29910	dobj	Alexa,using
R8881	T29913	T29912	amod	anti-mouse,Alexa
R8882	T29914	T29912	nummod	488,Alexa
R8883	T29915	T29912	cc	or,Alexa
R8884	T29916	T29912	conj	Alexa,Alexa
R8885	T29917	T29916	nummod	568,Alexa
R8886	T29918	T29912	punct	", ",Alexa
R8887	T29919	T29920	nmod	donkey,Alexa
R8888	T29920	T29912	conj	Alexa,Alexa
R8889	T29921	T29920	amod	anti-rabbit,Alexa
R8890	T29922	T29920	nummod	488,Alexa
R8891	T29923	T29920	cc	or,Alexa
R8892	T29924	T29920	conj	Alexa,Alexa
R8893	T29925	T29924	nummod	568,Alexa
R8894	T29926	T29920	punct	", ",Alexa
R8895	T29927	T29928	nmod	donkey,Alexa
R8896	T29928	T29920	conj	Alexa,Alexa
R8897	T29929	T29928	amod	anti-goat,Alexa
R8898	T29930	T29928	nummod	488,Alexa
R8899	T29931	T29928	cc	or,Alexa
R8900	T29932	T29928	conj	Alexa,Alexa
R8901	T29933	T29932	nummod	568,Alexa
R8902	T29934	T29928	punct	", ",Alexa
R8903	T29935	T29928	cc	and,Alexa
R8904	T29936	T29937	compound	streptavidin,Alexa
R8905	T29937	T29928	conj	Alexa,Alexa
R8906	T29938	T29937	nummod	488,Alexa
R8907	T29939	T29937	cc	or,Alexa
R8908	T29940	T29937	conj	Alexa,Alexa
R8909	T29941	T29940	nummod	568,Alexa
R8910	T29942	T29943	punct	(,Probes
R8911	T29943	T29910	parataxis	Probes,using
R8912	T29944	T29943	dep	1,Probes
R8913	T29945	T29946	punct	:,"1,000"
R8914	T29946	T29944	prep	"1,000",1
R8915	T29947	T29943	punct	;,Probes
R8916	T29948	T29943	compound	Molecular,Probes
R8917	T29949	T29943	punct	),Probes
R8918	T29950	T29905	punct	.,visualized
R8919	T29952	T29953	nsubjpass	Nuclei,stained
R8920	T29954	T29953	auxpass	were,stained
R8921	T29955	T29953	advmod	counter,stained
R8922	T29956	T29953	punct	-,stained
R8923	T29957	T29953	prep	with,stained
R8924	T29958	T29959	nummod	4,diamidino
R8925	T29959	T29963	nmod	diamidino,phenyindole
R8926	T29960	T29959	punct	",",diamidino
R8927	T29961	T29959	nummod	6,diamidino
R8928	T29962	T29959	punct	-,diamidino
R8929	T29963	T29957	pobj	phenyindole,with
R8930	T29964	T29963	punct	-,phenyindole
R8931	T29965	T29963	nummod	2,phenyindole
R8932	T29966	T29963	punct	-,phenyindole
R8933	T29967	T29963	punct	(,phenyindole
R8934	T29968	T29963	appos	DAPI,phenyindole
R8935	T29969	T29970	punct	;,Sigma
R8936	T29970	T29963	parataxis	Sigma,phenyindole
R8937	T29971	T29970	punct	", ",Sigma
R8938	T29972	T29970	npadvmod	http://www.sigmaaldrich.com,Sigma
R8939	T29973	T29970	punct	),Sigma
R8940	T29974	T29953	punct	.,stained
R8941	T29976	T29977	amod	Labelled,cells
R8942	T29977	T29978	nsubjpass	cells,visualized
R8943	T29979	T29978	auxpass	were,visualized
R8944	T29980	T29978	advcl	using,visualized
R8945	T29981	T29982	det	a,microscope
R8946	T29982	T29980	dobj	microscope,using
R8947	T29983	T29982	nmod	Zeiss,microscope
R8948	T29984	T29983	punct	(,Zeiss
R8949	T29985	T29983	appos	http://www.zeiss.com,Zeiss
R8950	T29986	T29982	punct	),microscope
R8951	T29987	T29982	nmod	Axioplan,microscope
R8952	T29988	T29987	punct	-,Axioplan
R8953	T29989	T29987	nummod	2,Axioplan
R8954	T29990	T29982	prep	with,microscope
R8955	T29991	T29992	compound	Plan,Neofluar
R8956	T29992	T29993	compound	Neofluar,objectives
R8957	T29993	T29990	pobj	objectives,with
R8958	T29994	T29978	cc	and,visualized
R8959	T29995	T29996	nsubj	images,captured
R8960	T29996	T29978	conj	captured,visualized
R8961	T29997	T29996	prep	with,captured
R8962	T29998	T29999	det	a,camera
R8963	T29999	T29997	pobj	camera,with
R8964	T30000	T30001	compound	Zeiss,AxionCam
R8965	T30001	T29999	compound	AxionCam,camera
R8966	T30002	T29996	punct	.,captured
R8967	T30004	T30005	prep	For,obtained
R8968	T30006	T30007	amod	double,labelled
R8969	T30007	T30009	amod	labelled,samples
R8970	T30008	T30007	punct	-,labelled
R8971	T30009	T30004	pobj	samples,For
R8972	T30010	T30005	punct	", ",obtained
R8973	T30011	T30012	amod	confocal,images
R8974	T30012	T30005	nsubjpass	images,obtained
R8975	T30013	T30005	auxpass	were,obtained
R8976	T30014	T30005	prep	with,obtained
R8977	T30015	T30016	det	a,microscope
R8978	T30016	T30014	pobj	microscope,with
R8979	T30017	T30018	nmod	Zeiss,LSM
R8980	T30018	T30016	nmod	LSM,microscope
R8981	T30019	T30018	nummod	5.0,LSM
R8982	T30020	T30021	compound	laser,scanning
R8983	T30021	T30016	compound	scanning,microscope
R8984	T30022	T30005	punct	.,obtained
R8985	T30024	T30025	det	The,retina
R8986	T30025	T30026	nsubjpass	retina,separated
R8987	T30027	T30026	auxpass	was,separated
R8988	T30028	T30026	prep	into,separated
R8989	T30029	T30030	nummod	three,bins
R8990	T30030	T30028	pobj	bins,into
R8991	T30031	T30026	prep	by,separated
R8992	T30032	T30031	pcomp	dividing,by
R8993	T30033	T30034	det	the,edge
R8994	T30034	T30032	dobj	edge,dividing
R8995	T30035	T30034	amod	ventricular,edge
R8996	T30036	T30034	prep	of,edge
R8997	T30037	T30038	det	the,retina
R8998	T30038	T30036	pobj	retina,of
R8999	T30039	T30032	prep	into,dividing
R9000	T30040	T30041	amod	equal,parts
R9001	T30041	T30039	pobj	parts,into
R9002	T30042	T30032	cc	and,dividing
R9003	T30043	T30032	conj	extending,dividing
R9004	T30044	T30045	det	a,line
R9005	T30045	T30043	dobj	line,extending
R9006	T30046	T30043	prep	to,extending
R9007	T30047	T30048	det	the,edge
R9008	T30048	T30046	pobj	edge,to
R9009	T30049	T30048	amod	vitreal,edge
R9010	T30050	T30051	punct	[,2
R9011	T30051	T30043	parataxis	2,extending
R9012	T30052	T30051	punct	],2
R9013	T30053	T30026	punct	.,separated
R9014	T30055	T30056	nsubj	Bin,contains
R9015	T30056	T30058	ccomp	contains,is
R9016	T30057	T30055	nummod	1,Bin
R9017	T30059	T30060	amod	only,cells
R9018	T30060	T30056	dobj	cells,contains
R9019	T30061	T30062	dep	that,expressed
R9020	T30062	T30060	relcl	expressed,cells
R9021	T30063	T30062	dobj	Cre,expressed
R9022	T30064	T30062	prep	as,expressed
R9023	T30065	T30064	pobj	progenitors,as
R9024	T30066	T30058	punct	;,is
R9025	T30067	T30058	nsubj	bin,is
R9026	T30068	T30067	nummod	3,bin
R9027	T30069	T30058	prep	at,is
R9028	T30070	T30071	amod	central,retina
R9029	T30071	T30069	pobj	retina,at
R9030	T30072	T30058	cc	and,is
R9031	T30073	T30058	conj	contains,is
R9032	T30074	T30073	dobj	cells,contains
R9033	T30075	T30074	acl	derived,cells
R9034	T30076	T30075	prep	from,derived
R9035	T30077	T30076	pobj	progenitors,from
R9036	T30078	T30079	dep	that,express
R9037	T30079	T30077	relcl	express,progenitors
R9038	T30080	T30079	aux	did,express
R9039	T30081	T30079	neg	not,express
R9040	T30082	T30079	dobj	Cre,express
R9041	T30083	T30058	punct	.,is
R9042	T30085	T30086	prep	For,used
R9043	T30087	T30088	compound	cell,counts
R9044	T30088	T30085	pobj	counts,For
R9045	T30089	T30088	cc	or,counts
R9046	T30090	T30091	compound	thickness,measurement
R9047	T30091	T30088	conj	measurement,counts
R9048	T30092	T30086	nsubj	we,used
R9049	T30093	T30094	det	a,region
R9050	T30094	T30086	dobj	region,used
R9051	T30095	T30096	quantmod	0,100
R9052	T30096	T30098	nummod	100,μm
R9053	T30097	T30096	punct	–,100
R9054	T30098	T30099	npadvmod	μm,peripheral
R9055	T30099	T30094	amod	peripheral,region
R9056	T30100	T30099	prep	to,peripheral
R9057	T30101	T30102	det	the,boundary
R9058	T30102	T30100	pobj	boundary,to
R9059	T30103	T30102	acl	separating,boundary
R9060	T30104	T30105	nmod	bins,1
R9061	T30105	T30103	dobj	1,separating
R9062	T30106	T30105	cc	and,1
R9063	T30107	T30105	conj	2,1
R9064	T30108	T30086	punct	.,used
R9065	T30110	T30111	nsubjpass	Measurements,performed
R9066	T30112	T30111	auxpass	were,performed
R9067	T30113	T30111	prep	on,performed
R9068	T30114	T30115	det	an,microscope
R9069	T30115	T30113	pobj	microscope,on
R9070	T30116	T30115	nmod	Axioplan,microscope
R9071	T30117	T30116	punct	-,Axioplan
R9072	T30118	T30116	nummod	2,Axioplan
R9073	T30119	T30111	advcl	using,performed
R9074	T30120	T30121	compound	Axiovison,software
R9075	T30121	T30119	dobj	software,using
R9076	T30122	T30111	punct	.,performed
R9077	T30124	T30125	nsubjpass	Quantification,performed
R9078	T30126	T30124	prep	of,Quantification
R9079	T30127	T30128	nmod	S,phase
R9080	T30128	T30130	nmod	phase,cells
R9081	T30129	T30128	punct	-,phase
R9082	T30130	T30126	pobj	cells,of
R9083	T30131	T30128	punct	", ",phase
R9084	T30132	T30133	compound	M,phase
R9085	T30133	T30128	conj	phase,phase
R9086	T30134	T30133	punct	-,phase
R9087	T30135	T30133	punct	", ",phase
R9088	T30136	T30133	cc	and,phase
R9089	T30137	T30133	conj	apoptotic,phase
R9090	T30138	T30125	auxpass	was,performed
R9091	T30139	T30125	prep	on,performed
R9092	T30140	T30141	amod	horizontal,sections
R9093	T30141	T30139	pobj	sections,on
R9094	T30142	T30143	dep	that,included
R9095	T30143	T30141	relcl	included,sections
R9096	T30144	T30145	det	the,nerve
R9097	T30145	T30143	dobj	nerve,included
R9098	T30146	T30145	amod	optic,nerve
R9099	T30147	T30125	punct	.,performed
R9100	T30149	T30150	nsubjpass	Quantification,performed
R9101	T30151	T30149	prep	of,Quantification
R9102	T30152	T30153	amod	differentiated,types
R9103	T30153	T30151	pobj	types,of
R9104	T30154	T30153	compound	cell,types
R9105	T30155	T30150	auxpass	was,performed
R9106	T30156	T30150	advcl	using,performed
R9107	T30157	T30158	amod	horizontal,sections
R9108	T30158	T30156	dobj	sections,using
R9109	T30159	T30158	prep	at,sections
R9110	T30160	T30161	amod	equal,distances
R9111	T30161	T30159	pobj	distances,at
R9112	T30162	T30161	prep	from,distances
R9113	T30163	T30164	det	the,nerve
R9114	T30164	T30162	pobj	nerve,from
R9115	T30165	T30164	amod	optic,nerve
R9116	T30166	T30150	punct	.,performed
R9117	T30168	T30169	det	A,minimum
R9118	T30169	T30170	nsubjpass	minimum,counted
R9119	T30171	T30169	prep	of,minimum
R9120	T30172	T30173	nummod	three,sections
R9121	T30173	T30171	pobj	sections,of
R9122	T30174	T30173	prep	per,sections
R9123	T30175	T30174	pobj	eye,per
R9124	T30176	T30173	cc	and,sections
R9125	T30177	T30178	nummod	three,eyes
R9126	T30178	T30173	conj	eyes,sections
R9127	T30179	T30178	prep	from,eyes
R9128	T30180	T30181	amod	different,litters
R9129	T30181	T30179	pobj	litters,from
R9130	T30182	T30170	auxpass	were,counted
R9131	T30183	T30170	punct	.,counted
R9134	T30759	T30760	compound	RNA,extraction
R9135	T30761	T30760	punct	", ",extraction
R9136	T30762	T30763	amod	reverse,transcription
R9137	T30763	T30760	conj	transcription,extraction
R9138	T30764	T30763	punct	", ",transcription
R9139	T30765	T30763	cc	and,transcription
R9140	T30766	T30763	conj	PCR,transcription
R9141	T30767	T30766	punct	.,PCR
R9142	T30769	T30770	amod	Total,RNA
R9143	T30770	T30771	nsubjpass	RNA,isolated
R9144	T30772	T30771	auxpass	was,isolated
R9145	T30773	T30771	prep	from,isolated
R9146	T30774	T30775	amod	dissected,retina
R9147	T30775	T30773	pobj	retina,from
R9148	T30776	T30775	amod	peripheral,retina
R9149	T30777	T30771	advcl	using,isolated
R9150	T30778	T30779	compound	TRIzol,reagent
R9151	T30779	T30777	dobj	reagent,using
R9152	T30780	T30781	punct	(,Invitrogen
R9153	T30781	T30779	parataxis	Invitrogen,reagent
R9154	T30782	T30781	punct	", ",Invitrogen
R9155	T30783	T30781	npadvmod	http://www.invitrogen.com,Invitrogen
R9156	T30784	T30781	punct	),Invitrogen
R9157	T30785	T30779	acl	followed,reagent
R9158	T30786	T30785	agent	by,followed
R9159	T30787	T30786	pobj	digestion,by
R9160	T30788	T30787	prep	with,digestion
R9161	T30789	T30790	npadvmod	RNase,free
R9162	T30790	T30792	amod	free,DNase
R9163	T30791	T30790	punct	-,free
R9164	T30792	T30788	pobj	DNase,with
R9165	T30793	T30792	punct	(,DNase
R9166	T30794	T30792	appos	DNA,DNase
R9178	T30806	T30771	punct	.,isolated
R9179	T30808	T30809	amod	First,strand
R9180	T30809	T30811	compound	strand,cDNA
R9181	T30810	T30809	punct	-,strand
R9182	T30811	T30812	nsubjpass	cDNA,synthesized
R9183	T30813	T30812	auxpass	was,synthesized
R9184	T30814	T30812	prep	from,synthesized
R9185	T30815	T30816	quantmod	0.2,0.5
R9186	T30816	T30818	nummod	0.5,μg
R9187	T30817	T30816	punct	–,0.5
R9188	T30818	T30814	pobj	μg,from
R9189	T30819	T30818	prep	of,μg
R9190	T30820	T30821	amod	total,RNA
R9191	T30821	T30819	pobj	RNA,of
R9192	T30822	T30812	advcl	using,synthesized
R9193	T30823	T30824	det	the,system
R9194	T30824	T30822	dobj	system,using
R9195	T30825	T30824	nmod	SuperScript,system
R9196	T30826	T30825	nummod	II,SuperScript
R9197	T30827	T30828	amod	first,strand
R9198	T30828	T30830	compound	strand,synthesis
R9199	T30829	T30828	punct	-,strand
R9200	T30830	T30824	compound	synthesis,system
R9201	T30831	T30832	punct	(,Invitrogen
R9202	T30832	T30822	parataxis	Invitrogen,using
R9203	T30833	T30832	punct	),Invitrogen
R9204	T30834	T30812	punct	.,synthesized
R9205	T30836	T30837	compound	PCR,primers
R9206	T30837	T30838	nsubjpass	primers,listed
R9207	T30839	T30838	auxpass	are,listed
R9208	T30840	T30838	prep	in,listed
R9209	T30841	T30842	compound	Table,S2
R9210	T30842	T30840	pobj	S2,in
R9211	T30843	T30838	punct	.,listed
R9212	T30845	T30846	amod	Real,time
R9213	T30846	T30848	nmod	time,PCR
R9214	T30847	T30846	punct	-,time
R9215	T30848	T30850	nsubjpass	PCR,performed
R9216	T30849	T30848	amod	quantitative,PCR
R9217	T30851	T30850	auxpass	was,performed
R9218	T30852	T30850	advcl	using,performed
R9219	T30853	T30854	det	an,7900HT
R9220	T30854	T30852	dobj	7900HT,using
R9221	T30855	T30856	nmod	Applied,Biosystems
R9222	T30856	T30854	nmod	Biosystems,7900HT
R9223	T30857	T30856	punct	(,Biosystems
R9224	T30858	T30856	appos	http://appliedbiosystems.com,Biosystems
R9225	T30859	T30854	punct	),7900HT
R9226	T30860	T30854	compound	PRISM,7900HT
R9227	T30861	T30850	punct	.,performed
R9228	T30863	T30864	nsubjpass	Tests,run
R9229	T30865	T30864	auxpass	were,run
R9230	T30866	T30864	prep	in,run
R9231	T30867	T30866	pobj	duplicate,in
R9232	T30868	T30864	prep	on,run
R9233	T30869	T30870	nummod	three,samples
R9234	T30870	T30868	pobj	samples,on
R9235	T30871	T30870	amod	separate,samples
R9236	T30872	T30870	amod	biological,samples
R9237	T30873	T30864	prep	with,run
R9238	T30874	T30875	nmod	SYBR,Mix
R9239	T30875	T30873	pobj	Mix,with
R9240	T30876	T30875	amod	Green,Mix
R9241	T30877	T30875	compound	PCR,Mix
R9242	T30878	T30875	compound	Master,Mix
R9243	T30879	T30880	punct	(,Biosystems
R9244	T30880	T30875	parataxis	Biosystems,Mix
R9245	T30881	T30880	compound	Applied,Biosystems
R9246	T30882	T30880	punct	),Biosystems
R9247	T30883	T30884	advmod	exactly,described
R9248	T30884	T30864	advcl	described,run
R9249	T30885	T30884	mark	as,described
R9250	T30886	T30884	nsubj	we,described
R9251	T30887	T30884	advmod	previously,described
R9252	T30888	T30889	punct	[,71
R9253	T30889	T30884	parataxis	71,described
R9254	T30890	T30889	punct	],71
R9255	T30891	T30864	punct	.,run
R9256	T30893	T30894	advmod	Briefly,prepared
R9257	T30895	T30894	punct	", ",prepared
R9258	T30896	T30897	compound	master,stocks
R9259	T30897	T30894	nsubjpass	stocks,prepared
R9260	T30898	T30894	auxpass	were,prepared
R9261	T30899	T30900	amod	such,contained
R9262	T30900	T30894	advcl	contained,prepared
R9263	T30901	T30900	mark	that,contained
R9264	T30902	T30903	det	each,reaction
R9265	T30903	T30900	nsubj	reaction,contained
R9266	T30904	T30905	nummod	10,μl
R9267	T30905	T30903	compound	μl,reaction
R9268	T30906	T30905	punct	-,μl
R9269	T30907	T30908	nummod	5,μl
R9270	T30908	T30900	dobj	μl,contained
R9271	T30909	T30908	prep	of,μl
R9272	T30910	T30911	nmod	SYBR,Mix
R9273	T30911	T30909	pobj	Mix,of
R9274	T30912	T30911	amod	Green,Mix
R9275	T30913	T30911	compound	PCR,Mix
R9276	T30914	T30911	compound	Master,Mix
R9277	T30915	T30908	punct	", ",μl
R9278	T30916	T30917	nummod	0.1,μl
R9279	T30917	T30908	conj	μl,μl
R9280	T30918	T30917	prep	of,μl
R9281	T30919	T30920	det	each,primer
R9282	T30920	T30918	pobj	primer,of
R9283	T30921	T30920	nmod	forward,primer
R9284	T30922	T30921	cc	and,forward
R9285	T30923	T30921	conj	reverse,forward
R9286	T30924	T30925	punct	(,μM
R9287	T30925	T30920	parataxis	μM,primer
R9288	T30926	T30925	nmod	stock,μM
R9289	T30927	T30925	nummod	50,μM
R9290	T30928	T30925	punct	),μM
R9291	T30929	T30917	punct	", ",μl
R9292	T30930	T30931	nummod	0.8,μl
R9293	T30931	T30917	conj	μl,μl
R9294	T30932	T30931	prep	of,μl
R9295	T30933	T30934	amod	blue,H2O
R9296	T30934	T30932	pobj	H2O,of
R9297	T30935	T30936	punct	(,McCormick
R9298	T30936	T30934	parataxis	McCormick,H2O
R9299	T30937	T30938	nummod	0.73,%
R9300	T30938	T30939	compound	%,Colour
R9301	T30939	T30936	dep	Colour,McCormick
R9302	T30940	T30939	compound	Blue,Colour
R9303	T30941	T30939	compound	Food,Colour
R9304	T30942	T30936	punct	;,McCormick
R9305	T30943	T30936	punct	", ",McCormick
R9306	T30944	T30936	npadvmod	http://www.mccormick.com,McCormick
R9307	T30945	T30936	punct	),McCormick
R9308	T30946	T30931	punct	", ",μl
R9309	T30947	T30948	nummod	2,μl
R9310	T30948	T30931	conj	μl,μl
R9311	T30949	T30948	prep	of,μl
R9312	T30950	T30951	amod	diluted,template
R9313	T30951	T30949	pobj	template,of
R9314	T30952	T30951	compound	cDNA,template
R9315	T30953	T30948	punct	", ",μl
R9316	T30954	T30948	cc	and,μl
R9317	T30955	T30956	nummod	2,μl
R9318	T30956	T30948	conj	μl,μl
R9319	T30957	T30956	prep	of,μl
R9320	T30958	T30959	amod	yellow,H2O
R9321	T30959	T30957	pobj	H2O,of
R9322	T30960	T30961	punct	(,Colour
R9323	T30961	T30959	parataxis	Colour,H2O
R9324	T30962	T30963	nummod	0.73,%
R9325	T30963	T30961	nmod	%,Colour
R9326	T30964	T30961	amod	Yellow,Colour
R9327	T30965	T30961	compound	Food,Colour
R9328	T30966	T30961	punct	),Colour
R9329	T30967	T30894	punct	.,prepared
R9330	T30969	T30970	nsubj	PCR,consisted
R9331	T30971	T30970	prep	of,consisted
R9332	T30972	T30973	nummod	40,cycles
R9333	T30973	T30971	pobj	cycles,of
R9334	T30974	T30973	prep	of,cycles
R9335	T30975	T30974	pobj	denaturation,of
R9336	T30976	T30973	prep	at,cycles
R9337	T30977	T30978	nummod	95,°C
R9338	T30978	T30976	pobj	°C,at
R9339	T30979	T30973	prep	for,cycles
R9340	T30980	T30981	nummod	15,s
R9341	T30981	T30979	pobj	s,for
R9342	T30982	T30973	cc	and,cycles
R9343	T30983	T30973	conj	annealing,cycles
R9344	T30984	T30983	cc	and,annealing
R9345	T30985	T30983	conj	extension,annealing
R9346	T30986	T30983	prep	at,annealing
R9347	T30987	T30988	nummod	55,°C
R9348	T30988	T30986	pobj	°C,at
R9349	T30989	T30983	prep	for,annealing
R9350	T30990	T30991	nummod	30,s
R9351	T30991	T30989	pobj	s,for
R9352	T30992	T30970	punct	.,consisted
R9353	T30994	T30995	det	An,cycle
R9354	T30995	T30997	nsubj	cycle,generated
R9355	T30996	T30995	amod	additional,cycle
R9356	T30998	T30999	punct	(,°C
R9357	T30999	T30995	parataxis	°C,cycle
R9358	T31000	T31001	nummod	95,°C
R9359	T31001	T30999	dep	°C,°C
R9360	T31002	T30999	punct	", ",°C
R9361	T31003	T31004	nummod	15,s
R9362	T31004	T30999	dep	s,°C
R9363	T31005	T30999	punct	", ",°C
R9364	T31006	T30999	nummod	60,°C
R9365	T31007	T30999	punct	),°C
R9366	T31008	T31009	det	a,curve
R9367	T31009	T30997	dobj	curve,generated
R9368	T31010	T31009	compound	dissociation,curve
R9369	T31011	T31012	aux	to,confirm
R9370	T31012	T30997	advcl	confirm,generated
R9371	T31013	T31014	det	a,product
R9372	T31014	T31012	dobj	product,confirm
R9373	T31015	T31014	amod	single,product
R9374	T31016	T30997	punct	.,generated
R9375	T31018	T31019	det	The,quantity
R9376	T31019	T31021	nsubjpass	quantity,determined
R9377	T31020	T31019	compound	cycle,quantity
R9378	T31022	T31019	acl	required,quantity
R9379	T31023	T31024	aux	to,reach
R9380	T31024	T31022	xcomp	reach,required
R9381	T31025	T31026	det	a,threshold
R9382	T31026	T31024	dobj	threshold,reach
R9383	T31027	T31024	prep	in,reach
R9384	T31028	T31029	det	the,range
R9385	T31029	T31027	pobj	range,in
R9386	T31030	T31029	amod	linear,range
R9387	T31031	T31021	auxpass	was,determined
R9388	T31032	T31021	cc	and,determined
R9389	T31033	T31021	conj	compared,determined
R9390	T31034	T31033	prep	to,compared
R9391	T31035	T31036	det	a,curve
R9392	T31036	T31034	pobj	curve,to
R9393	T31037	T31036	amod	standard,curve
R9394	T31038	T31036	prep	for,curve
R9395	T31039	T31040	det	each,set
R9396	T31040	T31038	pobj	set,for
R9397	T31041	T31040	compound	primer,set
R9398	T31042	T31040	acl	generated,set
R9399	T31043	T31042	agent	by,generated
R9400	T31044	T31045	nummod	five,dilutions
R9401	T31045	T31043	pobj	dilutions,by
R9402	T31046	T31045	nummod	3,dilutions
R9403	T31047	T31046	punct	-,3
R9404	T31048	T31046	amod	fold,3
R9405	T31049	T31045	prep	of,dilutions
R9406	T31050	T31051	amod	genomic,samples
R9407	T31051	T31049	pobj	samples,of
R9408	T31052	T31051	nmod	DNA,samples
R9409	T31053	T31052	cc	or,DNA
R9410	T31054	T31052	conj	cDNA,DNA
R9411	T31055	T31051	prep	of,samples
R9412	T31056	T31057	amod	known,concentration
R9413	T31057	T31055	pobj	concentration,of
R9414	T31058	T31021	punct	.,determined
R9415	T31060	T31061	nsubj	Values,obtained
R9416	T31062	T31063	mark	for,normalized
R9417	T31063	T31061	advcl	normalized,obtained
R9418	T31064	T31065	compound	test,RNAs
R9419	T31065	T31063	nsubjpass	RNAs,normalized
R9420	T31066	T31063	auxpass	were,normalized
R9421	T31067	T31063	prep	to,normalized
R9422	T31068	T31069	compound	Hprt1,mRNA
R9423	T31069	T31070	compound	mRNA,levels
R9424	T31070	T31067	pobj	levels,to
R9425	T31071	T31061	punct	.,obtained
R9426	T31588	T31589	compound	Western,blots
R9427	T31590	T31589	punct	.,blots
R9428	T31592	T31593	compound	Mouse,retinas
R9429	T31593	T31594	nsubjpass	retinas,homogenized
R9430	T31595	T31594	auxpass	were,homogenized
R9431	T31596	T31594	prep	by,homogenized
R9432	T31597	T31596	pcomp	passing,by
R9433	T31598	T31597	dobj	them,passing
R9434	T31599	T31597	prep	through,passing
R9435	T31600	T31601	det	a,needle
R9436	T31601	T31599	pobj	needle,through
R9437	T31602	T31603	nummod	30,gauge
R9438	T31603	T31601	nmod	gauge,needle
R9439	T31604	T31603	punct	-,gauge
R9440	T31605	T31601	nmod	BD,needle
R9441	T31606	T31605	nummod	9,BD
R9442	T31607	T31605	appos	http://www.bd.com,BD
R9443	T31608	T31601	punct	),needle
R9444	T31609	T31610	quantmod	5,10
R9445	T31610	T31612	nummod	10,times
R9446	T31611	T31610	punct	–,10
R9447	T31612	T31594	npadvmod	times,homogenized
R9448	T31613	T31594	prep	in,homogenized
R9449	T31614	T31615	nummod	1,solution
R9450	T31615	T31613	pobj	solution,in
R9451	T31616	T31614	punct	×,1
R9452	T31617	T31615	compound	PBS,solution
R9453	T31618	T31594	punct	.,homogenized
R9454	T31620	T31621	amod	Nuclear,proteins
R9455	T31621	T31624	nsubjpass	proteins,extracted
R9456	T31622	T31620	cc	and,Nuclear
R9457	T31623	T31620	conj	cytoplasmic,Nuclear
R9458	T31625	T31624	auxpass	were,extracted
R9459	T31626	T31624	advcl	using,extracted
R9460	T31627	T31628	det	the,Kit
R9461	T31628	T31626	dobj	Kit,using
R9462	T31629	T31630	nmod	NE,PER
R9463	T31630	T31628	nmod	PER,Kit
R9464	T31631	T31630	punct	-,PER
R9465	T31632	T31628	amod	Nuclear,Kit
R9466	T31633	T31632	cc	and,Nuclear
R9467	T31634	T31632	conj	Cytoplasmic,Nuclear
R9468	T31635	T31628	compound	Extraction,Kit
R9469	T31636	T31628	punct	(,Kit
R9470	T31637	T31628	appos	Product,Kit
R9471	T31638	T31637	punct	#,Product
R9472	T31639	T31637	nummod	78833,Product
R9473	T31640	T31641	punct	", ",Biotechnology
R9474	T31641	T31628	parataxis	Biotechnology,Kit
R9475	T31642	T31641	compound	Pierce,Biotechnology
R9476	T31643	T31641	punct	", ",Biotechnology
R9477	T31644	T31641	npadvmod	http://www.piercenet.com,Biotechnology
R9478	T31645	T31641	punct	),Biotechnology
R9479	T31646	T31624	punct	.,extracted
R9480	T31648	T31649	nsubjpass	Proteins,separated
R9481	T31650	T31649	auxpass	were,separated
R9482	T31651	T31649	prep	by,separated
R9483	T31652	T31653	nummod	10,%
R9484	T31653	T31654	compound	%,PAGE
R9485	T31654	T31651	pobj	PAGE,by
R9486	T31655	T31654	compound	SDS,PAGE
R9487	T31656	T31654	punct	-,PAGE
R9488	T31657	T31649	cc	and,separated
R9489	T31658	T31649	conj	transferred,separated
R9490	T31659	T31658	prep	to,transferred
R9491	T31660	T31659	pobj	nitrocellulose,to
R9492	T31661	T31649	punct	.,separated
R9493	T31663	T31664	prep	After,incubated
R9494	T31665	T31663	pcomp	blocking,After
R9495	T31666	T31665	advmod	overnight,blocking
R9496	T31667	T31665	prep	at,blocking
R9497	T31668	T31669	nummod	4,°C
R9498	T31669	T31667	pobj	°C,at
R9499	T31670	T31665	prep	in,blocking
R9500	T31671	T31672	nummod	5,%
R9501	T31672	T31673	compound	%,milk
R9502	T31673	T31670	pobj	milk,in
R9503	T31674	T31673	compound	skim,milk
R9504	T31675	T31664	punct	", ",incubated
R9505	T31676	T31664	nsubjpass	membranes,incubated
R9506	T31677	T31664	auxpass	were,incubated
R9507	T31678	T31664	prep	in,incubated
R9508	T31679	T31680	det	the,antibody
R9509	T31680	T31678	pobj	antibody,in
R9510	T31681	T31680	amod	primary,antibody
R9511	T31682	T31664	prep	for,incubated
R9512	T31683	T31684	nummod	2,h
R9513	T31684	T31682	pobj	h,for
R9514	T31685	T31664	prep	at,incubated
R9515	T31686	T31687	compound	room,temperature
R9516	T31687	T31685	pobj	temperature,at
R9517	T31688	T31664	punct	.,incubated
R9518	T31690	T31691	prep	After,incubated
R9519	T31692	T31693	nummod	three,washes
R9520	T31693	T31690	pobj	washes,After
R9521	T31694	T31695	nummod	10,min
R9522	T31695	T31693	compound	min,washes
R9523	T31696	T31695	punct	-,min
R9524	T31697	T31693	prep	in,washes
R9525	T31698	T31697	pobj	TPBS,in
R9526	T31699	T31698	punct	(,TPBS
R9527	T31700	T31701	nummod	100,mM
R9528	T31701	T31702	compound	mM,Na2HPO4
R9529	T31702	T31698	appos	Na2HPO4,TPBS
R9530	T31703	T31702	punct	", ",Na2HPO4
R9531	T31704	T31705	nummod	100,mM
R9532	T31705	T31706	compound	mM,NaH2PO4
R9533	T31706	T31702	appos	NaH2PO4,Na2HPO4
R9534	T31707	T31702	punct	", ",Na2HPO4
R9535	T31708	T31709	nummod	0.5,N
R9536	T31709	T31710	compound	N,NaCl
R9537	T31710	T31702	appos	NaCl,Na2HPO4
R9538	T31711	T31702	punct	", ",Na2HPO4
R9539	T31712	T31713	nummod	0.1,%
R9540	T31713	T31714	compound	%,Tween
R9541	T31714	T31702	appos	Tween,Na2HPO4
R9542	T31715	T31714	punct	-,Tween
R9543	T31716	T31714	nummod	20,Tween
R9544	T31717	T31691	punct	),incubated
R9545	T31718	T31691	punct	", ",incubated
R9546	T31719	T31691	nsubjpass	membranes,incubated
R9547	T31720	T31691	auxpass	were,incubated
R9548	T31721	T31691	prep	for,incubated
R9549	T31722	T31723	nummod	30,min
R9550	T31723	T31721	pobj	min,for
R9551	T31724	T31691	prep	at,incubated
R9552	T31725	T31726	compound	room,temperature
R9553	T31726	T31724	pobj	temperature,at
R9554	T31727	T31691	prep	in,incubated
R9555	T31728	T31729	det	the,antibody
R9556	T31729	T31727	pobj	antibody,in
R9557	T31730	T31729	amod	secondary,antibody
R9558	T31731	T31732	compound	horseradish,peroxidase
R9559	T31732	T31733	npadvmod	peroxidase,conjugated
R9560	T31733	T31729	amod	conjugated,antibody
R9561	T31734	T31733	punct	-,conjugated
R9562	T31735	T31736	punct	(,Laboratories
R9563	T31736	T31729	parataxis	Laboratories,antibody
R9564	T31737	T31736	compound	Jackson,Laboratories
R9565	T31738	T31736	compound	ImmunoResearch,Laboratories
R9566	T31739	T31736	punct	", ",Laboratories
R9567	T31740	T31736	npadvmod	http://www.jacksonimmuno.com,Laboratories
R9568	T31741	T31736	punct	),Laboratories
R9569	T31742	T31691	punct	.,incubated
R9570	T31744	T31745	nsubjpass	Blots,developed
R9571	T31746	T31745	auxpass	were,developed
R9572	T31747	T31745	advcl	using,developed
R9573	T31748	T31749	det	the,system
R9574	T31749	T31747	dobj	system,using
R9575	T31750	T31751	nmod	ECL,Plus
R9576	T31751	T31749	nmod	Plus,system
R9577	T31752	T31751	punct	-,Plus
R9578	T31753	T31749	amod	chemiluminescent,system
R9579	T31754	T31749	compound	detection,system
R9580	T31755	T31756	punct	(,Biotech
R9581	T31756	T31749	parataxis	Biotech,system
R9582	T31757	T31756	compound	Amersham,Biotech
R9583	T31758	T31756	compound	Pharmacia,Biotech
R9584	T31759	T31756	punct	", ",Biotech
R9585	T31760	T31756	npadvmod	http://www.pharmacia.ca,Biotech
R9586	T31761	T31756	punct	),Biotech
R9587	T31762	T31747	punct	", ",using
R9588	T31763	T31747	prep	according,using
R9589	T31764	T31763	prep	to,according
R9590	T31765	T31766	det	the,manufacturer
R9591	T31766	T31767	poss	manufacturer,instructions
R9592	T31767	T31764	pobj	instructions,to
R9593	T31768	T31766	case	's,manufacturer
R9594	T31769	T31745	punct	.,developed
R9595	T31771	T31772	det	The,antibodies
R9596	T31772	T31775	nsubjpass	antibodies,used
R9597	T31773	T31772	amod	following,antibodies
R9598	T31774	T31772	amod	primary,antibodies
R9599	T31776	T31775	auxpass	were,used
R9600	T31777	T31775	punct	: ,used
R9601	T31778	T31775	dobj	E2f,used
R9602	T31779	T31778	punct	-,E2f
R9603	T31780	T31778	nummod	1,E2f
R9604	T31781	T31778	punct	(,E2f
R9605	T31782	T31778	appos	SC,E2f
R9606	T31783	T31782	punct	-,SC
R9607	T31784	T31782	nummod	193,SC
R9608	T31785	T31778	punct	),E2f
R9609	T31786	T31778	punct	", ",E2f
R9610	T31787	T31778	conj	E2f,E2f
R9611	T31788	T31787	punct	-,E2f
R9612	T31789	T31787	nummod	3,E2f
R9613	T31790	T31787	punct	(,E2f
R9614	T31791	T31787	appos	SC,E2f
R9615	T31792	T31791	punct	-,SC
R9616	T31793	T31791	nummod	878,SC
R9617	T31794	T31787	punct	),E2f
R9618	T31795	T31787	punct	", ",E2f
R9619	T31796	T31787	conj	Cdkn1a,E2f
R9620	T31797	T31796	punct	(,Cdkn1a
R9621	T31798	T31796	appos	p21,Cdkn1a
R9622	T31799	T31796	punct	", ",Cdkn1a
R9623	T31800	T31796	appos	SC,Cdkn1a
R9624	T31801	T31800	punct	-,SC
R9625	T31802	T31800	nummod	471,SC
R9626	T31803	T31796	punct	),Cdkn1a
R9627	T31804	T31796	punct	", ",Cdkn1a
R9628	T31805	T31796	conj	Cdkn1b,Cdkn1a
R9629	T31806	T31805	punct	(,Cdkn1b
R9630	T31807	T31805	appos	p27,Cdkn1b
R9631	T31808	T31805	punct	", ",Cdkn1b
R9632	T31809	T31805	appos	SC,Cdkn1b
R9633	T31810	T31809	punct	-,SC
R9634	T31811	T31809	nummod	528,SC
R9635	T31812	T31805	punct	),Cdkn1b
R9636	T31813	T31805	punct	", ",Cdkn1b
R9637	T31814	T31805	conj	Pou4f2,Cdkn1b
R9638	T31815	T31814	punct	(,Pou4f2
R9639	T31816	T31814	appos	Brn3b,Pou4f2
R9640	T31817	T31814	punct	", ",Pou4f2
R9641	T31818	T31814	appos	SC,Pou4f2
R9642	T31819	T31818	punct	-,SC
R9643	T31820	T31818	nummod	6062,SC
R9644	T31821	T31814	punct	),Pou4f2
R9645	T31822	T31814	punct	", ",Pou4f2
R9646	T31823	T31814	cc	and,Pou4f2
R9647	T31824	T31814	conj	Tfdp1,Pou4f2
R9648	T31825	T31824	punct	(,Tfdp1
R9649	T31826	T31824	appos	Dp1,Tfdp1
R9650	T31827	T31824	punct	", ",Tfdp1
R9651	T31828	T31824	appos	SC,Tfdp1
R9652	T31829	T31828	punct	-,SC
R9653	T31830	T31828	nummod	610,SC
R9654	T31831	T31778	punct	),E2f
R9655	T31832	T31778	prep	from,E2f
R9656	T31833	T31834	compound	Santa,Biotechnology
R9657	T31834	T31832	pobj	Biotechnology,from
R9658	T31835	T31834	compound	Cruz,Biotechnology
R9659	T31836	T31834	punct	(,Biotechnology
R9660	T31837	T31834	npadvmod	http://www.scbt.com,Biotechnology
R9661	T31838	T31778	punct	),E2f
R9662	T31839	T31778	punct	", ",E2f
R9663	T31840	T31778	conj	pRB,E2f
R9664	T31841	T31840	punct	(,pRB
R9665	T31842	T31840	appos	554136,pRB
R9666	T31843	T31840	punct	),pRB
R9667	T31844	T31840	prep	from,pRB
R9668	T31845	T31846	compound	BD,Pharmingen
R9669	T31846	T31844	pobj	Pharmingen,from
R9670	T31847	T31846	compound	Science,Pharmingen
R9671	T31848	T31846	punct	-,Pharmingen
R9672	T31849	T31846	punct	(,Pharmingen
R9673	T31850	T31846	npadvmod	http://www.bdbiosciences.com,Pharmingen
R9674	T31851	T31840	punct	),pRB
R9675	T31852	T31840	punct	", ",pRB
R9676	T31853	T31840	cc	and,pRB
R9677	T31854	T31840	conj	Slc18a3,pRB
R9678	T31855	T31854	punct	(,Slc18a3
R9679	T31856	T31854	appos	VAChT,Slc18a3
R9680	T31857	T31854	punct	", ",Slc18a3
R9681	T31858	T31854	appos	G448A,Slc18a3
R9682	T31859	T31854	punct	),Slc18a3
R9683	T31860	T31854	prep	from,Slc18a3
R9684	T31861	T31860	pobj	Promega,from
R9685	T31862	T31861	punct	(,Promega
R9686	T31863	T31861	npadvmod	http://www.promega.com,Promega
R9687	T31864	T31775	punct	),used
R9688	T31865	T31775	punct	.,used
R9689	T32267	T32266	punct	.,Electroretinography
R9690	T32269	T32270	nsubjpass	ERGs,recorded
R9691	T32271	T32270	auxpass	were,recorded
R9692	T32272	T32270	prep	from,recorded
R9693	T32273	T32274	npadvmod	dark,adapted
R9694	T32274	T32276	amod	adapted,mice
R9695	T32275	T32274	punct	-,adapted
R9696	T32276	T32272	pobj	mice,from
R9697	T32277	T32278	mark	as,described
R9698	T32278	T32270	advcl	described,recorded
R9699	T32279	T32280	punct	[,72
R9700	T32280	T32278	parataxis	72,described
R9701	T32281	T32280	punct	],72
R9702	T32282	T32270	punct	.,recorded
R9703	T32284	T32285	advmod	Briefly,adapted
R9704	T32286	T32285	punct	", ",adapted
R9705	T32287	T32285	nsubjpass	mice,adapted
R9706	T32288	T32285	auxpass	were,adapted
R9707	T32289	T32285	dep	dark,adapted
R9708	T32290	T32285	punct	-,adapted
R9709	T32291	T32285	advmod	overnight,adapted
R9710	T32292	T32285	cc	and,adapted
R9711	T32293	T32285	conj	anaesthetized,adapted
R9712	T32294	T32293	prep	by,anaesthetized
R9713	T32295	T32296	amod	subcutaneous,injection
R9714	T32296	T32294	pobj	injection,by
R9715	T32297	T32296	prep	of,injection
R9716	T32298	T32297	pobj	ketamine,of
R9717	T32299	T32300	punct	(,mg
R9718	T32300	T32298	parataxis	mg,ketamine
R9719	T32301	T32300	nummod	66.7,mg
R9720	T32302	T32303	punct	/,weight
R9721	T32303	T32300	prep	weight,mg
R9722	T32304	T32303	compound	kg,weight
R9723	T32305	T32303	compound	body,weight
R9724	T32306	T32300	punct	),mg
R9725	T32307	T32298	cc	and,ketamine
R9726	T32308	T32298	conj	xylazine,ketamine
R9727	T32309	T32310	punct	(,mg
R9728	T32310	T32308	parataxis	mg,xylazine
R9729	T32311	T32310	nummod	11.7,mg
R9730	T32312	T32313	punct	/,weight
R9731	T32313	T32310	prep	weight,mg
R9732	T32314	T32313	compound	kg,weight
R9733	T32315	T32313	compound	body,weight
R9734	T32316	T32310	punct	),mg
R9735	T32317	T32285	punct	.,adapted
R9736	T32319	T32320	det	The,pupils
R9737	T32320	T32321	nsubjpass	pupils,dilated
R9738	T32322	T32321	auxpass	were,dilated
R9739	T32323	T32321	cc	and,dilated
R9740	T32324	T32325	amod	single,flash
R9741	T32325	T32327	compound	flash,recordings
R9742	T32326	T32325	punct	-,flash
R9743	T32327	T32329	nsubjpass	recordings,obtained
R9744	T32328	T32327	compound	ERG,recordings
R9745	T32329	T32321	conj	obtained,dilated
R9746	T32330	T32329	auxpass	were,obtained
R9747	T32331	T32329	prep	under,obtained
R9748	T32332	T32333	npadvmod	dark,adapted
R9749	T32333	T32335	amod	adapted,conditions
R9750	T32334	T32333	punct	-,adapted
R9751	T32335	T32331	pobj	conditions,under
R9752	T32336	T32337	punct	(,scotopic
R9753	T32337	T32333	parataxis	scotopic,adapted
R9754	T32338	T32337	punct	),scotopic
R9755	T32339	T32333	cc	and,adapted
R9756	T32340	T32341	npadvmod	light,adapted
R9757	T32341	T32333	conj	adapted,adapted
R9758	T32342	T32341	punct	-,adapted
R9759	T32343	T32344	punct	(,photopic
R9760	T32344	T32341	parataxis	photopic,adapted
R9761	T32345	T32344	punct	),photopic
R9762	T32346	T32329	punct	.,obtained
R9763	T32348	T32349	compound	Light,adaptation
R9764	T32349	T32350	nsubjpass	adaptation,accomplished
R9765	T32351	T32350	auxpass	was,accomplished
R9766	T32352	T32350	prep	with,accomplished
R9767	T32353	T32354	det	a,illumination
R9768	T32354	T32352	pobj	illumination,with
R9769	T32355	T32354	compound	background,illumination
R9770	T32356	T32354	prep	of,illumination
R9771	T32357	T32358	nummod	30,candela
R9772	T32358	T32356	pobj	candela,of
R9773	T32359	T32358	punct	(,candela
R9774	T32360	T32358	appos	cd,candela
R9775	T32361	T32358	punct	),candela
R9776	T32362	T32358	prep	per,candela
R9777	T32363	T32364	amod	square,meter
R9778	T32364	T32362	pobj	meter,per
R9779	T32365	T32350	advcl	starting,accomplished
R9780	T32366	T32367	nummod	10,min
R9781	T32367	T32368	npadvmod	min,before
R9782	T32368	T32365	prep	before,starting
R9783	T32369	T32368	pobj	recording,before
R9784	T32370	T32350	punct	.,accomplished
R9785	T32372	T32373	amod	Single,stimulation
R9786	T32373	T32377	nsubj	stimulation,divided
R9787	T32374	T32375	amod	white,flash
R9788	T32375	T32373	compound	flash,stimulation
R9789	T32376	T32375	punct	-,flash
R9790	T32378	T32377	aux	ranged,divided
R9791	T32379	T32377	prep	from,divided
R9792	T32380	T32381	compound	10,4
R9793	T32381	T32379	pobj	4,from
R9794	T32382	T32381	punct	−,4
R9795	T32383	T32379	prep	to,from
R9796	T32384	T32383	pobj	25,to
R9797	T32385	T32386	nmod	cd,s
R9798	T32386	T32377	dobj	s,divided
R9799	T32387	T32386	punct	·,s
R9800	T32388	T32389	punct	/,m2
R9801	T32389	T32386	prep	m2,s
R9802	T32390	T32377	punct	", ",divided
R9803	T32391	T32377	prep	into,divided
R9804	T32392	T32393	nummod	ten,steps
R9805	T32393	T32391	pobj	steps,into
R9806	T32394	T32393	prep	of,steps
R9807	T32395	T32394	pobj	0.5,of
R9808	T32396	T32395	cc	and,0.5
R9809	T32397	T32395	conj	1,0.5
R9810	T32398	T32399	nmod	log,cd
R9811	T32399	T32400	nmod	cd,s
R9812	T32400	T32395	appos	s,0.5
R9813	T32401	T32400	punct	·,s
R9814	T32402	T32403	punct	/,m2
R9815	T32403	T32395	prep	m2,0.5
R9816	T32404	T32377	punct	.,divided
R9817	T32406	T32407	nummod	Ten,responses
R9818	T32407	T32408	nsubjpass	responses,averaged
R9819	T32409	T32408	auxpass	were,averaged
R9820	T32410	T32408	prep	with,averaged
R9821	T32411	T32412	det	an,interval
R9822	T32412	T32410	pobj	interval,with
R9823	T32413	T32412	amod	inter-stimulus,interval
R9824	T32414	T32412	prep	of,interval
R9825	T32415	T32416	preconj	either,s
R9826	T32416	T32414	pobj	s,of
R9827	T32417	T32416	nummod	5,s
R9828	T32418	T32416	punct	(,s
R9829	T32419	T32416	prep	for,s
R9830	T32420	T32421	quantmod	10,4
R9831	T32421	T32423	nummod	4,s
R9832	T32422	T32421	punct	−,4
R9833	T32423	T32419	pobj	s,for
R9834	T32424	T32421	punct	", ",4
R9835	T32425	T32426	quantmod	10,3
R9836	T32426	T32421	conj	3,4
R9837	T32427	T32426	punct	−,3
R9838	T32428	T32426	punct	", ",3
R9839	T32429	T32430	quantmod	10,2
R9840	T32430	T32426	conj	2,3
R9841	T32431	T32430	punct	−,2
R9842	T32432	T32430	punct	", ",2
R9843	T32433	T32434	quantmod	3,2
R9844	T32434	T32430	conj	2,2
R9845	T32435	T32434	punct	×,2
R9846	T32436	T32434	quantmod	10,2
R9847	T32437	T32434	punct	−,2
R9848	T32438	T32434	punct	", ",2
R9849	T32439	T32440	quantmod	10,1
R9850	T32440	T32434	conj	1,2
R9851	T32441	T32440	punct	−,1
R9852	T32442	T32440	punct	", ",1
R9853	T32443	T32440	cc	and,1
R9854	T32444	T32445	quantmod	3,1
R9855	T32445	T32440	conj	1,1
R9856	T32446	T32445	punct	×,1
R9857	T32447	T32445	quantmod	10,1
R9858	T32448	T32445	punct	−,1
R9859	T32449	T32423	nmod	cd,s
R9860	T32450	T32423	punct	·,s
R9861	T32451	T32452	punct	/,m2
R9862	T32452	T32423	prep	m2,s
R9863	T32453	T32416	punct	),s
R9864	T32454	T32416	cc	or,s
R9865	T32455	T32456	nummod	17,s
R9866	T32456	T32416	conj	s,s
R9867	T32457	T32456	punct	(,s
R9868	T32458	T32456	prep	for,s
R9869	T32459	T32460	nummod	1,s
R9870	T32460	T32458	pobj	s,for
R9871	T32461	T32459	punct	", ",1
R9872	T32462	T32459	conj	3,1
R9873	T32463	T32462	punct	", ",3
R9874	T32464	T32462	conj	10,3
R9875	T32465	T32464	punct	", ",10
R9876	T32466	T32464	cc	and,10
R9877	T32467	T32464	conj	25,10
R9878	T32468	T32460	nmod	cd,s
R9879	T32469	T32460	punct	·,s
R9880	T32470	T32471	punct	/,m2
R9881	T32471	T32460	prep	m2,s
R9882	T32472	T32408	punct	),averaged
R9883	T32473	T32408	punct	.,averaged
R9884	T32475	T32476	nmod	Band,pass
R9885	T32476	T32478	nmod	pass,filter
R9886	T32477	T32476	punct	-,pass
R9887	T32478	T32479	nmod	filter,frequencies
R9888	T32479	T32483	nsubj	frequencies,were
R9889	T32480	T32479	amod	cut,frequencies
R9890	T32481	T32480	punct	-,cut
R9891	T32482	T32480	prt	off,cut
R9892	T32484	T32485	nummod	0.1,Hz
R9893	T32485	T32483	attr	Hz,were
R9894	T32486	T32484	cc	and,0.1
R9895	T32487	T32484	conj	"3,000",0.1
R9896	T32488	T32483	punct	.,were
R9923	T32582	T32580	parataxis	program,test
R9925	T32584	T32582	punct	", ",program
R9926	T32585	T32582	npadvmod	http://www.xlstat.com,program
R9927	T32586	T32582	punct	),program
R9928	T32587	T32558	punct	.,evaluated
R9941	T33426	T33427	nmod	E2f1,Loss
R9942	T33427	T33435	nsubj	Loss,Rescues
R9943	T33428	T33426	punct	", ",E2f1
R9944	T33429	T33426	cc	but,E2f1
R9945	T33430	T33429	neg	Not,but
R9946	T33431	T33426	conj	E2f2,E2f1
R9947	T33432	T33431	cc	or,E2f2
R9948	T33433	T33431	conj	E2f3,E2f2
R9949	T33434	T33427	punct	", ",Loss
R9950	T33436	T33437	amod	Ectopic,Division
R9951	T33437	T33435	dobj	Division,Rescues
R9952	T33438	T33437	cc	and,Division
R9953	T33439	T33440	compound	Cell,Death
R9954	T33440	T33437	conj	Death,Division
R9955	T33441	T33435	prep	in,Rescues
R9956	T33442	T33443	det	the,Retina
R9957	T33443	T33441	pobj	Retina,in
R9958	T33444	T33445	compound	Rb,KO
R9959	T33445	T33443	compound	KO,Retina
R9960	T33447	T33448	punct	(,A
R9961	T33448	T33449	meta	A,development
R9962	T33450	T33448	punct	),A
R9963	T33451	T33449	amod	Retinal,development
R9964	T33452	T33449	punct	.,development
R9965	T33454	T33455	prep	At,is
R9966	T33456	T33454	pobj	E11,At
R9967	T33457	T33458	det	the,retina
R9968	T33458	T33455	nsubj	retina,is
R9969	T33459	T33460	det	a,NBL
R9970	T33460	T33455	attr	NBL,is
R9971	T33461	T33460	prep	of,NBL
R9972	T33462	T33463	amod	dividing,RPCs
R9973	T33463	T33461	pobj	RPCs,of
R9974	T33464	T33465	punct	(,nuclei
R9975	T33465	T33455	parataxis	nuclei,is
R9976	T33466	T33467	amod	white,circle
R9977	T33467	T33465	dep	circle,nuclei
R9978	T33468	T33465	punct	", ",nuclei
R9979	T33469	T33465	amod	green,nuclei
R9980	T33470	T33465	punct	),nuclei
R9981	T33471	T33455	punct	.,is
R9982	T33473	T33474	compound	RPC,bodies
R9983	T33474	T33476	nsubj	bodies,oscillate
R9984	T33475	T33474	compound	cell,bodies
R9985	T33477	T33476	prep	along,oscillate
R9986	T33478	T33477	pobj	processes,along
R9987	T33479	T33480	mark	as,progress
R9988	T33480	T33476	advcl	progress,oscillate
R9989	T33481	T33480	nsubj	they,progress
R9990	T33482	T33480	prep	through,progress
R9991	T33483	T33484	det	the,cycle
R9992	T33484	T33482	pobj	cycle,through
R9993	T33485	T33484	compound	cell,cycle
R9994	T33486	T33476	punct	.,oscillate
R9995	T33488	T33489	prep	By,contains
R9996	T33490	T33488	pobj	P0,By
R9997	T33491	T33492	det	the,NBL
R9998	T33492	T33489	nsubj	NBL,contains
R9999	T33493	T33494	preconj	both,RPCs
R10000	T33494	T33489	dobj	RPCs,contains
R10001	T33495	T33494	cc	and,RPCs
R10002	T33496	T33497	amod	post-mitotic,RTCs
R10003	T33497	T33494	conj	RTCs,RPCs
R10004	T33498	T33499	punct	(,nuclei
R10005	T33499	T33489	parataxis	nuclei,contains
R10006	T33500	T33501	amod	coloured,circles
R10007	T33501	T33499	dep	circles,nuclei
R10008	T33502	T33499	punct	", ",nuclei
R10009	T33503	T33499	amod	red,nuclei
R10010	T33504	T33499	punct	),nuclei
R10011	T33505	T33489	cc	and,contains
R10012	T33506	T33507	auxpass	is,separated
R10013	T33507	T33489	conj	separated,contains
R10014	T33508	T33507	prep	from,separated
R10015	T33509	T33510	det	the,GCL
R10016	T33510	T33508	pobj	GCL,from
R10017	T33511	T33507	agent	by,separated
R10018	T33512	T33513	det	the,IPL
R10019	T33513	T33511	pobj	IPL,by
R10020	T33514	T33489	punct	.,contains
R10021	T33516	T33517	prep	By,are
R10022	T33518	T33516	pobj	P8,By
R10023	T33519	T33517	expl	there,are
R10024	T33520	T33521	det	no,RPCs
R10025	T33521	T33517	attr	RPCs,are
R10026	T33522	T33521	punct	", ",RPCs
R10027	T33523	T33524	amod	fewer,RTCs
R10028	T33524	T33521	conj	RTCs,RPCs
R10029	T33525	T33524	punct	", ",RTCs
R10030	T33526	T33527	det	an,OPL
R10031	T33527	T33524	conj	OPL,RTCs
R10032	T33528	T33527	punct	", ",OPL
R10033	T33529	T33527	cc	and,OPL
R10034	T33530	T33531	amod	more,rods
R10035	T33531	T33527	conj	rods,OPL
R10036	T33532	T33531	amod	differentiated,rods
R10037	T33533	T33531	punct	(,rods
R10038	T33534	T33531	appos	r,rods
R10039	T33535	T33531	punct	),rods
R10040	T33536	T33531	cc	and,rods
R10041	T33537	T33531	conj	cones,rods
R10042	T33538	T33537	punct	(,cones
R10043	T33539	T33537	appos	c,cones
R10044	T33540	T33517	punct	),are
R10045	T33541	T33517	prep	in,are
R10046	T33542	T33543	det	the,ONL
R10047	T33543	T33541	pobj	ONL,in
R10048	T33544	T33517	punct	;,are
R10049	T33545	T33546	amod	horizontal,cells
R10050	T33546	T33517	conj	cells,are
R10051	T33547	T33548	punct	(,h
R10052	T33548	T33545	parataxis	h,horizontal
R10053	T33549	T33548	punct	),h
R10054	T33550	T33545	punct	", ",horizontal
R10055	T33551	T33545	conj	bipolar,horizontal
R10056	T33552	T33553	punct	(,b
R10057	T33553	T33551	parataxis	b,bipolar
R10058	T33554	T33553	punct	),b
R10059	T33555	T33551	punct	", ",bipolar
R10060	T33556	T33551	conj	Müller,bipolar
R10061	T33557	T33556	punct	(,Müller
R10062	T33558	T33556	appos	m,Müller
R10063	T33559	T33556	punct	),Müller
R10064	T33560	T33556	punct	", ",Müller
R10065	T33561	T33556	cc	and,Müller
R10066	T33562	T33556	conj	amacrine,Müller
R10067	T33563	T33564	punct	(,a
R10068	T33564	T33562	parataxis	a,amacrine
R10069	T33565	T33564	punct	),a
R10070	T33566	T33546	prep	in,cells
R10071	T33567	T33568	det	the,INL
R10072	T33568	T33566	pobj	INL,in
R10073	T33569	T33546	punct	;,cells
R10074	T33570	T33546	cc	and,cells
R10075	T33571	T33546	conj	ganglion,cells
R10076	T33572	T33571	punct	(,ganglion
R10077	T33573	T33571	appos	g,ganglion
R10078	T33574	T33571	punct	),ganglion
R10079	T33575	T33571	cc	and,ganglion
R10080	T33576	T33577	amod	displaced,amacrine
R10081	T33577	T33578	nmod	amacrine,cells
R10082	T33578	T33571	conj	cells,ganglion
R10083	T33579	T33571	prep	in,ganglion
R10084	T33580	T33581	det	the,GCL
R10085	T33581	T33579	pobj	GCL,in
R10086	T33582	T33517	punct	.,are
R10087	T33584	T33585	nsubj	Development,is
R10088	T33586	T33585	acomp	complete,is
R10089	T33587	T33585	prep	by,is
R10090	T33588	T33589	punct	~,P18
R10091	T33589	T33587	pobj	P18,by
R10092	T33590	T33585	punct	.,is
R10093	T33592	T33593	punct	(,B
R10094	T33593	T33594	meta	B,thought
R10095	T33595	T33593	punct	),B
R10096	T33596	T33594	nsubjpass	Rb,thought
R10097	T33597	T33594	auxpass	is,thought
R10098	T33598	T33599	aux	to,regulate
R10099	T33599	T33594	xcomp	regulate,thought
R10100	T33600	T33601	compound	cell,cycle
R10101	T33601	T33599	dobj	cycle,regulate
R10102	T33602	T33601	cc	and,cycle
R10103	T33603	T33601	conj	apoptosis,cycle
R10104	T33604	T33599	prep	by,regulate
R10105	T33605	T33604	pcomp	repressing,by
R10106	T33606	T33605	dobj	E2fs,repressing
R10107	T33607	T33599	punct	", ",regulate
R10108	T33608	T33599	cc	but,regulate
R10109	T33609	T33610	aux	to,promote
R10110	T33610	T33599	conj	promote,regulate
R10111	T33611	T33610	dobj	differentiation,promote
R10112	T33612	T33611	prep	by,differentiation
R10113	T33613	T33612	pcomp	potentiating,by
R10114	T33614	T33615	npadvmod	tissue,specific
R10115	T33615	T33617	amod	specific,factors
R10116	T33616	T33615	punct	-,specific
R10117	T33617	T33613	dobj	factors,potentiating
R10118	T33618	T33617	compound	transcription,factors
R10119	T33619	T33594	punct	.,thought
R10120	T33621	T33622	advmod	However,perturb
R10121	T33623	T33622	punct	", ",perturb
R10122	T33624	T33625	compound	Rb,loss
R10123	T33625	T33622	nsubj	loss,perturb
R10124	T33626	T33622	aux	could,perturb
R10125	T33627	T33622	advmod	also,perturb
R10126	T33628	T33622	dobj	differentiation,perturb
R10127	T33629	T33622	prep	through,perturb
R10128	T33630	T33631	det	the,effects
R10129	T33631	T33629	pobj	effects,through
R10130	T33632	T33631	amod	indirect,effects
R10131	T33633	T33631	prep	of,effects
R10132	T33634	T33635	amod	abnormal,division
R10133	T33635	T33633	pobj	division,of
R10134	T33636	T33635	cc	or,division
R10135	T33637	T33635	conj	death,division
R10136	T33638	T33629	punct	", ",through
R10137	T33639	T33629	cc	and,through
R10138	T33640	T33639	punct	/,and
R10139	T33641	T33639	cc	or,and
R10140	T33642	T33629	conj	through,through
R10141	T33643	T33644	amod	direct,regulation
R10142	T33644	T33642	pobj	regulation,through
R10143	T33645	T33644	prep	of,regulation
R10144	T33646	T33647	compound	differentiation,genes
R10145	T33647	T33645	pobj	genes,of
R10146	T33648	T33644	prep	by,regulation
R10147	T33649	T33648	pobj	E2fs,by
R10148	T33650	T33622	punct	.,perturb
R10149	T33652	T33653	punct	(,C
R10150	T33653	T33654	meta	C,stained
R10151	T33655	T33653	cc	and,C
R10152	T33656	T33653	conj	D,C
R10153	T33657	T33656	punct	),D
R10154	T33658	T33659	amod	Horizontal,sections
R10155	T33659	T33654	nsubjpass	sections,stained
R10156	T33660	T33659	amod	retinal,sections
R10157	T33661	T33659	prep	of,sections
R10158	T33662	T33663	det	the,genotypes
R10159	T33663	T33661	pobj	genotypes,of
R10160	T33664	T33663	amod	indicated,genotypes
R10161	T33665	T33663	cc	and,genotypes
R10162	T33666	T33663	conj	ages,genotypes
R10163	T33667	T33654	auxpass	were,stained
R10164	T33668	T33654	prep	for,stained
R10165	T33669	T33668	pobj	nuclei,for
R10166	T33670	T33671	punct	(,blue
R10167	T33671	T33669	parataxis	blue,nuclei
R10168	T33672	T33671	dep	DAPI,blue
R10169	T33673	T33671	punct	", ",blue
R10170	T33674	T33671	punct	),blue
R10171	T33675	T33669	punct	", ",nuclei
R10172	T33676	T33669	cc	and,nuclei
R10173	T33677	T33678	punct	(,C
R10174	T33678	T33679	parataxis	C,phase
R10175	T33679	T33669	conj	phase,nuclei
R10176	T33680	T33678	punct	),C
R10177	T33681	T33679	compound	S,phase
R10178	T33682	T33679	punct	-,phase
R10179	T33683	T33684	punct	(,red
R10180	T33684	T33679	parataxis	red,phase
R10181	T33685	T33684	amod	anti-BrdU,red
R10182	T33686	T33684	punct	", ",red
R10183	T33687	T33684	punct	),red
R10184	T33688	T33679	cc	or,phase
R10185	T33689	T33690	punct	(,D
R10186	T33690	T33691	parataxis	D,apoptosis
R10187	T33691	T33679	conj	apoptosis,phase
R10188	T33692	T33690	punct	),D
R10189	T33693	T33694	punct	(,red
R10190	T33694	T33691	parataxis	red,apoptosis
R10191	T33695	T33694	dep	TUNEL,red
R10192	T33696	T33694	punct	", ",red
R10193	T33697	T33694	punct	),red
R10194	T33698	T33654	punct	.,stained
R10195	T33700	T33701	compound	Scale,bars
R10196	T33701	T33702	nsubj	bars,are
R10197	T33703	T33704	nummod	50,μm
R10198	T33704	T33702	attr	μm,are
R10199	T33705	T33702	punct	.,are
R10200	T33707	T33708	punct	(,E
R10201	T33708	T33709	meta	E,Quantification
R10202	T33710	T33708	punct	–,E
R10203	T33711	T33708	dep	G,E
R10204	T33712	T33708	punct	),E
R10205	T33713	T33709	prep	of,Quantification
R10206	T33714	T33715	punct	(,E
R10207	T33715	T33716	parataxis	E,cells
R10208	T33716	T33713	pobj	cells,of
R10209	T33717	T33715	punct	),E
R10210	T33718	T33716	det	all,cells
R10211	T33719	T33716	nmod	BrdU,cells
R10212	T33720	T33719	punct	+,BrdU
R10213	T33721	T33716	punct	", ",cells
R10214	T33722	T33723	punct	(,F
R10215	T33723	T33724	parataxis	F,cells
R10216	T33724	T33716	conj	cells,cells
R10217	T33725	T33723	punct	),F
R10218	T33726	T33724	amod	ectopic,cells
R10219	T33727	T33724	nmod	BrdU,cells
R10220	T33728	T33727	punct	+,BrdU
R10221	T33729	T33724	prep	in,cells
R10222	T33730	T33729	pobj	GCL,in
R10223	T33731	T33724	prep	at,cells
R10224	T33732	T33731	pobj	P0,at
R10225	T33733	T33724	punct	", ",cells
R10226	T33734	T33724	cc	and,cells
R10227	T33735	T33736	punct	(,G
R10228	T33736	T33737	parataxis	G,cells
R10229	T33737	T33724	conj	cells,cells
R10230	T33738	T33736	punct	),G
R10231	T33739	T33737	amod	total,cells
R10232	T33740	T33737	nmod	TUNEL,cells
R10233	T33741	T33740	punct	+,TUNEL
R10234	T33742	T33709	punct	.,Quantification
R10235	T33744	T33745	punct	(,H
R10236	T33745	T33746	meta	H,analysis
R10237	T33747	T33745	punct	),H
R10238	T33748	T33749	amod	Real,time
R10239	T33749	T33751	compound	time,PCR
R10240	T33750	T33749	punct	-,time
R10241	T33751	T33746	compound	PCR,analysis
R10242	T33752	T33751	compound	RT,PCR
R10243	T33753	T33751	punct	-,PCR
R10244	T33754	T33746	prep	of,analysis
R10245	T33755	T33754	pobj	E2fs,of
R10246	T33756	T33755	cc	and,E2fs
R10247	T33757	T33758	compound	E2f,genes
R10248	T33758	T33755	conj	genes,E2fs
R10249	T33759	T33758	compound	target,genes
R10250	T33760	T33746	prep	in,analysis
R10251	T33761	T33762	compound	P8,retinas
R10252	T33762	T33760	pobj	retinas,in
R10253	T33763	T33762	prep	of,retinas
R10254	T33764	T33765	det	the,genotypes
R10255	T33765	T33763	pobj	genotypes,of
R10256	T33766	T33765	amod	indicated,genotypes
R10257	T33767	T33746	punct	.,analysis
R10258	T33769	T33770	compound	Error,bars
R10259	T33770	T33771	nsubj	bars,represent
R10260	T33772	T33771	dobj	SD,represent
R10261	T33773	T33772	prep	of,SD
R10262	T33774	T33773	pobj	measurements,of
R10263	T33775	T33774	prep	from,measurements
R10264	T33776	T33777	nummod	three,animals
R10265	T33777	T33775	pobj	animals,from
R10266	T33778	T33771	punct	", ",represent
R10267	T33779	T33771	cc	and,represent
R10268	T33780	T33781	nsubj	asterisks,indicate
R10269	T33781	T33771	conj	indicate,represent
R10270	T33782	T33783	det	a,difference
R10271	T33783	T33781	dobj	difference,indicate
R10272	T33784	T33783	amod	significant,difference
R10273	T33785	T33783	prep	between,difference
R10274	T33786	T33787	det	the,genotypes
R10275	T33787	T33785	pobj	genotypes,between
R10276	T33788	T33787	nmod	WT,genotypes
R10277	T33789	T33788	cc	and,WT
R10278	T33790	T33788	conj	indicated,WT
R10279	T33791	T33792	punct	(,test
R10280	T33792	T33781	parataxis	test,indicate
R10281	T33793	T33794	punct	*,0.05
R10282	T33794	T33792	ccomp	0.05,test
R10283	T33795	T33794	punct	", ",0.05
R10284	T33796	T33794	nsubj	p,0.05
R10285	T33797	T33794	punct	<,0.05
R10286	T33798	T33792	punct	;,test
R10287	T33799	T33800	punct	**,0.01
R10288	T33800	T33792	ccomp	0.01,test
R10289	T33801	T33800	punct	;,0.01
R10290	T33802	T33800	nsubj	p,0.01
R10291	T33803	T33800	punct	<,0.01
R10292	T33804	T33792	punct	;,test
R10293	T33805	T33792	nmod	ANOVA,test
R10294	T33806	T33805	cc	and,ANOVA
R10295	T33807	T33808	compound	Tukey,HSD
R10296	T33808	T33805	conj	HSD,ANOVA
R10297	T33809	T33792	prep	for,test
R10298	T33810	T33809	punct	[,for
R10299	T33811	T33809	pobj	E,for
R10300	T33812	T33813	punct	–,G
R10301	T33813	T33811	prep	G,E
R10302	T33814	T33792	punct	],test
R10303	T33815	T33792	cc	and,test
R10304	T33816	T33817	compound	Fisher,test
R10305	T33817	T33792	conj	test,test
R10306	T33818	T33817	prep	for,test
R10307	T33819	T33818	punct	[,for
R10308	T33820	T33818	pobj	H,for
R10309	T33821	T33792	punct	],test
R10310	T33822	T33792	punct	),test
R10311	T33823	T33781	punct	.,indicate
R10316	T34416	T34417	compound	E2f1,Deletion
R10317	T34417	T34418	nsubj	Deletion,Rescues
R10318	T34419	T34420	nmod	Ganglion,Cells
R10319	T34420	T34418	dobj	Cells,Rescues
R10320	T34421	T34419	punct	", ",Ganglion
R10321	T34422	T34419	conj	Rod,Ganglion
R10322	T34423	T34422	punct	", ",Rod
R10323	T34424	T34422	cc	and,Rod
R10324	T34425	T34422	conj	Bipolar,Rod
R10325	T34426	T34418	prep	in,Rescues
R10326	T34427	T34428	det	the,Retina
R10327	T34428	T34426	pobj	Retina,in
R10328	T34429	T34430	compound	Rb,KO
R10329	T34430	T34428	compound	KO,Retina
R10330	T34432	T34433	punct	(,A
R10331	T34433	T34434	meta	A,stained
R10332	T34435	T34433	punct	),A
R10333	T34436	T34437	amod	Horizontal,sections
R10334	T34437	T34434	nsubjpass	sections,stained
R10335	T34438	T34437	amod	retinal,sections
R10336	T34439	T34437	prep	from,sections
R10337	T34440	T34439	pobj	mice,from
R10338	T34441	T34440	prep	of,mice
R10339	T34442	T34443	det	the,ages
R10340	T34443	T34441	pobj	ages,of
R10341	T34444	T34443	amod	indicated,ages
R10342	T34445	T34443	cc	and,ages
R10343	T34446	T34443	conj	genotypes,ages
R10344	T34447	T34434	auxpass	were,stained
R10345	T34448	T34434	prep	for,stained
R10346	T34449	T34448	pobj	nuclei,for
R10347	T34450	T34451	punct	(,blue
R10348	T34451	T34449	parataxis	blue,nuclei
R10349	T34452	T34451	dep	DAPI,blue
R10350	T34453	T34451	punct	", ",blue
R10351	T34454	T34451	punct	),blue
R10352	T34455	T34449	cc	and,nuclei
R10353	T34456	T34449	conj	markers,nuclei
R10354	T34457	T34458	dep	that,detect
R10355	T34458	T34456	relcl	detect,markers
R10356	T34459	T34460	compound	ganglion,cells
R10357	T34460	T34458	dobj	cells,detect
R10358	T34461	T34462	punct	(,red
R10359	T34462	T34460	parataxis	red,cells
R10360	T34463	T34462	dep	Pou4f2,red
R10361	T34464	T34462	punct	", ",red
R10362	T34465	T34462	punct	),red
R10363	T34466	T34460	punct	", ",cells
R10364	T34467	T34460	conj	rods,cells
R10365	T34468	T34467	cc	and,rods
R10366	T34469	T34467	conj	cones,rods
R10367	T34470	T34471	punct	(,green
R10368	T34471	T34469	parataxis	green,cones
R10369	T34472	T34471	dep	Sag,green
R10370	T34473	T34471	punct	[,green
R10371	T34474	T34475	compound	rod,arrestin
R10372	T34475	T34471	dep	arrestin,green
R10373	T34476	T34471	punct	],green
R10374	T34477	T34471	punct	", ",green
R10375	T34478	T34471	punct	),green
R10376	T34479	T34467	punct	", ",rods
R10377	T34480	T34467	cc	and,rods
R10378	T34481	T34482	nmod	rod,cells
R10379	T34482	T34467	conj	cells,rods
R10380	T34483	T34482	amod	bipolar,cells
R10381	T34484	T34485	punct	(,green
R10382	T34485	T34482	parataxis	green,cells
R10383	T34486	T34485	dep	Prkca,green
R10384	T34487	T34485	punct	", ",green
R10385	T34488	T34485	punct	", ",green
R10386	T34489	T34485	cc	and,green
R10387	T34490	T34491	dep	Cabp5,red
R10388	T34491	T34485	conj	red,green
R10389	T34492	T34491	punct	", ",red
R10390	T34493	T34491	punct	),red
R10391	T34494	T34434	punct	.,stained
R10392	T34496	T34497	compound	Scale,bars
R10393	T34497	T34498	nsubj	bars,are
R10394	T34499	T34500	nummod	50,μm
R10395	T34500	T34498	attr	μm,are
R10396	T34501	T34498	punct	.,are
R10397	T34503	T34504	punct	(,B
R10398	T34504	T34505	meta	B,Quantification
R10399	T34506	T34504	punct	),B
R10400	T34507	T34505	prep	of,Quantification
R10401	T34508	T34509	nmod	Pou4f2,cells
R10402	T34509	T34507	pobj	cells,of
R10403	T34510	T34508	punct	+,Pou4f2
R10404	T34511	T34509	compound	ganglion,cells
R10405	T34512	T34505	punct	.,Quantification
R10406	T34514	T34515	punct	(,C
R10407	T34515	T34516	meta	C,Quantification
R10408	T34517	T34515	punct	),C
R10409	T34518	T34516	prep	of,Quantification
R10410	T34519	T34520	nmod	Prkca,cells
R10411	T34520	T34518	pobj	cells,of
R10412	T34521	T34519	punct	+,Prkca
R10413	T34522	T34519	cc	and,Prkca
R10414	T34523	T34519	conj	Cabp5,Prkca
R10415	T34524	T34523	punct	+,Cabp5
R10416	T34525	T34520	amod	bipolar,cells
R10417	T34526	T34516	punct	.,Quantification
R10418	T34528	T34529	punct	(,D
R10419	T34529	T34530	meta	D,Thickness
R10420	T34531	T34529	punct	),D
R10421	T34532	T34530	prep	of,Thickness
R10422	T34533	T34534	det	the,ONL
R10423	T34534	T34532	pobj	ONL,of
R10424	T34535	T34534	punct	", ",ONL
R10425	T34536	T34537	dep	which,represents
R10426	T34537	T34534	relcl	represents,ONL
R10427	T34538	T34539	det	the,number
R10428	T34539	T34537	dobj	number,represents
R10429	T34540	T34539	prep	of,number
R10430	T34541	T34540	pobj	rods,of
R10431	T34542	T34530	punct	.,Thickness
R10432	T34544	T34545	compound	Error,bars
R10433	T34545	T34546	nsubj	bars,represent
R10434	T34547	T34546	dobj	SD,represent
R10435	T34548	T34547	prep	of,SD
R10436	T34549	T34548	pobj	measurements,of
R10437	T34550	T34549	prep	from,measurements
R10438	T34551	T34552	nummod	three,animals
R10439	T34552	T34550	pobj	animals,from
R10440	T34553	T34546	punct	", ",represent
R10441	T34554	T34546	cc	and,represent
R10442	T34555	T34556	nsubj	asterisks,indicate
R10443	T34556	T34546	conj	indicate,represent
R10444	T34557	T34558	det	a,difference
R10445	T34558	T34556	dobj	difference,indicate
R10446	T34559	T34558	amod	significant,difference
R10447	T34560	T34558	prep	between,difference
R10448	T34561	T34560	pobj	retinas,between
R10449	T34562	T34561	prep	of,retinas
R10450	T34563	T34562	pobj	WT,of
R10451	T34564	T34563	cc	and,WT
R10452	T34565	T34566	det	the,indicated
R10453	T34566	T34567	nmod	indicated,genotypes
R10454	T34567	T34563	conj	genotypes,WT
R10455	T34568	T34556	punct	", ",indicate
R10456	T34569	T34570	mark	unless,indicated
R10457	T34570	T34556	advcl	indicated,indicate
R10458	T34571	T34570	advmod	otherwise,indicated
R10459	T34572	T34570	agent	by,indicated
R10460	T34573	T34574	amod	connecting,lines
R10461	T34574	T34572	pobj	lines,by
R10462	T34575	T34576	punct	(,test
R10463	T34576	T34556	parataxis	test,indicate
R10464	T34577	T34578	punct	*,0.05
R10465	T34578	T34576	ccomp	0.05,test
R10466	T34579	T34578	punct	", ",0.05
R10467	T34580	T34578	nsubj	p,0.05
R10468	T34581	T34578	punct	<,0.05
R10469	T34582	T34576	punct	;,test
R10470	T34583	T34584	punct	**,0.01
R10471	T34584	T34576	ccomp	0.01,test
R10472	T34585	T34584	punct	;,0.01
R10473	T34586	T34584	nsubj	p,0.01
R10474	T34587	T34584	punct	<,0.01
R10475	T34588	T34576	punct	;,test
R10476	T34589	T34576	nmod	ANOVA,test
R10477	T34590	T34589	cc	and,ANOVA
R10478	T34591	T34592	compound	Tukey,HSD
R10479	T34592	T34589	conj	HSD,ANOVA
R10480	T34593	T34576	punct	),test
R10481	T34594	T34556	punct	.,indicate
R10482	T34596	T34597	punct	(,E
R10483	T34597	T34598	meta	E,recorded
R10484	T34599	T34597	cc	and,E
R10485	T34600	T34597	conj	F,E
R10486	T34601	T34600	punct	),F
R10487	T34602	T34598	nsubjpass	ERGs,recorded
R10488	T34603	T34598	auxpass	were,recorded
R10489	T34604	T34598	prep	from,recorded
R10490	T34605	T34606	det	the,genotypes
R10491	T34606	T34604	pobj	genotypes,from
R10492	T34607	T34606	amod	indicated,genotypes
R10493	T34608	T34598	prep	under,recorded
R10494	T34609	T34610	npadvmod	dark,adapted
R10495	T34610	T34612	amod	adapted,conditions
R10496	T34611	T34610	punct	-,adapted
R10497	T34612	T34608	pobj	conditions,under
R10498	T34613	T34614	punct	(,scotopic
R10499	T34614	T34610	parataxis	scotopic,adapted
R10500	T34615	T34614	punct	),scotopic
R10501	T34616	T34598	punct	", ",recorded
R10502	T34617	T34598	cc	and,recorded
R10503	T34618	T34619	punct	(,E
R10504	T34619	T34620	parataxis	E,series
R10505	T34620	T34623	nsubjpass	series,determined
R10506	T34621	T34619	punct	),E
R10507	T34622	T34620	compound	intensity,series
R10508	T34623	T34598	conj	determined,recorded
R10509	T34624	T34620	cc	and,series
R10510	T34625	T34626	punct	(,F
R10511	T34626	T34627	parataxis	F,amplitudes
R10512	T34627	T34620	conj	amplitudes,series
R10513	T34628	T34626	punct	),F
R10514	T34629	T34630	compound	b,wave
R10515	T34630	T34627	compound	wave,amplitudes
R10516	T34631	T34630	punct	-,wave
R10517	T34632	T34620	prep	as,series
R10518	T34633	T34634	det	a,function
R10519	T34634	T34632	pobj	function,as
R10520	T34635	T34634	prep	of,function
R10521	T34636	T34637	det	the,logarithm
R10522	T34637	T34635	pobj	logarithm,of
R10523	T34638	T34637	prep	of,logarithm
R10524	T34639	T34640	det	the,intensity
R10525	T34640	T34638	pobj	intensity,of
R10526	T34641	T34640	compound	flash,intensity
R10527	T34642	T34623	auxpass	were,determined
R10528	T34643	T34623	punct	.,determined
R10529	T34645	T34646	punct	(,illustrates
R10530	T34647	T34646	nsubj	F,illustrates
R10531	T34648	T34646	punct	),illustrates
R10532	T34649	T34646	advmod	Further,illustrates
R10533	T34650	T34651	mark	that,was
R10534	T34651	T34646	ccomp	was,illustrates
R10535	T34652	T34653	det	the,influence
R10536	T34653	T34651	nsubj	influence,was
R10537	T34654	T34653	amod	relative,influence
R10538	T34655	T34653	prep	of,influence
R10539	T34656	T34657	det	the,mutations
R10540	T34657	T34655	pobj	mutations,of
R10541	T34658	T34653	prep	on,influence
R10542	T34659	T34660	det	the,photoreceptors
R10543	T34660	T34658	pobj	photoreceptors,on
R10544	T34661	T34660	punct	(,photoreceptors
R10545	T34662	T34660	acl	indicated,photoreceptors
R10546	T34663	T34662	agent	by,indicated
R10547	T34664	T34665	det	the,amplitude
R10548	T34665	T34663	pobj	amplitude,by
R10549	T34666	T34665	amod	saturated,amplitude
R10550	T34667	T34668	compound	a,wave
R10551	T34668	T34665	compound	wave,amplitude
R10552	T34669	T34668	punct	-,wave
R10553	T34670	T34671	punct	", ",graph
R10554	T34671	T34662	parataxis	graph,indicated
R10555	T34672	T34671	amod	right,graph
R10556	T34673	T34671	punct	),graph
R10557	T34674	T34651	neg	not,was
R10558	T34675	T34676	advmod	substantially,different
R10559	T34676	T34651	acomp	different,was
R10560	T34677	T34676	prep	from,different
R10561	T34678	T34679	poss	their,effect
R10562	T34679	T34677	pobj	effect,from
R10563	T34680	T34679	prep	on,effect
R10564	T34681	T34682	det	the,response
R10565	T34682	T34680	pobj	response,on
R10566	T34683	T34684	compound	b,wave
R10567	T34684	T34682	compound	wave,response
R10568	T34685	T34684	punct	-,wave
R10569	T34686	T34679	punct	(,effect
R10570	T34687	T34679	acl	dominated,effect
R10571	T34688	T34687	agent	by,dominated
R10572	T34689	T34690	det	the,bipolars
R10573	T34690	T34688	pobj	bipolars,by
R10574	T34691	T34692	punct	", ",graph
R10575	T34692	T34690	parataxis	graph,bipolars
R10576	T34693	T34692	amod	left,graph
R10577	T34694	T34692	punct	),graph
R10578	T34695	T34690	prep	at,bipolars
R10579	T34696	T34697	det	the,intensity
R10580	T34697	T34695	pobj	intensity,at
R10581	T34698	T34697	amod	same,intensity
R10582	T34699	T34697	prep	of,intensity
R10583	T34700	T34701	nummod	10,s
R10584	T34701	T34699	pobj	s,of
R10585	T34702	T34701	nmod	cd,s
R10586	T34703	T34701	punct	·,s
R10587	T34704	T34705	punct	/,m2
R10588	T34705	T34701	prep	m2,s
R10589	T34706	T34646	punct	.,illustrates
R10590	T35125	T35126	compound	Differentiation,Defects
R10591	T35127	T35126	prep	in,Defects
R10592	T35128	T35129	compound	Rb,KO
R10593	T35129	T35130	compound	KO,SACs
R10594	T35130	T35127	pobj	SACs,in
R10595	T35132	T35133	punct	(,A
R10596	T35133	T35134	meta	A,stained
R10597	T35135	T35133	punct	),A
R10598	T35136	T35137	nmod	P18,sections
R10599	T35137	T35134	nsubjpass	sections,stained
R10600	T35138	T35137	amod	horizontal,sections
R10601	T35139	T35137	prep	of,sections
R10602	T35140	T35141	nmod	WT,retina
R10603	T35141	T35139	pobj	retina,of
R10604	T35142	T35140	punct	", ",WT
R10605	T35143	T35144	compound	Rb,KO
R10606	T35144	T35140	conj	KO,WT
R10607	T35145	T35144	punct	", ",KO
R10608	T35146	T35144	cc	and,KO
R10609	T35147	T35148	compound	Rb,E2f1
R10610	T35148	T35150	compound	E2f1,DKO
R10611	T35149	T35148	punct	/,E2f1
R10612	T35150	T35144	conj	DKO,KO
R10613	T35151	T35134	auxpass	were,stained
R10614	T35152	T35134	prep	for,stained
R10615	T35153	T35152	pobj	nuclei,for
R10616	T35154	T35155	punct	(,blue
R10617	T35155	T35153	parataxis	blue,nuclei
R10618	T35156	T35155	dep	DAPI,blue
R10619	T35157	T35155	punct	", ",blue
R10620	T35158	T35155	punct	),blue
R10621	T35159	T35153	punct	", ",nuclei
R10622	T35160	T35153	conj	Calb2,nuclei
R10623	T35161	T35162	punct	(,green
R10624	T35162	T35160	parataxis	green,Calb2
R10625	T35163	T35162	punct	),green
R10626	T35164	T35160	punct	", ",Calb2
R10627	T35165	T35160	cc	and,Calb2
R10628	T35166	T35160	conj	Slc18a3,Calb2
R10629	T35167	T35168	punct	(,red
R10630	T35168	T35166	parataxis	red,Slc18a3
R10631	T35169	T35168	punct	),red
R10632	T35170	T35134	punct	.,stained
R10633	T35172	T35173	punct	(,B
R10634	T35173	T35174	meta	B,stained
R10635	T35175	T35173	punct	),B
R10636	T35176	T35177	amod	Confocal,images
R10637	T35177	T35174	nsubjpass	images,stained
R10638	T35178	T35177	prep	of,images
R10639	T35179	T35180	nmod	P30,sections
R10640	T35180	T35178	pobj	sections,of
R10641	T35181	T35180	amod	horizontal,sections
R10642	T35182	T35180	prep	of,sections
R10643	T35183	T35184	nmod	WT,retina
R10644	T35184	T35182	pobj	retina,of
R10645	T35185	T35183	cc	and,WT
R10646	T35186	T35187	compound	Rb,KO
R10647	T35187	T35183	conj	KO,WT
R10648	T35188	T35174	auxpass	were,stained
R10649	T35189	T35174	prep	for,stained
R10650	T35190	T35189	pobj	nuclei,for
R10651	T35191	T35192	punct	(,DAPI
R10652	T35192	T35190	parataxis	DAPI,nuclei
R10653	T35193	T35192	punct	", ",DAPI
R10654	T35194	T35192	amod	blue,DAPI
R10655	T35195	T35192	punct	),DAPI
R10656	T35196	T35190	punct	", ",nuclei
R10657	T35197	T35190	conj	Chat,nuclei
R10658	T35198	T35197	cc	and,Chat
R10659	T35199	T35197	conj	Slc18a3,Chat
R10660	T35200	T35201	punct	(,red
R10661	T35201	T35199	parataxis	red,Slc18a3
R10662	T35202	T35201	advmod	both,red
R10663	T35203	T35201	punct	),red
R10664	T35204	T35197	punct	", ",Chat
R10665	T35205	T35197	cc	and,Chat
R10666	T35206	T35197	conj	Camk2a,Chat
R10667	T35207	T35208	punct	(,green
R10668	T35208	T35206	parataxis	green,Camk2a
R10669	T35209	T35208	punct	),green
R10670	T35210	T35174	punct	.,stained
R10671	T35212	T35213	prep	In,is
R10672	T35214	T35215	det	the,section
R10673	T35215	T35212	pobj	section,In
R10674	T35216	T35217	compound	Rb,KO
R10675	T35217	T35215	compound	KO,section
R10676	T35218	T35213	punct	", ",is
R10677	T35219	T35220	det	the,stain
R10678	T35220	T35213	nsubj	stain,is
R10679	T35221	T35220	amod	red,stain
R10680	T35222	T35213	attr	Chat,is
R10681	T35223	T35222	advmod	only,Chat
R10682	T35224	T35213	punct	", ",is
R10683	T35225	T35226	mark	as,missing
R10684	T35226	T35213	advcl	missing,is
R10685	T35227	T35226	nsubj	Slc18a3,missing
R10686	T35228	T35226	aux	is,missing
R10687	T35229	T35230	punct	(,see
R10688	T35230	T35213	parataxis	see,is
R10689	T35231	T35230	punct	[,see
R10690	T35232	T35230	dobj	A,see
R10691	T35233	T35230	punct	],see
R10692	T35234	T35230	punct	),see
R10693	T35235	T35213	punct	.,is
R10694	T35237	T35238	punct	(,C
R10695	T35238	T35239	meta	C,Quantification
R10696	T35240	T35238	punct	),C
R10697	T35241	T35239	prep	of,Quantification
R10698	T35242	T35243	amod	dense,bodies
R10699	T35243	T35241	pobj	bodies,of
R10700	T35244	T35243	nmod	Calb2,bodies
R10701	T35245	T35244	punct	+,Calb2
R10702	T35246	T35243	compound	cell,bodies
R10703	T35247	T35243	prep	in,bodies
R10704	T35248	T35249	det	the,INL
R10705	T35249	T35247	pobj	INL,in
R10706	T35250	T35243	punct	", ",bodies
R10707	T35251	T35252	amod	total,bodies
R10708	T35252	T35243	conj	bodies,bodies
R10709	T35253	T35252	nmod	Slc18a3,bodies
R10710	T35254	T35253	punct	+,Slc18a3
R10711	T35255	T35252	compound	cell,bodies
R10712	T35256	T35252	punct	", ",bodies
R10713	T35257	T35252	cc	and,bodies
R10714	T35258	T35259	nmod	Camk2a,bodies
R10715	T35259	T35252	conj	bodies,bodies
R10716	T35260	T35258	punct	+,Camk2a
R10717	T35261	T35259	compound	cell,bodies
R10718	T35262	T35259	prep	in,bodies
R10719	T35263	T35264	det	the,INL
R10720	T35264	T35262	pobj	INL,in
R10721	T35265	T35239	punct	.,Quantification
R10722	T35267	T35268	compound	Error,bars
R10723	T35268	T35269	nsubj	bars,represent
R10724	T35270	T35269	dobj	SD,represent
R10725	T35271	T35270	prep	of,SD
R10726	T35272	T35271	pobj	measurements,of
R10727	T35273	T35272	prep	from,measurements
R10728	T35274	T35275	nummod	three,animals
R10729	T35275	T35273	pobj	animals,from
R10730	T35276	T35269	punct	", ",represent
R10731	T35277	T35269	cc	and,represent
R10732	T35278	T35279	nsubj	asterisks,indicate
R10733	T35279	T35269	conj	indicate,represent
R10734	T35280	T35281	amod	significant,differences
R10735	T35281	T35279	dobj	differences,indicate
R10736	T35282	T35281	prep	between,differences
R10737	T35283	T35282	pobj	retinas,between
R10738	T35284	T35283	prep	of,retinas
R10739	T35285	T35284	pobj	WT,of
R10740	T35286	T35285	cc	and,WT
R10741	T35287	T35288	det	the,genotypes
R10742	T35288	T35285	conj	genotypes,WT
R10743	T35289	T35288	amod	indicated,genotypes
R10744	T35290	T35291	punct	(,test
R10745	T35291	T35279	parataxis	test,indicate
R10746	T35292	T35293	punct	*,0.05
R10747	T35293	T35291	ccomp	0.05,test
R10748	T35294	T35293	punct	", ",0.05
R10749	T35295	T35293	nsubj	p,0.05
R10750	T35296	T35293	punct	<,0.05
R10751	T35297	T35291	punct	;,test
R10752	T35298	T35299	punct	**,0.01
R10753	T35299	T35291	ccomp	0.01,test
R10754	T35300	T35299	punct	;,0.01
R10755	T35301	T35299	nsubj	p,0.01
R10756	T35302	T35299	punct	<,0.01
R10757	T35303	T35291	punct	;,test
R10758	T35304	T35291	nmod	ANOVA,test
R10759	T35305	T35304	cc	and,ANOVA
R10760	T35306	T35307	compound	Tukey,HSD
R10761	T35307	T35304	conj	HSD,ANOVA
R10762	T35308	T35291	punct	),test
R10763	T35309	T35279	punct	.,indicate
R10764	T35311	T35312	compound	Scale,bars
R10765	T35312	T35313	nsubj	bars,are
R10766	T35314	T35315	nummod	50,μm
R10767	T35315	T35313	attr	μm,are
R10768	T35316	T35315	prep	in,μm
R10769	T35317	T35316	punct	(,in
R10770	T35318	T35316	pobj	A,in
R10771	T35319	T35315	punct	),μm
R10772	T35320	T35315	cc	and,μm
R10773	T35321	T35322	nummod	20,μm
R10774	T35322	T35315	conj	μm,μm
R10775	T35323	T35322	prep	in,μm
R10776	T35324	T35323	punct	(,in
R10777	T35325	T35323	pobj	B,in
R10778	T35326	T35313	punct	),are
R10779	T35327	T35313	punct	.,are
R10780	T36048	T36049	compound	E2f3,Loss
R10781	T36049	T36050	nsubj	Loss,Rescues
R10782	T36051	T36050	dobj	Differentiation,Rescues
R10783	T36052	T36051	prep	of,Differentiation
R10784	T36053	T36054	compound	Rb,KO
R10785	T36054	T36055	compound	KO,SACs
R10786	T36055	T36052	pobj	SACs,of
R10787	T36057	T36058	punct	(,A
R10788	T36058	T36059	meta	A,stained
R10789	T36060	T36058	punct	),A
R10790	T36061	T36062	amod	Horizontal,sections
R10791	T36062	T36059	nsubjpass	sections,stained
R10792	T36063	T36062	amod	retinal,sections
R10793	T36064	T36062	prep	of,sections
R10794	T36065	T36066	det	the,ages
R10795	T36066	T36064	pobj	ages,of
R10796	T36067	T36066	amod	indicated,ages
R10797	T36068	T36066	cc	and,ages
R10798	T36069	T36066	conj	genotypes,ages
R10799	T36070	T36059	auxpass	were,stained
R10800	T36071	T36059	prep	for,stained
R10801	T36072	T36071	pobj	nuclei,for
R10802	T36073	T36074	punct	(,blue
R10803	T36074	T36072	parataxis	blue,nuclei
R10804	T36075	T36074	dep	DAPI,blue
R10805	T36076	T36074	punct	", ",blue
R10806	T36077	T36074	punct	),blue
R10807	T36078	T36072	punct	", ",nuclei
R10808	T36079	T36080	compound	mitosis,marker
R10809	T36080	T36081	compound	marker,PH3
R10810	T36081	T36072	conj	PH3,nuclei
R10811	T36082	T36083	punct	(,green
R10812	T36083	T36081	parataxis	green,PH3
R10813	T36084	T36083	punct	),green
R10814	T36085	T36081	punct	", ",PH3
R10815	T36086	T36081	cc	and,PH3
R10816	T36087	T36081	conj	Slc18a3,PH3
R10817	T36088	T36089	punct	(,red
R10818	T36089	T36087	parataxis	red,Slc18a3
R10819	T36090	T36089	punct	),red
R10820	T36091	T36087	punct	", ",Slc18a3
R10821	T36092	T36093	dep	which,marks
R10822	T36093	T36087	relcl	marks,Slc18a3
R10823	T36094	T36095	compound	SAC,soma
R10824	T36095	T36093	dobj	soma,marks
R10825	T36096	T36093	prep	at,marks
R10826	T36097	T36098	amod	early,stages
R10827	T36098	T36096	pobj	stages,at
R10828	T36099	T36093	cc	and,marks
R10829	T36100	T36093	conj	processes,marks
R10830	T36101	T36100	prep	from,processes
R10831	T36102	T36103	punct	~,P5
R10832	T36103	T36101	pobj	P5,from
R10833	T36104	T36103	advmod	onwards,P5
R10834	T36105	T36059	punct	.,stained
R10835	T36107	T36108	nsubj	Arrows,show
R10836	T36109	T36110	amod	mitotic,nuclei
R10837	T36110	T36108	dobj	nuclei,show
R10838	T36111	T36110	nmod	PH3,nuclei
R10839	T36112	T36111	punct	+,PH3
R10840	T36113	T36108	prep	in,show
R10841	T36114	T36115	nmod	Rb,KO
R10842	T36115	T36116	nmod	KO,retinas
R10843	T36116	T36113	pobj	retinas,in
R10844	T36117	T36115	punct	", ",KO
R10845	T36118	T36119	compound	Rb,E2f2
R10846	T36119	T36121	compound	E2f2,DKO
R10847	T36120	T36119	punct	/,E2f2
R10848	T36121	T36115	conj	DKO,KO
R10849	T36122	T36121	punct	", ",DKO
R10850	T36123	T36121	cc	and,DKO
R10851	T36124	T36125	compound	Rb,E2f3
R10852	T36125	T36127	compound	E2f3,DKO
R10853	T36126	T36125	punct	/,E2f3
R10854	T36127	T36121	conj	DKO,DKO
R10855	T36128	T36108	punct	.,show
R10856	T36130	T36131	compound	E2f1,loss
R10857	T36131	T36132	nsubj	loss,rescues
R10858	T36133	T36134	det	the,defects
R10859	T36134	T36132	dobj	defects,rescues
R10860	T36135	T36136	amod	ectopic,mitosis
R10861	T36136	T36134	nmod	mitosis,defects
R10862	T36137	T36136	cc	and,mitosis
R10863	T36138	T36139	compound	cell,death
R10864	T36139	T36136	conj	death,mitosis
R10865	T36140	T36134	punct	", ",defects
R10866	T36141	T36134	cc	but,defects
R10867	T36142	T36141	neg	not,but
R10868	T36143	T36144	det	the,defect
R10869	T36144	T36134	conj	defect,defects
R10870	T36145	T36144	compound	SAC,defect
R10871	T36146	T36132	punct	.,rescues
R10872	T36148	T36149	compound	E2f2,loss
R10873	T36149	T36150	nsubj	loss,has
R10874	T36151	T36152	det	no,effect
R10875	T36152	T36150	dobj	effect,has
R10876	T36153	T36150	punct	.,has
R10877	T36155	T36156	compound	E2f3,loss
R10878	T36156	T36157	nsubj	loss,rescue
R10879	T36158	T36157	aux	does,rescue
R10880	T36159	T36157	neg	not,rescue
R10881	T36160	T36161	det	the,defects
R10882	T36161	T36157	dobj	defects,rescue
R10883	T36162	T36163	amod	ectopic,mitosis
R10884	T36163	T36161	nmod	mitosis,defects
R10885	T36164	T36163	cc	and,mitosis
R10886	T36165	T36166	compound	cell,loss
R10887	T36166	T36163	conj	loss,mitosis
R10888	T36167	T36157	punct	", ",rescue
R10889	T36168	T36157	cc	but,rescue
R10890	T36169	T36157	conj	rescues,rescue
R10891	T36170	T36171	det	the,defect
R10892	T36171	T36169	dobj	defect,rescues
R10893	T36172	T36171	compound	SAC,defect
R10894	T36173	T36157	punct	.,rescue
R10895	T36175	T36176	csubj	Inactivating,rescues
R10896	T36177	T36175	dobj	E2f1,Inactivating
R10897	T36178	T36177	cc	and,E2f1
R10898	T36179	T36177	conj	E2f3,E2f1
R10899	T36180	T36175	advmod	together,Inactivating
R10900	T36181	T36182	det	the,defects
R10901	T36182	T36176	dobj	defects,rescues
R10902	T36183	T36184	amod	ectopic,mitosis
R10903	T36184	T36182	nmod	mitosis,defects
R10904	T36185	T36184	punct	", ",mitosis
R10905	T36186	T36187	compound	cell,death
R10906	T36187	T36184	conj	death,mitosis
R10907	T36188	T36187	punct	", ",death
R10908	T36189	T36187	cc	and,death
R10909	T36190	T36187	conj	SAC,death
R10910	T36191	T36176	punct	.,rescues
R10911	T36193	T36194	punct	(,B
R10912	T36194	T36195	meta	B,fraction
R10913	T36196	T36194	punct	),B
R10914	T36197	T36195	det	The,fraction
R10915	T36198	T36195	prep	of,fraction
R10916	T36199	T36200	nmod	Camk2a,cells
R10917	T36200	T36198	pobj	cells,of
R10918	T36201	T36199	punct	+,Camk2a
R10919	T36202	T36203	dep	that,are
R10920	T36203	T36200	relcl	are,cells
R10921	T36204	T36203	attr	Chat,are
R10922	T36205	T36204	punct	+,Chat
R10923	T36206	T36204	cc	and,Chat
R10924	T36207	T36204	conj	Slc18a3,Chat
R10925	T36208	T36207	punct	+,Slc18a3
R10926	T36209	T36195	prep	in,fraction
R10927	T36210	T36211	det	the,retina
R10928	T36211	T36209	pobj	retina,in
R10929	T36212	T36211	compound	P30,retina
R10930	T36213	T36195	punct	.,fraction
R10931	T36215	T36216	punct	(,C
R10932	T36216	T36217	meta	C,stained
R10933	T36218	T36216	punct	),C
R10934	T36219	T36220	amod	Horizontal,sections
R10935	T36220	T36217	nsubjpass	sections,stained
R10936	T36221	T36220	compound	P5,sections
R10937	T36222	T36220	compound	retinal,sections
R10938	T36223	T36217	auxpass	were,stained
R10939	T36224	T36217	prep	for,stained
R10940	T36225	T36224	pobj	nuclei,for
R10941	T36226	T36227	punct	(,blue
R10942	T36227	T36225	parataxis	blue,nuclei
R10943	T36228	T36227	dep	DAPI,blue
R10944	T36229	T36227	punct	", ",blue
R10945	T36230	T36227	punct	),blue
R10946	T36231	T36225	punct	", ",nuclei
R10947	T36232	T36225	conj	Slc18a3,nuclei
R10948	T36233	T36234	punct	(,green
R10949	T36234	T36232	parataxis	green,Slc18a3
R10950	T36235	T36234	punct	),green
R10951	T36236	T36232	punct	", ",Slc18a3
R10952	T36237	T36232	cc	and,Slc18a3
R10953	T36238	T36232	conj	Isl1,Slc18a3
R10954	T36239	T36240	punct	(,red
R10955	T36240	T36238	parataxis	red,Isl1
R10956	T36241	T36240	punct	),red
R10957	T36242	T36217	punct	.,stained
R10958	T36244	T36245	nsubj	Arrows,show
R10959	T36246	T36247	amod	double,labelled
R10960	T36247	T36249	amod	labelled,cells
R10961	T36248	T36247	punct	-,labelled
R10962	T36249	T36245	dobj	cells,show
R10963	T36250	T36249	nmod	Isl1,cells
R10964	T36251	T36250	punct	+,Isl1
R10965	T36252	T36250	punct	/,Isl1
R10966	T36253	T36250	appos	Slc18a3,Isl1
R10967	T36254	T36253	punct	+,Slc18a3
R10968	T36255	T36245	prep	in,show
R10969	T36256	T36257	det	the,INL
R10970	T36257	T36255	pobj	INL,in
R10971	T36258	T36257	amod	inner,INL
R10972	T36259	T36245	punct	.,show
R10973	T36261	T36262	punct	(,D
R10974	T36262	T36263	meta	D,stained
R10975	T36264	T36262	punct	),D
R10976	T36265	T36266	amod	Horizontal,sections
R10977	T36266	T36263	nsubjpass	sections,stained
R10978	T36267	T36266	nmod	P0,sections
R10979	T36268	T36266	amod	retinal,sections
R10980	T36269	T36266	prep	of,sections
R10981	T36270	T36271	det	the,genotypes
R10982	T36271	T36269	pobj	genotypes,of
R10983	T36272	T36271	amod	indicated,genotypes
R10984	T36273	T36263	auxpass	were,stained
R10985	T36274	T36263	prep	for,stained
R10986	T36275	T36274	pobj	nuclei,for
R10987	T36276	T36277	punct	(,blue
R10988	T36277	T36275	parataxis	blue,nuclei
R10989	T36278	T36277	dep	DAPI,blue
R10990	T36279	T36277	punct	", ",blue
R10991	T36280	T36277	punct	),blue
R10992	T36281	T36275	punct	", ",nuclei
R10993	T36282	T36283	compound	cell,division
R10994	T36283	T36284	compound	division,marker
R10995	T36284	T36285	compound	marker,Mki67
R10996	T36285	T36275	conj	Mki67,nuclei
R10997	T36286	T36287	punct	(,green
R10998	T36287	T36285	parataxis	green,Mki67
R10999	T36288	T36287	punct	),green
R11000	T36289	T36285	punct	", ",Mki67
R11001	T36290	T36285	cc	and,Mki67
R11002	T36291	T36285	conj	Isl1,Mki67
R11003	T36292	T36293	punct	(,red
R11004	T36293	T36291	parataxis	red,Isl1
R11005	T36294	T36293	punct	),red
R11006	T36295	T36263	punct	.,stained
R11007	T36297	T36298	nsubj	Arrows,show
R11008	T36299	T36300	amod	double,labelled
R11009	T36300	T36302	amod	labelled,SACs
R11010	T36301	T36300	punct	-,labelled
R11011	T36302	T36298	dobj	SACs,show
R11012	T36303	T36302	amod	dividing,SACs
R11013	T36304	T36298	punct	.,show
R11014	T36306	T36307	punct	(,E
R11015	T36307	T36308	meta	E,fraction
R11016	T36309	T36307	punct	),E
R11017	T36310	T36308	det	The,fraction
R11018	T36311	T36308	prep	of,fraction
R11019	T36312	T36313	nmod	Isl1,cells
R11020	T36313	T36311	pobj	cells,of
R11021	T36314	T36312	punct	+,Isl1
R11022	T36315	T36313	prep	in,cells
R11023	T36316	T36317	det	the,NBL
R11024	T36317	T36315	pobj	NBL,in
R11025	T36318	T36317	amod	inner,NBL
R11026	T36319	T36317	punct	(,NBL
R11027	T36320	T36317	appos	INBL,NBL
R11028	T36321	T36317	punct	),NBL
R11029	T36322	T36317	prep	of,NBL
R11030	T36323	T36324	compound	P0,retinas
R11031	T36324	T36322	pobj	retinas,of
R11032	T36325	T36326	dep	that,dividing
R11033	T36326	T36313	relcl	dividing,cells
R11034	T36327	T36326	aux	are,dividing
R11035	T36328	T36329	punct	(,Mki67
R11036	T36329	T36326	parataxis	Mki67,dividing
R11037	T36330	T36329	punct	+,Mki67
R11038	T36331	T36329	punct	),Mki67
R11039	T36332	T36308	punct	.,fraction
R11040	T36334	T36335	compound	Error,bars
R11041	T36335	T36336	nsubj	bars,represent
R11042	T36337	T36336	dobj	SD,represent
R11043	T36338	T36337	prep	of,SD
R11044	T36339	T36338	pobj	measurements,of
R11045	T36340	T36339	prep	from,measurements
R11046	T36341	T36342	nummod	three,animals
R11047	T36342	T36340	pobj	animals,from
R11048	T36343	T36336	punct	", ",represent
R11049	T36344	T36336	cc	and,represent
R11050	T36345	T36346	nsubj	asterisks,indicate
R11051	T36346	T36336	conj	indicate,represent
R11052	T36347	T36348	amod	significant,differences
R11053	T36348	T36346	dobj	differences,indicate
R11054	T36349	T36348	prep	between,differences
R11055	T36350	T36349	pobj	retinas,between
R11056	T36351	T36350	prep	of,retinas
R11057	T36352	T36351	pobj	WT,of
R11058	T36353	T36352	cc	and,WT
R11059	T36354	T36355	det	the,indicated
R11060	T36355	T36356	nmod	indicated,genotypes
R11061	T36356	T36352	conj	genotypes,WT
R11062	T36357	T36358	punct	(,test
R11063	T36358	T36346	parataxis	test,indicate
R11064	T36359	T36360	punct	*,0.05
R11065	T36360	T36358	ccomp	0.05,test
R11066	T36361	T36360	punct	", ",0.05
R11067	T36362	T36360	nsubj	p,0.05
R11068	T36363	T36360	punct	<,0.05
R11069	T36364	T36358	punct	;,test
R11070	T36365	T36366	punct	**,0.01
R11071	T36366	T36358	ccomp	0.01,test
R11072	T36367	T36366	punct	;,0.01
R11073	T36368	T36366	nsubj	p,0.01
R11074	T36369	T36366	punct	<,0.01
R11075	T36370	T36358	punct	;,test
R11076	T36371	T36358	nmod	ANOVA,test
R11077	T36372	T36371	cc	and,ANOVA
R11078	T36373	T36374	compound	Tukey,HSD
R11079	T36374	T36371	conj	HSD,ANOVA
R11080	T36375	T36358	punct	),test
R11081	T36376	T36346	punct	.,indicate
R11082	T36378	T36379	compound	Scale,bars
R11083	T36379	T36380	nsubj	bars,are
R11084	T36381	T36379	prep	in,bars
R11085	T36382	T36381	punct	(,in
R11086	T36383	T36381	pobj	A,in
R11087	T36384	T36383	punct	),A
R11088	T36385	T36383	punct	", ",A
R11089	T36386	T36387	punct	(,C
R11090	T36387	T36383	conj	C,A
R11091	T36388	T36387	punct	),C
R11092	T36389	T36387	punct	", ",C
R11093	T36390	T36387	cc	and,C
R11094	T36391	T36392	punct	(,D
R11095	T36392	T36387	conj	D,C
R11096	T36393	T36380	punct	),are
R11097	T36394	T36395	nummod	50,μm
R11098	T36395	T36380	attr	μm,are
R11099	T36396	T36380	punct	.,are
R11106	T36780	T36781	nmod	E2f3,Expression
R11107	T36782	T36780	cc	and,E2f3
R11108	T36783	T36780	conj	Rb,E2f3
R11109	T36784	T36781	prep	in,Expression
R11110	T36785	T36784	pobj	SACs,in
R11111	T36787	T36788	punct	(,A
R11112	T36788	T36789	meta	A,stained
R11113	T36790	T36788	punct	),A
R11114	T36791	T36792	amod	Left,panels
R11115	T36792	T36789	dep	panels,stained
R11116	T36793	T36789	punct	: ,stained
R11117	T36794	T36795	amod	horizontal,sections
R11118	T36795	T36789	nsubjpass	sections,stained
R11119	T36796	T36795	nmod	P0,sections
R11120	T36797	T36796	punct	", ",P0
R11121	T36798	T36796	conj	P8,P0
R11122	T36799	T36798	punct	", ",P8
R11123	T36800	T36798	cc	and,P8
R11124	T36801	T36798	conj	P18,P8
R11125	T36802	T36795	amod	retinal,sections
R11126	T36803	T36795	prep	of,sections
R11127	T36804	T36805	det	the,genotypes
R11128	T36805	T36803	pobj	genotypes,of
R11129	T36806	T36805	amod	indicated,genotypes
R11130	T36807	T36789	auxpass	were,stained
R11131	T36808	T36789	prep	for,stained
R11132	T36809	T36808	pobj	E2f3,for
R11133	T36810	T36811	punct	(,red
R11134	T36811	T36809	parataxis	red,E2f3
R11135	T36812	T36811	punct	),red
R11136	T36813	T36809	cc	and,E2f3
R11137	T36814	T36809	conj	DAPI,E2f3
R11138	T36815	T36816	punct	(,blue
R11139	T36816	T36814	parataxis	blue,DAPI
R11140	T36817	T36816	punct	),blue
R11141	T36818	T36789	punct	.,stained
R11142	T36820	T36821	det	The,arrow
R11143	T36821	T36822	nsubj	arrow,indicates
R11144	T36823	T36824	det	the,junction
R11145	T36824	T36822	dobj	junction,indicates
R11146	T36825	T36824	prep	between,junction
R11147	T36826	T36827	det	the,peripheral
R11148	T36827	T36825	pobj	peripheral,between
R11149	T36828	T36829	npadvmod	E2f3,null
R11150	T36829	T36827	amod	null,peripheral
R11151	T36830	T36827	cc	and,peripheral
R11152	T36831	T36832	nmod	WT,retina
R11153	T36832	T36827	conj	retina,peripheral
R11154	T36833	T36831	amod	central,WT
R11155	T36834	T36832	compound	P0,retina
R11156	T36835	T36822	punct	.,indicates
R11157	T36838	T36839	det	the,absence
R11158	T36839	T36837	dobj	absence,Note
R11159	T36840	T36839	prep	of,absence
R11160	T36841	T36842	compound	E2f3,protein
R11161	T36842	T36840	pobj	protein,of
R11162	T36843	T36839	prep	in,absence
R11163	T36844	T36845	det	the,RPCs
R11164	T36845	T36843	pobj	RPCs,in
R11165	T36846	T36845	amod	peripheral,RPCs
R11166	T36847	T36848	compound	E2f3,KO
R11167	T36848	T36845	compound	KO,RPCs
R11168	T36849	T36839	prep	at,absence
R11169	T36850	T36849	pobj	P0,at
R11170	T36851	T36839	cc	and,absence
R11171	T36852	T36853	prep	in,at
R11172	T36853	T36839	conj	at,absence
R11173	T36854	T36855	amod	peripheral,neurons
R11174	T36855	T36852	pobj	neurons,in
R11175	T36856	T36855	amod	inner,neurons
R11176	T36857	T36855	amod	retinal,neurons
R11177	T36858	T36853	pobj	P18,at
R11178	T36859	T36837	punct	.,Note
R11179	T36861	T36862	advmod	Far,right
R11180	T36862	T36863	amod	right,panel
R11181	T36863	T36864	dep	panel,stained
R11182	T36865	T36864	punct	: ,stained
R11183	T36866	T36867	nmod	P18,sections
R11184	T36867	T36864	nsubjpass	sections,stained
R11185	T36868	T36867	amod	retinal,sections
R11186	T36869	T36867	prep	of,sections
R11187	T36870	T36871	det	the,genotypes
R11188	T36871	T36869	pobj	genotypes,of
R11189	T36872	T36871	amod	indicated,genotypes
R11190	T36873	T36864	auxpass	were,stained
R11191	T36874	T36864	prep	for,stained
R11192	T36875	T36874	pobj	Rb,for
R11193	T36876	T36877	punct	(,red
R11194	T36877	T36875	parataxis	red,Rb
R11195	T36878	T36877	punct	),red
R11196	T36879	T36875	cc	and,Rb
R11197	T36880	T36875	conj	DAPI,Rb
R11198	T36881	T36882	punct	(,blue
R11199	T36882	T36880	parataxis	blue,DAPI
R11200	T36883	T36882	punct	),blue
R11201	T36884	T36864	punct	.,stained
R11202	T36887	T36888	det	the,absence
R11203	T36888	T36886	dobj	absence,Note
R11204	T36889	T36888	prep	of,absence
R11205	T36890	T36891	compound	Rb,protein
R11206	T36891	T36889	pobj	protein,of
R11207	T36892	T36888	prep	in,absence
R11208	T36893	T36894	det	the,neurons
R11209	T36894	T36892	pobj	neurons,in
R11210	T36895	T36894	amod	peripheral,neurons
R11211	T36896	T36897	nmod	Rb,KO
R11212	T36897	T36894	nmod	KO,neurons
R11213	T36898	T36894	amod	inner,neurons
R11214	T36899	T36894	amod	retinal,neurons
R11215	T36900	T36886	punct	.,Note
R11216	T36902	T36903	punct	(,B
R11217	T36903	T36904	meta	B,stained
R11218	T36905	T36903	punct	),B
R11219	T36906	T36907	nmod	WT,sections
R11220	T36907	T36904	nsubjpass	sections,stained
R11221	T36908	T36907	nmod	P18,sections
R11222	T36909	T36907	amod	retinal,sections
R11223	T36910	T36904	auxpass	were,stained
R11224	T36911	T36904	prep	for,stained
R11225	T36912	T36911	pobj	nuclei,for
R11226	T36913	T36914	punct	(,blue
R11227	T36914	T36912	parataxis	blue,nuclei
R11228	T36915	T36914	dep	DAPI,blue
R11229	T36916	T36914	punct	", ",blue
R11230	T36917	T36914	punct	),blue
R11231	T36918	T36912	punct	", ",nuclei
R11232	T36919	T36912	conj	E2f3,nuclei
R11233	T36920	T36921	punct	(,red
R11234	T36921	T36919	parataxis	red,E2f3
R11235	T36922	T36921	punct	),red
R11236	T36923	T36919	cc	or,E2f3
R11237	T36924	T36919	conj	Rb,E2f3
R11238	T36925	T36926	punct	(,red
R11239	T36926	T36924	parataxis	red,Rb
R11240	T36927	T36926	punct	),red
R11241	T36928	T36924	punct	", ",Rb
R11242	T36929	T36924	cc	and,Rb
R11243	T36930	T36924	conj	Chat,Rb
R11244	T36931	T36930	cc	plus,Chat
R11245	T36932	T36930	conj	Slc18a3,Chat
R11246	T36933	T36934	punct	(,green
R11247	T36934	T36932	parataxis	green,Slc18a3
R11248	T36935	T36934	punct	),green
R11249	T36936	T36904	punct	.,stained
R11250	T36938	T36939	nsubj	Arrows,indicate
R11251	T36940	T36941	amod	double,labelled
R11252	T36941	T36943	amod	labelled,soma
R11253	T36942	T36941	punct	-,labelled
R11254	T36943	T36939	dobj	soma,indicate
R11255	T36944	T36939	punct	.,indicate
R11256	T36947	T36948	mark	that,labelled
R11257	T36948	T36946	ccomp	labelled,Note
R11258	T36949	T36950	det	the,processes
R11259	T36950	T36948	nsubjpass	processes,labelled
R11260	T36951	T36950	compound	IPL,processes
R11261	T36952	T36948	auxpass	are,labelled
R11262	T36953	T36948	advmod	also,labelled
R11263	T36954	T36948	amod	double,labelled
R11264	T36955	T36948	punct	-,labelled
R11265	T36956	T36946	punct	.,Note
R11266	T36958	T36959	compound	Scale,bars
R11267	T36959	T36960	nsubj	bars,are
R11268	T36961	T36962	nummod	50,μm
R11269	T36962	T36960	attr	μm,are
R11270	T36963	T36960	punct	.,are
R11271	T37145	T37146	amod	Subcellular,Distribution
R11272	T37147	T37146	prep	of,Distribution
R11273	T37148	T37149	compound	E2f3,Isoforms
R11274	T37149	T37147	pobj	Isoforms,of
R11275	T37150	T37149	cc	and,Isoforms
R11276	T37151	T37152	amod	Other,Proteins
R11277	T37152	T37149	conj	Proteins,Isoforms
R11278	T37153	T37154	compound	Cell,Cycle
R11279	T37154	T37152	compound	Cycle,Proteins
R11280	T37155	T37146	prep	in,Distribution
R11281	T37156	T37157	det	the,Retina
R11282	T37157	T37155	pobj	Retina,in
R11283	T37158	T37157	amod	Developing,Retina
R11284	T37160	T37161	amod	Nuclear,extracts
R11285	T37161	T37164	nsubjpass	extracts,analyzed
R11286	T37162	T37160	cc	and,Nuclear
R11287	T37163	T37160	conj	cytoplasmic,Nuclear
R11288	T37165	T37161	prep	from,extracts
R11289	T37166	T37167	det	an,number
R11290	T37167	T37165	pobj	number,from
R11291	T37168	T37167	amod	equivalent,number
R11292	T37169	T37167	prep	of,number
R11293	T37170	T37171	amod	retinal,cells
R11294	T37171	T37169	pobj	cells,of
R11295	T37172	T37171	prep	from,cells
R11296	T37173	T37172	pobj	mice,from
R11297	T37174	T37173	prep	of,mice
R11298	T37175	T37176	det	the,genotypes
R11299	T37176	T37174	pobj	genotypes,of
R11300	T37177	T37176	amod	indicated,genotypes
R11301	T37178	T37176	cc	and,genotypes
R11302	T37179	T37176	conj	ages,genotypes
R11303	T37180	T37164	auxpass	were,analyzed
R11304	T37181	T37164	prep	by,analyzed
R11305	T37182	T37183	compound	Western,blotting
R11306	T37183	T37181	pobj	blotting,by
R11307	T37184	T37185	aux	to,detect
R11308	T37185	T37164	advcl	detect,analyzed
R11309	T37186	T37187	det	the,proteins
R11310	T37187	T37185	dobj	proteins,detect
R11311	T37188	T37187	amod	indicated,proteins
R11312	T37189	T37164	punct	.,analyzed
R11313	T37191	T37192	nsubjpass	Lysate,used
R11314	T37193	T37191	prep	from,Lysate
R11315	T37194	T37195	nmod	E2f3a,mice
R11316	T37195	T37193	pobj	mice,from
R11317	T37196	T37194	punct	−,E2f3a
R11318	T37197	T37194	punct	/,E2f3a
R11319	T37198	T37194	punct	−,E2f3a
R11320	T37199	T37192	auxpass	was,used
R11321	T37200	T37192	prep	as,used
R11322	T37201	T37202	det	a,control
R11323	T37202	T37200	pobj	control,as
R11324	T37203	T37204	aux	to,confirm
R11325	T37204	T37192	advcl	confirm,used
R11326	T37205	T37206	det	the,location
R11327	T37206	T37204	dobj	location,confirm
R11328	T37207	T37206	prep	of,location
R11329	T37208	T37209	compound	E2f3a,protein
R11330	T37209	T37207	pobj	protein,of
R11331	T37210	T37192	punct	.,used
R11332	T37213	T37212	punct	", ",C
R11333	T37214	T37215	amod	cytoplasmic,extracts
R11334	T37215	T37212	appos	extracts,C
R11335	T37216	T37212	punct	;,C
R11336	T37217	T37212	appos	N,C
R11337	T37218	T37217	punct	", ",N
R11338	T37219	T37220	amod	nuclear,extracts
R11339	T37220	T37217	appos	extracts,N
R11340	T37221	T37212	punct	.,C
R11341	T37915	T37916	det	The,Isoform
R11342	T37916	T37918	nsubj	Isoform,Drives
R11343	T37917	T37916	compound	E2f3a,Isoform
R11344	T37919	T37920	det	the,Defect
R11345	T37920	T37918	dobj	Defect,Drives
R11346	T37921	T37920	compound	Differentiation,Defect
R11347	T37922	T37918	prep	in,Drives
R11348	T37923	T37924	compound	Rb,KO
R11349	T37924	T37925	compound	KO,SACs
R11350	T37925	T37922	pobj	SACs,in
R11351	T37927	T37928	punct	(,A
R11352	T37928	T37929	meta	A,diagrams
R11353	T37930	T37928	punct	),A
R11354	T37931	T37929	amod	Schematic,diagrams
R11355	T37932	T37929	prep	of,diagrams
R11356	T37933	T37934	det	the,WT
R11357	T37934	T37932	pobj	WT,of
R11358	T37935	T37934	compound	mouse,WT
R11359	T37936	T37934	punct	", ",WT
R11360	T37937	T37934	conj	E2f3a,WT
R11361	T37938	T37937	punct	−,E2f3a
R11362	T37939	T37937	punct	/,E2f3a
R11363	T37940	T37937	punct	−,E2f3a
R11364	T37941	T37937	punct	", ",E2f3a
R11365	T37942	T37937	cc	and,E2f3a
R11366	T37943	T37944	det	the,loci
R11367	T37944	T37937	conj	loci,E2f3a
R11368	T37945	T37944	nmod	Cre,loci
R11369	T37946	T37945	punct	-,Cre
R11370	T37947	T37945	amod	recombined,Cre
R11371	T37948	T37944	amod	floxed,loci
R11372	T37949	T37944	compound	E2f3,loci
R11373	T37950	T37944	punct	(,loci
R11374	T37951	T37944	acl	indicated,loci
R11375	T37952	T37951	advmod	here,indicated
R11376	T37953	T37951	prep	as,indicated
R11377	T37954	T37953	pobj	E2f3,as
R11378	T37955	T37954	punct	−,E2f3
R11379	T37956	T37954	punct	/,E2f3
R11380	T37957	T37954	punct	−,E2f3
R11381	T37958	T37951	prep	for,indicated
R11382	T37959	T37958	pobj	simplicity,for
R11383	T37960	T37929	punct	),diagrams
R11384	T37961	T37929	punct	.,diagrams
R11385	T37963	T37964	nmod	E2f3a,mice
R11386	T37964	T37968	nsubj	mice,lack
R11387	T37965	T37963	punct	−,E2f3a
R11388	T37966	T37963	punct	/,E2f3a
R11389	T37967	T37963	punct	−,E2f3a
R11390	T37969	T37968	dobj	most,lack
R11391	T37970	T37969	prep	of,most
R11392	T37971	T37972	compound	E2f3,1a
R11393	T37972	T37970	pobj	1a,of
R11394	T37973	T37972	compound	exon,1a
R11395	T37974	T37969	cc	and,most
R11396	T37975	T37969	conj	part,most
R11397	T37976	T37975	prep	of,part
R11398	T37977	T37978	compound	intron,1a
R11399	T37978	T37976	pobj	1a,of
R11400	T37979	T37980	punct	(,box
R11401	T37980	T37968	parataxis	box,lack
R11402	T37981	T37980	amod	red,box
R11403	T37982	T37980	amod	dotted,box
R11404	T37983	T37980	punct	),box
R11405	T37984	T37968	punct	.,lack
R11406	T37986	T37987	nsubj	Arrows,indicate
R11407	T37988	T37989	compound	PCR,primers
R11408	T37989	T37987	dobj	primers,indicate
R11409	T37990	T37987	punct	.,indicate
R11410	T37992	T37993	nsubjpass	Genotyping,shown
R11411	T37994	T37992	prep	of,Genotyping
R11412	T37995	T37996	det	an,mouse
R11413	T37996	T37994	pobj	mouse,of
R11414	T37997	T37996	nmod	E2f3a,mouse
R11415	T37998	T37997	punct	+,E2f3a
R11416	T37999	T37997	punct	/,E2f3a
R11417	T38000	T37997	punct	−,E2f3a
R11418	T38001	T37993	auxpass	is,shown
R11419	T38002	T37993	prep	on,shown
R11420	T38003	T38004	det	the,right
R11421	T38004	T38002	pobj	right,on
R11422	T38005	T37993	punct	.,shown
R11423	T38007	T38008	punct	(,B
R11424	T38008	T38009	meta	B,detection
R11425	T38010	T38008	punct	),B
R11426	T38011	T38012	compound	RT,PCR
R11427	T38012	T38009	compound	PCR,detection
R11428	T38013	T38012	punct	-,PCR
R11429	T38014	T38009	prep	of,detection
R11430	T38015	T38016	nmod	E2f3a,mRNA
R11431	T38016	T38014	pobj	mRNA,of
R11432	T38017	T38015	cc	and,E2f3a
R11433	T38018	T38015	conj	E2f3b,E2f3a
R11434	T38019	T38009	prep	in,detection
R11435	T38020	T38021	det	the,retina
R11436	T38021	T38019	pobj	retina,in
R11437	T38022	T38009	punct	.,detection
R11438	T38024	T38025	det	The,sequences
R11439	T38025	T38026	nsubj	sequences,are
R11440	T38027	T38025	prep	of,sequences
R11441	T38028	T38027	pobj	primers,of
R11442	T38029	T38026	attr	1aF,are
R11443	T38030	T38029	punct	(,1aF
R11444	T38031	T38032	nummod	5,GCCTCTACACCACGCCACAAG
R11445	T38032	T38029	appos	GCCTCTACACCACGCCACAAG,1aF
R11446	T38033	T38031	punct	′,5
R11447	T38034	T38032	punct	-,GCCTCTACACCACGCCACAAG
R11448	T38035	T38032	punct	-,GCCTCTACACCACGCCACAAG
R11449	T38036	T38032	nummod	3,GCCTCTACACCACGCCACAAG
R11450	T38037	T38032	punct	′,GCCTCTACACCACGCCACAAG
R11451	T38038	T38029	punct	),1aF
R11452	T38039	T38029	punct	", ",1aF
R11453	T38040	T38029	conj	1bF,1aF
R11454	T38041	T38040	punct	(,1bF
R11455	T38042	T38043	nummod	5,CGGAAATGCCCTTACAGC
R11456	T38043	T38040	appos	CGGAAATGCCCTTACAGC,1bF
R11457	T38044	T38042	punct	′,5
R11458	T38045	T38043	punct	-,CGGAAATGCCCTTACAGC
R11459	T38046	T38043	punct	-,CGGAAATGCCCTTACAGC
R11460	T38047	T38043	nummod	3,CGGAAATGCCCTTACAGC
R11461	T38048	T38043	punct	′,CGGAAATGCCCTTACAGC
R11462	T38049	T38040	punct	),1bF
R11463	T38050	T38040	punct	", ",1bF
R11464	T38051	T38040	cc	and,1bF
R11465	T38052	T38040	conj	4R,1bF
R11466	T38053	T38052	punct	(,4R
R11467	T38054	T38055	nummod	5,CTCAGTCACTTCTTTGGACAG
R11468	T38055	T38052	appos	CTCAGTCACTTCTTTGGACAG,4R
R11469	T38056	T38054	punct	′,5
R11470	T38057	T38055	punct	-,CTCAGTCACTTCTTTGGACAG
R11471	T38058	T38055	punct	-,CTCAGTCACTTCTTTGGACAG
R11472	T38059	T38055	nummod	3,CTCAGTCACTTCTTTGGACAG
R11473	T38060	T38055	punct	′,CTCAGTCACTTCTTTGGACAG
R11474	T38061	T38026	punct	),are
R11475	T38062	T38026	punct	.,are
R11476	T38064	T38065	compound	WT,retina
R11477	T38065	T38066	nsubj	retina,expresses
R11478	T38067	T38068	preconj	both,E2f3a
R11479	T38068	T38069	nmod	E2f3a,mRNA
R11480	T38069	T38066	dobj	mRNA,expresses
R11481	T38070	T38068	cc	and,E2f3a
R11482	T38071	T38068	conj	E2f3b,E2f3a
R11483	T38072	T38066	punct	.,expresses
R11484	T38074	T38075	mark	As,expected
R11485	T38075	T38076	advcl	expected,lacks
R11486	T38077	T38076	punct	", ",lacks
R11487	T38078	T38079	nmod	E2f3a,retina
R11488	T38079	T38076	nsubj	retina,lacks
R11489	T38080	T38078	punct	−,E2f3a
R11490	T38081	T38078	punct	/,E2f3a
R11491	T38082	T38078	punct	−,E2f3a
R11492	T38083	T38084	compound	E2f3a,mRNA
R11493	T38084	T38076	dobj	mRNA,lacks
R11494	T38085	T38076	cc	and,lacks
R11495	T38086	T38087	advmod	still,expresses
R11496	T38087	T38076	conj	expresses,lacks
R11497	T38088	T38089	compound	E2f3b,mRNA
R11498	T38089	T38087	dobj	mRNA,expresses
R11499	T38090	T38076	punct	.,lacks
R11500	T38092	T38093	nmod	E2f3,retina
R11501	T38093	T38097	nsubj	retina,lacks
R11502	T38094	T38092	punct	−,E2f3
R11503	T38095	T38092	punct	/,E2f3
R11504	T38096	T38092	punct	−,E2f3
R11505	T38098	T38099	amod	full,length
R11506	T38099	T38101	nmod	length,mRNAs
R11507	T38100	T38099	punct	-,length
R11508	T38101	T38097	dobj	mRNAs,lacks
R11509	T38102	T38101	nmod	E2f3a,mRNAs
R11510	T38103	T38102	cc	and,E2f3a
R11511	T38104	T38102	conj	E2f3b,E2f3a
R11512	T38105	T38097	punct	", ",lacks
R11513	T38106	T38097	cc	and,lacks
R11514	T38107	T38108	advmod	instead,expresses
R11515	T38108	T38097	conj	expresses,lacks
R11516	T38109	T38110	det	a,mRNA
R11517	T38110	T38108	dobj	mRNA,expresses
R11518	T38111	T38110	amod	truncated,mRNA
R11519	T38112	T38110	acl	lacking,mRNA
R11520	T38113	T38112	dobj	exon,lacking
R11521	T38114	T38113	nummod	3,exon
R11522	T38115	T38097	punct	.,lacks
R11523	T38117	T38118	punct	(,C
R11524	T38118	T38119	meta	C,analysis
R11525	T38120	T38118	punct	),C
R11526	T38121	T38122	amod	Real,time
R11527	T38122	T38119	compound	time,analysis
R11528	T38123	T38122	punct	-,time
R11529	T38124	T38125	compound	RT,PCR
R11530	T38125	T38119	compound	PCR,analysis
R11531	T38126	T38125	punct	-,PCR
R11532	T38127	T38119	prep	of,analysis
R11533	T38128	T38129	compound	E2f,genes
R11534	T38129	T38127	pobj	genes,of
R11535	T38130	T38119	prep	in,analysis
R11536	T38131	T38132	compound	P8,retinas
R11537	T38132	T38130	pobj	retinas,in
R11538	T38133	T38132	prep	of,retinas
R11539	T38134	T38135	det	the,genotypes
R11540	T38135	T38133	pobj	genotypes,of
R11541	T38136	T38135	amod	indicated,genotypes
R11542	T38137	T38119	punct	.,analysis
R11543	T38139	T38140	compound	Error,bars
R11544	T38140	T38141	nsubj	bars,represent
R11545	T38142	T38141	dobj	SD,represent
R11546	T38143	T38142	prep	of,SD
R11547	T38144	T38143	pobj	measurements,of
R11548	T38145	T38144	prep	from,measurements
R11549	T38146	T38147	nummod	three,animals
R11550	T38147	T38145	pobj	animals,from
R11551	T38148	T38141	punct	", ",represent
R11552	T38149	T38141	cc	and,represent
R11553	T38150	T38151	nsubj	asterisks,indicate
R11554	T38151	T38141	conj	indicate,represent
R11555	T38152	T38153	det	a,difference
R11556	T38153	T38151	dobj	difference,indicate
R11557	T38154	T38153	amod	significant,difference
R11558	T38155	T38153	prep	between,difference
R11559	T38156	T38155	pobj	WT,between
R11560	T38157	T38156	cc	and,WT
R11561	T38158	T38159	det	the,indicated
R11562	T38159	T38160	nmod	indicated,genotypes
R11563	T38160	T38156	conj	genotypes,WT
R11564	T38161	T38162	punct	(,test
R11565	T38162	T38153	parataxis	test,difference
R11566	T38163	T38164	punct	*,0.05
R11567	T38164	T38162	ccomp	0.05,test
R11568	T38165	T38164	punct	", ",0.05
R11569	T38166	T38164	nsubj	p,0.05
R11570	T38167	T38164	punct	<,0.05
R11571	T38168	T38162	punct	;,test
R11572	T38169	T38170	punct	**,0.01
R11573	T38170	T38162	ccomp	0.01,test
R11574	T38171	T38170	punct	;,0.01
R11575	T38172	T38170	nsubj	p,0.01
R11576	T38173	T38170	punct	<,0.01
R11577	T38174	T38162	punct	;,test
R11578	T38175	T38162	nmod	ANOVA,test
R11579	T38176	T38175	cc	and,ANOVA
R11580	T38177	T38178	compound	Tukey,HSD
R11581	T38178	T38175	conj	HSD,ANOVA
R11582	T38179	T38162	punct	),test
R11583	T38180	T38151	punct	.,indicate
R11584	T38182	T38183	punct	(,D
R11585	T38183	T38184	meta	D,Rescue
R11586	T38185	T38183	punct	),D
R11587	T38186	T38184	prep	of,Rescue
R11588	T38187	T38188	compound	Rb,KO
R11589	T38188	T38189	compound	KO,SACs
R11590	T38189	T38186	pobj	SACs,of
R11591	T38190	T38184	prep	by,Rescue
R11592	T38191	T38192	compound	E2f3a,deletion
R11593	T38192	T38190	pobj	deletion,by
R11594	T38193	T38184	punct	.,Rescue
R11595	T38195	T38196	amod	Horizontal,sections
R11596	T38196	T38198	nsubjpass	sections,stained
R11597	T38197	T38196	amod	retinal,sections
R11598	T38199	T38196	prep	of,sections
R11599	T38200	T38201	det	the,genotypes
R11600	T38201	T38199	pobj	genotypes,of
R11601	T38202	T38201	amod	indicated,genotypes
R11602	T38203	T38201	cc	and,genotypes
R11603	T38204	T38201	conj	ages,genotypes
R11604	T38205	T38198	auxpass	were,stained
R11605	T38206	T38198	prep	for,stained
R11606	T38207	T38206	pobj	nuclei,for
R11607	T38208	T38209	punct	(,blue
R11608	T38209	T38207	parataxis	blue,nuclei
R11609	T38210	T38209	dep	DAPI,blue
R11610	T38211	T38209	punct	", ",blue
R11611	T38212	T38209	punct	),blue
R11612	T38213	T38207	punct	", ",nuclei
R11613	T38214	T38215	compound	M,phase
R11614	T38215	T38207	conj	phase,nuclei
R11615	T38216	T38215	punct	-,phase
R11616	T38217	T38218	punct	(,green
R11617	T38218	T38215	parataxis	green,phase
R11618	T38219	T38218	dep	PH3,green
R11619	T38220	T38218	punct	", ",green
R11620	T38221	T38218	punct	),green
R11621	T38222	T38215	punct	", ",phase
R11622	T38223	T38215	cc	and,phase
R11623	T38224	T38225	det	the,marker
R11624	T38225	T38215	conj	marker,phase
R11625	T38226	T38225	compound	SAC,marker
R11626	T38227	T38225	appos	Slc18a3,marker
R11627	T38228	T38229	punct	(,red
R11628	T38229	T38225	parataxis	red,marker
R11629	T38230	T38229	punct	),red
R11630	T38231	T38198	punct	.,stained
R11631	T38233	T38234	compound	E2f3a,deletion
R11632	T38234	T38235	nsubj	deletion,suppress
R11633	T38236	T38235	aux	does,suppress
R11634	T38237	T38235	neg	not,suppress
R11635	T38238	T38239	amod	ectopic,division
R11636	T38239	T38235	dobj	division,suppress
R11637	T38240	T38235	punct	", ",suppress
R11638	T38241	T38235	cc	but,suppress
R11639	T38242	T38235	conj	rescues,suppress
R11640	T38243	T38244	det	the,defect
R11641	T38244	T38242	dobj	defect,rescues
R11642	T38245	T38244	compound	SAC,defect
R11643	T38246	T38235	punct	.,suppress
R11644	T38248	T38249	compound	Scale,bars
R11645	T38249	T38250	nsubj	bars,are
R11646	T38251	T38252	nummod	50,μm
R11647	T38252	T38250	attr	μm,are
R11648	T38253	T38250	punct	.,are
R11649	T38256	T38255	punct	", ",M
R11650	T38257	T38258	amod	molecular,size
R11651	T38258	T38259	compound	size,marker
R11652	T38259	T38255	appos	marker,M
R11653	T38260	T38255	punct	.,M
R11654	T38541	T38542	nsubj	Rb,Regulates
R11655	T38543	T38544	amod	Distinct,Processes
R11656	T38544	T38542	dobj	Processes,Regulates
R11657	T38545	T38542	prep	through,Regulates
R11658	T38546	T38545	pobj	E2f1,through
R11659	T38547	T38546	cc	and,E2f1
R11660	T38548	T38546	conj	E2f3a,E2f1
R11661	T38550	T38551	amod	Red,text
R11662	T38551	T38552	nsubj	text,indicate
R11663	T38553	T38551	cc	and,text
R11664	T38554	T38551	conj	arrows,text
R11665	T38555	T38556	npadvmod	Rb,dependent
R11666	T38556	T38558	amod	dependent,events
R11667	T38557	T38556	punct	-,dependent
R11668	T38558	T38552	dobj	events,indicate
R11669	T38559	T38552	punct	.,indicate
R11670	T38561	T38562	amod	Black,text
R11671	T38562	T38563	nsubj	text,indicate
R11672	T38564	T38562	cc	and,text
R11673	T38565	T38562	conj	arrows,text
R11674	T38566	T38563	dobj	events,indicate
R11675	T38567	T38568	prep	for,is
R11676	T38568	T38566	relcl	is,events
R11677	T38569	T38567	pobj	which,for
R11678	T38570	T38568	expl	there,is
R11679	T38571	T38572	det	no,evidence
R11680	T38572	T38568	attr	evidence,is
R11681	T38573	T38572	amod	direct,evidence
R11682	T38574	T38572	prep	of,evidence
R11683	T38575	T38576	compound	Rb,involvement
R11684	T38576	T38574	pobj	involvement,of
R11685	T38577	T38563	punct	.,indicate
R11686	T38579	T38580	nsubj	Rb,appear
R11687	T38581	T38580	aux	does,appear
R11688	T38582	T38580	neg	not,appear
R11689	T38583	T38584	aux	to,temper
R11690	T38584	T38580	xcomp	temper,appear
R11691	T38585	T38586	compound	RPC,expansion
R11692	T38586	T38584	dobj	expansion,temper
R11693	T38587	T38580	cc	and,appear
R11694	T38588	T38589	auxpass	is,required
R11695	T38589	T38580	conj	required,appear
R11696	T38590	T38589	neg	not,required
R11697	T38591	T38589	prep	for,required
R11698	T38592	T38591	pobj	differentiation,for
R11699	T38593	T38592	prep	of,differentiation
R11700	T38594	T38593	pobj	RPCs,of
R11701	T38595	T38592	prep	into,differentiation
R11702	T38596	T38595	pobj	RTCs,into
R11703	T38597	T38589	punct	", ",required
R11704	T38598	T38589	cc	but,required
R11705	T38599	T38589	conj	is,required
R11706	T38600	T38599	acomp	essential,is
R11707	T38601	T38602	aux	to,couple
R11708	T38602	T38599	advcl	couple,is
R11709	T38603	T38604	compound	RTC,birth
R11710	T38604	T38602	dobj	birth,couple
R11711	T38605	T38602	prep	to,couple
R11712	T38606	T38607	amod	terminal,mitosis
R11713	T38607	T38605	pobj	mitosis,to
R11714	T38608	T38602	punct	", ",couple
R11715	T38609	T38610	advmod	thus,locking
R11716	T38610	T38602	advcl	locking,couple
R11717	T38611	T38610	dobj	them,locking
R11718	T38612	T38613	advmod	out,of
R11719	T38613	T38610	oprd	of,locking
R11720	T38614	T38613	pobj	cycle,of
R11721	T38615	T38580	punct	.,appear
R11722	T38617	T38618	nsubj	Rb,performs
R11723	T38619	T38620	det	this,function
R11724	T38620	T38618	dobj	function,performs
R11725	T38621	T38618	prep	by,performs
R11726	T38622	T38621	pcomp	inhibiting,by
R11727	T38623	T38622	dobj	E2f1,inhibiting
R11728	T38624	T38618	punct	.,performs
R11729	T38626	T38627	nsubjpass	Rb,required
R11730	T38628	T38627	auxpass	is,required
R11731	T38629	T38627	advmod	also,required
R11732	T38630	T38627	prep	for,required
R11733	T38631	T38632	compound	SAC,differentiation
R11734	T38632	T38630	pobj	differentiation,for
R11735	T38633	T38627	punct	", ",required
R11736	T38634	T38627	cc	and,required
R11737	T38635	T38636	prep	in,acts
R11738	T38636	T38627	conj	acts,required
R11739	T38637	T38638	det	this,case
R11740	T38638	T38635	pobj	case,in
R11741	T38639	T38636	punct	", ",acts
R11742	T38640	T38636	prep	by,acts
R11743	T38641	T38640	pcomp	inhibiting,by
R11744	T38642	T38641	dobj	E2f3a,inhibiting
R11745	T38643	T38627	punct	.,required
R11746	T38645	T38646	expl	There,is
R11747	T38647	T38648	det	no,evidence
R11748	T38648	T38646	attr	evidence,is
R11749	T38649	T38648	amod	direct,evidence
R11750	T38650	T38651	mark	that,required
R11751	T38651	T38648	acl	required,evidence
R11752	T38652	T38651	nsubjpass	Rb,required
R11753	T38653	T38651	auxpass	is,required
R11754	T38654	T38651	prep	for,required
R11755	T38655	T38656	amod	terminal,differentiation
R11756	T38656	T38654	pobj	differentiation,for
R11757	T38657	T38656	prep	of,differentiation
R11758	T38658	T38659	amod	other,types
R11759	T38659	T38657	pobj	types,of
R11760	T38660	T38659	compound	cell,types
R11761	T38661	T38646	punct	.,is
R11762	T38663	T38664	compound	Colour,codes
R11763	T38665	T38664	cc	and,codes
R11764	T38666	T38664	conj	abbreviations,codes
R11765	T38667	T38664	prep	as,codes
R11766	T38668	T38667	prep	in,as
R11767	T38669	T38670	compound	Figure,1A
R11768	T38670	T38668	pobj	1A,in
R11769	T38671	T38664	punct	.,codes
R9167	T30795	T30794	punct	-,DNA
R9168	T30796	T30794	amod	free,DNA
R9169	T30797	T30798	punct	", ",Ambion
R9170	T30798	T30792	parataxis	Ambion,DNase
R9171	T30799	T30798	punct	", ",Ambion
R9172	T30800	T30798	npadvmod	http://www.ambion.com,Ambion
R9173	T30801	T30798	punct	),Ambion
R9174	T30802	T30803	aux	to,remove
R9175	T30803	T30785	advcl	remove,followed
R9176	T30804	T30805	compound	DNA,contamination
R9177	T30805	T30803	dobj	contamination,remove
R7272	T24763	T24745	conj	proposed,contested
R7273	T24764	T24765	punct	[,63
R7274	T24765	T24763	parataxis	63,proposed
R7275	T24766	T24765	nummod	62,63
R7276	T24767	T24765	punct	",",63
R7277	T24768	T24765	punct	],63
R7278	T24769	T24763	punct	", ",proposed
R7279	T24770	T24771	cc	but,involving
R7280	T24771	T24763	dep	involving,proposed
R7281	T24772	T24771	neg	not,involving
R7282	T24773	T24774	compound	E2f,repression
R7283	T24774	T24771	dobj	repression,involving
R7284	T24775	T24763	punct	.,proposed
R7285	T24777	T24778	advmod	Strikingly,discovered
R7286	T24779	T24778	punct	", ",discovered
R7287	T24780	T24778	advmod	however,discovered
R7288	T24781	T24778	punct	", ",discovered
R7289	T24782	T24778	nsubj	we,discovered
R7290	T24783	T24784	mark	that,promotes
R7291	T24784	T24778	ccomp	promotes,discovered
R7292	T24785	T24784	nsubj	Rb,promotes
R7293	T24786	T24787	compound	SAC,differentiation
R7294	T24787	T24784	dobj	differentiation,promotes
R7295	T24788	T24784	prep	through,promotes
R7296	T24789	T24788	pobj	E2f3,through
R7297	T24790	T24791	punct	(,Figure
R7298	T24791	T24784	parataxis	Figure,promotes
R7299	T24792	T24791	nummod	8,Figure
R7300	T24793	T24791	punct	),Figure
R7301	T24794	T24778	punct	.,discovered
R7302	T24803	T24804	amod	a,"tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati"
R7303	T24806	T24807	advmod	o,f
R7304	T24807	T24805	oprd	f,on
R7305	T24809	T24810	compound	SAC,differentiation
R7306	T24820	T24823	ccomp	was,rescued
R7390	T24912	T24911	prep	of,subset
R7391	T24913	T24914	compound	CNS,neurons
R7392	T24914	T24912	pobj	neurons,of
R7393	T24915	T24916	punct	(,work
R7394	T24916	T24907	parataxis	work,expressed
R7395	T24917	T24916	det	this,work
R7396	T24918	T24916	punct	),work
R7397	T24919	T24907	cc	and,expressed
R7398	T24920	T24907	conj	drives,expressed
R7399	T24921	T24922	amod	specific,defects
R7401	T24923	T24924	compound	cell,cycle
R9897	T32554	T32553	punct	.,Statistics
R9898	T32556	T32557	amod	Different,genotypes
R9899	T32557	T32558	nsubjpass	genotypes,evaluated
R9900	T32559	T32558	auxpass	were,evaluated
R9901	T32560	T32558	advcl	using,evaluated
R9902	T32561	T32560	dobj	analysis,using
R9903	T32562	T32561	prep	of,analysis
R9904	T32563	T32562	pobj	variance,of
R9905	T32564	T32561	punct	(,analysis
R9906	T32565	T32561	appos	ANOVA,analysis
R9907	T32566	T32561	punct	),analysis
R9908	T32567	T32561	acl	followed,analysis
R9909	T32568	T32567	agent	by,followed
R9910	T32569	T32570	det	the,test
R9911	T32570	T32568	pobj	test,by
R9912	T32571	T32572	nmod	Tukey,difference
R9913	T32572	T32570	nmod	difference,test
R9914	T32573	T32572	advmod	honestly,difference
R9915	T32574	T32572	amod	significant,difference
R9916	T32575	T32572	punct	(,difference
R9917	T32576	T32572	appos	HSD,difference
R9918	T32577	T32570	punct	),test
R9919	T32578	T32570	cc	or,test
R9920	T32579	T32580	compound	Fisher,test
R9921	T32580	T32570	conj	test,test
R9922	T32581	T32582	punct	(,program
R9924	T32583	T32582	compound	XLSTAT,program
R5544	T18739	T18735	prep	in,colocalize
R5545	T18740	T18739	pobj	SACs,in
R5546	T18741	T18735	cc	and,colocalize
R5547	T18742	T18743	mark	that,triggers
R5548	T18743	T18735	conj	triggers,colocalize
R5549	T18744	T18743	nsubj	E2f3,triggers
R5550	T18745	T18743	dobj	defects,triggers
R5551	T18746	T18745	prep	in,defects
R5552	T18747	T18748	compound	SAC,differentiation
R5553	T18748	T18746	pobj	differentiation,in
R5554	T18749	T18750	mark	because,expressed
R5555	T18750	T18743	advcl	expressed,triggers
R5556	T18751	T18750	nsubjpass	it,expressed
R5557	T18752	T18750	auxpass	is,expressed
R5558	T18753	T18750	advmod	specifically,expressed
R5559	T18754	T18750	prep	in,expressed
R5560	T18755	T18756	det	these,neurons
R5561	T18756	T18754	pobj	neurons,in
R5562	T18757	T18756	amod	retinal,neurons
R5563	T18758	T18733	punct	.,suggest
R5564	T18760	T18761	nsubj	We,found
R5565	T18762	T18761	advmod	also,found
R5566	T18763	T18764	mark	that,is
R5567	T18764	T18761	ccomp	is,found
R5568	T18765	T18764	nsubj	E2f3,is
R5569	T18766	T18764	acomp	present,is
R5570	T18767	T18764	prep	in,is
R5571	T18768	T18769	det	a,subset
R5572	T18769	T18767	pobj	subset,in
R5573	T18770	T18769	amod	specific,subset
R5574	T18771	T18769	prep	of,subset
R5575	T18772	T18773	amod	mature,neurons
R5576	T18773	T18771	pobj	neurons,of
R5577	T18774	T18769	prep	in,subset
R5578	T18775	T18776	amod	various,regions
R5579	T18776	T18774	pobj	regions,in
R5580	T18777	T18776	compound	brain,regions
R5581	T18778	T18779	punct	(,shown
R5582	T18779	T18764	parataxis	shown,is
R5583	T18780	T18779	nsubj	data,shown
R5584	T18781	T18779	neg	not,shown
R5585	T18782	T18779	punct	),shown
R5586	T18783	T18761	punct	.,found
R6136	T20662	T20658	pobj	modifications,by
R6137	T20663	T20662	amod	post-translational,modifications
R6138	T20664	T20627	punct	.,show
R6139	T20666	T20667	nsubj	We,examined
R6140	T20668	T20667	advmod	also,examined
R6141	T20669	T20670	det	the,distribution
R6142	T20670	T20667	dobj	distribution,examined
R6143	T20671	T20670	prep	of,distribution
R6144	T20672	T20673	amod	other,regulators
R6145	T20673	T20671	pobj	regulators,of
R6146	T20674	T20675	compound	cell,cycle
R6147	T20675	T20673	compound	cycle,regulators
R6148	T20676	T20667	prep	during,examined
R6149	T20677	T20678	amod	retinal,development
R6150	T20678	T20676	pobj	development,during
R6151	T20679	T20667	punct	.,examined
R6152	T20681	T20682	prep	Like,was
R6153	T20683	T20681	pobj	E2f3a,Like
R6154	T20684	T20682	punct	", ",was
R6155	T20685	T20682	nsubj	Rb,was
R2151	T7562	T7561	neg	not,but
R2152	T7563	T7559	conj	E2f2,E2f1
R2154	T7564	T7563	cc	or,E2f2
R2156	T7565	T7563	conj	E2f3,E2f2
R2157	T7566	T7558	punct	", ",blocked
R2158	T7567	T7568	det	this,death
R2159	T7568	T7558	dobj	death,blocked
R2161	T7569	T7568	amod	ectopic,death
R2162	T7570	T7568	compound	cell,death
R2164	T7571	T7558	prep	in,blocked
R2165	T7572	T7573	det	a,fashion
R2166	T7573	T7571	pobj	fashion,in
R2167	T7574	T7575	npadvmod	dose,dependent
R2168	T7575	T7573	amod	dependent,fashion
R2170	T7576	T7575	punct	-,dependent
R2171	T7577	T7578	punct	(,1D
R2173	T7578	T7558	parataxis	1D,blocked
R2174	T7579	T7578	compound	Figures,1D
R2175	T7580	T7578	punct	", ",1D
R2176	T7581	T7578	conj	1G,1D
R2178	T7582	T7581	punct	", ",1G
R2179	T7583	T7581	cc	and,1G
R2180	T7584	T7581	conj	S1B,1G
R2182	T7585	T7578	punct	),1D
R2183	T7586	T7558	punct	.,blocked
R2163	T7588	T7589	aux	To,investigate
R2169	T7589	T7590	advcl	investigate,assessed
R2172	T7591	T7592	det	the,mechanism
R2177	T7592	T7589	dobj	mechanism,investigate
R2181	T7593	T7592	amod	molecular,mechanism
R2184	T7594	T7595	dep	that,underlies
R2185	T7595	T7592	relcl	underlies,mechanism
R2186	T7596	T7597	det	the,role
R2187	T7597	T7595	dobj	role,underlies
R2188	T7598	T7597	amod	unique,role
R2191	T7599	T7597	prep	of,role
R2194	T7600	T7599	pobj	E2f1,of
R2198	T7601	T7590	punct	", ",assessed
R2201	T7602	T7590	nsubj	we,assessed
R2204	T7603	T7604	det	the,expression
R2208	T7604	T7590	dobj	expression,assessed
R2210	T7605	T7604	prep	of,expression
R2212	T7606	T7607	amod	known,targets
R2214	T7607	T7605	pobj	targets,of
R2218	T7608	T7607	compound	E2f,targets
R2222	T7609	T7610	advmod	as,as
R2225	T7610	T7607	cc	as,targets
R2228	T7611	T7610	advmod	well,as
R2232	T7612	T7613	amod	other,genes
R3671	T13916	T13914	pobj	IPL,in
R3673	T13918	T13916	compound	KO,IPL
R3674	T13919	T13906	punct	", ",was
R3675	T13920	T13906	cc	and,was
R3676	T13921	T13922	det	this,defect
R3677	T13922	T13923	nsubjpass	defect,rescued
R3678	T13923	T13906	conj	rescued,was
R3679	T13924	T13923	auxpass	was,rescued
R3680	T13925	T13923	neg	not,rescued
R3681	T13926	T13923	prep	in,rescued
R3682	T13927	T13928	det	the,retina
R3683	T13928	T13926	pobj	retina,in
R3684	T13929	T13930	compound	Rb,E2f1
R3685	T13930	T13932	compound	E2f1,DKO
R3686	T13931	T13930	punct	/,E2f1
R3687	T13932	T13928	compound	DKO,retina
R3688	T13933	T13934	punct	(,3A
R3689	T13934	T13923	parataxis	3A,rescued
R3690	T13935	T13934	compound	Figure,3A
R3691	T13936	T13934	punct	),3A
R3692	T13937	T13923	punct	.,rescued
R3693	T13939	T13940	nsubj	We,quantified
R3694	T13941	T13942	nmod	Calb2,bodies
R3695	T13942	T13940	dobj	bodies,quantified
R3696	T13943	T13941	punct	+,Calb2
R3726	T13980	T13979	amod	h,e
R3727	T13987	T13986	advmod	l,Ca
R3728	T13990	T13989	punct	+,b2
R3729	T13993	T13994	compound	r,a
R3730	T13996	T13995	parataxis	s,c
R3731	T14004	T14001	punct	", ",are
R3732	T14005	T14006	det	the,tracks
R3733	T14006	T14001	nsubj	tracks,are
R3734	T14007	T14006	nummod	two,tracks
R3735	T14008	T14006	amod	outer,tracks
R3736	T14009	T14001	prep	from,are
R3737	T14010	T14009	pobj	SACs,from
R3738	T14011	T14010	punct	", ",SACs
R3739	T14012	T14010	acl	named,SACs
R3740	T14013	T14012	prep	after,named
R3741	T14014	T14015	poss	their,morphology
R401	T4027	T4006	conj	form,reside
R414	T4031	T4026	conj	cells,ganglion
R418	T4032	T4033	det	the,layer
R420	T4033	T4027	dobj	layer,form
R425	T4034	T4035	compound	ganglion,cell
R433	T4035	T4033	compound	cell,layer
R437	T4036	T4033	punct	(,layer
R441	T4037	T4033	appos	GCL,layer
R445	T4038	T4027	punct	),form
R449	T4039	T4040	punct	(,1A
R453	T4040	T4027	parataxis	1A,form
R454	T4041	T4040	compound	Figure,1A
R455	T4042	T4040	punct	),1A
R456	T4043	T4027	punct	.,form
R457	T4045	T4046	det	The,layer
R458	T4046	T4049	nsubj	layer,house
R459	T4047	T4046	amod	outer,layer
R460	T4048	T4046	compound	plexiform,layer
R461	T4050	T4046	punct	(,layer
R462	T4051	T4046	appos	OPL,layer
R464	T4052	T4046	punct	),layer
R465	T4053	T4046	cc	and,layer
R466	T4054	T4055	amod	inner,layer
R467	T4055	T4046	conj	layer,layer
R468	T4056	T4055	compound	plexiform,layer
R469	T4057	T4055	punct	(,layer
R470	T4058	T4055	appos	IPL,layer
R471	T4059	T4049	punct	),house
R472	T4060	T4061	amod	synaptic,connections
R473	T4061	T4049	dobj	connections,house
R474	T4062	T4061	acl	separating,connections
R475	T4063	T4064	det	the,INL
R476	T4064	T4062	dobj	INL,separating
R477	T4065	T4064	compound	ONL,INL
R478	T4066	T4064	punct	/,INL
R479	T4067	T4064	cc	and,INL
R480	T4068	T4069	compound	INL,GCL
R463	T4086	T4083	conj	o,s
R483	T4104	T4103	prep	for,critical
R484	T4105	T4106	compound	cell,cycle
R486	T4106	T4107	compound	cycle,exit
R487	T4107	T4104	pobj	exit,for
R489	T4109	T4110	amod	retinal,cell
R490	T4110	T4112	compound	cell,birth
R491	T4111	T4110	compound	transition,cell
R493	T4112	T4108	pobj	birth,during
R494	T4159	T4156	appos	E2fs,factors
R495	T4115	T4116	nmod	Rb,knockout
R496	T4116	T4117	nmod	knockout,RTCs
R497	T4117	T4121	nsubj	RTCs,continue
R498	T4118	T4116	punct	(,knockout
R499	T4160	T4156	punct	),factors
R500	T4119	T4116	appos	KO,knockout
R501	T4120	T4117	punct	),RTCs
R502	T4161	T4162	punct	(,1B

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T552	0-2	PR_EXT:000013773	denotes	Rb
T553	12-20	CL:0000540	denotes	Neuronal
T554	21-36	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T555	45-49	CL_GO_EXT:cell	denotes	Cell
T556	45-55	GO:0007049	denotes	Cell-Cycle
T557	68-78	GO:0065007	denotes	Regulation
T558	82-87	PR_EXT:000028775	denotes	E2f3a
T559	177-199	PR_EXT:000013773	denotes	retinoblastoma protein
T560	192-199	CHEBI_PR_EXT:protein	denotes	protein
T561	201-203	PR_EXT:000013773	denotes	Rb
T562	214-220	UBERON_EXT:neural_tissue_or_nerve_or_nervous_system	denotes	neural
T563	221-236	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T564	290-292	PR_EXT:000013773	denotes	Rb
T565	309-313	CL_GO_EXT:cell	denotes	cell
T566	309-319	GO:0007049	denotes	cell cycle
T567	338-346	_FRAGMENT	denotes	death of
T568	352-359	GO:0070997	denotes	neurons
T569	352-359	CL:0000540	denotes	neurons
T570	364-379	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T571	453-468	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T572	507-519	_FRAGMENT	denotes	responses in
T573	541-546	GO:0051716	denotes	cells
T574	520-522	PR_EXT:000013773	denotes	Rb
T575	533-540	UBERON:0000966	denotes	retinal
T576	533-546	CL:0009004	denotes	retinal cells
T577	541-546	CL_GO_EXT:cell	denotes	cells
T578	551-558	SO_EXT:sequence_rescue_process	denotes	rescued
T579	585-594	GO:0006915	denotes	apoptosis
T580	623-631	SO_EXT:sequence_deletion_process	denotes	deleting
T581	632-656	_FRAGMENT	denotes	E2f transcription factor
T582	663-664	PR_EXT:000006852	denotes	1
T583	636-649	GO_EXT:transcription	denotes	transcription
T584	636-656	GO_EXT:transcription_factor	denotes	transcription factor
T585	658-661	_FRAGMENT	denotes	E2f
T586	689-693	CL_GO_EXT:cell	denotes	cell
T587	715-722	SO_EXT:sequence_rescue_process	denotes	rescued
T588	730-734	SO_EXT:sequence_nullness	denotes	null
T589	735-741	UBERON:0000966	denotes	retina
T590	750-754	CL_GO_EXT:cell	denotes	cell
T591	750-760	GO:0007049	denotes	cell-cycle
T592	773-788	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T593	823-837	CL:0000561	denotes	amacrine cells
T594	832-837	CL_GO_EXT:cell	denotes	cells
T595	846-857	CHEBI:15355	denotes	cholinergic
T596	858-870	CL:0000099	denotes	interneurons
T597	963-965	PR_EXT:000013773	denotes	Rb
T598	1009-1013	PR_EXT:E2F	denotes	E2fs
T599	1030-1045	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T600	1062-1068	UBERON:0000479	denotes	tissue
T601	1108-1110	PR_EXT:000013773	denotes	Rb
T602	1124-1139	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T603	1154-1158	PR_EXT:000006854	denotes	E2f3
T604	1173-1177	PR_EXT:000006854	denotes	E2f3
T605	1178-1186	SO_EXT:0001060	denotes	isoforms
T606	1229-1235	UBERON:0000966	denotes	retina
T607	1278-1289	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T608	1281-1289	CL_GO_EXT:cell	denotes	cellular
T609	1332-1334	PR_EXT:000013773	denotes	Rb
T610	1347-1356	GO:0044838	denotes	quiescent
T611	1357-1362	CL_GO_EXT:cell	denotes	cells
T612	1427-1430	PR_EXT:E2F	denotes	E2f
T613	1431-1438	SO_EXT:0001060	denotes	isoform
T614	1469-1471	PR_EXT:000013773	denotes	Rb
T615	1485-1500	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T616	1509-1514	PR_EXT:000028775	denotes	E2f3a
T617	1560-1562	PR_EXT:000013773	denotes	Rb
T618	1563-1572	GO:0065007	denotes	regulates
T619	1573-1579	UBERON_EXT:neural_tissue_or_nerve_or_nervous_system	denotes	neural
T620	1580-1595	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T621	1651-1656	PR_EXT:000028775	denotes	E2f3a
T622	1678-1684	UBERON:0000479	denotes	tissue
T3555	3195-3201	UBERON:0000966	denotes	retina
T3556	3220-3226	UBERON:0000479	denotes	tissue
T3557	3236-3248	GO:0022008	denotes	neurogenesis
T3558	3321-3328	UBERON:0000966	denotes	retinal
T3559	3321-3344	CL:0002672	denotes	retinal progenitor cell
T3560	3340-3344	CL_GO_EXT:cell	denotes	cell
T3561	3340-3344	_FRAGMENT	denotes	cell
T3562	3351-3364	GO:0008283	denotes	proliferation
T3563	3346-3349	CL:0002672	denotes	RPC
T3564	3392-3399	GO:0007067	denotes	mitotic
T3565	3400-3407	UBERON:0000966	denotes	retinal
T3566	3419-3424	CL_GO_EXT:cell	denotes	cells
T3567	3490-3505	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3568	3521-3525	CL_GO_EXT:cell	denotes	cell
T3569	3549-3553	CL:0002672	denotes	RPCs
T3570	3583-3587	CL_GO_EXT:cell	denotes	cell
T3571	3583-3593	GO:0007049	denotes	cell cycle
T3572	3715-3730	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3573	3735-3739	CL_GO_EXT:cell	denotes	cell
T3574	3735-3745	GO:0007049	denotes	cell cycle
T3575	3768-3775	GO:0007067	denotes	mitotic
T3576	3781-3788	GO_EXT:biological_movement_or_translocation_process	denotes	migrate
T3577	3808-3822	UBERON:0001781	denotes	retinal layers
T3578	3824-3828	CL:0000604	denotes	Rods
T3579	3833-3838	CL:0000573	denotes	cones
T3580	3851-3870	UBERON:0001789	denotes	outer nuclear layer
T3581	3857-3864	GO:0005634	denotes	nuclear
T3582	3872-3875	UBERON:0001789	denotes	ONL
T3583	3878-3888	_FRAGMENT	denotes	horizontal
T3584	3912-3917	CL:0000745	denotes	cells
T3585	3890-3897	_FRAGMENT	denotes	bipolar
T3586	3912-3917	CL:0000103	denotes	cells
T3587	3903-3917	CL:0000561	denotes	amacrine cells
T3588	3912-3917	CL_GO_EXT:cell	denotes	cells
T3589	3930-3946	CL:0011107	denotes	Müller glia cell
T3590	3942-3953	GO:0044297	denotes	cell bodies
T3591	3969-3988	UBERON:0001791	denotes	inner nuclear layer
T3592	3975-3982	GO:0005634	denotes	nuclear
T3593	3990-3993	UBERON:0001791	denotes	INL
T3594	4000-4008	UBERON:0000045	denotes	ganglion
T3595	4000-4008	_FRAGMENT	denotes	ganglion
T3596	4032-4037	CL:0000740	denotes	cells
T3644	6143-6153	GO:0007049	denotes	cell cycle
T3645	6157-6164	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T3646	6180-6183	PR_EXT:E2F	denotes	E2f
T3647	6184-6197	GO_EXT:transcription	denotes	transcription
T3648	6184-6205	GO_EXT:transcription_factor	denotes	transcription factors
T3649	6207-6211	PR_EXT:E2F	denotes	E2fs
T3650	6243-6256	GO_EXT:transcription	denotes	transcription
T3651	6243-6264	GO_EXT:transcription_factor	denotes	transcription factors
T3652	6270-6274	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T3653	6275-6285	NCBITaxon:10508	denotes	adenoviral
T3654	6289-6299	GO:0065007	denotes	regulatory
T3655	6289-6308	SO_EXT:0005836	denotes	regulatory elements
T3656	6347-6351	CL_GO_EXT:cell	denotes	cell
T3657	6347-6357	GO:0007049	denotes	cell cycle
T3658	6358-6368	GO_EXT:regulator	denotes	regulators
T3659	6376-6380	PR_EXT:E2F	denotes	E2fs
T3660	6381-6385	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T3661	6389-6392	CHEBI_SO_EXT:DNA	denotes	DNA
T3662	6402-6408	GO_EXT:dimer_macromolecular_complex	denotes	dimers
T3663	6414-6422	CHEBI_PR_EXT:protein	denotes	proteins
T3664	6438-6442	PR_EXT:TFDP	denotes	Tfdp
T3665	6451-6455	PR_EXT:000006852	denotes	E2f1
T3666	6457-6461	PR_EXT:000006853	denotes	E2f2
T3667	6467-6472	PR_EXT:000028775	denotes	E2f3a
T3668	6489-6493	PR_EXT:E2F	denotes	E2fs
T3669	6517-6527	CL:0000057	denotes	fibroblast
T3670	6554-6569	GO_EXT:transcription	denotes	transcriptional
T3671	6599-6610	CL:0000057	denotes	fibroblasts
T3672	6646-6651	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bound
T3673	6655-6657	PR_EXT:000013773	denotes	Rb
T3674	6685-6687	PR_EXT:000013773	denotes	Rb
T3675	6691-6698	UBERON:0000922	denotes	embryos
T3676	6706-6713	SO_EXT:sequence_rescue_process	denotes	rescued
T3677	6746-6753	UBERON:0000479	denotes	tissues
T3678	6770-6774	PR_EXT:000006852	denotes	E2f1
T3679	6776-6780	PR_EXT:000006853	denotes	E2f2
T3680	6785-6789	PR_EXT:000006854	denotes	E2f3
T3681	6835-6837	PR_EXT:000013773	denotes	Rb
T3682	6895-6899	PR_EXT:000006855	denotes	E2f4
T3683	6904-6908	PR_EXT:000006856	denotes	E2f5
T3684	6935-6939	PR_EXT:E2F	denotes	E2fs
T3685	7013-7017	SO_EXT:0000704	denotes	gene
T3686	7013-7027	GO:0016458	denotes	gene silencing
T3687	7031-7040	GO:0044838	denotes	quiescent
T3688	7044-7058	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T3689	7059-7064	CL_GO_EXT:cell	denotes	cells
T3690	7077-7081	PR_EXT:E2F	denotes	E2fs
T3691	7099-7108	GO:0006915	denotes	apoptosis
T3692	7116-7118	PR_EXT:000013773	denotes	Rb
T3693	7122-7128	UBERON:0000966	denotes	retina
T3694	7154-7158	PR_EXT:000006852	denotes	E2f1
T3695	7190-7199	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T3696	7292-7296	PR_EXT:000006852	denotes	E2f1
T3697	7300-7304	PR_EXT:000006854	denotes	E2f3
T3698	7305-7313	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T3699	7314-7321	SO_EXT:sequence_rescue_process	denotes	rescues
T3700	7322-7331	GO:0006915	denotes	apoptosis
T3701	7350-7372	UBERON:0001017	denotes	central nervous system
T3702	7374-7377	UBERON:0001017	denotes	CNS
T3703	7382-7384	PR_EXT:000013773	denotes	Rb
T3704	7388-7395	UBERON:0000922	denotes	embryos
T3705	7418-7421	UBERON:0001017	denotes	CNS
T3706	7422-7431	GO:0006915	denotes	apoptosis
T3707	7470-7479	UBERON:0001987	denotes	placental
T3708	7526-7530	PR_EXT:000006854	denotes	E2f3
T3709	7539-7548	GO:0006915	denotes	apoptosis
T3710	7552-7563	CL:0000057	denotes	fibroblasts
T3711	7599-7603	PR_EXT:000006852	denotes	E2f1
T3712	7644-7648	PR_EXT:000006854	denotes	E2f3
T3713	7665-7674	GO:0006915	denotes	apoptosis
T3714	7682-7684	PR_EXT:000013773	denotes	Rb
T3715	7688-7692	CL_GO_EXT:cell	denotes	cell
T3716	7728-7732	PR_EXT:E2F	denotes	E2fs
T3717	7741-7746	GO:0016265	denotes	death
T3718	7759-7761	PR_EXT:000013773	denotes	Rb
T3719	7765-7772	UBERON:0000479	denotes	tissues
T3720	7826-7828	PR_EXT:000013773	denotes	Rb
T3721	7829-7837	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T3722	7893-7896	PR_EXT:E2F	denotes	E2f
T3723	7929-7933	PR_EXT:000006854	denotes	E2f3
T3724	7934-7942	SO_EXT:0001060	denotes	isoforms
T3725	7956-7965	SO_EXT:0000167	denotes	promoters
T3726	8040-8045	SO_EXT:0000147	denotes	exons
T3727	8052-8057	PR_EXT:000028775	denotes	E2f3a
T3728	8108-8112	PR_EXT:E2F	denotes	E2fs
T3729	8118-8128	GO:0010467	denotes	expression
T3730	8145-8154	GO:0044838	denotes	quiescent
T3731	8155-8160	CL_GO_EXT:cell	denotes	cells
T3732	8215-8219	PR_EXT:E2F	denotes	E2fs
T3733	8240-8249	GO:0044838	denotes	quiescent
T3734	8263-8268	CL_GO_EXT:cell	denotes	cells
T3735	8277-8286	GO:0044838	denotes	quiescent
T3736	8287-8298	CL:0000057	denotes	fibroblasts
T3737	8328-8330	PR_EXT:000013773	denotes	Rb
T3738	8388-8397	GO:0016458	denotes	silencing
T3739	8402-8408	PR_EXT:000005279	denotes	Cdkn2d
T3740	8410-8416	PR_EXT:000005279	denotes	p19Arf
T3741	8438-8443	CL_GO_EXT:cell	denotes	cells
T3742	8472-8476	PR_EXT:E2F	denotes	E2fs
T3743	8495-8503	SO_EXT:0001060	denotes	isoforms
T3744	8523-8527	CHEBI_SO_EXT:mRNA	denotes	mRNA
T3745	8559-8563	PR_EXT:000006852	denotes	E2f1
T3746	8568-8572	PR_EXT:000006853	denotes	E2f2
T3747	8592-8595	PR_EXT:E2F	denotes	E2f
T3748	8596-8604	SO_EXT:0001060	denotes	isoforms
T3749	8626-8630	PR_EXT:E2F	denotes	E2fs
T3750	8640-8649	GO:0065007	denotes	regulated
T3751	8653-8664	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T3752	8656-8664	CL_GO_EXT:cell	denotes	cellular
T3753	8665-8677	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T3754	8744-8748	PR_EXT:E2F	denotes	E2fs
T3755	8785-8789	PR_EXT:E2F	denotes	E2fs
T3756	8819-8822	PR_EXT:E2F	denotes	E2f
T3757	8823-8831	SO_EXT:0001060	denotes	isoforms
T3758	8895-8897	PR_EXT:000013773	denotes	Rb
T3759	8912-8920	CL:0000540	denotes	neuronal
T3760	8921-8936	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3761	9005-9020	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3762	9089-9094	GO:0016265	denotes	death
T3763	9099-9101	PR_EXT:000013773	denotes	Rb
T3764	9107-9115	GO:0065007	denotes	regulate
T3765	9116-9131	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3766	9196-9203	CL:0000540	denotes	neurons
T3767	9261-9265	CL_GO_EXT:cell	denotes	cell
T3768	9278-9280	PR_EXT:000013773	denotes	Rb
T3769	9293-9308	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3770	9327-9333	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T3771	9338-9342	UBERON_EXT:bone_element_or_tissue	denotes	bone
T3772	9370-9373	PR_EXT:E2F	denotes	E2f
T3773	9408-9414	UBERON:0000479	denotes	tissue
T3774	9424-9437	GO_EXT:transcription	denotes	transcription
T3775	9424-9445	GO_EXT:transcription_factor	denotes	transcription factors
T3776	9474-9480	UBERON:0000966	denotes	retina
T3777	9518-9520	PR_EXT:000013773	denotes	Rb
T3778	9524-9528	CL:0000604	denotes	rods
T3779	9548-9550	PR_EXT:000013773	denotes	Rb
T3780	9578-9591	GO:0009653	denotes	morphogenesis
T3781	9606-9612	UBERON:0000966	denotes	retina
T3782	9645-9660	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3783	9676-9678	PR_EXT:000013773	denotes	Rb
T3784	9682-9688	CL:0000540	denotes	neuron
T3785	9744-9753	GO:0006915	denotes	apoptosis
T3786	9797-9815	_FRAGMENT	denotes	differentiation of
T3787	9822-9827	GO:0030154	denotes	cells
T3788	9816-9818	PR_EXT:000013773	denotes	Rb
T3789	9822-9827	CL_GO_EXT:cell	denotes	cells
T3790	9854-9867	GO:0008283	denotes	proliferation
T3791	9872-9877	GO:0016265	denotes	death
T3792	9903-9905	PR_EXT:000013773	denotes	Rb
T3793	9934-9939	GO:0016265	denotes	death
T3794	9954-9958	PR_EXT:000006852	denotes	E2f1
T3795	9964-9968	PR_EXT:000006853	denotes	E2f2
T3796	9972-9976	PR_EXT:000006854	denotes	E2f3
T3797	10002-10009	SO_EXT:sequence_rescue_process	denotes	rescued
T3798	10016-10023	UBERON:0000966	denotes	retinal
T3799	10024-10031	CL:0000540	denotes	neurons
T3800	10043-10047	CL:0000604	denotes	rods
T3801	10059-10073	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T3802	10120-10126	UBERON:0000966	denotes	retina
T3803	10136-10151	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3804	10186-10188	PR_EXT:000013773	denotes	Rb
T3805	10231-10233	PR_EXT:000013773	denotes	Rb
T3806	10234-10238	PR_EXT:000006852	denotes	E2f1
T3807	10246-10250	SO_EXT:sequence_nullness	denotes	null
T3808	10251-10258	SO_EXT:sequence_rescue_process	denotes	rescued
T3809	10259-10265	UBERON:0000966	denotes	retina
T3810	10277-10292	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3811	10303-10314	CHEBI:15355	denotes	cholinergic
T3812	10325-10339	CL:0000561	denotes	amacrine cells
T3813	10334-10339	CL_GO_EXT:cell	denotes	cells
T3814	10394-10406	CL:0000099	denotes	interneurons
T3815	10516-10531	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3816	10591-10593	PR_EXT:000013773	denotes	Rb
T3817	10603-10618	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3818	10627-10630	PR_EXT:E2F	denotes	E2f
T3819	10643-10649	UBERON:0000479	denotes	tissue
T3820	10659-10672	GO_EXT:transcription	denotes	transcription
T3821	10659-10680	GO_EXT:transcription_factor	denotes	transcription factors
T3822	10695-10697	PR_EXT:000013773	denotes	Rb
T3823	10734-10738	PR_EXT:000006854	denotes	E2f3
T3824	10751-10753	PR_EXT:000013773	denotes	Rb
T3825	10754-10758	SO_EXT:sequence_nullness	denotes	null
T3826	10789-10793	PR_EXT:000006854	denotes	E2f3
T3827	10794-10804	GO:0010467	denotes	expression
T3828	10814-10819	CL_GO_EXT:cell	denotes	cells
T3829	10825-10829	PR_EXT:000006854	denotes	E2f3
T3830	10830-10840	GO:0010467	denotes	expression
T3831	10855-10862	CL:0000540	denotes	neurons
T3832	10868-10882	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T3833	10891-10893	PR_EXT:000013773	denotes	Rb
T3834	10895-10899	PR_EXT:000006854	denotes	E2f3
T3835	10946-10949	UBERON:0001017	denotes	CNS
T3836	10946-10957	CL:0000117	denotes	CNS neurons
T3837	11014-11016	PR_EXT:000013773	denotes	Rb
T3838	11029-11041	GO:0022008	denotes	neurogenesis
T3839	11108-11112	PR_EXT:000006854	denotes	E2f3
T3840	11113-11120	SO_EXT:0001060	denotes	isoform
T3841	11121-11123	PR_EXT:000013773	denotes	Rb
T3842	11135-11142	GO:0065007	denotes	control
T3843	11147-11162	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3844	11179-11181	PR_EXT:000013773	denotes	Rb
T3845	11194-11203	GO:0044838	denotes	quiescent
T3846	11204-11215	CL:0000057	denotes	fibroblasts
T3847	11275-11280	PR_EXT:000028775	denotes	E2f3a
T3848	11318-11325	SO_EXT:0001060	denotes	isoform
T3849	11335-11339	SO_EXT:sequence_nullness	denotes	null
T3850	11340-11345	NCBITaxon:10088	denotes	mouse
T3851	11359-11361	PR_EXT:000013773	denotes	Rb
T3852	11373-11388	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3853	11397-11402	PR_EXT:000028775	denotes	E2f3a
T3854	11425-11429	PR_EXT:000006852	denotes	E2f1
T3855	11463-11468	GO:0016265	denotes	death
T3856	11470-11472	PR_EXT:000013773	denotes	Rb
T3857	11478-11486	GO:0065007	denotes	regulate
T3858	11487-11495	CL:0000540	denotes	neuronal
T3859	11496-11511	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3860	11534-11541	CL:0000540	denotes	neurons
T3861	11569-11574	PR_EXT:000028775	denotes	E2f3a
T3862	11580-11586	UBERON:0000479	denotes	tissue
T3863	11596-11611	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T6707	11631-11633	PR_EXT:000013773	denotes	Rb
T6708	11634-11643	GO:0065007	denotes	Regulates
T6709	11657-11662	GO:0016265	denotes	Death
T6710	11671-11675	PR_EXT:000006852	denotes	E2f1
T6711	11694-11703	SO_EXT:0000902	denotes	transgene
T6712	11707-11713	SO_EXT:sequence_deletion_process	denotes	delete
T6713	11714-11720	SO:0000359	denotes	floxed
T6714	11721-11723	PR_EXT:000013773	denotes	Rb
T6715	11724-11728	SO_EXT:0000147	denotes	exon
T6716	11735-11744	UBERON:0000922	denotes	embryonic
T6717	11759-11776	UBERON:0013682	denotes	peripheral retina
T6718	11782-11784	PR_EXT:000013773	denotes	Rb
T6719	11784-11788	SO_EXT:0000346	denotes	loxP
T6720	11789-11793	SO_EXT:0000346	denotes	loxP
T6721	11800-11804	NCBITaxon:10088	denotes	mice
T6722	11810-11814	GO_EXT:breeding	denotes	bred
T6723	11836-11840	PR_EXT:000006852	denotes	E2f1
T6724	11844-11848	PR_EXT:000006853	denotes	E2f2
T6725	11890-11896	SO:0000359	denotes	floxed
T6726	11897-11901	PR_EXT:000006854	denotes	E2f3
T6727	11902-11908	SO_EXT:0001023	denotes	allele
T6728	11914-11916	PR_EXT:000013773	denotes	Rb
T6729	11916-11920	SO_EXT:0000346	denotes	loxP
T6730	11921-11925	SO_EXT:0000346	denotes	loxP
T6731	11926-11930	PR_EXT:000006852	denotes	E2f1
T6732	11930-11931	SO_EXT:normal_or_wild_type_or_present	denotes	+
T6733	11932-11933	SO_EXT:sequence_nullness_or_absence	denotes	−
T6734	11938-11940	PR_EXT:000013773	denotes	Rb
T6735	11940-11944	SO_EXT:0000346	denotes	loxP
T6736	11945-11949	SO_EXT:0000346	denotes	loxP
T6737	11950-11954	PR_EXT:000006852	denotes	E2f1
T6738	11954-11955	SO_EXT:normal_or_wild_type_or_present	denotes	+
T6739	11956-11957	SO_EXT:sequence_nullness_or_absence	denotes	−
T6740	11964-11968	NCBITaxon:10088	denotes	mice
T6741	11974-11978	GO_EXT:breeding	denotes	bred
T6742	11990-11992	PR_EXT:000013773	denotes	Rb
T6743	11992-11996	SO_EXT:0000346	denotes	loxP
T6744	11997-12001	SO_EXT:0000346	denotes	loxP
T6745	12002-12006	PR_EXT:000006852	denotes	E2f1
T6746	12006-12007	SO_EXT:sequence_nullness_or_absence	denotes	−
T6747	12008-12009	SO_EXT:sequence_nullness_or_absence	denotes	−
T6748	12016-12020	NCBITaxon:10088	denotes	mice
T6749	12142-12144	PR_EXT:000013773	denotes	Rb
T6750	12144-12148	SO_EXT:0000346	denotes	loxP
T6751	12149-12153	SO_EXT:0000346	denotes	loxP
T6752	12154-12158	PR_EXT:000006852	denotes	E2f1
T6753	12158-12159	SO_EXT:sequence_nullness_or_absence	denotes	−
T6754	12160-12161	SO_EXT:sequence_nullness_or_absence	denotes	−
T6755	12168-12185	UBERON:0013682	denotes	peripheral retina
T6756	12193-12195	PR_EXT:000013773	denotes	Rb
T6757	12196-12200	PR_EXT:000006852	denotes	E2f1
T6758	12223-12229	UBERON:0000966	denotes	retina
T6759	12279-12283	PR_EXT:000006853	denotes	E2f2
T6760	12287-12291	PR_EXT:000006854	denotes	E2f3
T6761	12306-12314	SO_EXT:sequence_deletion_process	denotes	excision
T6762	12318-12320	PR_EXT:000013773	denotes	Rb
T6763	12325-12329	PR_EXT:000006854	denotes	E2f3
T6764	12330-12337	SO_EXT:0001023	denotes	alleles
T6765	12345-12351	UBERON:0000966	denotes	retina
T6766	12423-12427	CL_GO_EXT:cell	denotes	cell
T6767	12423-12436	GO:0051301	denotes	cell division
T6768	12438-12442	NCBITaxon:10088	denotes	mice
T6769	12454-12462	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T6770	12468-12485	CHEBI:472552	denotes	bromodeoxyuridine
T6771	12487-12491	CHEBI:472552	denotes	BrdU
T6772	12504-12513	GO_EXT:killing	denotes	sacrifice
T6773	12522-12539	UBERON:0013682	denotes	peripheral retina
T6774	12553-12557	CHEBI:472552	denotes	BrdU
T6775	12621-12623	PR_EXT:000013773	denotes	Rb
T6776	12627-12634	UBERON:0000966	denotes	retinas
T6777	12679-12682	CHEBI_SO_EXT:DNA	denotes	DNA
T6778	12679-12692	GO:0071897	denotes	DNA synthesis
T6779	12760-12765	GO:0007567	denotes	natal
T6780	12789-12795	UBERON:0000966	denotes	retina
T6781	12811-12815	CHEBI:472552	denotes	BrdU
T6795	13275-13279	PR_EXT:000006852	denotes	E2f1
T6796	13284-13290	UBERON:0000966	denotes	retina
T6797	13339-13347	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T6798	13351-13355	PR_EXT:000006853	denotes	E2f2
T6799	13359-13363	PR_EXT:000006854	denotes	E2f3
T6800	13419-13426	GO:0007067	denotes	mitotic
T6801	13427-13432	CL_GO_EXT:cell	denotes	cells
T6802	13443-13457	CHEBI_EXT:phosphohistone	denotes	phosphohistone
T6803	13475-13485	GO:0042571	denotes	antibodies
T6804	13509-13513	PR_EXT:000006852	denotes	E2f1
T6805	13523-13527	PR_EXT:000006853	denotes	E2f2
T6806	13531-13535	PR_EXT:000006854	denotes	E2f3
T6807	13578-13586	SO_EXT:sequence_deletion_process	denotes	Deleting
T6808	13591-13595	PR_EXT:000006852	denotes	E2f1
T6809	13596-13602	SO_EXT:0001023	denotes	allele
T6810	13632-13639	GO:0051320	denotes	S-phase
T6811	13644-13651	GO:0007067	denotes	mitosis
T6812	13655-13657	PR_EXT:000013773	denotes	Rb
T6813	13721-13725	PR_EXT:000006852	denotes	E2f1
T6814	13753-13755	PR_EXT:000013773	denotes	Rb
T6815	13843-13847	UBERON_EXT:lens	denotes	lens
T6816	13852-13855	UBERON:0001017	denotes	CNS
T6817	13859-13861	PR_EXT:000013773	denotes	Rb
T6818	13865-13872	UBERON:0000922	denotes	embryos
T6819	13880-13888	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T6820	13907-13910	PR_EXT:E2F	denotes	E2f
T6821	13969-13971	PR_EXT:000013773	denotes	Rb
T6822	13979-13985	UBERON:0000966	denotes	retina
T6823	14014-14023	GO:0006915	denotes	apoptosis
T6824	14025-14036	GO_EXT:killing	denotes	eliminating
T6825	14042-14049	_FRAGMENT	denotes	bipolar
T6826	14063-14068	CL:0000103	denotes	cells
T6827	14054-14062	UBERON:0000045	denotes	ganglion
T6828	14054-14068	CL:0000740	denotes	ganglion cells
T6829	14063-14068	CL_GO_EXT:cell	denotes	cells
T6830	14085-14089	CL:0000604	denotes	rods
T6831	14124-14126	PR_EXT:000013773	denotes	Rb
T6832	14130-14134	CL:0000604	denotes	rods
T6833	14163-14166	UBERON:0001789	denotes	ONL
T6834	14176-14184	_FRAGMENT	denotes	death of
T6835	14191-14196	GO:0008219	denotes	cells
T6836	14191-14196	CL_GO_EXT:cell	denotes	cells
T6837	14208-14215	_FRAGMENT	denotes	bipolar
T6838	14229-14236	CL:0000103	denotes	neurons
T6839	14220-14228	UBERON:0000045	denotes	ganglion
T6840	14220-14236	CL:0000740	denotes	ganglion neurons
T6841	14272-14281	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelling
T6842	14286-14295	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T6843	14300-14304	CL_GO_EXT:cell	denotes	cell
T6844	14319-14326	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T6845	14387-14389	PR_EXT:000013773	denotes	Rb
T6846	14393-14401	UBERON:0000045	denotes	ganglion
T6847	14393-14407	CL:0000740	denotes	ganglion cells
T6848	14402-14407	CL_GO_EXT:cell	denotes	cells
T6849	14445-14456	UBERON_EXT:optic_nerve	denotes	optic nerve
T6850	14494-14502	SO_EXT:sequence_deletion_process	denotes	Deleting
T6851	14503-14507	PR_EXT:000006852	denotes	E2f1
T6852	14517-14521	PR_EXT:000006853	denotes	E2f2
T6853	14525-14529	PR_EXT:000006854	denotes	E2f3
T6854	14552-14556	CL_GO_EXT:cell	denotes	cell
T6855	14552-14562	GO:0008219	denotes	cell death
T8946	16574-16589	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T8947	16597-16599	PR_EXT:000013773	denotes	Rb
T8948	16600-16604	PR_EXT:000006852	denotes	E2f1
T8949	16609-16615	UBERON:0000966	denotes	Retina
T8950	16624-16628	PR_EXT:000006852	denotes	E2f1
T8951	16629-16637	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T8952	16667-16672	GO:0016265	denotes	death
T8953	16680-16682	PR_EXT:000013773	denotes	Rb
T8954	16686-16692	UBERON:0000966	denotes	retina
T8955	16698-16700	PR_EXT:000013773	denotes	Rb
T8956	16701-16705	PR_EXT:000006852	denotes	E2f1
T8957	16710-16716	UBERON:0000966	denotes	retina
T8958	16767-16769	PR_EXT:000013773	denotes	Rb
T8959	16770-16778	GO:0065007	denotes	controls
T8960	16779-16794	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8961	16810-16814	CL_GO_EXT:cell	denotes	cell
T8962	16810-16820	GO:0007049	denotes	cell cycle
T8963	16834-16836	PR_EXT:000013773	denotes	Rb
T8964	16837-16841	PR_EXT:000006852	denotes	E2f1
T8965	16846-16852	UBERON:0000966	denotes	retina
T8966	16862-16865	PR_EXT:000014434	denotes	Sag
T8967	16868-16877	PR_EXT:000014434	denotes	S-antigen
T8968	16870-16877	CHEBI_EXT:59132	denotes	antigen
T8969	16878-16881	CL:0000604	denotes	rod
T8970	16878-16890	PR_EXT:000014434	denotes	rod arrestin
T8971	16892-16906	CL:0000210	denotes	photoreceptors
T8972	16908-16914	PR_EXT:000013042	denotes	Pou4f2
T8973	16917-16922	PR_EXT:000013042	denotes	Brn3b
T8974	16924-16932	UBERON:0000045	denotes	ganglion
T8975	16924-16938	CL:0000740	denotes	ganglion cells
T8976	16933-16938	CL_GO_EXT:cell	denotes	cells
T8977	16953-16958	PR_EXT:000003058	denotes	Prkca
T8978	16960-16965	PR_EXT:000004937	denotes	Cabp5
T8979	16967-16982	CL:0000103	denotes	bipolar neurons
T8980	17030-17036	SO_EXT:sequence_rescue_process	denotes	rescue
T8981	17040-17044	CL_GO_EXT:cell	denotes	cell
T8982	17054-17056	PR_EXT:000013773	denotes	Rb
T8983	17057-17061	PR_EXT:000006853	denotes	E2f2
T8984	17065-17067	PR_EXT:000013773	denotes	Rb
T8985	17068-17072	PR_EXT:000006854	denotes	E2f3
T8986	17077-17084	UBERON:0000966	denotes	retinas
T8987	17120-17128	CL:0000540	denotes	neuronal
T8988	17129-17136	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T8989	17137-17142	PR_EXT:000010124	denotes	Mtap2
T8990	17144-17148	PR_EXT:000010124	denotes	MAP2
T8991	17154-17160	PR_EXT:000015312	denotes	Snap25
T8992	17179-17186	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T8993	17187-17196	GO:0010467	denotes	expressed
T8994	17200-17213	CL:0000103	denotes	bipolar cells
T8995	17208-17213	CL_GO_EXT:cell	denotes	cells
T8996	17215-17220	PR_EXT:000017355	denotes	Chx10
T8997	17222-17227	PR_EXT:000013845	denotes	Rcvrn
T8998	17229-17233	PR_EXT:000017354	denotes	Vsx1
T8999	17235-17240	PR_EXT:000001242	denotes	Tacr3
T9000	17246-17252	PR_EXT:000004445	denotes	Atp2b1
T9001	17258-17276	CL:0000604	denotes	rod photoreceptors
T9002	17278-17281	PR_EXT:000001245	denotes	Rho
T9003	17286-17291	PR_EXT:000013845	denotes	Rcvrn
T9004	17303-17309	SO_EXT:sequence_rescue_process	denotes	rescue
T9005	17317-17319	PR_EXT:000013773	denotes	Rb
T9006	17320-17324	PR_EXT:000006852	denotes	E2f1
T9007	17329-17335	UBERON:0000966	denotes	retina
T9008	17358-17365	CL:0000540	denotes	neurons
T9009	17410-17412	SO_EXT:wild_type_entity_or_quality	denotes	WT
T9010	17413-17419	UBERON:0000966	denotes	retina
T9011	17421-17433	CL:0000103	denotes	Bipolar cell
T9012	17429-17440	GO:0044297	denotes	cell bodies
T9013	17461-17464	UBERON:0001791	denotes	INL
T9014	17498-17507	GO:0042995	denotes	processes
T9015	17578-17580	PR_EXT:000013773	denotes	Rb
T9016	17581-17585	PR_EXT:000006852	denotes	E2f1
T9017	17590-17596	UBERON:0000966	denotes	retina
T9018	17621-17624	UBERON:0001789	denotes	ONL
T9019	17662-17666	CL:0000604	denotes	rods
T9020	17683-17692	GO:0042995	denotes	processes
T9021	17725-17734	GO:0042995	denotes	processes
T9022	17754-17759	_FRAGMENT	denotes	inner
T9023	17770-17778	GO:0001917	denotes	segments
T9024	17764-17778	GO:0001750	denotes	outer segments
T9025	17814-17816	PR_EXT:000013773	denotes	Rb
T9026	17823-17831	GO:0065007	denotes	regulate
T9027	17832-17845	CL:0000210	denotes	photoreceptor
T9028	17846-17861	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9029	17880-17883	CL:0000604	denotes	rod
T9030	17893-17906	GO_EXT:transcription	denotes	transcription
T9031	17893-17914	GO_EXT:transcription_factor	denotes	transcription factors
T9032	17945-17947	PR_EXT:000013773	denotes	Rb
T9033	17953-17961	GO:0065007	denotes	regulate
T9034	17962-17975	CL:0000210	denotes	photoreceptor
T9035	17976-17991	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9036	18018-18022	PR_EXT:000006852	denotes	E2f1
T9037	18044-18047	CL:0000604	denotes	rod
T9038	18048-18063	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9039	18081-18085	PR_EXT:000012086	denotes	Otx2
T9040	18087-18090	PR_EXT:000005904	denotes	Crx
T9041	18095-18098	PR_EXT:000011432	denotes	Nrl
T9042	18133-18137	PR_EXT:000006852	denotes	E2f1
T9043	18147-18162	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9044	18190-18200	GO:0010467	denotes	expression
T9045	18204-18209	SO_EXT:0000704	denotes	genes
T9046	18215-18223	GO:0065007	denotes	modulate
T9047	18224-18234	GO_PATO_EXT:biological_maturation	denotes	maturation
T9048	18277-18290	GO:0008283	denotes	proliferation
T9049	18346-18355	GO:0006915	denotes	apoptosis
T9050	18380-18386	SO_EXT:sequence_rescue_process	denotes	rescue
T9051	18390-18392	PR_EXT:000013773	denotes	Rb
T9052	18396-18403	UBERON:0000966	denotes	retinal
T9053	18396-18411	_FRAGMENT	denotes	retinal bipolar
T9054	18431-18436	CL:0000748	denotes	cells
T9055	18396-18403	_FRAGMENT	denotes	retinal
T9056	18413-18421	_FRAGMENT	denotes	ganglion
T9057	18431-18436	CL:0000740	denotes	cells
T9058	18427-18436	CL:0000604	denotes	rod cells
T9059	18413-18421	UBERON:0000045	denotes	ganglion
T9060	18431-18436	CL_GO_EXT:cell	denotes	cells
T9061	18454-18458	PR_EXT:000006852	denotes	E2f1
T9062	18534-18536	PR_EXT:000013773	denotes	Rb
T9063	18546-18550	PR_EXT:000006852	denotes	E2f1
T9064	18572-18575	CL:0002672	denotes	RPC
T9065	18606-18609	CL:0002672	denotes	RPC
T9066	18610-18623	GO:0008283	denotes	proliferation
T9067	18700-18703	CL:0002672	denotes	RPC
T9068	18730-18734	PR_EXT:000006852	denotes	E2f1
T9069	18786-18794	UBERON:0000045	denotes	ganglion
T9070	18786-18800	CL:0000740	denotes	ganglion cells
T9071	18795-18800	CL_GO_EXT:cell	denotes	cells
T9072	18825-18838	CL:0000103	denotes	bipolar cells
T9073	18833-18838	CL_GO_EXT:cell	denotes	cells
T9074	18882-18885	UBERON:0001789	denotes	ONL
T9075	18907-18911	PR_EXT:000006852	denotes	E2f1
T9076	18919-18921	PR_EXT:000013773	denotes	Rb
T9077	18922-18926	PR_EXT:000006852	denotes	E2f1
T9078	18931-18937	UBERON:0000966	denotes	retina
T9079	18972-18976	PR_EXT:000006852	denotes	E2f1
T9080	18980-18987	CL:0000540	denotes	neurons
T9081	18992-18994	SO_EXT:wild_type_entity_or_quality	denotes	WT
T9082	19042-19046	CL_GO_EXT:cell	denotes	cell
T9083	19074-19076	PR_EXT:000013773	denotes	Rb
T9084	19077-19081	PR_EXT:000006852	denotes	E2f1
T9085	19090-19094	PR_EXT:000006852	denotes	E2f1
T9086	19098-19111	CL:0000103	denotes	bipolar cells
T9087	19106-19111	CL_GO_EXT:cell	denotes	cells
T9088	19128-19130	SO_EXT:wild_type_entity_or_quality	denotes	WT
T9089	19166-19170	CL_GO_EXT:cell	denotes	cell
T9090	19208-19213	GO:0016265	denotes	death
T9091	19249-19258	GO:0006915	denotes	apoptosis
T9092	19266-19275	_FRAGMENT	denotes	embryonic
T9093	19289-19294	UBERON_EXT:embryonic_stage_or_stage_part	denotes	stage
T9094	19283-19288	GO:0007567	denotes	natal
T9095	19313-19315	PR_EXT:000013773	denotes	Rb
T9096	19316-19320	PR_EXT:000006852	denotes	E2f1
T9097	19325-19331	UBERON:0000966	denotes	retina
T9098	19368-19376	SO_EXT:sequence_deletion_process	denotes	deleting
T9099	19377-19382	PR_EXT:000005121	denotes	Ccnd1
T9100	19407-19409	PR_EXT:000013773	denotes	Rb
T9101	19410-19418	CHEBI_PR_EXT:protein	denotes	proteins
T9102	19433-19436	CL:0002672	denotes	RPC
T9103	19485-19487	PR_EXT:000013773	denotes	Rb
T9104	19491-19497	UBERON:0000966	denotes	retina
T9105	19558-19561	CL:0002672	denotes	RPC
T9106	19584-19590	SO_EXT:sequence_rescue_process	denotes	rescue
T9107	19612-19614	PR_EXT:000013773	denotes	Rb
T9108	19662-19670	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T9109	19674-19678	PR_EXT:000006852	denotes	E2f1
T10899	19704-19706	PR_EXT:000013773	denotes	Rb
T10900	19707-19711	PR_EXT:000006852	denotes	E2f1
T10901	19716-19722	UBERON:0000966	denotes	Retina
T10902	19742-19746	PR_EXT:000006852	denotes	E2f1
T10903	19752-19759	SO_EXT:sequence_rescue_process	denotes	rescues
T10904	19783-19785	PR_EXT:000013773	denotes	Rb
T10905	19789-19796	CL:0000540	denotes	neurons
T10906	19819-19821	PR_EXT:000013773	denotes	Rb
T10907	19836-19844	GO:0065007	denotes	regulate
T10908	19845-19860	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T10909	19879-19882	PR_EXT:E2F	denotes	E2f
T10910	19976-19991	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T10911	20044-20049	UBERON:0007023	denotes	adult
T10912	20050-20052	SO_EXT:wild_type_entity_or_quality	denotes	WT
T10913	20062-20066	PR_EXT:000006852	denotes	E2f1
T10914	20066-20067	SO_EXT:sequence_nullness_or_absence	denotes	−
T10915	20068-20069	SO_EXT:sequence_nullness_or_absence	denotes	−
T10916	20077-20079	PR_EXT:000013773	denotes	Rb
T10917	20079-20083	SO_EXT:0000346	denotes	loxP
T10918	20084-20088	SO_EXT:0000346	denotes	loxP
T10919	20100-20102	PR_EXT:000013773	denotes	Rb
T10920	20102-20106	SO_EXT:0000346	denotes	loxP
T10921	20107-20111	SO_EXT:0000346	denotes	loxP
T10922	20112-20116	PR_EXT:000006852	denotes	E2f1
T10923	20116-20117	SO_EXT:sequence_nullness_or_absence	denotes	−
T10924	20118-20119	SO_EXT:sequence_nullness_or_absence	denotes	−
T10925	20120-20124	NCBITaxon:10088	denotes	mice
T10926	20151-20168	GO:0007602	denotes	visual signalling
T10927	20176-20185	NCBITaxon:40674	denotes	mammalian
T10928	20186-20192	UBERON:0000966	denotes	retina
T10929	20198-20212	CL:0000210	denotes	photoreceptors
T10930	20216-20230	CL:0000561	denotes	amacrine cells
T10931	20225-20230	CL_GO_EXT:cell	denotes	cells
T10932	20248-20255	UBERON:0000045	denotes	gangion
T10933	20248-20261	CL:0000740	denotes	gangion cells
T10934	20256-20261	CL_GO_EXT:cell	denotes	cells
T10935	20285-20288	_FRAGMENT	denotes	rod
T10936	20298-20311	CL:0000751	denotes	bipolar cells
T10937	20293-20311	CL:0000752	denotes	cone bipolar cells
T10938	20306-20311	CL_GO_EXT:cell	denotes	cells
T10939	20389-20403	CL:0000210	denotes	photoreceptors
T10940	20480-20493	_FRAGMENT	denotes	activation of
T10941	20505-20510	GO:0001775	denotes	cells
T10942	20494-20510	CL:0000749	denotes	ON bipolar cells
T10943	20505-20510	CL_GO_EXT:cell	denotes	cells
T10944	20525-20534	GO_EXT:reaction_or_response	denotes	Responses
T10945	20551-20563	GO:1990603	denotes	dark-adapted
T10946	20565-20573	GO:1990603	denotes	scotopic
T10947	20610-20613	CL:0000604	denotes	rod
T10948	20648-20650	PR_EXT:000013773	denotes	Rb
T10949	20654-20660	UBERON:0000966	denotes	retina
T10950	20742-20745	_FRAGMENT	denotes	rod
T10951	20758-20762	CL:0000604	denotes	cell
T10952	20763-20772	GO:0097473	denotes	apoptosis
T10953	20750-20762	CL:0000103	denotes	bipolar cell
T10954	20758-20762	CL_GO_EXT:cell	denotes	cell
T10955	20758-20772	GO:0006915	denotes	cell apoptosis
T10956	20810-20818	GO_EXT:reaction_or_response	denotes	response
T10957	20897-20903	UBERON:0000966	denotes	retina
T10958	20905-20914	GO_EXT:reaction_or_response	denotes	Responses
T10959	20942-20944	SO_EXT:wild_type_entity_or_quality	denotes	WT
T10960	20949-20953	PR_EXT:000006852	denotes	E2f1
T10961	20957-20963	UBERON:0000966	denotes	retina
T10962	20997-20999	PR_EXT:000013773	denotes	Rb
T10963	21000-21004	PR_EXT:000006852	denotes	E2f1
T10964	21009-21017	GO_EXT:reaction_or_response	denotes	response
T10965	21106-21110	PR_EXT:000006852	denotes	E2f1
T10966	21111-21119	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T10967	21138-21145	SO_EXT:sequence_rescue_process	denotes	rescued
T10968	21150-21153	CL:0000604	denotes	rod
T10969	21168-21170	PR_EXT:000013773	denotes	Rb
T10970	21174-21180	UBERON:0000966	denotes	retina
T10971	21182-21195	GO:0036367	denotes	Light-adapted
T10972	21197-21205	GO:0036367	denotes	photopic
T10973	21245-21249	CL:0000573	denotes	cone
T10974	21285-21290	CL:0000573	denotes	Cones
T10975	21312-21326	CL:0000210	denotes	photoreceptors
T10976	21339-21343	CL:0000604	denotes	rods
T10977	21361-21363	PR_EXT:000013773	denotes	Rb
T10978	21382-21386	CL:0000604	denotes	rods
T10979	21412-21414	PR_EXT:000013773	denotes	Rb
T10980	21418-21424	UBERON:0000966	denotes	retina
T10981	21466-21474	GO:0045202	denotes	synaptic
T10982	21484-21497	CL:0000103	denotes	bipolar cells
T10983	21492-21497	CL_GO_EXT:cell	denotes	cells
T10984	21526-21543	GO:0036367	denotes	photopic response
T10985	21558-21562	CL:0000573	denotes	cone
T10986	21574-21581	CL:0000103	denotes	bipolar
T10987	21612-21614	PR_EXT:000013773	denotes	Rb
T10988	21629-21636	SO_EXT:sequence_rescue_process	denotes	rescued
T10989	21657-21659	PR_EXT:000013773	denotes	Rb
T10990	21660-21664	PR_EXT:000006852	denotes	E2f1
T10991	21669-21675	UBERON:0000966	denotes	retina
T10992	21745-21749	PR_EXT:000006852	denotes	E2f1
T10993	21764-21781	GO:0036367	denotes	photopic response
T10994	21785-21789	PR_EXT:000006852	denotes	E2f1
T10995	21793-21797	NCBITaxon:10088	denotes	mice
T10996	21831-21833	SO_EXT:wild_type_entity_or_quality	denotes	WT
T10997	21865-21869	PR_EXT:000006852	denotes	E2f1
T10998	21907-21916	UBERON:0000922	denotes	embryonic
T10999	21917-21921	CL:0002672	denotes	RPCs
T11000	21931-21935	PR_EXT:000006852	denotes	E2f1
T11001	21939-21945	UBERON:0000966	denotes	retina
T11002	21984-21989	CL_GO_EXT:cell	denotes	cells
T11003	21999-22001	SO_EXT:wild_type_entity_or_quality	denotes	WT
T11004	22002-22008	UBERON:0000966	denotes	retina
T11005	22019-22023	CL_GO_EXT:cell	denotes	cell
T11006	22120-22138	GO:0036367	denotes	photopic responses
T11007	22146-22148	PR_EXT:000013773	denotes	Rb
T11008	22149-22153	PR_EXT:000006852	denotes	E2f1
T11009	22158-22164	UBERON:0000966	denotes	retina
T11010	22206-22210	CL:0000573	denotes	cone
T11011	22222-22226	PR_EXT:000006852	denotes	E2f1
T11012	22230-22234	NCBITaxon:10088	denotes	mice
T11013	22278-22282	CL:0000573	denotes	cone
T11014	22308-22310	PR_EXT:000013773	denotes	Rb
T11015	22328-22330	SO_EXT:wild_type_entity_or_quality	denotes	WT
T11016	22372-22387	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T11017	22410-22424	CL:0000561	denotes	amacrine cells
T11018	22419-22424	CL_GO_EXT:cell	denotes	cells
T11019	22500-22504	PR_EXT:000006852	denotes	E2f1
T11020	22505-22513	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T11021	22539-22547	GO_EXT:reaction_or_response	denotes	response
T11022	22555-22559	PR_EXT:000006852	denotes	E2f1
T11023	22560-22568	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T11024	22578-22585	SO_EXT:sequence_rescue_process	denotes	rescues
T11025	22611-22614	CL:0000604	denotes	rod
T11026	22619-22623	CL:0000573	denotes	cone
T11027	22647-22649	PR_EXT:000013773	denotes	Rb
T11028	22653-22659	UBERON:0000966	denotes	retina
T13557	22778-22790	CL:0000103	denotes	bipolar cell
T13558	22786-22790	CL_GO_EXT:cell	denotes	cell
T13559	22814-22829	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T13560	22847-22852	CL_GO_EXT:cell	denotes	cells
T13561	22900-22902	PR_EXT:000013773	denotes	Rb
T13562	22903-22907	PR_EXT:000006852	denotes	E2f1
T13563	22912-22918	UBERON:0000966	denotes	retina
T13564	22927-22934	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T13565	22958-22966	CHEBI_PR_EXT:protein	denotes	proteins
T13566	22999-23001	SO_EXT:wild_type_entity_or_quality	denotes	WT
T13567	23003-23007	PR_EXT:000006852	denotes	E2f1
T13600	24491-24492	UBERON:0000966	denotes	t
T13601	24495-24496	UBERON:0000966	denotes	t
T13602	24496-24497	GO_PR_EXT:choline_O_acetyltransferase	denotes	h
T13603	24501-24503	GO_PR_EXT:choline_O_acetyltransferase	denotes	Ca
T13604	24504-24506	PR_EXT:000004968	denotes	b2
T13605	24591-24605	GO:0097447	denotes	dendritic-tree
T13606	24637-24648	CHEBI:15355	denotes	cholinergic
T13607	24669-24685	CL:0000561	denotes	amacrine neurons
T13608	24808-24815	UBERON:0000966	denotes	retinal
T13609	24808-24827	GO:0060041	denotes	retinal development
T13610	24846-24849	UBERON:0001791	denotes	INL
T13611	24850-24857	GO:0045202	denotes	synapse
T13612	24891-24899	GO_EXT:reaction_or_response	denotes	responds
T13613	24949-24952	UBERON:0001792	denotes	GCL
T13614	24958-24967	GO:0042995	denotes	processes
T13615	25020-25028	GO_EXT:reaction_or_response	denotes	responds
T13616	25080-25089	GO:0042995	denotes	processes
T13617	25113-25120	PR_EXT:000014968	denotes	Slc18a3
T13618	25122-25131	GO:0031982	denotes	vesicular
T13619	25122-25158	PR_EXT:000014968	denotes	vesicular acetyl choline transporter
T13620	25132-25146	CHEBI:15355	denotes	acetyl choline
T13621	25147-25158	GO_EXT:biological_mover_or_transporter	denotes	transporter
T13622	25160-25165	PR_EXT:000014968	denotes	VAChT
T13623	25198-25204	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T13624	25223-25233	_FRAGMENT	denotes	peripheral
T13625	25259-25265	UBERON:0013682	denotes	retina
T13626	25234-25236	PR_EXT:000013773	denotes	Rb
T13627	25243-25245	PR_EXT:000013773	denotes	Rb
T13628	25246-25250	PR_EXT:000006852	denotes	E2f1
T13629	25288-25292	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T13630	25294-25303	GO:0010467	denotes	expressed
T13631	25351-25356	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marks
T13632	25362-25366	CL_GO_EXT:cell	denotes	cell
T13633	25362-25373	GO:0044297	denotes	cell bodies
T13634	25378-25387	GO:0042995	denotes	processes
T13635	25409-25413	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T13636	25432-25437	CL_GO_EXT:cell	denotes	cells
T13637	25452-25454	PR_EXT:000013773	denotes	Rb
T13638	25458-25464	UBERON:0000966	denotes	retina
T13639	25489-25493	GO:0044297	denotes	soma
T13640	25510-25519	GO:0042995	denotes	processes
T13641	25565-25569	PR_EXT:000015851	denotes	Sv2c
T13642	25573-25589	GO:0008021	denotes	synaptic vesicle
T13643	25590-25597	CHEBI_PR_EXT:protein	denotes	protein
T13644	25618-25624	PR_EXT:000000940	denotes	Kcnc1b
T13645	25629-25634	PR_EXT:000000782	denotes	Kcnc2
T13646	25636-25645	CHEBI_EXT:potassium	denotes	potassium
T13647	25636-25654	GO_EXT:0005267	denotes	potassium channels
T13648	25655-25664	GO:0010467	denotes	expressed
T13649	25672-25676	GO:0044297	denotes	soma
T13650	25681-25690	GO:0030425	denotes	dendrites
T13651	25725-25733	UBERON:0000045	denotes	ganglion
T13652	25725-25739	CL:0000740	denotes	ganglion cells
T13653	25734-25739	CL_GO_EXT:cell	denotes	cells
T13654	25746-25769	CHEBI:16865	denotes	gamma-aminobutyric acid
T13655	25771-25775	CHEBI:16865	denotes	GABA
T13656	25792-25808	CHEBI_EXT:25512	denotes	neurotransmitter
T13657	25834-25848	CL:0000561	denotes	amacrine cells
T13658	25843-25848	CL_GO_EXT:cell	denotes	cells
T13659	25876-25886	_FRAGMENT	denotes	horizontal
T13660	25904-25911	CL:0000745	denotes	neurons
T13661	25896-25911	CL:0000103	denotes	bipolar neurons
T13662	25922-25927	PR_EXT:000004967	denotes	Calb1
T13663	25929-25938	PR_EXT:000004967	denotes	calbindin
T13664	25950-25959	GO:0010467	denotes	expressed
T13665	25968-25982	CL:0000561	denotes	amacrine cells
T13666	25977-25982	CL_GO_EXT:cell	denotes	cells
T13667	25987-25993	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labels
T13668	25998-26005	GO:0042995	denotes	process
T13669	26106-26108	PR_EXT:000013773	denotes	Rb
T13670	26109-26117	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T13671	26125-26140	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T13672	26149-26154	PR_EXT:000017355	denotes	Chx10
T13673	26159-26168	SO_EXT:0000902	denotes	transgene
T13674	26177-26186	GO:0010467	denotes	expressed
T13675	26218-26224	UBERON:0000966	denotes	retina
T13676	26252-26262	GO:0010467	denotes	expressing
T13677	26263-26268	CL_GO_EXT:cell	denotes	cells
T13678	26302-26310	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T13679	26349-26353	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T13680	26354-26361	PR_EXT:000014968	denotes	Slc18a3
T13681	26385-26390	PR_EXT:000017355	denotes	Chx10
T13682	26395-26397	PR_EXT:000013773	denotes	Rb
T13683	26397-26401	SO_EXT:0000346	denotes	loxP
T13684	26402-26406	SO_EXT:0000346	denotes	loxP
T13685	26407-26413	UBERON:0000966	denotes	retina
T13686	26426-26428	SO_EXT:wild_type_entity_or_quality	denotes	WT
T13687	26486-26488	PR_EXT:000013773	denotes	Rb
T13688	26496-26511	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T13689	26630-26637	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T13690	26655-26661	PR_EXT:000003199	denotes	Camk2a
T13691	26662-26667	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marks
T13692	26682-26690	UBERON:0000045	denotes	ganglion
T13693	26682-26696	CL:0000740	denotes	ganglion cells
T13694	26691-26696	CL_GO_EXT:cell	denotes	cells
T13695	26715-26723	UBERON:0000045	denotes	ganglion
T13696	26715-26729	CL:0000740	denotes	ganglion cells
T13697	26724-26729	CL_GO_EXT:cell	denotes	cells
T13698	26734-26744	GO_EXT:killing	denotes	eliminated
T13699	26752-26754	PR_EXT:000013773	denotes	Rb
T13700	26758-26764	UBERON:0000966	denotes	retina
T13701	26766-26772	PR_EXT:000003199	denotes	Camk2a
T13702	26791-26797	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T13703	26828-26834	PR_EXT:000003199	denotes	Camk2a
T13704	26847-26856	GO:0030425	denotes	dendrites
T13705	26882-26884	SO_EXT:wild_type_entity_or_quality	denotes	WT
T13706	26889-26891	PR_EXT:000013773	denotes	Rb
T13707	26895-26901	UBERON:0000966	denotes	retina
T13708	26933-26939	PR_EXT:000003199	denotes	Camk2a
T13709	26941-26945	GO:0044297	denotes	soma
T13710	26961-26963	SO_EXT:wild_type_entity_or_quality	denotes	WT
T13711	26968-26970	PR_EXT:000013773	denotes	Rb
T13712	26974-26980	UBERON:0000966	denotes	retina
T13713	27015-27020	CL_GO_EXT:cell	denotes	cells
T13714	27032-27034	PR_EXT:000013773	denotes	Rb
T13715	27038-27044	UBERON:0000966	denotes	retina
T13716	27118-27120	PR_EXT:000013773	denotes	Rb
T13717	27161-27168	GO:0042995	denotes	process
T13718	27203-27211	GO:0065007	denotes	regulate
T13719	27216-27226	GO:0010467	denotes	expression
T13720	27247-27252	PR_EXT:000004968	denotes	Calb2
T13721	27254-27259	PR_EXT:000004967	denotes	Calb1
T13722	27261-27265	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T13723	27267-27274	PR_EXT:000014968	denotes	Slc18a3
T13724	27276-27280	PR_EXT:000015851	denotes	Sv2c
T13725	27282-27288	PR_EXT:000000940	denotes	Kcnc1b
T13726	27290-27295	PR_EXT:000000782	denotes	Kcnc2
T13727	27301-27305	CHEBI:16865	denotes	GABA
T13728	27326-27332	PR_EXT:000003199	denotes	Camk2a
T13729	27333-27343	GO:0010467	denotes	expression
T13730	27382-27386	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T13731	27395-27399	CL_GO_EXT:cell	denotes	cell
T13732	27395-27406	GO:0044297	denotes	cell bodies
T13733	27420-27429	GO:0042995	denotes	processes
T13734	27505-27512	PR_EXT:000014968	denotes	Slc18a3
T13735	27513-27523	GO:0010467	denotes	expression
T13736	27562-27564	SO_EXT:wild_type_entity_or_quality	denotes	WT
T13737	27570-27577	PR_EXT:000014968	denotes	Slc18a3
T13738	27589-27598	GO:0042995	denotes	processes
T13739	27617-27622	GO:0007567	denotes	natal
T13740	27648-27652	CL_GO_EXT:cell	denotes	cell
T13741	27648-27657	GO:0044297	denotes	cell body
T13742	27663-27668	GO_EXT:biological_movement_or_translocation_process	denotes	moves
T13743	27683-27692	GO:0042995	denotes	processes
T13744	27733-27740	PR_EXT:000014968	denotes	Slc18a3
T13745	27766-27768	PR_EXT:000013773	denotes	Rb
T13746	27772-27778	UBERON:0000966	denotes	retina
T13747	27814-27818	CL_GO_EXT:cell	denotes	cell
T13748	27814-27825	GO:0044297	denotes	cell bodies
T13749	27853-27855	PR_EXT:000013773	denotes	Rb
T13750	27859-27868	GO:0042995	denotes	processes
T13751	27890-27897	PR_EXT:000014968	denotes	Slc18a3
T13752	27931-27933	PR_EXT:000013773	denotes	Rb
T13753	27994-27996	PR_EXT:000013773	denotes	Rb
T13754	28055-28062	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T16228	29528-29530	PR_EXT:000013773	denotes	Rb
T16229	29531-29540	GO:0065007	denotes	Regulates
T16230	29545-29560	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T16231	29569-29573	PR_EXT:000006854	denotes	E2f3
T16232	29574-29576	PR_EXT:000013773	denotes	Rb
T16233	29577-29582	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T16234	29597-29605	CHEBI_PR_EXT:protein	denotes	proteins
T16235	29627-29635	CL:0000540	denotes	neuronal
T16236	29636-29641	CL_GO_EXT:cell	denotes	cells
T16237	29651-29666	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T16238	29668-29678	CL:0000136	denotes	adipocytes
T16239	29684-29688	UBERON_EXT:bone_element_or_tissue	denotes	bone
T16240	29690-29692	PR_EXT:000013773	denotes	Rb
T16241	29707-29711	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T16242	29727-29733	UBERON:0000479	denotes	tissue
T16243	29743-29756	GO_EXT:transcription	denotes	transcription
T16244	29743-29764	GO_EXT:transcription_factor	denotes	transcription factors
T16245	29778-29793	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T16246	29826-29828	PR_EXT:000013773	denotes	Rb
T16247	29849-29855	UBERON:0000966	denotes	retina
T16248	29891-29906	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T16249	29926-29929	PR_EXT:E2F	denotes	E2f
T16250	29943-29945	PR_EXT:000013773	denotes	Rb
T16251	29956-29971	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T16252	29996-30000	CL_GO_EXT:cell	denotes	cell
T16253	29996-30006	GO:0007049	denotes	cell cycle
T16254	29996-30000	_FRAGMENT	denotes	cell
T16255	30010-30015	GO:0008219	denotes	death
T16256	30078-30081	PR_EXT:E2F	denotes	E2f
T16257	30086-30094	GO:0065007	denotes	regulate
T16258	30100-30115	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T16259	30116-30121	SO_EXT:0000704	denotes	genes
T16260	30155-30159	PR_EXT:000006853	denotes	E2f2
T16261	30163-30167	PR_EXT:000006854	denotes	E2f3
T16262	30182-30184	PR_EXT:000013773	denotes	Rb
T16263	30192-30202	GO_PATO_EXT:biological_maturation	denotes	maturation
T16264	30229-30233	PR_EXT:000006852	denotes	E2f1
T16265	30234-30242	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T16266	30262-30269	GO:0007067	denotes	mitosis
T16267	30276-30281	CL_GO_EXT:cell	denotes	cells
T16268	30324-30328	PR_EXT:000006853	denotes	E2f2
T16269	30329-30337	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T16270	30403-30407	PR_EXT:000006854	denotes	E2f3
T16271	30408-30416	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T16272	30441-30448	GO:0007067	denotes	mitosis
T16273	30453-30460	SO_EXT:sequence_rescue_process	denotes	rescued
T16274	30461-30466	PR_EXT:000004968	denotes	Calb2
T16275	30468-30475	PR_EXT:000014968	denotes	Slc18a3
T16276	30477-30481	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T16277	30483-30487	CHEBI:16865	denotes	GABA
T16278	30489-30495	PR_EXT:000000940	denotes	Kcnc1b
T16279	30497-30502	PR_EXT:000000782	denotes	Kcnc2
T16280	30508-30512	PR_EXT:000015851	denotes	Sv2c
T16281	30572-30574	PR_EXT:000013773	denotes	Rb
T16282	30575-30579	PR_EXT:000006854	denotes	E2f3
T16283	30633-30635	SO_EXT:wild_type_entity_or_quality	denotes	WT
T16284	30636-30642	UBERON:0000966	denotes	retina
T16285	30682-30690	GO:0045202	denotes	synaptic
T16286	30699-30704	CL_GO_EXT:cell	denotes	cells
T16287	30716-30722	GO_EXT:killing	denotes	killed
T16288	30726-30730	PR_EXT:000006852	denotes	E2f1
T16289	30762-30769	SO_EXT:sequence_rescue_process	denotes	rescued
T16290	30777-30779	PR_EXT:000013773	denotes	Rb
T16291	30780-30784	PR_EXT:000006852	denotes	E2f1
T16292	30785-30789	PR_EXT:000006854	denotes	E2f3
T16293	30806-30812	UBERON:0000966	denotes	retina
T16294	30820-30827	_FRAGMENT	denotes	bipolar
T16295	30841-30845	CL:0000103	denotes	cell
T16296	30832-30840	UBERON:0000045	denotes	ganglion
T16297	30832-30845	CL:0000740	denotes	ganglion cell
T16298	30841-30845	CL_GO_EXT:cell	denotes	cell
T16299	30841-30851	GO:0008219	denotes	cell death
T16300	30856-30863	SO_EXT:sequence_rescue_process	denotes	rescued
T16301	30872-30887	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T16302	30914-30918	PR_EXT:000006854	denotes	E2f3
T16303	30919-30927	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T16304	30953-30968	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T16305	31004-31008	PR_EXT:000006854	denotes	E2f3
T16306	31065-31067	PR_EXT:000013773	denotes	Rb
T16307	31082-31086	PR_EXT:000006854	denotes	E2f3
T16308	31118-31124	PR_EXT:000003199	denotes	Camk2a
T16309	31144-31153	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T16310	31176-31178	SO_EXT:wild_type_entity_or_quality	denotes	WT
T16311	31183-31189	PR_EXT:000003199	denotes	Camk2a
T16312	31191-31196	CL_GO_EXT:cell	denotes	cells
T16313	31197-31206	GO:0010467	denotes	expressed
T16314	31207-31211	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T16315	31216-31223	PR_EXT:000014968	denotes	Slc18a3
T16316	31259-31261	PR_EXT:000013773	denotes	Rb
T16317	31265-31271	UBERON:0000966	denotes	retina
T16318	31305-31307	PR_EXT:000013773	denotes	Rb
T16319	31308-31312	PR_EXT:000006852	denotes	E2f1
T16320	31317-31323	UBERON:0000966	denotes	retina
T16321	31348-31350	PR_EXT:000013773	denotes	Rb
T16322	31351-31355	PR_EXT:000006854	denotes	E2f3
T16323	31360-31366	UBERON:0000966	denotes	retina
T16324	31415-31417	SO_EXT:wild_type_entity_or_quality	denotes	WT
T16325	31426-31434	UBERON:0000045	denotes	ganglion
T16326	31426-31440	CL:0000740	denotes	ganglion cells
T16327	31435-31440	CL_GO_EXT:cell	denotes	cells
T16328	31473-31479	PR_EXT:000003199	denotes	Camk2a
T16329	31481-31486	CL_GO_EXT:cell	denotes	cells
T16330	31492-31498	GO_EXT:killing	denotes	killed
T16331	31502-31511	GO:0006915	denotes	apoptosis
T16332	31549-31553	PR_EXT:E2F	denotes	E2fs
T16333	31609-31613	PR_EXT:000009116	denotes	Isl1
T16334	31615-31621	PR_EXT:000009116	denotes	Islet1
T16335	31629-31635	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T16336	31639-31648	GO:0010467	denotes	expressed
T16337	31666-31674	UBERON:0000045	denotes	ganglion
T16338	31666-31680	CL:0000740	denotes	ganglion cells
T16339	31675-31680	CL_GO_EXT:cell	denotes	cells
T16340	31687-31691	PR_EXT:000009116	denotes	Isl1
T16341	31693-31698	CL_GO_EXT:cell	denotes	cells
T16342	31706-31709	UBERON:0001791	denotes	INL
T16343	31767-31771	PR_EXT:000009116	denotes	Isl1
T16344	31773-31778	CL_GO_EXT:cell	denotes	cells
T16345	31800-31803	UBERON:0001791	denotes	INL
T16346	31820-31827	PR_EXT:000014968	denotes	Slc18a3
T16347	31846-31850	PR_EXT:000009116	denotes	Isl1
T16348	31871-31877	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T16349	31901-31905	PR_EXT:000009116	denotes	Isl1
T16350	31914-31921	PR_EXT:000014968	denotes	Slc18a3
T16351	31926-31933	GO:0005634	denotes	nuclear
T16352	31964-31968	PR_EXT:000009116	denotes	Isl1
T16353	31970-31975	PR_EXT:000010425	denotes	Mki67
T16354	31977-31982	CL_GO_EXT:cell	denotes	cells
T16355	31995-32004	GO:0010467	denotes	expressed
T16356	32018-32025	PR_EXT:000014968	denotes	Slc18a3
T16357	32108-32114	UBERON:0000966	denotes	retina
T16358	32172-32178	UBERON:0000966	denotes	retina
T16359	32192-32194	PR_EXT:000013773	denotes	Rb
T16360	32207-32211	CL_GO_EXT:cell	denotes	cell
T16361	32207-32217	GO:0007049	denotes	cell cycle
T16362	32248-32263	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T16363	32279-32281	SO_EXT:wild_type_entity_or_quality	denotes	WT
T16364	32282-32286	PR_EXT:000009116	denotes	Isl1
T16365	32288-32293	CL_GO_EXT:cell	denotes	cells
T16366	32307-32319	CL:0000031	denotes	neuroblastic
T16367	32353-32356	UBERON:0001791	denotes	INL
T16368	32385-32389	PR_EXT:000009116	denotes	Isl1
T16369	32391-32396	PR_EXT:000010425	denotes	Mki67
T16370	32398-32403	CL_GO_EXT:cell	denotes	cells
T16371	32425-32427	PR_EXT:000013773	denotes	Rb
T16372	32485-32489	PR_EXT:000009116	denotes	Isl1
T16373	32491-32496	CL_GO_EXT:cell	denotes	cells
T16374	32542-32544	PR_EXT:000013773	denotes	Rb
T16375	32548-32554	UBERON:0000966	denotes	retina
T16376	32594-32603	GO:0010467	denotes	expressed
T16377	32670-32672	PR_EXT:000013773	denotes	Rb
T16378	32673-32677	PR_EXT:000006852	denotes	E2f1
T16379	32682-32688	UBERON:0000966	denotes	retina
T16380	32745-32747	PR_EXT:000013773	denotes	Rb
T16381	32748-32752	PR_EXT:000006854	denotes	E2f3
T16382	32757-32763	UBERON:0000966	denotes	retina
T16383	32862-32867	PR_EXT:000004968	denotes	Calb2
T16384	32875-32880	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marks
T16385	32904-32918	CL:0000561	denotes	amacrine cells
T16386	32913-32918	CL_GO_EXT:cell	denotes	cells
T16387	32946-32948	PR_EXT:000013773	denotes	Rb
T16388	32958-32962	PR_EXT:000006852	denotes	E2f1
T16389	32963-32971	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T16390	33017-33032	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T16391	33042-33046	PR_EXT:000006854	denotes	E2f3
T16392	33047-33055	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T16393	33076-33091	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T18253	33270-33277	UBERON:0000966	denotes	retinal
T18255	33302-33306	CL_GO_EXT:cell	denotes	cell
T18274	33876-33880	PR_EXT:000006854	denotes	E2f3
T18275	33882-33887	CL_GO_EXT:cell	denotes	cells
T18276	33968-33975	GO:0007067	denotes	mitotic
T18277	33976-33981	CL_GO_EXT:cell	denotes	cells
T18278	33995-34001	UBERON:0000966	denotes	retina
T18279	34002-34011	GO:0010467	denotes	expressed
T18280	34012-34016	PR_EXT:000006854	denotes	E2f3
T18281	34038-34042	PR_EXT:000006854	denotes	E2f3
T18282	34125-34132	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T18283	34141-34145	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T18284	34150-34157	PR_EXT:000014968	denotes	Slc18a3
T18285	34187-34198	GO:0005737	denotes	cytoplasmic
T18286	34199-34203	PR_EXT:000006854	denotes	E2f3
T18287	34256-34260	PR_EXT:000006854	denotes	E2f3
T18288	34264-34281	UBERON:0013682	denotes	peripheral retina
T18289	34291-34295	PR_EXT:000006854	denotes	E2f3
T18290	34295-34299	SO_EXT:0000346	denotes	loxP
T18291	34300-34304	SO_EXT:0000346	denotes	loxP
T18292	34305-34309	NCBITaxon:10088	denotes	mice
T18293	34338-34347	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelling
T18294	34353-34357	PR_EXT:000006854	denotes	E2f3
T18295	34368-34372	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T18296	34378-34385	PR_EXT:000014968	denotes	Slc18a3
T18297	34409-34413	PR_EXT:000006854	denotes	E2f3
T18298	34437-34441	GO:0044297	denotes	soma
T18299	34446-34455	GO:0030425	denotes	dendrites
T18300	34469-34471	PR_EXT:000013773	denotes	Rb
T18301	34472-34479	CHEBI_PR_EXT:protein	denotes	protein
T18302	34511-34517	UBERON:0000966	denotes	retina
T18303	34568-34572	PR_EXT:000006854	denotes	E2f3
T18304	34625-34633	UBERON:0000045	denotes	ganglion
T18305	34625-34639	CL:0000740	denotes	ganglion cells
T18306	34634-34639	CL_GO_EXT:cell	denotes	cells
T18307	34644-34656	CL:0011107	denotes	Müller cells
T18308	34651-34656	CL_GO_EXT:cell	denotes	cells
T18309	34675-34677	PR_EXT:000013773	denotes	Rb
T18310	34694-34703	GO:0042995	denotes	processes
T18311	34741-34758	UBERON:0013682	denotes	peripheral retina
T18312	34767-34769	PR_EXT:000013773	denotes	Rb
T18313	34769-34773	SO_EXT:0000346	denotes	loxP
T18314	34774-34778	SO_EXT:0000346	denotes	loxP
T18315	34779-34783	NCBITaxon:10088	denotes	mice
T18316	34821-34823	PR_EXT:000013773	denotes	Rb
T18317	34828-34832	PR_EXT:000006854	denotes	E2f3
T18318	34835-34843	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localize
T18319	34861-34865	PR_EXT:000006854	denotes	E2f3
T18320	34890-34905	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T18321	34933-34942	GO:0010467	denotes	expressed
T18322	34952-34959	UBERON:0000966	denotes	retinal
T18323	34960-34967	CL:0000540	denotes	neurons
T18344	36160-36167	PR_EXT:000014968	denotes	Slc18a3
T18345	36169-36180	CHEBI:15355	denotes	cholinergic
T18346	36169-36188	CL:0000108	denotes	cholinergic neurons
T18347	36208-36218	_FRAGMENT	denotes	regions of
T18348	36223-36228	UBERON:0002616	denotes	brain
T18349	36233-36244	UBERON:0001948	denotes	spinal cord
T18350	36308-36319	CHEBI:15355	denotes	cholinergic
T18351	36308-36319	_FRAGMENT	denotes	cholinergic
T18352	36326-36333	CL:0000108	denotes	neurons
T18353	36320-36322	PR_EXT:000013773	denotes	Rb
T18354	36352-36361	UBERON:0001890	denotes	forebrain
T18355	36373-36375	PR_EXT:000013773	denotes	Rb
T18356	36379-36386	CL:0000540	denotes	neurons
T18357	36409-36424	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T18358	36443-36450	SO_EXT:sequence_rescue_process	denotes	rescued
T18359	36454-36462	SO_EXT:sequence_deletion_process	denotes	deleting
T18360	36463-36467	PR_EXT:000006854	denotes	E2f3
T18361	36541-36543	PR_EXT:000013773	denotes	Rb
T18362	36553-36559	UBERON_EXT:neural_tissue_or_nerve_or_nervous_system	denotes	neural
T18363	36560-36575	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T18364	36587-36591	PR_EXT:000006854	denotes	E2f3
T20106	36614-36626	GO_PATO_EXT:biological_localization_process_or_quality	denotes	Localization
T20107	36630-36634	PR_EXT:000006854	denotes	E2f3
T20108	36635-36643	SO_EXT:0001060	denotes	Isoforms
T20109	36660-36664	PR_EXT:000006854	denotes	E2f3
T20110	36669-36671	PR_EXT:000013773	denotes	Rb
T20111	36698-36705	GO:0005634	denotes	nuclear
T20112	36710-36721	GO:0005737	denotes	cytoplasmic
T20113	36746-36754	GO:0042571	denotes	antibody
T20114	36798-36808	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T20115	36851-36859	SO_EXT:0001060	denotes	isoforms
T20116	36883-36894	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T20117	36886-36894	CL_GO_EXT:cell	denotes	cellular
T20118	36907-36911	PR_EXT:000006854	denotes	E2f3
T20119	36912-36920	SO_EXT:0001060	denotes	isoforms
T20120	36952-36956	CL_GO_EXT:cell	denotes	cell
T20121	36995-36999	PR_EXT:000006854	denotes	E2f3
T20122	37023-37031	SO_EXT:0001060	denotes	isoforms
T20123	37048-37054	UBERON:0000966	denotes	retina
T20124	37068-37075	GO:0005634	denotes	nuclear
T20125	37080-37091	GO:0005737	denotes	cytoplasmic
T20126	37179-37183	PR_EXT:000006854	denotes	E2f3
T20127	37184-37192	GO:0042571	denotes	antibody
T20128	37245-37250	PR_EXT:000028775	denotes	E2f3a
T20129	37277-37288	CHEBI_SO_EXT:polypeptide	denotes	polypeptide
T20130	37342-37349	UBERON:0000966	denotes	retinal
T20131	37362-37367	PR_EXT:000028775	denotes	E2f3a
T20132	37388-37392	NCBITaxon:10088	denotes	mice
T20133	37403-37407	PR_EXT:000006854	denotes	E2f3
T20134	37408-37412	SO_EXT:0000147	denotes	exon
T20135	37425-37432	GO:0010467	denotes	express
T20136	37632-37637	PR_EXT:000028775	denotes	E2f3a
T20137	37637-37638	SO_EXT:sequence_nullness_or_absence	denotes	−
T20138	37639-37640	SO_EXT:sequence_nullness_or_absence	denotes	−
T20139	37641-37645	NCBITaxon:10088	denotes	mice
T20140	37694-37698	PR_EXT:000006854	denotes	E2f3
T20202	41306-41309	PR_EXT:E2F	denotes	E2f
T20203	41310-41322	GO:0046983	denotes	dimerization
T20204	41332-41337	PR_EXT:000016269	denotes	Tfdp1
T20205	41353-41360	GO:0005634	denotes	nuclear
T20206	41353-41380	SO_EXT:0001528	denotes	nuclear localization signal
T20207	41361-41373	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T20208	41401-41412	GO:0005737	denotes	cytoplasmic
T20209	41441-41455	CHEBI_GO_EXT:cyclin_dependent_kinase_inhibitor	denotes	Cdk inhibitors
T20210	41456-41462	PR_EXT:000005274	denotes	Cdkn1a
T20211	41467-41473	PR_EXT:000003090	denotes	Cdkn1b
T20212	41543-41547	CL_GO_EXT:cell	denotes	cell
T20213	41543-41553	GO:0007049	denotes	cell cycle
T20214	41554-41564	GO_EXT:regulator	denotes	regulators
T20215	41649-41656	GO:0005634	denotes	nuclear
T21433	41951-41972	GO_EXT:0003964	denotes	Reverse transcriptase
T21417	41680-41682	PR_EXT:000013773	denotes	Rb
T21419	41697-41712	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T21420	41721-41726	PR_EXT:000028775	denotes	E2f3a
T21421	41741-41745	PR_EXT:000006854	denotes	E2f3
T21422	41746-41753	SO_EXT:0001060	denotes	isoform
T21423	41782-41784	PR_EXT:000013773	denotes	Rb
T21424	41792-41807	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T21425	41821-41826	PR_EXT:000028775	denotes	E2f3a
T21426	41826-41827	SO_EXT:sequence_nullness_or_absence	denotes	−
T21427	41828-41829	SO_EXT:sequence_nullness_or_absence	denotes	−
T21428	41830-41834	NCBITaxon:10088	denotes	mice
T21429	41922-41927	PR_EXT:000028775	denotes	E2f3a
T21430	41929-41931	SO_EXT:wild_type_entity_or_quality	denotes	WT
T21431	41937-41941	SO_EXT:sequence_nullness	denotes	null
T21432	41942-41949	SO_EXT:0001023	denotes	alleles
T21434	41978-41980	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T21435	42017-42022	PR_EXT:000028775	denotes	E2f3a
T21436	42033-42036	CHEBI_SO_EXT:RNA	denotes	RNA
T21437	42063-42065	SO_EXT:wild_type_entity_or_quality	denotes	WT
T21438	42066-42072	UBERON:0000966	denotes	retina
T21439	42102-42107	PR_EXT:000028775	denotes	E2f3a
T21440	42108-42111	CHEBI_SO_EXT:RNA	denotes	RNA
T21441	42119-42124	PR_EXT:000028775	denotes	E2f3a
T21442	42124-42125	SO_EXT:sequence_nullness_or_absence	denotes	−
T21443	42126-42127	SO_EXT:sequence_nullness_or_absence	denotes	−
T21444	42128-42134	UBERON:0000966	denotes	retina
T21445	42148-42153	PR_EXT:000028775	denotes	E2f3a
T21446	42154-42161	CHEBI_PR_EXT:protein	denotes	protein
T21447	42176-42181	PR_EXT:000028775	denotes	E2f3a
T21448	42181-42182	SO_EXT:sequence_nullness_or_absence	denotes	−
T21449	42183-42184	SO_EXT:sequence_nullness_or_absence	denotes	−
T21450	42185-42192	UBERON:0000966	denotes	retinal
T21451	42253-42260	SO_EXT:0000673	denotes	message
T21452	42253-42260	CHEBI:33695	denotes	message
T21453	42281-42283	PR_EXT:000013773	denotes	Rb
T21454	42291-42293	PR_EXT:000013773	denotes	Rb
T21455	42294-42299	PR_EXT:000028775	denotes	E2f3a
T21456	42304-42310	UBERON:0000966	denotes	retina
T21457	42359-42364	PR_EXT:000028775	denotes	E2f3a
T21458	42365-42373	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T21459	42403-42418	GO_EXT:negative_regulation	denotes	down-regulation
T21460	42467-42471	PR_EXT:E2F	denotes	E2fs
T21461	42493-42495	PR_EXT:000013773	denotes	Rb
T21462	42500-42502	PR_EXT:000013773	denotes	Rb
T21463	42503-42507	PR_EXT:000006854	denotes	E2f3
T21464	42517-42519	PR_EXT:000013773	denotes	Rb
T21465	42520-42525	PR_EXT:000028775	denotes	E2f3a
T21466	42530-42536	UBERON:0000966	denotes	retina
T21467	42559-42569	GO:0065007	denotes	regulatory
T21468	42596-42601	PR_EXT:000028775	denotes	E2f3a
T21469	42614-42618	CL_GO_EXT:cell	denotes	cell
T21470	42614-42624	GO:0007049	denotes	cell cycle
T21471	42678-42682	CL_GO_EXT:cell	denotes	cell
T21472	42678-42688	GO:0007049	denotes	cell cycle
T21473	42783-42785	PR_EXT:000013773	denotes	Rb
T21474	42789-42798	GO:0044838	denotes	quiescent
T21475	42799-42804	CL_GO_EXT:cell	denotes	cells
T21476	42850-42865	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T21477	42869-42871	PR_EXT:000013773	denotes	Rb
T21478	42904-42909	PR_EXT:000028775	denotes	E2f3a
T21479	42910-42918	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T21480	42934-42936	PR_EXT:000013773	denotes	Rb
T21481	42996-43000	CL_GO_EXT:cell	denotes	cell
T21482	42996-43014	GO:0051726	denotes	cell cycle control
T21483	43016-43018	PR_EXT:000013773	denotes	Rb
T21484	43019-43029	GO:0065007	denotes	regulation
T21485	43033-43038	PR_EXT:000028775	denotes	E2f3a
T21486	43068-43076	CL:0000540	denotes	neuronal
T21487	43077-43092	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22868	43107-43109	PR_EXT:000013773	denotes	Rb
T22869	43110-43118	GO:0065007	denotes	Controls
T22870	43119-43126	UBERON:0000966	denotes	Retinal
T22871	43119-43131	CL:0009004	denotes	Retinal Cell
T22872	43127-43131	CL_GO_EXT:cell	denotes	Cell
T22873	43127-43140	GO:0051301	denotes	Cell Division
T22874	43127-43131	_FRAGMENT	denotes	Cell
T22875	43145-43150	GO:0008219	denotes	Death
T22876	43159-43163	PR_EXT:000006852	denotes	E2f1
T22877	43200-43202	PR_EXT:000013773	denotes	Rb
T22878	43228-43236	CL:0000540	denotes	neuronal
T22879	43237-43241	CL_GO_EXT:cell	denotes	cell
T22880	43237-43247	GO:0007049	denotes	cell cycle
T22881	43268-43283	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22882	43305-43310	GO:0016265	denotes	death
T22883	43368-43377	UBERON:0001987	denotes	placental
T22884	43449-43451	PR_EXT:000013773	denotes	Rb
T22885	43474-43478	CL_GO_EXT:cell	denotes	cell
T22886	43474-43484	GO:0007049	denotes	cell cycle
T22887	43501-43508	CL:0000540	denotes	neurons
T22888	43554-43561	CL:0000540	denotes	neurons
T22889	43583-43589	UBERON:0000966	denotes	retina
T22890	43626-43628	PR_EXT:000013773	denotes	Rb
T22891	43634-43643	GO:0065007	denotes	regulates
T22892	43644-43659	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22893	43728-43733	GO:0016265	denotes	death
T22894	43770-43772	PR_EXT:000013773	denotes	Rb
T22895	43777-43785	GO:0065007	denotes	regulate
T22896	43786-43794	CL:0000540	denotes	neuronal
T22897	43786-43805	GO:0042551	denotes	neuronal maturation
T22898	43837-43845	SO_EXT:sequence_deletion_process	denotes	deleting
T22899	43846-43850	PR_EXT:000006852	denotes	E2f1
T22900	43864-43871	SO_EXT:sequence_rescue_process	denotes	rescued
T22901	43893-43898	GO:0016265	denotes	death
T22902	43906-43908	PR_EXT:000013773	denotes	Rb
T22903	43912-43918	UBERON:0000966	denotes	retina
T22904	43939-43941	PR_EXT:000013773	denotes	Rb
T22905	43942-43946	PR_EXT:000006852	denotes	E2f1
T22906	43951-43958	CL:0000540	denotes	neurons
T22907	43959-43973	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T22908	44006-44012	SO_EXT:sequence_rescue_process	denotes	rescue
T22909	44016-44019	CL:0000604	denotes	rod
T22910	44025-44029	CL:0000573	denotes	cone
T22911	44071-44082	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signal flow
T22912	44088-44102	CL:0000210	denotes	photoreceptors
T22913	44106-44113	_FRAGMENT	denotes	bipolar
T22914	44127-44132	CL:0000103	denotes	cells
T22915	44118-44132	CL:0000561	denotes	amacrine cells
T22916	44127-44132	CL_GO_EXT:cell	denotes	cells
T22917	44147-44152	GO:0016265	denotes	death
T22918	44153-44158	SO_EXT:0000704	denotes	genes
T22919	44175-44177	PR_EXT:000013773	denotes	Rb
T22920	44181-44186	CL_GO_EXT:cell	denotes	cells
T22921	44192-44200	SO_EXT:sequence_deletion_process	denotes	deleting
T22922	44201-44205	PR_EXT:000006852	denotes	E2f1
T22923	44215-44219	PR_EXT:000006853	denotes	E2f2
T22924	44223-44227	PR_EXT:000006854	denotes	E2f3
T22925	44244-44253	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T22926	44262-44266	PR_EXT:000006852	denotes	E2f1
T22927	44276-44284	GO:0065007	denotes	regulate
T22928	44285-44300	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22929	44353-44360	UBERON:0000966	denotes	retinal
T22930	44353-44365	CL:0009004	denotes	retinal cell
T22931	44361-44365	CL_GO_EXT:cell	denotes	cell
T22932	44361-44376	GO:0048469	denotes	cell maturation
T22933	44447-44456	GO:0065007	denotes	regulated
T22934	44470-44475	GO:0016265	denotes	death
T22935	44515-44522	UBERON:0000966	denotes	retinal
T22936	44515-44528	CL:0009004	denotes	retinal cells
T22937	44523-44528	CL_GO_EXT:cell	denotes	cells
T22938	44540-44554	CL:0000210	denotes	photoreceptors
T22939	44561-44574	GO_EXT:transcription	denotes	transcription
T22940	44561-44582	GO_EXT:transcription_factor	denotes	transcription factors
T22941	44596-44611	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22942	44638-44640	PR_EXT:000013773	denotes	Rb
T22943	44666-44670	PR_EXT:000006852	denotes	E2f1
T22944	44671-44679	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T22945	44680-44687	SO_EXT:sequence_rescue_process	denotes	rescues
T22946	44688-44692	CL_GO_EXT:cell	denotes	cell
T22947	44722-44727	GO:0016265	denotes	death
T22948	44733-44748	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T22949	44769-44771	PR_EXT:000013773	denotes	Rb
T22950	44775-44781	SO_EXT:sequence_cloned_entity	denotes	clones
T22951	44804-44814	NCBITaxon:11632	denotes	retrovirus
T22952	44815-44821	SO_EXT:0000440	denotes	vector
T22953	44911-44915	PR_EXT:000006852	denotes	E2f1
T22954	44920-44930	GO:0010467	denotes	expression
T22955	44942-44956	CL:0000210	denotes	photoreceptors
T22956	44985-44994	GO:0006915	denotes	apoptosis
T22957	45049-45053	PR_EXT:000006852	denotes	E2f1
T22958	45117-45121	PR_EXT:E2F	denotes	E2fs
T22959	45141-45150	GO:0006915	denotes	apoptosis
T22960	45154-45156	PR_EXT:000013773	denotes	Rb
T22961	45160-45165	CL_GO_EXT:cell	denotes	cells
T22962	45183-45192	GO:0065007	denotes	regulated
T22963	45193-45197	PR_EXT:000006852	denotes	E2f1
T22964	45214-45220	UBERON:0000966	denotes	retina
T22965	45265-45267	PR_EXT:000013773	denotes	Rb
T22966	45280-45290	GO:0010467	denotes	expression
T22967	45313-45317	CL_GO_EXT:cell	denotes	cell
T22968	45313-45326	GO:0051301	denotes	cell division
T22969	45340-45349	GO:0006915	denotes	apoptosis
T22970	45371-45375	PR_EXT:000006852	denotes	E2f1
T22971	45395-45399	PR_EXT:E2F	denotes	E2fs
T22972	45479-45482	PR_EXT:000013773	denotes	RB1
T22973	45483-45484	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22974	45485-45486	SO_EXT:sequence_nullness_or_absence	denotes	−
T22975	45487-45493	NCBITaxon:9606	denotes	humans
T22976	45520-45526	SO_EXT:sequence_rescue_process	denotes	rescue
T22977	45534-45536	PR_EXT:000013773	denotes	Rb
T22978	45540-45543	CL:0000604	denotes	rod
T22979	45544-45551	CL:0000103	denotes	bipolar
T22980	45599-45603	CL:0000573	denotes	cone
T22981	45604-45611	CL:0000103	denotes	bipolar
T22982	45629-45633	PR_EXT:000006852	denotes	E2f1
T22983	45634-45642	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T22984	45671-45679	GO_EXT:reaction_or_response	denotes	response
T22985	45687-45689	PR_EXT:000013773	denotes	Rb
T22986	45690-45694	PR_EXT:000006852	denotes	E2f1
T22987	45699-45705	UBERON:0000966	denotes	retina
T22988	45722-45726	PR_EXT:000006852	denotes	E2f1
T22989	45738-45744	UBERON:0000966	denotes	retina
T22990	45787-45789	PR_EXT:000013773	denotes	Rb
T22991	45797-45817	GO:0046549	denotes	development of cones
T22992	45797-45811	_FRAGMENT	denotes	development of
T22993	45827-45832	GO:0048468	denotes	cells
T22994	45843-45848	GO:0048468	denotes	cells
T22995	45812-45817	CL:0000573	denotes	cones
T22996	45819-45832	CL:0000103	denotes	bipolar cells
T22997	45827-45832	CL_GO_EXT:cell	denotes	cells
T22998	45843-45848	CL_GO_EXT:cell	denotes	cells
T22999	45876-45884	GO:0036367	denotes	photopic
T23000	45956-45958	PR_EXT:000013773	denotes	Rb
T23001	45959-45963	PR_EXT:000006852	denotes	E2f1
T23002	45968-45974	UBERON:0000966	denotes	retina
T24511	46202-46206	PR_EXT:000006852	denotes	E2f1
T24512	46283-46291	CHEBI_PR_EXT:protein	denotes	proteins
T24513	46359-46371	CL:0000099	denotes	interneurons
T24514	46455-46457	PR_EXT:000013773	denotes	Rb
T24515	46458-46467	GO:0065007	denotes	regulates
T24516	46468-46480	GO:0022008	denotes	neurogenesis
T24517	46497-46504	GO:0007067	denotes	mitosis
T24518	46506-46508	PR_EXT:000013773	denotes	Rb
T24519	46509-46514	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T24520	46562-46570	CL:0000540	denotes	neuronal
T24521	46571-46576	CL_GO_EXT:cell	denotes	cells
T24522	46586-46601	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T24523	46603-46613	CL:0000136	denotes	adipocytes
T24524	46619-46623	UBERON_EXT:bone_element_or_tissue	denotes	bone
T24525	46628-46633	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T24526	46650-46656	UBERON:0000479	denotes	tissue
T24527	46666-46679	GO_EXT:transcription	denotes	transcription
T24528	46666-46687	GO_EXT:transcription_factor	denotes	transcription factors
T24529	46701-46716	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24530	46740-46742	PR_EXT:000013773	denotes	Rb
T24531	46752-46758	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T24532	46759-46774	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24533	46791-46796	PR_EXT:000010875	denotes	Myod1
T24534	46883-46886	PR_EXT:E2F	denotes	E2f
T24535	46939-46941	PR_EXT:000013773	denotes	Rb
T24536	46955-46970	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24537	46979-46983	PR_EXT:000006854	denotes	E2f3
T24538	47006-47008	PR_EXT:000013773	denotes	Rb
T24539	47015-47690	GO:0007067	denotes	tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati
T24540	47700-47715	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24541	47724-47728	PR_EXT:000006854	denotes	E2f3
T24542	47760-47771	GO:0065007	denotes	controlling
T24543	47784-47789	GO:0016265	denotes	death
T24544	47791-47795	PR_EXT:000006854	denotes	E2f3
T24545	47796-47804	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T24546	47805-47812	SO_EXT:sequence_rescue_process	denotes	rescued
T24547	47813-47815	PR_EXT:000013773	denotes	Rb
T24548	47861-47874	GO:0008283	denotes	proliferation
T24549	47878-47883	GO:0016265	denotes	death
T24550	47893-47897	PR_EXT:000006852	denotes	E2f1
T24551	47898-47906	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T24552	47925-47938	GO:0008283	denotes	proliferation
T24553	47943-47948	GO:0016265	denotes	death
T24554	47961-47967	SO_EXT:sequence_rescue_process	denotes	rescue
T24555	47972-47987	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24556	47996-48005	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelling
T24557	48021-48025	PR_EXT:000006852	denotes	E2f1
T24558	48034-48038	PR_EXT:000006854	denotes	E2f3
T24559	48039-48047	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T24560	48057-48059	PR_EXT:000013773	denotes	Rb
T24561	48087-48095	SO_EXT:sequence_deletion_process	denotes	deleting
T24562	48096-48100	PR_EXT:000006852	denotes	E2f1
T24563	48110-48114	PR_EXT:000006854	denotes	E2f3
T24564	48127-48136	GO:0065007	denotes	regulated
T24565	48137-48147	GO:0010467	denotes	expression
T24566	48151-48155	CL_GO_EXT:cell	denotes	cell
T24567	48151-48161	GO:0007049	denotes	cell cycle
T24568	48166-48175	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T24569	48176-48181	SO_EXT:0000704	denotes	genes
T24570	48189-48191	PR_EXT:000013773	denotes	Rb
T24571	48195-48201	UBERON:0000966	denotes	retina
T24572	48203-48207	PR_EXT:000006854	denotes	E2f3
T24573	48211-48220	GO:0010467	denotes	expressed
T24574	48236-48239	UBERON:0001017	denotes	CNS
T24575	48236-48247	CL:0000117	denotes	CNS neurons
T24576	48280-48284	CL_GO_EXT:cell	denotes	cell
T24577	48280-48290	GO:0007049	denotes	cell-cycle
T24578	48314-48316	PR_EXT:000013773	denotes	Rb
T24579	48320-48329	UBERON:0001890	denotes	forebrain
T24580	48320-48337	CL:0012001	denotes	forebrain neurons
T24581	48350-48354	PR_EXT:000006854	denotes	E2f3
T24582	48420-48422	PR_EXT:000013773	denotes	Rb
T24583	48448-48456	CL:0000540	denotes	neuronal
T24584	48457-48472	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24585	48520-48522	PR_EXT:000013773	denotes	Rb
T24586	48549-48553	PR_EXT:000006854	denotes	E2f3
T24587	48554-48561	SO_EXT:0001060	denotes	isoform
T24588	48584-48599	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24589	48640-48642	PR_EXT:000013773	denotes	Rb
T24590	48687-48696	GO:0044838	denotes	quiescent
T24591	48697-48702	CL_GO_EXT:cell	denotes	cells
T24592	48793-48796	PR_EXT:E2F	denotes	E2f
T24593	48797-48804	CHEBI_PR_EXT:protein	denotes	protein
T24594	48805-48812	SO_EXT:0001060	denotes	isoform
T24595	48862-48864	PR_EXT:000013773	denotes	Rb
T24596	48865-48874	GO:0065007	denotes	regulates
T24597	48879-48894	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24598	48903-48908	PR_EXT:000028775	denotes	E2f3a
T24599	48970-48978	SO_EXT:sequence_deletion_process	denotes	deleting
T24600	48996-49002	SO_EXT:sequence_rescue_process	denotes	rescue
T24601	49007-49022	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24602	49076-49080	SO_EXT:sequence_nullness	denotes	null
T24603	49081-49085	NCBITaxon:10088	denotes	mice
T24604	49121-49123	PR_EXT:000013773	denotes	Rb
T24605	49135-49144	GO:0065007	denotes	regulates
T24606	49149-49164	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T24607	49188-49192	PR_EXT:000006854	denotes	E2f3
T24608	49193-49200	SO_EXT:0001060	denotes	isoform
T25665	49552-49557	PR_EXT:000028775	denotes	E2f3a
T25666	49566-49573	GO:0005634	denotes	nuclear
T25644	49212-49217	PR_EXT:000028775	denotes	E2f3a
T25645	49228-49240	GO_PATO_EXT:biological_localization_process_or_quality	denotes	Localization
T25646	49245-49256	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T25647	49248-49256	CL_GO_EXT:cell	denotes	cellular
T25648	49269-49272	PR_EXT:E2F	denotes	E2f
T25649	49273-49281	SO_EXT:0001060	denotes	isoforms
T25650	49330-49335	PR_EXT:000028775	denotes	E2f3a
T25651	49356-49366	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T25652	49367-49378	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T25653	49384-49390	SO_EXT:sequence_coding_function	denotes	encode
T25654	49395-49398	SO_EXT:0001528	denotes	NLS
T25655	49400-49403	CHEBI_SO_EXT:DNA	denotes	DNA
T25656	49404-49411	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T25657	49446-49448	PR_EXT:000013773	denotes	Rb
T25658	49449-49456	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T25659	49457-49464	SO_EXT:0000417	denotes	domains
T25660	49498-49509	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T25661	49501-49509	CL_GO_EXT:cell	denotes	cellular
T25662	49537-49544	UBERON:0000966	denotes	retinal
T25663	49537-49550	CL:0009004	denotes	retinal cells
T25664	49545-49550	CL_GO_EXT:cell	denotes	cells
T25667	49578-49589	GO:0005737	denotes	cytoplasmic
T25668	49611-49618	GO:0005634	denotes	nuclear
T25669	49644-49651	CHEBI_EXT:residue	denotes	residue
T25670	49652-49661	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-termini
T25671	49665-49670	PR_EXT:000028775	denotes	E2f3a
T25672	49743-49747	PR_EXT:000006852	denotes	E2f1
T25673	49749-49753	PR_EXT:000006853	denotes	E2f2
T25674	49759-49764	PR_EXT:000028775	denotes	E2f3a
T25675	49765-49770	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T25676	49771-49776	PR_EXT:000005115	denotes	Ccna2
T25677	49793-49812	GO_EXT:negative_regulation	denotes	negative regulatory
T25678	49835-49839	PR_EXT:E2F	denotes	E2fs
T25679	49852-49859	GO:0051320	denotes	S-phase
T25680	49907-49913	SO_EXT:0000417	denotes	domain
T25681	49915-49920	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T25682	49928-49937	GO:0065007	denotes	regulated
T25683	49941-49946	PR_EXT:000005115	denotes	Ccna2
T25684	49960-49966	SO_EXT:0000417	denotes	domain
T25685	50032-50034	PR_EXT:000013773	denotes	Rb
T25686	50046-50050	PR_EXT:TFDP	denotes	Tfdp
T25687	50051-50059	CHEBI_PR_EXT:protein	denotes	proteins
T25688	50079-50082	PR_EXT:E2F	denotes	E2f
T25689	50083-50095	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T25690	50141-50143	PR_EXT:000013773	denotes	Rb
T25691	50148-50153	PR_EXT:000016269	denotes	Tfdp1
T25692	50154-50162	CHEBI_PR_EXT:protein	denotes	proteins
T25693	50167-50178	GO:0005737	denotes	cytoplasmic
T25694	50182-50189	UBERON:0000966	denotes	retinal
T25695	50182-50195	CL:0009004	denotes	retinal cells
T25696	50190-50195	CL_GO_EXT:cell	denotes	cells
T25697	50234-50236	PR_EXT:000013773	denotes	Rb
T25698	50241-50245	PR_EXT:000006854	denotes	E2f3
T25699	50248-50256	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localize
T25700	50264-50273	GO:0042995	denotes	processes
T25701	50279-50286	GO:0005634	denotes	nuclear
T25702	50287-50299	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T25703	50349-50353	PR_EXT:E2F	denotes	E2fs
T25704	50357-50372	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T25705	50373-50379	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T25706	50387-50391	PR_EXT:000006856	denotes	E2f5
T25707	50410-50417	GO:0005634	denotes	nucleus
T25708	50421-50430	GO:0005737	denotes	cytoplasm
T25709	50438-50442	PR_EXT:000006855	denotes	E2f4
T25710	50515-50520	PR_EXT:000028775	denotes	E2f3a
T25711	50538-50544	UBERON:0000966	denotes	retina
T25712	50603-50605	PR_EXT:000013773	denotes	Rb
T25713	50635-50640	PR_EXT:000028775	denotes	E2f3a
T25714	50694-50709	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T25715	50718-50723	PR_EXT:000028775	denotes	E2f3a
T26557	50747-50762	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T26558	50763-50765	PR_EXT:000013773	denotes	Rb
T26559	50818-50833	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T26560	50834-50839	CL_GO_EXT:cell	denotes	cells
T26561	50850-50854	CL_GO_EXT:cell	denotes	cell
T26562	50850-50860	GO:0007049	denotes	cell cycle
T26563	50868-50875	CL:0000540	denotes	neurons
T26564	50877-50880	_FRAGMENT	denotes	gut
T26565	50890-50899	UBERON:0003929	denotes	epithelia
T26566	50885-50899	UBERON:0019204	denotes	skin epithelia
T26567	50901-50907	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T26568	50913-50924	CL_UBERON_EXT:lens_fiber	denotes	lens fibres
T26569	50913-50924	CL:0011004	denotes	lens fibres
T26570	50956-50966	GO:0010467	denotes	expression
T26571	50994-50996	PR_EXT:000013773	denotes	Rb
T26572	51031-51036	CL_GO_EXT:cell	denotes	cells
T26573	51125-51140	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T26574	51141-51146	CL_GO_EXT:cell	denotes	cells
T26575	51202-51217	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T26576	51258-51264	UBERON:0000966	denotes	retina
T26577	51266-51281	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T26578	51293-51298	CL_GO_EXT:cell	denotes	cells
T26579	51326-51328	PR_EXT:000013773	denotes	Rb
T26580	51330-51337	GO_EXT:biological_movement_or_translocation_process	denotes	migrate
T26581	51364-51371	GO:0010467	denotes	express
T26582	51384-51391	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T26583	51416-51421	UBERON:0000955	denotes	brain
T26584	51423-51425	PR_EXT:000013773	denotes	Rb
T26585	51429-51436	CL:0000540	denotes	neurons
T26586	51437-51444	GO_EXT:biological_movement_or_translocation_process	denotes	migrate
T26587	51459-51475	UBERON:0003053	denotes	ventricular zone
T26588	51490-51495	PR_EXT:000016819	denotes	Tubb3
T26589	51497-51509	PR_EXT:000016819	denotes	βIII-tubulin
T26590	51540-51544	CHEBI:472552	denotes	BrdU
T26591	51558-51571	UBERON:0003929	denotes	gut epithelia
T26592	51573-51587	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T26593	51588-51599	CL:0000584	denotes	enterocytes
T26594	51600-51607	GO_EXT:biological_movement_or_translocation_process	denotes	migrate
T26595	51615-51620	GO_UBERON_EXT:villus	denotes	villi
T26596	51634-51644	GO:0010467	denotes	expression
T26597	51648-51657	CHEBI:28790	denotes	serotonin
T26598	51687-51691	CHEBI:472552	denotes	BrdU
T26599	51723-51738	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T26600	51774-51781	PR_EXT:000014968	denotes	Slc18a3
T26601	51786-51790	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T26602	51882-51887	CL_GO_EXT:cell	denotes	cells
T26603	51972-51987	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T26604	52000-52004	CL_GO_EXT:cell	denotes	cell
T26605	52058-52069	_FRAGMENT	denotes	division of
T26606	52097-52102	GO:0051301	denotes	cells
T26607	52081-52096	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T26608	52097-52102	CL_GO_EXT:cell	denotes	cells
T27186	52220-52225	PR_EXT:000028775	denotes	E2f3a
T27187	52238-52253	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T27188	52255-52260	PR_EXT:000028775	denotes	E2f3a
T27189	52279-52294	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27190	52328-52343	GO_EXT:transcription	denotes	transcriptional
T27191	52405-52416	GO:0005737	denotes	cytoplasmic
T27192	52418-52423	PR_EXT:000028775	denotes	E2f3a
T27193	52456-52460	SO_EXT:0000704	denotes	gene
T27194	52461-52471	GO:0065007	denotes	regulation
T27195	52507-52511	PR_EXT:E2F	denotes	E2fs
T27196	52512-52520	GO:0065007	denotes	regulate
T27197	52521-52536	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27198	52537-52542	SO_EXT:0000704	denotes	genes
T27199	52556-52560	CL_GO_EXT:cell	denotes	cell
T27200	52556-52566	GO:0007049	denotes	cell cycle
T27201	52567-52577	GO_EXT:regulator	denotes	regulators
T27202	52587-52593	PR_EXT:000003090	denotes	Cdkn1b
T27203	52600-52611	GO:0005737	denotes	cytoplasmic
T27204	52638-52653	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27205	52668-52681	GO_EXT:transcription	denotes	transcription
T27206	52668-52689	GO_EXT:transcription_factor	denotes	transcription factors
T27207	52690-52697	GO_EXT:biological_movement_or_translocation_process	denotes	shuttle
T27208	52706-52713	GO:0005634	denotes	nucleus
T27209	52718-52727	GO:0005737	denotes	cytoplasm
T27210	52735-52747	GO:0022008	denotes	neurogenesis
T27211	52817-52822	PR_EXT:000028775	denotes	E2f3a
T27212	52839-52844	SO_EXT:0000704	denotes	genes
T27213	52848-52859	GO:0005737	denotes	cytoplasmic
T27214	52860-52868	CHEBI_PR_EXT:protein	denotes	proteins
T27215	52889-52896	CL:0000540	denotes	neurons
T27216	52939-52945	UBERON:0000966	denotes	retina
T27217	52964-52980	CL:0000561	denotes	amacrine neurons
T27757	52991-52995	PR_EXT:E2F	denotes	E2fs
T27758	53008-53010	PR_EXT:000013773	denotes	Rb
T27759	53049-53051	PR_EXT:000013773	denotes	Rb
T27760	53061-53076	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27761	53084-53092	CL:0000540	denotes	neuronal
T27762	53093-53098	CL_GO_EXT:cell	denotes	cells
T27763	53107-53110	PR_EXT:E2F	denotes	E2f
T27764	53190-53194	CL_GO_EXT:cell	denotes	cell
T27765	53201-53214	GO_RO_EXT:developmental_differentiation_process	denotes	differentiate
T27766	53227-53229	PR_EXT:000013773	denotes	Rb
T27767	53233-53240	SO_EXT:sequence_deletion_process	denotes	deleted
T27768	53264-53267	PR_EXT:E2F	denotes	E2f
T27769	53308-53310	PR_EXT:000013773	denotes	Rb
T27770	53311-53318	SO_EXT:sequence_altered_entity	denotes	mutants
T27771	53331-53335	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T27772	53336-53339	PR_EXT:E2F	denotes	E2f
T27773	53353-53368	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27774	53388-53395	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T27775	53421-53429	CHEBI:75958	denotes	solution
T27776	53471-53478	SO_EXT:sequence_altered_entity	denotes	mutants
T27777	53482-53486	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T27778	53487-53490	PR_EXT:E2F	denotes	E2f
T27779	53510-53519	GO:0000785	denotes	chromatin
T27780	53577-53579	PR_EXT:000013773	denotes	Rb
T27781	53605-53611	UBERON:0000479	denotes	tissue
T27782	53621-53634	GO_EXT:transcription	denotes	transcription
T27783	53621-53642	GO_EXT:transcription_factor	denotes	transcription factors
T27784	53724-53726	PR_EXT:000013773	denotes	Rb
T27785	53750-53753	PR_EXT:E2F	denotes	E2f
T27786	53829-53831	PR_EXT:000013773	denotes	Rb
T27787	53835-53840	CL_GO_EXT:cell	denotes	cells
T27788	53845-53858	GO_RO_EXT:developmental_differentiation_process	denotes	differentiate
T27789	53887-53891	PR_EXT:E2F	denotes	E2fs
T27790	53952-53967	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T27791	53985-53987	PR_EXT:000013773	denotes	Rb
T27792	53991-53998	UBERON:0000479	denotes	tissues
T27793	54052-54055	PR_EXT:E2F	denotes	E2f
T28343	54253-54257	SO_EXT:0000346	denotes	loxP
T28344	54258-54262	NCBITaxon:10088	denotes	mice
T28345	54275-54279	PR_EXT:000006852	denotes	E2f1
T28346	54279-54280	SO_EXT:sequence_nullness_or_absence	denotes	–
T28347	54281-54282	SO_EXT:sequence_nullness_or_absence	denotes	–
T28348	54283-54287	NCBITaxon:10088	denotes	mice
T28349	54289-54293	PR_EXT:000006853	denotes	E2f2
T28350	54293-54294	SO_EXT:sequence_nullness_or_absence	denotes	–
T28351	54295-54296	SO_EXT:sequence_nullness_or_absence	denotes	–
T28352	54297-54301	NCBITaxon:10088	denotes	mice
T28353	54303-54307	PR_EXT:000006854	denotes	E2f3
T28354	54307-54311	SO_EXT:0000346	denotes	loxP
T28355	54312-54316	SO_EXT:0000346	denotes	loxP
T28356	54317-54321	NCBITaxon:10088	denotes	mice
T28357	54327-54332	PR_EXT:000028775	denotes	E2f3a
T28358	54332-54333	SO_EXT:sequence_nullness_or_absence	denotes	−
T28359	54334-54335	SO_EXT:sequence_nullness_or_absence	denotes	−
T28360	54336-54340	NCBITaxon:10088	denotes	mice
T28361	54438-54443	PR_EXT:000028775	denotes	E2f3a
T28362	54443-54444	SO_EXT:sequence_nullness_or_absence	denotes	−
T28363	54445-54446	SO_EXT:sequence_nullness_or_absence	denotes	−
T28364	54447-54451	NCBITaxon:10088	denotes	mice
T28365	54481-54485	NCBITaxon:10088	denotes	Mice
T28366	54499-54508	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T28367	54701-54708	SO_EXT:0000112	denotes	primers
T28368	54729-54734	PR_EXT:000028775	denotes	E2f3a
T28369	54734-54735	SO_EXT:sequence_nullness_or_absence	denotes	−
T28370	54736-54737	SO_EXT:sequence_nullness_or_absence	denotes	−
T28371	54738-54742	NCBITaxon:10088	denotes	mice
T28372	54748-54753	PR_EXT:000028775	denotes	E2f3a
T28373	54787-54792	PR_EXT:000028775	denotes	E2f3a
T28374	54831-54836	PR_EXT:000028775	denotes	E2f3a
T29576	55544-55555	CHEBI:30769	denotes	citric acid
T29577	55556-55564	CHEBI:75958	denotes	solution
T29578	55729-55736	CHEBI:60004	denotes	mixture
T29579	55737-55745	CHEBI:75958	denotes	solution
T29558	54920-54928	UBERON:0010230	denotes	Eyeballs
T29559	54946-54962	CHEBI_EXT:paraformaldehye	denotes	paraformaldehyde
T29560	55151-55158	GO:0051320	denotes	S-phase
T29561	55169-55173	CHEBI:472552	denotes	BrdU
T29562	55187-55191	UBERON_EXT:body	denotes	body
T29563	55218-55230	UBERON:0001179	denotes	peritoneally
T29564	55244-55253	GO_EXT:killing	denotes	sacrifice
T29565	55255-55259	CHEBI:472552	denotes	BrdU
T29566	55261-55266	CL_GO_EXT:cell	denotes	cells
T29567	55289-55295	CHEBI:15956	denotes	biotin
T29568	55289-55306	MOP:0000093	denotes	biotin-conjugated
T29569	55307-55312	NCBITaxon:9940	denotes	sheep
T29570	55324-55332	GO:0042571	denotes	antibody
T29571	55417-55427	GO:0042571	denotes	antibodies
T29572	55459-55463	PR_EXT:000006854	denotes	E2f3
T29573	55465-55470	PR_EXT:000010425	denotes	Mki67
T29574	55476-55478	PR_EXT:000013773	denotes	Rb
T29575	55489-55496	CHEBI_EXT:59132	denotes	antigen
T29580	55770-55806	GO_PR_EXT:DNA_nucleotidylexotransferase	denotes	terminal deoxynucleotide transferase
T29581	55779-55794	CHEBI_SO_EXT:deoxyribonucleotide	denotes	deoxynucleotide
T29582	55816-55822	CHEBI:15956	denotes	biotin
T29583	55826-55830	CHEBI_EXT:dUTP	denotes	dUTP
T29584	55842-55847	CHEBI:35696	denotes	CoCl2
T29585	55861-55897	GO_PR_EXT:DNA_nucleotidylexotransferase	denotes	terminal deoxynucleotide transferase
T29586	55870-55885	CHEBI_SO_EXT:deoxyribonucleotide	denotes	deoxynucleotide
T29587	55898-55904	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T29588	55929-55934	CHEBI:15377	denotes	water
T29589	55961-55964	CHEBI_EXT:saline_sodium_citrate	denotes	SSC
T29590	55965-55971	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T29591	56002-56011	CHEBI:52661	denotes	Alexa 488
T29592	56016-56025	CHEBI:51766	denotes	Alexa 568
T29593	56049-56058	CHEBI_EXT:polyatomic_entity_or_group	denotes	Molecular
T29594	56059-56065	CHEBI_SO_EXT:molecular_probe	denotes	Probes
T29595	56134-56144	GO:0042571	denotes	antibodies
T29596	56148-56156	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T29597	56157-56162	CL_GO_EXT:cell	denotes	cells
T29598	56185-56191	NCBITaxon:9793	denotes	donkey
T29599	56197-56202	NCBITaxon:10088	denotes	mouse
T29600	56203-56212	CHEBI:52661	denotes	Alexa 488
T29601	56216-56225	CHEBI:51766	denotes	Alexa 568
T29602	56227-56233	NCBITaxon:9793	denotes	donkey
T29603	56239-56245	NCBITaxon:9986	denotes	rabbit
T29604	56246-56255	CHEBI:52661	denotes	Alexa 488
T29605	56259-56268	CHEBI:51766	denotes	Alexa 568
T29606	56270-56276	NCBITaxon:9793	denotes	donkey
T29607	56282-56286	NCBITaxon:9925	denotes	goat
T29608	56287-56296	CHEBI:52661	denotes	Alexa 488
T29609	56300-56309	CHEBI:51766	denotes	Alexa 568
T29610	56328-56337	CHEBI:52661	denotes	Alexa 488
T29611	56341-56350	CHEBI:51766	denotes	Alexa 568
T29612	56361-56370	CHEBI_EXT:polyatomic_entity_or_group	denotes	Molecular
T29613	56371-56377	CHEBI_SO_EXT:molecular_probe	denotes	Probes
T29614	56380-56386	GO:0005634	denotes	Nuclei
T29615	56413-56440	CHEBI:51231	denotes	4,6-diamidino-2-phenyindole
T29616	56442-56446	CHEBI:51231	denotes	DAPI
T29617	56485-56493	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	Labelled
T29618	56494-56499	CL_GO_EXT:cell	denotes	cells
T29619	56666-56674	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T29620	56766-56772	UBERON:0000966	denotes	retina
T29621	56819-56830	UBERON:0004086	denotes	ventricular
T29622	56843-56849	UBERON:0000966	denotes	retina
T29623	56895-56902	UBERON:0001797	denotes	vitreal
T29624	56933-56938	CL_GO_EXT:cell	denotes	cells
T29625	56944-56953	GO:0010467	denotes	expressed
T29626	56994-57000	UBERON:0000966	denotes	retina
T29627	57014-57019	CL_GO_EXT:cell	denotes	cells
T29628	57058-57065	GO:0010467	denotes	express
T29629	57075-57079	CL_GO_EXT:cell	denotes	cell
T29630	57290-57297	GO:0051320	denotes	S-phase
T29631	57299-57306	GO:0000279	denotes	M-phase
T29632	57312-57321	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T29633	57312-57327	CL:0000445	denotes	apoptotic cells
T29634	57322-57327	CL_GO_EXT:cell	denotes	cells
T29635	57383-57394	UBERON_EXT:optic_nerve	denotes	optic nerve
T29636	57414-57428	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T29637	57429-57433	CL_GO_EXT:cell	denotes	cell
T29638	57508-57519	UBERON_EXT:optic_nerve	denotes	optic nerve
T29639	57553-57556	UBERON:0000970	denotes	eye
T29640	57567-57571	UBERON:0000970	denotes	eyes
T30725	57610-57613	CHEBI_SO_EXT:RNA	denotes	RNA
T30726	57626-57647	GO:0001171	denotes	reverse transcription
T30727	57664-57667	CHEBI_SO_EXT:RNA	denotes	RNA
T30728	57696-57713	UBERON:0013682	denotes	peripheral retina
T30729	57727-57734	CHEBI_EXT:33893	denotes	reagent
T30730	57802-57807	GO_EXT:0004540	denotes	RNase
T30731	57813-57818	GO_EXT:0004536	denotes	DNase
T30732	57820-57823	CHEBI_SO_EXT:DNA	denotes	DNA
T30733	57871-57874	CHEBI_SO_EXT:DNA	denotes	DNA
T30734	57903-57907	SO_EXT:cDNA	denotes	cDNA
T30735	57949-57952	CHEBI_SO_EXT:RNA	denotes	RNA
T30736	58026-58033	SO_EXT:0000112	denotes	primers
T30737	58218-58228	CHEBI_GO_EXT:biological_process_or_quality_or_role	denotes	biological
T30738	58242-58252	CHEBI:51461	denotes	SYBR Green
T30739	58264-58267	CHEBI:60004	denotes	Mix
T30740	58415-58425	CHEBI:51461	denotes	SYBR Green
T30741	58437-58440	CHEBI:60004	denotes	Mix
T30742	58457-58464	_FRAGMENT	denotes	forward
T30743	58477-58483	SO_EXT:0000121	denotes	primer
T30744	58469-58483	SO_EXT:0000132	denotes	reverse primer
T30745	58514-58517	CHEBI:15377	denotes	H2O
T30746	58530-58541	CHEBI_EXT:77182	denotes	Food Colour
T30747	58597-58601	SO_EXT:cDNA	denotes	cDNA
T30748	58631-58634	CHEBI:15377	denotes	H2O
T30749	58649-58660	CHEBI_EXT:77182	denotes	Food Colour
T30750	58693-58705	GO_EXT:macromolecule_denaturation	denotes	denaturation
T30751	58728-58737	GO:0097617	denotes	annealing
T30752	58998-59004	SO_EXT:0000112	denotes	primer
T30753	59047-59058	SO_EXT:genomic_DNA	denotes	genomic DNA
T30754	59055-59058	CHEBI_SO_EXT:DNA	denotes	DNA
T30755	59062-59066	SO_EXT:cDNA	denotes	cDNA
T30756	59124-59128	CHEBI_SO_EXT:RNA	denotes	RNAs
T30757	59148-59153	PR_EXT:000008735	denotes	Hprt1
T30758	59154-59158	CHEBI_SO_EXT:mRNA	denotes	mRNA
T31552	59183-59188	NCBITaxon:10088	denotes	Mouse
T31553	59189-59196	UBERON:0000966	denotes	retinas
T31554	59217-59224	GO_EXT:biological_movement_or_translocation_process	denotes	passing
T31555	59301-59309	CHEBI:75958	denotes	solution
T31556	59311-59318	GO:0005634	denotes	Nuclear
T31557	59323-59334	GO:0005737	denotes	cytoplasmic
T31558	59335-59343	CHEBI_PR_EXT:protein	denotes	proteins
T31559	59376-59383	GO:0005634	denotes	Nuclear
T31560	59388-59399	GO:0005737	denotes	Cytoplasmic
T31561	59481-59489	CHEBI_PR_EXT:protein	denotes	Proteins
T31562	59512-59515	CHEBI:8984	denotes	SDS
T31563	59525-59536	GO_EXT:biological_movement_or_translocation_process	denotes	transferred
T31564	59540-59554	CHEBI:53325	denotes	nitrocellulose
T31565	59600-59604	UBERON:0001913	denotes	milk
T31566	59646-59654	GO:0042571	denotes	antibody
T31567	59726-59733	CHEBI:34683	denotes	Na2HPO4
T31568	59742-59749	CHEBI:37585	denotes	NaH2PO4
T31569	59757-59761	CHEBI:26710	denotes	NaCl
T31570	59768-59776	CHEBI:53424	denotes	Tween-20
T31571	59852-59863	NCBITaxon:3704	denotes	horseradish
T31572	59864-59874	GO_EXT:0004601	denotes	peroxidase
T31573	59875-59885	MOP:0000779	denotes	conjugated
T31574	59886-59894	GO:0042571	denotes	antibody
T31575	60161-60171	GO:0042571	denotes	antibodies
T31576	60183-60188	PR_EXT:000006852	denotes	E2f-1
T31577	60199-60204	PR_EXT:000006854	denotes	E2f-3
T31578	60215-60221	PR_EXT:000005274	denotes	Cdkn1a
T31579	60223-60226	PR_EXT:000005274	denotes	p21
T31580	60237-60243	PR_EXT:000003090	denotes	Cdkn1b
T31581	60245-60248	PR_EXT:000003090	denotes	p27
T31582	60259-60265	PR_EXT:000013042	denotes	Pou4f2
T31583	60267-60272	PR_EXT:000013042	denotes	Brn3b
T31584	60288-60293	PR_EXT:000016269	denotes	Tfdp1
T31585	60295-60298	PR_EXT:000016269	denotes	Dp1
T31586	60437-60444	PR_EXT:000014968	denotes	Slc18a3
T31587	60446-60451	PR_EXT:000014968	denotes	VAChT
T32251	60545-60557	GO:1990603	denotes	dark-adapted
T32252	60558-60562	NCBITaxon:10088	denotes	mice
T32253	60591-60595	NCBITaxon:10088	denotes	mice
T32254	60601-60613	GO:1990603	denotes	dark-adapted
T32255	60628-60641	CHEBI_EXT:anaesthetic_process	denotes	anaesthetized
T32256	60648-60657	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	cutaneous
T32257	60671-60679	CHEBI:6121	denotes	ketamine
T32258	60730-60734	UBERON_EXT:body	denotes	body
T32259	60748-60754	UBERON:0001771	denotes	pupils
T32260	60820-60832	GO:1990603	denotes	dark-adapted
T32261	60834-60842	GO:1990603	denotes	scotopic
T32262	60848-60861	GO:0036367	denotes	light-adapted
T32263	60863-60871	GO:0036367	denotes	photopic
T32264	60885-60901	GO:0036367	denotes	Light adaptation
T32265	61136-61145	GO_EXT:reaction_or_response	denotes	responses
T32552	61390-61399	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T33335	4237-4241	PR_EXT:000006852	denotes	E2f1
T33336	4251-4255	PR_EXT:000006853	denotes	E2f2
T33337	4259-4263	PR_EXT:000006854	denotes	E2f3
T33338	4270-4277	SO_EXT:sequence_rescue_process	denotes	Rescues
T33339	4299-4303	CL_GO_EXT:cell	denotes	Cell
T33340	4299-4309	GO:0008219	denotes	Cell Death
T33341	4317-4319	PR_EXT:000013773	denotes	Rb
T33342	4323-4329	UBERON:0000966	denotes	Retina
T33343	4334-4341	UBERON:0000966	denotes	Retinal
T33344	4334-4353	GO:0060041	denotes	Retinal development
T33345	4366-4372	UBERON:0000966	denotes	retina
T33346	4394-4398	CL:0002672	denotes	RPCs
T33347	4420-4426	GO:0005634	denotes	nuclei
T33348	4429-4432	CL:0002672	denotes	RPC
T33349	4433-4437	CL_GO_EXT:cell	denotes	cell
T33350	4433-4444	GO:0044297	denotes	cell bodies
T33351	4461-4470	GO:0042995	denotes	processes
T33352	4500-4504	CL_GO_EXT:cell	denotes	cell
T33353	4500-4510	GO:0007049	denotes	cell cycle
T33354	4540-4544	CL:0002672	denotes	RPCs
T33355	4554-4561	GO:0007067	denotes	mitotic
T33356	4590-4596	GO:0005634	denotes	nuclei
T33357	4624-4627	UBERON:0001792	denotes	GCL
T33358	4659-4663	CL:0002672	denotes	RPCs
T33359	4694-4708	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T33360	4709-4713	CL:0000604	denotes	rods
T33361	4715-4716	CL:0000604	denotes	r
T33362	4722-4727	CL:0000573	denotes	cones
T33363	4729-4730	CL:0000573	denotes	c
T33364	4739-4742	UBERON:0001789	denotes	ONL
T33365	4744-4754	_FRAGMENT	denotes	horizontal
T33366	4802-4807	CL:0000745	denotes	cells
T33367	4756-4757	CL:0000745	denotes	h
T33368	4760-4767	_FRAGMENT	denotes	bipolar
T33369	4802-4807	CL:0000103	denotes	cells
T33370	4769-4770	CL:0000103	denotes	b
T33371	4773-4779	_FRAGMENT	denotes	Müller
T33372	4802-4807	CL:0011107	denotes	cells
T33373	4781-4782	CL:0011107	denotes	m
T33374	4789-4797	_FRAGMENT	denotes	amacrine
T33375	4802-4807	CL:0000561	denotes	cells
T33376	4799-4800	CL:0000561	denotes	a
T33377	4802-4807	CL_GO_EXT:cell	denotes	cells
T33378	4815-4818	UBERON:0001791	denotes	INL
T33379	4824-4832	UBERON:0000045	denotes	ganglion
T33380	4824-4832	_FRAGMENT	denotes	ganglion
T33381	4860-4865	CL:0000740	denotes	cells
T33382	4834-4835	UBERON:0000045	denotes	g
T33383	4834-4835	_FRAGMENT	denotes	g
T33384	4851-4865	CL:0000561	denotes	amacrine cells
T33385	4860-4865	CL_GO_EXT:cell	denotes	cells
T33386	4873-4876	UBERON:0001792	denotes	GCL
T33387	4915-4917	PR_EXT:000013773	denotes	Rb
T33388	4932-4940	GO:0065007	denotes	regulate
T33389	4941-4945	CL_GO_EXT:cell	denotes	cell
T33390	4941-4951	GO:0007049	denotes	cell cycle
T33391	4956-4965	GO:0006915	denotes	apoptosis
T33392	4980-4984	PR_EXT:E2F	denotes	E2fs
T33393	5001-5016	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T33394	5033-5039	UBERON:0000479	denotes	tissue
T33395	5049-5062	GO_EXT:transcription	denotes	transcription
T33396	5049-5070	GO_EXT:transcription_factor	denotes	transcription factors
T33397	5081-5083	PR_EXT:000013773	denotes	Rb
T33398	5108-5123	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T33399	5177-5182	GO:0016265	denotes	death
T33400	5206-5216	GO:0065007	denotes	regulation
T33401	5220-5235	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T33402	5236-5241	SO_EXT:0000704	denotes	genes
T33403	5245-5249	PR_EXT:E2F	denotes	E2fs
T33404	5272-5279	UBERON:0000966	denotes	retinal
T33405	5306-5315	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T33406	5342-5348	GO:0005634	denotes	nuclei
T33407	5350-5354	CHEBI:51231	denotes	DAPI
T33408	5371-5378	GO:0051320	denotes	S-phase
T33409	5385-5389	CHEBI:472552	denotes	BrdU
T33410	5403-5412	GO:0006915	denotes	apoptosis
T33411	5481-5485	CHEBI:472552	denotes	BrdU
T33412	5487-5492	CL_GO_EXT:cell	denotes	cells
T33413	5506-5510	CHEBI:472552	denotes	BrdU
T33414	5512-5517	CL_GO_EXT:cell	denotes	cells
T33415	5521-5524	UBERON:0001792	denotes	GCL
T33416	5553-5558	CL_GO_EXT:cell	denotes	cells
T33417	5574-5576	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T33418	5593-5597	PR_EXT:E2F	denotes	E2fs
T33419	5602-5605	PR_EXT:E2F	denotes	E2f
T33420	5613-5618	SO_EXT:0000704	denotes	genes
T33421	5625-5632	UBERON:0000966	denotes	retinas
T33422	5650-5659	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T33423	5712-5719	NCBITaxon:33208	denotes	animals
T33424	5781-5783	SO_EXT:wild_type_entity_or_quality	denotes	WT
T33425	5798-5807	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T34375	14696-14702	UBERON:0000966	denotes	Retina
T34376	14718-14725	UBERON:0000966	denotes	retinal
T34377	14740-14744	NCBITaxon:10088	denotes	mice
T34364	14628-14632	PR_EXT:000006852	denotes	E2f1
T34365	14633-14641	SO_EXT:sequence_deletion_entity_or_process	denotes	Deletion
T34366	14642-14649	SO_EXT:sequence_rescue_process	denotes	Rescues
T34367	14650-14658	UBERON:0000045	denotes	Ganglion
T34368	14650-14658	_FRAGMENT	denotes	Ganglion
T34369	14677-14682	CL:0000740	denotes	Cells
T34370	14660-14663	_FRAGMENT	denotes	Rod
T34371	14677-14682	CL:0000604	denotes	Cells
T34372	14669-14682	CL:0000748	denotes	Bipolar Cells
T34373	14677-14682	CL_GO_EXT:cell	denotes	Cells
T34374	14690-14692	PR_EXT:000013773	denotes	Rb
T34378	14771-14780	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T34379	14798-14804	GO:0005634	denotes	nuclei
T34380	14806-14810	CHEBI:51231	denotes	DAPI
T34381	14822-14829	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T34382	14842-14850	UBERON:0000045	denotes	ganglion
T34383	14842-14856	CL:0000740	denotes	ganglion cells
T34384	14851-14856	CL_GO_EXT:cell	denotes	cells
T34385	14858-14864	PR_EXT:000013042	denotes	Pou4f2
T34386	14872-14876	CL:0000604	denotes	rods
T34387	14881-14886	CL:0000573	denotes	cones
T34388	14888-14891	PR_EXT:000014434	denotes	Sag
T34389	14893-14896	CL:0000604	denotes	rod
T34390	14893-14905	PR_EXT:000014434	denotes	rod arrestin
T34391	14920-14937	CL:0000751	denotes	rod bipolar cells
T34392	14932-14937	CL_GO_EXT:cell	denotes	cells
T34393	14939-14944	PR_EXT:000003058	denotes	Prkca
T34394	14957-14962	PR_EXT:000004937	denotes	Cabp5
T34395	15014-15020	PR_EXT:000013042	denotes	Pou4f2
T34396	15022-15030	UBERON:0000045	denotes	ganglion
T34397	15022-15036	CL:0000740	denotes	ganglion cells
T34398	15031-15036	CL_GO_EXT:cell	denotes	cells
T34399	15060-15065	PR_EXT:000003058	denotes	Prkca
T34400	15071-15076	PR_EXT:000004937	denotes	Cabp5
T34401	15078-15091	CL:0000103	denotes	bipolar cells
T34402	15086-15091	CL_GO_EXT:cell	denotes	cells
T34403	15114-15117	UBERON:0001789	denotes	ONL
T34404	15150-15154	CL:0000604	denotes	rods
T34405	15207-15214	NCBITaxon:33208	denotes	animals
T34406	15272-15279	UBERON:0000966	denotes	retinas
T34407	15283-15285	SO_EXT:wild_type_entity_or_quality	denotes	WT
T34408	15304-15313	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T34409	15465-15474	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T34410	15481-15493	GO:1990603	denotes	dark-adapted
T34411	15495-15503	GO:1990603	denotes	scotopic
T34412	15698-15707	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T34413	15715-15729	CL:0000210	denotes	photoreceptors
T34414	15853-15861	GO_EXT:reaction_or_response	denotes	response
T34415	15880-15888	CL:0000103	denotes	bipolars
T35088	23694-23709	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T35089	23721-23723	PR_EXT:000013773	denotes	Rb
T35090	23763-23765	SO_EXT:wild_type_entity_or_quality	denotes	WT
T35091	23767-23769	PR_EXT:000013773	denotes	Rb
T35092	23778-23780	PR_EXT:000013773	denotes	Rb
T35093	23781-23785	PR_EXT:000006852	denotes	E2f1
T35094	23790-23796	UBERON:0000966	denotes	retina
T35095	23814-23820	GO:0005634	denotes	nuclei
T35096	23822-23826	CHEBI:51231	denotes	DAPI
T35097	23835-23840	PR_EXT:000004968	denotes	Calb2
T35098	23854-23861	PR_EXT:000014968	denotes	Slc18a3
T35099	23919-23921	SO_EXT:wild_type_entity_or_quality	denotes	WT
T35100	23926-23928	PR_EXT:000013773	denotes	Rb
T35101	23932-23938	UBERON:0000966	denotes	retina
T35102	23956-23962	GO:0005634	denotes	nuclei
T35103	23964-23968	CHEBI:51231	denotes	DAPI
T35104	23977-23981	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T35105	23986-23993	PR_EXT:000014968	denotes	Slc18a3
T35106	24010-24016	PR_EXT:000003199	denotes	Camk2a
T35107	24033-24035	PR_EXT:000013773	denotes	Rb
T35108	24065-24069	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T35109	24079-24086	PR_EXT:000014968	denotes	Slc18a3
T35110	24137-24142	PR_EXT:000004968	denotes	Calb2
T35111	24144-24148	CL_GO_EXT:cell	denotes	cell
T35112	24144-24155	GO:0044297	denotes	cell bodies
T35113	24163-24166	UBERON:0001791	denotes	INL
T35114	24174-24181	PR_EXT:000014968	denotes	Slc18a3
T35115	24183-24187	CL_GO_EXT:cell	denotes	cell
T35116	24183-24194	GO:0044297	denotes	cell bodies
T35117	24200-24206	PR_EXT:000003199	denotes	Camk2a
T35118	24208-24212	CL_GO_EXT:cell	denotes	cell
T35119	24208-24219	GO:0044297	denotes	cell bodies
T35120	24227-24230	UBERON:0001791	denotes	INL
T35121	24283-24290	NCBITaxon:33208	denotes	animals
T35122	24347-24354	UBERON:0000966	denotes	retinas
T35123	24358-24360	SO_EXT:wild_type_entity_or_quality	denotes	WT
T35124	24379-24388	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T35976	28074-28078	PR_EXT:000006854	denotes	E2f3
T35977	28084-28091	SO_EXT:sequence_rescue_process	denotes	Rescues
T35978	28092-28107	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T35979	28111-28113	PR_EXT:000013773	denotes	Rb
T35980	28137-28144	UBERON:0000966	denotes	retinal
T35981	28180-28189	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T35982	28207-28213	GO:0005634	denotes	nuclei
T35983	28215-28219	CHEBI:51231	denotes	DAPI
T35984	28228-28235	GO:0007067	denotes	mitosis
T35985	28236-28242	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T35986	28260-28267	PR_EXT:000014968	denotes	Slc18a3
T35987	28281-28286	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marks
T35988	28291-28295	GO:0044297	denotes	soma
T35989	28316-28325	GO:0042995	denotes	processes
T35990	28356-28363	GO:0007067	denotes	mitotic
T35991	28369-28375	GO:0005634	denotes	nuclei
T35992	28379-28381	PR_EXT:000013773	denotes	Rb
T35993	28386-28388	PR_EXT:000013773	denotes	Rb
T35994	28389-28393	PR_EXT:000006853	denotes	E2f2
T35995	28403-28405	PR_EXT:000013773	denotes	Rb
T35996	28406-28410	PR_EXT:000006854	denotes	E2f3
T35997	28415-28422	UBERON:0000966	denotes	retinas
T35998	28424-28428	PR_EXT:000006852	denotes	E2f1
T35999	28434-28441	SO_EXT:sequence_rescue_process	denotes	rescues
T36000	28454-28461	GO:0007067	denotes	mitosis
T36001	28466-28470	CL_GO_EXT:cell	denotes	cell
T36002	28466-28476	GO:0008219	denotes	cell death
T36003	28510-28514	PR_EXT:000006853	denotes	E2f2
T36004	28535-28539	PR_EXT:000006854	denotes	E2f3
T36005	28554-28560	SO_EXT:sequence_rescue_process	denotes	rescue
T36006	28573-28580	GO:0007067	denotes	mitosis
T36007	28585-28589	CL_GO_EXT:cell	denotes	cell
T36008	28608-28615	SO_EXT:sequence_rescue_process	denotes	rescues
T36009	28645-28649	PR_EXT:000006852	denotes	E2f1
T36010	28654-28658	PR_EXT:000006854	denotes	E2f3
T36011	28668-28675	SO_EXT:sequence_rescue_process	denotes	rescues
T36012	28688-28695	GO:0007067	denotes	mitosis
T36013	28697-28701	CL_GO_EXT:cell	denotes	cell
T36014	28697-28707	GO:0008219	denotes	cell death
T36015	28746-28752	PR_EXT:000003199	denotes	Camk2a
T36016	28754-28759	CL_GO_EXT:cell	denotes	cells
T36017	28769-28773	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T36018	28780-28787	PR_EXT:000014968	denotes	Slc18a3
T36019	28800-28806	UBERON:0000966	denotes	retina
T36020	28826-28833	UBERON:0000966	denotes	retinal
T36021	28860-28866	GO:0005634	denotes	nuclei
T36022	28868-28872	CHEBI:51231	denotes	DAPI
T36023	28881-28888	PR_EXT:000014968	denotes	Slc18a3
T36024	28902-28906	PR_EXT:000009116	denotes	Isl1
T36025	28933-28941	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T36026	28942-28946	PR_EXT:000009116	denotes	Isl1
T36027	28948-28955	PR_EXT:000014968	denotes	Slc18a3
T36028	28957-28962	CL_GO_EXT:cell	denotes	cells
T36029	28976-28979	UBERON:0001791	denotes	INL
T36030	28999-29006	UBERON:0000966	denotes	retinal
T36031	29033-29042	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T36032	29060-29066	GO:0005634	denotes	nuclei
T36033	29068-29072	CHEBI:51231	denotes	DAPI
T36034	29081-29085	CL_GO_EXT:cell	denotes	cell
T36035	29081-29094	GO:0051301	denotes	cell division
T36036	29095-29101	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T36037	29102-29107	PR_EXT:000010425	denotes	Mki67
T36038	29121-29125	PR_EXT:000009116	denotes	Isl1
T36039	29152-29160	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T36040	29196-29200	PR_EXT:000009116	denotes	Isl1
T36041	29202-29207	CL_GO_EXT:cell	denotes	cells
T36042	29238-29245	UBERON:0000966	denotes	retinas
T36043	29265-29270	PR_EXT:000010425	denotes	Mki67
T36044	29325-29332	NCBITaxon:33208	denotes	animals
T36045	29389-29396	UBERON:0000966	denotes	retinas
T36046	29400-29402	SO_EXT:wild_type_entity_or_quality	denotes	WT
T36047	29421-29430	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T36739	34979-34983	PR_EXT:000006854	denotes	E2f3
T36740	34988-34990	PR_EXT:000013773	denotes	Rb
T36741	34991-35001	GO:0010467	denotes	Expression
T36742	35054-35061	UBERON:0000966	denotes	retinal
T36743	35088-35097	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T36744	35115-35119	PR_EXT:000006854	denotes	E2f3
T36745	35130-35134	CHEBI:51231	denotes	DAPI
T36746	35188-35192	PR_EXT:000006854	denotes	E2f3
T36747	35193-35197	SO_EXT:sequence_nullness	denotes	null
T36748	35198-35208	_FRAGMENT	denotes	peripheral
T36749	35227-35233	UBERON:0013682	denotes	retina
T36750	35213-35215	SO_EXT:wild_type_entity_or_quality	denotes	WT
T36751	35255-35259	PR_EXT:000006854	denotes	E2f3
T36752	35260-35267	CHEBI_PR_EXT:protein	denotes	protein
T36753	35286-35290	PR_EXT:000006854	denotes	E2f3
T36754	35294-35298	CL:0002672	denotes	RPCs
T36755	35312-35322	_FRAGMENT	denotes	peripheral
T36756	35329-35336	UBERON:0013682	denotes	retinal
T36757	35337-35344	CL:0000540	denotes	neurons
T36758	35374-35381	UBERON:0000966	denotes	retinal
T36759	35408-35417	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T36760	35435-35437	PR_EXT:000013773	denotes	Rb
T36761	35448-35452	CHEBI:51231	denotes	DAPI
T36762	35481-35483	PR_EXT:000013773	denotes	Rb
T36763	35484-35491	CHEBI_PR_EXT:protein	denotes	protein
T36764	35499-35509	_FRAGMENT	denotes	peripheral
T36765	35522-35529	UBERON:0013682	denotes	retinal
T36766	35510-35512	PR_EXT:000013773	denotes	Rb
T36767	35530-35537	CL:0000540	denotes	neurons
T36768	35543-35545	SO_EXT:wild_type_entity_or_quality	denotes	WT
T36769	35550-35557	UBERON:0000966	denotes	retinal
T36770	35584-35590	GO:0005634	denotes	nuclei
T36771	35592-35596	CHEBI:51231	denotes	DAPI
T36772	35605-35609	PR_EXT:000006854	denotes	E2f3
T36773	35619-35621	PR_EXT:000013773	denotes	Rb
T36774	35633-35637	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T36775	35643-35650	PR_EXT:000014968	denotes	Slc18a3
T36776	35683-35691	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T36777	35692-35696	GO:0044297	denotes	soma
T36778	35716-35725	GO:0042995	denotes	processes
T36779	35742-35750	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T37119	38878-38889	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	Subcellular
T37120	38881-38889	CL_GO_EXT:cell	denotes	cellular
T37121	38906-38910	PR_EXT:000006854	denotes	E2f3
T37122	38911-38919	SO_EXT:0001060	denotes	Isoforms
T37123	38930-38934	CL_GO_EXT:cell	denotes	Cell
T37124	38930-38940	GO:0007049	denotes	Cell Cycle
T37125	38941-38949	CHEBI_PR_EXT:protein	denotes	Proteins
T37126	38968-38974	UBERON:0000966	denotes	Retina
T37127	38975-38982	GO:0005634	denotes	Nuclear
T37128	38987-38998	GO:0005737	denotes	cytoplasmic
T37129	39037-39044	UBERON:0000966	denotes	retinal
T37130	39037-39050	CL:0009004	denotes	retinal cells
T37131	39045-39050	CL_GO_EXT:cell	denotes	cells
T37132	39056-39060	NCBITaxon:10088	denotes	mice
T37133	39078-39087	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T37134	39155-39163	CHEBI_PR_EXT:protein	denotes	proteins
T37135	39177-39182	PR_EXT:000028775	denotes	E2f3a
T37136	39182-39183	SO_EXT:sequence_nullness_or_absence	denotes	−
T37137	39184-39185	SO_EXT:sequence_nullness_or_absence	denotes	−
T37138	39186-39190	NCBITaxon:10088	denotes	mice
T37139	39240-39245	PR_EXT:000028775	denotes	E2f3a
T37140	39246-39253	CHEBI_PR_EXT:protein	denotes	protein
T37141	39255-39256	GO:0005737	denotes	C
T37142	39258-39269	GO:0005737	denotes	cytoplasmic
T37143	39280-39281	GO:0005634	denotes	N
T37144	39283-39290	GO:0005634	denotes	nuclear
T37834	39315-39320	PR_EXT:000028775	denotes	E2f3a
T37835	39321-39328	SO_EXT:0001060	denotes	Isoform
T37836	39340-39355	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T37837	39366-39368	PR_EXT:000013773	denotes	Rb
T37838	39407-39412	NCBITaxon:10088	denotes	mouse
T37839	39413-39415	SO_EXT:wild_type_entity_or_quality	denotes	WT
T37840	39417-39422	PR_EXT:000028775	denotes	E2f3a
T37841	39422-39423	SO_EXT:sequence_nullness_or_absence	denotes	−
T37842	39424-39425	SO_EXT:sequence_nullness_or_absence	denotes	−
T37843	39439-39449	GO_SO_EXT:sequence_rearrangement_process	denotes	recombined
T37844	39450-39456	SO:0000359	denotes	floxed
T37845	39457-39461	PR_EXT:000006854	denotes	E2f3
T37846	39486-39490	PR_EXT:000006854	denotes	E2f3
T37847	39490-39491	SO_EXT:sequence_nullness_or_absence	denotes	−
T37848	39492-39493	SO_EXT:sequence_nullness_or_absence	denotes	−
T37849	39511-39516	PR_EXT:000028775	denotes	E2f3a
T37850	39516-39517	SO_EXT:sequence_nullness_or_absence	denotes	−
T37851	39518-39519	SO_EXT:sequence_nullness_or_absence	denotes	−
T37852	39520-39524	NCBITaxon:10088	denotes	mice
T37853	39538-39542	PR_EXT:000006854	denotes	E2f3
T37854	39543-39547	SO_EXT:0000147	denotes	exon
T37855	39563-39569	SO_EXT:0000188	denotes	intron
T37856	39611-39618	SO_EXT:0000112	denotes	primers
T37857	39637-39642	PR_EXT:000028775	denotes	E2f3a
T37858	39642-39643	SO_EXT:normal_or_wild_type_or_present	denotes	+
T37859	39644-39645	SO_EXT:sequence_nullness_or_absence	denotes	−
T37860	39646-39651	NCBITaxon:10088	denotes	mouse
T37861	39679-39681	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T37862	39699-39704	PR_EXT:000028775	denotes	E2f3a
T37863	39715-39719	CHEBI_SO_EXT:mRNA	denotes	mRNA
T37864	39727-39733	UBERON:0000966	denotes	retina
T37865	39739-39748	SO_EXT:biological_sequence	denotes	sequences
T37866	39752-39759	SO_EXT:0000112	denotes	primers
T37867	39869-39871	SO_EXT:wild_type_entity_or_quality	denotes	WT
T37868	39872-39878	UBERON:0000966	denotes	retina
T37869	39879-39888	GO:0010467	denotes	expresses
T37870	39894-39899	PR_EXT:000028775	denotes	E2f3a
T37871	39910-39914	CHEBI_SO_EXT:mRNA	denotes	mRNA
T37872	39929-39934	PR_EXT:000028775	denotes	E2f3a
T37873	39934-39935	SO_EXT:sequence_nullness_or_absence	denotes	−
T37874	39936-39937	SO_EXT:sequence_nullness_or_absence	denotes	−
T37875	39938-39944	UBERON:0000966	denotes	retina
T37876	39951-39956	PR_EXT:000028775	denotes	E2f3a
T37877	39957-39961	CHEBI_SO_EXT:mRNA	denotes	mRNA
T37878	39972-39981	GO:0010467	denotes	expresses
T37879	39988-39992	CHEBI_SO_EXT:mRNA	denotes	mRNA
T37880	39994-39998	PR_EXT:000006854	denotes	E2f3
T37881	39998-39999	SO_EXT:sequence_nullness_or_absence	denotes	−
T37882	40000-40001	SO_EXT:sequence_nullness_or_absence	denotes	−
T37883	40002-40008	UBERON:0000966	denotes	retina
T37884	40027-40032	PR_EXT:000028775	denotes	E2f3a
T37885	40043-40048	CHEBI_SO_EXT:mRNA	denotes	mRNAs
T37886	40062-40071	GO:0010467	denotes	expresses
T37887	40074-40083	SO_EXT:sequence_truncation_process	denotes	truncated
T37888	40084-40088	CHEBI_SO_EXT:mRNA	denotes	mRNA
T37889	40097-40101	SO_EXT:0000147	denotes	exon
T37890	40119-40121	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T37891	40138-40141	PR_EXT:E2F	denotes	E2f
T37892	40142-40147	SO_EXT:0000704	denotes	genes
T37893	40154-40161	UBERON:0000966	denotes	retinas
T37894	40179-40188	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T37895	40241-40248	NCBITaxon:33208	denotes	animals
T37896	40306-40308	SO_EXT:wild_type_entity_or_quality	denotes	WT
T37897	40327-40336	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T37898	40394-40400	SO_EXT:sequence_rescue_process	denotes	Rescue
T37899	40404-40406	PR_EXT:000013773	denotes	Rb
T37900	40418-40423	PR_EXT:000028775	denotes	E2f3a
T37901	40424-40432	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T37902	40445-40452	UBERON:0000966	denotes	retinal
T37903	40479-40488	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T37904	40515-40521	GO:0005634	denotes	nuclei
T37905	40523-40527	CHEBI:51231	denotes	DAPI
T37906	40536-40543	GO:0000279	denotes	M-phase
T37907	40570-40576	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T37908	40577-40584	PR_EXT:000014968	denotes	Slc18a3
T37909	40592-40597	PR_EXT:000028775	denotes	E2f3a
T37910	40598-40606	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T37911	40647-40654	SO_EXT:sequence_rescue_process	denotes	rescues
T37912	40693-40694	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	M
T37913	40696-40705	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T37914	40711-40717	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T38522	47006-47008	PR_EXT:000013773	denotes	Rb
T38523	47009-47018	GO:0065007	denotes	Regulates
T38524	47046-47050	PR_EXT:000006852	denotes	E2f1
T38525	47055-47060	PR_EXT:000028775	denotes	E2f3a
T38526	47090-47092	PR_EXT:000013773	denotes	Rb
T38527	47190-47192	PR_EXT:000013773	denotes	Rb
T38528	47206-47208	PR_EXT:000013773	denotes	Rb
T38529	47235-47238	CL:0002672	denotes	RPC
T38530	47273-47288	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T38531	47292-47296	CL:0002672	denotes	RPCs
T38532	47357-47364	GO:0007067	denotes	mitosis
T38533	47398-47400	PR_EXT:000013773	denotes	Rb
T38534	47438-47442	PR_EXT:000006852	denotes	E2f1
T38535	47444-47446	PR_EXT:000013773	denotes	Rb
T38536	47472-47487	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T38537	47526-47531	PR_EXT:000028775	denotes	E2f3a
T38538	47566-47568	PR_EXT:000013773	denotes	Rb
T38539	47594-47609	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T38540	47619-47623	CL_GO_EXT:cell	denotes	cell
T18256	33321-33331	GO:0010467	denotes	expression
T18257	33335-33339	CL_GO_EXT:cell	denotes	cell
T18258	33366-33370	PR_EXT:000006854	denotes	E2f3
T18259	33432-33435	PR_EXT:E2F	denotes	E2f
T18260	33454-33459	NCBITaxon:10088	denotes	mouse
T18261	33460-33467	UBERON:0000479	denotes	tissues
T18262	33516-33520	PR_EXT:000006852	denotes	E2f1
T18263	33524-33528	PR_EXT:000006853	denotes	E2f2
T18264	33586-33590	PR_EXT:000006854	denotes	E2f3
T28336	54096-54101	NCBITaxon:10088	denotes	Mouse
T28337	54126-54130	NCBITaxon:10088	denotes	Mice
T28338	54202-54206	NCBITaxon:10088	denotes	mice
T28339	54219-54224	PR_EXT:000017355	denotes	Chx10
T28340	54229-54233	NCBITaxon:10088	denotes	mice
T28341	54246-54248	PR_EXT:000013773	denotes	Rb
T28342	54248-54252	SO_EXT:0000346	denotes	loxP
T21418	41683-41692	GO:0065007	denotes	Regulates
T18265	33591-33601	GO:0010467	denotes	expression
T18266	33621-33625	PR_EXT:000006854	denotes	E2f3
T18267	33642-33646	CL:0002672	denotes	RPCs
T24500	45977-45979	PR_EXT:000013773	denotes	Rb
T24501	45980-45988	GO:0065007	denotes	Controls
T24502	45993-46008	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T24503	46017-46022	PR_EXT:000028775	denotes	E2f3a
T24504	46037-46043	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T24505	46098-46105	UBERON:0000966	denotes	retinal
T24506	46106-46113	CL:0000540	denotes	neurons
T24507	46115-46119	PR_EXT:000006852	denotes	E2f1
T24508	46120-46128	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T24509	46157-46159	PR_EXT:000013773	denotes	Rb
T24510	46163-46174	CHEBI:15355	denotes	cholinergic
T18247	33128-33138	GO:0010467	denotes	Expression
T18248	33142-33146	PR_EXT:000006854	denotes	E2f3
T18249	33176-33179	UBERON:0001017	denotes	CNS
T18250	33176-33187	CL:0000117	denotes	CNS Neurons
T18251	33209-33213	PR_EXT:000006854	denotes	E2f3
T18252	33232-33247	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T18254	33278-33285	CL:0000540	denotes	neurons
T18268	33690-33703	GO:0008283	denotes	proliferation
T18269	33765-33769	PR_EXT:000006854	denotes	E2f3
T18270	33773-33790	UBERON:0013682	denotes	peripheral retina
T18271	33811-33817	UBERON:0000966	denotes	retina
T18272	33818-33832	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T18273	33837-33840	CL:0002672	denotes	RPC
T18324	35793-35797	PR_EXT:000006854	denotes	E2f3
T18325	35840-35847	CL:0000540	denotes	neurons
T18326	35859-35872	UBERON:0002616	denotes	brain regions
T18327	35915-35923	UBERON:0001876	denotes	amygdala
T18328	35925-35929	PR_EXT:000006854	denotes	E2f3
T18329	35932-35941	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T18330	35959-35967	CL:0000540	denotes	neuronal
T18331	35968-35975	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T18332	35976-35981	PR_EXT:000010124	denotes	Mtap2
T18333	35986-35991	PR_EXT:000010277	denotes	Mecp2
T18334	36011-36016	PR_EXT:000004968	denotes	Calb2
T18335	36024-36029	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marks
T18336	36042-36049	CL:0000540	denotes	neurons
T18337	36063-36068	CL:0000125	denotes	glial
T18338	36069-36075	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T18339	36076-36080	PR_EXT:000007939	denotes	Gfap
T18340	36109-36116	UBERON:0000966	denotes	retinal
T18341	36123-36127	PR_EXT:000006854	denotes	E2f3
T18342	36138-36147	GO:0010467	denotes	expressed
T18343	36151-36155	GO_PR_EXT:choline_O_acetyltransferase	denotes	Chat
T20150	38007-38014	GO:0005634	denotes	nuclear
T20141	37699-37709	GO:0010467	denotes	expressing
T20142	37710-37715	CL_GO_EXT:cell	denotes	cells
T20143	37723-37725	SO_EXT:wild_type_entity_or_quality	denotes	WT
T20144	37726-37733	UBERON:0000966	denotes	retinal
T20145	37734-37744	GO_PATO_EXT:biological_maturation	denotes	maturation
T20146	37778-37783	PR_EXT:000028775	denotes	E2f3a
T20147	37900-37905	PR_EXT:000028775	denotes	E2f3a
T20148	37926-37933	GO:0005634	denotes	nuclear
T20149	37938-37949	GO:0005737	denotes	cytoplasmic
T20151	38053-38062	GO_EXT:biological_movement_or_translocation_process	denotes	migrating
T20152	38063-38068	PR_EXT:000028775	denotes	E2f3a
T20153	38139-38148	GO_EXT:biological_movement_or_translocation_process	denotes	migrating
T20154	38173-38180	GO:0005634	denotes	nuclear
T20155	38220-38229	GO:0005737	denotes	cytoplasm
T20156	38266-38271	PR_EXT:000028775	denotes	E2f3a
T20157	38322-38327	PR_EXT:000028775	denotes	E2f3a
T20158	38331-38337	UBERON:0000966	denotes	retina
T20159	38363-38369	PR_EXT:000013042	denotes	Pou4f2
T20160	38373-38380	GO:0005634	denotes	nuclear
T20161	38381-38394	GO_EXT:transcription	denotes	transcription
T20162	38381-38401	GO_EXT:transcription_factor	denotes	transcription factor
T20163	38402-38411	GO:0010467	denotes	expressed
T20164	38415-38423	UBERON:0000045	denotes	ganglion
T20165	38415-38429	CL:0000740	denotes	ganglion cells
T20166	38424-38429	CL_GO_EXT:cell	denotes	cells
T20167	38443-38450	GO:0005634	denotes	nuclear
T20168	38451-38459	CHEBI_PR_EXT:protein	denotes	proteins
T20169	38485-38496	GO:0005737	denotes	cytoplasmic
T20170	38523-38530	PR_EXT:000014968	denotes	Slc18a3
T20171	38534-38545	GO:0005737	denotes	cytoplasmic
T20172	38550-38556	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T20173	38678-38683	PR_EXT:000028775	denotes	E2f3a
T20174	38723-38734	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T20175	38726-38734	CL_GO_EXT:cell	denotes	cellular
T20176	38780-38785	PR_EXT:000028775	denotes	E2f3a
T20177	38786-38798	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T20178	38806-38815	GO:0065007	denotes	regulated
T20179	38834-38866	GO_SO_EXT:post_translational_modification_entity_or_process	denotes	post-translational modifications
T20180	40762-40766	CL_GO_EXT:cell	denotes	cell
T20181	40762-40772	GO:0007049	denotes	cell cycle
T20182	40773-40783	GO_EXT:regulator	denotes	regulators
T20183	40791-40798	UBERON:0000966	denotes	retinal
T20184	40791-40810	GO:0060041	denotes	retinal development
T20185	40817-40822	PR_EXT:000028775	denotes	E2f3a
T20186	40824-40826	PR_EXT:000013773	denotes	Rb
T20187	40851-40853	SO_EXT:wild_type_entity_or_quality	denotes	WT
T20188	40854-40863	GO:0005737	denotes	cytoplasm
T20189	40868-40875	GO:0005634	denotes	nucleus
T20190	40914-40916	PR_EXT:000013773	denotes	Rb
T20191	40949-40956	GO:0005634	denotes	nuclear
T20192	40982-40993	GO:0005737	denotes	cytoplasmic
T20193	40994-40996	PR_EXT:000013773	denotes	Rb
T20194	41049-41051	PR_EXT:000013773	denotes	Rb
T20195	41068-41077	GO:0042995	denotes	processes
T20196	41141-41147	UBERON:0000966	denotes	retina
T20197	41154-41158	PR_EXT:000006852	denotes	E2f1
T20198	41185-41192	GO:0005634	denotes	nuclear
T20199	41197-41208	GO:0005737	denotes	cytoplasmic
T20200	41236-41241	PR_EXT:000028775	denotes	E2f3a
T20201	41263-41270	GO:0005634	denotes	nuclear
T6782	12817-12825	UBERON:0000045	denotes	ganglion
T6783	12830-12838	CL:0000561	denotes	amacrine
T6784	12894-12900	UBERON:0000966	denotes	retina
T6785	12908-12912	CHEBI:472552	denotes	BrdU
T6786	12914-12927	CL:0000210	denotes	photoreceptor
T6787	12998-13000	PR_EXT:000013773	denotes	Rb
T6788	13004-13011	UBERON:0000966	denotes	retinas
T6789	13077-13086	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T6790	13088-13090	SO_EXT:wild_type_entity_or_quality	denotes	WT
T6791	13092-13098	UBERON:0000966	denotes	retina
T6792	13160-13167	GO:0051320	denotes	S-phase
T6793	13168-13173	CL_GO_EXT:cell	denotes	cells
T6794	13272-13274	PR_EXT:000013773	denotes	Rb
T6856	15958-15967	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T6857	16012-16016	PR_EXT:000006852	denotes	E2f1
T6858	16034-16044	GO:0010467	denotes	expression
T6859	16054-16057	PR_EXT:E2F	denotes	E2f
T6860	16083-16088	SO_EXT:0000704	denotes	genes
T6861	16094-16102	GO:0065007	denotes	regulate
T6862	16107-16111	CL_GO_EXT:cell	denotes	cell
T6863	16107-16117	GO:0007049	denotes	cell cycle
T6864	16122-16131	GO:0006915	denotes	apoptosis
T6865	16164-16168	CL_GO_EXT:cell	denotes	cell
T6866	16164-16174	GO:0007049	denotes	cell cycle
T6867	16179-16188	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T6868	16189-16199	GO_EXT:regulator	denotes	regulators
T6869	16205-16217	GO_EXT:positive_regulation	denotes	up-regulated
T6870	16225-16227	PR_EXT:000013773	denotes	Rb
T6871	16231-16237	UBERON:0000966	denotes	retina
T6872	16261-16264	PR_EXT:E2F	denotes	E2f
T6873	16273-16277	PR_EXT:000006852	denotes	E2f1
T6874	16279-16283	PR_EXT:000006853	denotes	E2f2
T6875	16285-16290	PR_EXT:000028775	denotes	E2f3a
T6876	16296-16300	PR_EXT:000006858	denotes	E2f7
T6877	16324-16326	PR_EXT:000013773	denotes	Rb
T6878	16344-16348	PR_EXT:000006855	denotes	E2f4
T6879	16354-16358	PR_EXT:000006856	denotes	E2f5
T6880	16396-16400	CHEBI:472552	denotes	BrdU
T6881	16414-16418	CHEBI_EXT:dUTP	denotes	dUTP
T6882	16428-16437	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelling
T6883	16456-16460	PR_EXT:000006852	denotes	E2f1
T6884	16461-16469	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T6885	16502-16511	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T6886	16525-16529	PR_EXT:000006854	denotes	E2f3
T6887	16530-16538	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T13553	22675-22690	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T13554	22706-22710	CL_GO_EXT:cell	denotes	Cell
T13555	22706-22716	GO:0007049	denotes	Cell Cycle
T13556	22760-22773	CL:0000210	denotes	photoreceptor
T3642	6130-6138	GO:0065007	denotes	controls
T13568	23016-23018	PR_EXT:000013773	denotes	Rb
T13569	23019-23023	PR_EXT:000006852	denotes	E2f1
T13570	23028-23034	UBERON:0000966	denotes	retina
T13571	23060-23067	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T13572	23079-23083	CL_GO_EXT:cell	denotes	cell
T13573	23079-23089	GO:0007049	denotes	cell-cycle
T13574	23095-23104	GO:0006915	denotes	apoptosis
T13575	23117-23132	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T13576	23166-23171	PR_EXT:000004968	denotes	Calb2
T13577	23173-23183	PR_EXT:000004968	denotes	calretinin
T13578	23192-23197	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marks
T13579	23210-23218	_FRAGMENT	denotes	amacrine
T13580	23232-23236	CL:0000561	denotes	cell
T13581	23223-23231	UBERON:0000045	denotes	ganglion
T13582	23223-23236	CL:0000740	denotes	ganglion cell
T13583	23232-23243	GO:0044297	denotes	cell bodies
T13584	23291-23300	GO:0042995	denotes	processes
T13585	23332-23337	PR_EXT:000004968	denotes	Calb2
T13586	23363-23367	PR_EXT:000006852	denotes	E2f1
T13587	23411-23416	PR_EXT:000004968	denotes	Calb2
T13588	23443-23445	PR_EXT:000013773	denotes	Rb
T13589	23478-23485	SO_EXT:sequence_rescue_process	denotes	rescued
T13590	23493-23495	PR_EXT:000013773	denotes	Rb
T13591	23496-23500	PR_EXT:000006852	denotes	E2f1
T13592	23505-23511	UBERON:0000966	denotes	retina
T13593	23539-23544	PR_EXT:000004968	denotes	Calb2
T13594	23546-23550	CL_GO_EXT:cell	denotes	cell
T13595	23546-23557	GO:0044297	denotes	cell bodies
T13596	23565-23567	PR_EXT:000013773	denotes	Rb
T13597	23571-23574	UBERON:0001791	denotes	INL
T13598	23593-23606	CL:0000561	denotes	amacrine cell
T13599	23602-23606	CL_GO_EXT:cell	denotes	cell
T3643	6143-6147	CL_GO_EXT:cell	denotes	cell
T3597	4023-4037	CL:0000561	denotes	amacrine cells
T3598	4032-4037	CL_GO_EXT:cell	denotes	cells
T3599	4047-4060	CL:0000740	denotes	ganglion cell
T3600	4047-4066	UBERON:0001792	denotes	ganglion cell layer
T3601	4056-4060	CL_GO_EXT:cell	denotes	cell
T3602	4068-4071	UBERON:0001792	denotes	GCL
T3603	4090-4111	UBERON:0001790	denotes	outer plexiform layer
T3604	4113-4116	UBERON:0001790	denotes	OPL
T3605	4122-4143	UBERON:0001795	denotes	inner plexiform layer
T3606	4145-4148	UBERON:0001795	denotes	IPL
T3607	4156-4176	GO:0045202	denotes	synaptic connections
T3608	4192-4195	UBERON:0001789	denotes	ONL
T3609	4196-4199	UBERON:0001791	denotes	INL
T3610	4204-4207	UBERON:0001791	denotes	INL
T3611	4208-4211	UBERON:0001792	denotes	GCL
T3612	5901-5903	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	ti
T3613	5904-5905	CL:0000573	denotes	o
T3614	5908-5909	CL:0000745	denotes	s
T3615	5905-5908	_FRAGMENT	denotes	bla
T3616	5908-5909	CL:0000103	denotes	s
T3617	5908-5909	CL:0011107	denotes	s
T3618	5908-5909	CL:0000561	denotes	s
T3619	5908-5909	CL_GO_EXT:cell	denotes	s
T3620	5910-5911	UBERON:0000045	denotes	o
T3621	5910-5911	_FRAGMENT	denotes	o
T3622	5911-5914	CL:0000561	denotes	ma
T3623	5915-5916	GO:0065007	denotes	r
T3624	5916-5918	GO:0006915	denotes	ot
T3625	5927-5930	PR_EXT:000013773	denotes	is
T3626	5943-5947	CL_GO_EXT:cell	denotes	cell
T3627	5943-5953	GO:0007049	denotes	cell cycle
T3628	5966-5973	UBERON:0000966	denotes	retinal
T3629	5985-5989	CL_GO_EXT:cell	denotes	cell
T3630	5997-5999	PR_EXT:000013773	denotes	Rb
T3631	6031-6042	GO:0008283	denotes	proliferate
T3632	6069-6072	_FRAGMENT	denotes	rod
T3633	6096-6101	CL:0000604	denotes	cells
T3634	6074-6082	UBERON:0000045	denotes	ganglion
T3635	6074-6082	_FRAGMENT	denotes	ganglion
T3636	6096-6101	CL:0000740	denotes	cells
T3637	6088-6101	CL:0000103	denotes	bipolar cells
T3638	6096-6101	CL_GO_EXT:cell	denotes	cells
T3639	6103-6106	GO:0016265	denotes	die
T3640	6110-6119	GO:0006915	denotes	apoptosis
T3641	6127-6129	PR_EXT:000013773	denotes	Rb
R2305	T9057	T9056	_lexicallyChainedTo	cells,ganglion
R2306	T9058	T9055	_lexicallyChainedTo	rod cells,retinal
R2307	T9093	T9092	_lexicallyChainedTo	stage,embryonic
R2933	T10936	T10935	_lexicallyChainedTo	bipolar cells,rod
R2934	T10941	T10940	_lexicallyChainedTo	cells,activation of
R2935	T10951	T10950	_lexicallyChainedTo	cell,rod
R2936	T10952	T10950	_lexicallyChainedTo	apoptosis,rod
R3522	T13580	T13579	_lexicallyChainedTo	cell,amacrine
R3523	T13625	T13624	_lexicallyChainedTo	retina,peripheral
R3524	T13660	T13659	_lexicallyChainedTo	neurons,horizontal
R4451	T16255	T16254	_lexicallyChainedTo	death,cell
R4452	T16295	T16294	_lexicallyChainedTo	cell,bipolar
R5192	T18348	T18347	_lexicallyChainedTo	brain,regions of
R5193	T18349	T18347	_lexicallyChainedTo	spinal cord,regions of
R5194	T18352	T18351	_lexicallyChainedTo	neurons,cholinergic
R6612	T22875	T22874	_lexicallyChainedTo	Death,Cell
R6613	T22914	T22913	_lexicallyChainedTo	cells,bipolar
R6614	T22993	T22992	_lexicallyChainedTo	cells,development of
R6615	T22994	T22992	_lexicallyChainedTo	cells,development of
R7835	T26565	T26564	_lexicallyChainedTo	epithelia,gut
R7836	T26606	T26605	_lexicallyChainedTo	cells,division of
R9133	T30743	T30742	_lexicallyChainedTo	primer,forward
R9935	T33366	T33365	_lexicallyChainedTo	cells,horizontal
R9936	T33369	T33368	_lexicallyChainedTo	cells,bipolar
R9937	T33372	T33371	_lexicallyChainedTo	cells,Müller
R9938	T33375	T33374	_lexicallyChainedTo	cells,amacrine
R9939	T33381	T33380	_lexicallyChainedTo	cells,ganglion
R9940	T33381	T33383	_lexicallyChainedTo	cells,g
R10314	T34369	T34368	_lexicallyChainedTo	Cells,Ganglion
R10315	T34371	T34370	_lexicallyChainedTo	Cells,Rod
R11103	T36749	T36748	_lexicallyChainedTo	retina,peripheral
R11104	T36756	T36755	_lexicallyChainedTo	retinal,peripheral
R11105	T36765	T36764	_lexicallyChainedTo	retinal,peripheral
R283	T3596	T3595	_lexicallyChainedTo	cells,ganglion
R284	T3616	T3615	_lexicallyChainedTo	s,bla
R286	T3633	T3632	_lexicallyChainedTo	cells,rod
R287	T3636	T3635	_lexicallyChainedTo	cells,ganglion
R288	T3787	T3786	_lexicallyChainedTo	cells,differentiation of
R5	T568	T567	_lexicallyChainedTo	neurons,death of
R6	T573	T572	_lexicallyChainedTo	cells,responses in
R7	T582	T581	_lexicallyChainedTo	1,E2f transcription factor
R8	T582	T585	_lexicallyChainedTo	1,E2f
R275	T3562	T3561	_lexicallyChainedTo	proliferation,cell
R280	T3584	T3583	_lexicallyChainedTo	cells,horizontal
R282	T3586	T3585	_lexicallyChainedTo	cells,bipolar
R1516	T6826	T6825	_lexicallyChainedTo	cells,bipolar
R1517	T6835	T6834	_lexicallyChainedTo	cells,death of
R1518	T6838	T6837	_lexicallyChainedTo	neurons,bipolar
R2302	T9023	T9022	_lexicallyChainedTo	segments,inner
R2303	T9054	T9053	_lexicallyChainedTo	cells,retinal bipolar
R2304	T9056	T9055	_lexicallyChainedTo	ganglion,retinal

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T510	0-2	PR:000013773	denotes	Rb
T511	12-20	CL:0000540	denotes	Neuronal
T512	45-55	GO:0007049	denotes	Cell-Cycle
T513	68-78	GO:0065007	denotes	Regulation
T514	82-87	PR:000028775	denotes	E2f3a
T515	177-199	PR:000013773	denotes	retinoblastoma protein
T516	201-203	PR:000013773	denotes	Rb
T517	290-292	PR:000013773	denotes	Rb
T518	309-319	GO:0007049	denotes	cell cycle
T519	338-346	_FRAGMENT	denotes	death of
T520	352-359	GO:0070997	denotes	neurons
T521	352-359	CL:0000540	denotes	neurons
T522	507-519	_FRAGMENT	denotes	responses in
T523	541-546	GO:0051716	denotes	cells
T524	520-522	PR:000013773	denotes	Rb
T525	533-540	UBERON:0000966	denotes	retinal
T526	533-546	CL:0009004	denotes	retinal cells
T527	585-594	GO:0006915	denotes	apoptosis
T528	632-656	_FRAGMENT	denotes	E2f transcription factor
T529	663-664	PR:000006852	denotes	1
T530	658-661	_FRAGMENT	denotes	E2f
T531	735-741	UBERON:0000966	denotes	retina
T532	750-760	GO:0007049	denotes	cell-cycle
T533	823-837	CL:0000561	denotes	amacrine cells
T534	846-857	CHEBI:15355	denotes	cholinergic
T535	858-870	CL:0000099	denotes	interneurons
T536	963-965	PR:000013773	denotes	Rb
T537	1062-1068	UBERON:0000479	denotes	tissue
T538	1108-1110	PR:000013773	denotes	Rb
T539	1154-1158	PR:000006854	denotes	E2f3
T540	1173-1177	PR:000006854	denotes	E2f3
T541	1178-1186	SO:0001060	denotes	isoforms
T542	1229-1235	UBERON:0000966	denotes	retina
T543	1332-1334	PR:000013773	denotes	Rb
T544	1347-1356	GO:0044838	denotes	quiescent
T545	1431-1438	SO:0001060	denotes	isoform
T546	1469-1471	PR:000013773	denotes	Rb
T547	1509-1514	PR:000028775	denotes	E2f3a
T548	1560-1562	PR:000013773	denotes	Rb
T549	1563-1572	GO:0065007	denotes	regulates
T550	1651-1656	PR:000028775	denotes	E2f3a
T551	1678-1684	UBERON:0000479	denotes	tissue
T3387	5904-5905	CL:0000573	denotes	o
T3388	5908-5909	CL:0000745	denotes	s
T3389	5905-5908	_FRAGMENT	denotes	bla
T3390	5908-5909	CL:0000103	denotes	s
T3391	5908-5909	CL:0011107	denotes	s
T3392	5908-5909	CL:0000561	denotes	s
T3374	4023-4037	CL:0000561	denotes	amacrine cells
T3375	4047-4060	CL:0000740	denotes	ganglion cell
T3376	4047-4066	UBERON:0001792	denotes	ganglion cell layer
T3377	4068-4071	UBERON:0001792	denotes	GCL
T3378	4090-4111	UBERON:0001790	denotes	outer plexiform layer
T3379	4113-4116	UBERON:0001790	denotes	OPL
T3380	4122-4143	UBERON:0001795	denotes	inner plexiform layer
T3381	4145-4148	UBERON:0001795	denotes	IPL
T3382	4156-4176	GO:0045202	denotes	synaptic connections
T3383	4192-4195	UBERON:0001789	denotes	ONL
T3384	4196-4199	UBERON:0001791	denotes	INL
T3385	4204-4207	UBERON:0001791	denotes	INL
T3386	4208-4211	UBERON:0001792	denotes	GCL
T3393	5910-5911	UBERON:0000045	denotes	o
T3394	5910-5911	_FRAGMENT	denotes	o
T3417	6347-6357	GO:0007049	denotes	cell cycle
T3418	6451-6455	PR:000006852	denotes	E2f1
T3419	6457-6461	PR:000006853	denotes	E2f2
T3420	6467-6472	PR:000028775	denotes	E2f3a
T3421	6517-6527	CL:0000057	denotes	fibroblast
T3422	6599-6610	CL:0000057	denotes	fibroblasts
T3423	6655-6657	PR:000013773	denotes	Rb
T3424	6685-6687	PR:000013773	denotes	Rb
T3425	6691-6698	UBERON:0000922	denotes	embryos
T3426	6746-6753	UBERON:0000479	denotes	tissues
T3427	6770-6774	PR:000006852	denotes	E2f1
T3428	6776-6780	PR:000006853	denotes	E2f2
T3429	6785-6789	PR:000006854	denotes	E2f3
T3430	6835-6837	PR:000013773	denotes	Rb
T3431	6895-6899	PR:000006855	denotes	E2f4
T3432	6904-6908	PR:000006856	denotes	E2f5
T3433	7013-7017	SO:0000704	denotes	gene
T3434	7013-7027	GO:0016458	denotes	gene silencing
T3435	7031-7040	GO:0044838	denotes	quiescent
T3436	7099-7108	GO:0006915	denotes	apoptosis
T3437	7116-7118	PR:000013773	denotes	Rb
T3438	7122-7128	UBERON:0000966	denotes	retina
T3439	7154-7158	PR:000006852	denotes	E2f1
T3440	7292-7296	PR:000006852	denotes	E2f1
T3441	7300-7304	PR:000006854	denotes	E2f3
T3442	7322-7331	GO:0006915	denotes	apoptosis
T3443	7350-7372	UBERON:0001017	denotes	central nervous system
T3444	7374-7377	UBERON:0001017	denotes	CNS
T3445	7382-7384	PR:000013773	denotes	Rb
T3446	7388-7395	UBERON:0000922	denotes	embryos
T3447	7418-7421	UBERON:0001017	denotes	CNS
T3448	7422-7431	GO:0006915	denotes	apoptosis
T3449	7470-7479	UBERON:0001987	denotes	placental
T3450	7526-7530	PR:000006854	denotes	E2f3
T3451	7539-7548	GO:0006915	denotes	apoptosis
T3452	7552-7563	CL:0000057	denotes	fibroblasts
T3453	7599-7603	PR:000006852	denotes	E2f1
T3454	7644-7648	PR:000006854	denotes	E2f3
T3455	7665-7674	GO:0006915	denotes	apoptosis
T3456	7682-7684	PR:000013773	denotes	Rb
T3457	7741-7746	GO:0016265	denotes	death
T3458	7759-7761	PR:000013773	denotes	Rb
T3459	7765-7772	UBERON:0000479	denotes	tissues
T3460	7826-7828	PR:000013773	denotes	Rb
T3461	7929-7933	PR:000006854	denotes	E2f3
T3462	7934-7942	SO:0001060	denotes	isoforms
T3463	7956-7965	SO:0000167	denotes	promoters
T3464	8040-8045	SO:0000147	denotes	exons
T3465	8052-8057	PR:000028775	denotes	E2f3a
T3466	8118-8128	GO:0010467	denotes	expression
T3467	8145-8154	GO:0044838	denotes	quiescent
T3468	8240-8249	GO:0044838	denotes	quiescent
T3469	8277-8286	GO:0044838	denotes	quiescent
T3470	8287-8298	CL:0000057	denotes	fibroblasts
T3471	8328-8330	PR:000013773	denotes	Rb
T3472	8388-8397	GO:0016458	denotes	silencing
T3473	8402-8408	PR:000005279	denotes	Cdkn2d
T3474	8410-8416	PR:000005279	denotes	p19Arf
T3475	8495-8503	SO:0001060	denotes	isoforms
T3476	8559-8563	PR:000006852	denotes	E2f1
T3477	8568-8572	PR:000006853	denotes	E2f2
T3478	8596-8604	SO:0001060	denotes	isoforms
T3479	8640-8649	GO:0065007	denotes	regulated
T3480	8823-8831	SO:0001060	denotes	isoforms
T3481	8895-8897	PR:000013773	denotes	Rb
T3482	8912-8920	CL:0000540	denotes	neuronal
T3483	9089-9094	GO:0016265	denotes	death
T3484	9099-9101	PR:000013773	denotes	Rb
T3485	9107-9115	GO:0065007	denotes	regulate
T3486	9196-9203	CL:0000540	denotes	neurons
T3487	9278-9280	PR:000013773	denotes	Rb
T3488	9408-9414	UBERON:0000479	denotes	tissue
T3489	9474-9480	UBERON:0000966	denotes	retina
T3490	9518-9520	PR:000013773	denotes	Rb
T3491	9524-9528	CL:0000604	denotes	rods
T3492	9548-9550	PR:000013773	denotes	Rb
T3493	9578-9591	GO:0009653	denotes	morphogenesis
T3494	9606-9612	UBERON:0000966	denotes	retina
T3495	9676-9678	PR:000013773	denotes	Rb
T3496	9682-9688	CL:0000540	denotes	neuron
T3497	9744-9753	GO:0006915	denotes	apoptosis
T3498	9797-9815	_FRAGMENT	denotes	differentiation of
T3499	9822-9827	GO:0030154	denotes	cells
T3500	9816-9818	PR:000013773	denotes	Rb
T3501	9854-9867	GO:0008283	denotes	proliferation
T3502	9872-9877	GO:0016265	denotes	death
T3503	9903-9905	PR:000013773	denotes	Rb
T3504	9934-9939	GO:0016265	denotes	death
T3505	9954-9958	PR:000006852	denotes	E2f1
T3506	9964-9968	PR:000006853	denotes	E2f2
T3507	9972-9976	PR:000006854	denotes	E2f3
T3508	10016-10023	UBERON:0000966	denotes	retinal
T3509	10024-10031	CL:0000540	denotes	neurons
T3510	10043-10047	CL:0000604	denotes	rods
T3511	10120-10126	UBERON:0000966	denotes	retina
T3512	10186-10188	PR:000013773	denotes	Rb
T3513	10231-10233	PR:000013773	denotes	Rb
T3514	10234-10238	PR:000006852	denotes	E2f1
T3515	10259-10265	UBERON:0000966	denotes	retina
T3516	10303-10314	CHEBI:15355	denotes	cholinergic
T3517	10325-10339	CL:0000561	denotes	amacrine cells
T3518	10394-10406	CL:0000099	denotes	interneurons
T3519	10591-10593	PR:000013773	denotes	Rb
T3520	10643-10649	UBERON:0000479	denotes	tissue
T3521	10695-10697	PR:000013773	denotes	Rb
T3522	10734-10738	PR:000006854	denotes	E2f3
T3523	10751-10753	PR:000013773	denotes	Rb
T3524	10789-10793	PR:000006854	denotes	E2f3
T3525	10794-10804	GO:0010467	denotes	expression
T3526	10825-10829	PR:000006854	denotes	E2f3
T3527	10830-10840	GO:0010467	denotes	expression
T3528	10855-10862	CL:0000540	denotes	neurons
T3529	10891-10893	PR:000013773	denotes	Rb
T3530	10895-10899	PR:000006854	denotes	E2f3
T3531	10946-10949	UBERON:0001017	denotes	CNS
T3532	10946-10957	CL:0000117	denotes	CNS neurons
T3533	11014-11016	PR:000013773	denotes	Rb
T3534	11029-11041	GO:0022008	denotes	neurogenesis
T3535	11108-11112	PR:000006854	denotes	E2f3
T3536	11113-11120	SO:0001060	denotes	isoform
T3537	11121-11123	PR:000013773	denotes	Rb
T3538	11135-11142	GO:0065007	denotes	control
T3539	11179-11181	PR:000013773	denotes	Rb
T3540	11194-11203	GO:0044838	denotes	quiescent
T3541	11204-11215	CL:0000057	denotes	fibroblasts
T3542	11275-11280	PR:000028775	denotes	E2f3a
T3543	11318-11325	SO:0001060	denotes	isoform
T3544	11340-11345	NCBITaxon:10088	denotes	mouse
T3545	11359-11361	PR:000013773	denotes	Rb
T3546	11397-11402	PR:000028775	denotes	E2f3a
T3547	11425-11429	PR:000006852	denotes	E2f1
T3548	11463-11468	GO:0016265	denotes	death
T3549	11470-11472	PR:000013773	denotes	Rb
T3550	11478-11486	GO:0065007	denotes	regulate
T3551	11487-11495	CL:0000540	denotes	neuronal
T3552	11534-11541	CL:0000540	denotes	neurons
T3553	11569-11574	PR:000028775	denotes	E2f3a
T3554	11580-11586	UBERON:0000479	denotes	tissue
T6616	12279-12283	PR:000006853	denotes	E2f2
T6617	12287-12291	PR:000006854	denotes	E2f3
T6618	12318-12320	PR:000013773	denotes	Rb
T6619	12325-12329	PR:000006854	denotes	E2f3
T6620	12330-12337	SO:0001023	denotes	alleles
T6621	12345-12351	UBERON:0000966	denotes	retina
T6622	12423-12436	GO:0051301	denotes	cell division
T6623	12438-12442	NCBITaxon:10088	denotes	mice
T6624	12468-12485	CHEBI:472552	denotes	bromodeoxyuridine
T6625	12487-12491	CHEBI:472552	denotes	BrdU
T6626	12522-12539	UBERON:0013682	denotes	peripheral retina
T6627	12553-12557	CHEBI:472552	denotes	BrdU
T6628	12621-12623	PR:000013773	denotes	Rb
T6575	11631-11633	PR:000013773	denotes	Rb
T6576	11634-11643	GO:0065007	denotes	Regulates
T6577	11657-11662	GO:0016265	denotes	Death
T6578	11671-11675	PR:000006852	denotes	E2f1
T6579	11694-11703	SO:0000902	denotes	transgene
T6580	11714-11720	SO:0000359	denotes	floxed
T6581	11721-11723	PR:000013773	denotes	Rb
T6582	11724-11728	SO:0000147	denotes	exon
T6583	11735-11744	UBERON:0000922	denotes	embryonic
T6584	11759-11776	UBERON:0013682	denotes	peripheral retina
T6585	11782-11784	PR:000013773	denotes	Rb
T6586	11784-11788	SO:0000346	denotes	loxP
T6587	11789-11793	SO:0000346	denotes	loxP
T6588	11800-11804	NCBITaxon:10088	denotes	mice
T6589	11836-11840	PR:000006852	denotes	E2f1
T6590	11844-11848	PR:000006853	denotes	E2f2
T6591	11890-11896	SO:0000359	denotes	floxed
T6592	11897-11901	PR:000006854	denotes	E2f3
T6593	11902-11908	SO:0001023	denotes	allele
T6594	11914-11916	PR:000013773	denotes	Rb
T6595	11916-11920	SO:0000346	denotes	loxP
T6596	11921-11925	SO:0000346	denotes	loxP
T6597	11926-11930	PR:000006852	denotes	E2f1
T6598	11938-11940	PR:000013773	denotes	Rb
T6599	11940-11944	SO:0000346	denotes	loxP
T6600	11945-11949	SO:0000346	denotes	loxP
T6601	11950-11954	PR:000006852	denotes	E2f1
T6602	11964-11968	NCBITaxon:10088	denotes	mice
T6603	11990-11992	PR:000013773	denotes	Rb
T6604	11992-11996	SO:0000346	denotes	loxP
T6605	11997-12001	SO:0000346	denotes	loxP
T6606	12002-12006	PR:000006852	denotes	E2f1
T6607	12016-12020	NCBITaxon:10088	denotes	mice
T6608	12142-12144	PR:000013773	denotes	Rb
T6609	12144-12148	SO:0000346	denotes	loxP
T6610	12149-12153	SO:0000346	denotes	loxP
T6611	12154-12158	PR:000006852	denotes	E2f1
T6612	12168-12185	UBERON:0013682	denotes	peripheral retina
T6613	12193-12195	PR:000013773	denotes	Rb
T6614	12196-12200	PR:000006852	denotes	E2f1
T6615	12223-12229	UBERON:0000966	denotes	retina
T6629	12627-12634	UBERON:0000966	denotes	retinas
T6630	12679-12692	GO:0071897	denotes	DNA synthesis
T6631	12760-12765	GO:0007567	denotes	natal
T6632	12789-12795	UBERON:0000966	denotes	retina
T6633	12811-12815	CHEBI:472552	denotes	BrdU
T6670	14085-14089	CL:0000604	denotes	rods
T6671	14124-14126	PR:000013773	denotes	Rb
T6672	14130-14134	CL:0000604	denotes	rods
T6673	14163-14166	UBERON:0001789	denotes	ONL
T6674	14176-14184	_FRAGMENT	denotes	death of
T6675	14191-14196	GO:0008219	denotes	cells
T6676	14208-14215	_FRAGMENT	denotes	bipolar
T6677	14229-14236	CL:0000103	denotes	neurons
T6678	14220-14228	UBERON:0000045	denotes	ganglion
T6679	14220-14236	CL:0000740	denotes	ganglion neurons
T6680	14387-14389	PR:000013773	denotes	Rb
T6681	14393-14401	UBERON:0000045	denotes	ganglion
T6682	14393-14407	CL:0000740	denotes	ganglion cells
T6683	14445-14450	UBERON:0000970	denotes	optic
T6684	14503-14507	PR:000006852	denotes	E2f1
T6685	14517-14521	PR:000006853	denotes	E2f2
T6686	14525-14529	PR:000006854	denotes	E2f3
T6687	14552-14562	GO:0008219	denotes	cell death
T8816	16597-16599	PR:000013773	denotes	Rb
T8817	16600-16604	PR:000006852	denotes	E2f1
T8818	16609-16615	UBERON:0000966	denotes	Retina
T8819	16624-16628	PR:000006852	denotes	E2f1
T8820	16667-16672	GO:0016265	denotes	death
T8821	16680-16682	PR:000013773	denotes	Rb
T8822	16686-16692	UBERON:0000966	denotes	retina
T8823	16698-16700	PR:000013773	denotes	Rb
T8824	16701-16705	PR:000006852	denotes	E2f1
T8825	16710-16716	UBERON:0000966	denotes	retina
T8826	16767-16769	PR:000013773	denotes	Rb
T8827	16770-16778	GO:0065007	denotes	controls
T8828	16810-16820	GO:0007049	denotes	cell cycle
T8829	16834-16836	PR:000013773	denotes	Rb
T8830	16837-16841	PR:000006852	denotes	E2f1
T8831	16846-16852	UBERON:0000966	denotes	retina
T8832	16862-16865	PR:000014434	denotes	Sag
T8833	16868-16877	PR:000014434	denotes	S-antigen
T8834	16870-16877	CHEBI:59132	denotes	antigen
T8835	16878-16881	CL:0000604	denotes	rod
T8836	16878-16890	PR:000014434	denotes	rod arrestin
T8837	16892-16906	CL:0000210	denotes	photoreceptors
T8838	16908-16914	PR:000013042	denotes	Pou4f2
T8839	16917-16922	PR:000013042	denotes	Brn3b
T8840	16924-16932	UBERON:0000045	denotes	ganglion
T8841	16924-16938	CL:0000740	denotes	ganglion cells
T8842	16953-16958	PR:000003058	denotes	Prkca
T8843	16960-16965	PR:000004937	denotes	Cabp5
T8844	16967-16982	CL:0000103	denotes	bipolar neurons
T8845	17054-17056	PR:000013773	denotes	Rb
T8846	17057-17061	PR:000006853	denotes	E2f2
T8847	17065-17067	PR:000013773	denotes	Rb
T8848	17068-17072	PR:000006854	denotes	E2f3
T8849	17077-17084	UBERON:0000966	denotes	retinas
T8850	17120-17128	CL:0000540	denotes	neuronal
T8851	17137-17142	PR:000010124	denotes	Mtap2
T8852	17144-17148	PR:000010124	denotes	MAP2
T8853	17154-17160	PR:000015312	denotes	Snap25
T8854	17187-17196	GO:0010467	denotes	expressed
T8855	17200-17213	CL:0000103	denotes	bipolar cells
T8856	17215-17220	PR:000017355	denotes	Chx10
T8857	17222-17227	PR:000013845	denotes	Rcvrn
T8858	17229-17233	PR:000017354	denotes	Vsx1
T8859	17235-17240	PR:000001242	denotes	Tacr3
T8860	17246-17252	PR:000004445	denotes	Atp2b1
T8861	17258-17276	CL:0000604	denotes	rod photoreceptors
T8862	17278-17281	PR:000001245	denotes	Rho
T8863	17286-17291	PR:000013845	denotes	Rcvrn
T8864	17317-17319	PR:000013773	denotes	Rb
T8865	17320-17324	PR:000006852	denotes	E2f1
T8866	17329-17335	UBERON:0000966	denotes	retina
T8867	17358-17365	CL:0000540	denotes	neurons
T8868	17413-17419	UBERON:0000966	denotes	retina
T8869	17421-17433	CL:0000103	denotes	Bipolar cell
T8870	17429-17440	GO:0044297	denotes	cell bodies
T8871	17461-17464	UBERON:0001791	denotes	INL
T8872	17498-17507	GO:0042995	denotes	processes
T8873	17578-17580	PR:000013773	denotes	Rb
T8874	17581-17585	PR:000006852	denotes	E2f1
T8875	17590-17596	UBERON:0000966	denotes	retina
T8876	17621-17624	UBERON:0001789	denotes	ONL
T8877	17662-17666	CL:0000604	denotes	rods
T8878	17683-17692	GO:0042995	denotes	processes
T8879	17725-17734	GO:0042995	denotes	processes
T8880	17754-17759	_FRAGMENT	denotes	inner
T8881	17770-17778	GO:0001917	denotes	segments
T8882	17764-17778	GO:0001750	denotes	outer segments
T8883	17814-17816	PR:000013773	denotes	Rb
T8884	17823-17831	GO:0065007	denotes	regulate
T8885	17832-17845	CL:0000210	denotes	photoreceptor
T8886	17880-17883	CL:0000604	denotes	rod
T8887	17945-17947	PR:000013773	denotes	Rb
T8888	17953-17961	GO:0065007	denotes	regulate
T8889	17962-17975	CL:0000210	denotes	photoreceptor
T8890	18018-18022	PR:000006852	denotes	E2f1
T8891	18044-18047	CL:0000604	denotes	rod
T8892	18081-18085	PR:000012086	denotes	Otx2
T8893	18087-18090	PR:000005904	denotes	Crx
T8894	18095-18098	PR:000011432	denotes	Nrl
T8895	18133-18137	PR:000006852	denotes	E2f1
T8896	18190-18200	GO:0010467	denotes	expression
T8897	18204-18209	SO:0000704	denotes	genes
T8898	18215-18223	GO:0065007	denotes	modulate
T8899	18277-18290	GO:0008283	denotes	proliferation
T8900	18346-18355	GO:0006915	denotes	apoptosis
T8901	18390-18392	PR:000013773	denotes	Rb
T8902	18396-18403	UBERON:0000966	denotes	retinal
T8903	18396-18411	_FRAGMENT	denotes	retinal bipolar
T8904	18431-18436	CL:0000748	denotes	cells
T8905	18396-18403	_FRAGMENT	denotes	retinal
T8906	18413-18421	_FRAGMENT	denotes	ganglion
T8907	18431-18436	CL:0000740	denotes	cells
T8908	18427-18436	CL:0000604	denotes	rod cells
T8909	18413-18421	UBERON:0000045	denotes	ganglion
T8910	18454-18458	PR:000006852	denotes	E2f1
T8911	18534-18536	PR:000013773	denotes	Rb
T8912	18546-18550	PR:000006852	denotes	E2f1
T8913	18572-18575	CL:0002672	denotes	RPC
T8914	18606-18609	CL:0002672	denotes	RPC
T8915	18610-18623	GO:0008283	denotes	proliferation
T8916	18700-18703	CL:0002672	denotes	RPC
T8917	18730-18734	PR:000006852	denotes	E2f1
T8918	18786-18794	UBERON:0000045	denotes	ganglion
T8919	18786-18800	CL:0000740	denotes	ganglion cells
T8920	18825-18838	CL:0000103	denotes	bipolar cells
T8921	18882-18885	UBERON:0001789	denotes	ONL
T8922	18907-18911	PR:000006852	denotes	E2f1
T8923	18919-18921	PR:000013773	denotes	Rb
T8924	18922-18926	PR:000006852	denotes	E2f1
T8925	18931-18937	UBERON:0000966	denotes	retina
T8926	18972-18976	PR:000006852	denotes	E2f1
T8927	18980-18987	CL:0000540	denotes	neurons
T8928	19074-19076	PR:000013773	denotes	Rb
T8929	19077-19081	PR:000006852	denotes	E2f1
T8930	19090-19094	PR:000006852	denotes	E2f1
T8931	19098-19111	CL:0000103	denotes	bipolar cells
T8932	19208-19213	GO:0016265	denotes	death
T8933	19249-19258	GO:0006915	denotes	apoptosis
T8934	19283-19288	GO:0007567	denotes	natal
T8935	19313-19315	PR:000013773	denotes	Rb
T8936	19316-19320	PR:000006852	denotes	E2f1
T8937	19325-19331	UBERON:0000966	denotes	retina
T8938	19377-19382	PR:000005121	denotes	Ccnd1
T8939	19407-19409	PR:000013773	denotes	Rb
T8940	19433-19436	CL:0002672	denotes	RPC
T8941	19485-19487	PR:000013773	denotes	Rb
T8942	19491-19497	UBERON:0000966	denotes	retina
T8943	19558-19561	CL:0002672	denotes	RPC
T8944	19612-19614	PR:000013773	denotes	Rb
T8945	19674-19678	PR:000006852	denotes	E2f1
T10820	20120-20124	NCBITaxon:10088	denotes	mice
T10821	20151-20168	GO:0007602	denotes	visual signalling
T10822	20176-20185	NCBITaxon:40674	denotes	mammalian
T10823	20186-20192	UBERON:0000966	denotes	retina
T10824	20198-20212	CL:0000210	denotes	photoreceptors
T10825	20216-20230	CL:0000561	denotes	amacrine cells
T10826	20248-20255	UBERON:0000045	denotes	gangion
T10827	20248-20261	CL:0000740	denotes	gangion cells
T10828	20285-20288	_FRAGMENT	denotes	rod
T10803	19704-19706	PR:000013773	denotes	Rb
T10804	19707-19711	PR:000006852	denotes	E2f1
T10805	19716-19722	UBERON:0000966	denotes	Retina
T10806	19742-19746	PR:000006852	denotes	E2f1
T10807	19783-19785	PR:000013773	denotes	Rb
T10808	19789-19796	CL:0000540	denotes	neurons
T10809	19819-19821	PR:000013773	denotes	Rb
T10810	19836-19844	GO:0065007	denotes	regulate
T10811	20044-20049	UBERON:0007023	denotes	adult
T10812	20062-20066	PR:000006852	denotes	E2f1
T10813	20077-20079	PR:000013773	denotes	Rb
T10814	20079-20083	SO:0000346	denotes	loxP
T10815	20084-20088	SO:0000346	denotes	loxP
T10816	20100-20102	PR:000013773	denotes	Rb
T10817	20102-20106	SO:0000346	denotes	loxP
T10818	20107-20111	SO:0000346	denotes	loxP
T10819	20112-20116	PR:000006852	denotes	E2f1
T10829	20298-20311	CL:0000751	denotes	bipolar cells
T10830	20293-20311	CL:0000752	denotes	cone bipolar cells
T10831	20389-20403	CL:0000210	denotes	photoreceptors
T10832	20480-20493	_FRAGMENT	denotes	activation of
T10833	20505-20510	GO:0001775	denotes	cells
T10834	20494-20510	CL:0000749	denotes	ON bipolar cells
T10835	20551-20563	GO:1990603	denotes	dark-adapted
T10836	20565-20573	GO:1990603	denotes	scotopic
T10837	20610-20613	CL:0000604	denotes	rod
T10838	20648-20650	PR:000013773	denotes	Rb
T10839	20654-20660	UBERON:0000966	denotes	retina
T10840	20742-20745	_FRAGMENT	denotes	rod
T10841	20758-20762	CL:0000604	denotes	cell
T10842	20763-20772	GO:0097473	denotes	apoptosis
T10843	20750-20762	CL:0000103	denotes	bipolar cell
T10844	20758-20772	GO:0006915	denotes	cell apoptosis
T10845	20897-20903	UBERON:0000966	denotes	retina
T10846	20949-20953	PR:000006852	denotes	E2f1
T10847	20957-20963	UBERON:0000966	denotes	retina
T10848	20997-20999	PR:000013773	denotes	Rb
T10849	21000-21004	PR:000006852	denotes	E2f1
T10850	21106-21110	PR:000006852	denotes	E2f1
T10851	21150-21153	CL:0000604	denotes	rod
T10852	21168-21170	PR:000013773	denotes	Rb
T10853	21174-21180	UBERON:0000966	denotes	retina
T10854	21182-21195	GO:0036367	denotes	Light-adapted
T10855	21197-21205	GO:0036367	denotes	photopic
T10856	21245-21249	CL:0000573	denotes	cone
T10857	21285-21290	CL:0000573	denotes	Cones
T10858	21312-21326	CL:0000210	denotes	photoreceptors
T10859	21339-21343	CL:0000604	denotes	rods
T10860	21361-21363	PR:000013773	denotes	Rb
T10861	21382-21386	CL:0000604	denotes	rods
T10862	21412-21414	PR:000013773	denotes	Rb
T10863	21418-21424	UBERON:0000966	denotes	retina
T10864	21466-21474	GO:0045202	denotes	synaptic
T10865	21484-21497	CL:0000103	denotes	bipolar cells
T10866	21526-21543	GO:0036367	denotes	photopic response
T10867	21558-21562	CL:0000573	denotes	cone
T10868	21574-21581	CL:0000103	denotes	bipolar
T10869	21612-21614	PR:000013773	denotes	Rb
T10870	21657-21659	PR:000013773	denotes	Rb
T10871	21660-21664	PR:000006852	denotes	E2f1
T10872	21669-21675	UBERON:0000966	denotes	retina
T10873	21745-21749	PR:000006852	denotes	E2f1
T10874	21764-21781	GO:0036367	denotes	photopic response
T10875	21785-21789	PR:000006852	denotes	E2f1
T10876	21793-21797	NCBITaxon:10088	denotes	mice
T10877	21865-21869	PR:000006852	denotes	E2f1
T10878	21907-21916	UBERON:0000922	denotes	embryonic
T10879	21917-21921	CL:0002672	denotes	RPCs
T10880	21931-21935	PR:000006852	denotes	E2f1
T10881	21939-21945	UBERON:0000966	denotes	retina
T10882	22002-22008	UBERON:0000966	denotes	retina
T10883	22120-22138	GO:0036367	denotes	photopic responses
T10884	22146-22148	PR:000013773	denotes	Rb
T10885	22149-22153	PR:000006852	denotes	E2f1
T10886	22158-22164	UBERON:0000966	denotes	retina
T10887	22206-22210	CL:0000573	denotes	cone
T10888	22222-22226	PR:000006852	denotes	E2f1
T10889	22230-22234	NCBITaxon:10088	denotes	mice
T10890	22278-22282	CL:0000573	denotes	cone
T10891	22308-22310	PR:000013773	denotes	Rb
T10892	22410-22424	CL:0000561	denotes	amacrine cells
T10893	22500-22504	PR:000006852	denotes	E2f1
T10894	22555-22559	PR:000006852	denotes	E2f1
T10895	22611-22614	CL:0000604	denotes	rod
T10896	22619-22623	CL:0000573	denotes	cone
T10897	22647-22649	PR:000013773	denotes	Rb
T10898	22653-22659	UBERON:0000966	denotes	retina
T13413	22912-22918	UBERON:0000966	denotes	retina
T13414	23003-23007	PR:000006852	denotes	E2f1
T13415	23016-23018	PR:000013773	denotes	Rb
T13416	23019-23023	PR:000006852	denotes	E2f1
T13417	23028-23034	UBERON:0000966	denotes	retina
T13418	23079-23089	GO:0007049	denotes	cell-cycle
T13419	23095-23104	GO:0006915	denotes	apoptosis
T13420	23166-23171	PR:000004968	denotes	Calb2
T13421	23173-23183	PR:000004968	denotes	calretinin
T13422	23210-23218	_FRAGMENT	denotes	amacrine
T13423	23232-23236	CL:0000561	denotes	cell
T13424	23223-23231	UBERON:0000045	denotes	ganglion
T13425	23223-23236	CL:0000740	denotes	ganglion cell
T13426	23232-23243	GO:0044297	denotes	cell bodies
T13427	23291-23300	GO:0042995	denotes	processes
T13428	23332-23337	PR:000004968	denotes	Calb2
T13429	23363-23367	PR:000006852	denotes	E2f1
T13430	23411-23416	PR:000004968	denotes	Calb2
T13431	23443-23445	PR:000013773	denotes	Rb
T13432	23493-23495	PR:000013773	denotes	Rb
T13433	23496-23500	PR:000006852	denotes	E2f1
T13434	23505-23511	UBERON:0000966	denotes	retina
T13435	23539-23544	PR:000004968	denotes	Calb2
T13436	23546-23557	GO:0044297	denotes	cell bodies
T13437	23565-23567	PR:000013773	denotes	Rb
T13438	23571-23574	UBERON:0001791	denotes	INL
T13439	23593-23606	CL:0000561	denotes	amacrine cell
T13440	24491-24492	UBERON:0000966	denotes	t
T13441	24495-24496	UBERON:0000966	denotes	t
T13442	24504-24506	PR:000004968	denotes	b2
T13443	24591-24605	GO:0097447	denotes	dendritic-tree
T13444	24637-24648	CHEBI:15355	denotes	cholinergic
T13445	24669-24685	CL:0000561	denotes	amacrine neurons
T13446	24808-24815	UBERON:0000966	denotes	retinal
T13447	24808-24827	GO:0060041	denotes	retinal development
T13448	24846-24849	UBERON:0001791	denotes	INL
T13449	24850-24857	GO:0045202	denotes	synapse
T13450	24949-24952	UBERON:0001792	denotes	GCL
T13451	24958-24967	GO:0042995	denotes	processes
T13452	25080-25089	GO:0042995	denotes	processes
T13453	25113-25120	PR:000014968	denotes	Slc18a3
T13454	25122-25131	GO:0031982	denotes	vesicular
T13455	25122-25158	PR:000014968	denotes	vesicular acetyl choline transporter
T13456	25132-25146	CHEBI:15355	denotes	acetyl choline
T13457	25160-25165	PR:000014968	denotes	VAChT
T13458	25223-25233	_FRAGMENT	denotes	peripheral
T13459	25259-25265	UBERON:0013682	denotes	retina
T13460	25234-25236	PR:000013773	denotes	Rb
T13461	25243-25245	PR:000013773	denotes	Rb
T13462	25246-25250	PR:000006852	denotes	E2f1
T13463	25294-25303	GO:0010467	denotes	expressed
T13464	25362-25373	GO:0044297	denotes	cell bodies
T13465	25378-25387	GO:0042995	denotes	processes
T13466	25452-25454	PR:000013773	denotes	Rb
T13467	25458-25464	UBERON:0000966	denotes	retina
T13468	25489-25493	GO:0044297	denotes	soma
T13469	25510-25519	GO:0042995	denotes	processes
T13470	25565-25569	PR:000015851	denotes	Sv2c
T13471	25573-25589	GO:0008021	denotes	synaptic vesicle
T13472	25618-25624	PR:000000940	denotes	Kcnc1b
T13473	25629-25634	PR:000000782	denotes	Kcnc2
T13474	25655-25664	GO:0010467	denotes	expressed
T13475	25672-25676	GO:0044297	denotes	soma
T13476	25681-25690	GO:0030425	denotes	dendrites
T13477	25725-25733	UBERON:0000045	denotes	ganglion
T13478	25725-25739	CL:0000740	denotes	ganglion cells
T13479	25746-25769	CHEBI:16865	denotes	gamma-aminobutyric acid
T13480	25771-25775	CHEBI:16865	denotes	GABA
T13481	25792-25808	CHEBI:25512	denotes	neurotransmitter
T13482	25834-25848	CL:0000561	denotes	amacrine cells
T13483	25876-25886	_FRAGMENT	denotes	horizontal
T13484	25904-25911	CL:0000745	denotes	neurons
T13485	25896-25911	CL:0000103	denotes	bipolar neurons
T13486	25922-25927	PR:000004967	denotes	Calb1
T13487	25929-25938	PR:000004967	denotes	calbindin
T13488	25950-25959	GO:0010467	denotes	expressed
T13489	25968-25982	CL:0000561	denotes	amacrine cells
T13490	25998-26005	GO:0042995	denotes	process
T13491	26106-26108	PR:000013773	denotes	Rb
T13492	26149-26154	PR:000017355	denotes	Chx10
T13493	26159-26168	SO:0000902	denotes	transgene
T13494	26177-26186	GO:0010467	denotes	expressed
T13495	26218-26224	UBERON:0000966	denotes	retina
T13496	26252-26262	GO:0010467	denotes	expressing
T13497	26354-26361	PR:000014968	denotes	Slc18a3
T13498	26385-26390	PR:000017355	denotes	Chx10
T13499	26395-26397	PR:000013773	denotes	Rb
T13500	26397-26401	SO:0000346	denotes	loxP
T13501	26402-26406	SO:0000346	denotes	loxP
T13502	26407-26413	UBERON:0000966	denotes	retina
T13503	26486-26488	PR:000013773	denotes	Rb
T13504	26655-26661	PR:000003199	denotes	Camk2a
T13505	26682-26690	UBERON:0000045	denotes	ganglion
T13506	26682-26696	CL:0000740	denotes	ganglion cells
T13507	26715-26723	UBERON:0000045	denotes	ganglion
T13508	26715-26729	CL:0000740	denotes	ganglion cells
T13509	26752-26754	PR:000013773	denotes	Rb
T13510	26758-26764	UBERON:0000966	denotes	retina
T13511	26766-26772	PR:000003199	denotes	Camk2a
T13512	26828-26834	PR:000003199	denotes	Camk2a
T13513	26847-26856	GO:0030425	denotes	dendrites
T13514	26889-26891	PR:000013773	denotes	Rb
T13515	26895-26901	UBERON:0000966	denotes	retina
T13516	26933-26939	PR:000003199	denotes	Camk2a
T13517	26941-26945	GO:0044297	denotes	soma
T13518	26968-26970	PR:000013773	denotes	Rb
T13519	26974-26980	UBERON:0000966	denotes	retina
T13520	27032-27034	PR:000013773	denotes	Rb
T13521	27038-27044	UBERON:0000966	denotes	retina
T13522	27118-27120	PR:000013773	denotes	Rb
T13523	27161-27168	GO:0042995	denotes	process
T13524	27203-27211	GO:0065007	denotes	regulate
T13525	27216-27226	GO:0010467	denotes	expression
T13526	27247-27252	PR:000004968	denotes	Calb2
T13527	27254-27259	PR:000004967	denotes	Calb1
T13528	27267-27274	PR:000014968	denotes	Slc18a3
T13529	27276-27280	PR:000015851	denotes	Sv2c
T13530	27282-27288	PR:000000940	denotes	Kcnc1b
T13531	27290-27295	PR:000000782	denotes	Kcnc2
T13532	27301-27305	CHEBI:16865	denotes	GABA
T13533	27326-27332	PR:000003199	denotes	Camk2a
T13534	27333-27343	GO:0010467	denotes	expression
T13535	27395-27406	GO:0044297	denotes	cell bodies
T13536	27420-27429	GO:0042995	denotes	processes
T13537	27505-27512	PR:000014968	denotes	Slc18a3
T13538	27513-27523	GO:0010467	denotes	expression
T13539	27570-27577	PR:000014968	denotes	Slc18a3
T13540	27589-27598	GO:0042995	denotes	processes
T13541	27617-27622	GO:0007567	denotes	natal
T13542	27648-27657	GO:0044297	denotes	cell body
T13543	27683-27692	GO:0042995	denotes	processes
T13544	27733-27740	PR:000014968	denotes	Slc18a3
T13545	27766-27768	PR:000013773	denotes	Rb
T13546	27772-27778	UBERON:0000966	denotes	retina
T13547	27814-27825	GO:0044297	denotes	cell bodies
T13548	27853-27855	PR:000013773	denotes	Rb
T13549	27859-27868	GO:0042995	denotes	processes
T13550	27890-27897	PR:000014968	denotes	Slc18a3
T13551	27931-27933	PR:000013773	denotes	Rb
T13552	27994-27996	PR:000013773	denotes	Rb
T16158	30785-30789	PR:000006854	denotes	E2f3
T16159	30806-30812	UBERON:0000966	denotes	retina
T16160	30820-30827	_FRAGMENT	denotes	bipolar
T16161	30841-30845	CL:0000103	denotes	cell
T16162	30832-30840	UBERON:0000045	denotes	ganglion
T16163	30832-30845	CL:0000740	denotes	ganglion cell
T16164	30841-30851	GO:0008219	denotes	cell death
T16165	30914-30918	PR:000006854	denotes	E2f3
T16166	31004-31008	PR:000006854	denotes	E2f3
T16167	31065-31067	PR:000013773	denotes	Rb
T16120	29528-29530	PR:000013773	denotes	Rb
T16121	29531-29540	GO:0065007	denotes	Regulates
T16122	29569-29573	PR:000006854	denotes	E2f3
T16123	29574-29576	PR:000013773	denotes	Rb
T16124	29627-29635	CL:0000540	denotes	neuronal
T16125	29651-29659	UBERON:0004288	denotes	skeletal
T16126	29668-29678	CL:0000136	denotes	adipocytes
T16127	29690-29692	PR:000013773	denotes	Rb
T16128	29727-29733	UBERON:0000479	denotes	tissue
T16129	29826-29828	PR:000013773	denotes	Rb
T16130	29849-29855	UBERON:0000966	denotes	retina
T16131	29943-29945	PR:000013773	denotes	Rb
T16132	29996-30006	GO:0007049	denotes	cell cycle
T16133	29996-30000	_FRAGMENT	denotes	cell
T16134	30010-30015	GO:0008219	denotes	death
T16135	30086-30094	GO:0065007	denotes	regulate
T16136	30116-30121	SO:0000704	denotes	genes
T16137	30155-30159	PR:000006853	denotes	E2f2
T16138	30163-30167	PR:000006854	denotes	E2f3
T16139	30182-30184	PR:000013773	denotes	Rb
T16140	30229-30233	PR:000006852	denotes	E2f1
T16141	30262-30269	GO:0007067	denotes	mitosis
T16142	30324-30328	PR:000006853	denotes	E2f2
T16143	30403-30407	PR:000006854	denotes	E2f3
T16144	30441-30448	GO:0007067	denotes	mitosis
T16145	30461-30466	PR:000004968	denotes	Calb2
T16146	30468-30475	PR:000014968	denotes	Slc18a3
T16147	30483-30487	CHEBI:16865	denotes	GABA
T16148	30489-30495	PR:000000940	denotes	Kcnc1b
T16149	30497-30502	PR:000000782	denotes	Kcnc2
T16150	30508-30512	PR:000015851	denotes	Sv2c
T16151	30572-30574	PR:000013773	denotes	Rb
T16152	30575-30579	PR:000006854	denotes	E2f3
T16153	30636-30642	UBERON:0000966	denotes	retina
T16154	30682-30690	GO:0045202	denotes	synaptic
T16155	30726-30730	PR:000006852	denotes	E2f1
T16156	30777-30779	PR:000013773	denotes	Rb
T16157	30780-30784	PR:000006852	denotes	E2f1
T16168	31082-31086	PR:000006854	denotes	E2f3
T16169	31118-31124	PR:000003199	denotes	Camk2a
T16170	31183-31189	PR:000003199	denotes	Camk2a
T16171	31197-31206	GO:0010467	denotes	expressed
T16172	31216-31223	PR:000014968	denotes	Slc18a3
T16173	31259-31261	PR:000013773	denotes	Rb
T16174	31265-31271	UBERON:0000966	denotes	retina
T16175	31305-31307	PR:000013773	denotes	Rb
T16176	31308-31312	PR:000006852	denotes	E2f1
T16177	31317-31323	UBERON:0000966	denotes	retina
T16178	31348-31350	PR:000013773	denotes	Rb
T16179	31351-31355	PR:000006854	denotes	E2f3
T16180	31360-31366	UBERON:0000966	denotes	retina
T16181	31426-31434	UBERON:0000045	denotes	ganglion
T16182	31426-31440	CL:0000740	denotes	ganglion cells
T16183	31473-31479	PR:000003199	denotes	Camk2a
T16184	31502-31511	GO:0006915	denotes	apoptosis
T16185	31609-31613	PR:000009116	denotes	Isl1
T16186	31615-31621	PR:000009116	denotes	Islet1
T16187	31639-31648	GO:0010467	denotes	expressed
T16188	31666-31674	UBERON:0000045	denotes	ganglion
T16189	31666-31680	CL:0000740	denotes	ganglion cells
T16190	31687-31691	PR:000009116	denotes	Isl1
T16191	31706-31709	UBERON:0001791	denotes	INL
T16192	31767-31771	PR:000009116	denotes	Isl1
T16193	31800-31803	UBERON:0001791	denotes	INL
T16194	31820-31827	PR:000014968	denotes	Slc18a3
T16195	31846-31850	PR:000009116	denotes	Isl1
T16196	31901-31905	PR:000009116	denotes	Isl1
T16197	31914-31921	PR:000014968	denotes	Slc18a3
T16198	31926-31933	GO:0005634	denotes	nuclear
T16199	31964-31968	PR:000009116	denotes	Isl1
T16200	31970-31975	PR:000010425	denotes	Mki67
T16201	31995-32004	GO:0010467	denotes	expressed
T16202	32018-32025	PR:000014968	denotes	Slc18a3
T16203	32108-32114	UBERON:0000966	denotes	retina
T16204	32172-32178	UBERON:0000966	denotes	retina
T16205	32192-32194	PR:000013773	denotes	Rb
T16206	32207-32217	GO:0007049	denotes	cell cycle
T16207	32282-32286	PR:000009116	denotes	Isl1
T16208	32307-32319	CL:0000031	denotes	neuroblastic
T16209	32353-32356	UBERON:0001791	denotes	INL
T16210	32385-32389	PR:000009116	denotes	Isl1
T16211	32391-32396	PR:000010425	denotes	Mki67
T16212	32425-32427	PR:000013773	denotes	Rb
T16213	32485-32489	PR:000009116	denotes	Isl1
T16214	32542-32544	PR:000013773	denotes	Rb
T16215	32548-32554	UBERON:0000966	denotes	retina
T16216	32594-32603	GO:0010467	denotes	expressed
T16217	32670-32672	PR:000013773	denotes	Rb
T16218	32673-32677	PR:000006852	denotes	E2f1
T16219	32682-32688	UBERON:0000966	denotes	retina
T16220	32745-32747	PR:000013773	denotes	Rb
T16221	32748-32752	PR:000006854	denotes	E2f3
T16222	32757-32763	UBERON:0000966	denotes	retina
T16223	32862-32867	PR:000004968	denotes	Calb2
T16224	32904-32918	CL:0000561	denotes	amacrine cells
T16225	32946-32948	PR:000013773	denotes	Rb
T16226	32958-32962	PR:000006852	denotes	E2f1
T16227	33042-33046	PR:000006854	denotes	E2f3
T18188	34291-34295	PR:000006854	denotes	E2f3
T18189	34295-34299	SO:0000346	denotes	loxP
T18190	34300-34304	SO:0000346	denotes	loxP
T18191	34305-34309	NCBITaxon:10088	denotes	mice
T18192	34353-34357	PR:000006854	denotes	E2f3
T18193	34378-34385	PR:000014968	denotes	Slc18a3
T18194	34409-34413	PR:000006854	denotes	E2f3
T18195	34437-34441	GO:0044297	denotes	soma
T18196	34446-34455	GO:0030425	denotes	dendrites
T18169	33591-33601	GO:0010467	denotes	expression
T18170	33621-33625	PR:000006854	denotes	E2f3
T18171	33642-33646	CL:0002672	denotes	RPCs
T18172	33690-33703	GO:0008283	denotes	proliferation
T18173	33765-33769	PR:000006854	denotes	E2f3
T18174	33773-33790	UBERON:0013682	denotes	peripheral retina
T18175	33811-33817	UBERON:0000966	denotes	retina
T18176	33837-33840	CL:0002672	denotes	RPC
T18177	33876-33880	PR:000006854	denotes	E2f3
T18178	33968-33975	GO:0007067	denotes	mitotic
T18179	33995-34001	UBERON:0000966	denotes	retina
T18180	34002-34011	GO:0010467	denotes	expressed
T18181	34012-34016	PR:000006854	denotes	E2f3
T18182	34038-34042	PR:000006854	denotes	E2f3
T18183	34150-34157	PR:000014968	denotes	Slc18a3
T18184	34187-34198	GO:0005737	denotes	cytoplasmic
T18185	34199-34203	PR:000006854	denotes	E2f3
T18186	34256-34260	PR:000006854	denotes	E2f3
T18187	34264-34281	UBERON:0013682	denotes	peripheral retina
T18197	34469-34471	PR:000013773	denotes	Rb
T18198	34511-34517	UBERON:0000966	denotes	retina
T18199	34568-34572	PR:000006854	denotes	E2f3
T18200	34625-34633	UBERON:0000045	denotes	ganglion
T18201	34625-34639	CL:0000740	denotes	ganglion cells
T18202	34644-34656	CL:0011107	denotes	Müller cells
T18203	34675-34677	PR:000013773	denotes	Rb
T18204	34694-34703	GO:0042995	denotes	processes
T18205	34741-34758	UBERON:0013682	denotes	peripheral retina
T18206	34767-34769	PR:000013773	denotes	Rb
T18207	34769-34773	SO:0000346	denotes	loxP
T18208	34774-34778	SO:0000346	denotes	loxP
T18209	34779-34783	NCBITaxon:10088	denotes	mice
T18210	34821-34823	PR:000013773	denotes	Rb
T18211	34828-34832	PR:000006854	denotes	E2f3
T18212	34861-34865	PR:000006854	denotes	E2f3
T18213	34933-34942	GO:0010467	denotes	expressed
T18214	34952-34959	UBERON:0000966	denotes	retinal
T18215	34960-34967	CL:0000540	denotes	neurons
T18232	36169-36180	CHEBI:15355	denotes	cholinergic
T18233	36169-36188	CL:0000108	denotes	cholinergic neurons
T18234	36208-36218	_FRAGMENT	denotes	regions of
T18235	36223-36228	UBERON:0002616	denotes	brain
T18236	36233-36244	UBERON:0001948	denotes	spinal cord
T18237	36308-36319	CHEBI:15355	denotes	cholinergic
T18238	36308-36319	_FRAGMENT	denotes	cholinergic
T18239	36326-36333	CL:0000108	denotes	neurons
T18240	36320-36322	PR:000013773	denotes	Rb
T18241	36352-36361	UBERON:0001890	denotes	forebrain
T18242	36373-36375	PR:000013773	denotes	Rb
T18243	36379-36386	CL:0000540	denotes	neurons
T18244	36463-36467	PR:000006854	denotes	E2f3
T18245	36541-36543	PR:000013773	denotes	Rb
T18246	36587-36591	PR:000006854	denotes	E2f3
T20025	36630-36634	PR:000006854	denotes	E2f3
T20026	36635-36643	SO:0001060	denotes	Isoforms
T20027	36660-36664	PR:000006854	denotes	E2f3
T20028	36669-36671	PR:000013773	denotes	Rb
T20029	36698-36705	GO:0005634	denotes	nuclear
T20030	36710-36721	GO:0005737	denotes	cytoplasmic
T20031	36746-36754	GO:0042571	denotes	antibody
T20032	36851-36859	SO:0001060	denotes	isoforms
T20033	36907-36911	PR:000006854	denotes	E2f3
T20034	36912-36920	SO:0001060	denotes	isoforms
T20035	36995-36999	PR:000006854	denotes	E2f3
T20036	37023-37031	SO:0001060	denotes	isoforms
T20037	37048-37054	UBERON:0000966	denotes	retina
T20038	37068-37075	GO:0005634	denotes	nuclear
T20039	37080-37091	GO:0005737	denotes	cytoplasmic
T20040	37179-37183	PR:000006854	denotes	E2f3
T20041	37184-37192	GO:0042571	denotes	antibody
T20042	37245-37250	PR:000028775	denotes	E2f3a
T20043	37342-37349	UBERON:0000966	denotes	retinal
T20044	37362-37367	PR:000028775	denotes	E2f3a
T20045	37388-37392	NCBITaxon:10088	denotes	mice
T20046	37403-37407	PR:000006854	denotes	E2f3
T20047	37408-37412	SO:0000147	denotes	exon
T20048	37425-37432	GO:0010467	denotes	express
T20049	37632-37637	PR:000028775	denotes	E2f3a
T20050	37641-37645	NCBITaxon:10088	denotes	mice
T20051	37694-37698	PR:000006854	denotes	E2f3
T20052	37699-37709	GO:0010467	denotes	expressing
T20053	37726-37733	UBERON:0000966	denotes	retinal
T20054	37778-37783	PR:000028775	denotes	E2f3a
T20055	37900-37905	PR:000028775	denotes	E2f3a
T20056	37926-37933	GO:0005634	denotes	nuclear
T20091	41141-41147	UBERON:0000966	denotes	retina
T20092	41154-41158	PR:000006852	denotes	E2f1
T20093	41185-41192	GO:0005634	denotes	nuclear
T20094	41197-41208	GO:0005737	denotes	cytoplasmic
T20095	41236-41241	PR:000028775	denotes	E2f3a
T20096	41263-41270	GO:0005634	denotes	nuclear
T20097	41310-41322	GO:0046983	denotes	dimerization
T20098	41332-41337	PR:000016269	denotes	Tfdp1
T20099	41353-41360	GO:0005634	denotes	nuclear
T20100	41353-41380	SO:0001528	denotes	nuclear localization signal
T20101	41401-41412	GO:0005737	denotes	cytoplasmic
T20102	41456-41462	PR:000005274	denotes	Cdkn1a
T20103	41467-41473	PR:000003090	denotes	Cdkn1b
T20104	41543-41553	GO:0007049	denotes	cell cycle
T20105	41649-41656	GO:0005634	denotes	nuclear
T21372	41680-41682	PR:000013773	denotes	Rb
T21373	41683-41692	GO:0065007	denotes	Regulates
T21374	41721-41726	PR:000028775	denotes	E2f3a
T21375	41741-41745	PR:000006854	denotes	E2f3
T21376	41746-41753	SO:0001060	denotes	isoform
T21377	41782-41784	PR:000013773	denotes	Rb
T21378	41821-41826	PR:000028775	denotes	E2f3a
T21379	41830-41834	NCBITaxon:10088	denotes	mice
T21380	41922-41927	PR:000028775	denotes	E2f3a
T21381	41942-41949	SO:0001023	denotes	alleles
T21382	42017-42022	PR:000028775	denotes	E2f3a
T21383	42066-42072	UBERON:0000966	denotes	retina
T21384	42102-42107	PR:000028775	denotes	E2f3a
T21385	42119-42124	PR:000028775	denotes	E2f3a
T21386	42128-42134	UBERON:0000966	denotes	retina
T21387	42148-42153	PR:000028775	denotes	E2f3a
T21388	42176-42181	PR:000028775	denotes	E2f3a
T21389	42185-42192	UBERON:0000966	denotes	retinal
T21390	42253-42260	SO:0000673	denotes	message
T21391	42253-42260	CHEBI:33695	denotes	message
T21392	42281-42283	PR:000013773	denotes	Rb
T21393	42291-42293	PR:000013773	denotes	Rb
T21394	42294-42299	PR:000028775	denotes	E2f3a
T21395	42304-42310	UBERON:0000966	denotes	retina
T21396	42359-42364	PR:000028775	denotes	E2f3a
T21397	42493-42495	PR:000013773	denotes	Rb
T21398	42500-42502	PR:000013773	denotes	Rb
T21399	42503-42507	PR:000006854	denotes	E2f3
T21400	42517-42519	PR:000013773	denotes	Rb
T21401	42520-42525	PR:000028775	denotes	E2f3a
T21402	42530-42536	UBERON:0000966	denotes	retina
T21403	42559-42569	GO:0065007	denotes	regulatory
T21404	42596-42601	PR:000028775	denotes	E2f3a
T21405	42614-42624	GO:0007049	denotes	cell cycle
T21406	42678-42688	GO:0007049	denotes	cell cycle
T21407	42783-42785	PR:000013773	denotes	Rb
T21408	42789-42798	GO:0044838	denotes	quiescent
T21409	42869-42871	PR:000013773	denotes	Rb
T21410	42904-42909	PR:000028775	denotes	E2f3a
T21411	42934-42936	PR:000013773	denotes	Rb
T21412	42996-43014	GO:0051726	denotes	cell cycle control
T21413	43016-43018	PR:000013773	denotes	Rb
T21414	43019-43029	GO:0065007	denotes	regulation
T21415	43033-43038	PR:000028775	denotes	E2f3a
T21416	43068-43076	CL:0000540	denotes	neuronal
T22813	44262-44266	PR:000006852	denotes	E2f1
T22814	44276-44284	GO:0065007	denotes	regulate
T22815	44353-44360	UBERON:0000966	denotes	retinal
T22816	44353-44365	CL:0009004	denotes	retinal cell
T22817	44361-44376	GO:0048469	denotes	cell maturation
T22818	44447-44456	GO:0065007	denotes	regulated
T22819	44470-44475	GO:0016265	denotes	death
T22820	44515-44522	UBERON:0000966	denotes	retinal
T22769	43107-43109	PR:000013773	denotes	Rb
T22770	43110-43118	GO:0065007	denotes	Controls
T22771	43119-43126	UBERON:0000966	denotes	Retinal
T22772	43119-43131	CL:0009004	denotes	Retinal Cell
T22773	43127-43140	GO:0051301	denotes	Cell Division
T22774	43127-43131	_FRAGMENT	denotes	Cell
T22775	43145-43150	GO:0008219	denotes	Death
T22776	43159-43163	PR:000006852	denotes	E2f1
T22777	43200-43202	PR:000013773	denotes	Rb
T22778	43228-43236	CL:0000540	denotes	neuronal
T22779	43237-43247	GO:0007049	denotes	cell cycle
T22780	43305-43310	GO:0016265	denotes	death
T22781	43368-43377	UBERON:0001987	denotes	placental
T22782	43449-43451	PR:000013773	denotes	Rb
T22783	43474-43484	GO:0007049	denotes	cell cycle
T22784	43501-43508	CL:0000540	denotes	neurons
T22785	43554-43561	CL:0000540	denotes	neurons
T22786	43583-43589	UBERON:0000966	denotes	retina
T22787	43626-43628	PR:000013773	denotes	Rb
T22788	43634-43643	GO:0065007	denotes	regulates
T22789	43728-43733	GO:0016265	denotes	death
T22790	43770-43772	PR:000013773	denotes	Rb
T22791	43777-43785	GO:0065007	denotes	regulate
T22792	43786-43794	CL:0000540	denotes	neuronal
T22793	43786-43805	GO:0042551	denotes	neuronal maturation
T22794	43846-43850	PR:000006852	denotes	E2f1
T22795	43893-43898	GO:0016265	denotes	death
T22796	43906-43908	PR:000013773	denotes	Rb
T22797	43912-43918	UBERON:0000966	denotes	retina
T22798	43939-43941	PR:000013773	denotes	Rb
T22799	43942-43946	PR:000006852	denotes	E2f1
T22800	43951-43958	CL:0000540	denotes	neurons
T22801	44016-44019	CL:0000604	denotes	rod
T22802	44025-44029	CL:0000573	denotes	cone
T22803	44088-44102	CL:0000210	denotes	photoreceptors
T22804	44106-44113	_FRAGMENT	denotes	bipolar
T22805	44127-44132	CL:0000103	denotes	cells
T22806	44118-44132	CL:0000561	denotes	amacrine cells
T22807	44147-44152	GO:0016265	denotes	death
T22808	44153-44158	SO:0000704	denotes	genes
T22809	44175-44177	PR:000013773	denotes	Rb
T22810	44201-44205	PR:000006852	denotes	E2f1
T22811	44215-44219	PR:000006853	denotes	E2f2
T22812	44223-44227	PR:000006854	denotes	E2f3
T22821	44515-44528	CL:0009004	denotes	retinal cells
T22822	44540-44554	CL:0000210	denotes	photoreceptors
T22823	44638-44640	PR:000013773	denotes	Rb
T22824	44666-44670	PR:000006852	denotes	E2f1
T22825	44722-44727	GO:0016265	denotes	death
T22826	44769-44771	PR:000013773	denotes	Rb
T22827	44804-44814	NCBITaxon:11632	denotes	retrovirus
T22828	44815-44821	SO:0000440	denotes	vector
T22829	44911-44915	PR:000006852	denotes	E2f1
T22830	44920-44930	GO:0010467	denotes	expression
T22831	44942-44956	CL:0000210	denotes	photoreceptors
T22832	44985-44994	GO:0006915	denotes	apoptosis
T22833	45049-45053	PR:000006852	denotes	E2f1
T22834	45141-45150	GO:0006915	denotes	apoptosis
T22835	45154-45156	PR:000013773	denotes	Rb
T22836	45183-45192	GO:0065007	denotes	regulated
T22837	45193-45197	PR:000006852	denotes	E2f1
T22838	45214-45220	UBERON:0000966	denotes	retina
T22839	45265-45267	PR:000013773	denotes	Rb
T22840	45280-45290	GO:0010467	denotes	expression
T22841	45313-45326	GO:0051301	denotes	cell division
T22842	45340-45349	GO:0006915	denotes	apoptosis
T22843	45371-45375	PR:000006852	denotes	E2f1
T22844	45479-45482	PR:000013773	denotes	RB1
T22845	45487-45493	NCBITaxon:9606	denotes	humans
T22846	45534-45536	PR:000013773	denotes	Rb
T22847	45540-45543	CL:0000604	denotes	rod
T22848	45544-45551	CL:0000103	denotes	bipolar
T22849	45599-45603	CL:0000573	denotes	cone
T22850	45604-45611	CL:0000103	denotes	bipolar
T22851	45629-45633	PR:000006852	denotes	E2f1
T22852	45687-45689	PR:000013773	denotes	Rb
T22853	45690-45694	PR:000006852	denotes	E2f1
T22854	45699-45705	UBERON:0000966	denotes	retina
T22855	45722-45726	PR:000006852	denotes	E2f1
T22856	45738-45744	UBERON:0000966	denotes	retina
T22857	45787-45789	PR:000013773	denotes	Rb
T22858	45797-45817	GO:0046549	denotes	development of cones
T22859	45797-45811	_FRAGMENT	denotes	development of
T22860	45827-45832	GO:0048468	denotes	cells
T22861	45843-45848	GO:0048468	denotes	cells
T22862	45812-45817	CL:0000573	denotes	cones
T22863	45819-45832	CL:0000103	denotes	bipolar cells
T22864	45876-45884	GO:0036367	denotes	photopic
T22865	45956-45958	PR:000013773	denotes	Rb
T22866	45959-45963	PR:000006852	denotes	E2f1
T22867	45968-45974	UBERON:0000966	denotes	retina
T24468	48110-48114	PR:000006854	denotes	E2f3
T24469	48127-48136	GO:0065007	denotes	regulated
T24470	48137-48147	GO:0010467	denotes	expression
T24471	48151-48161	GO:0007049	denotes	cell cycle
T24472	48176-48181	SO:0000704	denotes	genes
T24473	48189-48191	PR:000013773	denotes	Rb
T24474	48195-48201	UBERON:0000966	denotes	retina
T24475	48203-48207	PR:000006854	denotes	E2f3
T24444	46562-46570	CL:0000540	denotes	neuronal
T24445	46586-46594	UBERON:0004288	denotes	skeletal
T24446	46603-46613	CL:0000136	denotes	adipocytes
T24447	46650-46656	UBERON:0000479	denotes	tissue
T24448	46740-46742	PR:000013773	denotes	Rb
T24449	46791-46796	PR:000010875	denotes	Myod1
T24450	46939-46941	PR:000013773	denotes	Rb
T24451	46979-46983	PR:000006854	denotes	E2f3
T24452	47006-47008	PR:000013773	denotes	Rb
T24453	47015-47690	GO:0007067	denotes	tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati
T24454	47724-47728	PR:000006854	denotes	E2f3
T24455	47760-47771	GO:0065007	denotes	controlling
T24456	47784-47789	GO:0016265	denotes	death
T24457	47791-47795	PR:000006854	denotes	E2f3
T24458	47813-47815	PR:000013773	denotes	Rb
T24459	47861-47874	GO:0008283	denotes	proliferation
T24460	47878-47883	GO:0016265	denotes	death
T24461	47893-47897	PR:000006852	denotes	E2f1
T24462	47925-47938	GO:0008283	denotes	proliferation
T24463	47943-47948	GO:0016265	denotes	death
T24464	48021-48025	PR:000006852	denotes	E2f1
T24465	48034-48038	PR:000006854	denotes	E2f3
T24466	48057-48059	PR:000013773	denotes	Rb
T24467	48096-48100	PR:000006852	denotes	E2f1
T24476	48211-48220	GO:0010467	denotes	expressed
T24477	48236-48239	UBERON:0001017	denotes	CNS
T24478	48236-48247	CL:0000117	denotes	CNS neurons
T24479	48280-48290	GO:0007049	denotes	cell-cycle
T24480	48314-48316	PR:000013773	denotes	Rb
T24481	48320-48329	UBERON:0001890	denotes	forebrain
T24482	48320-48337	CL:0012001	denotes	forebrain neurons
T24483	48350-48354	PR:000006854	denotes	E2f3
T24484	48420-48422	PR:000013773	denotes	Rb
T24485	48448-48456	CL:0000540	denotes	neuronal
T24486	48520-48522	PR:000013773	denotes	Rb
T24487	48549-48553	PR:000006854	denotes	E2f3
T24488	48554-48561	SO:0001060	denotes	isoform
T24489	48640-48642	PR:000013773	denotes	Rb
T24490	48687-48696	GO:0044838	denotes	quiescent
T24491	48805-48812	SO:0001060	denotes	isoform
T24492	48862-48864	PR:000013773	denotes	Rb
T24493	48865-48874	GO:0065007	denotes	regulates
T24494	48903-48908	PR:000028775	denotes	E2f3a
T24495	49081-49085	NCBITaxon:10088	denotes	mice
T24496	49121-49123	PR:000013773	denotes	Rb
T24497	49135-49144	GO:0065007	denotes	regulates
T24498	49188-49192	PR:000006854	denotes	E2f3
T24499	49193-49200	SO:0001060	denotes	isoform
T25603	49212-49217	PR:000028775	denotes	E2f3a
T25604	49273-49281	SO:0001060	denotes	isoforms
T25605	49330-49335	PR:000028775	denotes	E2f3a
T25606	49395-49398	SO:0001528	denotes	NLS
T25607	49446-49448	PR:000013773	denotes	Rb
T25608	49457-49464	SO:0000417	denotes	domains
T25609	49537-49544	UBERON:0000966	denotes	retinal
T25610	49537-49550	CL:0009004	denotes	retinal cells
T25611	49552-49557	PR:000028775	denotes	E2f3a
T25612	49566-49573	GO:0005634	denotes	nuclear
T25613	49578-49589	GO:0005737	denotes	cytoplasmic
T25614	49611-49618	GO:0005634	denotes	nuclear
T25615	49665-49670	PR:000028775	denotes	E2f3a
T25616	49743-49747	PR:000006852	denotes	E2f1
T25617	49749-49753	PR:000006853	denotes	E2f2
T25618	49759-49764	PR:000028775	denotes	E2f3a
T25619	49771-49776	PR:000005115	denotes	Ccna2
T25620	49852-49859	GO:0051320	denotes	S-phase
T25621	49907-49913	SO:0000417	denotes	domain
T25622	49928-49937	GO:0065007	denotes	regulated
T25623	49941-49946	PR:000005115	denotes	Ccna2
T25624	49960-49966	SO:0000417	denotes	domain
T25625	50032-50034	PR:000013773	denotes	Rb
T25626	50141-50143	PR:000013773	denotes	Rb
T25627	50148-50153	PR:000016269	denotes	Tfdp1
T25628	50167-50178	GO:0005737	denotes	cytoplasmic
T25629	50182-50189	UBERON:0000966	denotes	retinal
T25630	50182-50195	CL:0009004	denotes	retinal cells
T25631	50234-50236	PR:000013773	denotes	Rb
T25632	50241-50245	PR:000006854	denotes	E2f3
T25633	50264-50273	GO:0042995	denotes	processes
T25634	50279-50286	GO:0005634	denotes	nuclear
T25635	50387-50391	PR:000006856	denotes	E2f5
T25636	50410-50417	GO:0005634	denotes	nucleus
T25637	50421-50430	GO:0005737	denotes	cytoplasm
T25638	50438-50442	PR:000006855	denotes	E2f4
T25639	50515-50520	PR:000028775	denotes	E2f3a
T25640	50538-50544	UBERON:0000966	denotes	retina
T25641	50603-50605	PR:000013773	denotes	Rb
T25642	50635-50640	PR:000028775	denotes	E2f3a
T25643	50718-50723	PR:000028775	denotes	E2f3a
T26539	51258-51264	UBERON:0000966	denotes	retina
T26540	51326-51328	PR:000013773	denotes	Rb
T26541	51364-51371	GO:0010467	denotes	express
T26542	51416-51421	UBERON:0000955	denotes	brain
T26530	50763-50765	PR:000013773	denotes	Rb
T26531	50850-50860	GO:0007049	denotes	cell cycle
T26532	50868-50875	CL:0000540	denotes	neurons
T26533	50877-50880	_FRAGMENT	denotes	gut
T26534	50890-50899	UBERON:0003929	denotes	epithelia
T26535	50885-50899	UBERON:0019204	denotes	skin epithelia
T26536	50913-50924	CL:0011004	denotes	lens fibres
T26537	50956-50966	GO:0010467	denotes	expression
T26538	50994-50996	PR:000013773	denotes	Rb
T26543	51423-51425	PR:000013773	denotes	Rb
T26544	51429-51436	CL:0000540	denotes	neurons
T26545	51459-51475	UBERON:0003053	denotes	ventricular zone
T26546	51490-51495	PR:000016819	denotes	Tubb3
T26547	51497-51509	PR:000016819	denotes	βIII-tubulin
T26548	51540-51544	CHEBI:472552	denotes	BrdU
T26549	51558-51571	UBERON:0003929	denotes	gut epithelia
T26550	51588-51599	CL:0000584	denotes	enterocytes
T26551	51634-51644	GO:0010467	denotes	expression
T26552	51648-51657	CHEBI:28790	denotes	serotonin
T26553	51687-51691	CHEBI:472552	denotes	BrdU
T26554	51774-51781	PR:000014968	denotes	Slc18a3
T26555	52058-52069	_FRAGMENT	denotes	division of
T26556	52097-52102	GO:0051301	denotes	cells
T27179	52735-52747	GO:0022008	denotes	neurogenesis
T27180	52817-52822	PR:000028775	denotes	E2f3a
T27181	52839-52844	SO:0000704	denotes	genes
T27182	52848-52859	GO:0005737	denotes	cytoplasmic
T27183	52889-52896	CL:0000540	denotes	neurons
T27184	52939-52945	UBERON:0000966	denotes	retina
T27185	52964-52980	CL:0000561	denotes	amacrine neurons
T27744	53008-53010	PR:000013773	denotes	Rb
T27745	53049-53051	PR:000013773	denotes	Rb
T27747	53227-53229	PR:000013773	denotes	Rb
T27748	53308-53310	PR:000013773	denotes	Rb
T27749	53421-53429	CHEBI:75958	denotes	solution
T27750	53510-53519	GO:0000785	denotes	chromatin
T27751	53577-53579	PR:000013773	denotes	Rb
T27752	53605-53611	UBERON:0000479	denotes	tissue
T27753	53724-53726	PR:000013773	denotes	Rb
T27754	53829-53831	PR:000013773	denotes	Rb
T27755	53985-53987	PR:000013773	denotes	Rb
T27756	53991-53998	UBERON:0000479	denotes	tissues
T28308	54096-54101	NCBITaxon:10088	denotes	Mouse
T28309	54126-54130	NCBITaxon:10088	denotes	Mice
T28310	54202-54206	NCBITaxon:10088	denotes	mice
T28311	54219-54224	PR:000017355	denotes	Chx10
T28312	54229-54233	NCBITaxon:10088	denotes	mice
T28313	54246-54248	PR:000013773	denotes	Rb
T28314	54248-54252	SO:0000346	denotes	loxP
T28315	54253-54257	SO:0000346	denotes	loxP
T28316	54258-54262	NCBITaxon:10088	denotes	mice
T28317	54275-54279	PR:000006852	denotes	E2f1
T28318	54283-54287	NCBITaxon:10088	denotes	mice
T28319	54289-54293	PR:000006853	denotes	E2f2
T28320	54297-54301	NCBITaxon:10088	denotes	mice
T28321	54303-54307	PR:000006854	denotes	E2f3
T28322	54307-54311	SO:0000346	denotes	loxP
T28323	54312-54316	SO:0000346	denotes	loxP
T28324	54317-54321	NCBITaxon:10088	denotes	mice
T28325	54327-54332	PR:000028775	denotes	E2f3a
T28326	54336-54340	NCBITaxon:10088	denotes	mice
T28327	54438-54443	PR:000028775	denotes	E2f3a
T28328	54447-54451	NCBITaxon:10088	denotes	mice
T28329	54481-54485	NCBITaxon:10088	denotes	Mice
T28330	54701-54708	SO:0000112	denotes	primers
T28331	54729-54734	PR:000028775	denotes	E2f3a
T28332	54738-54742	NCBITaxon:10088	denotes	mice
T28333	54748-54753	PR:000028775	denotes	E2f3a
T28334	54787-54792	PR:000028775	denotes	E2f3a
T28335	54831-54836	PR:000028775	denotes	E2f3a
T29503	54920-54928	UBERON:0010230	denotes	Eyeballs
T29504	55151-55158	GO:0051320	denotes	S-phase
T29505	55169-55173	CHEBI:472552	denotes	BrdU
T29506	55218-55230	UBERON:0001179	denotes	peritoneally
T29507	55255-55259	CHEBI:472552	denotes	BrdU
T29508	55289-55295	CHEBI:15956	denotes	biotin
T29509	55289-55306	MOP:0000093	denotes	biotin-conjugated
T29510	55307-55312	NCBITaxon:9940	denotes	sheep
T29511	55324-55332	GO:0042571	denotes	antibody
T29512	55417-55427	GO:0042571	denotes	antibodies
T29513	55459-55463	PR:000006854	denotes	E2f3
T29514	55465-55470	PR:000010425	denotes	Mki67
T29515	55476-55478	PR:000013773	denotes	Rb
T29516	55489-55496	CHEBI:59132	denotes	antigen
T29517	55544-55555	CHEBI:30769	denotes	citric acid
T29518	55556-55564	CHEBI:75958	denotes	solution
T29519	55729-55736	CHEBI:60004	denotes	mixture
T29520	55737-55745	CHEBI:75958	denotes	solution
T29521	55816-55822	CHEBI:15956	denotes	biotin
T29522	55842-55847	CHEBI:35696	denotes	CoCl2
T29523	55929-55934	CHEBI:15377	denotes	water
T29524	56002-56011	CHEBI:52661	denotes	Alexa 488
T29525	56016-56025	CHEBI:51766	denotes	Alexa 568
T29526	56134-56144	GO:0042571	denotes	antibodies
T29527	56185-56191	NCBITaxon:9793	denotes	donkey
T29528	56197-56202	NCBITaxon:10088	denotes	mouse
T29529	56203-56212	CHEBI:52661	denotes	Alexa 488
T29530	56216-56225	CHEBI:51766	denotes	Alexa 568
T29531	56227-56233	NCBITaxon:9793	denotes	donkey
T29532	56239-56245	NCBITaxon:9986	denotes	rabbit
T29533	56246-56255	CHEBI:52661	denotes	Alexa 488
T29534	56259-56268	CHEBI:51766	denotes	Alexa 568
T29535	56270-56276	NCBITaxon:9793	denotes	donkey
T29536	56282-56286	NCBITaxon:9925	denotes	goat
T29537	56287-56296	CHEBI:52661	denotes	Alexa 488
T29538	56300-56309	CHEBI:51766	denotes	Alexa 568
T29539	56328-56337	CHEBI:52661	denotes	Alexa 488
T29540	56341-56350	CHEBI:51766	denotes	Alexa 568
T29541	56380-56386	GO:0005634	denotes	Nuclei
T29542	56413-56440	CHEBI:51231	denotes	4,6-diamidino-2-phenyindole
T29543	56442-56446	CHEBI:51231	denotes	DAPI
T29544	56766-56772	UBERON:0000966	denotes	retina
T29545	56819-56830	UBERON:0004086	denotes	ventricular
T29546	56843-56849	UBERON:0000966	denotes	retina
T29547	56895-56902	UBERON:0001797	denotes	vitreal
T29548	56944-56953	GO:0010467	denotes	expressed
T29549	56994-57000	UBERON:0000966	denotes	retina
T29550	57058-57065	GO:0010467	denotes	express
T29551	57290-57297	GO:0051320	denotes	S-phase
T29552	57299-57306	GO:0000279	denotes	M-phase
T29553	57312-57327	CL:0000445	denotes	apoptotic cells
T29554	57383-57388	UBERON:0000970	denotes	optic
T29555	57508-57513	UBERON:0000970	denotes	optic
T29556	57553-57556	UBERON:0000970	denotes	eye
T29557	57567-57571	UBERON:0000970	denotes	eyes
T30706	57626-57647	GO:0001171	denotes	reverse transcription
T30707	57696-57713	UBERON:0013682	denotes	peripheral retina
T30708	57727-57734	CHEBI:33893	denotes	reagent
T30709	58026-58033	SO:0000112	denotes	primers
T30710	58242-58252	CHEBI:51461	denotes	SYBR Green
T30711	58264-58267	CHEBI:60004	denotes	Mix
T30712	58415-58425	CHEBI:51461	denotes	SYBR Green
T30713	58437-58440	CHEBI:60004	denotes	Mix
T30714	58457-58464	_FRAGMENT	denotes	forward
T30715	58477-58483	SO:0000121	denotes	primer
T30716	58469-58483	SO:0000132	denotes	reverse primer
T30717	58514-58517	CHEBI:15377	denotes	H2O
T30718	58530-58541	CHEBI:77182	denotes	Food Colour
T30719	58631-58634	CHEBI:15377	denotes	H2O
T30720	58649-58660	CHEBI:77182	denotes	Food Colour
T30721	58728-58737	GO:0097617	denotes	annealing
T30722	58998-59004	SO:0000112	denotes	primer
T30723	59047-59054	SO:0001026	denotes	genomic
T30724	59148-59153	PR:000008735	denotes	Hprt1
T31521	59183-59188	NCBITaxon:10088	denotes	Mouse
T31522	59189-59196	UBERON:0000966	denotes	retinas
T31523	59301-59309	CHEBI:75958	denotes	solution
T31524	59311-59318	GO:0005634	denotes	Nuclear
T31525	59323-59334	GO:0005737	denotes	cytoplasmic
T31526	59376-59383	GO:0005634	denotes	Nuclear
T31527	59388-59399	GO:0005737	denotes	Cytoplasmic
T31528	59512-59515	CHEBI:8984	denotes	SDS
T31529	59540-59554	CHEBI:53325	denotes	nitrocellulose
T31530	59600-59604	UBERON:0001913	denotes	milk
T31531	59646-59654	GO:0042571	denotes	antibody
T31532	59726-59733	CHEBI:34683	denotes	Na2HPO4
T31533	59742-59749	CHEBI:37585	denotes	NaH2PO4
T31534	59757-59761	CHEBI:26710	denotes	NaCl
T31535	59768-59776	CHEBI:53424	denotes	Tween-20
T31536	59852-59863	NCBITaxon:3704	denotes	horseradish
T31537	59875-59885	MOP:0000779	denotes	conjugated
T31538	59886-59894	GO:0042571	denotes	antibody
T31539	60161-60171	GO:0042571	denotes	antibodies
T31540	60183-60188	PR:000006852	denotes	E2f-1
T31541	60199-60204	PR:000006854	denotes	E2f-3
T31542	60215-60221	PR:000005274	denotes	Cdkn1a
T31543	60223-60226	PR:000005274	denotes	p21
T31544	60237-60243	PR:000003090	denotes	Cdkn1b
T31545	60245-60248	PR:000003090	denotes	p27
T31546	60259-60265	PR:000013042	denotes	Pou4f2
T31547	60267-60272	PR:000013042	denotes	Brn3b
T31548	60288-60293	PR:000016269	denotes	Tfdp1
T31549	60295-60298	PR:000016269	denotes	Dp1
T31550	60437-60444	PR:000014968	denotes	Slc18a3
T31551	60446-60451	PR:000014968	denotes	VAChT
T32240	60545-60557	GO:1990603	denotes	dark-adapted
T32241	60558-60562	NCBITaxon:10088	denotes	mice
T32242	60591-60595	NCBITaxon:10088	denotes	mice
T32243	60601-60613	GO:1990603	denotes	dark-adapted
T32244	60671-60679	CHEBI:6121	denotes	ketamine
T32245	60748-60754	UBERON:0001771	denotes	pupils
T32246	60820-60832	GO:1990603	denotes	dark-adapted
T32247	60834-60842	GO:1990603	denotes	scotopic
T32248	60848-60861	GO:0036367	denotes	light-adapted
T32249	60863-60871	GO:0036367	denotes	photopic
T32250	60885-60901	GO:0036367	denotes	Light adaptation
T33323	5272-5279	UBERON:0000966	denotes	retinal
T33324	5342-5348	GO:0005634	denotes	nuclei
T33325	5350-5354	CHEBI:51231	denotes	DAPI
T33326	5371-5378	GO:0051320	denotes	S-phase
T33327	5385-5389	CHEBI:472552	denotes	BrdU
T33328	5403-5412	GO:0006915	denotes	apoptosis
T33269	4237-4241	PR:000006852	denotes	E2f1
T33270	4251-4255	PR:000006853	denotes	E2f2
T33271	4259-4263	PR:000006854	denotes	E2f3
T33272	4299-4309	GO:0008219	denotes	Cell Death
T33273	4317-4319	PR:000013773	denotes	Rb
T33274	4323-4329	UBERON:0000966	denotes	Retina
T33275	4334-4341	UBERON:0000966	denotes	Retinal
T33276	4334-4353	GO:0060041	denotes	Retinal development
T33277	4366-4372	UBERON:0000966	denotes	retina
T33278	4394-4398	CL:0002672	denotes	RPCs
T33279	4420-4426	GO:0005634	denotes	nuclei
T33280	4429-4432	CL:0002672	denotes	RPC
T33281	4433-4444	GO:0044297	denotes	cell bodies
T33282	4461-4470	GO:0042995	denotes	processes
T33283	4500-4510	GO:0007049	denotes	cell cycle
T33284	4540-4544	CL:0002672	denotes	RPCs
T33285	4554-4561	GO:0007067	denotes	mitotic
T33286	4590-4596	GO:0005634	denotes	nuclei
T33287	4624-4627	UBERON:0001792	denotes	GCL
T33288	4659-4663	CL:0002672	denotes	RPCs
T33289	4709-4713	CL:0000604	denotes	rods
T33290	4715-4716	CL:0000604	denotes	r
T33291	4722-4727	CL:0000573	denotes	cones
T33292	4729-4730	CL:0000573	denotes	c
T33293	4739-4742	UBERON:0001789	denotes	ONL
T33294	4744-4754	_FRAGMENT	denotes	horizontal
T33295	4802-4807	CL:0000745	denotes	cells
T33296	4756-4757	CL:0000745	denotes	h
T33297	4760-4767	_FRAGMENT	denotes	bipolar
T33298	4802-4807	CL:0000103	denotes	cells
T33299	4769-4770	CL:0000103	denotes	b
T33300	4773-4779	_FRAGMENT	denotes	Müller
T33301	4802-4807	CL:0011107	denotes	cells
T33302	4781-4782	CL:0011107	denotes	m
T33303	4789-4797	_FRAGMENT	denotes	amacrine
T33304	4802-4807	CL:0000561	denotes	cells
T33305	4799-4800	CL:0000561	denotes	a
T33306	4815-4818	UBERON:0001791	denotes	INL
T33307	4824-4832	UBERON:0000045	denotes	ganglion
T33308	4824-4832	_FRAGMENT	denotes	ganglion
T33309	4860-4865	CL:0000740	denotes	cells
T33310	4834-4835	UBERON:0000045	denotes	g
T33311	4834-4835	_FRAGMENT	denotes	g
T33312	4851-4865	CL:0000561	denotes	amacrine cells
T33313	4873-4876	UBERON:0001792	denotes	GCL
T33314	4915-4917	PR:000013773	denotes	Rb
T33315	4932-4940	GO:0065007	denotes	regulate
T33316	4941-4951	GO:0007049	denotes	cell cycle
T33317	4956-4965	GO:0006915	denotes	apoptosis
T33318	5033-5039	UBERON:0000479	denotes	tissue
T33319	5081-5083	PR:000013773	denotes	Rb
T33320	5177-5182	GO:0016265	denotes	death
T33321	5206-5216	GO:0065007	denotes	regulation
T33322	5236-5241	SO:0000704	denotes	genes
T33329	5481-5485	CHEBI:472552	denotes	BrdU
T33330	5506-5510	CHEBI:472552	denotes	BrdU
T33331	5521-5524	UBERON:0001792	denotes	GCL
T33332	5613-5618	SO:0000704	denotes	genes
T33333	5625-5632	UBERON:0000966	denotes	retinas
T33334	5712-5719	NCBITaxon:33208	denotes	animals
T34326	14628-14632	PR:000006852	denotes	E2f1
T34327	14650-14658	UBERON:0000045	denotes	Ganglion
T34328	14650-14658	_FRAGMENT	denotes	Ganglion
T34329	14677-14682	CL:0000740	denotes	Cells
T34330	14660-14663	_FRAGMENT	denotes	Rod
T34331	14677-14682	CL:0000604	denotes	Cells
T34332	14669-14682	CL:0000748	denotes	Bipolar Cells
T34333	14690-14692	PR:000013773	denotes	Rb
T34334	14696-14702	UBERON:0000966	denotes	Retina
T34335	14718-14725	UBERON:0000966	denotes	retinal
T34336	14740-14744	NCBITaxon:10088	denotes	mice
T34337	14798-14804	GO:0005634	denotes	nuclei
T34338	14806-14810	CHEBI:51231	denotes	DAPI
T34339	14842-14850	UBERON:0000045	denotes	ganglion
T34340	14842-14856	CL:0000740	denotes	ganglion cells
T34341	14858-14864	PR:000013042	denotes	Pou4f2
T34342	14872-14876	CL:0000604	denotes	rods
T34343	14881-14886	CL:0000573	denotes	cones
T34344	14888-14891	PR:000014434	denotes	Sag
T34345	14893-14896	CL:0000604	denotes	rod
T34346	14893-14905	PR:000014434	denotes	rod arrestin
T34347	14920-14937	CL:0000751	denotes	rod bipolar cells
T34348	14939-14944	PR:000003058	denotes	Prkca
T34349	14957-14962	PR:000004937	denotes	Cabp5
T34350	15014-15020	PR:000013042	denotes	Pou4f2
T34351	15022-15030	UBERON:0000045	denotes	ganglion
T34352	15022-15036	CL:0000740	denotes	ganglion cells
T34353	15060-15065	PR:000003058	denotes	Prkca
T34354	15071-15076	PR:000004937	denotes	Cabp5
T34355	15078-15091	CL:0000103	denotes	bipolar cells
T34356	15114-15117	UBERON:0001789	denotes	ONL
T34357	15150-15154	CL:0000604	denotes	rods
T34358	15207-15214	NCBITaxon:33208	denotes	animals
T34359	15272-15279	UBERON:0000966	denotes	retinas
T34360	15481-15493	GO:1990603	denotes	dark-adapted
T34361	15495-15503	GO:1990603	denotes	scotopic
T34362	15715-15729	CL:0000210	denotes	photoreceptors
T34363	15880-15888	CL:0000103	denotes	bipolars
T35061	23721-23723	PR:000013773	denotes	Rb
T35062	23767-23769	PR:000013773	denotes	Rb
T35063	23778-23780	PR:000013773	denotes	Rb
T35064	23781-23785	PR:000006852	denotes	E2f1
T35065	23790-23796	UBERON:0000966	denotes	retina
T35066	23814-23820	GO:0005634	denotes	nuclei
T35067	23822-23826	CHEBI:51231	denotes	DAPI
T35068	23835-23840	PR:000004968	denotes	Calb2
T35069	23854-23861	PR:000014968	denotes	Slc18a3
T35070	23926-23928	PR:000013773	denotes	Rb
T35071	23932-23938	UBERON:0000966	denotes	retina
T35072	23956-23962	GO:0005634	denotes	nuclei
T35073	23964-23968	CHEBI:51231	denotes	DAPI
T35074	23986-23993	PR:000014968	denotes	Slc18a3
T35075	24010-24016	PR:000003199	denotes	Camk2a
T35076	24033-24035	PR:000013773	denotes	Rb
T35077	24079-24086	PR:000014968	denotes	Slc18a3
T35078	24137-24142	PR:000004968	denotes	Calb2
T35079	24144-24155	GO:0044297	denotes	cell bodies
T35080	24163-24166	UBERON:0001791	denotes	INL
T35081	24174-24181	PR:000014968	denotes	Slc18a3
T35082	24183-24194	GO:0044297	denotes	cell bodies
T35083	24200-24206	PR:000003199	denotes	Camk2a
T35084	24208-24219	GO:0044297	denotes	cell bodies
T35085	24227-24230	UBERON:0001791	denotes	INL
T35086	24283-24290	NCBITaxon:33208	denotes	animals
T35087	24347-24354	UBERON:0000966	denotes	retinas
T35930	28207-28213	GO:0005634	denotes	nuclei
T35931	28215-28219	CHEBI:51231	denotes	DAPI
T35932	28228-28235	GO:0007067	denotes	mitosis
T35933	28260-28267	PR:000014968	denotes	Slc18a3
T35934	28291-28295	GO:0044297	denotes	soma
T35927	28074-28078	PR:000006854	denotes	E2f3
T35928	28111-28113	PR:000013773	denotes	Rb
T35929	28137-28144	UBERON:0000966	denotes	retinal
T35935	28316-28325	GO:0042995	denotes	processes
T35936	28356-28363	GO:0007067	denotes	mitotic
T35937	28369-28375	GO:0005634	denotes	nuclei
T35938	28379-28381	PR:000013773	denotes	Rb
T35939	28386-28388	PR:000013773	denotes	Rb
T35940	28389-28393	PR:000006853	denotes	E2f2
T35941	28403-28405	PR:000013773	denotes	Rb
T35942	28406-28410	PR:000006854	denotes	E2f3
T35943	28415-28422	UBERON:0000966	denotes	retinas
T35944	28424-28428	PR:000006852	denotes	E2f1
T35945	28454-28461	GO:0007067	denotes	mitosis
T35946	28466-28476	GO:0008219	denotes	cell death
T35947	28510-28514	PR:000006853	denotes	E2f2
T35948	28535-28539	PR:000006854	denotes	E2f3
T35949	28573-28580	GO:0007067	denotes	mitosis
T35950	28645-28649	PR:000006852	denotes	E2f1
T35951	28654-28658	PR:000006854	denotes	E2f3
T35952	28688-28695	GO:0007067	denotes	mitosis
T35953	28697-28707	GO:0008219	denotes	cell death
T35954	28746-28752	PR:000003199	denotes	Camk2a
T35955	28780-28787	PR:000014968	denotes	Slc18a3
T35956	28800-28806	UBERON:0000966	denotes	retina
T35957	28826-28833	UBERON:0000966	denotes	retinal
T35958	28860-28866	GO:0005634	denotes	nuclei
T35959	28868-28872	CHEBI:51231	denotes	DAPI
T35960	28881-28888	PR:000014968	denotes	Slc18a3
T35961	28902-28906	PR:000009116	denotes	Isl1
T35962	28942-28946	PR:000009116	denotes	Isl1
T35963	28948-28955	PR:000014968	denotes	Slc18a3
T35964	28976-28979	UBERON:0001791	denotes	INL
T35965	28999-29006	UBERON:0000966	denotes	retinal
T35966	29060-29066	GO:0005634	denotes	nuclei
T35967	29068-29072	CHEBI:51231	denotes	DAPI
T35968	29081-29094	GO:0051301	denotes	cell division
T35969	29102-29107	PR:000010425	denotes	Mki67
T35970	29121-29125	PR:000009116	denotes	Isl1
T35971	29196-29200	PR:000009116	denotes	Isl1
T35972	29238-29245	UBERON:0000966	denotes	retinas
T35973	29265-29270	PR:000010425	denotes	Mki67
T35974	29325-29332	NCBITaxon:33208	denotes	animals
T35975	29389-29396	UBERON:0000966	denotes	retinas
T36708	34979-34983	PR:000006854	denotes	E2f3
T36709	34988-34990	PR:000013773	denotes	Rb
T36710	34991-35001	GO:0010467	denotes	Expression
T36711	35054-35061	UBERON:0000966	denotes	retinal
T36712	35115-35119	PR:000006854	denotes	E2f3
T36713	35130-35134	CHEBI:51231	denotes	DAPI
T36714	35188-35192	PR:000006854	denotes	E2f3
T36715	35198-35208	_FRAGMENT	denotes	peripheral
T36716	35227-35233	UBERON:0013682	denotes	retina
T36717	35255-35259	PR:000006854	denotes	E2f3
T36718	35286-35290	PR:000006854	denotes	E2f3
T36719	35294-35298	CL:0002672	denotes	RPCs
T36720	35312-35322	_FRAGMENT	denotes	peripheral
T36721	35329-35336	UBERON:0013682	denotes	retinal
T36722	35337-35344	CL:0000540	denotes	neurons
T36723	35374-35381	UBERON:0000966	denotes	retinal
T36724	35435-35437	PR:000013773	denotes	Rb
T36725	35448-35452	CHEBI:51231	denotes	DAPI
T36726	35481-35483	PR:000013773	denotes	Rb
T36727	35499-35509	_FRAGMENT	denotes	peripheral
T36728	35522-35529	UBERON:0013682	denotes	retinal
T36729	35510-35512	PR:000013773	denotes	Rb
T36730	35530-35537	CL:0000540	denotes	neurons
T36731	35550-35557	UBERON:0000966	denotes	retinal
T36732	35584-35590	GO:0005634	denotes	nuclei
T36733	35592-35596	CHEBI:51231	denotes	DAPI
T36734	35605-35609	PR:000006854	denotes	E2f3
T36735	35619-35621	PR:000013773	denotes	Rb
T36736	35643-35650	PR:000014968	denotes	Slc18a3
T36737	35692-35696	GO:0044297	denotes	soma
T36738	35716-35725	GO:0042995	denotes	processes
T37103	38906-38910	PR:000006854	denotes	E2f3
T37104	38911-38919	SO:0001060	denotes	Isoforms
T37105	38930-38940	GO:0007049	denotes	Cell Cycle
T37106	38968-38974	UBERON:0000966	denotes	Retina
T37107	38975-38982	GO:0005634	denotes	Nuclear
T37108	38987-38998	GO:0005737	denotes	cytoplasmic
T37109	39037-39044	UBERON:0000966	denotes	retinal
T37110	39037-39050	CL:0009004	denotes	retinal cells
T37111	39056-39060	NCBITaxon:10088	denotes	mice
T37112	39177-39182	PR:000028775	denotes	E2f3a
T37113	39186-39190	NCBITaxon:10088	denotes	mice
T37114	39240-39245	PR:000028775	denotes	E2f3a
T37115	39255-39256	GO:0005737	denotes	C
T37116	39258-39269	GO:0005737	denotes	cytoplasmic
T37117	39280-39281	GO:0005634	denotes	N
T37118	39283-39290	GO:0005634	denotes	nuclear
T37792	39315-39320	PR:000028775	denotes	E2f3a
T37793	39321-39328	SO:0001060	denotes	Isoform
T37794	39366-39368	PR:000013773	denotes	Rb
T37795	39407-39412	NCBITaxon:10088	denotes	mouse
T37796	39417-39422	PR:000028775	denotes	E2f3a
T37797	39450-39456	SO:0000359	denotes	floxed
T37798	39457-39461	PR:000006854	denotes	E2f3
T37799	39486-39490	PR:000006854	denotes	E2f3
T37800	39511-39516	PR:000028775	denotes	E2f3a
T37801	39520-39524	NCBITaxon:10088	denotes	mice
T37802	39538-39542	PR:000006854	denotes	E2f3
T37803	39543-39547	SO:0000147	denotes	exon
T37804	39563-39569	SO:0000188	denotes	intron
T37805	39611-39618	SO:0000112	denotes	primers
T37806	39637-39642	PR:000028775	denotes	E2f3a
T37807	39646-39651	NCBITaxon:10088	denotes	mouse
T37808	39699-39704	PR:000028775	denotes	E2f3a
T37809	39727-39733	UBERON:0000966	denotes	retina
T37810	39752-39759	SO:0000112	denotes	primers
T37811	39872-39878	UBERON:0000966	denotes	retina
T37812	39879-39888	GO:0010467	denotes	expresses
T37813	39894-39899	PR:000028775	denotes	E2f3a
T37814	39929-39934	PR:000028775	denotes	E2f3a
T37815	39938-39944	UBERON:0000966	denotes	retina
T37816	39951-39956	PR:000028775	denotes	E2f3a
T37817	39972-39981	GO:0010467	denotes	expresses
T37818	39994-39998	PR:000006854	denotes	E2f3
T37819	40002-40008	UBERON:0000966	denotes	retina
T37820	40027-40032	PR:000028775	denotes	E2f3a
T37821	40062-40071	GO:0010467	denotes	expresses
T37822	40097-40101	SO:0000147	denotes	exon
T37823	40142-40147	SO:0000704	denotes	genes
T37824	40154-40161	UBERON:0000966	denotes	retinas
T37825	40241-40248	NCBITaxon:33208	denotes	animals
T37826	40404-40406	PR:000013773	denotes	Rb
T37827	40418-40423	PR:000028775	denotes	E2f3a
T37828	40445-40452	UBERON:0000966	denotes	retinal
T37829	40515-40521	GO:0005634	denotes	nuclei
T37830	40523-40527	CHEBI:51231	denotes	DAPI
T37831	40536-40543	GO:0000279	denotes	M-phase
T37832	40577-40584	PR:000014968	denotes	Slc18a3
T37833	40592-40597	PR:000028775	denotes	E2f3a
T38511	47090-47092	PR:000013773	denotes	Rb
T38507	47006-47008	PR:000013773	denotes	Rb
T38508	47009-47018	GO:0065007	denotes	Regulates
T38509	47046-47050	PR:000006852	denotes	E2f1
T38510	47055-47060	PR:000028775	denotes	E2f3a
T38512	47190-47192	PR:000013773	denotes	Rb
T38513	47206-47208	PR:000013773	denotes	Rb
T38514	47235-47238	CL:0002672	denotes	RPC
T38515	47292-47296	CL:0002672	denotes	RPCs
T38516	47357-47364	GO:0007067	denotes	mitosis
T38517	47398-47400	PR:000013773	denotes	Rb
T38518	47438-47442	PR:000006852	denotes	E2f1
T38519	47444-47446	PR:000013773	denotes	Rb
T38520	47526-47531	PR:000028775	denotes	E2f3a
T38521	47566-47568	PR:000013773	denotes	Rb
T20089	41049-41051	PR:000013773	denotes	Rb
T20090	41068-41077	GO:0042995	denotes	processes
T20086	40949-40956	GO:0005634	denotes	nuclear
T27166	52220-52225	PR:000028775	denotes	E2f3a
T27167	52255-52260	PR:000028775	denotes	E2f3a
T27168	52405-52416	GO:0005737	denotes	cytoplasmic
T27169	52418-52423	PR:000028775	denotes	E2f3a
T27170	52456-52460	SO:0000704	denotes	gene
T27171	52461-52471	GO:0065007	denotes	regulation
T27172	52512-52520	GO:0065007	denotes	regulate
T27173	52537-52542	SO:0000704	denotes	genes
T27174	52556-52566	GO:0007049	denotes	cell cycle
T27175	52587-52593	PR:000003090	denotes	Cdkn1b
T27176	52600-52611	GO:0005737	denotes	cytoplasmic
T27177	52706-52713	GO:0005634	denotes	nucleus
T27178	52718-52727	GO:0005737	denotes	cytoplasm
T27746	53084-53092	CL:0000540	denotes	neuronal
T20087	40982-40993	GO:0005737	denotes	cytoplasmic
T24429	45977-45979	PR:000013773	denotes	Rb
T24430	45980-45988	GO:0065007	denotes	Controls
T24431	46017-46022	PR:000028775	denotes	E2f3a
T24432	46098-46105	UBERON:0000966	denotes	retinal
T24433	46106-46113	CL:0000540	denotes	neurons
T24434	46115-46119	PR:000006852	denotes	E2f1
T24435	46157-46159	PR:000013773	denotes	Rb
T24436	46163-46174	CHEBI:15355	denotes	cholinergic
T24437	46202-46206	PR:000006852	denotes	E2f1
T24438	46359-46371	CL:0000099	denotes	interneurons
T24439	46455-46457	PR:000013773	denotes	Rb
T24440	46458-46467	GO:0065007	denotes	regulates
T24441	46468-46480	GO:0022008	denotes	neurogenesis
T24442	46497-46504	GO:0007067	denotes	mitosis
T24443	46506-46508	PR:000013773	denotes	Rb
T18155	33128-33138	GO:0010467	denotes	Expression
T18156	33142-33146	PR:000006854	denotes	E2f3
T18157	33176-33179	UBERON:0001017	denotes	CNS
T18158	33176-33187	CL:0000117	denotes	CNS Neurons
T18159	33209-33213	PR:000006854	denotes	E2f3
T18160	33270-33277	UBERON:0000966	denotes	retinal
T18161	33278-33285	CL:0000540	denotes	neurons
T18162	33321-33331	GO:0010467	denotes	expression
T18163	33366-33370	PR:000006854	denotes	E2f3
T18164	33454-33459	NCBITaxon:10088	denotes	mouse
T18165	33460-33467	UBERON:0000479	denotes	tissues
T18166	33516-33520	PR:000006852	denotes	E2f1
T18167	33524-33528	PR:000006853	denotes	E2f2
T18168	33586-33590	PR:000006854	denotes	E2f3
T18216	35793-35797	PR:000006854	denotes	E2f3
T18217	35840-35847	CL:0000540	denotes	neurons
T18218	35859-35872	UBERON:0002616	denotes	brain regions
T18219	35915-35923	UBERON:0001876	denotes	amygdala
T18220	35925-35929	PR:000006854	denotes	E2f3
T18221	35959-35967	CL:0000540	denotes	neuronal
T18222	35976-35981	PR:000010124	denotes	Mtap2
T18223	35986-35991	PR:000010277	denotes	Mecp2
T18224	36011-36016	PR:000004968	denotes	Calb2
T18225	36042-36049	CL:0000540	denotes	neurons
T18226	36063-36068	CL:0000125	denotes	glial
T18227	36076-36080	PR:000007939	denotes	Gfap
T18228	36109-36116	UBERON:0000966	denotes	retinal
T18229	36123-36127	PR:000006854	denotes	E2f3
T18230	36138-36147	GO:0010467	denotes	expressed
T18231	36160-36167	PR:000014968	denotes	Slc18a3
T20088	40994-40996	PR:000013773	denotes	Rb
T20057	37938-37949	GO:0005737	denotes	cytoplasmic
T20058	38007-38014	GO:0005634	denotes	nuclear
T20059	38063-38068	PR:000028775	denotes	E2f3a
T20060	38173-38180	GO:0005634	denotes	nuclear
T20061	38220-38229	GO:0005737	denotes	cytoplasm
T20062	38266-38271	PR:000028775	denotes	E2f3a
T20063	38322-38327	PR:000028775	denotes	E2f3a
T20064	38331-38337	UBERON:0000966	denotes	retina
T20065	38363-38369	PR:000013042	denotes	Pou4f2
T20066	38373-38380	GO:0005634	denotes	nuclear
T20067	38402-38411	GO:0010467	denotes	expressed
T20068	38415-38423	UBERON:0000045	denotes	ganglion
T20069	38415-38429	CL:0000740	denotes	ganglion cells
T20070	38443-38450	GO:0005634	denotes	nuclear
T20071	38485-38496	GO:0005737	denotes	cytoplasmic
T20072	38523-38530	PR:000014968	denotes	Slc18a3
T20073	38534-38545	GO:0005737	denotes	cytoplasmic
T20074	38678-38683	PR:000028775	denotes	E2f3a
T20075	38780-38785	PR:000028775	denotes	E2f3a
T20076	38806-38815	GO:0065007	denotes	regulated
T20077	38839-38852	GO:0006412	denotes	translational
T20078	40762-40772	GO:0007049	denotes	cell cycle
T20079	40791-40798	UBERON:0000966	denotes	retinal
T20080	40791-40810	GO:0060041	denotes	retinal development
T20081	40817-40822	PR:000028775	denotes	E2f3a
T20082	40824-40826	PR:000013773	denotes	Rb
T20083	40854-40863	GO:0005737	denotes	cytoplasm
T20084	40868-40875	GO:0005634	denotes	nucleus
T20085	40914-40916	PR:000013773	denotes	Rb
T6654	13596-13602	SO:0001023	denotes	allele
T6634	12817-12825	UBERON:0000045	denotes	ganglion
T6635	12830-12838	CL:0000561	denotes	amacrine
T6636	12894-12900	UBERON:0000966	denotes	retina
T6637	12908-12912	CHEBI:472552	denotes	BrdU
T6638	12914-12927	CL:0000210	denotes	photoreceptor
T6639	12998-13000	PR:000013773	denotes	Rb
T6640	13004-13011	UBERON:0000966	denotes	retinas
T6641	13092-13098	UBERON:0000966	denotes	retina
T6642	13160-13167	GO:0051320	denotes	S-phase
T6643	13272-13274	PR:000013773	denotes	Rb
T6644	13275-13279	PR:000006852	denotes	E2f1
T6645	13284-13290	UBERON:0000966	denotes	retina
T6646	13351-13355	PR:000006853	denotes	E2f2
T6647	13359-13363	PR:000006854	denotes	E2f3
T6648	13419-13426	GO:0007067	denotes	mitotic
T6649	13475-13485	GO:0042571	denotes	antibodies
T6650	13509-13513	PR:000006852	denotes	E2f1
T6651	13523-13527	PR:000006853	denotes	E2f2
T6652	13531-13535	PR:000006854	denotes	E2f3
T6653	13591-13595	PR:000006852	denotes	E2f1
T6655	13632-13639	GO:0051320	denotes	S-phase
T6656	13644-13651	GO:0007067	denotes	mitosis
T6657	13655-13657	PR:000013773	denotes	Rb
T6658	13721-13725	PR:000006852	denotes	E2f1
T6659	13753-13755	PR:000013773	denotes	Rb
T6660	13852-13855	UBERON:0001017	denotes	CNS
T6661	13859-13861	PR:000013773	denotes	Rb
T6662	13865-13872	UBERON:0000922	denotes	embryos
T6663	13969-13971	PR:000013773	denotes	Rb
T6664	13979-13985	UBERON:0000966	denotes	retina
T6665	14014-14023	GO:0006915	denotes	apoptosis
T6666	14042-14049	_FRAGMENT	denotes	bipolar
T6667	14063-14068	CL:0000103	denotes	cells
T6668	14054-14062	UBERON:0000045	denotes	ganglion
T6669	14054-14068	CL:0000740	denotes	ganglion cells
T6688	16012-16016	PR:000006852	denotes	E2f1
T6689	16034-16044	GO:0010467	denotes	expression
T6690	16083-16088	SO:0000704	denotes	genes
T6691	16094-16102	GO:0065007	denotes	regulate
T6692	16107-16117	GO:0007049	denotes	cell cycle
T6693	16122-16131	GO:0006915	denotes	apoptosis
T6694	16164-16174	GO:0007049	denotes	cell cycle
T6695	16225-16227	PR:000013773	denotes	Rb
T6696	16231-16237	UBERON:0000966	denotes	retina
T6697	16273-16277	PR:000006852	denotes	E2f1
T6698	16279-16283	PR:000006853	denotes	E2f2
T6699	16285-16290	PR:000028775	denotes	E2f3a
T6700	16296-16300	PR:000006858	denotes	E2f7
T6701	16324-16326	PR:000013773	denotes	Rb
T6702	16344-16348	PR:000006855	denotes	E2f4
T6703	16354-16358	PR:000006856	denotes	E2f5
T6704	16396-16400	CHEBI:472552	denotes	BrdU
T6705	16456-16460	PR:000006852	denotes	E2f1
T6706	16525-16529	PR:000006854	denotes	E2f3
T13408	22706-22716	GO:0007049	denotes	Cell Cycle
T13409	22760-22773	CL:0000210	denotes	photoreceptor
T13410	22778-22790	CL:0000103	denotes	bipolar cell
T13411	22900-22902	PR:000013773	denotes	Rb
T13412	22903-22907	PR:000006852	denotes	E2f1
T3341	3195-3201	UBERON:0000966	denotes	retina
T3342	3220-3226	UBERON:0000479	denotes	tissue
T3343	3236-3248	GO:0022008	denotes	neurogenesis
T3344	3321-3328	UBERON:0000966	denotes	retinal
T3345	3321-3344	CL:0002672	denotes	retinal progenitor cell
T3346	3340-3344	_FRAGMENT	denotes	cell
T3347	3351-3364	GO:0008283	denotes	proliferation
T3348	3346-3349	CL:0002672	denotes	RPC
T3349	3392-3399	GO:0007067	denotes	mitotic
T3350	3400-3407	UBERON:0000966	denotes	retinal
T3351	3549-3553	CL:0002672	denotes	RPCs
T3352	3583-3593	GO:0007049	denotes	cell cycle
T3353	3735-3745	GO:0007049	denotes	cell cycle
T3354	3768-3775	GO:0007067	denotes	mitotic
T3355	3808-3822	UBERON:0001781	denotes	retinal layers
T3356	3824-3828	CL:0000604	denotes	Rods
T3357	3833-3838	CL:0000573	denotes	cones
T3358	3851-3870	UBERON:0001789	denotes	outer nuclear layer
T3359	3857-3864	GO:0005634	denotes	nuclear
T3360	3872-3875	UBERON:0001789	denotes	ONL
T3361	3878-3888	_FRAGMENT	denotes	horizontal
T3362	3912-3917	CL:0000745	denotes	cells
T3363	3890-3897	_FRAGMENT	denotes	bipolar
T3364	3912-3917	CL:0000103	denotes	cells
T3365	3903-3917	CL:0000561	denotes	amacrine cells
T3366	3930-3946	CL:0011107	denotes	Müller glia cell
T3367	3942-3953	GO:0044297	denotes	cell bodies
T3368	3969-3988	UBERON:0001791	denotes	inner nuclear layer
T3369	3975-3982	GO:0005634	denotes	nuclear
T3370	3990-3993	UBERON:0001791	denotes	INL
T3371	4000-4008	UBERON:0000045	denotes	ganglion
T3372	4000-4008	_FRAGMENT	denotes	ganglion
T3373	4032-4037	CL:0000740	denotes	cells
T3395	5911-5914	CL:0000561	denotes	ma
T3396	5915-5916	GO:0065007	denotes	r
T3397	5916-5918	GO:0006915	denotes	ot
T3398	5927-5930	PR:000013773	denotes	is
T3399	5943-5953	GO:0007049	denotes	cell cycle
T3400	5966-5973	UBERON:0000966	denotes	retinal
T3401	5997-5999	PR:000013773	denotes	Rb
T3402	6031-6042	GO:0008283	denotes	proliferate
T3403	6069-6072	_FRAGMENT	denotes	rod
T3404	6096-6101	CL:0000604	denotes	cells
T3405	6074-6082	UBERON:0000045	denotes	ganglion
T3406	6074-6082	_FRAGMENT	denotes	ganglion
T3407	6096-6101	CL:0000740	denotes	cells
T3408	6088-6101	CL:0000103	denotes	bipolar cells
T3409	6103-6106	GO:0016265	denotes	die
T3410	6110-6119	GO:0006915	denotes	apoptosis
T3411	6127-6129	PR:000013773	denotes	Rb
T3412	6130-6138	GO:0065007	denotes	controls
T3413	6143-6153	GO:0007049	denotes	cell cycle
T3414	6275-6285	NCBITaxon:10508	denotes	adenoviral
T3415	6289-6299	GO:0065007	denotes	regulatory
T3416	6289-6308	SO:0005836	denotes	regulatory elements
R281	T3499	T3498	_lexicallyChainedTo	cells,differentiation of
R1513	T6667	T6666	_lexicallyChainedTo	cells,bipolar
R1514	T6675	T6674	_lexicallyChainedTo	cells,death of
R1515	T6677	T6676	_lexicallyChainedTo	neurons,bipolar
R2298	T8904	T8903	_lexicallyChainedTo	cells,retinal bipolar
R2299	T8906	T8905	_lexicallyChainedTo	ganglion,retinal
R2300	T8907	T8906	_lexicallyChainedTo	cells,ganglion
R2301	T8908	T8905	_lexicallyChainedTo	rod cells,retinal
R3519	T13423	T13422	_lexicallyChainedTo	cell,amacrine
R3520	T13459	T13458	_lexicallyChainedTo	retina,peripheral
R3521	T13484	T13483	_lexicallyChainedTo	neurons,horizontal
R4449	T16134	T16133	_lexicallyChainedTo	death,cell
R4450	T16161	T16160	_lexicallyChainedTo	cell,bipolar
R6611	T22861	T22859	_lexicallyChainedTo	cells,development of
R7833	T26534	T26533	_lexicallyChainedTo	epithelia,gut
R7834	T26556	T26555	_lexicallyChainedTo	cells,division of
R9132	T30715	T30714	_lexicallyChainedTo	primer,forward
R9929	T33295	T33294	_lexicallyChainedTo	cells,horizontal
R9930	T33298	T33297	_lexicallyChainedTo	cells,bipolar
R9931	T33301	T33300	_lexicallyChainedTo	cells,Müller
R9932	T33304	T33303	_lexicallyChainedTo	cells,amacrine
R9933	T33309	T33308	_lexicallyChainedTo	cells,ganglion
R9934	T33309	T33311	_lexicallyChainedTo	cells,g
R10312	T34329	T34328	_lexicallyChainedTo	Cells,Ganglion
R10313	T34331	T34330	_lexicallyChainedTo	Cells,Rod
R11100	T36716	T36715	_lexicallyChainedTo	retina,peripheral
R11101	T36721	T36720	_lexicallyChainedTo	retinal,peripheral
R11102	T36728	T36727	_lexicallyChainedTo	retinal,peripheral
R2297	T8881	T8880	_lexicallyChainedTo	segments,inner
R2929	T10829	T10828	_lexicallyChainedTo	bipolar cells,rod
R2930	T10833	T10832	_lexicallyChainedTo	cells,activation of
R2931	T10841	T10840	_lexicallyChainedTo	cell,rod
R2932	T10842	T10840	_lexicallyChainedTo	apoptosis,rod
R5189	T18235	T18234	_lexicallyChainedTo	brain,regions of
R5190	T18236	T18234	_lexicallyChainedTo	spinal cord,regions of
R5191	T18239	T18238	_lexicallyChainedTo	neurons,cholinergic
R1	T520	T519	_lexicallyChainedTo	neurons,death of
R2	T523	T522	_lexicallyChainedTo	cells,responses in
R3	T529	T528	_lexicallyChainedTo	1,E2f transcription factor
R4	T529	T530	_lexicallyChainedTo	1,E2f
R6608	T22775	T22774	_lexicallyChainedTo	Death,Cell
R6609	T22805	T22804	_lexicallyChainedTo	cells,bipolar
R6610	T22860	T22859	_lexicallyChainedTo	cells,development of
R272	T3404	T3403	_lexicallyChainedTo	cells,rod
R273	T3347	T3346	_lexicallyChainedTo	proliferation,cell
R274	T3407	T3406	_lexicallyChainedTo	cells,ganglion
R276	T3362	T3361	_lexicallyChainedTo	cells,horizontal
R277	T3364	T3363	_lexicallyChainedTo	cells,bipolar
R278	T3373	T3372	_lexicallyChainedTo	cells,ganglion
R279	T3390	T3389	_lexicallyChainedTo	s,bla

2_test

Id	Subject	Object	Predicate	Lexical cue
17608565-15685194-84868941	3545-3546	15685194	denotes	1
17608565-15685194-84868942	3662-3663	15685194	denotes	1
17608565-15193257-84868943	6121-6122	15193257	denotes	2
17608565-15231717-84868944	6123-6124	15231717	denotes	3
17608565-12473340-84868945	6370-6371	12473340	denotes	4
17608565-11719808-84868946	6372-6373	11719808	denotes	5
17608565-12473340-84868947	6659-6660	12473340	denotes	4
17608565-11719808-84868948	6661-6662	11719808	denotes	5
17608565-9774968-84868949	6791-6792	9774968	denotes	6
17608565-11146559-84868949	6791-6792	11146559	denotes	6
17608565-11230146-84868949	6791-6792	11230146	denotes	6
17608565-12065245-84868949	6791-6792	12065245	denotes	6
17608565-9207076-84868950	7222-7224	9207076	denotes	10
17608565-9774968-84868951	7397-7398	9774968	denotes	6
17608565-12944480-84868952	7399-7401	12944480	denotes	11
17608565-12607001-84868953	7510-7512	12607001	denotes	12
17608565-12093735-84868953	7510-7512	12093735	denotes	12
17608565-12529408-84868953	7510-7512	12529408	denotes	12
17608565-15976820-84868954	7605-7607	15976820	denotes	15
17608565-10779352-84868955	8047-8049	10779352	denotes	16
17608565-10779352-84868956	8187-8189	10779352	denotes	16
17608565-10779352-84868957	8372-8374	10779352	denotes	16
17608565-10918599-84868957	8372-8374	10918599	denotes	16
17608565-11980909-84868957	8372-8374	11980909	denotes	16
17608565-15175242-84868958	8461-8463	15175242	denotes	19
17608565-10779352-84868959	8574-8576	10779352	denotes	16
17608565-9144196-84868960	8750-8752	9144196	denotes	20
17608565-9271426-84868960	8750-8752	9271426	denotes	20
17608565-9372959-84868960	8750-8752	9372959	denotes	20
17608565-10725332-84868961	8791-8793	10725332	denotes	23
17608565-11161609-84868961	8791-8793	11161609	denotes	23
17608565-15869948-84868961	8791-8793	15869948	denotes	23
17608565-1406933-84868962	8938-8940	1406933	denotes	26
17608565-1406932-84868962	8938-8940	1406932	denotes	26
17608565-7958874-84868962	8938-8940	7958874	denotes	26
17608565-14991054-84868962	8938-8940	14991054	denotes	26
17608565-9420334-84868963	9459-9461	9420334	denotes	30
17608565-8381715-84868963	9459-9461	8381715	denotes	30
17608565-11545733-84868963	9459-9461	11545733	denotes	30
17608565-8946919-84868963	9459-9461	8946919	denotes	30
17608565-14991054-84868964	9631-9633	14991054	denotes	29
17608565-12192402-84868965	10493-10495	12192402	denotes	34
17608565-12459782-84868965	10493-10495	12459782	denotes	34
17608565-16462736-84868965	10493-10495	16462736	denotes	34
17608565-15175242-84868966	11217-11219	15175242	denotes	19
17608565-15193257-84868967	11778-11779	15193257	denotes	2
17608565-11719808-84868968	11910-11911	11719808	denotes	5
17608565-15193257-84868969	12398-12399	15193257	denotes	2
17608565-11719808-84868970	12400-12401	11719808	denotes	5
17608565-15193257-84868971	12615-12616	15193257	denotes	2
17608565-15231717-84868972	12617-12618	15231717	denotes	3
17608565-15193257-84868973	12970-12971	15193257	denotes	2
17608565-9774968-84868974	13955-13956	9774968	denotes	6
17608565-11146559-84868974	13955-13956	11146559	denotes	6
17608565-11230146-84868974	13955-13956	11230146	denotes	6
17608565-12065245-84868974	13955-13956	12065245	denotes	6
17608565-15193257-84868975	14106-14107	15193257	denotes	2
17608565-15231717-84868976	14108-14109	15231717	denotes	3
17608565-15193257-84868977	14328-14329	15193257	denotes	2
17608565-14991054-84868978	17928-17930	14991054	denotes	29
17608565-9420334-84868979	19905-19907	9420334	denotes	30
17608565-8381715-84868979	19905-19907	8381715	denotes	30
17608565-11545733-84868979	19905-19907	11545733	denotes	30
17608565-8946919-84868979	19905-19907	8946919	denotes	30
17608565-15193257-84868980	20774-20775	15193257	denotes	2
17608565-15193257-84868981	21518-21519	15193257	denotes	2
17608565-10888735-84868982	24623-24625	10888735	denotes	37
17608565-9786999-84868983	24687-24689	9786999	denotes	38
17608565-12192402-84868984	24741-24743	12192402	denotes	34
17608565-12459782-84868985	24744-24746	12459782	denotes	35
17608565-16462736-84868986	24829-24831	16462736	denotes	36
17608565-14766316-84868987	25063-25065	14766316	denotes	39
17608565-10888735-84868988	25168-25170	10888735	denotes	37
17608565-10888735-84868989	25404-25406	10888735	denotes	37
17608565-12687700-84868990	25613-25615	12687700	denotes	40
17608565-15317859-84868991	25741-25743	15317859	denotes	41
17608565-10888735-84868992	25913-25915	10888735	denotes	37
17608565-15223342-84868993	26270-26272	15223342	denotes	42
17608565-10888735-84868994	26698-26700	10888735	denotes	37
17608565-11447760-84868995	29607-29609	11447760	denotes	43
17608565-8381715-84868996	29795-29797	8381715	denotes	31
17608565-11545733-84868996	29795-29797	11545733	denotes	31
17608565-8946919-84868996	29795-29797	8946919	denotes	31
17608565-11159908-84868997	30123-30125	11159908	denotes	44
17608565-12110166-84868997	30123-30125	12110166	denotes	44
17608565-12975318-84868997	30123-30125	12975318	denotes	44
17608565-15479636-84868997	30123-30125	15479636	denotes	44
17608565-16081278-84868997	30123-30125	16081278	denotes	44
17608565-9315903-84868998	31732-31734	9315903	denotes	49
17608565-15193257-84868999	32265-32266	15193257	denotes	2
17608565-12871981-84869000	33560-33562	12871981	denotes	50
17608565-15939381-84869001	34670-34672	15939381	denotes	51
17608565-12605461-84869002	35993-35995	12605461	denotes	52
17608565-9786999-84869003	41149-41151	9786999	denotes	38
17608565-8923205-84869004	41382-41384	8923205	denotes	54
17608565-16909124-84869005	42591-42593	16909124	denotes	55
17608565-10779352-84869006	42806-42808	10779352	denotes	16
17608565-15175242-84869007	42809-42811	15175242	denotes	19
17608565-1406933-84869008	43285-43287	1406933	denotes	26
17608565-1406932-84869008	43285-43287	1406932	denotes	26
17608565-7958874-84869008	43285-43287	7958874	denotes	26
17608565-12607001-84869009	43387-43389	12607001	denotes	12
17608565-12093735-84869009	43387-43389	12093735	denotes	12
17608565-12529408-84869009	43387-43389	12529408	denotes	12
17608565-15193257-84869010	43591-43592	15193257	denotes	2
17608565-15231717-84869011	43593-43594	15231717	denotes	3
17608565-12093735-84869012	43595-43597	12093735	denotes	13
17608565-12529408-84869013	43598-43600	12529408	denotes	14
17608565-7925271-84869014	43601-43603	7925271	denotes	56
17608565-9620848-84869014	43601-43603	9620848	denotes	56
17608565-9508781-84869014	43601-43603	9508781	denotes	56
17608565-11435948-84869014	43601-43603	11435948	denotes	56
17608565-14991054-84869015	44556-44558	14991054	denotes	29
17608565-11704831-84869016	44996-44998	11704831	denotes	60
17608565-9207076-84869017	45167-45169	9207076	denotes	10
17608565-15976820-84869018	45170-45172	15976820	denotes	15
17608565-11447760-84869019	46538-46540	11447760	denotes	43
17608565-8381715-84869020	46718-46720	8381715	denotes	31
17608565-11545733-84869020	46718-46720	11545733	denotes	31
17608565-8946919-84869020	46718-46720	8946919	denotes	31
17608565-10601020-84869021	46821-46823	10601020	denotes	61
17608565-11684023-84869022	46857-46859	11684023	denotes	62
17608565-11034201-84869023	46860-46862	11034201	denotes	63
17608565-15175242-84869024	48713-48715	15175242	denotes	19
17608565-10779352-84869025	49466-49468	10779352	denotes	16
17608565-8033208-84869026	49861-49863	8033208	denotes	64
17608565-7969176-84869027	49864-49866	7969176	denotes	65
17608565-11980909-84869028	49948-49950	11980909	denotes	18
17608565-9144196-84869029	50097-50099	9144196	denotes	20
17608565-9271426-84869029	50097-50099	9271426	denotes	20
17608565-9372959-84869029	50097-50099	9372959	denotes	20
17608565-10725332-84869030	50473-50475	10725332	denotes	23
17608565-15193257-84869031	51394-51395	15193257	denotes	2
17608565-12093735-84869032	51546-51548	12093735	denotes	13
17608565-17257418-84869033	51693-51695	17257418	denotes	67
17608565-11159908-84869034	52544-52546	11159908	denotes	44
17608565-12110166-84869034	52544-52546	12110166	denotes	44
17608565-12975318-84869034	52544-52546	12975318	denotes	44
17608565-15479636-84869034	52544-52546	15479636	denotes	44
17608565-16081278-84869034	52544-52546	16081278	denotes	44
17608565-16705040-84869035	52655-52657	16705040	denotes	68
17608565-15078817-84869036	52658-52660	15078817	denotes	69
17608565-17043310-84869037	52756-52758	17043310	denotes	70
17608565-9786999-84869038	52982-52984	9786999	denotes	38
17608565-8381715-84869039	53130-53132	8381715	denotes	31
17608565-11545733-84869039	53130-53132	11545733	denotes	31
17608565-8946919-84869039	53130-53132	8946919	denotes	31
17608565-9420334-84869040	53370-53372	9420334	denotes	30
17608565-15193257-84869041	54687-54688	15193257	denotes	2
17608565-11719808-84869042	54689-54690	11719808	denotes	5
17608565-12871981-84869043	55594-55596	12871981	denotes	50
17608565-12093735-84869044	55660-55662	12093735	denotes	13
17608565-15193257-84869045	56909-56910	15193257	denotes	2
17608565-16195385-84869046	58325-58327	16195385	denotes	71
17608565-11528395-84869047	60577-60579	11528395	denotes	72
T35231	3545-3546	15685194	denotes	1
T34771	3662-3663	15685194	denotes	1
T68391	6121-6122	15193257	denotes	2
T52784	6123-6124	15231717	denotes	3
T97361	6370-6371	12473340	denotes	4
T36661	6372-6373	11719808	denotes	5
T48203	6659-6660	12473340	denotes	4
T21588	6661-6662	11719808	denotes	5
T16930	6791-6792	9774968	denotes	6
T99767	6791-6792	11146559	denotes	6
T79985	6791-6792	11230146	denotes	6
T2705	6791-6792	12065245	denotes	6
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PMC:1914394 JSONTXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

craft-ca-core-ex-dev

craft-ca-core-dev

2_test

PMC:1914394 JSON TXT