PMC:1892782 / 3326-4041 JSONTXT

{"project":"2_test","denotations":[{"id":"17540014-15296519-1690045","span":{"begin":493,"end":495},"obj":"15296519"},{"id":"17540014-11574674-1690046","span":{"begin":541,"end":543},"obj":"11574674"}],"text":"The effects of both the asymmetries of the energy rules and of the GU base pairs are conveniently captured in terms of thermodynamic quantities, more precisely, in terms of the folding energies of the consensus structure and the individual folding energies of a set of aligned RNAs. These parameters can be computed much more reliably than quantities that have to be derived from predicted base pairs due to the limited accuracy of the structure prediction algorithms on individual sequences [12]. We avoid the use of sequence motifs (e.g. [13]), since this bears the danger that the SVM is biased to the ncRNA families in the training set and fails to distinguish plus and minus strands of other structured ncRNAs."}