PMC:1892782 / 4256-5209 JSONTXT

{"project":"2_test","denotations":[{"id":"17540014-15665081-1690047","span":{"begin":834,"end":836},"obj":"15665081"}],"text":"2) Mean of the energy z-scores of the individual sequences contained in the alignment (meanz). The z-score is defined as z = (E - E¯ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacuWGfbqrgaqeaaaa@2DD7@)/σ, where E¯ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacuWGfbqrgaqeaaaa@2DD7@ and σ are mean and standard deviation of the folding energy distribution of shuffled (permuted) sequences. We use here the same SVM-regression procedure as RNAz [15] to estimate the z-scores from the sequence composition to avoid the time consuming sampling of shuffled alignments."}